Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RGPD3	653489	broad.mit.edu	37	2	107029712	107029712	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr2:107029712T>A	ENST00000409886.3	-	22	5181	c.5094A>T	c.(5092-5094)gaA>gaT	p.E1698D	RGPD3_ENST00000304514.7_Missense_Mutation_p.E1698D	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1698					intracellular transport		binding			breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						CTTGATTCCTTTCCAATCTTC	0.408000													74	23					0	0	1	0	0
SLC5A9	200010	broad.mit.edu	37	1	48699391	48699391	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:48699391C>T	ENST00000236495.5	+	10	1223	c.1173C>T	c.(1171-1173)tcC>tcT	p.S391S	SLC5A9_ENST00000533824.1_Silent_p.S387S|SLC5A9_ENST00000438567.2_Silent_p.S366S|SLC5A9_ENST00000420136.2_3'UTR	NM_001135181.1	NP_001128653.1	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 9	366						integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			breast(1)|endometrium(3)|large_intestine(4)|liver(2)|lung(11)|ovary(3)|prostate(1)|urinary_tract(1)	26						TGGGATGTTCCAACATTGCCT	0.567000													13	20					0	0	1	0	0
CST5	1473	broad.mit.edu	37	20	23858219	23858219	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr20:23858219A>T	ENST00000304710.4	-	2	341	c.268T>A	c.(268-270)Ttc>Atc	p.F90I		NM_001900.4	NP_001891.2	P28325	CYTD_HUMAN	cystatin D	90						extracellular region	cysteine-type endopeptidase inhibitor activity|protein binding			breast(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)|stomach(1)	11						GTTCGACCGAACTTCACATTG	0.537000													50	59					0	0	1	0	0
MAP3K9	4293	broad.mit.edu	37	14	71199977	71199977	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr14:71199977G>T	ENST00000554752.2	-	11	2108	c.2109C>A	c.(2107-2109)ttC>ttA	p.F703L	MAP3K9_ENST00000381250.4_Missense_Mutation_p.F680L|MAP3K9_ENST00000555993.2_Missense_Mutation_p.F717L|MAP3K9_ENST00000553414.1_Missense_Mutation_p.F436L|MAP3K9_ENST00000554146.1_Missense_Mutation_p.F431L			P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	703					activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		CTCCACGAGGGAATGGGATAC	0.587000													20	40					2.54575e-18	2.59219e-18	1	1	0
DMGDH	29958	broad.mit.edu	37	5	78320152	78320152	+	Splice_Site	SNP	A	A	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:78320152A>G	ENST00000255189.3	-	14	2220	c.2190_splice	c.e14-1	p.M731_splice	DMGDH_ENST00000380311.4_Splice_Site_p.M530_splice|DMGDH_ENST00000540686.1_Splice_Site_p.M351_splice	NM_013391.2	NP_037523.2	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase	731					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	34		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		ATCACAGTTCATCTAAAAAGG	0.308000													16	8					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3889434	3889434	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr8:3889434A>C	ENST00000520002.1	-	4	1158	c.603T>G	c.(601-603)ttT>ttG	p.F201L	CSMD1_ENST00000539096.1_Missense_Mutation_p.F201L|CSMD1_ENST00000400186.3_Missense_Mutation_p.F201L|CSMD1_ENST00000602723.1_Missense_Mutation_p.F201L|CSMD1_ENST00000602557.1_Missense_Mutation_p.F201L|CSMD1_ENST00000537824.1_Missense_Mutation_p.F201L|CSMD1_ENST00000542608.1_Missense_Mutation_p.F201L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	201	Sushi 1.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TACCTCTGCAAAAGGGAGCTG	0.527000													10	16					0	0	1	0	0
MYRF	745	broad.mit.edu	37	11	61536764	61536764	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:61536764C>T	ENST00000278836.5	+	4	527	c.431C>T	c.(430-432)tCc>tTc	p.S144F	MYRF_ENST00000265460.5_Missense_Mutation_p.S135F|TMEM258_ENST00000535042.1_Intron	NM_001127392.1	NP_001120864.1			myelin regulatory factor																		GACTCGGGCTCCGAGGCCTAC	0.677000													5	7					0	0	1	0	0
LMX1A	4009	broad.mit.edu	37	1	165173261	165173261	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:165173261G>A	ENST00000342310.3	-	9	1387	c.1005C>T	c.(1003-1005)ttC>ttT	p.F335F	LMX1A_ENST00000367893.4_Silent_p.F335F|LMX1A_ENST00000489443.2_5'UTR|LMX1A_ENST00000294816.2_Silent_p.F335F	NM_177398.3	NP_796372.1	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	335						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|central_nervous_system(3)|cervix(2)|endometrium(4)|large_intestine(6)|lung(10)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)	35	all_hematologic(923;0.248)					CCAGGTCATGGAAAAGGGGCT	0.507000													34	80					0	0	1	0	0
NINJ2	4815	broad.mit.edu	37	12	675325	675325	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:675325C>T	ENST00000305108.4	-	2	471	c.191G>A	c.(190-192)aGg>aAg	p.R64K	NINJ2_ENST00000537416.1_Intron|NINJ2_ENST00000433832.2_5'UTR|NINJ2_ENST00000397265.3_Missense_Mutation_p.R11K|NINJ2_ENST00000542920.1_5'UTR	NM_016533.4	NP_057617.2	Q9NZG7	NINJ2_HUMAN	ninjurin 2	18					nervous system development|neuron cell-cell adhesion|tissue regeneration	integral to plasma membrane				large_intestine(3)|lung(1)|ovary(2)	6	all_cancers(10;0.0101)|all_epithelial(11;0.0174)|Ovarian(42;0.0512)|all_lung(10;0.103)|Lung NSC(10;0.185)		OV - Ovarian serous cystadenocarcinoma(31;3.26e-05)|BRCA - Breast invasive adenocarcinoma(9;0.0508)			GGGCTGGCTCCTGGGGTCGGA	0.587000													16	19					0	0	1	0	0
NRG1	3084	broad.mit.edu	37	8	32463202	32463202	+	Splice_Site	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr8:32463202G>A	ENST00000341377.5	+	3	917		c.e3+1		NRG1_ENST00000287845.5_Splice_Site|NRG1_ENST00000405005.2_Splice_Site|NRG1_ENST00000287840.5_Splice_Site|NRG1_ENST00000519301.1_Splice_Site|NRG1_ENST00000338921.4_Splice_Site|NRG1_ENST00000521670.1_Splice_Site|NRG1_ENST00000287842.3_Splice_Site|NRG1_ENST00000523079.1_Splice_Site|NRG1_ENST00000356819.4_Splice_Site|NRG1_ENST00000520407.1_Splice_Site			Q02297	NRG1_HUMAN	neuregulin 1						activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(1)|skin(1)	39		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		GAATCAAACGGTAAGAGATAC	0.393000													30	55					0	0	1	0	0
PNPLA7	375775	broad.mit.edu	37	9	140409901	140409901	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr9:140409901G>A	ENST00000406427.1	-	12	1491	c.1155C>T	c.(1153-1155)tcC>tcT	p.S385S	PNPLA7_ENST00000371457.1_5'UTR|PNPLA7_ENST00000277531.4_Silent_p.S360S	NM_001098537.1	NP_001092007.1	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	360				Missing (in Ref. 1; BAC86509).	lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		GTTTGCGAATGGAAGGCGCGG	0.667000													7	2					0	0	1	0	0
OR52R1	119695	broad.mit.edu	37	11	4825016	4825016	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:4825016G>A	ENST00000380382.1	-	1	831	c.832C>T	c.(832-834)Cgt>Tgt	p.R278C	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron|OR52R1_ENST00000356069.2_Missense_Mutation_p.R199C			Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R, member 1	199					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|prostate(1)|skin(3)	29		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCATTCCCACGACTTATGCTT	0.493000													32	46					0	0	1	0	0
IGSF9B	22997	broad.mit.edu	37	11	133807296	133807296	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:133807296G>A	ENST00000321016.8	-	5	884	c.654C>T	c.(652-654)gtC>gtT	p.V218V	IGSF9B_ENST00000533871.2_Silent_p.V218V			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	218	Ig-like 2.					integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		GAGTCGTGTGGACAGCCTCCC	0.632000													6	27					0	0	1	0	0
UGT3A1	133688	broad.mit.edu	37	5	35968128	35968128	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:35968128C>T	ENST00000274278.3	-	3	661	c.304G>A	c.(304-306)Gat>Aat	p.D102N	UGT3A1_ENST00000507113.1_Missense_Mutation_p.D68N|UGT3A1_ENST00000513233.1_Intron|UGT3A1_ENST00000333811.4_Missense_Mutation_p.D48N|UGT3A1_ENST00000503189.1_Missense_Mutation_p.D102N	NM_152404.3	NP_689617.3	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	102						integral to membrane	glucuronosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|skin(4)	46	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TACCTGCCATCCAATGCTGTT	0.338000													6	19					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104049291	104049291	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:104049291T>A	ENST00000388887.2	+	15	1870	c.1666T>A	c.(1666-1668)Ttt>Att	p.F556I	RP11-341G23.2_ENST00000551905.1_RNA	NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	556	FAS1 2.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						ATACACCATTTTTGTTCCAAA	0.438000													18	45					0	0	1	0	0
PRR16	51334	broad.mit.edu	37	5	120022027	120022027	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:120022027G>A	ENST00000379551.2	+	3	826	c.469G>A	c.(469-471)Gac>Aac	p.D157N	PRR16_ENST00000505123.1_Missense_Mutation_p.D110N|PRR16_ENST00000407149.2_Missense_Mutation_p.D180N|PRR16_ENST00000446965.1_Missense_Mutation_p.D110N	NM_016644.1	NP_057728.1	Q569H4	PRR16_HUMAN	proline rich 16	180	Pro-rich.									endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	28		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		CAGTAACTTGGACAAGGCTCC	0.458000													26	13					0	0	1	0	0
LRRC36	55282	broad.mit.edu	37	16	67418797	67418797	+	Nonsense_Mutation	SNP	T	T	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:67418797T>G	ENST00000329956.6	+	14	2089	c.2070T>G	c.(2068-2070)taT>taG	p.Y690*	LRRC36_ENST00000290940.7_3'UTR|LRRC36_ENST00000435835.3_Nonsense_Mutation_p.Y465*|LRRC36_ENST00000541146.1_Nonsense_Mutation_p.Y162*|LRRC36_ENST00000563189.1_Nonsense_Mutation_p.Y569*	NM_018296.5	NP_060766.5	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36	690										endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	24		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		CTAATGAGTATCTGCTGCAGC	0.498000													27	45					0	0	1	0	0
CDX4	1046	broad.mit.edu	37	X	72667221	72667221	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chrX:72667221C>T	ENST00000373514.2	+	1	132	c.132C>T	c.(130-132)ttC>ttT	p.F44F		NM_005193.1	NP_005184.1	O14627	CDX4_HUMAN	caudal type homeobox 4	44						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(11)|skin(1)	18	Renal(35;0.156)					CCTCCAATTTCGCTGCGGCAC	0.642000													18	5					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51220062	51220062	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:51220062C>G	ENST00000293441.1	-	1	133	c.115G>C	c.(115-117)Ggg>Cgg	p.G39R	SHANK1_ENST00000391814.1_Missense_Mutation_p.G39R|SHANK1_ENST00000359082.3_Missense_Mutation_p.G39R	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	39					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		CCCCGGGTCCCCCGGGGGCCT	0.701000													15	20					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38120707	38120707	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr22:38120707C>T	ENST00000406386.3	+	7	2399	c.2144C>T	c.(2143-2145)aCc>aTc	p.T715I	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	715				RTTQQEN -> KSTFGCL (in Ref. 7; BAB33332).	actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					AACAGAACCACCCAACAAGAG	0.577000													4	111					0	0	1	0	0
PPIP5K1	9677	broad.mit.edu	37	15	43827375	43827375	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr15:43827375G>A	ENST00000420765.1	-	31	3981	c.3799C>T	c.(3799-3801)Cca>Tca	p.P1267S	PPIP5K1_ENST00000381879.4_Missense_Mutation_p.P1243S|PPIP5K1_ENST00000396923.3_Missense_Mutation_p.P1267S|PPIP5K1_ENST00000381885.1_Missense_Mutation_p.P1263S|PPIP5K1_ENST00000360301.4_Missense_Mutation_p.P1242S|PPIP5K1_ENST00000360135.4_Missense_Mutation_p.P1240S|PPIP5K1_ENST00000348806.6_Missense_Mutation_p.P1240S|PPIP5K1_ENST00000334933.4_Missense_Mutation_p.P1242S	NM_001130858.2	NP_001124330.1	Q6PFW1	VIP1_HUMAN	diphosphoinositol pentakisphosphate kinase 1	1267					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			large_intestine(1)	1						TCCTGGCATGGCTGGCTGATG	0.552000													68	114					0	0	1	0	0
TAS2R38	5726	broad.mit.edu	37	7	141673247	141673247	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:141673247G>A	ENST00000547270.1	-	1	326	c.243C>T	c.(241-243)ttC>ttT	p.F81F		NM_176817.4	NP_789787.4	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	81					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			NS(2)|breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(7)|prostate(1)|skin(1)|stomach(1)	21	Melanoma(164;0.0171)					TCAACTTCTGGAAGTGGGTAA	0.527000													51	84					0	0	1	0	0
SNTG1	54212	broad.mit.edu	37	8	51415431	51415431	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr8:51415431G>A	ENST00000522124.1	+	9	1118	c.457G>A	c.(457-459)Gat>Aat	p.D153N	SNTG1_ENST00000276467.5_Missense_Mutation_p.D153N|SNTG1_ENST00000518864.1_Missense_Mutation_p.D153N|SNTG1_ENST00000517473.1_Missense_Mutation_p.D153N	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	153					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				ATTGAATGAAGATTGTGCATG	0.323000													15	33					0	0	1	0	0
UGT1A3	54659	broad.mit.edu	37	2	234637997	234637997	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr2:234637997C>T	ENST00000482026.1	+	1	244	c.225C>T	c.(223-225)ttC>ttT	p.F75F	UGT1A10_ENST00000373445.1_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A5_ENST00000373414.3_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000480628.1_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A4_ENST00000373409.3_Intron	NM_019093.2	NP_061966.1														breast(2)|endometrium(7)|kidney(18)|large_intestine(6)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	46		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		AGAACTTTTTCACCCTGACAA	0.507000													40	69					0	0	1	0	0
ZNF852	285346	broad.mit.edu	37	3	44541670	44541670	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:44541670G>A	ENST00000436261.1	-	4	759	c.599C>T	c.(598-600)tCc>tTc	p.S200F	ZNF852_ENST00000489411.1_5'UTR			B6EU87	B6EU87_HUMAN	zinc finger protein 852	200					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|lung(5)	8						AATGAGCTGGGAGGTTTGCCT	0.488000													11	6					0	0	1	0	0
FAM193B	54540	broad.mit.edu	37	5	176951710	176951710	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:176951710G>A	ENST00000329540.5	-	9	3479	c.650C>T	c.(649-651)cCc>cTc	p.P217L	FAM193B_ENST00000514747.1_Missense_Mutation_p.P591L|FAM193B_ENST00000443375.2_Missense_Mutation_p.P558L			Q6IPW0	Q6IPW0_HUMAN	family with sequence similarity 193, member B	267										kidney(1)|large_intestine(3)	4						GGATAGGTTGGGCACGGTGTT	0.632000													5	1					0	0	1	0	0
OR6C70	390327	broad.mit.edu	37	12	55863430	55863430	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:55863430C>T	ENST00000327335.4	-	1	492	c.493G>A	c.(493-495)Gat>Aat	p.D165N	RP11-110A12.2_ENST00000555146.1_RNA|RP11-110A12.2_ENST00000554049.1_RNA|RP11-110A12.2_ENST00000556750.1_RNA|RP11-110A12.2_ENST00000555138.1_RNA	NM_001005499.1	NP_001005499.1	A6NIJ9	O6C70_HUMAN	olfactory receptor, family 6, subfamily C, member 70	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.D165N(1)		autonomic_ganglia(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	18						GCACAGAAATCCAAGTTAAGA	0.368000													23	44					0	0	1	0	0
NPHP3	27031	broad.mit.edu	37	3	132411611	132411611	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:132411611T>C	ENST00000337331.5	-	17	2448	c.2362A>G	c.(2362-2364)Atg>Gtg	p.M788V	NPHP3_ENST00000326682.8_3'UTR	NM_153240.4	NP_694972.3	Q7Z494	NPHP3_HUMAN	nephronophthisis 3 (adolescent)	788					maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(15)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TAGAGTTCCATCAGTTCTGAT	0.378000													26	45					0	0	1	0	0
NPY4R	5540	broad.mit.edu	37	10	47087023	47087023	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr10:47087023C>T	ENST00000374312.1	+	3	659	c.240C>T	c.(238-240)atC>atT	p.I80I	NPY4R_ENST00000395716.1_Silent_p.I80I	NM_005972.4	NP_005963.3			neuropeptide Y receptor Y4																		ACCTGCTTATCGCCAACCTGG	0.562000													19	129					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802855	185802855	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr2:185802855C>T	ENST00000302277.6	+	4	3326	c.2732C>T	c.(2731-2733)tCc>tTc	p.S911F		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	911						intracellular	zinc ion binding	p.S911Y(1)		NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TCAGATGTTTCCAATGATCCC	0.403000													57	21					0	0	1	0	0
ATP13A2	23400	broad.mit.edu	37	1	17316751	17316751	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:17316751G>A	ENST00000452699.1	-	21	2457	c.2268C>T	c.(2266-2268)gcC>gcT	p.A756A	RP1-37C10.3_ENST00000446261.1_RNA|ATP13A2_ENST00000341676.5_Silent_p.A756A|ATP13A2_ENST00000326735.8_Silent_p.A761A	NM_001141973.1|NM_022089.2	NP_001135445.1|NP_071372.1	Q9NQ11	AT132_HUMAN	ATPase type 13A2	761					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(11)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		CACAGCCCCGGGCCACAGTCA	0.647000													36	45					0	0	1	0	0
GGT1	2678	broad.mit.edu	37	22	25011012	25011012	+	Silent	SNP	A	A	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr22:25011012A>G	ENST00000400382.1	+	7	1055	c.300A>G	c.(298-300)aaA>aaG	p.K100K	GGT1_ENST00000248923.4_Silent_p.K100K|GGT1_ENST00000400380.1_Silent_p.K100K|GGT1_ENST00000406383.2_Silent_p.K100K|GGT1_ENST00000400383.1_Silent_p.K100K			P19440	GGT1_HUMAN	gamma-glutamyltransferase 1	100					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding			breast(1)|endometrium(2)|kidney(14)|large_intestine(2)|lung(6)|pancreas(1)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	40					Glutathione(DB00143)	TTCTAGGAAAAGCTGAGGTCA	0.637000													23	26					0	0	1	0	0
SEMA3D	223117	broad.mit.edu	37	7	84628980	84628980	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:84628980C>T	ENST00000284136.6	-	17	2153	c.2110G>A	c.(2110-2112)Gat>Aat	p.D704N	SEMA3D_ENST00000484038.1_5'UTR	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	704					cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						GCCAATAGATCCTTGACCTTC	0.473000													27	42					0	0	1	0	0
STAG3	10734	broad.mit.edu	37	7	99780444	99780444	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:99780444C>T	ENST00000426455.1	+	4	725	c.318C>T	c.(316-318)gcC>gcT	p.A106A	STAG3_ENST00000394018.2_Silent_p.A106A|STAG3_ENST00000317296.5_Silent_p.A106A			Q9UJ98	STAG3_HUMAN	stromal antigen 3	106					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(11)|lung(30)|ovary(5)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	66	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CTGTGAAAGCCGCCAAAAGTG	0.458000													5	353					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36879973	36879973	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:36879973C>T	ENST00000301807.6	-	19	5522	c.3625G>A	c.(3625-3627)Gaa>Aaa	p.E1209K	TRANK1_ENST00000429976.2_Missense_Mutation_p.E1759K|TRANK1_ENST00000428977.2_Missense_Mutation_p.E1209K	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1759					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						TTAGCCAATTCCAAATATTCC	0.458000													30	19					0	0	1	0	0
COL4A3	1285	broad.mit.edu	37	2	228153911	228153911	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr2:228153911G>A	ENST00000396578.3	+	35	3089	c.2927G>A	c.(2926-2928)gGg>gAg	p.G976E	AC097662.2_ENST00000396588.2_RNA|AC097662.2_ENST00000439598.2_RNA|AC097662.2_ENST00000433324.1_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	976	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GGCGTTCCAGGGATGCCAGGT	0.463000													21	2					0	0	1	0	0
KIAA0319	9856	broad.mit.edu	37	6	24596484	24596484	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr6:24596484C>T	ENST00000535378.1	-	4	1033	c.391G>A	c.(391-393)Gac>Aac	p.D131N	KIAA0319_ENST00000543707.1_Missense_Mutation_p.D140N|KIAA0319_ENST00000537886.1_Missense_Mutation_p.D140N|KIAA0319_ENST00000378214.3_Missense_Mutation_p.D140N|KIAA0319_ENST00000430948.2_Missense_Mutation_p.D95N	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	140					negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						AAGGTCAAGTCCTTTCTGATA	0.557000													27	61					0	0	1	0	0
CARD14	79092	broad.mit.edu	37	17	78169401	78169401	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:78169401G>C	ENST00000573882.1	+	13	2080	c.1544G>C	c.(1543-1545)gGa>gCa	p.G515A	CARD14_ENST00000344227.2_Missense_Mutation_p.G515A|CARD14_ENST00000573754.1_3'UTR|CARD14_ENST00000392434.2_Missense_Mutation_p.G278A|CARD14_ENST00000570421.1_Missense_Mutation_p.G515A			Q9BXL6	CAR14_HUMAN	caspase recruitment domain family, member 14	515					activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			NS(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(5)|prostate(1)|skin(1)	23	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			GCCCTGCCGGGAGCTAAGGCA	0.632000													19	32					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113169625	113169625	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr9:113169625G>A	ENST00000401783.2	-	38	8591	c.8255C>T	c.(8254-8256)tCt>tTt	p.S2752F	SVEP1_ENST00000297826.5_Missense_Mutation_p.S678F|SVEP1_ENST00000374469.1_Missense_Mutation_p.S2729F	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2752	Sushi 22.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CCTTAAGTCAGAGCCTGCTAG	0.463000													20	17					0	0	1	0	0
ARG1	383	broad.mit.edu	37	6	131894455	131894455	+	Silent	SNP	T	T	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr6:131894455T>A	ENST00000368087.3	+	1	172	c.33T>A	c.(31-33)atT>atA	p.I11I	ARG1_ENST00000476845.1_Silent_p.I11I|ARG1_ENST00000356962.2_Silent_p.I11I|ARG1_ENST00000498260.1_3'UTR			P05089	ARGI1_HUMAN	arginase 1	11			I -> T (in ARGIN; 12% of wild-type activity; dbSNP:rs28941474).		arginine catabolic process|urea cycle	cytosol	arginase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(1)|skin(3)	14	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0106)|OV - Ovarian serous cystadenocarcinoma(155;0.0713)	L-Ornithine(DB00129)	TAGGGATTATTGGAGCTCCTT	0.428000													28	24					0	0	1	0	0
TBL2	26608	broad.mit.edu	37	7	72985290	72985290	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:72985290G>A	ENST00000305632.5	-	7	1132	c.891C>T	c.(889-891)gtC>gtT	p.V297V	TBL2_ENST00000459913.1_5'UTR|TBL2_ENST00000432538.1_Silent_p.V261V	NM_012453.2	NP_036585.1	Q9Y4P3	TBL2_HUMAN	transducin (beta)-like 2	297										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	19		Lung NSC(55;0.0659)|all_lung(88;0.152)				CATCCTTGGAGACAGAAGCCA	0.542000													29	57					0	0	1	0	0
FRMD6	122786	broad.mit.edu	37	14	52182062	52182062	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr14:52182062T>C	ENST00000395718.2	+	10	1130	c.845T>C	c.(844-846)tTg>tCg	p.L282S	FRMD6_ENST00000356218.4_Missense_Mutation_p.L282S|FRMD6_ENST00000344768.5_Missense_Mutation_p.L290S|FRMD6_ENST00000554167.1_Missense_Mutation_p.L213S	NM_001267046.1|NM_152330.3	NP_001253975.1|NP_689543.1	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	290	FERM.					cytoskeleton|mitochondrion|plasma membrane	binding			breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(7)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_epithelial(31;0.0163)|Breast(41;0.089)					TTTGAGATTTTGCCAGATGGC	0.473000													30	44					0	0	1	0	0
NDUFV3	4731	broad.mit.edu	37	21	44324272	44324272	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr21:44324272C>T	ENST00000354250.2	+	3	1219	c.1150C>T	c.(1150-1152)Cct>Tct	p.P384S	NDUFV3_ENST00000460259.1_3'UTR|NDUFV3_ENST00000340344.3_Intron	NM_021075.3	NP_066553.3	P56181	NDUV3_HUMAN	NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa	0					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I|nucleus	NADH dehydrogenase (ubiquinone) activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	10				STAD - Stomach adenocarcinoma(101;0.0606)	NADH(DB00157)	GGAGACAGTTCCTGTTGAGAA	0.557000													16	21					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31302335	31302335	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:31302335G>A	ENST00000265071.2	+	6	1194	c.929G>A	c.(928-930)gGt>gAt	p.G310D	CDH6_ENST00000514738.1_Missense_Mutation_p.G255D	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	310	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						ATCACAGACGGTGAGGGGCTG	0.478000													20	41					0	0	1	0	0
FPR1	2357	broad.mit.edu	37	19	52249630	52249630	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:52249630G>A	ENST00000595042.1	-	3	759	c.618C>T	c.(616-618)ttC>ttT	p.F206F	FPR1_ENST00000304748.4_Silent_p.F206F	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	206					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	AGCCAATGATGAACCGGATGA	0.507000													40	56					0	0	1	0	0
BUB3	9184	broad.mit.edu	37	10	124917345	124917345	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr10:124917345G>A	ENST00000368865.4	+	4	575	c.366G>A	c.(364-366)ctG>ctA	p.L122L	BUB3_ENST00000368858.5_Silent_p.L122L|BUB3_ENST00000368859.2_Silent_p.L122L|BUB3_ENST00000538238.1_Silent_p.L42L	NM_004725.3	NP_004716.1	O43684	BUB3_HUMAN	BUB3 mitotic checkpoint protein	122					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|attachment of spindle microtubules to kinetochore|cell division|meiosis|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	condensed chromosome kinetochore|cytosol|nucleus	protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	9		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)				CAGTTAAACTGTGGGATCCCA	0.443000													15	33					0	0	1	0	0
OLR1	4973	broad.mit.edu	37	12	10321753	10321753	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:10321753G>A	ENST00000309539.3	-	2	158	c.98C>T	c.(97-99)cCa>cTa	p.P33L	OLR1_ENST00000432556.2_Missense_Mutation_p.P33L|OLR1_ENST00000545927.1_Missense_Mutation_p.P33L|OLR1_ENST00000544577.1_Missense_Mutation_p.P33L	NM_002543.3	NP_002534.1	P78380	OLR1_HUMAN	oxidized low density lipoprotein (lectin-like) receptor 1	33					blood circulation|blood coagulation|inflammatory response|leukocyte migration|proteolysis	extracellular region|integral to plasma membrane|membrane fraction	sugar binding			breast(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|skin(1)	10						GCACCACCATGGAGAGTAAAG	0.458000													14	32					0	0	1	0	0
ARPP21	10777	broad.mit.edu	37	3	35763134	35763134	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:35763134C>T	ENST00000187397.4	+	14	1489	c.1033C>T	c.(1033-1035)Cga>Tga	p.R345*	ARPP21_ENST00000337271.5_Nonsense_Mutation_p.R291*|ARPP21_ENST00000458225.1_Nonsense_Mutation_p.R311*|ARPP21_ENST00000444190.1_Nonsense_Mutation_p.R291*|ARPP21_ENST00000417925.1_Nonsense_Mutation_p.R311*	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	345	Ser-rich.					cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						ATCTGGGAGTCGACAGAGCAG	0.532000													9	11					0	0	1	0	0
ZHX2	22882	broad.mit.edu	37	8	123964128	123964128	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr8:123964128C>T	ENST00000314393.4	+	3	1213	c.378C>T	c.(376-378)tcC>tcT	p.S126S		NM_014943.3	NP_055758.1	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	126						cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	45	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			ACTCCCTATCCGACCACAACT	0.478000													43	55					0	0	1	0	0
MYO18A	399687	broad.mit.edu	37	17	27437561	27437561	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:27437561C>T	ENST00000527372.1	-	18	3160	c.2980G>A	c.(2980-2982)Ggc>Agc	p.G994S	MYO18A_ENST00000354329.4_Missense_Mutation_p.G994S|MYO18A_ENST00000533112.1_Missense_Mutation_p.G994S|MYO18A_ENST00000531253.1_Missense_Mutation_p.G994S	NM_078471.3	NP_510880.2	Q92614	MY18A_HUMAN	myosin XVIIIA	994	Myosin head-like.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity			NS(1)|cervix(1)|endometrium(6)|kidney(6)|lung(20)|urinary_tract(2)	36			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			AGCTGCGAGCCGCCCTCCAGG	0.602000													9	15					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55493908	55493908	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:55493908G>A	ENST00000543010.1	+	6	985	c.842G>A	c.(841-843)cGg>cAg	p.R281Q	NLRP2_ENST00000263437.6_Missense_Mutation_p.R278Q|NLRP2_ENST00000339757.7_Missense_Mutation_p.R259Q|NLRP2_ENST00000391721.4_Missense_Mutation_p.R257Q|NLRP2_ENST00000427260.2_Missense_Mutation_p.R258Q|NLRP2_ENST00000538819.1_Missense_Mutation_p.R257Q|NLRP2_ENST00000537859.1_Missense_Mutation_p.R259Q|NLRP2_ENST00000448584.2_Missense_Mutation_p.R281Q	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	281	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GCCCAAGCACGGAAAATCTTG	0.587000													25	46					0	0	1	0	0
NEIL2	252969	broad.mit.edu	37	8	11628989	11628989	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr8:11628989C>T	ENST00000284503.6	+	2	632	c.33C>T	c.(31-33)caC>caT	p.H11H	NEIL2_ENST00000436750.3_Silent_p.H11H|NEIL2_ENST00000455213.2_Silent_p.H11H|NEIL2_ENST00000528323.1_Silent_p.H11H|NEIL2_ENST00000403422.3_Intron	NM_145043.2	NP_659480.1	Q969S2	NEIL2_HUMAN	nei endonuclease VIII-like 2 (E. coli)	11					base-excision repair|nucleotide-excision repair	nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|hydrolase activity, hydrolyzing N-glycosyl compounds|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	10	all_epithelial(15;0.103)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.166)		GGAAATTTCACCATTTGGTCT	0.547000								Base excision repair (BER), DNA glycosylases					48	49					0	0	1	0	0
PRKCB	5579	broad.mit.edu	37	16	24166021	24166021	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:24166021G>A	ENST00000303531.7	+	10	1234	c.1082G>A	c.(1081-1083)cGa>cAa	p.R361Q	PRKCB_ENST00000321728.7_Missense_Mutation_p.R361Q	NM_002738.6	NP_002729.2	P05771	KPCB_HUMAN	protein kinase C, beta	361	Protein kinase.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			central_nervous_system(3)|large_intestine(1)|lung(2)|ovary(3)	9					Vitamin E(DB00163)	CTTTCAGAACGAAAAGGCACA	0.507000													16	37					0	0	1	0	0
MMS22L	253714	broad.mit.edu	37	6	97717824	97717824	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr6:97717824T>C	ENST00000275053.4	-	7	916	c.651A>G	c.(649-651)atA>atG	p.I217M	MMS22L_ENST00000369251.2_Missense_Mutation_p.I217M|MMS22L_ENST00000506256.1_5'UTR	NM_198468.2	NP_940870.2	Q6ZRQ5	MMS22_HUMAN	MMS22-like, DNA repair protein	217					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding			breast(1)|endometrium(9)|kidney(2)|large_intestine(12)|lung(20)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	50						CCAGCCAATGTATATCCAAGT	0.308000													30	16					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	55989073	55989073	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr6:55989073C>T	ENST00000244728.5	-	15	2065	c.1668G>A	c.(1666-1668)aaG>aaA	p.K556K	COL21A1_ENST00000370819.1_Silent_p.K553K|COL21A1_ENST00000535941.1_Silent_p.K556K	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	556	Collagen-like 2.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			CAGCATTCCCCTTTTCACCTT	0.353000													6	10					0	0	1	0	0
SOBP	55084	broad.mit.edu	37	6	107955843	107955843	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr6:107955843C>T	ENST00000317357.5	+	6	2454	c.1795C>T	c.(1795-1797)Ccc>Tcc	p.P599S		NM_018013.3	NP_060483.3	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog (Drosophila)	599							metal ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	26		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		GGACTCGCCCCCCGGCTGCTC	0.791000													5	2					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10541359	10541359	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:10541359C>T	ENST00000583535.1	-	27	3817		c.e27+1		MYH3_ENST00000226209.7_Splice_Site	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic						muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						CCGCGCAGCACCTTAGATTTC	0.547000													41	83					0	0	1	0	0
CSNK2A1	1457	broad.mit.edu	37	20	470440	470440	+	Missense_Mutation	SNP	T	T	C	rs61730060		TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr20:470440T>C	ENST00000217244.3	-	10	1082	c.707A>G	c.(706-708)cAt>cGt	p.H236R	CSNK2A1_ENST00000349736.5_Missense_Mutation_p.H236R|CSNK2A1_ENST00000460062.1_5'UTR|CSNK2A1_ENST00000400217.1_Missense_Mutation_p.H100R|CSNK2A1_ENST00000400227.3_Missense_Mutation_p.H236R	NM_177559.2	NP_808227.1	P68400	CSK21_HUMAN	casein kinase 2, alpha 1 polypeptide	236	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|NuRD complex|plasma membrane|Sin3 complex	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity	p.H236R(2)		autonomic_ganglia(1)|central_nervous_system(2)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|urinary_tract(1)	17		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)			ATAATTGTCATGTCCATGGAA	0.373000													3	51					0	0	1	0	0
SERPINA4	5267	broad.mit.edu	37	14	95030336	95030336	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr14:95030336T>C	ENST00000557004.1	+	2	938	c.517T>C	c.(517-519)Tac>Cac	p.Y173H	SERPINA4_ENST00000298841.5_Missense_Mutation_p.Y173H|SERPINA4_ENST00000555095.1_Missense_Mutation_p.Y173H|SERPINA5_ENST00000553780.1_Intron			P29622	KAIN_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4	173					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(28)|ovary(3)|skin(1)|urinary_tract(1)	46				COAD - Colon adenocarcinoma(157;0.211)		CACCAACTTCTACGACACTGT	0.493000													65	107					0	0	1	0	0
MYO3B	140469	broad.mit.edu	37	2	171358320	171358320	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr2:171358320G>A	ENST00000334231.6	+	28	3342	c.3342G>A	c.(3340-3342)agG>agA	p.R1114R	MYO3B_ENST00000409044.3_Intron|MYO3B_ENST00000602629.1_Intron|MYO3B_ENST00000408978.4_Silent_p.R1105R			Q8WXR4	MYO3B_HUMAN	myosin IIIB	1105	IQ 2.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						ATGCTCGGAGGAAATTTAAGA	0.348000													28	4					0	0	1	0	0
TAF3	83860	broad.mit.edu	37	10	8006790	8006790	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr10:8006790C>T	ENST00000344293.5	+	3	1523	c.1317C>T	c.(1315-1317)tcC>tcT	p.S439S		NM_031923.3	NP_114129.1	Q5VWG9	TAF3_HUMAN	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa	439					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			NS(2)|breast(4)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(3)|prostate(4)|skin(2)	40						CTTCCACTTCCGCGAACAATT	0.468000													37	76					0	0	1	0	0
STRIP2	57464	broad.mit.edu	37	7	129091563	129091563	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:129091563C>T	ENST00000249344.2	+	4	424	c.384C>T	c.(382-384)gcC>gcT	p.A128A	STRIP2_ENST00000435494.2_Silent_p.A128A	NM_020704.2	NP_065755.1			striatin interacting protein 2																		TGAAGGTGGCCCGGGCTGTTC	0.557000													16	36					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13717491	13717491	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:13717491T>G	ENST00000265104.4	-	73	12742	c.12638A>C	c.(12637-12639)aAc>aCc	p.N4213T		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4213	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GTCCGCTTGGTTAAATTCGTA	0.532000									Kartagener syndrome				20	22					0	0	1	0	0
LINGO4	339398	broad.mit.edu	37	1	151774481	151774481	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:151774481C>T	ENST00000368820.3	-	2	1637	c.700G>A	c.(700-702)Gag>Aag	p.E234K		NM_001004432.2	NP_001004432.1	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	234						integral to membrane				breast(2)|cervix(1)|endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			AGGTGGATCTCCAGCTCCTTG	0.637000													41	70					0	0	1	0	0
C20orf194	25943	broad.mit.edu	37	20	3274837	3274837	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr20:3274837A>C	ENST00000252032.9	-	25	2253	c.2186T>G	c.(2185-2187)gTg>gGg	p.V729G	C20orf194_ENST00000453730.2_Missense_Mutation_p.V467G	NM_001009984.2	NP_001009984.1	Q5TEA3	CT194_HUMAN	chromosome 20 open reading frame 194	729										NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	39						CTGCAGCAGCACAGGAAGATG	0.453000													19	33					0	0	1	0	0
DCSTAMP	81501	broad.mit.edu	37	8	105361507	105361507	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr8:105361507G>A	ENST00000297581.2	+	2	776	c.727G>A	c.(727-729)Gaa>Aaa	p.E243K	DPYS_ENST00000521601.1_Intron|DCSTAMP_ENST00000517991.1_Missense_Mutation_p.E243K	NM_030788.3	NP_110415.1	Q9H295	TM7S4_HUMAN	dendrocyte expressed seven transmembrane protein	243					osteoclast differentiation	cell surface|integral to membrane|plasma membrane											TTGGAAGTATGAAAACATCTA	0.498000													45	56					0	0	1	0	0
BDP1	55814	broad.mit.edu	37	5	70845308	70845308	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:70845308G>A	ENST00000358731.4	+	34	7133	c.6870G>A	c.(6868-6870)ctG>ctA	p.L2290L	BDP1_ENST00000380675.2_Intron	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	2290					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		TTTTAACTCTGGTGGAAATCC	0.383000													19	10					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89348949	89348949	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:89348949G>A	ENST00000301030.4	-	9	4461	c.4001C>T	c.(4000-4002)cCg>cTg	p.P1334L	ANKRD11_ENST00000378330.2_Missense_Mutation_p.P1334L	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1334	Lys-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GCTCTCCCTCGGCTTGTCGTC	0.612000													28	40					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124350191	124350191	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr10:124350191C>T	ENST00000338354.3	+	18	2224	c.2118C>T	c.(2116-2118)tcC>tcT	p.S706S	DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000344338.3_Silent_p.S696S|DMBT1_ENST00000368956.2_Intron|DMBT1_ENST00000368955.3_Silent_p.S696S|DMBT1_ENST00000330163.4_Intron|DMBT1_ENST00000368909.3_Silent_p.S706S			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	706					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CTGCCCAGTCCCGGTCGACGC	0.517000													125	223					0	0	1	0	0
