Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ADAMTS20	80070	broad.mit.edu	37	12	43824155	43824155	+	Splice_Site	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr12:43824155C>T	ENST00000389420.3	-	23	3380	c.3381_splice	c.e23+1	p.Q1127_splice	ADAMTS20_ENST00000553158.1_Splice_Site_p.Q1127_splice|ADAMTS20_ENST00000395541.2_Splice_Site_p.Q281_splice	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1127	TSP type-1 6.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TTCTTTTTACCTGTCTGTCAC	0.348000													10	18					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46244079	46244079	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr12:46244079C>T	ENST00000334344.6	+	15	2345	c.2173C>T	c.(2173-2175)Cag>Tag	p.Q725*	ARID2_ENST00000444670.1_Nonsense_Mutation_p.Q335*|ARID2_ENST00000422737.1_Nonsense_Mutation_p.Q576*|ARID2_ENST00000479608.1_3'UTR	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	725					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TTCCATACCCCAGACAGGAGT	0.443000			"""N, S, F"""		hepatocellular carcinoma								39	61					0	0	1	0	0
FKRP	79147	broad.mit.edu	37	19	47258849	47258849	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr19:47258849C>T	ENST00000318584.5	+	4	439	c.142C>T	c.(142-144)Cgt>Tgt	p.R48C	FKRP_ENST00000600646.1_Intron|FKRP_ENST00000391909.3_Missense_Mutation_p.R48C	NM_001039885.2|NM_024301.4	NP_001034974.1|NP_077277.1	Q9H9S5	FKRP_HUMAN	fukutin related protein	48						extracellular space|Golgi apparatus|rough endoplasmic reticulum|sarcolemma	transferase activity			NS(1)|large_intestine(1)|lung(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	7		all_epithelial(76;5.08e-05)|Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000541)|all cancers(93;0.00128)|Epithelial(262;0.0207)|GBM - Glioblastoma multiforme(486;0.0336)		TGCCGGCCCCCGTGTCACCGT	0.662000													5	7					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179600503	179600503	+	Silent	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr2:179600503G>A	ENST00000589042.1	-	50	14894	c.14670C>T	c.(14668-14670)ttC>ttT	p.F4890F	TTN_ENST00000591111.1_Silent_p.F4573F|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000582847.1_RNA|TTN_ENST00000342992.6_Silent_p.F3646F|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4573	Ig-like 29.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTCTTTAATGAAATGTGGCT	0.413000													9	22					0	0	1	0	0
MYO5C	55930	broad.mit.edu	37	15	52538156	52538156	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr15:52538156G>A	ENST00000261839.7	-	17	2224	c.2063C>T	c.(2062-2064)tCc>tTc	p.S688F	MYO5C_ENST00000443683.2_3'UTR	NM_018728.3	NP_061198.2	Q9NQX4	MYO5C_HUMAN	myosin VC	688	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		AACATACCTGGAAGGGTAGCT	0.448000													24	52					0	0	1	0	0
LINGO4	339398	broad.mit.edu	37	1	151774425	151774425	+	Silent	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr1:151774425G>A	ENST00000368820.3	-	2	1693	c.756C>T	c.(754-756)ctC>ctT	p.L252L		NM_001004432.2	NP_001004432.1	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	252						integral to membrane				breast(2)|cervix(1)|endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TGCTGAGATTGAGCCCAACCA	0.637000													28	42					0	0	1	0	0
SLC8A1	6546	broad.mit.edu	37	2	40657293	40657293	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr2:40657293C>T	ENST00000406785.1	-	2	317	c.128G>A	c.(127-129)gGa>gAa	p.G43E	SLC8A1_ENST00000405901.3_Missense_Mutation_p.G43E|SLC8A1_ENST00000405269.1_Missense_Mutation_p.G43E|SLC8A1_ENST00000403092.1_Missense_Mutation_p.G43E|SLC8A1_ENST00000402441.1_Missense_Mutation_p.G43E|SLC8A1_ENST00000332839.4_Missense_Mutation_p.G43E|SLC8A1_ENST00000542756.1_Missense_Mutation_p.G43E|SLC8A1_ENST00000542024.1_Missense_Mutation_p.G43E|SLC8A1_ENST00000408028.2_Missense_Mutation_p.G43E|SLC8A1_ENST00000406391.2_Missense_Mutation_p.G43E			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	43					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	AGTTTCATTTCCTTCTCCTTC	0.413000													38	73					0	0	1	0	0
ACSM5	54988	broad.mit.edu	37	16	20435364	20435364	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr16:20435364C>T	ENST00000331849.4	+	6	1041	c.894C>T	c.(892-894)ccC>ccT	p.P298P		NM_017888.2	NP_060358.2	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	298					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(3)|urinary_tract(1)	51						ATGAGCTGCCCCGAGTTGATG	0.463000													18	67					0	0	1	0	0
CDR1	1038	broad.mit.edu	37	X	139866437	139866437	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chrX:139866437G>A	ENST00000370532.2	-	1	286	c.95C>T	c.(94-96)cCt>cTt	p.P32L		NM_004065.2	NP_004056.2	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1, 34kDa	32	23 X 6 AA approximate repeats.									breast(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(2)|skin(4)|urinary_tract(1)	25	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				TTCCAACAAAGGTACGTCTTC	0.443000													76	106					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185801324	185801324	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr2:185801324C>T	ENST00000302277.6	+	4	1795	c.1201C>T	c.(1201-1203)Cct>Tct	p.P401S		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	401						intracellular	zinc ion binding	p.P401T(1)		NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						GACATTGGCCCCTTCAAATAC	0.383000													28	47					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124887093	124887093	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr12:124887093C>T	ENST00000356219.3	-	15	1652	c.1497G>A	c.(1495-1497)caG>caA	p.Q499Q	NCOR2_ENST00000429285.2_Silent_p.Q498Q|NCOR2_ENST00000397355.1_Silent_p.Q499Q|NCOR2_ENST00000405201.1_Silent_p.Q499Q|NCOR2_ENST00000404621.1_Silent_p.Q498Q|NCOR2_ENST00000404121.2_Silent_p.Q69Q	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	499	Poly-Gln.				cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity	p.Q499Q(9)		breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		gctgctgctgctgttgttgct	0.617000													3	14					0	0	1	0	0
PURA	5813	broad.mit.edu	37	5	139494170	139494170	+	Missense_Mutation	SNP	C	C	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr5:139494170C>A	ENST00000331327.3	+	1	463	c.404C>A	c.(403-405)gCg>gAg	p.A135E		NM_005859.4	NP_005850.1	Q00577	PURA_HUMAN	purine-rich element binding protein A	135					DNA unwinding involved in replication|DNA-dependent DNA replication initiation	DNA replication factor A complex	double-stranded telomeric DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|single-stranded DNA binding|transcription factor binding			central_nervous_system(1)|lung(2)|ovary(1)|prostate(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGCCCAGGCGCAGGACGAG	0.667000													2	3					1	1	1	1	0
SCP2	6342	broad.mit.edu	37	1	53444004	53444004	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr1:53444004C>T	ENST00000371514.3	+	9	958	c.790C>T	c.(790-792)Cca>Tca	p.P264S	SCP2_ENST00000371513.5_Missense_Mutation_p.P220S|SCP2_ENST00000528311.1_Missense_Mutation_p.P183S|SCP2_ENST00000371509.4_Missense_Mutation_p.P220S|SCP2_ENST00000473584.1_3'UTR|SCP2_ENST00000407246.2_Missense_Mutation_p.P240S	NM_002979.4	NP_002970.2	P22307	NLTP_HUMAN	sterol carrier protein 2	264					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|lipid transport	mitochondrion|nucleus|peroxisomal matrix	propanoyl-CoA C-acyltransferase activity|propionyl-CoA C2-trimethyltridecanoyltransferase activity|protein binding|sterol binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	15						GACTGATTTGCCAAGCTCGTT	0.363000													17	38					0	0	1	0	0
TCL6	27004	broad.mit.edu	37	14	96136820	96136820	+	RNA	SNP	C	C	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr14:96136820C>A	ENST00000467865.1	+	0	1930				RP11-1070N10.6_ENST00000461160.1_RNA																large_intestine(1)|lung(7)	8		all_cancers(154;0.103)		Epithelial(152;0.0655)|all cancers(159;0.149)|BRCA - Breast invasive adenocarcinoma(234;0.206)|COAD - Colon adenocarcinoma(157;0.207)		CACACTGGGCCAAGAGCAGCT	0.453000			T	TRA@	T-ALL								19	16					6.44725e-10	6.68277e-10	1	1	0
KIAA2013	90231	broad.mit.edu	37	1	11983339	11983339	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr1:11983339G>A	ENST00000376572.3	-	2	1426	c.1241C>T	c.(1240-1242)cCg>cTg	p.P414L	KIAA2013_ENST00000376576.3_Missense_Mutation_p.P414L	NM_138346.2	NP_612355.1	Q8IYS2	K2013_HUMAN	KIAA2013	414						integral to membrane				endometrium(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	7	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00149)|all_lung(284;0.00189)|Breast(348;0.00586)|Colorectal(325;0.0062)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0556)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CAGCCGCCCCGGCCACAGGTT	0.642000													17	26					0	0	1	0	0
FEM1A	55527	broad.mit.edu	37	19	4793724	4793724	+	Missense_Mutation	SNP	C	C	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr19:4793724C>A	ENST00000269856.3	+	1	1997	c.1858C>A	c.(1858-1860)Ctg>Atg	p.L620M	AC005523.2_ENST00000601192.1_RNA	NM_018708.2	NP_061178.1	Q9BSK4	FEM1A_HUMAN	fem-1 homolog a (C. elegans)	620					regulation of ubiquitin-protein ligase activity	cytoplasm	binding|ubiquitin-protein ligase activity	p.L620M(1)		breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	17		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		GGCCTACGAGCTGCTGGACGA	0.607000													6	57					1	1	1	1	0
MYOM2	9172	broad.mit.edu	37	8	2048677	2048677	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr8:2048677G>A	ENST00000262113.4	+	20	2593	c.2452G>A	c.(2452-2454)Gac>Aac	p.D818N	MYOM2_ENST00000523438.1_Missense_Mutation_p.D243N	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	818	Fibronectin type-III 5.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		TCCTGCCTACGACTTGACGTT	0.602000													25	17					0	0	1	0	0
TRO	7216	broad.mit.edu	37	X	54956439	54956439	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chrX:54956439C>T	ENST00000173898.7	+	12	3394	c.3282C>T	c.(3280-3282)atC>atT	p.I1094I	TRO_ENST00000399736.1_Intron|TRO_ENST00000375041.2_Silent_p.I697I|TRO_ENST00000420798.2_Silent_p.I625I|TRO_ENST00000319167.8_Intron|TRO_ENST00000375022.4_Intron	NM_001039705.1	NP_001034794.1	Q12816	TROP_HUMAN	trophinin	1094	62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|skin(2)|urinary_tract(1)	37						GTGCACCAATCACCAACCCTG	0.577000													30	52					0	0	1	0	0
L1CAM	3897	broad.mit.edu	37	X	153137720	153137720	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chrX:153137720G>A	ENST00000370060.1	-	5	476	c.287C>T	c.(286-288)aCc>aTc	p.T96I	L1CAM_ENST00000538883.1_Missense_Mutation_p.T98I|L1CAM_ENST00000543994.1_Missense_Mutation_p.T98I|L1CAM_ENST00000361981.3_Missense_Mutation_p.T91I|L1CAM_ENST00000370057.3_Missense_Mutation_p.T96I|L1CAM_ENST00000361699.4_Missense_Mutation_p.T96I|L1CAM_ENST00000370055.1_Missense_Mutation_p.T91I	NM_001278116.1	NP_001265045.1	P32004	L1CAM_HUMAN	L1 cell adhesion molecule	96	Ig-like C2-type 1.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	81	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCCCGTGATGGTGAAGGAGCC	0.592000													52	86					0	0	1	0	0
MMRN2	79812	broad.mit.edu	37	10	88703091	88703091	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr10:88703091C>T	ENST00000372027.4	-	6	1523	c.1450G>A	c.(1450-1452)Gac>Aac	p.D484N		NM_024756.2	NP_079032.2	Q9H8L6	MMRN2_HUMAN	multimerin 2	484						extracellular space				breast(1)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|skin(1)|stomach(1)	19						TTGATGAGGTCGGCATGGCCA	0.597000													36	14					0	0	1	0	0
SLC26A7	115111	broad.mit.edu	37	8	92406163	92406163	+	Splice_Site	SNP	G	G	C			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr8:92406163G>C	ENST00000276609.3	+	18	2070		c.e18-1		SLC26A7_ENST00000523719.1_Splice_Site|SLC26A7_ENST00000309536.2_Splice_Site|SLC26A7_ENST00000520249.1_Splice_Site	NM_052832.2	NP_439897.1	Q8TE54	S26A7_HUMAN	solute carrier family 26 (anion exchanger), member 7							basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(10)|lung(26)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	50			BRCA - Breast invasive adenocarcinoma(11;0.00802)			CTTTCTTGAAGCTTCCTTGAT	0.363000													67	39					0	0	1	0	0
PRKCG	5582	broad.mit.edu	37	19	54385842	54385842	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr19:54385842G>A	ENST00000263431.3	+	1	376	c.94G>A	c.(94-96)Gaa>Aaa	p.E32K	PRKCG_ENST00000540413.1_Missense_Mutation_p.E32K|PRKCG_ENST00000536044.1_Missense_Mutation_p.E32K	NM_002739.3	NP_002730.1	P05129	KPCG_HUMAN	protein kinase C, gamma	32					activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			large_intestine(1)|lung(4)|ovary(2)|pancreas(2)|skin(1)	10	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		GGTGGTCCACGAAGTCAAGAG	0.642000													56	85					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126328204	126328204	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr4:126328204G>A	ENST00000394329.3	+	3	5490	c.5477G>A	c.(5476-5478)aGa>aAa	p.R1826K	FAT4_ENST00000335110.5_Missense_Mutation_p.R124K	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1826	Cadherin 17.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TCGGATATGAGAATTAATATC	0.473000													55	97					0	0	1	0	0
