Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TENM1	10178	broad.mit.edu	37	X	124030042	124030042	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chrX:124030042G>A	ENST00000422452.2	-	2	329	c.266C>T	c.(265-267)aCa>aTa	p.T89I	TENM1_ENST00000371130.3_Missense_Mutation_p.T89I	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		GTGCATGTCTGTTTGGTAGCC	0.473000													80	51					0	0	0.870114	0	0
SH2D3C	10044	broad.mit.edu	37	9	130513556	130513556	+	Silent	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr9:130513556C>T	ENST00000314830.8	-	4	692	c.579G>A	c.(577-579)ctG>ctA	p.L193L	SH2D3C_ENST00000429553.1_5'UTR|SH2D3C_ENST00000420366.1_Silent_p.L35L|SH2D3C_ENST00000471939.1_5'UTR|SH2D3C_ENST00000373276.3_Silent_p.L125L|SH2D3C_ENST00000373277.4_Silent_p.L36L|SH2D3C_ENST00000373274.3_Silent_p.L33L	NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C	193					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						GCGATGAGTCCAGGATGTACT	0.517000													67	26					0	0	0.870114	0	0
FAM135B	51059	broad.mit.edu	37	8	139163542	139163542	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr8:139163542G>A	ENST00000395297.1	-	13	3346	c.3176C>T	c.(3175-3177)tCc>tTc	p.S1059F		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1059										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GGTCTGTTTGGAAGAGAATCC	0.522000										HNSCC(54;0.14)			28	23					0	0	0.740014	0	0
MROH7	374977	broad.mit.edu	37	1	55167796	55167796	+	Silent	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr1:55167796C>T	ENST00000414150.2	+	20	3597	c.3319C>T	c.(3319-3321)Ctg>Ttg	p.L1107L	MROH7_ENST00000421030.2_Silent_p.L1107L|MROH7_ENST00000409996.1_Silent_p.L675L|MROH7_ENST00000454855.2_Silent_p.L625L					maestro heat-like repeat family member 7																		CTGCATCAACCTGTATGGGAA	0.622000													15	22					0	0	0.557998	0	0
PCDHA7	56141	broad.mit.edu	37	5	140215804	140215804	+	Silent	SNP	A	A	G			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr5:140215804A>G	ENST00000525929.1	+	1	1836	c.1836A>G	c.(1834-1836)caA>caG	p.Q612Q	PCDHA7_ENST00000378125.3_Silent_p.Q612Q|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGAGTTGCAACCGGTGGCGG	0.647000													28	99					0	0	0.760397	0	0
EEF1D	1936	broad.mit.edu	37	8	144668986	144668986	+	Missense_Mutation	SNP	C	C	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr8:144668986C>A	ENST00000532741.1	-	2	1506	c.1278G>T	c.(1276-1278)aaG>aaT	p.K426N	EEF1D_ENST00000529272.1_Missense_Mutation_p.K10N|EEF1D_ENST00000423316.2_Missense_Mutation_p.K376N|EEF1D_ENST00000531621.1_Missense_Mutation_p.K10N|EEF1D_ENST00000532400.1_Missense_Mutation_p.K10N|EEF1D_ENST00000524624.1_Missense_Mutation_p.K10N|EEF1D_ENST00000528610.1_Missense_Mutation_p.K10N|EEF1D_ENST00000317198.6_Missense_Mutation_p.K10N|EEF1D_ENST00000526838.1_Missense_Mutation_p.K10N|EEF1D_ENST00000419152.2_Missense_Mutation_p.K10N|EEF1D_ENST00000442189.2_Missense_Mutation_p.K376N|EEF1D_ENST00000395119.3_Missense_Mutation_p.K10N			P29692	EF1D_HUMAN	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)	10					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|signal transducer activity|translation elongation factor activity			breast(2)|cervix(1)|endometrium(1)|kidney(4)|lung(2)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			CGAACCAGATCTTCTCATGTG	0.547000													5	152					0.0215528	0.0225475	0.217242	1	0
BAGE2	85319	broad.mit.edu	37	21	11058340	11058340	+	RNA	SNP	A	A	C	rs28617310	by1000genomes	TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr21:11058340A>C	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GGGGTAAAGGAGAGAAATCTC	0.363000													14	159					0	0	0.479597	0	0
RP1L1	94137	broad.mit.edu	37	8	10469525	10469525	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr8:10469525C>T	ENST00000382483.3	-	4	2306	c.2083G>A	c.(2083-2085)Gcc>Acc	p.A695T		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	695					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		TCCTGGCAGGCCCTTCGCCGC	0.617000													34	16					0	0	0.796494	0	0
CROCCP2	84809	broad.mit.edu	37	1	16946434	16946434	+	RNA	SNP	C	C	T	rs367060		TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr1:16946434C>T	ENST00000412962.1	-	0	1085																											CTCAGCCTTCCGCCGGGCCAG	0.672000													7	37					0	0	0.278610	0	0
SNHG12	85028	broad.mit.edu	37	1	28907523	28907523	+	RNA	SNP	A	A	G			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr1:28907523A>G	ENST00000488745.1	-	0	1013				SNHG12_ENST00000475441.1_RNA|SNHG12_ENST00000531126.1_RNA|SNHG12_ENST00000483436.1_RNA|SNHG12_ENST00000384342.1_RNA																							CTTTTTGACCACAGCAGCTAT	0.507000													41	71					0	0	0.870114	0	0
IL23R	149233	broad.mit.edu	37	1	67666516	67666516	+	Silent	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr1:67666516C>T	ENST00000347310.5	+	5	759	c.588C>T	c.(586-588)gtC>gtT	p.V196V	IL23R_ENST00000371002.1_Silent_p.V196V|C1orf141_ENST00000371007.2_Intron	NM_144701.2	NP_653302.2	Q5VWK5	IL23R_HUMAN	interleukin 23 receptor	196	Fibronectin type-III 1.				inflammatory response|negative regulation of interleukin-10 production|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|response to interferon-gamma|response to lipopolysaccharide	interleukin-23 receptor complex	receptor activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	21						TGGTTTGGGTCCAAGCAGCAA	0.373000													39	77					0	0	0.870114	0	0
COL7A1	1294	broad.mit.edu	37	3	48622192	48622192	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr3:48622192C>T	ENST00000328333.8	-	34	4129	c.4022G>A	c.(4021-4023)gGa>gAa	p.G1341E	COL7A1_ENST00000454817.1_Missense_Mutation_p.G1341E	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	1341	Interrupted collagenous region.|Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GCCTCGAGGTCCTCGCTCTCC	0.667000													14	50					0	0	0.520397	0	0
ZNF708	7562	broad.mit.edu	37	19	21476165	21476165	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr19:21476165C>T	ENST00000356929.3	-	4	1800	c.1603G>A	c.(1603-1605)Gaa>Aaa	p.E535K		NM_021269.2	NP_067092.2	P17019	ZN708_HUMAN	zinc finger protein 708	535					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|skin(2)|stomach(1)	32						CCACATTCTTCACATTTGTAG	0.358000													4	62					0	0	0.150653	0	0
UGT1A10	54575	broad.mit.edu	37	2	234545533	234545533	+	Missense_Mutation	SNP	C	C	T	rs145610800		TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr2:234545533C>T	ENST00000344644.5	+	1	434	c.365C>T	c.(364-366)tCg>tTg	p.S122L	UGT1A10_ENST00000373445.1_Missense_Mutation_p.S122L|UGT1A8_ENST00000373450.4_Intron	NM_019075.2	NP_061948.1														endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(2)|skin(3)	32		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		TTATTTTTTTCGCATTGCAGG	0.363000													17	119					0	0	0.608945	0	0
KIR3DL3	115653	broad.mit.edu	37	19	55239263	55239263	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr19:55239263C>T	ENST00000291860.1	+	4	560	c.542C>T	c.(541-543)tCc>tTc	p.S181F	CTB-61M7.1_ENST00000400864.3_RNA|KIR3DL1_ENST00000402254.2_Intron|KIR2DL4_ENST00000396284.2_Intron|KIR3DL1_ENST00000541392.1_Intron|KIR3DL1_ENST00000538269.1_Intron	NM_153443.3	NP_703144.2	Q8N743	KI3L3_HUMAN	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3	181	Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(3)|prostate(1)|skin(1)	21				GBM - Glioblastoma multiforme(193;0.0192)		GTCAACTATTCCATGGGTCCC	0.572000													69	56					0	0	0.870114	0	0
KYNU	8942	broad.mit.edu	37	2	143790836	143790836	+	Silent	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr2:143790836C>T	ENST00000264170.4	+	12	1245	c.987C>T	c.(985-987)ttC>ttT	p.F329F	KYNU_ENST00000409512.1_Silent_p.F329F	NM_003937.2	NP_003928.1	Q16719	KYNU_HUMAN	kynureninase	329					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			large_intestine(10)|liver(1)|lung(18)|prostate(3)|skin(4)	36				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	TCTGTGGATTCCGAATTTCAA	0.373000													139	131					0	0	0.870114	0	0