HOGA1	112817	broad.mit.edu	37	10	99359853	99359853	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr10:99359853G>A	ENST00000370646.4	+	5	994	c.633G>A	c.(631-633)aaG>aaA	p.K211K	HOGA1_ENST00000370647.4_Intron|PI4K2A_ENST00000370649.3_Intron|PI4K2A_ENST00000555577.1_Intron	NM_138413.3	NP_612422.2			4-hydroxy-2-oxoglutarate aldolase 1											breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|prostate(2)|skin(1)|stomach(1)	14						TTGTTCACAAGACCAGGAAGC	0.557000													97	170					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228444456	228444456	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:228444456G>A	ENST00000570156.2	+	16	4764	c.4690G>A	c.(4690-4692)Gag>Aag	p.E1564K	OBSCN_ENST00000359599.6_Missense_Mutation_p.E36K|OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000284548.11_Missense_Mutation_p.E1472K|OBSCN_ENST00000422127.1_Missense_Mutation_p.E1472K	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	545	Ig-like 16.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GGCCCAGACGGAGGTGATGTG	0.652000													45	57					0	0	1	0	0
SLC7A9	11136	broad.mit.edu	37	19	33324149	33324149	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:33324149C>T	ENST00000023064.4	-	12	1496	c.1305G>A	c.(1303-1305)tgG>tgA	p.W435*	SLC7A9_ENST00000587772.1_Nonsense_Mutation_p.W435*|SLC7A9_ENST00000590341.1_Nonsense_Mutation_p.W435*	NM_001126335.1|NM_001243036.1|NM_014270.4	NP_001119807.1|NP_001229965.1|NP_055085.1	P82251	BAT1_HUMAN	solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9	435					blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	32	Esophageal squamous(110;0.137)				L-Cystine(DB00138)	AGAGGTACTCCCAGGTGGGCT	0.453000													21	60					0	0	1	0	0
OR51T1	401665	broad.mit.edu	37	11	4903652	4903652	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:4903652G>A	ENST00000380378.1	+	1	604	c.604G>A	c.(604-606)Gag>Aag	p.E202K	OR51T1_ENST00000322049.1_Missense_Mutation_p.E175K|MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004759.1	NP_001004759.1	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T, member 1	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGGGGTCACGAGCTTTCCCA	0.458000													60	80					0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	35969446	35969446	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chrX:35969446C>T	ENST00000297866.5	+	5	921	c.855C>T	c.(853-855)atC>atT	p.I285I		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	285										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						GGGTGGCCATCATACAAGATG	0.373000													20	2					0	0	1	0	0
KIF13A	63971	broad.mit.edu	37	6	17779315	17779315	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr6:17779315C>T	ENST00000378814.5	-	32	3915	c.3916G>A	c.(3916-3918)Gag>Aag	p.E1306K	KIF13A_ENST00000259711.6_Missense_Mutation_p.E1319K|KIF13A_ENST00000378843.2_Missense_Mutation_p.E1306K|KIF13A_ENST00000378816.5_Missense_Mutation_p.E1319K|KIF13A_ENST00000378826.2_Missense_Mutation_p.E1319K	NM_001105568.2	NP_001099038.1	Q9H1H9	KI13A_HUMAN	kinesin family member 13A	1319					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TCCCGGTCCTCTATCTCCTCA	0.488000													16	21					0	0	1	0	0
EXD1	161829	broad.mit.edu	37	15	41508898	41508898	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr15:41508898G>A	ENST00000314992.5	-	3	372	c.182C>T	c.(181-183)tCt>tTt	p.S61F	EXD1_ENST00000458580.2_Missense_Mutation_p.S119F	NM_152596.2	NP_689809.2	Q8NHP7	EXD1_HUMAN	exonuclease 3'-5' domain containing 1	61	3'-5' exonuclease.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			large_intestine(5)|liver(1)|lung(4)|ovary(2)|prostate(2)|skin(2)	16						ATTCAGCAGAGAGGTAGCTGG	0.453000													21	30					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169176903	169176903	+	Silent	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr4:169176903T>C	ENST00000393743.3	-	26	3807	c.3516A>G	c.(3514-3516)aaA>aaG	p.K1172K	DDX60_ENST00000505393.1_5'UTR	NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	1172							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		CTTTTCGAAGTTTGTTAGCCA	0.368000													8	16					0	0	1	0	0
ELOVL1	64834	broad.mit.edu	37	1	43830936	43830936	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:43830936C>T	ENST00000372458.3	-	3	275	c.158G>A	c.(157-159)cGg>cAg	p.R53Q	ELOVL1_ENST00000470769.1_5'UTR|ELOVL1_ENST00000413844.2_Missense_Mutation_p.R53Q	NM_001256399.1|NM_001256402.1|NM_022821.3	NP_001243328.1|NP_001243331.1|NP_073732.1	Q9BW60	ELOV1_HUMAN	ELOVL fatty acid elongase 1	53					fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|sphingolipid biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	fatty acid elongase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|prostate(1)	4	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GAAGGGCTTCCGATTAGCCAT	0.562000													12	19					0	0	1	0	0
OR4C15	81309	broad.mit.edu	37	11	55322161	55322161	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:55322161T>C	ENST00000314644.2	+	1	379	c.379T>C	c.(379-381)Tca>Cca	p.S127P		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	73					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						TGCGTGCTTCTCATCTGTCAT	0.458000										HNSCC(20;0.049)			9	164					0	0	1	0	0
SIX4	51804	broad.mit.edu	37	14	61190639	61190639	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr14:61190639G>A	ENST00000216513.4	-	1	213	c.154C>T	c.(154-156)Ccc>Tcc	p.P52S		NM_017420.4	NP_059116.3	Q9UIU6	SIX4_HUMAN	SIX homeobox 4	52	Ala-rich.					nucleus				breast(5)|endometrium(1)|large_intestine(11)|liver(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28				OV - Ovarian serous cystadenocarcinoma(108;0.0275)		GGCTCCAGGGGAAAAGGGGCT	0.746000													23	23					0	0	1	0	0
ALB	213	broad.mit.edu	37	4	74270081	74270081	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr4:74270081T>A	ENST00000295897.4	+	1	126	c.37T>A	c.(37-39)Ttt>Att	p.F13I	ALB_ENST00000503124.1_5'UTR|ALB_ENST00000509063.1_Missense_Mutation_p.F13I|ALB_ENST00000415165.2_Missense_Mutation_p.F13I|ALB_ENST00000401494.3_Missense_Mutation_p.F13I	NM_000477.5	NP_000468.1	P02768	ALBU_HUMAN	albumin	13					bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(6)|liver(9)|lung(16)|ovary(3)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	48	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin iodonated(DB00064)|Serum albumin(DB00096)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	TCTTTTTCTCTTTAGCTCGGC	0.403000													16	36					0	0	1	0	0
AHCYL2	23382	broad.mit.edu	37	7	129028959	129028959	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:129028959T>A	ENST00000325006.3	+	3	592	c.538T>A	c.(538-540)Tct>Act	p.S180T	AHCYL2_ENST00000472554.1_3'UTR|AHCYL2_ENST00000446544.2_Missense_Mutation_p.S179T|AHCYL2_ENST00000474594.1_Missense_Mutation_p.S77T|AHCYL2_ENST00000531335.2_Missense_Mutation_p.S99T|AHCYL2_ENST00000446212.1_Missense_Mutation_p.S78T|AHCYL2_ENST00000490911.1_Missense_Mutation_p.S77T	NM_001130720.2|NM_015328.3	NP_001124192.1|NP_056143.1	Q96HN2	SAHH3_HUMAN	adenosylhomocysteinase-like 2	180					one-carbon metabolic process		adenosylhomocysteinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	22						GCAAAAGAACTCTAAGGGAAG	0.403000													23	44					0	0	1	0	0
CCM2	83605	broad.mit.edu	37	7	45108124	45108124	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:45108124T>G	ENST00000475551.1	+	5	1297	c.537T>G	c.(535-537)agT>agG	p.S179R	CCM2_ENST00000461377.1_3'UTR|CCM2_ENST00000381112.3_Missense_Mutation_p.S206R|CCM2_ENST00000474617.1_Intron|CCM2_ENST00000541586.1_Missense_Mutation_p.S127R|CCM2_ENST00000544363.1_Intron|CCM2_ENST00000258781.6_Missense_Mutation_p.S185R			Q9BSQ5	CCM2_HUMAN	cerebral cavernous malformation 2	185	PID.				endothelial tube morphogenesis|integrin-mediated signaling pathway|stress-activated MAPK cascade|vasculogenesis	cytoplasm	protein binding			NS(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19						TGTCGGAGAGTGCAGTTGGGC	0.607000													28	45					0	0	1	0	0
CASZ1	54897	broad.mit.edu	37	1	10720283	10720283	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:10720283G>A	ENST00000377022.3	-	6	1133	c.816C>T	c.(814-816)acC>acT	p.T272T	CASZ1_ENST00000344008.5_Silent_p.T272T	NM_001079843.1	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	272					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		GGCCGGGCAGGGTGCCCACCA	0.687000													29	42					0	0	1	0	0
PIAS1	8554	broad.mit.edu	37	15	68446018	68446018	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr15:68446018C>T	ENST00000545237.1	+	8	1666	c.925C>T	c.(925-927)Cat>Tat	p.H309Y	PIAS1_ENST00000249636.6_Missense_Mutation_p.H307Y			O75925	PIAS1_HUMAN	protein inhibitor of activated STAT, 1	307					androgen receptor signaling pathway|interferon-gamma-mediated signaling pathway|JAK-STAT cascade|positive regulation of protein sumoylation|positive regulation of transcription, DNA-dependent|regulation of interferon-gamma-mediated signaling pathway|transcription, DNA-dependent	nuclear speck	androgen receptor binding|DNA binding|enzyme binding|SUMO ligase activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)	24						GAATCCGGATCATTCTAGAGC	0.328000													12	15					0	0	1	0	0
NCOA7	135112	broad.mit.edu	37	6	126199464	126199464	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr6:126199464A>G	ENST00000368357.3	+	6	759	c.407A>G	c.(406-408)aAt>aGt	p.N136S	NCOA7_ENST00000392477.2_Missense_Mutation_p.N136S|NCOA7_ENST00000229634.9_Missense_Mutation_p.N32S	NM_001199619.1|NM_001199620.1	NP_001186548.1|NP_001186549.1	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7	136					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(6)|lung(16)|ovary(1)|skin(1)|soft_tissue(1)|urinary_tract(2)	39				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		ATCACTCCCAATAAATTGGTG	0.338000													15	8					0	0	1	0	0
FAM114A2	10827	broad.mit.edu	37	5	153406841	153406841	+	Silent	SNP	G	G	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:153406841G>T	ENST00000351797.4	-	7	760	c.684C>A	c.(682-684)acC>acA	p.T228T	FAM114A2_ENST00000522858.1_Silent_p.T228T|FAM114A2_ENST00000520313.1_Silent_p.T158T|FAM114A2_ENST00000520667.1_Silent_p.T228T	NM_018691.2	NP_061161.2	Q9NRY5	F1142_HUMAN	family with sequence similarity 114, member A2	228							purine nucleotide binding			NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|skin(1)|urinary_tract(1)	18						CTGTTTCCACGGTAACCTCAT	0.423000													18	6					3.32936e-07	3.36221e-07	1	1	0
ZNF700	90592	broad.mit.edu	37	19	12060313	12060313	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:12060313C>T	ENST00000482090.1	+	3	1838	c.1420C>T	c.(1420-1422)Cat>Tat	p.H474Y	ZNF763_ENST00000538752.1_Intron|ZNF763_ENST00000591944.1_Intron|ZNF763_ENST00000590798.1_Intron|ZNF700_ENST00000254321.5_Missense_Mutation_p.H492Y|CTD-2006C1.12_ENST00000586394.1_RNA			Q9H0M5	ZN700_HUMAN	zinc finger protein 700	492					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		ZNF700/MAST1_ENST00000251472(2)	breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(13)|pancreas(1)|prostate(1)|urinary_tract(1)	33						CCTTCAAATTCATGAAAGGAC	0.398000													27	48					0	0	1	0	0
SLC22A9	114571	broad.mit.edu	37	11	63137759	63137759	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:63137759C>T	ENST00000279178.3	+	1	480	c.231C>T	c.(229-231)atC>atT	p.I77I	SLC22A9_ENST00000310969.4_Silent_p.I77I	NM_080866.2	NP_543142.2	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion transporter), member 9	77					transmembrane transport	integral to membrane				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	18						GAATCTCCATCCCACTGGACT	0.542000													36	65					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124332540	124332540	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:124332540C>T	ENST00000409039.3	+	32	5518	c.5493C>T	c.(5491-5493)gcC>gcT	p.A1831A		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1831	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GGGCCCCCGCCGGCCCAGCAG	0.532000													52	117					0	0	1	0	0
GRIK3	2899	broad.mit.edu	37	1	37356552	37356552	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:37356552G>A	ENST00000373091.3	-	2	277	c.261C>T	c.(259-261)caC>caT	p.H87H	GRIK3_ENST00000373093.4_Silent_p.H87H	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	87					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	TGTCATGGAAGTGAATCCTCT	0.532000													51	88					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53804506	53804506	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:53804506T>G	ENST00000288139.3	+	33	4149	c.4031T>G	c.(4030-4032)aTg>aGg	p.M1344R	CACNA1D_ENST00000540742.1_Missense_Mutation_p.M216R|CACNA1D_ENST00000350061.5_Missense_Mutation_p.M1324R|CACNA1D_ENST00000422281.2_Missense_Mutation_p.M1309R	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	1324					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	TTCCGAGTGATGCGATTGGTG	0.468000													6	57					0	0	1	0	0
SLC6A11	6538	broad.mit.edu	37	3	10916678	10916678	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:10916678C>T	ENST00000254488.2	+	6	855	c.789C>T	c.(787-789)atC>atT	p.I263I		NM_014229.1	NP_055044.1	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 11	263					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(13)|ovary(1)|skin(4)	35				OV - Ovarian serous cystadenocarcinoma(96;0.229)		TCCCCTACATCATGCTGCTGA	0.562000													29	159					0	0	1	0	0
PM20D1	148811	broad.mit.edu	37	1	205819153	205819153	+	Silent	SNP	G	G	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:205819153G>T	ENST00000367136.4	-	1	92	c.48C>A	c.(46-48)ctC>ctA	p.L16L	PM20D1_ENST00000460624.1_5'UTR	NM_152491.4	NP_689704.4	Q6GTS8	P20D1_HUMAN	peptidase M20 domain containing 1	16						extracellular region	metal ion binding|peptidase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)	28	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			GGAAAACTAGGAGCAGCATAG	0.602000													18	37					1.01871e-10	1.03558e-10	1	1	0
THAP6	152815	broad.mit.edu	37	4	76442155	76442155	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr4:76442155T>C	ENST00000311638.3	+	3	322	c.254T>C	c.(253-255)aTa>aCa	p.I85T	THAP6_ENST00000508105.1_Missense_Mutation_p.I44T|THAP6_ENST00000380837.3_Missense_Mutation_p.I85T|THAP6_ENST00000507556.1_Missense_Mutation_p.I85T|THAP6_ENST00000507885.1_Missense_Mutation_p.I44T|THAP6_ENST00000502620.1_Missense_Mutation_p.I44T|THAP6_ENST00000514480.1_Missense_Mutation_p.I85T|THAP6_ENST00000504190.1_Missense_Mutation_p.I44T|THAP6_ENST00000507557.1_Missense_Mutation_p.I44T	NM_144721.4	NP_653322.1	Q8TBB0	THAP6_HUMAN	THAP domain containing 6	85						microtubule cytoskeleton	DNA binding|metal ion binding			lung(5)	5			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			CCTGGAGTCATACCTTCTATC	0.343000													13	31					0	0	1	0	0
PRKCB	5579	broad.mit.edu	37	16	24166132	24166132	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:24166132G>A	ENST00000303531.7	+	10	1345	c.1193G>A	c.(1192-1194)gGg>gAg	p.G398E	PRKCB_ENST00000321728.7_Missense_Mutation_p.G398E	NM_002738.6	NP_002729.2	P05771	KPCB_HUMAN	protein kinase C, beta	398	Protein kinase.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			central_nervous_system(3)|large_intestine(1)|lung(2)|ovary(3)	9					Vitamin E(DB00163)	GCCCTGCCTGGGAAGCCGCCC	0.567000													9	26					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9400534	9400534	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr20:9400534T>A	ENST00000378501.2	+	22	2111	c.2096T>A	c.(2095-2097)aTt>aAt	p.I699N	PLCB4_ENST00000334005.3_Missense_Mutation_p.I699N|PLCB4_ENST00000278655.4_Missense_Mutation_p.I699N|PLCB4_ENST00000378493.1_Missense_Mutation_p.I699N|PLCB4_ENST00000378473.3_Missense_Mutation_p.I711N|PLCB4_ENST00000414679.2_Missense_Mutation_p.I711N|PLCB4_ENST00000492632.1_3'UTR	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	699	C2.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						GATGGTGTTATTGCAGCCACT	0.428000													44	73					0	0	1	0	0
HAPLN4	404037	broad.mit.edu	37	19	19369576	19369576	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:19369576G>A	ENST00000291481.7	-	4	636	c.573C>T	c.(571-573)atC>atT	p.I191I	AC138430.4_ENST00000586064.2_RNA	NM_023002.2	NP_075378.1	Q86UW8	HPLN4_HUMAN	hyaluronan and proteoglycan link protein 4	191	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|pancreas(1)|prostate(1)	16			Epithelial(12;0.00575)			CAGATGCCAGGATGCCGTCCT	0.701000													9	17					0	0	1	0	0
PIK3R5	23533	broad.mit.edu	37	17	8794121	8794121	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:8794121G>A	ENST00000447110.1	-	7	715	c.591C>T	c.(589-591)ctC>ctT	p.L197L	PIK3R5_ENST00000581552.1_Silent_p.L197L|PIK3R5_ENST00000584803.1_Silent_p.L197L	NM_001142633.2|NM_001251851.1|NM_001251852.1|NM_001251853.1|NM_001251855.1	NP_001136105.1|NP_001238780.1|NP_001238781.1|NP_001238782.1|NP_001238784.1	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	197					platelet activation	cytosol|membrane|nucleus				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(14)|prostate(3)|skin(4)|urinary_tract(1)	34						AGGCGTGCAGGAGCAGGGTGG	0.632000													14	11					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80762069	80762069	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:80762069G>A	ENST00000458043.2	+	54	6574	c.6568G>A	c.(6568-6570)Gga>Aga	p.G2190R	OTOGL_ENST00000547103.1_Missense_Mutation_p.G2178R|OTOGL_ENST00000546620.1_Missense_Mutation_p.G209R	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						CATGGAAAATGGAACATCAGT	0.403000													4	11					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17482118	17482118	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:17482118C>T	ENST00000302539.4	-	6	1053	c.928G>A	c.(928-930)Gac>Aac	p.D310N	ABCC8_ENST00000389817.3_Missense_Mutation_p.D310N	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	310	ABC transmembrane type-1 1.		D -> N (in HHF1).		carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	CCCAGCAGGTCGGCCAAGATG	0.647000													60	74					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46244258	46244258	+	Silent	SNP	T	T	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:46244258T>A	ENST00000334344.6	+	15	2524	c.2352T>A	c.(2350-2352)ccT>ccA	p.P784P	ARID2_ENST00000422737.1_Silent_p.P635P|ARID2_ENST00000444670.1_Silent_p.P394P|ARID2_ENST00000479608.1_3'UTR	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	784					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		GACAGATCCCTTCAGGCACTC	0.448000			"""N, S, F"""		hepatocellular carcinoma								22	24					0	0	1	0	0
HEATR5B	54497	broad.mit.edu	37	2	37284566	37284566	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr2:37284566G>A	ENST00000233099.5	-	15	2212	c.2117C>T	c.(2116-2118)tCa>tTa	p.S706L	HEATR5B_ENST00000354531.2_Missense_Mutation_p.S706L	NM_019024.1	NP_061897.1	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	706							binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|pancreas(1)|prostate(1)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	77		all_hematologic(82;0.21)				TGTGTTGGCTGAGTTGTCAGT	0.363000													32	5					0	0	1	0	0
GLRA3	8001	broad.mit.edu	37	4	175565068	175565068	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr4:175565068T>A	ENST00000274093.3	-	10	1766	c.1264A>T	c.(1264-1266)Atc>Ttc	p.I422F	GLRA3_ENST00000340217.5_Missense_Mutation_p.I407F	NM_006529.2	NP_006520.2	O75311	GLRA3_HUMAN	glycine receptor, alpha 3	422					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			endometrium(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	35		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	GCCCGGTCGATAAAGACCTTC	0.438000													23	65					0	0	1	0	0
CLEC14A	161198	broad.mit.edu	37	14	38724358	38724358	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr14:38724358C>T	ENST00000342213.2	-	1	1216	c.870G>A	c.(868-870)ggG>ggA	p.G290G		NM_175060.2	NP_778230.1	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	290						integral to membrane	sugar binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(7)|lung(9)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		GCTGTCCTTCCCCACTGGTCA	0.667000													62	70					0	0	1	0	0
SUMO2	6613	broad.mit.edu	37	17	73164461	73164461	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:73164461G>A	ENST00000420826.2	-	4	409	c.261C>T	c.(259-261)ttC>ttT	p.F87F	SUMO2_ENST00000578238.1_Silent_p.F44F|SUMO2_ENST00000314523.7_Silent_p.F63F	NM_006937.3	NP_008868.3	P61956	SUMO2_HUMAN	small ubiquitin-like modifier 2	87	Ubiquitin-like.				positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation	nucleus	ubiquitin protein ligase binding			NS(1)	1	all_lung(278;0.14)|Lung NSC(278;0.168)					TCTGCTGTTGGAACACATCAA	0.353000													7	9					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11058201	11058201	+	RNA	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr21:11058201G>A	ENST00000470054.1	-	0	446									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GACAAAGCAGGAAGATGTGAC	0.398000													9	40					0	0	1	0	0
CDYL2	124359	broad.mit.edu	37	16	80718758	80718758	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:80718758T>C	ENST00000299564.8	-	2	448	c.293A>G	c.(292-294)aAg>aGg	p.K98R	CDYL2_ENST00000566173.1_Missense_Mutation_p.K98R|CDYL2_ENST00000562753.1_5'UTR|CDYL2_ENST00000563890.1_Missense_Mutation_p.K98R|CDYL2_ENST00000562812.1_Missense_Mutation_p.K98R	NM_152342.2	NP_689555.2	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	98						nucleus	catalytic activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	21						CCCCTTGCTCTTTCCAGGATC	0.557000													26	28					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197183898	197183898	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr2:197183898C>T	ENST00000260983.2	-	9	1898	c.1716G>A	c.(1714-1716)gaG>gaA	p.E572E	HECW2_ENST00000409111.1_Silent_p.E216E	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	572					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						GCTGATCTACCTCTTGAGAGC	0.612000													47	14					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71500909	71500909	+	Splice_Site	SNP	A	A	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:71500909A>G	ENST00000296755.7	+	7	7549		c.e7-1			NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B							microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		CTCTCCCTGCAGGTGACACTG	0.408000													26	20					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27561133	27561133	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:27561133G>A	ENST00000356183.4	-	1	94	c.79C>T	c.(79-81)Cgg>Tgg	p.R27W	GTF3C1_ENST00000561623.1_Missense_Mutation_p.R27W	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	27						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						GTCTCCAGCCGGCTCCACAGC	0.667000													26	42					0	0	1	0	0
FKTN	2218	broad.mit.edu	37	9	108377612	108377612	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr9:108377612G>A	ENST00000223528.2	+	7	958	c.834G>A	c.(832-834)aaG>aaA	p.K278K	FKTN_ENST00000357998.5_Silent_p.K278K|FKTN_ENST00000602661.1_Silent_p.K278K|FKTN_ENST00000448551.2_Silent_p.K278K|FKTN_ENST00000540160.1_Intron	NM_006731.2	NP_006722.2	O75072	FKTN_HUMAN	fukutin	278					muscle organ development|negative regulation of cell proliferation|negative regulation of JNK cascade|nervous system development|regulation of protein glycosylation	cis-Golgi network|endoplasmic reticulum|extracellular space|Golgi membrane|integral to membrane|nucleus	transferase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	25						AGAGTGCAAAGGAATTACTGC	0.393000													30	25					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164905723	164905723	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:164905723A>G	ENST00000475390.1	-	2	3339	c.2896T>C	c.(2896-2898)Tac>Cac	p.Y966H	SLITRK3_ENST00000241274.3_Missense_Mutation_p.Y966H			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	966						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						ACTTCGAGGTAATCCGGCTTG	0.388000										HNSCC(40;0.11)			67	85					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196741275	196741275	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr2:196741275T>C	ENST00000312428.6	-	37	6210	c.6110A>G	c.(6109-6111)aAg>aGg	p.K2037R		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2037	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TACCATTCTCTTGCCCAAAGG	0.408000													61	15					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70634255	70634255	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr14:70634255A>C	ENST00000381269.2	-	2	1638	c.885T>G	c.(883-885)caT>caG	p.H295Q	SLC8A3_ENST00000356921.2_Missense_Mutation_p.H295Q|SLC8A3_ENST00000357887.3_Missense_Mutation_p.H295Q|SLC8A3_ENST00000528359.1_Missense_Mutation_p.H295Q|SLC8A3_ENST00000534137.1_Missense_Mutation_p.H295Q	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	295					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		CATCTAGAAAATGGGAATTCA	0.483000													27	30					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94882546	94882546	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr15:94882546A>G	ENST00000357742.4	+	4	665	c.665A>G	c.(664-666)aAg>aGg	p.K222R	MCTP2_ENST00000451018.3_Missense_Mutation_p.K222R|MCTP2_ENST00000331706.4_5'UTR|MCTP2_ENST00000543482.1_Missense_Mutation_p.K222R	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	222	C2 1.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			GTGAAATTTAAGCTGAATGGG	0.333000													31	57					0	0	1	0	0
NFAT5	10725	broad.mit.edu	37	16	69689637	69689637	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:69689637A>T	ENST00000349945.1	+	7	2401	c.849A>T	c.(847-849)gaA>gaT	p.E283D	NFAT5_ENST00000567239.1_Missense_Mutation_p.E377D|NFAT5_ENST00000432919.1_Missense_Mutation_p.E377D|NFAT5_ENST00000354436.2_Missense_Mutation_p.E359D|NFAT5_ENST00000566899.1_Missense_Mutation_p.E283D|NFAT5_ENST00000393742.2_Missense_Mutation_p.E283D	NM_138714.3	NP_619728.2	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5, tonicity-responsive	359	RHD.				excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						CTTGCAAAGAAGTGGACATTG	0.418000													32	57					0	0	1	0	0
HSF1	3297	broad.mit.edu	37	8	145535651	145535651	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr8:145535651C>T	ENST00000528838.1	+	9	1023	c.863C>T	c.(862-864)cCc>cTc	p.P288L	HSF1_ENST00000400780.4_Missense_Mutation_p.P223L	NM_005526.2	NP_005517.1	Q00613	HSF1_HUMAN	heat shock transcription factor 1	288	Regulatory domain.					cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)|lung(3)|prostate(3)|skin(1)|urinary_tract(2)	11	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;1.12e-39)|all cancers(56;9.11e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0547)|Colorectal(110;0.055)			GTGTGCAGGCCCCTATCCAGC	0.721000													8	12					0	0	1	0	0
RALGPS2	55103	broad.mit.edu	37	1	178745903	178745903	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:178745903G>A	ENST00000367635.3	+	2	342	c.4G>A	c.(4-6)Gac>Aac	p.D2N	RALGPS2_ENST00000324778.4_Missense_Mutation_p.D2N|RALGPS2_ENST00000367634.2_Missense_Mutation_p.D2N	NM_152663.3	NP_689876.2	Q86X27	RGPS2_HUMAN	Ral GEF with PH domain and SH3 binding motif 2	2					small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						GGAAAGCATGGACCTAATGAA	0.423000													7	18					0	0	1	0	0
SLC30A10	55532	broad.mit.edu	37	1	220100431	220100431	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:220100431G>A	ENST00000366926.3	-	2	818	c.657C>T	c.(655-657)acC>acT	p.T219T	SLC30A10_ENST00000536446.1_5'UTR	NM_018713.2	NP_061183.2	Q6XR72	ZNT10_HUMAN	solute carrier family 30, member 10	219					zinc ion transport	integral to membrane|plasma membrane	cation transmembrane transporter activity			NS(1)|endometrium(1)|large_intestine(1)|lung(9)|skin(1)	13				GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.209)		GCTCATTCTGGGTGTTGAAGG	0.353000													10	23					0	0	1	0	0
ZNF41	7592	broad.mit.edu	37	X	47307745	47307745	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chrX:47307745G>A	ENST00000377065.4	-	5	2063	c.1424C>T	c.(1423-1425)tCc>tTc	p.S475F	ZNF41_ENST00000313116.7_Missense_Mutation_p.S475F|ZNF41_ENST00000397050.2_Missense_Mutation_p.S485F	NM_153380.2	NP_700359.1	P51814	ZNF41_HUMAN	zinc finger protein 41	517						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|upper_aerodigestive_tract(2)	24		all_lung(315;0.000129)				CTTAGTGAAGGATTTCCCACA	0.433000													19	7					0	0	1	0	0
CNTN4	152330	broad.mit.edu	37	3	2967440	2967440	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:2967440G>A	ENST00000397461.1	+	12	1719	c.1335G>A	c.(1333-1335)agG>agA	p.R445R	CNTN4_ENST00000397459.2_Silent_p.R117R|CNTN4_ENST00000448906.2_Silent_p.R117R|CNTN4_ENST00000475817.1_3'UTR|CNTN4_ENST00000358480.3_Silent_p.R226R|CNTN4_ENST00000427331.1_Silent_p.R445R|CNTN4_ENST00000418658.1_Silent_p.R445R	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	445	Ig-like C2-type 5.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		AGAAAGGAAGGGATATATTAA	0.343000													35	17					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	124988246	124988246	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr8:124988246G>A	ENST00000522917.1	+	9	998	c.792G>A	c.(790-792)gcG>gcA	p.A264A	FER1L6_ENST00000399018.1_Silent_p.A264A	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	264	C2 2.					integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GCATCATGGCGAACGTCACCA	0.507000													90	133					0	0	1	0	0
ARHGEF4	50649	broad.mit.edu	37	2	131704214	131704214	+	Silent	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr2:131704214T>C	ENST00000409359.1	+	4	4199	c.3001T>C	c.(3001-3003)Tta>Cta	p.L1001L	ARHGEF4_ENST00000392953.3_Intron|ARHGEF4_ENST00000525839.1_Intron|ARHGEF4_ENST00000326016.5_Intron|ARHGEF4_ENST00000409303.1_Intron|ARHGEF4_ENST00000428230.2_Intron			Q9NR80	ARHG4_HUMAN	Rho guanine nucleotide exchange factor (GEF) 4	0					apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|lamellipodium assembly|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|ruffle membrane	protein domain specific binding|Rac guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|cervix(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(3)|pancreas(1)|prostate(1)|skin(4)	29		Prostate(154;0.055)		BRCA - Breast invasive adenocarcinoma(221;0.097)		CACTGGTGAGTTACGCGCCTC	0.532000													63	15					0	0	1	0	0
NAP1L3	4675	broad.mit.edu	37	X	92926850	92926850	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chrX:92926850G>T	ENST00000373079.3	-	1	1717	c.1454C>A	c.(1453-1455)aCt>aAt	p.T485N	NAP1L3_ENST00000475430.1_5'UTR	NM_004538.5	NP_004529.2	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	485					nucleosome assembly	chromatin assembly complex				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	34						GACTTCTCCAGTATAGTAATA	0.343000													12	3					2.27111e-07	2.2973e-07	1	1	0
RAG1	5896	broad.mit.edu	37	11	36596233	36596233	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:36596233G>A	ENST00000299440.5	+	2	1491	c.1379G>A	c.(1378-1380)gGa>gAa	p.G460E		NM_000448.2	NP_000439.1	P15918	RAG1_HUMAN	recombination activating gene 1	460					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	65	all_lung(20;0.226)	all_hematologic(20;0.107)				ATCATGCAGGGAAAGGGCTCT	0.567000									Familial Hemophagocytic Lymphohistiocytosis				25	44					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21258488	21258488	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr2:21258488C>T	ENST00000233242.1	-	7	913	c.786G>A	c.(784-786)aaG>aaA	p.K262K	APOB_ENST00000399256.4_Silent_p.K262K	NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	262	Heparin-binding.|Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GGTGTTGCTCCTTGCAGATGG	0.498000													38	11					0	0	1	0	0
CHRM2	1129	broad.mit.edu	37	7	136699916	136699916	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:136699916C>G	ENST00000445907.2	+	3	832	c.304C>G	c.(304-306)Ctg>Gtg	p.L102V	CHRM2_ENST00000402486.3_Missense_Mutation_p.L102V|AC009264.1_ENST00000425981.2_RNA|CHRM2_ENST00000320658.5_Missense_Mutation_p.L102V|AC009264.1_ENST00000598184.1_RNA|CHRM2_ENST00000453373.1_Missense_Mutation_p.L102V|AC009264.1_ENST00000439694.1_RNA|AC009264.1_ENST00000597642.1_RNA|AC009264.1_ENST00000593789.1_RNA|CHRM2_ENST00000401861.1_Missense_Mutation_p.L102V|AC009264.1_ENST00000592183.1_RNA|AC009264.1_ENST00000586239.1_RNA|CHRM2_ENST00000397608.3_Missense_Mutation_p.L102V	NM_001006627.1|NM_001006629.1	NP_001006628.1|NP_001006630.1	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	102					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(13)|liver(1)|lung(29)|ovary(4)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	68					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	TTGGCTAGCCCTGGACTATGT	0.478000													60	122					0	0	1	0	0
HOOK2	29911	broad.mit.edu	37	19	12881844	12881844	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:12881844C>T	ENST00000264827.5	-	10	974	c.804G>A	c.(802-804)gaG>gaA	p.E268E	HOOK2_ENST00000397668.3_Silent_p.E268E|HOOK2_ENST00000589965.1_Intron	NM_001100176.1	NP_001093646.1	Q96ED9	HOOK2_HUMAN	hook microtubule-tethering protein 2	268	Sufficient for interaction with microtubules.				early endosome to late endosome transport|endocytosis|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|protein transport	centrosome|FHF complex|microtubule	identical protein binding|microtubule binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(5)|skin(1)	20						CCCTCTCCAGCTCGGCACAGC	0.667000													9	19					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21147748	21147748	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:21147748C>T	ENST00000261383.3	-	6	782	c.783G>A	c.(781-783)ctG>ctA	p.L261L	DNAH3_ENST00000415178.1_Silent_p.L261L	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	261	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TGTTAGAAATCAGCTTTGAAA	0.463000													49	103					0	0	1	0	0
NAALAD2	10003	broad.mit.edu	37	11	89868803	89868803	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:89868803C>T	ENST00000534061.1	+	2	389	c.159C>T	c.(157-159)tcC>tcT	p.S53S	NAALAD2_ENST00000525171.1_Silent_p.S53S|NAALAD2_ENST00000375944.3_Silent_p.S53S|NAALAD2_ENST00000321955.4_Silent_p.S53S	NM_005467.3	NP_005458.1	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	53					proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(32)|pancreas(1)|prostate(3)|skin(5)|stomach(2)	59		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				AACTGGTATCCGAAATGAAAG	0.328000													20	37					0	0	1	0	0
THBS4	7060	broad.mit.edu	37	5	79355629	79355629	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:79355629C>T	ENST00000350881.2	+	7	1078	c.888C>T	c.(886-888)ttC>ttT	p.F296F	THBS4_ENST00000511733.1_Silent_p.F205F|CTD-2201I18.1_ENST00000503007.1_RNA	NM_003248.4	NP_003239.2	P35443	TSP4_HUMAN	thrombospondin 4	296	EGF-like 1.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|stomach(3)	34		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		ACCCATGTTTCCGAGGTGTCC	0.602000													111	49					0	0	1	0	0
DISP1	84976	broad.mit.edu	37	1	223176194	223176194	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:223176194C>T	ENST00000284476.6	+	8	1619	c.1455C>T	c.(1453-1455)acC>acT	p.T485T		NM_032890.3	NP_116279.2	Q96F81	DISP1_HUMAN	dispatched homolog 1 (Drosophila)	485					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(20)|lung(25)|prostate(4)|skin(1)|stomach(1)|urinary_tract(5)	69				GBM - Glioblastoma multiforme(131;0.102)		CTACCATCACCGGGATTGAGT	0.423000													37	46					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104106188	104106188	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:104106188G>A	ENST00000388887.2	+	41	4582	c.4378G>A	c.(4378-4380)Gca>Aca	p.A1460T		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	1460	EGF-like 11.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						CAAGTGTGCAGCAGGATTCCA	0.517000													25	54					0	0	1	0	0
FBXO18	84893	broad.mit.edu	37	10	5950915	5950915	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr10:5950915C>T	ENST00000379999.5	+	5	1038	c.934C>T	c.(934-936)Cga>Tga	p.R312*	FBXO18_ENST00000397269.3_5'UTR|FBXO18_ENST00000362091.4_Nonsense_Mutation_p.R261*|FBXO18_ENST00000470089.1_3'UTR|FBXO18_ENST00000379994.1_5'UTR	NM_032807.4	NP_116196.3	Q8NFZ0	FBX18_HUMAN	F-box protein, helicase, 18	261					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|breast(2)|kidney(2)|large_intestine(16)|lung(9)|ovary(2)|prostate(3)|skin(3)|stomach(1)	40						GCTGTACCATCGATACCTGAT	0.443000													44	61					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	166986974	166986974	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr4:166986974A>G	ENST00000061240.2	+	16	2794	c.2147A>G	c.(2146-2148)aAt>aGt	p.N716S	TLL1_ENST00000507499.1_Missense_Mutation_p.N739S	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	716	CUB 3.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		AAATCTGACAATACTGTATCC	0.378000													29	29					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9083313	9083313	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:9083313C>T	ENST00000397910.4	-	1	8705	c.8502G>A	c.(8500-8502)acG>acA	p.T2834T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2834	Ser-rich.|Thr-rich.		T -> M (in dbSNP:rs10407623).		cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCAGTCTGTTCGTGGTGATTT	0.507000													10	22					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178418504	178418504	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:178418504A>G	ENST00000231188.5	-	3	956	c.778T>C	c.(778-780)Ttc>Ctc	p.F260L	GRM6_ENST00000517717.1_Missense_Mutation_p.F260L	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	260					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		ACCTTGCTGAACTCTCCTGGC	0.582000													94	54					0	0	1	0	0