KCNJ8	3764	broad.mit.edu	37	12	21919470	21919470	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr12:21919470C>T	ENST00000240662.2	-	3	807	c.462G>A	c.(460-462)ttG>ttA	p.L154L	RP11-59N23.1_ENST00000542489.1_RNA	NM_004982.3	NP_004973.1	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 8	154						voltage-gated potassium channel complex				cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28					Levosimendan(DB00922)	CCGTGATGGCCAAAGGGCATT	0.443000													24	36					0	0	1	0	0
FOXJ2	55810	broad.mit.edu	37	12	8196560	8196560	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr12:8196560C>T	ENST00000162391.3	+	5	1636	c.491C>T	c.(490-492)tCa>tTa	p.S164L	FOXJ2_ENST00000428177.2_Missense_Mutation_p.S164L	NM_018416.2	NP_060886.1	Q9P0K8	FOXJ2_HUMAN	forkhead box J2	164					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	nucleolus|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			autonomic_ganglia(1)|large_intestine(2)|lung(6)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	16				Kidney(36;0.0944)		TCCCAAGACTCACCAGAACAG	0.542000													44	79					0	0	1	0	0
TSSC2	650368	broad.mit.edu	37	11	3427765	3427765	+	RNA	SNP	G	G	C			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr11:3427765G>C	ENST00000529482.1	+	0	882																											CACACGTCCTGCAGTGGCCTG	0.602000													4	94					0	0	1	0	0
TMEM39A	55254	broad.mit.edu	37	3	119165985	119165985	+	Missense_Mutation	SNP	T	T	C			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr3:119165985T>C	ENST00000319172.5	-	5	875	c.455A>G	c.(454-456)tAc>tGc	p.Y152C	TMEM39A_ENST00000486159.1_Intron	NM_018266.1	NP_060736.1	Q9NV64	TM39A_HUMAN	transmembrane protein 39A	152						integral to membrane				NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)	13				GBM - Glioblastoma multiforme(114;0.244)		CAGAACCATGTAGTGAATCAT	0.408000													24	44					0	0	1	0	0
CASD1	64921	broad.mit.edu	37	7	94184838	94184838	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr7:94184838C>T	ENST00000297273.4	+	18	2449	c.2162C>T	c.(2161-2163)gCg>gTg	p.A721V		NM_022900.4	NP_075051.4	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1	721						integral to membrane				NS(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	31	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			TGGCTGGCAGCGGACACAAGG	0.378000													3	44					0	0	1	0	0
ABCA9	10350	broad.mit.edu	37	17	67016572	67016572	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr17:67016572G>A	ENST00000340001.4	-	19	2768	c.2557C>T	c.(2557-2559)Cgc>Tgc	p.R853C	ABCA9_ENST00000453985.2_Missense_Mutation_p.R853C|ABCA9_ENST00000370732.2_Missense_Mutation_p.R853C	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9	853					transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					TTTAGGAAGCGAACTTTTGCT	0.398000													28	55					0	0	1	0	0
CD53	963	broad.mit.edu	37	1	111440472	111440472	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr1:111440472C>T	ENST00000271324.5	+	7	658	c.546C>T	c.(544-546)ttC>ttT	p.F182F	CD53_ENST00000429072.2_Silent_p.F123F|CD53_ENST00000497404.1_Intron	NM_000560.3|NM_001040033.1	NP_000551.1|NP_001035122.1	P19397	CD53_HUMAN	CD53 molecule	182					signal transduction	integral to membrane|plasma membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)	17		all_cancers(81;1.06e-05)|all_epithelial(167;1.95e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0264)|Colorectal(144;0.0375)|all cancers(265;0.11)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.141)|LUSC - Lung squamous cell carcinoma(189;0.144)		ATTCCAATTTCCTGTATATCG	0.378000													42	58					0	0	1	0	0
DEPDC1B	55789	broad.mit.edu	37	5	59940626	59940626	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr5:59940626G>A	ENST00000265036.5	-	5	722	c.655C>T	c.(655-657)Cat>Tat	p.H219Y	DEPDC1B_ENST00000545085.1_Missense_Mutation_p.H192Y|DEPDC1B_ENST00000453022.2_Missense_Mutation_p.H219Y	NM_018369.2	NP_060839.2	Q8WUY9	DEP1B_HUMAN	DEP domain containing 1B	219	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(2)|skin(2)	17		Lung NSC(810;0.000214)|Prostate(74;0.0147)|Breast(144;0.0991)|Ovarian(174;0.17)				TATACATTATGGATGATGAAC	0.294000													14	10					0	0	1	0	0
CYP3A5	1577	broad.mit.edu	37	7	99262788	99262788	+	Splice_Site	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr7:99262788C>T	ENST00000339843.2	-	8	1291		c.e8+1		CYP3A5_ENST00000222982.4_Splice_Site|CYP3A5_ENST00000343703.5_Splice_Site					cytochrome P450, family 3, subfamily A, polypeptide 5											NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_epithelial(64;2.77e-08)|Lung NSC(181;0.00396)|all_lung(186;0.00659)|Esophageal squamous(72;0.0166)					AGCCCACATACTTATTGAGAG	0.333000													12	15					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179517218	179517218	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr2:179517218G>A	ENST00000589042.1	-	202	39318	c.39094C>T	c.(39094-39096)Cct>Tct	p.P13032S	TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.P11525S|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.P10598S|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11388	Ig-like 86.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTTAGGAGGAGCCGCTGGC	0.388000													36	73					0	0	1	0	0
SLC24A2	25769	broad.mit.edu	37	9	19786271	19786271	+	Silent	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr9:19786271G>A	ENST00000341998.2	-	1	655	c.594C>T	c.(592-594)atC>atT	p.I198I	SLC24A2_ENST00000286344.3_Silent_p.I198I	NM_001193288.2|NM_020344.3	NP_001180217.1|NP_065077.1	Q9UI40	NCKX2_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2	198					visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity	p.I198I(1)		endometrium(3)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		TGCTGTGAGCGATAAATACCC	0.458000													26	15					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	62					0	0	1	0	0
FBXW10	10517	broad.mit.edu	37	17	18671873	18671873	+	Silent	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr17:18671873G>A	ENST00000308799.4	+	9	2037	c.1818G>A	c.(1816-1818)gtG>gtA	p.V606V	FBXW10_ENST00000395665.4_Silent_p.V577V|FBXW10_ENST00000395667.1_Silent_p.V577V|FBXW10_ENST00000301938.4_Silent_p.V577V			Q5XX13	FBW10_HUMAN	F-box and WD repeat domain containing 10	577										NS(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	42						AGGGAGCCGTGAAATGCCTGT	0.532000													21	45					0	0	1	0	0
PSG1	5669	broad.mit.edu	37	19	43376067	43376067	+	Silent	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr19:43376067G>A	ENST00000244296.2	-	3	698	c.561C>T	c.(559-561)ctC>ctT	p.L187L	PSG1_ENST00000403380.3_Intron|PSG1_ENST00000595356.1_Silent_p.L187L|PSG1_ENST00000595124.1_Intron|PSG1_ENST00000312439.6_Silent_p.L187L|PSG1_ENST00000436291.2_Silent_p.L187L	NM_006905.2	NP_008836.2			pregnancy specific beta-1-glycoprotein 1											breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30		Prostate(69;0.00682)				GAGTCATAGGGAGGCTCTGAC	0.502000													105	221					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21487828	21487828	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr18:21487828G>A	ENST00000313654.9	+	54	7185	c.6944G>A	c.(6943-6945)aGa>aAa	p.R2315K	LAMA3_ENST00000588770.1_3'UTR|LAMA3_ENST00000587184.1_Missense_Mutation_p.R650K|LAMA3_ENST00000269217.6_Missense_Mutation_p.R706K|LAMA3_ENST00000399516.3_Missense_Mutation_p.R2259K	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	2315	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GATGTGGAAAGAATTAAGGAC	0.488000													62	66					0	0	1	0	0
GALNT18	374378	broad.mit.edu	37	11	11470319	11470319	+	Silent	SNP	G	G	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr11:11470319G>T	ENST00000227756.4	-	2	811	c.400C>A	c.(400-402)Cgg>Agg	p.R134R		NM_198516.2	NP_940918.2			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18																		GGCAGGGGCCGGTCCAGGGGC	0.667000													8	38					6.40141e-05	6.5752e-05	1	1	0
FBN1	2200	broad.mit.edu	37	15	48729974	48729974	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr15:48729974C>T	ENST00000316623.5	-	51	6759	c.6304G>A	c.(6304-6306)Gaa>Aaa	p.E2102K		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	2102	TB 8.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CCATCAGGTTCCGTGGGGCAG	0.517000													22	43					0	0	1	0	0
RAG1	5896	broad.mit.edu	37	11	36594863	36594863	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr11:36594863C>T	ENST00000299440.5	+	2	121	c.9C>T	c.(7-9)gcC>gcT	p.A3A		NM_000448.2	NP_000439.1	P15918	RAG1_HUMAN	recombination activating gene 1	3	Interaction with importin alpha-1.				histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	65	all_lung(20;0.226)	all_hematologic(20;0.107)				GCATGGCAGCCTCTTTCCCAC	0.388000									Familial Hemophagocytic Lymphohistiocytosis				46	75					0	0	1	0	0
CABS1	85438	broad.mit.edu	37	4	71201637	71201637	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr4:71201637G>A	ENST00000273936.4	+	1	940	c.881G>A	c.(880-882)gGa>gAa	p.G294E		NM_033122.3	NP_149113.3	Q96KC9	CABS1_HUMAN	calcium-binding protein, spermatid-specific 1	294						flagellum	calcium ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(4)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						ACTACCGAGGGAGCCAGTATT	0.423000													24	57					0	0	1	0	0
CSH2	1443	broad.mit.edu	37	17	61950700	61950700	+	Splice_Site	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr17:61950700C>T	ENST00000336844.5	-	2	162		c.e2-1		CSH2_ENST00000560142.1_Splice_Site|CSH2_ENST00000345366.7_Splice_Site|CSH2_ENST00000392886.2_Splice_Site	NM_022644.3	NP_072170.1	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 2						female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding			endometrium(2)|large_intestine(1)|lung(3)	6						GTCCGGGAGCCTGGGGAGAAA	0.602000													8	29					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139145027	139145027	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr8:139145027C>T	ENST00000395297.1	-	20	4200	c.4030G>A	c.(4030-4032)Gaa>Aaa	p.E1344K		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1344										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TTGATCATTTCTGCATAAACT	0.493000										HNSCC(54;0.14)			335	147					0	0	1	0	0
LPHN1	22859	broad.mit.edu	37	19	14262131	14262131	+	Missense_Mutation	SNP	C	C	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr19:14262131C>A	ENST00000340736.6	-	24	4276	c.3979G>T	c.(3979-3981)Ggt>Tgt	p.G1327C	CTB-55O6.12_ENST00000588658.1_RNA|CTB-55O6.12_ENST00000588387.1_RNA|LPHN1_ENST00000361434.3_Missense_Mutation_p.G1322C	NM_001008701.2	NP_001008701.1	O94910	LPHN1_HUMAN	latrophilin 1	1327					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						CGGTCAGCACCCCCGGGCCCG	0.721000													4	4					0.00909568	0.00925883	1	1	0
FBN1	2200	broad.mit.edu	37	15	48729975	48729975	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr15:48729975C>T	ENST00000316623.5	-	51	6758	c.6303G>A	c.(6301-6303)acG>acA	p.T2101T		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	2101	TB 8.		T -> M.		heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CATCAGGTTCCGTGGGGCAGA	0.522000													22	43					0	0	1	0	0
DARC	2532	broad.mit.edu	37	1	159175671	159175671	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr1:159175671G>A	ENST00000537147.1	+	3	1285	c.442G>A	c.(442-444)Ggg>Agg	p.G148R	DARC_ENST00000368121.2_Missense_Mutation_p.G150R|DARC_ENST00000368122.2_Missense_Mutation_p.G148R			Q16570	DUFFY_HUMAN	Duffy blood group, atypical chemokine receptor	148					defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			large_intestine(2)|lung(1)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	8	all_hematologic(112;0.0429)					TTTGCTGCTAGGGTGCCATGC	0.642000													9	21					0	0	1	0	0
MALT1	10892	broad.mit.edu	37	18	56376664	56376664	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr18:56376664C>T	ENST00000348428.3	+	5	962	c.704C>T	c.(703-705)tCc>tTc	p.S235F	MALT1_ENST00000345724.3_Missense_Mutation_p.S235F|RP11-126O1.4_ENST00000588835.1_RNA	NM_006785.2|NM_173844.1	NP_006776.1|NP_776216.1	Q9UDY8	MALT1_HUMAN	mucosa associated lymphoid tissue lymphoma translocation gene 1	235	Ig-like C2-type 2.				activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity			central_nervous_system(1)|large_intestine(7)|lung(1)|ovary(2)|skin(1)	12						GAACCAACTTCCCAAAAGCTG	0.363000			T	BIRC3	MALT								32	38					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9072091	9072091	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr19:9072091G>A	ENST00000397910.4	-	3	15558	c.15355C>T	c.(15355-15357)Cct>Tct	p.P5119S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5121	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTTATAGAAGGAAAAATTTCC	0.453000													11	29					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17073037	17073037	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr22:17073037G>A	ENST00000359963.3	-	1	663	c.404C>T	c.(403-405)gCc>gTc	p.A135V		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	135					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CGTGGCGTAGGCCTCCCGGAG	0.657000													41	14					0	0	1	0	0
