Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NYAP2	57624	broad.mit.edu	37	2	226446804	226446804	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:226446804G>A	ENST00000272907.6	+	4	1084	c.671G>A	c.(670-672)cGg>cAg	p.R224Q	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	224																	TCGCTGCCGCGGGACTCCTCC	0.592000													32	298					0	0	0.000409698	0	0
SNX29P2	440352	broad.mit.edu	37	16	29367206	29367206	+	RNA	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr16:29367206C>T	ENST00000398878.3	+	0	1032				SNX29P2_ENST00000507381.1_RNA																							TGGGCCGGGGCCGCACCTGGC	0.652000													14	13					0	0	0.00074312	0	0
MGAM	8972	broad.mit.edu	37	7	141803218	141803218	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr7:141803218C>T	ENST00000475668.2	+	70	8217	c.8163C>T	c.(8161-8163)ttC>ttT	p.F2721F	MGAM_ENST00000549489.2_Silent_p.F1825F			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1825					polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CACCCTCCTTCAACAATGACC	0.502000													10	15					0	0	0.000978159	0	0
CDC42EP3	10602	broad.mit.edu	37	2	37873383	37873383	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:37873383T>A	ENST00000295324.3	-	2	1348	c.348A>T	c.(346-348)caA>caT	p.Q116H	AC006369.2_ENST00000419425.1_RNA	NM_001270436.1|NM_001270437.1|NM_001270438.1|NM_006449.3	NP_001257365.1|NP_001257366.1|NP_001257367.1|NP_006440.2	Q9UKI2	BORG2_HUMAN	CDC42 effector protein (Rho GTPase binding) 3	116					regulation of cell shape|signal transduction	actin cytoskeleton|cytoplasm|endomembrane system|membrane	cytoskeletal regulatory protein binding			endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)|prostate(1)	11		all_hematologic(82;0.172)				ACATGAGAGCTTGGGATCCTC	0.557000													22	88					0	0	0.000229342	0	0
OS9	10956	broad.mit.edu	37	12	58114030	58114030	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr12:58114030G>A	ENST00000315970.7	+	13	1790	c.1749G>A	c.(1747-1749)gaG>gaA	p.E583E	OS9_ENST00000389146.6_Silent_p.E568E|OS9_ENST00000257966.8_Intron|RP11-571M6.7_ENST00000549477.1_RNA|OS9_ENST00000439210.2_Intron|OS9_ENST00000551035.1_Intron|OS9_ENST00000389142.5_Intron|OS9_ENST00000413095.2_Intron|OS9_ENST00000552285.1_Intron|OS9_ENST00000435406.2_Intron	NM_001017958.2|NM_006812.3	NP_001017958.1|NP_006803.1	Q13438	OS9_HUMAN	osteosarcoma amplified 9, endoplasmic reticulum lectin	583					ER-associated protein catabolic process|protein retention in ER lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress	endoplasmic reticulum lumen|Hrd1p ubiquitin ligase complex	glycoprotein binding|protein binding|sugar binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	21	all_neural(12;0.00548)|Glioma(12;0.0126)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			TGGAGAGGGAGGGACTCACAG	0.632000													18	30					0	0	0.000132079	0	0
KMT2D	8085	broad.mit.edu	37	12	49425221	49425221	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr12:49425221G>A	ENST00000301067.7	-	39	13266	c.13267C>T	c.(13267-13269)Cca>Tca	p.P4423S		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		AGGGCACATGGCTCTTCCCGA	0.622000													14	20					0	0	0.000219431	0	0
GPR98	84059	broad.mit.edu	37	5	90084111	90084111	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr5:90084111A>T	ENST00000405460.2	+	68	13973	c.13877A>T	c.(13876-13878)aAa>aTa	p.K4626I	GPR98_ENST00000425867.2_Missense_Mutation_p.K287I	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	4626					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TCCAGAGCTAAAGATGTTACA	0.299000													15	48					0	0	0.000422831	0	0
JMJD1C	221037	broad.mit.edu	37	10	65024429	65024429	+	Silent	SNP	A	A	G			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr10:65024429A>G	ENST00000399262.2	-	3	647	c.429T>C	c.(427-429)agT>agC	p.S143S	JMJD1C_ENST00000402544.1_Intron|JMJD1C_ENST00000489372.2_5'UTR|JMJD1C_ENST00000399251.1_5'UTR|JMJD1C_ENST00000542921.1_5'UTR	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	143					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					GCTGAAAGGCACTATCTTCAG	0.313000													17	49					0	0	0.000566183	0	0
CCDC38	120935	broad.mit.edu	37	12	96311013	96311013	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr12:96311013C>T	ENST00000344280.3	-	4	755	c.198G>A	c.(196-198)atG>atA	p.M66I		NM_182496.2	NP_872302.2	Q502W7	CCD38_HUMAN	coiled-coil domain containing 38	66										breast(1)|endometrium(2)|large_intestine(3)|lung(9)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						AATGACTCTTCATTCTGGATG	0.378000													15	22					0	0	0.000308642	0	0
NELL1	4745	broad.mit.edu	37	11	21135260	21135260	+	Splice_Site	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr11:21135260G>A	ENST00000298925.5	+	14	1663	c.1510_splice	c.e14+1	p.E504_splice	NELL1_ENST00000532434.1_Splice_Site_p.E476_splice|NELL1_ENST00000357134.5_Splice_Site_p.E476_splice|NELL1_ENST00000325319.5_Splice_Site_p.E419_splice			Q92832	NELL1_HUMAN	NEL-like 1 (chicken)	476	EGF-like 3.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			NS(1)|breast(3)|endometrium(5)|kidney(3)|large_intestine(15)|lung(36)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	70						CTCTTGTACAGGTGAGCTTTA	0.393000													13	28					0	0	0.000219431	0	0
ZNF614	80110	broad.mit.edu	37	19	52521669	52521669	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr19:52521669G>A	ENST00000270649.6	-	3	638	c.94C>T	c.(94-96)Ctg>Ttg	p.L32L	ZNF614_ENST00000356322.6_Silent_p.L32L	NM_025040.3	NP_079316.2	Q8N883	ZN614_HUMAN	zinc finger protein 614	32	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	24		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00513)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		TCCCGGTACAGGTTCTTCTGA	0.502000													36	33					0	0	0.00058488	0	0
CAP2	10486	broad.mit.edu	37	6	17543150	17543150	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr6:17543150C>T	ENST00000229922.2	+	10	1617	c.1085C>T	c.(1084-1086)tCa>tTa	p.S362L	CAP2_ENST00000493172.1_Missense_Mutation_p.S102L|CAP2_ENST00000489374.1_Missense_Mutation_p.S250L|CAP2_ENST00000465994.1_Missense_Mutation_p.S298L|CAP2_ENST00000378990.2_Missense_Mutation_p.S336L	NM_006366.2	NP_006357.1	P40123	CAP2_HUMAN	CAP, adenylate cyclase-associated protein, 2 (yeast)	362	C-CAP/cofactor C-like.				activation of adenylate cyclase activity|axon guidance|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction	plasma membrane	actin binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(4)|urinary_tract(1)	27	Breast(50;0.0333)|Ovarian(93;0.0386)	all_hematologic(90;0.0466)	all cancers(50;0.194)|Epithelial(50;0.227)			TGCGAAAAATCAACTATTCAG	0.338000													48	81					0	0	0.000781405	0	0
PIK3CA	5290	broad.mit.edu	37	3	178921433	178921433	+	Silent	SNP	A	A	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr3:178921433A>T	ENST00000263967.3	+	5	1072	c.915A>T	c.(913-915)ccA>ccT	p.P305P		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	305					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TTACAATGCCATCTTATTCCA	0.368000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			26	103					0	0	0.00106085	0	0
CYP4Z1	199974	broad.mit.edu	37	1	47548050	47548050	+	Missense_Mutation	SNP	C	C	T	rs146576339	byFrequency	TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:47548050C>T	ENST00000334194.3	+	4	412	c.409C>T	c.(409-411)Cgc>Tgc	p.R137C		NM_178134.2	NP_835235.1	Q86W10	CP4Z1_HUMAN	cytochrome P450, family 4, subfamily Z, polypeptide 1	137						endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			cervix(1)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	11						GAAAAAGCACCGCCAGATTGT	0.448000													24	15					0	0	0.000586117	0	0
ABCA6	23460	broad.mit.edu	37	17	67132222	67132222	+	Silent	SNP	T	T	C			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr17:67132222T>C	ENST00000590645.1	-	4	659	c.471A>G	c.(469-471)ccA>ccG	p.P157P	ABCA6_ENST00000284425.2_Intron			Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	0					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					ATATTTGATATGGAAAGTCAC	0.333000													9	42					0	0	0.000274275	0	0
PIGV	55650	broad.mit.edu	37	1	27121634	27121634	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:27121634C>T	ENST00000374145.1	+	3	1791	c.1109C>T	c.(1108-1110)cCc>cTc	p.P370L	PIGV_ENST00000078527.4_Missense_Mutation_p.P370L|PIGV_ENST00000449950.2_Missense_Mutation_p.P142L	NM_001202554.1	NP_001189483.1	Q9NUD9	PIGV_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class V	370					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	glycolipid mannosyltransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)	14		all_cancers(24;3.93e-26)|all_epithelial(13;3.96e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.26e-54)|Epithelial(14;2.85e-53)|OV - Ovarian serous cystadenocarcinoma(117;1.91e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000504)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.0222)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.153)|LUSC - Lung squamous cell carcinoma(448;0.227)		CTAGAGAAGCCCGATCTTGGA	0.542000													74	46					0	0	0.000781405	0	0
AQP3	360	broad.mit.edu	37	9	33442339	33442339	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr9:33442339G>A	ENST00000297991.4	-	5	750	c.670C>T	c.(670-672)Ctt>Ttt	p.L224F	AQP3_ENST00000493581.1_5'UTR	NM_004925.4	NP_004916.1	Q92482	AQP3_HUMAN	aquaporin 3 (Gill blood group)	224					excretion|odontogenesis|positive regulation of immune system process|regulation of keratinocyte differentiation|response to calcium ion|response to retinoic acid|response to vitamin D	basolateral plasma membrane|cell-cell junction|cytoplasm	glycerol channel activity|water channel activity			endometrium(2)|large_intestine(3)|lung(2)|ovary(1)	8			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.0899)		GCTGTAAAAAGGCGGGGGCCA	0.662000													15	9					0	0	0.00074312	0	0
PTK2B	2185	broad.mit.edu	37	8	27295002	27295002	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr8:27295002C>T	ENST00000397501.1	+	22	2324	c.1516C>T	c.(1516-1518)Ccc>Tcc	p.P506S	PTK2B_ENST00000397497.4_Missense_Mutation_p.P252S|PTK2B_ENST00000544172.1_Missense_Mutation_p.P506S|PTK2B_ENST00000346049.5_Missense_Mutation_p.P506S|PTK2B_ENST00000338238.4_Missense_Mutation_p.P506S|PTK2B_ENST00000420218.2_Missense_Mutation_p.P506S|PTK2B_ENST00000517339.1_Missense_Mutation_p.P506S	NM_173174.2	NP_775266.1	Q14289	FAK2_HUMAN	protein tyrosine kinase 2 beta	506	Protein kinase.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(17)|ovary(4)|skin(12)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		GGAATTGTATCCCTATGGGGA	0.562000													12	14					0	0	0.000219431	0	0
TRANK1	9881	broad.mit.edu	37	3	36898030	36898030	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr3:36898030C>T	ENST00000301807.6	-	12	3298	c.1401G>A	c.(1399-1401)gtG>gtA	p.V467V	TRANK1_ENST00000428977.2_Silent_p.V467V|TRANK1_ENST00000429976.2_Silent_p.V1017V	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1017					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						TGAGGTCGATCACCGCGTACT	0.537000													55	80					0	0	0.000781405	0	0
KCNK9	51305	broad.mit.edu	37	8	140631316	140631316	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr8:140631316C>T	ENST00000520439.1	-	2	373	c.310G>A	c.(310-312)Gat>Aat	p.D104N	KCNK9_ENST00000303015.1_Missense_Mutation_p.D104N			Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	104						integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			NS(1)|endometrium(9)|kidney(1)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)	43	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			TTGCCCGCATCGGTGCCAGGT	0.612000													8	20					0	0	0.000274275	0	0
ZFP64	55734	broad.mit.edu	37	20	50768918	50768918	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr20:50768918T>C	ENST00000216923.4	-	6	2162	c.1813A>G	c.(1813-1815)Acc>Gcc	p.T605A	ZFP64_ENST00000346617.4_Missense_Mutation_p.T551A|ZFP64_ENST00000361387.2_Intron|ZFP64_ENST00000477786.1_Intron|ZFP64_ENST00000371515.4_Missense_Mutation_p.T603A|ZFP64_ENST00000371518.2_Intron	NM_018197.2|NM_199426.1	NP_060667.2|NP_955458.1	Q9NPA5	ZF64A_HUMAN	ZFP64 zinc finger protein	605					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(5)|large_intestine(8)|lung(11)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	33						CCCGAACTGGTAATGAAAGTT	0.562000													14	91					0	0	0.000308642	0	0
KCNH7	90134	broad.mit.edu	37	2	163374414	163374414	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:163374414G>A	ENST00000332142.5	-	4	817	c.718C>T	c.(718-720)Ccc>Tcc	p.P240S	KCNH7_ENST00000477019.1_5'UTR|KCNH7_ENST00000328032.4_Missense_Mutation_p.P240S	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	240					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	TGCCTTTTGGGAGAGGAATGG	0.498000													5	8					0	0	3.59834e-05	0	0
OR2T33	391195	broad.mit.edu	37	1	248436865	248436865	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:248436865C>T	ENST00000318021.2	-	1	273	c.252G>A	c.(250-252)ttG>ttA	p.L84L		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	84					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TACTTCCGGTCAAGTAGTCAG	0.577000													35	114					0	0	0.000953801	0	0
RSPH3	83861	broad.mit.edu	37	6	159398873	159398873	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr6:159398873G>A	ENST00000367069.2	-	8	1590	c.954C>T	c.(952-954)atC>atT	p.I318I	RSPH3_ENST00000252655.1_Silent_p.I460I|RSPH3_ENST00000449822.1_Silent_p.I222I|RSPH3_ENST00000297262.3_Silent_p.I364I			Q86UC2	RSPH3_HUMAN	radial spoke 3 homolog (Chlamydomonas)	460								p.I460I(1)		endometrium(3)|kidney(2)|large_intestine(1)|lung(7)|ovary(2)|skin(1)|stomach(7)	23		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.36e-16)|BRCA - Breast invasive adenocarcinoma(81;5.92e-06)		CCACCTCACGGATCAACACTG	0.408000													53	34					0	0	0.000781405	0	0
PFKFB4	5210	broad.mit.edu	37	3	48563046	48563046	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr3:48563046G>A	ENST00000232375.3	-	10	1156	c.1044C>T	c.(1042-1044)ttC>ttT	p.F348F	PFKFB4_ENST00000490115.1_5'UTR|PFKFB4_ENST00000416568.1_Silent_p.F341F|PFKFB4_ENST00000541519.1_Silent_p.F314F|PFKFB4_ENST00000545984.1_3'UTR|PFKFB4_ENST00000536104.1_Silent_p.F337F|PFKFB4_ENST00000383734.2_Intron	NM_004567.2	NP_004558.1	Q16877	F264_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	348	Fructose-2,6-bisphosphatase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|urinary_tract(1)	14				BRCA - Breast invasive adenocarcinoma(193;0.0003)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		CCCGCAGGGCGAACTCCAGTG	0.562000													13	20					0	0	0.000422831	0	0
LRP6	4040	broad.mit.edu	37	12	12334021	12334021	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr12:12334021C>T	ENST00000261349.4	-	6	1405	c.1329G>A	c.(1327-1329)gaG>gaA	p.E443E	LRP6_ENST00000543091.1_Silent_p.E443E	NM_002336.2	NP_002327.2	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein 6	443	Beta-propeller 2.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding	p.E443D(1)		breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				CCTCTAAGTCCTCTGAAATCA	0.448000													146	227					0	0	0.000781405	0	0
DDX3X	1654	broad.mit.edu	37	X	41204721	41204721	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chrX:41204721C>T	ENST00000399959.2	+	12	2090	c.1235C>T	c.(1234-1236)tCt>tTt	p.S412F	DDX3X_ENST00000457138.2_Missense_Mutation_p.S396F|DDX3X_ENST00000441189.2_Intron|DDX3X_ENST00000542215.1_3'UTR|DDX3X_ENST00000478993.1_3'UTR	NM_001193416.1|NM_001193417.1|NM_001356.3	NP_001180345.1|NP_001180346.1|NP_001347.3	O00571	DDX3X_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked	412	Necessary for interaction with XPO1.				interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding	p.S412F(2)		NS(3)|breast(8)|central_nervous_system(36)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84						GGCTCTACCTCTGAAAACATC	0.353000										HNSCC(61;0.18)			40	13					0	0	0.000781405	0	0
RHOV	171177	broad.mit.edu	37	15	41165488	41165488	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr15:41165488C>T	ENST00000220507.4	-	3	628	c.479G>A	c.(478-480)gGg>gAg	p.G160E		NM_133639.3	NP_598378.3	Q96L33	RHOV_HUMAN	ras homolog family member V	160					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome membrane|plasma membrane	GTP binding|metal ion binding			central_nervous_system(1)|large_intestine(1)	2		all_cancers(109;1.42e-13)|all_epithelial(112;1.48e-11)|Lung NSC(122;5.77e-09)|all_lung(180;1.08e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.58e-05)|COAD - Colon adenocarcinoma(120;0.149)|BRCA - Breast invasive adenocarcinoma(123;0.163)		CTCCCGGCCCCCCTGGTCCAG	0.662000													18	66					0	0	0.000132079	0	0
PCDHA9	9752	broad.mit.edu	37	5	140389311	140389311	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr5:140389311C>T	ENST00000532602.1	+	4	3675	c.2642C>T	c.(2641-2643)cCc>cTc	p.P881L	PCDHA10_ENST00000506939.2_Missense_Mutation_p.P616L|PCDHA7_ENST00000525929.1_Missense_Mutation_p.P868L|PCDHA5_ENST00000529619.1_Missense_Mutation_p.P867L|PCDHA4_ENST00000512229.2_Missense_Mutation_p.P878L|PCDHA8_ENST00000531613.1_Missense_Mutation_p.P881L|PCDHA11_ENST00000398640.2_Missense_Mutation_p.P880L|PCDHA5_ENST00000529859.1_Missense_Mutation_p.P867L|PCDHA6_ENST00000527624.1_Missense_Mutation_p.P617L|PCDHA1_ENST00000504120.2_Missense_Mutation_p.P881L|PCDHA10_ENST00000307360.5_Missense_Mutation_p.P879L|PCDHA13_ENST00000409494.1_Missense_Mutation_p.P881L|PCDHA4_ENST00000530339.1_Missense_Mutation_p.P878L|PCDHA13_ENST00000289272.2_Missense_Mutation_p.P881L|PCDHA6_ENST00000529310.1_Missense_Mutation_p.P881L|PCDHA2_ENST00000526136.1_Missense_Mutation_p.P879L|PCDHAC2_ENST00000289269.5_Missense_Mutation_p.P938L|PCDHAC1_ENST00000253807.2_Missense_Mutation_p.P894L|PCDHA12_ENST00000398631.2_Missense_Mutation_p.P872L|PCDHA3_ENST00000522353.2_Missense_Mutation_p.P881L|PCDHA1_ENST00000394633.3_Missense_Mutation_p.P617L	NM_031857.1	NP_114063.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAATCCGGTCCCGGTGAGTTG	0.522000													26	39					0	0	0.000878237	0	0
DCHS2	54798	broad.mit.edu	37	4	155158041	155158041	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr4:155158041G>A	ENST00000357232.3	-	25	6397	c.6398C>T	c.(6397-6399)tCc>tTc	p.S2133F		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	2133	Cadherin 19.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		ACTGATGATGGAATATTCAAC	0.383000													20	11					0	0	0.000958276	0	0
PCLO	27445	broad.mit.edu	37	7	82585181	82585181	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr7:82585181C>T	ENST00000423517.2	-	5	5425	c.5088G>A	c.(5086-5088)gaG>gaA	p.E1696E	PCLO_ENST00000333891.8_Silent_p.E1696E	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1627					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CCAATTCTGGCTCTTCGTCAA	0.428000													14	27					0	0	0.000219431	0	0
CRIM1	51232	broad.mit.edu	37	2	36691751	36691751	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:36691751G>T	ENST00000280527.2	+	5	1311	c.944G>T	c.(943-945)gGc>gTc	p.G315V		NM_016441.2	NP_057525.1	Q9NZV1	CRIM1_HUMAN	cysteine rich transmembrane BMP regulator 1 (chordin-like)	315					nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(15)|liver(2)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	45		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				GTCTCTCGTGGCGATGGGACA	0.498000													26	128					1.66031e-10	2.19363e-09	0.000586117	1	0
OR5B3	441608	broad.mit.edu	37	11	58170611	58170611	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr11:58170611G>A	ENST00000309403.2	-	1	271	c.272C>T	c.(271-273)tCt>tTt	p.S91F		NM_001005469.1	NP_001005469.1	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B, member 3	91					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S91C(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(1)	34	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TGCATTGTAAGAGATGACCTT	0.433000													20	41					0	0	0.000295444	0	0
KRTAP4-8	728224	broad.mit.edu	37	17	39253944	39253944	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr17:39253944G>A	ENST00000333822.4	-	1	449	c.393C>T	c.(391-393)atC>atT	p.I131I		NM_031960.2	NP_114166.1	Q9BYQ9	KRA48_HUMAN	keratin associated protein 4-8	131	25 X 5 AA repeats of C-C-[IKRQVHEC]- [SPRT]-[STCVQPR].					keratin filament				endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|prostate(1)	11						agcagctggagatgctgcagc	0.672000													13	1					0	0	0.000151284	0	0
ZNF799	90576	broad.mit.edu	37	19	12503428	12503428	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr19:12503428C>T	ENST00000419318.1	-	3	833	c.84G>A	c.(82-84)agG>agA	p.R28R	ZNF799_ENST00000430385.3_Silent_p.R60R|CTD-3105H18.14_ENST00000435033.1_Intron|ZNF799_ENST00000595766.1_3'UTR|CTD-3105H18.16_ENST00000595562.1_Silent_p.R60R			Q96GE5	ZN799_HUMAN	zinc finger protein 799	60	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(2)	19						TTAGATTTTTCCTGGGATATC	0.294000													26	31					0	0	0.00106085	0	0
SMARCAL1	50485	broad.mit.edu	37	2	217279882	217279882	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:217279882C>T	ENST00000357276.4	+	3	785	c.455C>T	c.(454-456)cCt>cTt	p.P152L	SMARCAL1_ENST00000358207.5_Missense_Mutation_p.P152L	NM_014140.3	NP_054859.2	Q9NZC9	SMAL1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1	152					chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(10)|liver(1)|lung(15)|ovary(3)|prostate(1)|skin(1)	42		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		CAGGCTTCACCTGAGATCAGG	0.512000									Schimke Immuno-Osseous Dysplasia				131	43					0	0	0.000781405	0	0
RGS22	26166	broad.mit.edu	37	8	101014456	101014456	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr8:101014456G>A	ENST00000360863.6	-	18	2958	c.2764C>T	c.(2764-2766)Cca>Tca	p.P922S	RGS22_ENST00000523437.1_Missense_Mutation_p.P910S|RGS22_ENST00000523287.1_Missense_Mutation_p.P741S	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	922	RGS 1.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			AGAGAAGCTGGACTGTTGGGT	0.323000													19	45					0	0	0.000295444	0	0
RFX7	64864	broad.mit.edu	37	15	56386859	56386859	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr15:56386859G>A	ENST00000423270.1	-	9	3066	c.3067C>T	c.(3067-3069)Ccg>Tcg	p.P1023S	RFX7_ENST00000422057.1_Missense_Mutation_p.P926S|RFX7_ENST00000317318.6_Missense_Mutation_p.P1023S|RFX7_ENST00000559447.2_Missense_Mutation_p.P926S	NM_022841.5	NP_073752.5	Q2KHR2	RFX7_HUMAN	regulatory factor X, 7	926					regulation of transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						AATGCAAACGGATTCCTGCAT	0.493000													13	19					0	0	0.00010058	0	0
GNE	10020	broad.mit.edu	37	9	36233983	36233983	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr9:36233983G>A	ENST00000396594.3	-	5	1120	c.1009C>T	c.(1009-1011)Cga>Tga	p.R337*	GNE_ENST00000543356.2_Nonsense_Mutation_p.R301*|GNE_ENST00000447283.2_Nonsense_Mutation_p.R306*|GNE_ENST00000377902.5_Nonsense_Mutation_p.R306*|GNE_ENST00000539208.1_Nonsense_Mutation_p.R196*|GNE_ENST00000539815.1_Nonsense_Mutation_p.R306*	NM_001128227.2	NP_001121699.1	Q9Y223	GLCNE_HUMAN	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	306					cell adhesion|lipopolysaccharide biosynthetic process|N-acetylneuraminate metabolic process|UDP-N-acetylglucosamine metabolic process		ATP binding|N-acylmannosamine kinase activity|UDP-N-acetylglucosamine 2-epimerase activity			endometrium(8)|kidney(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			STAD - Stomach adenocarcinoma(86;0.228)			CCAACTTCTCGAACCCCACAG	0.463000													74	66					0	0	0.000781405	0	0
PCK1	5105	broad.mit.edu	37	20	56139563	56139563	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr20:56139563G>A	ENST00000535860.1	+	5	1015	c.904G>A	c.(904-906)Gag>Aag	p.E302K	PCK1_ENST00000543666.1_Silent_p.S87S|PCK1_ENST00000319441.4_Silent_p.S404S			P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	6					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			ACCCCAACTCGAGGTTCTGCA	0.587000													37	94					0	0	0.00111076	0	0
SDR16C5	195814	broad.mit.edu	37	8	57228744	57228744	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr8:57228744G>A	ENST00000396721.2	-	2	293	c.163C>T	c.(163-165)Ctc>Ttc	p.L55F	SDR16C5_ENST00000303749.3_Missense_Mutation_p.L55F|SDR16C5_ENST00000522671.1_Missense_Mutation_p.L55F			Q8N3Y7	RDHE2_HUMAN	short chain dehydrogenase/reductase family 16C, member 5	55					detection of light stimulus involved in visual perception|keratinocyte proliferation|retinal metabolic process|retinol metabolic process	endoplasmic reticulum membrane|integral to membrane|integral to membrane of membrane fraction	binding|retinol dehydrogenase activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(1)	16						AAGGCTAAGAGCCTTCCGAGT	0.502000													26	38					0	0	0.00047179	0	0
ITGB2	3689	broad.mit.edu	37	21	46323297	46323297	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr21:46323297G>A	ENST00000397850.2	-	6	934	c.482C>T	c.(481-483)aCc>aTc	p.T161I	ITGB2_ENST00000397852.1_Missense_Mutation_p.T161I|ITGB2_ENST00000397857.1_Missense_Mutation_p.T161I|ITGB2_ENST00000302347.5_Missense_Mutation_p.T161I|ITGB2_ENST00000397854.3_Intron|ITGB2_ENST00000355153.4_Missense_Mutation_p.T161I			P05107	ITB2_HUMAN	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	161	VWFA.				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(6)|lung(14)|ovary(4)|skin(3)	35				Colorectal(79;0.0669)	Simvastatin(DB00641)	GCCGGACTCGGTGATCTCGTT	0.597000													32	46					0	0	0.000491102	0	0
ETV1	2115	broad.mit.edu	37	7	13935665	13935665	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr7:13935665G>A	ENST00000343495.5	-	13	1944	c.1206C>T	c.(1204-1206)gcC>gcT	p.A402A	ETV1_ENST00000403527.1_Silent_p.A380A|ETV1_ENST00000430479.1_Silent_p.A420A|ETV1_ENST00000399357.3_Silent_p.A317A|ETV1_ENST00000405358.4_Silent_p.A434A|ETV1_ENST00000405218.2_Silent_p.A420A|ETV1_ENST00000405192.2_Silent_p.A397A|ETV1_ENST00000403685.1_Silent_p.A402A|ETV1_ENST00000242066.5_Silent_p.A402A|ETV1_ENST00000420159.2_Silent_p.A362A			P50549	ETV1_HUMAN	ets variant 1	420					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(34)|ACSL3_ENST00000357430/ETV1(2)|EWSR1/ETV1(7)|KLK2/ETV1(3)|SLC45A3/ETV1(3)|HNRNPA2B1/ETV1(8)	breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31						TGGAGAAAAGGGCTTCTGGAT	0.483000			T	"""EWSR1, TMPRSS2, SLC45A3, C15orf21, HNRNPA2B1. ACSL3"""	"""Ewing sarcoma, prostate"""								15	16					0	0	0.000566183	0	0
TTN	7273	broad.mit.edu	37	2	179579149	179579149	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:179579149C>T	ENST00000589042.1	-	91	26576	c.26352G>A	c.(26350-26352)tgG>tgA	p.W8784*	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342992.6_Nonsense_Mutation_p.W7540*|TTN_ENST00000591111.1_Nonsense_Mutation_p.W8467*|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8467	Ig-like 70.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATAAGAAATCCATATGTTGT	0.413000													9	18					0	0	0.000442599	0	0
