Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
OR10S1	219873	broad.mit.edu	37	11	123848231	123848231	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:123848231G>A	ENST00000531945.1	-	1	257	c.168C>T	c.(166-168)ctC>ctT	p.L56L		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	56					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GGAGGATGAGGAGATTCCCAG	0.527000													6	8					0	0	1	0	0
CD1B	910	broad.mit.edu	37	1	158299826	158299826	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:158299826G>A	ENST00000368168.3	-	3	530	c.423C>T	c.(421-423)ttC>ttT	p.F141F		NM_001764.2	NP_001755.1	P29016	CD1B_HUMAN	CD1b molecule	141					antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding	p.F141F(1)		breast(2)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	30	all_hematologic(112;0.0378)					TGACACTCAGGAAATCCAATC	0.483000													52	83					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220315923	220315923	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:220315923C>T	ENST00000312358.7	+	5	2311	c.2179C>T	c.(2179-2181)Ccc>Tcc	p.P727S	SPEG_ENST00000396695.2_5'UTR|SPEG_ENST00000485813.1_3'UTR|SPEG_ENST00000396698.1_Missense_Mutation_p.P623S	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	727	Ig-like 2.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GTTTGAGATCCCCCTGCAGAA	0.602000													33	57					0	0	1	0	0
TRPM7	54822	broad.mit.edu	37	15	50926685	50926685	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:50926685G>A	ENST00000313478.7	-	8	1182	c.901C>T	c.(901-903)Ctt>Ttt	p.L301F	TRPM7_ENST00000560955.1_Missense_Mutation_p.L301F	NM_017672.4	NP_060142.3	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel, subfamily M, member 7	301					cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(17)|lung(13)|ovary(4)|pancreas(1)|skin(4)|stomach(3)	52				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		AGGTATTCAAGAACTGTGAGG	0.428000													6	25					0	0	1	0	0
ABCC1	4363	broad.mit.edu	37	16	16232340	16232340	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr16:16232340C>T	ENST00000399408.2	+	31	4617	c.4442C>T	c.(4441-4443)aCc>aTc	p.T1481I	ABCC1_ENST00000346370.5_Missense_Mutation_p.T1415I|ABCC1_ENST00000351154.5_Missense_Mutation_p.T1412I|ABCC1_ENST00000349029.5_Missense_Mutation_p.T1356I|ABCC1_ENST00000399410.3_Missense_Mutation_p.T1471I|ABCC1_ENST00000345148.5_Intron			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	1471	ABC transporter 2.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	ATCCAGTCCACCATCCGGACA	0.612000													11	11					0	0	1	0	0
ZNF585A	199704	broad.mit.edu	37	19	37643951	37643951	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:37643951G>A	ENST00000356958.4	-	5	1108	c.850C>T	c.(850-852)Cat>Tat	p.H284Y	ZNF585A_ENST00000355533.2_Missense_Mutation_p.H229Y|ZNF585A_ENST00000588723.1_Intron|ZNF585A_ENST00000292841.5_Missense_Mutation_p.H229Y|ZNF585A_ENST00000392157.2_Missense_Mutation_p.H229Y			Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	284					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(2)|large_intestine(17)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GCAATCAAATGGGTCTTCTGG	0.423000													113	73					0	0	1	0	0
PICALM	8301	broad.mit.edu	37	11	85711762	85711762	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:85711762G>A	ENST00000526033.1	-	11	1394	c.1078C>T	c.(1078-1080)Cct>Tct	p.P360S	PICALM_ENST00000532317.1_Missense_Mutation_p.P360S|PICALM_ENST00000528398.1_Missense_Mutation_p.P309S|PICALM_ENST00000393346.3_Missense_Mutation_p.P360S|PICALM_ENST00000356360.5_Missense_Mutation_p.P360S	NM_001206946.1|NM_007166.3	NP_001193875.1|NP_009097.2	Q13492	PICAL_HUMAN	phosphatidylinositol binding clathrin assembly protein	360					clathrin coat assembly|endosome transport|negative regulation of receptor-mediated endocytosis|positive regulation of transcription, DNA-dependent|receptor internalization|regulation of protein localization	clathrin coat|clathrin-coated vesicle|coated pit|Golgi apparatus|nucleus|postsynaptic membrane|presynaptic membrane	1-phosphatidylinositol binding|clathrin heavy chain binding			endometrium(1)|kidney(2)|large_intestine(2)|liver(1)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	19		Acute lymphoblastic leukemia(157;7.42e-07)|all_hematologic(158;0.00092)				GTGGATACAGGAGAGGCTGCA	0.438000			T	"""MLLT10, MLL"""	"""TALL, AML, """								24	29					0	0	1	0	0
OR5P3	120066	broad.mit.edu	37	11	7846635	7846635	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:7846635C>T	ENST00000328375.1	-	1	884	c.885G>A	c.(883-885)aaG>aaA	p.K295K	RP11-35J10.5_ENST00000527565.1_lincRNA	NM_153445.1	NP_703146.1	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P, member 3	295					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	15				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CCTTAATCTCCTTGTTCCTGA	0.393000													12	21					0	0	1	0	0
RDH8	50700	broad.mit.edu	37	19	10131441	10131441	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:10131441G>A	ENST00000591589.1	+	4	748	c.559G>A	c.(559-561)Gaa>Aaa	p.E187K	RDH8_ENST00000171214.1_Missense_Mutation_p.E167K			Q9NYR8	RDH8_HUMAN	retinol dehydrogenase 8 (all-trans)	167					estrogen biosynthetic process|response to stimulus|visual perception	cytoplasm|integral to plasma membrane	binding|estradiol 17-beta-dehydrogenase activity|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			endometrium(3)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|prostate(1)	21			Epithelial(33;4.24e-05)		Vitamin A(DB00162)	GGGATTCTTCGAAAGCCTCGC	0.582000													11	15					0	0	1	0	0
IGFN1	91156	broad.mit.edu	37	1	201191880	201191880	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:201191880C>T	ENST00000335211.4	+	20	10345	c.10215C>T	c.(10213-10215)ttC>ttT	p.F3405F	IGFN1_ENST00000295591.8_Silent_p.F565F|RP11-567E21.3_ENST00000453155.1_RNA	NM_001164586.1	NP_001158058.1			immunoglobulin-like and fibronectin type III domain containing 1											autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						GTCCCAAGTTCCTCGTGGACT	0.602000											OREG0014073	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	20					0	0	1	0	0
AQR	9716	broad.mit.edu	37	15	35261781	35261781	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:35261781C>T	ENST00000156471.5	-	1	259	c.34G>A	c.(34-36)Gcc>Acc	p.A12T		NM_014691.2	NP_055506.1	O60306	AQR_HUMAN	aquarius intron-binding spliceosomal factor	12						catalytic step 2 spliceosome	RNA binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(10)|lung(18)|ovary(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	57		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		ACCGTAGGGGCCACGATCTTC	0.632000											OREG0023038	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	10					0	0	1	0	0
IGLV3-27	28791	broad.mit.edu	37	22	23011165	23011165	+	RNA	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr22:23011165C>T	ENST00000390304.2	+	0	266																											CCTCAGGGATCCCTGAGCGAT	0.562000													10	19					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16875888	16875888	+	Missense_Mutation	SNP	T	T	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:16875888T>G	ENST00000524140.2	+	10	2713	c.2295T>G	c.(2293-2295)atT>atG	p.I765M	NWD1_ENST00000379808.3_Missense_Mutation_p.I765M|NWD1_ENST00000339803.6_Missense_Mutation_p.I630M|NWD1_ENST00000552788.1_Missense_Mutation_p.I765M|NWD1_ENST00000549814.1_Missense_Mutation_p.I765M|NWD1_ENST00000523826.1_Missense_Mutation_p.I559M	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	765							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CTGGGGGCATTGAAGACCTGC	0.622000													29	45					0	0	1	0	0
SETD7	80854	broad.mit.edu	37	4	140432999	140432999	+	Splice_Site	SNP	T	T	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:140432999T>C	ENST00000274031.3	-	8	1557		c.e8-2		SETD7_ENST00000506866.2_Intron	NM_030648.2	NP_085151.1	Q8WTS6	SETD7_HUMAN	SET domain containing (lysine methyltransferase) 7						peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	histone-lysine N-methyltransferase activity|p53 binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	8	all_hematologic(180;0.156)					TGGACAAACCTAAACATCAAG	0.567000													20	24					0	0	1	0	0
HMGCR	3156	broad.mit.edu	37	5	74646089	74646089	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:74646089C>G	ENST00000287936.4	+	8	826	c.670C>G	c.(670-672)Cgg>Ggg	p.R224G	HMGCR_ENST00000343975.5_Missense_Mutation_p.R224G|HMGCR_ENST00000511206.1_Missense_Mutation_p.R224G	NM_000859.2	NP_000850.1	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-CoA reductase	224					cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	20		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	GTAGCTTTCTCGGGAAAGCCG	0.418000													7	12					0	0	1	0	0
INTS8	55656	broad.mit.edu	37	8	95869014	95869014	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:95869014C>T	ENST00000523731.1	+	15	1895	c.1762C>T	c.(1762-1764)Cat>Tat	p.H588Y	INTS8_ENST00000520845.1_3'UTR|INTS8_ENST00000447247.1_Missense_Mutation_p.H588Y	NM_017864.2	NP_060334.2	Q75QN2	INT8_HUMAN	integrator complex subunit 8	588					snRNA processing	integrator complex	protein binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	28	Breast(36;1.05e-06)					GGACTTTTCCCATGCTAAACA	0.428000													42	91					0	0	1	0	0
RIN3	79890	broad.mit.edu	37	14	93154522	93154522	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:93154522G>A	ENST00000216487.7	+	10	3042	c.2883G>A	c.(2881-2883)cgG>cgA	p.R961R	RIN3_ENST00000418924.2_3'UTR	NM_024832.3	NP_079108.3	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	961	Ras-associating.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			endometrium(4)|kidney(2)|large_intestine(7)|lung(19)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	36		all_cancers(154;0.0701)				TTGTCTACCGGCCCCTGGACG	0.731000													5	6					0	0	1	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19666685	19666685	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr21:19666685C>T	ENST00000284885.3	-	21	2421	c.2388G>A	c.(2386-2388)tgG>tgA	p.W796*		NM_002772.2	NP_002763.2	P98073	ENTK_HUMAN	transmembrane protease, serine 15	796	Peptidase S1.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						CAACCCAGGGCCAGGCCCCTT	0.527000													42	41					0	0	1	0	0
FSCB	84075	broad.mit.edu	37	14	44975202	44975202	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:44975202G>A	ENST00000340446.4	-	1	1280	c.989C>T	c.(988-990)cCt>cTt	p.P330L		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	330	Pro-rich.					cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		AATTTCAGCAGGAAACTCCAC	0.512000													14	27					0	0	1	0	0
NOVA1	4857	broad.mit.edu	37	14	26949289	26949289	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:26949289C>T	ENST00000539517.2	-	3	658	c.341G>A	c.(340-342)gGa>gAa	p.G114E	NOVA1_ENST00000267422.7_5'UTR|NOVA1_ENST00000574031.1_Missense_Mutation_p.G114E|NOVA1_ENST00000465357.2_Missense_Mutation_p.G114E|NOVA1_ENST00000547619.1_Missense_Mutation_p.G114E|NOVA1_ENST00000344429.5_Missense_Mutation_p.G114E	NM_002515.2	NP_002506.2	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1	117	KH 1.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(265;0.0135)		TGCAATGAATCCATGAACTGC	0.438000													22	33					0	0	1	0	0
LIX1	167410	broad.mit.edu	37	5	96443145	96443145	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:96443145G>A	ENST00000274382.4	-	3	601	c.306C>T	c.(304-306)tcC>tcT	p.S102S	CTD-2215E18.1_ENST00000509481.1_Intron	NM_153234.4	NP_694966.3	Q8N485	LIX1_HUMAN	Lix1 homolog (chicken)	102										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(2)|ovary(1)	10		all_cancers(142;4.28e-07)|all_epithelial(76;1.06e-09)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0318)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.0733)		CATTGAAGAGGGAGTTGATCA	0.517000													15	30					0	0	1	0	0
MASP2	10747	broad.mit.edu	37	1	11105495	11105495	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:11105495C>T	ENST00000400897.3	-	4	529	c.514G>A	c.(514-516)Gtc>Atc	p.V172I	MASP2_ENST00000400898.3_Missense_Mutation_p.V172I	NM_006610.3	NP_006601.2	O00187	MASP2_HUMAN	mannan-binding lectin serine peptidase 2	172	EGF-like; calcium-binding.				complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			biliary_tract(1)|endometrium(2)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		CGGTGCAGGACGTAGCCTGCG	0.677000													3	21					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18793653	18793653	+	Splice_Site	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:18793653C>T	ENST00000440756.2	-	2	124		c.e2-1		PSD3_ENST00000520789.1_Splice_Site|PSD3_ENST00000327040.8_Splice_Site			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3						regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		ATGTCTCTGCCTGCAAAATAA	0.333000													31	41					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43912676	43912676	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:43912676C>T	ENST00000562955.1	+	65	8952	c.8952C>T	c.(8950-8952)caC>caT	p.H2984H	SZT2_ENST00000372442.1_Silent_p.H2142H	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	3041						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						ACCTGATGCACGTGCACTCGT	0.597000													8	8					0	0	1	0	0
GDF5	8200	broad.mit.edu	37	20	34025333	34025333	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:34025333C>T	ENST00000374372.1	-	3	879	c.376G>A	c.(376-378)Gga>Aga	p.G126R	GDF5_ENST00000374369.3_Missense_Mutation_p.G126R			P43026	GDF5_HUMAN	growth differentiation factor 5	126					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(9)|skin(3)	26	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			GGAAGCTGTCCTTTTGGGGTC	0.647000													28	46					0	0	1	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77913210	77913210	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:77913210G>A	ENST00000321110.1	-	2	1003	c.708C>T	c.(706-708)ttC>ttT	p.F236F		NM_152694.2	NP_689907.1	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	236							nucleic acid binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)|prostate(1)|skin(1)	37						ATTGCAGGGGGAAATCTGTAG	0.502000													3	2					0	0	1	0	0
FCRL1	115350	broad.mit.edu	37	1	157771884	157771884	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:157771884G>A	ENST00000358292.3	-	5	758	c.707C>T	c.(706-708)cCt>cTt	p.P236L	FCRL1_ENST00000368176.3_Missense_Mutation_p.P236L|FCRL1_ENST00000489998.1_5'UTR|FCRL1_ENST00000491942.1_Missense_Mutation_p.P236L	NM_001159397.1	NP_001152869.1	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1	236	Ig-like C2-type 3.					integral to membrane|plasma membrane	receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(24)|ovary(4)|prostate(1)|skin(6)	42	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CAGGATCGGAGGAGAGCCTCT	0.607000													15	24					0	0	1	0	0
SMOC2	64094	broad.mit.edu	37	6	168999536	168999536	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:168999536G>A	ENST00000354536.5	+	8	929	c.709G>A	c.(709-711)Gaa>Aaa	p.E237K	SMOC2_ENST00000356284.2_Missense_Mutation_p.E226K	NM_022138.2	NP_071421.1	Q9H3U7	SMOC2_HUMAN	SPARC related modular calcium binding 2	226	Thyroglobulin type-1 2.				signal transduction	basement membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	32		Breast(66;0.000141)|Esophageal squamous(34;0.222)|Ovarian(120;0.231)		OV - Ovarian serous cystadenocarcinoma(33;1.31e-19)|BRCA - Breast invasive adenocarcinoma(81;3.06e-06)|GBM - Glioblastoma multiforme(31;0.00109)		TGCCCTGGAGGAAGCCAAGCA	0.607000													25	45					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41201724	41201724	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:41201724G>A	ENST00000263413.3	-	3	500	c.236C>T	c.(235-237)cCc>cTc	p.P79L	C6_ENST00000337836.5_Missense_Mutation_p.P79L	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	79	TSP type-1 1.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				GCAGTTGATGGGGCATCTTTG	0.433000													18	21					0	0	1	0	0
TBC1D9	23158	broad.mit.edu	37	4	141622683	141622683	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:141622683G>A	ENST00000442267.2	-	2	290	c.216C>T	c.(214-216)tcC>tcT	p.S72S		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	72						intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				AGTAGACCAGGGAGTCTGGAG	0.498000													7	13					0	0	1	0	0
GP6	51206	broad.mit.edu	37	19	55526069	55526069	+	Missense_Mutation	SNP	C	C	T	rs150807394	by1000genomes	TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:55526069C>T	ENST00000310373.3	-	8	1271	c.1244G>A	c.(1243-1245)gGa>gAa	p.G415E	CTC-550B14.7_ENST00000586845.1_RNA|GP6_ENST00000333884.2_3'UTR|GP6_ENST00000417454.1_3'UTR|CTC-550B14.7_ENST00000593060.1_RNA	NM_001083899.1	NP_001077368.1	Q9HCN6	GPVI_HUMAN	glycoprotein VI (platelet)	33					enzyme linked receptor protein signaling pathway|leukocyte migration|platelet activation	integral to plasma membrane	collagen binding|transmembrane receptor activity			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19			BRCA - Breast invasive adenocarcinoma(297;0.156)	GBM - Glioblastoma multiforme(193;0.0515)		CAGATTCCTTCCATCCCAAAT	0.567000													32	22					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10100179	10100179	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:10100179C>T	ENST00000264828.3	-	25	2097	c.2012G>A	c.(2011-2013)gGa>gAa	p.G671E		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	671	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GCCTGGAATTCCTGGGTTTCC	0.567000													13	25					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52321401	52321401	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:52321401G>A	ENST00000356297.4	-	17	2883	c.2783C>T	c.(2782-2784)cCc>cTc	p.P928L	PXDNL_ENST00000543296.1_Missense_Mutation_p.P928L	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	928					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CTTTCCGGAGGGAGGCCAAGG	0.647000													14	19					0	0	1	0	0
GRM1	2911	broad.mit.edu	37	6	146480582	146480582	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:146480582G>A	ENST00000392299.2	+	3	1269	c.799G>A	c.(799-801)Gag>Aag	p.E267K	GRM1_ENST00000355289.4_Missense_Mutation_p.E267K|GRM1_ENST00000492807.2_Missense_Mutation_p.E267K|GRM1_ENST00000361719.2_Missense_Mutation_p.E267K|GRM1_ENST00000507907.1_Missense_Mutation_p.E267K|GRM1_ENST00000282753.1_Missense_Mutation_p.E267K			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	267					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CAACGCTGGGGAGAAGAGCTT	0.547000													21	24					0	0	1	0	0
TRIM42	287015	broad.mit.edu	37	3	140407044	140407044	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:140407044C>T	ENST00000286349.3	+	3	1711	c.1520C>T	c.(1519-1521)cCc>cTc	p.P507L		NM_152616.4	NP_689829.3	Q8IWZ5	TRI42_HUMAN	tripartite motif containing 42	507						intracellular	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(11)|lung(33)|ovary(2)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						CTGCCCTCCCCCTACCCCGTG	0.572000													17	32					0	0	1	0	0
EMILIN2	84034	broad.mit.edu	37	18	2885091	2885091	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr18:2885091C>T	ENST00000254528.3	+	3	546	c.387C>T	c.(385-387)ctC>ctT	p.L129L		NM_032048.2	NP_114437.2	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2	129					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(4)	48				READ - Rectum adenocarcinoma(2;0.1)		TGAAGACCCTCCGCCCCACGC	0.512000													11	28					0	0	1	0	0
PCDHGA11	56105	broad.mit.edu	37	5	140803045	140803045	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:140803045C>T	ENST00000398587.2	+	1	2284	c.2251C>T	c.(2251-2253)Ctg>Ttg	p.L751L	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018914.2|NM_032092.1	NP_061737.1|NP_114481.1														breast(3)|endometrium(8)|kidney(3)|large_intestine(9)|lung(22)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAGGCTTTCCTGCAAACCTA	0.577000													24	42					0	0	1	0	0
MRPL39	54148	broad.mit.edu	37	21	26976125	26976125	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr21:26976125G>A	ENST00000307301.7	-	3	444	c.403C>T	c.(403-405)Cca>Tca	p.P135S	MRPL39_ENST00000352957.4_Missense_Mutation_p.P135S	NM_080794.3	NP_542984.2	Q9NYK5	RM39_HUMAN	mitochondrial ribosomal protein L39	135						mitochondrial ribosome	nucleotide binding			endometrium(2)|large_intestine(3)|lung(4)|ovary(1)	10						ACTTCTCCTGGATCACAATCT	0.368000													10	13					0	0	1	0	0
OR51I2	390064	broad.mit.edu	37	11	5475183	5475183	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:5475183C>T	ENST00000341449.2	+	1	546	c.465C>T	c.(463-465)acC>acT	p.T155T	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron|HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron	NM_001004754.2	NP_001004754.1	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I, member 2	155					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCTTCATCACCCTTTTCCCTC	0.502000													20	37					0	0	1	0	0
SPPL2C	162540	broad.mit.edu	37	17	43922587	43922587	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:43922587G>A	ENST00000329196.5	+	1	332	c.315G>A	c.(313-315)acG>acA	p.T105T	MAPT-AS1_ENST00000579599.1_RNA|MAPT-AS1_ENST00000579244.1_RNA	NM_175882.2	NP_787078.2	Q8IUH8	IMP5_HUMAN	signal peptide peptidase like 2C	105						integral to membrane	aspartic-type endopeptidase activity										GCTTCCACACGAAAGGCTGGC	0.667000													12	16					0	0	1	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36226038	36226038	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:36226038G>T	ENST00000258840.6	-	7	1014	c.624C>A	c.(622-624)agC>agA	p.S208R	RALGAPA1_ENST00000389698.3_Missense_Mutation_p.S208R|RALGAPA1_ENST00000382366.3_Missense_Mutation_p.S208R|RALGAPA1_ENST00000554704.1_5'UTR|RALGAPA1_ENST00000307138.6_Missense_Mutation_p.S208R			Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1 (catalytic)	208					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(7)|large_intestine(14)|lung(21)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CAAGAAAATAGCTTGTGAGAT	0.378000													19	38					2.4624e-09	2.49696e-09	1	1	0
SORCS3	22986	broad.mit.edu	37	10	106970971	106970971	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:106970971G>A	ENST00000369701.3	+	17	2565	c.2338G>A	c.(2338-2340)Gac>Aac	p.D780N	SORCS3_ENST00000369699.4_Missense_Mutation_p.D66N	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	780						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CCCATCAAAGGACTGCAGCCT	0.463000													10	12					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	41100957	41100957	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:41100957G>A	ENST00000373198.3	-	8	1634	c.1399C>T	c.(1399-1401)Ccc>Tcc	p.P467S	PTPRT_ENST00000373187.1_Missense_Mutation_p.P467S|PTPRT_ENST00000373193.3_Missense_Mutation_p.P467S|PTPRT_ENST00000373201.1_Missense_Mutation_p.P467S|PTPRT_ENST00000356100.2_Missense_Mutation_p.P467S|PTPRT_ENST00000373184.1_Missense_Mutation_p.P467S|PTPRT_ENST00000373190.1_Missense_Mutation_p.P467S	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	467	Fibronectin type-III 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CGGCCCTCGGGGTTAGACAGC	0.592000													17	20					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73065184	73065184	+	RNA	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:73065184G>A	ENST00000429829.1	-	0	7404					NR_001564.2																						TGCAAAAAGGGTCTGAGAGTA	0.468000													38	17					0	0	1	0	0
IRAK2	3656	broad.mit.edu	37	3	10261383	10261383	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:10261383C>T	ENST00000256458.4	+	8	1013	c.923C>T	c.(922-924)cCc>cTc	p.P308L		NM_001570.3	NP_001561.3	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	308	Protein kinase.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			breast(4)|large_intestine(8)|lung(11)|prostate(1)|stomach(1)	25						GACCCCCTCCCCTGGCCCCAG	0.562000													6	11					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1257344	1257344	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr16:1257344C>T	ENST00000348261.5	+	14	3225	c.2977C>T	c.(2977-2979)Ctc>Ttc	p.L993F	CACNA1H_ENST00000565831.1_Missense_Mutation_p.L993F|CACNA1H_ENST00000358590.4_Missense_Mutation_p.L993F	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	993					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CTGGGCCGCCCTCTACTTCGT	0.647000													5	10					0	0	1	0	0
SPOCD1	90853	broad.mit.edu	37	1	32259367	32259367	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:32259367G>A	ENST00000360482.2	-	12	2644	c.2515C>T	c.(2515-2517)Ccc>Tcc	p.P839S	SPOCD1_ENST00000373648.2_3'UTR|SPOCD1_ENST00000257100.3_Missense_Mutation_p.P332S|SPOCD1_ENST00000533231.1_Missense_Mutation_p.P839S	NM_144569.4	NP_653170.3	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	839					transcription, DNA-dependent					NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(1)|lung(7)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	37		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		GGTTCCGTGGGAGACAACTCC	0.582000													36	47					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57829072	57829072	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:57829072C>T	ENST00000371030.2	+	5	4308	c.4308C>T	c.(4306-4308)ccC>ccT	p.P1436P		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1436						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					TGCCTCTACCCCCTGGCAAAG	0.527000													18	28					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55541048	55541048	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:55541048C>A	ENST00000220676.1	+	4	4754	c.4606C>A	c.(4606-4608)Cca>Aca	p.P1536T		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1536					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GGCAACACCACCATCTTTAGA	0.313000													12	24					6.40141e-05	6.44041e-05	1	1	0
KIF13B	23303	broad.mit.edu	37	8	28928132	28928132	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:28928132C>T	ENST00000524189.1	-	40	5408	c.5370G>A	c.(5368-5370)cgG>cgA	p.R1790R	KIF13B_ENST00000404075.3_Silent_p.R309R	NM_015254.3	NP_056069.2	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	1790					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding			endometrium(6)|kidney(1)|lung(20)|urinary_tract(1)	28		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		GGGTGGCGCTCCGGCGGGCCT	0.731000													3	2					0	0	1	0	0
NCF1	653361	broad.mit.edu	37	7	74197917	74197917	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:74197917C>T	ENST00000289473.4	+	7	694	c.624C>T	c.(622-624)tcC>tcT	p.S208S	NCF1_ENST00000443956.3_3'UTR	NM_000265.4	NP_000256.3	P14598	NCF1_HUMAN	neutrophil cytosolic factor 1	208	SH3 1.				cell communication|cellular defense response|innate immune response|protein targeting to membrane|respiratory burst|superoxide anion generation	cytosol|NADPH oxidase complex|soluble fraction	electron carrier activity|GTP binding|GTPase activity|phosphatidylinositol binding|SH3 domain binding|superoxide-generating NADPH oxidase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|skin(3)	10						TCCCAGCGTCCTTCCTCGAGC	0.637000													9	30					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47855922	47855922	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr21:47855922C>T	ENST00000359568.5	+	39	8964	c.8857C>T	c.(8857-8859)Cac>Tac	p.H2953Y	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	2953					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					CAGCCGCCTCCACCTAGGTTC	0.632000													38	67					0	0	1	0	0
LRRC37B	114659	broad.mit.edu	37	17	30349287	30349287	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:30349287C>T	ENST00000327564.7	+	1	1264	c.1203C>T	c.(1201-1203)ccC>ccT	p.P401P	LRRC37B_ENST00000543378.2_Silent_p.P292P|LRRC37B_ENST00000584368.1_Silent_p.P386P|LRRC37B_ENST00000341671.7_Silent_p.P374P|LRRC37B_ENST00000394713.3_Silent_p.P374P			Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B	374						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	29		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				TTCAGCCTCCCGAGGAGGCGG	0.537000													27	59					0	0	1	0	0
PRKCB	5579	broad.mit.edu	37	16	24226007	24226007	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr16:24226007G>A	ENST00000303531.7	+	17	2044	c.1892G>A	c.(1891-1893)cGa>cAa	p.R631Q	PRKCB_ENST00000321728.7_Intron	NM_002738.6	NP_002729.2	P05771	KPCB_HUMAN	protein kinase C, beta	632	AGC-kinase C-terminal.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			central_nervous_system(3)|large_intestine(1)|lung(2)|ovary(3)	9					Vitamin E(DB00163)	AACTTCGACCGATTTTTCACC	0.423000													15	18					0	0	1	0	0
RGS8	85397	broad.mit.edu	37	1	182636032	182636032	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:182636032G>A	ENST00000483095.2	-	4	360	c.103C>T	c.(103-105)Cca>Tca	p.P35S	RGS8_ENST00000367556.1_Missense_Mutation_p.P35S|RGS8_ENST00000367557.4_Missense_Mutation_p.P35S|RGS8_ENST00000258302.4_Missense_Mutation_p.P53S|RGS8_ENST00000491420.2_5'UTR			P57771	RGS8_HUMAN	regulator of G-protein signaling 8	35					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			haematopoietic_and_lymphoid_tissue(1)|ovary(1)|stomach(2)|upper_aerodigestive_tract(1)	5						GGTTTGTCTGGAAGAATAGCT	0.502000													24	25					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40980743	40980743	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:40980743C>T	ENST00000373198.3	-	10	1978	c.1743G>A	c.(1741-1743)cgG>cgA	p.R581R	PTPRT_ENST00000373187.1_Silent_p.R581R|PTPRT_ENST00000373193.3_Silent_p.R581R|PTPRT_ENST00000373201.1_Silent_p.R581R|PTPRT_ENST00000356100.2_Silent_p.R581R|PTPRT_ENST00000373184.1_Silent_p.R581R|PTPRT_ENST00000373190.1_Silent_p.R581R	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	581	Fibronectin type-III 3.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TGGTGGCAATCCGAGTGGTGA	0.478000													14	29					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73063725	73063725	+	RNA	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:73063725G>A	ENST00000429829.1	-	0	8863					NR_001564.2																						AGGTGATGGGGTATGACCTTA	0.403000													5	4					0	0	1	0	0
CDH22	64405	broad.mit.edu	37	20	44869865	44869865	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:44869865G>A	ENST00000372262.3	-	2	687	c.287C>T	c.(286-288)gCc>gTc	p.A96V	CDH22_ENST00000537909.1_Missense_Mutation_p.A96V	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	96	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				GTACTTGATGGCCCCGTCACC	0.597000													4	7					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176762710	176762710	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:176762710C>T	ENST00000367662.3	+	20	6199	c.5035C>T	c.(5035-5037)Cca>Tca	p.P1679S		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1679	Sushi 5.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding	p.P1679A(1)		NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						AGTGTGTTCCCCATTGTGTGT	0.458000													12	21					0	0	1	0	0
MOG	4340	broad.mit.edu	37	6	29627144	29627144	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:29627144G>A	ENST00000376894.4	+	2	255	c.137G>A	c.(136-138)gGg>gAg	p.G46E	MOG_ENST00000431798.2_Missense_Mutation_p.G46E|MOG_ENST00000376891.4_Missense_Mutation_p.G46E|MOG_ENST00000533330.2_Missense_Mutation_p.G46E|MOG_ENST00000376917.3_Missense_Mutation_p.G46E|MOG_ENST00000494692.1_Missense_Mutation_p.G46E|MOG_ENST00000490427.1_Intron|MOG_ENST00000376898.3_Missense_Mutation_p.G46E|MOG_ENST00000483013.1_Intron|MOG_ENST00000416766.2_Missense_Mutation_p.G46E|MOG_ENST00000469603.1_3'UTR|MOG_ENST00000396701.2_Missense_Mutation_p.G46E|MOG_ENST00000396704.3_Missense_Mutation_p.G46E|MOG_ENST00000376888.2_Intron|MOG_ENST00000376902.3_Missense_Mutation_p.G46E			Q16653	MOG_HUMAN	myelin oligodendrocyte glycoprotein	46	Ig-like V-type.				cell adhesion|central nervous system development|positive regulation of MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)|skin(2)	19						GCTCTGGTCGGGGATGAAGTG	0.547000													45	94					0	0	1	0	0
EPB41L1	2036	broad.mit.edu	37	20	34773198	34773198	+	Silent	SNP	C	C	T	rs142551778	byFrequency	TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:34773198C>T	ENST00000338074.2	+	7	887	c.726C>T	c.(724-726)ttC>ttT	p.F242F	EPB41L1_ENST00000373941.1_Silent_p.F242F|EPB41L1_ENST00000373946.3_Silent_p.F211F|EPB41L1_ENST00000373950.2_Silent_p.F145F|EPB41L1_ENST00000441639.1_Silent_p.F180F|EPB41L1_ENST00000202028.5_Silent_p.F180F	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	242	FERM.				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					AGCTCCGCTTCGCCCCTAACC	0.592000													8	15					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51872583	51872583	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:51872583G>A	ENST00000371497.5	+	2	3473	c.2586G>A	c.(2584-2586)tcG>tcA	p.S862S	TSHZ2_ENST00000329613.6_Silent_p.S859S|TSHZ2_ENST00000603338.2_Silent_p.S859S|RP4-678D15.1_ENST00000606932.1_RNA	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	862					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			AGTTTGCCTCGAGCCTCTTCC	0.483000													7	22					0	0	1	0	0
ZNF600	162966	broad.mit.edu	37	19	53269323	53269323	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:53269323G>A	ENST00000338230.3	-	3	1953	c.1686C>T	c.(1684-1686)acC>acT	p.T562T		NM_198457.2	NP_940859.2	Q6ZNG1	ZN600_HUMAN	zinc finger protein 600	562					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.T562T(1)		breast(2)|endometrium(2)|kidney(4)|large_intestine(9)|liver(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(262;0.0241)|GBM - Glioblastoma multiforme(134;0.0404)		TGTGACTGAAGGTCTTGCCAC	0.438000													106	90					0	0	1	0	0
BPIFB1	92747	broad.mit.edu	37	20	31887785	31887785	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:31887785C>T	ENST00000253354.1	+	8	903	c.742C>T	c.(742-744)Ctg>Ttg	p.L248L	BPIFB1_ENST00000464032.1_3'UTR	NM_033197.2	NP_149974.2	Q8TDL5	LPLC1_HUMAN	BPI fold containing family B, member 1	248						extracellular space	lipid binding										TCAGCTCTACCTGGGGGTGAG	0.537000											OREG0025869	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	18					0	0	1	0	0
MYLK3	91807	broad.mit.edu	37	16	46744583	46744583	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr16:46744583C>T	ENST00000394809.4	-	11	2348	c.2233G>A	c.(2233-2235)Gac>Aac	p.D745N	MYLK3_ENST00000562104.1_5'UTR|MYLK3_ENST00000536476.1_Missense_Mutation_p.D404N	NM_182493.2	NP_872299.2	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	745	Protein kinase.				cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(5)|stomach(3)	37		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				GAAACAAAGTCCTTGGCCTCC	0.507000													51	17					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90428729	90428729	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:90428729G>A	ENST00000369393.3	-	42	6193	c.6078C>T	c.(6076-6078)tcC>tcT	p.S2026S	MDN1_ENST00000428876.1_Silent_p.S2026S			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	2026					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AGCTCCCACGGGAAAGGACTG	0.512000													18	25					0	0	1	0	0
URB2	9816	broad.mit.edu	37	1	229794885	229794885	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:229794885G>T	ENST00000258243.2	+	10	4552	c.4416G>T	c.(4414-4416)gaG>gaT	p.E1472D		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	1472						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						TGCTGCAGGAGGGCATTTACC	0.537000													43	76					1.97e-11	2.00292e-11	1	1	0
TLL1	7092	broad.mit.edu	37	4	166964455	166964455	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:166964455G>A	ENST00000061240.2	+	12	2055	c.1408G>A	c.(1408-1410)Gaa>Aaa	p.E470K	TLL1_ENST00000507499.1_Missense_Mutation_p.E470K	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	470	CUB 2.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		ACGTAAAAATGAAGGACAGAT	0.413000													33	23					0	0	1	0	0
RASEF	158158	broad.mit.edu	37	9	85640715	85640715	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:85640715C>T	ENST00000376447.3	-	2	813	c.553G>A	c.(553-555)Gaa>Aaa	p.E185K		NM_152573.2	NP_689786.2	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	185					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(4)|liver(1)|lung(15)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	33						GCCAAATTTTCCATTTCTGTG	0.428000													41	13					0	0	1	0	0
OPLAH	26873	broad.mit.edu	37	8	145111546	145111546	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:145111546C>T	ENST00000426825.1	-	13	1900	c.1819G>A	c.(1819-1821)Gac>Aac	p.D607N	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	607							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	GCCCCGAAGTCCCCCGCACGG	0.672000													12	29					0	0	1	0	0
SNTG2	54221	broad.mit.edu	37	2	1168853	1168853	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:1168853G>A	ENST00000308624.5	+	8	704	c.575G>A	c.(574-576)gGa>gAa	p.G192E	SNTG2_ENST00000407292.1_Intron|SNTG2_ENST00000467759.1_3'UTR	NM_018968.3	NP_061841.2	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	192					central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		CATCTGAACGGAAACTCCAGT	0.443000													37	73					0	0	1	0	0
ITSN1	6453	broad.mit.edu	37	21	35195852	35195852	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr21:35195852G>A	ENST00000381318.3	+	25	3366	c.3078G>A	c.(3076-3078)ggG>ggA	p.G1026G	ITSN1_ENST00000399349.1_Intron|ITSN1_ENST00000399367.3_Silent_p.G1021G|ITSN1_ENST00000399326.3_Intron|ITSN1_ENST00000379960.5_Intron|ITSN1_ENST00000381291.4_Silent_p.G1026G|ITSN1_ENST00000381285.4_Silent_p.G1026G|ITSN1_ENST00000399352.1_Silent_p.G1021G|ITSN1_ENST00000437442.2_Silent_p.G1021G|ITSN1_ENST00000399355.2_Intron|ITSN1_ENST00000399353.1_Silent_p.G984G|AP000304.12_ENST00000429238.1_Intron	NM_003024.2	NP_003015.2	Q15811	ITSN1_HUMAN	intersectin 1 (SH3 domain protein)	1026	SH3 3.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(26)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	67						TTCAGCAAGGGGATGTGATTT	0.448000													21	34					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152192141	152192141	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:152192141C>T	ENST00000368801.2	-	3	2039	c.1964G>A	c.(1963-1965)gGa>gAa	p.G655E	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	655					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGGCCAGATCCAGAGCCCTG	0.582000													61	151					0	0	1	0	0
SUCLG1	8802	broad.mit.edu	37	2	84658752	84658752	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:84658752A>T	ENST00000393868.2	-	7	915	c.705T>A	c.(703-705)gaT>gaA	p.D235E	SUCLG1_ENST00000491123.1_5'UTR	NM_003849.3	NP_003840.2	P53597	SUCA_HUMAN	succinate-CoA ligase, alpha subunit	235					tricarboxylic acid cycle		ATP citrate synthase activity|GTP binding|succinate-CoA ligase (GDP-forming) activity			kidney(4)|large_intestine(4)|lung(2)	10					Succinic acid(DB00139)	AGTCAATAAAATCTGTTCCAT	0.363000													19	22					0	0	1	0	0
TGM4	7047	broad.mit.edu	37	3	44952563	44952563	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:44952563G>A	ENST00000296125.4	+	12	1788	c.1720G>A	c.(1720-1722)Gaa>Aaa	p.E574K		NM_003241.3	NP_003232.2	P49221	TGM4_HUMAN	transglutaminase 4	574					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(9)|lung(21)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	38				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	GGAGTCTAAGGAAATCATGGC	0.468000													10	36					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207170584	207170584	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:207170584A>T	ENST00000374423.3	+	5	1718	c.1332A>T	c.(1330-1332)aaA>aaT	p.K444N		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	444							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						AGAATAATAAATCTTATGTTT	0.333000													5	14					0	0	1	0	0
CAPN9	10753	broad.mit.edu	37	1	230895258	230895258	+	Splice_Site	SNP	G	G	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:230895258G>C	ENST00000354537.1	+	3	366	c.283_splice	c.e3-1	p.G95_splice	CAPN9_ENST00000366666.2_Intron|RP11-99J16__A.2_ENST00000412344.1_RNA|CAPN9_ENST00000271971.2_Splice_Site_p.G95_splice	NM_016452.1	NP_057536.1	O14815	CAN9_HUMAN	calpain 9	95	Calpain catalytic.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	25	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				CATTTTGCAGGAGACTGCTGG	0.488000													18	31					0	0	1	0	0
MLXIPL	51085	broad.mit.edu	37	7	73020076	73020076	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:73020076C>T	ENST00000313375.3	-	7	890	c.843G>A	c.(841-843)atG>atA	p.M281I	MLXIPL_ENST00000434326.1_Missense_Mutation_p.M188I|MLXIPL_ENST00000395189.1_Missense_Mutation_p.M188I|MLXIPL_ENST00000414749.2_Missense_Mutation_p.M281I|MLXIPL_ENST00000354613.1_Missense_Mutation_p.M281I|MLXIPL_ENST00000429400.2_Missense_Mutation_p.M281I	NM_032951.2|NM_032953.2	NP_116569.1|NP_116571.1	Q9NP71	WBS14_HUMAN	MLX interacting protein-like	281					anatomical structure morphogenesis|energy reserve metabolic process|glucose mediated signaling pathway|intracellular protein kinase cascade|negative regulation of cell cycle arrest|negative regulation of oxidative phosphorylation|negative regulation of peptidyl-serine phosphorylation|positive regulation of cell proliferation|positive regulation of fatty acid biosynthetic process|positive regulation of glycolysis|positive regulation of transcription from RNA polymerase II promoter|triglyceride homeostasis	cytosol|transcription factor complex	carbohydrate response element binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			cervix(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	13		Lung NSC(55;0.0659)|all_lung(88;0.152)				CCGGCTGGATCATGTCAGCAT	0.667000													8	12					0	0	1	0	0
SOBP	55084	broad.mit.edu	37	6	107955796	107955796	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:107955796C>T	ENST00000317357.5	+	6	2407	c.1748C>T	c.(1747-1749)tCc>tTc	p.S583F		NM_018013.3	NP_060483.3	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog (Drosophila)	583							metal ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	26		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		CACTCCCTGTCCCCCCGGGAC	0.731000													12	7					0	0	1	0	0
PRDX6	9588	broad.mit.edu	37	1	173456933	173456933	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:173456933C>T	ENST00000340385.5	+	5	738	c.606C>T	c.(604-606)ttC>ttT	p.F202F	PRDX6_ENST00000470017.1_3'UTR	NM_004905.2	NP_004896.1	P30041	PRDX6_HUMAN	peroxiredoxin 6	202					cell redox homeostasis|phospholipid catabolic process	cytoplasmic membrane-bounded vesicle|cytosol|lysosome	peroxiredoxin activity|phospholipase A2 activity|protein binding			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|urinary_tract(1)	12						AAAAACTTTTCCCGAAAGGAG	0.468000													12	29					0	0	1	0	0
ARID4A	5926	broad.mit.edu	37	14	58768348	58768348	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:58768348G>A	ENST00000355431.3	+	3	430	c.57G>A	c.(55-57)aaG>aaA	p.K19K	ARID4A_ENST00000395168.3_Silent_p.K19K|ARID4A_ENST00000431317.2_Silent_p.K19K|ARID4A_ENST00000348476.3_Silent_p.K19K	NM_002892.3	NP_002883.3	P29374	ARI4A_HUMAN	AT rich interactive domain 4A (RBP1-like)	19					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(4)|endometrium(8)|kidney(2)|large_intestine(14)|lung(19)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						TCAGTGCCAAGTACCGAGGTG	0.428000													10	8					0	0	1	0	0