FCGR2A	2212	broad.mit.edu	37	1	161479832	161479832	+	Missense_Mutation	SNP	T	T	A	rs141094947		TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr1:161479832T>A	ENST00000271450.6	+	4	625	c.587T>A	c.(586-588)tTc>tAc	p.F196Y	FCGR2A_ENST00000367972.4_Missense_Mutation_p.F195Y|FCGR2A_ENST00000467525.1_3'UTR	NM_001136219.1|NM_021642.3	NP_001129691.1|NP_067674.2	P12318	FCG2A_HUMAN	Fc fragment of IgG, low affinity IIa, receptor (CD32)	196	Ig-like C2-type 2.					integral to membrane|plasma membrane	IgG binding|receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(2)|large_intestine(2)|lung(11)|ovary(1)	19	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TACACGCTGTTCTCATCCAAG	0.527000													5	89					0	0	1	0	0
FEZ2	9637	broad.mit.edu	37	2	36808483	36808483	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr2:36808483G>A	ENST00000379245.4	-	4	632	c.584C>T	c.(583-585)tCc>tTc	p.S195F	FEZ2_ENST00000305852.7_Missense_Mutation_p.S24F|FEZ2_ENST00000405912.3_Missense_Mutation_p.S195F	NM_001042548.1	NP_001036013.1	Q9UHY8	FEZ2_HUMAN	fasciculation and elongation protein zeta 2 (zygin II)	195					axon guidance|signal transduction		protein binding			breast(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|urinary_tract(1)	7		all_hematologic(82;0.21)				AATTTCCTGGGAAAGCATTGA	0.418000													60	123					0	0	1	0	0
LHCGR	3973	broad.mit.edu	37	2	48915278	48915278	+	Missense_Mutation	SNP	A	A	G			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr2:48915278A>G	ENST00000294954.7	-	11	1679	c.1658T>C	c.(1657-1659)gTt>gCt	p.V553A	LHCGR_ENST00000405626.1_Missense_Mutation_p.V526A|LHCGR_ENST00000401907.1_Splice_Site_p.L316_splice|LHCGR_ENST00000344775.3_Missense_Mutation_p.V491A|LHCGR_ENST00000403273.1_3'UTR|STON1-GTF2A1L_ENST00000402114.2_Intron	NM_000233.3	NP_000224.2	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	553					male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(3)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	56		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	TGGGTTTCGAACTGCAAAATA	0.373000													33	61					0	0	1	0	0
GSG1	83445	broad.mit.edu	37	12	13241778	13241778	+	Missense_Mutation	SNP	C	C	T	rs148537880		TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr12:13241778C>T	ENST00000396302.3	-	3	589	c.391G>A	c.(391-393)Gaa>Aaa	p.E131K	GSG1_ENST00000432710.2_Intron|GSG1_ENST00000537302.1_Intron|GSG1_ENST00000351606.6_Missense_Mutation_p.E167K|GSG1_ENST00000337630.6_Intron|GSG1_ENST00000457134.2_Intron|GSG1_ENST00000324458.8_Intron|GSG1_ENST00000396310.2_Intron	NM_031289.3	NP_112579.2	Q2KHT4	GSG1_HUMAN	germ cell associated 1	0						endoplasmic reticulum membrane|integral to membrane				endometrium(1)|large_intestine(3)|lung(4)|skin(1)|urinary_tract(1)	10		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		GTGGCAAATTCCAGTAGTCCT	0.537000													19	39					0	0	1	0	0
RP11-24M17.5	0	broad.mit.edu	37	15	76072993	76072993	+	RNA	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr15:76072993G>A	ENST00000395215.3	+	0	382																											AAAACCAACAGTGAAATACAC	0.483000													32	50					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34149758	34149758	+	Missense_Mutation	SNP	G	G	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chrX:34149758G>T	ENST00000346193.3	-	1	689	c.638C>A	c.(637-639)cCg>cAg	p.P213Q		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	213	Pro-rich.									NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						GGGAGGCTCCGGGCTTAGATG	0.632000													34	76					8.16277e-20	8.53894e-20	1	1	0
NYNRIN	57523	broad.mit.edu	37	14	24884562	24884562	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr14:24884562C>T	ENST00000382554.3	+	9	3925	c.3607C>T	c.(3607-3609)Cag>Tag	p.Q1203*		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1203					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						CCAGGGCCCCCAGTCAGGGGG	0.622000													48	31					0	0	1	0	0
DDX39A	10212	broad.mit.edu	37	19	14522376	14522376	+	Missense_Mutation	SNP	A	A	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr19:14522376A>T	ENST00000242776.4	-	4	472	c.371T>A	c.(370-372)cTg>cAg	p.L124Q	DDX39A_ENST00000454233.2_Missense_Mutation_p.L124Q|DDX39A_ENST00000592927.1_5'UTR	NM_005804.3	NP_005795.2	O00148	DX39A_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A	124	Helicase ATP-binding.				mRNA export from nucleus|nuclear mRNA splicing, via spliceosome	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			NS(1)|endometrium(5)|kidney(1)|lung(2)|ovary(1)|pancreas(1)	11						CTGGAAGGCCAGCTCCCTCGT	0.572000													29	50					0	0	1	0	0
TM7SF3	51768	broad.mit.edu	37	12	27133557	27133557	+	Silent	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr12:27133557G>A	ENST00000343028.4	-	8	1203	c.978C>T	c.(976-978)atC>atT	p.I326I	TM7SF3_ENST00000542667.1_Intron	NM_016551.2	NP_057635.1	Q9NS93	TM7S3_HUMAN	transmembrane 7 superfamily member 3	326	Phe-rich.					integral to membrane|plasma membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	18	Colorectal(261;0.0847)					ATCCCATGATGATAAAGCCTA	0.338000													19	32					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179594659	179594659	+	Silent	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr2:179594659G>A	ENST00000589042.1	-	63	18545	c.18321C>T	c.(18319-18321)ttC>ttT	p.F6107F	TTN_ENST00000591111.1_Silent_p.F5790F|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Silent_p.F4863F|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5790	Ig-like 42.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTTCTTAATGAATTGAGGAG	0.428000													7	7					0	0	1	0	0
LRRC3B	116135	broad.mit.edu	37	3	26751472	26751472	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr3:26751472C>T	ENST00000396641.2	+	2	901	c.309C>T	c.(307-309)atC>atT	p.I103I	LRRC3B_ENST00000456208.2_Silent_p.I103I|LRRC3B_ENST00000417744.1_Silent_p.I103I	NM_052953.2	NP_443185.1	Q96PB8	LRC3B_HUMAN	leucine rich repeat containing 3B	103						integral to membrane		p.I103I(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|skin(4)	21						TTGAGTTTATCGATGAGCATG	0.418000													22	32					0	0	1	0	0
OR2M3	127062	broad.mit.edu	37	1	248367272	248367272	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr1:248367272C>T	ENST00000456743.1	+	1	941	c.903C>T	c.(901-903)ttC>ttT	p.F301F		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	301					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CCAGAGCATTCATGAAGATCT	0.428000													41	73					0	0	1	0	0
L1CAM	3897	broad.mit.edu	37	X	153132318	153132318	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chrX:153132318C>T	ENST00000370060.1	-	19	2406	c.2217G>A	c.(2215-2217)cgG>cgA	p.R739R	L1CAM_ENST00000538883.1_Silent_p.R741R|L1CAM_ENST00000543994.1_Silent_p.R741R|L1CAM_ENST00000361981.3_Silent_p.R734R|L1CAM_ENST00000370057.3_Silent_p.R739R|L1CAM_ENST00000361699.4_Silent_p.R739R|L1CAM_ENST00000370055.1_Silent_p.R734R	NM_001278116.1	NP_001265045.1	P32004	L1CAM_HUMAN	L1 cell adhesion molecule	739	Fibronectin type-III 2.		R -> W.		axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	81	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGTCCATCCACCGGAGCGGCT	0.647000													19	22					0	0	1	0	0
SLC6A14	11254	broad.mit.edu	37	X	115585523	115585523	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chrX:115585523C>T	ENST00000371900.4	+	10	1407	c.1319C>T	c.(1318-1320)cCc>cTc	p.P440L		NM_007231.3	NP_009162.1	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid transporter), member 14	440					cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	23					L-Proline(DB00172)	GATTTATTTCCCAAAGTGATG	0.388000													22	28					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31323520	31323520	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr18:31323520C>T	ENST00000269197.5	+	12	3708	c.3708C>T	c.(3706-3708)gtC>gtT	p.V1236V		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1236	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						AAAATTCTGTCCCTGTATCTG	0.378000													21	54					0	0	1	0	0
SLC27A2	11001	broad.mit.edu	37	15	50494781	50494781	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr15:50494781C>T	ENST00000267842.5	+	3	1018	c.786C>T	c.(784-786)atC>atT	p.I262I	SLC27A2_ENST00000380902.4_Intron|SLC27A2_ENST00000544960.1_Silent_p.I27I	NM_003645.3	NP_003636.2	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid transporter), member 2	262					bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			NS(1)|breast(2)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		TCATCTATATCACTCTGCCCT	0.453000													50	86					0	0	1	0	0
PSAP	5660	broad.mit.edu	37	10	73590984	73590984	+	Nonsense_Mutation	SNP	T	T	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr10:73590984T>A	ENST00000394936.3	-	4	421	c.274A>T	c.(274-276)Aag>Tag	p.K92*	PSAP_ENST00000394934.1_Nonsense_Mutation_p.K92*			P07602	SAP_HUMAN	prosaposin	92	Saposin B-type 1.				glycosphingolipid metabolic process|lipid transport|platelet activation|platelet degranulation	extracellular space|Golgi apparatus|integral to membrane|lysosomal lumen	enzyme activator activity|lipid binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	13						TCACAGGTCTTCTCCAAGTAA	0.498000													22	9					0	0	1	0	0
VN1R2	317701	broad.mit.edu	37	19	53761967	53761967	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr19:53761967C>T	ENST00000341702.3	+	1	423	c.339C>T	c.(337-339)ttC>ttT	p.F113F		NM_173856.2	NP_776255.2	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	113					response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(134;0.00301)		ATTATATGTTCCTTTACTTTA	0.433000													20	25					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16902873	16902873	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr1:16902873G>A	ENST00000430580.2	-	19	2895	c.2008C>T	c.(2008-2010)Cag>Tag	p.Q670*	NBPF1_ENST00000432949.1_Nonsense_Mutation_p.Q128*|NBPF1_ENST00000287968.8_Nonsense_Mutation_p.Q35*	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	670						cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		AGGAGGGCCTGGAGATGCTGA	0.547000													35	846					0	0	1	0	0
CDR2	1039	broad.mit.edu	37	16	22358417	22358417	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr16:22358417G>A	ENST00000268383.2	-	5	1541	c.1234C>T	c.(1234-1236)Ccc>Tcc	p.P412S		NM_001802.1	NP_001793.1	Q01850	CDR2_HUMAN	cerebellar degeneration-related protein 2, 62kDa	412						nucleus	protein binding			endometrium(3)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(1)	11				GBM - Glioblastoma multiforme(48;0.0188)		GAACTCACGGGCTCTGGGTTG	0.522000													3	46					0	0	1	0	0
PRSS58	136541	broad.mit.edu	37	7	141955085	141955085	+	Missense_Mutation	SNP	C	C	T	rs147205406		TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr7:141955085C>T	ENST00000552471.1	-	3	545	c.226G>A	c.(226-228)Gaa>Aaa	p.E76K	PRSS58_ENST00000547058.2_Missense_Mutation_p.E76K			Q8IYP2	PRS58_HUMAN	protease, serine, 58	76	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(2)|skin(2)	19						AGATGCTTTTCATTAGAGTCT	0.408000													40	54					0	0	1	0	0
SCRIB	23513	broad.mit.edu	37	8	144887330	144887330	+	Missense_Mutation	SNP	G	G	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr8:144887330G>T	ENST00000356994.2	-	19	2628	c.2622C>A	c.(2620-2622)ttC>ttA	p.F874L	SCRIB_ENST00000320476.3_Missense_Mutation_p.F874L|SCRIB_ENST00000377533.3_Missense_Mutation_p.F793L	NM_182706.4	NP_874365.3	Q14160	SCRIB_HUMAN	scribbled planar cell polarity protein	874	Interaction with ARHGEF7.|PDZ 2.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CAGCAATGCTGAAGCCCAGCC	0.726000													13	53					4.14922e-12	4.32052e-12	1	1	0
SPAG17	200162	broad.mit.edu	37	1	118581996	118581996	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr1:118581996C>T	ENST00000336338.5	-	23	3303	c.3238G>A	c.(3238-3240)Gaa>Aaa	p.E1080K		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1080						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TTCACAATTTCCTTAGGGTCA	0.383000													9	27					0	0	1	0	0
MPEG1	219972	broad.mit.edu	37	11	58980174	58980174	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr11:58980174C>T	ENST00000361050.3	-	1	250	c.165G>A	c.(163-165)cgG>cgA	p.R55R		NM_001039396.1	NP_001034485.1	Q2M385	MPEG1_HUMAN	macrophage expressed 1	55	MACPF.					integral to membrane				NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(21)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		all_epithelial(135;0.125)				TGTCCACATTCCGCAGATTGT	0.488000													101	156					0	0	1	0	0
ESX1	80712	broad.mit.edu	37	X	103495543	103495543	+	Missense_Mutation	SNP	C	C	T	rs144948361		TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chrX:103495543C>T	ENST00000372588.4	-	4	670	c.587G>A	c.(586-588)cGa>cAa	p.R196Q		NM_153448.3	NP_703149.1	Q8N693	ESX1_HUMAN	ESX homeobox 1	196					negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(10)|lung(12)|ovary(1)|skin(2)	27						CCTCTGATTTCGTTTCCACTT	0.433000													97	149					0	0	1	0	0
SLC9A2	6549	broad.mit.edu	37	2	103300793	103300793	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr2:103300793C>T	ENST00000233969.2	+	5	1565	c.1423C>T	c.(1423-1425)Ctg>Ttg	p.L475L		NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	475						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						TGTCTTCATTCTGGTAAGTAG	0.388000													57	85					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75265550	75265550	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr14:75265550C>T	ENST00000325680.7	+	5	3674	c.3550C>T	c.(3550-3552)Cac>Tac	p.H1184Y	YLPM1_ENST00000552421.1_Intron|YLPM1_ENST00000238571.3_Missense_Mutation_p.H989Y	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	989	Arg-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		GTATCCATATCACCGGGATGA	0.493000													28	10					0	0	1	0	0