WBSCR17	64409	broad.mit.edu	37	7	71177002	71177002	+	Splice_Site	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr7:71177002G>A	ENST00000333538.5	+	11	2302		c.e11-1		WBSCR17_ENST00000498380.2_Splice_Site	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17							Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				CCCCCTCCCAGAATGGAGCCA	0.562000													46	49					0	0	0.000781405	0	0
SDK2	54549	broad.mit.edu	37	17	71380034	71380034	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr17:71380034G>A	ENST00000392650.3	-	33	4686	c.4686C>T	c.(4684-4686)gcC>gcT	p.A1562A	SDK2_ENST00000388726.3_Silent_p.A1562A	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	1562	Fibronectin type-III 10.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						CAGCCCATGTGGCCCCTGGGT	0.602000													21	55					0	0	0.000586117	0	0
CTD-2587H24.4	0	broad.mit.edu	37	19	55670814	55670814	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr19:55670814G>A	ENST00000587871.1	-	4	225	c.226C>T	c.(226-228)Cct>Tct	p.P76S	DNAAF3_ENST00000524407.2_Silent_p.Y414Y|DNAAF3_ENST00000455045.1_Silent_p.Y360Y|DNAAF3_ENST00000527223.2_Silent_p.Y481Y|DNAAF3_ENST00000587789.2_5'UTR|DNAAF3_ENST00000391720.4_Silent_p.Y461Y|CTD-2587H24.5_ENST00000591665.1_RNA																							CGTCCACCAGGTACCTGCAGA	0.627000													13	53					0	0	0.000308642	0	0
AQP5	362	broad.mit.edu	37	12	50355884	50355884	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr12:50355884C>T	ENST00000293599.6	+	1	232	c.84C>T	c.(82-84)ggC>ggT	p.G28G	RP11-469H8.6_ENST00000552379.1_RNA|RP11-469H8.6_ENST00000550530.1_RNA|RP11-469H8.6_ENST00000550214.1_RNA	NM_001651.2	NP_001642.1	P55064	AQP5_HUMAN	aquaporin 5	28					carbon dioxide transport|excretion|odontogenesis|pancreatic juice secretion	apical plasma membrane|integral to plasma membrane	protein binding|water channel activity			large_intestine(1)|lung(3)	4						TCTTCTTTGGCCTGGGCTCGG	0.667000													12	22					0	0	0.000308642	0	0
WNT7A	7476	broad.mit.edu	37	3	13860703	13860703	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr3:13860703G>A	ENST00000285018.4	-	4	1092	c.788C>T	c.(787-789)cCc>cTc	p.P263L		NM_004625.3	NP_004616.2	O00755	WNT7A_HUMAN	wingless-type MMTV integration site family, member 7A	263					activation of JUN kinase activity|anterior/posterior pattern formation|canonical Wnt receptor signaling pathway|cell proliferation in forebrain|cellular response to transforming growth factor beta stimulus|central nervous system vasculogenesis|cerebellar granule cell differentiation|dorsal/ventral pattern formation|embryonic axis specification|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic leg morphogenesis|lens fiber cell development|negative regulation of neurogenesis|palate development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of JNK cascade|positive regulation of synaptogenesis|positive regulation of transcription from RNA polymerase II promoter|regulation of axon diameter|satellite cell activation|satellite cell maintenance involved in skeletal muscle regeneration|sex differentiation|uterus development|Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled binding|receptor agonist activity|signal transducer activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	24						CGTGTCCATGGGCTTGCGGTA	0.627000													38	69					0	0	0.000589545	0	0
CHD5	26038	broad.mit.edu	37	1	6181563	6181563	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:6181563C>T	ENST00000262450.3	-	32	4869	c.4770G>A	c.(4768-4770)ctG>ctA	p.L1590L	CHD5_ENST00000378021.1_Silent_p.L447L	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1590					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CCTGGACTTCCAGGGGCTGCC	0.587000													19	6					0	0	0.000175454	0	0
NHLRC4	283948	broad.mit.edu	37	16	618191	618191	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr16:618191C>T	ENST00000424439.2	+	2	801	c.144C>T	c.(142-144)ttC>ttT	p.F48F	NHLRC4_ENST00000540585.1_Silent_p.F48F|PIGQ_ENST00000409527.2_Intron			P0CG21	NHLC4_HUMAN	NHL repeat containing 4	48																	GGCACACTTTCGGCTGCCCAG	0.652000													6	17					0	0	8.12818e-05	0	0
HEG1	57493	broad.mit.edu	37	3	124689608	124689608	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr3:124689608C>T	ENST00000311127.4	-	17	4101	c.4034G>A	c.(4033-4035)gGa>gAa	p.G1345E		NM_020733.1	NP_065784.1	Q9ULI3	HEG1_HUMAN	heart development protein with EGF-like domains 1	1345						extracellular region|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(24)|ovary(2)|urinary_tract(4)	47						CGGGTAGAGTCCGTTTCGTTC	0.438000													5	8					0	0	3.59834e-05	0	0
GTF2IRD2B	389524	broad.mit.edu	37	7	74564144	74564144	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr7:74564144C>A	ENST00000312575.7	+	16	2066	c.1891C>A	c.(1891-1893)Ctt>Att	p.L631I	GTF2IRD2B_ENST00000418185.2_Missense_Mutation_p.L178I	NM_001003795.2	NP_001003795.1	Q6EKJ0	GTD2B_HUMAN	GTF2I repeat domain containing 2B	631					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|ovary(2)|prostate(1)	4						caataacgggcttgtcacaaa	0.507000													9	57					4.36969e-10	5.75927e-09	0.000151284	1	0
FAM83A	84985	broad.mit.edu	37	8	124195541	124195541	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr8:124195541G>A	ENST00000518448.1	+	2	2459	c.445G>A	c.(445-447)Gac>Aac	p.D149N	FAM83A_ENST00000522648.1_Missense_Mutation_p.D149N|FAM83A_ENST00000536633.1_Missense_Mutation_p.D149N|FAM83A_ENST00000276699.6_Missense_Mutation_p.D149N|FAM83A_ENST00000546351.1_Missense_Mutation_p.D149N|FAM83A_ENST00000318462.6_Missense_Mutation_p.D149N			Q86UY5	FA83A_HUMAN	family with sequence similarity 83, member A	149										breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(3)|prostate(2)|skin(1)	17	Lung NSC(37;1.55e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			CAACATCAGAGACCTCGTCCG	0.597000													20	35					0	0	0.000958276	0	0
ASXL2	55252	broad.mit.edu	37	2	25990459	25990459	+	Silent	SNP	G	G	C			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:25990459G>C	ENST00000435504.4	-	8	1061	c.768C>G	c.(766-768)ctC>ctG	p.L256L	ASXL2_ENST00000404843.1_5'UTR|ASXL2_ENST00000336112.4_Silent_p.L228L|ASXL2_ENST00000272341.4_5'UTR			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	256					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TACTGGTATGGAGTCTCTCAG	0.393000													29	51					0	0	0.000409698	0	0
PPP3CA	5530	broad.mit.edu	37	4	101961690	101961690	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr4:101961690C>T	ENST00000394854.3	-	11	1873	c.1190G>A	c.(1189-1191)aGg>aAg	p.R397K	PPP3CA_ENST00000523694.2_Missense_Mutation_p.R330K|PPP3CA_ENST00000394853.4_Missense_Mutation_p.R397K|PPP3CA_ENST00000507176.1_Missense_Mutation_p.R299K|PPP3CA_ENST00000323055.6_Missense_Mutation_p.R355K|PPP3CA_ENST00000512215.1_Missense_Mutation_p.R165K	NM_000944.4	NP_000935.1	Q08209	PP2BA_HUMAN	protein phosphatase 3, catalytic subunit, alpha isozyme	397	Calmodulin-binding (Potential).				protein dephosphorylation	calcineurin complex|cytosol|nucleus	calcium ion binding|calmodulin binding			breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	20				OV - Ovarian serous cystadenocarcinoma(123;6.79e-08)		GATCTTGTTCCTTATCACCTC	0.393000													8	29					0	0	0.000274275	0	0
ESPNP	284729	broad.mit.edu	37	1	17030538	17030538	+	RNA	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:17030538C>T	ENST00000492551.1	-	0	797					NR_026567.1																						AGTTCAGAGGCTGGACCGACA	0.632000													6	71					0	0	3.59834e-05	0	0
METTL22	79091	broad.mit.edu	37	16	8729067	8729067	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr16:8729067C>T	ENST00000381920.3	+	5	856	c.598C>T	c.(598-600)Cga>Tga	p.R200*	METTL22_ENST00000568967.1_3'UTR|METTL22_ENST00000561758.1_Nonsense_Mutation_p.R144*	NM_024109.2	NP_077014.2	Q9BUU2	MET22_HUMAN	methyltransferase like 22	200							methyltransferase activity			large_intestine(5)|lung(4)	9						CATCCTGTTCCGACAGGACCT	0.637000													27	29					0	0	0.000720815	0	0
TRPM6	140803	broad.mit.edu	37	9	77407629	77407629	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr9:77407629C>T	ENST00000451710.3	-	19	2686	c.2449G>A	c.(2449-2451)Ggt>Agt	p.G817S	TRPM6_ENST00000376872.3_Intron|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000360774.1_Missense_Mutation_p.G817S|TRPM6_ENST00000449912.2_Missense_Mutation_p.G812S|TRPM6_ENST00000376864.4_Missense_Mutation_p.G817S|TRPM6_ENST00000361255.3_Missense_Mutation_p.G812S			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	817					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						CTTTCCAAACCAAAATGCTGA	0.388000													26	13					0	0	0.000878237	0	0
ECE2	9718	broad.mit.edu	37	3	183967612	183967612	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr3:183967612G>A	ENST00000402825.3	+	1	130	c.130G>A	c.(130-132)Gac>Aac	p.D44N	ECE2_ENST00000324557.4_Missense_Mutation_p.D44N|EIF2B5_ENST00000444495.1_Intron	NM_014693.3	NP_055508.3	O60344	ECE2_HUMAN	endothelin converting enzyme 2	44	Methyltransferase-like region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TTGGTTCGGGGACTTCTCCTC	0.652000											OREG0015944	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	34					0	0	0.000692331	0	0
SCN9A	6335	broad.mit.edu	37	2	167134676	167134676	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:167134676A>C	ENST00000375387.4	-	15	2834	c.2494T>G	c.(2494-2496)Ttg>Gtg	p.L832V	SCN9A_ENST00000409435.1_Missense_Mutation_p.L831V|AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000409672.1_Missense_Mutation_p.L820V|SCN9A_ENST00000303354.6_Missense_Mutation_p.L832V			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	831						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	AGAACTGACAATCCTTCCACA	0.343000													7	26					0	0	0.000442599	0	0
HAPLN1	1404	broad.mit.edu	37	5	82948428	82948428	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr5:82948428C>T	ENST00000274341.4	-	3	1166	c.316G>A	c.(316-318)Gga>Aga	p.G106R	HAPLN1_ENST00000514416.1_Missense_Mutation_p.G106R	NM_001884.3	NP_001875.1	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	106	Ig-like V-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|liver(1)|lung(15)|ovary(1)|prostate(1)|skin(1)	34		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		TGGTAGCCTCCATAGGTTTTT	0.433000													14	68					0	0	0.000422831	0	0
BAI3	577	broad.mit.edu	37	6	70065728	70065728	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr6:70065728G>A	ENST00000370598.1	+	28	4392	c.3571G>A	c.(3571-3573)Gat>Aat	p.D1191N	BAI3_ENST00000238918.8_Missense_Mutation_p.D397N|BAI3_ENST00000546190.1_Missense_Mutation_p.D155N	NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1191					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				CTTTGAAAAGGATGTAGACAT	0.284000													48	47					0	0	0.000781405	0	0
CEP350	9857	broad.mit.edu	37	1	180068003	180068003	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:180068003C>T	ENST00000367607.3	+	37	9490	c.9072C>T	c.(9070-9072)ttC>ttT	p.F3024F	CEP350_ENST00000490141.1_3'UTR	NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	3024						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						CACAGAGCTTCATAGCAAGTG	0.353000													8	38					0	0	0.000442599	0	0
HTRA1	5654	broad.mit.edu	37	10	124273856	124273856	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr10:124273856C>T	ENST00000368984.3	+	9	1552	c.1424C>T	c.(1423-1425)cCc>cTc	p.P475L		NM_002775.4	NP_002766.1	Q92743	HTRA1_HUMAN	HtrA serine peptidase 1	475					proteolysis|regulation of cell growth	extracellular space	insulin-like growth factor binding|serine-type endopeptidase activity			endometrium(1)|kidney(1)|large_intestine(8)|lung(7)	17		all_neural(114;0.0765)|Lung NSC(174;0.133)|all_lung(145;0.163)|Breast(234;0.238)				ACAGTGATTCCCGAAGAAATT	0.507000													14	55					0	0	0.000422831	0	0
TOMM40L	84134	broad.mit.edu	37	1	161198560	161198560	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:161198560C>T	ENST00000367988.3	+	9	1009	c.740C>T	c.(739-741)tCc>tTc	p.S247F	TOMM40L_ENST00000545897.1_Missense_Mutation_p.S213F|TOMM40L_ENST00000367987.1_Missense_Mutation_p.S247F|TOMM40L_ENST00000474486.1_3'UTR	NM_032174.4	NP_115550.2	Q969M1	TM40L_HUMAN	translocase of outer mitochondrial membrane 40 homolog (yeast)-like	247					protein transport	mitochondrial outer membrane|pore complex	porin activity|voltage-gated anion channel activity			large_intestine(2)|liver(4)|lung(4)	10	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			ACAACATTCTCCTTTGGTTAC	0.493000													9	36					0	0	0.000978159	0	0
NBPF1	55672	broad.mit.edu	37	1	16895719	16895719	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:16895719C>T	ENST00000430580.2	-	23	3350	c.2463G>A	c.(2461-2463)gaG>gaA	p.E821E	NBPF1_ENST00000420031.2_3'UTR|NBPF1_ENST00000287968.8_3'UTR|NBPF1_ENST00000432949.1_Intron	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	821	NBPF 4.|Poly-Glu.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		CCTCTTCAGACTCCTGCAGAT	0.488000													11	163					0	0	0.000151284	0	0
RFX6	222546	broad.mit.edu	37	6	117248363	117248363	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr6:117248363C>T	ENST00000332958.2	+	17	2075	c.2059C>T	c.(2059-2061)Ccc>Tcc	p.P687S		NM_173560.3	NP_775831.2	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	687					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(29)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	59						GCCCATTTATCCCACTCTCCC	0.522000													23	27					0	0	0.000295444	0	0
OR4D9	390199	broad.mit.edu	37	11	59283084	59283084	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr11:59283084G>A	ENST00000329328.3	+	1	699	c.699G>A	c.(697-699)agG>agA	p.R233R		NM_001004711.1	NP_001004711.1	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D, member 9	233					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|prostate(5)|upper_aerodigestive_tract(1)	26						GGGAAGGCAGGAGGAAAGCCA	0.512000													65	92					0	0	0.000781405	0	0
TNN	63923	broad.mit.edu	37	1	175066699	175066699	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:175066699G>A	ENST00000239462.4	+	8	1848	c.1735G>A	c.(1735-1737)Ggg>Agg	p.G579R		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	579	Fibronectin type-III 4.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GGTTCTGGTGGGGAAGGAGCA	0.607000													11	34					0	0	0.000151284	0	0
DUOXA1	90527	broad.mit.edu	37	15	45413409	45413409	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr15:45413409G>A	ENST00000267803.4	-	6	615	c.216C>T	c.(214-216)ttC>ttT	p.F72F	DUOXA1_ENST00000558996.1_Intron|DUOXA1_ENST00000430224.2_Intron|DUOXA1_ENST00000558422.1_Intron|DUOXA1_ENST00000559014.1_Silent_p.F72F|DUOXA1_ENST00000560572.1_Silent_p.F72F	NM_144565.2	NP_653166.2	Q1HG43	DOXA1_HUMAN	dual oxidase maturation factor 1	72					protein transport	endoplasmic reticulum membrane|integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	16		all_cancers(109;6.02e-08)|all_epithelial(112;1.83e-06)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.82e-18)|GBM - Glioblastoma multiforme(94;4.39e-07)|COAD - Colon adenocarcinoma(120;0.0676)|Colorectal(133;0.0686)		ACTCAGAACTGAAATTCACAG	0.512000													12	23					0	0	0.000151284	0	0
DIDO1	11083	broad.mit.edu	37	20	61511949	61511949	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr20:61511949C>T	ENST00000266070.4	-	16	5684	c.5359G>A	c.(5359-5361)Gct>Act	p.A1787T	DIDO1_ENST00000395343.1_Missense_Mutation_p.A1787T	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1787	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					TCGTTAGAAGCGATATTCTCT	0.617000													15	173					0	0	0.000566183	0	0
SDR16C5	195814	broad.mit.edu	37	8	57228829	57228829	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr8:57228829C>T	ENST00000396721.2	-	2	208	c.78G>A	c.(76-78)atG>atA	p.M26I	SDR16C5_ENST00000303749.3_Missense_Mutation_p.M26I|SDR16C5_ENST00000522671.1_Missense_Mutation_p.M26I			Q8N3Y7	RDHE2_HUMAN	short chain dehydrogenase/reductase family 16C, member 5	26					detection of light stimulus involved in visual perception|keratinocyte proliferation|retinal metabolic process|retinol metabolic process	endoplasmic reticulum membrane|integral to membrane|integral to membrane of membrane fraction	binding|retinol dehydrogenase activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(1)	16						AGGCAAAAATCATAGCCTCCA	0.448000													22	32					0	0	0.000295444	0	0
ZNF33A	7581	broad.mit.edu	37	10	38345158	38345158	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr10:38345158C>T	ENST00000374618.3	+	5	2284	c.2106C>T	c.(2104-2106)ttC>ttT	p.F702F	ZNF33A_ENST00000307441.9_Silent_p.F701F|ZNF33A_ENST00000432900.2_Silent_p.F708F|ZNF33A_ENST00000458705.2_Silent_p.F701F|ZNF33A_ENST00000469037.2_Intron	NM_001278170.1|NM_001278171.1|NM_001278173.1|NM_001278174.1|NM_001278175.1|NM_001278176.1|NM_001278177.1|NM_001278178.1|NM_001278179.1|NM_006954.1|NM_006974.2	NP_001265099.1|NP_001265100.1|NP_001265102.1|NP_001265103.1|NP_001265104.1|NP_001265105.1|NP_001265106.1|NP_001265107.1|NP_001265108.1|NP_008885.1|NP_008905.1	Q06730	ZN33A_HUMAN	zinc finger protein 33A	701						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(8)|liver(2)|lung(27)|ovary(2)|prostate(1)|skin(2)	46						GGAAATTCTTCAGGCACAAAT	0.393000													25	18					0	0	0.00047179	0	0
C6orf15	29113	broad.mit.edu	37	6	31079351	31079351	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr6:31079351C>T	ENST00000259870.3	-	2	788	c.785G>A	c.(784-786)gGa>gAa	p.G262E		NM_014070.2	NP_054789.2	Q6UXA7	CF015_HUMAN	chromosome 6 open reading frame 15	262	Gly-rich.									endometrium(3)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|stomach(1)	17						ATTAATATTTCCCCAGCTGCC	0.502000													7	102					0	0	0.000157383	0	0
KIF1C	10749	broad.mit.edu	37	17	4923933	4923933	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr17:4923933G>A	ENST00000320785.5	+	20	2254	c.1897G>A	c.(1897-1899)Gag>Aag	p.E633K	KIF1C_ENST00000573815.1_3'UTR	NM_006612.5	NP_006603.2	O43896	KIF1C_HUMAN	kinesin family member 1C	633					microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(4)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|skin(1)|urinary_tract(3)	30						GGAACTGCTGGAGCAGCAAGG	0.652000													22	8					0	0	0.000229342	0	0
HDAC7	51564	broad.mit.edu	37	12	48189006	48189006	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr12:48189006G>A	ENST00000080059.7	-	11	1244	c.1245C>T	c.(1243-1245)ccC>ccT	p.P415P	HDAC7_ENST00000354334.3_Silent_p.P378P|HDAC7_ENST00000380610.4_Silent_p.P432P|HDAC7_ENST00000427332.2_Silent_p.P376P|HDAC7_ENST00000552960.1_Silent_p.P398P	NM_015401.3	NP_056216.2	Q8WUI4	HDAC7_HUMAN	histone deacetylase 7	376	Transcription repression 2 (By similarity).				negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25				GBM - Glioblastoma multiforme(48;0.137)		GCTCCAGGCGGGGCTGCATGG	0.647000													37	56					0	0	0.000509022	0	0
NFKBIB	4793	broad.mit.edu	37	19	39396030	39396030	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr19:39396030C>T	ENST00000392079.3	+	3	476	c.378C>T	c.(376-378)ccC>ccT	p.P126P	NFKBIB_ENST00000313582.5_Silent_p.P158P|NFKBIB_ENST00000572515.1_Silent_p.P158P			Q15653	IKBB_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	158					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleus	protein binding|signal transducer activity|transcription coactivator activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)	8	all_cancers(60;4.39e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			GGGAAGCCCCCGACACCTACC	0.687000													4	13					0	0	0.00024832	0	0
SLC24A3	57419	broad.mit.edu	37	20	19261652	19261652	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr20:19261652G>A	ENST00000328041.6	+	2	389	c.192G>A	c.(190-192)gcG>gcA	p.A64A	RP5-1027G4.3_ENST00000319682.2_RNA	NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	64						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						GGATGATGGCGAGGAAGCTGA	0.522000													31	8					0	0	0.000339439	0	0
NAV1	89796	broad.mit.edu	37	1	201750396	201750396	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:201750396C>T	ENST00000367296.4	+	5	2042	c.1622C>T	c.(1621-1623)tCc>tTc	p.S541F	NAV1_ENST00000295624.6_Missense_Mutation_p.S541F|NAV1_ENST00000367300.3_Missense_Mutation_p.S541F|NAV1_ENST00000367302.1_Missense_Mutation_p.S554F|NAV1_ENST00000367297.4_Missense_Mutation_p.S541F|IPO9-AS1_ENST00000413035.1_RNA|NAV1_ENST00000367295.1_Missense_Mutation_p.S150F	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	541					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						GCTGTAACTTCCCCCATCACT	0.537000													5	24					0	0	0.000602214	0	0
PDZRN4	29951	broad.mit.edu	37	12	41967311	41967311	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr12:41967311C>G	ENST00000298919.7	+	10	2338	c.1950C>G	c.(1948-1950)atC>atG	p.I650M	PDZRN4_ENST00000402685.2_Missense_Mutation_p.I910M|PDZRN4_ENST00000539469.2_Missense_Mutation_p.I652M			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	910				S -> G (in Ref. 1 and 2; BAD18688).			ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				GAGACCGAATCCTGAAGGAAC	0.517000													19	29					0	0	0.00074312	0	0
CNTN2	6900	broad.mit.edu	37	1	205033866	205033866	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:205033866C>T	ENST00000331830.4	+	12	1791	c.1507C>T	c.(1507-1509)Cta>Tta	p.L503L		NM_005076.3	NP_005067.1	Q02246	CNTN2_HUMAN	contactin 2 (axonal)	503	Ig-like C2-type 5.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(11)|lung(23)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	54	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CACTGGAATCCTATCTGTGCG	0.547000													19	94					0	0	0.000175454	0	0
PHACTR3	116154	broad.mit.edu	37	20	58381145	58381145	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr20:58381145G>A	ENST00000371015.1	+	8	1691	c.1224G>A	c.(1222-1224)agG>agA	p.R408R	PHACTR3_ENST00000395639.4_Silent_p.R297R|PHACTR3_ENST00000361300.4_Silent_p.R297R|PHACTR3_ENST00000355648.4_Silent_p.R367R|PHACTR3_ENST00000359926.3_Silent_p.R405R|PHACTR3_ENST00000541461.1_Silent_p.R367R|PHACTR3_ENST00000395636.2_Silent_p.R367R	NM_080672.3	NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	408						nuclear matrix	actin binding|protein phosphatase inhibitor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			TGAAGCTAAGGAACCGGCCAA	0.517000													136	115					0	0	0.000781405	0	0
C6	729	broad.mit.edu	37	5	41181509	41181509	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr5:41181509G>A	ENST00000263413.3	-	7	1143	c.879C>T	c.(877-879)atC>atT	p.I293I	C6_ENST00000475349.1_5'UTR|C6_ENST00000337836.5_Silent_p.I293I	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	293	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding	p.I293I(1)		central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				AATTATGGTTGATATTTTCAC	0.358000													25	82					0	0	0.000878237	0	0
ABCC11	85320	broad.mit.edu	37	16	48227838	48227838	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr16:48227838C>T	ENST00000394747.1	-	18	2809	c.2460G>A	c.(2458-2460)acG>acA	p.T820T	ABCC11_ENST00000394748.1_Silent_p.T820T|ABCC11_ENST00000353782.5_Silent_p.T820T|ABCC11_ENST00000356608.2_Silent_p.T820T|ABCC11_ENST00000537808.1_3'UTR	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	820	ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				AGCTGAAGATCGTTAAGAAGA	0.527000													32	8					0	0	0.000953801	0	0
RELN	5649	broad.mit.edu	37	7	103175777	103175777	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr7:103175777G>A	ENST00000424685.2	-	46	7494	c.7335C>T	c.(7333-7335)ctC>ctT	p.L2445L	RELN_ENST00000428762.1_Silent_p.L2445L|RELN_ENST00000343529.5_Silent_p.L2445L			P78509	RELN_HUMAN	reelin	2445					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TATAAGGAGGGAGAGGCAGAG	0.453000													9	18					0	0	0.000978159	0	0
SDK1	221935	broad.mit.edu	37	7	3990576	3990576	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr7:3990576C>T	ENST00000404826.2	+	6	1008	c.869C>T	c.(868-870)aCc>aTc	p.T290I	SDK1_ENST00000389531.3_Missense_Mutation_p.T290I	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	290					cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		ACACCTGAAACCATGGCCCCA	0.552000													13	35					0	0	0.000422831	0	0
MYO3B	140469	broad.mit.edu	37	2	171256757	171256757	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:171256757C>T	ENST00000334231.6	+	17	1878	c.1878C>T	c.(1876-1878)ttC>ttT	p.F626F	MYO3B_ENST00000408978.4_Silent_p.F617F|MYO3B_ENST00000409044.3_Silent_p.F617F|MYO3B_ENST00000602629.1_3'UTR			Q8WXR4	MYO3B_HUMAN	myosin IIIB	617	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						ACATTGAGTTCGCAGCTATTT	0.403000													63	72					0	0	0.000781405	0	0
ABCB5	340273	broad.mit.edu	37	7	20683155	20683155	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr7:20683155C>T	ENST00000404938.2	+	7	1230	c.578C>T	c.(577-579)tCg>tTg	p.S193L		NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	379					regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity	p.S193L(1)|p.S193*(1)		breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						TCTACTTTTTCGATTGGCCTG	0.423000													61	114					0	0	0.000781405	0	0
CLCA2	9635	broad.mit.edu	37	1	86905984	86905984	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:86905984C>T	ENST00000370565.4	+	8	1519	c.1357C>T	c.(1357-1359)Ctg>Ttg	p.L453L		NM_006536.5	NP_006527.1	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2	453	VWFA.				cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity	p.L453M(1)		NS(2)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	42		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		AGCCCCAAATCTGGAGGAATT	0.423000													38	22					0	0	0.000270559	0	0
KRT2	3849	broad.mit.edu	37	12	53045889	53045889	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr12:53045889C>T	ENST00000309680.3	-	1	59	c.38G>A	c.(37-39)gGa>gAa	p.G13E		NM_000423.2	NP_000414.2	P35908	K22E_HUMAN	keratin 2	13	Head.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(18)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32				BRCA - Breast invasive adenocarcinoma(357;0.19)		tccacctcctcctcttcctcG	0.552000													3	8					0	0	0.00024832	0	0
DMBT1	1755	broad.mit.edu	37	10	124395627	124395627	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr10:124395627C>T	ENST00000368909.3	+	50	6388	c.6282C>T	c.(6280-6282)ttC>ttT	p.F2094F	DMBT1_ENST00000338354.3_Silent_p.F2094F|DMBT1_ENST00000368955.3_Silent_p.F2084F|DMBT1_ENST00000344338.3_Silent_p.F2084F|DMBT1_ENST00000330163.4_Silent_p.F1466F|DMBT1_ENST00000359586.6_Silent_p.F814F|DMBT1_ENST00000368956.2_Silent_p.F1466F	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	2094	CUB 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CCTCCAACTTCATGTCCATTC	0.512000													18	17					0	0	0.000566183	0	0
INHBA	3624	broad.mit.edu	37	7	41730107	41730107	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr7:41730107G>A	ENST00000242208.4	-	3	668	c.422C>T	c.(421-423)tCc>tTc	p.S141F	INHBA_ENST00000464515.1_5'UTR|INHBA_ENST00000442711.1_Missense_Mutation_p.S141F|AC005027.3_ENST00000416150.1_RNA	NM_002192.2	NP_002183.1	P08476	INHBA_HUMAN	inhibin, beta A	141					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(15)|lung(26)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						GCCTTCCTTGGAAATCTCGAA	0.507000										TSP Lung(11;0.080)			15	28					0	0	0.000219431	0	0