XRN1	54464	broad.mit.edu	37	3	142083993	142083993	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:142083993G>A	ENST00000264951.4	-	29	3407	c.3290C>T	c.(3289-3291)cCt>cTt	p.P1097L	XRN1_ENST00000392981.2_Missense_Mutation_p.P1097L	NM_019001.3	NP_061874.3	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1	1097					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(6)|kidney(12)|large_intestine(11)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	61						ATCCCGATCAGGAATGACTCC	0.348000													12	26					0	0	1	0	0
ZNF43	7594	broad.mit.edu	37	19	21991463	21991463	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:21991463C>A	ENST00000594012.1	-	7	1872	c.1358G>T	c.(1357-1359)tGt>tTt	p.C453F	ZNF43_ENST00000595461.1_Missense_Mutation_p.C453F|ZNF43_ENST00000354959.4_Missense_Mutation_p.C459F|ZNF43_ENST00000598381.1_Missense_Mutation_p.C453F	NM_001256649.1|NM_001256651.1|NM_001256653.1|NM_001256654.1	NP_001243578.1|NP_001243580.1|NP_001243582.1|NP_001243583.1	P17038	ZNF43_HUMAN	zinc finger protein 43	459					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	51		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		GGCTTTGCCACATACTTCACA	0.383000													29	39					1.32181e-22	1.35342e-22	1	1	0
TM9SF4	9777	broad.mit.edu	37	20	30746296	30746296	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:30746296C>T	ENST00000217315.5	+	15	1837	c.1497C>T	c.(1495-1497)atC>atT	p.I499I	TM9SF4_ENST00000398022.2_Silent_p.I516I			Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	516						integral to membrane				central_nervous_system(2)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CCATGTTCATCGAGCTCTTCT	0.592000													24	30					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13870977	13870977	+	Missense_Mutation	SNP	G	G	A	rs149609746		TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:13870977G>A	ENST00000265104.4	-	24	3837	c.3733C>T	c.(3733-3735)Cgt>Tgt	p.R1245C	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1245	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTAATTGGACGATTTAGTTTC	0.393000									Kartagener syndrome				7	26					0	0	1	0	0
OR52E4	390081	broad.mit.edu	37	11	5906312	5906312	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:5906312C>T	ENST00000316987.2	+	1	812	c.790C>T	c.(790-792)Cgt>Tgt	p.R264C		NM_001005165.1	NP_001005165.1	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E, member 4	264					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(2)|prostate(1)|skin(2)	30		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TATGACACATCGTTTTGGCCA	0.428000													31	50					0	0	1	0	0
ABCG8	64241	broad.mit.edu	37	2	44079944	44079944	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:44079944G>A	ENST00000272286.2	+	6	991	c.901G>A	c.(901-903)Gtc>Atc	p.V301I		NM_022437.2	NP_071882.1	Q9H221	ABCG8_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 8	301	ABC transporter.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(21)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CCAGCACATGGTCCAGTATTT	0.597000													23	39					0	0	1	0	0
GSDMA	284110	broad.mit.edu	37	17	38133214	38133214	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:38133214C>T	ENST00000301659.4	+	12	1359	c.1241C>T	c.(1240-1242)tCg>tTg	p.S414L		NM_178171.4	NP_835465.2	Q96QA5	GSDMA_HUMAN	gasdermin A	414					apoptosis|induction of apoptosis	perinuclear region of cytoplasm				NS(1)|endometrium(2)|large_intestine(3)|lung(1)	7						GTGCAGAGATCGGGCCCCCAA	0.592000													23	30					0	0	1	0	0
RWDD1	51389	broad.mit.edu	37	6	116910104	116910104	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:116910104G>A	ENST00000466444.2	+	4	586	c.370G>A	c.(370-372)Gaa>Aaa	p.E124K	RWDD1_ENST00000392526.1_Missense_Mutation_p.E28K|RWDD1_ENST00000487832.2_Missense_Mutation_p.E28K	NM_015952.2	NP_057036.2	Q9H446	RWDD1_HUMAN	RWD domain containing 1	124				TRREEEKKQKE -> LEERRKNKR (in Ref. 1; AAD27733).			protein binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)|skin(1)	12		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.0312)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)|Epithelial(106;0.161)		Tagaagagaagaagaaaagaa	0.294000													5	13					0	0	1	0	0
ZFP14	57677	broad.mit.edu	37	19	36858788	36858788	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:36858788G>A	ENST00000270001.7	-	2	122	c.7C>T	c.(7-9)Cat>Tat	p.H3Y	ZFP14_ENST00000589280.1_Missense_Mutation_p.H3Y	NM_020917.2	NP_065968.1	Q9HCL3	ZFP14_HUMAN	ZFP14 zinc finger protein	3					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	26	Esophageal squamous(110;0.162)					TAACTTACATGGGCCATGGTT	0.368000													11	14					0	0	1	0	0
EXT1	2131	broad.mit.edu	37	8	118832011	118832011	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:118832011G>A	ENST00000378204.2	-	6	2246	c.1440C>T	c.(1438-1440)ttC>ttT	p.F480F		NM_000127.2	NP_000118.2	Q16394	EXT1_HUMAN	exostosin glycosyltransferase 1	480					glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(12)|lung(10)|ovary(3)|prostate(1)|stomach(1)|urinary_tract(2)	38	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)			TGACTGCAGTGAATTTGGAGG	0.522000			"""Mis, N, F, S"""			"""exostoses, osteosarcoma"""			Langer-Giedion syndrome;Hereditary Multiple Exostoses				27	105					0	0	1	0	0
MUC3A	4584	broad.mit.edu	37	7	100552304	100552304	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:100552304C>T	ENST00000319509.7	+	1	1055	c.1055C>T	c.(1054-1056)cCc>cTc	p.P352L						mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						ACTTCTCCTCCCACCACCCCA	0.463000													17	301					0	0	1	0	0
NRAS	4893	broad.mit.edu	37	1	115256529	115256529	+	Missense_Mutation	SNP	T	T	C	rs11554290		TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:115256529T>C	ENST00000369535.4	-	3	435	c.182A>G	c.(181-183)cAa>cGa	p.Q61R		NM_002524.4	NP_002515.1	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61			Q -> K (in neuroblastoma cell).|Q -> R (in lung carcinoma cell and melanoma; dbSNP:rs11554290).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(817)|p.Q61L(175)|p.Q61P(23)|p.Q61K(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCTTCTTGTCCAGCTGT	0.458000	Q61L(C3A_LIVER)|Q61L(HEPG2_LIVER)|Q61L(HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(IPC298_SKIN)|Q61L(KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MELJUSO_SKIN)|Q61L(MHHES1_BONE)|Q61L(MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61P(TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(HT1197_URINARY_TRACT)|Q61R(KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(KU1919_URINARY_TRACT)|Q61R(NCIH2347_LUNG)|Q61R(ONS76_CENTRAL_NERVOUS_SYSTEM)|Q61R(SKMEL2_SKIN)|Q61R(SW1271_LUNG)|Q61R(TT2609C02_THYROID)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			29	57					0	0	1	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64595853	64595853	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:64595853G>A	ENST00000536360.1	-	10	2142	c.1329C>T	c.(1327-1329)tcC>tcT	p.S443S				Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 6	443	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(3)	18		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		AAGCAGACCAGGAAAAAGGAT	0.433000													10	14					0	0	1	0	0
DENND3	22898	broad.mit.edu	37	8	142151402	142151402	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:142151402C>T	ENST00000519811.1	+	4	672	c.602C>T	c.(601-603)tCc>tTc	p.S201F	DENND3_ENST00000518347.1_Missense_Mutation_p.S201F|DENND3_ENST00000424248.1_Missense_Mutation_p.S121F|DENND3_ENST00000262585.2_Missense_Mutation_p.S121F			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	121	DENN.									breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			TATTACAACTCCCTCAAGGAC	0.612000													25	104					0	0	1	0	0
CFH	3075	broad.mit.edu	37	1	196695675	196695675	+	Missense_Mutation	SNP	G	G	A	rs143237092		TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:196695675G>A	ENST00000367429.4	+	13	2189	c.1949G>A	c.(1948-1950)gGa>gAa	p.G650E		NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	650	Sushi 11.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						GAAGAATATGGACACAGTGAA	0.363000													22	25					0	0	1	0	0
TTC40	54777	broad.mit.edu	37	10	134650321	134650321	+	Splice_Site	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:134650321C>T	ENST00000368586.5	-	45	6636	c.6536_splice	c.e45+1	p.R2179_splice	TTC40_ENST00000263170.5_Splice_Site_p.R340_splice	NM_001200049.2	NP_001186978.2	Q8IYW2	CJ092_HUMAN	tetratricopeptide repeat domain 40	340										breast(1)|endometrium(5)|lung(19)|urinary_tract(3)	28						GCGGCTTTACCTGTCCCCTGA	0.602000													35	45					0	0	1	0	0
PCDH20	64881	broad.mit.edu	37	13	61986306	61986306	+	Silent	SNP	C	C	T	rs144379684		TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr13:61986306C>T	ENST00000409186.1	-	5	4031	c.1926G>A	c.(1924-1926)aaG>aaA	p.K642K	PCDH20_ENST00000409204.4_Silent_p.K642K			Q8N6Y1	PCD20_HUMAN	protocadherin 20	615	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(14)|liver(1)|lung(23)|ovary(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	58		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		AGCTGAAGTCCTTGTTGATAA	0.478000													59	11					0	0	1	0	0
LIN7A	8825	broad.mit.edu	37	12	81239603	81239603	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:81239603G>A	ENST00000552864.1	-	4	591	c.389C>T	c.(388-390)tCc>tTc	p.S130F		NM_004664.2	NP_004655.1	O14910	LIN7A_HUMAN	lin-7 homolog A (C. elegans)	130	PDZ.				exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|skin(2)	15						ATAAATGGGGGAATTTTGCTC	0.493000													11	24					0	0	1	0	0
CSF2RB	1439	broad.mit.edu	37	22	37333850	37333850	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr22:37333850C>T	ENST00000262825.5	+	14	2235	c.2018C>T	c.(2017-2019)tCc>tTc	p.S673F	CSF2RB_ENST00000403662.3_Missense_Mutation_p.S667F|CSF2RB_ENST00000536485.1_Missense_Mutation_p.S614F|CSF2RB_ENST00000406230.1_Missense_Mutation_p.S673F	NM_000395.2	NP_000386.1	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	667					respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(3)|pancreas(1)|skin(5)|upper_aerodigestive_tract(2)	42					Sargramostim(DB00020)	GGGAGTCCCTCCCTGGAGTCC	0.682000													5	4					0	0	1	0	0
GLYATL1	92292	broad.mit.edu	37	11	58723296	58723296	+	Missense_Mutation	SNP	G	G	A	rs144071638		TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:58723296G>A	ENST00000300079.5	+	7	848	c.798G>A	c.(796-798)atG>atA	p.M266I	GLYATL1_ENST00000317391.4_Missense_Mutation_p.M235I|RP11-142C4.6_ENST00000533954.1_RNA	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	235						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	CCTACAGCATGGAAAAATACC	0.493000													15	21					0	0	1	0	0
GRIA4	2893	broad.mit.edu	37	11	105483088	105483088	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:105483088G>A	ENST00000393127.2	+	3	620	c.174G>A	c.(172-174)tcG>tcA	p.S58S	GRIA4_ENST00000282499.5_Silent_p.S58S|GRIA4_ENST00000393125.2_Silent_p.S58S|GRIA4_ENST00000525187.1_Silent_p.S58S|GRIA4_ENST00000428631.2_Silent_p.S58S|GRIA4_ENST00000527669.1_Silent_p.S58S|GRIA4_ENST00000530497.1_Silent_p.S58S	NM_001077243.2	NP_001070711.2	P48058	GRIA4_HUMAN	glutamate receptor, ionotropic, AMPA 4	58					glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(24)|liver(2)|lung(25)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	82		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	CCAATGCGTCGGAAGCTCCTT	0.393000													15	44					0	0	1	0	0
GP1BA	2811	broad.mit.edu	37	17	4837429	4837429	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:4837429G>A	ENST00000329125.5	+	2	1605	c.1530G>A	c.(1528-1530)ggG>ggA	p.G510G		NM_000173.5	NP_000164.5	E7ES66	E7ES66_HUMAN	glycoprotein Ib (platelet), alpha polypeptide	510										central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(5)|stomach(1)|urinary_tract(1)	20						TGCTCCAAGGGCATTTGGAGA	0.502000													26	40					0	0	1	0	0
NUAK2	81788	broad.mit.edu	37	1	205277762	205277762	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:205277762C>T	ENST00000367157.3	-	3	577	c.451G>A	c.(451-453)Gaa>Aaa	p.E151K		NM_030952.1	NP_112214.1	Q9H093	NUAK2_HUMAN	NUAK family, SNF1-like kinase, 2	151	Protein kinase.				actin cytoskeleton organization|apoptosis|cellular response to glucose starvation|negative regulation of apoptosis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(3)|kidney(3)|large_intestine(4)|lung(4)|ovary(3)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	23	Breast(84;0.186)		BRCA - Breast invasive adenocarcinoma(75;0.117)			TGCCTAGCTTCGCGCTCACTG	0.562000													18	28					0	0	1	0	0
LRRC27	80313	broad.mit.edu	37	10	134161528	134161528	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:134161528G>A	ENST00000392638.2	+	6	789	c.594G>A	c.(592-594)ccG>ccA	p.P198P	LRRC27_ENST00000432555.2_Silent_p.P71P|LRRC27_ENST00000368610.3_Silent_p.P136P|LRRC27_ENST00000368612.1_Silent_p.P136P|LRRC27_ENST00000344079.5_Silent_p.P198P|LRRC27_ENST00000356571.4_3'UTR|LRRC27_ENST00000368613.4_Silent_p.P198P|LRRC27_ENST00000368614.3_Silent_p.P198P|LRRC27_ENST00000368615.3_Silent_p.P198P			Q9C0I9	LRC27_HUMAN	leucine rich repeat containing 27	198										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)	18		all_cancers(35;6.28e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;9.12e-05)|Epithelial(32;0.000116)|all cancers(32;0.000145)|BRCA - Breast invasive adenocarcinoma(275;0.218)		GTGACCTCCCGAGCCCAGGAC	0.557000													41	51					0	0	1	0	0
CARD8	22900	broad.mit.edu	37	19	48734041	48734041	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:48734041G>A	ENST00000391898.3	-	6	807	c.765C>T	c.(763-765)tcC>tcT	p.S255S	CARD8_ENST00000520753.1_Silent_p.S255S|CARD8_ENST00000520153.1_Silent_p.S205S|CARD8_ENST00000359009.4_Silent_p.S150S|ZNF114_ENST00000597695.1_Intron|CARD8_ENST00000519940.1_Silent_p.S255S|CARD8_ENST00000357778.5_5'UTR|CARD8_ENST00000447740.2_Silent_p.S205S|CARD8_ENST00000521613.1_Silent_p.S205S|CARD8_ENST00000520015.1_Silent_p.S255S	NM_001184900.1	NP_001171829.1	Q9Y2G2	CARD8_HUMAN	caspase recruitment domain family, member 8	150					negative regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion	cytoplasm|nucleus	caspase activator activity|NACHT domain binding|protein homodimerization activity			endometrium(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	15		all_lung(116;0.000112)|Lung NSC(112;0.000192)|all_epithelial(76;0.000349)|all_neural(266;0.0228)|Ovarian(192;0.113)|Prostate(7;0.184)		OV - Ovarian serous cystadenocarcinoma(262;0.000112)|all cancers(93;0.000293)|Epithelial(262;0.0129)|GBM - Glioblastoma multiforme(486;0.0336)		TACCTTGGAGGGAGATGAAGT	0.627000													20	50					0	0	1	0	0
DPF3	8110	broad.mit.edu	37	14	73137924	73137924	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:73137924C>T	ENST00000541685.1	-	9	1006	c.994G>A	c.(994-996)Gat>Aat	p.D332N	DPF3_ENST00000557704.1_5'UTR|DPF3_ENST00000556509.1_Intron|DPF3_ENST00000546183.1_Missense_Mutation_p.D342N	NM_012074.3	NP_036206.3	Q92784	DPF3_HUMAN	D4, zinc and double PHD fingers, family 3	160					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex	nucleic acid binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)	22				BRCA - Breast invasive adenocarcinoma(234;0.00649)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		TCTTCCAAATCGTCCTCATCA	0.572000													11	14					0	0	1	0	0
MICALCL	84953	broad.mit.edu	37	11	12316171	12316171	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:12316171C>T	ENST00000256186.2	+	3	1484	c.1193C>T	c.(1192-1194)tCc>tTc	p.S398F		NM_032867.2	NP_116256.2	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	398					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(5)|lung(5)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	30				Epithelial(150;0.00177)		TCACTTTTTTCCTCCCTCAGA	0.453000													40	65					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	94120310	94120310	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:94120310C>T	ENST00000369303.4	-	3	925	c.741G>A	c.(739-741)agG>agA	p.R247R	EPHA7_ENST00000369297.1_Silent_p.R247R	NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	247	Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TGCAGTGCATCCTGGGGGCGT	0.473000													15	24					0	0	1	0	0
UBE3D	90025	broad.mit.edu	37	6	83667033	83667033	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:83667033G>A	ENST00000369747.3	-	9	1269	c.1147C>T	c.(1147-1149)Cag>Tag	p.Q383*		NM_198920.1	NP_944602.1	Q7Z6J8	UB2CB_HUMAN	ubiquitin protein ligase E3D	383	HECT-like.					cytoplasm	ligase activity										TTGCTCACCTGAAAGGAATTC	0.463000													15	25					0	0	1	0	0
SLC22A9	114571	broad.mit.edu	37	11	63176257	63176257	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:63176257G>A	ENST00000279178.3	+	9	1756	c.1507G>A	c.(1507-1509)Gga>Aga	p.G503R	SLC22A9_ENST00000310969.4_3'UTR	NM_080866.2	NP_543142.2	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion transporter), member 9	503					transmembrane transport	integral to membrane				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	18						GATCATCTATGGAGTCTTCCC	0.488000													13	32					0	0	1	0	0
IGHG2	3501	broad.mit.edu	37	14	106110061	106110061	+	RNA	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:106110061G>A	ENST00000390545.2	-	0	556																											GTGCACGACGGTGAGGACGCT	0.562000													77	98					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176011635	176011635	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:176011635C>T	ENST00000510636.1	+	19	2627	c.2353C>T	c.(2353-2355)Ccc>Tcc	p.P785S	CDHR2_ENST00000261944.5_Missense_Mutation_p.P785S|CDHR2_ENST00000506348.1_Missense_Mutation_p.P785S	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	785	Cadherin 7.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						GAACCCAGACCCCCAGGGGGG	0.607000													14	51					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6681979	6681979	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:6681979C>T	ENST00000245907.6	-	35	4415	c.4323G>A	c.(4321-4323)agG>agA	p.R1441R		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	1441	Properdin-binding.				complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TGAGGGTGTTCCTATCGGAGA	0.532000													63	68					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57597027	57597027	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:57597027G>A	ENST00000243077.3	+	69	11241	c.10775G>A	c.(10774-10776)tGg>tAg	p.W3592*		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	3592	LDL-receptor class A 27.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GCGGGGCGCTGGAAATGCGAT	0.667000													3	13					0	0	1	0	0
AP5Z1	9907	broad.mit.edu	37	7	4830461	4830461	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:4830461C>T	ENST00000348624.4	+	16	2190	c.2096C>T	c.(2095-2097)aCc>aTc	p.T699I	AP5Z1_ENST00000490487.1_3'UTR	NM_014855.2	NP_055670.1	O43299	K0415_HUMAN	adaptor-related protein complex 5, zeta 1 subunit	699					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding										CAGGTGGTCACCGTGCTGATG	0.642000													5	8					0	0	1	0	0
KRT71	112802	broad.mit.edu	37	12	52942524	52942524	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:52942524C>T	ENST00000267119.5	-	4	843	c.774G>A	c.(772-774)atG>atA	p.M258I		NM_033448.2	NP_258259.1	Q3SY84	K2C71_HUMAN	keratin 71	258	Coil 1B.|Rod.						structural molecule activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.194)		TCTCCTGGTCCATGGATTCCA	0.522000													26	40					0	0	1	0	0
PTBP1	5725	broad.mit.edu	37	19	804073	804073	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:804073C>G	ENST00000356948.6	+	4	576	c.153C>G	c.(151-153)agC>agG	p.S51R	PTBP1_ENST00000394601.4_Missense_Mutation_p.S51R|PTBP1_ENST00000350092.4_Intron|PTBP1_ENST00000349038.4_Missense_Mutation_p.S51R	NM_002819.4	NP_002810.1	P26599	PTBP1_HUMAN	polypyrimidine tract binding protein 1	51					negative regulation of muscle cell differentiation|nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	mRNA binding|nucleotide binding|poly-pyrimidine tract binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(4)	19		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGGTGACAGCCGAAGTGCAG	0.587000													22	26					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23523409	23523409	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:23523409G>A	ENST00000296682.3	+	9	1074	c.892G>A	c.(892-894)Ggg>Agg	p.G298R		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	298	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						GATCACCAAGGGGAGAAACTG	0.438000										HNSCC(3;0.000094)			10	20					0	0	1	0	0
MAGEA11	4110	broad.mit.edu	37	X	148797546	148797546	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:148797546G>A	ENST00000355220.5	+	5	502	c.400G>A	c.(400-402)Ggc>Agc	p.G134S	MAGEA11_ENST00000333104.4_Missense_Mutation_p.G105S	NM_005366.4	NP_005357.2	P43364	MAGAB_HUMAN	melanoma antigen family A, 11	134						cytoplasm|nucleus	protein binding			cervix(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	9	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					AGAAGACCTGGGCCTGGTGGG	0.567000													18	9					0	0	1	0	0
BAZ1B	9031	broad.mit.edu	37	7	72892164	72892164	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:72892164G>A	ENST00000339594.4	-	7	1965	c.1627C>T	c.(1627-1629)Cgg>Tgg	p.R543W	BAZ1B_ENST00000404251.1_Missense_Mutation_p.R543W	NM_032408.3	NP_115784.1	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	543	Lys-rich.				ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			NS(1)|breast(5)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(5)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Lung NSC(55;0.0659)|all_lung(88;0.152)				TATTCTTTCCGTTGTTCTTCA	0.388000													56	87					0	0	1	0	0
PACSIN1	29993	broad.mit.edu	37	6	34497610	34497610	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:34497610G>A	ENST00000538621.1	+	6	1025	c.780G>A	c.(778-780)gaG>gaA	p.E260E	PACSIN1_ENST00000244458.2_Silent_p.E260E|PACSIN1_ENST00000374043.2_Silent_p.E218E	NM_001199583.1	NP_001186512.1	Q9BY11	PACN1_HUMAN	protein kinase C and casein kinase substrate in neurons 1	260					endocytosis		protein kinase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|prostate(2)	13						ACCTGGCTGAGAACAGCAGGT	0.587000													6	7					0	0	1	0	0
SEMA3A	10371	broad.mit.edu	37	7	83640353	83640353	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:83640353A>C	ENST00000265362.3	-	9	1294	c.980T>G	c.(979-981)gTg>gGg	p.V327G	SEMA3A_ENST00000436949.1_Missense_Mutation_p.V327G	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	327	Sema.				axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						AGTCGTAAACACTCCATATAC	0.294000													4	25					0	0	1	0	0
CEP170B	283638	broad.mit.edu	37	14	105356087	105356087	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:105356087G>C	ENST00000453495.1	+	13	4206	c.3978G>C	c.(3976-3978)gaG>gaC	p.E1326D	CEP170B_ENST00000556508.1_Missense_Mutation_p.E1255D|CEP170B_ENST00000418279.1_Missense_Mutation_p.E1220D|CEP170B_ENST00000414716.3_Missense_Mutation_p.E1290D					centrosomal protein 170B																		AGATTGCGGAGATTGCCAGGT	0.632000													14	36					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	167000049	167000049	+	Nonsense_Mutation	SNP	A	A	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:167000049A>C	ENST00000392766.2	-	19	2454	c.2114T>G	c.(2113-2115)tTa>tGa	p.L705*	ZBBX_ENST00000392764.1_Nonsense_Mutation_p.L676*|ZBBX_ENST00000392767.2_Nonsense_Mutation_p.L705*|ZBBX_ENST00000307529.5_Nonsense_Mutation_p.L744*|ZBBX_ENST00000455345.2_Nonsense_Mutation_p.L744*	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	705						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						CAGCACTTGTAATTCTTTTTC	0.333000													15	25					0	0	1	0	0
RGS9	8787	broad.mit.edu	37	17	63157006	63157006	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:63157006G>A	ENST00000449996.3	+	6	474	c.402G>A	c.(400-402)ggG>ggA	p.G134G	RGS9_ENST00000577186.1_3'UTR|RGS9_ENST00000443584.3_Silent_p.G134G|RGS9_ENST00000262406.9_Silent_p.G134G	NM_001081955.2	NP_001075424.1	O75916	RGS9_HUMAN	regulator of G-protein signaling 9	134					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(8)|liver(2)|lung(12)|ovary(2)|prostate(3)|skin(3)	41						AAAAGAAAGGGATTTTGGAAG	0.388000													30	28					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9065041	9065041	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:9065041C>T	ENST00000397910.4	-	3	22608	c.22405G>A	c.(22405-22407)Gag>Aag	p.E7469K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7471	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGAATTTTCTCCGTATCTGTG	0.483000													58	83					0	0	1	0	0
C6orf62	81688	broad.mit.edu	37	6	24718839	24718839	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:24718839T>C	ENST00000378119.4	-	1	2225	c.58A>G	c.(58-60)Aga>Gga	p.R20G	C6orf62_ENST00000378102.3_Intron|C6orf62_ENST00000540769.1_Intron	NM_030939.4	NP_112201.1	Q9GZU0	CF062_HUMAN	chromosome 6 open reading frame 62	20						intracellular				endometrium(2)|kidney(3)|large_intestine(2)|lung(3)	10						TTTTTCTTTCTAAGCTGAGCA	0.383000													17	31					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61831375	61831375	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:61831375C>T	ENST00000280772.1	-	37	9455	c.9264G>A	c.(9262-9264)gaG>gaA	p.E3088E	ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3088					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						AAGTTTTTATCTCTTTCCCTC	0.423000													8	78					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124383294	124383294	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:124383294C>T	ENST00000409039.3	+	55	9244	c.9219C>T	c.(9217-9219)atC>atT	p.I3073I		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3073	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AGCAGAAGATCGTGCTGGCGG	0.652000													6	4					0	0	1	0	0
LRRC32	2615	broad.mit.edu	37	11	76372417	76372417	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:76372417C>T	ENST00000407242.2	-	3	462	c.220G>A	c.(220-222)Gca>Aca	p.A74T	LRRC32_ENST00000404995.1_Missense_Mutation_p.A74T|LRRC32_ENST00000260061.5_Missense_Mutation_p.A74T|AP001189.4_ENST00000447519.1_RNA|LRRC32_ENST00000464145.1_Intron	NM_005512.2	NP_005503.1	Q14392	LRC32_HUMAN	leucine rich repeat containing 32	74						integral to plasma membrane				endometrium(1)|large_intestine(3)|lung(26)|upper_aerodigestive_tract(1)	31						TGACGAAGTGCTGTGTAGAAG	0.617000													14	21					0	0	1	0	0
PIWIL2	55124	broad.mit.edu	37	8	22140610	22140610	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:22140610C>T	ENST00000356766.6	+	5	637	c.489C>T	c.(487-489)atC>atT	p.I163I	PIWIL2_ENST00000521356.1_Silent_p.I163I|PIWIL2_ENST00000454009.2_Silent_p.I163I	NM_018068.3	NP_060538.2	Q8TC59	PIWL2_HUMAN	piwi-like RNA-mediated gene silencing 2	163					DNA methylation involved in gamete generation|gene silencing by RNA|germ-line stem cell maintenance|multicellular organismal development|oogenesis|piRNA metabolic process|positive regulation of translation|RNA 5'-end processing|spermatogenesis	chromatoid body|pi-body	piRNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(14)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	46				Colorectal(74;0.018)|COAD - Colon adenocarcinoma(73;0.0707)		CAGGTGGTATCAGCAGAGAAG	0.557000													7	14					0	0	1	0	0
RASSF9	9182	broad.mit.edu	37	12	86198822	86198822	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:86198822C>T	ENST00000361228.3	-	2	1334	c.966G>A	c.(964-966)ttG>ttA	p.L322L		NM_005447.3	NP_005438.2	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family (N-terminal) member 9	322					endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity	p.L322F(2)		endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TGCTTTTCTCCAAATCACACT	0.373000													47	86					0	0	1	0	0
KRTAP4-9	100132386	broad.mit.edu	37	17	39261715	39261715	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:39261715C>T	ENST00000391415.1	+	1	132	c.75C>T	c.(73-75)tgC>tgT	p.C25C		NM_001146041.1	NP_001139513.1	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	25	29 X 5 AA repeats of C-C-[RQVHIEK]- [SPTR]-[VSTQCRNP].					keratin filament				central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|urinary_tract(3)	14						AGACCTGCTGCCGCCCCAGCT	0.642000													17	18					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34961028	34961028	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:34961028C>T	ENST00000329357.5	+	1	116	c.80C>T	c.(79-81)tCc>tTc	p.S27F		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	27										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						AAACCGCCTTCCAAGTACTTC	0.622000													9	15					0	0	1	0	0
SASH1	23328	broad.mit.edu	37	6	148855984	148855984	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:148855984C>T	ENST00000367467.3	+	16	2517	c.2042C>T	c.(2041-2043)cCg>cTg	p.P681L		NM_015278.3	NP_056093.3	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	681	SAM 1.						protein binding	p.P681Q(1)		breast(4)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		ATCAGGGACCCGGAACACAGA	0.488000													16	21					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108135721	108135721	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:108135721C>T	ENST00000273353.3	-	30	4002	c.3946G>A	c.(3946-3948)Gaa>Aaa	p.E1316K		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1316						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						TTGCTCTTTTCCCTGGAAAGT	0.418000													21	39					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153190772	153190772	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:153190772C>T	ENST00000285900.5	+	16	3051	c.2708C>T	c.(2707-2709)gCc>gTc	p.A903V	GRIA1_ENST00000340592.5_Missense_Mutation_p.A903V|GRIA1_ENST00000518783.1_Missense_Mutation_p.A913V|GRIA1_ENST00000518142.1_Missense_Mutation_p.A823V|GRIA1_ENST00000521843.2_Missense_Mutation_p.A834V|GRIA1_ENST00000448073.4_Missense_Mutation_p.A913V	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	903					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CCCTTGGGAGCCACGGGATTG	0.572000													11	13					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43433819	43433819	+	RNA	SNP	T	T	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:43433819T>G	ENST00000446844.3	-	0	573				PSG7_ENST00000406070.2_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				ACAGCCTCCGTGGCCTCCCTG	0.532000													119	71					0	0	1	0	0
MROH7	374977	broad.mit.edu	37	1	55152105	55152105	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:55152105C>T	ENST00000414150.2	+	15	2973	c.2695C>T	c.(2695-2697)Ccc>Tcc	p.P899S	MROH7_ENST00000409996.1_Missense_Mutation_p.P467S|MROH7_ENST00000395690.2_Missense_Mutation_p.P899S|MROH7_ENST00000339553.5_Missense_Mutation_p.P899S|MROH7_ENST00000454855.2_Missense_Mutation_p.P417S|MROH7_ENST00000421030.2_Missense_Mutation_p.P899S|MROH7_ENST00000545244.1_Missense_Mutation_p.P467S					maestro heat-like repeat family member 7																		ACAGCCCTCTCCCTTCGTACC	0.622000													13	19					0	0	1	0	0
NMUR1	10316	broad.mit.edu	37	2	232393194	232393194	+	Nonsense_Mutation	SNP	G	G	A	rs141278960		TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:232393194G>A	ENST00000305141.4	-	2	671	c.538C>T	c.(538-540)Cga>Tga	p.R180*		NM_006056.4	NP_006047.3	Q9HB89	NMUR1_HUMAN	neuromedin U receptor 1	180					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|calcium ion transport|calcium-mediated signaling|chloride transport|smooth muscle contraction	integral to plasma membrane|membrane fraction	neuromedin U receptor activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(12)|pancreas(1)|skin(1)	24		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;8.37e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		CCAAGCACTCGGCGCACATGG	0.687000													16	7					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11648221	11648221	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:11648221C>T	ENST00000262442.3	+	31	6287	c.6219C>T	c.(6217-6219)tcC>tcT	p.S2073S	DNAH9_ENST00000454412.2_Silent_p.S2073S	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2073					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TGATGCGCTCCTTGCGGGATT	0.612000													10	24					0	0	1	0	0
FAM49A	81553	broad.mit.edu	37	2	16769331	16769331	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:16769331G>C	ENST00000381323.3	-	3	277	c.57C>G	c.(55-57)ttC>ttG	p.F19L	FAM49A_ENST00000355549.2_Missense_Mutation_p.F19L|FAM49A_ENST00000406434.1_Missense_Mutation_p.F19L	NM_030797.3	NP_110424.1	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A	19						intracellular				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			CAAAATCCAGGAAAAAGTGTG	0.318000													4	13					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152080416	152080416	+	Silent	SNP	C	C	T	rs71585886		TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:152080416C>T	ENST00000368804.1	-	2	5276	c.5277G>A	c.(5275-5277)agG>agA	p.R1759R		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1759	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTGTTCTTCCCTTTCCGGAC	0.602000													24	43					0	0	1	0	0
CLEC17A	388512	broad.mit.edu	37	19	14705358	14705358	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:14705358G>A	ENST00000547437.1	+	5	384	c.307G>A	c.(307-309)Gca>Aca	p.A103T	CLEC17A_ENST00000417570.1_Missense_Mutation_p.A103T|CLEC17A_ENST00000397439.2_Missense_Mutation_p.A86T	NM_207390.3	NP_997273.3	Q6ZS10	CL17A_HUMAN	C-type lectin domain family 17, member A	103						cell surface|integral to membrane	fucose binding|mannose binding|metal ion binding|receptor activity										ACCTCCAAGGGCAGGTGAGTT	0.582000													11	9					0	0	1	0	0
MKRN3	7681	broad.mit.edu	37	15	23812054	23812054	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:23812054G>A	ENST00000314520.3	+	1	1601	c.1125G>A	c.(1123-1125)gaG>gaA	p.E375E	MKRN3_ENST00000564592.1_Silent_p.E135E|MKRN3_ENST00000568945.1_3'UTR|MKRN3_ENST00000568252.1_Intron	NM_005664.3	NP_005655.1	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	375						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(33)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		TTCCCAGTGAGTTCTGGGTGG	0.517000													17	60					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	166924575	166924575	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:166924575G>A	ENST00000061240.2	+	6	1312	c.665G>A	c.(664-666)gGa>gAa	p.G222E	TLL1_ENST00000513213.1_Missense_Mutation_p.G222E|TLL1_ENST00000507499.1_Missense_Mutation_p.G222E	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	222	Metalloprotease (By similarity).				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		CGAGGAAATGGACCTCAGGCA	0.448000													15	7					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41033256	41033256	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:41033256C>T	ENST00000399564.4	-	23	2698	c.2248G>A	c.(2248-2250)Gat>Aat	p.D750N	MROH2B_ENST00000506092.2_Missense_Mutation_p.D305N	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		ATTTGCAGATCCATGTCCTAA	0.428000													3	10					0	0	1	0	0
SULT1C3	442038	broad.mit.edu	37	2	108875273	108875273	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:108875273G>A	ENST00000329106.2	+	5	610	c.610G>A	c.(610-612)Gat>Aat	p.D204N	SULT1C3_ENST00000376700.1_Missense_Mutation_p.D204N	NM_001008743.1	NP_001008743.1	Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member 3	204						cytoplasm	alcohol sulfotransferase activity			breast(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(4)	16						CTTCTACGAGGATATTAAAAA	0.453000													14	13					0	0	1	0	0
KIAA1549	57670	broad.mit.edu	37	7	138555970	138555970	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:138555970G>A	ENST00000440172.1	-	13	4532	c.4484C>T	c.(4483-4485)cCg>cTg	p.P1495L	KIAA1549_ENST00000242365.4_Missense_Mutation_p.P1445L|KIAA1549_ENST00000422774.1_Missense_Mutation_p.P1495L	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	1495						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						GGGAGGTGCCGGGATCGGCTG	0.567000			O	BRAF	pilocytic astrocytoma								20	20					0	0	1	0	0
OR6N1	128372	broad.mit.edu	37	1	158736386	158736386	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:158736386G>A	ENST00000335094.2	-	1	106	c.87C>T	c.(85-87)ctC>ctT	p.L29L		NM_001005185.1	NP_001005185.1	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N, member 1	29					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_hematologic(112;0.0378)					GAAGCAACAAGAGGAAGAGAT	0.502000													17	21					0	0	1	0	0
ADIPOQ	9370	broad.mit.edu	37	3	186570910	186570910	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:186570910G>A	ENST00000412955.2	+	2	204	c.63G>A	c.(61-63)acG>acA	p.T21T	ADIPOQ_ENST00000444204.2_Silent_p.T21T|ADIPOQ-AS1_ENST00000422718.1_RNA|ADIPOQ_ENST00000320741.2_Silent_p.T21T			Q15848	ADIPO_HUMAN	adiponectin, C1Q and collagen domain containing	21					brown fat cell differentiation|cellular response to drug|cellular response to insulin stimulus|detection of oxidative stress|fatty acid beta-oxidation|generation of precursor metabolites and energy|glucose homeostasis|glucose metabolic process|low-density lipoprotein particle clearance|negative regulation of blood pressure|negative regulation of DNA biosynthetic process|negative regulation of ERK1 and ERK2 cascade|negative regulation of eukaryotic cell surface binding|negative regulation of fat cell differentiation|negative regulation of gluconeogenesis|negative regulation of granulocyte differentiation|negative regulation of heterotypic cell-cell adhesion|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of intracellular protein transport|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|negative regulation of macrophage differentiation|negative regulation of MAP kinase activity|negative regulation of phagocytosis|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein autophosphorylation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|negative regulation of synaptic transmission|negative regulation of transcription, DNA-dependent|negative regulation of tumor necrosis factor production|negative regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of cAMP-dependent protein kinase activity|positive regulation of cholesterol efflux|positive regulation of fatty acid metabolic process|positive regulation of glucose import|positive regulation of glycogen (starch) synthase activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of metanephric glomerular visceral epithelial cell development|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myeloid cell apoptosis|positive regulation of protein kinase A signaling cascade|positive regulation of renal albumin absorption|protein homooligomerization|protein localization in plasma membrane|response to glucose stimulus|response to tumor necrosis factor	collagen|endoplasmic reticulum|extracellular space	cytokine activity|eukaryotic cell surface binding|hormone activity|protein homodimerization activity			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|skin(2)	16	all_cancers(143;1.2e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.47e-19)	GBM - Glioblastoma multiforme(93;0.0776)		AGGAAACCACGACTCAAGGGC	0.627000													29	27					0	0	1	0	0
LCE1D	353134	broad.mit.edu	37	1	152770383	152770383	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:152770383C>T	ENST00000326233.6	+	2	156	c.113C>T	c.(112-114)tCc>tTc	p.S38F		NM_178352.2	NP_848129.1	Q5T752	LCE1D_HUMAN	late cornified envelope 1D	38	Cys-rich.				cellular response to calcium ion|keratinization	cornified envelope|perinuclear region of cytoplasm				large_intestine(1)	1	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCAGTCTCTTCCTGCTGCAGT	0.667000													45	7					0	0	1	0	0
LILRA2	11027	broad.mit.edu	37	19	55086453	55086453	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:55086453C>T	ENST00000251377.3	+	5	741	c.608C>T	c.(607-609)cCc>cTc	p.P203L	LILRA2_ENST00000391738.3_Missense_Mutation_p.P203L|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000448689.1_Intron|LILRB1_ENST00000396321.2_Intron|LILRA2_ENST00000391737.1_Missense_Mutation_p.P191L|LILRA2_ENST00000251376.3_Missense_Mutation_p.P203L					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2											breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		TCGAACTCTCCCTATGTGTGG	0.582000													32	92					0	0	1	0	0
ZNF157	7712	broad.mit.edu	37	X	47272283	47272283	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:47272283G>A	ENST00000377073.3	+	4	897	c.811G>A	c.(811-813)Gag>Aag	p.E271K		NM_003446.3	NP_003437.2	P51786	ZN157_HUMAN	zinc finger protein 157	271					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	11						TCACACAGGGGAGAAACCCTA	0.433000													7	12					0	0	1	0	0
SLC6A17	388662	broad.mit.edu	37	1	110740902	110740902	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:110740902C>T	ENST00000331565.4	+	12	2505	c.2020C>T	c.(2020-2022)Cgc>Tgc	p.R674C		NM_001010898.2	NP_001010898.1	Q9H1V8	S6A17_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 17	674					alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			breast(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	37		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		CGATGAGACCCGCTTCATCCT	0.607000													13	25					0	0	1	0	0
KRT81	3887	broad.mit.edu	37	12	52681465	52681465	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:52681465G>A	ENST00000327741.5	-	6	1009	c.941C>T	c.(940-942)aCc>aTc	p.T314I	KRT86_ENST00000423955.2_Intron|KRT86_ENST00000544024.1_Intron	NM_002281.3	NP_002272.2	Q14533	KRT81_HUMAN	keratin 81	314	Coil 2.|Rod.					keratin filament	protein binding|structural molecule activity			breast(2)|endometrium(3)|large_intestine(3)|lung(6)|prostate(1)|stomach(1)	16				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCGGCGCAGGGTCTCCCCGTG	0.587000													18	15					0	0	1	0	0
FBXO43	286151	broad.mit.edu	37	8	101157299	101157299	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:101157299T>C	ENST00000428847.2	-	1	381	c.65A>G	c.(64-66)aAg>aGg	p.K22R		NM_001029860.3	NP_001025031.2	Q4G163	FBX43_HUMAN	F-box protein 43	22					meiosis		zinc ion binding			endometrium(1)|kidney(4)|large_intestine(5)|lung(14)|prostate(1)|skin(5)|urinary_tract(1)	31	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			TCTTGAGCTCTTAGATGTCAA	0.338000													4	9					0	0	1	0	0
CYP4F22	126410	broad.mit.edu	37	19	15654797	15654797	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:15654797G>A	ENST00000269703.2	+	9	1154	c.955G>A	c.(955-957)Gaa>Aaa	p.E319K	CYP4F22_ENST00000601005.2_Missense_Mutation_p.E319K	NM_173483.3	NP_775754.2	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 22	319						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			endometrium(6)|large_intestine(9)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|soft_tissue(1)	37						AGATGGAAAGGAACTGTCAGA	0.557000													25	29					0	0	1	0	0
QRSL1	55278	broad.mit.edu	37	6	107102702	107102702	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:107102702C>T	ENST00000369046.4	+	8	1051	c.947C>T	c.(946-948)tCc>tTc	p.S316F		NM_018292.4	NP_060762.3	Q9H0R6	QRSL1_HUMAN	glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1	316					translation		ATP binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor			endometrium(2)|kidney(1)|large_intestine(4)|lung(4)	11	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;0.00768)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.248)	Epithelial(6;0.000334)|all cancers(7;0.00157)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0152)	BRCA - Breast invasive adenocarcinoma(108;0.118)|all cancers(137;0.167)|Epithelial(106;0.176)		ATTGAAGTATCCCTTCCTCAC	0.423000													31	42					0	0	1	0	0