KRTAP10-11	386678	broad.mit.edu	37	21	46067170	46067170	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr21:46067170C>T	ENST00000334670.8	+	1	840	c.795C>T	c.(793-795)tcC>tcT	p.S265S	TSPEAR_ENST00000323084.4_Intron	NM_198692.2	NP_941965.2	P60411	KR109_HUMAN	keratin associated protein 10-11	259						keratin filament		p.S265S(1)		NS(1)|endometrium(1)|large_intestine(1)|lung(6)|ovary(2)|prostate(1)	12						CCTGCCAGTCCAGCTGCTGCC	0.692000													44	87					0	0	1	0	0
BET1	10282	broad.mit.edu	37	7	93625629	93625629	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr7:93625629G>A	ENST00000222547.3	-	3	307	c.149C>T	c.(148-150)tCc>tTc	p.S50F	BET1_ENST00000433727.1_Missense_Mutation_p.S50F|BET1_ENST00000425626.1_Missense_Mutation_p.S50F|AC006378.2_ENST00000426193.2_RNA|AC006378.2_ENST00000426634.1_RNA|BET1_ENST00000471446.1_5'UTR	NM_005868.4	NP_005859.1	O15155	BET1_HUMAN	Bet1 golgi vesicular membrane trafficking protein	50	t-SNARE coiled-coil homology.				ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	protein binding			large_intestine(2)|lung(1)|prostate(1)|skin(1)	5	all_cancers(62;2.22e-10)|all_epithelial(64;1.38e-09)|Lung NSC(181;0.218)	Breast(660;0.000162)|Ovarian(593;0.000626)	STAD - Stomach adenocarcinoma(171;0.000967)			TATTTCAATGGAAAGCTATAA	0.279000													28	86					0	0	1	0	0
CRISP3	10321	broad.mit.edu	37	6	49696524	49696524	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr6:49696524C>T	ENST00000433368.2	-	8	795	c.726G>A	c.(724-726)ttG>ttA	p.L242L	CRISP3_ENST00000423399.2_Silent_p.L129L|CRISP3_ENST00000393666.1_Silent_p.L219L|CRISP3_ENST00000263045.4_Silent_p.L232L|CRISP3_ENST00000371159.4_Silent_p.L250L	NM_001190986.1	NP_001177915.1	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3	219					innate immune response	proteinaceous extracellular matrix|specific granule				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(14)|skin(6)|upper_aerodigestive_tract(1)	27	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			ATGTGAGCTTCAAACTTTTAC	0.363000													24	56					0	0	1	0	0
BCORL1	63035	broad.mit.edu	37	X	129147333	129147333	+	Missense_Mutation	SNP	C	C	G			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chrX:129147333C>G	ENST00000540052.1	+	3	629	c.585C>G	c.(583-585)aaC>aaG	p.N195K	BCORL1_ENST00000359304.2_Missense_Mutation_p.N195K|BCORL1_ENST00000218147.7_Missense_Mutation_p.N195K|BCORL1_ENST00000303743.5_Missense_Mutation_p.N195K	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	195					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						TTACCACTAACTTCAGTCCTC	0.582000													98	160					0	0	1	0	0
SLC22A10	387775	broad.mit.edu	37	11	63072257	63072257	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr11:63072257G>A	ENST00000332793.6	+	9	1496	c.1494G>A	c.(1492-1494)tgG>tgA	p.W498*	SLC22A10_ENST00000544661.1_3'UTR|SLC22A10_ENST00000526800.1_Intron|SLC22A10_ENST00000535888.1_Intron|SLC22A10_ENST00000525620.1_Intron	NM_001039752.3	NP_001034841.3	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	498						integral to membrane	transmembrane transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CTTTGCCATGGATCATTTATG	0.458000													29	64					0	0	1	0	0
CELA2A	63036	broad.mit.edu	37	1	15793996	15793996	+	Missense_Mutation	SNP	T	T	G			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr1:15793996T>G	ENST00000359621.4	+	7	780	c.755T>G	c.(754-756)tTc>tGc	p.F252C	CELA2B_ENST00000494280.1_3'UTR	NM_033440.2	NP_254275.1	P08217	CEL2A_HUMAN	chymotrypsin-like elastase family, member 2A	252	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(2)|prostate(1)	16						CCCTCCGTCTTCACGCGGGTC	0.622000													47	63					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232561550	232561550	+	Missense_Mutation	SNP	G	G	A	rs150962063		TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr1:232561550G>A	ENST00000366630.1	-	17	4773	c.4415C>T	c.(4414-4416)tCg>tTg	p.S1472L	SIPA1L2_ENST00000308942.4_Missense_Mutation_p.S546L|SIPA1L2_ENST00000262861.4_Missense_Mutation_p.S1472L			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	1472					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity	p.S1472L(1)		NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CCCATAGAACGAAAACTAGGG	0.507000													13	35					0	0	1	0	0
APBB1IP	54518	broad.mit.edu	37	10	26849057	26849057	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr10:26849057C>T	ENST00000376236.4	+	12	1634	c.1179C>T	c.(1177-1179)tcC>tcT	p.S393S		NM_019043.3	NP_061916.3	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	393	PH.				blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(27)|skin(7)|upper_aerodigestive_tract(1)	45						AGAAGGAGTCCCAGTATATCA	0.453000													45	81					0	0	1	0	0
OR4C6	219432	broad.mit.edu	37	11	55433488	55433488	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr11:55433488C>T	ENST00000314259.3	+	1	875	c.846C>T	c.(844-846)ccC>ccT	p.P282P		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	282					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						TGTTAAATCCCTTGATCTATA	0.458000													31	49					0	0	1	0	0
SS18	6760	broad.mit.edu	37	18	23615801	23615801	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr18:23615801C>T	ENST00000415083.2	-	8	1022	c.967G>A	c.(967-969)Gaa>Aaa	p.E323K	SS18_ENST00000542420.2_Missense_Mutation_p.E300K|SS18_ENST00000542743.1_Intron|SS18_ENST00000545952.1_Intron|SS18_ENST00000539849.1_Missense_Mutation_p.E241K|SS18_ENST00000269137.7_Intron	NM_001007559.1|NM_005637.2	NP_001007560.1|NP_005628.2	Q15532	SSXT_HUMAN	synovial sarcoma translocation, chromosome 18	323	Gln-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding		SS18/SSX2(706)|SS18/SSX1(1169)|SS18/SSX4(12)	endometrium(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(1)	19	all_cancers(21;0.000194)|Lung NSC(5;0.000413)|all_lung(6;0.00118)|Ovarian(20;0.124)					ATACCTCCTTCGTAGTAATGT	0.398000			T	"""SSX1,  SSX2"""	synovial sarcoma								4	10					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128498177	128498177	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr7:128498177C>T	ENST00000325888.8	+	47	8157	c.7896C>T	c.(7894-7896)tcC>tcT	p.S2632S	FLNC_ENST00000346177.6_Silent_p.S2599S|RP11-309L24.2_ENST00000469965.1_RNA	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	2632	Interaction with INPPL1.|Self-association site, tail (By similarity).				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CCAAGTTCTCCTCAGATGCCA	0.612000													19	26					0	0	1	0	0
B4GALNT3	283358	broad.mit.edu	37	12	665929	665929	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr12:665929C>T	ENST00000266383.5	+	15	2290	c.2277C>T	c.(2275-2277)aaC>aaT	p.N759N		NM_173593.3	NP_775864.3	Q6L9W6	B4GN3_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 3	759						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			ACCCACACAACCGTAGGAGAC	0.642000													17	29					0	0	1	0	0
IL18RAP	8807	broad.mit.edu	37	2	103067483	103067483	+	Splice_Site	SNP	T	T	C			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr2:103067483T>C	ENST00000264260.2	+	11	1973		c.e11+2		IL18RAP_ENST00000409369.1_Splice_Site	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein						cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(4)	37						CAGGAGGAGGTAAGTCCAACA	0.408000													16	30					0	0	1	0	0
OR8J3	81168	broad.mit.edu	37	11	55904316	55904316	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr11:55904316C>T	ENST00000301529.1	-	1	878	c.879G>A	c.(877-879)agG>agA	p.R293R		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	293					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					CATCATTATTCCTCAGGCTGT	0.358000													23	51					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179403940	179403940	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr2:179403940C>T	ENST00000589042.1	-	353	98946	c.98722G>A	c.(98722-98724)Gat>Aat	p.D32908N	TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D31267N|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.D24035N|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.D30340N|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D23843N|TTN_ENST00000359218.5_Missense_Mutation_p.D23968N|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000586452.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	31267							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.D23968N(1)|p.D30338N(1)|p.D23843N(1)|p.D24035N(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGGTTACATCGAGTACTTCT	0.443000													20	23					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				25	53					0	0	1	0	0
LOC220729	220729	broad.mit.edu	37	3	197348739	197348739	+	RNA	SNP	G	G	C			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr3:197348739G>C	ENST00000418868.1	-	0	520					NR_003266.2																						TAATTTTCTAGCTGTGAAAGA	0.398000													3	128					0	0	1	0	0
HPR	3250	broad.mit.edu	37	16	72107867	72107867	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr16:72107867G>A	ENST00000540303.2	+	2	114	c.82G>A	c.(82-84)Gat>Aat	p.D28N	HPR_ENST00000228226.8_Missense_Mutation_p.D65N|HPR_ENST00000561690.1_Missense_Mutation_p.D28N|HPR_ENST00000356967.5_Missense_Mutation_p.D28N	NM_020995.3	NP_066275.3	P00739	HPTR_HUMAN	haptoglobin-related protein	28					proteolysis	spherical high-density lipoprotein particle	hemoglobin binding|serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|stomach(1)|urinary_tract(2)	20		Ovarian(137;0.125)				TGATGTCACGGATATTTCAGG	0.507000													40	70					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21106623	21106623	+	Splice_Site	SNP	T	T	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr10:21106623T>A	ENST00000377122.4	-	21	2452		c.e21-2		NEBL_ENST00000417816.2_Intron|NEBL_ENST00000377159.4_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette						regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						ATATTTTACCTAAGAAGGATA	0.383000													24	35					0	0	1	0	0
CCDC103	388389	broad.mit.edu	37	17	42980074	42980074	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr17:42980074C>T	ENST00000417826.2	+	4	713	c.618C>T	c.(616-618)tcC>tcT	p.S206S	FAM187A_ENST00000331733.4_5'UTR|FAM187A_ENST00000412523.2_Intron|CCDC103_ENST00000410006.2_Silent_p.S206S	NM_001258399.1|NM_213607.2	NP_001245328.1|NP_998772.1	Q8IW40	CC103_HUMAN	coiled-coil domain containing 103	206										endometrium(1)|kidney(1)|large_intestine(3)|prostate(1)|skin(1)	7		Prostate(33;0.109)				ACCCCAGATCCGTGAAGGAGG	0.632000													13	22					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73680996	73680996	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr2:73680996C>T	ENST00000264448.6	+	8	7450	c.7339C>T	c.(7339-7341)Cca>Tca	p.P2447S	ALMS1_ENST00000409009.1_Missense_Mutation_p.P2405S|ALMS1_ENST00000377715.1_Missense_Mutation_p.P2447S	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	2447					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						AAACTTCTTTCCATATGTTTC	0.448000													18	32					0	0	1	0	0
CYP2S1	29785	broad.mit.edu	37	19	41712370	41712370	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr19:41712370C>T	ENST00000310054.4	+	9	1708	c.1492C>T	c.(1492-1494)Cac>Tac	p.H498Y	CYP2S1_ENST00000542619.1_Missense_Mutation_p.H223Y	NM_030622.6	NP_085125.1	Q96SQ9	CP2S1_HUMAN	cytochrome P450, family 2, subfamily S, polypeptide 1	498					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity			breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(2)	14						CACTGACCTTCACTCCACCAC	0.612000													61	92					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96580369	96580369	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr10:96580369C>T	ENST00000371321.3	+	6	1018	c.936C>T	c.(934-936)ctC>ctT	p.L312L	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	312					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	CTCTCCTTCTCCTGCTGAAGC	0.453000													48	24					0	0	1	0	0
SIRPB1	10326	broad.mit.edu	37	20	1552515	1552515	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr20:1552515C>T	ENST00000381605.4	-	3	666	c.602G>A	c.(601-603)gGa>gAa	p.G201E	SIRPB1_ENST00000262929.5_Intron|RP4-576H24.4_ENST00000564763.1_Intron|SIRPB1_ENST00000381603.3_Intron	NM_006065.3	NP_006056.2	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	201	Ig-like C1-type 1.				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						CACACTGTCTCCTGCGGGGTC	0.557000													69	101					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70512851	70512851	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr14:70512851G>A	ENST00000381269.2	-	8	3350	c.2597C>T	c.(2596-2598)aCc>aTc	p.T866I	SLC8A3_ENST00000394330.2_Missense_Mutation_p.T223I|SLC8A3_ENST00000533541.1_3'UTR|SLC8A3_ENST00000356921.2_Missense_Mutation_p.T860I|SLC8A3_ENST00000534137.1_Missense_Mutation_p.T863I|SLC8A3_ENST00000357887.3_Missense_Mutation_p.T864I|SLC8A3_ENST00000528359.1_Missense_Mutation_p.T864I|SLC8A3_ENST00000216568.7_Missense_Mutation_p.T237I	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	866					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		GGTGAAGAGGGTGACGGAGAA	0.647000											OREG0022773	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	11					0	0	1	0	0