FN1	2335	broad.mit.edu	37	2	216289995	216289995	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:216289995G>A	ENST00000354785.4	-	7	1227	c.858C>T	c.(856-858)ttC>ttT	p.F286F	FN1_ENST00000421182.1_Silent_p.F286F|FN1_ENST00000359671.1_Silent_p.F286F|FN1_ENST00000357867.4_Silent_p.F286F|FN1_ENST00000357009.2_Silent_p.F286F|FN1_ENST00000356005.4_Silent_p.F286F|FN1_ENST00000345488.5_Silent_p.F286F|FN1_ENST00000336916.4_Silent_p.F286F|FN1_ENST00000323926.6_Silent_p.F286F|FN1_ENST00000346544.3_Silent_p.F286F|FN1_ENST00000426059.1_Silent_p.F286F|FN1_ENST00000446046.1_Silent_p.F286F|FN1_ENST00000443816.1_Silent_p.F286F|FN1_ENST00000432072.2_Silent_p.F286F			P02751	FINC_HUMAN	fibronectin 1	286					acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAACATCGGTGAAGGGGCCAG	0.522000													139	48					0	0	0.000781405	0	0
NBEA	26960	broad.mit.edu	37	13	35733681	35733681	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr13:35733681G>A	ENST00000400445.3	+	22	3907	c.3373G>A	c.(3373-3375)Gat>Aat	p.D1125N	NBEA_ENST00000310336.4_Missense_Mutation_p.D1125N|NBEA_ENST00000379939.2_Missense_Mutation_p.D1125N|NBEA_ENST00000540320.1_Missense_Mutation_p.D1125N	NM_015678.4	NP_056493.3	Q8NFP9	NBEA_HUMAN	neurobeachin	1125						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TGAAGAAAAGGATAATGGTCC	0.343000													10	6					0	0	0.000978159	0	0
DDX18	8886	broad.mit.edu	37	2	118575276	118575276	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:118575276G>C	ENST00000263239.2	+	2	470	c.342G>C	c.(340-342)aaG>aaC	p.K114N	DDX18_ENST00000474694.1_3'UTR	NM_006773.3	NP_006764.3	Q9NVP1	DDX18_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18	114	Poly-Lys.						ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(3)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						AGAAGAAAAAGAGAAAAATGG	0.348000													27	87					0	0	0.000878237	0	0
SLC22A16	85413	broad.mit.edu	37	6	110763784	110763784	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr6:110763784G>A	ENST00000368919.3	-	4	912	c.846C>T	c.(844-846)atC>atT	p.I282I	SLC22A16_ENST00000456137.2_3'UTR|SLC22A16_ENST00000439654.1_Silent_p.I282I|SLC22A16_ENST00000330550.4_Silent_p.I248I	NM_033125.3	NP_149116.2	Q86VW1	S22AG_HUMAN	solute carrier family 22 (organic cation/carnitine transporter), member 16	282					acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	34		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)		AACAGCACAGGATAAAGGGGA	0.488000													22	25					0	0	0.000375601	0	0
KRTAP10-10	353333	broad.mit.edu	37	21	46057641	46057641	+	Missense_Mutation	SNP	G	G	A	rs68027322		TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr21:46057641G>A	ENST00000380095.1	+	1	369	c.307G>A	c.(307-309)Gtc>Atc	p.V103I	TSPEAR_ENST00000323084.4_Intron	NM_181688.1	NP_859016.1	P60014	KR10A_HUMAN	keratin associated protein 10-10	103	15 X 5 AA repeats of C-C-X(3).					keratin filament				NS(1)|endometrium(2)|kidney(1)|lung(6)|prostate(1)|skin(2)	13						ctgtgtgcccgtctgctgcgt	0.622000													40	41					0	0	0.000319135	0	0
DDX39B	7919	broad.mit.edu	37	6	31500583	31500583	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr6:31500583G>A	ENST00000417556.2	-	8	1516	c.886C>T	c.(886-888)Ctt>Ttt	p.L296F	DDX39B_ENST00000415382.2_Missense_Mutation_p.L203F|DDX39B_ENST00000376177.2_Missense_Mutation_p.L281F|DDX39B_ENST00000458640.1_Missense_Mutation_p.L281F|DDX39B_ENST00000396172.1_Missense_Mutation_p.L281F|ATP6V1G2-DDX39B_ENST00000376185.1_3'UTR			Q13838	DX39B_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B	281	Helicase C-terminal.				intronless viral mRNA export from host nucleus|RNA secondary structure unwinding|spliceosome assembly	nuclear speck|spliceosomal complex|transcription export complex	ATP binding|ATP-dependent protein binding|ATP-dependent RNA helicase activity|identical protein binding|U4 snRNA binding|U6 snRNA binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19						ACATCCAGAAGGTCAAAGAGC	0.493000													25	65					0	0	0.000586117	0	0
DNAH10	196385	broad.mit.edu	37	12	124330680	124330680	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr12:124330680G>A	ENST00000409039.3	+	31	5464	c.5439G>A	c.(5437-5439)cgG>cgA	p.R1813R		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1813	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TCACCGATCGGATTTACCTGA	0.582000													7	23					0	0	0.000157383	0	0
CAMSAP2	23271	broad.mit.edu	37	1	200817884	200817884	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:200817884C>T	ENST00000358823.2	+	11	2257	c.1987C>T	c.(1987-1989)Cct>Tct	p.P663S	CAMSAP2_ENST00000413307.2_Missense_Mutation_p.P647S|CAMSAP2_ENST00000236925.4_Missense_Mutation_p.P674S	NM_203459.1	NP_982284.1	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein family, member 2	674						cytoplasm|microtubule	protein binding										AGCTTTGAGTCCTTGTCCAAG	0.418000													45	20					0	0	0.000680045	0	0
NPTXR	23467	broad.mit.edu	37	22	39219117	39219117	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr22:39219117G>A	ENST00000333039.2	-	4	1372	c.1249C>T	c.(1249-1251)Cat>Tat	p.H417Y		NM_014293.3	NP_055108.2	O95502	NPTXR_HUMAN	neuronal pentraxin receptor	417	Pentaxin.					integral to membrane	metal ion binding			central_nervous_system(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14	Melanoma(58;0.04)					AGGATCCCATGAGGCTTGATG	0.602000													28	70					0	0	0.000692331	0	0
SLC6A3	6531	broad.mit.edu	37	5	1441597	1441597	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr5:1441597G>A	ENST00000270349.9	-	3	422	c.295C>T	c.(295-297)Ctg>Ttg	p.L99L	SLC6A3_ENST00000453492.2_Silent_p.L99L	NM_001044.4	NP_001035.1	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 3	99					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				breast(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(19)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	TAGGGGACCAGGAAGGCACCT	0.602000													20	35					0	0	0.000375601	0	0
APCS	325	broad.mit.edu	37	1	159557901	159557901	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:159557901G>A	ENST00000255040.2	+	2	172	c.75G>A	c.(73-75)ggG>ggA	p.G25G		NM_001639.3	NP_001630.1	P02743	SAMP_HUMAN	amyloid P component, serum	25	Pentaxin.				acute-phase response|chaperone-mediated protein complex assembly|protein folding	extracellular space	metal ion binding|sugar binding|unfolded protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(2)	20	all_hematologic(112;0.0429)					ACCTCAGTGGGAAGGTGTTTG	0.393000													43	21					0	0	0.000374591	0	0
NPHS1	4868	broad.mit.edu	37	19	36334398	36334398	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr19:36334398C>T	ENST00000378910.5	-	17	2309	c.2310G>A	c.(2308-2310)ccG>ccA	p.P770P	NPHS1_ENST00000353632.6_Silent_p.P770P	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	770	Ig-like C2-type 7.				cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TGAACATGCCCGGGAGGATGG	0.572000													46	45					0	0	0.000781405	0	0
C1orf65	164127	broad.mit.edu	37	1	223568233	223568233	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:223568233C>T	ENST00000366875.3	+	1	1519	c.1416C>T	c.(1414-1416)cgC>cgT	p.R472R		NM_152610.2	NP_689823.2	Q8N715	CA065_HUMAN	chromosome 1 open reading frame 65	472										breast(4)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|skin(3)	29				GBM - Glioblastoma multiforme(131;0.0704)		AGCGGCAACGCGAGCTGAGGG	0.607000													9	21					0	0	0.000442599	0	0
VCP	7415	broad.mit.edu	37	9	35061054	35061054	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr9:35061054G>A	ENST00000358901.6	-	11	2212	c.1317C>T	c.(1315-1317)gcC>gcT	p.A439A		NM_007126.3	NP_009057.1	P55072	TERA_HUMAN	valosin containing protein	439					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding	p.A439A(1)		breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			TCATGACCTCGGCATCAATGG	0.527000													36	116					0	0	0.000228196	0	0
PI4KA	5297	broad.mit.edu	37	22	21088363	21088363	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr22:21088363G>A	ENST00000255882.6	-	34	4106	c.4020C>T	c.(4018-4020)aaC>aaT	p.N1340N	PI4KA_ENST00000414196.3_Silent_p.N92N|PI4KA_ENST00000572273.1_Silent_p.N1282N	NM_058004.3	NP_477352.3	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase, catalytic, alpha	1282					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(8)|kidney(9)|large_intestine(19)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|salivary_gland(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	79	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			CCACGTGCCGGTTCATGCTCC	0.632000													11	12					0	0	0.00010058	0	0
MYB	4602	broad.mit.edu	37	6	135521533	135521533	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr6:135521533C>A	ENST00000341911.5	+	13	2129	c.1930C>A	c.(1930-1932)Ctg>Atg	p.L644M	MYB_ENST00000533624.1_Missense_Mutation_p.L488M|MYB_ENST00000528774.1_Missense_Mutation_p.L641M|MYB_ENST00000442647.2_Missense_Mutation_p.L520M|MYB_ENST00000525369.1_Missense_Mutation_p.L438M|MYB_ENST00000316528.8_Missense_Mutation_p.L523M|MYB_ENST00000531845.1_3'UTR|MYB_ENST00000367814.4_Missense_Mutation_p.L523M|MYB_ENST00000527615.1_Missense_Mutation_p.L523M|MYB_ENST00000534121.1_Missense_Mutation_p.L628M|MYB_ENST00000534044.1_Missense_Mutation_p.L523M	NM_001130173.1|NM_001161656.1|NM_001161658.1	NP_001123645.1|NP_001155128.1|NP_001155130.1	P10242	MYB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog	538					blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	28	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)		ACCACCCTTACTGAAGAAAAT	0.443000			T	NFIB	adenoid cystic carcinoma								18	35					2.35188e-11	3.12258e-10	0.00074312	1	0
IFITM3	10410	broad.mit.edu	37	11	320742	320742	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr11:320742C>T	ENST00000399808.4	-	1	308	c.72G>A	c.(70-72)aaG>aaA	p.K24K	IFITM3_ENST00000602735.1_Silent_p.K3K|RP11-326C3.11_ENST00000602756.1_RNA|IFITM3_ENST00000526811.1_Silent_p.K3K|RP11-326C3.11_ENST00000602429.1_RNA	NM_021034.2	NP_066362.2	Q01628	IFM3_HUMAN	interferon induced transmembrane protein 3	24					response to virus|type I interferon-mediated signaling pathway	integral to membrane|plasma membrane				central_nervous_system(7)|endometrium(7)|kidney(2)|large_intestine(1)|lung(1)	18		all_cancers(49;2e-09)|all_epithelial(84;3.36e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;8.85e-28)|Epithelial(43;5.52e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		CGTGCTCCTCCTTGAGCATCT	0.632000													52	63					0	0	0.000781405	0	0
FAIM3	9214	broad.mit.edu	37	1	207087397	207087397	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:207087397C>T	ENST00000367091.3	-	2	223	c.80G>A	c.(79-81)gGg>gAg	p.G27E	FAIM3_ENST00000420007.2_Missense_Mutation_p.G27E|FAIM3_ENST00000528654.1_Intron|FAIM3_ENST00000442471.2_Intron	NM_005449.4	NP_005440.1	O60667	FAIM3_HUMAN	Fas apoptotic inhibitory molecule 3	27					anti-apoptosis|cellular defense response	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	15	Breast(84;0.201)					GCCCAGCTCCCCCTCTACCTT	0.547000													51	26					0	0	0.000781405	0	0
PIF1	80119	broad.mit.edu	37	15	65108888	65108888	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr15:65108888C>G	ENST00000268043.4	-	12	1845	c.1751G>C	c.(1750-1752)cGg>cCg	p.R584P	PIF1_ENST00000559239.1_Missense_Mutation_p.R584P|PIF1_ENST00000333425.6_Missense_Mutation_p.R584P			Q9H611	PIF1_HUMAN	PIF1 5'-to-3' DNA helicase	584	Hydrolyzes ATP in the presence of both magnesium and single-stranded DNA; weak activity in the presence of RNA or double-stranded DNA; No unwinding activity.				negative regulation of telomerase activity|regulation of telomere maintenance|viral genome replication	nuclear chromosome, telomeric region	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' DNA/RNA helicase activity|magnesium ion binding|single-stranded DNA-dependent ATP-dependent DNA helicase activity|telomeric DNA binding			kidney(1)|lung(1)	2						GCTGCGGGCCCGAGAAAGGGC	0.642000													13	56					0	0	0.000151284	0	0
APCS	325	broad.mit.edu	37	1	159558413	159558413	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:159558413C>T	ENST00000255040.2	+	2	684	c.587C>T	c.(586-588)cCt>cTt	p.P196L		NM_001639.3	NP_001630.1	P02743	SAMP_HUMAN	amyloid P component, serum	196	Pentaxin.				acute-phase response|chaperone-mediated protein complex assembly|protein folding	extracellular space	metal ion binding|sugar binding|unfolded protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(2)	20	all_hematologic(112;0.0429)					CAGGGTACCCCTCTCCCTGCC	0.502000													19	14					0	0	0.000175454	0	0
VPS53	55275	broad.mit.edu	37	17	440338	440338	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr17:440338C>T	ENST00000437048.2	-	18	2091	c.1945G>A	c.(1945-1947)Gtc>Atc	p.V649I	VPS53_ENST00000574029.1_Intron|VPS53_ENST00000401468.3_Missense_Mutation_p.V372I|VPS53_ENST00000291074.5_Missense_Mutation_p.V620I|VPS53_ENST00000576149.1_5'UTR|VPS53_ENST00000571805.1_Missense_Mutation_p.V649I|VPS53_ENST00000446250.2_Missense_Mutation_p.V451I|RP5-1029F21.4_ENST00000570974.1_RNA	NM_001128159.2	NP_001121631.1	Q5VIR6	VPS53_HUMAN	vacuolar protein sorting 53 homolog (S. cerevisiae)	649					protein transport	endosome membrane|Golgi apparatus				breast(1)|endometrium(4)|large_intestine(5)|lung(8)|prostate(1)	19				UCEC - Uterine corpus endometrioid carcinoma (25;0.0265)		ATGATGGGGACGTTCTGCTTG	0.527000													13	12					0	0	0.000219431	0	0
TMC5	79838	broad.mit.edu	37	16	19455460	19455460	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr16:19455460C>T	ENST00000396229.2	+	4	1595	c.846C>T	c.(844-846)ccC>ccT	p.P282P	TMC5_ENST00000381414.4_Silent_p.P282P|TMC5_ENST00000542583.2_Silent_p.P282P|TMC5_ENST00000541464.1_Silent_p.P282P	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	282						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						GTGATGACCCCGTGGGCAGTC	0.488000													43	45					0	0	0.000589545	0	0
HHATL	57467	broad.mit.edu	37	3	42735116	42735116	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr3:42735116C>T	ENST00000441594.1	-	10	1502	c.1241G>A	c.(1240-1242)cGa>cAa	p.R414Q	HHATL_ENST00000310417.5_Missense_Mutation_p.R414Q	NM_020707.3	NP_065758.3	Q9HCP6	HHATL_HUMAN	hedgehog acyltransferase-like	414					negative regulation of N-terminal protein palmitoylation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(3)|prostate(3)	19				KIRC - Kidney renal clear cell carcinoma(284;0.215)		CACCTCAATTCGTGCTAGGGG	0.577000													10	10					0	0	0.00010058	0	0
CXorf48	54967	broad.mit.edu	37	X	134292130	134292130	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chrX:134292130C>T	ENST00000344129.2	-	4	757	c.531G>A	c.(529-531)acG>acA	p.T177T	CXorf48_ENST00000276241.6_Silent_p.T177T	NM_017863.2	NP_060333.1	Q8WUE5	CX048_HUMAN	chromosome X open reading frame 48	177										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)	5	Acute lymphoblastic leukemia(192;0.000127)					TTACCTCTTCCGTATGAATAC	0.433000													17	7					0	0	0.000566183	0	0
ALMS1	7840	broad.mit.edu	37	2	73677148	73677148	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:73677148C>T	ENST00000264448.6	+	8	3602	c.3491C>T	c.(3490-3492)cCt>cTt	p.P1164L	ALMS1_ENST00000409009.1_Missense_Mutation_p.P1122L|ALMS1_ENST00000377715.1_Missense_Mutation_p.P1164L	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1164	34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						ACTCATATACCTGAAGAGGCT	0.458000													113	53					0	0	0.000781405	0	0
NANOG	79923	broad.mit.edu	37	12	7947353	7947353	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr12:7947353C>T	ENST00000229307.4	+	4	799	c.580C>T	c.(580-582)Cca>Tca	p.P194S	NANOG_ENST00000526286.1_Missense_Mutation_p.P178S	NM_024865.2	NP_079141.2	Q9H9S0	NANOG_HUMAN	Nanog homeobox	194					cell proliferation|embryo development|somatic stem cell maintenance	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	14				Kidney(36;0.0872)		TGGGAACCTTCCAATGTGGAG	0.542000													20	5					0	0	0.000295444	0	0
LRRC56	115399	broad.mit.edu	37	11	541582	541582	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr11:541582G>T	ENST00000270115.7	+	5	723	c.223G>T	c.(223-225)Gag>Tag	p.E75*		NM_198075.3	NP_932341.1	Q8IYG6	LRC56_HUMAN	leucine rich repeat containing 56	75										kidney(1)|lung(4)|skin(1)	6		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GAGGACGCTGGAGATGTGTGT	0.642000													19	31					3.10358e-05	0.000406089	0.000295444	1	0
DNAH17	8632	broad.mit.edu	37	17	76458971	76458971	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr17:76458971C>T	ENST00000389840.5	-	57	9211	c.9087G>A	c.(9085-9087)gaG>gaA	p.E3029E	DNAH17_ENST00000585328.1_Silent_p.E3038E|DNAH17_ENST00000586052.1_5'UTR					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TCTCCAGCCTCTCGATTTTGG	0.582000													22	75					0	0	0.000375601	0	0
TBC1D1	23216	broad.mit.edu	37	4	38091574	38091574	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr4:38091574T>A	ENST00000261439.4	+	13	2427	c.2072T>A	c.(2071-2073)cTt>cAt	p.L691H	TBC1D1_ENST00000508802.1_Missense_Mutation_p.L785H	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	691						nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						CTGGGAGAGCTTCCCCCACGA	0.473000													93	20					0	0	0.000781405	0	0
IQGAP2	10788	broad.mit.edu	37	5	76003063	76003063	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr5:76003063G>A	ENST00000274364.6	+	36	4950	c.4653G>A	c.(4651-4653)atG>atA	p.M1551I	IQGAP2_ENST00000502745.1_Missense_Mutation_p.M1047I|IQGAP2_ENST00000379730.3_Missense_Mutation_p.M1053I|IQGAP2_ENST00000396234.3_Missense_Mutation_p.M1047I|CTD-2384B11.2_ENST00000507514.1_RNA|IQGAP2_ENST00000508410.1_3'UTR	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	1551					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		TAGCTGTAATGAAAATGTTTG	0.308000													7	30					0	0	0.000157383	0	0
PCDHB16	57717	broad.mit.edu	37	5	140562580	140562580	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr5:140562580G>A	ENST00000361016.2	+	1	1601	c.446G>A	c.(445-447)gGa>gAa	p.G149E		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		149	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGTCCTCTAGGAACTGAGTTC	0.393000													31	19					0	0	0.000339439	0	0
SIPA1	6494	broad.mit.edu	37	11	65417243	65417243	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr11:65417243C>T	ENST00000394224.3	+	12	2949	c.2653C>T	c.(2653-2655)Ccc>Tcc	p.P885S	SIPA1_ENST00000394227.3_Missense_Mutation_p.P783S|SIPA1_ENST00000534313.1_Missense_Mutation_p.P885S|SIPA1_ENST00000527525.1_Missense_Mutation_p.P783S	NM_153253.29	NP_694985.29	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated 1	885					cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	10						GCCAGGCAGTCCCAGTGGCTC	0.602000													17	36					0	0	0.000566183	0	0
PEAK1	79834	broad.mit.edu	37	15	77425888	77425888	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr15:77425888C>T	ENST00000560626.2	-	6	4011	c.3536G>A	c.(3535-3537)aGt>aAt	p.S1179N	PEAK1_ENST00000312493.4_Missense_Mutation_p.S1179N			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	1179					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										GACACAAAGACTACTTTCCAT	0.473000													19	126					0	0	0.000958276	0	0
KSR2	283455	broad.mit.edu	37	12	118293345	118293345	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr12:118293345C>T	ENST00000425217.1	-	3	327	c.273G>A	c.(271-273)ttG>ttA	p.L91L	KSR2_ENST00000339824.5_Silent_p.L120L	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	120					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCGTCATCTCCAAGAGGTCCT	0.607000													24	23					0	0	0.00047179	0	0
KCNQ3	3786	broad.mit.edu	37	8	133141661	133141661	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr8:133141661C>T	ENST00000388996.4	-	15	2887	c.2467G>A	c.(2467-2469)Ggg>Agg	p.G823R	KCNQ3_ENST00000519445.1_Missense_Mutation_p.G811R|KCNQ3_ENST00000521134.1_Missense_Mutation_p.G703R	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	823					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			CAGCTCGACCCCCCATTGGGG	0.612000													19	29					0	0	0.000132079	0	0
KIAA1244	57221	broad.mit.edu	37	6	138628449	138628449	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr6:138628449G>A	ENST00000251691.4	+	23	4054	c.3888G>A	c.(3886-3888)tgG>tgA	p.W1296*		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	1296					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		AGTCGGGATGGAGACCCTTGT	0.512000													40	71					0	0	0.000228196	0	0
ZC3HAV1	56829	broad.mit.edu	37	7	138764305	138764305	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr7:138764305C>T	ENST00000242351.5	-	4	1698	c.1382G>A	c.(1381-1383)aGg>aAg	p.R461K	ZC3HAV1_ENST00000471652.1_Missense_Mutation_p.R461K|ZC3HAV1_ENST00000464606.1_Missense_Mutation_p.R461K	NM_020119.3	NP_064504.2	Q7Z2W4	ZCCHV_HUMAN	zinc finger CCCH-type, antiviral 1	461					response to virus	cytoplasm|nucleus	NAD+ ADP-ribosyltransferase activity|RNA binding|zinc ion binding			cervix(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|prostate(4)|skin(1)	37						ATCCTGAATCCTAGGTGATGA	0.438000													32	81					0	0	0.000339439	0	0
EDIL3	10085	broad.mit.edu	37	5	83433158	83433158	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr5:83433158C>T	ENST00000296591.5	-	5	788	c.370G>A	c.(370-372)Gaa>Aaa	p.E124K	EDIL3_ENST00000380138.3_Missense_Mutation_p.E114K	NM_005711.3	NP_005702.3	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like domains 3	124	EGF-like 3.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(5)|skin(3)	31		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		GGCTCAACTTCGCATTCATTT	0.333000													23	39					0	0	0.000229342	0	0
KIF12	113220	broad.mit.edu	37	9	116857517	116857517	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr9:116857517C>T	ENST00000374118.3	-	7	814	c.577G>A	c.(577-579)Gga>Aga	p.G193R	KIF12_ENST00000473174.1_5'UTR	NM_138424.1	NP_612433.1	Q96FN5	KIF12_HUMAN	kinesin family member 12	326	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	17						CCGCGCCCTCCCAGTGAGTCT	0.642000													31	13					0	0	0.00111076	0	0
SMARCA2	6595	broad.mit.edu	37	9	2039779	2039779	+	Silent	SNP	G	G	A	rs113070757	byFrequency	TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr9:2039779G>A	ENST00000382203.1	+	4	878	c.669G>A	c.(667-669)caG>caA	p.Q223Q	SMARCA2_ENST00000349721.2_Silent_p.Q223Q|SMARCA2_ENST00000357248.2_Silent_p.Q223Q|SMARCA2_ENST00000491574.1_3'UTR|SMARCA2_ENST00000382194.1_Silent_p.Q223Q			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	223	Poly-Gln.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		agcagcaacagcagcagcagc	0.642000													3	13					0	0	6.4e-05	0	0
PDIA3	2923	broad.mit.edu	37	15	44053692	44053692	+	Silent	SNP	T	T	C			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr15:44053692T>C	ENST00000300289.5	+	4	583	c.435T>C	c.(433-435)ttT>ttC	p.F145F	PDIA3_ENST00000538521.1_Silent_p.F125F	NM_005313.4	NP_005304.3	P30101	PDIA3_HUMAN	protein disulfide isomerase family A, member 3	145					cell redox homeostasis|glycerol ether metabolic process|post-translational protein modification|protein folding|protein import into nucleus|protein N-linked glycosylation via asparagine|protein retention in ER lumen|signal transduction	endoplasmic reticulum lumen|melanosome	cysteine-type endopeptidase activity|electron carrier activity|phospholipase C activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(9)|ovary(2)|skin(1)	17		all_cancers(109;2.61e-15)|all_epithelial(112;1.12e-12)|Lung NSC(122;2.17e-08)|all_lung(180;2.45e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.48e-07)		AGGAAGAATTTAAGAAATTCA	0.393000													19	65					0	0	0.000175454	0	0
MED12L	116931	broad.mit.edu	37	3	151075068	151075068	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr3:151075068A>C	ENST00000474524.1	+	18	2662	c.2624A>C	c.(2623-2625)tAt>tCt	p.Y875S	P2RY12_ENST00000302632.3_Intron|MED12L_ENST00000491549.1_3'UTR|MED12L_ENST00000273432.4_Missense_Mutation_p.Y735S	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	875					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCAGGAAGTTATACAACAGGA	0.448000													11	41					0	0	0.000978159	0	0
ULK4	54986	broad.mit.edu	37	3	41957541	41957541	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr3:41957541G>A	ENST00000301831.4	-	8	1193	c.731C>T	c.(730-732)tCt>tTt	p.S244F	ULK4_ENST00000420927.1_Missense_Mutation_p.S244F	NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4	244	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		AGGACGAGAAGAATCTATAAA	0.274000													35	62					0	0	0.000814825	0	0
GIMAP8	155038	broad.mit.edu	37	7	150164156	150164156	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr7:150164156G>A	ENST00000307271.3	+	2	944	c.370G>A	c.(370-372)Gaa>Aaa	p.E124K		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	124						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		GTTTGGAGCTGAAGCCAGGAG	0.478000													23	30					0	0	0.000295444	0	0
DNAH1	25981	broad.mit.edu	37	3	52433701	52433701	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr3:52433701G>A	ENST00000420323.2	+	77	12843	c.12582G>A	c.(12580-12582)gaG>gaA	p.E4194E		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	4259					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TGTACACAGAGATGGCCGTTA	0.552000													28	48					0	0	0.000878237	0	0
IGLV3-21	28796	broad.mit.edu	37	22	23055665	23055665	+	RNA	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr22:23055665G>A	ENST00000390308.2	+	0	579																											TCAGGTGTGGGATAGTAGTAG	0.587000													9	26					0	0	0.000978159	0	0
IGFN1	91156	broad.mit.edu	37	1	201196074	201196074	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:201196074G>A	ENST00000335211.4	+	23	10981	c.10851G>A	c.(10849-10851)ctG>ctA	p.L3617L	IGFN1_ENST00000295591.8_3'UTR	NM_001164586.1	NP_001158058.1			immunoglobulin-like and fibronectin type III domain containing 1											autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						CCCGGTTCCTGGTGGGCCTGC	0.662000													58	28					0	0	0.000781405	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204412635	204412635	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:204412635C>T	ENST00000367187.3	-	20	3514	c.2958G>A	c.(2956-2958)ctG>ctA	p.L986L	PIK3C2B_ENST00000424712.2_Silent_p.L958L	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	986					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			ACTCTTCTCTCAGCCCCTTGC	0.592000													71	55					0	0	0.000781405	0	0
ZFP90	146198	broad.mit.edu	37	16	68597607	68597607	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr16:68597607G>A	ENST00000570495.1	+	5	1209	c.917G>A	c.(916-918)gGa>gAa	p.G306E	ZFP90_ENST00000563169.2_Missense_Mutation_p.G306E|ZFP90_ENST00000398253.2_Missense_Mutation_p.G306E|RP11-615I2.7_ENST00000571720.1_RNA			Q8TF47	ZFP90_HUMAN	ZFP90 zinc finger protein	306					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		GCTCATACCGGAGAGAAACCC	0.493000													15	20					0	0	0.000132079	0	0