LRRC16B	90668	broad.mit.edu	37	14	24527380	24527380	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:24527380C>T	ENST00000342740.5	+	17	1493	c.1339C>T	c.(1339-1341)Ctc>Ttc	p.L447F	LRRC16B_ENST00000334420.7_5'UTR	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	447										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		GCTTCAGGGCCTCTCCCTCAA	0.657000											OREG0022615	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	15					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52321402	52321402	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:52321402G>A	ENST00000356297.4	-	17	2882	c.2782C>T	c.(2782-2784)Ccc>Tcc	p.P928S	PXDNL_ENST00000543296.1_Missense_Mutation_p.P928S	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	928					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity	p.P127S(1)		NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TTTCCGGAGGGAGGCCAAGGA	0.647000													15	19					0	0	1	0	0
ZNF260	339324	broad.mit.edu	37	19	37005917	37005917	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:37005917C>T	ENST00000523638.1	-	3	1345	c.224G>A	c.(223-225)aGa>aAa	p.R75K	ZNF260_ENST00000592282.1_Missense_Mutation_p.R75K|ZNF260_ENST00000588993.1_Missense_Mutation_p.R75K|ZNF260_ENST00000593142.1_Missense_Mutation_p.R75K	NM_001166036.1|NM_001166037.1|NM_001166038.1	NP_001159508.1|NP_001159509.1|NP_001159510.1	Q3ZCT1	ZN260_HUMAN	zinc finger protein 260	75					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)	15	Esophageal squamous(110;0.162)					TGTGTGACTTCTAAGGTGTAG	0.398000													55	40					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85600096	85600096	+	Missense_Mutation	SNP	G	G	A	rs138848829	by1000genomes	TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:85600096G>A	ENST00000322366.6	-	64	10479	c.10072C>T	c.(10072-10074)Cgg>Tgg	p.R3358W	WDFY3_ENST00000295888.4_Missense_Mutation_p.R3375W			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	3375						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		CTGTAATTCCGCACCTCAATG	0.507000													26	33					0	0	1	0	0
LY75	4065	broad.mit.edu	37	2	160755548	160755548	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:160755548G>A	ENST00000263636.4	-	2	144	c.117C>T	c.(115-117)gtC>gtT	p.V39V	LY75-CD302_ENST00000505052.1_Silent_p.V39V|LY75_ENST00000554112.1_Silent_p.V39V|LY75_ENST00000553424.1_Silent_p.V39V|LY75-CD302_ENST00000504764.1_Silent_p.V39V	NM_002349.3	NP_002340.2			lymphocyte antigen 75											NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(22)|prostate(7)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	59				COAD - Colon adenocarcinoma(177;0.132)		TATTTCCATGGACGATGGTGA	0.507000													20	57					0	0	1	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56702302	56702302	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:56702302G>A	ENST00000586855.2	-	4	956	c.643C>T	c.(643-645)Ccg>Tcg	p.P215S	ZSCAN5B_ENST00000358992.3_Missense_Mutation_p.P215S			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	215					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						TTGGGTCTCGGAGAGTTTGGG	0.502000													25	60					0	0	1	0	0
PQBP1	10084	broad.mit.edu	37	X	48759695	48759695	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:48759695G>A	ENST00000218224.4	+	4	732	c.478G>A	c.(478-480)Gat>Aat	p.D160N	PQBP1_ENST00000447146.2_Missense_Mutation_p.D160N|PQBP1_ENST00000396763.1_Missense_Mutation_p.D160N|PQBP1_ENST00000376566.4_Intron|PQBP1_ENST00000247140.4_Intron|PQBP1_ENST00000473764.1_3'UTR|PQBP1_ENST00000376563.1_Missense_Mutation_p.D160N	NM_005710.2	NP_005701.1	O60828	PQBP1_HUMAN	polyglutamine binding protein 1	160	7 X 2 AA tandem repeats of [DE]-R.|Arg-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|transcription coactivator activity			breast(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(2)	11						CAGGGAACGGGATCGGGACCG	0.622000													7	8					0	0	1	0	0
RBM42	79171	broad.mit.edu	37	19	36128155	36128155	+	Nonsense_Mutation	SNP	A	A	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:36128155A>T	ENST00000262633.4	+	9	1336	c.1231A>T	c.(1231-1233)Aag>Tag	p.K411*	RBM42_ENST00000588161.1_Nonsense_Mutation_p.K381*|RBM42_ENST00000589871.1_Nonsense_Mutation_p.K389*|RBM42_ENST00000360475.4_Nonsense_Mutation_p.K382*|RBM42_ENST00000589559.1_Intron|RBM42_ENST00000586618.1_Nonsense_Mutation_p.K115*|RBM42_ENST00000592202.1_Nonsense_Mutation_p.K357*	NM_024321.3	NP_077297.2	Q9BTD8	RBM42_HUMAN	RNA binding motif protein 42	411	Necessary for interaction with HNRNPK (By similarity).|RRM.					cytoplasm|nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(3)|large_intestine(7)|lung(9)|prostate(1)	21	all_lung(56;1.58e-07)|Lung NSC(56;2.43e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CCTTAAGGCCAAGGTGATCCG	0.582000													25	19					0	0	1	0	0
ABCC1	4363	broad.mit.edu	37	16	16142124	16142124	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr16:16142124C>T	ENST00000399408.2	+	10	1519	c.1344C>T	c.(1342-1344)ccC>ccT	p.P448P	ABCC1_ENST00000346370.5_Silent_p.P448P|ABCC1_ENST00000351154.5_Silent_p.P448P|ABCC1_ENST00000349029.5_Silent_p.P448P|ABCC1_ENST00000399410.3_Silent_p.P448P|ABCC1_ENST00000345148.5_Silent_p.P448P			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	448	ABC transmembrane type-1 1.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GGTCAGCCCCCCTGCAAGTCA	0.552000													9	38					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140262838	140262838	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:140262838C>T	ENST00000289272.2	+	1	985	c.985C>T	c.(985-987)Cca>Tca	p.P329S	PCDHA6_ENST00000529310.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA13_ENST00000409494.1_Missense_Mutation_p.P329S|PCDHA9_ENST00000532602.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGAAATATTCCAATGGCGGG	0.398000													11	31					0	0	1	0	0
KRT31	3881	broad.mit.edu	37	17	39553645	39553645	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:39553645C>A	ENST00000251645.2	-	1	199	c.147G>T	c.(145-147)gaG>gaT	p.E49D		NM_002277.2	NP_002268.2	Q15323	K1H1_HUMAN	keratin 31	49	Head.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	31		Breast(137;0.000496)				TGAAGGAGCCCTCGCAGAACC	0.647000													4	68					1	1	1	1	0
ZNF790	388536	broad.mit.edu	37	19	37309404	37309404	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:37309404C>T	ENST00000356725.4	-	5	1962	c.1842G>A	c.(1840-1842)gaG>gaA	p.E614E	CTD-2162K18.5_ENST00000587278.1_RNA|CTD-2162K18.5_ENST00000588906.1_RNA	NM_001242802.1|NM_206894.3	NP_001229731.1|NP_996777.2	Q6PG37	ZN790_HUMAN	zinc finger protein 790	614					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			biliary_tract(1)|endometrium(2)|kidney(2)|large_intestine(14)|lung(7)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	32	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			CATAGGATTTCTCAAAAGTGT	0.323000													28	25					0	0	1	0	0
IGHM	3507	broad.mit.edu	37	14	106320606	106320606	+	RNA	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:106320606C>T	ENST00000390559.2	-	0	1203																											CATTCCTCTTCGGACACGGTC	0.652000													12	20					0	0	1	0	0
MAGEA11	4110	broad.mit.edu	37	X	148797547	148797547	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:148797547G>A	ENST00000355220.5	+	5	503	c.401G>A	c.(400-402)gGc>gAc	p.G134D	MAGEA11_ENST00000333104.4_Missense_Mutation_p.G105D	NM_005366.4	NP_005357.2	P43364	MAGAB_HUMAN	melanoma antigen family A, 11	134						cytoplasm|nucleus	protein binding			cervix(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	9	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					GAAGACCTGGGCCTGGTGGGT	0.572000													18	9					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71743363	71743363	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:71743363C>G	ENST00000258104.3	+	8	1123	c.846C>G	c.(844-846)atC>atG	p.I282M	DYSF_ENST00000410020.3_Missense_Mutation_p.I314M|DYSF_ENST00000409582.3_Missense_Mutation_p.I313M|DYSF_ENST00000409744.1_Missense_Mutation_p.I283M|DYSF_ENST00000409366.1_Missense_Mutation_p.I283M|DYSF_ENST00000394120.2_Missense_Mutation_p.I283M|DYSF_ENST00000429174.2_Missense_Mutation_p.I282M|DYSF_ENST00000409762.1_Missense_Mutation_p.I313M|DYSF_ENST00000410041.1_Missense_Mutation_p.I314M|DYSF_ENST00000409651.1_Missense_Mutation_p.I314M|DYSF_ENST00000413539.2_Missense_Mutation_p.I313M	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	282	C2 2.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						ATGAGCCCATCTTTATCACGG	0.488000													12	19					0	0	1	0	0
FOXG1	2290	broad.mit.edu	37	14	29237522	29237522	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:29237522C>T	ENST00000382535.3	+	2	1406	c.1037C>T	c.(1036-1038)aCt>aTt	p.T346I	FOXG1_ENST00000313071.4_Missense_Mutation_p.T346I			P55316	FOXG1_HUMAN	forkhead box G1	346					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(2)	43			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		TCCGTGTTGACTCAGAACTCG	0.647000													49	63					0	0	1	0	0
DHRS4	10901	broad.mit.edu	37	14	24435492	24435492	+	Splice_Site	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:24435492G>A	ENST00000313250.5	+	6	735	c.531_splice	c.e6-1	p.G178_splice	DHRS4_ENST00000382761.3_Intron|DHRS4_ENST00000308178.8_Intron|DHRS4_ENST00000397073.2_Intron|DHRS4_ENST00000421831.1_Splice_Site_p.G126_splice|DHRS4_ENST00000558263.1_Intron|DHRS4_ENST00000397075.3_Intron|DHRS4_ENST00000558581.1_Splice_Site_p.G144_splice|DHRS4_ENST00000543741.2_Intron|DHRS4_ENST00000397074.3_Intron|DHRS4_ENST00000559632.1_Intron	NM_021004.2	NP_066284.2	Q9BTZ2	DHRS4_HUMAN	dehydrogenase/reductase (SDR family) member 4	178						mitochondrion|nuclear membrane|peroxisome	binding|carbonyl reductase (NADPH) activity			central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14				GBM - Glioblastoma multiforme(265;0.00962)	Vitamin A(DB00162)	CTTTCTCCAGGGCTTCAGTCC	0.478000													20	47					0	0	1	0	0
TPRA1	131601	broad.mit.edu	37	3	127298867	127298867	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:127298867G>A	ENST00000355552.3	-	2	499	c.123C>T	c.(121-123)tcC>tcT	p.S41S	TPRA1_ENST00000489960.1_Silent_p.S41S|TPRA1_ENST00000296210.7_Silent_p.S41S|TPRA1_ENST00000450633.2_Silent_p.S41S	NM_001136053.1	NP_001129525.1	Q86W33	TPRA1_HUMAN	transmembrane protein, adipocyte asscociated 1	41					aging|lipid metabolic process	integral to membrane	G-protein coupled receptor activity			endometrium(2)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	9						TGCCTCACCTGGAGGTGCCAA	0.612000													24	40					0	0	1	0	0
ABCC1	4363	broad.mit.edu	37	16	16142123	16142123	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr16:16142123C>T	ENST00000399408.2	+	10	1518	c.1343C>T	c.(1342-1344)cCc>cTc	p.P448L	ABCC1_ENST00000346370.5_Missense_Mutation_p.P448L|ABCC1_ENST00000351154.5_Missense_Mutation_p.P448L|ABCC1_ENST00000349029.5_Missense_Mutation_p.P448L|ABCC1_ENST00000399410.3_Missense_Mutation_p.P448L|ABCC1_ENST00000345148.5_Missense_Mutation_p.P448L			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	448	ABC transmembrane type-1 1.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TGGTCAGCCCCCCTGCAAGTC	0.547000													9	39					0	0	1	0	0
KCTD21	283219	broad.mit.edu	37	11	77885272	77885272	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:77885272G>A	ENST00000340067.3	-	2	607	c.329C>T	c.(328-330)gCc>gTc	p.A110V	KCTD21-AS1_ENST00000600795.1_RNA	NM_001029859.1	NP_001025030.1	Q4G0X4	KCD21_HUMAN	potassium channel tetramerization domain containing 21	110						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|endometrium(1)|large_intestine(4)|lung(2)|pancreas(1)|prostate(2)	11	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.46e-24)			GTTGAGCATGGCATTCTTCTC	0.602000													19	24					0	0	1	0	0
HNRNPLL	92906	broad.mit.edu	37	2	38800437	38800437	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:38800437A>G	ENST00000449105.2	-	8	1346	c.1007T>C	c.(1006-1008)gTt>gCt	p.V336A	HNRNPLL_ENST00000409636.1_Missense_Mutation_p.V331A|HNRNPLL_ENST00000409328.1_Missense_Mutation_p.V302A|HNRNPLL_ENST00000378915.3_Missense_Mutation_p.V302A	NM_138394.3	NP_612403.2			heterogeneous nuclear ribonucleoprotein L-like																		AACCATTACAACTGAACCAGA	0.388000													16	14					0	0	1	0	0
TC2N	123036	broad.mit.edu	37	14	92251698	92251698	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:92251698G>A	ENST00000435962.2	-	11	1493	c.1170C>T	c.(1168-1170)ttC>ttT	p.F390F	TC2N_ENST00000360594.5_Silent_p.F390F|TC2N_ENST00000556018.1_Silent_p.F326F|TC2N_ENST00000340892.5_Silent_p.F390F	NM_001128596.1	NP_001122068.1	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	390	C2.					nucleus				breast(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(5)|skin(1)|upper_aerodigestive_tract(2)	18				COAD - Colon adenocarcinoma(157;0.218)		CCACCTTCACGAAAAAACCTA	0.323000													52	65					0	0	1	0	0
PLA2G2E	30814	broad.mit.edu	37	1	20248868	20248868	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:20248868C>T	ENST00000375116.3	-	3	266	c.209G>A	c.(208-210)gGg>gAg	p.G70E		NM_014589.1	NP_055404.1	Q9NZK7	PA2GE_HUMAN	phospholipase A2, group IIE	70					inflammatory response|lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			breast(1)|endometrium(1)|large_intestine(1)|lung(6)|urinary_tract(1)	10		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|GBM - Glioblastoma multiforme(114;0.000146)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CTCCAGACGCCCGTAGCAGCA	0.607000													10	7					0	0	1	0	0
FAM105B	90268	broad.mit.edu	37	5	14687733	14687733	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:14687733C>T	ENST00000284274.4	+	5	650	c.572C>T	c.(571-573)tCc>tTc	p.S191F		NM_138348.4	NP_612357.4	Q96BN8	F105B_HUMAN	family with sequence similarity 105, member B	191										breast(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)	14	Lung NSC(4;0.00696)					ATTAAAGAGTCCCTTACTCTG	0.423000													28	49					0	0	1	0	0
HERC2P2	400322	broad.mit.edu	37	15	23335584	23335584	+	RNA	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:23335584G>A	ENST00000560464.1	-	0	556																											TCGTTATTATGGTTCTCCAAA	0.368000													8	31					0	0	1	0	0
ERCC6	2074	broad.mit.edu	37	10	50686468	50686468	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:50686468G>A	ENST00000355832.5	-	11	2296	c.2218C>T	c.(2218-2220)Cca>Tca	p.P740S	ERCC6_ENST00000542458.1_Missense_Mutation_p.P110S	NM_000124.2	NP_000115.1	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6	740					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			breast(5)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						AGTAGGTATGGATTTATGGTA	0.388000								Direct reversal of damage;Nucleotide excision repair (NER)					25	71					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27202969	27202969	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:27202969G>A	ENST00000380036.4	+	13	2503	c.2061G>A	c.(2059-2061)gtG>gtA	p.V687V	TEK_ENST00000519097.1_Silent_p.V540V|TEK_ENST00000406359.4_Silent_p.V644V	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	687	Fibronectin type-III 3.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		ACGTTGATGTGAAGATAAAGA	0.423000													41	25					0	0	1	0	0
CPA1	1357	broad.mit.edu	37	7	130025062	130025062	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:130025062C>T	ENST00000011292.3	+	8	1013	c.863C>T	c.(862-864)tCc>tTc	p.S288F	CPA1_ENST00000484324.1_Missense_Mutation_p.S200F	NM_001868.2	NP_001859.1	P15085	CBPA1_HUMAN	carboxypeptidase A1 (pancreatic)	288					proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)	21	Melanoma(18;0.0435)					GAGGTCAAGTCCATTGTAGAC	0.537000													25	26					0	0	1	0	0
TSSC4	10078	broad.mit.edu	37	11	2424529	2424529	+	Silent	SNP	C	C	T	rs61741006		TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:2424529C>T	ENST00000333256.6	+	3	1109	c.666C>T	c.(664-666)gtC>gtT	p.V222V	TSSC4_ENST00000380992.1_Intron|TSSC4_ENST00000451491.2_Silent_p.V222V|TSSC4_ENST00000380996.5_Silent_p.V158V|TSSC4_ENST00000467308.1_Intron			Q9Y5U2	TSSC4_HUMAN	tumor suppressing subtransferable candidate 4	222										endometrium(3)|large_intestine(1)|lung(4)	8		all_epithelial(84;0.000161)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.0137)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.00145)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCCGAGGGGTCGAAGCCAGAC	0.657000													10	19					0	0	1	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24253304	24253304	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:24253304G>A	ENST00000538205.1	+	6	745	c.198G>A	c.(196-198)ggG>ggA	p.G66G	RP11-624C23.1_ENST00000523578.1_RNA|ADAMDEC1_ENST00000256412.4_Silent_p.G145G|RP11-624C23.1_ENST00000519689.1_RNA|ADAMDEC1_ENST00000522298.1_Silent_p.G66G	NM_001145271.1	NP_001138743.1	O15204	ADEC1_HUMAN	ADAM-like, decysin 1	145					integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|large_intestine(4)|skin(2)|stomach(1)	9		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		CTTGTGACGGGTTGAGGTAAG	0.343000													12	25					0	0	1	0	0
DNAI2	64446	broad.mit.edu	37	17	72285743	72285743	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:72285743G>A	ENST00000579490.1	+	4	784	c.649G>A	c.(649-651)Gaa>Aaa	p.E217K	DNAI2_ENST00000311014.6_Missense_Mutation_p.E160K|DNAI2_ENST00000307504.5_Missense_Mutation_p.E17K|DNAI2_ENST00000582036.1_Missense_Mutation_p.E160K|DNAI2_ENST00000446837.2_Missense_Mutation_p.E160K			Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate chain 2	160					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(2)|lung(19)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						GGACCCCCAGGAAATCAAGAG	0.552000									Kartagener syndrome				8	33					0	0	1	0	0
TECTB	6975	broad.mit.edu	37	10	114044355	114044355	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:114044355G>A	ENST00000369422.3	+	2	139	c.139G>A	c.(139-141)Gga>Aga	p.G47R		NM_058222.1	NP_478129.1	Q96PL2	TECTB_HUMAN	tectorin beta	47	ZP.					anchored to membrane|plasma membrane|proteinaceous extracellular matrix				kidney(2)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	19		Colorectal(252;0.198)		Epithelial(162;0.0143)|all cancers(201;0.0242)		GTGTCCCTATGGATGGGAAGT	0.443000													5	14					0	0	1	0	0
OR5AK2	390181	broad.mit.edu	37	11	56757303	56757303	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:56757303G>A	ENST00000326855.2	+	1	957	c.915G>A	c.(913-915)ggG>ggA	p.G305G		NM_001005323.1	NP_001005323.1	Q8NH90	O5AK2_HUMAN	olfactory receptor, family 5, subfamily AK, member 2	305					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	21						AAGTGATAGGGAAAAAGTTAT	0.303000													6	9					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168838922	168838922	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:168838922C>T	ENST00000464456.1	-	6	1690	c.490G>A	c.(490-492)Gag>Aag	p.E164K	MECOM_ENST00000468789.1_Missense_Mutation_p.E164K|MECOM_ENST00000433243.2_Missense_Mutation_p.E165K|MECOM_ENST00000264674.3_Missense_Mutation_p.E229K|MECOM_ENST00000494292.1_Missense_Mutation_p.E352K|MECOM_ENST00000472280.1_Missense_Mutation_p.E165K|MECOM_ENST00000392736.3_Missense_Mutation_p.E164K|MECOM_ENST00000460814.1_Missense_Mutation_p.E164K	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						TTGCCACACTCCGGGCATGCA	0.527000													7	13					0	0	1	0	0
ZIK1	284307	broad.mit.edu	37	19	58102227	58102227	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:58102227C>T	ENST00000597850.1	+	4	1263	c.1048C>T	c.(1048-1050)Cct>Tct	p.P350S	ZIK1_ENST00000599456.1_Missense_Mutation_p.P295S|ZIK1_ENST00000307468.4_3'UTR|ZIK1_ENST00000536878.2_Missense_Mutation_p.P337S	NM_001010879.2	NP_001010879.2	Q3SY52	ZIK1_HUMAN	zinc finger protein interacting with K protein 1	350					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	34		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TGGAGAAAGGCCTTATAAGTG	0.448000													27	30					0	0	1	0	0
FOXJ3	22887	broad.mit.edu	37	1	42744051	42744051	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:42744051G>A	ENST00000372572.1	-	5	648	c.337C>T	c.(337-339)Cca>Tca	p.P113S	FOXJ3_ENST00000372573.1_Missense_Mutation_p.P113S|FOXJ3_ENST00000361346.1_Missense_Mutation_p.P113S|FOXJ3_ENST00000545068.1_Missense_Mutation_p.P113S|FOXJ3_ENST00000361776.1_Missense_Mutation_p.P113S	NM_001198851.1	NP_001185780.1	Q9UPW0	FOXJ3_HUMAN	forkhead box J3	113					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	18	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CTATAATATGGGAAGTTATCA	0.313000													22	26					0	0	1	0	0
C19orf80	55908	broad.mit.edu	37	19	11350541	11350541	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:11350541C>T	ENST00000252453.8	+	1	247	c.228C>T	c.(226-228)ctC>ctT	p.L76L	DOCK6_ENST00000294618.7_Intron|C19orf80_ENST00000591200.1_Intron	NM_018687.6	NP_061157.3	Q6UXH0	TD26_HUMAN	chromosome 19 open reading frame 80	76						extracellular region				NS(1)|breast(1)|endometrium(2)	4						CAATAGAACTCCTGGGGCAGG	0.647000													4	9					0	0	1	0	0
LMAN1	3998	broad.mit.edu	37	18	56998709	56998709	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr18:56998709G>A	ENST00000251047.5	-	12	2154	c.1437C>T	c.(1435-1437)gtC>gtT	p.V479V		NM_005570.3	NP_005561.1	P49257	LMAN1_HUMAN	lectin, mannose-binding, 1	479					blood coagulation|ER to Golgi vesicle-mediated transport|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	mannose binding|metal ion binding|unfolded protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16		Colorectal(73;0.0946)			Antihemophilic Factor(DB00025)	TAATGAAGTGGACCGTAGACA	0.348000													13	18					0	0	1	0	0
ANKRD50	57182	broad.mit.edu	37	4	125593259	125593259	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:125593259G>A	ENST00000504087.1	-	4	2210	c.1173C>T	c.(1171-1173)atC>atT	p.I391I	ANKRD50_ENST00000515641.1_Silent_p.I212I	NM_020337.2	NP_065070.1	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	391										NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(14)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	55						GTTTGGAGAGGATATCTAACT	0.393000													43	36					0	0	1	0	0
TAAR6	319100	broad.mit.edu	37	6	132891549	132891549	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:132891549G>A	ENST00000275198.1	+	1	89	c.89G>A	c.(88-90)gGa>gAa	p.G30E		NM_175067.1	NP_778237.1	Q96RI8	TAAR6_HUMAN	trace amine associated receptor 6	30						plasma membrane	G-protein coupled receptor activity			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(19)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.006)|GBM - Glioblastoma multiforme(226;0.00792)		TTCTCGCCGGGATCCCGGGTG	0.517000													33	36					0	0	1	0	0
PSMB9	5698	broad.mit.edu	37	6	32826288	32826288	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:32826288C>T	ENST00000453265.2	+	4	475	c.406C>T	c.(406-408)Cag>Tag	p.Q136*	PSMB9_ENST00000374859.2_Intron|PSMB9_ENST00000395330.1_Intron			P28065	PSB9_HUMAN	proteasome (prosome, macropain) subunit, beta type, 9	0					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			large_intestine(4)|lung(4)|skin(1)	9						AGACGGTAACCAGCCAAGTGG	0.507000													6	17					0	0	1	0	0
PPBPP2	10895	broad.mit.edu	37	4	74919832	74919832	+	RNA	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:74919832C>T	ENST00000513150.1	-	0	1284					NR_026769.1																						ATTTTTTCTCCCATCTTACAG	0.398000													5	6					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141727420	141727420	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:141727420G>A	ENST00000475668.2	+	10	1160	c.1106G>A	c.(1105-1107)cGg>cAg	p.R369Q	MGAM_ENST00000549489.2_Missense_Mutation_p.R369Q			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	369	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CTCATTGGGCGGCCAGCCCTT	0.428000													19	14					0	0	1	0	0
PTGER3	5733	broad.mit.edu	37	1	71512400	71512400	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:71512400G>A	ENST00000370924.4	-	1	1091	c.861C>T	c.(859-861)atC>atT	p.I287I	PTGER3_ENST00000356595.4_Silent_p.I287I|PTGER3_ENST00000370932.2_Silent_p.I287I|PTGER3_ENST00000370931.3_Silent_p.I287I|PTGER3_ENST00000306666.5_Silent_p.I287I|PTGER3_ENST00000351052.5_Silent_p.I287I|PTGER3_ENST00000354608.5_Silent_p.I287I|PTGER3_ENST00000460330.1_Silent_p.I287I|PTGER3_ENST00000414819.1_Silent_p.I287I	NM_198715.2	NP_942008.1	P43115	PE2R3_HUMAN	prostaglandin E receptor 3 (subtype EP3)	287					cell death|positive regulation of fever generation|transcription, DNA-dependent	integral to plasma membrane|nuclear envelope	ligand-dependent nuclear receptor activity|prostaglandin E receptor activity	p.I287I(5)		endometrium(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	25					Bimatoprost(DB00905)	GCACGCACATGATCCCCATAA	0.627000													14	24					0	0	1	0	0
STAT1	6772	broad.mit.edu	37	2	191848401	191848401	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:191848401G>A	ENST00000361099.3	-	17	1800	c.1413C>T	c.(1411-1413)atC>atT	p.I471I	STAT1_ENST00000392323.2_Silent_p.I473I|STAT1_ENST00000392322.3_Silent_p.I471I|STAT1_ENST00000540176.1_3'UTR|STAT1_ENST00000409465.1_Silent_p.I471I	NM_007315.3	NP_009330.1	P42224	STAT1_HUMAN	signal transducer and activator of transcription 1, 91kDa	471					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	TGTACCAAAGGATGGAGGCCC	0.532000													14	56					0	0	1	0	0
PQLC2	54896	broad.mit.edu	37	1	19651188	19651188	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:19651188C>T	ENST00000375153.3	+	3	866	c.226C>T	c.(226-228)Ctg>Ttg	p.L76L	PQLC2_ENST00000400548.2_Silent_p.L11L|PQLC2_ENST00000375155.3_Silent_p.L76L	NM_001040125.1	NP_001035214.1	Q6ZP29	PQLC2_HUMAN	PQ loop repeat containing 2	76	PQ-loop 1.					integral to membrane				haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|skin(1)|urinary_tract(1)	10		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;1.89e-05)|Kidney(64;0.000177)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GTGGTTCCTCCTGGGCTGGAT	0.622000													26	31					0	0	1	0	0
SGMS1	259230	broad.mit.edu	37	10	52103296	52103296	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:52103296G>A	ENST00000361781.2	-	7	1538	c.579C>T	c.(577-579)atC>atT	p.I193I	SGMS1_ENST00000429490.1_Intron|SGMS1_ENST00000361543.2_Silent_p.I193I	NM_147156.3	NP_671512.1	Q86VZ5	SMS1_HUMAN	sphingomyelin synthase 1	199					apoptosis|cell growth|sphingomyelin biosynthetic process	endoplasmic reticulum|Golgi trans cisterna|integral to Golgi membrane|nucleus|plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	16						GTCCTACAAGGATCATGCCAT	0.408000													14	10					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176934324	176934324	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:176934324C>T	ENST00000367654.2	-	9	1610	c.1597G>A	c.(1597-1599)Gag>Aag	p.E533K	ASTN1_ENST00000424564.2_Missense_Mutation_p.E525K|ASTN1_ENST00000361833.2_Missense_Mutation_p.E525K|ASTN1_ENST00000281881.3_5'UTR|ASTN1_ENST00000367657.3_Missense_Mutation_p.E525K			O14525	ASTN1_HUMAN	astrotactin 1	533					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						GAGGGCTGCTCTCCCAAAACC	0.423000													19	26					0	0	1	0	0
COL6A1	1291	broad.mit.edu	37	21	47414120	47414120	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr21:47414120C>T	ENST00000361866.3	+	20	1489	c.1375C>T	c.(1375-1377)Ccc>Tcc	p.P459S		NM_001848.2	NP_001839.2	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1	459	Triple-helical region.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	AAGAGAAGGCCCCGTTGGTGT	0.637000													3	11					0	0	1	0	0
FMNL1	752	broad.mit.edu	37	17	43323271	43323271	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:43323271G>A	ENST00000331495.3	+	24	3357	c.3021G>A	c.(3019-3021)tgG>tgA	p.W1007*	CTD-2020K17.4_ENST00000420431.2_RNA|FMNL1_ENST00000587489.1_Nonsense_Mutation_p.W585*|FMNL1_ENST00000328118.3_Nonsense_Mutation_p.W1007*	NM_005892.3	NP_005883.2	O95466	FMNL_HUMAN	formin-like 1	1007	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(12)|pancreas(1)|skin(1)|urinary_tract(2)	33						TGGAACAGTGGAAAAAAGAAG	0.632000													8	12					0	0	1	0	0
LILRA2	11027	broad.mit.edu	37	19	55085884	55085884	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:55085884G>A	ENST00000251377.3	+	4	320	c.187G>A	c.(187-189)Gaa>Aaa	p.E63K	LILRA2_ENST00000391738.3_Missense_Mutation_p.E63K|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000448689.1_Intron|LILRB1_ENST00000396321.2_Intron|LILRA2_ENST00000391737.1_Missense_Mutation_p.E51K|LILRA2_ENST00000251376.3_Missense_Mutation_p.E63K|LILRA2_ENST00000495786.1_3'UTR					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2											breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		TCTATATAGGGAAAACAAATC	0.557000													41	18					0	0	1	0	0
SLC30A9	10463	broad.mit.edu	37	4	42041010	42041010	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:42041010C>T	ENST00000264451.6	+	8	857	c.677C>T	c.(676-678)tCc>tTc	p.S226F		NM_006345.3	NP_006336.3	Q6PML9	ZNT9_HUMAN	solute carrier family 30 (zinc transporter), member 9	226					nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						CAGCCACGCTCCAGAACAGCA	0.358000													17	30					0	0	1	0	0
PIK3R5	23533	broad.mit.edu	37	17	8792192	8792192	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:8792192G>A	ENST00000447110.1	-	10	1036	c.912C>T	c.(910-912)atC>atT	p.I304I	PIK3R5_ENST00000581552.1_Silent_p.I304I|PIK3R5_ENST00000584803.1_Silent_p.I304I	NM_001142633.2|NM_001251851.1|NM_001251852.1|NM_001251853.1|NM_001251855.1	NP_001136105.1|NP_001238780.1|NP_001238781.1|NP_001238782.1|NP_001238784.1	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	304				DILQEILLKEQELLQPGILGDDEEEEEEEEEVEEDLETDGH CAERDSLLSTSSLASHDSTLSLASSQASG -> GNIEGDPG PRRPDSAGLASLQTSCRKSCSRNRSYSSQGSWEMMKRRERR RRRWRRTWKLTGTVPREIPCS (in Ref. 6; AAW63121).	platelet activation	cytosol|membrane|nucleus				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(14)|prostate(3)|skin(4)|urinary_tract(1)	34						CCTTGAGCAGGATTTCCTGCA	0.582000													7	18					0	0	1	0	0
TCEB3B	51224	broad.mit.edu	37	18	44560486	44560486	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr18:44560486C>T	ENST00000332567.4	-	1	1502	c.1150G>A	c.(1150-1152)Gaa>Aaa	p.E384K	KATNAL2_ENST00000592005.1_Intron|KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000245121.5_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	384					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						AGGTATTTTTCACATGACAGA	0.488000													24	38					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167495	140167495	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:140167495G>A	ENST00000504120.2	+	1	1620	c.1620G>A	c.(1618-1620)gcG>gcA	p.A540A	PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000378133.3_Silent_p.A540A	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCGGGATGCGGGCGTGCCGC	0.682000													40	80					0	0	1	0	0
PLCB2	5330	broad.mit.edu	37	15	40589767	40589767	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:40589767C>T	ENST00000260402.3	-	13	1527	c.1278G>A	c.(1276-1278)acG>acA	p.T426T	PLCB2_ENST00000456256.2_Silent_p.T426T|PLCB2_ENST00000557821.1_Silent_p.T426T	NM_004573.2	NP_004564.2	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	426	PI-PLC X-box.				activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity	p.T426T(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(3)	39		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		CCCCAAAGATCGTCCGGCAAT	0.597000													16	16					0	0	1	0	0
FSIP1	161835	broad.mit.edu	37	15	39910028	39910028	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:39910028G>A	ENST00000350221.3	-	11	1816	c.1607C>T	c.(1606-1608)tCc>tTc	p.S536F		NM_152597.4	NP_689810.3	Q8NA03	FSIP1_HUMAN	fibrous sheath interacting protein 1	536								p.S536F(1)		NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(4)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	23		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)		ATCTAAGAAGGAGGGCCTTTT	0.403000													18	53					0	0	1	0	0
ITPKB	3707	broad.mit.edu	37	1	226925114	226925114	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:226925114T>C	ENST00000429204.1	-	2	373	c.46A>G	c.(46-48)Agc>Ggc	p.S16G	ITPKB_ENST00000272117.3_Missense_Mutation_p.S16G|ITPKB_ENST00000366784.1_Missense_Mutation_p.S16G	NM_002221.3	NP_002212.3	P27987	IP3KB_HUMAN	inositol-trisphosphate 3-kinase B	16							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(4)|prostate(1)|skin(1)	30		Prostate(94;0.0773)				TCGTTGGCGCTATTCATGATC	0.701000													15	14					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53092785	53092785	+	Silent	SNP	T	T	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:53092785T>C	ENST00000276480.7	-	9	857	c.174A>G	c.(172-174)ctA>ctG	p.L58L		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	58						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				GGGGCTTCATTAGCAGGGATT	0.507000													28	64					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54661851	54661851	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:54661851G>A	ENST00000474759.1	+	10	1049	c.1001G>A	c.(1000-1002)gGa>gAa	p.G334E	CACNA2D3_ENST00000288197.5_Missense_Mutation_p.G334E|CACNA2D3_ENST00000490478.1_Missense_Mutation_p.G240E|CACNA2D3_ENST00000415676.2_Missense_Mutation_p.G334E	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	334	VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TTCGCCAAAGGAATTGGAATG	0.418000													6	2					0	0	1	0	0
SASH1	23328	broad.mit.edu	37	6	148711386	148711386	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:148711386G>A	ENST00000367467.3	+	2	748	c.273G>A	c.(271-273)caG>caA	p.Q91Q	SASH1_ENST00000367469.1_Silent_p.Q46Q	NM_015278.3	NP_056093.3	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	91							protein binding			breast(4)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		GGGTTTCCCAGGACCTGGAAG	0.537000													10	12					0	0	1	0	0
PDZK1IP1	10158	broad.mit.edu	37	1	47655565	47655565	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:47655565C>T	ENST00000294338.2	-	1	162	c.40G>A	c.(40-42)Gca>Aca	p.A14T	PDZK1IP1_ENST00000371885.1_Missense_Mutation_p.A14T	NM_005764.3	NP_005755.1	Q13113	PDZ1I_HUMAN	PDZK1 interacting protein 1	14						integral to membrane				endometrium(1)|lung(1)|prostate(1)	3						GGTGGCACTGCCGTGAGCAGG	0.667000													5	10					0	0	1	0	0
FBXO22	26263	broad.mit.edu	37	15	76225224	76225224	+	Silent	SNP	T	T	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:76225224T>C	ENST00000308275.3	+	7	1098	c.993T>C	c.(991-993)ttT>ttC	p.F331F	FBXO22_ENST00000540507.1_Silent_p.F227F	NM_147188.2	NP_671717.1	Q8NEZ5	FBX22_HUMAN	F-box protein 22	331					ubiquitin-dependent protein catabolic process		ubiquitin-protein ligase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21						GCAGGGGCTTTCAGTATTACA	0.468000													20	45					0	0	1	0	0
TLR8	51311	broad.mit.edu	37	X	12938612	12938612	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:12938612G>A	ENST00000218032.6	+	2	1540	c.1453G>A	c.(1453-1455)Gcc>Acc	p.A485T	TLR8_ENST00000311912.5_Missense_Mutation_p.A503T	NM_138636.4	NP_619542.1	Q9NR97	TLR8_HUMAN	toll-like receptor 8	485					cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						TTATGGAAAAGCCTTAGATTT	0.393000													24	31					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16262467	16262467	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:16262467C>T	ENST00000375759.3	+	11	9936	c.9732C>T	c.(9730-9732)acC>acT	p.T3244T		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	3244	Pro-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CTgcccccacccccacccctg	0.672000													11	6					0	0	1	0	0
PLEKHA4	57664	broad.mit.edu	37	19	49360692	49360692	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:49360692G>A	ENST00000263265.6	-	9	1589	c.1034C>T	c.(1033-1035)tCc>tTc	p.S345F	PLEKHA4_ENST00000355496.5_Intron	NM_020904.2	NP_065955.2	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	345	Pro-rich.					cytoplasm|membrane	1-phosphatidylinositol binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	30		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		TAAAACCATGGAGGCCCGGGT	0.562000													7	5					0	0	1	0	0
IL1RL1	9173	broad.mit.edu	37	2	102968048	102968048	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:102968048C>T	ENST00000233954.1	+	11	1609	c.1338C>T	c.(1336-1338)ttC>ttT	p.F446F		NM_016232.4	NP_057316.3	Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1	446	TIR.				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(3)|urinary_tract(1)	16						GGCACATTTTCATCCTGACCC	0.458000													19	15					0	0	1	0	0
EXOC8	149371	broad.mit.edu	37	1	231472294	231472294	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:231472294G>A	ENST00000366645.1	-	1	1304	c.1186C>T	c.(1186-1188)Cca>Tca	p.P396S	EXOC8_ENST00000360394.2_Missense_Mutation_p.P400S			Q8IYI6	EXOC8_HUMAN	exocyst complex component 8	400					exocytosis|protein transport	growth cone|nucleus	protein binding			cervix(2)|endometrium(1)|large_intestine(2)|liver(1)|lung(5)|prostate(1)|skin(1)|stomach(1)	14	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				GAACGATCTGGGGAGAGTTCG	0.542000													15	26					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167496	140167496	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:140167496G>A	ENST00000504120.2	+	1	1621	c.1621G>A	c.(1621-1623)Ggc>Agc	p.G541S	PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000378133.3_Missense_Mutation_p.G541S	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGGGATGCGGGCGTGCCGCC	0.682000													40	80					0	0	1	0	0
MUC3A	4584	broad.mit.edu	37	7	100552303	100552303	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:100552303C>T	ENST00000319509.7	+	1	1054	c.1054C>T	c.(1054-1056)Ccc>Tcc	p.P352S						mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						TACTTCTCCTCCCACCACCCC	0.468000													16	300					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57744476	57744476	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:57744476G>A	ENST00000281282.5	+	6	2121	c.2043G>A	c.(2041-2043)aaG>aaA	p.K681K		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	681						myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		AGCTCCGGAAGAATCTGGAGG	0.498000													10	12					0	0	1	0	0
ERBB4	2066	broad.mit.edu	37	2	212248773	212248773	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:212248773G>A	ENST00000342788.4	-	28	3804	c.3494C>T	c.(3493-3495)cCa>cTa	p.P1165L	ERBB4_ENST00000436443.1_Missense_Mutation_p.P1149L|ERBB4_ENST00000402597.1_Missense_Mutation_p.P1155L	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	1165					cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		CTCCTCCACTGGATTCAGGTA	0.383000										TSP Lung(8;0.080)			25	26					0	0	1	0	0
GBA3	57733	broad.mit.edu	37	4	22729452	22729452	+	RNA	SNP	G	G	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:22729452G>T	ENST00000508166.1	+	0	160				GBA3_ENST00000503442.1_RNA|GBA3_ENST00000511446.1_RNA	NM_020973.4	NP_066024.1	Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						AACTGTGACTGCATAGTTGTC	0.413000													43	53					1.62957e-23	1.67002e-23	1	1	0
ITIH5	80760	broad.mit.edu	37	10	7697616	7697616	+	Missense_Mutation	SNP	T	T	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:7697616T>G	ENST00000256861.6	-	2	191	c.113A>C	c.(112-114)cAa>cCa	p.Q38P	ITIH5_ENST00000397145.2_Missense_Mutation_p.Q38P|ITIH5_ENST00000397146.2_Missense_Mutation_p.Q38P|ITIH5_ENST00000446830.2_5'UTR	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	38	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						CAGTCTGACTTGCCTCGGGAC	0.403000													7	21					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57640963	57640963	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:57640963C>T	ENST00000254181.4	+	4	1374	c.920C>T	c.(919-921)cCa>cTa	p.P307L	USP29_ENST00000598197.1_Missense_Mutation_p.P307L	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	307					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TTTGCAATTCCATCTTTTGCT	0.438000													17	41					0	0	1	0	0
RASSF6	166824	broad.mit.edu	37	4	74453617	74453617	+	Missense_Mutation	SNP	G	G	A	rs142555062		TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:74453617G>A	ENST00000307439.5	-	5	616	c.322C>T	c.(322-324)Cgt>Tgt	p.R108C	RASSF6_ENST00000395777.2_Missense_Mutation_p.R108C|RASSF6_ENST00000342081.3_Missense_Mutation_p.R140C|RASSF6_ENST00000335049.5_Missense_Mutation_p.R96C	NM_001270391.1|NM_177532.4	NP_001257320.1|NP_803876.1	Q6ZTQ3	RASF6_HUMAN	Ras association (RalGDS/AF-6) domain family member 6	140					apoptosis|signal transduction		protein binding	p.R140C(1)		breast(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(4)|pancreas(2)|skin(2)	17	Breast(15;0.00102)		all cancers(17;0.00104)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			TCACTAATACGATAGAGATCG	0.383000													33	27					0	0	1	0	0
KERA	11081	broad.mit.edu	37	12	91449866	91449866	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:91449866C>T	ENST00000266719.3	-	2	440	c.193G>A	c.(193-195)Gaa>Aaa	p.E65K		NM_007035.3	NP_008966.1	O60938	KERA_HUMAN	keratocan	65	LRRNT.				response to stimulus|visual perception	proteinaceous extracellular matrix				breast(2)|large_intestine(8)|lung(5)|prostate(2)|skin(2)	19						GCAGGAATTTCTTTGAGACCT	0.388000													17	21					0	0	1	0	0
SFMBT1	51460	broad.mit.edu	37	3	52940169	52940169	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:52940169G>A	ENST00000394752.3	-	20	2802	c.2420C>T	c.(2419-2421)tCc>tTc	p.S807F	SFMBT1_ENST00000296295.6_Intron|SFMBT1_ENST00000394750.1_Missense_Mutation_p.S807F|SFMBT1_ENST00000358080.2_Missense_Mutation_p.S807F	NM_016329.3	NP_057413.2	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	807	SAM.				regulation of transcription, DNA-dependent	nucleus				breast(2)|endometrium(3)|kidney(3)|large_intestine(8)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	24				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		ACAGTCAGTGGATCTGATGAA	0.413000													23	18					0	0	1	0	0
RFC3	5983	broad.mit.edu	37	13	34410402	34410402	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr13:34410402G>A	ENST00000380071.3	+	9	1171	c.1041G>A	c.(1039-1041)atG>atA	p.M347I	RFC3_ENST00000434425.1_Intron	NM_002915.3	NP_002906.1	P40938	RFC3_HUMAN	replication factor C (activator 1) 3, 38kDa	347					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|response to organophosphorus|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			lung(2)|skin(1)	3		Hepatocellular(188;0.0191)|Lung SC(185;0.0548)		all cancers(112;5.09e-06)|Epithelial(112;6.52e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00107)|OV - Ovarian serous cystadenocarcinoma(117;0.0285)|GBM - Glioblastoma multiforme(144;0.123)		AGAAGTTCATGGAGGATGGAT	0.398000													94	12					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103470339	103470339	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:103470339G>A	ENST00000361246.2	-	4	661	c.373C>T	c.(373-375)Cgc>Tgc	p.R125C		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	125	Protein kinase.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		AGCACATCGCGCTCCTCTCGG	0.627000													8	11					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	62986530	62986530	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:62986530C>T	ENST00000561311.1	+	13	1461	c.1231C>T	c.(1231-1233)Cga>Tga	p.R411*	TLN2_ENST00000306829.6_Nonsense_Mutation_p.R411*			Q9Y4G6	TLN2_HUMAN	talin 2	411					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						AAGTAAAGATCGATTTGGACT	0.448000													6	36					0	0	1	0	0