ZNF761	388561	broad.mit.edu	37	19	53959186	53959186	+	RNA	SNP	C	C	G			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr19:53959186C>G	ENST00000454407.1	+	0	1878							Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		ACAAAGCTTTCCGTTTCAAAT	0.423000													38	72					0	0	0.812448	0	0
ZNF761	388561	broad.mit.edu	37	19	53959187	53959187	+	RNA	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr19:53959187C>T	ENST00000454407.1	+	0	1879							Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		CAAAGCTTTCCGTTTCAAATC	0.423000													37	73					0	0	0.804634	0	0
ARHGEF28	64283	broad.mit.edu	37	5	73168939	73168939	+	Silent	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr5:73168939C>T	ENST00000545377.1	+	22	2858	c.2682C>T	c.(2680-2682)ttC>ttT	p.F894F	ARHGEF28_ENST00000513042.2_Silent_p.F894F|ARHGEF28_ENST00000426542.2_Silent_p.F894F|ARHGEF28_ENST00000437974.1_Silent_p.F894F|ARHGEF28_ENST00000296794.6_Silent_p.F894F|ARHGEF28_ENST00000287898.5_Silent_p.F894F|ARHGEF28_ENST00000296799.4_Silent_p.F581F	NM_001080479.2	NP_001073948.2			Rho guanine nucleotide exchange factor (GEF) 28																		ATAAAATTTTCCCCTGTTTAG	0.468000													10	16					0	0	0.411799	0	0
TSSC2	650368	broad.mit.edu	37	11	3427765	3427765	+	RNA	SNP	G	G	C			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr11:3427765G>C	ENST00000529482.1	+	0	882																											CACACGTCCTGCAGTGGCCTG	0.602000													3	69					0	0	0.150653	0	0
WDR3	10885	broad.mit.edu	37	1	118495284	118495284	+	Splice_Site	SNP	T	T	C			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr1:118495284T>C	ENST00000349139.4	+	19	2197	c.2151_splice	c.e19+1	p.M717_splice		NM_006784.2	NP_006775.1	Q9UNX4	WDR3_HUMAN	WD repeat domain 3	717						nuclear membrane|nucleolus				breast(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(9)|liver(2)|lung(22)|prostate(2)|upper_aerodigestive_tract(1)	49	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		GAAAGGGAGATGGTAAGAACT	0.448000													27	68					0	0	0.804634	0	0
ZCCHC2	54877	broad.mit.edu	37	18	60242215	60242215	+	Silent	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr18:60242215C>T	ENST00000269499.5	+	13	3319	c.2901C>T	c.(2899-2901)ggC>ggT	p.G967G	ZCCHC2_ENST00000586834.1_Silent_p.G646G	NM_017742.4	NP_060212.4	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	967					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(10)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25						ACACCCCAGGCCCTGCCCCGA	0.617000													28	64					0	0	0.740014	0	0
SLC6A10P	386757	broad.mit.edu	37	16	32890639	32890639	+	RNA	SNP	T	T	C	rs79284655		TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr16:32890639T>C	ENST00000330048.5	-	0	3159					NR_003083.2																						ACCAGCGGCTTGTAGTACACA	0.627000													3	49					0	0	0.184627	0	0
KIR3DL1	3811	broad.mit.edu	37	19	55333038	55333038	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr19:55333038C>T	ENST00000391728.4	+	5	707	c.674C>T	c.(673-675)tCt>tTt	p.S225F	KIR3DL1_ENST00000402254.2_Missense_Mutation_p.S225F|KIR3DL1_ENST00000326542.7_Missense_Mutation_p.S225F|KIR3DL1_ENST00000358178.4_Missense_Mutation_p.S130F|KIR3DL1_ENST00000541392.1_Missense_Mutation_p.S225F|KIR3DL1_ENST00000538269.1_Missense_Mutation_p.S225F	NM_013289.2	NP_037421.2			killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1											breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(193;0.0192)		GAGAAACCTTCTCTCTCAGCC	0.557000													114	88					0	0	0.870114	0	0
ZNF792	126375	broad.mit.edu	37	19	35449284	35449284	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr19:35449284C>T	ENST00000404801.1	-	4	1861	c.1475G>A	c.(1474-1476)aGc>aAc	p.S492N	ZNF792_ENST00000605484.1_Missense_Mutation_p.S425N	NM_175872.4	NP_787068.3	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	492					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)	12	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GCTATTGAGGCTGGAGCTCTG	0.493000													61	30					0	0	0.870114	0	0
CALCR	799	broad.mit.edu	37	7	93108821	93108821	+	Splice_Site	SNP	T	T	C			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr7:93108821T>C	ENST00000359558.2	-	5	405		c.e5-2		CALCR_ENST00000421592.1_Splice_Site|CALCR_ENST00000394441.1_Splice_Site|CALCR_ENST00000426151.1_Splice_Site|CALCR_ENST00000360249.4_Splice_Site	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor						activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	GGTTGGGTGCTGTATTAAAAA	0.363000													54	67					0	0	0.870114	0	0
TSPAN14	81619	broad.mit.edu	37	10	82272022	82272022	+	Silent	SNP	T	T	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr10:82272022T>A	ENST00000429989.2	+	6	796	c.573T>A	c.(571-573)ccT>ccA	p.P191P	TSPAN14_ENST00000372164.3_Silent_p.P174P|TSPAN14_ENST00000372158.1_Silent_p.P191P|TSPAN14_ENST00000341863.6_Silent_p.P134P|TSPAN14_ENST00000372156.1_Silent_p.P191P|TSPAN14_ENST00000481124.1_Silent_p.P68P	NM_030927.2	NP_112189.2	Q8NG11	TSN14_HUMAN	tetraspanin 14	191						integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	7			Colorectal(32;0.229)			TGCCAGATCCTGCGGTGAGTT	0.597000													21	6					0	0	0.639603	0	0
DSG4	147409	broad.mit.edu	37	18	28971146	28971146	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr18:28971146G>A	ENST00000359747.4	+	7	819	c.790G>A	c.(790-792)Gat>Aat	p.D264N	RP11-534N16.1_ENST00000581452.1_RNA|DSG4_ENST00000308128.4_Missense_Mutation_p.D264N|RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	264	Cadherin 2.		Missing (in LAH1).		homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AGACGTCAACGATAATTTCCC	0.388000													52	48					0	0	0.870114	0	0
ZNF221	7638	broad.mit.edu	37	19	44470724	44470724	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr19:44470724C>T	ENST00000251269.5	+	6	1398	c.1070C>T	c.(1069-1071)tCc>tTc	p.S357F	ZNF221_ENST00000592350.1_Missense_Mutation_p.S357F|ZNF221_ENST00000587682.1_Missense_Mutation_p.S357F	NM_013359.2	NP_037491.2	Q9UK13	ZN221_HUMAN	zinc finger protein 221	357					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.S357F(1)		central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(11)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	30		Prostate(69;0.0352)				AATAGTCATTCCATGGTCCAC	0.413000													102	81					0	0	0.870114	0	0
NRG1	3084	broad.mit.edu	37	8	32613965	32613965	+	Missense_Mutation	SNP	G	G	T	rs145033301		TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr8:32613965G>T	ENST00000338921.4	+	10	1389	c.872G>T	c.(871-873)cGg>cTg	p.R291L	NRG1_ENST00000356819.4_Missense_Mutation_p.R288L|NRG1_ENST00000519301.1_Missense_Mutation_p.R233L|NRG1_ENST00000523079.1_Missense_Mutation_p.R280L|NRG1_ENST00000405005.2_Missense_Mutation_p.R283L|NRG1_ENST00000341377.5_3'UTR|NRG1_ENST00000287840.5_Missense_Mutation_p.R283L|NRG1_ENST00000287845.5_Missense_Mutation_p.R254L|NRG1_ENST00000539990.1_Missense_Mutation_p.R126L|NRG1_ENST00000521670.1_Missense_Mutation_p.R283L|NRG1_ENST00000287842.3_Missense_Mutation_p.R280L			Q02297	NRG1_HUMAN	neuregulin 1	283					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(1)|skin(1)	39		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		CAGAGCCTTCGGTCTGAACGA	0.453000													3	82					0.00909568	0.00958924	0.150653	1	0
DYNC1H1	1778	broad.mit.edu	37	14	102476715	102476715	+	Silent	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr14:102476715C>T	ENST00000360184.4	+	31	6488	c.6324C>T	c.(6322-6324)atC>atT	p.I2108I		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	2108					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						GAGAGAGAATCCAGAAGATAA	0.463000													26	30					0	0	0.740014	0	0
MYH8	4626	broad.mit.edu	37	17	10310124	10310124	+	Splice_Site	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr17:10310124C>T	ENST00000403437.2	-	19	2148	c.2053_splice	c.e19-1	p.G685_splice	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	685	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						TTCCATTGCCCCTAAAAATAT	0.418000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				11	16					0	0	0.361761	0	0