RNF40	9810	broad.mit.edu	37	16	30779946	30779946	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:30779946C>T	ENST00000324685.6	+	14	2421	c.1986C>T	c.(1984-1986)gcC>gcT	p.A662A	RNF40_ENST00000563683.1_Silent_p.A622A|RNF40_ENST00000357890.5_Silent_p.A562A|RNF40_ENST00000402121.3_Silent_p.A354A	NM_001207033.1|NM_014771.3	NP_001193962.1|NP_055586.1	O75150	BRE1B_HUMAN	ring finger protein 40, E3 ubiquitin protein ligase	662					histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)	30			Colorectal(24;0.198)			CCAGGAAGGCCCAGGAGAGCC	0.577000													25	42					0	0	1	0	0
JMJD6	23210	broad.mit.edu	37	17	74719898	74719898	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:74719898G>A	ENST00000445478.2	-	3	964	c.761C>T	c.(760-762)cCc>cTc	p.P254L	JMJD6_ENST00000585429.1_Missense_Mutation_p.P254L|JMJD6_ENST00000397625.4_Missense_Mutation_p.P254L	NM_001081461.1	NP_001074930.1	Q6NYC1	JMJD6_HUMAN	jumonji domain containing 6	254	JmjC.				mRNA processing|peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine|regulation of nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|RNA splicing|sprouting angiogenesis|transcription, DNA-dependent	nucleolus|nucleoplasm	histone demethylase activity (H3-R2 specific)|histone demethylase activity (H4-R3 specific)|identical protein binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-lysine 5-dioxygenase activity|single-stranded RNA binding			endometrium(2)|kidney(5)|large_intestine(2)|lung(3)|ovary(2)|skin(2)	16						GATTTCCAGGGGTTTGAATTC	0.483000													26	62					0	0	1	0	0
ZNF382	84911	broad.mit.edu	37	19	37117340	37117340	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:37117340C>G	ENST00000435416.1	+	3	2033	c.538C>G	c.(538-540)Cct>Gct	p.P180A	ZNF382_ENST00000423582.1_Missense_Mutation_p.P132A|ZNF382_ENST00000439428.1_Missense_Mutation_p.P180A|ZNF382_ENST00000292928.2_Missense_Mutation_p.P181A			Q96SR6	ZN382_HUMAN	zinc finger protein 382	181	Represses transcription (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	34	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			GAAAATTCATCCTGCAGTGAA	0.403000													22	92					0	0	1	0	0
OR2T1	26696	broad.mit.edu	37	1	248570260	248570260	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:248570260A>C	ENST00000366474.1	+	1	965	c.965A>C	c.(964-966)aAa>aCa	p.K322T		NM_030904.1	NP_112166.1	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T, member 1	322					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	39	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCCCAGGACAAAGTCCTCTCT	0.522000													88	106					0	0	1	0	0
SLC4A7	9497	broad.mit.edu	37	3	27478888	27478888	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:27478888T>C	ENST00000295736.5	-	4	462	c.392A>G	c.(391-393)gAa>gGa	p.E131G	SLC4A7_ENST00000428386.1_Missense_Mutation_p.E131G|SLC4A7_ENST00000437179.1_Missense_Mutation_p.E136G|SLC4A7_ENST00000445684.1_Missense_Mutation_p.E140G|SLC4A7_ENST00000454389.1_Missense_Mutation_p.E140G|SLC4A7_ENST00000425128.2_Missense_Mutation_p.E136G|SLC4A7_ENST00000388777.4_5'UTR|SLC4A7_ENST00000446700.1_Missense_Mutation_p.E136G|SLC4A7_ENST00000455077.1_Missense_Mutation_p.E136G|SLC4A7_ENST00000435667.2_Missense_Mutation_p.E140G|SLC4A7_ENST00000440156.1_Missense_Mutation_p.E140G	NM_003615.4	NP_003606.3	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 7	131						apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(9)|ovary(4)|skin(1)	38						CCTAGCAGTTTCTTTCCATTC	0.423000													16	19					0	0	1	0	0
RASGEF1C	255426	broad.mit.edu	37	5	179564879	179564879	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:179564879G>A	ENST00000393371.2	-	1	470	c.174C>T	c.(172-174)ccC>ccT	p.P58P	RASGEF1C_ENST00000361132.4_Silent_p.P58P			Q8N431	RGF1C_HUMAN	RasGEF domain family, member 1C	58	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity			breast(1)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|stomach(1)	12	all_cancers(89;3.44e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0242)|Medulloblastoma(196;0.00498)|all_neural(177;0.0137)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CACCCACCTCGGGGTAGTAGT	0.672000													14	8					0	0	1	0	0
NEFL	4747	broad.mit.edu	37	8	24813676	24813676	+	RNA	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr8:24813676C>T	ENST00000221169.5	-	0	948							P07196	NFL_HUMAN	neurofilament, light polypeptide						anterograde axon cargo transport|axon transport of mitochondrion|neurofilament bundle assembly|retrograde axon cargo transport|synaptic transmission	cytosol|neurofilament	identical protein binding|protein C-terminus binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(2)	21		Ovarian(32;0.00965)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		GCTCGGCTTCCAGGACCTTGT	0.667000													9	10					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31393158	31393158	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:31393158T>C	ENST00000268296.4	+	30	3543	c.3422T>C	c.(3421-3423)aTg>aCg	p.M1141T	ITGAX_ENST00000562522.1_Missense_Mutation_p.M1141T	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	1141					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						AAGGAAATGATGGAGGAGGCA	0.522000													54	69					0	0	1	0	0
TRHR	7201	broad.mit.edu	37	8	110131307	110131307	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr8:110131307C>T	ENST00000518632.1	+	3	1171	c.820C>T	c.(820-822)Ctg>Ttg	p.L274L	TRHR_ENST00000311762.2_Silent_p.L274L			P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	274						integral to plasma membrane	thyrotropin-releasing hormone receptor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(12)|prostate(4)|skin(4)|urinary_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			GGTTGTAATTCTGTTTGCCCT	0.408000													104	175					0	0	1	0	0
NTSR1	4923	broad.mit.edu	37	20	61391401	61391401	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr20:61391401A>C	ENST00000370501.3	+	4	1410	c.1039A>C	c.(1039-1041)Atg>Ctg	p.M347L	NTSR1_ENST00000482259.1_3'UTR	NM_002531.2	NP_002522.2	P30989	NTR1_HUMAN	neurotensin receptor 1 (high affinity)	347						endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(16)|prostate(1)|skin(3)	27	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)			CTACTTCTACATGGTGACCAA	0.572000													86	119					0	0	1	0	0
SLC26A3	1811	broad.mit.edu	37	7	107415298	107415298	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:107415298C>T	ENST00000340010.5	-	16	1881	c.1697G>A	c.(1696-1698)cGa>cAa	p.R566Q	SLC26A3_ENST00000422236.2_Missense_Mutation_p.R531Q	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	566	STAS.				excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						GCGTAGAATTCGAAGTGGACT	0.398000													27	40					0	0	1	0	0
AGR2	10551	broad.mit.edu	37	7	16841421	16841421	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:16841421G>A	ENST00000419572.2	-	2	59	c.60C>T	c.(58-60)gcC>gcT	p.A20A	AGR2_ENST00000401412.1_5'UTR|AGR2_ENST00000419304.2_5'UTR			O95994	AGR2_HUMAN	anterior gradient 2	0					mucus secretion	endoplasmic reticulum|extracellular region	protein binding			endometrium(2)|lung(1)|prostate(1)|skin(2)	6	Lung NSC(10;0.0376)|all_lung(11;0.0855)			UCEC - Uterine corpus endometrioid carcinoma (126;0.184)		TTTTCTCCATGGCAACTCTAG	0.463000													16	22					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70332489	70332489	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:70332489C>T	ENST00000338508.4	-	32	3911	c.3912G>A	c.(3910-3912)atG>atA	p.M1304I	SHANK2_ENST00000449833.2_Missense_Mutation_p.M708I|SHANK2_ENST00000423696.2_Missense_Mutation_p.M924I|SHANK2_ENST00000409161.1_Missense_Mutation_p.M707I			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	924					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GGGACGTGTCCATGATGTCGA	0.612000													48	71					0	0	1	0	0
CARD18	59082	broad.mit.edu	37	11	105009723	105009723	+	Silent	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:105009723T>C	ENST00000530950.1	-	2	89	c.90A>G	c.(88-90)ttA>ttG	p.L30L	CARD18_ENST00000532895.1_5'UTR|CARD18_ENST00000526823.1_5'UTR	NM_021571.3	NP_067546.1	P57730	CAR18_HUMAN	caspase recruitment domain family, member 18	30	CARD.				inflammatory response|regulation of apoptosis	intracellular	cysteine-type endopeptidase inhibitor activity			central_nervous_system(1)|ovary(1)	2						CTTCATCCTCTAATAGGCAAT	0.408000													45	50					0	0	1	0	0
IL12A-AS1	101928376	broad.mit.edu	37	3	159819924	159819924	+	RNA	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:159819924G>A	ENST00000497452.1	-	0	517																											AACCTATGGGGAAGACTCTGA	0.408000													20	22					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228548416	228548416	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:228548416T>G	ENST00000284548.11	+	81	19897	c.19823T>G	c.(19822-19824)aTc>aGc	p.I6608S	OBSCN_ENST00000366709.4_Missense_Mutation_p.I3727S|OBSCN_ENST00000422127.1_Intron|OBSCN_ENST00000570156.2_Intron|OBSCN_ENST00000366707.4_Intron			Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	0	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				ACCCTTCACATCTGCCCAGAC	0.627000													6	22					0	0	1	0	0
SLC1A3	6507	broad.mit.edu	37	5	36629559	36629559	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:36629559C>T	ENST00000265113.4	+	3	665	c.189C>T	c.(187-189)atC>atT	p.I63I	SLC1A3_ENST00000381918.3_Silent_p.I63I	NM_004172.4	NP_004163.3	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity glutamate transporter), member 3	63					D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(23)|skin(1)	41	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	CAGGTACAATCCTTGGATTTA	0.398000													23	30					0	0	1	0	0
INTS2	57508	broad.mit.edu	37	17	59962266	59962266	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:59962266C>T	ENST00000444766.3	-	16	2184	c.2109G>A	c.(2107-2109)ttG>ttA	p.L703L	INTS2_ENST00000251334.6_Silent_p.L695L	NM_020748.2	NP_065799.1	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	703					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			NS(1)|breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	38						ACATACCTCCCAACTCCTGCT	0.338000													6	11					0	0	1	0	0
TRIM44	54765	broad.mit.edu	37	11	35706842	35706842	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:35706842C>T	ENST00000299413.5	+	2	1012	c.705C>T	c.(703-705)atC>atT	p.I235I		NM_017583.4	NP_060053.2	Q96DX7	TRI44_HUMAN	tripartite motif containing 44	235						intracellular	protein binding|zinc ion binding			endometrium(1)|large_intestine(8)|lung(4)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	18	all_lung(20;0.0317)|Lung NSC(22;0.0661)|all_epithelial(35;0.115)	all_hematologic(20;0.107)				CCGCTATGATCGAATTGGTGG	0.433000													24	31					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215846992	215846992	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr2:215846992C>G	ENST00000272895.7	-	30	4717	c.4498G>C	c.(4498-4500)Gta>Cta	p.V1500L	ABCA12_ENST00000389661.4_Missense_Mutation_p.V1182L	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	1500	ABC transporter 1.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TCCAAAATTACTACCCTTGAT	0.413000													57	17					0	0	1	0	0
IKZF4	64375	broad.mit.edu	37	12	56428832	56428832	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:56428832C>T	ENST00000262032.5	+	12	1842	c.1475C>T	c.(1474-1476)cCt>cTt	p.P492L	IKZF4_ENST00000431367.2_Missense_Mutation_p.P390L|RP11-603J24.4_ENST00000551846.1_RNA|IKZF4_ENST00000547791.1_Missense_Mutation_p.P447L|IKZF4_ENST00000547167.1_Missense_Mutation_p.P492L			Q9H2S9	IKZF4_HUMAN	IKAROS family zinc finger 4 (Eos)	492					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|lung(3)|ovary(1)|prostate(1)	8			UCEC - Uterine corpus endometrioid carcinoma (6;0.025)|OV - Ovarian serous cystadenocarcinoma(18;0.123)			CGGCACAGTCCTGCCTACGCC	0.652000													29	35					0	0	1	0	0
SBF2	81846	broad.mit.edu	37	11	10052609	10052609	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:10052609G>A	ENST00000256190.8	-	4	525	c.388C>T	c.(388-390)Cca>Tca	p.P130S	SBF2_ENST00000527019.1_5'UTR	NM_030962.3	NP_112224.1	Q86WG5	MTMRD_HUMAN	SET binding factor 2	130	DENN.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			breast(4)|endometrium(8)|kidney(2)|large_intestine(8)|lung(16)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		AAAATTTCTGGATAATATAAT	0.353000													33	56					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	71031154	71031154	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:71031154C>T	ENST00000334414.6	-	1	66	c.22G>A	c.(22-24)Gtg>Atg	p.V8M	PTPRB_ENST00000538174.2_5'UTR|PTPRB_ENST00000551525.1_Missense_Mutation_p.V8M|PTPRB_ENST00000550358.1_Missense_Mutation_p.V8M	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	0					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GTAAGAATCACCATGTAAAAT	0.448000													8	22					0	0	1	0	0
UBBP4	23666	broad.mit.edu	37	17	21731144	21731144	+	Missense_Mutation	SNP	T	T	G	rs149119138	by1000genomes	TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:21731144T>G	ENST00000584755.1	+	2	843	c.446T>G	c.(445-447)cTg>cGg	p.L149R	UBBP4_ENST00000583708.1_3'UTR|UBBP4_ENST00000578713.1_Missense_Mutation_p.L149R|UBBP4_ENST00000584398.1_3'UTR														p.L149R(18)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCTGAGAGGTGGT	0.542000													5	101					0	0	1	0	0
ZNF610	162963	broad.mit.edu	37	19	52856990	52856990	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:52856990C>T	ENST00000601151.1	+	4	571	c.119C>T	c.(118-120)tCc>tTc	p.S40F	ZNF610_ENST00000403906.3_Missense_Mutation_p.S40F|ZNF610_ENST00000327920.8_Missense_Mutation_p.S40F|ZNF610_ENST00000321287.8_Missense_Mutation_p.S40F	NM_001161427.1	NP_001154899.1	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610	40	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(8)|liver(2)|lung(9)|ovary(2)|stomach(2)|upper_aerodigestive_tract(2)	34				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		GAGTGGAAATCCCTGGACCCT	0.488000													22	82					0	0	1	0	0
GFOD2	81577	broad.mit.edu	37	16	67719524	67719524	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:67719524G>A	ENST00000268797.7	-	2	440	c.95C>T	c.(94-96)gCc>gTc	p.A32V	GFOD2_ENST00000602377.1_5'UTR	NM_030819.3	NP_110446.3	Q3B7J2	GFOD2_HUMAN	glucose-fructose oxidoreductase domain containing 2	32						proteinaceous extracellular matrix	binding|oxidoreductase activity			breast(2)|endometrium(1)|large_intestine(4)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0151)|Epithelial(162;0.0505)|all cancers(182;0.242)		CCCCCACAGGGCCTCAACAGT	0.587000													34	31					0	0	1	0	0
OR2B11	127623	broad.mit.edu	37	1	247615124	247615124	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:247615124C>T	ENST00000318749.6	-	1	184	c.161G>A	c.(160-162)cGg>cAg	p.R54Q		NM_001004492.1	NP_001004492.1	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B, member 11	54					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(13)|large_intestine(7)|lung(31)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	60	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			AGGATCCACCCGGGATGCCAG	0.587000													61	66					0	0	1	0	0
RAPGEFL1	51195	broad.mit.edu	37	17	38346934	38346934	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:38346934G>A	ENST00000436615.3	+	8	1127	c.637G>A	c.(637-639)Gag>Aag	p.E213K	RAPGEFL1_ENST00000456989.2_Missense_Mutation_p.E268K|RAPGEFL1_ENST00000540388.1_3'UTR|RAPGEFL1_ENST00000544503.1_Missense_Mutation_p.E262K|RAPGEFL1_ENST00000264644.6_Missense_Mutation_p.E213K	NM_016339.3	NP_057423.1	Q9UHV5	RPGFL_HUMAN	Rap guanine nucleotide exchange factor (GEF)-like 1	419					G-protein coupled receptor protein signaling pathway|nervous system development|small GTPase mediated signal transduction	intracellular|membrane fraction	guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(1)	15						TGGAGACACAGAGATCCACCG	0.647000													73	95					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89395185	89395185	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr15:89395185C>T	ENST00000439576.2	+	11	2561	c.2187C>T	c.(2185-2187)atC>atT	p.I729I	ACAN_ENST00000561243.1_Silent_p.I729I|ACAN_ENST00000559004.1_Silent_p.I729I|ACAN_ENST00000352105.7_Silent_p.I729I	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	729					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CTACTGCCATCCTAGAGTTCA	0.577000													11	8					0	0	1	0	0
OAS3	4940	broad.mit.edu	37	12	113405393	113405393	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:113405393C>T	ENST00000228928.7	+	13	3039	c.2860C>T	c.(2860-2862)Cag>Tag	p.Q954*	RP1-71H24.1_ENST00000552784.1_RNA	NM_006187.2	NP_006178.2	Q9Y6K5	OAS3_HUMAN	2'-5'-oligoadenylate synthetase 3, 100kDa	954	OAS domain 3.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|skin(2)	27						GCACTGGTACCAGCAGGTTCG	0.592000													9	16					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111397596	111397596	+	Missense_Mutation	SNP	C	C	T	rs147278588		TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr4:111397596C>T	ENST00000265162.5	+	1	368	c.26C>T	c.(25-27)tCt>tTt	p.S9F		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	9					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	AGAGAGGGCTCTAAGAGATAC	0.433000													61	83					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4714902	4714902	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:4714902G>A	ENST00000302640.8	+	20	2592	c.2242G>A	c.(2242-2244)Gat>Aat	p.D748N	ITPR1_ENST00000423119.2_Missense_Mutation_p.D763N|ITPR1_ENST00000456211.2_Missense_Mutation_p.D748N|ITPR1_ENST00000354582.6_Missense_Mutation_p.D763N|ITPR1_ENST00000357086.4_Missense_Mutation_p.D763N|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000443694.2_Missense_Mutation_p.D748N	NM_001168272.1	NP_001161744.1	Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	763					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		GCTGGATGTCGATCTCATTCT	0.547000													20	10					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50985631	50985631	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr18:50985631G>A	ENST00000442544.2	+	24	4038	c.3422G>A	c.(3421-3423)aGg>aAg	p.R1141K	DCC_ENST00000581580.1_Missense_Mutation_p.R776K	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	1141					apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GCTGGCAAAAGGAAGGGCAGC	0.468000													20	35					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1270510	1270510	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:1270510C>T	ENST00000348261.5	+	35	6826	c.6578C>T	c.(6577-6579)tCg>tTg	p.S2193L	CACNA1H_ENST00000565831.1_Missense_Mutation_p.S2187L|CACNA1H_ENST00000358590.4_Missense_Mutation_p.S2187L	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	2193					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CCCTGCATCTCGGTGGAACCC	0.731000													29	48					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23509152	23509152	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:23509152G>A	ENST00000296682.3	+	2	192	c.10G>A	c.(10-12)Gaa>Aaa	p.E4K		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	4					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						CATGAGCCCTGAAAAGTCCCA	0.572000										HNSCC(3;0.000094)			9	18					0	0	1	0	0
ARMC3	219681	broad.mit.edu	37	10	23297853	23297853	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr10:23297853G>A	ENST00000298032.5	+	16	2122	c.2038G>A	c.(2038-2040)Gga>Aga	p.G680R	ARMC3_ENST00000409049.3_Missense_Mutation_p.G680R|ARMC3_ENST00000409983.3_Missense_Mutation_p.G673R|ARMC3_ENST00000376528.4_Missense_Mutation_p.G417R	NM_173081.3	NP_775104.2	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	680							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						CAAAGAAAAAGGATGGAGGTA	0.473000													7	18					0	0	1	0	0
CCRN4L	25819	broad.mit.edu	37	4	139965950	139965950	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr4:139965950C>T	ENST00000280614.2	+	3	811	c.618C>T	c.(616-618)ctC>ctT	p.L206L	ELF2_ENST00000515489.1_Intron	NM_012118.2	NP_036250.2	Q9UK39	NOCT_HUMAN	CCR4 carbon catabolite repression 4-like (S. cerevisiae)	206					rhythmic process|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			kidney(2)|large_intestine(3)|lung(3)|ovary(1)	9	all_hematologic(180;0.162)					TCCAGCCACTCCTCAGTAGAC	0.463000													26	54					0	0	1	0	0
ZBTB14	7541	broad.mit.edu	37	18	5291481	5291481	+	Silent	SNP	A	A	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr18:5291481A>G	ENST00000357006.4	-	4	1064	c.726T>C	c.(724-726)aaT>aaC	p.N242N	ZBTB14_ENST00000400143.3_Silent_p.N242N	NM_001143823.2|NM_001243704.1	NP_001137295.1|NP_001230633.1			zinc finger and BTB domain containing 14																		TCATCCCATCATTAAATGTTA	0.483000													42	61					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31324403	31324403	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr18:31324403G>A	ENST00000269197.5	+	12	4591	c.4591G>A	c.(4591-4593)Gaa>Aaa	p.E1531K		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1531					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						AGTTGCCAACGAAGGTATAGA	0.542000											OREG0024911	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	15					0	0	1	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21794180	21794180	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr14:21794180T>G	ENST00000206660.6	+	16	2558	c.2558T>G	c.(2557-2559)tTc>tGc	p.F853C	RPGRIP1_ENST00000382933.4_Intron|RPGRIP1_ENST00000557771.1_Missense_Mutation_p.F815C|RPGRIP1_ENST00000307974.4_Missense_Mutation_p.F212C|RPGRIP1_ENST00000400017.2_Missense_Mutation_p.F853C|RPGRIP1_ENST00000556336.1_Intron			Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator interacting protein 1	853	C2.				response to stimulus|visual perception	cilium				breast(3)|endometrium(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(4)|pancreas(1)|prostate(3)|stomach(1)	39	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		CAGGCTCGATTCCCAGTGCTT	0.488000													25	39					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45846587	45846587	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr21:45846587G>A	ENST00000397928.1	+	26	4285	c.3840G>A	c.(3838-3840)agG>agA	p.R1280R	TRPM2_ENST00000300481.9_Silent_p.R1260R|TRPM2_ENST00000397932.2_Silent_p.R1330R|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300482.5_Silent_p.R1280R	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	1280						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						CGGCAGAGAGGAAGGACGCGG	0.597000													35	85					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183549964	183549964	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr4:183549964T>C	ENST00000511685.1	+	5	1033	c.910T>C	c.(910-912)Tac>Cac	p.Y304H	TENM3_ENST00000406950.2_Missense_Mutation_p.Y304H					teneurin transmembrane protein 3																		GTCTTCAAAGTACTGTAGCTG	0.428000													4	10					0	0	1	0	0
DHX34	9704	broad.mit.edu	37	19	47879315	47879315	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:47879315C>T	ENST00000328771.4	+	11	2791	c.2442C>T	c.(2440-2442)gtC>gtT	p.V814V		NM_014681.5	NP_055496.2	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	814						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(5)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		AGCTGGCCGTCCCCGACGCCT	0.652000													38	37					0	0	1	0	0
C16orf62	57020	broad.mit.edu	37	16	19711759	19711759	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:19711759G>A	ENST00000438132.3	+	31	3168	c.3120G>A	c.(3118-3120)acG>acA	p.T1040T	C16orf62_ENST00000417362.2_Silent_p.T858T|C16orf62_ENST00000543152.1_Silent_p.T700T|C16orf62_ENST00000542263.1_Silent_p.T947T|C16orf62_ENST00000448695.1_Silent_p.T801T|C16orf62_ENST00000251143.5_Silent_p.T951T	NM_020314.5	NP_064710.4	Q7Z3J2	CP062_HUMAN	chromosome 16 open reading frame 62	951						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	36						CTCATCTGACGGAGCTGGCCC	0.507000													23	51					0	0	1	0	0
PNN	5411	broad.mit.edu	37	14	39649733	39649733	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr14:39649733T>A	ENST00000216832.4	+	9	887	c.820T>A	c.(820-822)Ttt>Att	p.F274I	PNN_ENST00000557680.1_3'UTR	NM_002687.3	NP_002678.2	Q9H307	PININ_HUMAN	pinin, desmosome associated protein	274	Glu-rich.|Necessary for interaction with RNPS1.				cell adhesion|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|desmosome|intermediate filament|nuclear speck	DNA binding|protein binding|structural molecule activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(2)|stomach(1)	27	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0119)		ACGCATCGAATTTGCAGAACA	0.338000													10	15					0	0	1	0	0
ADSL	158	broad.mit.edu	37	22	40757276	40757276	+	Splice_Site	SNP	G	G	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr22:40757276G>T	ENST00000216194.7	+	8	848		c.e8-1		ADSL_ENST00000342312.6_Splice_Site|ADSL_ENST00000480775.1_3'UTR|ADSL_ENST00000454266.2_Splice_Site	NM_000026.2	NP_000017.1	P30566	PUR8_HUMAN	adenylosuccinate lyase						AMP biosynthetic process|protein tetramerization|purine base metabolic process	cytosol	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(2)|ovary(1)|prostate(1)	19						ACCTCCCCCAGATTTGCACCG	0.522000													70	239					1.37693e-34	1.41377e-34	1	1	0
USP19	10869	broad.mit.edu	37	3	49154675	49154675	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:49154675G>A	ENST00000453664.1	-	6	1014	c.696C>T	c.(694-696)gcC>gcT	p.A232A	USP19_ENST00000398892.3_Silent_p.A179A|USP19_ENST00000417901.1_Silent_p.A242A|USP19_ENST00000398888.2_Intron|USP19_ENST00000398896.1_Intron|USP19_ENST00000398898.2_Silent_p.A179A|USP19_ENST00000488993.1_5'UTR|USP19_ENST00000434032.2_Silent_p.A242A	NM_001199161.1|NM_001199162.1	NP_001186090.1|NP_001186091.1	O94966	UBP19_HUMAN	ubiquitin specific peptidase 19	0					ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(10)|lung(5)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TCTGGTTCCGGGCCTCCTGCT	0.716000													5	1					0	0	1	0	0
UGT1A6	54578	broad.mit.edu	37	2	234602173	234602173	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr2:234602173C>T	ENST00000305139.6	+	1	662	c.523C>T	c.(523-525)Ccg>Tcg	p.P175S	UGT1A10_ENST00000373445.1_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000480628.1_Intron|UGT1A9_ENST00000354728.4_Intron|AC114812.8_ENST00000439336.1_RNA|UGT1A6_ENST00000373424.1_Intron	NM_001072.3	NP_001063.2														central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|skin(1)|upper_aerodigestive_tract(1)	22		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;5.86e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000384)|Lung(119;0.00306)|LUSC - Lung squamous cell carcinoma(224;0.00702)		CAGGGGTTTTCCGTGTTCCCT	0.507000													142	30					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82432134	82432134	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:82432134C>T	ENST00000370728.1	+	15	2823	c.2178C>T	c.(2176-2178)ttC>ttT	p.F726F	LPHN2_ENST00000335786.5_Silent_p.F726F|LPHN2_ENST00000370723.1_Silent_p.F713F|LPHN2_ENST00000271029.4_Silent_p.F726F|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000370730.1_Silent_p.F726F|LPHN2_ENST00000370721.1_Silent_p.F651F|LPHN2_ENST00000394879.1_Silent_p.F713F|LPHN2_ENST00000319517.6_Silent_p.F713F|LPHN2_ENST00000370713.1_Silent_p.F713F|LPHN2_ENST00000370715.1_Silent_p.F713F|LPHN2_ENST00000370725.1_Silent_p.F726F|LPHN2_ENST00000370717.2_Silent_p.F726F|LPHN2_ENST00000370727.1_Silent_p.F726F|LPHN2_ENST00000359929.3_Silent_p.F713F			O95490	LPHN2_HUMAN	latrophilin 2	726					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TGGGACAGTTCCTTAGTACAG	0.383000													24	48					0	0	1	0	0
PRICKLE1	144165	broad.mit.edu	37	12	42858961	42858961	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:42858961G>A	ENST00000455697.1	-	7	1160	c.875C>T	c.(874-876)cCc>cTc	p.P292L	PRICKLE1_ENST00000445766.2_Missense_Mutation_p.P292L|PRICKLE1_ENST00000345127.3_Missense_Mutation_p.P292L|RP11-328C8.4_ENST00000547824.1_RNA|PRICKLE1_ENST00000548696.1_Missense_Mutation_p.P292L|PRICKLE1_ENST00000552240.1_Missense_Mutation_p.P292L	NM_001144882.1|NM_001144883.1	NP_001138354.1|NP_001138355.1	Q96MT3	PRIC1_HUMAN	prickle homolog 1 (Drosophila)	292	LIM zinc-binding 3.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(13)|ovary(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	47	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		GGGAAGGAAGGGACATCCCAA	0.522000													51	36					0	0	1	0	0
ZFP28	140612	broad.mit.edu	37	19	57061948	57061948	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:57061948G>A	ENST00000301318.3	+	7	943	c.872G>A	c.(871-873)cGa>cAa	p.R291Q	AC007228.11_ENST00000596587.1_RNA|ZFP28_ENST00000591844.1_Missense_Mutation_p.R291Q	NM_020828.1	NP_065879.1	Q8NHY6	ZFP28_HUMAN	ZFP28 zinc finger protein	291	KRAB 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(14)|lung(6)|ovary(1)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	35		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0302)		ATGGTGAAGCGAGAGCTGACA	0.493000													22	16					0	0	1	0	0
MTNR1A	4543	broad.mit.edu	37	4	187455635	187455635	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr4:187455635C>T	ENST00000307161.5	-	2	462	c.261G>A	c.(259-261)tcG>tcA	p.S87S	RP11-215A19.2_ENST00000509111.1_Intron	NM_005958.3	NP_005949.1	P48039	MTR1A_HUMAN	melatonin receptor 1A	87					circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	14		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	TGTTAAATATCGACATCAGCA	0.507000													25	32					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176759002	176759002	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:176759002T>G	ENST00000367662.3	+	18	5937	c.4773T>G	c.(4771-4773)atT>atG	p.I1591M		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1591	Sushi 3.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GCAGCTGCATTCCTGTGGTGT	0.473000													30	47					0	0	1	0	0
OR1N1	138883	broad.mit.edu	37	9	125289392	125289392	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr9:125289392A>T	ENST00000304880.2	-	1	180	c.181T>A	c.(181-183)Ttg>Atg	p.L61M		NM_012363.1	NP_036495.1	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N, member 1	61					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|large_intestine(2)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						AGGTTGGCCAAGAAAAAGTAC	0.483000													31	12					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24884798	24884798	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr14:24884798G>A	ENST00000382554.3	+	9	4161	c.3843G>A	c.(3841-3843)gaG>gaA	p.E1281E		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1281					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						TGCTGGGGGAGAACCGCCTGC	0.617000													51	89					0	0	1	0	0
RAB3IP	117177	broad.mit.edu	37	12	70188971	70188971	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:70188971C>T	ENST00000550536.1	+	6	1240	c.783C>T	c.(781-783)tcC>tcT	p.S261S	RAB3IP_ENST00000325555.9_Silent_p.S39S|RAB3IP_ENST00000362025.5_Silent_p.S261S|RAB3IP_ENST00000553099.1_Silent_p.S39S|RAB3IP_ENST00000378815.6_Silent_p.S245S|RAB3IP_ENST00000483530.2_Silent_p.S245S|RAB3IP_ENST00000551641.1_Silent_p.S39S|RAB3IP_ENST00000247833.7_Silent_p.S245S	NM_001278402.1|NM_175623.2	NP_001265331.1|NP_783322.1	Q96QF0	RAB3I_HUMAN	RAB3A interacting protein	261					cilium assembly|Golgi to plasma membrane transport|protein localization to organelle|protein transport	actin cortical patch|centrosome|cytosol|lamellipodium|microtubule basal body|nucleus	guanyl-nucleotide exchange factor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	22	Esophageal squamous(21;0.187)		Lung(24;0.000381)|OV - Ovarian serous cystadenocarcinoma(12;0.00168)|STAD - Stomach adenocarcinoma(21;0.00694)			TTGTATTGTCCAGTTCTCCAA	0.398000													64	41					0	0	1	0	0
HBB	3043	broad.mit.edu	37	11	5247807	5247807	+	Splice_Site	SNP	C	C	T	rs33914944		TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:5247807C>T	ENST00000335295.3	-	2	490	c.315_splice	c.e2+1	p.R105_splice		NM_000518.4	NP_000509.1	P68871	HBB_HUMAN	hemoglobin, beta	105			R -> S (in Camperdown and Duino; associated with P-92 in Duino; unstable).|R -> T (in Sherwood Forest).		blood coagulation|hydrogen peroxide catabolic process|nitric oxide transport|positive regulation of cell death|positive regulation of nitric oxide biosynthetic process|protein heterooligomerization|regulation of blood pressure|regulation of blood vessel size	haptoglobin-hemoglobin complex|hemoglobin complex	heme binding|hemoglobin binding|oxygen binding|oxygen transporter activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|skin(1)	15		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)	Iron Dextran(DB00893)	ATAGACTCACCCTGAAGTTCT	0.483000									Sickle Cell Trait				26	46					0	0	1	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102304772	102304772	+	RNA	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr15:102304772T>C	ENST00000561463.1	+	0	12818																											CACAGCGGCGTGACGAGACTC	0.587000													6	25					0	0	1	0	0
C22orf43	51233	broad.mit.edu	37	22	23967085	23967085	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr22:23967085G>A	ENST00000317749.5	-	3	580	c.283C>T	c.(283-285)Cca>Tca	p.P95S		NM_016449.3	NP_057533.2	Q6PGQ1	CV043_HUMAN	chromosome 22 open reading frame 43	95										endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)|skin(1)	11						ACAGGTGATGGTAAAATCTGC	0.383000													69	114					0	0	1	0	0
ZFP69B	65243	broad.mit.edu	37	1	40928119	40928119	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:40928119G>A	ENST00000411995.2	+	6	838	c.463G>A	c.(463-465)Gag>Aag	p.E155K	ZFP69B_ENST00000484445.1_Missense_Mutation_p.R126K|ZFP69B_ENST00000361584.3_Missense_Mutation_p.E53K	NM_023070.2	NP_075558.2			ZFP69 zinc finger protein B																		AAAAACCAAAGAGTCAGCCTT	0.353000													44	91					0	0	1	0	0
C4orf46	201725	broad.mit.edu	37	4	159590801	159590801	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr4:159590801C>T	ENST00000379205.4	-	2	550	c.306G>A	c.(304-306)ttG>ttA	p.L102L	C4orf46_ENST00000508457.1_3'UTR|C4orf46_ENST00000508836.1_5'UTR	NM_001008393.2	NP_001008394.1	Q504U0	CD046_HUMAN	chromosome 4 open reading frame 46	102										kidney(1)|lung(3)|skin(1)	5						AGCCTTCTTTCAAGAGGTCCC	0.373000													17	30					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75038084	75038084	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:75038084C>T	ENST00000326665.5	-	14	3528	c.3310G>A	c.(3310-3312)Gaa>Aaa	p.E1104K	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1104	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						GTCTCTGTTTCCCCTTCTTCC	0.453000													47	76					0	0	1	0	0
ZNF324B	388569	broad.mit.edu	37	19	58965615	58965615	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:58965615C>T	ENST00000336614.4	+	3	249	c.142C>T	c.(142-144)Cgt>Tgt	p.R48C	ZNF324B_ENST00000391696.1_5'UTR|ZNF324B_ENST00000545523.1_Missense_Mutation_p.R48C|ZNF324B_ENST00000594214.1_Missense_Mutation_p.R48C	NM_207395.2	NP_997278.2	Q6AW86	Z324B_HUMAN	zinc finger protein 324B	48	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R48C(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		CTCCCGACCTCGTGTGGTCAT	0.602000													24	6					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113312238	113312238	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr9:113312238C>T	ENST00000401783.2	-	2	1014	c.678G>A	c.(676-678)ggG>ggA	p.G226G	SVEP1_ENST00000467821.1_5'UTR|SVEP1_ENST00000302728.8_Silent_p.G226G|SVEP1_ENST00000374469.1_Silent_p.G203G|SVEP1_ENST00000374461.1_Silent_p.G203G	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	226	VWFA.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CTCGAATGTTCCCTTGCCATA	0.493000													15	13					0	0	1	0	0
HPGDS	27306	broad.mit.edu	37	4	95239110	95239110	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr4:95239110G>A	ENST00000295256.5	-	3	230	c.140C>T	c.(139-141)cCa>cTa	p.P47L	HPGDS_ENST00000514774.1_5'UTR	NM_014485.2	NP_055300.1	O60760	HPGDS_HUMAN	hematopoietic prostaglandin D synthase	47	GST N-terminal.				locomotory behavior|prostaglandin biosynthetic process|signal transduction	cytoplasm|nucleus	calcium ion binding|glutathione transferase activity|magnesium ion binding|prostaglandin-D synthase activity|protein homodimerization activity			breast(1)|cervix(1)|lung(3)|ovary(1)|urinary_tract(1)	7					Glutathione(DB00143)	TTTTCCAAATGGGAGAGCTTA	0.328000													14	26					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31895859	31895859	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr6:31895859C>T	ENST00000556679.1	+	2	229	c.174C>T	c.(172-174)tcC>tcT	p.S58S	C2_ENST00000442278.2_Intron|C2_ENST00000469372.1_Intron|C2_ENST00000418949.2_Silent_p.S58S|C2_ENST00000452323.2_Intron|CFB_ENST00000477310.1_Silent_p.S58S|CFB_ENST00000456570.1_Silent_p.S58S|C2_ENST00000299367.5_Silent_p.S58S			P00751	CFAB_HUMAN	complement factor B	69	Sushi 1.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						TGTACCCATCCCCAGCATCAC	0.637000													14	20					0	0	1	0	0
MUC3A	4584	broad.mit.edu	37	7	100551652	100551652	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:100551652C>T	ENST00000319509.7	+	1	403	c.403C>T	c.(403-405)Cct>Tct	p.P135S						mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						ACAGACCCCTCCTGTACTGAC	0.483000													198	355					0	0	1	0	0
POM121	9883	broad.mit.edu	37	7	72413525	72413525	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:72413525G>A	ENST00000395270.1	+	14	3239	c.2198G>A	c.(2197-2199)gGa>gAa	p.G733E	POM121_ENST00000358357.3_Missense_Mutation_p.G733E|POM121_ENST00000257622.4_Missense_Mutation_p.G733E|POM121_ENST00000434423.2_Missense_Mutation_p.G998E|POM121_ENST00000446813.1_Missense_Mutation_p.G733E	NM_001257190.1	NP_001244119.1	Q96HA1	P121A_HUMAN	POM121 transmembrane nucleoporin	998	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|breast(1)|endometrium(9)|kidney(4)|large_intestine(6)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Lung NSC(55;0.163)				TTCACTTTTGGAAACTCTGCA	0.657000													36	178					0	0	1	0	0