ZFP64	55734	broad.mit.edu	37	20	50769007	50769007	+	Missense_Mutation	SNP	T	T	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:50769007T>G	ENST00000216923.4	-	6	2073	c.1724A>C	c.(1723-1725)gAg>gCg	p.E575A	ZFP64_ENST00000477786.1_Intron|ZFP64_ENST00000346617.4_Missense_Mutation_p.E521A|ZFP64_ENST00000371518.2_Intron|ZFP64_ENST00000361387.2_Intron|ZFP64_ENST00000371515.4_Missense_Mutation_p.E573A	NM_018197.2|NM_199426.1	NP_060667.2|NP_955458.1	Q9NPA5	ZF64A_HUMAN	ZFP64 zinc finger protein	575					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(5)|large_intestine(8)|lung(11)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	33						GTCCGTCTGCTCGTGGGTGGT	0.647000													13	12					0	0	1	0	0
IGSF9	57549	broad.mit.edu	37	1	159901688	159901688	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:159901688C>T	ENST00000368094.1	-	11	1473	c.1276G>A	c.(1276-1278)Gaa>Aaa	p.E426K	IGSF9_ENST00000493195.1_5'UTR|IGSF9_ENST00000361509.3_Missense_Mutation_p.E410K	NM_001135050.1	NP_001128522.1	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9	426	Ig-like 5.					cell junction|integral to membrane|synapse				central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(17)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			AAATATTCTTCCTTGGGCCGC	0.577000													14	36					0	0	1	0	0
MAST2	23139	broad.mit.edu	37	1	46383157	46383157	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:46383157C>T	ENST00000372008.1	+	2	274	c.107C>T	c.(106-108)gCc>gTc	p.A36V	MAST2_ENST00000372009.2_Intron|MAST2_ENST00000361297.2_Intron			Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase 2	1641					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			breast(1)|lung(3)|ovary(5)|stomach(2)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					AACCCACGAGCCCACAGCAGT	0.532000													18	39					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38997973	38997973	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:38997973C>T	ENST00000359357.3	+	91	13532	c.13278C>T	c.(13276-13278)ttC>ttT	p.F4426F	DNAH8_ENST00000441566.1_Silent_p.F4390F					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AGGTACTCTTCACGCAGTTAC	0.517000											OREG0017409	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	22					0	0	1	0	0
CELF4	56853	broad.mit.edu	37	18	34854406	34854406	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr18:34854406G>A	ENST00000420428.2	-	6	1064	c.669C>T	c.(667-669)tcC>tcT	p.S223S	RP11-797E24.3_ENST00000588766.1_RNA|CELF4_ENST00000601019.1_Silent_p.S222S|CELF4_ENST00000334919.5_Silent_p.S213S|CELF4_ENST00000591282.1_Silent_p.S223S|CELF4_ENST00000361795.5_Silent_p.S222S|CELF4_ENST00000591287.1_Silent_p.S222S|CELF4_ENST00000412753.1_Silent_p.S223S|CELF4_ENST00000603232.1_Silent_p.S223S|CELF4_ENST00000588597.1_Silent_p.S212S	NM_020180.3	NP_064565.1	Q9BZC1	CELF4_HUMAN	CUGBP, Elav-like family member 4	223	RRM 2.|Sufficient for RNA-binding and MSE- dependent splicing activity.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(18)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	44						CCACCAGACTGGACGAGGCTC	0.701000													32	45					0	0	1	0	0
MPZL3	196264	broad.mit.edu	37	11	118106264	118106264	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:118106264G>A	ENST00000278949.4	-	4	547	c.492C>T	c.(490-492)atC>atT	p.I164I	MPZL3_ENST00000527472.1_Silent_p.I152I|MPZL3_ENST00000525386.1_Intron			Q6UWV2	MPZL3_HUMAN	myelin protein zero-like 3	164					cell adhesion	integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(1)|lung(2)|stomach(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.046)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		CAAAGACAAGGATGGAAAGAA	0.532000													24	47					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	124009158	124009158	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:124009158G>A	ENST00000369005.1	+	22	9100	c.8760G>A	c.(8758-8760)ctG>ctA	p.L2920L	TACC2_ENST00000358010.1_Silent_p.L1066L|TACC2_ENST00000360561.3_Silent_p.L968L|TACC2_ENST00000369004.3_Silent_p.L980L|TACC2_ENST00000453444.2_Silent_p.L2847L|TACC2_ENST00000368999.1_Silent_p.L1010L|TACC2_ENST00000513429.1_Silent_p.L1066L|TACC2_ENST00000369000.1_Silent_p.L543L|TACC2_ENST00000260733.3_Silent_p.L998L|TACC2_ENST00000334433.3_Silent_p.L2920L|TACC2_ENST00000369001.1_Silent_p.L547L|TACC2_ENST00000515603.1_Silent_p.L2798L|TACC2_ENST00000515273.1_Silent_p.L2847L	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2920						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TGGACGCCCTGGAAAGGACGC	0.657000													9	11					0	0	1	0	0
CAPZA3	93661	broad.mit.edu	37	12	18891299	18891299	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:18891299G>A	ENST00000317658.3	+	1	255	c.97G>A	c.(97-99)Gat>Aat	p.D33N		NM_033328.2	NP_201585.1	Q96KX2	CAZA3_HUMAN	capping protein (actin filament) muscle Z-line, alpha 3	33					actin cytoskeleton organization|actin filament capping	F-actin capping protein complex	actin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)	19	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)	Hepatocellular(102;0.194)				TGCCTTTGATGATCTCTGTCT	0.458000													20	21					0	0	1	0	0
BRCA1	672	broad.mit.edu	37	17	41243906	41243906	+	Missense_Mutation	SNP	C	C	A	rs80357805		TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:41243906C>A	ENST00000309486.4	-	9	3781	c.2754G>T	c.(2752-2754)gaG>gaT	p.E918D	BRCA1_ENST00000471181.2_Missense_Mutation_p.E1214D|BRCA1_ENST00000354071.3_Missense_Mutation_p.E1214D|BRCA1_ENST00000493795.1_Missense_Mutation_p.E1167D|BRCA1_ENST00000468300.1_Intron|BRCA1_ENST00000351666.3_Intron|BRCA1_ENST00000346315.3_Missense_Mutation_p.E1214D|BRCA1_ENST00000591849.1_Intron|BRCA1_ENST00000591534.1_Intron|BRCA1_ENST00000352993.3_Intron|BRCA1_ENST00000491747.2_Intron|BRCA1_ENST00000586385.1_Intron|BRCA1_ENST00000357654.3_Missense_Mutation_p.E1214D	NM_007297.3	NP_009228.2	P38398	BRCA1_HUMAN	breast cancer 1, early onset	1214					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(30)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(28)|ovary(36)|skin(2)|stomach(4)|urinary_tract(2)	120		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TAGATAAGTTCTCTTCTGAGG	0.453000			"""D, Mis, N, F, S"""		ovarian	"""breast, ovarian"""		Homologous recombination	Hereditary Breast-Ovarian Cancer, BRCA1 type	TCGA Ovarian(2;0.000030)			16	23					4.7546e-09	4.81289e-09	1	1	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72658179	72658179	+	RNA	SNP	T	T	C	rs147293416	by1000genomes	TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:72658179T>C	ENST00000425256.1	-	0	1732					NR_002164.1																						cagagtgatttcggatgaatt	0.507000													3	32					0	0	1	0	0
PDIA5	10954	broad.mit.edu	37	3	122869163	122869163	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:122869163G>A	ENST00000316218.7	+	14	1320	c.1225G>A	c.(1225-1227)Gag>Aag	p.E409K	PDIA5_ENST00000467157.1_3'UTR	NM_006810.3	NP_006801.1	Q14554	PDIA5_HUMAN	protein disulfide isomerase family A, member 5	409	Thioredoxin 3.				cell redox homeostasis|glycerol ether metabolic process|protein folding|response to stress	endoplasmic reticulum lumen	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			breast(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	21				GBM - Glioblastoma multiforme(114;0.0427)		CAACTTCCGGGAGACCCTGAA	0.602000													19	31					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57417739	57417739	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:57417739C>T	ENST00000543257.1	-	6	1058	c.492G>A	c.(490-492)gtG>gtA	p.V164V	C8B_ENST00000535057.1_Silent_p.V154V|C8B_ENST00000371237.4_Silent_p.V216V	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	216	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						TGTAGCTTTCCACATTGTAGG	0.552000													20	39					0	0	1	0	0
GFRAL	389400	broad.mit.edu	37	6	55216216	55216216	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:55216216C>T	ENST00000340465.2	+	5	622	c.536C>T	c.(535-537)cCt>cTt	p.P179L		NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like	179						integral to membrane	receptor activity			NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CAAAATATACCTTTTAACATT	0.438000													40	71					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139180229	139180229	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:139180229G>A	ENST00000395297.1	-	12	1337	c.1167C>T	c.(1165-1167)ccC>ccT	p.P389P		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	389										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CAGGCAGCGGGGGCATGCTAG	0.602000										HNSCC(54;0.14)			26	132					0	0	1	0	0
MMEL1	79258	broad.mit.edu	37	1	2530228	2530228	+	Splice_Site	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:2530228C>T	ENST00000288709.6	-	12	1256	c.1014_splice	c.e12-1	p.G339_splice	MMEL1_ENST00000502556.1_Splice_Site_p.G191_splice|MMEL1_ENST00000378412.3_Splice_Site_p.G348_splice	NM_033467.3	NP_258428.2	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	348					proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity			cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|urinary_tract(1)	27	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		CCAGTTAAATCCCTGCAGATA	0.488000													9	13					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	5841701	5841701	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:5841701C>T	ENST00000327087.8	-	15	1601	c.1530G>A	c.(1528-1530)acG>acA	p.T510T	ANO2_ENST00000546188.1_Silent_p.T511T|ANO2_ENST00000538154.1_5'UTR|ANO2_ENST00000356134.5_Silent_p.T511T			Q9NQ90	ANO2_HUMAN	anoctamin 2	515						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						CGCCACACTCCGTCGTGTTTG	0.463000													6	24					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113520099	113520099	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:113520099G>A	ENST00000284601.3	-	4	1116	c.1048C>T	c.(1048-1050)Cca>Tca	p.P350S		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	350					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						GCTTTATTTGGAAAATTGACT	0.373000													57	48					0	0	1	0	0
GK2	2712	broad.mit.edu	37	4	80328537	80328537	+	Missense_Mutation	SNP	C	C	T	rs150499437		TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:80328537C>T	ENST00000358842.3	-	1	835	c.818G>A	c.(817-819)gGa>gAa	p.G273E		NM_033214.2	NP_149991.2	Q14410	GLPK2_HUMAN	glycerol kinase 2	273					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity	p.G273E(1)		autonomic_ganglia(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	39						TTTGGCTTGTCCCTCCTGGAA	0.458000													25	28					0	0	1	0	0
CSF2RB	1439	broad.mit.edu	37	22	37333851	37333851	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr22:37333851C>T	ENST00000262825.5	+	14	2236	c.2019C>T	c.(2017-2019)tcC>tcT	p.S673S	CSF2RB_ENST00000403662.3_Silent_p.S667S|CSF2RB_ENST00000536485.1_Silent_p.S614S|CSF2RB_ENST00000406230.1_Silent_p.S673S	NM_000395.2	NP_000386.1	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	667					respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(3)|pancreas(1)|skin(5)|upper_aerodigestive_tract(2)	42					Sargramostim(DB00020)	GGAGTCCCTCCCTGGAGTCCG	0.682000													5	4					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136561546	136561546	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:136561546G>A	ENST00000264162.2	-	11	4627	c.4617C>T	c.(4615-4617)ccC>ccT	p.P1539P		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1539	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		CAATGACAAAGGGCTCATTCA	0.512000													13	21					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152080415	152080415	+	Missense_Mutation	SNP	C	C	T	rs71585886		TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:152080415C>T	ENST00000368804.1	-	2	5277	c.5278G>A	c.(5278-5280)Gaa>Aaa	p.E1760K		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1760	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCTGTTCTTCCCTTTCCGGA	0.602000													25	45					0	0	1	0	0
ZFP64	55734	broad.mit.edu	37	20	50769008	50769008	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:50769008C>T	ENST00000216923.4	-	6	2072	c.1723G>A	c.(1723-1725)Gag>Aag	p.E575K	ZFP64_ENST00000477786.1_Intron|ZFP64_ENST00000346617.4_Missense_Mutation_p.E521K|ZFP64_ENST00000371518.2_Intron|ZFP64_ENST00000361387.2_Intron|ZFP64_ENST00000371515.4_Missense_Mutation_p.E573K	NM_018197.2|NM_199426.1	NP_060667.2|NP_955458.1	Q9NPA5	ZF64A_HUMAN	ZFP64 zinc finger protein	575					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(5)|large_intestine(8)|lung(11)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	33						TCCGTCTGCTCGTGGGTGGTC	0.652000													13	13					0	0	1	0	0
BMP8A	353500	broad.mit.edu	37	1	39957963	39957963	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:39957963C>T	ENST00000331593.5	+	1	646	c.300C>T	c.(298-300)ggC>ggT	p.G100G		NM_181809.3	NP_861525.2	Q7Z5Y6	BMP8A_HUMAN	bone morphogenetic protein 8a	100					cartilage development|cell differentiation|growth|ossification	extracellular space	cytokine activity|growth factor activity			kidney(1)|large_intestine(2)|lung(1)|skin(1)	5	Lung NSC(20;2.08e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;9.69e-19)|Epithelial(16;9.34e-17)|all cancers(16;1.73e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGCGCCTGGGCCGCGCCGACC	0.741000													11	2					0	0	1	0	0
SGSM1	129049	broad.mit.edu	37	22	25270478	25270478	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr22:25270478G>A	ENST00000400359.4	+	13	1395	c.1388G>A	c.(1387-1389)gGg>gAg	p.G463E	SGSM1_ENST00000400358.4_Intron	NM_001039948.2|NM_133454.2	NP_001035037.1|NP_597711.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	463						Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						GTGGCCAGAGGGAGTCAGTGG	0.652000													5	19					0	0	1	0	0
IFNA7	3444	broad.mit.edu	37	9	21201924	21201924	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:21201924G>A	ENST00000239347.3	-	1	280	c.241C>T	c.(241-243)Cat>Tat	p.H81Y		NM_021057.2	NP_066401.2	P01567	IFNA7_HUMAN	interferon, alpha 7	81					blood coagulation|cell-cell signaling|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(6)	12				GBM - Glioblastoma multiforme(5;4.75e-197)|Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		ATCATCTCATGGAGGACAGAG	0.478000													27	15					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	73012741	73012741	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:73012741C>T	ENST00000261180.4	+	13	2353	c.2257C>T	c.(2257-2259)Cct>Tct	p.P753S		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	753					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						GGATTTTCTTCCTTGGCATGC	0.363000													17	40					0	0	1	0	0
TFR2	7036	broad.mit.edu	37	7	100238722	100238722	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:100238722C>T	ENST00000462107.1	-	3	450	c.163G>A	c.(163-165)Gag>Aag	p.E55K	TFR2_ENST00000223051.3_Missense_Mutation_p.E55K|TFR2_ENST00000431692.1_Missense_Mutation_p.E55K			Q9UP52	TFR2_HUMAN	transferrin receptor 2	55					cellular iron ion homeostasis|iron ion transport|proteolysis	cytoplasm|integral to plasma membrane	peptidase activity|transferrin receptor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(1)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					CCCCTCAGCTCCATGGGGCAG	0.677000													5	11					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21011501	21011501	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:21011501G>A	ENST00000381545.3	+	5	574	c.355G>A	c.(355-357)Gga>Aga	p.G119R	SLCO1B7_ENST00000554957.1_Missense_Mutation_p.G119R|SLCO1B3_ENST00000545880.1_3'UTR|SLCO1B3_ENST00000261196.2_Missense_Mutation_p.G119R|LST3_ENST00000540229.1_Missense_Mutation_p.G119R|LST3_ENST00000381541.3_Missense_Mutation_p.G119R|SLCO1B3_ENST00000553473.1_Missense_Mutation_p.G119R	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	119					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					TTTCTTCATGGGATAGTAAGT	0.338000													11	30					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86702227	86702227	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:86702227C>T	ENST00000441037.2	+	4	415	c.320C>T	c.(319-321)cCt>cTt	p.P107L	AGBL1_ENST00000421325.2_Missense_Mutation_p.P107L	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	107					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						GTTATTACTCCTTACACCCGA	0.448000													17	52					0	0	1	0	0
KRT18P55	284085	broad.mit.edu	37	17	26603664	26603664	+	RNA	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:26603664C>T	ENST00000577198.1	-	0	1297					NR_028334.1																						GCATCTACCTCCACAGTCAAC	0.507000													9	4					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9048867	9048867	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:9048867G>A	ENST00000397910.4	-	5	32967	c.32764C>T	c.(32764-32766)Cca>Tca	p.P10922S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10924	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTTGGAGTTGGAATAGCAGAA	0.473000													59	76					0	0	1	0	0
PLK3	1263	broad.mit.edu	37	1	45268772	45268772	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:45268772C>T	ENST00000372201.4	+	7	1134	c.895C>T	c.(895-897)Ccc>Tcc	p.P299S	PLK3_ENST00000465443.1_3'UTR	NM_004073.2	NP_004064.2	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	299	Protein kinase.					membrane	ATP binding|protein binding|protein serine/threonine kinase activity			endometrium(4)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(166;0.155)					TCGGGCCTCACCCCGAGACCG	0.607000													18	45					0	0	1	0	0
C4orf17	84103	broad.mit.edu	37	4	100463150	100463150	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:100463150C>T	ENST00000326581.4	+	9	1326	c.964C>T	c.(964-966)Cct>Tct	p.P322S		NM_032149.2	NP_115525.2	Q53FE4	CD017_HUMAN	chromosome 4 open reading frame 17	322										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|prostate(1)|urinary_tract(3)	18				OV - Ovarian serous cystadenocarcinoma(123;2.08e-08)		ACCAAATTCTCCTCCCAGGCC	0.408000													10	16					0	0	1	0	0
STOX2	56977	broad.mit.edu	37	4	184930856	184930856	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:184930856C>T	ENST00000308497.4	+	3	2300	c.865C>T	c.(865-867)Cag>Tag	p.Q289*	STOX2_ENST00000438269.1_Nonsense_Mutation_p.Q289*	NM_020225.1	NP_064610.1	Q9P2F5	STOX2_HUMAN	storkhead box 2	289					embryo development|maternal placenta development					breast(1)|endometrium(7)|lung(6)	14		all_lung(41;1.89e-12)|Lung NSC(41;3.48e-12)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|all_hematologic(60;0.027)|Prostate(90;0.0283)		all cancers(43;2.85e-26)|Epithelial(43;2.27e-22)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-10)|Colorectal(24;8.23e-06)|GBM - Glioblastoma multiforme(59;1.64e-05)|STAD - Stomach adenocarcinoma(60;3.6e-05)|COAD - Colon adenocarcinoma(29;4.37e-05)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.227)		TTTTTCTGCCCAGTTTCCTCC	0.458000													7	2					0	0	1	0	0
TSC22D4	81628	broad.mit.edu	37	7	100075280	100075280	+	Silent	SNP	A	A	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:100075280A>G	ENST00000300181.2	-	2	1136	c.382T>C	c.(382-384)Ttg>Ctg	p.L128L	TSC22D4_ENST00000393991.1_Intron	NM_030935.3	NP_112197.1	Q9Y3Q8	T22D4_HUMAN	TSC22 domain family, member 4	128					negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|kidney(1)|large_intestine(1)|lung(2)|skin(1)|urinary_tract(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCCAGCTCCAACCTGGAATCC	0.692000													6	6					0	0	1	0	0
AIFM3	150209	broad.mit.edu	37	22	21328382	21328382	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr22:21328382C>T	ENST00000399167.2	+	5	626	c.386C>T	c.(385-387)cCc>cTc	p.P129L	AIFM3_ENST00000335375.5_Missense_Mutation_p.P117L|AIFM3_ENST00000405089.1_Missense_Mutation_p.P135L|AIFM3_ENST00000440238.2_Missense_Mutation_p.P129L|AIFM3_ENST00000399163.2_Missense_Mutation_p.P129L|AIFM3_ENST00000333607.6_Missense_Mutation_p.P129L	NM_144704.2	NP_653305.1			apoptosis-inducing factor, mitochondrion-associated, 3											breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	21	all_cancers(11;3.71e-26)|all_epithelial(7;1.59e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0367)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			GTGCGCTGCCCCTGGCACGGC	0.657000													5	6					0	0	1	0	0
SLC9B1	150159	broad.mit.edu	37	4	103822383	103822383	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:103822383G>A	ENST00000296422.7	-	12	1580	c.1439C>T	c.(1438-1440)aCa>aTa	p.T480I	SLC9B1_ENST00000512651.2_5'UTR|SLC9B1_ENST00000394789.3_Intron	NM_139173.3	NP_631912.2	Q4ZJI4	NHDC1_HUMAN	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	480						integral to membrane	solute:hydrogen antiporter activity										ATTTGGAGCTGTGATCAAGAT	0.443000													16	144					0	0	1	0	0
CTSE	1510	broad.mit.edu	37	1	206328788	206328788	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:206328788C>T	ENST00000361052.3	+	7	988	c.870C>T	c.(868-870)tcC>tcT	p.S290S	CTSE_ENST00000358184.2_Silent_p.S285S|CTSE_ENST00000432969.2_Intron|CTSE_ENST00000360218.2_Intron			P14091	CATE_HUMAN	cathepsin E	290					antigen processing and presentation of exogenous peptide antigen via MHC class II|digestion|proteolysis	endosome	aspartic-type endopeptidase activity			endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|skin(3)	16			BRCA - Breast invasive adenocarcinoma(75;0.0754)			CAGGGACTTCCCTCATCACTG	0.612000													13	30					0	0	1	0	0
HRH1	3269	broad.mit.edu	37	3	11300948	11300948	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:11300948C>T	ENST00000397056.1	+	3	416	c.225C>T	c.(223-225)atC>atT	p.I75I	HRH1_ENST00000438284.2_Silent_p.I75I|HRH1_ENST00000431010.2_Silent_p.I75I	NM_000861.3|NM_001098211.1	NP_000852.1|NP_001091681.1	P35367	HRH1_HUMAN	histamine receptor H1	75					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	CGGACTTGATCGTGGGTGCCG	0.572000													37	37					0	0	1	0	0
G6PC2	57818	broad.mit.edu	37	2	169764443	169764443	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:169764443C>T	ENST00000375363.3	+	5	1014	c.922C>T	c.(922-924)Cat>Tat	p.H308Y	SPC25_ENST00000472216.2_Intron|G6PC2_ENST00000461586.1_3'UTR	NM_021176.2	NP_066999.1	Q9NQR9	G6PC2_HUMAN	glucose-6-phosphatase, catalytic, 2	308					gluconeogenesis|glucose homeostasis|glucose transport|regulation of insulin secretion|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(5)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	13						GCAGCTCTACCATTTCCTCCA	0.468000													44	48					0	0	1	0	0
CRLF3	51379	broad.mit.edu	37	17	29119578	29119578	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:29119578C>T	ENST00000324238.6	-	6	963	c.839G>A	c.(838-840)gGt>gAt	p.G280D	CRLF3_ENST00000544695.1_Missense_Mutation_p.G164D|CRLF3_ENST00000577725.1_Intron|CTD-2349P21.9_ENST00000580085.1_lincRNA	NM_015986.3	NP_057070.3	Q8IUI8	CRLF3_HUMAN	cytokine receptor-like factor 3	280					negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|positive regulation of cell cycle arrest|positive regulation of JAK-STAT cascade|positive regulation of transcription from RNA polymerase II promoter	cytoplasm				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	17		all_hematologic(16;0.014)|Acute lymphoblastic leukemia(14;0.0236)|Myeloproliferative disorder(56;0.0255)				CCCCTCAAAACCAGCTGTCCA	0.403000													26	18					0	0	1	0	0
SLC23A1	9963	broad.mit.edu	37	5	138715763	138715763	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:138715763G>A	ENST00000353963.3	-	7	700	c.662C>T	c.(661-663)tCc>tTc	p.S221F	SLC23A1_ENST00000348729.3_Missense_Mutation_p.S217F	NM_152685.3	NP_689898.2	Q9UHI7	S23A1_HUMAN	solute carrier family 23 (ascorbic acid transporter), member 1	217					brain development|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|response to toxin|transepithelial L-ascorbic acid transport|water-soluble vitamin metabolic process	apical plasma membrane|cytoplasm|integral to plasma membrane|intracellular organelle|membrane fraction	dehydroascorbic acid transporter activity|L-ascorbate:sodium symporter activity|nucleobase transmembrane transporter activity|protein binding|sodium-dependent L-ascorbate transmembrane transporter activity			biliary_tract(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(5)|ovary(1)	19			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)		Vitamin C(DB00126)	CAGGAGAATGGAGCTGGGGGC	0.622000													5	4					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100108571	100108571	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:100108571C>T	ENST00000395996.1	+	4	434	c.323C>T	c.(322-324)aCc>aTc	p.T108I	VPS13B_ENST00000355155.1_Missense_Mutation_p.T108I|VPS13B_ENST00000441350.2_Missense_Mutation_p.T108I|VPS13B_ENST00000357162.2_Missense_Mutation_p.T108I|VPS13B_ENST00000358544.2_Missense_Mutation_p.T108I			Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	108					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TCTAATTCTACCAACCGTAGT	0.368000													11	58					0	0	1	0	0
AMBRA1	55626	broad.mit.edu	37	11	46563868	46563868	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:46563868G>A	ENST00000458649.2	-	7	2117	c.1699C>T	c.(1699-1701)Cgc>Tgc	p.R567C	AMBRA1_ENST00000314845.3_Missense_Mutation_p.R477C|AMBRA1_ENST00000298834.3_Missense_Mutation_p.R567C|AMBRA1_ENST00000426438.1_Missense_Mutation_p.R567C|AMBRA1_ENST00000534300.1_Missense_Mutation_p.R567C|AMBRA1_ENST00000533727.1_Missense_Mutation_p.R477C|AMBRA1_ENST00000528950.1_Missense_Mutation_p.R567C			Q9C0C7	AMRA1_HUMAN	autophagy/beclin-1 regulator 1	567					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				NS(1)|breast(3)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	39				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		GCACGACAGCGATTCAGGTGG	0.552000													22	48					0	0	1	0	0
STON2	85439	broad.mit.edu	37	14	81744241	81744241	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:81744241G>A	ENST00000555447.1	-	6	1826	c.1414C>T	c.(1414-1416)Cgt>Tgt	p.R472C	STON2_ENST00000267540.2_Missense_Mutation_p.R472C	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	472	SHD.				endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding	p.R472S(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		TTGAACTCACGGAATGGTTTT	0.488000													56	73					0	0	1	0	0
PLAG1	5324	broad.mit.edu	37	8	57079568	57079568	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:57079568T>C	ENST00000316981.3	-	5	1216	c.737A>G	c.(736-738)gAa>gGa	p.E246G	PLAG1_ENST00000429357.2_Missense_Mutation_p.E246G|PLAG1_ENST00000423799.2_Missense_Mutation_p.E164G	NM_001114634.1|NM_002655.2	NP_001108106.1|NP_002646.2	Q6DJT9	PLAG1_HUMAN	pleiomorphic adenoma gene 1	246	Activates transcription; Inhibition of nuclear import due to lack of NLS and KPNA2 interaction.|Repression domain; contains 3 sumoylation motifs and massively decrease transcription activity.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding		CTNNB1/PLAG1(60)|LIFR_ENST00000263409/PLAG1(10)|HAS2/PLAG1(10)|FGFR1_ENST00000447712/PLAG1(28)|COL1A2/PLAG1(3)|CHCHD7/PLAG1(12)|TCEA1_ENST00000521604/PLAG1(3)	breast(3)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(7)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00179)|all cancers(17;0.0125)			ATCCACTGGTTCTGTTTTGAC	0.448000			T	"""TCEA1, LIFR, CTNNB1, CHCHD7"""	salivary adenoma								29	90					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124297720	124297720	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:124297720C>T	ENST00000409039.3	+	19	2825	c.2800C>T	c.(2800-2802)Cgt>Tgt	p.R934C		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	934	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GCATTTTGTTCGTTGGATGAA	0.378000													8	20					0	0	1	0	0
OR5D13	390142	broad.mit.edu	37	11	55541054	55541054	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:55541054G>A	ENST00000361760.1	+	1	141	c.141G>A	c.(139-141)atG>atA	p.M47I		NM_001001967.1	NP_001001967.1	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D, member 13	47					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(20)|ovary(1)|pancreas(2)|skin(2)|stomach(1)|urinary_tract(1)	40		all_epithelial(135;0.196)				ACTTGGGCATGATAATAATCA	0.393000													34	48					0	0	1	0	0
TCTN2	79867	broad.mit.edu	37	12	124163787	124163787	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:124163787C>T	ENST00000303372.5	+	5	643	c.515C>T	c.(514-516)cCt>cTt	p.P172L	TCTN2_ENST00000426174.2_Missense_Mutation_p.P171L	NM_001143850.2|NM_024809.4	NP_001137322.1|NP_079085.2	Q96GX1	TECT2_HUMAN	tectonic family member 2	172	Cys-rich.				cilium assembly|smoothened signaling pathway	integral to membrane				breast(2)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		GGCCCTTGTCCTTGTAATTTA	0.448000													26	41					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73848172	73848172	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:73848172C>T	ENST00000523207.1	+	3	1170	c.582C>T	c.(580-582)atC>atT	p.I194I		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	194					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			TTTTCCAGATCCTGGCCATCG	0.463000													45	118					0	0	1	0	0
SLC22A13	9390	broad.mit.edu	37	3	38307716	38307716	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:38307716C>T	ENST00000311856.4	+	1	414	c.365C>T	c.(364-366)tCc>tTc	p.S122F	SLC22A13_ENST00000450935.2_Missense_Mutation_p.S81F	NM_004256.3	NP_004247.2	Q9Y226	S22AD_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 13	122						integral to plasma membrane	organic cation transmembrane transporter activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|urinary_tract(1)	20				KIRC - Kidney renal clear cell carcinoma(284;0.0533)|Kidney(284;0.067)		AGGCTCCCATCCCTGAAGAAT	0.577000													12	21					0	0	1	0	0
CHRDL2	25884	broad.mit.edu	37	11	74414511	74414511	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:74414511C>T	ENST00000376332.3	-	8	1281	c.785G>A	c.(784-786)gGg>gAg	p.G262E	CHRDL2_ENST00000263671.5_Missense_Mutation_p.G262E|CHRDL2_ENST00000534159.1_5'UTR	NM_001278473.1	NP_001265402.1	Q6WN34	CRDL2_HUMAN	chordin-like 2	262	VWFC 3.				cartilage development|cell differentiation|ossification	extracellular region|mitochondrion				endometrium(1)|kidney(1)|large_intestine(6)|lung(4)|prostate(1)|skin(2)	15	Hepatocellular(1;0.098)					CCACACCTCCCCGTGGGAGTA	0.652000													6	10					0	0	1	0	0
MIDN	90007	broad.mit.edu	37	19	1255597	1255597	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:1255597C>T	ENST00000300952.2	+	7	1548	c.1033C>T	c.(1033-1035)Ctg>Ttg	p.L345L	MIDN_ENST00000591446.2_Silent_p.L345L	NM_177401.4	NP_796375.3	Q504T8	MIDN_HUMAN	midnolin	345						nucleolus				NS(1)|endometrium(3)|kidney(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCCCCCGACCTGGCCCCCAG	0.721000													19	14					0	0	1	0	0
CLCA1	1179	broad.mit.edu	37	1	86959080	86959080	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:86959080G>A	ENST00000234701.3	+	11	1829	c.1478G>A	c.(1477-1479)gGa>gAa	p.G493E	CLCA1_ENST00000394711.1_Missense_Mutation_p.G493E			A8K7I4	CLCA1_HUMAN	chloride channel accessory 1	493					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		GAGAGTAAGGGATTAACCCTC	0.493000													18	8					0	0	1	0	0
SLC2A9	56606	broad.mit.edu	37	4	9943652	9943652	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:9943652G>A	ENST00000506583.1	-	8	829	c.612C>T	c.(610-612)taC>taT	p.Y204Y	SLC2A9_ENST00000309065.3_Silent_p.Y204Y|SLC2A9_ENST00000264784.3_Silent_p.Y233Y			Q9NRM0	GTR9_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 9	233					glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(1)	35						CTCCAAACAGGTATGGCCAGG	0.582000													6	14					0	0	1	0	0
LAMC2	3918	broad.mit.edu	37	1	183205733	183205733	+	Silent	SNP	C	C	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:183205733C>G	ENST00000264144.4	+	17	2660	c.2595C>G	c.(2593-2595)tcC>tcG	p.S865S	LAMC2_ENST00000493293.1_Silent_p.S865S	NM_005562.2	NP_005553.2	Q13753	LAMC2_HUMAN	laminin, gamma 2	865	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			breast(2)|endometrium(6)|kidney(8)|large_intestine(11)|lung(18)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55						GTGATCAGTCCTTTCAGGTGA	0.488000													16	33					0	0	1	0	0
SYT12	91683	broad.mit.edu	37	11	66807423	66807423	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:66807423C>T	ENST00000393946.2	+	7	1532	c.370C>T	c.(370-372)Ccc>Tcc	p.P124S	SYT12_ENST00000525457.1_Missense_Mutation_p.P124S|SYT12_ENST00000527043.1_Missense_Mutation_p.P124S|SYT12_ENST00000526281.1_3'UTR			Q8IV01	SYT12_HUMAN	synaptotagmin XII	124						cell junction|integral to membrane|synaptic vesicle membrane				NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|urinary_tract(1)	20						GGACCTGGCCCCCTATGGGAC	0.617000													21	46					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3238619	3238619	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:3238619C>T	ENST00000217939.6	-	5	5261	c.5107G>A	c.(5107-5109)Gga>Aga	p.G1703R		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1703						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TTGTTATTTCCAAACACTTTG	0.428000													30	44					0	0	1	0	0
CTR9	9646	broad.mit.edu	37	11	10789453	10789453	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:10789453C>T	ENST00000361367.2	+	14	2213	c.1787C>T	c.(1786-1788)tCc>tTc	p.S596F		NM_014633.3	NP_055448.1	Q6PD62	CTR9_HUMAN	CTR9, Paf1/RNA polymerase II complex component	596					histone H2B ubiquitination|histone monoubiquitination	Cdc73/Paf1 complex|nuclear speck				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|pancreas(1)|stomach(1)	40				all cancers(16;1.64e-07)|Epithelial(150;2.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		AAACAGCCATCCACACAGAGT	0.443000													71	103					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10363572	10363572	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:10363572G>A	ENST00000255381.2	-	13	1324	c.1214C>T	c.(1213-1215)cCc>cTc	p.P405L	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	405	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						CTTGACTCTGGGATAGCAGAG	0.453000													16	28					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34015840	34015840	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:34015840C>T	ENST00000373381.4	-	56	9030	c.8854G>A	c.(8854-8856)Gga>Aga	p.G2952R		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2928	Sushi 22.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GTGCTGTTTCCCACCAGAGTA	0.597000													24	42					0	0	1	0	0
MAGEA10	4109	broad.mit.edu	37	X	151303797	151303797	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:151303797G>A	ENST00000370323.4	-	4	612	c.296C>T	c.(295-297)tCc>tTc	p.S99F	MAGEA10_ENST00000244096.3_Missense_Mutation_p.S99F|RP11-1007I13.4_ENST00000509345.2_RNA	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	99										endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					TAATGGAAGGGAAGCAACGAC	0.537000													73	25					0	0	1	0	0
OAS2	4939	broad.mit.edu	37	12	113424859	113424859	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:113424859G>A	ENST00000392583.2	+	2	401	c.194G>A	c.(193-195)cGg>cAg	p.R65Q	RP1-71H24.1_ENST00000552784.1_RNA|OAS2_ENST00000449768.2_Missense_Mutation_p.R65Q|OAS2_ENST00000342315.4_Missense_Mutation_p.R65Q	NM_002535.2	NP_002526.2	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2, 69/71kDa	65	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			NS(1)|breast(2)|endometrium(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						TCCTATGGACGGAAAACAGTC	0.473000													26	48					0	0	1	0	0
SHISA2	387914	broad.mit.edu	37	13	26621094	26621094	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr13:26621094G>A	ENST00000319420.3	-	2	500	c.445C>T	c.(445-447)Ccc>Tcc	p.P149S		NM_001007538.1	NP_001007539.1	Q6UWI4	SHSA2_HUMAN	shisa family member 2	149					multicellular organismal development	endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(2)|skin(1)	17						CTCTGCTGGGGATCCTGCTTA	0.627000													55	10					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3238685	3238685	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:3238685G>A	ENST00000217939.6	-	5	5195	c.5041C>T	c.(5041-5043)Ccc>Tcc	p.P1681S		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1681						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GGAATGCTGGGTTTGGACATG	0.413000													45	82					0	0	1	0	0
GMPPA	29926	broad.mit.edu	37	2	220366636	220366636	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:220366636C>T	ENST00000358215.3	+	5	675	c.306C>T	c.(304-306)atC>atT	p.I102I	GMPPA_ENST00000313597.5_Silent_p.I102I|GMPPA_ENST00000373908.1_Silent_p.I102I|GMPPA_ENST00000341142.3_Silent_p.I102I|GMPPA_ENST00000373917.3_Silent_p.I102I|AC053503.11_ENST00000429882.1_RNA	NM_205847.2	NP_995319.1	Q96IJ6	GMPPA_HUMAN	GDP-mannose pyrophosphorylase A	102					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(1)	20		Renal(207;0.0183)		Epithelial(149;3.82e-10)|all cancers(144;6.25e-08)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00807)|READ - Rectum adenocarcinoma(5;0.148)		GAGACCAGATCCTGGCTGGGA	0.597000													34	56					0	0	1	0	0
GPER1	2852	broad.mit.edu	37	7	1132424	1132424	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:1132424G>A	ENST00000397092.1	+	3	1944	c.1060G>A	c.(1060-1062)Gct>Act	p.A354T	C7orf50_ENST00000357429.6_Intron|GPER_ENST00000397088.3_Missense_Mutation_p.A354T|GPER_ENST00000297469.3_Missense_Mutation_p.A354T|C7orf50_ENST00000488073.1_Intron|C7orf50_ENST00000397098.3_Intron|C7orf50_ENST00000397100.2_Intron|GPER_ENST00000401670.1_Missense_Mutation_p.A354T	NM_001039966.1	NP_001035055.1	Q99527	GPER_HUMAN		354						endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)	13		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;2.32e-16)		CTTCTGTCACGCTGCCCTGAA	0.587000													3	18					0	0	1	0	0
BMP10	27302	broad.mit.edu	37	2	69093276	69093276	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:69093276G>A	ENST00000295379.1	-	2	920	c.762C>T	c.(760-762)atC>atT	p.I254I		NM_014482.1	NP_055297.1	O95393	BMP10_HUMAN	bone morphogenetic protein 10	254					activin receptor signaling pathway|adult heart development|atrial cardiac muscle tissue morphogenesis|BMP signaling pathway|cardiac muscle cell proliferation|heart trabecula formation|negative regulation of cardiac muscle hypertrophy|negative regulation of cell growth|negative regulation of endothelial cell migration|Notch signaling pathway|pathway-restricted SMAD protein phosphorylation|positive regulation of cardiac muscle cell proliferation|positive regulation of cardiac muscle hypertrophy|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent|sarcomere organization|ventricular cardiac muscle cell development|ventricular cardiac muscle tissue morphogenesis	cell surface|extracellular space|Z disc	cytokine activity|growth factor activity|receptor serine/threonine kinase binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(15)|ovary(2)	27						CAGAAAACACGATGAGCAAAG	0.483000													11	11					0	0	1	0	0
LPPR4	9890	broad.mit.edu	37	1	99772544	99772544	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:99772544C>T	ENST00000370185.3	+	7	2767	c.2270C>T	c.(2269-2271)cCc>cTc	p.P757L	LPPR4_ENST00000370184.1_Missense_Mutation_p.P599L|LPPR4_ENST00000457765.1_Missense_Mutation_p.P699L	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		757							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		GGAACCTCCCCCACACGGGCT	0.463000													25	47					0	0	1	0	0
SLC17A6	57084	broad.mit.edu	37	11	22398996	22398996	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:22398996C>T	ENST00000263160.3	+	12	1896	c.1459C>T	c.(1459-1461)Cac>Tac	p.H487Y		NM_020346.2	NP_065079.1	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 6	487					sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)	50						TGCCCTAGTCCACTATGGTGG	0.453000													12	13					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	96030984	96030984	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:96030984C>T	ENST00000297954.4	+	18	3989	c.3989C>T	c.(3988-3990)tCg>tTg	p.S1330L	WNK2_ENST00000395475.2_3'UTR|WNK2_ENST00000395477.2_Missense_Mutation_p.S1330L|WNK2_ENST00000427277.2_Missense_Mutation_p.S942L|WNK2_ENST00000356055.3_5'UTR|WNK2_ENST00000349097.3_Missense_Mutation_p.S942L			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1330					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity	p.S1316L(1)|p.S1330L(1)		breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						CCTGAATCTTCGCCCCCACTT	0.617000													13	4					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57334182	57334182	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:57334182C>T	ENST00000326441.9	-	6	867	c.504G>A	c.(502-504)agG>agA	p.R168R	ZIM2_ENST00000593711.1_Silent_p.R43R|PEG3_ENST00000593695.1_Silent_p.R42R|PEG3_ENST00000423103.2_Silent_p.R168R|ZIM2_ENST00000391708.3_Silent_p.R43R|PEG3_ENST00000598410.1_Silent_p.R43R|ZIM2_ENST00000593931.1_Silent_p.R43R|ZIM2_ENST00000601070.1_Silent_p.R43R|ZIM2_ENST00000221722.5_Silent_p.R43R|ZIM2_ENST00000599935.1_Silent_p.R43R	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	168					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TGCTTCTGCCCCTCCGGTCCC	0.532000													10	10					0	0	1	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24256516	24256516	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:24256516C>T	ENST00000538205.1	+	10	1202	c.655C>T	c.(655-657)Ctg>Ttg	p.L219L	RP11-624C23.1_ENST00000523578.1_RNA|ADAMDEC1_ENST00000256412.4_Silent_p.L298L|RP11-624C23.1_ENST00000519689.1_RNA|ADAMDEC1_ENST00000522298.1_Silent_p.L219L	NM_001145271.1	NP_001138743.1	O15204	ADEC1_HUMAN	ADAM-like, decysin 1	298	Peptidase M12B.				integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|large_intestine(4)|skin(2)|stomach(1)	9		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		CAGTTCTAACCTGGGGAAAAA	0.512000													7	16					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42694391	42694391	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:42694391A>G	ENST00000358131.5	+	6	1154	c.946A>G	c.(946-948)Aac>Gac	p.N316D	TOX2_ENST00000423191.1_Missense_Mutation_p.N292D|TOX2_ENST00000341197.3_Missense_Mutation_p.N334D|TOX2_ENST00000372999.1_Missense_Mutation_p.N292D|TOX2_ENST00000435864.2_Missense_Mutation_p.N212D	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	316					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CACTCAGGCAAACCCACCAGC	0.587000													53	104					0	0	1	0	0
CASS4	57091	broad.mit.edu	37	20	55012289	55012289	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:55012289G>A	ENST00000371336.3	+	2	307	c.106G>A	c.(106-108)Gac>Aac	p.D36N	CASS4_ENST00000434344.1_Missense_Mutation_p.D36N|CASS4_ENST00000360314.3_Missense_Mutation_p.D36N	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	36	SH3.				cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						CAGCAGAGGGGACATCCTGAC	0.592000													20	41					0	0	1	0	0
COL6A1	1291	broad.mit.edu	37	21	47414119	47414119	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr21:47414119C>T	ENST00000361866.3	+	20	1488	c.1374C>T	c.(1372-1374)ggC>ggT	p.G458G		NM_001848.2	NP_001839.2	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1	458	Triple-helical region.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	GAAGAGAAGGCCCCGTTGGTG	0.637000													3	11					0	0	1	0	0
PAH	5053	broad.mit.edu	37	12	103249033	103249033	+	Missense_Mutation	SNP	G	G	A	rs62895363		TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:103249033G>A	ENST00000553106.1	-	6	1059	c.587C>T	c.(586-588)tCc>tTc	p.S196F	PAH_ENST00000307000.2_Missense_Mutation_p.S191F	NM_000277.1	NP_000268.1	P00439	PH4H_HUMAN	phenylalanine hydroxylase	196					catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			endometrium(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(5)|skin(2)|urinary_tract(1)	27					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	TTTATACAAGGACTTCAGAGT	0.438000													11	8					0	0	1	0	0