TRBV7-6	28592	broad.mit.edu	37	7	142139544	142139544	+	RNA	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr7:142139544G>A	ENST00000390374.3	-	0	125																											CTTTGTACCTGGGAGACTGGG	0.493000													13	36					0	0	0.000219431	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369339.2_Intron|NBPF10_ENST00000369338.1_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													4	42					0	0	0.00024832	0	0
MED23	9439	broad.mit.edu	37	6	131912565	131912565	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr6:131912565C>T	ENST00000403834.3	-	26	3765	c.3592G>A	c.(3592-3594)Gat>Aat	p.D1198N	MED23_ENST00000368060.3_Missense_Mutation_p.D1192N|MED23_ENST00000354577.4_Missense_Mutation_p.D1198N|MED23_ENST00000479213.1_5'UTR|MED23_ENST00000545957.1_Missense_Mutation_p.D833N|MED23_ENST00000368068.3_Missense_Mutation_p.D1192N|MED23_ENST00000368058.1_Missense_Mutation_p.D1198N			Q9ULK4	MED23_HUMAN	mediator complex subunit 23	1192					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity	p.D1198Y(1)|p.D1192Y(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(12)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	44	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		GCAGTGAAATCAAAGAGGCGG	0.473000													10	39					0	0	0.000673444	0	0
DENND3	22898	broad.mit.edu	37	8	142146806	142146806	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr8:142146806G>A	ENST00000519811.1	+	2	371	c.301G>A	c.(301-303)Ggg>Agg	p.G101R	DENND3_ENST00000262585.2_Missense_Mutation_p.G21R|DENND3_ENST00000424248.1_Missense_Mutation_p.G21R|DENND3_ENST00000518347.1_Missense_Mutation_p.G101R			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	21										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			GGGCCTCCCGGGGCCCCCCAG	0.652000													4	9					0	0	8.12818e-05	0	0
DCLK3	85443	broad.mit.edu	37	3	36779958	36779958	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr3:36779958C>T	ENST00000416516.2	-	2	683	c.193G>A	c.(193-195)Gaa>Aaa	p.E65K		NM_033403.1	NP_208382.1	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	65						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	48						CCTGCAACTTCGCTGCAGCTC	0.612000													63	60					0	0	0.000781405	0	0
LINC00610	399879	broad.mit.edu	37	11	36293339	36293339	+	RNA	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr11:36293339G>A	ENST00000355500.1	-	0	232																											GGTGTGGCAGGAAGATGGACC	0.532000													41	68					0	0	0.000781405	0	0
TWIST1	7291	broad.mit.edu	37	7	19156395	19156395	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr7:19156395T>C	ENST00000242261.5	-	1	900	c.550A>G	c.(550-552)Agc>Ggc	p.S184G		NM_000474.3	NP_000465.1	Q15672	TWST1_HUMAN	twist family bHLH transcription factor 1	184	Sufficient for transactivation activity (By similarity).				aortic valve morphogenesis|cellular response to hypoxia|embryonic camera-type eye formation|embryonic cranial skeleton morphogenesis|eyelid development in camera-type eye|muscle organ development|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of histone phosphorylation|negative regulation of osteoblast differentiation|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of transcription from RNA polymerase II promoter|positive regulation of angiogenesis|positive regulation of cell motility|positive regulation of epithelial to mesenchymal transition|positive regulation of fatty acid beta-oxidation|positive regulation of monocyte chemotactic protein-1 production|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of tumor necrosis factor production|regulation of bone mineralization	nucleus	bHLH transcription factor binding|E-box binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			lung(2)|upper_aerodigestive_tract(1)	3						AAGGCGTAGCTGAGCCGCTCG	0.657000													6	15					0	0	8.12818e-05	0	0
ARMC4	55130	broad.mit.edu	37	10	28101489	28101489	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr10:28101489G>A	ENST00000545014.1	-	14	2130	c.1784C>T	c.(1783-1785)cCa>cTa	p.P595L	ARMC4_ENST00000537576.1_Intron|ARMC4_ENST00000305242.5_Silent_p.S1029S			Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	0							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						TGCGGATATTGGATATACAAC	0.458000													16	88					0	0	0.000566183	0	0
ZPLD1	131368	broad.mit.edu	37	3	102176642	102176642	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr3:102176642C>T	ENST00000306176.1	+	5	675	c.575C>T	c.(574-576)tCt>tTt	p.S192F	ZPLD1_ENST00000491959.1_Missense_Mutation_p.S176F|ZPLD1_ENST00000466937.1_Missense_Mutation_p.S176F	NM_175056.1	NP_778226.1	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	176	ZP.					integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(18)|ovary(2)|skin(3)	35						GCGGCTATTTCTGTGAGAGAG	0.373000													58	74					0	0	0.000781405	0	0
SLC25A42	284439	broad.mit.edu	37	19	19206977	19206977	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr19:19206977A>C	ENST00000318596.7	+	2	195	c.44A>C	c.(43-45)gAt>gCt	p.D15A		NM_178526.4	NP_848621.2	Q86VD7	S2542_HUMAN	solute carrier family 25, member 42	15					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			cervix(1)|large_intestine(2)|lung(3)	6			OV - Ovarian serous cystadenocarcinoma(5;5.4e-06)|Epithelial(12;0.000497)			TTGCATGAGGATGCTGAGGCT	0.642000													9	13					0	0	0.000978159	0	0
LRCH2	57631	broad.mit.edu	37	X	114357343	114357343	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chrX:114357343G>A	ENST00000317135.8	-	19	2110	c.2080C>T	c.(2080-2082)Cat>Tat	p.H694Y	LRCH2_ENST00000538422.1_Missense_Mutation_p.H677Y	NM_020871.3	NP_065922.3	Q5VUJ6	LRCH2_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 2	694	CH.									breast(1)|endometrium(4)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	19						GATGGTACATGAATACTAGCA	0.358000													26	6					0	0	0.000184323	0	0
NUP37	79023	broad.mit.edu	37	12	102468181	102468181	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr12:102468181C>G	ENST00000552283.1	-	10	1071	c.932G>C	c.(931-933)tGt>tCt	p.C311S	RP11-554E23.4_ENST00000552707.1_RNA|NUP37_ENST00000251074.1_Missense_Mutation_p.C311S			Q8NFH4	NUP37_HUMAN	nucleoporin 37kDa	311					carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			endometrium(3)|large_intestine(3)|lung(10)|ovary(1)	17						TCCAATTACACACAGAGGGAG	0.393000													3	19					0	0	6.4e-05	0	0
SDK2	54549	broad.mit.edu	37	17	71386490	71386490	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr17:71386490C>T	ENST00000392650.3	-	29	4128	c.4128G>A	c.(4126-4128)acG>acA	p.T1376T	SDK2_ENST00000388726.3_Silent_p.T1376T	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	1376	Fibronectin type-III 8.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						GGGTCTGGGCCGTGATGCGGA	0.682000													8	11					0	0	0.000157383	0	0
CCDC71	64925	broad.mit.edu	37	3	49200991	49200991	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr3:49200991C>T	ENST00000321895.6	-	2	757	c.651G>A	c.(649-651)ggG>ggA	p.G217G		NM_022903.3	NP_075054.3	Q8IV32	CCD71_HUMAN	coiled-coil domain containing 71	217										endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)	10				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CCGGACCCTTCCCTGAACTTT	0.592000													44	63					0	0	0.000781405	0	0
C2orf78	388960	broad.mit.edu	37	2	74041260	74041260	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:74041260G>A	ENST00000409561.1	+	2	875	c.754G>A	c.(754-756)Gag>Aag	p.E252K		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	252										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						GGTGCTGAAGGAGGTTCAGCC	0.483000													16	93					0	0	0.000308642	0	0
SLC24A4	123041	broad.mit.edu	37	14	92911661	92911661	+	Splice_Site	SNP	T	T	C			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr14:92911661T>C	ENST00000532405.1	+	8	884	c.657_splice	c.e8-1	p.F220_splice	SLC24A4_ENST00000298877.1_Splice_Site_p.F203_splice|SLC24A4_ENST00000351924.5_Splice_Site_p.F203_splice|SLC24A4_ENST00000393265.2_Splice_Site_p.F156_splice|SLC24A4_ENST00000531433.1_Splice_Site_p.F220_splice			Q8NFF2	NCKX4_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	220						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(20)|ovary(2)|skin(1)	36		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		TGCCTTACAGTTCATATATGA	0.388000													35	96					0	0	0.000319135	0	0
ZNF213	7760	broad.mit.edu	37	16	3187371	3187371	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr16:3187371G>A	ENST00000396878.3	+	2	565	c.90G>A	c.(88-90)caG>caA	p.Q30Q	ZNF213_ENST00000574902.1_Silent_p.Q30Q|ZNF213_ENST00000576416.1_Silent_p.Q30Q	NM_001134655.1|NM_004220.2	NP_001128127.1|NP_004211.1	O14771	ZN213_HUMAN	zinc finger protein 213	30					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)	16						CCTGGGAACAGGAATCTGCCC	0.617000													31	33					0	0	0.000227799	0	0
POLR1B	84172	broad.mit.edu	37	2	113333151	113333151	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:113333151C>G	ENST00000263331.5	+	15	3833	c.3253C>G	c.(3253-3255)Ccc>Gcc	p.P1085A	POLR1B_ENST00000541869.1_Missense_Mutation_p.P1123A|POLR1B_ENST00000409894.3_Missense_Mutation_p.P902A|POLR1B_ENST00000417433.2_Missense_Mutation_p.P1029A|POLR1B_ENST00000537335.1_Missense_Mutation_p.P874A	NM_019014.4	NP_061887.2	Q9H9Y6	RPA2_HUMAN	polymerase (RNA) I polypeptide B, 128kDa	1085					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(3)|endometrium(9)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42						GGAGAAGCCACCCCCTTCTTG	0.483000													27	27					0	0	0.00106085	0	0
ZNF776	284309	broad.mit.edu	37	19	58265665	58265665	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr19:58265665C>T	ENST00000317178.5	+	3	1430	c.1167C>T	c.(1165-1167)tcC>tcT	p.S389S	ZNF776_ENST00000489376.1_3'UTR	NM_173632.3	NP_775903.3			zinc finger protein 776											cervix(1)|endometrium(2)|kidney(13)|large_intestine(3)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	31		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0256)		GGAGCAACTCCCACCTAAAGG	0.443000													28	17					0	0	0.00106085	0	0
OR10A7	121364	broad.mit.edu	37	12	55615394	55615394	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr12:55615394G>A	ENST00000326258.1	+	1	586	c.586G>A	c.(586-588)Gaa>Aaa	p.E196K		NM_001005280.1	NP_001005280.1	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A, member 7	196					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|lung(11)|ovary(4)|prostate(2)|skin(3)	24						AACCATGTATGAAATGCAAGC	0.443000													15	22					0	0	0.000308642	0	0
C1orf173	127254	broad.mit.edu	37	1	75037720	75037720	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:75037720C>T	ENST00000326665.5	-	14	3892	c.3674G>A	c.(3673-3675)gGa>gAa	p.G1225E	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1225	Glu-rich.							p.G1225E(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						CTGCACCTTTCCTGCTGGCTC	0.627000													13	50					0	0	0.000151284	0	0
EMILIN2	84034	broad.mit.edu	37	18	2892139	2892139	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr18:2892139G>A	ENST00000254528.3	+	4	2173	c.2014G>A	c.(2014-2016)Gag>Aag	p.E672K		NM_032048.2	NP_114437.2	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2	672					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(4)	48				READ - Rectum adenocarcinoma(2;0.1)		TCAGCTGGAGGAGAGGTGGCA	0.612000													20	56					0	0	0.000175454	0	0
PGA5	5222	broad.mit.edu	37	11	61017253	61017253	+	Missense_Mutation	SNP	G	G	A	rs139795742		TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr11:61017253G>A	ENST00000312403.5	+	7	1071	c.886G>A	c.(886-888)Gac>Aac	p.D296N	PGA4_ENST00000422676.2_Missense_Mutation_p.D296N|PGA5_ENST00000541528.1_Missense_Mutation_p.D36N|PGA5_ENST00000451616.2_Missense_Mutation_p.D142N	NM_014224.2	NP_055039.1	P00790	PEPA_HUMAN	pepsinogen 5, group I (pepsinogen A)	296					digestion|proteolysis	extracellular region	aspartic-type endopeptidase activity			large_intestine(1)|skin(1)	2						CATCCAGAGCGACATCGGAGC	0.612000													51	128					0	0	0.000781405	0	0
ABL1	25	broad.mit.edu	37	9	133747600	133747600	+	Splice_Site	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr9:133747600G>A	ENST00000318560.5	+	5	1288	c.907_splice	c.e5+1	p.G303_splice		NM_005157.4	NP_005148.2	P00519	ABL1_HUMAN	c-abl oncogene 1, non-receptor tyrosine kinase	303	Protein kinase.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(3)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1149)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	1195		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	GCAGCTCCTTGGTGAGTAAGC	0.572000			"""T, Mis"""	"""BCR, ETV6, NUP214"""	"""CML, ALL, T-ALL"""								6	7					0	0	8.12818e-05	0	0
ZFYVE1	53349	broad.mit.edu	37	14	73490749	73490749	+	Missense_Mutation	SNP	T	T	G			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr14:73490749T>G	ENST00000556143.1	-	2	1188	c.468A>C	c.(466-468)gaA>gaC	p.E156D	ZFYVE1_ENST00000318876.5_Missense_Mutation_p.E156D|ZFYVE1_ENST00000553891.1_Missense_Mutation_p.E156D	NM_021260.2	NP_067083.1	Q9HBF4	ZFYV1_HUMAN	zinc finger, FYVE domain containing 1	156						endoplasmic reticulum|Golgi stack|perinuclear region of cytoplasm	1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(17)|ovary(1)|prostate(2)|skin(1)	35		all_lung(585;1.33e-09)		OV - Ovarian serous cystadenocarcinoma(108;1.6e-46)|BRCA - Breast invasive adenocarcinoma(234;0.00349)		TTTCTTCATTTTCGTCTACTA	0.453000													5	226					0	0	0.000602214	0	0
ANO2	57101	broad.mit.edu	37	12	5687593	5687593	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr12:5687593G>A	ENST00000356134.5	-	23	2399	c.2328C>T	c.(2326-2328)ctC>ctT	p.L776L	ANO2_ENST00000546188.1_Silent_p.L776L|ANO2_ENST00000327087.8_Silent_p.L775L	NM_001278596.1|NM_001278597.1	NP_001265525.1|NP_001265526.1	Q9NQ90	ANO2_HUMAN	anoctamin 2	780						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						TCTTTGCATCGAGCCGCACTT	0.542000													21	36					0	0	0.000375601	0	0
PCDHGA11	56105	broad.mit.edu	37	5	140801022	140801022	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr5:140801022C>T	ENST00000398587.2	+	1	261	c.228C>T	c.(226-228)ttC>ttT	p.F76F	PCDHGA8_ENST00000398604.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA11_ENST00000518882.1_Silent_p.F76F|PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018914.2|NM_032092.1	NP_061737.1|NP_114481.1														breast(3)|endometrium(8)|kidney(3)|large_intestine(9)|lung(22)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACAGCTTTTCGCTGTGAATC	0.587000													34	17					0	0	0.000814825	0	0
ASCC2	84164	broad.mit.edu	37	22	30202248	30202248	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr22:30202248C>T	ENST00000397771.2	-	13	1294	c.1117G>A	c.(1117-1119)Gtg>Atg	p.V373M	ASCC2_ENST00000542393.1_Missense_Mutation_p.V297M|ASCC2_ENST00000478812.1_5'UTR|ASCC2_ENST00000307790.3_Missense_Mutation_p.V373M			Q9H1I8	ASCC2_HUMAN	activating signal cointegrator 1 complex subunit 2	373					regulation of transcription, DNA-dependent|transcription, DNA-dependent					endometrium(3)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(5;0.000103)|Epithelial(10;0.0169)|all cancers(5;0.0259)			TCTTCGGCCACGGGGAAGAGT	0.582000													17	132					0	0	0.000175454	0	0
NANOGP1	404635	broad.mit.edu	37	12	8048124	8048124	+	RNA	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr12:8048124C>T	ENST00000607111.1	+	0	52																				kidney(1)|lung(4)|prostate(1)	6						AGCCATGATTCTTCCACCAGT	0.438000													36	63					0	0	0.000509022	0	0
ACSL6	23305	broad.mit.edu	37	5	131309057	131309057	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr5:131309057A>G	ENST00000379264.2	-	12	1213	c.1105T>C	c.(1105-1107)Ttc>Ctc	p.F369L	ACSL6_ENST00000296869.4_Missense_Mutation_p.F369L|ACSL6_ENST00000379240.1_Missense_Mutation_p.F344L|ACSL6_ENST00000379249.3_Missense_Mutation_p.F344L|ACSL6_ENST00000544770.1_Missense_Mutation_p.F253L|ACSL6_ENST00000431707.1_Missense_Mutation_p.F324L|ACSL6_ENST00000543479.1_Missense_Mutation_p.F344L|ACSL6_ENST00000357096.1_Intron|ACSL6_ENST00000379246.1_Missense_Mutation_p.F355L|ACSL6_ENST00000379255.1_Intron|ACSL6_ENST00000379244.1_Missense_Mutation_p.F344L|ACSL6_ENST00000379272.2_Missense_Mutation_p.F359L	NM_001009185.2	NP_001009185.1	Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6	344					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	35		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCTCCCTGGAAGAAGCCAACA	0.547000													11	24					0	0	0.000151284	0	0
C16orf58	64755	broad.mit.edu	37	16	31503655	31503655	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr16:31503655A>G	ENST00000327237.2	-	11	1133	c.1094T>C	c.(1093-1095)gTa>gCa	p.V365A	C16orf58_ENST00000570164.1_Missense_Mutation_p.V363A|C16orf58_ENST00000567994.1_Missense_Mutation_p.V320A			Q96GQ5	CP058_HUMAN	chromosome 16 open reading frame 58	365						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)	14						AACTACCTGTACCTGGTCTGG	0.607000													15	12					0	0	0.000219431	0	0
IQCH	64799	broad.mit.edu	37	15	67681217	67681217	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr15:67681217A>C	ENST00000335894.4	+	12	1571	c.1505A>C	c.(1504-1506)gAg>gCg	p.E502A	IQCH_ENST00000358767.3_Missense_Mutation_p.E329A|IQCH_ENST00000546225.1_Missense_Mutation_p.E250A|IQCH_ENST00000360277.4_Missense_Mutation_p.E254A	NM_001031715.2	NP_001026885.1	Q86VS3	IQCH_HUMAN	IQ motif containing H	502										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		ATGAATGACGAGTTAGTGCTG	0.393000													26	53					0	0	0.000586117	0	0
DENND3	22898	broad.mit.edu	37	8	142146807	142146807	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr8:142146807G>A	ENST00000519811.1	+	2	372	c.302G>A	c.(301-303)gGg>gAg	p.G101E	DENND3_ENST00000262585.2_Missense_Mutation_p.G21E|DENND3_ENST00000424248.1_Missense_Mutation_p.G21E|DENND3_ENST00000518347.1_Missense_Mutation_p.G101E			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	21										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			GGCCTCCCGGGGCCCCCCAGA	0.657000													4	10					0	0	8.12818e-05	0	0
VIMP	55829	broad.mit.edu	37	15	101814677	101814677	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr15:101814677G>A	ENST00000398226.3	-	5	464	c.432C>T	c.(430-432)tcC>tcT	p.S144S	VIMP_ENST00000526049.1_Silent_p.S144S|VIMP_ENST00000537379.1_Silent_p.S144S|VIMP_ENST00000531964.1_Silent_p.S121S					VCP-interacting membrane protein																		CAGATGAAGTGGAAGGCCCAG	0.458000													8	6					0	0	0.000274275	0	0
ARNT2	9915	broad.mit.edu	37	15	80873662	80873662	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr15:80873662C>T	ENST00000533983.1	+	18	2141	c.1802C>T	c.(1801-1803)tCc>tTc	p.S601F	ARNT2_ENST00000303329.4_Missense_Mutation_p.S612F|ARNT2_ENST00000527771.1_Missense_Mutation_p.S601F			Q9HBZ2	ARNT2_HUMAN	aryl-hydrocarbon receptor nuclear translocator 2	612					central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|pancreas(2)|prostate(2)|skin(1)	35			BRCA - Breast invasive adenocarcinoma(143;0.134)			GACCCCTCTTCCTACAGCCCC	0.572000													38	27					0	0	0.000228196	0	0
CD2	914	broad.mit.edu	37	1	117297114	117297114	+	Translation_Start_Site	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:117297114G>A	ENST00000369478.3	+	0	108				CD2_ENST00000369477.1_De_novo_Start_InFrame	NM_001767.3	NP_001758.2	P06729	CD2_HUMAN	CD2 molecule						blood coagulation|cell surface receptor linked signaling pathway|cell-cell adhesion|induction of apoptosis|leukocyte migration|membrane raft polarization|natural killer cell activation|positive regulation of myeloid dendritic cell activation|regulation of T cell differentiation|T cell activation	integral to plasma membrane	receptor activity			NS(1)|breast(2)|large_intestine(3)|liver(1)|lung(8)|skin(2)|stomach(1)	18	Lung SC(450;0.225)	all_cancers(81;3.15e-06)|Acute lymphoblastic leukemia(138;1.7e-08)|all_epithelial(167;8.38e-07)|all_lung(203;3.37e-06)|Lung NSC(69;2.31e-05)		Epithelial(280;6.71e-26)|OV - Ovarian serous cystadenocarcinoma(397;4.74e-24)|all cancers(265;1.93e-22)|Lung(183;0.0543)|Kidney(133;0.0813)|Colorectal(144;0.174)|KIRC - Kidney renal clear cell carcinoma(1967;0.176)|LUSC - Lung squamous cell carcinoma(189;0.189)|BRCA - Breast invasive adenocarcinoma(282;0.201)	Alefacept(DB00092)	CAACCCCTAAGATGAGCTTTC	0.453000													9	39					0	0	0.000673444	0	0
TRAV2	28691	broad.mit.edu	37	14	22180877	22180877	+	RNA	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr14:22180877C>T	ENST00000390424.2	+	0	159																											TGTAATCACTCTGTGTCCAAT	0.468000													109	57					0	0	0.000781405	0	0
BCL2L12	83596	broad.mit.edu	37	19	50173529	50173529	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr19:50173529C>T	ENST00000246785.3	+	6	996	c.738C>T	c.(736-738)ttC>ttT	p.F246F	BCL2L12_ENST00000246784.3_3'UTR|BCL2L12_ENST00000441864.2_Silent_p.F245F	NM_001040668.1|NM_138639.1	NP_001035758.1|NP_619580.1	Q9HB09	B2L12_HUMAN	BCL2-like 12 (proline rich)	246					apoptosis					central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|skin(1)	8		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.000681)|GBM - Glioblastoma multiforme(134;0.0214)		CCGACTCTTTCGCCCGCCTGG	0.731000													5	16					0	0	8.12818e-05	0	0
BTN1A1	696	broad.mit.edu	37	6	26509343	26509343	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr6:26509343G>T	ENST00000244513.6	+	7	1588	c.1522G>T	c.(1522-1524)Gat>Tat	p.D508Y		NM_001732.2	NP_001723.2	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1	508						extracellular region|integral to plasma membrane	receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|skin(1)|soft_tissue(1)|urinary_tract(1)	26						TGCCCCTAGGGATGCAGACAC	0.522000													10	94					0.00010058	0.00130971	0.00010058	1	0
DDX11	1663	broad.mit.edu	37	12	31249911	31249911	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr12:31249911C>T	ENST00000407793.2	+	17	2000	c.1749C>T	c.(1747-1749)atC>atT	p.I583I	DDX11_ENST00000251758.5_3'UTR|DDX11_ENST00000228264.6_Silent_p.I557I|DDX11_ENST00000545668.1_Silent_p.I583I|DDX11_ENST00000542838.1_Silent_p.I583I|DDX11_ENST00000539673.1_3'UTR|DDX11_ENST00000350437.4_Silent_p.I583I	NM_030653.3|NM_152438.1	NP_085911.2|NP_689651.1	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11	583					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(11)|large_intestine(5)|lung(23)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	57	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					GCAGGGTCATCCTGAGCCGCC	0.597000										Multiple Myeloma(12;0.14)			9	20					0	0	0.000274275	0	0
PDK3	5165	broad.mit.edu	37	X	24521592	24521592	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chrX:24521592A>G	ENST00000441463.2	+	4	469	c.469A>G	c.(469-471)Aac>Gac	p.N157D	PDK3_ENST00000379162.4_Missense_Mutation_p.N157D	NM_001142386.2	NP_001135858.1	Q15120	PDK3_HUMAN	pyruvate dehydrogenase kinase, isozyme 3	157	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|protein binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			NS(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						GTTTTATACCAACCGCATCTC	0.383000													22	11					0	0	0.000295444	0	0
CYTH1	9267	broad.mit.edu	37	17	76676303	76676303	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr17:76676303C>T	ENST00000589297.1	-	13	1602	c.910G>A	c.(910-912)Gag>Aag	p.E304K	CYTH1_ENST00000586175.1_5'UTR|CYTH1_ENST00000591455.1_Missense_Mutation_p.E362K|CYTH1_ENST00000585509.1_Missense_Mutation_p.E304K|CYTH1_ENST00000446868.3_Missense_Mutation_p.E363K|CYTH1_ENST00000589296.1_Intron|CYTH1_ENST00000361101.4_Missense_Mutation_p.E363K			Q15438	CYH1_HUMAN	cytohesin 1	363	PH.				regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	19						TCCTTCTCCTCGGGCGTCGGA	0.562000													19	40					0	0	0.000295444	0	0
POU1F1	5449	broad.mit.edu	37	3	87309110	87309110	+	Missense_Mutation	SNP	T	T	G			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr3:87309110T>G	ENST00000350375.2	-	6	934	c.810A>C	c.(808-810)aaA>aaC	p.K270N	POU1F1_ENST00000560656.1_3'UTR|POU1F1_ENST00000344265.3_Missense_Mutation_p.K296N	NM_000306.2	NP_000297.1	P28069	PIT1_HUMAN	POU class 1 homeobox 1	270					negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(5)|liver(1)|lung(7)|prostate(2)|skin(2)	18	all_cancers(8;0.104)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00229)|Lung(72;0.00677)		TTTTCACCCGTTTTTCTCTCT	0.373000													16	30					0	0	0.000958276	0	0
TAF1L	138474	broad.mit.edu	37	9	32633448	32633448	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr9:32633448C>T	ENST00000242310.4	-	1	2219	c.2130G>A	c.(2128-2130)atG>atA	p.M710I		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	710					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CAACCTGCATCATTAAGGGTC	0.418000													46	52					0	0	0.000781405	0	0
SORCS3	22986	broad.mit.edu	37	10	106918692	106918692	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr10:106918692C>T	ENST00000369701.3	+	11	1899	c.1672C>T	c.(1672-1674)Cca>Tca	p.P558S		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	558						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CTCTGAAAATCCATATTCCTC	0.448000													10	42					0	0	0.000151284	0	0
LOC101927958	101927958	broad.mit.edu	37	2	239141444	239141444	+	RNA	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:239141444G>A	ENST00000456601.1	+	0	906																											ACATGCAGAGGGAGCCAAACC	0.532000													7	11					0	0	8.12818e-05	0	0
SMC1B	27127	broad.mit.edu	37	22	45785651	45785651	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr22:45785651G>A	ENST00000357450.4	-	10	1671	c.1672C>T	c.(1672-1674)Cga>Tga	p.R558*	SMC1B_ENST00000404354.3_Nonsense_Mutation_p.R558*	NM_148674.3	NP_683515.3	Q8NDV3	SMC1B_HUMAN	structural maintenance of chromosomes 1B	558	Flexible hinge.				chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		TTCAGAAATCGAATACAATCT	0.388000													126	76					0	0	0.000781405	0	0
HEG1	57493	broad.mit.edu	37	3	124689609	124689609	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr3:124689609C>T	ENST00000311127.4	-	17	4100	c.4033G>A	c.(4033-4035)Gga>Aga	p.G1345R		NM_020733.1	NP_065784.1	Q9ULI3	HEG1_HUMAN	heart development protein with EGF-like domains 1	1345						extracellular region|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(24)|ovary(2)|urinary_tract(4)	47						GGGTAGAGTCCGTTTCGTTCA	0.438000													4	7					0	0	0.000602214	0	0
MYO18B	84700	broad.mit.edu	37	22	26222395	26222395	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr22:26222395G>A	ENST00000335473.7	+	14	2965	c.2715G>A	c.(2713-2715)gtG>gtA	p.V905V	MYO18B_ENST00000536101.1_Silent_p.V905V|MYO18B_ENST00000407587.2_Silent_p.V905V	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	905	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						TGACAGGAGTGGACTGTGTGG	0.562000													42	153					0	0	0.000781405	0	0