FBXO31	79791	broad.mit.edu	37	16	87417077	87417077	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr16:87417077G>A	ENST00000311635.7	-	1	286	c.274C>T	c.(274-276)Cag>Tag	p.Q92*	FBXO31_ENST00000563956.1_5'UTR	NM_024735.3	NP_079011.3	Q5XUX0	FBX31_HUMAN	F-box protein 31	92	F-box.				cell cycle|cyclin catabolic process|mitotic cell cycle G1/S transition DNA damage checkpoint|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex	cyclin binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	17				BRCA - Breast invasive adenocarcinoma(80;0.0272)		GTGCAGACCTGGGCCAAGCTG	0.736000													5	7					0	0	0.248553	0	0
DSG3	1830	broad.mit.edu	37	18	29054229	29054229	+	Silent	SNP	C	C	T	rs142612259	byFrequency	TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr18:29054229C>T	ENST00000257189.4	+	15	2330	c.2247C>T	c.(2245-2247)ttC>ttT	p.F749F		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	749					cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CTTCAGGATTCGGAGCAGCCA	0.537000													25	31					0	0	0.681144	0	0
WWC1	23286	broad.mit.edu	37	5	167850881	167850881	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr5:167850881C>T	ENST00000265293.4	+	11	2120	c.1618C>T	c.(1618-1620)Ctc>Ttc	p.L540F	WWC1_ENST00000521089.1_Missense_Mutation_p.L540F	NM_001161661.1|NM_001161662.1|NM_015238.2	NP_001155133.1|NP_001155134.1|NP_056053.1	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1	540					cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(1)|skin(4)	43	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		ACGTTCCTCTCTCTCCTCCCC	0.632000													27	68					0	0	0.779181	0	0
TEAD4	7004	broad.mit.edu	37	12	3147221	3147221	+	Missense_Mutation	SNP	A	A	G			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr12:3147221A>G	ENST00000359864.2	+	11	1175	c.985A>G	c.(985-987)Acc>Gcc	p.T329A	TEAD4_ENST00000358409.2_Missense_Mutation_p.T286A|TEAD4_ENST00000397122.2_Missense_Mutation_p.T200A	NM_003213.3	NP_003204.2	Q15561	TEAD4_HUMAN	TEA domain family member 4	329					hippo signaling cascade|muscle organ development|skeletal system development		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	10	Ovarian(42;0.211)		OV - Ovarian serous cystadenocarcinoma(31;0.000563)|COAD - Colon adenocarcinoma(12;0.0831)			CATGATCATCACCTGCTCCAC	0.587000													21	34					0	0	0.608945	0	0
NLRC5	84166	broad.mit.edu	37	16	57060787	57060787	+	Silent	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr16:57060787C>T	ENST00000436936.1	+	6	2157	c.1932C>T	c.(1930-1932)ttC>ttT	p.F644F	NLRC5_ENST00000539144.1_Silent_p.F644F|NLRC5_ENST00000308149.7_Silent_p.F644F|NLRC5_ENST00000262510.6_Silent_p.F644F			Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	644					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				TCCACAATTTCCCACTGACCT	0.587000													70	68					0	0	0.870114	0	0
CLCA2	9635	broad.mit.edu	37	1	86916377	86916377	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr1:86916377G>A	ENST00000370565.4	+	12	2278	c.2116G>A	c.(2116-2118)Ggg>Agg	p.G706R	CLCA2_ENST00000498802.1_3'UTR	NM_006536.5	NP_006527.1	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2	706					cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			NS(2)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	42		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		CTCTATTCCAGGGAGTCATGC	0.423000													54	91					0	0	0.870114	0	0
NRP1	8829	broad.mit.edu	37	10	33502319	33502319	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr10:33502319C>T	ENST00000265371.4	-	10	2134	c.1609G>A	c.(1609-1611)Gcg>Acg	p.A537T	NRP1_ENST00000374821.5_Missense_Mutation_p.A537T|NRP1_ENST00000374822.4_Missense_Mutation_p.A537T|RP11-342D11.2_ENST00000451530.1_RNA|NRP1_ENST00000395995.1_Missense_Mutation_p.A537T|NRP1_ENST00000374867.2_Missense_Mutation_p.A537T|NRP1_ENST00000466932.1_Splice_Site|NRP1_ENST00000374823.5_Missense_Mutation_p.A537T|NRP1_ENST00000374816.3_Missense_Mutation_p.A537T			O14786	NRP1_HUMAN	neuropilin 1	537	F5/8 type C 2.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	48					Palifermin(DB00039)|Pegaptanib(DB04895)	CTCACCTTCGCCTTGCGTTTG	0.527000													98	54					0	0	0.870114	0	0
RYR2	6262	broad.mit.edu	37	1	237664122	237664122	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr1:237664122G>A	ENST00000366574.2	+	21	2632	c.2315G>A	c.(2314-2316)gGa>gAa	p.G772E	RYR2_ENST00000542537.1_Missense_Mutation_p.G756E|RYR2_ENST00000360064.6_Missense_Mutation_p.G770E	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	772	B30.2/SPRY 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CGAATTAATGGACAACCTGTT	0.403000													41	107					0	0	0.847076	0	0
UCKL1	54963	broad.mit.edu	37	20	62572210	62572210	+	Splice_Site	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr20:62572210C>T	ENST00000369908.5	-	11	1371		c.e11-1		UCKL1_ENST00000354216.6_Splice_Site|UCKL1_ENST00000358711.3_Splice_Site|UCKL1_ENST00000369892.3_Splice_Site	NM_001193379.1	NP_001180308.1	Q9NWZ5	UCKL1_HUMAN	uridine-cytidine kinase 1-like 1						interspecies interaction between organisms	endoplasmic reticulum|nucleus	ATP binding|phosphotransferase activity, alcohol group as acceptor|protein binding|uridine kinase activity			endometrium(3)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	8	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					CGACGCAGTCCTGTGGGGTGC	0.682000													31	22					0	0	0.827153	0	0
CCDC64B	146439	broad.mit.edu	37	16	3080465	3080465	+	Silent	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr16:3080465C>T	ENST00000573514.1	-	3	2316	c.126G>A	c.(124-126)cgG>cgA	p.R42R	CCDC64B_ENST00000389347.4_Silent_p.R249R|CCDC64B_ENST00000572449.1_Silent_p.R249R			A1A5D9	BICR2_HUMAN	coiled-coil domain containing 64B	249										breast(1)|endometrium(2)|large_intestine(1)	4						GGCTGTGCTCCCGCCGCTCCC	0.652000													13	9					0	0	0.500413	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554138	140554138	+	Silent	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr5:140554138G>A	ENST00000231137.3	+	1	1896	c.1722G>A	c.(1720-1722)gaG>gaA	p.E574E		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		574	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTGCACCGAGCCGTTGCCCC	0.701000													74	44					0	0	0.870114	0	0
USP6	9098	broad.mit.edu	37	17	5041493	5041493	+	Missense_Mutation	SNP	G	G	A	rs145087393	byFrequency	TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr17:5041493G>A	ENST00000574788.1	+	21	3233	c.1003G>A	c.(1003-1005)Gat>Aat	p.D335N	USP6_ENST00000332776.4_Missense_Mutation_p.D335N|USP6_ENST00000304328.5_De_novo_Start_InFrame|USP6_ENST00000250066.6_Missense_Mutation_p.D335N			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	335					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						GGCCATGAACGATGACACCGT	0.577000			T	"""COL1A1, CDH11, ZNF9, OMD"""	aneurysmal bone cysts								55	76					0	0	0.870114	0	0
STAMBPL1	57559	broad.mit.edu	37	10	90732959	90732959	+	Silent	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr10:90732959G>A	ENST00000371927.3	+	11	2233	c.1275G>A	c.(1273-1275)ggG>ggA	p.G425G	ACTA2_ENST00000458208.1_Intron			Q96FJ0	STALP_HUMAN	STAM binding protein-like 1	0							metal ion binding|metallopeptidase activity|protein binding			breast(2)|endometrium(1)|large_intestine(2)|liver(2)|lung(2)|ovary(1)|skin(1)	11		Colorectal(252;0.0381)		Colorectal(12;6.38e-05)|COAD - Colon adenocarcinoma(12;7.75e-05)		TCCTTTCTGGGATAATTTCTG	0.433000													49	26					0	0	0.870114	0	0
VCAN	1462	broad.mit.edu	37	5	82817123	82817123	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr5:82817123C>T	ENST00000265077.3	+	7	3563	c.2998C>T	c.(2998-3000)Ccc>Tcc	p.P1000S	VCAN_ENST00000502527.2_Intron|VCAN_ENST00000512590.2_Missense_Mutation_p.P952S|VCAN_ENST00000343200.5_Intron|VCAN_ENST00000342785.4_Missense_Mutation_p.P1000S	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	1000	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TCTAGGTGAACCCTCTCAAGA	0.428000													16	48					0	0	0.557998	0	0