TUBA3C	7278	broad.mit.edu	37	13	19751599	19751599	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr13:19751599G>A	ENST00000400113.3	-	4	628	c.524C>T	c.(523-525)cCc>cTc	p.P175L		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	175					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		GGAGACCTGGGGGGCTGGGTA	0.582000													305	23					0	0	1	0	0
PAPLN	89932	broad.mit.edu	37	14	73726011	73726011	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:73726011C>T	ENST00000427855.1	+	16	1845	c.1743C>T	c.(1741-1743)caC>caT	p.H581H	PAPLN_ENST00000554301.1_Silent_p.H581H|PAPLN_ENST00000555445.1_Silent_p.H581H|PAPLN_ENST00000381166.3_Silent_p.H581H|PAPLN_ENST00000340738.5_Silent_p.H554H			O95428	PPN_HUMAN	papilin, proteoglycan-like sulfated glycoprotein	581						proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(3)	42				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		CCCAGGAACACCCCTCAGCCA	0.657000													18	47					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23928772	23928772	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr13:23928772T>C	ENST00000382298.3	-	8	2567	c.1979A>G	c.(1978-1980)tAc>tGc	p.Y660C	SACS_ENST00000382292.3_Missense_Mutation_p.Y660C|SACS_ENST00000402364.1_5'UTR|SACS_ENST00000476776.1_5'UTR	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	660					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CAGCTCACTGTAGGCTTGGTC	0.507000													73	10					0	0	1	0	0
PRRC2B	84726	broad.mit.edu	37	9	134340309	134340309	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:134340309C>T	ENST00000357304.4	+	11	1619	c.1564C>T	c.(1564-1566)Ctg>Ttg	p.L522L	PRRC2B_ENST00000405995.1_Silent_p.L522L|PRRC2B_ENST00000372249.1_5'UTR|PRRC2B_ENST00000458550.1_Silent_p.L522L	NM_013318.3	NP_037450.2	Q5JSZ5	PRC2B_HUMAN	proline-rich coiled-coil 2B	522							protein binding			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(20)|ovary(2)	44						GGAGGAGAGGCTGGCCGCCTG	0.632000													12	4					0	0	1	0	0
PAPD7	11044	broad.mit.edu	37	5	6748684	6748684	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:6748684C>T	ENST00000230859.6	+	8	946	c.817C>T	c.(817-819)Cca>Tca	p.P273S		NM_001171805.1|NM_001171806.1|NM_006999.4	NP_001165276.1|NP_001165277.1|NP_008930.1	Q5XG87	PAPD7_HUMAN	PAP associated domain containing 7	273					cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			cervix(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						CAGGTCCTATCCAAACAGAGA	0.552000													34	93					0	0	1	0	0
EED	8726	broad.mit.edu	37	11	85975253	85975253	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:85975253T>C	ENST00000263360.6	+	7	1360	c.674T>C	c.(673-675)cTg>cCg	p.L225P	EED_ENST00000351625.6_Missense_Mutation_p.L225P|EED_ENST00000327320.4_Missense_Mutation_p.L225P|EED_ENST00000528180.1_Missense_Mutation_p.L225P	NM_003797.3	NP_003788.2	O75530	EED_HUMAN	embryonic ectoderm development	225	Interaction with EZH2 (By similarity).|Required for interaction with the matrix protein MA of HIV-1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	21		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				ACGGACACTCTGGTGGCAATA	0.388000													30	41					0	0	1	0	0
ASZ1	136991	broad.mit.edu	37	7	117007411	117007411	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:117007411G>A	ENST00000284629.2	-	12	1332	c.1270C>T	c.(1270-1272)Caa>Taa	p.Q424*		NM_130768.2	NP_570124.1	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper domain containing 1	424					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(3)|skin(1)	24	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			TATACCTTTTGAATTAGGTCT	0.343000													8	7					0	0	1	0	0
ZNF25	219749	broad.mit.edu	37	10	38241235	38241235	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:38241235G>A	ENST00000302609.7	-	6	1403	c.1191C>T	c.(1189-1191)ccC>ccT	p.P397P	ZNF25_ENST00000374633.1_5'UTR	NM_145011.2	NP_659448.1	P17030	ZNF25_HUMAN	zinc finger protein 25	397					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_neural(218;0.0218)|Breast(68;0.0389)|Ovarian(717;0.0443)|Renal(717;0.157)				TGCATGCATAGGGCTTCTCTC	0.443000													16	36					0	0	1	0	0
OR2T33	391195	broad.mit.edu	37	1	248436155	248436155	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:248436155C>T	ENST00000318021.2	-	1	983	c.962G>A	c.(961-963)tGa>tAa	p.*321*		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	0					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GACATTAGATCATCTTGACCT	0.388000													34	64					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168175342	168175342	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:168175342G>A	ENST00000519560.1	-	20	2654	c.2235C>T	c.(2233-2235)gcC>gcT	p.A745A	SLIT3_ENST00000404867.3_Silent_p.A745A|SLIT3_ENST00000332966.8_Silent_p.A745A	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	745	LRRNT 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTCTGGGGAGGGCGCGGAGCC	0.622000													31	47					0	0	1	0	0
BCAS1	8537	broad.mit.edu	37	20	52569975	52569975	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:52569975C>T	ENST00000395961.3	-	11	1842	c.1676G>A	c.(1675-1677)gGc>gAc	p.G559D	BCAS1_ENST00000434986.2_Missense_Mutation_p.G225D|BCAS1_ENST00000371435.2_Missense_Mutation_p.G481D|BCAS1_ENST00000371440.3_Missense_Mutation_p.G568D	NM_003657.2	NP_003648.2	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	559						cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(23)|ovary(2)|skin(2)|stomach(1)|urinary_tract(1)	37	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			ACCTACCAGGCCTTTAAAGAA	0.517000													11	24					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57334181	57334181	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:57334181C>T	ENST00000326441.9	-	6	868	c.505G>A	c.(505-507)Ggc>Agc	p.G169S	ZIM2_ENST00000593711.1_Missense_Mutation_p.G44S|PEG3_ENST00000593695.1_Missense_Mutation_p.G43S|PEG3_ENST00000423103.2_Missense_Mutation_p.G169S|ZIM2_ENST00000391708.3_Missense_Mutation_p.G44S|PEG3_ENST00000598410.1_Missense_Mutation_p.G44S|ZIM2_ENST00000593931.1_Missense_Mutation_p.G44S|ZIM2_ENST00000601070.1_Missense_Mutation_p.G44S|ZIM2_ENST00000221722.5_Missense_Mutation_p.G44S|ZIM2_ENST00000599935.1_Missense_Mutation_p.G44S	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	169					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CTGCTTCTGCCCCTCCGGTCC	0.532000													10	9					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141607853	141607853	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:141607853C>T	ENST00000389484.3	-	29	5728	c.4757G>A	c.(4756-4758)gGa>gAa	p.G1586E		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1586					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AATATCCACTCCTCTGATTTC	0.348000										TSP Lung(27;0.18)			8	22					0	0	1	0	0
GAB1	2549	broad.mit.edu	37	4	144361025	144361025	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:144361025C>T	ENST00000262995.4	+	5	1693	c.1266C>T	c.(1264-1266)ggC>ggT	p.G422G	GAB1_ENST00000505913.1_Silent_p.G319G|GAB1_ENST00000262994.4_Silent_p.G422G	NM_207123.2	NP_997006.1	Q13480	GAB1_HUMAN	GRB2-associated binding protein 1	422					cell proliferation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			breast(3)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	30	all_hematologic(180;0.158)					CACTTGAAGGCTTCCATAACC	0.333000													8	17					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176638665	176638665	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:176638665G>A	ENST00000439151.2	+	5	3310	c.3265G>A	c.(3265-3267)Gat>Aat	p.D1089N	NSD1_ENST00000347982.4_Missense_Mutation_p.D820N|NSD1_ENST00000361032.4_Missense_Mutation_p.D986N|NSD1_ENST00000354179.4_Missense_Mutation_p.D820N	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1089					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TAGTAAAGAGGATCCCCTTCA	0.453000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			24	35					0	0	1	0	0
ASPM	259266	broad.mit.edu	37	1	197073649	197073649	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:197073649G>A	ENST00000367409.4	-	18	4988	c.4732C>T	c.(4732-4734)Cga>Tga	p.R1578*	ASPM_ENST00000294732.7_Intron|ASPM_ENST00000367408.1_Intron	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	1578					mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						TTTAAAAATCGAACTCTGTCT	0.338000													20	28					0	0	1	0	0
PSD2	84249	broad.mit.edu	37	5	139193941	139193941	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:139193941G>A	ENST00000274710.3	+	4	1213	c.1008G>A	c.(1006-1008)ctG>ctA	p.L336L		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	336	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCGGCAGCTGGGCAAGAAGT	0.637000													6	22					0	0	1	0	0
TXNL4A	10907	broad.mit.edu	37	18	77733800	77733800	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr18:77733800G>A	ENST00000269601.5	-	3	514	c.314C>T	c.(313-315)gCc>gTc	p.A105V	TXNL4A_ENST00000588162.1_3'UTR|TXNL4A_ENST00000592957.1_Missense_Mutation_p.A34V|TXNL4A_ENST00000592837.1_Missense_Mutation_p.A34V|TXNL4A_ENST00000585474.1_Missense_Mutation_p.A34V	NM_006701.2	NP_006692.1	P83876	TXN4A_HUMAN	thioredoxin-like 4A	105					cell division|mitosis|spliceosome assembly	nucleoplasm|spliceosomal complex	protein binding			breast(1)|large_intestine(1)|lung(3)	5		all_cancers(4;1.15e-12)|all_epithelial(4;8.61e-09)|all_lung(4;0.00366)|Lung NSC(4;0.00683)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0646)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;7.36e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0249)		GTCCTCCATGGCCCAGTTAAT	0.547000													33	55					0	0	1	0	0
NPHP3	27031	broad.mit.edu	37	3	132441115	132441115	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:132441115C>T	ENST00000326682.8	-	1	161	c.85G>A	c.(85-87)Gag>Aag	p.E29K	NPHP3_ENST00000343113.4_Missense_Mutation_p.E29K|NPHP3_ENST00000337331.5_Missense_Mutation_p.E29K|NPHP3-AS1_ENST00000489343.1_RNA|NPHP3_ENST00000383282.2_Missense_Mutation_p.E29K			Q7Z494	NPHP3_HUMAN	nephronophthisis 3 (adolescent)	29					maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(15)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						ACCGGGATCTCGCAGGCCTCG	0.771000													6	13					0	0	1	0	0
PLA2G4D	283748	broad.mit.edu	37	15	42374026	42374026	+	Missense_Mutation	SNP	C	C	T	rs150830051		TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:42374026C>T	ENST00000290472.3	-	10	884	c.790G>A	c.(790-792)Gga>Aga	p.G264R		NM_178034.3	NP_828848.3	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD (cytosolic)	264					phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		AGCCTCACTCCTGGGGCCTGA	0.577000													81	46					0	0	1	0	0
C9	735	broad.mit.edu	37	5	39342232	39342232	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:39342232C>T	ENST00000263408.4	-	2	239	c.144G>A	c.(142-144)tgG>tgA	p.W48*	C9_ENST00000509186.1_5'UTR	NM_001737.3	NP_001728.1	P02748	CO9_HUMAN	complement component 9	48	TSP type-1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex				central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			ACCATTCACTCCAGGGGCTCA	0.463000													13	25					0	0	1	0	0
WFDC5	149708	broad.mit.edu	37	20	43743701	43743701	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:43743701G>A	ENST00000307971.4	-	1	102	c.24C>T	c.(22-24)ctC>ctT	p.L8L	WFDC5_ENST00000372789.4_Silent_p.L8L			Q8TCV5	WFDC5_HUMAN	WAP four-disulfide core domain 5	8						extracellular region	serine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				GGGCCCCCAGGAGGAGAAGGC	0.617000													9	20					0	0	1	0	0
UQCRFS1	7386	broad.mit.edu	37	19	29699024	29699024	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:29699024G>A	ENST00000304863.4	-	2	678	c.256C>T	c.(256-258)Cct>Tct	p.P86S		NM_006003.2	NP_005994.2	P47985	UCRI_HUMAN	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	86					respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex III	2 iron, 2 sulfur cluster binding|metal ion binding|ubiquinol-cytochrome-c reductase activity			endometrium(4)|kidney(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Breast(6;0.0545)|Esophageal squamous(110;0.239)		Lung(7;0.092)			GAGAAGTCAGGCACCTTGATG	0.433000													13	38					0	0	1	0	0
PPP1R10	5514	broad.mit.edu	37	6	30571389	30571389	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:30571389C>T	ENST00000376511.2	-	16	2179	c.1627G>A	c.(1627-1629)Ggt>Agt	p.G543S		NM_002714.3	NP_002705.2	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	543	Gly-rich.|Interaction with WDR82 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(1)	25						GGTGAGCCACCTGACCCCCCA	0.532000													39	70					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41577266	41577266	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:41577266G>A	ENST00000396942.1	-	10	1103	c.1020C>T	c.(1018-1020)acC>acT	p.T340T	ANK1_ENST00000379758.2_Silent_p.T340T|ANK1_ENST00000347528.4_Silent_p.T340T|ANK1_ENST00000352337.4_Silent_p.T340T|ANK1_ENST00000265709.8_Silent_p.T373T|ANK1_ENST00000289734.7_Silent_p.T340T|ANK1_ENST00000396945.1_Silent_p.T340T			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	340	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CGTGGAGTGGGGTCAGGTGGT	0.607000													54	73					0	0	1	0	0
ASPM	259266	broad.mit.edu	37	1	197071568	197071568	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:197071568C>T	ENST00000367409.4	-	18	7069	c.6813G>A	c.(6811-6813)agG>agA	p.R2271R	ASPM_ENST00000294732.7_Intron|ASPM_ENST00000367408.1_Intron	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	2271	IQ 21.				mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						TTCTAAATCTCCTCTGAATGA	0.358000													26	51					0	0	1	0	0
SPRR1A	6698	broad.mit.edu	37	1	152957798	152957798	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:152957798A>G	ENST00000307122.2	+	2	156	c.92A>G	c.(91-93)gAa>gGa	p.E31G	SPRR1A_ENST00000368762.1_Missense_Mutation_p.E31G	NM_001199828.1|NM_005987.3	NP_001186757.1|NP_005978.2	P35321	SPR1A_HUMAN	small proline-rich protein 1A	31	6 X 8 AA approximate tandem repeats.				keratinization|peptide cross-linking	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			breast(2)|endometrium(1)|large_intestine(1)|liver(2)|lung(1)	7	Lung NSC(65;1.46e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCACCCCAGGAACCATGCATC	0.612000													44	60					0	0	1	0	0
KCNA6	3742	broad.mit.edu	37	12	4920518	4920518	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:4920518C>T	ENST00000433855.1	+	1	2177	c.1311C>T	c.(1309-1311)atC>atT	p.I437I	KCNA6_ENST00000280684.3_Silent_p.I437I	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	437						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						GGGGAAAGATCGTGGGCTCGC	0.592000										HNSCC(72;0.22)			22	34					0	0	1	0	0
P2RX5-TAX1BP3	100533970	broad.mit.edu	37	17	3592832	3592832	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:3592832G>A	ENST00000550383.1	-	7	895	c.707C>T	c.(706-708)tCc>tTc	p.S236F	P2RX5_ENST00000345901.3_Missense_Mutation_p.S212F|P2RX5_ENST00000435558.1_Missense_Mutation_p.S236F|P2RX5_ENST00000225328.5_Missense_Mutation_p.S236F|P2RX5_ENST00000547178.1_Missense_Mutation_p.S235F|P2RX5_ENST00000552050.1_Missense_Mutation_p.S176F|P2RX5_ENST00000552276.1_Missense_Mutation_p.S235F|P2RX5_ENST00000550772.1_Intron|P2RX5_ENST00000551178.1_Missense_Mutation_p.S211F																							GCGGATCACGGAGCCCAGTCG	0.622000													33	42					0	0	1	0	0
SP4	6671	broad.mit.edu	37	7	21521639	21521639	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:21521639C>T	ENST00000222584.3	+	5	2223	c.2005C>T	c.(2005-2007)Cgc>Tgc	p.R669C		NM_003112.3	NP_003103.2	Q02446	SP4_HUMAN	Sp4 transcription factor	669					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(11)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	35						AGCACATCTTCGCTGGCATAC	0.408000													22	27					0	0	1	0	0
ANKRD50	57182	broad.mit.edu	37	4	125592806	125592806	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:125592806A>C	ENST00000504087.1	-	4	2663	c.1626T>G	c.(1624-1626)gaT>gaG	p.D542E	ANKRD50_ENST00000515641.1_Missense_Mutation_p.D363E	NM_020337.2	NP_065070.1	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	542										NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(14)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	55						TCCCATTTGAATCACACTGAT	0.398000													34	40					0	0	1	0	0
MIR520H	574493	broad.mit.edu	37	19	54245767	54245767	+	RNA	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:54245767C>T	ENST00000385126.1	+	0	2					NR_030215.1																						GCAAGAAGATCCCATGCTGTG	0.403000													42	51					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27202972	27202972	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:27202972G>A	ENST00000380036.4	+	13	2506	c.2064G>A	c.(2062-2064)aaG>aaA	p.K688K	TEK_ENST00000519097.1_Silent_p.K541K|TEK_ENST00000406359.4_Silent_p.K645K	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	688	Fibronectin type-III 3.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		TTGATGTGAAGATAAAGAATG	0.423000													40	24					0	0	1	0	0
SLC35C2	51006	broad.mit.edu	37	20	44986361	44986361	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:44986361G>C	ENST00000372227.1	-	3	712	c.172C>G	c.(172-174)Ctc>Gtc	p.L58V	SLC35C2_ENST00000372229.1_Intron|SLC35C2_ENST00000543605.1_Missense_Mutation_p.L87V|SLC35C2_ENST00000243896.2_Missense_Mutation_p.L58V|SLC35C2_ENST00000317734.8_Missense_Mutation_p.L58V|SLC35C2_ENST00000372230.5_Missense_Mutation_p.L58V			Q9NQQ7	S35C2_HUMAN	solute carrier family 35 (GDP-fucose transporter), member C2	58					transport	integral to membrane				cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)	16		Myeloproliferative disorder(115;0.0122)				GCGGAGAAGAGGAAGATCACG	0.617000													19	31					0	0	1	0	0
VNN3	55350	broad.mit.edu	37	6	133048109	133048109	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:133048109C>T	ENST00000367927.5	-	4	652	c.580G>A	c.(580-582)Gat>Aat	p.D194N	VNN3_ENST00000425515.2_3'UTR|VNN3_ENST00000427187.2_Intron|VNN3_ENST00000414302.2_Silent_p.R129R|VNN3_ENST00000275223.3_Intron|VNN3_ENST00000519686.2_Intron|VNN3_ENST00000392393.3_Intron|VNN3_ENST00000417437.2_Intron|VNN3_ENST00000207771.3_Missense_Mutation_p.D194N|VNN3_ENST00000450865.2_Intron|VNN3_ENST00000509351.1_Intron|VNN3_ENST00000423615.2_Intron					vanin 3											cervix(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)|stomach(1)	8	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00242)|GBM - Glioblastoma multiforme(226;0.0168)		AGTTCTGAATCCTTGGGGAAA	0.363000													8	7					0	0	1	0	0
ZNF774	342132	broad.mit.edu	37	15	90902107	90902107	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:90902107C>T	ENST00000354377.3	+	3	315	c.129C>T	c.(127-129)tcC>tcT	p.S43S	ZNF774_ENST00000558115.1_3'UTR|ZNF774_ENST00000379090.5_Silent_p.S43S	NM_001004309.2	NP_001004309.2	Q6NX45	ZN774_HUMAN	zinc finger protein 774	43	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|stomach(1)	14	Melanoma(11;0.00551)|Lung NSC(78;0.0158)|all_lung(78;0.0331)		BRCA - Breast invasive adenocarcinoma(143;0.0224)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			GTGTAATCTCCCAGCCGGAGC	0.512000													8	16					0	0	1	0	0
RTEL1	51750	broad.mit.edu	37	20	62319064	62319064	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:62319064C>T	ENST00000318100.4	+	17	2249	c.1422C>T	c.(1420-1422)tcC>tcT	p.S474S	RTEL1_ENST00000360203.5_Silent_p.S474S|RTEL1_ENST00000370018.3_Silent_p.S474S|RTEL1-TNFRSF6B_ENST00000482936.1_Silent_p.S474S|RTEL1_ENST00000508582.2_Silent_p.S498S			Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	474					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			GCGTCCGCTCCCTCATCCTTA	0.687000													4	8					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10432791	10432791	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:10432791C>A	ENST00000245503.5	-	25	3509	c.3125G>T	c.(3124-3126)gGg>gTg	p.G1042V	MYH2_ENST00000397183.2_Missense_Mutation_p.G1042V|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000399342.2_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1042					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						CTCCAAGGACCCTTCAAGCTA	0.388000													12	28					1.36491e-13	1.39016e-13	1	1	0
TBP	6908	broad.mit.edu	37	6	170871043	170871043	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:170871043G>A	ENST00000392092.2	+	3	498	c.219G>A	c.(217-219)caG>caA	p.Q73Q	TBP_ENST00000230354.6_Silent_p.Q73Q|TBP_ENST00000540980.1_Silent_p.Q53Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	73	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding	p.Q73Q(1)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcagcaacagcaacagcagc	0.562000													4	44					0	0	1	0	0
LRP5L	91355	broad.mit.edu	37	22	25755923	25755923	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr22:25755923C>G	ENST00000444995.3	-	4	837	c.137G>C	c.(136-138)cGa>cCa	p.R46P	LRP5L_ENST00000402859.2_Missense_Mutation_p.R46P|LRP5L_ENST00000402785.2_Missense_Mutation_p.R46P			A4QPB2	LRP5L_HUMAN	low density lipoprotein receptor-related protein 5-like	46										central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(2)	6						ATAGAGGCTTCGGGCCACCCA	0.597000													24	23					0	0	1	0	0
EMILIN2	84034	broad.mit.edu	37	18	2885092	2885092	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr18:2885092C>T	ENST00000254528.3	+	3	547	c.388C>T	c.(388-390)Cgc>Tgc	p.R130C		NM_032048.2	NP_114437.2	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2	130					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(4)	48				READ - Rectum adenocarcinoma(2;0.1)		GAAGACCCTCCGCCCCACGCC	0.517000													11	28					0	0	1	0	0
IRAK2	3656	broad.mit.edu	37	3	10280488	10280488	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:10280488C>T	ENST00000256458.4	+	12	1620	c.1530C>T	c.(1528-1530)ctC>ctT	p.L510L		NM_001570.3	NP_001561.3	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	510					activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			breast(4)|large_intestine(8)|lung(11)|prostate(1)|stomach(1)	25						AGACGTTGCTCCCTTGGAGTG	0.557000													25	45					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79588668	79588668	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:79588668G>A	ENST00000372391.2	-	13	2266	c.2261C>T	c.(2260-2262)tCc>tTc	p.S754F	DLG5_ENST00000372388.2_Missense_Mutation_p.S754F	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	754	PDZ 2.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			CACAGCAAGGGACCCTTCTTT	0.567000													14	26					0	0	1	0	0
ACE	1636	broad.mit.edu	37	17	61568597	61568597	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:61568597G>A	ENST00000577647.1	+	8	1090	c.1045G>A	c.(1045-1047)Gag>Aag	p.E349K	ACE_ENST00000413513.3_Missense_Mutation_p.E349K|ACE_ENST00000428043.1_Missense_Mutation_p.E923K|ACE_ENST00000490216.2_Missense_Mutation_p.E349K|ACE_ENST00000290866.4_Missense_Mutation_p.E923K|ACE_ENST00000290863.6_Missense_Mutation_p.E349K|ACE_ENST00000421982.2_Missense_Mutation_p.E169K			P12821	ACE_HUMAN	angiotensin I converting enzyme	923	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	GATGTTTAAGGAGGCTGATGA	0.632000													8	41					0	0	1	0	0
AGO2	27161	broad.mit.edu	37	8	141542232	141542232	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:141542232A>G	ENST00000220592.5	-	19	2603	c.2491T>C	c.(2491-2493)Tct>Cct	p.S831P	AGO2_ENST00000519980.1_Missense_Mutation_p.S797P	NM_012154.3	NP_036286.2			argonaute RISC catalytic component 2																		CTCTGCCCAGAGGTATGGCTT	0.532000													34	107					0	0	1	0	0
LRFN1	57622	broad.mit.edu	37	19	39805577	39805577	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:39805577G>A	ENST00000248668.4	-	1	399	c.400C>T	c.(400-402)Cgc>Tgc	p.R134C	CTC-246B18.8_ENST00000601911.1_RNA	NM_020862.1	NP_065913.1	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III domain containing 1	134						cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			CCCAGGCCGCGGAGCTGGTCG	0.706000													6	9					0	0	1	0	0
OR1D4	653166	broad.mit.edu	37	17	3144402	3144402	+	RNA	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:3144402C>T	ENST00000531680.1	+	0	433					NR_033795.1				olfactory receptor, family 1, subfamily D, member 4 (gene/pseudogene)																		TGTCTTGCTCCTCTCCTTGTG	0.577000													4	14					0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92471750	92471750	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:92471750G>A	ENST00000267622.4	-	11	2943	c.2570C>T	c.(2569-2571)tCc>tTc	p.S857F		NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	857					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		CTCTTTCATGGATCCAAGACT	0.413000			T	PDGFRB	AML								20	26					0	0	1	0	0
GABPA	2551	broad.mit.edu	37	21	27117662	27117662	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr21:27117662C>T	ENST00000354828.3	+	3	746	c.219C>T	c.(217-219)atC>atT	p.I73I	GABPA_ENST00000400075.3_Silent_p.I73I|GABPA_ENST00000487266.1_3'UTR	NM_001197297.1	NP_001184226.1	Q06546	GABPA_HUMAN	GA binding protein transcription factor, alpha subunit 60kDa	73					positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(5)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	24						TGCAAGATATCCAGGTAATTT	0.318000													6	61					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153056655	153056655	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:153056655G>A	ENST00000285900.5	+	7	1306	c.963G>A	c.(961-963)ggG>ggA	p.G321G	GRIA1_ENST00000340592.5_Silent_p.G321G|GRIA1_ENST00000518783.1_Silent_p.G331G|GRIA1_ENST00000518142.1_Silent_p.G241G|GRIA1_ENST00000521843.2_Silent_p.G252G|GRIA1_ENST00000448073.4_Silent_p.G331G	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	321					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GGAATGCTGGGGATTGTCTGG	0.567000													10	12					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17071902	17071902	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr22:17071902C>T	ENST00000359963.3	-	1	1798	c.1539G>A	c.(1537-1539)caG>caA	p.Q513Q		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	513					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity	p.Q513H(2)		breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CAGTCACGAGCTGTAGCACCA	0.498000													31	52					0	0	1	0	0
PKLR	5313	broad.mit.edu	37	1	155269926	155269926	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:155269926G>A	ENST00000392414.3	-	2	266	c.153C>T	c.(151-153)ccC>ccT	p.P51P	PKLR_ENST00000342741.4_Silent_p.P82P	NM_181871.3	NP_870986.1	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC	82			Missing (in PKRD).		endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	GAGCAGCCACGGGCTCGGAGT	0.582000													19	35					0	0	1	0	0
GLUL	2752	broad.mit.edu	37	1	182356320	182356320	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:182356320C>T	ENST00000311223.5	-	4	1170	c.274G>A	c.(274-276)Gac>Aac	p.D92N	GLUL_ENST00000339526.4_Missense_Mutation_p.D92N|GLUL_ENST00000491322.1_5'UTR|GLUL_ENST00000417584.2_Missense_Mutation_p.D92N|GLUL_ENST00000331872.6_Missense_Mutation_p.D92N	NM_002065.5	NP_002056.2	P15104	GLNA_HUMAN	glutamate-ammonia ligase	92					cell proliferation|glutamine biosynthetic process|neurotransmitter uptake	cytosol|Golgi apparatus|mitochondrion	ATP binding|glutamate decarboxylase activity|glutamate-ammonia ligase activity|identical protein binding			endometrium(2)|large_intestine(5)|lung(8)|upper_aerodigestive_tract(1)	16					Asparaginase(DB00023)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)|L-Methionine(DB00134)	TTGTTAGGGTCCTTACGGAAG	0.478000													28	37					0	0	1	0	0
AMTN	401138	broad.mit.edu	37	4	71396779	71396779	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:71396779C>T	ENST00000339336.4	+	8	511	c.381C>T	c.(379-381)atC>atT	p.I127I	AMTN_ENST00000504451.1_Silent_p.I126I	NM_212557.2	NP_997722.1	Q6UX39	AMTN_HUMAN	amelotin	127					biomineral tissue development|cell adhesion|odontogenesis of dentine-containing tooth	basal lamina|cell-cell junction				NS(3)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|prostate(3)|skin(1)	19			Lung(101;0.235)			CGAGCCTCATCATCCATTCCT	0.488000													9	13					0	0	1	0	0
FAM171B	165215	broad.mit.edu	37	2	187608231	187608231	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:187608231C>T	ENST00000304698.5	+	3	697	c.494C>T	c.(493-495)tCa>tTa	p.S165L		NM_177454.3	NP_803237.3	Q6P995	F171B_HUMAN	family with sequence similarity 171, member B	165						integral to membrane	DNA binding			NS(1)|breast(6)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(22)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						GTTACACTTTCACTGTTCCCG	0.323000													16	29					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11583189	11583189	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:11583189G>C	ENST00000262442.3	+	18	3537	c.3469G>C	c.(3469-3471)Gaa>Caa	p.E1157Q	DNAH9_ENST00000454412.2_Missense_Mutation_p.E1157Q	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1157	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGCTGTTAAAGAACGGCAGAG	0.408000													24	41					0	0	1	0	0
PCNX	22990	broad.mit.edu	37	14	71444132	71444132	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:71444132A>G	ENST00000304743.2	+	6	1524	c.1078A>G	c.(1078-1080)Aaa>Gaa	p.K360E	PCNX_ENST00000238570.5_Missense_Mutation_p.K360E|PCNX_ENST00000439984.3_Missense_Mutation_p.K360E	NM_014982.2	NP_055797.2	Q96RV3	PCX1_HUMAN	pecanex homolog (Drosophila)	360						integral to membrane				NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		TGGGAAGAGCAAACCTTTGAA	0.478000													21	23					0	0	1	0	0
IFNW1	3467	broad.mit.edu	37	9	21141283	21141283	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:21141283G>T	ENST00000380229.2	-	1	861	c.287C>A	c.(286-288)tCc>tAc	p.S96Y		NM_002177.1	NP_002168.1	P05000	IFNW1_HUMAN	interferon, omega 1	96					cell cycle arrest|defense response|response to virus	extracellular space	cytokine activity|cytokine receptor binding			endometrium(1)|kidney(1)|lung(2)|ovary(1)	5				GBM - Glioblastoma multiforme(5;2.35e-185)|Lung(24;2.24e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		GGCAGCAGAGGAGCGCTCTGT	0.547000													17	8					3.41278e-10	3.46372e-10	1	1	0
USP24	23358	broad.mit.edu	37	1	55598327	55598327	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:55598327G>A	ENST00000294383.6	-	31	3427	c.3428C>T	c.(3427-3429)tCc>tTc	p.S1143F	USP24_ENST00000407756.1_Missense_Mutation_p.S983F	NM_015306.2	NP_056121.2	Q9UPU5	UBP24_HUMAN	ubiquitin specific peptidase 24	1143	Ser-rich.				ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|cervix(1)|endometrium(8)|kidney(13)|large_intestine(7)|lung(16)|ovary(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	60						TGATGACAGGGATGGAGATTT	0.393000													7	15					0	0	1	0	0
PIGR	5284	broad.mit.edu	37	1	207110764	207110764	+	Missense_Mutation	SNP	C	C	T	rs137917999		TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:207110764C>T	ENST00000356495.4	-	4	904	c.721G>A	c.(721-723)Gag>Aag	p.E241K		NM_002644.3	NP_002635.2	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor	241				E -> Q (in Ref. 6; AA sequence and 7; AA sequence).		extracellular region|integral to plasma membrane	protein binding			central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						AGCTCGGGCTCGGGCTTTAGC	0.552000													18	25					0	0	1	0	0
PKP1	5317	broad.mit.edu	37	1	201287848	201287848	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:201287848G>A	ENST00000263946.3	+	6	1408	c.1157G>A	c.(1156-1158)tGg>tAg	p.W386*	PKP1_ENST00000475988.1_3'UTR|PKP1_ENST00000367324.3_Nonsense_Mutation_p.W386*|PKP1_ENST00000352845.3_Nonsense_Mutation_p.W386*	NM_000299.3	NP_000290.2	Q13835	PKP1_HUMAN	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	386					cell adhesion|cellular component disassembly involved in apoptosis|multicellular organismal development	desmosome|intermediate filament|nucleus	intermediate filament binding|signal transducer activity|structural constituent of epidermis			NS(2)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(5)|prostate(1)	22						TTCTCTGGCTGGTGCGATGGC	0.572000													9	11					0	0	1	0	0
FAM47E-STBD1	100631383	broad.mit.edu	37	4	77230887	77230887	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:77230887C>T	ENST00000237642.6	+	2	1555	c.811C>T	c.(811-813)Cat>Tat	p.H271Y	FAM47E_ENST00000515604.1_3'UTR|FAM47E-STBD1_ENST00000539752.1_Missense_Mutation_p.H122Y	NM_003943.4	NP_003934.1																					GTTCCAGGTCCATTATGTCAC	0.478000													7	10					0	0	1	0	0
PLEKHA7	144100	broad.mit.edu	37	11	17035708	17035708	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:17035708C>T	ENST00000355661.3	-	2	137	c.127G>A	c.(127-129)Ggg>Agg	p.G43R	PLEKHA7_ENST00000448080.2_Missense_Mutation_p.G43R|PLEKHA7_ENST00000531066.1_Missense_Mutation_p.G43R|PLEKHA7_ENST00000532079.1_Silent_p.P21P|OR7E14P_ENST00000530490.1_RNA			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	43					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						ACGGGCTCCCCGGTGCGCGGA	0.746000													6	6					0	0	1	0	0
RUNDC1	146923	broad.mit.edu	37	17	41142977	41142977	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:41142977C>T	ENST00000361677.1	+	5	1098	c.1086C>T	c.(1084-1086)ggC>ggT	p.G362G		NM_173079.2	NP_775102.2	Q96C34	RUND1_HUMAN	RUN domain containing 1	362										breast(1)|large_intestine(2)|lung(4)|prostate(1)	8		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		GTGCCACAGGCCAGATCCCTC	0.592000													23	25					0	0	1	0	0
DNM3	26052	broad.mit.edu	37	1	172001583	172001583	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:172001583G>A	ENST00000358155.4	+	5	807	c.631G>A	c.(631-633)Gat>Aat	p.D211N	DNM3_ENST00000355305.5_Missense_Mutation_p.D211N|DNM3_ENST00000367731.1_Missense_Mutation_p.D211N|DNM3_ENST00000520906.1_Missense_Mutation_p.D211N|DNM3_ENST00000367733.2_Missense_Mutation_p.D211N	NM_015569.3	NP_056384.2	Q9UQ16	DYN3_HUMAN	dynamin 3	211					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(16)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						GGACCTTATGGATGAAGGAAC	0.383000													29	38					0	0	1	0	0
POLR2B	5431	broad.mit.edu	37	4	57883231	57883231	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:57883231G>A	ENST00000381227.1	+	16	2391	c.1978G>A	c.(1978-1980)Ggg>Agg	p.G660R	POLR2B_ENST00000431623.2_Missense_Mutation_p.G585R|POLR2B_ENST00000441246.2_Missense_Mutation_p.G653R|POLR2B_ENST00000314595.5_Missense_Mutation_p.G660R			P30876	RPB2_HUMAN	polymerase (RNA) II (DNA directed) polypeptide B, 140kDa	660					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(10)|large_intestine(9)|lung(17)|ovary(2)|prostate(4)|skin(1)	52	Glioma(25;0.08)|all_neural(26;0.181)					TGTGGCCAGTGGGGTAGTGGA	0.368000													13	27					0	0	1	0	0
SCLT1	132320	broad.mit.edu	37	4	129924982	129924982	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:129924982G>A	ENST00000281142.5	-	6	843	c.340C>T	c.(340-342)Ccc>Tcc	p.P114S	SCLT1_ENST00000434680.1_Missense_Mutation_p.P114S|SCLT1_ENST00000439369.2_Intron|SCLT1_ENST00000503215.1_Missense_Mutation_p.P91S	NM_144643.2	NP_653244.2	Q96NL6	SCLT1_HUMAN	sodium channel and clathrin linker 1	114						centrosome				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	29						GTGCCCAGGGGAAAGGCCTCC	0.388000													24	25					0	0	1	0	0
LEPR	3953	broad.mit.edu	37	1	66102039	66102039	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:66102039G>A	ENST00000349533.6	+	20	3024	c.2839G>A	c.(2839-2841)Gat>Aat	p.D947N	LEPR_ENST00000406510.3_Missense_Mutation_p.D14N	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	947					energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TTCAACAACAGATCTTGAAAA	0.408000													24	39					0	0	1	0	0
CLDN9	9080	broad.mit.edu	37	16	3063829	3063829	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr16:3063829C>T	ENST00000445369.2	+	1	1373	c.466C>T	c.(466-468)Ctc>Ttc	p.L156F		NM_020982.3	NP_066192.1	O95484	CLD9_HUMAN	claudin 9	156					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(2)|large_intestine(1)|lung(5)|prostate(2)	10						GGCTGAGGCCCTCAAGCGGGA	0.697000													23	22					0	0	1	0	0
TICRR	90381	broad.mit.edu	37	15	90168542	90168542	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:90168542G>A	ENST00000268138.7	+	20	5106	c.5001G>A	c.(4999-5001)tgG>tgA	p.W1667*	KIF7_ENST00000558928.1_Intron|TICRR_ENST00000560985.1_Nonsense_Mutation_p.W1666*					TOPBP1-interacting checkpoint and replication regulator																		GGGTTCCTTGGACACCATCCC	0.597000													22	46					0	0	1	0	0
EPHX2	2053	broad.mit.edu	37	8	27401963	27401963	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:27401963C>T	ENST00000521400.1	+	19	2022	c.1592C>T	c.(1591-1593)cCa>cTa	p.P531L	EPHX2_ENST00000521780.1_Missense_Mutation_p.P465L|EPHX2_ENST00000518379.1_Missense_Mutation_p.P499L|EPHX2_ENST00000517536.1_Missense_Mutation_p.P348L|EPHX2_ENST00000380476.3_Missense_Mutation_p.P478L	NM_001979.5	NP_001970.2	P34913	HYES_HUMAN	epoxide hydrolase 2, cytoplasmic	531	Epoxide hydrolase.				aromatic compound catabolic process|cellular calcium ion homeostasis|drug metabolic process|inflammatory response|positive regulation of vasodilation|reactive oxygen species metabolic process|regulation of blood pressure|response to toxin|xenobiotic metabolic process	cytosol|focal adhesion|Golgi apparatus|nucleolus|peroxisome|soluble fraction	epoxide hydrolase activity|metal ion binding|protein homodimerization activity			cervix(1)|endometrium(8)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|skin(5)|stomach(1)|urinary_tract(1)	27		Ovarian(32;2.61e-05)|all_epithelial(46;0.207)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0226)|Epithelial(17;1.12e-09)|Colorectal(74;0.157)	Tamoxifen(DB00675)	TCCCCCAGGCCAACCGAGGTG	0.527000													35	31					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45458398	45458398	+	RNA	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:45458398C>T	ENST00000548424.1	+	0	448																											TACCTGTTTTCCTTTGGCTCC	0.522000													3	12					0	0	1	0	0
TRAV12-2	28673	broad.mit.edu	37	14	22356172	22356172	+	RNA	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:22356172C>T	ENST00000390437.2	+	0	136																											ACTAGTGATCCTGTGGCTTCA	0.373000													9	7					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152652229	152652229	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:152652229C>T	ENST00000367255.5	-	78	14192	c.13591G>A	c.(13591-13593)Gaa>Aaa	p.E4531K	SYNE1_ENST00000265368.4_Missense_Mutation_p.E4531K|SYNE1_ENST00000448038.1_Missense_Mutation_p.E4460K|SYNE1_ENST00000423061.1_Missense_Mutation_p.E4460K|SYNE1_ENST00000341594.5_Intron	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4531					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCCAGCACTTCACTCTTTTCC	0.463000										HNSCC(10;0.0054)			60	61					0	0	1	0	0
TRPC3	7222	broad.mit.edu	37	4	122853785	122853785	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:122853785G>A	ENST00000264811.5	-	1	827	c.409C>T	c.(409-411)Ccc>Tcc	p.P137S	TRPC3_ENST00000513531.1_Missense_Mutation_p.P137S|TRPC3_ENST00000379645.3_Missense_Mutation_p.P210S	NM_003305.2	NP_003296.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	125					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						TGCTCACAGGGGCTCAGAGTG	0.652000													17	18					0	0	1	0	0
ZIM2	23619	broad.mit.edu	37	19	57286577	57286577	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:57286577G>A	ENST00000391708.3	-	12	1605	c.1063C>T	c.(1063-1065)Ccc>Tcc	p.P355S	ZIM2_ENST00000593711.1_Missense_Mutation_p.P355S|AC006115.3_ENST00000594400.1_RNA|AC006115.3_ENST00000597946.1_RNA|AC006115.3_ENST00000595954.1_RNA|ZIM2_ENST00000601070.1_Missense_Mutation_p.P355S|ZIM2_ENST00000221722.5_Missense_Mutation_p.P355S|ZIM2_ENST00000599935.1_Missense_Mutation_p.P355S	NM_001146326.1|NM_001146327.1	NP_001139798.1|NP_001139799.1			zinc finger, imprinted 2											NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		CATTCATAGGGTTTCTTCCCA	0.448000													19	38					0	0	1	0	0
CDYL2	124359	broad.mit.edu	37	16	80718715	80718715	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr16:80718715G>A	ENST00000299564.8	-	2	491	c.336C>T	c.(334-336)ccC>ccT	p.P112P	CDYL2_ENST00000566173.1_Silent_p.P112P|CDYL2_ENST00000562753.1_5'UTR|CDYL2_ENST00000563890.1_Silent_p.P112P|CDYL2_ENST00000562812.1_Silent_p.P112P	NM_152342.2	NP_689555.2	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	112						nucleus	catalytic activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	21						GCTTGGCCAGGGGAGGGTTAA	0.547000													11	10					0	0	1	0	0
ASXL2	55252	broad.mit.edu	37	2	25972930	25972930	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:25972930G>T	ENST00000435504.4	-	12	1788	c.1495C>A	c.(1495-1497)Cag>Aag	p.Q499K	ASXL2_ENST00000272341.4_Missense_Mutation_p.Q239K|ASXL2_ENST00000336112.4_Missense_Mutation_p.Q471K|ASXL2_ENST00000404843.1_Missense_Mutation_p.Q239K			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	499					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCAGATTCCTGTTCAGCAGAG	0.453000													39	62					6.29468e-14	6.4168e-14	1	1	0
SNHG14	104472715	broad.mit.edu	37	15	25446294	25446294	+	RNA	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:25446294G>A	ENST00000424208.1	+	0	1869				SNHG14_ENST00000424333.1_RNA	NR_003305.1																						CTGTGAAATGGGAGGAAGAAT	0.557000													12	8					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857384	9857384	+	Silent	SNP	T	T	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr16:9857384T>C	ENST00000396573.2	-	14	4326	c.4017A>G	c.(4015-4017)aaA>aaG	p.K1339K	GRIN2A_ENST00000404927.2_Intron|GRIN2A_ENST00000535259.1_Intron|GRIN2A_ENST00000330684.3_Silent_p.K1339K|GRIN2A_ENST00000562109.1_Intron|GRIN2A_ENST00000396575.2_Silent_p.K1339K	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1339					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GGGAGCTTTTTTTCCCCGAGA	0.557000													25	28					0	0	1	0	0
GPR125	166647	broad.mit.edu	37	4	22415324	22415324	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:22415324G>A	ENST00000334304.5	-	13	2192	c.1923C>T	c.(1921-1923)ttC>ttT	p.F641F	GPR125_ENST00000282943.5_5'UTR	NM_145290.2	NP_660333.2	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125	641					neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(33)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	56		Breast(46;0.198)				TTCCATTGCGGAATGCAATGA	0.423000													16	33					0	0	1	0	0
FAM129A	116496	broad.mit.edu	37	1	184859248	184859248	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:184859248G>A	ENST00000367511.3	-	4	620	c.427C>T	c.(427-429)Cct>Tct	p.P143S		NM_052966.2	NP_443198.1	Q9BZQ8	NIBAN_HUMAN	family with sequence similarity 129, member A	143					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(6)|liver(1)|lung(22)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	45						TCACCAAGAGGGTCTGGGAAA	0.458000													11	13					0	0	1	0	0
PVR	5817	broad.mit.edu	37	19	45162022	45162022	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:45162022G>T	ENST00000425690.3	+	6	1303	c.1004G>T	c.(1003-1005)aGt>aTt	p.S335I	PVR_ENST00000403059.4_Missense_Mutation_p.S335I|CTB-171A8.1_ENST00000590796.1_RNA|PVR_ENST00000406449.4_Missense_Mutation_p.S335I|PVR_ENST00000344956.4_Intron	NM_006505.3	NP_006496.3	P15151	PVR_HUMAN	poliovirus receptor	335					adherens junction organization|cell adhesion|cell junction assembly|interspecies interaction between organisms|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity	cell junction|cell surface|cytoplasm|extracellular space|integral to membrane|nucleus	cell adhesion molecule binding|receptor activity			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	6	Lung NSC(12;0.00608)|all_lung(12;0.0148)	Medulloblastoma(540;0.0425)|Ovarian(192;0.0728)|Prostate(69;0.081)|all_neural(266;0.112)		Epithelial(262;0.000601)		GGACCTCCCAGTGAGCACTCA	0.463000													46	40					1.21353e-23	1.24476e-23	1	1	0