ATP13A3	79572	broad.mit.edu	37	3	194146149	194146149	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr3:194146149T>A	ENST00000439040.1	-	30	4026	c.3235A>T	c.(3235-3237)Att>Ttt	p.I1079F	ATP13A3_ENST00000256031.4_Missense_Mutation_p.I1079F			Q9H7F0	AT133_HUMAN	ATPase type 13A3	1079					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	24	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		AAACTGGAAATAAAAAACACT	0.348000													33	33					0	0	0.000339439	0	0
PELI2	57161	broad.mit.edu	37	14	56755313	56755313	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr14:56755313C>T	ENST00000267460.4	+	4	754	c.468C>T	c.(466-468)ttC>ttT	p.F156F		NM_021255.2	NP_067078.1	Q9HAT8	PELI2_HUMAN	pellino E3 ubiquitin protein ligase family member 2	156					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of protein phosphorylation|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	protein binding			kidney(6)|large_intestine(3)|lung(11)|ovary(1)|skin(1)	22						CACGGATATTCGCCGCCGGAT	0.458000													5	21					0	0	0.000602214	0	0
IGLL5	100423062	broad.mit.edu	37	22	23237605	23237605	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr22:23237605G>A	ENST00000532223.1	+	3	653	c.379G>A	c.(379-381)Gag>Aag	p.E127K	IGLL5_ENST00000531372.1_3'UTR|IGLC1_ENST00000390321.2_RNA|IGLL5_ENST00000526893.1_Missense_Mutation_p.E126K			B9A064	IGLL5_HUMAN	immunoglobulin lambda-like polypeptide 5	126	C region (By similarity to lambda light- chain).|Ig-like C1-type.					extracellular region				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|urinary_tract(1)	7						CTCCTCTGAGGAGCTCCAAGC	0.612000													17	36					0	0	0.00074312	0	0
FCN2	2220	broad.mit.edu	37	9	137778365	137778365	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr9:137778365G>A	ENST00000350339.2	+	6	549	c.535G>A	c.(535-537)Gag>Aag	p.E179K	FCN2_ENST00000291744.6_Missense_Mutation_p.E217K	NM_015837.2	NP_056652.1	Q15485	FCN2_HUMAN	ficolin (collagen/fibrinogen domain containing lectin) 2	217	Fibrinogen C-terminal.				complement activation, lectin pathway|opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|calcium-dependent protein binding|receptor binding|sugar binding			breast(2)|central_nervous_system(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	20		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.58e-08)|Epithelial(140;6.41e-08)|all cancers(34;3.96e-07)		CGACGAGGCGGAGAAGTACAA	0.572000													39	13					0	0	0.00111076	0	0
TINF2	26277	broad.mit.edu	37	14	24711504	24711504	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr14:24711504A>T	ENST00000399423.4	-	1	365	c.35T>A	c.(34-36)cTa>cAa	p.L12Q	TINF2_ENST00000559019.1_Missense_Mutation_p.L12Q|TINF2_ENST00000540705.1_Missense_Mutation_p.L12Q|TINF2_ENST00000267415.7_Missense_Mutation_p.L12Q|TINF2_ENST00000558510.1_5'UTR|TINF2_ENST00000538777.1_5'UTR|TINF2_ENST00000558566.1_Missense_Mutation_p.L12Q	NM_012461.2	NP_036593.2	Q9BSI4	TINF2_HUMAN	TERF1 (TRF1)-interacting nuclear factor 2	12					negative regulation of epithelial cell proliferation|negative regulation of protein ADP-ribosylation|negative regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance|protein localization to chromosome, telomeric region|telomere assembly|telomere maintenance via telomere lengthening	nuclear telomere cap complex|nucleoplasm|perinucleolar chromocenter	protein binding|telomeric DNA binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|prostate(1)|urinary_tract(1)	7				GBM - Glioblastoma multiforme(265;0.0185)		GGCGAAGCGTAGAGCTGCGGG	0.687000									Congenital Dyskeratosis;Ataxia Pancytopenia syndrome		OREG0022621	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	33					0	0	0.000157383	0	0
STK31	56164	broad.mit.edu	37	7	23871965	23871965	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr7:23871965G>A	ENST00000354639.3	+	24	3435	c.2971G>A	c.(2971-2973)Gaa>Aaa	p.E991K	STK31_ENST00000428484.1_Missense_Mutation_p.E991K|STK31_ENST00000405627.3_3'UTR|STK31_ENST00000355870.3_Missense_Mutation_p.E1014K|STK31_ENST00000433467.2_Missense_Mutation_p.E991K	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	1014	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						AAGAAATGGTGAAGCCAACTT	0.313000													97	113					0	0	0.000781405	0	0
FAM181A	90050	broad.mit.edu	37	14	94395003	94395003	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr14:94395003G>A	ENST00000267594.5	+	3	865	c.558G>A	c.(556-558)caG>caA	p.Q186Q	FAM181A_ENST00000556222.1_Silent_p.Q124Q|FAM181A_ENST00000557719.1_Silent_p.Q124Q|FAM181A_ENST00000557000.2_Silent_p.Q124Q	NM_001207073.1|NM_001207074.1|NM_138344.4	NP_001194002.1|NP_001194003.1|NP_612353.3	Q8N9Y4	F181A_HUMAN	family with sequence similarity 181, member A	186										cervix(1)|endometrium(2)|large_intestine(8)|lung(4)|prostate(1)|skin(2)	18						AAGCTGCCCAGCCTGGCCAGG	0.632000													20	13					0	0	0.000175454	0	0
GRN	2896	broad.mit.edu	37	17	42429791	42429791	+	Missense_Mutation	SNP	T	T	G	rs63751698		TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr17:42429791T>G	ENST00000053867.3	+	12	1558	c.1496T>G	c.(1495-1497)gTg>gGg	p.V499G	GRN_ENST00000589265.1_Missense_Mutation_p.V342G	NM_002087.2	NP_002078.1	P28799	GRN_HUMAN	granulin	499					signal transduction	extracellular space	cytokine activity|growth factor activity			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		GAGAAGGAAGTGGTCTCTGCC	0.632000													7	49					0	0	0.000442599	0	0
CD2	914	broad.mit.edu	37	1	117311185	117311185	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:117311185C>T	ENST00000369478.3	+	5	944	c.836C>T	c.(835-837)tCc>tTc	p.S279F		NM_001767.3	NP_001758.2	P06729	CD2_HUMAN	CD2 molecule	279					blood coagulation|cell surface receptor linked signaling pathway|cell-cell adhesion|induction of apoptosis|leukocyte migration|membrane raft polarization|natural killer cell activation|positive regulation of myeloid dendritic cell activation|regulation of T cell differentiation|T cell activation	integral to plasma membrane	receptor activity			NS(1)|breast(2)|large_intestine(3)|liver(1)|lung(8)|skin(2)|stomach(1)	18	Lung SC(450;0.225)	all_cancers(81;3.15e-06)|Acute lymphoblastic leukemia(138;1.7e-08)|all_epithelial(167;8.38e-07)|all_lung(203;3.37e-06)|Lung NSC(69;2.31e-05)		Epithelial(280;6.71e-26)|OV - Ovarian serous cystadenocarcinoma(397;4.74e-24)|all cancers(265;1.93e-22)|Lung(183;0.0543)|Kidney(133;0.0813)|Colorectal(144;0.174)|KIRC - Kidney renal clear cell carcinoma(1967;0.176)|LUSC - Lung squamous cell carcinoma(189;0.189)|BRCA - Breast invasive adenocarcinoma(282;0.201)	Alefacept(DB00092)	CCAGCAACTTCCCAACATCCT	0.582000													19	4					0	0	0.000958276	0	0
SERPINB2	5055	broad.mit.edu	37	18	61570538	61570538	+	Nonstop_Mutation	SNP	A	A	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr18:61570538A>T	ENST00000457692.1	+	9	1580	c.1247A>T	c.(1246-1248)tAa>tTa	p.*416L	SERPINB2_ENST00000299502.4_Nonstop_Mutation_p.*416L	NM_001143818.1	NP_001137290.1	P05120	PAI2_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0					anti-apoptosis|blood coagulation|fibrinolysis|regulation of proteolysis	extracellular space|Golgi apparatus|plasma membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|liver(1)|lung(12)|prostate(2)|skin(2)|stomach(1)	32		Esophageal squamous(42;0.131)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)|Urokinase(DB00013)	TCCTCACCCTAAAACTAAGCG	0.368000													9	4					0	0	0.000978159	0	0
AKAP6	9472	broad.mit.edu	37	14	33292161	33292161	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr14:33292161G>A	ENST00000280979.4	+	13	5312	c.5142G>A	c.(5140-5142)tcG>tcA	p.S1714S	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1714					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TCCCGGAATCGAATGCATCGT	0.468000													42	22					0	0	0.000781405	0	0
PLSCR2	57047	broad.mit.edu	37	3	146166996	146166996	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr3:146166996G>A	ENST00000497985.1	-	8	1300	c.861C>T	c.(859-861)ctC>ctT	p.L287L	PLSCR2_ENST00000336685.2_Silent_p.L214L	NM_001199978.1	NP_001186907.1	Q9NRY7	PLS2_HUMAN	phospholipid scramblase 2	214					phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity			endometrium(2)|large_intestine(5)|lung(7)|stomach(1)	15						GACTTACAATGAGGAAACAGG	0.348000													41	58					0	0	0.000509022	0	0
TMEM17	200728	broad.mit.edu	37	2	62728427	62728427	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:62728427G>A	ENST00000335390.5	-	4	725	c.514C>T	c.(514-516)Cgt>Tgt	p.R172C		NM_198276.2	NP_938017.2	Q86X19	TMM17_HUMAN	transmembrane protein 17	172						integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)	9	Lung NSC(7;0.0274)|all_lung(7;0.0568)		LUSC - Lung squamous cell carcinoma(7;1.31e-05)|Epithelial(17;0.169)			AGGTGGAAACGAACTGCCAAC	0.428000													20	111					0	0	0.000132079	0	0
NPHS1	4868	broad.mit.edu	37	19	36334397	36334397	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr19:36334397C>T	ENST00000378910.5	-	17	2310	c.2311G>A	c.(2311-2313)Ggc>Agc	p.G771S	NPHS1_ENST00000353632.6_Missense_Mutation_p.G771S	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	771	Ig-like C2-type 7.				cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TTGAACATGCCCGGGAGGATG	0.572000													48	47					0	0	0.000781405	0	0
GPR155	151556	broad.mit.edu	37	2	175306874	175306874	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:175306874T>A	ENST00000392552.2	-	14	2385	c.2147A>T	c.(2146-2148)cAt>cTt	p.H716L	GPR155_ENST00000459996.1_5'UTR|GPR155_ENST00000295500.4_Missense_Mutation_p.H716L|GPR155_ENST00000392551.2_Missense_Mutation_p.H716L	NM_001267051.1|NM_152529.6	NP_001253980.1|NP_689742.4	Q7Z3F1	GP155_HUMAN	G protein-coupled receptor 155	716					intracellular signal transduction|transmembrane transport	integral to membrane				breast(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(2)	26						GATGATTAAATGTTTATCTAA	0.269000													10	54					0	0	0.000442599	0	0
RNF112	7732	broad.mit.edu	37	17	19315926	19315926	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr17:19315926G>T	ENST00000461366.1	+	3	426	c.211G>T	c.(211-213)Gac>Tac	p.D71Y	RNF112_ENST00000580109.1_3'UTR|CTB-187M2.2_ENST00000579897.1_RNA	NM_007148.4	NP_009079.2	Q7Z5V9	Q7Z5V9_HUMAN	ring finger protein 112	71							GTP binding|GTPase activity|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|urinary_tract(1)	12						CATCTCGCTGGACTGTGGCCA	0.652000													12	5					2.80697e-09	3.69063e-08	0.000978159	1	0
MUC16	94025	broad.mit.edu	37	19	9083846	9083846	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr19:9083846G>C	ENST00000397910.4	-	1	8172	c.7969C>G	c.(7969-7971)Cca>Gca	p.P2657A		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2657	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAACTTGTTGGCTCAGTGGCA	0.517000													11	26					0	0	0.000151284	0	0
ILF3	3609	broad.mit.edu	37	19	10794134	10794134	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr19:10794134C>T	ENST00000449870.1	+	15	2096	c.1779C>T	c.(1777-1779)ttC>ttT	p.F593F	ILF3_ENST00000590261.1_Silent_p.F589F|ILF3_ENST00000589998.1_Silent_p.F589F|ILF3_ENST00000588657.1_Silent_p.F593F|ILF3_ENST00000592763.1_Silent_p.F593F|ILF3_ENST00000250241.8_Silent_p.F589F|ILF3_ENST00000420083.1_Silent_p.F589F|ILF3_ENST00000318511.3_Silent_p.F589F|ILF3_ENST00000407004.3_Silent_p.F593F	NM_017620.2	NP_060090.2	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3, 90kDa	589					M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			AAAAGCTTTTCCCTGACACCC	0.542000													19	16					0	0	0.00074312	0	0
RP11-344E13.3	0	broad.mit.edu	37	17	20805809	20805809	+	RNA	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr17:20805809C>T	ENST00000577537.1	+	0	993				RP11-344E13.3_ENST00000577860.1_RNA|RP11-344E13.3_ENST00000417232.2_RNA|RP11-344E13.3_ENST00000439794.2_RNA|RP11-344E13.3_ENST00000583962.1_RNA																							TGTTGATTTTCCTGCCCTTCT	0.512000													22	7					0	0	0.000295444	0	0
IDE	3416	broad.mit.edu	37	10	94267332	94267332	+	Splice_Site	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr10:94267332C>T	ENST00000265986.6	-	9	1301	c.1245_splice	c.e9+1	p.K415_splice		NM_004969.3	NP_004960.2	P14735	IDE_HUMAN	insulin-degrading enzyme	415					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|urinary_tract(2)	33					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ACAAAAGTACCTTGCACTCTT	0.313000													172	174					0	0	0.000781405	0	0
ZDBF2	57683	broad.mit.edu	37	2	207174867	207174867	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:207174867G>A	ENST00000374423.3	+	5	6001	c.5615G>A	c.(5614-5616)gGg>gAg	p.G1872E		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1872							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						TCTTCGAAGGGGAAAAAAAAG	0.418000													5	17					0	0	3.59834e-05	0	0
CD300A	11314	broad.mit.edu	37	17	72477958	72477958	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr17:72477958G>A	ENST00000360141.3	+	6	1048	c.760G>A	c.(760-762)Gaa>Aaa	p.E254K	CD300A_ENST00000361933.3_Missense_Mutation_p.E58K|CD300A_ENST00000577511.1_Missense_Mutation_p.E124K|CD300A_ENST00000310828.5_Missense_Mutation_p.E141K|CD300A_ENST00000392625.3_Intron	NM_001256841.1|NM_007261.3	NP_001243770.1|NP_009192.2	Q9UGN4	CLM8_HUMAN	CD300a molecule	254					cell adhesion	integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(4)|urinary_tract(1)	16						GGTGGAGGTGGAATACAGCAC	0.632000													12	10					0	0	0.00010058	0	0
ASNSD1	54529	broad.mit.edu	37	2	190532655	190532655	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:190532655C>T	ENST00000260952.4	+	5	2043	c.1630C>T	c.(1630-1632)Cat>Tat	p.H544Y	ASNSD1_ENST00000607062.1_Missense_Mutation_p.H63Y	NM_019048.2	NP_061921.1	Q9NWL6	ASND1_HUMAN	asparagine synthetase domain containing 1	544	Asparagine synthetase.				asparagine biosynthetic process|glutamine metabolic process		asparagine synthase (glutamine-hydrolyzing) activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(3)	25			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0449)|all cancers(119;0.118)			TATTGGTGATCATGGAAAAGA	0.358000													17	79					0	0	0.000958276	0	0
MED12L	116931	broad.mit.edu	37	3	151075134	151075134	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr3:151075134A>T	ENST00000474524.1	+	18	2728	c.2690A>T	c.(2689-2691)aAt>aTt	p.N897I	P2RY12_ENST00000302632.3_Intron|MED12L_ENST00000273432.4_Missense_Mutation_p.N757I	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	897					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CTAATCTTGAATCCTGATCAG	0.423000													13	55					0	0	0.000308642	0	0
HRNR	388697	broad.mit.edu	37	1	152188349	152188349	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:152188349G>A	ENST00000368801.2	-	3	5831	c.5756C>T	c.(5755-5757)tCa>tTa	p.S1919L	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	1919					keratinization		calcium ion binding|protein binding	p.S1919*(1)		autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTGGAAGATGAACCTGAGCT	0.577000													128	1358					0	0	0.000781405	0	0
AGL	178	broad.mit.edu	37	1	100353540	100353540	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:100353540C>T	ENST00000294724.4	+	21	3166	c.2688C>T	c.(2686-2688)gcC>gcT	p.A896A	AGL_ENST00000361522.4_Silent_p.A879A|AGL_ENST00000361915.3_Silent_p.A896A|AGL_ENST00000361302.3_Silent_p.A880A|AGL_ENST00000370161.2_Silent_p.A880A|AGL_ENST00000370165.3_Silent_p.A896A|AGL_ENST00000370163.3_Silent_p.A896A	NM_000028.2	NP_000019.2	P35573	GDE_HUMAN	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	896					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(9)|lung(35)|ovary(1)|prostate(4)|skin(3)|urinary_tract(1)	69		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		TTAGTCTTGCCTCCAGATTAA	0.353000													17	18					0	0	0.000132079	0	0
CHODL	140578	broad.mit.edu	37	21	19638416	19638416	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr21:19638416G>A	ENST00000338326.3	+	5	1171	c.657G>A	c.(655-657)caG>caA	p.Q219Q	CHODL_ENST00000400135.1_Silent_p.Q219Q|CHODL_ENST00000299295.2_3'UTR|CHODL_ENST00000543733.1_3'UTR|CHODL_ENST00000400127.1_3'UTR|CHODL_ENST00000400131.1_Silent_p.Q219Q|CHODL_ENST00000400128.1_3'UTR			Q9H9P2	CHODL_HUMAN	chondrolectin	0					muscle organ development	integral to membrane|perinuclear region of cytoplasm	sugar binding			kidney(1)|large_intestine(3)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_epithelial(11;0.21)		Epithelial(23;0.000191)|all cancers(11;0.000827)|LUSC - Lung squamous cell carcinoma(23;0.00646)|Lung(58;0.0129)|OV - Ovarian serous cystadenocarcinoma(11;0.017)|COAD - Colon adenocarcinoma(22;0.03)|Colorectal(24;0.0917)		AATGGCATCAGAACAATAGCT	0.348000													11	21					0	0	0.000673444	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110509206	110509206	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr8:110509206G>A	ENST00000378402.5	+	64	10490	c.10386G>A	c.(10384-10386)ggG>ggA	p.G3462G		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3462					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GTTTATATGGGATCTATATGA	0.383000										HNSCC(38;0.096)			50	64					0	0	0.000781405	0	0
COL20A1	57642	broad.mit.edu	37	20	61957455	61957455	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr20:61957455G>A	ENST00000422202.1	+	29	3499	c.3431G>A	c.(3430-3432)aGa>aAa	p.R1144K	COL20A1_ENST00000358894.6_Missense_Mutation_p.R1137K|COL20A1_ENST00000326996.6_Missense_Mutation_p.R1169K|COL20A1_ENST00000435874.1_Missense_Mutation_p.R1144K			Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	1137	Collagen-like 2.				cell adhesion	collagen|extracellular space	structural molecule activity			NS(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(21)|ovary(1)|prostate(3)|urinary_tract(2)	36	all_cancers(38;1.39e-10)					CAGGGAATGAGAGGCCTGGAG	0.657000													14	63					0	0	0.00074312	0	0
KMT2D	8085	broad.mit.edu	37	12	49420215	49420215	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr12:49420215G>A	ENST00000301067.7	-	48	15533	c.15534C>T	c.(15532-15534)ttC>ttT	p.F5178F		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		CCCCCACACGGAACATGTGCA	0.587000													10	24					0	0	0.000978159	0	0
ITGB2	3689	broad.mit.edu	37	21	46323296	46323296	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr21:46323296G>A	ENST00000397850.2	-	6	935	c.483C>T	c.(481-483)acC>acT	p.T161T	ITGB2_ENST00000397852.1_Silent_p.T161T|ITGB2_ENST00000397857.1_Silent_p.T161T|ITGB2_ENST00000302347.5_Silent_p.T161T|ITGB2_ENST00000397854.3_Intron|ITGB2_ENST00000355153.4_Silent_p.T161T			P05107	ITB2_HUMAN	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	161	VWFA.				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(6)|lung(14)|ovary(4)|skin(3)	35				Colorectal(79;0.0669)	Simvastatin(DB00641)	GGCCGGACTCGGTGATCTCGT	0.592000													32	47					0	0	0.000409698	0	0
ISX	91464	broad.mit.edu	37	22	35481636	35481636	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr22:35481636C>T	ENST00000308700.6	+	4	1640	c.688C>T	c.(688-690)Ctt>Ttt	p.L230F	ISX_ENST00000404699.2_Missense_Mutation_p.L230F	NM_001008494.1	NP_001008494.1	Q2M1V0	ISX_HUMAN	intestine-specific homeobox	230						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(12)|ovary(3)|prostate(1)|skin(4)	26						GCTATGCATCCTTCCACCTCC	0.552000													87	49					0	0	0.000781405	0	0
MUC16	94025	broad.mit.edu	37	19	9084638	9084638	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr19:9084638G>A	ENST00000397910.4	-	1	7380	c.7177C>T	c.(7177-7179)Ccc>Tcc	p.P2393S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2393	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATGCTAGTGGGACTGATGGAG	0.463000													13	29					0	0	0.00010058	0	0
RBM26	64062	broad.mit.edu	37	13	79929422	79929422	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr13:79929422T>A	ENST00000438737.2	-	12	2227	c.1787A>T	c.(1786-1788)aAt>aTt	p.N596I	RBM26_ENST00000267229.7_Missense_Mutation_p.N596I|RBM26_ENST00000438724.1_Missense_Mutation_p.N596I			Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	596	RRM 1.				mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(6)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		AATAAAGCGATTGTTTAATAC	0.388000													17	19					0	0	0.000175454	0	0
ZNF862	643641	broad.mit.edu	37	7	149543277	149543277	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr7:149543277C>T	ENST00000223210.4	+	3	419	c.174C>T	c.(172-174)ttC>ttT	p.F58F		NM_001099220.1	NP_001092690.1	O60290	ZN862_HUMAN	zinc finger protein 862	58	KRAB 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|skin(1)	34						TCCGCAAGTTCGGACGAGGGC	0.557000													15	27					0	0	0.00074312	0	0
FBXL4	26235	broad.mit.edu	37	6	99365585	99365585	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr6:99365585G>A	ENST00000369244.2	-	5	951	c.523C>T	c.(523-525)Ctt>Ttt	p.L175F	FBXL4_ENST00000229971.1_Missense_Mutation_p.L175F			Q9UKA2	FBXL4_HUMAN	F-box and leucine-rich repeat protein 4	175					ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex				central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(4)|prostate(3)|skin(2)	18		all_cancers(76;1.56e-06)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00893)|Colorectal(196;0.069)|Lung NSC(302;0.197)		BRCA - Breast invasive adenocarcinoma(108;0.0413)		TCTGACCAAAGAATCTCCCAT	0.408000													10	42					0	0	0.000442599	0	0
PDK2	5164	broad.mit.edu	37	17	48184467	48184467	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr17:48184467G>A	ENST00000503176.1	+	6	796	c.635G>A	c.(634-636)tGt>tAt	p.C212Y	PDK2_ENST00000007708.3_Missense_Mutation_p.C148Y	NM_002611.4	NP_002602.2	Q15119	PDK2_HUMAN	pyruvate dehydrogenase kinase, isozyme 2	212	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|nucleus	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			central_nervous_system(4)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	20						AAGCTCCTGTGTGACAAGTAT	0.567000									Autosomal Dominant Polycystic Kidney Disease				12	74					0	0	0.000308642	0	0
TUBA1B	10376	broad.mit.edu	37	12	49522723	49522723	+	Splice_Site	SNP	T	T	C	rs11546601		TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr12:49522723T>C	ENST00000336023.5	-	4	470		c.e4-2		RP11-386G11.10_ENST00000547387.1_RNA	NM_006082.2	NP_006073.2	P68363	TBA1B_HUMAN	tubulin, alpha 1b						'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(2)|lung(4)	12						CTGGTCAGCCTGTAGGGGAAT	0.423000													12	43					0	0	0.000219431	0	0
OGDHL	55753	broad.mit.edu	37	10	50959932	50959932	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr10:50959932C>T	ENST00000374103.4	-	6	775	c.690G>A	c.(688-690)gtG>gtA	p.V230V	OGDHL_ENST00000419399.1_Silent_p.V173V|OGDHL_ENST00000432695.1_Silent_p.V21V	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	230					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						AGAACTGCATCACACCAGGGG	0.602000													54	60					0	0	0.000781405	0	0
KMT2D	8085	broad.mit.edu	37	12	49420214	49420214	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr12:49420214G>A	ENST00000301067.7	-	48	15534	c.15535C>T	c.(15535-15537)Cgt>Tgt	p.R5179C		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		CCCCCCACACGGAACATGTGC	0.592000													10	23					0	0	0.000673444	0	0
MIR7162	102466227	broad.mit.edu	37	15	62539289	62539289	+	RNA	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr15:62539289C>T	ENST00000570077.1	-	0	300																											GCTGTGCACTCTCTCCTCCCT	0.612000													7	11					0	0	0.000157383	0	0
CDR1	1038	broad.mit.edu	37	X	139866304	139866304	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chrX:139866304C>T	ENST00000370532.2	-	1	419	c.228G>A	c.(226-228)agG>agA	p.R76R		NM_004065.2	NP_004056.2	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1, 34kDa	76	23 X 6 AA approximate repeats.									breast(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(2)|skin(4)|urinary_tract(1)	25	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				CCTTGTCTTCCCTCAAATCCA	0.463000													19	6					0	0	0.000132079	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				19	51					0	0	0.000175454	0	0
CCDC74A	90557	broad.mit.edu	37	2	132290454	132290454	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:132290454C>T	ENST00000295171.6	+	6	1032	c.894C>T	c.(892-894)tcC>tcT	p.S298S	CCDC74A_ENST00000467992.2_3'UTR|CCDC74A_ENST00000409856.3_Silent_p.S232S	NM_001258304.1|NM_001258305.1|NM_138770.2	NP_001245233.1|NP_001245234.1|NP_620125.1	Q96AQ1	CC74A_HUMAN	coiled-coil domain containing 74A	298										endometrium(4)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19						ACCTCAAGTCCCTCCTGGAAG	0.701000													17	16					0	0	0.000295444	0	0
TRAV26-2	28656	broad.mit.edu	37	14	22671215	22671215	+	RNA	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr14:22671215C>T	ENST00000390460.1	+	0	280																											GATCCTGCACCGTGCTACCTT	0.502000													5	13					0	0	0.000602214	0	0
LRP1B	53353	broad.mit.edu	37	2	141806610	141806610	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:141806610G>A	ENST00000389484.3	-	11	2705	c.1734C>T	c.(1732-1734)ttC>ttT	p.F578F		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	578					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GGCCAATTAGGAAACTGGTGG	0.428000										TSP Lung(27;0.18)			6	25					0	0	8.12818e-05	0	0
PDZD7	79955	broad.mit.edu	37	10	102789856	102789856	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr10:102789856G>C	ENST00000370215.3	-	2	346	c.121C>G	c.(121-123)Cga>Gga	p.R41G	PDZD7_ENST00000470414.1_Missense_Mutation_p.R41G	NM_024895.4	NP_079171.1	Q9H5P4	PDZD7_HUMAN	PDZ domain containing 7	41						cilium|nucleus	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22				Epithelial(162;6.98e-09)|all cancers(201;3.55e-07)		AGCAGGTATCGCGTTGCGGTG	0.652000													12	49					0	0	0.000151284	0	0
SYNE1	23345	broad.mit.edu	37	6	152719759	152719759	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr6:152719759G>C	ENST00000367255.5	-	49	7946	c.7345C>G	c.(7345-7347)Ctt>Gtt	p.L2449V	SYNE1_ENST00000341594.5_Missense_Mutation_p.L2487V|SYNE1_ENST00000448038.1_Missense_Mutation_p.L2456V|SYNE1_ENST00000423061.1_Missense_Mutation_p.L2456V|SYNE1_ENST00000265368.4_Missense_Mutation_p.L2449V	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2449					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TATACCTGAAGATCATGGAGC	0.448000										HNSCC(10;0.0054)			11	45					0	0	0.000673444	0	0
ARAP3	64411	broad.mit.edu	37	5	141051754	141051754	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr5:141051754G>A	ENST00000239440.4	-	10	1565	c.1500C>T	c.(1498-1500)gcC>gcT	p.A500A	ARAP3_ENST00000508305.1_Silent_p.A422A|ARAP3_ENST00000513878.1_Silent_p.A162A	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	500	Arf-GAP.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						ACTGCCGGTTGGCCCGATTAG	0.622000													25	52					0	0	0.000586117	0	0