LSG1	55341	broad.mit.edu	37	3	194379705	194379705	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr3:194379705G>A	ENST00000265245.5	-	7	1054	c.740C>T	c.(739-741)cCc>cTc	p.P247L		NM_018385.2	NP_060855.2	Q9H089	LSG1_HUMAN	large 60S subunit nuclear export GTPase 1	247					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity			breast(2)|endometrium(3)|large_intestine(2)|lung(9)	16	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		ACCATTCAGGGGAATGGCTCC	0.458000													48	161					0	0	0.870114	0	0
DNAH9	1770	broad.mit.edu	37	17	11840675	11840675	+	Missense_Mutation	SNP	G	G	A	rs148626653		TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr17:11840675G>A	ENST00000262442.3	+	66	12564	c.12496G>A	c.(12496-12498)Gat>Aat	p.D4166N	DNAH9_ENST00000396001.2_Missense_Mutation_p.D478N|DNAH9_ENST00000454412.2_Missense_Mutation_p.D4090N	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	4166					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TCAGTACATCGATGCTGAGCT	0.547000													24	97					0	0	0.706142	0	0
BPIFB3	359710	broad.mit.edu	37	20	31656748	31656748	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr20:31656748G>A	ENST00000375494.3	+	10	1118	c.1118G>A	c.(1117-1119)gGg>gAg	p.G373E		NM_182658.1	NP_872599.1	P59826	LPLC3_HUMAN	BPI fold containing family B, member 3	373					innate immune response	cytoplasm|extracellular region	lipid binding|protein binding										GTCCCTAAGGGGACCCCTGAA	0.592000													27	66					0	0	0.760397	0	0
GABRA5	2558	broad.mit.edu	37	15	27128562	27128562	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr15:27128562C>T	ENST00000335625.5	+	6	1243	c.355C>T	c.(355-357)Cct>Tct	p.P119S	GABRA5_ENST00000557449.1_Intron|GABRB3_ENST00000541819.2_Intron|GABRA5_ENST00000355395.5_Missense_Mutation_p.P119S|GABRA5_ENST00000400081.3_Missense_Mutation_p.P119S	NM_000810.3	NP_000801.1	P31644	GBRA5_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 5	119					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(26)|ovary(1)|upper_aerodigestive_tract(1)	49		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GCAGCGCCTCCCTCTCAACAA	0.532000													59	55					0	0	0.870114	0	0
MMP12	4321	broad.mit.edu	37	11	102745631	102745631	+	RNA	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr11:102745631C>T	ENST00000532855.1	-	0	133							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	GCTCCAGAAGCAGTGGCCTGC	0.408000													5	10					0	0	0.278610	0	0
CDH10	1008	broad.mit.edu	37	5	24535308	24535308	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr5:24535308C>T	ENST00000264463.4	-	5	1234	c.727G>A	c.(727-729)Ggc>Agc	p.G243S		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	243	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		ATCTGGCCGCCCATGTCTTTG	0.473000										HNSCC(23;0.051)			24	59					0	0	0.681144	0	0
GHR	2690	broad.mit.edu	37	5	42711475	42711475	+	Splice_Site	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr5:42711475G>A	ENST00000230882.4	+	7	974		c.e7+1		GHR_ENST00000357703.3_Splice_Site|GHR_ENST00000537449.1_Splice_Site	NM_000163.4|NM_001242399.2|NM_001242400.2|NM_001242401.3|NM_001242402.2|NM_001242403.2|NM_001242404.2|NM_001242405.2|NM_001242406.2	NP_000154.1|NP_001229328.1|NP_001229329.1|NP_001229330.1|NP_001229331.1|NP_001229332.1|NP_001229333.1|NP_001229334.1|NP_001229335.1	P10912	GHR_HUMAN	growth hormone receptor						2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TGTGAAGAAGGTAAAAGAAAT	0.378000													25	61					0	0	0.667858	0	0
LY6H	4062	broad.mit.edu	37	8	144239833	144239833	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr8:144239833G>A	ENST00000414417.2	-	5	553	c.320C>T	c.(319-321)tCa>tTa	p.S107L	LY6H_ENST00000430474.2_Missense_Mutation_p.S86L|LY6H_ENST00000342752.4_Missense_Mutation_p.S107L	NM_001130478.1	NP_001123950.1	O94772	LY6H_HUMAN	lymphocyte antigen 6 complex, locus H	86					nervous system development|organ morphogenesis	anchored to membrane|plasma membrane				endometrium(1)|lung(1)|stomach(2)	4	all_cancers(97;6.49e-11)|all_epithelial(106;2.77e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					CAGATAGTCTGAGAAAAAGTG	0.547000													5	107					0	0	0.217242	0	0
ZFYVE20	64145	broad.mit.edu	37	3	15115903	15115903	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr3:15115903G>A	ENST00000253699.3	-	14	2354	c.1741C>T	c.(1741-1743)Cca>Tca	p.P581S	ZFYVE20_ENST00000476527.2_Missense_Mutation_p.P581S	NM_022340.2	NP_071735.2	Q9H1K0	RBNS5_HUMAN	zinc finger, FYVE domain containing 20	581	Necessary for the interaction with EHD1.				blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			NS(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|skin(3)|stomach(1)|urinary_tract(2)	26						GTGCTGCTTGGAACTGGGGAA	0.592000													19	11					0	0	0.608945	0	0
ACSS3	79611	broad.mit.edu	37	12	81503432	81503432	+	Silent	SNP	T	T	C			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr12:81503432T>C	ENST00000548058.1	+	2	1315	c.405T>C	c.(403-405)agT>agC	p.S135S	RP11-543H12.1_ENST00000547123.1_RNA|ACSS3_ENST00000261206.3_Silent_p.S134S			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	135						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						TCTATGACAGTCCTGTTACAA	0.313000													43	15					0	0	0.870114	0	0
FBXW8	26259	broad.mit.edu	37	12	117461999	117461999	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr12:117461999C>T	ENST00000455858.2	+	9	1290	c.1217C>T	c.(1216-1218)tCc>tTc	p.S406F	FBXW8_ENST00000309909.5_Missense_Mutation_p.S472F	NM_012174.1|NM_153348.2	NP_036306.1|NP_699179.2	Q8N3Y1	FBXW8_HUMAN	F-box and WD repeat domain containing 8	472							protein binding			endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	22	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0353)		CTGTCGCTCTCCGCCCATCAG	0.577000													43	11					0	0	0.870114	0	0
PLA2G4D	283748	broad.mit.edu	37	15	42373218	42373218	+	Silent	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr15:42373218G>A	ENST00000290472.3	-	12	1165	c.1071C>T	c.(1069-1071)ttC>ttT	p.F357F		NM_178034.3	NP_828848.3	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD (cytosolic)	357	PLA2c.				phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		AGATGCCACTGAAGTAGGTCA	0.612000													19	19					0	0	0.608945	0	0
PTGIR	5739	broad.mit.edu	37	19	47124917	47124917	+	Missense_Mutation	SNP	T	T	G			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr19:47124917T>G	ENST00000291294.2	-	3	914	c.781A>C	c.(781-783)Acc>Ccc	p.T261P	PTGIR_ENST00000598865.1_Missense_Mutation_p.T49P|PTGIR_ENST00000597185.1_5'UTR|PTGIR_ENST00000594275.1_Missense_Mutation_p.T18P	NM_000960.3	NP_000951.1	P43119	PI2R_HUMAN	prostaglandin I2 (prostacyclin) receptor (IP)	261					cell-cell signaling|G-protein signaling, coupled to cyclic nucleotide second messenger|platelet activation	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	13		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000327)|all cancers(93;0.000641)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0331)	Dinoprost Tromethamine(DB01160)|Dinoprostone(DB00917)|Epoprostenol(DB01240)|Iloprost(DB01088)|Misoprostol(DB00929)	ACAGCCTGGGTGAAGCAGCGG	0.637000													29	16					0	0	0.769981	0	0
HR	55806	broad.mit.edu	37	8	21982903	21982903	+	Missense_Mutation	SNP	G	G	C			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr8:21982903G>C	ENST00000381418.4	-	5	3151	c.1671C>G	c.(1669-1671)caC>caG	p.H557Q	HR_ENST00000312841.8_Missense_Mutation_p.H557Q	NM_005144.4	NP_005135.2	O43593	HAIR_HUMAN	hair growth associated	557							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	27		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		CACTGAGCAGGTGCTTGGCGA	0.687000													12	6					0	0	0.479597	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				34	72					0	0	0.827153	0	0
UGT3A2	167127	broad.mit.edu	37	5	36049236	36049236	+	Silent	SNP	G	G	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr5:36049236G>T	ENST00000282507.3	-	4	699	c.598C>A	c.(598-600)Cga>Aga	p.R200R	UGT3A2_ENST00000513300.1_Silent_p.R166R|UGT3A2_ENST00000504954.1_Intron|UGT3A2_ENST00000545528.1_Intron	NM_174914.3	NP_777574.2	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	200						integral to membrane	glucuronosyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	43	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TTCTTCACTCGGCCCCAGAAG	0.453000													3	80					0.150653	0.156404	0.150653	1	0