TIMELESS	8914	broad.mit.edu	37	12	56826249	56826249	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:56826249G>A	ENST00000229201.4	-	7	742	c.588C>T	c.(586-588)ggC>ggT	p.G196G	TIMELESS_ENST00000554616.1_Silent_p.G197G|TIMELESS_ENST00000553532.1_Silent_p.G197G	NM_003920.3	NP_003911.2	Q9UNS1	TIM_HUMAN	timeless circadian clock	197					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				NS(1)|breast(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(8)|lung(14)|ovary(7)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	49						GGTCATCCAGGCCGCTGAGGT	0.537000													39	70					0	0	1	0	0
CD5L	922	broad.mit.edu	37	1	157803152	157803152	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:157803152G>A	ENST00000368174.4	-	5	965	c.869C>T	c.(868-870)tCc>tTc	p.S290F		NM_005894.2	NP_005885.1	O43866	CD5L_HUMAN	CD5 molecule-like	290	SRCR 3.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	52	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GGGAGAGAGGGACTTCCCACA	0.587000													49	83					0	0	1	0	0
C17orf80	55028	broad.mit.edu	37	17	71232534	71232534	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:71232534G>A	ENST00000359042.2	+	3	1107	c.913G>A	c.(913-915)Gag>Aag	p.E305K	C17orf80_ENST00000577615.1_Missense_Mutation_p.E305K|C17orf80_ENST00000255557.4_Missense_Mutation_p.E305K|C17orf80_ENST00000426147.2_Missense_Mutation_p.E305K|C17orf80_ENST00000582793.1_Intron|FAM104A_ENST00000583178.1_Intron|C17orf80_ENST00000268942.8_Missense_Mutation_p.E305K|C17orf80_ENST00000535032.2_Missense_Mutation_p.E305K	NM_017941.4	NP_060411.2	Q9BSJ5	CQ080_HUMAN	chromosome 17 open reading frame 80	305						integral to membrane				kidney(1)|large_intestine(5)|lung(2)|skin(2)|stomach(2)|urinary_tract(2)	14			LUSC - Lung squamous cell carcinoma(166;0.197)			CCTGGGAGTAGAGACGTGTGG	0.433000													21	30					0	0	1	0	0
NTPCR	84284	broad.mit.edu	37	1	233086482	233086482	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:233086482G>A	ENST00000366627.4	+	1	97	c.26G>A	c.(25-27)gGg>gAg	p.G9E	NTPCR_ENST00000366628.4_Missense_Mutation_p.G9E			Q9BSD7	NTPCR_HUMAN	nucleoside-triphosphatase, cancer-related	9							ATP binding|nucleoside-triphosphatase activity|nucleotide phosphatase activity|transferase activity			large_intestine(2)|lung(1)|ovary(1)	4						TTCCTAACGGGGCCCCCAGGT	0.701000													15	28					0	0	1	0	0
FBXO21	23014	broad.mit.edu	37	12	117628131	117628131	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:117628131C>T	ENST00000427718.2	-	1	205	c.131G>A	c.(130-132)tGc>tAc	p.C44Y	FBXO21_ENST00000330622.5_Missense_Mutation_p.C44Y	NM_015002.2|NM_033624.2	NP_055817.1|NP_296373.1	O94952	FBX21_HUMAN	F-box protein 21	44	F-box.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			breast(4)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|pancreas(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	29	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		CAGCGAGCCGCAGCACAGGAT	0.711000													15	10					0	0	1	0	0
OR13C3	138803	broad.mit.edu	37	9	107298302	107298302	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr9:107298302G>A	ENST00000374781.2	-	1	835	c.793C>T	c.(793-795)Cgc>Tgc	p.R265C		NM_001001961.1	NP_001001961.1	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C, member 3	265					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(1)|skin(1)	19						AATGCCTTGCGTCTTCCTGTG	0.428000													45	23					0	0	1	0	0
LRRC37B	114659	broad.mit.edu	37	17	30376284	30376284	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:30376284G>A	ENST00000327564.7	+	10	2689	c.2628G>A	c.(2626-2628)ctG>ctA	p.L876L	LRRC37B_ENST00000543378.2_Silent_p.L767L|LRRC37B_ENST00000394713.3_Silent_p.L798L|LRRC37B_ENST00000584368.1_Silent_p.L810L|LRRC37B_ENST00000341671.7_Silent_p.L849L			Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B	849						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	29		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				CAGGCCTCCTGATGAAGCTTC	0.433000													25	39					0	0	1	0	0
PPL	5493	broad.mit.edu	37	16	4934359	4934359	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:4934359C>A	ENST00000345988.2	-	22	4386	c.4297G>T	c.(4297-4299)Gaa>Taa	p.E1433*	PPL_ENST00000590782.2_Nonsense_Mutation_p.E1431*	NM_002705.4	NP_002696.3	O60437	PEPL_HUMAN	periplakin	1433					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						TCAGCTTCTTCCTGCTCCAGC	0.682000													69	96					9.35569e-46	9.6221e-46	1	1	0
NRIP1	8204	broad.mit.edu	37	21	16338386	16338386	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr21:16338386G>A	ENST00000400202.1	-	3	2840	c.2128C>T	c.(2128-2130)Cgt>Tgt	p.R710C	NRIP1_ENST00000400199.1_Missense_Mutation_p.R710C|NRIP1_ENST00000318948.4_Missense_Mutation_p.R710C			P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	710					androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity			cervix(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(13)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	39				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		AGGACAGTACGTCTTTCAAGC	0.408000													9	14					0	0	1	0	0
RAB3IP	117177	broad.mit.edu	37	12	70149365	70149365	+	Translation_Start_Site	SNP	T	T	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:70149365T>G	ENST00000325555.9	+	0	372				RAB3IP_ENST00000362025.5_Missense_Mutation_p.D75E|RAB3IP_ENST00000378815.6_Missense_Mutation_p.D59E|RAB3IP_ENST00000550536.1_Missense_Mutation_p.D75E|RAB3IP_ENST00000483530.2_Missense_Mutation_p.D59E|RAB3IP_ENST00000247833.7_Missense_Mutation_p.D59E	NM_022456.3	NP_071901.2	Q96QF0	RAB3I_HUMAN	RAB3A interacting protein						cilium assembly|Golgi to plasma membrane transport|protein localization to organelle|protein transport	actin cortical patch|centrosome|cytosol|lamellipodium|microtubule basal body|nucleus	guanyl-nucleotide exchange factor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	22	Esophageal squamous(21;0.187)		Lung(24;0.000381)|OV - Ovarian serous cystadenocarcinoma(12;0.00168)|STAD - Stomach adenocarcinoma(21;0.00694)			ATGCATTAGATGTTTCTGAAC	0.418000													31	115					0	0	1	0	0
MAP3K6	9064	broad.mit.edu	37	1	27683182	27683182	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:27683182G>A	ENST00000374040.3	-	24	3659	c.3399C>T	c.(3397-3399)tcC>tcT	p.S1133S	MAP3K6_ENST00000493901.1_Silent_p.S1141S|MAP3K6_ENST00000357582.2_Silent_p.S1141S			O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase 6	1141					activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|central_nervous_system(2)|lung(3)|ovary(1)	10		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GGCTCTGCTGGGAGTCCCCTT	0.647000													20	30					0	0	1	0	0
CROCCP2	84809	broad.mit.edu	37	1	16946323	16946323	+	RNA	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:16946323C>T	ENST00000412962.1	-	0	1196																											GCAGAGGCCACGCCAGGGCTC	0.662000													3	10					0	0	1	0	0
PADI4	23569	broad.mit.edu	37	1	17674526	17674526	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:17674526C>T	ENST00000375448.4	+	10	1164	c.1138C>T	c.(1138-1140)Ccc>Tcc	p.P380S	PADI4_ENST00000487048.1_3'UTR|AC004824.2_ENST00000602074.1_Intron	NM_012387.2	NP_036519.2	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	380					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(2)|urinary_tract(3)	26		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	GAAGGAGTTTCCCATCAAACG	0.577000													18	41					0	0	1	0	0
CD248	57124	broad.mit.edu	37	11	66083748	66083748	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:66083748C>T	ENST00000311330.3	-	1	767	c.751G>A	c.(751-753)Gat>Aat	p.D251N	RP11-867G23.13_ENST00000534065.1_RNA	NM_020404.2	NP_065137.1	Q9HCU0	CD248_HUMAN	CD248 molecule, endosialin	251						integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	26					Cefalotin(DB00456)	ACGTGACCATCCACCTCCTCC	0.687000													26	36					0	0	1	0	0
CNN1	1264	broad.mit.edu	37	19	11660173	11660173	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:11660173G>A	ENST00000592923.1	+	7	964	c.387G>A	c.(385-387)atG>atA	p.M129I	CNN1_ENST00000252456.2_Missense_Mutation_p.M179I|CNN1_ENST00000535659.2_Missense_Mutation_p.M129I|CNN1_ENST00000544952.1_Missense_Mutation_p.M159I			P51911	CNN1_HUMAN	calponin 1, basic, smooth muscle	179	CH.				actomyosin structure organization|regulation of smooth muscle contraction	cytoskeleton	actin binding|calmodulin binding			breast(1)|endometrium(2)|large_intestine(4)|lung(2)	9						AGCAGGGCATGACGGCCTATG	0.582000													31	55					0	0	1	0	0
APOBR	55911	broad.mit.edu	37	16	28509528	28509528	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:28509528G>A	ENST00000564831.1	+	3	3115	c.3082G>A	c.(3082-3084)Gag>Aag	p.E1028K	APOBR_ENST00000431282.1_Missense_Mutation_p.E1019K|APOBR_ENST00000328423.5_Missense_Mutation_p.E1019K	NM_018690.3	NP_061160.3	Q0VD83	APOBR_HUMAN	apolipoprotein B receptor	1019					cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|skin(2)|stomach(1)	29						GCAGCAGGAGGAGCCCCCAGC	0.662000													9	9					0	0	1	0	0
NUF2	83540	broad.mit.edu	37	1	163307814	163307814	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:163307814C>T	ENST00000271452.3	+	7	719	c.440C>T	c.(439-441)tCc>tTc	p.S147F	NUF2_ENST00000490881.1_3'UTR|NUF2_ENST00000524800.1_Missense_Mutation_p.S147F|NUF2_ENST00000367900.3_Missense_Mutation_p.S147F	NM_145697.2	NP_663735.2	Q9BZD4	NUF2_HUMAN	NUF2, NDC80 kinetochore complex component	147	Interaction with the N-terminus of NDC80.				cell division|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(15)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35	all_hematologic(923;0.101)					TAATAGAAATCCTCTGCGGAC	0.353000													20	41					0	0	1	0	0
AOC4P	90586	broad.mit.edu	37	17	41020789	41020789	+	RNA	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:41020789C>T	ENST00000585538.1	+	0	1628					NR_002773.1																						GCTCAGCATTCCCCTTTGGTG	0.532000													8	16					0	0	1	0	0
ZNF12	7559	broad.mit.edu	37	7	6730689	6730689	+	Silent	SNP	T	T	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:6730689T>A	ENST00000405858.1	-	5	2425	c.1884A>T	c.(1882-1884)tcA>tcT	p.S628S	ZNF12_ENST00000342651.5_Silent_p.S590S|AC073343.13_ENST00000366167.2_RNA|ZNF12_ENST00000404360.1_Silent_p.S554S	NM_006956.2|NM_016265.3	NP_008887.2|NP_057349.2	P17014	ZNF12_HUMAN	zinc finger protein 12	628					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|endometrium(1)|large_intestine(1)|lung(7)|prostate(2)|upper_aerodigestive_tract(3)	16		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		GTTTCTCTCCTGAATGAATTC	0.413000													21	37					0	0	1	0	0
JUP	3728	broad.mit.edu	37	17	39925852	39925852	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:39925852C>A	ENST00000393931.3	-	3	404	c.286G>T	c.(286-288)Gag>Tag	p.E96*	JUP_ENST00000393930.1_Nonsense_Mutation_p.E96*|JUP_ENST00000310706.5_Nonsense_Mutation_p.E96*|JUP_ENST00000540235.1_Nonsense_Mutation_p.E96*	NM_002230.2	NP_002221.1	P14923	PLAK_HUMAN	junction plakoglobin	96					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	23		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		GAGCTGTCCTCGCCTGACACA	0.662000													7	9					2.0095e-06	2.02267e-06	1	1	0
NCKAP1L	3071	broad.mit.edu	37	12	54917264	54917264	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:54917264G>A	ENST00000293373.6	+	19	2044	c.1965G>A	c.(1963-1965)gaG>gaA	p.E655E	NCKAP1L_ENST00000545638.2_Silent_p.E605E	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	655					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						GAAAAGGAGAGCCCGAGAGGG	0.537000													53	90					0	0	1	0	0
ADAM7	8756	broad.mit.edu	37	8	24324436	24324436	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr8:24324436G>A	ENST00000175238.6	+	6	597	c.514G>A	c.(514-516)Gag>Aag	p.E172K	RP11-624C23.1_ENST00000519689.1_RNA|ADAM7_ENST00000380789.1_Missense_Mutation_p.E172K|ADAM7_ENST00000441335.2_Missense_Mutation_p.E172K|RP11-624C23.1_ENST00000523578.1_RNA	NM_003817.3	NP_003808.2	Q9H2U9	ADAM7_HUMAN	ADAM metallopeptidase domain 7	172					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(24)|ovary(1)|skin(15)	64		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		TTCCTGTACAGAGCTTAATTT	0.363000													46	63					0	0	1	0	0
NSUN7	79730	broad.mit.edu	37	4	40776902	40776902	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr4:40776902C>T	ENST00000381782.2	+	6	1255	c.760C>T	c.(760-762)Cca>Tca	p.P254S	NSUN7_ENST00000316607.5_Missense_Mutation_p.P254S|NSUN7_ENST00000463952.1_3'UTR	NM_024677.4	NP_078953.3			NOP2/Sun domain family, member 7											NS(1)|autonomic_ganglia(1)|cervix(1)|large_intestine(1)|lung(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	12						CTTAATTTTTCCATCTCATCT	0.264000													12	21					0	0	1	0	0
OR10G2	26534	broad.mit.edu	37	14	22102462	22102462	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr14:22102462C>T	ENST00000542433.1	-	1	634	c.537G>A	c.(535-537)gtG>gtA	p.V179V		NM_001005466.1	NP_001005466.1	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G, member 2	179					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(2)	22	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		TAAAGTAATCCACCTGATTGG	0.572000													59	106					0	0	1	0	0
PHF7	51533	broad.mit.edu	37	3	52454956	52454956	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:52454956C>T	ENST00000327906.3	+	7	1111	c.451C>T	c.(451-453)Caa>Taa	p.Q151*	PHF7_ENST00000347025.2_Nonsense_Mutation_p.Q151*|PHF7_ENST00000478707.1_Nonsense_Mutation_p.Q151*	NM_016483.4	NP_057567.3	Q9BWX1	PHF7_HUMAN	PHD finger protein 7	151						nucleus	zinc ion binding			breast(2)|large_intestine(4)|lung(3)	9				BRCA - Breast invasive adenocarcinoma(193;1.71e-05)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)|OV - Ovarian serous cystadenocarcinoma(275;0.0275)		ACAGAACATCCAACATGGGCA	0.468000													65	30					0	0	1	0	0
BCL2	596	broad.mit.edu	37	18	60985872	60985872	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr18:60985872C>T	ENST00000398117.1	-	1	1489	c.28G>A	c.(28-30)Gat>Aat	p.D10N	BCL2_ENST00000333681.4_Missense_Mutation_p.D10N|BCL2_ENST00000589955.1_Missense_Mutation_p.D10N|BCL2_ENST00000444484.1_Missense_Mutation_p.D10N	NM_000633.2	NP_000624.2	P10415	BCL2_HUMAN	B-cell CLL/lymphoma 2	10					activation of pro-apoptotic gene products|anti-apoptosis|apoptosis in response to endoplasmic reticulum stress|B cell proliferation|B cell receptor signaling pathway|defense response to virus|female pregnancy|humoral immune response|induction of apoptosis by intracellular signals|negative regulation of cellular pH reduction|negative regulation of mitochondrial depolarization|negative regulation of neuron apoptosis|neuron apoptosis|positive regulation of B cell proliferation|positive regulation of cell growth|protein polyubiquitination|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|regulation of transmembrane transporter activity|release of cytochrome c from mitochondria|response to cytokine stimulus|response to DNA damage stimulus|response to drug|response to iron ion|response to nicotine|response to toxin	endoplasmic reticulum membrane|mitochondrial outer membrane|nuclear membrane|pore complex	BH3 domain binding|channel activity|protease binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(106)|kidney(1)|large_intestine(1)|lung(3)	113		all_hematologic(56;1.18e-20)|Prostate(75;0.0872)		Lung(128;0.0234)|READ - Rectum adenocarcinoma(59;0.0935)	Docetaxel(DB01248)|Fludarabine(DB01073)|Melatonin(DB01065)|Paclitaxel(DB01229)|Rasagiline(DB01367)	TCCCGGTTATCGTACCCTGTT	0.647000			T	IGH@	"""NHL, CLL"""								68	106					0	0	1	0	0
SEL1L2	80343	broad.mit.edu	37	20	13830214	13830214	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr20:13830214T>G	ENST00000284951.5	-	20	2058	c.1984A>C	c.(1984-1986)Acc>Ccc	p.T662P	SEL1L2_ENST00000378072.5_Missense_Mutation_p.T549P|SEL1L2_ENST00000486903.1_5'UTR			Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 (C. elegans)	662						integral to membrane	binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	51						GGTCCAATGGTGTTGTCCAGT	0.478000													28	45					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	134108454	134108454	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr8:134108454T>G	ENST00000220616.4	+	43	7449	c.7409T>G	c.(7408-7410)cTg>cGg	p.L2470R	SLA_ENST00000338087.5_Intron|TG_ENST00000542445.1_Missense_Mutation_p.L840R|SLA_ENST00000518565.1_Intron|TG_ENST00000377869.1_Missense_Mutation_p.L2413R|SLA_ENST00000524345.1_Intron|SLA_ENST00000517648.1_Intron|SLA_ENST00000395352.3_Intron|TG_ENST00000519543.1_Missense_Mutation_p.L603R	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2470					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		ATGCAGCTCCTGGCCGTGAGT	0.498000													82	120					0	0	1	0	0
FAM208A	23272	broad.mit.edu	37	3	56667652	56667652	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:56667652T>C	ENST00000431842.2	-	11	2780	c.1856A>G	c.(1855-1857)gAg>gGg	p.E619G	FAM208A_ENST00000493960.2_Missense_Mutation_p.E1056G|FAM208A_ENST00000355628.5_Missense_Mutation_p.E995G	NM_015224.3	NP_056039.2	Q9UK61	CC063_HUMAN	family with sequence similarity 208, member A	1056										NS(1)|breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(11)|prostate(3)|skin(1)	32						TTTCATCTTCTCTTGTGTTGA	0.363000													8	46					0	0	1	0	0
OPRK1	4986	broad.mit.edu	37	8	54142250	54142250	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr8:54142250G>A	ENST00000265572.3	-	4	1047	c.750C>T	c.(748-750)atC>atT	p.I250I	OPRK1_ENST00000520287.1_Silent_p.I250I|OPRK1_ENST00000524278.1_Silent_p.I161I|RP11-162D9.3_ENST00000524425.1_RNA	NM_000912.3	NP_000903.2	P41145	OPRK_HUMAN	opioid receptor, kappa 1	250					behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			NS(2)|breast(3)|endometrium(3)|kidney(12)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	43		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	TGAGACGCAGGATCATCAGGG	0.547000													21	46					0	0	1	0	0
UROC1	131669	broad.mit.edu	37	3	126220131	126220131	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:126220131G>A	ENST00000383579.3	-	11	1108	c.1075C>T	c.(1075-1077)Cct>Tct	p.P359S	UROC1_ENST00000290868.2_Intron	NM_001165974.1	NP_001159446.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1	0					histidine catabolic process	cytosol	urocanate hydratase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(1)|skin(1)	39				GBM - Glioblastoma multiforme(114;0.17)		TCCCTGGAAGGACACAAAAGC	0.592000													67	112					0	0	1	0	0
ATP8A1	10396	broad.mit.edu	37	4	42454043	42454043	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr4:42454043G>A	ENST00000381668.5	-	30	3082	c.2851C>T	c.(2851-2853)Cac>Tac	p.H951Y	ATP8A1_ENST00000264449.10_Missense_Mutation_p.H936Y	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	951					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	ATAACTGAGTGGAAGAGGCCA	0.363000													12	16					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140474984	140474984	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:140474984C>T	ENST00000194155.4	+	1	758	c.610C>T	c.(610-612)Cgc>Tgc	p.R204C		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		204	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCCCTGGATCGCGAGGAGCA	0.507000													6	10					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34049385	34049385	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:34049385A>C	ENST00000373381.4	-	47	7273	c.7097T>G	c.(7096-7098)aTc>aGc	p.I2366S		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2368	CUB 14.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CTGGCTCAGGATCACGCCTGT	0.537000													19	43					0	0	1	0	0
L3MBTL1	26013	broad.mit.edu	37	20	42161441	42161441	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr20:42161441G>A	ENST00000444063.1	+	9	1175	c.1043G>A	c.(1042-1044)gGc>gAc	p.G348D	L3MBTL1_ENST00000418998.1_Missense_Mutation_p.G416D|L3MBTL1_ENST00000373135.3_Missense_Mutation_p.G348D|L3MBTL1_ENST00000373134.1_Missense_Mutation_p.G348D|L3MBTL1_ENST00000427442.2_Missense_Mutation_p.G416D			Q9Y468	LMBL1_HUMAN	l(3)mbt-like 1 (Drosophila)	348					chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|large_intestine(3)|ovary(1)|skin(2)	7						TTCCAGGTGGGCATGAAGCTG	0.612000													69	78					0	0	1	0	0
ISM2	145501	broad.mit.edu	37	14	77948812	77948812	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr14:77948812G>A	ENST00000393684.3	-	5	953	c.562C>T	c.(562-564)Cct>Tct	p.P188S	ISM2_ENST00000342219.4_Missense_Mutation_p.P276S|ISM2_ENST00000493585.1_Intron|ISM2_ENST00000429906.1_Missense_Mutation_p.P195S|ISM2_ENST00000412904.1_Missense_Mutation_p.P195S			Q6H9L7	ISM2_HUMAN	isthmin 2	276						extracellular region				endometrium(3)|large_intestine(4)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	21						tcctctgaaggatagtcctcg	0.557000													19	34					0	0	1	0	0
ZNF585A	199704	broad.mit.edu	37	19	37644152	37644152	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:37644152T>A	ENST00000356958.4	-	5	907	c.649A>T	c.(649-651)Agc>Tgc	p.S217C	ZNF585A_ENST00000588723.1_Intron|ZNF585A_ENST00000355533.2_Missense_Mutation_p.S162C|ZNF585A_ENST00000292841.5_Missense_Mutation_p.S162C|ZNF585A_ENST00000392157.2_Missense_Mutation_p.S162C			Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	217					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(2)|large_intestine(17)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CCACACTGGCTGCATTCATAG	0.418000													30	38					0	0	1	0	0
MDGA1	266727	broad.mit.edu	37	6	37606051	37606051	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr6:37606051C>T	ENST00000434837.2	-	16	3884	c.2706G>A	c.(2704-2706)ggG>ggA	p.G902G	MDGA1_ENST00000297153.7_Silent_p.G906G|MDGA1_ENST00000505425.1_Silent_p.G902G	NM_153487.3	NP_705691.1	Q8NFP4	MDGA1_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 1	902	MAM.				brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	38						TGGCAATATCCCCCAGGTAGC	0.577000													31	38					0	0	1	0	0
GABRA3	2556	broad.mit.edu	37	X	151514133	151514133	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chrX:151514133G>A	ENST00000370314.4	-	3	420	c.182C>T	c.(181-183)aCt>aTt	p.T61I	GABRA3_ENST00000535043.1_Missense_Mutation_p.T61I|GABRA3_ENST00000370311.1_Missense_Mutation_p.T61I	NM_000808.3	NP_000799.1	P34903	GBRA3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 3	61					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(6)	37	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GATGTTGTCAGTGCTGTCATC	0.428000													33	8					0	0	1	0	0
RGS9	8787	broad.mit.edu	37	17	63193346	63193346	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:63193346G>A	ENST00000449996.3	+	13	1026	c.954G>A	c.(952-954)aaG>aaA	p.K318K	RGS9_ENST00000262406.9_Silent_p.K321K|RGS9_ENST00000443584.3_Silent_p.K318K	NM_001081955.2	NP_001075424.1	O75916	RGS9_HUMAN	regulator of G-protein signaling 9	321	RGS.				intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(8)|liver(2)|lung(12)|ovary(2)|prostate(3)|skin(3)	41						ACTTCCTCAAGAAAGAATTCA	0.413000													13	18					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34123663	34123663	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:34123663C>T	ENST00000373381.4	-	27	4506	c.4330G>A	c.(4330-4332)Ggc>Agc	p.G1444S	CSMD2_ENST00000373388.2_5'UTR|CSMD2_ENST00000373380.1_Missense_Mutation_p.G317S	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1404						integral to membrane|plasma membrane	protein binding	p.G1404S(1)		NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GTGGAGTCGCCGGCTTCCCAA	0.582000													42	74					0	0	1	0	0
DEPDC5	9681	broad.mit.edu	37	22	32275614	32275614	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr22:32275614C>T	ENST00000382105.2	+	35	3708	c.3566C>T	c.(3565-3567)tCg>tTg	p.S1189L	DEPDC5_ENST00000382111.2_Silent_p.L1303L|DEPDC5_ENST00000400248.1_Silent_p.L1272L|DEPDC5_ENST00000400249.2_Silent_p.L1272L|DEPDC5_ENST00000382112.3_Silent_p.L1294L|DEPDC5_ENST00000400246.1_Silent_p.L1303L|DEPDC5_ENST00000266091.3_Silent_p.L1281L|DEPDC5_ENST00000539165.1_Silent_p.L120L|DEPDC5_ENST00000535622.1_Silent_p.L1203L			O75140	DEPD5_HUMAN	DEP domain containing 5	0	DEP.				intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						CAGAAGAGCTCGTGCACTCTG	0.602000													44	52					0	0	1	0	0
AFG3L2	10939	broad.mit.edu	37	18	12348319	12348319	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr18:12348319G>A	ENST00000269143.3	-	13	1847	c.1616C>T	c.(1615-1617)tCc>tTc	p.S539F		NM_006796.2	NP_006787.2	Q9Y4W6	AFG32_HUMAN	AFG3-like AAA ATPase 2	539					cell death|protein catabolic process|proteolysis	integral to membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(12)|prostate(3)|skin(1)|stomach(3)|urinary_tract(1)	27					Adenosine triphosphate(DB00171)	CTGATTTATGGAATCTGACAG	0.398000													23	29					0	0	1	0	0
PCDH11Y	83259	broad.mit.edu	37	Y	4968154	4968154	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chrY:4968154C>T	ENST00000333703.4	+	5	3015	c.2502C>T	c.(2500-2502)atC>atT	p.I834I	PCDH11Y_ENST00000215473.6_Silent_p.I845I|PCDH11Y_ENST00000362095.5_Silent_p.I845I	NM_001278619.1|NM_032971.2	NP_001265548.1|NP_116753.1	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked	845					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			autonomic_ganglia(1)|kidney(2)|large_intestine(7)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						ATGTCAAGATCCTGGTTGCAG	0.463000													29	10					0	0	1	0	0
GPR149	344758	broad.mit.edu	37	3	154056036	154056036	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:154056036G>A	ENST00000389740.2	-	4	1747	c.1648C>T	c.(1648-1650)Ccc>Tcc	p.P550S		NM_001038705.1	NP_001033794.1	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	550						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(22)|ovary(7)|prostate(1)|skin(1)|urinary_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			GCACACAAGGGAATGGCAAGG	0.433000													54	93					0	0	1	0	0
ZNF212	7988	broad.mit.edu	37	7	148951243	148951243	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:148951243A>T	ENST00000335870.2	+	5	1353	c.1225A>T	c.(1225-1227)Aac>Tac	p.N409Y		NM_012256.3	NP_036388.2	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	409					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|ovary(1)|prostate(1)	9	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)			GTTCTCACCCAACAGCCTGGT	0.597000													15	19					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	166986934	166986934	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr4:166986934T>A	ENST00000061240.2	+	16	2754	c.2107T>A	c.(2107-2109)Tcc>Acc	p.S703T	TLL1_ENST00000507499.1_Missense_Mutation_p.S726T	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	703	CUB 3.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		AGTGATCACATCCCAGTTCAA	0.398000													32	32					0	0	1	0	0
AKR1D1	6718	broad.mit.edu	37	7	137761275	137761275	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:137761275G>A	ENST00000242375.3	+	1	53	c.11G>A	c.(10-12)aGt>aAt	p.S4N	AKR1D1_ENST00000432161.1_Missense_Mutation_p.S4N|AKR1D1_ENST00000411726.2_Missense_Mutation_p.S4N|AKR1D1_ENST00000468877.2_Intron	NM_005989.3	NP_005980.1	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	4					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(14)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	23						ATGGATCTCAGTGCTGCAAGT	0.448000													27	27					0	0	1	0	0
CLOCK	9575	broad.mit.edu	37	4	56308643	56308643	+	Silent	SNP	G	G	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr4:56308643G>T	ENST00000309964.4	-	20	2311	c.2061C>A	c.(2059-2061)acC>acA	p.T687T	CLOCK_ENST00000381322.1_Silent_p.T687T|CLOCK_ENST00000513440.1_Silent_p.T687T	NM_004898.3	NP_004889.1	O15516	CLOCK_HUMAN	clock circadian regulator	687					circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(8)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			CAGCACTCTGGGTGCTGTTTT	0.413000													31	49					1.36615e-20	1.3957e-20	1	1	0
GOPC	57120	broad.mit.edu	37	6	117890746	117890746	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr6:117890746G>A	ENST00000535237.1	-	7	1295	c.1066C>T	c.(1066-1068)Ctt>Ttt	p.L356F	GOPC_ENST00000052569.6_Missense_Mutation_p.L348F|GOPC_ENST00000467125.1_5'UTR|DCBLD1_ENST00000296955.8_Intron|GOPC_ENST00000368498.2_Missense_Mutation_p.L356F					golgi-associated PDZ and coiled-coil motif containing										GOPC/ROS1(14)	endometrium(1)|large_intestine(3)|lung(4)|ovary(1)	9		all_cancers(87;0.00844)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0363)|OV - Ovarian serous cystadenocarcinoma(136;0.0821)|all cancers(137;0.0976)		TGCTGAGAAAGAATAGTTACA	0.408000			O	ROS1	glioblastoma								25	20					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66873807	66873807	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:66873807C>T	ENST00000269080.2	-	31	4069	c.3932G>A	c.(3931-3933)gGg>gAg	p.G1311E	ABCA8_ENST00000586539.1_Missense_Mutation_p.G1351E|ABCA8_ENST00000430352.2_Missense_Mutation_p.G1351E	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	1311	ABC transporter 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					TCCACCGCTCCCTTTCAGTAG	0.552000													39	48					0	0	1	0	0
CDR1	1038	broad.mit.edu	37	X	139866322	139866322	+	Silent	SNP	C	C	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chrX:139866322C>A	ENST00000370532.2	-	1	401	c.210G>T	c.(208-210)tcG>tcT	p.S70S		NM_004065.2	NP_004056.2	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1, 34kDa	70	23 X 6 AA approximate repeats.							p.S70S(1)		breast(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(2)|skin(4)|urinary_tract(1)	25	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				CCATAGCTTCCGAAAAATCCA	0.458000													12	63					3.07112e-06	3.0862e-06	1	1	0
LILRB4	11006	broad.mit.edu	37	19	55175721	55175721	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:55175721G>A	ENST00000391736.1	+	6	755	c.440G>A	c.(439-441)cGg>cAg	p.R147Q	LILRB4_ENST00000391733.3_Missense_Mutation_p.R147Q|LILRB4_ENST00000430952.2_Missense_Mutation_p.R147Q|LILRB4_ENST00000391734.3_Missense_Mutation_p.R147Q|LILRB4_ENST00000270452.2_Missense_Mutation_p.R147Q	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	147	Ig-like C2-type 2.					integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		TGTCAGTCACGGAGCCCAATG	0.572000													33	52					0	0	1	0	0
MAZ	4150	broad.mit.edu	37	16	29818724	29818724	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:29818724G>A	ENST00000219782.6	+	2	724	c.618G>A	c.(616-618)cgG>cgA	p.R206R	AC009133.15_ENST00000566537.1_RNA|MAZ_ENST00000545521.1_Silent_p.R183R|MAZ_ENST00000562337.1_Intron|MAZ_ENST00000563402.1_Intron|MAZ_ENST00000322945.6_Silent_p.R206R|MAZ_ENST00000566906.2_Intron	NM_001042539.1	NP_001036004.1	P56270	MAZ_HUMAN	MYC-associated zinc finger protein (purine-binding transcription factor)	206					regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription|transcription initiation from RNA polymerase II promoter	nucleus	DNA binding|protein binding|RNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	10						ACAATCTCCGGAGGCACGAAG	0.642000													19	26					0	0	1	0	0
NRG1	3084	broad.mit.edu	37	8	32463201	32463201	+	Splice_Site	SNP	G	G	A	rs78513616		TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr8:32463201G>A	ENST00000341377.5	+	3	917	c.400_splice	c.e3+1	p.E134_splice	NRG1_ENST00000287845.5_Splice_Site_p.A134_splice|NRG1_ENST00000405005.2_Splice_Site_p.E134_splice|NRG1_ENST00000287840.5_Splice_Site_p.E134_splice|NRG1_ENST00000519301.1_Splice_Site_p.A113_splice|NRG1_ENST00000338921.4_Splice_Site_p.E134_splice|NRG1_ENST00000521670.1_Splice_Site_p.E134_splice|NRG1_ENST00000287842.3_Splice_Site_p.E134_splice|NRG1_ENST00000523079.1_Splice_Site_p.E134_splice|NRG1_ENST00000356819.4_Splice_Site_p.E134_splice|NRG1_ENST00000520407.1_Splice_Site_p.A349_splice			Q02297	NRG1_HUMAN	neuregulin 1	134					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(1)|skin(1)	39		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		GGAATCAAACGGTAAGAGATA	0.398000													30	55					0	0	1	0	0
TAS2R60	338398	broad.mit.edu	37	7	143141462	143141462	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:143141462T>G	ENST00000332690.1	+	1	917	c.917T>G	c.(916-918)gTg>gGg	p.V306G	EPHA1-AS1_ENST00000429289.1_RNA	NM_177437.1	NP_803186.1	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	306					sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			breast(1)|kidney(1)|large_intestine(2)|lung(17)|prostate(1)|skin(7)|urinary_tract(2)	31	Melanoma(164;0.172)					CTGAGAGCTGTGCTGAAGAGT	0.498000													37	85					0	0	1	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42436185	42436185	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr15:42436185G>A	ENST00000397272.3	-	18	2230	c.2139C>T	c.(2137-2139)gcC>gcT	p.A713A	PLA2G4F_ENST00000382396.4_Silent_p.A711A	NM_213600.3	NP_998765.3	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	711	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		CCTCAAAAGGGGCTTCCAAGG	0.577000													39	94					0	0	1	0	0
THBS1	7057	broad.mit.edu	37	15	39877722	39877722	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr15:39877722A>G	ENST00000260356.5	+	7	1243	c.1078A>G	c.(1078-1080)Aat>Gat	p.N360D		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	360	VWFC.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	GCCCTGCTCCAATGCCACAGT	0.498000													29	52					0	0	1	0	0
HOMER2	9455	broad.mit.edu	37	15	83561518	83561518	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr15:83561518C>T	ENST00000304231.8	-	2	273	c.81G>A	c.(79-81)gcG>gcA	p.A27A	HOMER2_ENST00000399166.2_Silent_p.A27A|HOMER2_ENST00000426485.1_Silent_p.A27A|HOMER2_ENST00000450735.2_Silent_p.A27A	NM_199330.2	NP_955362.1	Q9NSB8	HOME2_HUMAN	homer homolog 2 (Drosophila)	27	WH1.				metabotropic glutamate receptor signaling pathway	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane		p.A27A(1)|p.A90A(1)		cervix(1)|endometrium(2)|lung(6)	9						CCTGCTTGCTCGCAGGCATCC	0.542000													4	174					0	0	1	0	0
LRRC4B	94030	broad.mit.edu	37	19	51022129	51022129	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:51022129C>T	ENST00000599957.1	-	3	1038	c.841G>A	c.(841-843)Gag>Aag	p.E281K	LRRC4B_ENST00000389201.3_Missense_Mutation_p.E281K			Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B	281						cell junction|integral to membrane|presynaptic membrane				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(1)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	30		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		AGGTTGAGCTCCTCCAGCGAC	0.642000													34	90					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	118105430	118105430	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:118105430C>T	ENST00000425217.1	-	5	987	c.933G>A	c.(931-933)aaG>aaA	p.K311K	KSR2_ENST00000545002.1_5'UTR|KSR2_ENST00000339824.5_Silent_p.K340K|KSR2_ENST00000302438.5_Silent_p.K37K	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	340					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TGCTGTGGATCTTGAGGTTCA	0.542000													9	30					0	0	1	0	0
CEACAM20	125931	broad.mit.edu	37	19	45026919	45026919	+	RNA	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:45026919G>A	ENST00000454753.1	-	0	773							Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 20							integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)	15		Prostate(69;0.0352)				ACTCCAATTTGATTTCAACAG	0.493000													3	5					0	0	1	0	0
TRIML2	205860	broad.mit.edu	37	4	189026074	189026074	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr4:189026074C>T	ENST00000512729.1	-	2	426	c.52G>A	c.(52-54)Gaa>Aaa	p.E18K	TRIML2_ENST00000326754.3_Missense_Mutation_p.E18K|TRIML2_ENST00000536972.1_Missense_Mutation_p.E68K	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	18							ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		TTCAATATTTCCTGGAATAAC	0.393000													23	56					0	0	1	0	0
ALOXE3	59344	broad.mit.edu	37	17	8006773	8006773	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:8006773G>A	ENST00000380149.1	-	14	2322	c.2292C>T	c.(2290-2292)tcC>tcT	p.S764S	ALOXE3_ENST00000318227.3_Silent_p.S740S|ALOXE3_ENST00000448843.2_Silent_p.S608S			Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3	608					leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)	31						GCTGCCTCATGGATGATGGAG	0.577000													25	31					0	0	1	0	0
CCDC178	374864	broad.mit.edu	37	18	30873195	30873195	+	Silent	SNP	C	C	T	rs138698300		TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr18:30873195C>T	ENST00000383096.3	-	12	1286	c.1104G>A	c.(1102-1104)aaG>aaA	p.K368K	CCDC178_ENST00000583930.1_Silent_p.K368K|CCDC178_ENST00000402325.1_Silent_p.K368K|CCDC178_ENST00000403303.1_Silent_p.K368K|CCDC178_ENST00000579916.1_Intron|CCDC178_ENST00000300227.8_Silent_p.K368K|CCDC178_ENST00000406524.2_Silent_p.K368K|CCDC178_ENST00000579947.1_Silent_p.K368K					coiled-coil domain containing 178																		CTTCCTCTTCCTTCTCCTCAA	0.294000													8	15					0	0	1	0	0
PRR15L	79170	broad.mit.edu	37	17	46030548	46030548	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:46030548G>A	ENST00000300557.2	-	2	303	c.53C>T	c.(52-54)tCc>tTc	p.S18F	RP11-6N17.9_ENST00000582262.1_RNA	NM_024320.3	NP_077296.1	Q9BU68	PR15L_HUMAN	proline rich 15-like	18										NS(1)|cervix(1)|ovary(1)|pancreas(1)	4						TTTGGGAGTGGATTTCTTTTT	0.562000													62	118					0	0	1	0	0