VTN	7448	broad.mit.edu	37	17	26696734	26696734	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr17:26696734C>T	ENST00000226218.4	-	3	941	c.323G>A	c.(322-324)gGg>gAg	p.G108E	TMEM199_ENST00000509083.1_Intron|SARM1_ENST00000379061.4_Intron|CTB-96E2.3_ENST00000591482.1_RNA|SEBOX_ENST00000536498.1_5'UTR	NM_000638.3	NP_000629.3	P04004	VTNC_HUMAN	vitronectin	108					cell adhesion mediated by integrin|immune response|negative regulation of endopeptidase activity|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein binding|positive regulation of receptor-mediated endocytosis|positive regulation of smooth muscle cell migration|positive regulation of vascular endothelial growth factor receptor signaling pathway|smooth muscle cell-matrix adhesion	alphav-beta3 integrin-vitronectin complex|extracellular space	heparin binding|integrin binding|scavenger receptor activity			kidney(2)|large_intestine(7)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	13	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Urokinase(DB00013)	CTCAGGATTCCCTTTGGACTG	0.592000													17	14					0	0	0.00074312	0	0
MTTP	4547	broad.mit.edu	37	4	100521847	100521847	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr4:100521847G>C	ENST00000457717.1	+	10	1449	c.1193G>C	c.(1192-1194)gGa>gCa	p.G398A	MTTP_ENST00000511045.1_Missense_Mutation_p.G425A|RP11-766F14.1_ENST00000508578.1_RNA|MTTP_ENST00000265517.5_Missense_Mutation_p.G398A	NM_000253.2	NP_000244.2	P55157	MTP_HUMAN	microsomal triglyceride transfer protein	398	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(14)|lung(19)|ovary(4)|prostate(5)|skin(1)|urinary_tract(1)	57				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	TATGCCTGTGGATTTGCTTCT	0.393000													17	10					0	0	0.000132079	0	0
NPY	4852	broad.mit.edu	37	7	24325033	24325033	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr7:24325033C>T	ENST00000407573.1	+	3	464	c.174C>T	c.(172-174)ctC>ctT	p.L58L	NPY_ENST00000405982.1_Silent_p.L58L|NPY_ENST00000242152.2_Silent_p.L58L			P01303	NPY_HUMAN	neuropeptide Y	58					adult feeding behavior|calcium ion transport|cell proliferation|cellular component movement|central nervous system neuron development|cerebral cortex development|digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|neuron projection development|neuropeptide signaling pathway|positive regulation of appetite|synaptic transmission	cell|extracellular space	calcium channel regulator activity|G-protein coupled receptor activity|neuropeptide hormone activity			breast(1)|kidney(1)|large_intestine(4)|lung(2)|upper_aerodigestive_tract(1)	9						ACATCAACCTCATCACCAGGC	0.637000													11	12					0	0	0.00010058	0	0
PKP2	5318	broad.mit.edu	37	12	32945415	32945415	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr12:32945415C>T	ENST00000340811.4	-	13	2565	c.2457G>A	c.(2455-2457)aaG>aaA	p.K819K	PKP2_ENST00000070846.6_Silent_p.K863K	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2	863					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					AATCTGTCTTCTTAAACTGAG	0.423000													34	48					0	0	0.00111076	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36278216	36278216	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr19:36278216C>T	ENST00000007510.4	+	21	2893	c.2749C>T	c.(2749-2751)Cag>Tag	p.Q917*	ARHGAP33_ENST00000314737.5_Nonsense_Mutation_p.Q756*|ARHGAP33_ENST00000378944.5_Nonsense_Mutation_p.Q781*			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	917					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						GCAACAGAGCCAGCAGGAGTG	0.721000													8	15					0	0	0.000442599	0	0
SCFD1	23256	broad.mit.edu	37	14	31204066	31204066	+	Splice_Site	SNP	T	T	C			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr14:31204066T>C	ENST00000458591.2	+	24	2132		c.e24+2		SCFD1_ENST00000421551.3_Splice_Site|SCFD1_ENST00000396629.2_Splice_Site|SCFD1_ENST00000541123.1_Splice_Site|SCFD1_ENST00000544052.2_Splice_Site	NM_016106.3	NP_057190.2	Q8WVM8	SCFD1_HUMAN	sec1 family domain containing 1						post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)	13	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)		ATAAAACAGGTAAAGTATACA	0.358000													36	24					0	0	0.00058488	0	0
USP9X	8239	broad.mit.edu	37	X	41000634	41000634	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chrX:41000634C>T	ENST00000324545.7	+	9	1744	c.1111C>T	c.(1111-1113)Cga>Tga	p.R371*	USP9X_ENST00000378308.2_Nonsense_Mutation_p.R371*	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	371					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						CTATACTCATCGACATGGTAA	0.358000													6	3					0	0	3.59834e-05	0	0
NLRP4	147945	broad.mit.edu	37	19	56388493	56388493	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr19:56388493G>T	ENST00000301295.6	+	8	3079	c.2657G>T	c.(2656-2658)cGg>cTg	p.R886L	NLRP4_ENST00000587891.1_Missense_Mutation_p.R811L|NLRP4_ENST00000346986.5_Missense_Mutation_p.R830L	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	886							ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CTGTTGTGTCGGGCTCTGACG	0.498000													5	119					8.12818e-05	0.00106097	8.12818e-05	1	0
PRR23C	389152	broad.mit.edu	37	3	138763024	138763024	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr3:138763024C>T	ENST00000413199.1	-	1	710	c.439G>A	c.(439-441)Gag>Aag	p.E147K	MRPS22_ENST00000495075.1_Intron|PRR23C_ENST00000502927.2_Missense_Mutation_p.E147K	NM_001134657.1	NP_001128129.1	Q6ZRP0	PR23C_HUMAN	proline rich 23C	147										breast(2)|lung(7)|skin(2)	11						GCAGCGATCTCTGGGACAGAT	0.662000													4	7					0	0	0.000602214	0	0
GPR98	84059	broad.mit.edu	37	5	89949028	89949028	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr5:89949028G>A	ENST00000405460.2	+	20	3733	c.3637G>A	c.(3637-3639)Gga>Aga	p.G1213R		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1213					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TGTTACAGGTGGATCCCCAGG	0.398000													6	3					0	0	3.59834e-05	0	0
HERC3	8916	broad.mit.edu	37	4	89591116	89591116	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr4:89591116C>T	ENST00000402738.1	+	15	1978	c.1739C>T	c.(1738-1740)cCc>cTc	p.P580L	HERC3_ENST00000543130.1_Missense_Mutation_p.P24L|HERC3_ENST00000264345.3_Missense_Mutation_p.P580L	NM_001271602.1|NM_014606.1	NP_001258531.1|NP_055421.1	Q15034	HERC3_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 3	580					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|prostate(2)|skin(2)	45				OV - Ovarian serous cystadenocarcinoma(123;0.000319)		TTCTTAATTCCCGTACTGTTT	0.428000													22	14					0	0	0.000229342	0	0
SORCS3	22986	broad.mit.edu	37	10	107012560	107012560	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr10:107012560C>T	ENST00000369701.3	+	23	3360	c.3133C>T	c.(3133-3135)Ctc>Ttc	p.L1045F		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	1045						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GGACCAGATCCTCATTGCCGT	0.527000													12	51					0	0	0.000151284	0	0
MXRA5	25878	broad.mit.edu	37	X	3241141	3241141	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chrX:3241141C>T	ENST00000217939.6	-	5	2739	c.2585G>A	c.(2584-2586)aGc>aAc	p.S862N		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	862						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TAGCCCCATGCTGGCTGAGGA	0.473000													40	4					0	0	0.000270559	0	0
GAL3ST1	9514	broad.mit.edu	37	22	30953357	30953357	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr22:30953357G>A	ENST00000402321.1	-	2	340	c.23C>T	c.(22-24)cCc>cTc	p.P8L	GAL3ST1_ENST00000406361.1_Missense_Mutation_p.P8L|GAL3ST1_ENST00000401975.1_Missense_Mutation_p.P8L|GAL3ST1_ENST00000402369.1_Missense_Mutation_p.P8L|GAL3ST1_ENST00000406955.1_Missense_Mutation_p.P8L|GAL3ST1_ENST00000338911.5_Missense_Mutation_p.P8L|GAL3ST1_ENST00000443111.2_Missense_Mutation_p.P8L			Q99999	G3ST1_HUMAN	galactose-3-O-sulfotransferase 1	8					protein N-linked glycosylation	Golgi membrane|integral to plasma membrane|membrane fraction	galactosylceramide sulfotransferase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	21						GGACTCCCAGGGCTTCTTCTG	0.652000													51	35					0	0	0.000781405	0	0
FOXR2	139628	broad.mit.edu	37	X	55650514	55650514	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chrX:55650514G>A	ENST00000339140.3	+	1	682	c.370G>A	c.(370-372)Gag>Aag	p.E124K		NM_198451.3	NP_940853.1	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	124					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	19						TAACTGCTCAGAGGACAAAGT	0.517000													12	1					0	0	0.00010058	0	0
ZNF235	9310	broad.mit.edu	37	19	44792789	44792789	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr19:44792789C>T	ENST00000291182.4	-	5	901	c.799G>A	c.(799-801)Gaa>Aaa	p.E267K	ZNF235_ENST00000589799.1_Intron|ZNF235_ENST00000589248.1_Intron	NM_004234.4	NP_004225.3	Q14590	ZN235_HUMAN	zinc finger protein 235	267					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	29		Prostate(69;0.0352)|all_neural(266;0.116)				TCTTCACATTCATTACCCTGG	0.418000													5	32					0	0	0.000602214	0	0
BCLAF1	9774	broad.mit.edu	37	6	136599030	136599030	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr6:136599030G>A	ENST00000531224.1	-	4	1241	c.989C>T	c.(988-990)aCt>aTt	p.T330I	BCLAF1_ENST00000392348.2_Missense_Mutation_p.T328I|BCLAF1_ENST00000353331.4_Missense_Mutation_p.T328I|BCLAF1_ENST00000530767.1_Missense_Mutation_p.T330I|BCLAF1_ENST00000527536.1_Missense_Mutation_p.T330I|BCLAF1_ENST00000527759.1_Missense_Mutation_p.T328I	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	330					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		AGTCTTTGCAGTTTCCTGATC	0.378000													5	37					0	0	3.59834e-05	0	0
DYNC2H1	79659	broad.mit.edu	37	11	102988580	102988580	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr11:102988580A>T	ENST00000375735.2	+	6	1131	c.987A>T	c.(985-987)aaA>aaT	p.K329N	DYNC2H1_ENST00000398093.3_Missense_Mutation_p.K329N|DYNC2H1_ENST00000334267.7_Missense_Mutation_p.K329N	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	329	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		AACTTGGCAAACGCCTTGAAG	0.333000													8	26					0	0	0.000157383	0	0
SRL	6345	broad.mit.edu	37	16	4242966	4242966	+	Splice_Site	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr16:4242966C>T	ENST00000399609.3	-	6	623		c.e6-1		SRL_ENST00000537996.1_Splice_Site	NM_001098814.1	NP_001092284.1	Q86TD4	SRCA_HUMAN	sarcalumenin							sarcoplasmic reticulum lumen	GTP binding|GTPase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(3)|skin(3)	21						AAGGGGTAGCCTTTGGGAGAC	0.517000													12	18					0	0	0.000219431	0	0
NIPBL	25836	broad.mit.edu	37	5	37022475	37022475	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr5:37022475C>T	ENST00000282516.8	+	29	6056	c.5557C>T	c.(5557-5559)Ctg>Ttg	p.L1853L	NIPBL_ENST00000448238.2_Silent_p.L1853L	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	1853					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			TTATGATATGCTGATTGAAAG	0.333000													16	36					0	0	0.00074312	0	0
FAM60A	58516	broad.mit.edu	37	12	31448266	31448266	+	Splice_Site	SNP	A	A	G			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr12:31448266A>G	ENST00000337682.4	-	3	498	c.128_splice	c.e3-1	p.L44_splice	FAM60A_ENST00000542983.1_5'UTR|FAM60A_ENST00000539409.1_Intron|FAM60A_ENST00000454658.2_Splice_Site_p.L44_splice|FAM60A_ENST00000395766.1_5'UTR	NM_001135812.1	NP_001129284.1	Q9NP50	FA60A_HUMAN	family with sequence similarity 60, member A	44										large_intestine(1)|lung(2)	3	all_cancers(9;5.22e-13)|all_epithelial(9;4e-13)|all_lung(12;1.2e-11)|Lung NSC(12;2.17e-09)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0207)|Lung SC(12;0.0592)|Esophageal squamous(101;0.162)					GTCTCATGCAATCTGATAAGA	0.383000													12	55					0	0	0.000219431	0	0
AGL	178	broad.mit.edu	37	1	100353539	100353539	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:100353539C>T	ENST00000294724.4	+	21	3165	c.2687C>T	c.(2686-2688)gCc>gTc	p.A896V	AGL_ENST00000361522.4_Missense_Mutation_p.A879V|AGL_ENST00000361915.3_Missense_Mutation_p.A896V|AGL_ENST00000361302.3_Missense_Mutation_p.A880V|AGL_ENST00000370161.2_Missense_Mutation_p.A880V|AGL_ENST00000370165.3_Missense_Mutation_p.A896V|AGL_ENST00000370163.3_Missense_Mutation_p.A896V	NM_000028.2	NP_000019.2	P35573	GDE_HUMAN	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	896					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(9)|lung(35)|ovary(1)|prostate(4)|skin(3)|urinary_tract(1)	69		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		CTTAGTCTTGCCTCCAGATTA	0.348000													17	18					0	0	0.000132079	0	0
NOP9	161424	broad.mit.edu	37	14	24771298	24771298	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr14:24771298C>T	ENST00000267425.3	+	4	1029	c.936C>T	c.(934-936)tcC>tcT	p.S312S	NOP9_ENST00000396802.3_Silent_p.S312S	NM_174913.1	NP_777573.1			NOP9 nucleolar protein																		CTCGCGGTTCCTCAGTAGATG	0.498000													58	38					0	0	0.000781405	0	0
VTN	7448	broad.mit.edu	37	17	26696733	26696733	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr17:26696733C>T	ENST00000226218.4	-	3	942	c.324G>A	c.(322-324)ggG>ggA	p.G108G	TMEM199_ENST00000509083.1_Intron|SARM1_ENST00000379061.4_Intron|CTB-96E2.3_ENST00000591482.1_RNA|SEBOX_ENST00000536498.1_5'UTR	NM_000638.3	NP_000629.3	P04004	VTNC_HUMAN	vitronectin	108					cell adhesion mediated by integrin|immune response|negative regulation of endopeptidase activity|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein binding|positive regulation of receptor-mediated endocytosis|positive regulation of smooth muscle cell migration|positive regulation of vascular endothelial growth factor receptor signaling pathway|smooth muscle cell-matrix adhesion	alphav-beta3 integrin-vitronectin complex|extracellular space	heparin binding|integrin binding|scavenger receptor activity			kidney(2)|large_intestine(7)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	13	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Urokinase(DB00013)	GCTCAGGATTCCCTTTGGACT	0.597000													18	14					0	0	0.000958276	0	0
ZNF335	63925	broad.mit.edu	37	20	44592393	44592393	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr20:44592393C>T	ENST00000322927.2	-	8	1439	c.1339G>A	c.(1339-1341)Ggc>Agc	p.G447S	ZNF335_ENST00000426788.1_Missense_Mutation_p.G292S	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	447					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				TATTTCTTGCCTAGGAAGCGC	0.607000													53	148					0	0	0.000781405	0	0
GPR98	84059	broad.mit.edu	37	5	90000297	90000297	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr5:90000297G>A	ENST00000405460.2	+	36	8474	c.8378G>A	c.(8377-8379)aGg>aAg	p.R2793K		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	2793					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TATGATGTCAGGACACAAGGT	0.303000													4	3					0	0	0.00024832	0	0
MAP3K19	80122	broad.mit.edu	37	2	135738899	135738899	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:135738899T>C	ENST00000375845.3	-	9	3442	c.3412A>G	c.(3412-3414)Att>Gtt	p.I1138V	MAP3K19_ENST00000315513.3_5'UTR|MAP3K19_ENST00000375844.3_Missense_Mutation_p.I320V|MAP3K19_ENST00000392915.1_3'UTR|MAP3K19_ENST00000392918.3_Missense_Mutation_p.I272V|MAP3K19_ENST00000358371.4_Missense_Mutation_p.I1025V|MAP3K19_ENST00000392917.3_Missense_Mutation_p.I270V	NM_025052.3	NP_079328.3			mitogen-activated protein kinase kinase kinase 19																		TCCATGAAAATGCTCACAGTG	0.408000													17	45					0	0	0.000958276	0	0
GPI	2821	broad.mit.edu	37	19	34887329	34887329	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr19:34887329C>T	ENST00000415930.3	+	13	1389	c.1219C>T	c.(1219-1221)Cac>Tac	p.H407Y	GPI_ENST00000356487.5_Missense_Mutation_p.H396Y|GPI_ENST00000586425.1_Missense_Mutation_p.H396Y	NM_001184722.1	NP_001171651.1	P06744	G6PI_HUMAN	glucose-6-phosphate isomerase	396					angiogenesis|gluconeogenesis|glycolysis|hemostasis|humoral immune response	cytosol|extracellular space|nucleus|plasma membrane	cytokine activity|glucose-6-phosphate isomerase activity|growth factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	25	Esophageal squamous(110;0.162)					CCAGCTCATCCACCAAGGTAG	0.567000													15	27					0	0	0.000308642	0	0
KIF25	3834	broad.mit.edu	37	6	168445549	168445549	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr6:168445549G>A	ENST00000443060.2	+	10	1419	c.1028G>A	c.(1027-1029)aGc>aAc	p.S343N	KIF25_ENST00000354419.2_Missense_Mutation_p.S343N|KIF25_ENST00000351261.3_Missense_Mutation_p.S291N			Q9UIL4	KIF25_HUMAN	kinesin family member 25	343					microtubule-based movement|mitotic sister chromatid segregation	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		ATTTCTCCCAGCCAGAGGCAC	0.552000													18	82					0	0	0.000229342	0	0
BSG	682	broad.mit.edu	37	19	582305	582305	+	Splice_Site	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr19:582305G>A	ENST00000333511.3	+	7	1139		c.e7-1		BSG_ENST00000346916.4_Splice_Site|BSG_ENST00000353555.4_Splice_Site|BSG_ENST00000545507.2_Splice_Site	NM_001728.3	NP_001719.2	P35613	BASI_HUMAN	basigin						blood coagulation|cell surface receptor linked signaling pathway|leukocyte migration|pyruvate metabolic process	Golgi membrane|integral to membrane|melanosome	lactate transmembrane transporter activity|mannose binding|protein binding			central_nervous_system(1)|endometrium(3)|lung(1)	5		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCTTCTTCAGATGACGACGC	0.637000													19	30					0	0	0.00047179	0	0
RPAP1	26015	broad.mit.edu	37	15	41826993	41826993	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr15:41826993G>A	ENST00000304330.4	-	6	798	c.682C>T	c.(682-684)Cat>Tat	p.H228Y	RPAP1_ENST00000561603.1_Missense_Mutation_p.H228Y	NM_015540.2	NP_056355.2	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	228						nucleus	DNA binding|DNA-directed RNA polymerase activity			NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(16)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	45		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		TTCTCTTCATGGATAGTCTGG	0.582000													15	26					0	0	0.000308642	0	0
BAI2	576	broad.mit.edu	37	1	32221987	32221987	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:32221987G>A	ENST00000373658.3	-	4	792	c.451C>T	c.(451-453)Ctg>Ttg	p.L151L	BAI2_ENST00000398556.3_Silent_p.L154L|BAI2_ENST00000398547.1_Silent_p.L139L|BAI2_ENST00000373655.2_Silent_p.L151L|BAI2_ENST00000398542.1_Silent_p.L139L|BAI2_ENST00000527361.1_Silent_p.L151L|BAI2_ENST00000257070.4_Silent_p.L151L|BAI2_ENST00000398538.1_Silent_p.L139L	NM_001703.2	NP_001694.2	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	151					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|large_intestine(7)|liver(2)|lung(24)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	55		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		TCGAAGTGCAGGAAGGTAAAG	0.687000													13	10					0	0	0.00010058	0	0
NCR1	9437	broad.mit.edu	37	19	55417933	55417933	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr19:55417933G>A	ENST00000594765.1	+	3	148	c.123G>A	c.(121-123)aaG>aaA	p.K41K	NCR1_ENST00000338835.5_Silent_p.K41K|NCR1_ENST00000447255.1_Silent_p.K41K|NCR1_ENST00000357397.5_Intron|NCR1_ENST00000598576.1_Silent_p.K29K|NCR1_ENST00000291890.4_Silent_p.K41K|NCR1_ENST00000350790.5_Intron			O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	41	Ig-like 1.				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	18				GBM - Glioblastoma multiforme(193;0.0449)		TGGTTCCAAAGGAAAAGCAAG	0.542000													17	64					0	0	0.000958276	0	0
CUZD1	50624	broad.mit.edu	37	10	124598677	124598677	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr10:124598677G>A	ENST00000368904.1	-	5	1253	c.304C>T	c.(304-306)Ctg>Ttg	p.L102L	CUZD1_ENST00000392790.1_Silent_p.L102L|CUZD1_ENST00000545804.1_Silent_p.L102L			Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1	102	CUB 1.				cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|stomach(1)	39		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		TGCCCTAGCAGAGGCCCATTG	0.418000													36	107					0	0	0.000228196	0	0
STARD10	10809	broad.mit.edu	37	11	72492032	72492032	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr11:72492032C>T	ENST00000334805.6	-	2	1114	c.195G>A	c.(193-195)ctG>ctA	p.L65L	STARD10_ENST00000538536.1_Intron|STARD10_ENST00000538437.1_5'UTR|STARD10_ENST00000545082.1_Intron|STARD10_ENST00000543304.1_Silent_p.L65L|ARAP1_ENST00000359373.5_Intron	NM_006645.2	NP_006636.2	Q9Y365	PCTL_HUMAN	StAR-related lipid transfer (START) domain containing 10	65	START.									endometrium(4)|large_intestine(1)|lung(2)|prostate(1)	8			BRCA - Breast invasive adenocarcinoma(5;7.08e-07)			TGATCTTGTGCAGCGTCCGAT	0.612000													39	121					0	0	0.000509022	0	0
SDAD1P1	157489	broad.mit.edu	37	8	26237767	26237767	+	RNA	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr8:26237767C>T	ENST00000519902.1	-	0	2181																											GCTGTTGTCTCTTTTACAGCA	0.413000													10	23					0	0	0.000442599	0	0
PREX2	80243	broad.mit.edu	37	8	68995569	68995569	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr8:68995569C>T	ENST00000288368.4	+	18	2250	c.1973C>T	c.(1972-1974)tCg>tTg	p.S658L	PREX2_ENST00000529398.1_3'UTR|RP11-403D15.2_ENST00000526901.1_RNA	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	658	PDZ 1.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						TTCCTGAAATCGTGTTTAAAC	0.353000													31	42					0	0	0.000692331	0	0
MYO9A	4649	broad.mit.edu	37	15	72192092	72192092	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr15:72192092G>A	ENST00000356056.5	-	24	3878	c.3406C>T	c.(3406-3408)Caa>Taa	p.Q1136*	MYO9A_ENST00000563542.1_5'UTR|MYO9A_ENST00000444904.1_Nonsense_Mutation_p.Q1117*|MYO9A_ENST00000566885.1_Nonsense_Mutation_p.Q756*|MYO9A_ENST00000424560.1_Nonsense_Mutation_p.Q1136*|MYO9A_ENST00000564571.1_Nonsense_Mutation_p.Q1136*	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	1136	IQ 4.|Neck or regulatory domain.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						CTTTGTTCTTGGTACCTTTTA	0.368000													28	36					0	0	0.000279167	0	0
ZNF831	128611	broad.mit.edu	37	20	57768418	57768418	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr20:57768418G>A	ENST00000371030.2	+	1	2344	c.2344G>A	c.(2344-2346)Gac>Aac	p.D782N		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	782						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					AGTTTGGCCGGACCCCAAGCT	0.657000													7	23					0	0	0.000274275	0	0
FAM171B	165215	broad.mit.edu	37	2	187627296	187627296	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:187627296C>T	ENST00000304698.5	+	8	2430	c.2227C>T	c.(2227-2229)Cta>Tta	p.L743L		NM_177454.3	NP_803237.3	Q6P995	F171B_HUMAN	family with sequence similarity 171, member B	743						integral to membrane	DNA binding			NS(1)|breast(6)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(22)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						AGATTTAGACCTAAGCAGCAG	0.488000													10	33					0	0	0.000151284	0	0
AHRR	57491	broad.mit.edu	37	5	434652	434652	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr5:434652G>A	ENST00000316418.5	+	12	1907	c.1863G>A	c.(1861-1863)agG>agA	p.R621R	AHRR_ENST00000505113.1_Silent_p.R603R|AHRR_ENST00000506456.1_Silent_p.R459R|AHRR_ENST00000512529.1_Silent_p.R449R	NM_020731.4	NP_065782.2	A9YTQ3	AHRR_HUMAN	aryl-hydrocarbon receptor repressor	603	Needed for transcriptional repression (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)|endometrium(4)|large_intestine(1)|lung(12)|prostate(1)	20			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			CCCATGGGAGGGCCACTGCTG	0.672000													4	11					0	0	0.00024832	0	0
PCDHA7	56141	broad.mit.edu	37	5	140216216	140216216	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr5:140216216T>C	ENST00000525929.1	+	1	2248	c.2248T>C	c.(2248-2250)Ttc>Ctc	p.F750L	PCDHA4_ENST00000512229.2_Intron|PCDHA7_ENST00000378125.3_Missense_Mutation_p.F750L|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000530339.1_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGCTGGTCATTCTCCCAGCA	0.637000													7	25					0	0	0.000157383	0	0
CDH18	1016	broad.mit.edu	37	5	19483644	19483644	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr5:19483644G>A	ENST00000507958.1	-	14	2638	c.1648C>T	c.(1648-1650)Ctg>Ttg	p.L550L	CDH18_ENST00000506372.1_Intron|CDH18_ENST00000382275.1_Silent_p.L550L|CDH18_ENST00000274170.4_Silent_p.L550L|CDH18_ENST00000502796.1_Intron			Q13634	CAD18_HUMAN	cadherin 18, type 2	550	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CGCCTTGTCAGAATGCTGGCT	0.428000													35	60					0	0	0.000228196	0	0
GPR112	139378	broad.mit.edu	37	X	135427956	135427956	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chrX:135427956C>T	ENST00000394143.1	+	6	2382	c.2091C>T	c.(2089-2091)tcC>tcT	p.S697S	GPR112_ENST00000287534.4_Silent_p.S634S|GPR112_ENST00000370652.1_Silent_p.S697S|GPR112_ENST00000394141.1_Silent_p.S492S|GPR112_ENST00000412101.1_Silent_p.S492S	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	697					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					AATATTTATCCGCAACTACCA	0.398000													24	2					0	0	0.00047179	0	0
SIPA1	6494	broad.mit.edu	37	11	65417244	65417244	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr11:65417244C>T	ENST00000394224.3	+	12	2950	c.2654C>T	c.(2653-2655)cCc>cTc	p.P885L	SIPA1_ENST00000394227.3_Missense_Mutation_p.P783L|SIPA1_ENST00000534313.1_Missense_Mutation_p.P885L|SIPA1_ENST00000527525.1_Missense_Mutation_p.P783L	NM_153253.29	NP_694985.29	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated 1	885					cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	10						CCAGGCAGTCCCAGTGGCTCT	0.597000													17	36					0	0	0.00074312	0	0
LINGO4	339398	broad.mit.edu	37	1	151773683	151773683	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:151773683C>T	ENST00000368820.3	-	2	2435	c.1498G>A	c.(1498-1500)Gaa>Aaa	p.E500K		NM_001004432.2	NP_001004432.1	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	500	Ig-like C2-type.					integral to membrane				breast(2)|cervix(1)|endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TGGATGACTTCCAGCCAGGTC	0.572000													91	65					0	0	0.000781405	0	0
MYB	4602	broad.mit.edu	37	6	135516936	135516936	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr6:135516936C>T	ENST00000341911.5	+	9	1198	c.999C>T	c.(997-999)gcC>gcT	p.A333A	MYB_ENST00000533624.1_Silent_p.A298A|MYB_ENST00000528774.1_Silent_p.A330A|MYB_ENST00000442647.2_Silent_p.A330A|MYB_ENST00000525369.1_Intron|MYB_ENST00000316528.8_Silent_p.A333A|MYB-AS1_ENST00000455534.1_RNA|MYB_ENST00000531845.1_3'UTR|MYB_ENST00000367814.4_Silent_p.A333A|MYB_ENST00000527615.1_Silent_p.A333A|MYB_ENST00000534121.1_Silent_p.A333A|MYB_ENST00000534044.1_Silent_p.A333A	NM_001130173.1|NM_001161656.1|NM_001161658.1	NP_001123645.1|NP_001155128.1|NP_001155130.1	P10242	MYB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog	333	Negative regulatory domain (By similarity).				blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	28	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)		CCACCATTGCCGACCACACCA	0.552000			T	NFIB	adenoid cystic carcinoma								12	51					0	0	0.00010058	0	0