MEGF8	1954	broad.mit.edu	37	19	42839252	42839252	+	Silent	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr19:42839252G>A	ENST00000334370.4	+	4	1259	c.624G>A	c.(622-624)gaG>gaA	p.E208E	MEGF8_ENST00000251268.6_Silent_p.E208E	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	208						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				ACCTGTGGGAGAACCAGGGGG	0.642000													13	15					0	0	0.520397	0	0
ZNF197	10168	broad.mit.edu	37	3	44684223	44684223	+	Missense_Mutation	SNP	G	G	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr3:44684223G>T	ENST00000396058.1	+	5	1768	c.1601G>T	c.(1600-1602)gGg>gTg	p.G534V	ZNF197_ENST00000344387.4_Missense_Mutation_p.G534V|ZNF197_ENST00000383744.4_Intron|ZNF197_ENST00000383745.2_Intron|RP11-944L7.4_ENST00000457331.1_RNA			O14709	ZN197_HUMAN	zinc finger protein 197	534					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(1)	25				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		ATCCACTCTGGGGAAAAACCC	0.433000													7	93					2.52707e-12	2.77162e-12	0.335167	1	0
PAQR8	85315	broad.mit.edu	37	6	52268794	52268794	+	Missense_Mutation	SNP	C	C	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr6:52268794C>A	ENST00000442253.2	+	2	957	c.783C>A	c.(781-783)ttC>ttA	p.F261L	PAQR8_ENST00000360726.3_Missense_Mutation_p.F261L	NM_133367.4	NP_588608.1	Q8TEZ7	MPRB_HUMAN	progestin and adipoQ receptor family member VIII	261					cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|skin(1)|urinary_tract(2)	17	Lung NSC(77;0.0875)					GCGCTTATTTCTTCTCCTGCC	0.572000													13	61					1.3612e-06	1.46924e-06	0.479597	1	0
PGLYRP3	114771	broad.mit.edu	37	1	153270485	153270485	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr1:153270485G>A	ENST00000290722.1	-	7	1025	c.973C>T	c.(973-975)Cct>Tct	p.P325S		NM_052891.1	NP_443123.1	Q96LB9	PGRP3_HUMAN	peptidoglycan recognition protein 3	325					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(1)|liver(1)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	28	all_lung(78;3.35e-32)|Lung NSC(65;1.22e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCCTGCCCAGGGGACAGGATG	0.597000													58	261					0	0	0.870114	0	0
UBBP4	23666	broad.mit.edu	37	17	21731075	21731075	+	Missense_Mutation	SNP	T	T	G	rs111568648		TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr17:21731075T>G	ENST00000584755.1	+	2	774	c.377T>G	c.(376-378)cTg>cGg	p.L126R	UBBP4_ENST00000583708.1_3'UTR|UBBP4_ENST00000578713.1_Missense_Mutation_p.L126R|UBBP4_ENST00000584398.1_3'UTR																endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GGCAAGCAGCTGGAAGATGGC	0.537000													3	65					0	0	0.115264	0	0
MUC16	94025	broad.mit.edu	37	19	9073897	9073897	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr19:9073897C>T	ENST00000397910.4	-	3	13752	c.13549G>A	c.(13549-13551)Gag>Aag	p.E4517K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4519	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.E4517K(2)|p.E150K(1)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCCAGTATCTCATTTGATGGA	0.433000													34	49					0	0	0.840704	0	0
PKHD1	5314	broad.mit.edu	37	6	51512867	51512867	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr6:51512867G>A	ENST00000371117.3	-	63	11635	c.11360C>T	c.(11359-11361)tCa>tTa	p.S3787L		NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	3787					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CAGGGAAGCTGAAATTGTCCA	0.423000													21	65					0	0	0.693898	0	0
SLC22A24	283238	broad.mit.edu	37	11	62911066	62911066	+	Silent	SNP	A	A	G			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr11:62911066A>G	ENST00000417740.1	-	1	627	c.186T>C	c.(184-186)aaT>aaC	p.N62N	SLC22A10_ENST00000525620.1_Intron|SLC22A24_ENST00000326192.5_Silent_p.N62N	NM_001136506.2	NP_001129978.2			solute carrier family 22, member 24											kidney(1)|stomach(1)	2						TCCCGGTATCATTGTCAGACA	0.522000													8	20					0	0	0.335167	0	0
CDK12	51755	broad.mit.edu	37	17	37665992	37665992	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr17:37665992C>T	ENST00000447079.4	+	7	2677	c.2644C>T	c.(2644-2646)Cgg>Tgg	p.R882W	CDK12_ENST00000430627.2_Missense_Mutation_p.R882W	NM_015083.1|NM_016507.2	NP_055898.1|NP_057591.2	Q9NYV4	CDK12_HUMAN	cyclin-dependent kinase 12	882	Protein kinase.				mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity	p.R882R(1)		NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						TGGACTTGCTCGGCTCTATAA	0.348000			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)			41	72					0	0	0.870114	0	0
CORIN	10699	broad.mit.edu	37	4	47663875	47663875	+	Splice_Site	SNP	T	T	C			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr4:47663875T>C	ENST00000273857.4	-	12	1589		c.e12-2		CORIN_ENST00000502252.1_Splice_Site|CORIN_ENST00000505909.1_Splice_Site|CORIN_ENST00000508498.1_Splice_Site|CORIN_ENST00000504584.1_Splice_Site	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase						peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						CACAATGCCCTAGATGAACAA	0.408000													4	17					0	0	0.217242	0	0
MAP2K1	5604	broad.mit.edu	37	15	66729162	66729162	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr15:66729162C>T	ENST00000307102.5	+	3	901	c.370C>T	c.(370-372)Ccg>Tcg	p.P124S		NM_002755.3	NP_002746.1	Q02750	MP2K1_HUMAN	mitogen-activated protein kinase kinase 1	124	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|plasma membrane	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.P124S(8)		endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(8)|urinary_tract(1)	20						GTGCAACTCTCCGTACATCGT	0.507000													22	54					0	0	0.654019	0	0
CP	1356	broad.mit.edu	37	3	148924059	148924059	+	Silent	SNP	C	C	T	rs142503847		TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr3:148924059C>T	ENST00000264613.6	-	6	1366	c.1104G>A	c.(1102-1104)ggG>ggA	p.G368G		NM_000096.3	NP_000087.1	P00450	CERU_HUMAN	ceruloplasmin (ferroxidase)	368					cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			breast(6)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	TAACATGCTTCCCACGGATAT	0.423000													59	53					0	0	0.870114	0	0
PTPRT	11122	broad.mit.edu	37	20	40877386	40877386	+	Silent	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr20:40877386G>A	ENST00000373198.3	-	15	2545	c.2310C>T	c.(2308-2310)atC>atT	p.I770I	PTPRT_ENST00000373187.1_Silent_p.I751I|PTPRT_ENST00000373201.1_Silent_p.I751I|PTPRT_ENST00000373193.3_Silent_p.I751I|PTPRT_ENST00000356100.2_Silent_p.I770I|PTPRT_ENST00000373184.1_Silent_p.I751I|PTPRT_ENST00000373190.1_Silent_p.I751I	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	751					homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GGAGGCCAGCGATCACGCCAG	0.552000													19	49					0	0	0.624587	0	0
EDNRA	1909	broad.mit.edu	37	4	148460990	148460990	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr4:148460990G>A	ENST00000324300.5	+	6	1437	c.922G>A	c.(922-924)Gtt>Att	p.V308I	EDNRA_ENST00000358556.4_Missense_Mutation_p.V199I|EDNRA_ENST00000339690.5_3'UTR|EDNRA_ENST00000511804.1_Missense_Mutation_p.V83I|EDNRA_ENST00000503721.1_3'UTR|EDNRA_ENST00000506066.1_Missense_Mutation_p.V199I	NM_001957.3	NP_001948.1	P25101	EDNRA_HUMAN	endothelin receptor type A	308					activation of adenylate cyclase activity|artery smooth muscle contraction|cell proliferation|glucose transport|respiratory gaseous exchange	integral to plasma membrane	endothelin-A receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(3)|ovary(1)	17	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.154)	Bosentan(DB00559)	GGCAAAAACAGTTTTCTGCTT	0.363000													41	55					0	0	0.870114	0	0