MYCBPAP	84073	broad.mit.edu	37	17	48601045	48601045	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:48601045G>A	ENST00000323776.5	+	12	1826	c.1664G>A	c.(1663-1665)cGa>cAa	p.R555Q	MYCBPAP_ENST00000436259.2_Missense_Mutation_p.R518Q	NM_032133.4	NP_115509.4	Q8TBZ2	MYBPP_HUMAN	MYCBP associated protein	518					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(8)|ovary(4)|pancreas(1)|skin(2)|urinary_tract(2)	31	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			TGGGAGTTTCGAACCCATCCT	0.478000													11	20					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47855918	47855918	+	Silent	SNP	C	C	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr21:47855918C>G	ENST00000359568.5	+	39	8960	c.8853C>G	c.(8851-8853)cgC>cgG	p.R2951R	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	2951					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					CTGGCAGCCGCCTCCACCTAG	0.622000													38	73					0	0	1	0	0
SMARCA4	6597	broad.mit.edu	37	19	11143993	11143993	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:11143993C>T	ENST00000358026.2	+	26	3858	c.3574C>T	c.(3574-3576)Cgc>Tgc	p.R1192C	SMARCA4_ENST00000444061.3_Missense_Mutation_p.R1192C|SMARCA4_ENST00000344626.4_Missense_Mutation_p.R1192C|SMARCA4_ENST00000413806.3_Missense_Mutation_p.R1192C|SMARCA4_ENST00000541122.2_Missense_Mutation_p.R1192C|SMARCA4_ENST00000590574.1_Missense_Mutation_p.R1192C|SMARCA4_ENST00000429416.3_Missense_Mutation_p.R1192C|SMARCA4_ENST00000589677.1_Missense_Mutation_p.R1192C|SMARCA4_ENST00000450717.3_Missense_Mutation_p.R1192C	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	1192	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.R1192C(1)|p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CCGAGCCCACCGCATCGGGCA	0.607000			"""F, N, Mis"""		NSCLC								51	69					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8657671	8657671	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:8657671G>C	ENST00000270328.4	-	12	1829	c.1563C>G	c.(1561-1563)tgC>tgG	p.C521W	ADAMTS10_ENST00000597188.1_Missense_Mutation_p.C521W			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	521	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						TGTGCGTCTGGCACAGCGTGC	0.711000													16	21					0	0	1	0	0
HDAC4	9759	broad.mit.edu	37	2	240016726	240016726	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:240016726G>A	ENST00000345617.3	-	17	3036	c.2245C>T	c.(2245-2247)Ctc>Ttc	p.L749F	HDAC4_ENST00000543185.1_Missense_Mutation_p.L333F|HDAC4_ENST00000541256.1_Missense_Mutation_p.L723F	NM_006037.3	NP_006028.2	P56524	HDAC4_HUMAN	histone deacetylase 4	749	Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(5)	62		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		CCGCAAGGGAGCCGGACGAAC	0.602000													29	12					0	0	1	0	0
ALOX15	246	broad.mit.edu	37	17	4542748	4542748	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:4542748A>T	ENST00000570836.1	-	3	410	c.314T>A	c.(313-315)gTc>gAc	p.V105D	ALOX15_ENST00000545513.1_Missense_Mutation_p.V127D|ALOX15_ENST00000293761.3_Missense_Mutation_p.V105D|ALOX15_ENST00000574640.1_Missense_Mutation_p.V66D			P16050	LOX15_HUMAN	arachidonate 15-lipoxygenase	105	PLAT.				inflammatory response|leukotriene biosynthetic process	nucleus	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(5)	20				READ - Rectum adenocarcinoma(115;0.0327)	Ciclopirox(DB01188)|Masoprocol(DB00179)|Zileuton(DB00744)	CAGGCTCAGGACGCCGTTGCC	0.662000													14	28					0	0	1	0	0
MRVI1	10335	broad.mit.edu	37	11	10645339	10645339	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:10645339G>A	ENST00000547195.1	-	9	1660	c.1160C>T	c.(1159-1161)gCt>gTt	p.A387V	MRVI1_ENST00000423302.2_Missense_Mutation_p.A478V|MRVI1_ENST00000534266.2_Missense_Mutation_p.A163V|MRVI1_ENST00000527509.2_Missense_Mutation_p.A387V|MRVI1_ENST00000424001.1_Missense_Mutation_p.A163V|MRVI1_ENST00000421747.1_Missense_Mutation_p.A469V|MRVI1_ENST00000545852.1_Missense_Mutation_p.A163V|MRVI1_ENST00000541483.1_Missense_Mutation_p.A272V|MRVI1_ENST00000558540.1_Missense_Mutation_p.A163V|MRVI1_ENST00000436272.1_Missense_Mutation_p.A451V|MRVI1_ENST00000531107.1_Missense_Mutation_p.A470V|MRVI1_ENST00000552103.1_Missense_Mutation_p.A387V	NM_001100163.2|NM_001206881.1	NP_001093633.1|NP_001193810.1	Q9Y6F6	MRVI1_HUMAN	murine retrovirus integration site 1 homolog	451					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		TTCCTGCTCAGCTGCTTCACT	0.463000													9	19					0	0	1	0	0
AMIGO2	347902	broad.mit.edu	37	12	47471750	47471750	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:47471750C>T	ENST00000266581.4	-	2	1502	c.1036G>A	c.(1036-1038)Gga>Aga	p.G346R	AMIGO2_ENST00000321382.3_Missense_Mutation_p.G346R|AMIGO2_ENST00000550413.1_Missense_Mutation_p.G346R|AMIGO2_ENST00000429635.1_Missense_Mutation_p.G346R	NM_181847.4	NP_862830.1	Q86SJ2	AMGO2_HUMAN	adhesion molecule with Ig-like domain 2	346	Ig-like C2-type.				heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane				endometrium(2)|kidney(1)|large_intestine(8)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Renal(347;0.138)|Lung SC(27;0.192)					ACCAGACTTCCATTGTGAAAC	0.428000													33	48					0	0	1	0	0
TSPAN6	7105	broad.mit.edu	37	X	99890734	99890734	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:99890734C>T	ENST00000373020.4	-	2	208	c.97G>A	c.(97-99)Gtt>Att	p.V33I	TSPAN6_ENST00000496771.1_5'UTR	NM_003270.2	NP_003261.1	O43657	TSN6_HUMAN	tetraspanin 6	33					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	signal transducer activity			endometrium(2)|kidney(3)|large_intestine(6)|ovary(1)	12						AGAAGGATAACGCCAGTGATC	0.443000													4	0					0	0	1	0	0
BNC2	54796	broad.mit.edu	37	9	16436876	16436876	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:16436876C>T	ENST00000380672.4	-	6	1373	c.1316G>A	c.(1315-1317)gGa>gAa	p.G439E	BNC2_ENST00000545497.1_Missense_Mutation_p.G344E|BNC2_ENST00000380666.2_Missense_Mutation_p.G439E|BNC2_ENST00000380667.2_Missense_Mutation_p.G372E	NM_017637.5	NP_060107.3	Q6ZN30	BNC2_HUMAN	basonuclin 2	439					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(16)|liver(1)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(50;9.01e-08)		GAACACTCTTCCTTTCCTAGA	0.438000													11	5					0	0	1	0	0
CTBP1-AS2	92070	broad.mit.edu	37	4	1244740	1244740	+	RNA	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:1244740C>T	ENST00000581398.1	+	0	694				CTBP1-AS2_ENST00000578730.1_RNA|CTBP1-AS2_ENST00000514984.1_RNA|CTBP1-AS2_ENST00000357591.2_RNA	NR_033339.1																						CTCCAGGATCCACTTCCTGCG	0.567000													12	14					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32633018	32633018	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:32633018G>A	ENST00000242310.4	-	1	2649	c.2560C>T	c.(2560-2562)Cct>Tct	p.P854S		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	854					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GAATGGGAAGGAAAGGCTTTT	0.443000													18	41					0	0	1	0	0
CPT1C	126129	broad.mit.edu	37	19	50208484	50208484	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:50208484G>A	ENST00000392518.4	+	10	1265	c.893G>A	c.(892-894)gGa>gAa	p.G298E	CPT1C_ENST00000405931.2_Missense_Mutation_p.G287E|CPT1C_ENST00000598293.1_Missense_Mutation_p.G298E|CPT1C_ENST00000323446.5_Missense_Mutation_p.G298E|CPT1C_ENST00000354199.5_Missense_Mutation_p.G298E	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	298					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		TTGCTGATGGGAATGCGCCCC	0.587000													34	75					0	0	1	0	0
DNAJC3	5611	broad.mit.edu	37	13	96415967	96415967	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr13:96415967C>T	ENST00000602402.1	+	8	1036	c.919C>T	c.(919-921)Cgt>Tgt	p.R307C	DNAJC3_ENST00000376795.6_Missense_Mutation_p.R256C	NM_006260.4	NP_006251.1	Q13217	DNJC3_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 3	307					protein folding|response to unfolded protein|response to virus		heat shock protein binding|protein kinase inhibitor activity|unfolded protein binding			NS(1)|breast(1)|kidney(4)|large_intestine(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.126)			ATATACAGTTCGTTCAAAGGA	0.368000													56	8					0	0	1	0	0
IQSEC3	440073	broad.mit.edu	37	12	247436	247436	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:247436G>A	ENST00000538872.1	+	4	1025	c.907G>A	c.(907-909)Gaa>Aaa	p.E303K	IQSEC3_ENST00000382841.2_5'UTR|RP11-598F7.4_ENST00000505893.2_RNA|IQSEC3_ENST00000326261.4_Missense_Mutation_p.E303K			Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	303					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		CTTGCAGATTGAAATGCTAGA	0.602000													13	19					0	0	1	0	0
MAN2A1	4124	broad.mit.edu	37	5	109159485	109159485	+	Missense_Mutation	SNP	T	T	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:109159485T>G	ENST00000261483.4	+	16	3565	c.2513T>G	c.(2512-2514)gTg>gGg	p.V838G		NM_002372.2	NP_002363.2	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	838					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		TATTCGGAAGTGACTTGCTTT	0.338000													24	31					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147964138	147964138	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:147964138C>T	ENST00000361727.3	+	21	3911	c.3395C>T	c.(3394-3396)cCt>cTt	p.P1132L	CNTNAP2_ENST00000538075.1_Missense_Mutation_p.P191L	NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	1132	Laminin G-like 4.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GATCATTATCCTTCTGTGAGT	0.458000										HNSCC(39;0.1)			50	38					0	0	1	0	0
HNF4G	3174	broad.mit.edu	37	8	76463718	76463718	+	Missense_Mutation	SNP	C	C	T	rs147422598		TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:76463718C>T	ENST00000396423.2	+	4	572	c.448C>T	c.(448-450)Cgg>Tgg	p.R150W	HNF4G_ENST00000354370.1_Missense_Mutation_p.R113W	NM_004133.4	NP_004124.4	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	113					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	37	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			AGCTGAAGTTCGGTCTCGCCA	0.423000													5	27					0	0	1	0	0
ZNF488	118738	broad.mit.edu	37	10	48371279	48371279	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:48371279C>T	ENST00000395702.2	+	2	974	c.747C>T	c.(745-747)ccC>ccT	p.P249P	ZNF488_ENST00000494156.1_3'UTR|ZNF488_ENST00000586537.1_Silent_p.P142P			Q96MN9	ZN488_HUMAN	zinc finger protein 488	249			P -> S (in dbSNP:rs3814160).		regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|ovary(2)	14						CCCAGGTGCCCCCACCCTCAT	0.587000													20	16					0	0	1	0	0
SERPINB13	5275	broad.mit.edu	37	18	61260157	61260157	+	Missense_Mutation	SNP	G	G	A	rs138290904		TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr18:61260157G>A	ENST00000344731.5	+	5	526	c.424G>A	c.(424-426)Gat>Aat	p.D142N	SERPINB13_ENST00000269489.5_Missense_Mutation_p.D142N	NM_012397.3	NP_036529.1	Q9UIV8	SPB13_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 13	142					regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						AAATGCAGCCGATGAAAGTCG	0.323000													21	45					0	0	1	0	0
OSCP1	127700	broad.mit.edu	37	1	36888436	36888436	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:36888436C>T	ENST00000356637.5	-	7	775	c.712G>A	c.(712-714)Gtc>Atc	p.V238I	OSCP1_ENST00000495222.1_5'UTR|OSCP1_ENST00000235532.5_Missense_Mutation_p.V228I|OSCP1_ENST00000433045.2_Missense_Mutation_p.V183I|OSCP1_ENST00000315643.9_Missense_Mutation_p.V238I			Q8WVF1	OSCP1_HUMAN	organic solute carrier partner 1	238					transport	basal plasma membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	22						GGTGCAGGGACATAGTTTCCA	0.393000													26	33					0	0	1	0	0
FIGF	2277	broad.mit.edu	37	X	15371246	15371246	+	Missense_Mutation	SNP	T	T	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:15371246T>G	ENST00000297904.3	-	5	1115	c.686A>C	c.(685-687)gAt>gCt	p.D229A		NM_004469.4	NP_004460.1	O43915	VEGFD_HUMAN	c-fos induced growth factor (vascular endothelial growth factor D)	229	4 X 16 AA repeats of C-X(10)-C-X-C- X(1,3)-C.				angiogenesis|cell differentiation|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of mast cell chemotaxis|vascular endothelial growth factor receptor signaling pathway	extracellular space|membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity|platelet-derived growth factor receptor binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	17	Hepatocellular(33;0.183)					TTTGTTGCTATCCCATAGCAT	0.328000													18	27					0	0	1	0	0
SETD2	29072	broad.mit.edu	37	3	47084151	47084151	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:47084151G>C	ENST00000409792.3	-	17	7180	c.7138C>G	c.(7138-7140)Ccc>Gcc	p.P2380A		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	2380					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding	p.P2380fs(2)|p.P1877fs(2)|p.S1879fs*47(1)|p.S2382fs*47(1)		breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		GGAGAGGGGGGCGGCAGATCC	0.428000			"""N, F, S, Mis"""		clear cell renal carcinoma								19	61					0	0	1	0	0
CD33	945	broad.mit.edu	37	19	51728627	51728627	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:51728627G>A	ENST00000262262.4	+	2	212	c.191G>A	c.(190-192)gGa>gAa	p.G64E	CD33_ENST00000436584.2_Intron|CD33_ENST00000421133.2_Intron|CD33_ENST00000391796.3_Missense_Mutation_p.G64E	NM_001772.3	NP_001763.3	P20138	CD33_HUMAN	CD33 molecule	64	Ig-like V-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(15)|skin(1)|stomach(1)	24		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	TTCCGGGAAGGAGCCATTATA	0.537000													52	38					0	0	1	0	0
VWA3B	200403	broad.mit.edu	37	2	98844724	98844724	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:98844724G>C	ENST00000477737.1	+	15	2283	c.2079G>C	c.(2077-2079)aaG>aaC	p.K693N		NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	693										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						ATCTGGAGAAGATGCAAGACC	0.438000													18	19					0	0	1	0	0
CD3G	917	broad.mit.edu	37	11	118221328	118221328	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:118221328C>T	ENST00000532917.1	+	4	437	c.369C>T	c.(367-369)atC>atT	p.I123I	CD3G_ENST00000392883.2_Intron|CD3G_ENST00000532903.1_3'UTR	NM_000073.2	NP_000064.1	P09693	CD3G_HUMAN	CD3g molecule, gamma (CD3-TCR complex)	123					establishment or maintenance of cell polarity|protein complex assembly|protein transport|regulation of apoptosis|T cell activation|T cell costimulation|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	protein heterodimerization activity|receptor signaling complex scaffold activity|T cell receptor binding|transmembrane receptor activity			breast(2)|kidney(1)|large_intestine(2)|skin(1)	6	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		TTGCTGAAATCGTCAGCATTT	0.463000													16	38					0	0	1	0	0
TANC1	85461	broad.mit.edu	37	2	160053229	160053229	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:160053229C>T	ENST00000263635.6	+	18	3327	c.3090C>T	c.(3088-3090)ccC>ccT	p.P1030P	TANC1_ENST00000454300.1_Silent_p.P924P	NM_001145909.1|NM_033394.2	NP_001139381.1|NP_203752.2	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	1030						cell junction|postsynaptic density|postsynaptic membrane	binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(25)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	77						CGGGTCCTCCCCAGCCAGGCA	0.667000													12	31					0	0	1	0	0
ZFYVE19	84936	broad.mit.edu	37	15	41105055	41105055	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:41105055C>G	ENST00000355341.4	+	7	1486	c.985C>G	c.(985-987)Ctg>Gtg	p.L329V	ZFYVE19_ENST00000299173.10_Intron|ZFYVE19_ENST00000564258.1_Missense_Mutation_p.L154V|ZFYVE19_ENST00000570108.1_Missense_Mutation_p.L306V|ZFYVE19_ENST00000336455.5_Missense_Mutation_p.L319V	NM_001077268.1	NP_001070736.1	Q96K21	ZFY19_HUMAN	zinc finger, FYVE domain containing 19	329							zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	9		all_cancers(109;3.31e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.76e-05)|COAD - Colon adenocarcinoma(120;0.151)|BRCA - Breast invasive adenocarcinoma(123;0.164)		GATTCTGGCCCTGGCCAAGCG	0.632000													21	60					0	0	1	0	0
ABCB9	23457	broad.mit.edu	37	12	123425463	123425463	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:123425463G>A	ENST00000542678.1	-	8	4298	c.1460C>T	c.(1459-1461)cCg>cTg	p.P487L	ABCB9_ENST00000442833.2_Missense_Mutation_p.P487L|ABCB9_ENST00000442028.2_Missense_Mutation_p.P487L|ABCB9_ENST00000280560.8_Missense_Mutation_p.P487L|ABCB9_ENST00000541983.1_5'UTR|ABCB9_ENST00000392439.3_Missense_Mutation_p.P487L|ABCB9_ENST00000346530.5_Missense_Mutation_p.P444L|ABCB9_ENST00000540285.1_Intron|ABCB9_ENST00000344275.7_Missense_Mutation_p.P487L			Q9NP78	ABCB9_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 9	487					positive regulation of T cell mediated cytotoxicity|protein transport	lysosomal membrane|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(1)|skin(1)	18	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.84e-05)|Epithelial(86;0.000152)|BRCA - Breast invasive adenocarcinoma(302;0.111)		CACCATGGTCGGCTGCCGGTC	0.647000													3	8					0	0	1	0	0
AK9	221264	broad.mit.edu	37	6	109819057	109819057	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:109819057G>A	ENST00000424296.2	-	37	5234	c.5158C>T	c.(5158-5160)Cct>Tct	p.P1720S	RP5-919F19.5_ENST00000423747.1_RNA	NM_001145128.2	NP_001138600.2			adenylate kinase 9																		GCACACTTAGGGAATCGACTC	0.498000													19	35					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140552978	140552978	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:140552978G>A	ENST00000231137.3	+	1	736	c.562G>A	c.(562-564)Ggg>Agg	p.G188R		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		188	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TAGCGGGGAGGGGAATATCTA	0.493000													24	12					0	0	1	0	0
SHQ1	55164	broad.mit.edu	37	3	72891523	72891523	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:72891523G>A	ENST00000325599.8	-	3	378	c.239C>T	c.(238-240)aCc>aTc	p.T80I	SHQ1_ENST00000463369.1_Missense_Mutation_p.T52I	NM_018130.2	NP_060600.2	Q6PI26	SHQ1_HUMAN	SHQ1, H/ACA ribonucleoprotein assembly factor	80	CS.				ribonucleoprotein complex assembly	cytosol|nucleoplasm	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	27		Prostate(10;0.00482)|Lung NSC(201;0.0339)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;9.68e-05)|Epithelial(33;0.000563)|LUSC - Lung squamous cell carcinoma(21;0.00229)|Lung(16;0.00688)|KIRC - Kidney renal clear cell carcinoma(39;0.018)|Kidney(39;0.0213)		CTGGCCAGGGGTTTCTTTGGG	0.388000													13	20					0	0	1	0	0
ASPH	444	broad.mit.edu	37	8	62415997	62415997	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:62415997G>A	ENST00000541428.1	-	25	2271	c.2111C>T	c.(2110-2112)tCt>tTt	p.S704F	ASPH_ENST00000379454.4_Missense_Mutation_p.S733F	NM_001164750.1	NP_001158222.1	Q12797	ASPH_HUMAN	aspartate beta-hydroxylase	733					muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			breast(1)|cervix(1)|endometrium(5)|large_intestine(5)|lung(16)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)	CAGCCGGAAAGATGAGGCATC	0.507000													7	17					0	0	1	0	0
ATR	545	broad.mit.edu	37	3	142217587	142217587	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:142217587G>A	ENST00000350721.4	-	32	5531	c.5410C>T	c.(5410-5412)Ctg>Ttg	p.L1804L	ATR_ENST00000383101.3_Silent_p.L1740L	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	1804	FAT.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						AGCTGTCCCAGTCTGACACTC	0.383000								Other conserved DNA damage response genes					9	12					0	0	1	0	0
DDX26B	203522	broad.mit.edu	37	X	134709067	134709067	+	Silent	SNP	A	A	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:134709067A>G	ENST00000370752.4	+	13	2023	c.1689A>G	c.(1687-1689)acA>acG	p.T563T	DDX26B_ENST00000493637.1_3'UTR	NM_182540.4	NP_872346.3	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B	563										large_intestine(1)|lung(8)	9	Acute lymphoblastic leukemia(192;6.56e-05)					ATCTGAAGACATTGGCTTCTC	0.408000													47	15					0	0	1	0	0
RGS3	5998	broad.mit.edu	37	9	116356775	116356775	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:116356775C>T	ENST00000374140.2	+	23	3355	c.3146C>T	c.(3145-3147)cCc>cTc	p.P1049L	RGS3_ENST00000342620.5_Missense_Mutation_p.P19L|RGS3_ENST00000374134.3_Missense_Mutation_p.P370L|RGS3_ENST00000350696.5_Missense_Mutation_p.P1049L|RGS3_ENST00000343817.5_Missense_Mutation_p.P768L|RGS3_ENST00000462403.1_Missense_Mutation_p.P162L|RGS3_ENST00000394646.3_Missense_Mutation_p.P442L|RGS3_ENST00000462143.1_Missense_Mutation_p.P370L	NM_144488.4	NP_652759.3	P49796	RGS3_HUMAN	regulator of G-protein signaling 3	1049					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			cervix(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	48						GGAGCCCCTCCCGCGGGCAAG	0.587000													19	14					0	0	1	0	0
GRIP2	80852	broad.mit.edu	37	3	14535325	14535325	+	RNA	SNP	C	C	G	rs79010943	byFrequency	TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:14535325C>G	ENST00000273083.3	-	0	3044							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						CGTGTACGGACGTGGTTGACC	0.607000													14	10					0	0	1	0	0
OR4M2	390538	broad.mit.edu	37	15	22369472	22369472	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:22369472C>T	ENST00000332663.2	+	1	995	c.897C>T	c.(895-897)gcC>gcT	p.A299A	RP11-69H14.6_ENST00000558896.1_RNA	NM_001004719.2	NP_001004719.2	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M, member 2	299					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(38)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	63		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TAAAGGCAGCCATGAGGAAGT	0.348000													5	52					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50929197	50929197	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr18:50929197G>A	ENST00000442544.2	+	19	3485	c.2869G>A	c.(2869-2871)Gaa>Aaa	p.E957K	DCC_ENST00000581580.1_Missense_Mutation_p.E592K|DCC_ENST00000412726.1_Missense_Mutation_p.E785K	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	957	Fibronectin type-III 6.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CATTACTAGGGAAGGGAAGCC	0.493000													22	39					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65233446	65233446	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:65233446G>A	ENST00000389722.3	-	31	6396	c.6343C>T	c.(6343-6345)Ccg>Tcg	p.P2115S	SPTB_ENST00000542895.1_Missense_Mutation_p.P2115S|SPTB_ENST00000556626.1_Missense_Mutation_p.P2115S|SPTB_ENST00000389720.3_Missense_Mutation_p.P2098L|SPTB_ENST00000389721.5_Missense_Mutation_p.P2115S	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	2115					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		AGACTGACCGGGGACGTTCTC	0.592000													43	62					0	0	1	0	0
SMTNL2	342527	broad.mit.edu	37	17	4498564	4498564	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:4498564G>A	ENST00000389313.4	+	5	998	c.931G>A	c.(931-933)Gag>Aag	p.E311K	SMTNL2_ENST00000338859.4_Missense_Mutation_p.E167K	NM_001114974.1	NP_001108446.1	Q2TAL5	SMTL2_HUMAN	smoothelin-like 2	311										breast(1)|endometrium(9)|kidney(1)|lung(1)|skin(1)	13				READ - Rectum adenocarcinoma(115;0.0325)		CCGCACCTCGGAGGCGCAGGC	0.687000													15	18					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48750989	48750989	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:48750989G>A	ENST00000285238.8	+	19	2649	c.2569G>A	c.(2569-2571)Gac>Aac	p.D857N		NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	857					bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	CCCCGATGAGGACCAAGGGCA	0.612000													13	19					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70527625	70527625	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:70527625C>T	ENST00000381269.2	-	3	2569	c.1816G>A	c.(1816-1818)Gag>Aag	p.E606K	SLC8A3_ENST00000216568.7_5'UTR|SLC8A3_ENST00000357887.3_Intron|SLC8A3_ENST00000356921.2_Missense_Mutation_p.E606K|SLC8A3_ENST00000534137.1_Missense_Mutation_p.E606K|SLC8A3_ENST00000533541.1_Intron|SLC8A3_ENST00000533899.1_5'UTR|SLC8A3_ENST00000394330.2_Intron|SLC8A3_ENST00000528359.1_Intron	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	606	Calx-beta 2.				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TCGTATTCCTCCTCATCTACT	0.438000													14	16					0	0	1	0	0
ANO5	203859	broad.mit.edu	37	11	22261174	22261174	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:22261174C>T	ENST00000324559.8	+	9	1139	c.822C>T	c.(820-822)caC>caT	p.H274H		NM_001142649.1|NM_213599.2	NP_001136121.1|NP_998764.1	Q75V66	ANO5_HUMAN	anoctamin 5	274						chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(12)|lung(36)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						ACACACTTCACCAGAATTGGG	0.398000													31	55					0	0	1	0	0
SH3TC1	54436	broad.mit.edu	37	4	8221114	8221114	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:8221114G>A	ENST00000539824.1	+	9	1115	c.741G>A	c.(739-741)gaG>gaA	p.E247E	SH3TC1_ENST00000245105.3_Silent_p.E323E			Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	323							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						GGCCCGAAGAGATGACCTTCC	0.682000													28	34					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S165S|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								4	57					0	0	1	0	0
PKD2L1	9033	broad.mit.edu	37	10	102054364	102054364	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:102054364G>A	ENST00000318222.3	-	9	1969	c.1587C>T	c.(1585-1587)atC>atT	p.I529I	PKD2L1_ENST00000338519.3_Silent_p.I454I|PKD2L1_ENST00000353274.3_Silent_p.I529I	NM_001253837.1|NM_016112.2	NP_001240766.1|NP_057196.2	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	529					signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			NS(2)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	43		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		TGGCATTGTCGATAGCATTGT	0.542000													25	43					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	104709460	104709460	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:104709460G>C	ENST00000406091.3	+	2	323	c.323G>C	c.(322-324)tGt>tCt	p.C108S		NM_001100117.2	NP_001093587.1	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	139	RabBD.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding	p.C108F(1)|p.C144F(1)		NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GGCCATAACTGTTCATATTGC	0.428000										HNSCC(12;0.0054)			52	80					0	0	1	0	0
TRIM3	10612	broad.mit.edu	37	11	6477533	6477533	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:6477533G>A	ENST00000525074.1	-	6	1817	c.1423C>T	c.(1423-1425)Cgt>Tgt	p.R475C	TRIM3_ENST00000345851.3_Missense_Mutation_p.R475C|TRIM3_ENST00000529058.1_Intron|TRIM3_ENST00000359518.3_Missense_Mutation_p.R475C|TRIM3_ENST00000537602.1_Missense_Mutation_p.R397C|TRIM3_ENST00000536344.1_Missense_Mutation_p.R356C	NM_001248006.1	NP_001234935.1	O75382	TRIM3_HUMAN	tripartite motif containing 3	475					nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(3)	27		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTACCAACACGGAAGACGAGC	0.572000													22	43					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126370646	126370646	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:126370646G>A	ENST00000394329.3	+	9	8488	c.8475G>A	c.(8473-8475)ggG>ggA	p.G2825G	FAT4_ENST00000335110.5_Silent_p.G1123G	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2825	Cadherin 27.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CCAGCACAGGGGATATTGTCA	0.403000													23	35					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24193072	24193072	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:24193072C>T	ENST00000265769.4	+	14	1595	c.1485C>T	c.(1483-1485)ttC>ttT	p.F495F	RP11-624C23.1_ENST00000518988.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA|ADAM28_ENST00000437154.2_Silent_p.F495F|RP11-624C23.1_ENST00000519689.1_RNA|RP11-624C23.1_ENST00000523700.1_RNA|ADAM28_ENST00000397649.3_Silent_p.F242F|ADAM28_ENST00000540823.1_Silent_p.F262F	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	495	Cys-rich.				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		TCAATGGCTTCCCTTGCCATC	0.522000													8	13					0	0	1	0	0
PCDHB15	56121	broad.mit.edu	37	5	140627314	140627314	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:140627314G>A	ENST00000231173.3	+	1	2168	c.2168G>A	c.(2167-2169)gGt>gAt	p.G723D		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		723					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCTCAGTGGGTCGCTGCTCG	0.652000													69	119					0	0	1	0	0
BRCA1	672	broad.mit.edu	37	17	41245054	41245054	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:41245054G>A	ENST00000309486.4	-	9	2633	c.1606C>T	c.(1606-1608)Cca>Tca	p.P536S	BRCA1_ENST00000471181.2_Missense_Mutation_p.P832S|BRCA1_ENST00000354071.3_Missense_Mutation_p.P832S|BRCA1_ENST00000493795.1_Missense_Mutation_p.P785S|BRCA1_ENST00000468300.1_Intron|BRCA1_ENST00000351666.3_Intron|BRCA1_ENST00000346315.3_Missense_Mutation_p.P832S|BRCA1_ENST00000591849.1_Intron|BRCA1_ENST00000591534.1_Intron|BRCA1_ENST00000352993.3_Intron|BRCA1_ENST00000491747.2_Intron|BRCA1_ENST00000586385.1_Intron|BRCA1_ENST00000357654.3_Missense_Mutation_p.P832S	NM_007297.3	NP_009228.2	P38398	BRCA1_HUMAN	breast cancer 1, early onset	832					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(30)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(28)|ovary(36)|skin(2)|stomach(4)|urinary_tract(2)	120		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TGTCCCAATGGATACTTAAAG	0.373000			"""D, Mis, N, F, S"""		ovarian	"""breast, ovarian"""		Homologous recombination	Hereditary Breast-Ovarian Cancer, BRCA1 type	TCGA Ovarian(2;0.000030)			48	68					0	0	1	0	0
PAIP2	51247	broad.mit.edu	37	5	138699534	138699534	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:138699534A>G	ENST00000394795.2	+	2	1052	c.61A>G	c.(61-63)Aac>Gac	p.N21D	PAIP2_ENST00000511706.1_Missense_Mutation_p.N21D|PAIP2_ENST00000510080.1_Missense_Mutation_p.N21D|PAIP2_ENST00000265192.4_Missense_Mutation_p.N21D			Q9BPZ3	PAIP2_HUMAN	poly(A) binding protein interacting protein 2	21					negative regulation of translational initiation	cytoplasm	protein binding|translation repressor activity			kidney(1)|large_intestine(2)|lung(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TGTGATTATTAACGGTCATTC	0.368000													13	13					0	0	1	0	0
PHACTR4	65979	broad.mit.edu	37	1	28793236	28793236	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:28793236C>T	ENST00000373839.3	+	6	1041	c.780C>T	c.(778-780)atC>atT	p.I260I	PHACTR4_ENST00000493669.1_3'UTR|PHACTR4_ENST00000373836.3_Silent_p.I270I	NM_001048183.1	NP_001041648.1	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4	260	Pro-rich.						actin binding|protein phosphatase inhibitor activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		AGCCCCCTATCCCTCCCCCTA	0.522000													28	46					0	0	1	0	0
A2M	2	broad.mit.edu	37	12	9260172	9260172	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:9260172G>A	ENST00000318602.7	-	8	1134	c.827C>T	c.(826-828)tCc>tTc	p.S276F		NM_000014.4	NP_000005.2	P01023	A2MG_HUMAN	alpha-2-macroglobulin	276					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	GTGGCAGTCGGAAGCGTCACT	0.438000													22	30					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85401339	85401339	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:85401339C>T	ENST00000258888.5	+	6	4143	c.3976C>T	c.(3976-3978)Cct>Tct	p.P1326S		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1326					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GCAGGCAGCCCCTGGACAGGG	0.677000													11	11					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	80773077	80773077	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:80773077G>A	ENST00000466387.1	+	15	2153	c.1429G>A	c.(1429-1431)Gtt>Att	p.V477I	CTNNA2_ENST00000540488.1_Missense_Mutation_p.V477I|CTNNA2_ENST00000361291.4_Missense_Mutation_p.V511I|CTNNA2_ENST00000541047.1_Missense_Mutation_p.V477I|CTNNA2_ENST00000496558.1_Missense_Mutation_p.V477I|CTNNA2_ENST00000402739.4_Missense_Mutation_p.V477I|CTNNA2_ENST00000343114.3_Missense_Mutation_p.V156I			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	477					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						ACAGAGCAAAGTTGCTCAGGA	0.507000													7	10					0	0	1	0	0
DCSTAMP	81501	broad.mit.edu	37	8	105361671	105361671	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:105361671C>T	ENST00000297581.2	+	2	940	c.891C>T	c.(889-891)ttC>ttT	p.F297F	DCSTAMP_ENST00000517991.1_Intron|DPYS_ENST00000521601.1_Intron	NM_030788.3	NP_110415.1	Q9H295	TM7S4_HUMAN	dendrocyte expressed seven transmembrane protein	297					osteoclast differentiation	cell surface|integral to membrane|plasma membrane											GGCTGTTTTTCCTCCCCATAC	0.478000													54	142					0	0	1	0	0
CP	1356	broad.mit.edu	37	3	148905923	148905923	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:148905923C>T	ENST00000264613.6	-	10	2042	c.1780G>A	c.(1780-1782)Gaa>Aaa	p.E594K	CP_ENST00000462336.1_5'UTR	NM_000096.3	NP_000087.1	P00450	CERU_HUMAN	ceruloplasmin (ferroxidase)	594	F5/8 type A 2.|Plastocyanin-like 4.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			breast(6)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	ATATTATCTTCCAGGAGTAAA	0.338000													27	30					0	0	1	0	0
JPH3	57338	broad.mit.edu	37	16	87717796	87717796	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr16:87717796G>A	ENST00000284262.2	+	3	1451	c.1209G>A	c.(1207-1209)caG>caA	p.Q403Q	JPH3_ENST00000563609.1_3'UTR	NM_020655.2	NP_065706.2	Q8WXH2	JPH3_HUMAN	junctophilin 3	403	Ala-rich.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(80;0.0287)		CAGCAGCTCAGAAAGCCCAGG	0.657000													9	6					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63447872	63447872	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:63447872C>T	ENST00000322893.7	-	6	928	c.660G>A	c.(658-660)gtG>gtA	p.V220V	KCNH5_ENST00000394964.2_Silent_p.V162V|KCNH5_ENST00000420622.2_Silent_p.V220V|KCNH5_ENST00000394968.1_Silent_p.V162V	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	220					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		GAATTAAAATCACCCAATCCC	0.393000													19	19					0	0	1	0	0
LINGO1	84894	broad.mit.edu	37	15	77907869	77907869	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:77907869C>A	ENST00000355300.6	-	2	554	c.380G>T	c.(379-381)cGc>cTc	p.R127L	LINGO1_ENST00000561030.1_Missense_Mutation_p.R121L	NM_032808.5	NP_116197.4	Q96FE5	LIGO1_HUMAN	leucine rich repeat and Ig domain containing 1	127					negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	31						GCGGTTGCTGCGGAGACCCAG	0.602000													14	14					1.5842e-08	1.60222e-08	1	1	0
FSIP2	401024	broad.mit.edu	37	2	186672707	186672707	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:186672707C>T	ENST00000343098.5	+	17	18941	c.18941C>T	c.(18940-18942)tCc>tTc	p.S6314F	FSIP2_ENST00000424728.1_Missense_Mutation_p.S6225F	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						GAATTTATCTCCAAAAGTAAG	0.308000													9	14					0	0	1	0	0
EPB41L2	2037	broad.mit.edu	37	6	131277451	131277451	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:131277451G>C	ENST00000337057.3	-	2	356	c.175C>G	c.(175-177)Cta>Gta	p.L59V	EPB41L2_ENST00000527659.1_Missense_Mutation_p.L59V|EPB41L2_ENST00000525193.1_Missense_Mutation_p.L59V|EPB41L2_ENST00000392427.3_Missense_Mutation_p.L59V|EPB41L2_ENST00000445890.2_Missense_Mutation_p.L59V|EPB41L2_ENST00000529208.1_Missense_Mutation_p.L59V|EPB41L2_ENST00000525271.1_Missense_Mutation_p.L59V|EPB41L2_ENST00000527411.1_Missense_Mutation_p.L59V|EPB41L2_ENST00000530481.1_Missense_Mutation_p.L59V|EPB41L2_ENST00000368128.2_Missense_Mutation_p.L59V|EPB41L2_ENST00000528282.1_Missense_Mutation_p.L59V|EPB41L2_ENST00000530148.1_Intron	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	59					cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		TGGCGGCGTAGACTACTTTGG	0.468000													30	56					0	0	1	0	0
TCP10	6953	broad.mit.edu	37	6	167787877	167787877	+	Missense_Mutation	SNP	C	C	T	rs140641521	by1000genomes	TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:167787877C>T	ENST00000366827.2	-	7	962	c.751G>A	c.(751-753)Gag>Aag	p.E251K	TCP10_ENST00000397829.4_Missense_Mutation_p.E251K			Q12799	TCP10_HUMAN	t-complex 10	278						cytosol				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(2)|lung(6)	18		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)|GBM - Glioblastoma multiforme(31;0.0386)		CTGGCGAACTCGTCAGCTTGA	0.542000													3	27					0	0	1	0	0
TFR2	7036	broad.mit.edu	37	7	100238723	100238723	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:100238723C>T	ENST00000462107.1	-	3	449	c.162G>A	c.(160-162)atG>atA	p.M54I	TFR2_ENST00000223051.3_Missense_Mutation_p.M54I|TFR2_ENST00000431692.1_Missense_Mutation_p.M54I			Q9UP52	TFR2_HUMAN	transferrin receptor 2	54					cellular iron ion homeostasis|iron ion transport|proteolysis	cytoplasm|integral to plasma membrane	peptidase activity|transferrin receptor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(1)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					CCCTCAGCTCCATGGGGCAGA	0.677000													5	11					0	0	1	0	0
FASN	2194	broad.mit.edu	37	17	80051581	80051581	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:80051581G>A	ENST00000306749.2	-	4	565	c.347C>T	c.(346-348)aCc>aTc	p.T116I		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	116	Beta-ketoacyl synthase (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	GGCCTCCGAGGTCTCAGAGCC	0.637000													31	74					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9045740	9045740	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:9045740G>A	ENST00000397910.4	-	5	36094	c.35891C>T	c.(35890-35892)cCa>cTa	p.P11964L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11966	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GATAGTGGTTGGACTCACTCC	0.478000													40	51					0	0	1	0	0
MALL	7851	broad.mit.edu	37	2	110849295	110849295	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:110849295G>A	ENST00000272462.2	-	2	931	c.158C>T	c.(157-159)cCc>cTc	p.P53L	MALL_ENST00000427178.1_Intron	NM_005434.4	NP_005425.1	Q13021	MALL_HUMAN	mal, T-cell differentiation protein-like	53	MARVEL.				cholesterol homeostasis	clathrin-coated vesicle|Golgi membrane|integral to membrane|membrane raft|plasma membrane	protein binding			kidney(1)|large_intestine(3)|lung(1)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	9				Epithelial(1;0.0546)|STAD - Stomach adenocarcinoma(1;0.18)		TTGCAGCAAGGGGTATACTAT	0.438000													9	49					0	0	1	0	0
HEXDC	284004	broad.mit.edu	37	17	80391593	80391593	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:80391593C>T	ENST00000337014.6	+	5	816	c.342C>T	c.(340-342)acC>acT	p.T114T	HEXDC_ENST00000327949.9_Silent_p.T114T|HEXDC_ENST00000577944.1_Silent_p.T114T	NM_173620.2	NP_775891.2	Q8WVB3	HEXDC_HUMAN	hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing	114					carbohydrate metabolic process	cytoplasm|nucleus	beta-N-acetylhexosaminidase activity|cation binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)	16	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			TCCCCTGCACCCTGAACCCCC	0.672000													16	76					0	0	1	0	0
PCDHGA11	56105	broad.mit.edu	37	5	140803044	140803044	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:140803044C>T	ENST00000398587.2	+	1	2283	c.2250C>T	c.(2248-2250)ttC>ttT	p.F750F	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018914.2|NM_032092.1	NP_061737.1|NP_114481.1														breast(3)|endometrium(8)|kidney(3)|large_intestine(9)|lung(22)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACAGGCTTTCCTGCAAACCT	0.577000													23	42					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21101739	21101739	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:21101739G>A	ENST00000377122.4	-	24	2873	c.2477C>T	c.(2476-2478)cCt>cTt	p.P826L	NEBL_ENST00000377159.4_Missense_Mutation_p.P129L|NEBL_ENST00000417816.2_Missense_Mutation_p.P163L	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	826					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						CACGATGTGAGGGTGGACCCC	0.547000													5	22					0	0	1	0	0
OR2G2	81470	broad.mit.edu	37	1	247752312	247752312	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:247752312C>T	ENST00000320065.1	+	1	651	c.651C>T	c.(649-651)atC>atT	p.I217I	RP11-978I15.10_ENST00000446347.1_RNA|RP11-978I15.10_ENST00000435333.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	217					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TCTCATTCATCCTGGTCTCCT	0.517000													15	34					0	0	1	0	0
PPA1	5464	broad.mit.edu	37	10	71973282	71973282	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:71973282C>T	ENST00000373232.2	-	6	547	c.448G>A	c.(448-450)Ggg>Agg	p.G150R	PPA1_ENST00000373230.4_Missense_Mutation_p.G150R	NM_021129.3	NP_066952.1	Q15181	IPYR_HUMAN	pyrophosphatase (inorganic) 1	150					diphosphate metabolic process|tRNA aminoacylation for protein translation	cytosol	inorganic diphosphatase activity|magnesium ion binding			breast(2)|endometrium(1)|large_intestine(2)|lung(3)|skin(2)	10						TCGGTTTCCCCTTCGTCAATC	0.388000													25	32					0	0	1	0	0
ELFN2	114794	broad.mit.edu	37	22	37769437	37769437	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr22:37769437G>A	ENST00000402918.1	-	3	2923	c.2138C>T	c.(2137-2139)cCc>cTc	p.P713L	ELFN2_ENST00000349653.3_Missense_Mutation_p.P713L|RP1-63G5.5_ENST00000430883.1_RNA	NM_052906.3	NP_443138.2	Q5R3F8	LRFN6_HUMAN	extracellular leucine-rich repeat and fibronectin type III domain containing 2	713						cell surface|integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	35	Melanoma(58;0.0574)					GTACAGGGCGGGAAAGCTGTG	0.711000													4	7					0	0	1	0	0
ADAMTS4	9507	broad.mit.edu	37	1	161163569	161163569	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:161163569G>C	ENST00000367996.4	-	6	2024	c.1596C>G	c.(1594-1596)tgC>tgG	p.C532W		NM_005099.4	NP_005090.3	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 4	532	TSP type-1.				proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(20)|ovary(4)|prostate(3)|skin(1)|urinary_tract(1)	43	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			AGGTCCGAGAGCAGTCACCCC	0.622000													17	39					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152185609	152185609	+	Silent	SNP	A	A	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:152185609A>G	ENST00000368801.2	-	3	8571	c.8496T>C	c.(8494-8496)ccT>ccC	p.P2832P	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	2832					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AAGTGCTACTAGGAAAACTGA	0.393000													12	30					0	0	1	0	0
SDF4	51150	broad.mit.edu	37	1	1163999	1163999	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:1163999G>A	ENST00000263741.7	-	2	467	c.175C>T	c.(175-177)Cca>Tca	p.P59S	SDF4_ENST00000545427.1_Missense_Mutation_p.P59S|SDF4_ENST00000360001.6_Missense_Mutation_p.P59S|SDF4_ENST00000459994.2_5'UTR	NM_016176.3|NM_016547.2	NP_057260.2|NP_057631.1	Q9BRK5	CAB45_HUMAN	stromal cell derived factor 4	59					cerebellum development|fat cell differentiation|response to ethanol|UV protection|zymogen granule exocytosis	bleb|Golgi lumen|late endosome|soluble fraction	calcium ion binding|identical protein binding|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;7.85e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.42e-21)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;4.83e-05)|Kidney(185;0.00252)|BRCA - Breast invasive adenocarcinoma(365;0.00263)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0368)|Lung(427;0.204)		AGGTGGTCTGGGGGCAGGATC	0.612000													23	34					0	0	1	0	0