DDX42	11325	broad.mit.edu	37	17	61889322	61889322	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr17:61889322A>G	ENST00000578681.1	+	15	2030	c.1429A>G	c.(1429-1431)Att>Gtt	p.I477V	DDX42_ENST00000389924.2_Missense_Mutation_p.I477V|DDX42_ENST00000583590.1_Missense_Mutation_p.I477V|DDX42_ENST00000359353.5_Missense_Mutation_p.I358V|DDX42_ENST00000457800.2_Missense_Mutation_p.I477V	NM_007372.2	NP_031398.2	Q86XP3	DDX42_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 42	477					protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)	46						GATTGTGGAGATTCTCCATTC	0.453000													38	368					0	0	0.000953801	0	0
RASA2	5922	broad.mit.edu	37	3	141295844	141295844	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr3:141295844G>A	ENST00000286364.3	+	15	1521	c.1486G>A	c.(1486-1488)Gac>Aac	p.D496N	RASA2_ENST00000452898.1_Missense_Mutation_p.D496N			Q15283	RASA2_HUMAN	RAS p21 protein activator 2	496	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	34						TCCTGCAGATGACCCTCATGT	0.348000													24	83					0	0	0.000375601	0	0
OTUD7A	161725	broad.mit.edu	37	15	31793901	31793901	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr15:31793901C>T	ENST00000382902.1	-	8	1255	c.1163G>A	c.(1162-1164)aGa>aAa	p.R388K	OTUD7A_ENST00000307050.4_Missense_Mutation_p.R381K			Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	381	Catalytic (By similarity).|TRAF-binding (By similarity).					cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			endometrium(7)|large_intestine(4)|lung(11)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	30		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		ACCTTGTTCTCTTTGCTGGTC	0.577000													11	50					0	0	0.00010058	0	0
ADH1A	124	broad.mit.edu	37	4	100205660	100205660	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr4:100205660C>T	ENST00000209668.2	-	5	576	c.463G>A	c.(463-465)Gaa>Aaa	p.E155K	RP11-696N14.1_ENST00000500358.2_RNA	NM_000667.3	NP_000658.1	P07327	ADH1A_HUMAN	alcohol dehydrogenase 1A (class I), alpha polypeptide	155					ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)	25				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)	ACTGCATTTTCATCCACCACT	0.522000													17	7					0	0	0.000422831	0	0
CASS4	57091	broad.mit.edu	37	20	55027732	55027732	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr20:55027732C>T	ENST00000371336.3	+	5	1701	c.1500C>T	c.(1498-1500)gtC>gtT	p.V500V	CASS4_ENST00000434344.1_Intron|CASS4_ENST00000360314.3_Silent_p.V500V	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	500					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						CCCGAGGAGTCCATGGGACTG	0.478000													45	36					0	0	0.000680045	0	0
NDUFAF5	79133	broad.mit.edu	37	20	13769244	13769244	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr20:13769244C>T	ENST00000378106.5	+	3	392	c.273C>T	c.(271-273)ccC>ccT	p.P91P	NDUFAF5_ENST00000463598.1_Silent_p.P91P|NDUFAF5_ENST00000475968.1_3'UTR	NM_024120.4	NP_077025.2	Q5TEU4	CT007_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 5	91					mitochondrial respiratory chain complex I assembly	extrinsic to mitochondrial inner membrane	methyltransferase activity										GAAATTTCCCCCTTGCTTTGG	0.303000													43	13					0	0	0.000781405	0	0
C7orf43	55262	broad.mit.edu	37	7	99754797	99754797	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr7:99754797A>C	ENST00000316937.3	-	5	950	c.765T>G	c.(763-765)gaT>gaG	p.D255E	C7orf43_ENST00000419841.1_Missense_Mutation_p.D23E|C7orf43_ENST00000498638.1_5'UTR|C7orf43_ENST00000457641.1_5'UTR	NM_018275.3	NP_060745.3	Q8WVR3	CG043_HUMAN	chromosome 7 open reading frame 43	255										breast(1)|endometrium(3)|large_intestine(3)|lung(2)|prostate(1)	10	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GGATTCGGATATCCCAGATGG	0.577000													9	23					0	0	0.000274275	0	0
ZSCAN32	54925	broad.mit.edu	37	16	3432960	3432960	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr16:3432960C>G	ENST00000396852.4	-	7	2293	c.1986G>C	c.(1984-1986)agG>agC	p.R662S	LA16c-306E5.2_ENST00000575785.1_RNA|ZSCAN32_ENST00000439568.2_Missense_Mutation_p.R373S|ZSCAN32_ENST00000396846.3_Missense_Mutation_p.R662S|ZSCAN32_ENST00000304926.3_Missense_Mutation_p.R450S					zinc finger and SCAN domain containing 32																		AGTGAGAACACCTGTAAGGCT	0.493000													16	49					0	0	0.000308642	0	0
EVI5	7813	broad.mit.edu	37	1	93201978	93201978	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:93201978C>T	ENST00000370331.1	-	2	267	c.258G>A	c.(256-258)ctG>ctA	p.L86L	EVI5_ENST00000540033.1_Silent_p.L86L|EVI5_ENST00000543509.1_Silent_p.L86L	NM_005665.4	NP_005656.4	O60447	EVI5_HUMAN	ecotropic viral integration site 5	86	Interaction with alpha-tubulin, gamma- tubulin, BIRC5 and FBXO5.|Ser-rich.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(1)|skin(1)	38		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		CCAGTTTAGCCAGGAGTTCTA	0.403000													6	37					0	0	3.59834e-05	0	0
DACH1	1602	broad.mit.edu	37	13	72440119	72440119	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr13:72440119C>T	ENST00000305425.4	-	1	1211	c.789G>A	c.(787-789)gtG>gtA	p.V263V	DACH1_ENST00000359684.2_Silent_p.V263V|DACH1_ENST00000354591.4_Silent_p.V263V|DACH1_ENST00000313174.7_Silent_p.V263V	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)	261	DACHbox-N.|Interaction with SIX6 and HDAC3 (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		TGCAGCGGTTCACTCCTGGCT	0.622000													17	10					0	0	0.000175454	0	0
SDK1	221935	broad.mit.edu	37	7	4150372	4150372	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr7:4150372G>T	ENST00000404826.2	+	23	3541	c.3402G>T	c.(3400-3402)gaG>gaT	p.E1134D	SDK1_ENST00000389531.3_Missense_Mutation_p.E1134D	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1134	Fibronectin type-III 5.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		AGATGCTGGAGATCCCAAACC	0.557000													20	45					5.45024e-15	7.25404e-14	0.00047179	1	0
SETD1A	9739	broad.mit.edu	37	16	30977592	30977592	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr16:30977592T>A	ENST00000262519.8	+	8	3076	c.2390T>A	c.(2389-2391)aTg>aAg	p.M797K		NM_014712.1	NP_055527.1	O15047	SET1A_HUMAN	SET domain containing 1A	797					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(21)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	59						GTGCTCGCCATGCTGGTCCAG	0.637000													5	19					0	0	3.59834e-05	0	0
PHF21A	51317	broad.mit.edu	37	11	46001479	46001479	+	Silent	SNP	T	T	G			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr11:46001479T>G	ENST00000257821.4	-	6	815	c.192A>C	c.(190-192)gtA>gtC	p.V64V	PHF21A_ENST00000418153.2_Silent_p.V64V|PHF21A_ENST00000323180.6_Silent_p.V64V	NM_001101802.1	NP_001095272.1	Q96BD5	PF21A_HUMAN	PHD finger protein 21A	64	Gln-rich.				blood coagulation|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(10)|lung(9)|skin(2)|upper_aerodigestive_tract(2)	29						GTTCTTGCTTTACTATCAGGT	0.388000													21	78					0	0	0.000375601	0	0
COL6A6	131873	broad.mit.edu	37	3	130282243	130282243	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr3:130282243C>T	ENST00000358511.6	+	2	427	c.396C>T	c.(394-396)ccC>ccT	p.P132P	COL6A6_ENST00000453409.2_Silent_p.P132P	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	132	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						AACAGTTTCCCCCAATTCTAG	0.507000													16	21					0	0	0.000958276	0	0
RCL1	10171	broad.mit.edu	37	9	4826983	4826983	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr9:4826983C>T	ENST00000381750.4	+	3	557	c.334C>T	c.(334-336)Ccg>Tcg	p.P112S	RCL1_ENST00000381732.3_Missense_Mutation_p.P112S	NM_005772.3	NP_005763.3	Q9Y2P8	RCL1_HUMAN	RNA terminal phosphate cyclase-like 1	112					ribosome biogenesis|RNA processing	nucleolus	RNA-3'-phosphate cyclase activity			breast(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	9	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0206)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0244)		TATGAAGCACCCGTTAAAAAT	0.453000													41	42					0	0	0.000228196	0	0
LMX1A	4009	broad.mit.edu	37	1	165180005	165180005	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:165180005C>T	ENST00000342310.3	-	6	1060	c.678G>A	c.(676-678)gaG>gaA	p.E226E	LMX1A_ENST00000367893.4_Silent_p.E226E|RP11-38C18.2_ENST00000457106.1_RNA|LMX1A_ENST00000294816.2_Silent_p.E226E|LMX1A_ENST00000489443.2_5'UTR	NM_177398.3	NP_796372.1	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	226						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|central_nervous_system(3)|cervix(2)|endometrium(4)|large_intestine(6)|lung(10)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)	35	all_hematologic(923;0.248)					CAGCCAGAGTCTCTCTCACCT	0.478000													27	18					0	0	0.000184323	0	0
SLTM	79811	broad.mit.edu	37	15	59192026	59192026	+	Missense_Mutation	SNP	T	T	G			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr15:59192026T>G	ENST00000380516.2	-	7	787	c.700A>C	c.(700-702)Act>Cct	p.T234P	SLTM_ENST00000536328.1_Intron	NM_001013843.1|NM_024755.2	NP_001013865.1|NP_079031.2	Q9NWH9	SLTM_HUMAN	SAFB-like, transcription modulator	234	Glu-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TCTTTCACAGTCGTATGAGCT	0.463000													65	43					0	0	0.000781405	0	0
PML	5371	broad.mit.edu	37	15	74290560	74290560	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr15:74290560C>T	ENST00000565898.1	+	2	429	c.345C>T	c.(343-345)cgC>cgT	p.R115R	PML_ENST00000354026.6_Silent_p.R115R|PML_ENST00000436891.3_Silent_p.R115R|PML_ENST00000435786.2_Silent_p.R115R|PML_ENST00000359928.4_Silent_p.R115R|PML_ENST00000563500.1_Silent_p.R115R|PML_ENST00000395135.3_Silent_p.R115R|PML_ENST00000569477.1_Silent_p.R115R|PML_ENST00000569965.1_Silent_p.R115R|PML_ENST00000567543.1_Silent_p.R115R|PML_ENST00000268058.3_Silent_p.R115R|PML_ENST00000268059.6_Silent_p.R115R|PML_ENST00000395132.2_Silent_p.R115R|PML_ENST00000564428.1_Silent_p.R115R			P29590	PML_HUMAN	promyelocytic leukemia	115					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	31						TGCAGCGGCGCCTGTCGGTGT	0.642000			T	"""RARA, PAX5"""	"""APL, ALL"""								25	24					0	0	0.000586117	0	0
INSR	3643	broad.mit.edu	37	19	7122746	7122746	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr19:7122746C>A	ENST00000341500.5	-	18	3411	c.3372G>T	c.(3370-3372)atG>atT	p.M1124I	INSR_ENST00000302850.5_Missense_Mutation_p.M1136I	NM_001079817.1	NP_001073285.1	P06213	INSR_HUMAN	insulin receptor	1136	Protein kinase.				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			breast(1)|central_nervous_system(4)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(4)|prostate(4)|skin(3)|stomach(2)|urinary_tract(2)	66					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCATCTGAATCATCTCTTGAA	0.572000													77	271					7.539e-32	1.00836e-30	0.000781405	1	0
ZNF614	80110	broad.mit.edu	37	19	52521670	52521670	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr19:52521670G>T	ENST00000270649.6	-	3	637	c.93C>A	c.(91-93)aaC>aaA	p.N31K	ZNF614_ENST00000356322.6_Missense_Mutation_p.N31K	NM_025040.3	NP_079316.2	Q8N883	ZN614_HUMAN	zinc finger protein 614	31	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	24		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00513)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		CCCGGTACAGGTTCTTCTGAG	0.498000													36	34					3.03874e-20	4.0544e-19	0.00058488	1	0
SLCO6A1	133482	broad.mit.edu	37	5	101748766	101748766	+	Silent	SNP	T	T	G			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr5:101748766T>G	ENST00000506729.1	-	9	1725	c.1554A>C	c.(1552-1554)ggA>ggC	p.G518G	SLCO6A1_ENST00000379807.3_Silent_p.G518G|SLCO6A1_ENST00000389019.3_Silent_p.G456G|SLCO6A1_ENST00000379810.1_Silent_p.G265G|SLCO6A1_ENST00000513675.1_Silent_p.G265G			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	518	Kazal-like.					integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		TATCATCTCTTCCACATATAG	0.313000													15	19					0	0	0.000308642	0	0
PRIMPOL	201973	broad.mit.edu	37	4	185615812	185615812	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr4:185615812A>C	ENST00000314970.6	+	14	1995	c.1562A>C	c.(1561-1563)tAt>tCt	p.Y521S	CCDC111_ENST00000515774.1_Missense_Mutation_p.Y392S|CCDC111_ENST00000510864.1_3'UTR|CCDC111_ENST00000512834.1_Missense_Mutation_p.Y520S|MLF1IP_ENST00000281453.5_3'UTR|CCDC111_ENST00000503752.1_Missense_Mutation_p.Y521S	NM_152683.2	NP_689896.1	Q96LW4	CC111_HUMAN		521					DNA replication, synthesis of RNA primer		DNA primase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|urinary_tract(2)	16		all_lung(41;9.65e-12)|Lung NSC(41;1.64e-11)|Colorectal(36;0.00531)|Hepatocellular(41;0.00932)|Renal(120;0.0246)|Prostate(90;0.0283)|all_hematologic(60;0.0749)|all_neural(102;0.131)		all cancers(43;5.84e-27)|Epithelial(43;2.2e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.28e-11)|STAD - Stomach adenocarcinoma(60;2.66e-05)|GBM - Glioblastoma multiforme(59;3.03e-05)|Colorectal(24;7.57e-05)|BRCA - Breast invasive adenocarcinoma(30;0.000249)|COAD - Colon adenocarcinoma(29;0.000502)|LUSC - Lung squamous cell carcinoma(40;0.00995)|READ - Rectum adenocarcinoma(43;0.173)		GATGATGCTTATTTTTTAGAA	0.413000													12	35					0	0	0.000978159	0	0
EPO	2056	broad.mit.edu	37	7	100320459	100320459	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr7:100320459G>A	ENST00000252723.2	+	4	600	c.419G>A	c.(418-420)gGa>gAa	p.G140E		NM_000799.2	NP_000790.2	P01588	EPO_HUMAN	erythropoietin	140				G -> R (in Ref. 1; CAA26095).	blood circulation|cellular hyperosmotic response|erythrocyte maturation|negative regulation of apoptosis|negative regulation of ion transmembrane transporter activity|negative regulation of sodium ion transport|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat5 protein|signal transduction	extracellular space	erythropoietin receptor binding|eukaryotic cell surface binding|hormone activity			central_nervous_system(2)|endometrium(2)|lung(7)|prostate(1)	12	Lung NSC(181;0.041)|all_lung(186;0.0581)				Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	CGGGCTCTGGGAGCCCAGGTG	0.577000													7	42					0	0	8.12818e-05	0	0
DNAH5	1767	broad.mit.edu	37	5	13920716	13920716	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr5:13920716C>T	ENST00000265104.4	-	6	775	c.671G>A	c.(670-672)cGa>cAa	p.R224Q		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	224	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.R224Q(2)		NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GTCACACTTTCGAAGGTTCAC	0.393000									Kartagener syndrome				46	58					0	0	0.000589545	0	0
CCDC83	220047	broad.mit.edu	37	11	85606409	85606409	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr11:85606409G>A	ENST00000280245.4	+	6	1097	c.585G>A	c.(583-585)aaG>aaA	p.K195K	CCDC83_ENST00000342404.3_Silent_p.K195K|CCDC83_ENST00000376067.1_Silent_p.K96K|CCDC83_ENST00000529676.2_3'UTR	NM_173556.3	NP_775827.2	Q8IWF9	CCD83_HUMAN	coiled-coil domain containing 83	195										breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(12)|skin(3)|upper_aerodigestive_tract(2)	29		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				TGGACCAAAAGAAGGAATGGG	0.279000													42	54					0	0	0.000781405	0	0
LRP1B	53353	broad.mit.edu	37	2	141460024	141460024	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:141460024C>T	ENST00000389484.3	-	38	7093	c.6122G>A	c.(6121-6123)tGg>tAg	p.W2041*		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2041					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GCCATTCGGCCATGCTATTCC	0.438000										TSP Lung(27;0.18)			4	16					0	0	0.000602214	0	0
ZBBX	79740	broad.mit.edu	37	3	167023529	167023529	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr3:167023529C>T	ENST00000392766.2	-	17	1967	c.1627G>A	c.(1627-1629)Gag>Aag	p.E543K	ZBBX_ENST00000307529.5_Missense_Mutation_p.E543K|ZBBX_ENST00000392767.2_Missense_Mutation_p.E543K|ZBBX_ENST00000455345.2_Missense_Mutation_p.E543K|ZBBX_ENST00000392764.1_Missense_Mutation_p.E514K	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	543						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						AATTTCTCCTCAATGGGAGCT	0.353000													16	36					0	0	0.000422831	0	0
COL4A4	1286	broad.mit.edu	37	2	227954607	227954607	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:227954607C>T	ENST00000396625.3	-	21	1643	c.1436G>A	c.(1435-1437)gGa>gAa	p.G479E	COL4A4_ENST00000329662.7_Missense_Mutation_p.G479E	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	479	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TGGGCCTCTTCCTCCTGGGGG	0.478000													5	100					0	0	0.000602214	0	0
CNTN2	6900	broad.mit.edu	37	1	205033865	205033865	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:205033865C>T	ENST00000331830.4	+	12	1790	c.1506C>T	c.(1504-1506)atC>atT	p.I502I		NM_005076.3	NP_005067.1	Q02246	CNTN2_HUMAN	contactin 2 (axonal)	502	Ig-like C2-type 5.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(11)|lung(23)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	54	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GCACTGGAATCCTATCTGTGC	0.547000													20	98					0	0	0.000229342	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140710468	140710468	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr5:140710468C>T	ENST00000517417.1	+	1	217	c.217C>T	c.(217-219)Ccg>Tcg	p.P73S	PCDHGA1_ENST00000378105.3_Missense_Mutation_p.P73S	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGTAGGATGCCGCTTTTCGC	0.587000													48	46					0	0	0.000781405	0	0
C5orf45	51149	broad.mit.edu	37	5	179268957	179268957	+	Silent	SNP	G	G	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr5:179268957G>T	ENST00000518219.1	-	5	410	c.399C>A	c.(397-399)tcC>tcA	p.S133S	C5orf45_ENST00000521333.1_Intron|C5orf45_ENST00000523267.1_Intron|C5orf45_ENST00000403396.2_Silent_p.S175S|C5orf45_ENST00000518235.1_Silent_p.S133S|C5orf45_ENST00000292586.6_Silent_p.S133S|C5orf45_ENST00000376931.2_Silent_p.S78S|C5orf45_ENST00000520698.1_Silent_p.S78S|C5orf45_ENST00000523084.1_5'UTR			Q6NTE8	CE045_HUMAN	chromosome 5 open reading frame 45	133										breast(2)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	12						CCTCCATTTTGGATGAAGGCT	0.567000													9	414					0.000442599	0.00574955	0.000442599	1	0
ICA1L	130026	broad.mit.edu	37	2	203684597	203684597	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:203684597G>A	ENST00000392237.2	-	6	542	c.385C>T	c.(385-387)Cgt>Tgt	p.R129C	ICA1L_ENST00000425178.1_Missense_Mutation_p.R129C|ICA1L_ENST00000358299.2_Missense_Mutation_p.R129C|ICA1L_ENST00000418208.1_Missense_Mutation_p.S63L	NM_138468.4	NP_612477.3	Q8NDH6	ICA1L_HUMAN	islet cell autoantigen 1,69kDa-like	129	AH.									breast(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TGCTTCAGACGAGACAGAGGA	0.423000													79	237					0	0	0.000781405	0	0
ITGB4	3691	broad.mit.edu	37	17	73745079	73745079	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr17:73745079C>T	ENST00000200181.3	+	27	3456	c.3269C>T	c.(3268-3270)gCc>gTc	p.A1090V	ITGB4_ENST00000579662.1_Missense_Mutation_p.A1090V|ITGB4_ENST00000450894.3_Missense_Mutation_p.A1090V|ITGB4_ENST00000449880.2_Missense_Mutation_p.A1090V|ITGB4_ENST00000339591.3_Missense_Mutation_p.A1090V	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	1090					cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			AAGTTTGGGGCCCACCTGGGC	0.647000													15	37					0	0	0.000566183	0	0
UFM1	51569	broad.mit.edu	37	13	38924147	38924147	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr13:38924147C>T	ENST00000239878.4	+	2	53	c.14C>T	c.(13-15)tCc>tTc	p.S5F	UFM1_ENST00000379649.1_5'UTR	NM_016617.2	NP_057701.1	P61960	UFM1_HUMAN	ubiquitin-fold modifier 1	5					protein ufmylation	cytoplasm|nucleus	protein binding			lung(2)|ovary(1)	3		Lung NSC(96;3.18e-06)|Prostate(109;0.00314)|Breast(139;0.0199)|Lung SC(185;0.0743)		all cancers(112;1.05e-08)|Epithelial(112;1.44e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000855)|BRCA - Breast invasive adenocarcinoma(63;0.00342)|GBM - Glioblastoma multiforme(144;0.0132)		TCGAAGGTTTCCTTTAAGATC	0.582000													31	26					0	0	0.000409698	0	0
GABRG2	2566	broad.mit.edu	37	5	161569262	161569262	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr5:161569262G>A	ENST00000356592.3	+	7	1322	c.862G>A	c.(862-864)Gtc>Atc	p.V288I	GABRG2_ENST00000361925.4_Missense_Mutation_p.V288I|GABRG2_ENST00000393933.4_Missense_Mutation_p.V193I|GABRG2_ENST00000414552.2_Missense_Mutation_p.V328I	NM_000816.3|NM_198904.2	NP_000807.2|NP_944494.1	P18507	GBRG2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 2	288					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(15)|lung(24)|ovary(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	62	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		ACTCATTGTCGTCCTATCCTG	0.433000													97	37					0	0	0.000781405	0	0
TSSC4	10078	broad.mit.edu	37	11	2424493	2424493	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr11:2424493G>A	ENST00000333256.6	+	3	1073	c.630G>A	c.(628-630)gaG>gaA	p.E210E	TSSC4_ENST00000380992.1_Intron|TSSC4_ENST00000380996.5_Silent_p.E146E|TSSC4_ENST00000467308.1_Intron|TSSC4_ENST00000451491.2_Silent_p.E210E			Q9Y5U2	TSSC4_HUMAN	tumor suppressing subtransferable candidate 4	210										endometrium(3)|large_intestine(1)|lung(4)	8		all_epithelial(84;0.000161)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.0137)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.00145)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCTGTGGGGAGGGGAGGGTCA	0.662000													111	182					0	0	0.000781405	0	0
COL4A2	1284	broad.mit.edu	37	13	111142067	111142067	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr13:111142067G>A	ENST00000360467.5	+	36	3587	c.3281G>A	c.(3280-3282)gGg>gAg	p.G1094E		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1094	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GGTGACATCGGGGACACTATA	0.443000													54	27					0	0	0.000781405	0	0
SYNGAP1	8831	broad.mit.edu	37	6	33403030	33403030	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr6:33403030C>T	ENST00000418600.2	+	6	712	c.611C>T	c.(610-612)tCc>tTc	p.S204F	SYNGAP1_ENST00000428982.2_Missense_Mutation_p.S145F|SYNGAP1_ENST00000496374.1_3'UTR|SYNGAP1_ENST00000293748.5_Missense_Mutation_p.S204F	NM_006772.2	NP_006763.2	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	204	PH.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(15)|ovary(7)|pancreas(1)|stomach(1)|urinary_tract(1)	43						GATGAAGATTCCATTATCAAG	0.547000													49	40					0	0	0.000781405	0	0
C7orf34	135927	broad.mit.edu	37	7	142637616	142637616	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr7:142637616G>A	ENST00000409607.3	+	2	427	c.386G>A	c.(385-387)gGa>gAa	p.G129E		NM_178829.4	NP_849151.2	Q96L11	CG034_HUMAN	chromosome 7 open reading frame 34	104						extracellular region				large_intestine(1)|lung(4)	5	Melanoma(164;0.059)					GTTTTCTCAGGAGGGCCATTG	0.542000													53	106					0	0	0.000781405	0	0
FNIP1	96459	broad.mit.edu	37	5	131039813	131039813	+	Missense_Mutation	SNP	G	G	A	rs13177318		TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr5:131039813G>A	ENST00000307968.7	-	9	976	c.977C>T	c.(976-978)tCa>tTa	p.S326L	FNIP1_ENST00000514667.1_Intron|FNIP1_ENST00000511848.1_Missense_Mutation_p.S354L|FNIP1_ENST00000510461.1_Missense_Mutation_p.S354L|FNIP1_ENST00000307954.8_Missense_Mutation_p.S309L	NM_001008738.2	NP_001008738.2			folliculin interacting protein 1											NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		AGGAAAATGTGAAAAAAAGAA	0.289000													27	18					0	0	0.000227799	0	0
ZNF518B	85460	broad.mit.edu	37	4	10445449	10445449	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr4:10445449A>G	ENST00000326756.3	-	3	2942	c.2504T>C	c.(2503-2505)aTg>aCg	p.M835T		NM_053042.2	NP_444270.2	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	835					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						ATTTGGGGACATATCTATTGG	0.458000													70	19					0	0	0.000781405	0	0
LRP1B	53353	broad.mit.edu	37	2	141460004	141460004	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:141460004C>T	ENST00000389484.3	-	38	7113	c.6142G>A	c.(6142-6144)Gac>Aac	p.D2048N		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2048					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACCTCATAGTCGATGGAGATG	0.398000										TSP Lung(27;0.18)			4	15					0	0	0.00024832	0	0
SPTBN5	51332	broad.mit.edu	37	15	42160315	42160315	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr15:42160315G>A	ENST00000320955.6	-	34	6386	c.6159C>T	c.(6157-6159)ctC>ctT	p.L2053L		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	2053					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		CTCTGAGGAAGAGCTGCTCCT	0.662000													3	8					0	0	6.4e-05	0	0
GORASP2	26003	broad.mit.edu	37	2	171819372	171819372	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:171819372C>G	ENST00000234160.4	+	9	1749	c.934C>G	c.(934-936)Ctg>Gtg	p.L312V	GORASP2_ENST00000452526.2_Missense_Mutation_p.L324V|GORASP2_ENST00000493692.1_3'UTR	NM_001201428.1|NM_015530.4	NP_001188357.1|NP_056345.3	Q9H8Y8	GORS2_HUMAN	golgi reassembly stacking protein 2, 55kDa	312	Pro-rich.					Golgi membrane				breast(3)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|skin(1)	14						ACCAGCAGGACTGCCCAACCT	0.468000													8	27					0	0	0.000673444	0	0
MAGED1	9500	broad.mit.edu	37	X	51638164	51638164	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chrX:51638164G>A	ENST00000375695.2	+	4	382	c.229G>A	c.(229-231)Gaa>Aaa	p.E77K	MAGED1_ENST00000375772.3_Missense_Mutation_p.E21K|MAGED1_ENST00000375722.1_Missense_Mutation_p.E21K|MAGED1_ENST00000326587.7_Missense_Mutation_p.E21K|MAGED1_ENST00000494718.1_3'UTR	NM_001005333.1	NP_001005333.1	Q9Y5V3	MAGD1_HUMAN	melanoma antigen family D, 1	21					apoptosis|induction of apoptosis by extracellular signals|negative regulation of epithelial cell proliferation|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|plasma membrane|protein complex	protein binding			breast(1)|endometrium(4)|large_intestine(10)|lung(13)|ovary(3)|upper_aerodigestive_tract(1)	32	Ovarian(276;0.236)					GGCCTCCGTAGAAGACAGCGC	0.592000										Multiple Myeloma(10;0.10)			15	2					0	0	0.000308642	0	0
CLEC4M	10332	broad.mit.edu	37	19	7830630	7830630	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr19:7830630C>T	ENST00000327325.5	+	4	439	c.321C>T	c.(319-321)tcC>tcT	p.S107S	CLEC4M_ENST00000357361.2_Silent_p.S107S|CLEC4M_ENST00000334806.5_Silent_p.S79S|CLEC4M_ENST00000597522.1_Silent_p.S107S|CLEC4M_ENST00000596707.1_Silent_p.S86S|CLEC4M_ENST00000248228.4_Silent_p.S107S|CLEC4M_ENST00000596363.1_Silent_p.S79S|CLEC4M_ENST00000595496.1_Silent_p.S86S|CLEC4M_ENST00000394122.2_Silent_p.S95S|CLEC4M_ENST00000359059.5_Silent_p.S86S	NM_001144909.1|NM_014257.4	NP_001138381.1|NP_055072.3	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M	107					cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(1)|skin(1)	26						CAGAGAAATCCAAGCTGCAGG	0.552000													39	45					0	0	0.000781405	0	0
DNMT3A	1788	broad.mit.edu	37	2	25467476	25467476	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:25467476G>A	ENST00000264709.3	-	14	1937	c.1600C>T	c.(1600-1602)Cag>Tag	p.Q534*	DNMT3A_ENST00000380746.4_Nonsense_Mutation_p.Q345*|DNMT3A_ENST00000402667.1_Nonsense_Mutation_p.Q311*|DNMT3A_ENST00000321117.5_Nonsense_Mutation_p.Q534*	NM_175629.2	NP_783328.1	Q9Y6K1	DNM3A_HUMAN	DNA (cytosine-5-)-methyltransferase 3 alpha	534	ADD.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(964)|kidney(3)|large_intestine(10)|lung(29)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	1021	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGTAGGACTGGTAGCCGTCG	0.597000			"""Mis, F, N, S"""		AML								8	51					0	0	0.000442599	0	0