TUBB8	347688	broad.mit.edu	37	10	93851	93851	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr10:93851C>T	ENST00000447903.2	-	4	580	c.265G>A	c.(265-267)Gac>Aac	p.D89N	TUBB8_ENST00000413237.3_5'UTR|TUBB8_ENST00000309812.4_Missense_Mutation_p.D161N|TUBB8_ENST00000332708.5_3'UTR			Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 class VIII	161					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			NS(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(12)|ovary(2)|prostate(3)|skin(3)|stomach(1)	32		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		ATGATCCTGTCTGGGTACTCC	0.597000													33	75					0	0	0.870114	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518355	113518355	+	Missense_Mutation	SNP	G	G	T	rs35449651	byFrequency	TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr7:113518355G>T	ENST00000284601.3	-	4	2860	c.2792C>A	c.(2791-2793)gCa>gAa	p.A931E		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	931			A -> E (in NIDDM; dbSNP:rs35449651).		glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TACAGCAATTGCCTGCTCATT	0.378000													52	75					1.53582e-20	1.71207e-20	0.870114	1	0
MMRN1	22915	broad.mit.edu	37	4	90856722	90856722	+	Missense_Mutation	SNP	A	A	G			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr4:90856722A>G	ENST00000394980.1	+	7	2210	c.1891A>G	c.(1891-1893)Aag>Gag	p.K631E	MMRN1_ENST00000264790.2_Missense_Mutation_p.K631E|MMRN1_ENST00000508372.1_Missense_Mutation_p.K373E|MMRN1_ENST00000394981.1_Intron			Q13201	MMRN1_HUMAN	multimerin 1	631					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		AATGGACAATAAGATGGACAA	0.363000													4	96					0	0	0.150653	0	0
DSG4	147409	broad.mit.edu	37	18	28991408	28991408	+	Silent	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr18:28991408G>A	ENST00000359747.4	+	14	2438	c.2409G>A	c.(2407-2409)tcG>tcA	p.S803S	DSG4_ENST00000308128.4_Silent_p.S784S|RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	784					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GCTACTTCTCGGAGGTAATGC	0.473000													45	31					0	0	0.870114	0	0
RECK	8434	broad.mit.edu	37	9	36118962	36118962	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr9:36118962C>T	ENST00000377966.3	+	18	3028	c.2462C>T	c.(2461-2463)cCg>cTg	p.P821L		NM_021111.2	NP_066934.1	O95980	RECK_HUMAN	reversion-inducing-cysteine-rich protein with kazal motifs	821						anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			ATCATCCCACCGGGTAGGCTG	0.557000													27	55					0	0	0.729181	0	0
PDS5B	23047	broad.mit.edu	37	13	33306319	33306319	+	Silent	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr13:33306319G>A	ENST00000315596.10	+	20	2391	c.2205G>A	c.(2203-2205)gcG>gcA	p.A735A		NM_015032.3	NP_055847.1	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	735					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding	p.A735A(1)		NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|lung(14)|ovary(5)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	62		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		GTATCCATGCGATATTTTCTA	0.313000													15	30					0	0	0.539581	0	0
FLG2	388698	broad.mit.edu	37	1	152328911	152328911	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr1:152328911G>A	ENST00000388718.5	-	3	1423	c.1351C>T	c.(1351-1353)Caa>Taa	p.Q451*	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	451	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCACAAGTTTGACCTGAGCCA	0.478000													104	94					0	0	0.870114	0	0
CYP2D7	1564	broad.mit.edu	37	22	42538870	42538870	+	RNA	SNP	A	A	C	rs2982057	by1000genomes	TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr22:42538870A>C	ENST00000358097.4	-	0	449				CYP2D7P1_ENST00000433992.1_RNA|CYP2D7P1_ENST00000424775.1_RNA																endometrium(1)	1						CCATAGCGCGACAGGAACACC	0.687000													4	28					0	0	0.184627	0	0
MYT1L	23040	broad.mit.edu	37	2	1926514	1926514	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr2:1926514C>T	ENST00000399161.2	-	10	1774	c.1027G>A	c.(1027-1029)Gag>Aag	p.E343K	MYT1L_ENST00000428368.2_Missense_Mutation_p.E343K	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	343					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GGGTTGGTCTCACTGAGCTTC	0.557000													7	37					0	0	0.278610	0	0
SH3BP1	23616	broad.mit.edu	37	22	38041502	38041502	+	Missense_Mutation	SNP	G	G	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr22:38041502G>T	ENST00000599616.1	+	8	717	c.717G>T	c.(715-717)gaG>gaT	p.E239D	SH3BP1_ENST00000495174.1_3'UTR|SH3BP1_ENST00000336738.5_Missense_Mutation_p.E303D|SH3BP1_ENST00000357436.4_Missense_Mutation_p.E303D|Z83844.1_ENST00000456099.1_RNA|SH3BP1_ENST00000442465.2_Missense_Mutation_p.E303D			Q9Y3L3	3BP1_HUMAN	SH3-domain binding protein 1	303	BAR.				signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	Melanoma(58;0.0574)					TGCTTTCTGAGGGCATGAAGG	0.647000													30	59					1.42033e-22	1.59641e-22	0.796494	1	0
SLC22A11	55867	broad.mit.edu	37	11	64338456	64338456	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr11:64338456C>T	ENST00000301891.4	+	10	1969	c.1595C>T	c.(1594-1596)tCa>tTa	p.S532L	SLC22A11_ENST00000377581.3_Missense_Mutation_p.S463L|SLC22A11_ENST00000377585.3_Missense_Mutation_p.S424L	NM_018484.2	NP_060954.1	Q9NSA0	S22AB_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 11	532					urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23					Probenecid(DB01032)	TCTAGGAAATCAACAGCAGCC	0.512000													32	63					0	0	0.812448	0	0
PLCE1	51196	broad.mit.edu	37	10	95995871	95995871	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr10:95995871G>A	ENST00000260766.3	+	7	3048	c.2414G>A	c.(2413-2415)cGa>cAa	p.R805Q	PLCE1_ENST00000371380.2_Missense_Mutation_p.R805Q|PLCE1_ENST00000371375.1_Missense_Mutation_p.R497Q|PLCE1_ENST00000371385.3_Missense_Mutation_p.R497Q	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	805					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				GATAAAAGCCGATGGCAGTAA	0.463000													9	4					0	0	0.361761	0	0
KCNQ1	3784	broad.mit.edu	37	11	2592606	2592606	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr11:2592606G>A	ENST00000155840.5	+	4	764	c.656G>A	c.(655-657)gGg>gAg	p.G219E	KCNQ1_ENST00000335475.5_Missense_Mutation_p.G92E	NM_000218.2	NP_000209.2	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 1	219					blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)	21		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	GGCTCCAAGGGGCAGGTGTTT	0.677000													30	63					0	0	0.788014	0	0
SLC1A7	6512	broad.mit.edu	37	1	53558324	53558324	+	Silent	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr1:53558324G>A	ENST00000371494.4	-	7	1060	c.933C>T	c.(931-933)atC>atT	p.I311I		NM_006671.4	NP_006662.3	O00341	EAA5_HUMAN	solute carrier family 1 (glutamate transporter), member 7	311						integral to membrane|plasma membrane	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Colorectal(1306;0.234)	L-Glutamic Acid(DB00142)	GCAGGGGCAGGATAAAGAGCC	0.597000													24	44					0	0	0.706142	0	0
KNG1	3827	broad.mit.edu	37	3	186459342	186459342	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr3:186459342C>T	ENST00000265023.4	+	10	1369	c.1157C>T	c.(1156-1158)tCa>tTa	p.S386L	KNG1_ENST00000447445.1_Missense_Mutation_p.S350L|RP11-573D15.8_ENST00000354642.2_RNA|KNG1_ENST00000287611.2_Missense_Mutation_p.S386L|RP11-573D15.8_ENST00000599314.1_RNA	NM_001102416.2	NP_001095886.1	P01042	KNG1_HUMAN	kininogen 1	386					blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			endometrium(1)|lung(15)|prostate(1)|skin(2)|stomach(2)	21	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	CCAGGTTTTTCACCTTTCCGA	0.383000													39	27					0	0	0.870114	0	0
LTBP2	4053	broad.mit.edu	37	14	74972782	74972782	+	Silent	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr14:74972782C>T	ENST00000261978.4	-	28	4532	c.4146G>A	c.(4144-4146)caG>caA	p.Q1382Q	LTBP2_ENST00000556690.1_Silent_p.Q1338Q	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	1382	EGF-like 16; calcium-binding (Potential).				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		AGTGCCCCTCCTGGGCATCGT	0.627000													62	63					0	0	0.870114	0	0
TTN	7273	broad.mit.edu	37	2	179517255	179517255	+	Silent	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr2:179517255C>T	ENST00000589042.1	-	202	39281	c.39057G>A	c.(39055-39057)ccG>ccA	p.P13019P	TTN_ENST00000591111.1_Silent_p.P11512P|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Silent_p.P10585P|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11373	Ig-like 86.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAACTTCTTTCGGAGCCTCTG	0.373000													26	67					0	0	0.769981	0	0