SPATA21	374955	broad.mit.edu	37	1	16736390	16736390	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:16736390G>T	ENST00000335496.1	-	6	775	c.293C>A	c.(292-294)tCc>tAc	p.S98Y	SPATA21_ENST00000540400.1_Missense_Mutation_p.S75Y|SPATA21_ENST00000466212.1_5'UTR	NM_198546.1	NP_940948.1	Q7Z572	SPT21_HUMAN	spermatogenesis associated 21	98							calcium ion binding			breast(1)|endometrium(2)|lung(8)|ovary(2)|pancreas(3)|stomach(1)|urinary_tract(2)	19		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.15e-05)|BRCA - Breast invasive adenocarcinoma(304;4.2e-05)|Kidney(64;0.000183)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.0122)|READ - Rectum adenocarcinoma(331;0.0651)		TCTCCGATGGGAGGCCTCCAT	0.657000													14	24					9.04627e-18	9.25442e-18	1	1	0
FIZ1	84922	broad.mit.edu	37	19	56103979	56103979	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:56103979G>A	ENST00000221665.3	-	3	1417	c.1328C>T	c.(1327-1329)cCg>cTg	p.P443L		NM_032836.2	NP_116225.2	Q96SL8	FIZ1_HUMAN	FLT3-interacting zinc finger 1	443					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein kinase binding|receptor binding|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)	11			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		CTCCAGGCACGGGAACGGCTT	0.662000													17	16					0	0	1	0	0
ZNF638	27332	broad.mit.edu	37	2	71576558	71576558	+	Silent	SNP	T	T	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:71576558T>C	ENST00000409544.1	+	2	1104	c.474T>C	c.(472-474)agT>agC	p.S158S	ZNF638_ENST00000410075.1_3'UTR|ZNF638_ENST00000377802.2_Silent_p.S158S|ZNF638_ENST00000264447.4_Silent_p.S158S|ZNF638_ENST00000355812.3_Silent_p.S158S	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	158					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						AAGAACTTAGTCGCTATCCTG	0.398000													14	33					0	0	1	0	0
ZNF135	7694	broad.mit.edu	37	19	58578692	58578692	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:58578692C>T	ENST00000506786.1	+	5	1268	c.714C>T	c.(712-714)aaC>aaT	p.N238N	ZNF135_ENST00000511556.1_Silent_p.N292N|ZNF135_ENST00000359978.6_Silent_p.N292N|ZNF135_ENST00000439855.2_Silent_p.N280N|ZNF135_ENST00000401053.4_Silent_p.N304N|ZNF135_ENST00000313434.5_Silent_p.N280N			B4DHH9	B4DHH9_HUMAN	zinc finger protein 135	292					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(26)|ovary(1)|skin(1)|urinary_tract(1)	41		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		GGACCTTCAACCAAATTGCCC	0.493000													58	51					0	0	1	0	0
LAMC2	3918	broad.mit.edu	37	1	183191251	183191251	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:183191251G>A	ENST00000264144.4	+	6	733	c.668G>A	c.(667-669)cGa>cAa	p.R223Q	LAMC2_ENST00000493293.1_Missense_Mutation_p.R223Q	NM_005562.2	NP_005553.2	Q13753	LAMC2_HUMAN	laminin, gamma 2	223	Laminin IV type A.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			breast(2)|endometrium(6)|kidney(8)|large_intestine(11)|lung(18)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55						GCTGTCCAACGAAATGGGTCT	0.453000													19	31					0	0	1	0	0
GAS2L1	10634	broad.mit.edu	37	22	29708319	29708319	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr22:29708319C>T	ENST00000406549.3	+	6	1348	c.1198C>T	c.(1198-1200)Ccc>Tcc	p.P400S	GAS2L1_ENST00000407854.1_3'UTR|GAS2L1_ENST00000407647.2_3'UTR|GAS2L1_ENST00000403764.1_3'UTR|GAS2L1_ENST00000471961.1_3'UTR|GAS2L1_ENST00000360113.2_3'UTR			Q99501	GA2L1_HUMAN	growth arrest-specific 2 like 1	404					cell cycle arrest	cytoplasm|cytoskeleton				endometrium(2)|lung(2)|prostate(1)	5						TTGCACTGAACCCTCGAGGAC	0.697000													26	31					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108127150	108127150	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:108127150G>T	ENST00000273353.3	-	33	4713	c.4657C>A	c.(4657-4659)Cag>Aag	p.Q1553K		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1553						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						AGTGTCACCTGGACTTCTGTC	0.408000													45	73					1.0096e-33	1.03742e-33	1	1	0
LSG1	55341	broad.mit.edu	37	3	194387226	194387226	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:194387226T>C	ENST00000265245.5	-	3	616	c.302A>G	c.(301-303)aAg>aGg	p.K101R		NM_018385.2	NP_060855.2	Q9H089	LSG1_HUMAN	large 60S subunit nuclear export GTPase 1	101					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity			breast(2)|endometrium(3)|large_intestine(2)|lung(9)	16	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		ATGGAGCTTCTTAATTCTCTG	0.398000													26	37					0	0	1	0	0
INTS8	55656	broad.mit.edu	37	8	95869013	95869013	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:95869013C>T	ENST00000523731.1	+	15	1894	c.1761C>T	c.(1759-1761)tcC>tcT	p.S587S	INTS8_ENST00000520845.1_3'UTR|INTS8_ENST00000447247.1_Silent_p.S587S	NM_017864.2	NP_060334.2	Q75QN2	INT8_HUMAN	integrator complex subunit 8	587					snRNA processing	integrator complex	protein binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	28	Breast(36;1.05e-06)					AGGACTTTTCCCATGCTAAAC	0.428000													40	90					0	0	1	0	0
TCEB3C	162699	broad.mit.edu	37	18	44554593	44554593	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr18:44554593C>T	ENST00000330682.2	-	1	1856	c.1621G>A	c.(1621-1623)Gga>Aga	p.G541R	KATNAL2_ENST00000592005.1_Intron|KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000245121.5_Intron	NM_145653.3	NP_663628.2	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide 3C (elongin A3)	541					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding	p.G541R(1)		NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(16)|skin(2)	30						GAGAATCTTCCCTTGTAGTCT	0.577000													20	272					0	0	1	0	0
PMEPA1	56937	broad.mit.edu	37	20	56227485	56227485	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:56227485C>T	ENST00000341744.3	-	4	807	c.488G>A	c.(487-489)gGc>gAc	p.G163D	PMEPA1_ENST00000347215.4_Missense_Mutation_p.G128D|PMEPA1_ENST00000395814.1_Missense_Mutation_p.G113D|PMEPA1_ENST00000265626.4_Missense_Mutation_p.G113D|PMEPA1_ENST00000395816.3_Missense_Mutation_p.G113D	NM_020182.4	NP_064567.2	Q969W9	PMEPA_HUMAN	prostate transmembrane protein, androgen induced 1	163					androgen receptor signaling pathway	integral to membrane|plasma membrane	WW domain binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)	16						GGTGCAGGGGCCCTGGTAGGG	0.652000													19	12					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	33031450	33031450	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:33031450G>A	ENST00000340811.4	-	3	472	c.364C>T	c.(364-366)Cgc>Tgc	p.R122C	PKP2_ENST00000070846.6_Missense_Mutation_p.R122C	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2	122					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					CTTCCCCAGCGACCTTCATAA	0.478000													68	104					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176915132	176915132	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:176915132C>T	ENST00000367654.2	-	13	2216	c.2203G>A	c.(2203-2205)Gag>Aag	p.E735K	ASTN1_ENST00000424564.2_Missense_Mutation_p.E727K|ASTN1_ENST00000361833.2_Missense_Mutation_p.E727K|ASTN1_ENST00000281881.3_5'UTR|ASTN1_ENST00000367657.3_Missense_Mutation_p.E727K			O14525	ASTN1_HUMAN	astrotactin 1	735					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						AAGAACATCTCCCCAAAGAGG	0.498000													24	42					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101768645	101768645	+	Silent	SNP	T	T	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:101768645T>C	ENST00000261637.4	+	55	7365	c.7191T>C	c.(7189-7191)gtT>gtC	p.V2397V		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	2397					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						GTGAAGGAGTTGATTTTGAGA	0.368000													47	51					0	0	1	0	0
ZNF510	22869	broad.mit.edu	37	9	99521617	99521617	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:99521617G>A	ENST00000375231.1	-	6	2145	c.1495C>T	c.(1495-1497)Cag>Tag	p.Q499*	ZNF510_ENST00000223428.4_Nonsense_Mutation_p.Q499*			Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	499					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|stomach(1)|urinary_tract(1)	21		Acute lymphoblastic leukemia(62;0.0527)				GTGGACTTCTGAACAAAAGTT	0.413000													36	15					0	0	1	0	0
ZNF384	171017	broad.mit.edu	37	12	6776965	6776965	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:6776965G>A	ENST00000396795.1	-	9	1963	c.1466C>T	c.(1465-1467)cCg>cTg	p.P489L	ZNF384_ENST00000361959.3_Missense_Mutation_p.P550L|ZNF384_ENST00000355772.4_Missense_Mutation_p.P434L|ZNF384_ENST00000319770.3_Missense_Mutation_p.P473L|ZNF384_ENST00000396799.2_Missense_Mutation_p.P489L|ZNF384_ENST00000396801.3_Missense_Mutation_p.P550L|RP4-761J14.8_ENST00000589924.1_RNA			Q8TF68	ZN384_HUMAN	zinc finger protein 384	550	Ala-rich.|Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/ZNF384(4)	breast(3)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(1)	18						CGTCTTATACGGGGTCAGGTC	0.617000			T	"""EWSR1, TAF15 """	ALL								51	73					0	0	1	0	0
NCF1	653361	broad.mit.edu	37	7	74197916	74197916	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:74197916C>T	ENST00000289473.4	+	7	693	c.623C>T	c.(622-624)tCc>tTc	p.S208F	NCF1_ENST00000443956.3_3'UTR	NM_000265.4	NP_000256.3	P14598	NCF1_HUMAN	neutrophil cytosolic factor 1	208	SH3 1.				cell communication|cellular defense response|innate immune response|protein targeting to membrane|respiratory burst|superoxide anion generation	cytosol|NADPH oxidase complex|soluble fraction	electron carrier activity|GTP binding|GTPase activity|phosphatidylinositol binding|SH3 domain binding|superoxide-generating NADPH oxidase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|skin(3)	10						ATCCCAGCGTCCTTCCTCGAG	0.632000													9	30					0	0	1	0	0
FOXJ3	22887	broad.mit.edu	37	1	42744050	42744050	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:42744050G>A	ENST00000372572.1	-	5	649	c.338C>T	c.(337-339)cCa>cTa	p.P113L	FOXJ3_ENST00000372573.1_Missense_Mutation_p.P113L|FOXJ3_ENST00000361346.1_Missense_Mutation_p.P113L|FOXJ3_ENST00000545068.1_Missense_Mutation_p.P113L|FOXJ3_ENST00000361776.1_Missense_Mutation_p.P113L	NM_001198851.1	NP_001185780.1	Q9UPW0	FOXJ3_HUMAN	forkhead box J3	113					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	18	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TCTATAATATGGGAAGTTATC	0.318000													22	26					0	0	1	0	0
DHX29	54505	broad.mit.edu	37	5	54557288	54557288	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:54557288T>C	ENST00000251636.5	-	25	4016	c.3868A>G	c.(3868-3870)Ata>Gta	p.I1290V	RP11-506H20.1_ENST00000506435.1_RNA	NM_019030.2	NP_061903.2	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	1290							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|lung(6)|ovary(4)|prostate(1)|skin(3)|urinary_tract(2)	46		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				AAAGGGGTTATTAGGGTAGTT	0.363000													20	43					0	0	1	0	0
MATN4	8785	broad.mit.edu	37	20	43933431	43933431	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:43933431C>T	ENST00000537548.1	-	4	324	c.80G>A	c.(79-81)aGg>aAg	p.R27K	MATN4_ENST00000372753.1_Intron|MATN4_ENST00000372756.1_Missense_Mutation_p.R27K|MATN4_ENST00000353917.5_Missense_Mutation_p.R27K|MATN4_ENST00000372751.4_Intron|MATN4_ENST00000372754.1_Missense_Mutation_p.R27K|MATN4_ENST00000360607.5_Missense_Mutation_p.R27K|MATN4_ENST00000342716.4_Missense_Mutation_p.R27K			O95460	MATN4_HUMAN	matrilin 4	27						extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.0122)				AGTGTGACACCTGGGACCTGC	0.622000													10	8					0	0	1	0	0
PTPRH	5794	broad.mit.edu	37	19	55718307	55718307	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:55718307C>T	ENST00000376350.3	-	3	124	c.102G>A	c.(100-102)agG>agA	p.R34R	PTPRH_ENST00000588559.1_5'UTR|PTPRH_ENST00000263434.5_Silent_p.R34R	NM_002842.3	NP_002833.3	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	34	Fibronectin type-III 1.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(8)|lung(27)|ovary(2)|prostate(5)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	67		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		CTGTCAGGTTCCTCCCTGGGT	0.572000													27	17					0	0	1	0	0
RNF43	54894	broad.mit.edu	37	17	56434692	56434692	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:56434692G>A	ENST00000581868.1	-	8	2261	c.2064C>T	c.(2062-2064)aaC>aaT	p.N688N	RNF43_ENST00000577625.1_Intron|RNF43_ENST00000577716.1_Intron|RNF43_ENST00000500597.2_Intron|RNF43_ENST00000583753.1_Intron|BZRAP1-AS1_ENST00000583841.1_RNA|RNF43_ENST00000407977.2_Intron|RNF43_ENST00000584437.1_Intron			Q68DV7	RNF43_HUMAN	ring finger protein 43	0	Pro-rich.					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			NS(1)|biliary_tract(5)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(14)|lung(9)|ovary(2)|pancreas(10)|prostate(1)|skin(4)	60	Medulloblastoma(34;0.127)|all_neural(34;0.237)					tgtcccgatggttaagtattt	0.517000													3	5					0	0	1	0	0
PARP12	64761	broad.mit.edu	37	7	139726008	139726008	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:139726008G>A	ENST00000263549.3	-	11	2642	c.1769C>T	c.(1768-1770)tCc>tTc	p.S590F		NM_022750.2	NP_073587.1	Q9H0J9	PAR12_HUMAN	poly (ADP-ribose) polymerase family, member 12	590	PARP catalytic.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(1)	19	Melanoma(164;0.0142)					CTTGCCGTAGGAAGTGCCATG	0.587000													19	46					0	0	1	0	0
SLC1A6	6511	broad.mit.edu	37	19	15063832	15063832	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:15063832G>A	ENST00000430939.2	-	8	1344	c.1215C>T	c.(1213-1215)ccC>ccT	p.P405P	SLC1A6_ENST00000600144.1_Silent_p.P391P|SLC1A6_ENST00000221742.3_Silent_p.P469P			P48664	EAA4_HUMAN	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	469					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(8)|liver(1)|lung(12)|ovary(3)|pancreas(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42					L-Glutamic Acid(DB00142)	GACCCGCCTGGGGGATGCCAG	0.607000													72	117					0	0	1	0	0
KANSL1	284058	broad.mit.edu	37	17	44248953	44248953	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:44248953G>A	ENST00000262419.6	-	2	1027	c.557C>T	c.(556-558)tCt>tTt	p.S186F	KANSL1_ENST00000575318.1_Missense_Mutation_p.S186F|KANSL1_ENST00000574590.1_Missense_Mutation_p.S186F|KANSL1_ENST00000572904.1_Missense_Mutation_p.S186F|KANSL1_ENST00000393476.3_5'UTR|KANSL1_ENST00000432791.1_Missense_Mutation_p.S186F	NM_001193466.1	NP_001180395.1	Q7Z3B3	K1267_HUMAN	KAT8 regulatory NSL complex subunit 1	186						MLL1 complex	protein binding										ATGAAGAGCAGATGAAGTGAG	0.458000													34	98					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126173490	126173490	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:126173490G>A	ENST00000339582.2	-	9	2754	c.1946C>T	c.(1945-1947)tCc>tTc	p.S649F	GRM8_ENST00000358373.3_Missense_Mutation_p.S649F|GRM8_ENST00000480995.1_5'UTR|GRM8_ENST00000444921.2_Missense_Mutation_p.S649F			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	649					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane		p.S649F(1)		breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CCGTCGGAAGGAGCATATGAT	0.453000										HNSCC(24;0.065)			9	41					0	0	1	0	0
PANX3	116337	broad.mit.edu	37	11	124481634	124481634	+	Splice_Site	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:124481634G>A	ENST00000284288.2	+	1	248		c.e1+1			NM_052959.2	NP_443191.1	Q96QZ0	PANX3_HUMAN	pannexin 3						protein hexamerization	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(10)|prostate(2)|skin(2)|urinary_tract(1)	26	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0219)		TTCTCCTCTGGTAAGTTGCTT	0.577000													12	17					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38888431	38888431	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:38888431C>T	ENST00000302328.3	-	26	5328	c.5130G>A	c.(5128-5130)aaG>aaA	p.K1710K	SCN11A_ENST00000450244.1_Silent_p.K1710K|SCN11A_ENST00000456224.3_Silent_p.K1672K	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1710					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CTTCCATGAACTTCTCTTCCA	0.463000													50	67					0	0	1	0	0
PRTG	283659	broad.mit.edu	37	15	55965624	55965624	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:55965624C>T	ENST00000389286.4	-	10	1844	c.1797G>A	c.(1795-1797)ctG>ctA	p.L599L		NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	599	Fibronectin type-III 2.				multicellular organismal development	integral to membrane				breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		ATGACTCTCCCAGCCCCACTC	0.478000													16	32					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6966275	6966275	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr18:6966275G>A	ENST00000389658.3	-	49	7014	c.6921C>T	c.(6919-6921)tcC>tcT	p.S2307S		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	2307	Laminin G-like 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAAAATGGAAGGAAGGGTCTT	0.453000													3	3					0	0	1	0	0
GABRA1	2554	broad.mit.edu	37	5	161324256	161324256	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:161324256T>A	ENST00000428797.2	+	11	1554	c.1199T>A	c.(1198-1200)gTc>gAc	p.V400D	GABRA1_ENST00000023897.6_Missense_Mutation_p.V400D|GABRA1_ENST00000444819.1_Missense_Mutation_p.V400D|GABRA1_ENST00000420560.1_Missense_Mutation_p.V400D|GABRA1_ENST00000393943.4_Missense_Mutation_p.V400D|GABRA1_ENST00000437025.2_Missense_Mutation_p.V400D	NM_001127643.1	NP_001121115.1	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 1	400					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(4)|liver(1)|lung(22)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(1)	42	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	CCTAAAGAGGTCAAGCCCGAA	0.488000													6	66					0	0	1	0	0
C9	735	broad.mit.edu	37	5	39306815	39306815	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:39306815C>T	ENST00000263408.4	-	9	1415	c.1320G>A	c.(1318-1320)ctG>ctA	p.L440L		NM_001737.3	NP_001728.1	P02748	CO9_HUMAN	complement component 9	440	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex				central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			GCTTTTCTTTCAGTTCAAATG	0.393000													13	28					0	0	1	0	0
JMJD7-PLA2G4B	8681	broad.mit.edu	37	15	42129313	42129313	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:42129313C>T	ENST00000542534.1	+	8	950	c.910C>T	c.(910-912)Cag>Tag	p.Q304*	JMJD7_ENST00000408047.1_Nonsense_Mutation_p.Q205*|JMJD7-PLA2G4B_ENST00000382448.4_Intron|JMJD7-PLA2G4B_ENST00000476036.1_Intron|JMJD7-PLA2G4B_ENST00000342159.4_Intron|JMJD7_ENST00000397299.4_Nonsense_Mutation_p.Q304*	NM_001114632.1	NP_001108104.1	P0C869	PA24B_HUMAN		0	PLA2c.				arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			endometrium(3)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(3)|skin(1)|soft_tissue(1)|urinary_tract(2)	25						TAGTTACTTCCAGCTGCTCGA	0.557000													15	6					0	0	1	0	0
AK9	221264	broad.mit.edu	37	6	109819134	109819134	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:109819134G>A	ENST00000424296.2	-	37	5157	c.5081C>T	c.(5080-5082)cCc>cTc	p.P1694L	RP5-919F19.5_ENST00000423747.1_RNA	NM_001145128.2	NP_001138600.2			adenylate kinase 9																		AGGTGCTAAGGGAGGCACGTA	0.463000													16	23					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117171125	117171125	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:117171125G>A	ENST00000003084.6	+	4	578	c.446G>A	c.(445-447)gGa>gAa	p.G149E	CFTR_ENST00000454343.1_Missense_Mutation_p.G149E	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	149	ABC transmembrane type-1 1.		G -> R (in CBAVD).		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	CATCACATTGGAATGCAGATG	0.408000									Cystic Fibrosis				4	17					0	0	1	0	0
CAMLG	819	broad.mit.edu	37	5	134079737	134079737	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:134079737C>T	ENST00000297156.2	+	3	814	c.694C>T	c.(694-696)Ccc>Tcc	p.P232S	CAMLG_ENST00000514518.1_Missense_Mutation_p.S78F	NM_001745.3	NP_001736.1	P49069	CAMLG_HUMAN	calcium modulating ligand	232					defense response	endoplasmic reticulum|integral to membrane				NS(1)|cervix(1)|kidney(3)|lung(3)|prostate(1)	9			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Cyclosporine(DB00091)	CAAATATTTTCCCAAGGTAAA	0.289000													9	5					0	0	1	0	0
VPS37B	79720	broad.mit.edu	37	12	123351773	123351773	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:123351773G>A	ENST00000267202.2	-	4	1129	c.748C>T	c.(748-750)Ccc>Tcc	p.P250S		NM_024667.2	NP_078943.1	Q9H9H4	VP37B_HUMAN	vacuolar protein sorting 37 homolog B (S. cerevisiae)	250	Pro-rich.				cellular membrane organization|endosome transport|protein transport	late endosome membrane				breast(1)|central_nervous_system(1)|large_intestine(1)|skin(1)|urinary_tract(1)	5	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.08e-05)|Epithelial(86;0.000197)|BRCA - Breast invasive adenocarcinoma(302;0.205)		TGCTGAGTGGGGAGGCCCACG	0.667000													13	7					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8722110	8722110	+	Splice_Site	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:8722110G>A	ENST00000378641.3	+	23	2888		c.e23-1		PLCB1_ENST00000494924.1_Splice_Site|PLCB1_ENST00000378637.2_Splice_Site|PLCB1_ENST00000338037.6_Splice_Site	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)						activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						TCCCTATTTAGATGTCATCGA	0.388000													8	11					0	0	1	0	0
IKBKB	3551	broad.mit.edu	37	8	42176187	42176187	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:42176187C>T	ENST00000520810.1	+	13	1544	c.1358C>T	c.(1357-1359)gCc>gTc	p.A453V	IKBKB_ENST00000416505.2_Missense_Mutation_p.A394V|IKBKB_ENST00000379708.3_Missense_Mutation_p.A230V|IKBKB_ENST00000520835.1_Missense_Mutation_p.A451V|IKBKB_ENST00000522785.1_3'UTR|IKBKB_ENST00000522147.1_Intron	NM_001556.2	NP_001547.1	O14920	IKKB_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	453					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(4)|lung(1)|ovary(2)|skin(1)	8	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	GGACAGCGAGCCGCCATGTAG	0.537000													17	13					0	0	1	0	0
NCKIPSD	51517	broad.mit.edu	37	3	48716841	48716841	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:48716841G>A	ENST00000294129.2	-	9	1658	c.1539C>T	c.(1537-1539)tcC>tcT	p.S513S	NCKIPSD_ENST00000341520.4_Silent_p.S513S|NCKIPSD_ENST00000416649.2_Silent_p.S506S	NM_016453.2	NP_057537.1	Q9NZQ3	SPN90_HUMAN	NCK interacting protein with SH3 domain	513					cytoskeleton organization|NLS-bearing substrate import into nucleus|signal transduction	intermediate filament|nucleus	cytoskeletal protein binding|SH3 domain binding			endometrium(1)|large_intestine(3)|lung(6)|prostate(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CCTCTCCCATGGAGAAGACCA	0.582000													23	30					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159687209	159687209	+	Missense_Mutation	SNP	G	G	A	rs143447403	by1000genomes	TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:159687209G>A	ENST00000297267.9	+	21	5578	c.5378G>A	c.(5377-5379)cGa>cAa	p.R1793Q	FNDC1_ENST00000340366.6_Missense_Mutation_p.R1730Q	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1793						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		ACGTGGTATCGAAAGTTCGTG	0.478000													20	27					0	0	1	0	0
GP5	2814	broad.mit.edu	37	3	194118880	194118880	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:194118880G>A	ENST00000401815.1	-	1	203	c.132C>T	c.(130-132)tcC>tcT	p.S44S	GP5_ENST00000323007.3_Silent_p.S44S			P40197	GPV_HUMAN	glycoprotein V (platelet)	44	LRRNT.				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane				breast(3)|central_nervous_system(2)|endometrium(2)|large_intestine(9)|lung(14)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	35	all_cancers(143;6.64e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;7.38e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.06e-05)		GGCCTAGCGCGGAGATGCGCG	0.697000													22	24					0	0	1	0	0
FUT8	2530	broad.mit.edu	37	14	66200042	66200042	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:66200042C>T	ENST00000360689.5	+	10	3080	c.1353C>T	c.(1351-1353)atC>atT	p.I451I	FUT8_ENST00000394586.2_Silent_p.I451I|FUT8_ENST00000358307.2_Silent_p.I322I|FUT8_ENST00000394585.1_Silent_p.I451I|FUT8_ENST00000417683.1_Silent_p.I45I|FUT8_ENST00000557164.1_Silent_p.I288I	NM_004480.4|NM_178155.2	NP_004471.4|NP_835368.1	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 (alpha (1,6) fucosyltransferase)	451					in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	22				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		GTGGAGTGATCCTGGATATAC	0.383000													23	33					0	0	1	0	0
CR2	1380	broad.mit.edu	37	1	207642047	207642047	+	Silent	SNP	C	C	T	rs140138320		TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:207642047C>T	ENST00000367057.3	+	3	810	c.621C>T	c.(619-621)ccC>ccT	p.P207P	CR2_ENST00000485707.1_3'UTR|CR2_ENST00000367058.3_Silent_p.P207P|CR2_ENST00000367059.3_Silent_p.P207P|CR2_ENST00000458541.2_Silent_p.P207P	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	207	Sushi 3.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						GTGCTGTCCCCCCCACATGTG	0.403000													44	57					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51870675	51870675	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:51870675C>T	ENST00000371497.5	+	2	1565	c.678C>T	c.(676-678)acC>acT	p.T226T	TSHZ2_ENST00000329613.6_Silent_p.T223T|TSHZ2_ENST00000603338.2_Silent_p.T223T	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	226					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			CCTATGACACCCTAGTCGAGC	0.557000													16	14					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140229437	140229437	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:140229437C>T	ENST00000378122.3	+	1	2081	c.1357C>T	c.(1357-1359)Cca>Tca	p.P453S	PCDHA4_ENST00000512229.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA9_ENST00000532602.1_Missense_Mutation_p.P453S|PCDHA4_ENST00000530339.1_Intron|PCDHA8_ENST00000531613.1_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGACAACGCACCAGCGTTCGC	0.672000													38	64					0	0	1	0	0
MIR1283-1	100302265	broad.mit.edu	37	19	54191796	54191796	+	RNA	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:54191796C>T	ENST00000408494.1	+	0	62					NR_031573.1																						GAAAGCGCTTCCCTTTTGAGG	0.428000													36	23					0	0	1	0	0
HMGCLL1	54511	broad.mit.edu	37	6	55300472	55300472	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:55300472G>A	ENST00000398661.2	-	10	1232	c.1101C>T	c.(1099-1101)tcC>tcT	p.S367S	HMGCLL1_ENST00000274901.4_Silent_p.S337S|HMGCLL1_ENST00000370850.2_Silent_p.S234S|HMGCLL1_ENST00000507223.1_5'UTR|HMGCLL1_ENST00000308161.4_Silent_p.S305S|HMGCLL1_ENST00000508459.1_Silent_p.S171S	NM_019036.2	NP_061909.2	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1	367							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	31	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			AAGCATTGAAGGAGGCTTGTG	0.383000													20	20					0	0	1	0	0
GSTCD	79807	broad.mit.edu	37	4	106638778	106638778	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:106638778C>T	ENST00000515279.1	+	2	228	c.8C>T	c.(7-9)gCc>gTc	p.A3V	GSTCD_ENST00000507281.1_Missense_Mutation_p.A3V|GSTCD_ENST00000515255.1_Intron|GSTCD_ENST00000394728.3_Missense_Mutation_p.A3V|GSTCD_ENST00000394730.3_Missense_Mutation_p.A3V|GSTCD_ENST00000360505.5_Missense_Mutation_p.A3V			Q8NEC7	GSTCD_HUMAN	glutathione S-transferase, C-terminal domain containing	3						cytoplasm	rRNA methyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(2)|ovary(1)|skin(1)	14		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.15e-07)|READ - Rectum adenocarcinoma(30;0.139)		AAAATGAAAGCCATAAAGAAA	0.308000													8	18					0	0	1	0	0
ITGA2B	3674	broad.mit.edu	37	17	42452071	42452071	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:42452071G>A	ENST00000262407.5	-	28	2930	c.2899C>T	c.(2899-2901)Ccc>Tcc	p.P967S	ITGA2B_ENST00000353281.4_Intron	NM_000419.3	NP_000410.2	P08514	ITA2B_HUMAN	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	967					axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			biliary_tract(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	ACCGCATAGGGGAGGGAGGAC	0.622000													21	19					0	0	1	0	0
ZNF850	342892	broad.mit.edu	37	19	37240154	37240154	+	Silent	SNP	T	T	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:37240154T>C	ENST00000591344.1	-	5	1946	c.1788A>G	c.(1786-1788)aaA>aaG	p.K596K	ZNF850_ENST00000589390.1_Intron	NM_001193552.1|NM_001267779.1	NP_001180481.1|NP_001254708.1	A8MQ14	ZN850_HUMAN	zinc finger protein 850	596					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding										CAGTAAAAGATTTTCCACATT	0.393000													8	1					0	0	1	0	0
PTPRG	5793	broad.mit.edu	37	3	62257194	62257194	+	Missense_Mutation	SNP	G	G	A	rs150212631		TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:62257194G>A	ENST00000474889.1	+	21	3523	c.3146G>A	c.(3145-3147)cGg>cAg	p.R1049Q	PTPRG-AS1_ENST00000474795.1_RNA|PTPRG-AS1_ENST00000475371.1_RNA|PTPRG-AS1_ENST00000479018.1_RNA|PTPRG-AS1_ENST00000462497.1_RNA|PTPRG-AS1_ENST00000495542.1_RNA|PTPRG_ENST00000295874.10_Missense_Mutation_p.R1020Q	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	1049	Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		TCAGCAGCTCGGATGCCAGAA	0.537000													12	25					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141242965	141242965	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:141242965G>A	ENST00000389484.3	-	59	10343	c.9372C>T	c.(9370-9372)ctC>ctT	p.L3124L		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3124					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTTTGCTAACGAGTATAGTAG	0.368000										TSP Lung(27;0.18)			12	19					0	0	1	0	0
SEC24D	9871	broad.mit.edu	37	4	119745861	119745861	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:119745861C>T	ENST00000379735.5	-	3	433	c.162G>A	c.(160-162)agG>agA	p.R54R	SEC24D_ENST00000280551.6_Silent_p.R54R|SEC24D_ENST00000419654.2_5'UTR	NM_014822.2	NP_055637.2	O94855	SC24D_HUMAN	SEC24 family member D	54	Pro-rich.				COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(13)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	37						GCAACATTCCCCTAGTGGCGG	0.547000													28	49					0	0	1	0	0
G6PC	2538	broad.mit.edu	37	17	41055967	41055967	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:41055967C>T	ENST00000253801.2	+	2	329	c.250C>T	c.(250-252)Cca>Tca	p.P84S	G6PC_ENST00000592383.1_Missense_Mutation_p.P84S|G6PC_ENST00000585489.1_Missense_Mutation_p.P84S	NM_000151.3	NP_000142.2	P35575	G6PC_HUMAN	glucose-6-phosphatase, catalytic subunit	84					gluconeogenesis|glucose homeostasis|transmembrane transport	integral to endoplasmic reticulum membrane	glucose-6-phosphatase activity|phosphate binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)	23		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.113)		TGGACAGCGTCCATACTGGTG	0.473000													36	34					0	0	1	0	0
MAG	4099	broad.mit.edu	37	19	35791163	35791163	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:35791163G>A	ENST00000361922.4	+	6	976	c.826G>A	c.(826-828)Gac>Aac	p.D276N	MAG_ENST00000392213.3_Missense_Mutation_p.D276N|MAG_ENST00000537831.2_Missense_Mutation_p.D251N	NM_080600.2	NP_542167.1	P20916	MAG_HUMAN	myelin associated glycoprotein	276	Ig-like C2-type 2.				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(11)|skin(2)|upper_aerodigestive_tract(2)	34	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CTGGATGCGGGACGGGACAGT	0.687000													4	13					0	0	1	0	0
TP53BP1	7158	broad.mit.edu	37	15	43748792	43748792	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:43748792T>A	ENST00000263801.3	-	12	2251	c.1999A>T	c.(1999-2001)Atc>Ttc	p.I667F	TP53BP1_ENST00000450115.2_Missense_Mutation_p.I672F|TP53BP1_ENST00000382039.3_Missense_Mutation_p.I672F|TP53BP1_ENST00000382044.4_Missense_Mutation_p.I672F	NM_005657.2	NP_005648.1	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1	667					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			breast(4)|endometrium(5)|kidney(7)|large_intestine(22)|lung(13)|ovary(4)|pancreas(2)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(3)	72		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		GTCTCAGGGATTTCTTCCACC	0.463000								Other conserved DNA damage response genes					52	50					0	0	1	0	0
BAI1	575	broad.mit.edu	37	8	143559695	143559695	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:143559695G>A	ENST00000517894.1	+	7	2429	c.1535G>A	c.(1534-1536)cGa>cAa	p.R512Q	BAI1_ENST00000323289.5_Missense_Mutation_p.R512Q			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	512	TSP type-1 4.				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GTGGAGACCCGAGACTGCTTC	0.692000													7	13					0	0	1	0	0
ZNF432	9668	broad.mit.edu	37	19	52537279	52537279	+	Silent	SNP	G	G	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:52537279G>T	ENST00000594154.1	-	5	1865	c.1653C>A	c.(1651-1653)acC>acA	p.T551T	ZNF432_ENST00000221315.5_Silent_p.T551T			O94892	ZN432_HUMAN	zinc finger protein 432	551					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	29		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.0054)|OV - Ovarian serous cystadenocarcinoma(262;0.0182)		AGCGTTTCATGGTGAAGCCTT	0.408000													27	56					2.41591e-17	2.46931e-17	1	1	0
MYCT1	80177	broad.mit.edu	37	6	153042967	153042967	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:153042967G>A	ENST00000367245.5	+	2	295	c.287G>A	c.(286-288)aGa>aAa	p.R96K	MYCT1_ENST00000529453.1_Intron	NM_025107.2	NP_079383.2	Q8N699	MYCT1_HUMAN	myc target 1	96						nucleus				NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	20		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		CTGTCTCGAAGAAGAAGAGCC	0.478000													20	41					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78380729	78380729	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:78380729C>T	ENST00000278550.7	-	32	7123	c.6661G>A	c.(6661-6663)Ggg>Agg	p.G2221R		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		TGCAGGTTCCCATTGAGGTCG	0.552000													36	54					0	0	1	0	0
AFF3	3899	broad.mit.edu	37	2	100170904	100170904	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:100170904G>A	ENST00000317233.4	-	23	3663	c.3428C>T	c.(3427-3429)tCc>tTc	p.S1143F	AFF3_ENST00000356421.2_Missense_Mutation_p.S1168F|AFF3_ENST00000409236.1_Missense_Mutation_p.S1143F|AFF3_ENST00000409579.1_Missense_Mutation_p.S1168F	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	1143					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						GGTCGACGGGGACAGGGCGCT	0.647000													24	35					0	0	1	0	0
KHDRBS1	10657	broad.mit.edu	37	1	32498826	32498826	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:32498826C>T	ENST00000327300.7	+	4	829	c.662C>T	c.(661-663)gCc>gTc	p.A221V	KHDRBS1_ENST00000492989.1_Missense_Mutation_p.A182V|KHDRBS1_ENST00000307714.8_3'UTR	NM_006559.1	NP_006550.1	Q07666	KHDR1_HUMAN	KH domain containing, RNA binding, signal transduction associated 1	221					cell cycle arrest|cell proliferation|cell surface receptor linked signaling pathway|G2/M transition of mitotic cell cycle|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of RNA export from nucleus|transcription, DNA-dependent	membrane|nucleus	DNA binding|RNA binding|SH3 domain binding|SH3/SH2 adaptor activity			endometrium(4)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)	14		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				CCCAAATATGCCCACTTGAAT	0.463000													12	20					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110455984	110455984	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:110455984C>T	ENST00000378402.5	+	37	4748	c.4644C>T	c.(4642-4644)acC>acT	p.T1548T		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1548					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TGAACAATACCAGGGTTAAAA	0.428000										HNSCC(38;0.096)			5	35					0	0	1	0	0
TCP11	6954	broad.mit.edu	37	6	35087097	35087097	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:35087097C>T	ENST00000311875.5	-	9	1643	c.1226G>A	c.(1225-1227)gGc>gAc	p.G409D	TCP11_ENST00000412155.2_Missense_Mutation_p.G358D|TCP11_ENST00000244645.3_Missense_Mutation_p.G334D|TCP11_ENST00000444780.2_Missense_Mutation_p.G404D|TCP11_ENST00000418521.2_Missense_Mutation_p.G333D|TCP11_ENST00000373974.4_Missense_Mutation_p.G363D|TCP11_ENST00000373979.2_Missense_Mutation_p.G334D|TCP11_ENST00000512012.1_Missense_Mutation_p.G396D			Q8WWU5	TCP11_HUMAN	t-complex 11, testis-specific	396					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|kidney(5)|large_intestine(3)|lung(10)|ovary(3)|prostate(1)|skin(4)	27						AGCAACAAGGCCCATATTCTT	0.448000													34	46					0	0	1	0	0
PSME4	23198	broad.mit.edu	37	2	54164541	54164541	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:54164541G>A	ENST00000404125.1	-	5	737	c.682C>T	c.(682-684)Cat>Tat	p.H228Y	PSME4_ENST00000421748.2_Intron	NM_014614.2	NP_055429.2	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator subunit 4	228					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			breast(5)|endometrium(8)|kidney(1)|large_intestine(11)|lung(26)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(2)	60			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			AAACCTTTATGATGAAGTTCT	0.323000													15	11					0	0	1	0	0
FHDC1	85462	broad.mit.edu	37	4	153896837	153896837	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:153896837G>A	ENST00000511601.1	+	12	2582	c.2394G>A	c.(2392-2394)ccG>ccA	p.P798P	FHDC1_ENST00000260008.3_Silent_p.P798P			Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	798					actin cytoskeleton organization		actin binding		ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					GCGGGGACCCGGAGGAAGGCG	0.627000													29	38					0	0	1	0	0
VAV1	7409	broad.mit.edu	37	19	6828466	6828466	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:6828466G>A	ENST00000304076.2	+	11	1154	c.1060G>A	c.(1060-1062)Gag>Aag	p.E354K	VAV1_ENST00000602142.1_Missense_Mutation_p.E354K|VAV1_ENST00000599806.1_Missense_Mutation_p.E299K|VAV1_ENST00000596764.1_Missense_Mutation_p.E322K|VAV1_ENST00000539284.1_Missense_Mutation_p.E257K	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	354	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						GATGGAGAAGGAGAACCTGCG	0.627000													33	49					0	0	1	0	0
TDRD9	122402	broad.mit.edu	37	14	104490940	104490940	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:104490940C>T	ENST00000409874.4	+	25	2689	c.2641C>T	c.(2641-2643)Cct>Tct	p.P881S	TDRD9_ENST00000339063.5_Missense_Mutation_p.P881S	NM_153046.2	NP_694591.2	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	881					cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				GACGGTAGATCCTATGCAAGT	0.353000													14	42					0	0	1	0	0
EMCN	51705	broad.mit.edu	37	4	101344505	101344505	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:101344505G>A	ENST00000296420.4	-	6	650	c.472C>T	c.(472-474)Cca>Tca	p.P158S	EMCN_ENST00000305864.3_Intron|EMCN_ENST00000511970.1_Missense_Mutation_p.P145S	NM_001159694.1|NM_016242.3	NP_001153166.1|NP_057326.2	Q9ULC0	MUCEN_HUMAN	endomucin	158						extracellular region|integral to membrane|plasma membrane				endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(123;2.49e-08)		ATTGTAACTGGTATTGAGGTT	0.403000													18	17					0	0	1	0	0
DHCR7	1717	broad.mit.edu	37	11	71149970	71149970	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:71149970G>A	ENST00000355527.3	-	7	1062	c.786C>T	c.(784-786)ctC>ctT	p.L262L	DHCR7_ENST00000407721.2_Silent_p.L262L	NM_001163817.1|NM_001360.2	NP_001157289.1|NP_001351.2	Q9UBM7	DHCR7_HUMAN	7-dehydrocholesterol reductase	262					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|nuclear outer membrane	7-dehydrocholesterol reductase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(1)|skin(1)	19					NADH(DB00157)	CATGGCTGTGGAGCTCCCGCT	0.612000									Smith-Lemli-Opitz syndrome				13	23					0	0	1	0	0
S100A8	6279	broad.mit.edu	37	1	153362614	153362614	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:153362614G>A	ENST00000368733.3	-	3	416	c.247C>T	c.(247-249)Cac>Tac	p.H83Y	S100A8_ENST00000368732.1_Missense_Mutation_p.H83Y	NM_002964.4	NP_002955.2	P05109	S10A8_HUMAN	S100 calcium binding protein A8	83				VAAHKKSHEESHKE -> WQPTKKAMKKATKSS (in Ref. 1; CAA68390).	chemotaxis	cytoplasm|cytoskeleton|plasma membrane	calcium ion binding|protein binding			breast(1)|endometrium(1)|lung(1)|urinary_tract(1)	4	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			CTTTTTTTGTGGGCTGCCACG	0.483000													37	48					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33335742	33335742	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:33335742G>A	ENST00000404816.2	+	4	1310	c.957G>A	c.(955-957)ggG>ggA	p.G319G	LTBP1_ENST00000354476.3_Silent_p.G319G			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	319					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CCCAGAAGGGGATTTCAGGAG	0.488000													24	37					0	0	1	0	0
POLR2B	5431	broad.mit.edu	37	4	57883232	57883232	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:57883232G>A	ENST00000381227.1	+	16	2392	c.1979G>A	c.(1978-1980)gGg>gAg	p.G660E	POLR2B_ENST00000431623.2_Missense_Mutation_p.G585E|POLR2B_ENST00000441246.2_Missense_Mutation_p.G653E|POLR2B_ENST00000314595.5_Missense_Mutation_p.G660E			P30876	RPB2_HUMAN	polymerase (RNA) II (DNA directed) polypeptide B, 140kDa	660					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(10)|large_intestine(9)|lung(17)|ovary(2)|prostate(4)|skin(1)	52	Glioma(25;0.08)|all_neural(26;0.181)					GTGGCCAGTGGGGTAGTGGAG	0.368000													13	27					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181702138	181702138	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:181702138G>A	ENST00000526775.1	+	19	3024	c.2859G>A	c.(2857-2859)acG>acA	p.T953T	CACNA1E_ENST00000357570.5_Silent_p.T923T|CACNA1E_ENST00000367567.4_Silent_p.T579T|CACNA1E_ENST00000367570.1_Silent_p.T972T|CACNA1E_ENST00000367573.2_Silent_p.T972T|CACNA1E_ENST00000360108.3_Silent_p.T953T|CACNA1E_ENST00000358338.5_Silent_p.T904T	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	972					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity	p.T972T(2)		NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						AGGAGCCAACGATCCAAGAAG	0.562000													13	17					0	0	1	0	0
DHRS4	10901	broad.mit.edu	37	14	24435491	24435491	+	Splice_Site	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:24435491G>A	ENST00000313250.5	+	6	734		c.e6-1		DHRS4_ENST00000382761.3_Intron|DHRS4_ENST00000308178.8_Intron|DHRS4_ENST00000397073.2_Intron|DHRS4_ENST00000421831.1_Splice_Site|DHRS4_ENST00000558263.1_Intron|DHRS4_ENST00000397075.3_Intron|DHRS4_ENST00000558581.1_Splice_Site|DHRS4_ENST00000543741.2_Intron|DHRS4_ENST00000397074.3_Intron|DHRS4_ENST00000559632.1_Intron	NM_021004.2	NP_066284.2	Q9BTZ2	DHRS4_HUMAN	dehydrogenase/reductase (SDR family) member 4							mitochondrion|nuclear membrane|peroxisome	binding|carbonyl reductase (NADPH) activity			central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14				GBM - Glioblastoma multiforme(265;0.00962)	Vitamin A(DB00162)	TCTTTCTCCAGGGCTTCAGTC	0.478000													20	47					0	0	1	0	0