XKR4	114786	broad.mit.edu	37	8	56436410	56436410	+	Missense_Mutation	SNP	G	G	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr8:56436410G>T	ENST00000327381.5	+	3	1677	c.1577G>T	c.(1576-1578)tGt>tTt	p.C526F		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	526						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			TCACCAAGTTGTGCTTGTGAG	0.532000													34	152					3.09479e-21	3.25239e-21	1	1	0
KDR	3791	broad.mit.edu	37	4	55972864	55972864	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr4:55972864C>T	ENST00000263923.4	-	11	1821	c.1526G>A	c.(1525-1527)gGa>gAa	p.G509E		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	509	Ig-like C2-type 5.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TTTGTTTTTTCCTTCAATTAG	0.323000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			10	22					0	0	1	0	0
APLNR	187	broad.mit.edu	37	11	57003456	57003456	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr11:57003456C>T	ENST00000606794.1	-	1	1219	c.1023G>A	c.(1021-1023)gaG>gaA	p.E341E		NM_005161.4	NP_005152.1	P35414	APJ_HUMAN	apelin receptor	341						integral to plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						TGGCTGACTTCTCCCCACTGC	0.637000													29	43					0	0	1	0	0
VGLL4	9686	broad.mit.edu	37	3	11600050	11600050	+	Missense_Mutation	SNP	A	A	G			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr3:11600050A>G	ENST00000273038.3	-	6	1218	c.853T>C	c.(853-855)Tcc>Ccc	p.S285P	VGLL4_ENST00000404339.1_Missense_Mutation_p.S290P|VGLL4_ENST00000451674.2_Missense_Mutation_p.S205P|VGLL4_ENST00000424529.2_Missense_Mutation_p.S201P|VGLL4_ENST00000413604.1_Missense_Mutation_p.S226P|VGLL4_ENST00000430365.2_Missense_Mutation_p.S291P	NM_014667.2	NP_055482.2	Q14135	VGLL4_HUMAN	vestigial like 4 (Drosophila)	285					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|endometrium(1)|large_intestine(1)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10				LUSC - Lung squamous cell carcinoma(1;0.089)|Lung(1;0.111)		ACAGAGGGGGAGTGACTGTGG	0.577000													3	99					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73063804	73063804	+	RNA	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chrX:73063804G>A	ENST00000429829.1	-	0	8784					NR_001564.2																						GCCTTGGAGGGAAACAGTATA	0.383000													11	16					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152283903	152283903	+	Silent	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr1:152283903G>A	ENST00000368799.1	-	3	3494	c.3459C>T	c.(3457-3459)tcC>tcT	p.S1153S	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1153	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGAGTGCCTGGAGCTGTCTC	0.597000									Ichthyosis				234	421					0	0	1	0	0
SERPINB2	5055	broad.mit.edu	37	18	61569004	61569004	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr18:61569004C>T	ENST00000457692.1	+	7	899	c.566C>T	c.(565-567)tCt>tTt	p.S189F	SERPINB2_ENST00000299502.4_Missense_Mutation_p.S189F|SERPINB2_ENST00000482254.1_3'UTR	NM_001143818.1	NP_001137290.1	P05120	PAI2_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 2	189					anti-apoptosis|blood coagulation|fibrinolysis|regulation of proteolysis	extracellular space|Golgi apparatus|plasma membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|liver(1)|lung(12)|prostate(2)|skin(2)|stomach(1)	32		Esophageal squamous(42;0.131)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)|Urokinase(DB00013)	CCTGAAGGTTCTGTAGATGGG	0.368000													23	53					0	0	1	0	0
INTS9	55756	broad.mit.edu	37	8	28625822	28625822	+	Silent	SNP	A	A	G			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr8:28625822A>G	ENST00000416984.2	-	16	2114	c.1755T>C	c.(1753-1755)atT>atC	p.I585I	INTS9_ENST00000521777.1_Silent_p.I582I|INTS9_ENST00000521022.1_Silent_p.I606I|INTS9_ENST00000397363.4_Silent_p.I500I	NM_001145159.2	NP_001138631.1	Q9NV88	INT9_HUMAN	integrator complex subunit 9	606					snRNA processing	integrator complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|pancreas(2)|prostate(1)|urinary_tract(2)	19		Ovarian(32;0.0439)		KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.152)		CCTCCACCTTAATATCACTGA	0.507000													98	45					0	0	1	0	0
CCDC62	84660	broad.mit.edu	37	12	123282714	123282714	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr12:123282714C>T	ENST00000253079.6	+	8	1288	c.944C>T	c.(943-945)tCa>tTa	p.S315L	CCDC62_ENST00000537566.1_Missense_Mutation_p.S76L|CCDC62_ENST00000392441.4_Missense_Mutation_p.S315L|CCDC62_ENST00000392440.2_Missense_Mutation_p.S76L	NM_201435.4	NP_958843.2	Q6P9F0	CCD62_HUMAN	coiled-coil domain containing 62	315						cytoplasm|nucleus				breast(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(1)	20	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.51e-06)|Epithelial(86;2.65e-05)|BRCA - Breast invasive adenocarcinoma(302;0.206)		ATGTATGACTCAAAGATGGAG	0.343000													10	10					0	0	1	0	0
IKBKE	9641	broad.mit.edu	37	1	206647678	206647678	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr1:206647678C>T	ENST00000367120.3	+	4	465	c.92C>T	c.(91-93)tCc>tTc	p.S31F	IKBKE_ENST00000537984.1_5'UTR|IKBKE_ENST00000462698.1_Intron	NM_001193322.1|NM_014002.3	NP_001180251.1|NP_054721.1	Q14164	IKKE_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	31	Protein kinase.				DNA damage response, signal transduction resulting in induction of apoptosis|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane|PML body	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(13)|ovary(3)|skin(2)	32	Breast(84;0.137)					TGGCAGAAATCCGGAGAGCTG	0.602000													40	69					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48848975	48848975	+	Missense_Mutation	SNP	G	G	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr8:48848975G>T	ENST00000314191.2	-	12	1272	c.1216C>A	c.(1216-1218)Cgt>Agt	p.R406S	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Missense_Mutation_p.R406S	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	406					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TGATAAACACGGTCGTCACCA	0.443000								Non-homologous end-joining					4	161					0.150653	0.152671	1	1	0
ZNF174	7727	broad.mit.edu	37	16	3458476	3458476	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr16:3458476C>T	ENST00000268655.4	+	3	1366	c.781C>T	c.(781-783)Cgg>Tgg	p.R261W	ZNF174_ENST00000571936.1_Missense_Mutation_p.R261W|LA16c-306E5.2_ENST00000575785.1_RNA	NM_003450.2	NP_003441.1	Q15697	ZN174_HUMAN	zinc finger protein 174	261					negative regulation of transcription from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|cytoplasm|nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(2)|large_intestine(3)|lung(3)|prostate(2)|urinary_tract(2)	12						TCGGTTGTCACGGAGGCAGGT	0.522000													36	65					0	0	1	0	0
CAPNS1	826	broad.mit.edu	37	19	36631958	36631958	+	Silent	SNP	C	C	G			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr19:36631958C>G	ENST00000246533.3	+	2	643	c.45C>G	c.(43-45)ggC>ggG	p.G15G	CAPNS1_ENST00000590874.1_Silent_p.G15G|CAPNS1_ENST00000589146.1_Silent_p.G15G|CAPNS1_ENST00000588780.1_Silent_p.G15G|CAPNS1_ENST00000588815.1_Silent_p.G15G|CAPNS1_ENST00000587718.1_Silent_p.G15G	NM_001003962.1|NM_001749.2	NP_001003962.1|NP_001740.1	P04632	CPNS1_HUMAN	calpain, small subunit 1	15	Gly-rich (hydrophobic).|Poly-Gly.				positive regulation of cell proliferation	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			cervix(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	5	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			gcggcggcggcgggggaggcg	0.736000													3	33					0	0	1	0	0
S100A7L2	645922	broad.mit.edu	37	1	153410684	153410684	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr1:153410684G>A	ENST00000368725.2	-	2	154	c.155C>T	c.(154-156)cCc>cTc	p.P52L		NM_001045479.1	NP_001038944.2			S100 calcium binding protein A7-like 2											NS(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	8	all_lung(78;2.4e-33)|Lung NSC(65;8.13e-32)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			GAGGAAGTTGGGGAAGTTCTC	0.512000													23	59					0	0	1	0	0
DAPK1	1612	broad.mit.edu	37	9	90313685	90313685	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr9:90313685C>T	ENST00000469640.2	+	23	3101	c.2726C>T	c.(2725-2727)tCg>tTg	p.S909L	DAPK1_ENST00000491893.1_Missense_Mutation_p.S843L|DAPK1_ENST00000408954.3_Missense_Mutation_p.S909L|DAPK1_ENST00000358077.5_Missense_Mutation_p.S909L|DAPK1_ENST00000472284.1_Missense_Mutation_p.S909L			P53355	DAPK1_HUMAN	death-associated protein kinase 1	909					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(27)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(3)|stomach(1)	72						AAAGACACATCGTTGCTGAAA	0.532000									Chronic Lymphocytic Leukemia, Familial Clustering of				20	12					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106814320	106814320	+	Silent	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr8:106814320G>A	ENST00000407775.2	+	8	2260	c.2010G>A	c.(2008-2010)gtG>gtA	p.V670V	RP11-152P17.2_ENST00000509144.2_RNA|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000522296.1_3'UTR|ZFPM2_ENST00000520492.1_Silent_p.V538V|RP11-152P17.2_ENST00000521622.1_RNA|ZFPM2_ENST00000378472.4_Silent_p.V401V|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000520433.1_RNA|ZFPM2_ENST00000517361.1_Silent_p.V538V|RP11-152P17.2_ENST00000520594.1_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	670					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			CTGTTGATGTGAAAAATCCCA	0.443000													40	21					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25230233	25230233	+	RNA	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr15:25230233G>A	ENST00000551631.2	+	0	887				SNHG14_ENST00000551361.1_RNA	NR_001293.1																						AAGACATTGGGAAAGACCTGG	0.413000													29	46					0	0	1	0	0
SIN3A	25942	broad.mit.edu	37	15	75722644	75722644	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr15:75722644C>T	ENST00000394947.3	-	2	387	c.73G>A	c.(73-75)Gag>Aag	p.E25K	SIN3A_ENST00000567289.1_Missense_Mutation_p.E25K|SIN3A_ENST00000394949.4_Missense_Mutation_p.E25K|SIN3A_ENST00000360439.4_Missense_Mutation_p.E25K	NM_001145358.1	NP_001138830.1	Q96ST3	SIN3A_HUMAN	SIN3 transcription regulator family member A	25					blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	63						GGAAAAGCCTCTGTGCTGCCA	0.577000													23	47					0	0	1	0	0
AK9	221264	broad.mit.edu	37	6	109818714	109818714	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr6:109818714G>A	ENST00000424296.2	-	38	5345	c.5269C>T	c.(5269-5271)Cgt>Tgt	p.R1757C	RP5-919F19.5_ENST00000423747.1_RNA	NM_001145128.2	NP_001138600.2			adenylate kinase 9									p.R156C(1)|p.R1757C(1)									ATATATATACGATTATGATAT	0.299000													13	12					0	0	1	0	0
CHD7	55636	broad.mit.edu	37	8	61707586	61707586	+	Missense_Mutation	SNP	A	A	G			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr8:61707586A>G	ENST00000423902.2	+	4	2617	c.2138A>G	c.(2137-2139)aAg>aGg	p.K713R	CHD7_ENST00000524602.1_Intron|CHD7_ENST00000525508.1_Missense_Mutation_p.K713R	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	713	Lys-rich.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity	p.K713T(2)|p.556_871dup(1)		NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			TTGAAGAAAAAGGTCAACAAG	0.408000													3	111					0	0	1	0	0
ABCG1	9619	broad.mit.edu	37	21	43708014	43708014	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr21:43708014C>T	ENST00000398437.1	+	10	1575	c.1427C>T	c.(1426-1428)tCc>tTc	p.S476F	ABCG1_ENST00000361802.2_Missense_Mutation_p.S330F|ABCG1_ENST00000343687.3_Missense_Mutation_p.S341F|ABCG1_ENST00000462050.1_3'UTR|ABCG1_ENST00000347800.2_Missense_Mutation_p.S327F|ABCG1_ENST00000398457.2_Missense_Mutation_p.S332F|ABCG1_ENST00000340588.4_Missense_Mutation_p.S438F|ABCG1_ENST00000398449.3_Missense_Mutation_p.S330F			P45844	ABCG1_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 1	330	ABC transmembrane type-2.				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|ovary(3)|prostate(2)|stomach(1)	29					Adenosine triphosphate(DB00171)	GAGGTTGCATCCGGCGAGTAC	0.602000													14	427					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140183103	140183103	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr5:140183103C>T	ENST00000522353.2	+	1	2321	c.2321C>T	c.(2320-2322)cCt>cTt	p.P774L	PCDHA3_ENST00000532566.2_Missense_Mutation_p.P774L|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000520672.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTTTTAGCCCTAGCCTTCCT	0.527000													56	44					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56321459	56321459	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr19:56321459C>T	ENST00000443188.1	-	5	1227	c.517G>A	c.(517-519)Ggt>Agt	p.G173S	NLRP11_ENST00000360133.3_Missense_Mutation_p.G173S|NLRP11_ENST00000589824.2_Missense_Mutation_p.G173S|NLRP11_ENST00000589093.1_Missense_Mutation_p.G173S|NLRP11_ENST00000592953.1_Missense_Mutation_p.G74S	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	173	NACHT.						ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		CACATCTCACCCTTGATCCAC	0.453000													15	22					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21228367	21228367	+	Silent	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr2:21228367G>A	ENST00000233242.1	-	26	11500	c.11373C>T	c.(11371-11373)ttC>ttT	p.F3791F		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3791					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity	p.F3791F(1)		NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CAACTTCAGGGAATTTTACCT	0.403000													69	112					0	0	1	0	0