MPHOSPH9	10198	broad.mit.edu	37	12	123645368	123645368	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr12:123645368G>A	ENST00000606320.1	-	23	3616	c.3410C>T	c.(3409-3411)tCt>tTt	p.S1137F	MPHOSPH9_ENST00000541076.2_Missense_Mutation_p.S1107F|MPHOSPH9_ENST00000302349.5_Missense_Mutation_p.S985F|MPHOSPH9_ENST00000392425.3_Missense_Mutation_p.S985F			Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	985					M phase of mitotic cell cycle	centriole|Golgi membrane				NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(18)|prostate(2)|skin(1)	33	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		TCCTCCAGGAGAAGGCATCCT	0.403000													11	29					0	0	0.00010058	0	0
SNUPN	10073	broad.mit.edu	37	15	75890955	75890955	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr15:75890955C>G	ENST00000371091.5	-	10	1405	c.953G>C	c.(952-954)tGg>tCg	p.W318S	SNUPN_ENST00000564675.1_Missense_Mutation_p.W276S|CTD-2323K18.1_ENST00000568707.1_RNA|SNUPN_ENST00000567134.1_Missense_Mutation_p.W276S|SNUPN_ENST00000308588.5_Missense_Mutation_p.W276S|SNUPN_ENST00000564644.1_Missense_Mutation_p.W276S			O95149	SPN1_HUMAN	snurportin 1	276	Necessary for binding to the m3G-cap structure.				ncRNA metabolic process|protein import into nucleus|spliceosomal snRNP assembly	cytosol|nuclear pore	protein transporter activity|RNA cap binding			endometrium(2)|large_intestine(3)|lung(2)|pancreas(1)	8						GGGGCGCAGCCAGCCCACCAA	0.557000													29	200					0	0	0.000227799	0	0
SLC3A1	6519	broad.mit.edu	37	2	44539728	44539728	+	Missense_Mutation	SNP	G	G	A	rs139377923		TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:44539728G>A	ENST00000260649.6	+	8	1412	c.1336G>A	c.(1336-1338)Ggt>Agt	p.G446S	SLC3A1_ENST00000409380.1_Missense_Mutation_p.G168S|SLC3A1_ENST00000409741.1_Missense_Mutation_p.G446S|SLC3A1_ENST00000409294.1_Missense_Mutation_p.G66S|SLC3A1_ENST00000409387.1_Missense_Mutation_p.G446S|SLC3A1_ENST00000409229.3_Missense_Mutation_p.G446S|SLC3A1_ENST00000409740.3_Missense_Mutation_p.G77S	NM_000341.3	NP_000332.2	Q07837	SLC31_HUMAN	solute carrier family 3 (amino acid transporter heavy chain), member 1	446					carbohydrate metabolic process|cellular amino acid metabolic process|ion transport	integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity|catalytic activity|cation binding|L-cystine transmembrane transporter activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(1)|skin(3)	26		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)			L-Cystine(DB00138)	CTTTCAGATTGGTGGACCAGA	0.403000													64	25					0	0	0.000781405	0	0
NLRP7	199713	broad.mit.edu	37	19	55451704	55451704	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr19:55451704C>T	ENST00000588756.1	-	6	969	c.483G>A	c.(481-483)ttG>ttA	p.L161L	NLRP7_ENST00000592784.1_Silent_p.L161L|NLRP7_ENST00000448121.2_Silent_p.L161L|NLRP7_ENST00000446217.1_Silent_p.L189L|NLRP7_ENST00000328092.5_Silent_p.L161L|NLRP7_ENST00000340844.2_Silent_p.L161L|NLRP7_ENST00000590030.1_Silent_p.L161L			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	161							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		TTCTGGGATTCAAGAATGGAA	0.507000													84	82					0	0	0.000781405	0	0
KIAA1755	85449	broad.mit.edu	37	20	36869541	36869541	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr20:36869541G>A	ENST00000279024.4	-	3	1263	c.992C>T	c.(991-993)tCc>tTc	p.S331F		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	331										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				ATTTCCCAAGGAAGGTCCTTC	0.488000													106	227					0	0	0.000781405	0	0
A3GALT2	127550	broad.mit.edu	37	1	33778437	33778437	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:33778437G>A	ENST00000442999.3	-	2	77	c.78C>T	c.(76-78)ggC>ggT	p.G26G	RP11-415J8.3_ENST00000588828.1_RNA|RP11-415J8.3_ENST00000457957.2_RNA	NM_001080438.1	NP_001073907.1			alpha 1,3-galactosyltransferase 2														Myeloproliferative disorder(586;0.0393)				ACAGAAACAGGCCTAAGAGGC	0.512000													5	16					0	0	3.59834e-05	0	0
OR51E2	81285	broad.mit.edu	37	11	4703441	4703441	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr11:4703441G>A	ENST00000396950.3	-	2	740	c.501C>T	c.(499-501)ttC>ttT	p.F167F		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		TGGAGTGGCAGAAGGCCAGCC	0.512000													17	57					0	0	0.00074312	0	0
USP44	84101	broad.mit.edu	37	12	95927253	95927253	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr12:95927253G>A	ENST00000258499.3	-	2	1068	c.780C>T	c.(778-780)tcC>tcT	p.S260S	USP44_ENST00000537435.2_Silent_p.S260S|USP44_ENST00000393091.2_Silent_p.S260S|USP44_ENST00000552440.1_Silent_p.S260S	NM_001278393.1|NM_032147.2	NP_001265322.1|NP_115523.2	Q9H0E7	UBP44_HUMAN	ubiquitin specific peptidase 44	260					anaphase|cell division|mitosis|negative regulation of mitotic anaphase-promoting complex activity|protein deubiquitination|regulation of spindle checkpoint|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(5)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	36						GTTTAACTGAGGAGTCACTGA	0.393000													26	72					0	0	0.000279167	0	0
OR5R1	219479	broad.mit.edu	37	11	56185123	56185123	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr11:56185123C>T	ENST00000312253.1	-	1	585	c.586G>A	c.(586-588)Gaa>Aaa	p.E196K		NM_001004744.1	NP_001004744.1	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R, member 1	196					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E196K(1)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(17)|ovary(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(21;0.00448)					ATCAGAATTTCCTTCATGTGT	0.433000													14	20					0	0	0.000151284	0	0
RANBP6	26953	broad.mit.edu	37	9	6013286	6013286	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr9:6013286G>A	ENST00000259569.5	-	1	2332	c.2322C>T	c.(2320-2322)ctC>ctT	p.L774L		NM_001243202.1|NM_001243203.1|NM_012416.3	NP_001230131.1|NP_001230132.1|NP_036548.1	O60518	RNBP6_HUMAN	RAN binding protein 6	774					protein transport	cytoplasm|nucleus	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(5)|large_intestine(8)|lung(9)|ovary(7)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		TTATTTCTGAGAGCACATCTG	0.413000													16	65					0	0	0.000566183	0	0
RAB11FIP3	9727	broad.mit.edu	37	16	476580	476580	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr16:476580C>T	ENST00000262305.4	+	1	962	c.574C>T	c.(574-576)Ccc>Tcc	p.P192S	RAB11FIP3_ENST00000457159.1_Missense_Mutation_p.P192S	NM_014700.3	NP_055515.1	O75154	RFIP3_HUMAN	RAB11 family interacting protein 3 (class II)	192	Pro-rich.				cell cycle|cytokinesis|endocytic recycling|protein transport	centrosome|cleavage furrow|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding			breast(1)|endometrium(2)|kidney(3)|lung(5)|upper_aerodigestive_tract(1)	12		Hepatocellular(16;0.0218)				CCAGACCCACCCCCTTCCGAG	0.731000													4	15					0	0	0.000602214	0	0
DSP	1832	broad.mit.edu	37	6	7583534	7583534	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr6:7583534G>A	ENST00000379802.3	+	24	6380	c.6039G>A	c.(6037-6039)cgG>cgA	p.R2013R	DSP_ENST00000418664.2_Silent_p.R1414R	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2013	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CATTCCTTCGGGGTGCAGGAT	0.448000													28	49					0	0	0.000720815	0	0
RNF112	7732	broad.mit.edu	37	17	19315925	19315925	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr17:19315925G>A	ENST00000461366.1	+	3	425	c.210G>A	c.(208-210)ctG>ctA	p.L70L	RNF112_ENST00000580109.1_3'UTR|CTB-187M2.2_ENST00000579897.1_RNA	NM_007148.4	NP_009079.2	Q7Z5V9	Q7Z5V9_HUMAN	ring finger protein 112	70							GTP binding|GTPase activity|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|urinary_tract(1)	12						CCATCTCGCTGGACTGTGGCC	0.652000													12	4					0	0	0.000978159	0	0
BLNK	29760	broad.mit.edu	37	10	97983740	97983740	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr10:97983740G>A	ENST00000224337.5	-	6	508	c.367C>T	c.(367-369)Cga>Tga	p.R123*	BLNK_ENST00000427367.2_Nonsense_Mutation_p.R123*|BLNK_ENST00000413476.2_Nonsense_Mutation_p.R123*|BLNK_ENST00000371176.2_Nonsense_Mutation_p.R123*	NM_013314.3	NP_037446.1	Q8WV28	BLNK_HUMAN	B-cell linker	123	Pro-rich.				B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(2)|stomach(1)	14		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		TGGCTTGATCGATTGTCTTGA	0.498000													56	55					0	0	0.000781405	0	0
VCP	7415	broad.mit.edu	37	9	35061055	35061055	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr9:35061055G>A	ENST00000358901.6	-	11	2211	c.1316C>T	c.(1315-1317)gCc>gTc	p.A439V		NM_007126.3	NP_009057.1	P55072	TERA_HUMAN	valosin containing protein	439					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			CATGACCTCGGCATCAATGGT	0.532000													34	116					0	0	0.000814825	0	0
ATP8B2	57198	broad.mit.edu	37	1	154316679	154316679	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:154316679C>T	ENST00000368489.3	+	19	2083	c.2083C>T	c.(2083-2085)Ctc>Ttc	p.L695F		NM_020452.3	NP_065185.1	P98198	AT8B2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 2	681					ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity		IL6R/ATP8B2(2)	breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GACCATTGCCCTCCTGACACT	0.537000													7	48					0	0	0.000157383	0	0
DDX39B	7919	broad.mit.edu	37	6	31500584	31500584	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr6:31500584G>A	ENST00000417556.2	-	8	1515	c.885C>T	c.(883-885)gaC>gaT	p.D295D	DDX39B_ENST00000415382.2_Silent_p.D202D|DDX39B_ENST00000376177.2_Silent_p.D280D|DDX39B_ENST00000458640.1_Silent_p.D280D|DDX39B_ENST00000396172.1_Silent_p.D280D|ATP6V1G2-DDX39B_ENST00000376185.1_3'UTR			Q13838	DX39B_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B	280	Helicase C-terminal.				intronless viral mRNA export from host nucleus|RNA secondary structure unwinding|spliceosome assembly	nuclear speck|spliceosomal complex|transcription export complex	ATP binding|ATP-dependent protein binding|ATP-dependent RNA helicase activity|identical protein binding|U4 snRNA binding|U6 snRNA binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19						CATCCAGAAGGTCAAAGAGCT	0.493000													27	66					0	0	0.00106085	0	0
MFSD6L	162387	broad.mit.edu	37	17	8702360	8702360	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr17:8702360C>T	ENST00000329805.4	-	1	307	c.79G>A	c.(79-81)Gaa>Aaa	p.E27K		NM_152599.3	NP_689812.3	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing 6-like	27						integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(7)|skin(4)	17						ACGCAGGCTTCCCGCACCCCG	0.677000													14	5					0	0	0.000566183	0	0
GAL3ST1	9514	broad.mit.edu	37	22	30953356	30953356	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr22:30953356G>A	ENST00000402321.1	-	2	341	c.24C>T	c.(22-24)ccC>ccT	p.P8P	GAL3ST1_ENST00000406361.1_Silent_p.P8P|GAL3ST1_ENST00000401975.1_Silent_p.P8P|GAL3ST1_ENST00000402369.1_Silent_p.P8P|GAL3ST1_ENST00000406955.1_Silent_p.P8P|GAL3ST1_ENST00000338911.5_Silent_p.P8P|GAL3ST1_ENST00000443111.2_Silent_p.P8P			Q99999	G3ST1_HUMAN	galactose-3-O-sulfotransferase 1	8					protein N-linked glycosylation	Golgi membrane|integral to plasma membrane|membrane fraction	galactosylceramide sulfotransferase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	21						TGGACTCCCAGGGCTTCTTCT	0.652000													52	34					0	0	0.000781405	0	0
MAMDC2	256691	broad.mit.edu	37	9	72723222	72723222	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr9:72723222C>T	ENST00000377182.4	+	3	861	c.244C>T	c.(244-246)Cgt>Tgt	p.R82C	MAMDC2-AS1_ENST00000591368.1_RNA|MAMDC2-AS1_ENST00000414515.3_RNA	NM_153267.4	NP_694999.3	Q7Z304	MAMC2_HUMAN	MAM domain containing 2	82	MAM 1.					endoplasmic reticulum|membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)	14						GAGCTGCCTCCGTTTGGTCTA	0.493000													25	6					0	0	0.000878237	0	0
BMP5	653	broad.mit.edu	37	6	55625290	55625290	+	Missense_Mutation	SNP	C	C	T	rs147691986		TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr6:55625290C>T	ENST00000370830.3	-	5	1767	c.1069G>A	c.(1069-1071)Gaa>Aaa	p.E357K	BMP5_ENST00000446683.2_Missense_Mutation_p.E357K	NM_021073.2	NP_066551.1	P22003	BMP5_HUMAN	bone morphogenetic protein 5	357					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	45	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			ACATAGAGTTCGTGCTTCTTA	0.348000													19	11					0	0	0.000175454	0	0
KRT12	3859	broad.mit.edu	37	17	39019850	39019850	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr17:39019850G>A	ENST00000251643.4	-	5	1005	c.982C>T	c.(982-984)Cgt>Tgt	p.R328C		NM_000223.3	NP_000214.1	Q99456	K1C12_HUMAN	keratin 12	328	Coil 2.|Rod.				visual perception	intermediate filament	structural molecule activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(2)	15		Breast(137;0.000301)				ATCTCCTTACGGAGCTCCCCG	0.567000													17	49					0	0	0.000422831	0	0
SEMA4F	10505	broad.mit.edu	37	2	74907289	74907289	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:74907289C>T	ENST00000357877.2	+	14	2415	c.2266C>T	c.(2266-2268)Cgg>Tgg	p.R756W	SEMA4F_ENST00000339773.5_Missense_Mutation_p.R601W	NM_004263.3	NP_004254.2	O95754	SEM4F_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F	756					cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			biliary_tract(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(2)	45						AGCCCACATTCGGCTAACTGG	0.557000													10	69					0	0	0.000978159	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58302877	58302877	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr15:58302877C>A	ENST00000249750.4	-	4	1230	c.463G>T	c.(463-465)Gat>Tat	p.D155Y	ALDH1A2_ENST00000558231.1_Missense_Mutation_p.D126Y|ALDH1A2_ENST00000559517.1_Missense_Mutation_p.D59Y|ALDH1A2_ENST00000347587.3_Missense_Mutation_p.D155Y|ALDH1A2_ENST00000537372.1_Missense_Mutation_p.D134Y	NM_003888.3	NP_003879.2	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1 family, member A2	155					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TGAATTTTATCAGCCCAGCCT	0.443000													14	51					2.61681e-11	3.46584e-10	0.000219431	1	0
AQP5	362	broad.mit.edu	37	12	50355885	50355885	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr12:50355885C>T	ENST00000293599.6	+	1	233	c.85C>T	c.(85-87)Ctg>Ttg	p.L29L	RP11-469H8.6_ENST00000552379.1_RNA|RP11-469H8.6_ENST00000550530.1_RNA|RP11-469H8.6_ENST00000550214.1_RNA	NM_001651.2	NP_001642.1	P55064	AQP5_HUMAN	aquaporin 5	29					carbon dioxide transport|excretion|odontogenesis|pancreatic juice secretion	apical plasma membrane|integral to plasma membrane	protein binding|water channel activity			large_intestine(1)|lung(3)	4						CTTCTTTGGCCTGGGCTCGGC	0.667000													12	22					0	0	0.000308642	0	0
TNNI3K	51086	broad.mit.edu	37	1	74957790	74957790	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:74957790C>T	ENST00000370891.2	+	25	2510	c.2494C>T	c.(2494-2496)Cct>Tct	p.P832S	LRRC53_ENST00000294635.4_Intron|FPGT-TNNI3K_ENST00000557284.1_Missense_Mutation_p.P832S|TNNI3K_ENST00000326637.3_Missense_Mutation_p.P731S	NM_001112808.2	NP_001106279.1			TNNI3 interacting kinase											cervix(1)|endometrium(3)|kidney(5)|large_intestine(21)|lung(31)|ovary(4)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	76						GCTGATGTCTCCTGCATCAAG	0.453000													21	175					0	0	0.000586117	0	0
LY9	4063	broad.mit.edu	37	1	160771696	160771696	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:160771696C>T	ENST00000368039.2	+	3	572	c.571C>T	c.(571-573)Cgg>Tgg	p.R191W	LY9_ENST00000368041.2_Intron|LY9_ENST00000263285.5_Intron|LY9_ENST00000341032.4_Intron|LY9_ENST00000368040.1_Intron|LY9_ENST00000471816.1_Intron	NM_001033667.2	NP_001028839.1	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	0	Ig-like C2-type 1.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			TGTGAGCGTGCGGGAGGGCTA	0.692000													21	69					0	0	0.000132079	0	0
OBSCN	84033	broad.mit.edu	37	1	228481085	228481085	+	Silent	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr1:228481085G>A	ENST00000570156.2	+	46	12260	c.12186G>A	c.(12184-12186)agG>agA	p.R4062R	OBSCN_ENST00000284548.11_Silent_p.R3633R|OBSCN_ENST00000422127.1_Silent_p.R3633R|OBSCN_ENST00000366709.4_Silent_p.R752R|OBSCN_ENST00000359599.6_Silent_p.R2480R|OBSCN_ENST00000366707.4_Silent_p.R752R	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3103	Ig-like 41.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGGGTCTGAGGAACGAAGAGG	0.542000													7	15					0	0	8.12818e-05	0	0
BTD	686	broad.mit.edu	37	3	15677086	15677086	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr3:15677086C>G	ENST00000383778.4	+	2	498	c.140C>G	c.(139-141)tCc>tGc	p.S47C	BTD_ENST00000449107.1_Missense_Mutation_p.S69C|BTD_ENST00000482824.1_3'UTR|BTD_ENST00000437172.1_Missense_Mutation_p.S69C|BTD_ENST00000303498.5_Missense_Mutation_p.S67C			P43251	BTD_HUMAN	biotinidase	67					central nervous system development|epidermis development|nitrogen compound metabolic process	extracellular space	biotin carboxylase activity|biotinidase activity			breast(2)|endometrium(3)|large_intestine(2)|lung(9)|prostate(1)|skin(1)	18						GAGCATCCATCCATCCTGAGT	0.557000													24	105					0	0	0.000586117	0	0
CACNA1G	8913	broad.mit.edu	37	17	48669190	48669190	+	Silent	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr17:48669190C>T	ENST00000352832.5	+	12	3102	c.2730C>T	c.(2728-2730)ctC>ctT	p.L910L	CACNA1G_ENST00000503485.1_Silent_p.L910L|CACNA1G_ENST00000515411.1_Silent_p.L910L|CACNA1G_ENST00000429973.2_Silent_p.L910L|CACNA1G_ENST00000514079.1_Silent_p.L910L|CACNA1G_ENST00000510366.1_Silent_p.L910L|CACNA1G_ENST00000513964.1_Silent_p.L910L|CACNA1G_ENST00000502264.1_Silent_p.L910L|CACNA1G_ENST00000505165.1_Silent_p.L910L|CACNA1G_ENST00000513689.2_Silent_p.L910L|CACNA1G_ENST00000512389.1_Silent_p.L910L|CACNA1G_ENST00000507510.2_Silent_p.L910L|CACNA1G_ENST00000514717.1_Silent_p.L910L|CACNA1G_ENST00000514181.1_Silent_p.L910L|CACNA1G_ENST00000442258.2_Silent_p.L910L|CACNA1G_ENST00000507336.1_Silent_p.L910L|CACNA1G_ENST00000359106.5_Silent_p.L910L|CACNA1G_ENST00000360761.4_Silent_p.L910L|CACNA1G_ENST00000358244.5_Silent_p.L910L|CACNA1G_ENST00000510115.1_Silent_p.L910L|CACNA1G_ENST00000515765.1_Silent_p.L910L|CACNA1G_ENST00000416767.4_Silent_p.L910L|CACNA1G_ENST00000515165.1_Silent_p.L910L|CACNA1G_ENST00000507609.1_Silent_p.L910L|CACNA1G_ENST00000354983.4_Silent_p.L910L|CACNA1G_ENST00000507896.1_Silent_p.L910L	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	910					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	ACTCCTTGCTCTGGGCCATCG	0.597000													13	54					0	0	0.000151284	0	0
DNAH7	56171	broad.mit.edu	37	2	196681368	196681368	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr2:196681368C>T	ENST00000312428.6	-	51	9845	c.9745G>A	c.(9745-9747)Gaa>Aaa	p.E3249K		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3249					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						GCCAAAATTTCTGATTTCTCT	0.328000													10	25					0	0	0.000673444	0	0
C6orf15	29113	broad.mit.edu	37	6	31079318	31079318	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr6:31079318C>T	ENST00000259870.3	-	2	821	c.818G>A	c.(817-819)gGg>gAg	p.G273E		NM_014070.2	NP_054789.2	Q6UXA7	CF015_HUMAN	chromosome 6 open reading frame 15	273	Gly-rich.									endometrium(3)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|stomach(1)	17						ATTAATATTCCCCCAGCTGCC	0.502000													32	91					0	0	0.00058488	0	0
OR52E2	119678	broad.mit.edu	37	11	5080763	5080763	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr11:5080763G>A	ENST00000321522.2	-	1	94	c.95C>T	c.(94-96)cCc>cTc	p.P32L		NM_001005164.2	NP_001005164.2	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E, member 2	32					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(13)|ovary(2)|skin(3)	20		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		AGCACAGAAGGGAAAGCCGAT	0.502000													20	14					0	0	0.000175454	0	0
GLT8D1	55830	broad.mit.edu	37	3	52731861	52731877	+	Frame_Shift_Del	DEL	CCACAGGAATCTCCTCT	CCACAGGAATCTCCTCT	-			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr3:52731861_52731877delCCACAGGAATCTCCTCT	ENST00000407584.3	-	5	1039_1055	c.189_205delAGAGGAGATTCCTGTGG	c.(187-207)catcfs	p.QEEIPVV63fs	GLT8D1_ENST00000266014.5_Frame_Shift_Del_p.QEEIPVV63fs|GLT8D1_ENST00000478968.2_Frame_Shift_Del_p.QEEIPVV63fs|GLT8D1_ENST00000491606.1_Frame_Shift_Del_p.QEEIPVV63fs|GLT8D1_ENST00000394783.3_Frame_Shift_Del_p.QEEIPVV63fs	NM_001010983.1|NM_001278280.1	NP_001010983.1|NP_001265209.1	Q68CQ7	GL8D1_HUMAN	glycosyltransferase 8 domain containing 1	63						integral to membrane|mitochondrion	transferase activity, transferring glycosyl groups			breast(1)|endometrium(1)|kidney(3)|large_intestine(3)	8				BRCA - Breast invasive adenocarcinoma(193;6.78e-05)|Kidney(197;0.000618)|KIRC - Kidney renal clear cell carcinoma(197;0.000779)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GCAGCGATGACCACAGGAATCTCCTCTTGTCTCCCAT	0.470													14	62	---	---	---	---					
C6orf223	221416	broad.mit.edu	37	6	43970504	43970509	+	In_Frame_Del	DEL	GCGGCG	GCGGCG	-	rs72369323		TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr6:43970504_43970509delGCGGCG	ENST00000336600.5	+	4	390_395	c.370_375delGCGGCG	c.(370-375)del	p.AA130del	C6orf223_ENST00000439969.2_3'UTR|C6orf223_ENST00000448947.2_3'UTR|RP5-1120P11.1_ENST00000422059.1_RNA|RP5-1120P11.1_ENST00000607590.1_RNA	NM_001171992.1|NM_153246.4	NP_001165463.1|NP_694978.2	Q8N319	CF223_HUMAN	chromosome 6 open reading frame 223	130	Ala-rich.									central_nervous_system(1)|lung(2)|pancreas(1)|prostate(1)|urinary_tract(1)	6	all_cancers(18;2.28e-07)|all_epithelial(2;1.62e-08)|Lung NSC(15;0.000172)|all_lung(25;0.000533)|Hepatocellular(11;0.00309)|Ovarian(13;0.0437)		all cancers(41;0.00141)|Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.217)			GGTAGAGCGCgcggcggcggcggcgg	0.772													5	11	---	---	---	---					
GTF2IRD1P1	729156	broad.mit.edu	37	7	66304731	66304731	+	RNA	DEL	T	T	-			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr7:66304731delT	ENST00000457166.1	-	0	189					NR_003934.1																						TTTCTTTCCCttttttttttt	0.512													4	3	---	---	---	---					
NFIB	4781	broad.mit.edu	37	9	14146714	14146714	+	Frame_Shift_Del	DEL	C	C	-	rs144909299		TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr9:14146714delC	ENST00000380959.3	-	6	1372	c.899delG	c.(898-900)atfs	p.S300fs	NFIB_ENST00000380953.1_Frame_Shift_Del_p.S300fs|NFIB_ENST00000397581.2_Frame_Shift_Del_p.S300fs|NFIB_ENST00000380924.1_Frame_Shift_Del_p.S48fs|NFIB_ENST00000397575.3_Frame_Shift_Del_p.S300fs|NFIB_ENST00000380934.4_Frame_Shift_Del_p.S326fs|NFIB_ENST00000543693.1_Frame_Shift_Del_p.S48fs|NFIB_ENST00000397579.2_Frame_Shift_Del_p.S300fs	NM_005596.3	NP_005587.2	O00712	NFIB_HUMAN	nuclear factor I/B	300					anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity			central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)		CCATGTTCGACTTCCAGCAGC	0.413			T	"""MYB, HGMA2"""	"""adenoid cystic carcinoma, lipoma"""								18	32	---	---	---	---					
LOC403323	403323	broad.mit.edu	37	9	66545695	66545695	+	RNA	DEL	A	A	-			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr9:66545695delA	ENST00000445604.2	-	0	669																											CTGTAAGAGGAAAAAAAAACA	0.373													4	2	---	---	---	---					
TRPM6	140803	broad.mit.edu	37	9	77455061	77455062	+	Frame_Shift_Del	DEL	TG	TG	-	rs121912625		TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr9:77455061_77455062delTG	ENST00000451710.3	-	5	659_660	c.422_423delCA	c.(421-423)tfs	p.S141fs	TRPM6_ENST00000376872.3_Frame_Shift_Del_p.S141fs|TRPM6_ENST00000449912.2_Frame_Shift_Del_p.S136fs|TRPM6_ENST00000376864.4_Frame_Shift_Del_p.S141fs|TRPM6_ENST00000376871.3_Frame_Shift_Del_p.S141fs|TRPM6_ENST00000361255.3_Frame_Shift_Del_p.S136fs|TRPM6_ENST00000360774.1_Frame_Shift_Del_p.S141fs|TRPM6_ENST00000359047.2_Frame_Shift_Del_p.S141fs			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	141			S -> L (in HOMG1; impairs heterodimer formation resulting in intracellular retention).		response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						CCCCATGGACTGAGATCACAAG	0.391													11	22	---	---	---	---					
PRPF40B	25766	broad.mit.edu	37	12	50025257	50025258	+	Frame_Shift_Ins	INS	-	-	C			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr12:50025257_50025258insC	ENST00000261897.1	+	2	625_626	c.74_75insC	c.(73-75)accfs	p.T25fs	PRPF40B_ENST00000548825.2_Frame_Shift_Ins_p.T53fs|PRPF40B_ENST00000380281.1_Frame_Shift_Ins_p.T31fs			Q6NWY9	PR40B_HUMAN	PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)	31	Pro-rich.				mRNA processing|RNA splicing	nuclear speck				breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	34						CCACCAGCTATCCCCCCCATGC	0.604													18	72	---	---	---	---					
BLM	641	broad.mit.edu	37	15	91304286	91304288	+	In_Frame_Del	DEL	TGA	TGA	-			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr15:91304286_91304288delTGA	ENST00000355112.3	+	7	1801_1803	c.1683_1685delTGA	c.(1681-1686)ttt>tt	p.FD561del	BLM_ENST00000560509.1_In_Frame_Del_p.FD561del	NM_000057.2	NP_000048.1	P54132	BLM_HUMAN	Bloom syndrome, RecQ helicase-like	561	Poly-Asp.				double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(11)|liver(4)|lung(9)|ovary(6)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			TAGATGACTTTGATGATGATGAT	0.374			"""Mis, N, F"""			"""leukemia, lymphoma, skin squamous cell , other cancers"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Bloom syndrome				7	968	---	---	---	---					
LRRK1	79705	broad.mit.edu	37	15	101562697	101562697	+	Frame_Shift_Del	DEL	C	C	-			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr15:101562697delC	ENST00000284395.5	+	16	2353	c.1953delC	c.(1951-1953)ctfs	p.L652fs	LRRK1_ENST00000388948.3_Frame_Shift_Del_p.L655fs			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	655	Roc.				small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			AGTCCACCCTCCTGGAGATCT	0.622													15	91	---	---	---	---					
HIPK4	147746	broad.mit.edu	37	19	40886647	40886649	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr19:40886647_40886649delCTC	ENST00000291823.2	-	3	1533_1535	c.1249_1251delGAG	c.(1249-1251)del	p.E417del		NM_144685.3	NP_653286.2	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	417						cytoplasm	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	20			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			CTGGTGCCTTCTCCTCTCGGAAG	0.626													17	57	---	---	---	---					
IGLV3-12	28802	broad.mit.edu	37	22	23114749	23114749	+	RNA	DEL	T	T	-	rs74864698		TCGA-D9-A148-06A-11D-A19A-08	TCGA-D9-A148-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7e884b1-ab8a-4225-9fc9-a2a6fd8f4660	b036b9bb-f047-427a-bd1f-7bdec7c15002	g.chr22:23114749delT	ENST00000390313.2	+	0	55																											CATCCTCTCCTTTTTTTTTTT	0.498													4	7	---	---	---	---					