PCDHA7	56141	broad.mit.edu	37	5	140213990	140213990	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:140213990G>A	ENST00000525929.1	+	1	22	c.22G>A	c.(22-24)Gac>Aac	p.D8N	PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA7_ENST00000378125.3_Missense_Mutation_p.D8N|PCDHA4_ENST00000512229.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000529310.1_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAATGGATACGACCCAGGGGG	0.458000													37	18					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110456989	110456989	+	Missense_Mutation	SNP	G	G	A	rs146630772	by1000genomes	TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr8:110456989G>A	ENST00000378402.5	+	38	4995	c.4891G>A	c.(4891-4893)Gaa>Aaa	p.E1631K		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1631	IPT/TIG 8.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TGGTATCAGGGAAACTGTCAC	0.413000										HNSCC(38;0.096)			91	154					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142612202	142612202	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:142612202G>A	ENST00000265310.1	-	11	1649	c.1301C>T	c.(1300-1302)tCc>tTc	p.S434F		NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	434					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					CAGCACCAGGGAGGCATAGGT	0.567000													9	29					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16262471	16262471	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:16262471A>C	ENST00000375759.3	+	11	9940	c.9736A>C	c.(9736-9738)Acc>Ccc	p.T3246P		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	3246	Pro-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		ccccacccccacccctgcccc	0.662000													3	9					0	0	1	0	0
ZZEF1	23140	broad.mit.edu	37	17	3984774	3984774	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:3984774G>T	ENST00000381638.2	-	18	2849	c.2725C>A	c.(2725-2727)Cca>Aca	p.P909T	ZZEF1_ENST00000574474.1_5'UTR	NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	909							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						AGGCCGCCTGGATCCTTGTCA	0.453000													33	46					4.3181e-19	4.40417e-19	1	1	0
GH1	2688	broad.mit.edu	37	17	61995792	61995792	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:61995792T>C	ENST00000323322.5	-	2	127	c.85A>G	c.(85-87)Acc>Gcc	p.T29A	CSHL1_ENST00000392824.4_Intron|GH1_ENST00000351388.4_Missense_Mutation_p.T29A|GH1_ENST00000458650.2_Missense_Mutation_p.T29A|GH1_ENST00000342364.4_Missense_Mutation_p.T29A	NM_000515.3	NP_000506.2	P01241	SOMA_HUMAN	growth hormone 1	29					glucose transport|growth hormone receptor signaling pathway|JAK-STAT cascade|positive regulation of activation of JAK2 kinase activity|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of MAP kinase activity|positive regulation of multicellular organism growth|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|response to estradiol stimulus	extracellular space	growth factor activity|growth hormone receptor binding|hormone activity|metal ion binding|prolactin receptor binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)	19						AAGGGAATGGTTGGGAAGGCA	0.592000													96	145					0	0	1	0	0
IL17RC	84818	broad.mit.edu	37	3	9960211	9960211	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:9960211C>T	ENST00000295981.3	+	5	814	c.596C>T	c.(595-597)tCc>tTc	p.S199F	IL17RC_ENST00000498214.1_3'UTR|IL17RC_ENST00000403601.3_Missense_Mutation_p.S128F|IL17RC_ENST00000413608.1_Missense_Mutation_p.S128F|IL17RC_ENST00000383812.4_Missense_Mutation_p.S128F|IL17RC_ENST00000416074.2_Intron|IL17RC_ENST00000455057.1_Missense_Mutation_p.S128F	NM_153461.3	NP_703191.1	Q8NAC3	I17RC_HUMAN	interleukin 17 receptor C	199						integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(3)|ovary(3)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						GTCGTGCTCTCCTTCCAGGCC	0.617000													36	21					0	0	1	0	0
IGSF9B	22997	broad.mit.edu	37	11	133807295	133807295	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:133807295G>A	ENST00000321016.8	-	5	885	c.655C>T	c.(655-657)Cac>Tac	p.H219Y	IGSF9B_ENST00000533871.2_Missense_Mutation_p.H219Y			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	219	Ig-like 2.					integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		TGAGTCGTGTGGACAGCCTCC	0.632000													6	27					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16893773	16893773	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:16893773G>A	ENST00000430580.2	-	25	3627	c.2740C>T	c.(2740-2742)Cct>Tct	p.P914S	NBPF1_ENST00000420031.2_3'UTR|NBPF1_ENST00000432949.1_3'UTR	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	914	NBPF 5.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TAACCTGAAGGAGTTGAATAA	0.483000													23	1022					0	0	1	0	0
CCDC129	223075	broad.mit.edu	37	7	31682628	31682628	+	Silent	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:31682628T>C	ENST00000319386.3	+	11	2193	c.1200T>C	c.(1198-1200)caT>caC	p.H400H	CCDC129_ENST00000451887.2_Silent_p.H574H|CCDC129_ENST00000407970.3_Silent_p.H548H|CCDC129_ENST00000409210.1_Silent_p.H456H			Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	548										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						CAATGCCCCATGCTGAGTATG	0.522000													72	119					0	0	1	0	0
PCDHGA11	56105	broad.mit.edu	37	5	140801768	140801768	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:140801768G>A	ENST00000398587.2	+	1	1007	c.974G>A	c.(973-975)gGt>gAt	p.G325D	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA11_ENST00000518882.1_Missense_Mutation_p.G325D|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA8_ENST00000398604.2_Intron	NM_018914.2|NM_032092.1	NP_061737.1|NP_114481.1														breast(3)|endometrium(8)|kidney(3)|large_intestine(9)|lung(22)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCCAAGATGGTGGAGGTCTC	0.388000													29	24					0	0	1	0	0
NPHS1	4868	broad.mit.edu	37	19	36340038	36340038	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:36340038C>T	ENST00000378910.5	-	8	851	c.852G>A	c.(850-852)ccG>ccA	p.P284P	NPHS1_ENST00000353632.6_Silent_p.P284P	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	284	Ig-like C2-type 3.				cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTGTGGACACCGGCTGGCCAT	0.677000													19	51					0	0	1	0	0
TRBV10-2	28584	broad.mit.edu	37	7	142206692	142206692	+	RNA	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:142206692G>A	ENST00000426318.2	-	0	213																											AGGTCTTGTCGATACCAGAAC	0.493000													63	99					0	0	1	0	0
SLC6A5	9152	broad.mit.edu	37	11	20649599	20649599	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:20649599C>T	ENST00000525748.1	+	9	1742	c.1469C>T	c.(1468-1470)tCt>tTt	p.S490F		NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	490					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	ACTCTCTCTTCTTACAACAAA	0.453000													16	54					0	0	1	0	0
ABCB5	340273	broad.mit.edu	37	7	20721258	20721258	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:20721258G>A	ENST00000404938.2	+	15	2490	c.1838G>A	c.(1837-1839)cGa>cAa	p.R613Q	ABCB5_ENST00000258738.6_Missense_Mutation_p.R168Q	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	168	ABC transporter 2.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						ATGGCAAAACGAGGTCTATAT	0.418000													23	48					0	0	1	0	0
TNS1	7145	broad.mit.edu	37	2	218712359	218712359	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr2:218712359G>C	ENST00000171887.4	-	17	2958	c.2506C>G	c.(2506-2508)Cca>Gca	p.P836A	TNS1_ENST00000419504.1_Missense_Mutation_p.P836A|TNS1_ENST00000430930.1_Missense_Mutation_p.P836A	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	836						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		AGAGAGGCTGGGGGTTGCTGA	0.602000													80	12					0	0	1	0	0
OR5H6	79295	broad.mit.edu	37	3	97983531	97983531	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:97983531G>A	ENST00000383696.2	+	1	444	c.403G>A	c.(403-405)Gca>Aca	p.A135T	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005479.1	NP_001005479.1	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)	135					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						GGCAACAATGGCATATGATCG	0.368000													20	60					0	0	1	0	0
CCL7	6354	broad.mit.edu	37	17	32598218	32598218	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:32598218C>T	ENST00000378569.2	+	2	200	c.130C>T	c.(130-132)Cct>Tct	p.P44S	CCL7_ENST00000394630.3_Intron|CCL7_ENST00000394627.1_Silent_p.S61S|CCL7_ENST00000200307.4_Missense_Mutation_p.P54S	NM_006273.2	NP_006264.2	P80098	CCL7_HUMAN	chemokine (C-C motif) ligand 7	44					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|immune response|inflammatory response|signal transduction	extracellular space	chemokine activity|heparin binding			autonomic_ganglia(1)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)	7	Breast(3;0.00224)	Breast(31;0.151)|Ovarian(249;0.17)		BRCA - Breast invasive adenocarcinoma(366;0.155)		TAAGAAAATCCCTAAGCAGAG	0.478000													21	62					0	0	1	0	0
SCAF1	58506	broad.mit.edu	37	19	50156274	50156274	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:50156274C>T	ENST00000360565.3	+	7	2752	c.2628C>T	c.(2626-2628)ttC>ttT	p.F876F		NM_021228.2	NP_067051.2	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	876					mRNA processing|RNA splicing	nucleus	RNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	20		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		GCTCCCCCTTCCTCAAACCTG	0.647000													15	28					0	0	1	0	0
CAGE1	285782	broad.mit.edu	37	6	7355291	7355291	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr6:7355291G>A	ENST00000502583.1	-	11	2916	c.2352C>T	c.(2350-2352)tcC>tcT	p.S784S	CAGE1_ENST00000338150.4_Silent_p.S749S|CAGE1_ENST00000296742.7_Silent_p.S586S|CAGE1_ENST00000512086.1_Silent_p.S722S|CAGE1_ENST00000379918.4_Silent_p.S762S	NM_001170692.1	NP_001164163.1	Q8TC20	CAGE1_HUMAN	cancer antigen 1	722										breast(1)|cervix(1)|endometrium(3)|kidney(2)|lung(11)|urinary_tract(1)	19	Ovarian(93;0.0418)					TCTGGGAGTGGGATATTGCAA	0.294000													24	45					0	0	1	0	0
CCDC37	348807	broad.mit.edu	37	3	126135159	126135159	+	Splice_Site	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:126135159G>A	ENST00000393425.1	+	5	325	c.225_splice	c.e5-1	p.E76_splice	CCDC37_ENST00000505024.1_Splice_Site_p.E76_splice|CCDC37_ENST00000352312.1_Splice_Site_p.E76_splice			Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	76										NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|skin(3)	23				GBM - Glioblastoma multiforme(114;0.166)		ACGCCCCCAGGAACGGCAGCA	0.697000													23	25					0	0	1	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202563	140202563	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:140202563G>A	ENST00000529859.1	+	1	1203	c.1203G>A	c.(1201-1203)aaG>aaA	p.K401K	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000378126.3_Silent_p.K401K|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Silent_p.K401K|PCDHA4_ENST00000512229.2_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCACCTTCAAGAATTACTACT	0.617000													65	60					0	0	1	0	0
NUTM2B-AS1	101060691	broad.mit.edu	37	10	81442945	81442945	+	RNA	SNP	G	G	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr10:81442945G>C	ENST00000600376.1	-	0	54				RP11-119F19.2_ENST00000596088.1_RNA																							CAGGCATGTGGAACCCGAGAA	0.647000													8	10					0	0	1	0	0
UVRAG	7405	broad.mit.edu	37	11	75852428	75852428	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:75852428C>T	ENST00000356136.3	+	15	2312	c.2071C>T	c.(2071-2073)Cgc>Tgc	p.R691C	UVRAG_ENST00000538870.1_Missense_Mutation_p.R247C|UVRAG_ENST00000539288.1_Missense_Mutation_p.R319C|UVRAG_ENST00000528420.1_Missense_Mutation_p.R590C|UVRAG_ENST00000532130.1_Missense_Mutation_p.R319C|UVRAG_ENST00000531818.1_Missense_Mutation_p.R319C|UVRAG_ENST00000533454.1_Missense_Mutation_p.R319C	NM_003369.3	NP_003360.2	Q9P2Y5	UVRAG_HUMAN	UV radiation resistance associated	691					DNA repair|positive regulation of autophagy	early endosome|late endosome|lysosome	protein binding			central_nervous_system(1)|cervix(3)|endometrium(3)|kidney(1)|large_intestine(2)|lung(15)|skin(5)|urinary_tract(2)	32						ATCCAGCTTCCGCCGGCCGCG	0.507000													26	53					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	166996050	166996050	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr4:166996050G>A	ENST00000061240.2	+	17	2856	c.2209G>A	c.(2209-2211)Gat>Aat	p.D737N	TLL1_ENST00000507499.1_Missense_Mutation_p.D760N	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	737	EGF-like 2; calcium-binding (Potential).				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		ATGCTCTAAGGATAATGGTGG	0.388000													34	53					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89388803	89388803	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr15:89388803G>A	ENST00000439576.2	+	7	1493	c.1119G>A	c.(1117-1119)caG>caA	p.Q373Q	ACAN_ENST00000561243.1_Silent_p.Q373Q|ACAN_ENST00000559004.1_Silent_p.Q373Q|ACAN_ENST00000558207.1_Silent_p.Q373Q|ACAN_ENST00000352105.7_Silent_p.Q373Q	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	373					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TCACCGTCCAGACAGTGACCT	0.557000													26	47					0	0	1	0	0
CYP2C9	1559	broad.mit.edu	37	10	96741038	96741038	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr10:96741038G>A	ENST00000260682.6	+	7	1072	c.1060G>A	c.(1060-1062)Gag>Aag	p.E354K		NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	354					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	TGTGGTGCACGAGGTCCAGAG	0.502000													62	86					0	0	1	0	0
KIAA0319	9856	broad.mit.edu	37	6	24559339	24559339	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr6:24559339A>C	ENST00000535378.1	-	18	3251	c.2609T>G	c.(2608-2610)gTt>gGt	p.V870G	KIAA0319_ENST00000543707.1_Missense_Mutation_p.V879G|KIAA0319_ENST00000537886.1_Missense_Mutation_p.V879G|KIAA0319_ENST00000378214.3_Missense_Mutation_p.V879G|KIAA0319_ENST00000430948.2_Missense_Mutation_p.V834G	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	879					negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						AGCTTTGAGAACCTTGAAAGG	0.502000													6	31					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79032663	79032663	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:79032663A>G	ENST00000446378.2	+	2	8106	c.8075A>G	c.(8074-8076)gAa>gGa	p.E2692G		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2692						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		ATCACAAAAGAAACTGTGAAA	0.398000													3	22					0	0	1	0	0
ZNF524	147807	broad.mit.edu	37	19	56114158	56114158	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:56114158T>C	ENST00000591046.1	+	1	914	c.680T>C	c.(679-681)gTa>gCa	p.V227A	ZNF524_ENST00000301073.3_Missense_Mutation_p.V227A			Q96C55	ZN524_HUMAN	zinc finger protein 524	227					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|large_intestine(2)|lung(6)|prostate(1)	10			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		GCCATGGGGGTACCCCTGTGT	0.687000													8	23					0	0	1	0	0
KIF5A	3798	broad.mit.edu	37	12	57963426	57963426	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:57963426G>A	ENST00000455537.2	+	11	1351	c.1077G>A	c.(1075-1077)acG>acA	p.T359T	KIF5A_ENST00000286452.5_Silent_p.T270T	NM_004984.2	NP_004975.2	Q12840	KIF5A_HUMAN	kinesin family member 5A	359					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(32)|ovary(2)|prostate(2)|skin(2)	62						agaaggagaCGATTGCGAAGC	0.527000													17	45					0	0	1	0	0
MANEA	79694	broad.mit.edu	37	6	96034467	96034467	+	Missense_Mutation	SNP	G	G	A	rs148222739		TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr6:96034467G>A	ENST00000358812.4	+	2	286	c.152G>A	c.(151-153)cGa>cAa	p.R51Q	MANEA_ENST00000369293.1_Missense_Mutation_p.R51Q	NM_024641.3	NP_078917.2	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	51					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			breast(2)|endometrium(3)|kidney(2)|liver(2)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		CTTCATCAACGAACTATTCAT	0.333000													35	15					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9069397	9069397	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:9069397C>T	ENST00000397910.4	-	3	18252	c.18049G>A	c.(18049-18051)Ggg>Agg	p.G6017R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6019	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTGGTGGTCCCCATATTGGTT	0.453000													76	155					0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197026490	197026490	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:197026490A>G	ENST00000367412.1	-	6	954	c.911T>C	c.(910-912)cTt>cCt	p.L304P		NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	304	Sushi 5.				blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						CTCAAAATTAAGTTCACATTC	0.383000													34	51					0	0	1	0	0
SORBS1	10580	broad.mit.edu	37	10	97097017	97097017	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr10:97097017G>A	ENST00000371247.2	-	30	3089	c.2900C>T	c.(2899-2901)cCc>cTc	p.P967L	SORBS1_ENST00000371246.2_Intron|SORBS1_ENST00000306402.6_Intron|SORBS1_ENST00000347291.4_Intron|SORBS1_ENST00000353505.5_Intron|SORBS1_ENST00000361941.3_Missense_Mutation_p.P967L|SORBS1_ENST00000371245.3_Intron|SORBS1_ENST00000393949.1_Intron|SORBS1_ENST00000371227.4_Missense_Mutation_p.P921L|SORBS1_ENST00000371241.1_Intron|SORBS1_ENST00000371239.1_Intron|SORBS1_ENST00000354106.3_Intron|SORBS1_ENST00000607232.1_Intron|SORBS1_ENST00000371249.2_Intron|SORBS1_ENST00000277982.5_Intron			Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1	967					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(19)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		CAGAGATGAGGGGGCTGGCGT	0.532000													7	15					0	0	1	0	0
TTPA	7274	broad.mit.edu	37	8	63976827	63976827	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr8:63976827C>T	ENST00000260116.4	-	4	632	c.601G>A	c.(601-603)Gta>Ata	p.V201I	TTPA_ENST00000521138.1_Intron	NM_000370.3	NP_000361.1	P49638	TTPA_HUMAN	tocopherol (alpha) transfer protein	201	CRAL-TRIO.				lipid metabolic process		transporter activity|vitamin E binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)	15	Breast(64;0.0716)	all_cancers(86;0.145)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.123)			Vitamin E(DB00163)	TGGAAAATTACTGGTTCATTT	0.308000													12	17					0	0	1	0	0
CYP4B1	1580	broad.mit.edu	37	1	47282778	47282778	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:47282778T>C	ENST00000271153.4	+	9	1165	c.1129T>C	c.(1129-1131)Tac>Cac	p.Y377H	CYP4B1_ENST00000371923.4_Missense_Mutation_p.Y378H|CYP4B1_ENST00000452782.2_Missense_Mutation_p.Y215H|CYP4B1_ENST00000371919.4_Missense_Mutation_p.Y363H			P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B, polypeptide 1	377					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	36	Acute lymphoblastic leukemia(166;0.155)					CTTCCGCCTCTACCCACCTGT	0.557000													47	68					0	0	1	0	0
PTPRA	5786	broad.mit.edu	37	20	3016448	3016448	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr20:3016448C>T	ENST00000216877.6	+	21	2432	c.2032C>T	c.(2032-2034)Cgg>Tgg	p.R678W	PTPRA_ENST00000399903.2_Missense_Mutation_p.R687W|PTPRA_ENST00000358719.4_Missense_Mutation_p.R543W|PTPRA_ENST00000380393.3_Missense_Mutation_p.R687W|PTPRA_ENST00000425918.2_Missense_Mutation_p.R698W|PTPRA_ENST00000318266.5_Missense_Mutation_p.R678W|PTPRA_ENST00000356147.3_Missense_Mutation_p.R678W	NM_080840.2	NP_543030.1	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	687	Tyrosine-protein phosphatase 2.				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						GAATAAGAGCCGGCAGATCCG	0.577000													20	40					0	0	1	0	0
CFHR2	3080	broad.mit.edu	37	1	196918671	196918671	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:196918671G>A	ENST00000367415.4	+	2	259	c.145G>A	c.(145-147)Gaa>Aaa	p.E49K	CFHR2_ENST00000367421.3_Missense_Mutation_p.E49K|CFHR2_ENST00000476712.1_3'UTR	NM_005666.2	NP_005657.1	P36980	FHR2_HUMAN	complement factor H-related 2	49	Sushi 1.					extracellular region				large_intestine(2)|ovary(1)|skin(3)	6						TCCTACAGGGGAAGTTTTCTA	0.363000													18	29					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25490679	25490679	+	RNA	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr15:25490679C>T	ENST00000453082.2	+	0	2719				SNORD115-41_ENST00000363608.1_RNA	NR_003343.1																						ACTTAAAAATCATGCTCAATA	0.498000													179	232					0	0	1	0	0
ZMYM3	9203	broad.mit.edu	37	X	70470392	70470392	+	Silent	SNP	C	C	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chrX:70470392C>A	ENST00000373998.1	-	5	1660	c.963G>T	c.(961-963)ggG>ggT	p.G321G	ZMYM3_ENST00000373978.1_Intron|ZMYM3_ENST00000373988.1_Silent_p.G323G|ZMYM3_ENST00000489332.1_5'UTR|ZMYM3_ENST00000373981.1_Silent_p.G321G|ZMYM3_ENST00000373982.1_Silent_p.G323G|ZMYM3_ENST00000353904.2_Silent_p.G321G|ZMYM3_ENST00000373984.3_Silent_p.G323G|ZMYM3_ENST00000314425.5_Silent_p.G321G	NM_001171162.1	NP_001164633.1	Q14202	ZMYM3_HUMAN	zinc finger, MYM-type 3	321					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(7)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(17)|ovary(1)|prostate(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(35;0.156)					AGGCAGTCTGCCCCTTCTGCA	0.587000													10	3					1.58986e-06	1.60292e-06	1	1	0
PCLO	27445	broad.mit.edu	37	7	82784471	82784471	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:82784471A>G	ENST00000423517.2	-	2	1823	c.1486T>C	c.(1486-1488)Tca>Cca	p.S496P	PCLO_ENST00000333891.8_Missense_Mutation_p.S496P	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	442	10 X 10 AA tandem approximate repeats of P-A-K-P-Q-P-Q-Q-P-X.|Gln-rich.|Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity	p.S496P(6)|p.?(3)		breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GGCTTTGCTGAGCCAGGCTGT	0.607000													8	246					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62292039	62292039	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:62292039G>A	ENST00000378024.4	-	5	10124	c.9850C>T	c.(9850-9852)Cct>Tct	p.P3284S	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	3284					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TGCATGTCAGGCATCTTCAGT	0.428000													38	66					0	0	1	0	0
KCNU1	157855	broad.mit.edu	37	8	36644890	36644890	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr8:36644890C>T	ENST00000399881.3	+	2	299	c.262C>T	c.(262-264)Cgt>Tgt	p.R88C		NM_001031836.2	NP_001027006.2	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	88						voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(31)|ovary(1)|urinary_tract(1)	57				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		GGGACAATTTCGTGATCATAT	0.428000													6	11					0	0	1	0	0
OR14A16	284532	broad.mit.edu	37	1	247978451	247978451	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:247978451T>A	ENST00000357627.1	-	1	580	c.581A>T	c.(580-582)gAa>gTa	p.E194V		NM_001001966.1	NP_001001966.1	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A, member 16	194					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(32)|skin(2)|stomach(1)	45						GAGTGCAATTTCTCTTATTAA	0.378000													23	38					0	0	1	0	0
KIR3DL1	3811	broad.mit.edu	37	19	55333135	55333135	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:55333135G>A	ENST00000391728.4	+	5	804	c.771G>A	c.(769-771)agG>agA	p.R257R	KIR3DL1_ENST00000538269.1_Silent_p.R257R|KIR3DL1_ENST00000541392.1_Silent_p.R257R|KIR3DL1_ENST00000402254.2_Silent_p.R257R|KIR3DL1_ENST00000326542.7_Silent_p.R257R|KIR3DL1_ENST00000358178.4_Silent_p.R162R	NM_013289.2	NP_037421.2			killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1											breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(193;0.0192)		ATCTATCCAGGGAGGGGGGAG	0.612000													17	31					0	0	1	0	0
KIR3DL1	3811	broad.mit.edu	37	19	55333136	55333136	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:55333136G>A	ENST00000391728.4	+	5	805	c.772G>A	c.(772-774)Gag>Aag	p.E258K	KIR3DL1_ENST00000538269.1_Missense_Mutation_p.E258K|KIR3DL1_ENST00000541392.1_Missense_Mutation_p.E258K|KIR3DL1_ENST00000402254.2_Missense_Mutation_p.E258K|KIR3DL1_ENST00000326542.7_Missense_Mutation_p.E258K|KIR3DL1_ENST00000358178.4_Missense_Mutation_p.E163K	NM_013289.2	NP_037421.2			killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1											breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(193;0.0192)		TCTATCCAGGGAGGGGGGAGC	0.607000													17	30					0	0	1	0	0
CTNNA3	29119	broad.mit.edu	37	10	68139018	68139018	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr10:68139018C>T	ENST00000433211.1	-	12	1798	c.1624G>A	c.(1624-1626)Ggc>Agc	p.G542S	CTNNA3_ENST00000373744.4_Missense_Mutation_p.G542S	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	542					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						GCTGCCCGGCCTCTGATAGCA	0.473000													35	53					0	0	1	0	0
HPGDS	27306	broad.mit.edu	37	4	95239111	95239111	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr4:95239111G>A	ENST00000295256.5	-	3	229	c.139C>T	c.(139-141)Cca>Tca	p.P47S	HPGDS_ENST00000514774.1_5'UTR	NM_014485.2	NP_055300.1	O60760	HPGDS_HUMAN	hematopoietic prostaglandin D synthase	47	GST N-terminal.				locomotory behavior|prostaglandin biosynthetic process|signal transduction	cytoplasm|nucleus	calcium ion binding|glutathione transferase activity|magnesium ion binding|prostaglandin-D synthase activity|protein homodimerization activity			breast(1)|cervix(1)|lung(3)|ovary(1)|urinary_tract(1)	7					Glutathione(DB00143)	TTTCCAAATGGGAGAGCTTAA	0.328000													13	26					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71103196	71103196	+	Missense_Mutation	SNP	G	G	A	rs140028548		TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:71103196G>A	ENST00000393567.2	-	14	2098	c.1948C>T	c.(1948-1950)Cgc>Tgc	p.R650C	HYDIN_ENST00000321489.5_Missense_Mutation_p.R650C|HYDIN_ENST00000288168.10_Missense_Mutation_p.R667C|HYDIN_ENST00000393550.2_Missense_Mutation_p.R665C|HYDIN_ENST00000541601.1_Missense_Mutation_p.R667C|HYDIN_ENST00000448089.2_Missense_Mutation_p.R650C|HYDIN_ENST00000448691.1_Missense_Mutation_p.R650C|HYDIN_ENST00000538248.1_Missense_Mutation_p.R677C	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	650										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				CCCTGGGGGCGAATGGTGCCA	0.488000													33	47					0	0	1	0	0
C15orf39	56905	broad.mit.edu	37	15	75500581	75500581	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr15:75500581G>A	ENST00000360639.2	+	2	2512	c.2192G>A	c.(2191-2193)cGa>cAa	p.R731Q	C15orf39_ENST00000394987.4_Missense_Mutation_p.R731Q|C15orf39_ENST00000567617.1_Missense_Mutation_p.R731Q			Q6ZRI6	CO039_HUMAN	chromosome 15 open reading frame 39	731										autonomic_ganglia(1)|breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	16						gctccggctcgagctcaggct	0.672000													11	9					0	0	1	0	0
EPB41L4B	54566	broad.mit.edu	37	9	111970230	111970230	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr9:111970230C>T	ENST00000374566.3	-	18	2369	c.1852G>A	c.(1852-1854)Gaa>Aaa	p.E618K		NM_019114.3	NP_061987.3	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	618						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GAAGCATTTTCCAACTGGGCT	0.453000													41	25					0	0	1	0	0
IGSF21	84966	broad.mit.edu	37	1	18702856	18702856	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:18702856G>A	ENST00000251296.1	+	7	1451	c.1068G>A	c.(1066-1068)ggG>ggA	p.G356G	IGSF21_ENST00000473951.1_3'UTR	NM_032880.4	NP_116269.3	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21	356	Ig-like 2.					extracellular region				endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	40		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		CCCGGGTAGGGGACACAGTGA	0.587000													60	124					0	0	1	0	0
PARG	8505	broad.mit.edu	37	10	51093329	51093329	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr10:51093329C>T	ENST00000402038.3	-	4	294	c.295G>A	c.(295-297)Gca>Aca	p.A99T		NM_003631.2	NP_003622.2	Q86W56	PARG_HUMAN	poly (ADP-ribose) glycohydrolase	584					carbohydrate metabolic process	nucleus	poly(ADP-ribose) glycohydrolase activity	p.A584T(1)		endometrium(5)|kidney(2)|lung(1)|ovary(2)	10				Epithelial(53;0.213)		TGAGCTTCTGCTTCTTCAAGT	0.318000													6	67					0	0	1	0	0
ARHGEF15	22899	broad.mit.edu	37	17	8222094	8222094	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:8222094G>A	ENST00000361926.3	+	12	2009	c.1899G>A	c.(1897-1899)cgG>cgA	p.R633R	ARHGEF15_ENST00000421050.1_Silent_p.R633R|ARHGEF15_ENST00000582060.1_3'UTR	NM_173728.3	NP_776089.2	O94989	ARHGF_HUMAN	Rho guanine nucleotide exchange factor (GEF) 15	633					negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(9)|large_intestine(5)|lung(11)|ovary(5)|prostate(3)|skin(2)|urinary_tract(1)	37						CCTGGTCACGGCGCCTGGAAT	0.667000													81	166					0	0	1	0	0
LRRC30	339291	broad.mit.edu	37	18	7231246	7231246	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr18:7231246G>A	ENST00000383467.2	+	1	124	c.110G>A	c.(109-111)gGa>gAa	p.G37E		NM_001105581.1	NP_001099051.1	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	37										central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						CTGCTCTCGGGAAGGGACCCG	0.612000													23	52					0	0	1	0	0
ZNF585B	92285	broad.mit.edu	37	19	37677079	37677079	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:37677079G>A	ENST00000532828.2	-	5	1611	c.1360C>T	c.(1360-1362)Cat>Tat	p.H454Y	ZNF585B_ENST00000531805.1_Missense_Mutation_p.H399Y|ZNF585B_ENST00000527838.1_3'UTR|CTC-454I21.3_ENST00000585860.2_Intron|ZNF585B_ENST00000312908.5_Missense_Mutation_p.H42Y	NM_152279.3	NP_689492.3	Q52M93	Z585B_HUMAN	zinc finger protein 585B	454					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)	29			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTATGAACATGGAGTTGTGAC	0.393000													46	62					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124267782	124267782	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:124267782G>A	ENST00000409039.3	+	7	812	c.787G>A	c.(787-789)Gtt>Att	p.V263I		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	263	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ATCCACAGCGGTTGAGGCCCA	0.547000													21	42					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147600754	147600754	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:147600754C>T	ENST00000361727.3	+	14	2712	c.2196C>T	c.(2194-2196)atC>atT	p.I732I		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	732	Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding	p.I732I(2)		NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CCTGCGGCATCGAACGCAACT	0.572000										HNSCC(39;0.1)			14	13					0	0	1	0	0
ZNF513	130557	broad.mit.edu	37	2	27600690	27600690	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr2:27600690T>C	ENST00000323703.6	-	4	1546	c.1348A>G	c.(1348-1350)Aac>Gac	p.N450D	ZNF513_ENST00000407879.1_Missense_Mutation_p.N388D|ZNF513_ENST00000491924.1_5'UTR	NM_144631.5	NP_653232.3	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	450					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)	17	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGCTGTAGTTGCAAAGGCTA	0.577000													222	54					0	0	1	0	0
STYXL1	51657	broad.mit.edu	37	7	75625831	75625831	+	Silent	SNP	A	A	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:75625831A>G	ENST00000248600.1	-	9	1239	c.897T>C	c.(895-897)acT>acC	p.T299T	STYXL1_ENST00000360591.3_3'UTR|STYXL1_ENST00000340062.5_Silent_p.T203T|STYXL1_ENST00000431581.1_Silent_p.T299T|STYXL1_ENST00000359697.3_Silent_p.T299T	NM_016086.2	NP_057170.1	Q9Y6J8	STYL1_HUMAN	serine/threonine/tyrosine interacting-like 1	299	Tyrosine-protein phosphatase.				intracellular signal transduction|protein dephosphorylation	intracellular	protein binding|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	10						CTCCAAGGATAGTCTTCTCCC	0.498000													20	30					0	0	1	0	0
PIGO	84720	broad.mit.edu	37	9	35092254	35092254	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr9:35092254G>A	ENST00000378617.3	-	7	2024	c.1630C>T	c.(1630-1632)Ccc>Tcc	p.P544S	PIGO_ENST00000298004.5_Intron|PIGO_ENST00000341666.3_Missense_Mutation_p.P544S|PIGO_ENST00000361778.2_Intron	NM_032634.3	NP_116023.2	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class O	544					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			endometrium(3)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)	38			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			CCAGGGATGGGAAACAGGGTT	0.577000													28	14					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82595633	82595633	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:82595633C>T	ENST00000423517.2	-	4	3808	c.3471G>A	c.(3469-3471)gtG>gtA	p.V1157V	PCLO_ENST00000333891.8_Silent_p.V1157V	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1096					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CTTGCTTTTTCACTAATTTTA	0.398000													22	30					0	0	1	0	0
CPT1C	126129	broad.mit.edu	37	19	50214046	50214046	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:50214046G>A	ENST00000392518.4	+	16	2170	c.1798G>A	c.(1798-1800)Gag>Aag	p.E600K	CPT1C_ENST00000323446.5_Missense_Mutation_p.E600K|CPT1C_ENST00000405931.2_Missense_Mutation_p.E589K|CPT1C_ENST00000598293.1_Missense_Mutation_p.E600K|CPT1C_ENST00000354199.5_Missense_Mutation_p.E600K	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	600					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		AGGCCGGACGGAGACGGTGCG	0.587000													32	17					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31316359	31316359	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:31316359C>T	ENST00000265071.2	+	9	1700	c.1435C>T	c.(1435-1437)Cta>Tta	p.L479L	CDH6_ENST00000514738.1_Silent_p.L424L	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	479	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						TATTAAAGTTCTAGATGTCAA	0.353000													15	22					0	0	1	0	0
APP	351	broad.mit.edu	37	21	27254055	27254055	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr21:27254055G>A	ENST00000358918.3	-	17	2384	c.2185C>T	c.(2185-2187)Cgc>Tgc	p.R729C	APP_ENST00000359726.3_Missense_Mutation_p.R691C|APP_ENST00000354192.3_Missense_Mutation_p.R616C|APP_ENST00000348990.5_Missense_Mutation_p.R672C|APP_ENST00000448388.2_Missense_Mutation_p.R637C|APP_ENST00000346798.3_Missense_Mutation_p.R747C|APP_ENST00000440126.3_Missense_Mutation_p.R723C|APP_ENST00000439274.2_Missense_Mutation_p.R691C|APP_ENST00000357903.3_Missense_Mutation_p.R728C	NM_001204301.1|NM_001204302.1	NP_001191230.1|NP_001191231.1	P05067	A4_HUMAN	amyloid beta (A4) precursor protein	747					adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			endometrium(5)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	22		Breast(209;0.00295)				GACAGGTGGCGCTCCTCTGGG	0.478000											OREG0026148	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	59					0	0	1	0	0
RAG2	5897	broad.mit.edu	37	11	36614779	36614779	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:36614779T>A	ENST00000311485.3	-	2	1101	c.940A>T	c.(940-942)Agc>Tgc	p.S314C		NM_000536.3|NM_001243785.1|NM_001243786.1	NP_000527.2|NP_001230714.1|NP_001230715.1	P55895	RAG2_HUMAN	recombination activating gene 2	314					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|pancreas(2)|prostate(1)|skin(4)	32	all_lung(20;0.226)	all_hematologic(20;0.00756)				CATATCTTGCTGTGCTTAATG	0.378000									Familial Hemophagocytic Lymphohistiocytosis				68	106					0	0	1	0	0
LRRC15	131578	broad.mit.edu	37	3	194080037	194080037	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:194080037T>A	ENST00000347624.3	-	2	1821	c.1736A>T	c.(1735-1737)aAt>aTt	p.N579I	LRRC15_ENST00000439944.2_Missense_Mutation_p.N585I|LRRC15_ENST00000428839.1_Missense_Mutation_p.N585I	NM_130830.4	NP_570843.2	Q8TF66	LRC15_HUMAN	leucine rich repeat containing 15	579						integral to membrane				biliary_tract(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(20)|ovary(4)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.94e-05)		TTAACACTCATTGGGTGCCTT	0.587000													35	40					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58299218	58299218	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr13:58299218C>T	ENST00000377918.3	+	4	3296	c.3270C>T	c.(3268-3270)ttC>ttT	p.F1090F		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	1090					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		ACCCTCCCTTCATGGCTTCCG	0.532000													106	32					0	0	1	0	0
OR2B11	127623	broad.mit.edu	37	1	247614943	247614943	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:247614943C>T	ENST00000318749.6	-	1	365	c.342G>A	c.(340-342)acG>acA	p.T114T		NM_001004492.1	NP_001004492.1	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B, member 11	114					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(13)|large_intestine(7)|lung(31)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	60	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CGATGCACTCCGTGCATCCCA	0.597000													62	63					0	0	1	0	0
ANO9	338440	broad.mit.edu	37	11	428479	428479	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:428479G>A	ENST00000332826.6	-	13	1265	c.1181C>T	c.(1180-1182)aCc>aTc	p.T394I		NM_001012302.2	NP_001012302.2	A1A5B4	ANO9_HUMAN	anoctamin 9	394						chloride channel complex	chloride channel activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|lung(5)|ovary(1)|prostate(4)|skin(4)	21						CCCCACCTTGGTCATGATGAT	0.672000													23	61					0	0	1	0	0
GRAMD1B	57476	broad.mit.edu	37	11	123484182	123484182	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:123484182G>A	ENST00000529750.1	+	15	1941	c.1614G>A	c.(1612-1614)acG>acA	p.T538T	GRAMD1B_ENST00000456860.2_Silent_p.T545T|GRAMD1B_ENST00000322282.7_Silent_p.T538T|GRAMD1B_ENST00000450171.2_Silent_p.T229T	NM_020716.1	NP_065767.1	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	538						integral to membrane				NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		TGGCCAAAACGGAGAGCACTT	0.537000													11	11					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139160865	139160865	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr8:139160865A>C	ENST00000395297.1	-	14	3516	c.3346T>G	c.(3346-3348)Tta>Gta	p.L1116V		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1116										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			AGTACAGTTAAGTCACTGTAC	0.378000										HNSCC(54;0.14)			19	28					0	0	1	0	0