GINS3	64785	broad.mit.edu	37	16	58437029	58437029	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr16:58437029C>T	ENST00000318129.5	+	2	422	c.214C>T	c.(214-216)Ctg>Ttg	p.L72L	GINS3_ENST00000426538.2_Silent_p.L111L|GINS3_ENST00000328514.7_Intron	NM_022770.3	NP_073607.2	Q9BRX5	PSF3_HUMAN	GINS complex subunit 3 (Psf3 homolog)	72					DNA replication	nucleus				NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|skin(1)	7						ACCCTTGTGGCTGGCAAAAGG	0.448000													33	49					0	0	1	0	0
UBXN2A	165324	broad.mit.edu	37	2	24194250	24194250	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr2:24194250C>T	ENST00000309033.4	+	3	390	c.146C>T	c.(145-147)tCc>tTc	p.S49F	UBXN2A_ENST00000446425.2_3'UTR|UBXN2A_ENST00000535786.1_Missense_Mutation_p.S49F|UBXN2A_ENST00000404924.1_Missense_Mutation_p.S49F	NM_181713.3	NP_859064.2	P68543	UBX2A_HUMAN	UBX domain protein 2A	49										endometrium(1)|large_intestine(3)|liver(1)|lung(6)	11						AAGGTTAGTTCCAAATGTGTG	0.348000													44	73					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713845	142713845	+	RNA	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr1:142713845C>T	ENST00000369381.2	-	0	760																											CAATTTTCATCCATCAGATCT	0.284000													9	28					0	0	1	0	0
ATP2C1	27032	broad.mit.edu	37	3	130659495	130659495	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr3:130659495C>T	ENST00000510168.1	+	7	932	c.382C>T	c.(382-384)Ctt>Ttt	p.L128F	ATP2C1_ENST00000504381.1_Missense_Mutation_p.L73F|ATP2C1_ENST00000508532.1_Missense_Mutation_p.L128F|ATP2C1_ENST00000504948.1_Missense_Mutation_p.L112F|ATP2C1_ENST00000505330.1_Missense_Mutation_p.L112F|ATP2C1_ENST00000507488.2_Missense_Mutation_p.L112F|ATP2C1_ENST00000513801.1_Missense_Mutation_p.L112F|ATP2C1_ENST00000422190.2_Missense_Mutation_p.L128F|ATP2C1_ENST00000428331.2_Missense_Mutation_p.L128F|ATP2C1_ENST00000393221.4_Missense_Mutation_p.L162F|ATP2C1_ENST00000359644.3_Missense_Mutation_p.L128F|ATP2C1_ENST00000533801.2_Missense_Mutation_p.L123F|ATP2C1_ENST00000328560.8_Missense_Mutation_p.L128F			P98194	AT2C1_HUMAN	ATPase, Ca++ transporting, type 2C, member 1	128					actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|prostate(2)|skin(2)|urinary_tract(1)	39					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	AGAAAAATCTCTTGAAGAATT	0.303000									Hailey-Hailey disease				9	23					0	0	1	0	0
C1QB	713	broad.mit.edu	37	1	22987842	22987842	+	Missense_Mutation	SNP	T	T	C			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr1:22987842T>C	ENST00000509305.1	+	3	1065	c.719T>C	c.(718-720)tTt>tCt	p.F240S	C1QB_ENST00000314933.6_Missense_Mutation_p.F242S			P02746	C1QB_HUMAN	complement component 1, q subcomponent, B chain	242	C1q.				complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				breast(1)|endometrium(2)|large_intestine(1)|lung(9)|prostate(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.06e-27)|Colorectal(126;1.58e-07)|GBM - Glioblastoma multiforme(114;6.72e-06)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000551)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	AACAGCATCTTTTCCGGGTTC	0.607000													75	88					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17109501	17109501	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr3:17109501G>A	ENST00000418129.2	+	5	3235	c.2770G>A	c.(2770-2772)Gaa>Aaa	p.E924K	PLCL2_ENST00000396755.2_Missense_Mutation_p.E924K|PLCL2_ENST00000432376.1_Missense_Mutation_p.E924K	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	1050					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						AGGTTTGAAGGAAAGAAAACT	0.383000													27	62					0	0	1	0	0
GAK	2580	broad.mit.edu	37	4	860873	860873	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr4:860873G>A	ENST00000314167.4	-	21	2853	c.2743C>T	c.(2743-2745)Ctt>Ttt	p.L915F	GAK_ENST00000511163.1_Missense_Mutation_p.L836F|GAK_ENST00000509566.1_5'UTR	NM_005255.2	NP_005246.2	O14976	GAK_HUMAN	cyclin G associated kinase	915					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(16)|skin(7)|urinary_tract(2)	39				Colorectal(103;0.219)		GGGGGCCCAAGGAGGCAGCTG	0.736000													14	21					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113168926	113168926	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr9:113168926G>A	ENST00000401783.2	-	38	9290	c.8954C>T	c.(8953-8955)tCa>tTa	p.S2985L	SVEP1_ENST00000297826.5_Missense_Mutation_p.S911L|SVEP1_ENST00000374469.1_Missense_Mutation_p.S2962L	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2985	Sushi 26.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CCTTCTTGATGAATTTCCATG	0.463000													23	8					0	0	1	0	0
FAP	2191	broad.mit.edu	37	2	163076404	163076404	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr2:163076404G>A	ENST00000188790.4	-	7	652	c.445C>T	c.(445-447)Cca>Tca	p.P149S	FAP_ENST00000443424.1_Missense_Mutation_p.P124S	NM_004460.2	NP_004451.2	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha	149					endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(34)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)	63						TACTGAATTGGACGAGGAAGC	0.313000													25	27					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26771641	26771641	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr22:26771641C>T	ENST00000529632.2	+	14	3091	c.2895C>T	c.(2893-2895)taC>taT	p.Y965Y	SEZ6L_ENST00000402979.1_Silent_p.Y748Y|SEZ6L_ENST00000411842.2_Intron|SEZ6L_ENST00000404234.3_Silent_p.Y975Y|SEZ6L_ENST00000360929.3_Silent_p.Y901Y|SEZ6L_ENST00000494013.1_3'UTR|SEZ6L_ENST00000343706.4_Silent_p.Y900Y|SEZ6L_ENST00000248933.6_Silent_p.Y976Y|SEZ6L_ENST00000403121.1_Silent_p.Y672Y	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	976						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						GAGGAGCCTACATTTACATCA	0.582000													16	5					0	0	1	0	0
EPHB1	2047	broad.mit.edu	37	3	134911606	134911606	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr3:134911606C>T	ENST00000398015.3	+	11	2441	c.2071C>T	c.(2071-2073)Cgg>Tgg	p.R691W	EPHB1_ENST00000493838.1_Missense_Mutation_p.R252W	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	691	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						CACCAAGAGTCGGCCTGTCAT	0.527000													38	44					0	0	1	0	0
NRP2	8828	broad.mit.edu	37	2	206614461	206614461	+	Missense_Mutation	SNP	C	C	T	rs140796876	byFrequency	TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr2:206614461C>T	ENST00000360409.3	+	11	2590	c.1799C>T	c.(1798-1800)aCg>aTg	p.T600M	NRP2_ENST00000412873.2_Missense_Mutation_p.T600M|NRP2_ENST00000540178.1_Missense_Mutation_p.T600M|NRP2_ENST00000357785.5_Missense_Mutation_p.T600M|NRP2_ENST00000272849.3_Missense_Mutation_p.T600M|NRP2_ENST00000540841.1_Missense_Mutation_p.T600M|NRP2_ENST00000357118.4_Missense_Mutation_p.T600M	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718.1|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	600					angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						TCCAAGCCCACGGTAGAGACG	0.547000													3	72					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123554186	123554186	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chrX:123554186C>T	ENST00000422452.2	-	25	5020	c.4957G>A	c.(4957-4959)Gaa>Aaa	p.E1653K	TENM1_ENST00000371130.3_Missense_Mutation_p.E1646K|STAG2_ENST00000469481.1_Intron	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		CATCCATTTTCGTTACTTTTG	0.398000													49	91					0	0	1	0	0
BCRP7	100133163	broad.mit.edu	37	22	18844888	18844888	+	RNA	SNP	A	A	G			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr22:18844888A>G	ENST00000412938.1	+	0	3138																											GCTCACGGAAATACAGCTTCA	0.587000													3	62					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76023861	76023861	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr6:76023861C>T	ENST00000393004.2	-	5	1908	c.1687G>A	c.(1687-1689)Gaa>Aaa	p.E563K	FILIP1_ENST00000370020.1_Missense_Mutation_p.E464K|FILIP1_ENST00000498523.1_5'UTR|FILIP1_ENST00000237172.7_Missense_Mutation_p.E563K			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	563										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						TATACTTTTTCCTCCATTTCA	0.299000													8	8					0	0	1	0	0
BCL6B	255877	broad.mit.edu	37	17	6929856	6929856	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr17:6929856G>A	ENST00000293805.5	+	6	1062	c.970G>A	c.(970-972)Gaa>Aaa	p.E324K		NM_181844.3	NP_862827.1	Q8N143	BCL6B_HUMAN	B-cell CLL/lymphoma 6, member B	324						nucleus	zinc ion binding			skin(1)	1						TCCTGGGGACGAAGACAAACC	0.562000													73	102					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32029272	32029272	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr6:32029272G>A	ENST00000375244.3	-	21	7595	c.7394C>T	c.(7393-7395)aCc>aTc	p.T2465I	TNXB_ENST00000375247.2_Missense_Mutation_p.T2465I			P22105	TENX_HUMAN	tenascin XB	2525					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GCCCCCCACGGTGACCTCGCT	0.697000													56	72					0	0	1	0	0
OR5AP2	338675	broad.mit.edu	37	11	56409572	56409572	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr11:56409572C>T	ENST00000544374.1	-	1	375	c.347G>A	c.(346-348)gGg>gAg	p.G116E	OR5AP2_ENST00000302981.1_Missense_Mutation_p.G115E			Q8NGF4	O5AP2_HUMAN	olfactory receptor, family 5, subfamily AP, member 2	115					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	29						GCACTCAGTCCCCAGGAAGGA	0.512000													8	45					0	0	1	0	0
HLA-A	3105	broad.mit.edu	37	6	29910607	29910607	+	Silent	SNP	G	G	C	rs72555397		TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr6:29910607G>C	ENST00000396634.1	+	4	488	c.147G>C	c.(145-147)gtG>gtC	p.V49V	HLA-A_ENST00000376809.5_Silent_p.V49V|HLA-A_ENST00000376806.5_Silent_p.V49V|HLA-A_ENST00000376802.2_Silent_p.V49V			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	49	Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity	p.V49V(2)		central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						TCATCGCCGTGGGCTACGTGG	0.692000									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			4	61					0	0	1	0	0
HNRNPUL1	11100	broad.mit.edu	37	19	41807533	41807533	+	Missense_Mutation	SNP	C	C	G			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr19:41807533C>G	ENST00000392006.3	+	11	1784	c.1611C>G	c.(1609-1611)gaC>gaG	p.D537E	HNRNPUL1_ENST00000378215.4_Missense_Mutation_p.D423E|HNRNPUL1_ENST00000263367.3_Missense_Mutation_p.D448E|HNRNPUL1_ENST00000352456.3_Missense_Mutation_p.D437E|HNRNPUL1_ENST00000595018.1_Missense_Mutation_p.D437E|HNRNPUL1_ENST00000593587.1_Missense_Mutation_p.D437E|HNRNPUL1_ENST00000602130.1_Missense_Mutation_p.D537E	NM_007040.3	NP_008971.2	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	537	Necessary for interaction with BRD7 and transcriptional activation.|Necessary for interaction with TP53.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	29						CTGACGAGGACCTAAAAGACC	0.463000													34	60					0	0	1	0	0
TRGC1	6966	broad.mit.edu	37	7	38301806	38301806	+	RNA	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr7:38301806C>T	ENST00000443402.2	-	0	343					NM_001003799.1|NM_001003806.1	NP_001003799.1|NP_001003806.1																					CTTTGGGATCCATTGTGATGA	0.358000													70	98					0	0	1	0	0
STK11IP	114790	broad.mit.edu	37	2	220476375	220476375	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr2:220476375C>T	ENST00000456909.1	+	18	2244	c.2154C>T	c.(2152-2154)ctC>ctT	p.L718L	STK11IP_ENST00000295641.10_Silent_p.L729L			Q8N1F8	S11IP_HUMAN	serine/threonine kinase 11 interacting protein	729					protein localization	cytoplasm	protein kinase binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	23		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGGTTCTCCTCGCTGTGTCTC	0.622000													71	133					0	0	1	0	0
XKR4	114786	broad.mit.edu	37	8	56436411	56436411	+	Missense_Mutation	SNP	T	T	G			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr8:56436411T>G	ENST00000327381.5	+	3	1678	c.1578T>G	c.(1576-1578)tgT>tgG	p.C526W		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	526						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			CACCAAGTTGTGCTTGTGAGG	0.537000													34	152					0	0	1	0	0
DRD2	1813	broad.mit.edu	37	11	113286216	113286216	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr11:113286216C>T	ENST00000362072.3	-	5	994	c.650G>A	c.(649-651)cGc>cAc	p.R217H	DRD2_ENST00000538967.1_Missense_Mutation_p.R217H|DRD2_ENST00000535984.1_5'UTR|DRD2_ENST00000355319.2_Missense_Mutation_p.R217H|DRD2_ENST00000346454.3_Missense_Mutation_p.R217H|DRD2_ENST00000544518.1_Missense_Mutation_p.R216H|DRD2_ENST00000542968.1_Missense_Mutation_p.R217H	NM_000795.3	NP_000786.1	P14416	DRD2_HUMAN	dopamine receptor D2	217	Interaction with PPP1R9B (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(18)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	39		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	GCGGCGTCTGCGGAGGACAAT	0.572000													52	101					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90402494	90402494	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr6:90402494G>A	ENST00000369393.3	-	63	10370	c.10255C>T	c.(10255-10257)Cac>Tac	p.H3419Y	MDN1_ENST00000428876.1_Missense_Mutation_p.H3419Y			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	3419					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AGTGAGGTGTGGAGCTCAGAG	0.587000													33	25					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60897344	60897344	+	Silent	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr20:60897344G>A	ENST00000252999.3	-	47	6393	c.6327C>T	c.(6325-6327)ctC>ctT	p.L2109L		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	2109	Laminin EGF-like 21.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCTGCTCAGGGAGCCCCCAGT	0.697000													6	12					0	0	1	0	0