TPTE2P2	644623	broad.mit.edu	37	13	52865661	52865661	+	RNA	SNP	C	C	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr13:52865661C>A	ENST00000451298.1	-	0	31				RP11-64P12.8_ENST00000606031.1_RNA																							AAGGATGACACAATTGAATGA	0.289000													9	39					0.000308642	0.000327932	0.479597	1	0
OSBPL9	114883	broad.mit.edu	37	1	52250221	52250221	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr1:52250221G>A	ENST00000371710.3	+	20	2032	c.1850G>A	c.(1849-1851)gGg>gAg	p.G617E	OSBPL9_ENST00000531828.1_Missense_Mutation_p.G434E|OSBPL9_ENST00000462759.1_Missense_Mutation_p.G421E|OSBPL9_ENST00000371714.1_Missense_Mutation_p.G586E|OSBPL9_ENST00000486942.1_Missense_Mutation_p.G421E|OSBPL9_ENST00000428468.1_Missense_Mutation_p.G599E|OSBPL9_ENST00000435686.2_Missense_Mutation_p.G434E|OSBPL9_ENST00000447887.1_Missense_Mutation_p.G609E|OSBPL9_ENST00000530544.1_Missense_Mutation_p.G518E|OSBPL9_ENST00000361556.5_Missense_Mutation_p.G489E|OSBPL9_ENST00000453295.1_Missense_Mutation_p.G582E|OSBPL9_ENST00000337809.4_Missense_Mutation_p.G604E	NM_024586.5|NM_148906.2	NP_078862.4|NP_683704.2	Q96SU4	OSBL9_HUMAN	oxysterol binding protein-like 9	599					lipid transport		lipid binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(3)|pancreas(1)|prostate(3)|skin(1)	18						CCCTTCTATGGGGGCAAGAAG	0.403000													19	45					0	0	0.592651	0	0
OR13H1	347468	broad.mit.edu	37	X	130678233	130678233	+	Silent	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chrX:130678233C>T	ENST00000338616.3	+	1	284	c.186C>T	c.(184-186)ttC>ttT	p.F62F		NM_001004486.1	NP_001004486.1	Q8NG92	O13H1_HUMAN	olfactory receptor, family 13, subfamily H, member 1	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(3)|lung(7)|prostate(1)|skin(1)	15	Acute lymphoblastic leukemia(192;0.000636)					TCTACTTCTTCCTTAGTAACC	0.433000													52	32					0	0	0.870114	0	0
GFRAL	389400	broad.mit.edu	37	6	55216368	55216368	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr6:55216368G>A	ENST00000340465.2	+	5	774	c.688G>A	c.(688-690)Gat>Aat	p.D230N		NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like	230						integral to membrane	receptor activity			NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CTGCCAAAATGATGAATTATG	0.423000													10	28					0	0	0.411799	0	0
MME	4311	broad.mit.edu	37	3	154861348	154861348	+	Silent	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr3:154861348G>A	ENST00000460393.1	+	13	1425	c.1305G>A	c.(1303-1305)gaG>gaA	p.E435E	MME_ENST00000493237.1_Silent_p.E435E|MME_ENST00000462745.1_Silent_p.E435E|MME_ENST00000492661.1_Silent_p.E435E|MME_ENST00000360490.2_Silent_p.E435E	NM_000902.3|NM_007287.2	NP_000893.2|NP_009218.2	P08473	NEP_HUMAN	membrane metallo-endopeptidase	435					cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(31)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	TTGCTGGAGAGAGTAAACATG	0.403000													28	112					0	0	0.812448	0	0
MYOM2	9172	broad.mit.edu	37	8	2017587	2017587	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr8:2017587C>T	ENST00000262113.4	+	8	905	c.764C>T	c.(763-765)cCa>cTa	p.P255L	MYOM2_ENST00000523438.1_Intron	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	255					muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		GACGAGGAACCATTCCGTTCG	0.507000													121	42					0	0	0.870114	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121653532	121653532	+	Missense_Mutation	SNP	T	T	A	rs144360433	byFrequency	TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr7:121653532T>A	ENST00000393386.2	+	12	4843	c.4432T>A	c.(4432-4434)Tct>Act	p.S1478T	PTPRZ1_ENST00000449182.1_Intron	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	1478					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						ATACTCACTATCTGAGAATTC	0.393000													56	61					0	0	0.870114	0	0
KRTAP5-4	387267	broad.mit.edu	37	11	1643237	1643237	+	Silent	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr11:1643237C>T	ENST00000399682.1	-	1	131	c.87G>A	c.(85-87)ggG>ggA	p.G29G		NM_001012709.1	NP_001012727.1	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	29						keratin filament				NS(1)|endometrium(9)|kidney(2)|lung(2)|pancreas(1)|prostate(3)|skin(2)	20		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		agccacagcccccacagccag	0.682000													3	75					0	0	0.115264	0	0
PCNXL3	399909	broad.mit.edu	37	11	65403166	65403166	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr11:65403166C>T	ENST00000355703.3	+	32	5890	c.5351C>T	c.(5350-5352)tCg>tTg	p.S1784L		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	1784						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						ATCTACGTGTCGCCTCTCACC	0.667000													6	9					0	0	0.248553	0	0
EML5	161436	broad.mit.edu	37	14	89093244	89093244	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr14:89093244C>T	ENST00000554922.1	-	35	4926	c.4678G>A	c.(4678-4680)Ggg>Agg	p.G1560R	EML5_ENST00000380664.5_Missense_Mutation_p.G1552R|EML5_ENST00000352093.5_Missense_Mutation_p.G1514R|EML5_ENST00000553320.1_5'UTR	NM_183387.2	NP_899243.1	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like 5	1552						cytoplasm|microtubule				breast(1)|endometrium(3)|kidney(4)|large_intestine(17)|lung(14)|ovary(3)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						CTCAGTAGCCCTTTTTTGCTA	0.468000													30	34					0	0	0.750413	0	0
GABRB3	2562	broad.mit.edu	37	15	26806278	26806278	+	Missense_Mutation	SNP	C	C	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr15:26806278C>A	ENST00000541819.2	-	9	1151	c.1049G>T	c.(1048-1050)cGg>cTg	p.R350L	GABRB3_ENST00000299267.4_Missense_Mutation_p.R294L|GABRB3_ENST00000311550.5_Missense_Mutation_p.R294L|GABRB3_ENST00000545868.1_Missense_Mutation_p.R209L|GABRB3_ENST00000400188.3_Missense_Mutation_p.R223L			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	294					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity	p.R294L(2)|p.R350L(1)		NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CAAGGTCTCCCGAAGGTGGGT	0.478000													5	125					1.23904e-05	1.32685e-05	0.184627	1	0
ZNF878	729747	broad.mit.edu	37	19	12155673	12155673	+	Missense_Mutation	SNP	A	A	C			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr19:12155673A>C	ENST00000602107.1	-	5	683	c.684T>G	c.(682-684)agT>agG	p.S228R	CTD-2006C1.2_ENST00000476474.1_RNA|CTD-2006C1.2_ENST00000591898.1_RNA|ZNF878_ENST00000547628.1_Missense_Mutation_p.S181R|CTD-2006C1.10_ENST00000547473.1_Intron|CTD-2006C1.2_ENST00000591838.1_RNA			C9JN71	ZN878_HUMAN	zinc finger protein 878	181					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|lung(4)|urinary_tract(1)	8						AACTGGGAAAACTGAATGCTT	0.403000													5	204					0	0	0.248553	0	0
SNCAIP	9627	broad.mit.edu	37	5	121780306	121780306	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr5:121780306G>A	ENST00000261367.7	+	10	3040	c.1612G>A	c.(1612-1614)Gaa>Aaa	p.E538K	SNCAIP_ENST00000414317.2_Missense_Mutation_p.E93K|SNCAIP_ENST00000542191.1_Missense_Mutation_p.E49K|SNCAIP_ENST00000503116.2_3'UTR|SNCAIP_ENST00000379536.2_Missense_Mutation_p.E431K|CTC-210G5.1_ENST00000510972.1_RNA|SNCAIP_ENST00000379533.2_Missense_Mutation_p.E538K|CTC-210G5.1_ENST00000509993.1_RNA|SNCAIP_ENST00000379538.3_Missense_Mutation_p.E125K|CTC-210G5.1_ENST00000503529.1_RNA|SNCAIP_ENST00000261368.8_Missense_Mutation_p.E491K|CTC-210G5.1_ENST00000506053.1_RNA|SNCAIP_ENST00000504884.2_3'UTR			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	491					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		CCACGCTGGGGAAAAGCCCTC	0.537000													52	53					0	0	0.870114	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77353946	77353946	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr16:77353946C>T	ENST00000282849.5	-	16	2750	c.2332G>A	c.(2332-2334)Gaa>Aaa	p.E778K		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	778	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TCCTGGATTTCGATGCTTCGG	0.522000													18	40					0	0	0.608945	0	0