IGHV2-5	28457	broad.mit.edu	37	14	106494263	106494263	+	RNA	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr14:106494263C>T	ENST00000390597.2	-	0	248																											TAGCGCTTATCATCATTCCAA	0.542000													38	62					0	0	1	0	0
PCDHB17P	54661	broad.mit.edu	37	5	140537213	140537213	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:140537213C>T	ENST00000539533.1	+	1	1637	c.1637C>T	c.(1636-1638)gCg>gTg	p.A546V																								AGCAGCGAGGCGCTGGTGCGC	0.682000													53	34					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	211093366	211093366	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:211093366G>A	ENST00000367007.4	-	7	1166	c.997C>T	c.(997-999)Cgt>Tgt	p.R333C	KCNH1_ENST00000271751.4_Missense_Mutation_p.R360C	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	360					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CGCCCAAGACGGAGCAGCCGG	0.552000													44	64					0	0	1	0	0
SLC19A1	6573	broad.mit.edu	37	21	46957802	46957802	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr21:46957802G>A	ENST00000311124.4	-	2	224	c.72C>T	c.(70-72)tcC>tcT	p.S24S	SLC19A1_ENST00000380010.4_Silent_p.S24S|SLC19A1_ENST00000567670.1_Silent_p.S24S	NM_194255.2	NP_919231.1	P41440	S19A1_HUMAN	solute carrier family 19 (folate transporter), member 1	24					folic acid metabolic process	integral to plasma membrane|membrane fraction	folic acid binding|folic acid transporter activity|methotrexate transporter activity|reduced folate carrier activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	10				Colorectal(79;0.0569)|READ - Rectum adenocarcinoma(84;0.172)		GGTGCCGCCAGGACCGGAGCT	0.667000													5	11					0	0	1	0	0
GJC1	10052	broad.mit.edu	37	17	42882272	42882272	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:42882272G>A	ENST00000426548.1	-	3	1183	c.914C>T	c.(913-915)tCc>tTc	p.S305F	GJC1_ENST00000590758.1_Missense_Mutation_p.S305F|GJC1_ENST00000330514.4_Missense_Mutation_p.S305F|GJC1_ENST00000592524.1_Missense_Mutation_p.S305F	NM_001080383.1|NM_005497.3	NP_001073852.1|NP_005488.2	P36383	CXG1_HUMAN	gap junction protein, gamma 1, 45kDa	305					cellular membrane organization|gap junction assembly|muscle contraction|synaptic transmission|transport	connexon complex|integral to membrane				NS(1)|kidney(1)|large_intestine(5)|liver(1)|lung(10)|prostate(1)	19		Prostate(33;0.0959)				CTTAGCATTGGACAGTTCGGT	0.502000													62	108					0	0	1	0	0
DLG3	1741	broad.mit.edu	37	X	69674135	69674135	+	Silent	SNP	A	A	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chrX:69674135A>G	ENST00000194900.4	+	10	1769	c.1428A>G	c.(1426-1428)tcA>tcG	p.S476S	DLG3-AS1_ENST00000431103.1_RNA|DLG3_ENST00000374355.3_Silent_p.S121S|DLG3_ENST00000374360.3_Silent_p.S458S|DLG3-AS1_ENST00000424211.1_RNA			Q92796	DLG3_HUMAN	discs, large homolog 3 (Drosophila)	458					axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			endometrium(4)|kidney(1)|large_intestine(10)|lung(5)|pancreas(1)|urinary_tract(1)	22	Renal(35;0.156)					CCGGCCAGTCAGTCACCATTG	0.517000											OREG0019854	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	19					0	0	1	0	0
SMAD2	4087	broad.mit.edu	37	18	45374899	45374899	+	Nonsense_Mutation	SNP	A	A	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr18:45374899A>C	ENST00000402690.2	-	8	1338	c.944T>G	c.(943-945)tTa>tGa	p.L315*	SMAD2_ENST00000262160.6_Nonsense_Mutation_p.L315*|SMAD2_ENST00000591214.1_Nonsense_Mutation_p.L285*|SMAD2_ENST00000356825.4_Nonsense_Mutation_p.L285*|SMAD2_ENST00000586040.1_Nonsense_Mutation_p.L285*	NM_001003652.3	NP_001003652.1	Q15796	SMAD2_HUMAN	SMAD family member 2	315	MH2.				anterior/posterior pattern formation|cell fate commitment|common-partner SMAD protein phosphorylation|intracellular signal transduction|mesoderm formation|negative regulation of transcription, DNA-dependent|palate development|paraxial mesoderm morphogenesis|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|regulation of binding|regulation of transforming growth factor beta receptor signaling pathway|response to cholesterol|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	activin responsive factor complex|cytosol	activating transcription factor binding|co-SMAD binding|double-stranded DNA binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(21)|liver(1)|lung(8)|prostate(2)|urinary_tract(1)	43						ATTGGAGAGTAAACCTAAGCA	0.393000													40	56					0	0	1	0	0
KLHL24	54800	broad.mit.edu	37	3	183382784	183382784	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:183382784A>T	ENST00000454652.1	+	6	1567	c.1181A>T	c.(1180-1182)aAt>aTt	p.N394I	KLHL24_ENST00000242810.6_Missense_Mutation_p.N394I|KLHL24_ENST00000476808.1_Missense_Mutation_p.N394I			Q6TFL4	KLH24_HUMAN	kelch-like family member 24	394						axon|cytoplasm|perikaryon				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			GCCTCTCTCAATAAAGGCAGA	0.388000													40	62					0	0	1	0	0
ZNF391	346157	broad.mit.edu	37	6	27369105	27369105	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr6:27369105C>T	ENST00000244576.4	+	3	1501	c.956C>T	c.(955-957)tCc>tTc	p.S319F		NM_001076781.1	NP_001070249.1	Q9UJN7	ZN391_HUMAN	zinc finger protein 391	319					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|large_intestine(6)|lung(7)|pancreas(2)|skin(3)|upper_aerodigestive_tract(1)	21						CGAAGCTCATCCCTTATTATT	0.458000													26	49					0	0	1	0	0
ZMYM6	9204	broad.mit.edu	37	1	35452748	35452748	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:35452748G>A	ENST00000357182.4	-	16	4162	c.3935C>T	c.(3934-3936)tCt>tTt	p.S1312F	ZMYM6_ENST00000373340.2_Intron|ZMYM6_ENST00000487874.1_Intron|ZMYM6_ENST00000493328.1_5'UTR	NM_007167.3	NP_009098.3	O95789	ZMYM6_HUMAN	zinc finger, MYM-type 6	1312					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(10)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	44		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				TGGAATTAAAGATGTGACTGC	0.363000													15	27					0	0	1	0	0
UNC5B	219699	broad.mit.edu	37	10	73050720	73050720	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr10:73050720C>T	ENST00000335350.6	+	9	1564	c.1148C>T	c.(1147-1149)gCc>gTc	p.A383V	UNC5B_ENST00000373192.4_Missense_Mutation_p.A372V	NM_170744.4	NP_734465.2	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B (C. elegans)	383					apoptosis|axon guidance|regulation of apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(4)|skin(4)	49						CTCGTGGTGGCCATCTTCGTG	0.652000													96	165					0	0	1	0	0
ATP8A1	10396	broad.mit.edu	37	4	42627651	42627651	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr4:42627651G>A	ENST00000381668.5	-	3	475	c.244C>T	c.(244-246)Ctc>Ttc	p.L82F	ATP8A1_ENST00000264449.10_Missense_Mutation_p.L82F|ATP8A1_ENST00000510289.1_3'UTR	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	82					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	GCAATAAAGAGAAAAAATGAA	0.363000													18	36					0	0	1	0	0
SDHA	6389	broad.mit.edu	37	5	228396	228396	+	Missense_Mutation	SNP	G	G	C	rs1041946		TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:228396G>C	ENST00000264932.6	+	6	833	c.718G>C	c.(718-720)Gag>Cag	p.E240Q	SDHA_ENST00000510361.1_Missense_Mutation_p.E192Q|SDHA_ENST00000504309.1_Missense_Mutation_p.E240Q	NM_004168.2	NP_004159.2	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	240			E -> Q (in dbSNP:rs1041946).		nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity	p.E240Q(2)		NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|liver(2)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	40			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	ACTGTGCATAGAGGACGGGTC	0.418000									Familial Paragangliomas				3	68					0	0	1	0	0
THPO	7066	broad.mit.edu	37	3	184090874	184090874	+	Silent	SNP	C	C	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:184090874C>G	ENST00000204615.7	-	6	703	c.489G>C	c.(487-489)ctG>ctC	p.L163L	THPO_ENST00000421442.2_Intron|THPO_ENST00000477594.1_Intron|EIF2B5_ENST00000444495.1_Intron|THPO_ENST00000445696.2_Silent_p.L159L	NM_000460.2|NM_001177597.1|NM_001177598.1	NP_000451.1|NP_001171068.1|NP_001171069.1	P40225	TPO_HUMAN	thrombopoietin	163					cell proliferation|platelet activation	extracellular space	cytokine activity|growth factor activity|hormone activity			NS(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)	16	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CTACAAGCATCAGGAAACGCA	0.602000													30	53					0	0	1	0	0
PARD3	56288	broad.mit.edu	37	10	34400461	34400461	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr10:34400461G>A	ENST00000374789.3	-	25	4032	c.3707C>T	c.(3706-3708)tCc>tTc	p.S1236F	PARD3_ENST00000350537.4_Missense_Mutation_p.S1190F|PARD3_ENST00000346874.4_Missense_Mutation_p.S1199F|PARD3_ENST00000374788.3_Missense_Mutation_p.S1233F|PARD3_ENST00000545260.1_Missense_Mutation_p.S1146F|PARD3_ENST00000374794.3_Missense_Mutation_p.S1124F|PARD3_ENST00000374790.3_Missense_Mutation_p.S1176F|PARD3_ENST00000545693.1_Missense_Mutation_p.S1220F	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	1236					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				AGAGTCCTGGGAGACCGAGCT	0.557000													33	50					0	0	1	0	0
CATSPERB	79820	broad.mit.edu	37	14	92054374	92054374	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr14:92054374G>A	ENST00000256343.3	-	25	3161	c.3005C>T	c.(3004-3006)cCa>cTa	p.P1002L		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	1002					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				ACCAAGAATTGGTTCTACTAA	0.294000													8	10					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196651860	196651860	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr2:196651860G>A	ENST00000312428.6	-	58	10852	c.10752C>T	c.(10750-10752)ttC>ttT	p.F3584F	DNAH7_ENST00000409063.1_Silent_p.F67F	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3584	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AAGCATGAAAGAAACACAGGC	0.378000													52	17					0	0	1	0	0
STRIP2	57464	broad.mit.edu	37	7	129091562	129091562	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:129091562C>T	ENST00000249344.2	+	4	423	c.383C>T	c.(382-384)gCc>gTc	p.A128V	STRIP2_ENST00000435494.2_Missense_Mutation_p.A128V	NM_020704.2	NP_065755.1			striatin interacting protein 2																		CTGAAGGTGGCCCGGGCTGTT	0.557000													16	36					0	0	1	0	0
ILDR1	286676	broad.mit.edu	37	3	121712024	121712024	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:121712024C>T	ENST00000273691.3	-	6	1545	c.1440G>A	c.(1438-1440)agG>agA	p.R480R	ILDR1_ENST00000462014.1_Silent_p.R492R|ILDR1_ENST00000460554.1_5'UTR|ILDR1_ENST00000393631.1_Silent_p.R435R|ILDR1_ENST00000344209.5_Silent_p.R524R	NM_175924.3	NP_787120.1	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor 1	524						cytosol|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(114;0.156)		TCCCTTTTTTCCTGCTATTCT	0.647000													6	12					0	0	1	0	0
ZNF284	342909	broad.mit.edu	37	19	44591031	44591031	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:44591031C>T	ENST00000421176.3	+	5	1616	c.1400C>T	c.(1399-1401)gCc>gTc	p.A467V	ZNF223_ENST00000591793.1_3'UTR	NM_001037813.2	NP_001032902.1	Q2VY69	ZN284_HUMAN	zinc finger protein 284	467					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|kidney(2)|large_intestine(6)|lung(4)|upper_aerodigestive_tract(1)	15		Prostate(69;0.0435)				TTCAGGTGGGCCTCAGGTATT	0.418000													26	36					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103354475	103354475	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:103354475C>T	ENST00000358392.2	-	60	4818	c.4500_splice	c.e60-1	p.G1501_splice	COL11A1_ENST00000512756.1_Splice_Site_p.G1373_splice|COL11A1_ENST00000370096.3_Splice_Site_p.G1489_splice|COL11A1_ENST00000353414.4_Splice_Site_p.G1450_splice	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1489	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CCAGGAATTCCCTAGAGAGAG	0.368000													20	46					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89348950	89348950	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:89348950G>A	ENST00000301030.4	-	9	4460	c.4000C>T	c.(4000-4002)Ccg>Tcg	p.P1334S	ANKRD11_ENST00000378330.2_Missense_Mutation_p.P1334S	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1334	Lys-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CTCTCCCTCGGCTTGTCGTCT	0.612000													28	41					0	0	1	0	0
SIAH2	6478	broad.mit.edu	37	3	150459987	150459987	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:150459987G>A	ENST00000312960.3	-	2	1443	c.916C>T	c.(916-918)Ctt>Ttt	p.L306F		NM_005067.5	NP_005058.3	O43255	SIAH2_HUMAN	siah E3 ubiquitin protein ligase 2	306	SBD.				apoptosis|axon guidance|cell cycle|negative regulation of canonical Wnt receptor signaling pathway|small GTPase mediated signal transduction|ubiquitin-dependent protein catabolic process	cytosol|nucleus	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|pancreas(1)	16			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			TCTGCAAAAAGATGTGCTATG	0.463000													24	47					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49420453	49420453	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:49420453C>T	ENST00000301067.7	-	48	15295	c.15296G>A	c.(15295-15297)gGt>gAt	p.G5099D		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GCTGGTGGCACCAGTTCGCTG	0.572000													31	46					0	0	1	0	0
CCRN4L	25819	broad.mit.edu	37	4	139965951	139965951	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr4:139965951C>T	ENST00000280614.2	+	3	812	c.619C>T	c.(619-621)Ctc>Ttc	p.L207F	ELF2_ENST00000515489.1_Intron	NM_012118.2	NP_036250.2	Q9UK39	NOCT_HUMAN	CCR4 carbon catabolite repression 4-like (S. cerevisiae)	207					rhythmic process|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			kidney(2)|large_intestine(3)|lung(3)|ovary(1)	9	all_hematologic(180;0.162)					CCAGCCACTCCTCAGTAGACT	0.463000													26	53					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33144972	33144972	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr6:33144972G>A	ENST00000341947.2	-	24	2229	c.2002C>T	c.(2002-2004)Cct>Tct	p.P668S	COL11A2_ENST00000374713.1_Missense_Mutation_p.P621S|COL11A2_ENST00000395197.1_Missense_Mutation_p.P608S|COL11A2_ENST00000374714.1_Missense_Mutation_p.P642S|COL11A2_ENST00000374708.4_Missense_Mutation_p.P582S|COL11A2_ENST00000374712.1_Missense_Mutation_p.P587S|COL11A2_ENST00000361917.1_Missense_Mutation_p.P561S|COL11A2_ENST00000357486.1_Missense_Mutation_p.P647S|COL11A2_ENST00000477772.1_5'UTR	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	668	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						TCTCCATGAGGGCCGATGGCA	0.547000													23	41					0	0	1	0	0
FBLN5	10516	broad.mit.edu	37	14	92406930	92406930	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr14:92406930G>A	ENST00000267620.10	-	3	272	c.103C>T	c.(103-105)Cgc>Tgc	p.R35C	FBLN5_ENST00000556154.1_Missense_Mutation_p.R40C|FBLN5_ENST00000342058.4_Missense_Mutation_p.R35C			Q9UBX5	FBLN5_HUMAN	fibulin 5	35					cell-matrix adhesion|elastic fiber assembly|protein localization at cell surface|regulation of removal of superoxide radicals	extracellular space|proteinaceous extracellular matrix|soluble fraction	calcium ion binding|integrin binding|protein C-terminus binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	28		all_cancers(154;0.0722)				CCTGACTGGCGATCCAGGTCA	0.483000													11	24					0	0	1	0	0
BCS1L	617	broad.mit.edu	37	2	219527664	219527664	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr2:219527664G>A	ENST00000431802.1	+	7	1647	c.948G>A	c.(946-948)ttG>ttA	p.L316L	BCS1L_ENST00000392110.2_Silent_p.L316L|BCS1L_ENST00000465706.1_3'UTR|BCS1L_ENST00000439945.1_Silent_p.L316L|BCS1L_ENST00000392111.2_Silent_p.L316L|BCS1L_ENST00000392109.1_Silent_p.L316L|BCS1L_ENST00000412366.1_Silent_p.L316L|BCS1L_ENST00000359273.3_Silent_p.L316L			Q9Y276	BCS1_HUMAN	BC1 (ubiquinol-cytochrome c reductase) synthesis-like	316					mitochondrial respiratory chain complex I assembly|mitochondrial respiratory chain complex III assembly|mitochondrial respiratory chain complex IV assembly	integral to membrane|mitochondrial respiratory chain complex III	ATP binding|nucleoside-triphosphatase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)	8		Renal(207;0.0474)		Epithelial(149;7.12e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCAATGCCTTGGATGGTGTGG	0.552000													113	29					0	0	1	0	0
CER1	9350	broad.mit.edu	37	9	14722355	14722355	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr9:14722355G>A	ENST00000380911.3	-	1	360	c.316C>T	c.(316-318)Cca>Tca	p.P106S		NM_005454.2	NP_005445.1	O95813	CER1_HUMAN	cerberus 1, DAN family BMP antagonist	106					BMP signaling pathway	extracellular space	cytokine activity			endometrium(2)|large_intestine(3)|lung(6)	11				GBM - Glioblastoma multiforme(50;3.16e-06)		GTCCCAGGTGGGAAGGGCTCA	0.507000													29	17					0	0	1	0	0
RASGEF1C	255426	broad.mit.edu	37	5	179564880	179564880	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:179564880G>A	ENST00000393371.2	-	1	469	c.173C>T	c.(172-174)cCc>cTc	p.P58L	RASGEF1C_ENST00000361132.4_Missense_Mutation_p.P58L			Q8N431	RGF1C_HUMAN	RasGEF domain family, member 1C	58	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity			breast(1)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|stomach(1)	12	all_cancers(89;3.44e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0242)|Medulloblastoma(196;0.00498)|all_neural(177;0.0137)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACCCACCTCGGGGTAGTAGTC	0.672000													14	8					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52539134	52539134	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:52539134C>T	ENST00000321725.6	+	13	1569	c.1493C>T	c.(1492-1494)cCc>cTc	p.P498L		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	498					cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		TGGCAGGCCCCCTCTGGGACC	0.612000													64	28					0	0	1	0	0
NCBP1	4686	broad.mit.edu	37	9	100405573	100405573	+	Silent	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr9:100405573T>C	ENST00000375147.3	+	4	568	c.312T>C	c.(310-312)ttT>ttC	p.F104F		NM_002486.4	NP_002477.1	Q09161	NCBP1_HUMAN	nuclear cap binding protein subunit 1, 80kDa	104	MIF4G.				gene silencing by RNA|histone mRNA metabolic process|mRNA 3'-end processing|mRNA capping|mRNA cleavage|mRNA export from nucleus|ncRNA metabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of mRNA 3'-end processing|positive regulation of viral transcription|regulation of translational initiation|spliceosomal snRNP assembly|termination of RNA polymerase II transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|mRNA cap binding complex|nucleoplasm|ribonucleoprotein complex	protein binding|RNA cap binding			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)	19		Acute lymphoblastic leukemia(62;0.158)				GTGGAGAATTTGTAGAAGCCA	0.343000													40	24					0	0	1	0	0
GLYATL1	92292	broad.mit.edu	37	11	58722282	58722282	+	Missense_Mutation	SNP	C	C	T	rs151204927		TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:58722282C>T	ENST00000300079.5	+	5	369	c.319C>T	c.(319-321)Cgt>Tgt	p.R107C	GLYATL1_ENST00000317391.4_Missense_Mutation_p.R76C|RP11-142C4.6_ENST00000533954.1_RNA	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	76						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	AAACGTATATCGTATGTTCTC	0.383000													26	52					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109689832	109689832	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr9:109689832G>A	ENST00000277225.5	+	3	3928	c.3639G>A	c.(3637-3639)caG>caA	p.Q1213Q	ZNF462_ENST00000457913.1_Silent_p.Q1213Q|ZNF462_ENST00000441147.2_Silent_p.Q58Q			Q96JM2	ZN462_HUMAN	zinc finger protein 462	1213					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						TTCATTATCAGAAGAAGCACC	0.522000													225	102					0	0	1	0	0
TGM7	116179	broad.mit.edu	37	15	43584243	43584243	+	Silent	SNP	T	T	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr15:43584243T>A	ENST00000452443.2	-	4	496	c.492A>T	c.(490-492)cgA>cgT	p.R164R		NM_052955.2	NP_443187.1	Q96PF1	TGM7_HUMAN	transglutaminase 7	164					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	AGCCATAATCTCGCATGATAT	0.493000													12	23					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9416235	9416235	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr20:9416235G>A	ENST00000378501.2	+	25	2532	c.2517G>A	c.(2515-2517)aaG>aaA	p.K839K	PLCB4_ENST00000334005.3_Silent_p.K839K|PLCB4_ENST00000278655.4_Silent_p.K839K|PLCB4_ENST00000378493.1_Silent_p.K839K|PLCB4_ENST00000378473.3_Silent_p.K851K|PLCB4_ENST00000414679.2_Silent_p.K851K|PLCB4_ENST00000492632.1_3'UTR	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	839					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity	p.K839N(1)		NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						CAGATCCAAAGAAATTTCTCT	0.363000													32	39					0	0	1	0	0
FAM90A1	55138	broad.mit.edu	37	12	8377426	8377426	+	Translation_Start_Site	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:8377426C>T	ENST00000538603.1	-	4	561	c.3G>A	c.(1-3)atG>atA	p.M1I	FAM90A1_ENST00000307435.6_Start_Codon_SNP_p.M1I	NM_018088.3	NP_060558.3	Q86YD7	F90A1_HUMAN	family with sequence similarity 90, member A1	1							nucleic acid binding|zinc ion binding			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	25				Kidney(36;0.0866)		GACGTGCCATCATCTTCGTCT	0.577000													9	18					0	0	1	0	0
C1orf159	54991	broad.mit.edu	37	1	1018301	1018301	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:1018301G>A	ENST00000448924.1	-	11	1546	c.1115C>T	c.(1114-1116)cCg>cTg	p.P372L	C1orf159_ENST00000379319.1_Missense_Mutation_p.P190L|C1orf159_ENST00000421241.2_Missense_Mutation_p.P190L|C1orf159_ENST00000294576.5_Missense_Mutation_p.P336L|C1orf159_ENST00000379339.1_Missense_Mutation_p.P372L|C1orf159_ENST00000379320.1_Missense_Mutation_p.P336L			Q96HA4	CA159_HUMAN	chromosome 1 open reading frame 159	372						integral to membrane						all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.96e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.77e-22)|Colorectal(212;6.51e-05)|COAD - Colon adenocarcinoma(227;0.000214)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|Kidney(185;0.00254)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		GGCCTCCCCCGGGAAGGCAGC	0.692000													5	9					0	0	1	0	0
JAK1	3716	broad.mit.edu	37	1	65332743	65332743	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:65332743G>A	ENST00000342505.4	-	7	1044	c.796C>T	c.(796-798)Ctg>Ttg	p.L266L		NM_002227.2	NP_002218.2	P23458	JAK1_HUMAN	Janus kinase 1	266	FERM.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(48)|kidney(3)|large_intestine(8)|liver(2)|lung(19)|ovary(1)|prostate(12)|skin(1)|soft_tissue(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	120				BRCA - Breast invasive adenocarcinoma(111;0.0485)		TTCACCTTCAGGTCATGCGTG	0.388000			Mis		ALL								31	75					0	0	1	0	0
TGM7	116179	broad.mit.edu	37	15	43584242	43584242	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr15:43584242C>A	ENST00000452443.2	-	4	497	c.493G>T	c.(493-495)Gat>Tat	p.D165Y		NM_052955.2	NP_443187.1	Q96PF1	TGM7_HUMAN	transglutaminase 7	165					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	AAGCCATAATCTCGCATGATA	0.498000													12	23					3.27435e-08	3.31758e-08	1	1	0
NSUN7	79730	broad.mit.edu	37	4	40776903	40776903	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr4:40776903C>T	ENST00000381782.2	+	6	1256	c.761C>T	c.(760-762)cCa>cTa	p.P254L	NSUN7_ENST00000316607.5_Missense_Mutation_p.P254L|NSUN7_ENST00000463952.1_3'UTR	NM_024677.4	NP_078953.3			NOP2/Sun domain family, member 7											NS(1)|autonomic_ganglia(1)|cervix(1)|large_intestine(1)|lung(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	12						TTAATTTTTCCATCTCATCTT	0.264000													12	21					0	0	1	0	0
PKD1L2	114780	broad.mit.edu	37	16	81180978	81180978	+	RNA	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:81180978C>T	ENST00000525539.1	-	0	5112				PKD1L2_ENST00000533478.1_RNA	NM_052892.3	NP_443124.3	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						AACACCTGCCCTGATGTGTTC	0.522000													70	80					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94725156	94725156	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr14:94725156G>A	ENST00000304338.3	+	18	2201	c.2047G>A	c.(2047-2049)Gat>Aat	p.D683N		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	683						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						AATGTCTATGGATGCTGTAAG	0.318000													14	8					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29812909	29812909	+	Silent	SNP	T	T	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr10:29812909T>A	ENST00000375398.2	-	17	3083	c.2634A>T	c.(2632-2634)tcA>tcT	p.S878S	SVIL_ENST00000355867.4_Silent_p.S878S|SVIL_ENST00000375400.3_Silent_p.S452S			O95425	SVIL_HUMAN	supervillin	878					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				CGGTAGACACTGATGTGTTCA	0.438000													20	34					0	0	1	0	0
TRA2B	6434	broad.mit.edu	37	3	185643307	185643307	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:185643307C>T	ENST00000453386.2	-	3	553	c.278G>A	c.(277-279)cGg>cAg	p.R93Q	TRA2B_ENST00000382191.4_5'UTR	NM_004593.2	NP_004584.1	P62995	TRA2B_HUMAN	transformer 2 beta homolog (Drosophila)	93	Arg/Ser-rich (RS1 domain).				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|protein binding|RNA binding			breast(2)|kidney(1)|large_intestine(6)|lung(4)|ovary(3)|prostate(1)|urinary_tract(1)	18						GTGGCTGTGCCGTCTACGATA	0.507000													44	46					0	0	1	0	0
KCNAB3	9196	broad.mit.edu	37	17	7827358	7827358	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:7827358G>A	ENST00000303790.2	-	11	854	c.855C>T	c.(853-855)taC>taT	p.Y285Y		NM_004732.3	NP_004723.2	O43448	KCAB3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, beta member 3	285						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(2)|endometrium(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)	8		Prostate(122;0.157)				AGGCTAGAGGGTACCAAGTGA	0.542000													13	25					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13419282	13419282	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:13419282C>T	ENST00000360228.5	-	13	1728	c.1729G>A	c.(1729-1731)Gga>Aga	p.G577R	CACNA1A_ENST00000573710.2_Missense_Mutation_p.G578R	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	578					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	ACGCTGATTCCAAAGGATGTG	0.502000													9	27					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40827991	40827991	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr20:40827991C>T	ENST00000373198.3	-	17	2681	c.2446G>A	c.(2446-2448)Gcc>Acc	p.A816T	PTPRT_ENST00000373190.1_Missense_Mutation_p.A794T|PTPRT_ENST00000373193.3_Missense_Mutation_p.A797T|PTPRT_ENST00000356100.2_Missense_Mutation_p.A803T|PTPRT_ENST00000373187.1_Missense_Mutation_p.A794T|PTPRT_ENST00000373201.1_Missense_Mutation_p.A784T|PTPRT_ENST00000373184.1_Missense_Mutation_p.A784T	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	794					homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TCCCTCTGGGCTCCACTCTGG	0.552000													4	205					0	0	1	0	0
LOC653786	653786	broad.mit.edu	37	16	22558351	22558351	+	RNA	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:22558351G>A	ENST00000550753.1	+	0	1333					NR_003676.2																						TTTCTCAGGAGATGAATTAAG	0.423000													4	70					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113169455	113169455	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr9:113169455C>T	ENST00000401783.2	-	38	8761	c.8425G>A	c.(8425-8427)Ggc>Agc	p.G2809S	SVEP1_ENST00000297826.5_Missense_Mutation_p.G735S|SVEP1_ENST00000374469.1_Missense_Mutation_p.G2786S	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2809	Sushi 23.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CTCTCAGTGCCATTCAGCACA	0.488000													11	72					0	0	1	0	0
ANO1	55107	broad.mit.edu	37	11	70007324	70007324	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:70007324G>C	ENST00000355303.5	+	17	1941	c.1636G>C	c.(1636-1638)Gcc>Ccc	p.A546P	ANO1_ENST00000398543.2_Missense_Mutation_p.A400P|ANO1_ENST00000531349.1_Missense_Mutation_p.A255P|ANO1_ENST00000530676.1_Missense_Mutation_p.A400P|ANO1_ENST00000538023.1_Missense_Mutation_p.A546P|ANO1_ENST00000316296.5_Missense_Mutation_p.A488P	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	546					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						CTCCATGGCCGCCGCCTTGGC	0.602000													33	28					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7724583	7724583	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:7724583G>T	ENST00000572933.1	+	73	12498	c.11038G>T	c.(11038-11040)Gaa>Taa	p.E3680*	DNAH2_ENST00000389173.2_Nonsense_Mutation_p.E3680*			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	3680					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TACCCTTTTCGAACGCCACAA	0.498000													49	87					8.28887e-21	8.48227e-21	1	1	0
DNAH10	196385	broad.mit.edu	37	12	124359953	124359953	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:124359953C>T	ENST00000409039.3	+	46	7785	c.7760C>T	c.(7759-7761)tCg>tTg	p.S2587L		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2587	AAA 3 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.S1179L(1)|p.S2587L(1)		breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AGATTTATTTCGCTATTCAGT	0.443000													17	37					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24193170	24193170	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr8:24193170C>T	ENST00000437154.2	+	14	1622	c.1583C>T	c.(1582-1584)cCt>cTt	p.P528L	ADAM28_ENST00000540823.1_Missense_Mutation_p.P295L|RP11-624C23.1_ENST00000519689.1_RNA|RP11-624C23.1_ENST00000518988.1_RNA|ADAM28_ENST00000265769.4_Intron|ADAM28_ENST00000397649.3_Intron|RP11-624C23.1_ENST00000523700.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA	NM_021777.3	NP_068547.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	528	Cys-rich.				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		AGGACAAATCCTTTCCCCTGT	0.512000													5	4					0	0	1	0	0
CRY2	1408	broad.mit.edu	37	11	45868998	45868998	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:45868998C>T	ENST00000443527.2	+	1	42	c.20C>T	c.(19-21)gCc>gTc	p.A7V	CRY2_ENST00000417225.2_Intron	NM_021117.3	NP_066940.2	Q49AN0	CRY2_HUMAN	cryptochrome 2 (photolyase-like)	0					DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	blue light photoreceptor activity|damaged DNA binding|DNA photolyase activity|nucleotide binding|protein binding|single-stranded DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(2)	15						GTCCACGTCGCCTACCGGGGC	0.731000													18	24					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	7009357	7009357	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr18:7009357C>T	ENST00000389658.3	-	27	3975	c.3882G>A	c.(3880-3882)tgG>tgA	p.W1294*		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	1294	Laminin IV type A 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TAAAATATTTCCAAAAATTCT	0.343000													12	31					0	0	1	0	0
UNC93B1	81622	broad.mit.edu	37	11	67767085	67767085	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:67767085T>C	ENST00000227471.2	-	4	537	c.458A>G	c.(457-459)aAc>aGc	p.N153S	UNC93B1_ENST00000530331.1_5'UTR	NM_030930.2	NP_112192.2	Q9H1C4	UN93B_HUMAN	unc-93 homolog B1 (C. elegans)	153					innate immune response|intracellular protein transport|response to virus|toll-like receptor 3 signaling pathway|toll-like receptor 7 signaling pathway|toll-like receptor 9 signaling pathway	early phagosome|endoplasmic reticulum membrane|endosome|integral to membrane|lysosome											CTCCCAGTAGTTGGTGGAGAC	0.582000													7	16					0	0	1	0	0
NT5DC2	64943	broad.mit.edu	37	3	52562323	52562323	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:52562323G>A	ENST00000307076.4	-	6	936	c.536C>T	c.(535-537)cCc>cTc	p.P179L	NT5DC2_ENST00000459839.1_Missense_Mutation_p.P191L|NT5DC2_ENST00000422318.2_Missense_Mutation_p.P216L|NT5DC2_ENST00000307092.4_Missense_Mutation_p.P120L	NM_022908.2	NP_075059.1	Q9H857	NT5D2_HUMAN	5'-nucleotidase domain containing 2	179							hydrolase activity|metal ion binding			endometrium(1)|lung(3)|prostate(1)|stomach(1)	6				BRCA - Breast invasive adenocarcinoma(193;1.7e-05)|Kidney(197;0.00177)|KIRC - Kidney renal clear cell carcinoma(197;0.002)|OV - Ovarian serous cystadenocarcinoma(275;0.0476)		CTTAATGGAGGGACCCTGGGG	0.582000													28	13					0	0	1	0	0
ZNF438	220929	broad.mit.edu	37	10	31137582	31137582	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr10:31137582G>A	ENST00000538351.1	-	7	2359	c.1605C>T	c.(1603-1605)ggC>ggT	p.G535G	ZNF438_ENST00000442986.1_Silent_p.G584G|ZNF438_ENST00000375311.1_Silent_p.G148G|ZNF438_ENST00000413025.1_Silent_p.G584G|ZNF438_ENST00000331737.6_Silent_p.G574G|ZNF438_ENST00000452305.1_Silent_p.G574G|ZNF438_ENST00000444692.2_Silent_p.G574G|ZNF438_ENST00000361310.3_Silent_p.G584G|ZNF438_ENST00000436087.2_Silent_p.G584G	NM_001143769.1	NP_001137241.1	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438	584					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(15)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(175;0.0587)				CTTTCAGATGGCCAAAATAGA	0.478000													4	87					0	0	1	0	0
METTL7A	25840	broad.mit.edu	37	12	51318957	51318957	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:51318957A>T	ENST00000548553.1	+	2	1117	c.136A>T	c.(136-138)Ata>Tta	p.I46L	METTL7A_ENST00000332160.4_Missense_Mutation_p.I46L			Q9H8H3	MET7A_HUMAN	methyltransferase like 7A	46						endoplasmic reticulum|lipid particle|membrane	methyltransferase activity			endometrium(1)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)	10						GTTCACTGTGATATACAACGA	0.512000													39	55					0	0	1	0	0
WT1	7490	broad.mit.edu	37	11	32439182	32439182	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:32439182C>T	ENST00000332351.3	-	4	1175	c.891G>A	c.(889-891)atG>atA	p.M297I	WT1_ENST00000530998.1_Missense_Mutation_p.M85I|WT1_ENST00000448076.3_Missense_Mutation_p.M297I|WT1_ENST00000379079.2_Missense_Mutation_p.M85I	NM_024424.3|NM_024426.4	NP_077742.2|NP_077744.3	P19544	WT1_HUMAN	Wilms tumor 1	229					adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding		EWSR1/WT1(234)	NS(1)|haematopoietic_and_lymphoid_tissue(348)|kidney(149)|large_intestine(9)|lung(20)|peritoneum(1)|pleura(2)|skin(2)|upper_aerodigestive_tract(1)	533	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			GCTGGGATGTCATTTGGTATA	0.358000			"""D, Mis, N, F, S"""	EWSR1	"""Wilms, desmoplastic small round cell tumor"""	Wilms			Wilms' tumor-Aniridia-ambiguous Genitals-mental Retardation;Frasier syndrome;Familial Wilms' tumor;Denys-Drash syndrome				17	31					0	0	1	0	0
WDR59	79726	broad.mit.edu	37	16	74955968	74955968	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:74955968G>A	ENST00000262144.6	-	10	893	c.763C>T	c.(763-765)Ccc>Tcc	p.P255S		NM_030581.3	NP_085058.3	Q6PJI9	WDR59_HUMAN	WD repeat domain 59	255										breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)	27						CGCAGCTGGGGAACCATCACA	0.498000													21	59					0	0	1	0	0
LSS	4047	broad.mit.edu	37	21	47626600	47626600	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr21:47626600G>A	ENST00000397728.3	-	16	1628	c.1550C>T	c.(1549-1551)cCc>cTc	p.P517L	LSS_ENST00000522411.1_Missense_Mutation_p.P506L|LSS_ENST00000457828.2_Missense_Mutation_p.P437L|LSS_ENST00000356396.4_Missense_Mutation_p.P517L	NM_001145436.1|NM_002340.5	NP_001138908.1|NP_002331.3	P48449	ERG7_HUMAN	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	517					cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity			cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|skin(1)|urinary_tract(1)	21	Breast(49;0.214)					GACCTCCGAGGGGTTCAGCAG	0.607000													20	44					0	0	1	0	0
RFX3	5991	broad.mit.edu	37	9	3288164	3288164	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr9:3288164G>A	ENST00000382004.3	-	8	1129	c.818C>T	c.(817-819)gCt>gTt	p.A273V	RFX3_ENST00000358730.2_Missense_Mutation_p.A273V|RFX3_ENST00000302303.1_Missense_Mutation_p.A273V	NM_134428.1	NP_602304.1	P48380	RFX3_HUMAN	regulatory factor X, 3 (influences HLA class II expression)	273					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(11)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		TTGTCTCATAGCCATATACTG	0.403000													22	8					0	0	1	0	0
GSE1	23199	broad.mit.edu	37	16	85696634	85696634	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:85696634G>A	ENST00000253458.7	+	10	2484	c.2308G>A	c.(2308-2310)Gag>Aag	p.E770K	GSE1_ENST00000405402.2_Missense_Mutation_p.E666K|GSE1_ENST00000393243.1_Missense_Mutation_p.E697K	NM_014615.2	NP_055430.1			Gse1 coiled-coil protein																		CGATGAGGAGGAGGTCAGGGC	0.582000													27	41					0	0	1	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161017885	161017885	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:161017885C>T	ENST00000368013.3	-	12	3246	c.2926G>A	c.(2926-2928)Gga>Aga	p.G976R	ARHGAP30_ENST00000368016.3_Missense_Mutation_p.G765R|ARHGAP30_ENST00000368015.1_Missense_Mutation_p.G799R	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	976					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			GCCCTTTCTCCAGGAGTCCCA	0.582000													70	95					0	0	1	0	0
TM9SF1	10548	broad.mit.edu	37	14	24679650	24679650	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr14:24679650C>T	ENST00000530611.1	-	5	547	c.514G>A	c.(514-516)Gaa>Aaa	p.E172K	AL136419.6_ENST00000565988.1_RNA|CHMP4A_ENST00000542700.2_5'UTR|CHMP4A_ENST00000347519.6_Missense_Mutation_p.E215K|TM9SF1_ENST00000556387.1_Missense_Mutation_p.E172K			O15321	TM9S1_HUMAN	transmembrane 9 superfamily member 1	0					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				NS(1)|breast(4)|endometrium(3)|large_intestine(11)|lung(4)|ovary(1)	24				GBM - Glioblastoma multiforme(265;0.0183)		TGGGCCAATTCCTCCTGCTCC	0.478000													90	164					0	0	1	0	0