A2ML1	144568	broad.mit.edu	37	12	8995765	8995765	+	Silent	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr12:8995765G>A	ENST00000299698.7	+	12	1464	c.1284G>A	c.(1282-1284)ccG>ccA	p.P428P		NM_144670.4	NP_653271.2	B3KVV6	B3KVV6_HUMAN	alpha-2-macroglobulin-like 1	272						extracellular space	endopeptidase inhibitor activity			NS(2)|breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(2)|lung(36)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	80						TATATAATCCGGAACAAGTGC	0.488000													44	83					0	0	1	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20870068	20870068	+	Missense_Mutation	SNP	T	T	G			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr12:20870068T>G	ENST00000381552.1	+	7	1047	c.679T>G	c.(679-681)Tgt>Ggt	p.C227G	SLCO1C1_ENST00000540354.1_Missense_Mutation_p.C178G|SLCO1C1_ENST00000545102.1_Missense_Mutation_p.C109G|SLCO1C1_ENST00000266509.2_Missense_Mutation_p.C227G|SLCO1C1_ENST00000545604.1_Missense_Mutation_p.C227G			Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1	227					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					TGGTGCAGGGTGTGTGCAGAC	0.343000													12	32					0	0	1	0	0
MMP26	56547	broad.mit.edu	37	11	5013332	5013332	+	Missense_Mutation	SNP	T	T	G			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr11:5013332T>G	ENST00000380390.1	+	6	950	c.734T>G	c.(733-735)aTc>aGc	p.I245S	MMP26_ENST00000300762.1_Missense_Mutation_p.I245S			Q9NRE1	MMP26_HUMAN	matrix metallopeptidase 26	245					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(11)|pancreas(1)|skin(3)|stomach(1)	22		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		GCCGATGATATCCAAAGGATC	0.453000													13	38					0	0	1	0	0
NRROS	375387	broad.mit.edu	37	3	196387641	196387641	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr3:196387641G>A	ENST00000328557.4	+	3	1330	c.1127G>A	c.(1126-1128)gGa>gAa	p.G376E		NM_198565.1	NP_940967.1			negative regulator of reactive oxygen species																		GAGCCCCCCGGAGCGCTCACC	0.642000													37	88					0	0	1	0	0
ABCA17P	650655	broad.mit.edu	37	16	2474681	2474681	+	RNA	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr16:2474681G>A	ENST00000469908.1	+	0	2850					NR_003574.1																						GTTCAGCAGTGGCTACTCCCT	0.642000													12	14					0	0	1	0	0
PROM1	8842	broad.mit.edu	37	4	15989294	15989294	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr4:15989294C>T	ENST00000505450.1	-	19	2707	c.2095G>A	c.(2095-2097)Gga>Aga	p.G699R	PROM1_ENST00000539194.1_Missense_Mutation_p.G708R|PROM1_ENST00000447510.2_Missense_Mutation_p.G708R|PROM1_ENST00000510224.1_Missense_Mutation_p.G708R|PROM1_ENST00000543373.1_Missense_Mutation_p.G699R|PROM1_ENST00000540805.1_Missense_Mutation_p.G708R|PROM1_ENST00000508167.1_Missense_Mutation_p.G699R	NM_001145848.1	NP_001139320.1	O43490	PROM1_HUMAN	prominin 1	708					camera-type eye photoreceptor cell differentiation|photoreceptor cell maintenance|retina layer formation	apical plasma membrane|cell surface|integral to plasma membrane|microvillus membrane|photoreceptor outer segment membrane|plasma membrane	beta-actinin binding|cadherin binding			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|liver(1)|lung(11)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(2)	35						ACCAACAATCCATTCCCTGTG	0.358000													57	86					0	0	1	0	0
FUNDC2P2	388965	broad.mit.edu	37	2	84518287	84518287	+	RNA	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr2:84518287G>A	ENST00000331369.5	+	0	481																											AGAGCACTCAGATACCTAACC	0.468000													28	64					0	0	1	0	0
CKMT2	1160	broad.mit.edu	37	5	80547077	80547077	+	Silent	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr5:80547077G>A	ENST00000424301.2	+	3	364	c.126G>A	c.(124-126)cgG>cgA	p.R42R	CKMT2_ENST00000437669.1_Silent_p.R42R|CKMT2_ENST00000254035.4_Silent_p.R42R|CTC-281B15.1_ENST00000501927.2_RNA|CTC-281B15.1_ENST00000505295.1_RNA|CTC-281B15.1_ENST00000500148.2_RNA|CTC-281B15.1_ENST00000512287.1_RNA|CKMT2_ENST00000505704.1_3'UTR|CTC-281B15.1_ENST00000502041.2_RNA|CTC-281B15.1_ENST00000511495.1_RNA|CTC-281B15.1_ENST00000503483.2_RNA	NM_001825.2	NP_001816.2	P17540	KCRS_HUMAN	creatine kinase, mitochondrial 2 (sarcomeric)	42	Cardiolipin-binding (By similarity).				creatine metabolic process|muscle contraction	mitochondrial inner membrane	ATP binding|creatine kinase activity			breast(2)|cervix(1)|endometrium(2)|large_intestine(7)|lung(4)|urinary_tract(1)	17		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0336)		OV - Ovarian serous cystadenocarcinoma(54;2.29e-44)|Epithelial(54;1.05e-38)|all cancers(79;4.15e-34)	Creatine(DB00148)	CCGAGGTCCGGGAGCAGCCTA	0.552000													113	57					0	0	1	0	0
OR6C70	390327	broad.mit.edu	37	12	55863874	55863874	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr12:55863874C>T	ENST00000327335.4	-	1	48	c.49G>A	c.(49-51)Gat>Aat	p.D17N	RP11-110A12.2_ENST00000555138.1_RNA|RP11-110A12.2_ENST00000555146.1_RNA|RP11-110A12.2_ENST00000556750.1_RNA|RP11-110A12.2_ENST00000554049.1_RNA	NM_001005499.1	NP_001005499.1	A6NIJ9	O6C70_HUMAN	olfactory receptor, family 6, subfamily C, member 70	17					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	18						TGAGAATTATCCGTCAGTCCC	0.353000													21	28					0	0	1	0	0
CCDC144CP	348254	broad.mit.edu	37	17	20224844	20224844	+	RNA	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr17:20224844C>T	ENST00000580225.1	+	0	105				CCDC144CP_ENST00000340196.4_RNA																							TTAGACCAGCCCCAGCACGAT	0.652000													6	285					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6971869	6971869	+	Missense_Mutation	SNP	C	C	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr18:6971869C>A	ENST00000389658.3	-	48	6979	c.6886G>T	c.(6886-6888)Ggg>Tgg	p.G2296W		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	2296	Laminin G-like 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCGAAGCACCCACGGCACTTG	0.433000													37	36					6.4771e-29	6.87057e-29	1	1	0
IGF2BP3	10643	broad.mit.edu	37	7	23352000	23352000	+	Missense_Mutation	SNP	G	G	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr7:23352000G>T	ENST00000258729.3	-	15	2077	c.1721C>A	c.(1720-1722)cCt>cAt	p.P574H		NM_006547.2	NP_006538.2	O00425	IF2B3_HUMAN	insulin-like growth factor 2 mRNA binding protein 3	574					anatomical structure morphogenesis|negative regulation of translation|translation	cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(14)|ovary(2)|prostate(2)|skin(4)|stomach(1)	34						TCTTGACTGAGGTGGTCCACT	0.498000													42	86					1.51926e-22	1.60405e-22	1	1	0
RP11-166D19.1	0	broad.mit.edu	37	11	121970470	121970470	+	RNA	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr11:121970470G>A	ENST00000531381.1	-	0	732				MIR125B1_ENST00000385236.1_RNA																							GCAAAAGCACGACTCGCAGCT	0.413000													6	17					0	0	1	0	0
PDZRN3	23024	broad.mit.edu	37	3	73453542	73453542	+	Missense_Mutation	SNP	T	T	C			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr3:73453542T>C	ENST00000263666.4	-	4	1037	c.923A>G	c.(922-924)aAc>aGc	p.N308S	PDZRN3_ENST00000535920.1_Missense_Mutation_p.N30S|PDZRN3_ENST00000466780.1_5'UTR|PDZRN3_ENST00000462146.2_5'UTR|PDZRN3_ENST00000479530.1_Missense_Mutation_p.N25S	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	308	PDZ 1.						ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		GTCTCTGCCGTTGACCTGTGG	0.458000													24	44					0	0	1	0	0
MTERFD3	80298	broad.mit.edu	37	12	107371895	107371895	+	Missense_Mutation	SNP	C	C	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr12:107371895C>A	ENST00000552029.1	-	2	2666	c.598G>T	c.(598-600)Ggc>Tgc	p.G200C	C12orf23_ENST00000551237.1_Intron|MTERFD3_ENST00000240050.4_Missense_Mutation_p.G200C|MTERFD3_ENST00000392830.2_Missense_Mutation_p.G200C			Q49AM1	MTER3_HUMAN	MTERF domain containing 3	200					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	transcription regulatory region DNA binding			breast(1)|kidney(1)|large_intestine(2)|lung(3)	7						GCCTCAGAGCCACCTACATCT	0.358000													3	44					1	1	1	1	0
USHBP1	83878	broad.mit.edu	37	19	17370518	17370518	+	Silent	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr19:17370518G>A	ENST00000252597.3	-	6	965	c.792C>T	c.(790-792)ccC>ccT	p.P264P	USHBP1_ENST00000431146.2_Silent_p.P200P	NM_031941.3	NP_114147.2	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	264							PDZ domain binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(10)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44						GCCGAAGCAGGGGGTGAGCCA	0.562000													57	40					0	0	1	0	0
TRAV8-1	28685	broad.mit.edu	37	14	22265815	22265815	+	RNA	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr14:22265815C>T	ENST00000390430.2	+	0	230																											GTAATTCTCTCTGAAGCAGCC	0.458000													75	45					0	0	1	0	0
LEFTY1	10637	broad.mit.edu	37	1	226075168	226075168	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr1:226075168G>A	ENST00000272134.5	-	3	747	c.668C>T	c.(667-669)tCg>tTg	p.S223L	RP4-559A3.7_ENST00000432920.2_Silent_p.L331L	NM_020997.3	NP_066277.1	O75610	LFTY1_HUMAN	left-right determination factor 1	223					cell growth|multicellular organismal development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity|transforming growth factor beta receptor binding			cervix(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	10	Breast(184;0.197)					CGCCCCCTGCGAGGCAAAGCG	0.701000													22	39					0	0	1	0	0
BTRC	8945	broad.mit.edu	37	10	103310477	103310477	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr10:103310477C>T	ENST00000370187.3	+	14	1796	c.1678C>T	c.(1678-1680)Cga>Tga	p.R560*	BTRC_ENST00000408038.2_Nonsense_Mutation_p.R524*|BTRC_ENST00000393441.4_Nonsense_Mutation_p.R519*|BTRC_ENST00000493877.1_3'UTR	NM_033637.3	NP_378663.1	Q9Y297	FBW1A_HUMAN	beta-transducin repeat containing E3 ubiquitin protein ligase	560					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|positive regulation of proteolysis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|viral reproduction|Wnt receptor signaling pathway	cytosol|nucleus|SCF ubiquitin ligase complex		p.R560*(1)		endometrium(4)|kidney(2)|large_intestine(6)|lung(11)|ovary(2)|stomach(1)|urinary_tract(1)	27		Colorectal(252;0.234)		Epithelial(162;1.05e-08)|all cancers(201;6.59e-07)		AAGAGTTTTTCGACTACAGTT	0.408000													33	25					0	0	1	0	0
NUP210L	91181	broad.mit.edu	37	1	154027298	154027298	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr1:154027298G>A	ENST00000368559.3	-	24	3322	c.3251C>T	c.(3250-3252)cCa>cTa	p.P1084L	NUP210L_ENST00000271854.3_Missense_Mutation_p.P1084L|NUP210L_ENST00000368553.1_Missense_Mutation_p.P17L	NM_207308.2	NP_997191.2	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like	1084						integral to membrane				NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|lung(34)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|urinary_tract(2)	80	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			AAGTCTGAATGGAGGAAACAC	0.323000													19	28					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28539833	28539833	+	Missense_Mutation	SNP	T	T	C			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr6:28539833T>C	ENST00000452236.2	-	4	4450	c.3833A>G	c.(3832-3834)gAg>gGg	p.E1278G		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	1278					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						gaatccggtctcacagaggta	0.358000													25	41					0	0	1	0	0
AGRN	375790	broad.mit.edu	37	1	983033	983033	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr1:983033C>T	ENST00000379370.2	+	21	3647	c.3597C>T	c.(3595-3597)tcC>tcT	p.S1199S		NM_198576.3	NP_940978.2	O00468	AGRIN_HUMAN	agrin	1199	SEA.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	42	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		CCGGCAAATCCGTCCGCGCCA	0.617000													52	70					0	0	1	0	0
WDR44	54521	broad.mit.edu	37	X	117527200	117527200	+	Silent	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chrX:117527200G>A	ENST00000254029.3	+	4	1187	c.792G>A	c.(790-792)ttG>ttA	p.L264L	WDR44_ENST00000371825.3_Silent_p.L264L|WDR44_ENST00000371822.5_Silent_p.L239L	NM_019045.4	NP_061918.3	Q5JSH3	WDR44_HUMAN	WD repeat domain 44	264						cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				breast(4)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	33						AAAGCGAATTGGAATTTGAGA	0.493000													75	142					0	0	1	0	0