CHN1	1123	broad.mit.edu	37	2	175742832	175742832	+	Silent	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr2:175742832G>A	ENST00000409900.3	-	6	598	c.285C>T	c.(283-285)ttC>ttT	p.F95F	CHN1_ENST00000488080.1_Intron|CHN1_ENST00000409156.3_Silent_p.F95F	NM_001822.5	NP_001813.1	P15882	CHIN_HUMAN	chimerin 1	95	SH2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(117;0.226)			AGTAGAGCCTGAAGTTTCTGG	0.383000			T	TAF15	extraskeletal myxoid chondrosarcoma								17	10					0	0	0.624587	0	0
MGAM	8972	broad.mit.edu	37	7	141732710	141732710	+	Splice_Site	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr7:141732710G>A	ENST00000475668.2	+	14	1723		c.e14+1		MGAM_ENST00000549489.2_Splice_Site			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)						polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TTCACTCCCAGTAAGTCTTGG	0.373000													14	20					0	0	0.539581	0	0
KIAA2022	340533	broad.mit.edu	37	X	73963375	73963375	+	Silent	SNP	G	G	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chrX:73963375G>T	ENST00000373468.1	-	3	1668	c.1017C>A	c.(1015-1017)ccC>ccA	p.P339P	KIAA2022_ENST00000055682.5_Silent_p.P339P			Q5QGS0	K2022_HUMAN	KIAA2022	339					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						TAAAGACGCTGGGAAAAAAGT	0.458000													39	22					3.61848e-18	4.00092e-18	0.834066	1	0
BPIFB3	359710	broad.mit.edu	37	20	31656749	31656749	+	Silent	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr20:31656749G>A	ENST00000375494.3	+	10	1119	c.1119G>A	c.(1117-1119)ggG>ggA	p.G373G		NM_182658.1	NP_872599.1	P59826	LPLC3_HUMAN	BPI fold containing family B, member 3	373					innate immune response	cytoplasm|extracellular region	lipid binding|protein binding										TCCCTAAGGGGACCCCTGAAT	0.597000													26	66					0	0	0.740014	0	0
CCKBR	887	broad.mit.edu	37	11	6291015	6291015	+	Missense_Mutation	SNP	A	A	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr11:6291015A>T	ENST00000525462.1	+	2	271	c.268A>T	c.(268-270)Aat>Tat	p.N90Y	CCKBR_ENST00000531712.1_3'UTR|CCKBR_ENST00000334619.2_Missense_Mutation_p.N90Y|CCKBR_ENST00000532715.1_Intron|CCKBR_ENST00000525014.1_Missense_Mutation_p.N90Y			P32239	GASR_HUMAN	cholecystokinin B receptor	90					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			NS(2)|breast(2)|endometrium(4)|kidney(13)|large_intestine(10)|lung(22)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	GACTGTCACCAATGCCTTCCT	0.552000													50	117					0	0	0.870114	0	0
KCNA1	3736	broad.mit.edu	37	12	5021217	5021217	+	Missense_Mutation	SNP	G	G	A			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr12:5021217G>A	ENST00000382545.3	+	2	1780	c.673G>A	c.(673-675)Gaa>Aaa	p.E225K	KCNA1_ENST00000543874.2_Intron	NM_000217.2	NP_000208.2	Q09470	KCNA1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	225					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			NS(1)|breast(3)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(23)|ovary(3)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CTTCATCGTGGAAACGCTGTG	0.512000													42	14					0	0	0.847076	0	0
GOLGA6L2	283685	broad.mit.edu	37	15	23692317	23692317	+	Silent	SNP	T	T	C			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr15:23692317T>C	ENST00000567107.1	-	1	64	c.12A>G	c.(10-12)caA>caG	p.Q4Q	GOLGA6L2_ENST00000312015.5_Silent_p.Q4Q|GOLGA6L2_ENST00000345070.5_5'UTR					golgin A6 family-like 2											breast(1)|endometrium(7)	8						GGAGGTGGGGTTGGGGCCACA	0.547000													12	39					0	0	0.520397	0	0
SPEF1	25876	broad.mit.edu	37	20	3759160	3759160	+	Missense_Mutation	SNP	C	C	T			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr20:3759160C>T	ENST00000379756.3	-	6	671	c.511G>A	c.(511-513)Gcg>Acg	p.A171T	SPEF1_ENST00000463490.1_5'UTR	NM_015417.4	NP_056232.2	Q9Y4P9	SPEF1_HUMAN	sperm flagellar 1	171						cilium axoneme|cytoplasm|cytoskeleton				cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	8						CGGTTATACGCTGGAGGCCGA	0.672000													10	5					0	0	0.387290	0	0
LINC01250	101927554	broad.mit.edu	37	2	2910378	2910379	+	RNA	INS	-	-	C	rs72051156	by1000genomes	TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr2:2910378_2910379insC	ENST00000457478.1	-	0	594																											ACAGCCGCCCACCCTACACCTT	0.639													2	4	---	---	---	---					
LINC01250	101927554	broad.mit.edu	37	2	3061736	3061738	+	RNA	DEL	TGG	TGG	-			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr2:3061736_3061738delTGG	ENST00000457478.1	-	0	438																											gcaaagatgatggtggtggtggt	0.493													2	4	---	---	---	---					
ASXL2	55252	broad.mit.edu	37	2	26022304	26022306	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr2:26022304_26022306delCTG	ENST00000435504.4	-	5	644_646	c.351_353delCAG	c.(349-354)agt>ag	p.SS117del	ASXL2_ENST00000497092.1_5'UTR|ASXL2_ENST00000336112.4_In_Frame_Del_p.SS89del|ASXL2_ENST00000272341.4_5'UTR			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	117	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCACCATCACTGCTGCTGCTGC	0.463													7	221	---	---	---	---					
AC073321.4	0	broad.mit.edu	37	2	217475032	217475032	+	RNA	DEL	A	A	-	rs71401156		TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr2:217475032delA	ENST00000441803.1	+	0	195																											ATTTTATTTCAAAAAAAAAAA	0.373													3	4	---	---	---	---					
CEP290	80184	broad.mit.edu	37	12	88512305	88512305	+	Frame_Shift_Del	DEL	T	T	-	rs77980773		TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr12:88512305delT	ENST00000552810.1	-	17	2009	c.1666delA	c.(1666-1668)ttfs	p.I556fs	CEP290_ENST00000309041.7_Frame_Shift_Del_p.I558fs|CEP290_ENST00000397838.3_5'UTR	NM_025114.3	NP_079390.3	O15078	CE290_HUMAN	centrosomal protein 290kDa	556					cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding	p.I558fs*20(1)		breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|liver(1)|lung(18)|ovary(5)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	73						ATTTGACGAATTTTTTTTTTC	0.308													2	4	---	---	---	---					
ZNF382	84911	broad.mit.edu	37	19	37117823	37117823	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr19:37117823delC	ENST00000435416.1	+	3	2516	c.1021delC	c.(1021-1023)atfs	p.H341fs	ZNF382_ENST00000292928.2_Frame_Shift_Del_p.H342fs|ZNF382_ENST00000423582.1_Frame_Shift_Del_p.H293fs|ZNF382_ENST00000439428.1_Frame_Shift_Del_p.H341fs			Q96SR6	ZN382_HUMAN	zinc finger protein 382	342	Required for transcriptional repression activity; probably mediates sequence- specific DNA-binding (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	34	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			CCTCACCCTTCATGAGAAAAC	0.448													95	46	---	---	---	---					
CTCFL	140690	broad.mit.edu	37	20	56099187	56099187	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr20:56099187delT	ENST00000426658.2	-	1	736	c.75delA	c.(73-75)aafs	p.K25fs	CTCFL_ENST00000433949.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000423479.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000422869.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000422109.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000371196.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000539382.1_Intron|CTCFL_ENST00000502686.2_Intron|CTCFL_ENST00000243914.3_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000432255.2_Frame_Shift_Del_p.K25fs|CTCFL_ENST00000429804.2_Frame_Shift_Del_p.K25fs			Q8NI51	CTCFL_HUMAN	CCCTC-binding factor (zinc finger protein)-like	25					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(28)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			CCTTCAGGCCTTTTTCCGGCA	0.502													7	722	---	---	---	---					
RP1-288L1.4	0	broad.mit.edu	37	22	35111765	35111766	+	RNA	INS	-	-	TCC	rs141084398	by1000genomes	TCGA-BF-A3DN-01A-11D-A20D-08	TCGA-BF-A3DN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	32441c2f-4c8e-45de-b036-06334326c86e	c7e56ac3-77aa-41c3-8e87-df6582f27643	g.chr22:35111765_35111766insTCC	ENST00000440858.1	-	0	64																											cctctttctcttcctcctcctc	0.554													2	4	---	---	---	---					