RAPGEF5	9771	broad.mit.edu	37	7	22162108	22162108	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:22162108T>A	ENST00000344041.6	-	26	2421	c.2109A>T	c.(2107-2109)ttA>ttT	p.L703F	RAPGEF5_ENST00000401957.2_Missense_Mutation_p.L553F	NM_012294.3	NP_036426.3	Q92565	RPGF5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 5	553					nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(2)|ovary(1)	6						CATAGGACTTTAACTCTTGAT	0.473000													14	28					0	0	1	0	0
PIK3R6	146850	broad.mit.edu	37	17	8738761	8738761	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:8738761G>A	ENST00000311434.9	-	8	713	c.474C>T	c.(472-474)ttC>ttT	p.F158F	PIK3R6_ENST00000434064.2_5'UTR	NM_001010855.2	NP_001010855.1	Q5UE93	PI3R6_HUMAN	phosphoinositide-3-kinase, regulatory subunit 6	158					platelet activation	cytosol											CAGGATCCACGAAGAGGAACA	0.612000													24	27					0	0	1	0	0
KIR3DL2	3812	broad.mit.edu	37	19	55377343	55377343	+	Missense_Mutation	SNP	C	C	T	rs138402445		TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:55377343C>T	ENST00000326321.3	+	7	1117	c.1084C>T	c.(1084-1086)Cgc>Tgc	p.R362C	KIR3DL1_ENST00000402254.2_Missense_Mutation_p.R362C|KIR3DL2_ENST00000270442.5_Missense_Mutation_p.R345C	NM_006737.3	NP_006728.2	P43630	KI3L2_HUMAN	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	362					cellular defense response|regulation of immune response	integral to plasma membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	23				GBM - Glioblastoma multiforme(193;0.0192)		tctcctTTATCGCTGGTGCTC	0.532000													9	18					0	0	1	0	0
EPAS1	2034	broad.mit.edu	37	2	46609576	46609576	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr2:46609576A>C	ENST00000263734.3	+	15	2810	c.2300A>C	c.(2299-2301)cAa>cCa	p.Q767P		NM_001430.4	NP_001421.2	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	767					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			AAGTTCACCCAAAACCCCATG	0.572000													4	150					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100133713	100133713	+	Nonstop_Mutation	SNP	T	T	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr8:100133713T>A	ENST00000441350.2	+	8	1349	c.1246T>A	c.(1246-1248)Taa>Aaa	p.*416K	VPS13B_ENST00000395996.1_Intron|VPS13B_ENST00000358544.2_Intron|VPS13B_ENST00000355155.1_Intron|VPS13B_ENST00000357162.2_Intron	NM_181661.2	NP_858047.2	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	0					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CTATCAACTTTAATGCTTAAA	0.318000													17	34					0	0	1	0	0
PRR23B	389151	broad.mit.edu	37	3	138738999	138738999	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:138738999C>T	ENST00000329447.5	-	1	769	c.505G>A	c.(505-507)Gac>Aac	p.D169N	MRPS22_ENST00000495075.1_Intron	NM_001013650.2	NP_001013672.1	Q6ZRT6	PR23B_HUMAN	proline rich 23B	169										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GTTGGGGAGTCCATCCGGAGC	0.657000													28	35					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31326362	31326362	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr18:31326362C>T	ENST00000269197.5	+	12	6550	c.6550C>T	c.(6550-6552)Cct>Tct	p.P2184S		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	2184					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						TGGCTCCAATCCTGCCACAGG	0.478000													52	82					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	151090363	151090363	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:151090363A>G	ENST00000474524.1	+	25	3606	c.3568A>G	c.(3568-3570)Aaa>Gaa	p.K1190E	P2RY12_ENST00000302632.3_Intron|MED12L_ENST00000273432.4_Missense_Mutation_p.K1050E	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	1190					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AGGAGATGCCAAAATTGGCAA	0.378000													31	43					0	0	1	0	0
PRB4	5545	broad.mit.edu	37	12	11461319	11461319	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:11461319G>A	ENST00000279575.1	-	3	631	c.598C>T	c.(598-600)Cct>Tct	p.P200S	PRB4_ENST00000445719.2_Missense_Mutation_p.P131S|PRB4_ENST00000535904.1_Missense_Mutation_p.P200S	NM_001261399.1|NM_002723.4	NP_001248328.1|NP_002714.2	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	263	9.5 X 21 AA tandem repeats of K-P-[EQ]- [GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]- [RG]-[PT]-P-P-[PH]-P-G.		P -> H (in dbSNP:rs12308244).			extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|skin(4)|upper_aerodigestive_tract(3)	30						GGCTTTCCAGGAGGTGGGGGA	0.627000										HNSCC(22;0.051)			153	197					0	0	1	0	0
CST5	1473	broad.mit.edu	37	20	23858220	23858220	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr20:23858220C>T	ENST00000304710.4	-	2	340	c.267G>A	c.(265-267)aaG>aaA	p.K89K		NM_001900.4	NP_001891.2	P28325	CYTD_HUMAN	cystatin D	89						extracellular region	cysteine-type endopeptidase inhibitor activity|protein binding			breast(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)|stomach(1)	11						TTCGACCGAACTTCACATTGA	0.532000													50	57					0	0	1	0	0
HMGXB4	10042	broad.mit.edu	37	22	35661213	35661213	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr22:35661213C>G	ENST00000216106.5	+	5	960	c.832C>G	c.(832-834)Cac>Gac	p.H278D	HMGXB4_ENST00000444518.2_Missense_Mutation_p.H169D	NM_001003681.2	NP_001003681.1	Q9UGU5	HMGX4_HUMAN	HMG box domain containing 4	278					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|endometrium(1)|large_intestine(6)|liver(1)|lung(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CGCAGAGTCCCACAGTGCTAA	0.517000													26	40					0	0	1	0	0
OR2T4	127074	broad.mit.edu	37	1	248525786	248525786	+	Nonsense_Mutation	SNP	A	A	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:248525786A>T	ENST00000366475.1	+	1	904	c.904A>T	c.(904-906)Aag>Tag	p.K302*		NM_001004696.1	NP_001004696.1	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T, member 4	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|liver(2)|lung(47)	56	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CACCCCTGAGAAGGACATGAT	0.512000													75	110					0	0	1	0	0
LGI4	163175	broad.mit.edu	37	19	35616208	35616208	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:35616208G>A	ENST00000310123.3	-	9	2022	c.1503C>T	c.(1501-1503)gcC>gcT	p.A501A	LGI4_ENST00000493050.1_5'UTR|LGI4_ENST00000392225.3_3'UTR	NM_139284.2	NP_644813.1	Q8N135	LGI4_HUMAN	leucine-rich repeat LGI family, member 4	501						extracellular region				endometrium(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.54e-20)|OV - Ovarian serous cystadenocarcinoma(14;1.33e-18)|all cancers(14;4.27e-17)|LUSC - Lung squamous cell carcinoma(66;0.0849)			AGGCACGGGGGGCCACCAGGG	0.637000													36	39					0	0	1	0	0
DIP2B	57609	broad.mit.edu	37	12	51128913	51128913	+	Splice_Site	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:51128913G>A	ENST00000301180.5	+	34	4135	c.4101_splice	c.e34+1	p.K1367_splice		NM_173602.2	NP_775873.2	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B (Drosophila)	1367						nucleus	catalytic activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(15)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	60						AGTCTGGAAAGGTAATTTGTT	0.458000											OREG0021816	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	62					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196722110	196722110	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr2:196722110G>A	ENST00000312428.6	-	44	8505	c.8405C>T	c.(8404-8406)tCa>tTa	p.S2802L		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2802	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						CTTATCATATGAATCCATTGC	0.343000													30	15					0	0	1	0	0
GHRHR	2692	broad.mit.edu	37	7	31016150	31016150	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:31016150G>A	ENST00000409904.3	+	8	1147	c.889G>A	c.(889-891)Gag>Aag	p.E297K	GHRHR_ENST00000326139.2_Missense_Mutation_p.E361K|GHRHR_ENST00000409316.1_Missense_Mutation_p.G127E|GHRHR_ENST00000461424.1_3'UTR			Q02643	GHRHR_HUMAN	growth hormone releasing hormone receptor	361					activation of adenylate cyclase activity by G-protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to estrogen stimulus|response to glucocorticoid stimulus	cell surface|integral to membrane|nuclear inner membrane|nuclear matrix|nuclear outer membrane|plasma membrane|stored secretory granule	growth factor binding|growth hormone-releasing hormone receptor activity|peptide hormone binding			biliary_tract(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(18)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35					Sermorelin(DB00010)	CCTCCCCCTGGAGCTGGGACT	0.582000													6	14					0	0	1	0	0
BAI1	575	broad.mit.edu	37	8	143562694	143562694	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr8:143562694C>T	ENST00000517894.1	+	10	2802	c.1908C>T	c.(1906-1908)tcC>tcT	p.S636S	BAI1_ENST00000323289.5_Silent_p.S636S			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	636					axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GCTGTGTTTCCATTGACTACA	0.607000													30	51					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	79432556	79432556	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr14:79432556C>T	ENST00000554719.1	+	9	1956	c.1465C>T	c.(1465-1467)Cgt>Tgt	p.R489C	NRXN3_ENST00000335750.5_Missense_Mutation_p.R489C	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	0					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GCTGAAGGCTCGTTTTGGACT	0.478000													28	35					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216538337	216538337	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:216538337C>T	ENST00000366943.2	-	4	1128	c.742G>A	c.(742-744)Gat>Aat	p.D248N	USH2A_ENST00000307340.3_Missense_Mutation_p.D248N|USH2A_ENST00000366942.3_Missense_Mutation_p.D248N			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	248					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GATGCAAAATCTGTAATTGAA	0.338000										HNSCC(13;0.011)			19	28					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713845	142713845	+	RNA	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:142713845C>T	ENST00000369381.2	-	0	760																											CAATTTTCATCCATCAGATCT	0.284000													13	15					0	0	1	0	0
SLC22A9	114571	broad.mit.edu	37	11	63137793	63137793	+	Missense_Mutation	SNP	C	C	T	rs143461929	by1000genomes	TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:63137793C>T	ENST00000279178.3	+	1	514	c.265C>T	c.(265-267)Cgt>Tgt	p.R89C	SLC22A9_ENST00000310969.4_Missense_Mutation_p.R89C	NM_080866.2	NP_543142.2	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion transporter), member 9	89					transmembrane transport	integral to membrane				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	18						AGAGAAGTGTCGTCGCTTTGT	0.537000													33	66					0	0	1	0	0
SLC39A10	57181	broad.mit.edu	37	2	196545449	196545449	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr2:196545449T>C	ENST00000409086.3	+	2	958	c.683T>C	c.(682-684)cTa>cCa	p.L228P	SLC39A10_ENST00000541054.1_Intron|SLC39A10_ENST00000359634.5_Missense_Mutation_p.L228P	NM_001127257.1	NP_001120729.1	Q9ULF5	S39AA_HUMAN	solute carrier family 39 (zinc transporter), member 10	228					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(16)|pancreas(1)|prostate(1)|skin(2)	34			OV - Ovarian serous cystadenocarcinoma(117;0.221)			GATGTTAAACTACCGAAAGGA	0.408000													18	40					0	0	1	0	0
GPC6	10082	broad.mit.edu	37	13	94482653	94482653	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr13:94482653G>T	ENST00000377047.4	+	3	1181	c.566G>T	c.(565-567)tGt>tTt	p.C189F	GPC6-AS2_ENST00000445540.1_RNA	NM_005708.3	NP_005699.1	Q9Y625	GPC6_HUMAN	glypican 6	189						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	38	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				TACCTGGAATGTGTGAGCAAA	0.498000													40	15					3.77016e-25	3.86457e-25	1	1	0
SECISBP2	79048	broad.mit.edu	37	9	91949501	91949501	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr9:91949501C>T	ENST00000375807.3	+	7	1016	c.945C>T	c.(943-945)gcC>gcT	p.A315A	SECISBP2_ENST00000534113.2_Silent_p.A247A|SECISBP2_ENST00000339901.4_Silent_p.A242A	NM_024077.3	NP_076982.3	Q96T21	SEBP2_HUMAN	SECIS binding protein 2	315					translation	nucleus	mRNA 3'-UTR binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(3)|skin(2)	32						TGTCAGCAGCCCCTAAAAATG	0.363000													17	4					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168100111	168100111	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr2:168100111G>A	ENST00000409195.1	+	9	2298	c.2209G>A	c.(2209-2211)Gaa>Aaa	p.E737K	XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.E737K|XIRP2_ENST00000409273.1_Missense_Mutation_p.E515K|XIRP2_ENST00000409605.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	562					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AAAATGTTTCGAAACTCAACC	0.373000													36	12					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25444440	25444440	+	RNA	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr15:25444440C>T	ENST00000424208.1	+	0	1713				SNHG14_ENST00000424333.1_RNA	NR_003305.1																						TTGCATTGGGCCCAATGGACC	0.592000													16	24					0	0	1	0	0
FAM120C	54954	broad.mit.edu	37	X	54107879	54107879	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chrX:54107879G>A	ENST00000375180.2	-	14	2910	c.2854C>T	c.(2854-2856)Cca>Tca	p.P952S	FAM120C_ENST00000328235.4_Silent_p.S814S	NM_017848.4	NP_060318.3	Q9NX05	F120C_HUMAN	family with sequence similarity 120C	952										breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						CCTTGGGGTGGGATTGGATGG	0.572000													22	7					0	0	1	0	0
SCNN1B	6338	broad.mit.edu	37	16	23364245	23364245	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:23364245G>A	ENST00000343070.2	+	3	611	c.435G>A	c.(433-435)tgG>tgA	p.W145*	SCNN1B_ENST00000307331.5_Nonsense_Mutation_p.W190*|SCNN1B_ENST00000568923.1_Nonsense_Mutation_p.W145*|SCNN1B_ENST00000568085.1_Nonsense_Mutation_p.W145*	NM_000336.2	NP_000327.2	P51168	SCNNB_HUMAN	sodium channel, non-voltage-gated 1, beta subunit	145					excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	32				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	TCTCCATCTGGAACCACACAC	0.532000													52	66					0	0	1	0	0
WRN	7486	broad.mit.edu	37	8	30942717	30942717	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr8:30942717C>T	ENST00000298139.5	+	11	1635	c.1386C>T	c.(1384-1386)tcC>tcT	p.S462S		NM_000553.4	NP_000544.2	Q14191	WRN_HUMAN	Werner syndrome, RecQ helicase-like	462	2 X 27 AA tandem repeats of H-L-S-P-N-D- N-E-N-D-T-S-Y-V-I-E-S-D-E-D-L-E-M-E-M-L- K.				base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(13)|lung(28)|ovary(3)|skin(3)|upper_aerodigestive_tract(3)	60		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		ACGATACGTCCTATGTAATTG	0.279000			"""Mis, N, F, S"""			"""osteosarcoma, meningioma, others"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Werner syndrome				15	39					0	0	1	0	0
MCTP1	79772	broad.mit.edu	37	5	94206163	94206163	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:94206163C>T	ENST00000515393.1	-	16	2274	c.2275G>A	c.(2275-2277)Gaa>Aaa	p.E759K	MCTP1_ENST00000505078.1_Missense_Mutation_p.E275K|MCTP1_ENST00000505208.1_Missense_Mutation_p.E538K|MCTP1_ENST00000312216.8_Missense_Mutation_p.E538K|MCTP1_ENST00000429576.2_Missense_Mutation_p.E492K	NM_024717.4	NP_078993.4	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1	759					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		TACTTCTGTTCTTTGGGTATT	0.338000													20	5					0	0	1	0	0
CHRM5	1133	broad.mit.edu	37	15	34355398	34355398	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr15:34355398C>T	ENST00000383263.5	+	3	1150	c.480C>T	c.(478-480)atC>atT	p.I160I	CHRM5_ENST00000557872.1_Silent_p.I160I	NM_012125.3	NP_036257.1	P08912	ACM5_HUMAN	cholinergic receptor, muscarinic 5	160					cell proliferation|inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|skin(1)	20		all_lung(180;1.76e-08)		all cancers(64;4.82e-17)|GBM - Glioblastoma multiforme(113;2.58e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0262)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)	TCTCCTTCATCCTCTGGGCCC	0.542000													49	75					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140731360	140731360	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:140731360C>T	ENST00000523390.1	+	1	1533	c.1533C>T	c.(1531-1533)ttC>ttT	p.F511F	PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGTGGTGTTCGCGCAGCGCG	0.682000													46	22					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34191037	34191037	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:34191037A>G	ENST00000373381.4	-	17	2784	c.2608T>C	c.(2608-2610)Ttc>Ctc	p.F870L		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	830	Sushi 5.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CTGATGAGGAACTGGGGAACC	0.552000													21	30					0	0	1	0	0
ZSWIM5	57643	broad.mit.edu	37	1	45484500	45484500	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:45484500G>A	ENST00000359600.5	-	14	3389	c.3184C>T	c.(3184-3186)Ccc>Tcc	p.P1062S		NM_020883.1	NP_065934.1	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM-type containing 5	1062							zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|liver(1)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	28	Acute lymphoblastic leukemia(166;0.155)					ACCACCAGGGGGATGAGAGCT	0.597000											OREG0013450	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	53					0	0	1	0	0
ORC1	4998	broad.mit.edu	37	1	52867040	52867040	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:52867040C>T	ENST00000371568.3	-	3	435	c.217G>A	c.(217-219)Gaa>Aaa	p.E73K	ORC1_ENST00000371566.1_Missense_Mutation_p.E73K	NM_001190818.1|NM_001190819.1|NM_004153.3	NP_001177747.1|NP_001177748.1|NP_004144.2	Q13415	ORC1_HUMAN	origin recognition complex, subunit 1	73	BAH.				cell cycle checkpoint|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nuclear origin of replication recognition complex|nucleolus|nucleoplasm|plasma membrane	ATP binding|DNA binding|nucleoside-triphosphatase activity|protein binding			breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						TCACCATCTTCGAACAACTCA	0.433000													53	95					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102510944	102510944	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr14:102510944T>A	ENST00000360184.4	+	72	13079	c.12915T>A	c.(12913-12915)ttT>ttA	p.F4305L	RP11-1017G21.4_ENST00000553701.1_RNA|RP11-1017G21.4_ENST00000557242.1_RNA	NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	4305					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						GAGAGGAGTTTGTGCAGTGGG	0.577000													71	85					0	0	1	0	0
CATSPERB	79820	broad.mit.edu	37	14	92091263	92091263	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr14:92091263G>A	ENST00000256343.3	-	18	1987	c.1831C>T	c.(1831-1833)Ccc>Tcc	p.P611S		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	611					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				AATCCAAAGGGCTCTTTCATT	0.353000													13	23					0	0	1	0	0
NOL8	55035	broad.mit.edu	37	9	95077871	95077871	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr9:95077871G>A	ENST00000545558.1	-	7	1528	c.1036C>T	c.(1036-1038)Cac>Tac	p.H346Y	NOL8_ENST00000358855.4_Missense_Mutation_p.H278Y|NOL8_ENST00000535387.1_Missense_Mutation_p.H346Y|NOL8_ENST00000442668.2_Missense_Mutation_p.H346Y|NOL8_ENST00000542053.1_Missense_Mutation_p.H278Y			Q76FK4	NOL8_HUMAN	nucleolar protein 8	346					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)	16						TGCAGTTTGTGAACGCCTGAT	0.363000													8	8					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39525647	39525647	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr8:39525647G>A	ENST00000265707.5	+	14	1502	c.1457G>A	c.(1456-1458)gGa>gAa	p.G486E	ADAM18_ENST00000379866.1_Missense_Mutation_p.G462E|ADAM18_ENST00000541111.1_5'UTR	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	486	Cys-rich.				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding	p.G486V(1)		NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			TGCAAGTTGGGAACTGCCTAT	0.383000													53	90					0	0	1	0	0
AKAP8L	26993	broad.mit.edu	37	19	15491368	15491368	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:15491368T>C	ENST00000397410.4	-	13	1656	c.1592A>G	c.(1591-1593)aAc>aGc	p.N531S	AC005785.2_ENST00000597164.1_RNA|AKAP8L_ENST00000595465.1_Missense_Mutation_p.N470S	NM_014371.2	NP_055186.2	Q9ULX6	AKP8L_HUMAN	A kinase (PRKA) anchor protein 8-like	531						cytoplasm|nuclear matrix	DEAD/H-box RNA helicase binding|DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	11						GAGCTTGTTGTTGAGAATACT	0.622000													21	29					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16860407	16860407	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:16860407C>T	ENST00000524140.2	+	6	1372	c.954C>T	c.(952-954)ctC>ctT	p.L318L	NWD1_ENST00000339803.6_Silent_p.L183L|NWD1_ENST00000379808.3_Silent_p.L318L|NWD1_ENST00000552788.1_Silent_p.L318L|NWD1_ENST00000549814.1_Silent_p.L318L|NWD1_ENST00000523826.1_Silent_p.L112L	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	318							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GCCAGGAACTCCTGGCCCGGC	0.617000													37	55					0	0	1	0	0
CFAP54	144535	broad.mit.edu	37	12	97136260	97136260	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:97136260C>T	ENST00000524981.3	+	19	2468	c.2468C>T	c.(2467-2469)tCc>tTc	p.S823F				Q6ZTY8	CL063_HUMAN		797										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						GATCCTATTTCCCTAAATGCC	0.368000													3	11					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9047696	9047696	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:9047696G>A	ENST00000397910.4	-	5	34138	c.33935C>T	c.(33934-33936)tCa>tTa	p.S11312L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11314	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TATACCAGGTGAAATAGTTGT	0.483000													20	54					0	0	1	0	0
CHD9	80205	broad.mit.edu	37	16	53262897	53262897	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:53262897C>T	ENST00000566029.1	+	8	2380	c.2171C>T	c.(2170-2172)tCc>tTc	p.S724F	CHD9_ENST00000564845.1_Missense_Mutation_p.S724F|CHD9_ENST00000447540.1_Missense_Mutation_p.S724F|CHD9_ENST00000398510.3_Missense_Mutation_p.S724F			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	724	Chromo 1.				cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				aattttaGCTCCTATCTTCAC	0.308000													4	9					0	0	1	0	0
ASPH	444	broad.mit.edu	37	8	62479788	62479788	+	Silent	SNP	A	A	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr8:62479788A>G	ENST00000541428.1	-	17	1312	c.1152T>C	c.(1150-1152)gaT>gaC	p.D384D	ASPH_ENST00000379454.4_Silent_p.D413D	NM_001164750.1	NP_001158222.1	Q12797	ASPH_HUMAN	aspartate beta-hydroxylase	413					muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			breast(1)|cervix(1)|endometrium(5)|large_intestine(5)|lung(16)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)	CTGCAGGGACATCAGGTAGGC	0.483000													33	46					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62018539	62018539	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:62018539C>T	ENST00000578147.1	-	24	5179	c.5103G>A	c.(5101-5103)atG>atA	p.M1701I	SCN4A_ENST00000435607.1_Missense_Mutation_p.M1701I			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1701					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	ACTTCTCCTCCATGGTCTGCT	0.587000													26	52					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128643452	128643452	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr6:128643452G>A	ENST00000368227.3	-	3	593	c.227C>T	c.(226-228)tCc>tTc	p.S76F	PTPRK_ENST00000368210.3_Missense_Mutation_p.S76F|PTPRK_ENST00000368215.3_Missense_Mutation_p.S76F|PTPRK_ENST00000368207.3_Missense_Mutation_p.S76F|PTPRK_ENST00000524481.1_5'UTR|PTPRK_ENST00000368213.5_Missense_Mutation_p.S76F|PTPRK_ENST00000525459.1_Missense_Mutation_p.S76F|PTPRK_ENST00000368226.4_Missense_Mutation_p.S76F|PTPRK_ENST00000532331.1_Missense_Mutation_p.S76F			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	76	MAM.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TATCATATAGGAACCTGAAAT	0.353000													28	24					0	0	1	0	0
OR5AK2	390181	broad.mit.edu	37	11	56757252	56757252	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:56757252A>T	ENST00000326855.2	+	1	906	c.864A>T	c.(862-864)ttA>ttT	p.L288F		NM_001005323.1	NP_001005323.1	Q8NH90	O5AK2_HUMAN	olfactory receptor, family 5, subfamily AK, member 2	288					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	21						TAAATCCTTTAATCTATAGCT	0.308000													9	18					0	0	1	0	0
OR4A47	403253	broad.mit.edu	37	11	48510885	48510885	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:48510885C>T	ENST00000446524.1	+	1	617	c.541C>T	c.(541-543)Ccc>Tcc	p.P181S		NM_001005512.2	NP_001005512.2	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A, member 47	181					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P181A(1)		NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(18)|ovary(1)|skin(1)|urinary_tract(2)	29						TGACATGTATCCCTTATTGAA	0.443000													43	87					0	0	1	0	0
DHX34	9704	broad.mit.edu	37	19	47879316	47879316	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:47879316C>T	ENST00000328771.4	+	11	2792	c.2443C>T	c.(2443-2445)Ccc>Tcc	p.P815S		NM_014681.5	NP_055496.2	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	815						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(5)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		GCTGGCCGTCCCCGACGCCTT	0.652000													37	36					0	0	1	0	0
FAM177B	400823	broad.mit.edu	37	1	222919979	222919979	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:222919979G>A	ENST00000445590.2	+	3	358	c.92G>A	c.(91-93)gGa>gAa	p.G31E	FAM177B_ENST00000360827.2_Missense_Mutation_p.G31E	NM_207468.2	NP_997351.2	A6PVY3	F177B_HUMAN	family with sequence similarity 177, member B	31										breast(1)|central_nervous_system(1)|endometrium(1)|lung(2)|ovary(1)|prostate(1)|stomach(1)	8						TTTGTTGACGGAGACATCATG	0.413000													22	37					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10943004	10943004	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr21:10943004G>A	ENST00000298232.7	-	11	896	c.529C>T	c.(529-531)Cga>Tga	p.R177*	TPTE_ENST00000342420.5_Nonsense_Mutation_p.R157*|TPTE_ENST00000361285.4_Nonsense_Mutation_p.R195*|TPTE_ENST00000415664.2_5'UTR	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	195					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R177*(2)		NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CGTAGAAGTCGAAGTAAATGT	0.308000													6	25					0	0	1	0	0
MAP3K15	389840	broad.mit.edu	37	X	19482432	19482432	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chrX:19482432G>A	ENST00000338883.4	-	4	617	c.618C>T	c.(616-618)tcC>tcT	p.S206S	MAP3K15_ENST00000518578.1_5'UTR|MAP3K15_ENST00000469203.2_Silent_p.S38S	NM_001001671.3	NP_001001671.3	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase 15	206							ATP binding|MAP kinase kinase kinase activity|metal ion binding			NS(2)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(13)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	Hepatocellular(33;0.183)					GCATGTACTCGGAGGCTCGTC	0.512000													25	7					0	0	1	0	0
NEURL1	9148	broad.mit.edu	37	10	105330842	105330842	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr10:105330842T>G	ENST00000369780.4	+	2	708	c.299T>G	c.(298-300)gTc>gGc	p.V100G	NEURL_ENST00000369777.2_Missense_Mutation_p.V83G	NM_004210.4	NP_004201.3	O76050	NEU1A_HUMAN		100	NHR 1.				nervous system development	perinuclear region of cytoplasm	zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	17				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		AACCGCCCGGTCCTCATCTAC	0.662000													29	47					0	0	1	0	0
RGPD8	727851	broad.mit.edu	37	2	113127775	113127775	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr2:113127775G>C	ENST00000302558.3	-	23	5469	c.5278C>G	c.(5278-5280)Cct>Gct	p.P1760A	RGPD8_ENST00000409750.1_Missense_Mutation_p.P1620A	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8									p.P1760A(12)		endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						GAACGGGAAGGATTTTCTTCC	0.308000													3	59					0	0	1	0	0
INSR	3643	broad.mit.edu	37	19	7267492	7267492	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:7267492G>A	ENST00000341500.5	-	2	555	c.516C>T	c.(514-516)atC>atT	p.I172I	INSR_ENST00000302850.5_Silent_p.I172I	NM_001079817.1	NP_001073285.1	P06213	INSR_HUMAN	insulin receptor	172					activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			breast(1)|central_nervous_system(4)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(4)|prostate(4)|skin(3)|stomach(2)|urinary_tract(2)	66					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGTTCAACACGATGTAATTAT	0.542000													22	48					0	0	1	0	0
CDK13	8621	broad.mit.edu	37	7	40133782	40133782	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:40133782G>A	ENST00000181839.4	+	14	4347	c.3742G>A	c.(3742-3744)Gaa>Aaa	p.E1248K	CDK13_ENST00000340829.5_Missense_Mutation_p.E1188K	NM_003718.4|NM_031267.3	NP_003709.3|NP_112557.2	Q14004	CDK13_HUMAN	cyclin-dependent kinase 13	1248					alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(1)|pancreas(2)|prostate(2)|skin(5)|stomach(2)|urinary_tract(1)	49						GCTAACGCCAGAACCAGACCG	0.483000													53	63					0	0	1	0	0
MMP9	4318	broad.mit.edu	37	20	44644942	44644942	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr20:44644942G>A	ENST00000372330.3	+	13	2078	c.2059G>A	c.(2059-2061)Gag>Aag	p.E687K	RP11-465L10.10_ENST00000535913.1_RNA	NM_004994.2	NP_004985.2	P14780	MMP9_HUMAN	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	687	Hemopexin-like 4.				collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(4)|large_intestine(14)|liver(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	46		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	TTCCCGGAGTGAGTTGAACCA	0.552000													44	53					0	0	1	0	0
AMICA1	120425	broad.mit.edu	37	11	118074365	118074365	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:118074365G>A	ENST00000292067.7	-	5	961	c.520C>T	c.(520-522)Cgt>Tgt	p.R174C	AMICA1_ENST00000356289.5_Missense_Mutation_p.R184C|AMICA1_ENST00000526620.1_Missense_Mutation_p.R145C|AMICA1_ENST00000533261.1_Missense_Mutation_p.R173C	NM_153206.2	NP_694938.2	Q86YT9	JAML1_HUMAN	adhesion molecule, interacts with CXADR antigen 1	184	Ig-like V-type 2.				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	cell junction|integral to membrane		p.R174G(1)|p.R174C(1)		central_nervous_system(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|stomach(2)	20	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		TGGTAGTAACGAAATACAATC	0.502000													31	45					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38121291	38121291	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr22:38121291C>T	ENST00000406386.3	+	7	2983	c.2728C>T	c.(2728-2730)Ccc>Tcc	p.P910S	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	910					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					GGCCTCGTTTCCCCTCCGGCC	0.577000													91	138					0	0	1	0	0
TMEM156	80008	broad.mit.edu	37	4	39000290	39000290	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr4:39000290C>T	ENST00000381938.3	-	2	435	c.328G>A	c.(328-330)Gat>Aat	p.D110N	TMEM156_ENST00000372489.2_5'UTR	NM_024943.1	NP_079219.1	Q8N614	TM156_HUMAN	transmembrane protein 156	110						integral to membrane				endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)|stomach(1)	10						GAAATAAAATCCATGTTTCCT	0.343000													10	11					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75899096	75899096	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr6:75899096C>T	ENST00000322507.8	-	7	969	c.658_splice	c.e7-1	p.G220_splice	COL12A1_ENST00000345356.6_Intron|COL12A1_ENST00000483888.2_Splice_Site_p.G220_splice|COL12A1_ENST00000416123.2_Splice_Site_p.G220_splice	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	220	VWFA 1.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						CAATGGCATCCCCTAAAGGGA	0.328000													14	9					0	0	1	0	0
ATP6V0C	527	broad.mit.edu	37	16	2569325	2569325	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:2569325T>C	ENST00000564543.1	+	2	1189	c.1072T>C	c.(1072-1074)Tgg>Cgg	p.W358R	ATP6C_ENST00000569317.1_Intron|ATP6V0C_ENST00000564973.1_Silent_p.A19A|ATP6V0C_ENST00000568562.1_Missense_Mutation_p.W45R|ATP6V0C_ENST00000565223.1_Silent_p.A19A|ATP6V0C_ENST00000330398.4_Silent_p.A62A																							TGGTCATGGCTGGCATCATCG	0.602000													30	43					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61958257	61958257	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr10:61958257C>T	ENST00000280772.1	-	14	1721	c.1530G>A	c.(1528-1530)ggG>ggA	p.G510G	ANK3_ENST00000503366.1_Silent_p.G493G|ANK3_ENST00000373827.2_Silent_p.G504G	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	510					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TGTCTGCTTTCCCCAGTCGGG	0.507000													42	64					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18435240	18435240	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:18435240G>A	ENST00000433979.1	+	2	341	c.225G>A	c.(223-225)ggG>ggA	p.G75G	RERGL_ENST00000541632.1_Intron|PIK3C2G_ENST00000538779.1_Silent_p.G75G|PIK3C2G_ENST00000266497.5_Silent_p.G75G|PIK3C2G_ENST00000535651.1_Silent_p.G75G	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	75					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				ACTCAACAGGGCATTCATTAA	0.408000													38	69					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	62023607	62023607	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr10:62023607C>T	ENST00000280772.1	-	6	876	c.685G>A	c.(685-687)Gat>Aat	p.D229N	ANK3_ENST00000503366.1_Missense_Mutation_p.D212N|ANK3_ENST00000373827.2_Missense_Mutation_p.D223N	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	229					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GATTCCACATCTGCATTGTTG	0.552000													14	28					0	0	1	0	0
TMPRSS11D	9407	broad.mit.edu	37	4	68691544	68691544	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr4:68691544T>A	ENST00000283916.6	-	9	1099	c.1001A>T	c.(1000-1002)aAt>aTt	p.N334I	TMPRSS11D_ENST00000545541.1_Missense_Mutation_p.N217I|RP11-453E17.1_ENST00000500538.2_RNA	NM_004262.2	NP_004253.1	O60235	TM11D_HUMAN	transmembrane protease, serine 11D	334	Peptidase S1.				proteolysis|respiratory gaseous exchange	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						ACATACATCATTACTTATTAT	0.418000													35	60					0	0	1	0	0
TST	7263	broad.mit.edu	37	22	37414218	37414218	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr22:37414218C>T	ENST00000403892.3	-	1	1290	c.556G>A	c.(556-558)Ggg>Agg	p.G186R	TST_ENST00000249042.3_Missense_Mutation_p.G186R	NM_001270483.1	NP_001257412.1	Q16762	THTR_HUMAN	thiosulfate sulfurtransferase (rhodanese)	186	Rhodanese 2.				cyanate catabolic process|rRNA transport	mitochondrial matrix|plasma membrane	5S rRNA binding|thiosulfate sulfurtransferase activity			kidney(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)|urinary_tract(1)	7						AGGAACCGCCCTTGAGACCTT	0.587000													8	15					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73961966	73961966	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chrX:73961966A>C	ENST00000373468.1	-	3	3077	c.2426T>G	c.(2425-2427)gTt>gGt	p.V809G	KIAA2022_ENST00000055682.5_Missense_Mutation_p.V809G			Q5QGS0	K2022_HUMAN	KIAA2022	809					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						TCCCGGGATAACAGGTATATT	0.408000													57	27					0	0	1	0	0
CLEC4C	170482	broad.mit.edu	37	12	7882201	7882201	+	Silent	SNP	G	G	A	rs142052046	by1000genomes	TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:7882201G>A	ENST00000542353.1	-	7	1123	c.633C>T	c.(631-633)atC>atT	p.I211I	CLEC4C_ENST00000540085.1_Silent_p.I180I|CLEC4C_ENST00000354629.5_Silent_p.I180I|CLEC4C_ENST00000360345.3_Silent_p.I211I	NM_130441.2	NP_569708.1	Q8WTT0	CLC4C_HUMAN	C-type lectin domain family 4, member C	211					innate immune response	integral to membrane	sugar binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				Kidney(36;0.0915)		TTTATATGTAGATCTTCTTCA	0.358000													26	32					0	0	1	0	0
SLC6A18	348932	broad.mit.edu	37	5	1232389	1232389	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:1232389C>T	ENST00000324642.3	+	2	339	c.216C>T	c.(214-216)ttC>ttT	p.F72F	SLC6A18_ENST00000296821.4_Silent_p.F72F	NM_182632.2	NP_872438.2	Q96N87	S6A18_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 18	72					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(4)|upper_aerodigestive_tract(1)	34	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TCCCCATTTTCCACGTCGAGC	0.677000													12	17					0	0	1	0	0
DRD5	1816	broad.mit.edu	37	4	9784947	9784947	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr4:9784947G>A	ENST00000304374.2	+	1	1690	c.1294G>A	c.(1294-1296)Ggt>Agt	p.G432S		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	432					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CGAGGAGGAGGGTCCTTTCGA	0.567000													28	57					0	0	1	0	0