DSN1	79980	broad.mit.edu	37	20	35399564	35399564	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr20:35399564G>A	ENST00000426836.1	-	3	439	c.67C>T	c.(67-69)Cat>Tat	p.H23Y	DSN1_ENST00000373745.3_Missense_Mutation_p.H23Y|DSN1_ENST00000448110.1_Missense_Mutation_p.H7Y|DSN1_ENST00000373740.3_Intron|DSN1_ENST00000473615.1_5'UTR|DSN1_ENST00000373750.4_Missense_Mutation_p.H23Y|DSN1_ENST00000373734.4_Intron	NM_001145316.1	NP_001138788.1	Q9H410	DSN1_HUMAN	DSN1, MIS12 kinetochore complex component	23					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	16		Myeloproliferative disorder(115;0.00874)				TCCAATTGATGATCATGAGTC	0.393000													75	101					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140482253	140482253	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr5:140482253C>T	ENST00000231130.2	+	1	2020	c.2020C>T	c.(2020-2022)Ccg>Tcg	p.P674S		NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		674					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTGCCTCTCCCGGAGGCGGC	0.672000													106	47					0	0	1	0	0
CCDC11	220136	broad.mit.edu	37	18	47788478	47788478	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr18:47788478G>A	ENST00000398545.4	-	2	298	c.181C>T	c.(181-183)Cgc>Tgc	p.R61C		NM_145020.3	NP_659457.2	Q96M91	CCD11_HUMAN	coiled-coil domain containing 11	61										endometrium(1)|kidney(4)|large_intestine(6)|lung(6)|ovary(1)|pancreas(1)|skin(1)	20				STAD - Stomach adenocarcinoma(97;2.66e-05)|Colorectal(21;7.57e-05)|Lung(128;0.00932)|READ - Rectum adenocarcinoma(32;0.164)		GCTTTCAAGCGATCCCGCTCA	0.468000													51	100					0	0	1	0	0
GABRE	2564	broad.mit.edu	37	X	151128345	151128345	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chrX:151128345C>T	ENST00000370325.1	-	6	803	c.750G>A	c.(748-750)gtG>gtA	p.V250V	GABRE_ENST00000370328.3_Silent_p.V250V|GABRE_ENST00000393914.3_Silent_p.V57V			P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor, epsilon	250					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|skin(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TTTTGTTGCTCACTCCTGTAA	0.453000													27	57					0	0	1	0	0
MAGEB16	139604	broad.mit.edu	37	X	35820703	35820703	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chrX:35820703G>A	ENST00000399989.1	+	2	669	c.390G>A	c.(388-390)atG>atA	p.M130I	MAGEB16_ENST00000399988.1_Missense_Mutation_p.M130I|MAGEB16_ENST00000399992.1_Missense_Mutation_p.M162I|MAGEB16_ENST00000399985.1_Missense_Mutation_p.M130I|MAGEB16_ENST00000399987.1_Missense_Mutation_p.M130I	NM_001099921.1	NP_001093391.1	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	130	MAGE.									breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(16)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31						AGTGTCAGATGAAAAAGCCAA	0.458000													24	36					0	0	1	0	0
CRABP2	1382	broad.mit.edu	37	1	156670351	156670351	+	Missense_Mutation	SNP	C	C	T	rs146571038	byFrequency	TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr1:156670351C>T	ENST00000368222.3	-	3	503	c.349G>A	c.(349-351)Gat>Aat	p.D117N	CRABP2_ENST00000368221.1_Missense_Mutation_p.D117N	NM_001199723.1|NM_001878.3	NP_001186652.1|NP_001869.1	P29373	RABP2_HUMAN	cellular retinoic acid binding protein 2	117					epidermis development|regulation of transcription, DNA-dependent|signal transduction	cytoplasm|nucleus	retinal binding|retinol binding|transporter activity			endometrium(2)|lung(3)|upper_aerodigestive_tract(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)				Alitretinoin(DB00523)	AGTTCCCCATCGTTGGTCAGT	0.547000													34	59					0	0	1	0	0
C9orf96	169436	broad.mit.edu	37	9	136259526	136259526	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr9:136259526C>T	ENST00000371957.3	+	8	799	c.692C>T	c.(691-693)tCc>tTc	p.S231F	C9orf96_ENST00000371955.1_5'UTR	NM_153710.3	NP_714921.3	Q8NE28	SGK71_HUMAN	chromosome 9 open reading frame 96	231	Protein kinase.						ATP binding|protein kinase activity			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|stomach(2)	25				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		ACCAGCTGCTCCTTCATGGAT	0.617000													38	35					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73479985	73479985	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr8:73479985C>T	ENST00000523207.1	+	2	604	c.16C>T	c.(16-18)Ccc>Tcc	p.P6S		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	6					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			AGAAAAGGCTCCCCCGGGCTT	0.502000													138	66					0	0	1	0	0
F11	2160	broad.mit.edu	37	4	187206838	187206838	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr4:187206838C>T	ENST00000264692.4	+	12	1528	c.1195C>T	c.(1195-1197)Caa>Taa	p.Q399*	F11_ENST00000403665.2_Nonsense_Mutation_p.Q451*			P03951	FA11_HUMAN	coagulation factor XI	451	Peptidase S1.		W -> R (in dbSNP:rs1800439).		blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	32		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	CATTTTAAATCAATCTGAAAT	0.353000													30	48					0	0	1	0	0
ILDR2	387597	broad.mit.edu	37	1	166927264	166927264	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr1:166927264G>A	ENST00000271417.3	-	2	176	c.121C>T	c.(121-123)Cgc>Tgc	p.R41C	ILDR2_ENST00000529387.1_Missense_Mutation_p.R41C|ILDR2_ENST00000529071.1_Missense_Mutation_p.R41C|ILDR2_ENST00000525740.1_Missense_Mutation_p.R41C|ILDR2_ENST00000469934.2_Missense_Mutation_p.R41C|ILDR2_ENST00000528703.1_Missense_Mutation_p.R41C|ILDR2_ENST00000526687.1_Missense_Mutation_p.R41C	NM_199351.2	NP_955383.1	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor 2	41	Ig-like V-type.					integral to membrane				NS(3)|breast(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	22						AAGTGGCAGCGAAGCACAGTG	0.542000													81	112					0	0	1	0	0
FAR1	84188	broad.mit.edu	37	11	13733493	13733493	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr11:13733493C>T	ENST00000354817.3	+	7	931	c.787C>T	c.(787-789)Cga>Tga	p.R263*	FAR1_ENST00000527202.1_3'UTR	NM_032228.5	NP_115604.1	Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	263					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	13						AGGAATTCTTCGAACAATACG	0.368000													16	26					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179588843	179588843	+	Missense_Mutation	SNP	C	C	T	rs148072021	by1000genomes	TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr2:179588843C>T	ENST00000589042.1	-	73	21367	c.21143G>A	c.(21142-21144)cGa>cAa	p.R7048Q	TTN_ENST00000591111.1_Missense_Mutation_p.R6731Q|TTN_ENST00000342175.6_Intron|RP11-171I2.1_ENST00000590024.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R5804Q|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6731	Ig-like 52.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R5804L(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCAGTCTTCGTGTGAAAGA	0.418000													6	19					0	0	1	0	0
MPRIP	23164	broad.mit.edu	37	17	17034973	17034973	+	Silent	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr17:17034973G>A	ENST00000395811.5	+	5	551	c.462G>A	c.(460-462)caG>caA	p.Q154Q	MPRIP_ENST00000395804.3_Silent_p.Q154Q|MPRIP_ENST00000341712.4_Silent_p.Q154Q|MPRIP_ENST00000444976.1_Silent_p.Q154Q	NM_015134.3|NM_201274.3	NP_055949.2|NP_958431.2	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase Rho interacting protein	154	Interaction with F-actin (By similarity).					cytoplasm|cytoskeleton	actin binding			biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	31						CCAACAAGCAGAATCAGAAGA	0.567000													30	45					0	0	1	0	0
NRG3	10718	broad.mit.edu	37	10	84744883	84744883	+	Missense_Mutation	SNP	G	G	A	rs117241349		TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr10:84744883G>A	ENST00000372142.2	+	11	1296	c.1022G>A	c.(1021-1023)cGa>cAa	p.R341Q	NRG3_ENST00000537893.1_Missense_Mutation_p.R188Q|NRG3_ENST00000556918.1_Missense_Mutation_p.R368Q|NRG3_ENST00000404547.1_Missense_Mutation_p.R562Q|NRG3_ENST00000404576.2_Missense_Mutation_p.R342Q|NRG3_ENST00000372141.2_Missense_Mutation_p.R538Q|NRG3_ENST00000545131.1_Missense_Mutation_p.R188Q	NM_001165973.1	NP_001159445.1	P56975	NRG3_HUMAN	neuregulin 3	562					regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity	p.R538Q(1)|p.R341Q(1)		breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(41)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	69				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		AAAACCCAACGAAATACATCA	0.408000													83	53					0	0	1	0	0
LRP4	4038	broad.mit.edu	37	11	46914607	46914607	+	Silent	SNP	G	G	A			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr11:46914607G>A	ENST00000378623.1	-	13	1856	c.1614C>T	c.(1612-1614)gcC>gcT	p.A538A		NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	538					endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		CATCCAGATTGGCCACCTCAA	0.572000													9	30					0	0	1	0	0
TMPRSS11F	389208	broad.mit.edu	37	4	68934443	68934443	+	Silent	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr4:68934443C>T	ENST00000356291.2	-	7	707	c.648G>A	c.(646-648)ggG>ggA	p.G216G	RP11-453E17.1_ENST00000500538.2_RNA|RP11-453E17.1_ENST00000511571.1_RNA|RP11-453E17.1_ENST00000499180.2_RNA	NM_207407.2	NP_997290.2	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	216	Peptidase S1.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(4)	39						ATGGCCATTCCCCTTCCATAG	0.522000													33	54					0	0	1	0	0
EBI3	10148	broad.mit.edu	37	19	4231212	4231212	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr19:4231212C>T	ENST00000221847.5	+	2	145	c.92C>T	c.(91-93)cCc>cTc	p.P31L		NM_005755.2	NP_005746.2	Q14213	IL27B_HUMAN	Epstein-Barr virus induced 3	31	Fibronectin type-III 1.				humoral immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of interferon-gamma biosynthetic process|T-helper 1 type immune response	extracellular space|plasma membrane	cytokine activity|cytokine receptor activity			large_intestine(1)|lung(2)|ovary(1)|urinary_tract(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0336)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGACACTGCCCCGGGTGCAA	0.637000													12	26					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240255569	240255571	+	In_Frame_Del	DEL	GGC	GGC	-	rs71929261		TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr1:240255569_240255571delGGC	ENST00000319653.9	+	1	390_392	c.160_162delGGC	c.(160-162)del	p.G59del		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	59					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding	p.G197delG(1)		NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GGGGGGAgggggcggcggcggcg	0.665													11	19	---	---	---	---					
MAP3K2	10746	broad.mit.edu	37	2	128100701	128100701	+	Splice_Site	DEL	C	C	-			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr2:128100701delC	ENST00000409947.1	-	2	287		c.e2+1		MAP3K2_ENST00000344908.5_Splice_Site			Q9Y2U5	M3K2_HUMAN	mitogen-activated protein kinase kinase kinase 2						activation of JUN kinase activity|cellular response to mechanical stimulus	nucleus	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein kinase binding			central_nervous_system(1)|large_intestine(1)|lung(3)|ovary(2)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0706)		TTTGAACTCACCCATTATGGC	0.294													2	4	---	---	---	---					
PCDH10	57575	broad.mit.edu	37	4	134073569	134073571	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr4:134073569_134073571delCTG	ENST00000264360.4	+	1	3100_3102	c.2274_2276delCTG	c.(2272-2277)ctc>ct	p.LC758del		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	758	Cys-rich.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		ATTGCTGCCTCTGCTGCTGCTGC	0.581													11	90	---	---	---	---					
MANEA	79694	broad.mit.edu	37	6	96034896	96034897	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr6:96034896_96034897delTG	ENST00000369293.1	+	2	715_716	c.581_582delTG	c.(580-582)cfs	p.L194fs	MANEA_ENST00000358812.4_Intron			Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	0	Catalytic (Probable).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			breast(2)|endometrium(3)|kidney(2)|liver(2)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		tgtttgtgtctgtatatatgca	0.282													3	6	---	---	---	---					
RP11-180I4.2	0	broad.mit.edu	37	9	98468148	98468149	+	RNA	INS	-	-	ACT			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr9:98468148_98468149insACT	ENST00000580326.1	+	0	189																											caatcaccatcaccaccaccac	0.569													2	4	---	---	---	---					
TPTE2P1	646405	broad.mit.edu	37	13	25527490	25527491	+	RNA	INS	-	-	AAAAAG			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr13:25527490_25527491insAAAAAG	ENST00000429698.1	-	0	282																											AGGAAGGTTCTAAAAAAAATTT	0.252													4	5	---	---	---	---					
GSE1	23199	broad.mit.edu	37	16	85682290	85682290	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr16:85682290delC	ENST00000253458.7	+	3	535	c.359delC	c.(358-360)acfs	p.T120fs	GSE1_ENST00000405402.2_Frame_Shift_Del_p.T16fs|GSE1_ENST00000393243.1_Frame_Shift_Del_p.T47fs	NM_014615.2	NP_055430.1			Gse1 coiled-coil protein									p.V123fs*2(1)									GTGCCCAGCACCCCCCCCGTG	0.687													8	204	---	---	---	---					
RP11-161I6.2	0	broad.mit.edu	37	18	2127314	2127315	+	RNA	INS	-	-	TT	rs35166795	by1000genomes	TCGA-BF-A3DJ-01A-11D-A20D-08	TCGA-BF-A3DJ-10A-02D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4e207fb-76b8-4330-baa4-7658431d42dd	517609a6-e93b-45ef-95c4-b8684db50350	g.chr18:2127314_2127315insTT	ENST00000579097.1	-	0	132																											tcatgtctctctgcccagttca	0.515													4	3	---	---	---	---					