ZSCAN31	64288	broad.mit.edu	37	6	28294113	28294113	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr6:28294113A>G	ENST00000414429.1	-	8	1954	c.1051T>C	c.(1051-1053)Tat>Cat	p.Y351H	ZSCAN31_ENST00000439158.1_Missense_Mutation_p.Y351H|ZSCAN31_ENST00000344279.6_Missense_Mutation_p.Y351H|ZSCAN31_ENST00000446474.1_Missense_Mutation_p.Y192H|ZSCAN31_ENST00000396838.2_Missense_Mutation_p.Y351H|ZSCAN31_ENST00000481934.1_5'UTR					zinc finger and SCAN domain containing 31																		CGACACTGATAGCGCTTCTCT	0.502000													56	136					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89381922	89381922	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr15:89381922C>T	ENST00000439576.2	+	3	473	c.99C>T	c.(97-99)atC>atT	p.I33I	ACAN_ENST00000561243.1_Silent_p.I33I|ACAN_ENST00000559004.1_Silent_p.I33I|ACAN_ENST00000558207.1_Silent_p.I33I|ACAN_ENST00000352105.7_Silent_p.I33I	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	33					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GTGTCAGCATCCCCCAACCGT	0.617000													60	98					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122003562	122003562	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:122003562G>A	ENST00000498619.1	+	7	3229	c.2791G>A	c.(2791-2793)Gaa>Aaa	p.E931K	CASR_ENST00000296154.5_Missense_Mutation_p.E921K|CASR_ENST00000490131.1_Missense_Mutation_p.E921K	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	921					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GAGCAACAGCGAAGACCCATT	0.662000													21	42					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48177960	48177960	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:48177960C>T	ENST00000311303.3	-	2	481	c.136G>A	c.(136-138)Gtg>Atg	p.V46M	ABCC12_ENST00000448542.1_Missense_Mutation_p.V46M|ABCC12_ENST00000416054.1_Missense_Mutation_p.V46M	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	46						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				GCATCATCCACCGGGTTGGGT	0.572000													19	35					0	0	1	0	0
ILDR1	286676	broad.mit.edu	37	3	121725865	121725865	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:121725865C>T	ENST00000273691.3	-	2	307	c.202G>A	c.(202-204)Gac>Aac	p.D68N	ILDR1_ENST00000462014.1_Missense_Mutation_p.D80N|ILDR1_ENST00000460554.1_5'UTR|ILDR1_ENST00000393631.1_Missense_Mutation_p.D68N|ILDR1_ENST00000344209.5_Missense_Mutation_p.D68N	NM_175924.3	NP_787120.1	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor 1	68	Ig-like V-type.					cytosol|integral to membrane|plasma membrane	receptor activity	p.D68N(1)		central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(114;0.156)		AAGATAGGGTCCTTGCAGAAG	0.542000													12	23					0	0	1	0	0
SEMA3C	10512	broad.mit.edu	37	7	80456775	80456775	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:80456775A>C	ENST00000265361.3	-	4	854	c.293T>G	c.(292-294)gTt>gGt	p.V98G	SEMA3C_ENST00000536800.1_Intron|SEMA3C_ENST00000544525.1_Missense_Mutation_p.V116G|SEMA3C_ENST00000419255.2_Missense_Mutation_p.V98G	NM_006379.3	NP_006370.1	Q99985	SEM3C_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	98	Sema.				immune response|response to drug	membrane	receptor activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						GCATTCTTCAACTTTGATTGT	0.343000													8	17					0	0	1	0	0
TRIM71	131405	broad.mit.edu	37	3	32932856	32932856	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:32932856G>A	ENST00000383763.4	+	4	2223	c.2160G>A	c.(2158-2160)agG>agA	p.R720R		NM_001039111.1	NP_001034200.1	Q2Q1W2	LIN41_HUMAN	tripartite motif containing 71, E3 ubiquitin protein ligase	720					multicellular organismal development	cytoplasm	zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CAGACACGAGGAACCACCGGA	0.542000													15	18					0	0	1	0	0
GPX5	2880	broad.mit.edu	37	6	28500097	28500097	+	Splice_Site	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr6:28500097G>A	ENST00000412168.2	+	4	448		c.e4-1		GPX5_ENST00000442674.2_Splice_Site|GPX5_ENST00000469384.1_Splice_Site	NM_001509.2	NP_001500.1	O75715	GPX5_HUMAN	glutathione peroxidase 5 (epididymal androgen-related protein)						lipid metabolic process|response to oxidative stress	extracellular region	glutathione peroxidase activity			endometrium(2)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16					Glutathione(DB00143)	GCTTGTTGCAGGTATGTCCGT	0.433000													29	55					0	0	1	0	0
TEP1	7011	broad.mit.edu	37	14	20876165	20876165	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr14:20876165T>A	ENST00000262715.5	-	2	474	c.434A>T	c.(433-435)aAc>aTc	p.N145I	TEP1_ENST00000556935.1_Missense_Mutation_p.N145I	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	145					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		ATTGCTGTTGTTCACACGGTA	0.507000													62	106					0	0	1	0	0
POU4F1	5457	broad.mit.edu	37	13	79176588	79176588	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr13:79176588A>T	ENST00000377208.5	-	2	433	c.222T>A	c.(220-222)caT>caA	p.H74Q	RNF219-AS1_ENST00000606376.1_RNA|RNF219-AS1_ENST00000560584.2_RNA|RNF219-AS1_ENST00000606124.1_RNA|RNF219-AS1_ENST00000560209.2_RNA|RNF219-AS1_ENST00000607860.1_RNA|RNF219-AS1_ENST00000606429.1_RNA|RNF219-AS1_ENST00000444769.3_RNA|RNF219-AS1_ENST00000607205.1_RNA|RNF219-AS1_ENST00000430549.2_RNA|RNF219-AS1_ENST00000607220.1_RNA	NM_006237.3	NP_006228.3	Q01851	PO4F1_HUMAN	POU class 4 homeobox 1	74					axonogenesis|regulation of transcription from RNA polymerase II promoter|synapse assembly	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(5)|ovary(1)	16		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.129)		GCTTGAAAGGATGGCTCTTGC	0.677000													10	2					0	0	1	0	0
CDH7	1005	broad.mit.edu	37	18	63489462	63489462	+	Silent	SNP	T	T	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr18:63489462T>C	ENST00000536984.2	+	5	1465	c.771T>C	c.(769-771)gaT>gaC	p.D257D	CDH7_ENST00000323011.3_Silent_p.D257D|CDH7_ENST00000397968.2_Silent_p.D257D			Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	257	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				ATGTCAACGATAATCCACCTC	0.383000													15	31					0	0	1	0	0
LEPR	3953	broad.mit.edu	37	1	66091824	66091824	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:66091824G>A	ENST00000344610.8	+	20	2964	c.2692G>A	c.(2692-2694)Gaa>Aaa	p.E898K	LEPR_ENST00000349533.6_Intron|LEPR_ENST00000371060.3_Intron|LEPR_ENST00000406510.3_Intron|LEPR_ENST00000371058.1_Missense_Mutation_p.E898K|LEPR_ENST00000371059.3_Intron			P48357	LEPR_HUMAN	leptin receptor	0	Required for JAK2 activation (By similarity).				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TGGCACAAAGGAACTACTGGG	0.493000													10	15					0	0	1	0	0
ZBTB43	23099	broad.mit.edu	37	9	129596081	129596081	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr9:129596081T>A	ENST00000373464.4	+	3	1557	c.1293T>A	c.(1291-1293)aaT>aaA	p.N431K	ZBTB43_ENST00000373457.1_Missense_Mutation_p.N431K|ZBTB43_ENST00000449886.1_Missense_Mutation_p.N431K	NM_014007.3	NP_054726.1	O43298	ZBT43_HUMAN	zinc finger and BTB domain containing 43	431					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(3)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14						ATGAGTGTAATATCTGTGCAA	0.473000													64	61					0	0	1	0	0
NAT8L	339983	broad.mit.edu	37	4	2062819	2062819	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr4:2062819C>T	ENST00000423729.2	+	2	471	c.471C>T	c.(469-471)atC>atT	p.I157I	NAT8L_ENST00000331662.3_5'UTR	NM_178557.3	NP_848652.2	Q8N9F0	NAT8L_HUMAN	N-acetyltransferase 8-like (GCN5-related, putative)	157	N-acetyltransferase.					integral to membrane|microsome|mitochondrial membrane|rough endoplasmic reticulum membrane	aspartate N-acetyltransferase activity			haematopoietic_and_lymphoid_tissue(1)|lung(1)	2			OV - Ovarian serous cystadenocarcinoma(23;0.0315)			GCAAGGTGATCCGCGCCTACC	0.697000													12	27					0	0	1	0	0
TENC1	23371	broad.mit.edu	37	12	53447585	53447585	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:53447585A>G	ENST00000314250.6	+	5	579	c.289A>G	c.(289-291)Ata>Gta	p.I97V	RP11-983P16.4_ENST00000550601.1_RNA|RP11-983P16.4_ENST00000551890.1_RNA|TENC1_ENST00000549700.1_Missense_Mutation_p.I97V|TENC1_ENST00000451358.1_Missense_Mutation_p.I97V|TENC1_ENST00000379902.3_5'UTR|TENC1_ENST00000314276.3_Missense_Mutation_p.I107V|TENC1_ENST00000552570.1_Missense_Mutation_p.I97V|TENC1_ENST00000546602.1_Missense_Mutation_p.I97V|RP11-983P16.4_ENST00000546793.1_RNA	NM_170754.2	NP_736610.2	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase (tensin 2)	97					intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(19)|ovary(1)|pancreas(1)|stomach(3)	34						AGTCAGGCGCATAGAGCACCT	0.567000											OREG0021855	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	58					0	0	1	0	0
HMGCLL1	54511	broad.mit.edu	37	6	55406860	55406860	+	Nonsense_Mutation	SNP	T	T	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr6:55406860T>A	ENST00000398661.2	-	3	408	c.277A>T	c.(277-279)Aag>Tag	p.K93*	HMGCLL1_ENST00000274901.4_Nonsense_Mutation_p.K63*|HMGCLL1_ENST00000370850.2_Nonsense_Mutation_p.K63*|HMGCLL1_ENST00000308161.4_Nonsense_Mutation_p.K63*|HMGCLL1_ENST00000428842.1_Nonsense_Mutation_p.K63*|HMGCLL1_ENST00000508459.1_Nonsense_Mutation_p.K63*	NM_019036.2	NP_061909.2	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1	93							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	31	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			AAAACTACCTTTTCATTCTGC	0.308000													18	17					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114290802	114290802	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr4:114290802C>T	ENST00000357077.4	+	43	11504	c.11451C>T	c.(11449-11451)tcC>tcT	p.S3817S	ANK2_ENST00000394537.3_Silent_p.S1732S|ANK2_ENST00000506722.1_Silent_p.S1723S|ANK2_ENST00000510275.2_Silent_p.S384S|ANK2_ENST00000264366.6_Silent_p.S3784S|ANK2_ENST00000509550.1_Silent_p.S908S	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	3784					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CCCCAACATCCAGCGAGCGGG	0.567000													35	46					0	0	1	0	0
IFNE	338376	broad.mit.edu	37	9	21481263	21481263	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr9:21481263A>C	ENST00000448696.3	-	1	1049	c.431T>G	c.(430-432)gTt>gGt	p.V144G	MIR31HG_ENST00000304425.3_RNA	NM_176891.4	NP_795372.1	Q86WN2	IFNE_HUMAN	interferon, epsilon	144					defense response|response to virus	extracellular space	cytokine activity|cytokine receptor binding			large_intestine(2)|lung(1)|skin(1)	4						GTACATTTTAACTTGTAATCT	0.438000													79	47					0	0	1	0	0
CATSPERB	79820	broad.mit.edu	37	14	92091262	92091262	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr14:92091262G>A	ENST00000256343.3	-	18	1988	c.1832C>T	c.(1831-1833)cCc>cTc	p.P611L		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	611					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				TAATCCAAAGGGCTCTTTCAT	0.353000													12	23					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150174830	150174830	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:150174830G>A	ENST00000307271.3	+	5	2534	c.1960G>A	c.(1960-1962)Gaa>Aaa	p.E654K		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	654						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		GTCCCAAGCCGAAAAACTCCT	0.463000													35	51					0	0	1	0	0
ANKRD24	170961	broad.mit.edu	37	19	4222685	4222685	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:4222685G>A	ENST00000600132.1	+	20	3466	c.3190G>A	c.(3190-3192)Gaa>Aaa	p.E1064K	ANKRD24_ENST00000262970.5_Missense_Mutation_p.E1154K|ANKRD24_ENST00000318934.4_Missense_Mutation_p.E1064K	NM_133475.1	NP_597732.1	Q8TF21	ANR24_HUMAN	ankyrin repeat domain 24	1064										endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	21				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		ACTCTCCAAAGAAGTCTTCAA	0.597000													7	14					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13923485	13923485	+	Silent	SNP	G	G	A	rs145920072	byFrequency	TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:13923485G>A	ENST00000265104.4	-	4	446	c.342C>T	c.(340-342)ttC>ttT	p.F114F		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	114	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CCTCGGTCACGAACACCTTAG	0.433000									Kartagener syndrome				46	90					0	0	1	0	0
PRKACG	5568	broad.mit.edu	37	9	71628154	71628154	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr9:71628154G>A	ENST00000377276.2	-	1	885	c.855C>T	c.(853-855)ctC>ctT	p.L285L		NM_002732.3	NP_002723.2	P22612	KAPCG_HUMAN	protein kinase, cAMP-dependent, catalytic, gamma	285	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|gluconeogenesis|intracellular protein kinase cascade|male gonad development|nerve growth factor receptor signaling pathway|regulation of insulin secretion|spermatogenesis|transmembrane transport|triglyceride catabolic process|water transport	cytosol|nucleoplasm	ATP binding|cAMP-dependent protein kinase activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						CCCCGTTCCTGAGGTTTCCGA	0.572000													41	30					0	0	1	0	0
TGM6	343641	broad.mit.edu	37	20	2411598	2411598	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr20:2411598C>T	ENST00000202625.2	+	12	1953	c.1892C>T	c.(1891-1893)cCc>cTc	p.P631L	TGM6_ENST00000381423.1_Intron	NM_198994.2	NP_945345.2	O95932	TGM3L_HUMAN	transglutaminase 6	631					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	GTAGTCAACCCCCTCATAGAG	0.612000													47	75					0	0	1	0	0
ELOVL1	64834	broad.mit.edu	37	1	43830935	43830935	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:43830935C>T	ENST00000372458.3	-	3	276	c.159G>A	c.(157-159)cgG>cgA	p.R53R	ELOVL1_ENST00000470769.1_5'UTR|ELOVL1_ENST00000413844.2_Silent_p.R53R	NM_001256399.1|NM_001256402.1|NM_022821.3	NP_001243328.1|NP_001243331.1|NP_073732.1	Q9BW60	ELOV1_HUMAN	ELOVL fatty acid elongase 1	53					fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|sphingolipid biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	fatty acid elongase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|prostate(1)	4	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GGAAGGGCTTCCGATTAGCCA	0.562000													12	18					0	0	1	0	0
FNBP4	23360	broad.mit.edu	37	11	47744695	47744695	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr11:47744695G>A	ENST00000263773.5	-	15	2650	c.2638C>T	c.(2638-2640)Cca>Tca	p.P880S		NM_015308.2	NP_056123.2	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	880										NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	44						ACTCCAATTGGGACAGAACAT	0.537000													25	35					0	0	1	0	0
VCL	7414	broad.mit.edu	37	10	75854133	75854133	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr10:75854133C>T	ENST00000211998.4	+	11	1551	c.1457C>T	c.(1456-1458)cCg>cTg	p.P486L	VCL_ENST00000478896.2_Intron|VCL_ENST00000417648.2_Intron|VCL_ENST00000372755.3_Missense_Mutation_p.P486L	NM_014000.2	NP_054706.1	P18206	VINC_HUMAN	vinculin	486	3 X 112 AA tandem repeats.|N-terminal globular head.				adherens junction assembly|apical junction assembly|cell-matrix adhesion|cellular component movement|epithelial cell-cell adhesion|lamellipodium assembly|morphogenesis of an epithelium|muscle contraction|negative regulation of cell migration|platelet activation|platelet degranulation|protein localization at cell surface	costamere|cytosol|extracellular region|focal adhesion	actin binding|alpha-catenin binding|beta-catenin binding|beta-dystroglycan binding|cadherin binding|structural molecule activity		VCL/ALK(4)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	20	Prostate(51;0.0112)					AACAGCAGACCGGCCAAAGCA	0.577000													16	23					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	40075862	40075862	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr22:40075862G>A	ENST00000336649.4	+	36	5548	c.5548G>A	c.(5548-5550)Gac>Aac	p.D1850N	CACNA1I_ENST00000407673.1_Missense_Mutation_p.D1809N|CACNA1I_ENST00000404898.1_Missense_Mutation_p.D1809N|CACNA1I_ENST00000402142.3_Missense_Mutation_p.D1844N|CACNA1I_ENST00000401624.1_Missense_Mutation_p.D1844N|CACNA1I_ENST00000400164.3_Missense_Mutation_p.D1809N			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	1844					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GTGTCACCACGACAAGCAAGA	0.642000													7	13					0	0	1	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70714181	70714181	+	RNA	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr14:70714181C>T	ENST00000530196.1	-	0	337					NR_003951.1																						GTCCCCAAACCGCAGACTATA	0.522000													5	99					0	0	1	0	0
SLCO1A2	6579	broad.mit.edu	37	12	21422497	21422497	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:21422497C>T	ENST00000307378.6	-	16	2718	c.1998G>A	c.(1996-1998)ttG>ttA	p.L666L	SLCO1A2_ENST00000537524.1_Silent_p.L534L|SLCO1A2_ENST00000452078.1_Silent_p.L666L|SLCO1A2_ENST00000458504.1_Silent_p.L534L	NM_134431.3	NP_602307.1	P46721	SO1A2_HUMAN	solute carrier organic anion transporter family, member 1A2	666					bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(6)|upper_aerodigestive_tract(1)	48						ATTTAGTTTTCAATTCATCAT	0.299000													22	49					0	0	1	0	0
PLEKHA6	22874	broad.mit.edu	37	1	204199581	204199581	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:204199581C>T	ENST00000272203.3	-	18	2859	c.2543G>A	c.(2542-2544)aGc>aAc	p.S848N	PLEKHA6_ENST00000414478.1_Missense_Mutation_p.S868N	NM_014935.4	NP_055750.2	Q9Y2H5	PKHA6_HUMAN	pleckstrin homology domain containing, family A member 6	848										breast(2)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			GGGGGCCGGGCTGGCCGGGAG	0.657000													6	7					0	0	1	0	0
TAF4B	6875	broad.mit.edu	37	18	23866290	23866290	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr18:23866290G>A	ENST00000269142.5	+	7	2415	c.1417G>A	c.(1417-1419)Gaa>Aaa	p.E473K	TAF4B_ENST00000400466.2_Missense_Mutation_p.E473K|TAF4B_ENST00000578121.1_Missense_Mutation_p.E473K	NM_005640.1	NP_005631.1	Q92750	TAF4B_HUMAN	TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa	473					transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleolus|transcription factor TFIID complex	DNA binding|NF-kappaB binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(13)|prostate(1)|skin(1)	29	all_cancers(21;0.00151)|Lung NSC(5;0.000401)|all_lung(6;0.00115)|Ovarian(20;0.124)		Epithelial(2;9.57e-07)|all cancers(3;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(3;1.96e-05)|LUSC - Lung squamous cell carcinoma(2;0.00594)|Lung(2;0.0267)			AACTTTTGGAGAAACTTCAGG	0.468000													25	42					0	0	1	0	0
MARC1	64757	broad.mit.edu	37	1	220986731	220986731	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:220986731G>A	ENST00000366910.5	+	7	1171	c.985G>A	c.(985-987)Gga>Aga	p.G329R	MARC1_ENST00000496110.1_3'UTR	NM_022746.3	NP_073583.3	Q5VT66	MOSC1_HUMAN	mitochondrial amidoxime reducing component 1	329	MOSC.						molybdenum ion binding|oxidoreductase activity|pyridoxal phosphate binding										CATCAAAGTGGGAGACCCTGT	0.438000													42	76					0	0	1	0	0
ZNF284	342909	broad.mit.edu	37	19	44591032	44591032	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:44591032C>T	ENST00000421176.3	+	5	1617	c.1401C>T	c.(1399-1401)gcC>gcT	p.A467A	ZNF223_ENST00000591793.1_3'UTR	NM_001037813.2	NP_001032902.1	Q2VY69	ZN284_HUMAN	zinc finger protein 284	467					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|kidney(2)|large_intestine(6)|lung(4)|upper_aerodigestive_tract(1)	15		Prostate(69;0.0435)				TCAGGTGGGCCTCAGGTATTT	0.423000													25	37					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19744891	19744891	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:19744891G>A	ENST00000203556.4	-	19	2330	c.2193C>T	c.(2191-2193)atC>atT	p.I731I	GMIP_ENST00000445806.2_Silent_p.I702I|GMIP_ENST00000587238.1_Silent_p.I705I	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	731	Rho-GAP.				negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						AGGTGACAGGGATGGCGCTGG	0.612000													35	77					0	0	1	0	0
TRBV5-1	28614	broad.mit.edu	37	7	142020932	142020932	+	RNA	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:142020932C>T	ENST00000390381.3	+	0	348																											TGCTTTGTCTCCTGGGAGCAG	0.607000													7	9					0	0	1	0	0
C1orf159	54991	broad.mit.edu	37	1	1018302	1018302	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:1018302G>A	ENST00000448924.1	-	11	1545	c.1114C>T	c.(1114-1116)Ccg>Tcg	p.P372S	C1orf159_ENST00000379319.1_Missense_Mutation_p.P190S|C1orf159_ENST00000421241.2_Missense_Mutation_p.P190S|C1orf159_ENST00000294576.5_Missense_Mutation_p.P336S|C1orf159_ENST00000379339.1_Missense_Mutation_p.P372S|C1orf159_ENST00000379320.1_Missense_Mutation_p.P336S			Q96HA4	CA159_HUMAN	chromosome 1 open reading frame 159	372						integral to membrane						all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.96e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.77e-22)|Colorectal(212;6.51e-05)|COAD - Colon adenocarcinoma(227;0.000214)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|Kidney(185;0.00254)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		GCCTCCCCCGGGAAGGCAGCG	0.697000													5	9					0	0	1	0	0
ARFGAP3	26286	broad.mit.edu	37	22	43243591	43243591	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr22:43243591G>A	ENST00000263245.5	-	2	336	c.117C>T	c.(115-117)acC>acT	p.T39T	ARFGAP3_ENST00000437119.2_Silent_p.T39T|ARFGAP3_ENST00000429508.2_Silent_p.T39T|PACSIN2_ENST00000496919.1_5'UTR	NM_001142293.1|NM_014570.4	NP_001135765.1|NP_055385.3	Q9NP61	ARFG3_HUMAN	ADP-ribosylation factor GTPase activating protein 3	39	Arf-GAP.				intracellular protein transport|protein secretion|regulation of ARF GTPase activity|vesicle-mediated transport	cytosol|Golgi membrane	ARF GTPase activator activity|protein transporter activity|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)	11						ACACTCCATAGGTTATGCTTG	0.393000													14	26					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25490691	25490691	+	RNA	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr15:25490691G>A	ENST00000453082.2	+	0	2719				SNORD115-41_ENST00000363608.1_RNA	NR_003343.1																						TGCTCAATAGGATTACGCTGA	0.502000													133	264					0	0	1	0	0
FLRT2	23768	broad.mit.edu	37	14	86088099	86088099	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr14:86088099C>T	ENST00000330753.4	+	2	1008	c.241C>T	c.(241-243)Cct>Tct	p.P81S	FLRT2_ENST00000554746.1_Missense_Mutation_p.P81S	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	81					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TGCTGGATTTCCTGCAGAACT	0.488000													49	80					0	0	1	0	0
HNRNPL	3191	broad.mit.edu	37	19	39336517	39336517	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:39336517C>T	ENST00000221419.5	-	3	966	c.600G>A	c.(598-600)ctG>ctA	p.L200L	HNRNPL_ENST00000600873.1_Silent_p.L67L	NM_001533.2	NP_001524.2	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	200	RRM 2.				nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	30	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			AAATGGGGTTCAGGATGGTAA	0.537000													42	63					0	0	1	0	0
TMEM37	140738	broad.mit.edu	37	2	120194857	120194857	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr2:120194857C>T	ENST00000306406.4	+	2	449	c.414C>T	c.(412-414)tcC>tcT	p.S138S	TMEM37_ENST00000409826.1_Silent_p.S150S|TMEM37_ENST00000465296.1_3'UTR	NM_183240.2	NP_899063.2	Q8WXS4	CCGL_HUMAN	transmembrane protein 37	138						integral to membrane	calcium channel activity|voltage-gated ion channel activity			breast(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	11						TCGTCCTCTCCTCCGGCGGGC	0.557000													211	56					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	92982996	92982996	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr8:92982996C>T	ENST00000523629.1	-	11	1883	c.1429G>A	c.(1429-1431)Gac>Aac	p.D477N	RUNX1T1_ENST00000422361.2_Missense_Mutation_p.D440N|RUNX1T1_ENST00000436581.2_Missense_Mutation_p.D488N|RUNX1T1_ENST00000396218.1_Missense_Mutation_p.D450N|RUNX1T1_ENST00000360348.2_Missense_Mutation_p.D440N|RUNX1T1_ENST00000265814.3_Missense_Mutation_p.D477N|RUNX1T1_ENST00000520724.1_Missense_Mutation_p.D440N|RUNX1T1_ENST00000518844.1_Missense_Mutation_p.D450N	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	477					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			GTGATCATGTCGTGGGCTTTC	0.627000													20	36					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7585391	7585391	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr6:7585391C>T	ENST00000379802.3	+	24	8237	c.7896C>T	c.(7894-7896)tcC>tcT	p.S2632S	DSP_ENST00000418664.2_Silent_p.S2033S	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2632	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AGAAAATCTCCATTACAGAAG	0.517000													46	77					0	0	1	0	0
PIP4K2B	8396	broad.mit.edu	37	17	36925970	36925970	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:36925970C>T	ENST00000269554.3	-	10	1705	c.1225G>A	c.(1225-1227)Gag>Aag	p.E409K		NM_003559.4	NP_003550.1	P78356	PI42B_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type II, beta	409	PIPK.				cell surface receptor linked signaling pathway	endoplasmic reticulum membrane|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|receptor signaling protein activity			endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(8)|ovary(1)	19						GACATAAACTCGTTGAAGCGT	0.527000													73	130					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7618599	7618599	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr10:7618599C>T	ENST00000256861.6	-	10	1873	c.1795G>A	c.(1795-1797)Gag>Aag	p.E599K	ITIH5_ENST00000298441.6_Missense_Mutation_p.E385K|ITIH5_ENST00000397145.2_Missense_Mutation_p.E599K|ITIH5_ENST00000446830.2_Missense_Mutation_p.E381K|ITIH5_ENST00000434980.1_5'UTR|ITIH5_ENST00000397146.2_Missense_Mutation_p.E599K	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	599					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						CGCAGCCGCTCCTTCTCCGGT	0.637000													27	51					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	96706361	96706361	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:96706361G>A	ENST00000389672.5	+	3	676	c.638G>A	c.(637-639)gGg>gAg	p.G213E	EPHA6_ENST00000542517.1_Missense_Mutation_p.G119E|EPHA6_ENST00000470610.2_Missense_Mutation_p.G213E	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	118						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						TGGGTCTTGGGGACTTGCAAA	0.398000													45	88					0	0	1	0	0
ZNF670	93474	broad.mit.edu	37	1	247201647	247201647	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:247201647G>A	ENST00000366503.2	-	4	432	c.274C>T	c.(274-276)Ctg>Ttg	p.L92L		NM_001204220.1|NM_033213.4	NP_001191149.1|NP_149990.1	Q9BS34	ZN670_HUMAN	zinc finger protein 670	92					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	17	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00427)			TTCTTATTCAGATTCAAATTT	0.383000													47	87					0	0	1	0	0
NCEH1	57552	broad.mit.edu	37	3	172351831	172351831	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:172351831A>C	ENST00000475381.1	-	5	894	c.661T>G	c.(661-663)Tat>Gat	p.Y221D	NCEH1_ENST00000538775.1_Missense_Mutation_p.Y261D|NCEH1_ENST00000543711.1_Missense_Mutation_p.Y88D|NCEH1_ENST00000273512.3_Missense_Mutation_p.Y253D			Q6PIU2	NCEH1_HUMAN	neutral cholesterol ester hydrolase 1	221					lipid catabolic process	endoplasmic reticulum|integral to membrane|microsome	carboxylesterase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(4)|prostate(1)|skin(1)	15						AGAACTGGATAAATTAAAGCT	0.373000													18	30					0	0	1	0	0
RIMS1	22999	broad.mit.edu	37	6	72945378	72945378	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr6:72945378C>T	ENST00000264839.7	+	8	1804	c.1804C>T	c.(1804-1806)Ctt>Ttt	p.L602F	RIMS1_ENST00000517827.1_Missense_Mutation_p.L61F|RIMS1_ENST00000348717.5_Missense_Mutation_p.L602F|RIMS1_ENST00000523963.1_Missense_Mutation_p.L76F|RIMS1_ENST00000522291.1_Missense_Mutation_p.L602F|RIMS1_ENST00000425662.2_5'UTR|RIMS1_ENST00000521978.1_Missense_Mutation_p.L602F|RIMS1_ENST00000520567.1_Missense_Mutation_p.L602F|RIMS1_ENST00000401910.3_Missense_Mutation_p.L76F|RIMS1_ENST00000518273.1_Missense_Mutation_p.L602F|RIMS1_ENST00000491071.2_Missense_Mutation_p.L602F|RIMS1_ENST00000517960.1_Missense_Mutation_p.L602F			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	602					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				ACGTGTTATTCTTAACAAGAG	0.368000													7	3					0	0	1	0	0
PTGES3L-AARSD1	100885850	broad.mit.edu	37	17	41108328	41108328	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:41108328G>A	ENST00000421990.2	-	11	1423	c.1078C>T	c.(1078-1080)Cgg>Tgg	p.R360W	PTGES3L-AARSD1_ENST00000360221.4_Missense_Mutation_p.R299W|PTGES3L-AARSD1_ENST00000409103.1_Missense_Mutation_p.R269W|PTGES3L-AARSD1_ENST00000409399.1_Missense_Mutation_p.R360W|AARSD1_ENST00000427569.2_Missense_Mutation_p.R186W	NM_001136042.2	NP_001129514.2																					GGCAAACCCCGGCCACTCACC	0.542000													30	37					0	0	1	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20489461	20489461	+	RNA	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr15:20489461C>T	ENST00000555186.1	+	0	449					NR_038836.1																						AACACAACTTCATTCCTAAAG	0.428000													7	31					0	0	1	0	0
GOLGA2P9	440518	broad.mit.edu	37	19	22785641	22785641	+	RNA	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:22785641C>T	ENST00000600260.1	+	0	1648					NR_033899.1																						GGAGCAGCACCGAGAGGAGGA	0.667000													9	25					0	0	1	0	0
FCHO2	115548	broad.mit.edu	37	5	72370607	72370607	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr5:72370607C>T	ENST00000430046.2	+	20	1734	c.1618C>T	c.(1618-1620)Cag>Tag	p.Q540*	FCHO2_ENST00000341845.6_Nonsense_Mutation_p.Q540*|FCHO2_ENST00000512348.1_Nonsense_Mutation_p.Q507*	NM_001146032.1|NM_138782.2	NP_001139504.1|NP_620137.2	Q0JRZ9	FCHO2_HUMAN	FCH domain only 2	540										cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|prostate(1)	17		Lung NSC(167;0.0465)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;4.6e-53)		CCTTGGAAATCAGGATACCTT	0.378000													16	11					0	0	1	0	0
PLD2	5338	broad.mit.edu	37	17	4711379	4711379	+	Silent	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr17:4711379G>A	ENST00000263088.6	+	3	341	c.210G>A	c.(208-210)gtG>gtA	p.V70V	PLD2_ENST00000572940.1_Silent_p.V70V	NM_001243108.1|NM_002663.4	NP_001230037.1|NP_002654.3	O14939	PLD2_HUMAN	phospholipase D2	70	PX.				cell communication|cytoskeleton organization|small GTPase mediated signal transduction		NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)	31					Choline(DB00122)	CCCAGGTGGTGGGCACCGAAA	0.632000													41	62					0	0	1	0	0
KIAA1324	57535	broad.mit.edu	37	1	109714590	109714590	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:109714590C>T	ENST00000369939.3	+	4	753	c.570C>T	c.(568-570)aaC>aaT	p.N190N	KIAA1324_ENST00000529753.1_Silent_p.N190N	NM_020775.4	NP_065826.2	Q6UXG2	K1324_HUMAN	KIAA1324	190					macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		GCACCGTTAACTTCGAATACT	0.542000													58	106					0	0	1	0	0
TPH2	121278	broad.mit.edu	37	12	72338092	72338092	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:72338092G>A	ENST00000333850.3	+	3	415	c.274G>A	c.(274-276)Gtt>Att	p.V92I	TPH2_ENST00000546576.1_3'UTR	NM_173353.3	NP_775489.2	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	92	ACT.				aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	41					L-Tryptophan(DB00150)	TGTCAACATGGTTCATATTGA	0.408000													25	51					0	0	1	0	0
NPSR1	387129	broad.mit.edu	37	7	34889186	34889186	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr7:34889186A>G	ENST00000381539.3	+	10	1139	c.1135A>G	c.(1135-1137)Atc>Gtc	p.I379V	NPSR1_ENST00000359791.1_Intron|NPSR1_ENST00000531252.1_Intron|NPSR1_ENST00000381542.1_Silent_p.R279R|NPSR1_ENST00000360581.1_Silent_p.R345R			Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	0						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	GGGAGCAAAGATCACAGGATT	0.428000													47	85					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24885107	24885107	+	Silent	SNP	C	C	T			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr14:24885107C>T	ENST00000382554.3	+	9	4470	c.4152C>T	c.(4150-4152)ctC>ctT	p.L1384L		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1384					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						TCTTCAGCCTCCTGTGGGAGC	0.627000													46	84					0	0	1	0	0
GPCPD1	56261	broad.mit.edu	37	20	5545700	5545700	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr20:5545700G>A	ENST00000379019.4	-	15	1504	c.1292C>T	c.(1291-1293)tCc>tTc	p.S431F	GPCPD1_ENST00000481038.1_5'UTR	NM_019593.3	NP_062539.1	Q9NPB8	GPCP1_HUMAN	glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)	431	GDPD.				glycerol metabolic process|lipid metabolic process		carbohydrate binding|glycerophosphodiester phosphodiesterase activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)|skin(1)	16						TTCTGAAAAGGAATTTTCCTC	0.323000													30	56					0	0	1	0	0
PTBP2	58155	broad.mit.edu	37	1	97270403	97270420	+	In_Frame_Del	DEL	GCAGCTGCTGCAGCTGCT	GCAGCTGCTGCAGCTGCT	-	rs491654		TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr1:97270403_97270420delGCAGCTGCTGCAGCTGCT	ENST00000236228.6	+	9	1034_1051	c.952_969delGCAGCTGCTGCAGCTGCT	c.(952-969)del	p.AAAAAA318del	PTBP2_ENST00000426398.2_In_Frame_Del_p.AAAAAA318del|PTBP2_ENST00000482253.1_3'UTR|PTBP2_ENST00000370197.1_In_Frame_Del_p.AAAAAA323del|PTBP2_ENST00000394184.3_In_Frame_Del_p.AAAAAA334del|PTBP2_ENST00000541987.1_In_Frame_Del_p.AAAAAA287del|PTBP2_ENST00000370198.1_In_Frame_Del_p.AAAAAA323del	NM_021190.2	NP_067013.1	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	318	Poly-Ala.						nucleotide binding	p.A322V(1)		central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|skin(1)	26		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		tgctgctgcagcagctgctgcagctgctgctgGCCGAG	0.450													25	32	---	---	---	---					
IGSF10	285313	broad.mit.edu	37	3	151160920	151160920	+	Frame_Shift_Del	DEL	T	T	-			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr3:151160920delT	ENST00000282466.3	-	5	5814	c.5815delA	c.(5815-5817)ccfs	p.T1939fs		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	1939					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CTGGGGCTGGTCACTCGCTCT	0.498													56	98	---	---	---	---					
EBF2	64641	broad.mit.edu	37	8	25747315	25747315	+	Frame_Shift_Del	DEL	T	T	-			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr8:25747315delT	ENST00000520164.1	-	8	1241	c.704delA	c.(703-705)acfs	p.N236fs	EBF2_ENST00000408929.3_Frame_Shift_Del_p.N88fs	NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	236	Interaction with DNA (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		CTTGGAGTTGTTATGAACAAA	0.463													37	47	---	---	---	---					
CISD1	55847	broad.mit.edu	37	10	60036937	60036960	+	In_Frame_Del	DEL	ACAAAAGATTTTATGTTAAAGATC	ACAAAAGATTTTATGTTAAAGATC	-			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr10:60036937_60036960delACAAAAGATTTTATGTTAAAGATC	ENST00000333926.5	+	2	308_331	c.92_115delACAAAAGATTTTATGTTAAAGATC	c.(91-117)tat>t	p.YKRFYVKDH31del	CISD1_ENST00000488388.2_3'UTR	NM_018464.4	NP_060934.1	Q9NZ45	CISD1_HUMAN	CDGSH iron sulfur domain 1	31						integral to membrane|mitochondrial outer membrane	2 iron, 2 sulfur cluster binding|metal ion binding			breast(1)	1						TATCTAGCTTACAAAAGATTTTATGTTAAAGATCATCGAAATAA	0.379													15	43	---	---	---	---					
NRBF2	29982	broad.mit.edu	37	10	64913690	64913690	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr10:64913690delA	ENST00000277746.6	+	4	757	c.576delA	c.(574-576)ttfs	p.L192fs	NRBF2_ENST00000435510.2_Frame_Shift_Del_p.L182fs	NM_030759.3	NP_110386.2	Q96F24	NRBF2_HUMAN	nuclear receptor binding factor 2	192					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	cytoplasm|nucleoplasm	protein binding			large_intestine(2)|lung(3)|skin(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					ATGAAAGATTAAGGAAAGAAA	0.383													14	23	---	---	---	---					
ARID2	196528	broad.mit.edu	37	12	46205267	46205282	+	Frame_Shift_Del	DEL	TCCAAAGCCACAGCTT	TCCAAAGCCACAGCTT	-	rs138168440	by1000genomes	TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:46205267_46205282delTCCAAAGCCACAGCTT	ENST00000334344.6	+	4	523_538	c.351_366delTCCAAAGCCACAGCTT	c.(349-366)aafs	p.NPKPQL117fs	ARID2_ENST00000422737.1_5'UTR	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	117					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		CACCAGGCAATCCAAAGCCACAGCTTCCTATTGGTG	0.398			"""N, S, F"""		hepatocellular carcinoma								10	26	---	---	---	---					
ARID2	196528	broad.mit.edu	37	12	46287206	46287218	+	Frame_Shift_Del	DEL	GCCAACTGTAGGG	GCCAACTGTAGGG	-	rs11553485		TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr12:46287206_46287218delGCCAACTGTAGGG	ENST00000334344.6	+	19	5323_5335	c.5151_5163delGCCAACTGTAGGG	c.(5149-5163)cafs	p.QPTVG1717fs	ARID2_ENST00000444670.1_Frame_Shift_Del_p.QPTVG1327fs|ARID2_ENST00000457135.1_Frame_Shift_Del_p.QPTVG325fs|ARID2_ENST00000479608.1_3'UTR|ARID2_ENST00000422737.1_Frame_Shift_Del_p.QPTVG1568fs	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1717					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		AATTTAGGCAGCCAACTGTAGGGGGCACAAGCT	0.479			"""N, S, F"""		hepatocellular carcinoma								8	13	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102293062	102293064	+	RNA	DEL	CTC	CTC	-	rs4965539		TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr15:102293062_102293064delCTC	ENST00000561463.1	+	0	1108_1110																											AGTTCATCTTCTCAGAGCTGCTG	0.576													2	4	---	---	---	---					
FAM192A	80011	broad.mit.edu	37	16	57206236	57206238	+	In_Frame_Del	DEL	TCA	TCA	-			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr16:57206236_57206238delTCA	ENST00000309137.8	-	4	531_533	c.273_275delTGA	c.(271-276)gag>ga	p.DE91del	FAM192A_ENST00000564108.1_In_Frame_Del_p.DE91del|FAM192A_ENST00000566077.1_In_Frame_Del_p.DE14del|FAM192A_ENST00000389447.5_In_Frame_Del_p.DE91del|FAM192A_ENST00000569266.1_In_Frame_Del_p.DE91del|FAM192A_ENST00000567439.1_In_Frame_Del_p.DE91del	NM_024946.2	NP_079222.1	Q9GZU8	F192A_HUMAN	family with sequence similarity 192, member A	91						nucleus				endometrium(2)|large_intestine(3)|lung(4)|prostate(2)	11						TCGAGAAACCTCATCAAGGAAGT	0.379													22	47	---	---	---	---					
KMT2B	9757	broad.mit.edu	37	19	36224124	36224124	+	Frame_Shift_Del	DEL	C	C	-			TCGA-D3-A5GL-06A-11D-A27K-08	TCGA-D3-A5GL-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c62ed25-d935-4c22-af1b-266892c073ae	b6a886dc-bac5-433c-b507-9118579ac647	g.chr19:36224124delC	ENST00000420124.1	+	28	6674	c.6674delC	c.(6673-6675)tcfs	p.S2225fs	KMT2B_ENST00000607650.1_RNA|WBP7_ENST00000222270.7_Frame_Shift_Del_p.S2225fs																							CCCACCATTTCCCCCACGGCT	0.672													2	4	---	---	---	---					