COL28A1	340267	broad.mit.edu	37	7	7483232	7483232	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:7483232C>T	ENST00000399429.3	-	20	1774	c.1634G>A	c.(1633-1635)gGa>gAa	p.G545E		NM_001037763.2	NP_001032852.2	Q2UY09	COSA1_HUMAN	collagen, type XXVIII, alpha 1	545	Collagen-like 5.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	42		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		GCCAGGCTGTCCTTTTCCAGG	0.512000													10	27					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200965501	200965501	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:200965501C>T	ENST00000332129.2	-	15	2416	c.2100G>A	c.(2098-2100)gaG>gaA	p.E700E	KIF21B_ENST00000461742.2_Silent_p.E700E|KIF21B_ENST00000360529.5_Silent_p.E700E|KIF21B_ENST00000422435.2_Silent_p.E700E	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	700					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						TGGCCTTCTCCTCAGTATAGC	0.592000													46	58					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8722109	8722109	+	Splice_Site	SNP	A	A	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:8722109A>T	ENST00000378641.3	+	23	2888		c.e23-1		PLCB1_ENST00000494924.1_Splice_Site|PLCB1_ENST00000378637.2_Splice_Site|PLCB1_ENST00000338037.6_Splice_Site	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)						activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						TTCCCTATTTAGATGTCATCG	0.388000													8	12					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58097893	58097893	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:58097893C>G	ENST00000357272.4	+	18	2758	c.2593C>G	c.(2593-2595)Ccg>Gcg	p.P865A	FLNB_ENST00000493452.1_Missense_Mutation_p.P696A|FLNB_ENST00000490882.1_Missense_Mutation_p.P865A|FLNB_ENST00000429972.2_Missense_Mutation_p.P865A|FLNB_ENST00000419752.2_Missense_Mutation_p.P696A|FLNB_ENST00000358537.3_Missense_Mutation_p.P865A|FLNB_ENST00000348383.5_Missense_Mutation_p.P865A|FLNB_ENST00000295956.4_Missense_Mutation_p.P865A			O75369	FLNB_HUMAN	filamin B, beta	865					actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		AAATGGGAAACCGACCCACTT	0.512000													37	69					0	0	1	0	0
CTDP1	9150	broad.mit.edu	37	18	77477645	77477645	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr18:77477645C>T	ENST00000299543.7	+	9	2326	c.2179C>T	c.(2179-2181)Ccg>Tcg	p.P727S	CTDP1_ENST00000075430.7_Missense_Mutation_p.P727S	NM_001202504.1|NM_004715.4	NP_001189433.1|NP_004706.3	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1	727	BRCT.				positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|prostate(2)|urinary_tract(1)	35		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		GCAGCTCTTCCCGCTCAGGGA	0.642000													23	33					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37441035	37441035	+	Missense_Mutation	SNP	T	T	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:37441035T>A	ENST00000374660.1	+	12	1624	c.1525T>A	c.(1525-1527)Tct>Act	p.S509T	ANKRD30A_ENST00000361713.1_Missense_Mutation_p.S509T|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.S509T			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	565						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						TGAAGAAAATTCTTGGGATTC	0.318000													14	21					0	0	1	0	0
CR2	1380	broad.mit.edu	37	1	207642046	207642046	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:207642046C>T	ENST00000367057.3	+	3	809	c.620C>T	c.(619-621)cCc>cTc	p.P207L	CR2_ENST00000485707.1_3'UTR|CR2_ENST00000367058.3_Missense_Mutation_p.P207L|CR2_ENST00000367059.3_Missense_Mutation_p.P207L|CR2_ENST00000458541.2_Missense_Mutation_p.P207L	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	207	Sushi 3.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						AGTGCTGTCCCCCCCACATGT	0.403000													44	57					0	0	1	0	0
PODN	127435	broad.mit.edu	37	1	53544091	53544091	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:53544091C>T	ENST00000371500.3	+	10	1337	c.996C>T	c.(994-996)gtC>gtT	p.V332V	PODN_ENST00000395871.2_Silent_p.V209V|PODN_ENST00000312553.5_Silent_p.V351V|RP11-334A14.5_ENST00000447867.1_RNA	NM_001199080.1	NP_001186009.1	Q7Z5L7	PODN_HUMAN	podocan	303					negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						TGTCTCGGGTCCCAGCTGGGC	0.627000													15	44					0	0	1	0	0
ENPP3	5169	broad.mit.edu	37	6	131971257	131971257	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:131971257G>T	ENST00000414305.1	+	4	573	c.245G>T	c.(244-246)tGc>tTc	p.C82F	ENPP3_ENST00000427148.2_Missense_Mutation_p.C48F|ENPP3_ENST00000470930.1_3'UTR|ENPP3_ENST00000357639.3_Missense_Mutation_p.C82F|ENPP3_ENST00000358229.5_Missense_Mutation_p.C82F|ENPP3_ENST00000543135.1_Missense_Mutation_p.C48F			O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 3	82	SMB 1.				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		GGTGATTGCTGCTGGGATTTT	0.403000													24	53					7.92952e-12	8.06913e-12	1	1	0
GFRAL	389400	broad.mit.edu	37	6	55223866	55223866	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:55223866G>A	ENST00000340465.2	+	6	968	c.882G>A	c.(880-882)agG>agA	p.R294R		NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like	294						integral to membrane	receptor activity			NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			GTACCTGTAGGACCATTACAC	0.398000													24	35					0	0	1	0	0
H6PD	9563	broad.mit.edu	37	1	9305506	9305506	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:9305506C>T	ENST00000377403.2	+	2	815	c.513C>T	c.(511-513)gtC>gtT	p.V171V	H6PD_ENST00000602477.1_Silent_p.V182V	NM_004285.3	NP_004276.2	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	171	Glucose 1-dehydrogenase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)	TGCGGGTTGTCCTTGAGAAAC	0.587000													29	16					0	0	1	0	0
OSBPL7	114881	broad.mit.edu	37	17	45891144	45891144	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:45891144C>T	ENST00000007414.3	-	15	1599	c.1408G>A	c.(1408-1410)Gcc>Acc	p.A470T	OSBPL7_ENST00000392507.3_Missense_Mutation_p.A470T	NM_145798.2	NP_665741.1	Q9BZF2	OSBL7_HUMAN	oxysterol binding protein-like 7	470					lipid transport		lipid binding			autonomic_ganglia(1)|endometrium(6)|kidney(2)|large_intestine(5)|liver(2)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32						GGCCCGCTGGCCGCCGGCAGG	0.667000													12	14					0	0	1	0	0
IGHV4-28	28400	broad.mit.edu	37	14	106780540	106780540	+	RNA	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:106780540C>T	ENST00000390612.2	-	0	395																											CGGCCGTGTCCACGGCGGTCA	0.597000													49	115					0	0	1	0	0
ERBB4	2066	broad.mit.edu	37	2	212989614	212989614	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:212989614C>T	ENST00000342788.4	-	2	407	c.97G>A	c.(97-99)Gag>Aag	p.E33K	ERBB4_ENST00000436443.1_Missense_Mutation_p.E33K|ERBB4_ENST00000402597.1_Missense_Mutation_p.E33K	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	33					cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		AGTTTATTCTCCGTTCCTGCA	0.418000										TSP Lung(8;0.080)			13	23					0	0	1	0	0
APLNR	187	broad.mit.edu	37	11	57003960	57003960	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:57003960C>T	ENST00000606794.1	-	1	715	c.519G>A	c.(517-519)ttG>ttA	p.L173L		NM_005161.4	NP_005152.1	P35414	APJ_HUMAN	apelin receptor	173						integral to plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						TGGTGTTCTCCAAGTCCCCGG	0.642000													12	19					0	0	1	0	0
FRS2	10818	broad.mit.edu	37	12	69968623	69968623	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:69968623C>T	ENST00000299293.2	+	10	1925	c.1415C>T	c.(1414-1416)gCc>gTc	p.A472V	FRS2_ENST00000397997.2_Missense_Mutation_p.A472V|FRS2_ENST00000550389.1_Missense_Mutation_p.A472V|FRS2_ENST00000549921.1_Missense_Mutation_p.A472V	NM_001278351.1|NM_006654.3	NP_001265280.1|NP_006645.3	Q8WU20	FRS2_HUMAN	fibroblast growth factor receptor substrate 2	472					activation of MAPKK activity|activation of phospholipase C activity|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|transmembrane receptor protein tyrosine phosphatase signaling pathway	endomembrane system|endosome|integral to plasma membrane|membrane fraction	fibroblast growth factor receptor binding|insulin receptor binding|phosphatase activator activity|transmembrane receptor protein tyrosine kinase adaptor activity			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22	Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.94e-18)|Lung(24;9.68e-05)|OV - Ovarian serous cystadenocarcinoma(12;0.000984)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			GAGCTGTATGCCGTGATAGAC	0.483000													22	31					0	0	1	0	0
OR2T33	391195	broad.mit.edu	37	1	248436378	248436378	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:248436378C>T	ENST00000318021.2	-	1	760	c.739G>A	c.(739-741)Gga>Aga	p.G247R		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	247					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TAAAAGAGTCCCACCACAGCC	0.498000													16	27					0	0	1	0	0
SYT12	91683	broad.mit.edu	37	11	66807424	66807424	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:66807424C>T	ENST00000393946.2	+	7	1533	c.371C>T	c.(370-372)cCc>cTc	p.P124L	SYT12_ENST00000525457.1_Missense_Mutation_p.P124L|SYT12_ENST00000527043.1_Missense_Mutation_p.P124L|SYT12_ENST00000526281.1_3'UTR			Q8IV01	SYT12_HUMAN	synaptotagmin XII	124						cell junction|integral to membrane|synaptic vesicle membrane				NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|urinary_tract(1)	20						GACCTGGCCCCCTATGGGACC	0.622000													21	45					0	0	1	0	0
FBXO40	51725	broad.mit.edu	37	3	121340805	121340805	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:121340805G>A	ENST00000338040.4	+	3	943	c.529G>A	c.(529-531)Gat>Aat	p.D177N		NM_016298.3	NP_057382.2	Q9UH90	FBX40_HUMAN	F-box protein 40	177					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(11)|lung(19)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	46				GBM - Glioblastoma multiforme(114;0.189)		GGGTGGAGTGGATATCGGTTT	0.498000													9	13					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152282472	152282472	+	Silent	SNP	G	G	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:152282472G>T	ENST00000368799.1	-	3	4925	c.4890C>A	c.(4888-4890)tcC>tcA	p.S1630S	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1630	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGGGTTCCTGGAGCCATGTC	0.552000									Ichthyosis				4	177					0.000602214	0.000605356	1	1	0
RANBP1	5902	broad.mit.edu	37	22	20114499	20114499	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr22:20114499C>T	ENST00000402752.1	+	6	753	c.527C>T	c.(526-528)gCc>gTc	p.A176V	RANBP1_ENST00000430524.1_3'UTR|RANBP1_ENST00000331821.3_Missense_Mutation_p.A177V	NM_001278640.1	NP_001265569.1	P43487	RANG_HUMAN	RAN binding protein 1	177					intracellular transport|signal transduction|viral reproduction	nuclear envelope	GDP-dissociation inhibitor activity|GTPase activator activity|Ran GTPase binding			breast(1)|large_intestine(1)|lung(1)|ovary(1)	4	Colorectal(54;0.0993)					AATGATCATGCCGAAAAAGTG	0.473000													22	27					0	0	1	0	0
SERPINB4	6318	broad.mit.edu	37	18	61308107	61308107	+	Splice_Site	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr18:61308107C>T	ENST00000341074.5	-	5	585		c.e5+1		SERPINB4_ENST00000356424.6_Splice_Site	NM_002974.2	NP_002965.1			serpin peptidase inhibitor, clade B (ovalbumin), member 4											breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	42						GGCTCTCCTACCATTCGTTTG	0.453000													7	18					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189871689	189871689	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:189871689C>T	ENST00000304636.3	+	44	3398	c.3228C>T	c.(3226-3228)ccC>ccT	p.P1076P	COL3A1_ENST00000317840.5_Intron	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	1076	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CTGGTGCTCCCGGTCCTGCTG	0.393000													13	22					0	0	1	0	0
PAPLN	89932	broad.mit.edu	37	14	73726012	73726012	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:73726012C>G	ENST00000427855.1	+	16	1846	c.1744C>G	c.(1744-1746)Ccc>Gcc	p.P582A	PAPLN_ENST00000554301.1_Missense_Mutation_p.P582A|PAPLN_ENST00000555445.1_Missense_Mutation_p.P582A|PAPLN_ENST00000381166.3_Missense_Mutation_p.P582A|PAPLN_ENST00000340738.5_Missense_Mutation_p.P555A			O95428	PPN_HUMAN	papilin, proteoglycan-like sulfated glycoprotein	582						proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(3)	42				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		CCAGGAACACCCCTCAGCCAG	0.657000													17	47					0	0	1	0	0
RAP1A	5906	broad.mit.edu	37	1	112240096	112240096	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:112240096G>A	ENST00000369709.3	+	4	339	c.160G>A	c.(160-162)Gaa>Aaa	p.E54K	RAP1A_ENST00000545460.1_Missense_Mutation_p.E54K|RAP1A_ENST00000494982.1_3'UTR|RAP1A_ENST00000356415.1_Missense_Mutation_p.E54K|RAP1A_ENST00000436150.2_Missense_Mutation_p.E54K	NM_002884.2	NP_002875.1	P62834	RAP1A_HUMAN	RAP1A, member of RAS oncogene family	54					activation of MAPKK activity|blood coagulation|energy reserve metabolic process|nerve growth factor receptor signaling pathway|regulation of insulin secretion	cytosol|plasma membrane	GTP binding|GTPase activity	p.E54K(1)		endometrium(1)|large_intestine(2)|lung(3)	6		all_cancers(81;6.79e-06)|all_epithelial(167;2.42e-05)|all_lung(203;0.000105)|Lung NSC(277;0.00021)		Lung(183;0.0183)|Colorectal(144;0.0418)|LUSC - Lung squamous cell carcinoma(189;0.0966)|all cancers(265;0.098)|Epithelial(280;0.0981)|COAD - Colon adenocarcinoma(174;0.141)		GTGTATGCTCGAAATCCTGGA	0.373000													24	35					0	0	1	0	0
SYNJ2	8871	broad.mit.edu	37	6	158509737	158509737	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:158509737C>T	ENST00000355585.4	+	24	3464	c.3389C>T	c.(3388-3390)tCc>tTc	p.S1130F	SYNJ2_ENST00000367122.2_Missense_Mutation_p.S1085F|SYNJ2_ENST00000367112.1_Missense_Mutation_p.S215F|SYNJ2_ENST00000367121.3_Missense_Mutation_p.S1130F	NM_001178088.1|NM_003898.3	NP_001171559.1|NP_003889.1	O15056	SYNJ2_HUMAN	synaptojanin 2	1130							nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			biliary_tract(1)|endometrium(9)|kidney(3)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		TCCATCTCCTCCGGCACCCAT	0.493000													29	42					0	0	1	0	0
UBXN8	7993	broad.mit.edu	37	8	30601695	30601695	+	RNA	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:30601695G>A	ENST00000519246.1	+	0	5							O00124	UBXN8_HUMAN	UBX domain protein 8						single fertilization					central_nervous_system(1)|lung(2)	3						TGCACCAGGCGCTTCCGCCAC	0.627000													5	6					0	0	1	0	0
PADI3	51702	broad.mit.edu	37	1	17594408	17594408	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:17594408C>T	ENST00000375460.3	+	6	643	c.603C>T	c.(601-603)ctC>ctT	p.L201L		NM_016233.2	NP_057317.2	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	201					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|liver(2)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	AACTTGTCCTCCATACCTCCA	0.572000													18	34					0	0	1	0	0
BICC1	80114	broad.mit.edu	37	10	60560736	60560736	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:60560736C>T	ENST00000373886.3	+	14	1949	c.1945C>T	c.(1945-1947)Ccc>Tcc	p.P649S	BICC1_ENST00000263103.1_Missense_Mutation_p.P275S	NM_001080512.1	NP_001073981.1	Q9H694	BICC1_HUMAN	bicaudal C homolog 1 (Drosophila)	649					multicellular organismal development		RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	44						GATGATGTGTCCCTCCAAGGT	0.438000													19	26					0	0	1	0	0
SMCO1	255798	broad.mit.edu	37	3	196234890	196234890	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:196234890G>A	ENST00000397537.2	-	3	669	c.513C>T	c.(511-513)aaC>aaT	p.N171N		NM_001077657.1	NP_001071125.1			single-pass membrane protein with coiled-coil domains 1																		TCTTTACCATGTTAGTAATTA	0.458000													21	21					0	0	1	0	0
ERMARD	55780	broad.mit.edu	37	6	170169683	170169683	+	Silent	SNP	A	A	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:170169683A>G	ENST00000588451.1	+	11	1212	c.699A>G	c.(697-699)agA>agG	p.R233R	C6orf70_ENST00000366772.2_Silent_p.R369R|C6orf70_ENST00000392095.4_Silent_p.R243R|C6orf70_ENST00000366773.3_Silent_p.R369R|C6orf70_ENST00000418781.3_Silent_p.R369R			Q5T6L9	CF070_HUMAN		369						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(1)	20		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.2e-22)|BRCA - Breast invasive adenocarcinoma(81;1.49e-07)|GBM - Glioblastoma multiforme(31;0.00191)		CCCGCATAAGAGATCATTTAA	0.393000													9	15					0	0	1	0	0
PPP1R16B	26051	broad.mit.edu	37	20	37524220	37524220	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:37524220A>C	ENST00000299824.1	+	4	523	c.334A>C	c.(334-336)Aac>Cac	p.N112H	PPP1R16B_ENST00000373331.2_Missense_Mutation_p.N112H|PPP1R16B_ENST00000468265.1_3'UTR	NM_015568.2	NP_056383.1	Q96T49	PP16B_HUMAN	protein phosphatase 1, regulatory subunit 16B	112					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(23)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	49		Myeloproliferative disorder(115;0.00878)				CTGCATCGACAACTTTGAGGA	0.612000													10	14					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131849047	131849047	+	Splice_Site	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:131849047C>T	ENST00000359827.3	-	24	5316	c.4353_splice	c.e24-1	p.E1452_splice	PLXNA4_ENST00000321063.4_Splice_Site_p.E1452_splice			Q9HCM2	PLXA4_HUMAN	plexin A4	1452						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						CCAGCACACTCCTGGAGGTGA	0.592000													11	12					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176016051	176016051	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:176016051G>A	ENST00000510636.1	+	22	3150	c.2876G>A	c.(2875-2877)gGg>gAg	p.G959E	CDHR2_ENST00000261944.5_Missense_Mutation_p.G959E|CDHR2_ENST00000506348.1_Missense_Mutation_p.G959E	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	959	Cadherin 9.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						GATGATTCAGGGAACAATGGC	0.582000													52	91					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34149740	34149740	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:34149740G>A	ENST00000346193.3	-	1	707	c.656C>T	c.(655-657)cCg>cTg	p.P219L		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	219	Pro-rich.							p.P219L(1)		NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						ACTGGACACCGGAGTCTTGGG	0.657000													27	33					0	0	1	0	0
CD2	914	broad.mit.edu	37	1	117297369	117297369	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:117297369G>A	ENST00000369478.3	+	2	286	c.178G>A	c.(178-180)Gaa>Aaa	p.E60K	CD2_ENST00000369477.1_Missense_Mutation_p.E60K	NM_001767.3	NP_001758.2	P06729	CD2_HUMAN	CD2 molecule	60	Ig-like V-type.				blood coagulation|cell surface receptor linked signaling pathway|cell-cell adhesion|induction of apoptosis|leukocyte migration|membrane raft polarization|natural killer cell activation|positive regulation of myeloid dendritic cell activation|regulation of T cell differentiation|T cell activation	integral to plasma membrane	receptor activity			NS(1)|breast(2)|large_intestine(3)|liver(1)|lung(8)|skin(2)|stomach(1)	18	Lung SC(450;0.225)	all_cancers(81;3.15e-06)|Acute lymphoblastic leukemia(138;1.7e-08)|all_epithelial(167;8.38e-07)|all_lung(203;3.37e-06)|Lung NSC(69;2.31e-05)		Epithelial(280;6.71e-26)|OV - Ovarian serous cystadenocarcinoma(397;4.74e-24)|all cancers(265;1.93e-22)|Lung(183;0.0543)|Kidney(133;0.0813)|Colorectal(144;0.174)|KIRC - Kidney renal clear cell carcinoma(1967;0.176)|LUSC - Lung squamous cell carcinoma(189;0.189)|BRCA - Breast invasive adenocarcinoma(282;0.201)	Alefacept(DB00092)	TATAAAATGGGAAAAAACTTC	0.353000													18	12					0	0	1	0	0
POMC	5443	broad.mit.edu	37	2	25384180	25384180	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:25384180C>T	ENST00000405623.1	-	3	1029	c.574G>A	c.(574-576)Gac>Aac	p.D192N	POMC_ENST00000380794.1_Missense_Mutation_p.D192N|POMC_ENST00000264708.3_Missense_Mutation_p.D192N|POMC_ENST00000395826.2_Missense_Mutation_p.D192N			P01189	COLI_HUMAN	proopiomelanocortin	192					cell-cell signaling|cellular nitrogen compound metabolic process|cellular pigmentation|generation of precursor metabolites and energy|hormone biosynthetic process|negative regulation of tumor necrosis factor production|neuropeptide signaling pathway|peptide hormone processing|positive regulation of transcription from RNA polymerase II promoter|regulation of appetite|regulation of blood pressure	extracellular space|stored secretory granule	hormone activity|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(1)	12	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Hydrocortisone(DB00741)|Loperamide(DB00836)|Trilostane(DB01108)	GCAGGGCCGTCGGGGCCATCT	0.701000													8	13					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64489551	64489551	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:64489551G>A	ENST00000358025.3	+	38	5837	c.5607G>A	c.(5605-5607)aaG>aaA	p.K1869K	SYNE2_ENST00000554584.1_Silent_p.K1869K|SYNE2_ENST00000357395.3_5'UTR|SYNE2_ENST00000344113.4_Silent_p.K1869K	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	1869					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AAACAAAAAAGAGTGTGGAAC	0.308000													5	11					0	0	1	0	0
ARFIP1	27236	broad.mit.edu	37	4	153831231	153831231	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:153831231A>G	ENST00000451320.2	+	9	1146	c.982A>G	c.(982-984)Aat>Gat	p.N328D	ARFIP1_ENST00000356064.3_Missense_Mutation_p.N296D|ARFIP1_ENST00000405727.2_Missense_Mutation_p.N296D|ARFIP1_ENST00000429148.2_Missense_Mutation_p.N148D|ARFIP1_ENST00000353617.2_Missense_Mutation_p.N328D			P53367	ARFP1_HUMAN	ADP-ribosylation factor interacting protein 1	328	AH.				intracellular protein transport|regulation of protein secretion	cytosol|Golgi membrane			ARFIP1/FHDC1(2)	cervix(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	14	all_hematologic(180;0.093)					AGTATTGCACAATCAGCTGGT	0.373000													30	45					0	0	1	0	0
BIRC2	329	broad.mit.edu	37	11	102248885	102248885	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:102248885A>G	ENST00000227758.2	+	9	3227	c.1828A>G	c.(1828-1830)Aag>Gag	p.K610E	BIRC2_ENST00000530675.1_Missense_Mutation_p.K561E|BIRC2_ENST00000527910.1_3'UTR|BIRC2_ENST00000532672.1_Missense_Mutation_p.K589E	NM_001166.4|NM_001256163.1	NP_001157.1|NP_001243092.1	Q13490	BIRC2_HUMAN	baculoviral IAP repeat containing 2	610					cell surface receptor linked signaling pathway|cellular component disassembly involved in apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	CD40 receptor complex|cytosol|internal side of plasma membrane	protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|liver(2)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|Epithelial(9;0.11)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0144)		GGGTATAATCAAGGGTACTGT	0.353000													14	14					0	0	1	0	0
RNF165	494470	broad.mit.edu	37	18	44030264	44030264	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr18:44030264C>T	ENST00000269439.7	+	5	672	c.621C>T	c.(619-621)gtC>gtT	p.V207V	RNF165_ENST00000543885.1_Silent_p.V15V	NM_152470.2	NP_689683.2	Q6ZSG1	RN165_HUMAN	ring finger protein 165	207							zinc ion binding			NS(1)|large_intestine(4)|lung(6)	11				READ - Rectum adenocarcinoma(1;0.0873)		AACAGGTCGTCCATGAAATCC	0.522000													20	22					0	0	1	0	0
P2RX4	5025	broad.mit.edu	37	12	121659900	121659900	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:121659900C>T	ENST00000337233.4	+	4	666	c.358C>T	c.(358-360)Cca>Tca	p.P120S	P2RX4_ENST00000540930.1_3'UTR|P2RX4_ENST00000359949.7_Missense_Mutation_p.P136S|P2RX4_ENST00000541532.1_Missense_Mutation_p.P120S|P2RX4_ENST00000543171.1_Missense_Mutation_p.P19S	NM_001261397.1|NM_001261398.1|NM_002560.2	NP_001248326.1|NP_001248327.1|NP_002551.2	Q99571	P2RX4_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 4	120					endothelial cell activation|negative regulation of cardiac muscle hypertrophy|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|regulation of apoptosis|regulation of blood pressure|regulation of sodium ion transport|relaxation of cardiac muscle|response to ATP|response to fluid shear stress|sensory perception of pain|tissue homeostasis	cell junction|perinuclear region of cytoplasm	cadherin binding|copper ion binding|extracellular ATP-gated cation channel activity|protein homodimerization activity|purinergic nucleotide receptor activity|receptor binding|zinc ion binding			breast(1)|kidney(4)|large_intestine(4)|lung(7)|prostate(1)	17	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TTTCCAGATTCCAGATGCGAC	0.627000													32	85					0	0	1	0	0
RERGL	79785	broad.mit.edu	37	12	18241859	18241859	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:18241859G>A	ENST00000229002.2	-	3	293	c.87C>T	c.(85-87)ttC>ttT	p.F29F	RERGL_ENST00000541632.1_5'UTR|RERGL_ENST00000538724.1_Silent_p.F28F|RERGL_ENST00000536890.1_Silent_p.F28F	NM_024730.2	NP_079006.1	Q9H628	RERGL_HUMAN	RERG/RAS-like	29	Small GTPase-like.				signal transduction	membrane	GTP binding|GTPase activity			endometrium(1)|large_intestine(5)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	17						ATTCTCCAATGAATCGCTTAG	0.333000													17	31					0	0	1	0	0
MSL2	55167	broad.mit.edu	37	3	135870069	135870069	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:135870069G>A	ENST00000309993.2	-	2	2386	c.1654C>T	c.(1654-1656)Cca>Tca	p.P552S	MSL2_ENST00000434835.2_Missense_Mutation_p.P478S	NM_018133.3	NP_060603.2	Q9HCI7	MSL2_HUMAN	male-specific lethal 2 homolog (Drosophila)	552					histone H4-K16 acetylation	MSL complex	zinc ion binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	18						GTCGTTACTGGGGACCCTGTG	0.453000													32	49					0	0	1	0	0
OC90	729330	broad.mit.edu	37	8	133036883	133036883	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:133036883C>T	ENST00000262283.5	-	18	2014	c.1915G>A	c.(1915-1917)Gac>Aac	p.D639N	OC90_ENST00000603859.1_Missense_Mutation_p.D427N|OC90_ENST00000254627.3_Missense_Mutation_p.D427N|OC90_ENST00000443356.2_Missense_Mutation_p.D443N			Q02509	OC90_HUMAN	otoconin 90	443					lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			TGCAGGCTGTCTTCACAGGCT	0.647000													14	7					0	0	1	0	0
CERS3	204219	broad.mit.edu	37	15	101042017	101042017	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:101042017C>T	ENST00000284382.4	-	4	461	c.38G>A	c.(37-39)aGa>aAa	p.R13K	CERS3_ENST00000560944.1_Intron|CERS3_ENST00000538112.2_Missense_Mutation_p.R13K|CERS3_ENST00000394113.1_Missense_Mutation_p.R13K	NM_178842.3	NP_849164.2	Q8IU89	CERS3_HUMAN	ceramide synthase 3	13						endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										AAGCCAGAATCTTTCCAACCA	0.373000													48	22					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168845663	168845663	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:168845663C>T	ENST00000464456.1	-	4	1435	c.235G>A	c.(235-237)Gaa>Aaa	p.E79K	MECOM_ENST00000468789.1_Missense_Mutation_p.E79K|MECOM_ENST00000433243.2_Missense_Mutation_p.E79K|MECOM_ENST00000264674.3_Missense_Mutation_p.E143K|MECOM_ENST00000494292.1_Missense_Mutation_p.E267K|MECOM_ENST00000472280.1_Missense_Mutation_p.E79K|MECOM_ENST00000392736.3_Missense_Mutation_p.E79K|MECOM_ENST00000460814.1_Missense_Mutation_p.E79K	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						TGGTCACATTCCTTACACTCC	0.393000													24	49					0	0	1	0	0
DCX	1641	broad.mit.edu	37	X	110654100	110654100	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:110654100C>T	ENST00000338081.3	-	1	274	c.103G>A	c.(103-105)Gaa>Aaa	p.E35K	DCX_ENST00000356915.2_Intron|DCX_ENST00000356220.3_Intron|DCX_ENST00000496551.1_Intron|DCX_ENST00000488120.1_Intron|DCX_ENST00000371993.2_Intron	NM_000555.3	NP_000546.2	O43602	DCX_HUMAN	doublecortin	35					axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(17)|skin(6)|upper_aerodigestive_tract(1)	41						TGACAAAATTCCCCTTGAAGA	0.423000													43	25					0	0	1	0	0
OR52A1	23538	broad.mit.edu	37	11	5172968	5172968	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:5172968C>T	ENST00000380367.1	-	2	1049	c.632G>A	c.(631-633)gGa>gAa	p.G211E	OR52A1_ENST00000328942.1_Missense_Mutation_p.G211E			Q9UKL2	O52A1_HUMAN	olfactory receptor, family 52, subfamily A, member 1	211					sensory perception of smell	integral to plasma membrane	olfactory receptor activity			breast(2)|endometrium(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	19		Medulloblastoma(188;0.00106)|Breast(177;0.0155)|all_neural(188;0.0189)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAGGTCAAATCCTGCTACAGT	0.423000													15	36					0	0	1	0	0
TBC1D32	221322	broad.mit.edu	37	6	121642895	121642895	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:121642895C>T	ENST00000275159.6	-	2	200	c.201G>A	c.(199-201)ttG>ttA	p.L67L	TBC1D32_ENST00000398212.2_Silent_p.L67L					TBC1 domain family, member 32																		TCATAGAACCCAAAGTGTTGC	0.353000													28	42					0	0	1	0	0
C2CD2	25966	broad.mit.edu	37	21	43325929	43325929	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr21:43325929G>A	ENST00000380486.3	-	11	1577	c.1336C>T	c.(1336-1338)Ccc>Tcc	p.P446S	C2CD2_ENST00000329623.7_Missense_Mutation_p.P291S	NM_015500.1	NP_056315.1	Q9Y426	CU025_HUMAN	C2 calcium-dependent domain containing 2	446						cytosol|extracellular region|nucleus				endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|stomach(1)	15						ACCTTGATGGGAGTCTTCACC	0.542000													9	15					0	0	1	0	0
GZF1	64412	broad.mit.edu	37	20	23350920	23350920	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:23350920A>T	ENST00000338121.5	+	6	2055	c.1978A>T	c.(1978-1980)Atg>Ttg	p.M660L	GZF1_ENST00000377051.2_Missense_Mutation_p.M660L|GZF1_ENST00000544236.1_Missense_Mutation_p.M184L|GZF1_ENST00000542987.1_Missense_Mutation_p.M169L			Q9H116	GZF1_HUMAN	GDNF-inducible zinc finger protein 1	660					transcription, DNA-dependent	nucleolus|nucleoplasm	sequence-specific DNA binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|urinary_tract(2)	24	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)					TGTACCTACCATGCAGGAGAA	0.522000													17	21					0	0	1	0	0
NGFR	4804	broad.mit.edu	37	17	47587798	47587798	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:47587798G>A	ENST00000172229.3	+	4	718	c.593G>A	c.(592-594)cGg>cAg	p.R198Q	NGFR_ENST00000504201.1_Missense_Mutation_p.R104Q|RP5-1029K10.2_ENST00000514506.1_RNA	NM_002507.3	NP_002498.1	P08138	TNR16_HUMAN	nerve growth factor receptor	198	Ser/Thr-rich.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|negative regulation of axonogenesis|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis	cell surface|cytosol|endosome|extracellular region|integral to plasma membrane|nucleoplasm				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)	17	all_cancers(4;1.45e-13)|Breast(4;6.34e-28)|all_epithelial(4;4.95e-17)					TGGATTACACGGTCCACACCC	0.617000													19	41					0	0	1	0	0
DYDC2	84332	broad.mit.edu	37	10	82122260	82122260	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:82122260G>A	ENST00000372199.1	+	4	659	c.61G>A	c.(61-63)Gtg>Atg	p.V21M	DYDC2_ENST00000372197.1_Missense_Mutation_p.V21M|DYDC2_ENST00000256039.2_Missense_Mutation_p.V21M|DYDC2_ENST00000444807.2_Missense_Mutation_p.V21M|DYDC2_ENST00000372198.1_Missense_Mutation_p.V35M			Q96IM9	DYDC2_HUMAN	DPY30 domain containing 2	21							protein binding			breast(1)|large_intestine(3)|lung(6)|skin(1)	11			Colorectal(32;0.229)			ACTGGCAGAGGTGGCGAAGGT	0.478000													14	15					0	0	1	0	0
H3F3B	3021	broad.mit.edu	37	17	73774674	73774674	+	Nonstop_Mutation	SNP	A	A	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:73774674A>C	ENST00000592643.1	-	4	451	c.340T>G	c.(340-342)Tga>Gga	p.*114G	H3F3B_ENST00000591890.1_3'UTR|H3F3B_ENST00000589599.1_3'UTR|H3F3B_ENST00000254810.4_3'UTR|H3F3B_ENST00000593254.1_5'UTR|H3F3B_ENST00000586607.1_3'UTR|H3F3B_ENST00000587560.1_3'UTR			P84243	H33_HUMAN	H3 histone, family 3B (H3.3B)	0					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding			large_intestine(1)|lung(4)|ovary(2)|skin(1)	8	all_cancers(13;1.5e-07)		all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			AACTGCCTTCACTTAAGCTCT	0.393000													38	79					0	0	1	0	0
NYAP2	57624	broad.mit.edu	37	2	226447193	226447193	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:226447193C>T	ENST00000272907.6	+	4	1473	c.1060C>T	c.(1060-1062)Ccg>Tcg	p.P354S	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	354	Pro-rich.																CGACGAGTCCCCGCTTACCCC	0.647000													8	16					0	0	1	0	0
TMEM192	201931	broad.mit.edu	37	4	166021932	166021932	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:166021932A>C	ENST00000306480.5	-	3	432	c.287T>G	c.(286-288)aTa>aGa	p.I96R	TMEM192_ENST00000506087.1_Missense_Mutation_p.I92R	NM_001100389.1	NP_001093859.1	Q8IY95	TM192_HUMAN	transmembrane protein 192	96						Golgi apparatus|integral to membrane|late endosome|lysosomal membrane|nucleus				NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)	7	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0926)		CCCAAGGATTATAACCGTCTG	0.383000													27	10					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23883308	23883308	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:23883308C>T	ENST00000355349.3	-	38	5725	c.5563G>A	c.(5563-5565)Gag>Aag	p.E1855K		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1855					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CTGTCCTCCTCCGTCTGGGGG	0.602000													17	27					0	0	1	0	0
PPP1R16A	84988	broad.mit.edu	37	8	145724155	145724155	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:145724155C>T	ENST00000292539.4	+	3	1179	c.262C>T	c.(262-264)Cgc>Tgc	p.R88C	PPP1R16A_ENST00000435887.1_Missense_Mutation_p.R88C|CTD-2517M22.14_ENST00000532766.1_RNA|CTD-2517M14.5_ENST00000569326.1_RNA			Q96I34	PP16A_HUMAN	protein phosphatase 1, regulatory subunit 16A	88						plasma membrane	protein binding			NS(1)|endometrium(1)|kidney(2)|lung(3)|prostate(1)	8	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TTTTGCAGTCCGCCAGTTCCT	0.652000													4	37					0	0	1	0	0
AQP6	363	broad.mit.edu	37	12	50368136	50368136	+	Translation_Start_Site	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:50368136G>A	ENST00000551733.1	+	0	408				AQP6_ENST00000315520.5_Silent_p.A144A			Q13520	AQP6_HUMAN	aquaporin 6, kidney specific						excretion|odontogenesis	integral to plasma membrane|transport vesicle membrane	anion channel activity|water channel activity			endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(2)	13						CTGGCCAGGCGGTGGCAGTGG	0.622000											OREG0021809	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	36					0	0	1	0	0
ZNF324B	388569	broad.mit.edu	37	19	58967343	58967343	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:58967343C>T	ENST00000391696.1	+	3	1934	c.1002C>T	c.(1000-1002)tcC>tcT	p.S334S	ZNF324B_ENST00000545523.1_Silent_p.S344S|ZNF324B_ENST00000336614.4_Silent_p.S344S			Q6AW86	Z324B_HUMAN	zinc finger protein 324B	344					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		TCCGCTGCTCCGAGTGCGGCA	0.687000													11	4					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57767106	57767106	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:57767106G>A	ENST00000371030.2	+	1	1032	c.1032G>A	c.(1030-1032)tcG>tcA	p.S344S		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	344						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GCACCGACTCGGGGTACCTGT	0.736000													8	14					0	0	1	0	0
CTPS2	56474	broad.mit.edu	37	X	16627740	16627740	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:16627740G>A	ENST00000443824.1	-	17	2358	c.1615C>T	c.(1615-1617)Ccg>Tcg	p.P539S	CTPS2_ENST00000380241.3_Missense_Mutation_p.P539S|CTPS2_ENST00000359276.4_Missense_Mutation_p.P539S	NM_001144002.1	NP_001137474.1	Q9NRF8	PYRG2_HUMAN	CTP synthase 2	539	Glutamine amidotransferase type-1.				glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine nucleotide biosynthetic process	cytosol	ATP binding|CTP synthase activity			breast(1)|endometrium(3)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	Hepatocellular(33;0.0997)					CCCAGATACGGAGGGGAAGGC	0.468000													14	22					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94137913	94137913	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:94137913G>A	ENST00000282020.4	+	6	1072	c.814G>A	c.(814-816)Gaa>Aaa	p.E272K	GRID2_ENST00000505687.1_3'UTR|GRID2_ENST00000510992.1_Missense_Mutation_p.E177K	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	272					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	GGACGTACAGGAACTTGTAAG	0.388000													28	34					0	0	1	0	0
HEPHL1	341208	broad.mit.edu	37	11	93808435	93808435	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:93808435C>T	ENST00000315765.9	+	9	1608	c.1600C>T	c.(1600-1602)Ccc>Tcc	p.P534S		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	534	Plastocyanin-like 3.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				TGGTGATCCTCCCTGTCTGAC	0.502000													7	13					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23861779	23861779	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:23861779C>T	ENST00000405093.3	-	25	3404	c.3334G>A	c.(3334-3336)Gaa>Aaa	p.E1112K	MYH6_ENST00000356287.3_Missense_Mutation_p.E1112K	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	1112					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		ACCTGGTTTTCCTTCAGTTTC	0.478000													62	85					0	0	1	0	0
NEK9	91754	broad.mit.edu	37	14	75555296	75555296	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:75555296G>A	ENST00000238616.5	-	20	2649	c.2491C>T	c.(2491-2493)Ctc>Ttc	p.L831F		NM_033116.4	NP_149107.4	Q8TD19	NEK9_HUMAN	NIMA-related kinase 9	831	Interaction with NEK6.|Pro/Ser/Thr-rich.				cell division|mitosis	mitochondrion|nucleus	ATP binding|metal ion binding|protein kinase binding|protein serine/threonine kinase activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	31				BRCA - Breast invasive adenocarcinoma(234;0.00718)		GCTGCACTGAGAGGAGATGGG	0.458000											OREG0022811	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	33					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113231323	113231323	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:113231323C>T	ENST00000401783.2	-	17	3393	c.3057G>A	c.(3055-3057)cgG>cgA	p.R1019R	SVEP1_ENST00000467821.1_5'UTR|SVEP1_ENST00000302728.8_Silent_p.R1019R|SVEP1_ENST00000374469.1_Silent_p.R996R	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	1019					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						AGGATCCGATCCGGCAGCTTT	0.418000													17	15					0	0	1	0	0
VPS39	23339	broad.mit.edu	37	15	42455922	42455922	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:42455922G>A	ENST00000318006.5	-	20	2193	c.2031C>T	c.(2029-2031)ctC>ctT	p.L677L	VPS39_ENST00000348544.4_Silent_p.L688L	NM_015289.2	NP_056104.2	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39 homolog (S. cerevisiae)	688					protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			breast(2)|kidney(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)		GTTCTTCTAAGAGGCCTAGGA	0.498000													3	7					0	0	1	0	0
MCF2	4168	broad.mit.edu	37	X	138684595	138684595	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:138684595C>T	ENST00000520602.1	-	19	2271	c.1986G>A	c.(1984-1986)tgG>tgA	p.W662*	MCF2_ENST00000536274.1_Nonsense_Mutation_p.W563*|MCF2_ENST00000338585.6_Nonsense_Mutation_p.W618*|MCF2_ENST00000519895.1_Nonsense_Mutation_p.W678*|MCF2_ENST00000370578.4_Nonsense_Mutation_p.W747*|MCF2_ENST00000414978.1_Nonsense_Mutation_p.W662*|MCF2_ENST00000370573.4_Nonsense_Mutation_p.W602*|MCF2_ENST00000370576.4_Nonsense_Mutation_p.W602*			P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	602	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			NS(2)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(15)|lung(34)|pancreas(1)|pleura(1)|prostate(1)	62	Acute lymphoblastic leukemia(192;0.000127)					AATACTTCCTCCAAATTGTTT	0.289000													54	21					0	0	1	0	0
GPR50	9248	broad.mit.edu	37	X	150348569	150348569	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:150348569G>A	ENST00000218316.3	+	2	583	c.514G>A	c.(514-516)Gat>Aat	p.D172N		NM_004224.3	NP_004215.2	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	172					cell-cell signaling	integral to plasma membrane	melatonin receptor activity			breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	38	Acute lymphoblastic leukemia(192;6.56e-05)					CATCGAGTACGATCCTCGCAC	0.527000													35	13					0	0	1	0	0
CLEC4C	170482	broad.mit.edu	37	12	7883451	7883451	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:7883451G>A	ENST00000542353.1	-	6	929	c.439C>T	c.(439-441)Cca>Tca	p.P147S	CLEC4C_ENST00000354629.5_Missense_Mutation_p.P116S|CLEC4C_ENST00000540085.1_Missense_Mutation_p.P116S|CLEC4C_ENST00000360345.3_Missense_Mutation_p.P147S	NM_130441.2	NP_569708.1	Q8WTT0	CLC4C_HUMAN	C-type lectin domain family 4, member C	147	C-type lectin.				innate immune response	integral to membrane	sugar binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				Kidney(36;0.0915)		CGACCCCCTGGATCTGACAGC	0.443000													27	38					0	0	1	0	0
HDAC9	9734	broad.mit.edu	37	7	18875207	18875207	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:18875207G>A	ENST00000406451.3	+	20	2725	c.2575G>A	c.(2575-2577)Gag>Aag	p.E859K	HDAC9_ENST00000441542.2_Missense_Mutation_p.E862K|HDAC9_ENST00000432645.2_Missense_Mutation_p.E859K|HDAC9_ENST00000401921.1_Missense_Mutation_p.E818K	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	859	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	AGCCCCAAATGAGGTTCGGTT	0.443000													13	20					0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115997652	115997652	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:115997652G>A	ENST00000264363.2	-	2	1219	c.541C>T	c.(541-543)Ccg>Tcg	p.P181S		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	181	Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		AGGTTTAACGGAAAGCCTTTT	0.378000													18	24					0	0	1	0	0
ABTB1	80325	broad.mit.edu	37	3	127396527	127396527	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:127396527C>T	ENST00000468137.1	+	9	1060	c.444C>T	c.(442-444)ttC>ttT	p.F148F	ABTB1_ENST00000393363.3_Silent_p.F148F|ABTB1_ENST00000232744.8_Silent_p.F290F|ABTB1_ENST00000453791.2_Silent_p.F148F			Q969K4	ABTB1_HUMAN	ankyrin repeat and BTB (POZ) domain containing 1	290	BTB 1.					cytoplasm|nucleolus|plasma membrane	translation elongation factor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	10						AGGCCTTTTTCTGTGGCCGCA	0.682000													7	6					0	0	1	0	0
ZNF318	24149	broad.mit.edu	37	6	43304963	43304963	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:43304963C>T	ENST00000361428.2	-	10	6850	c.6773G>A	c.(6772-6774)gGa>gAa	p.G2258E	ZNF318_ENST00000318149.3_Intron	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	2258					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			TTCAGGCATTCCCTGAGGGAC	0.468000													14	17					0	0	1	0	0
RAG1	5896	broad.mit.edu	37	11	36597009	36597009	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:36597009G>A	ENST00000299440.5	+	2	2267	c.2155G>A	c.(2155-2157)Gaa>Aaa	p.E719K		NM_000448.2	NP_000439.1	P15918	RAG1_HUMAN	recombination activating gene 1	719					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	65	all_lung(20;0.226)	all_hematologic(20;0.107)				GCGGGAAGTGGAAGGCCTCGA	0.488000									Familial Hemophagocytic Lymphohistiocytosis				15	23					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34962098	34962098	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:34962098G>A	ENST00000329357.5	+	1	1186	c.1150G>A	c.(1150-1152)Gaa>Aaa	p.E384K		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	384										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						CCATTTTTGGGAATCCTGTCC	0.557000													23	25					0	0	1	0	0
ZNF626	199777	broad.mit.edu	37	19	20807519	20807519	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:20807519C>T	ENST00000601440.1	-	4	1310	c.1164G>A	c.(1162-1164)aaG>aaA	p.K388K	CTC-513N18.7_ENST00000595094.1_lincRNA	NM_001076675.2	NP_001070143.1	Q68DY1	ZN626_HUMAN	zinc finger protein 626	388					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|lung(3)|skin(1)	6						TATGAATTATCTTATGCGTAG	0.388000													36	60					0	0	1	0	0
ALS2CR11	151254	broad.mit.edu	37	2	202352604	202352604	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:202352604C>T	ENST00000439140.1	-	16	5238	c.5194G>A	c.(5194-5196)Gat>Aat	p.D1732N	ALS2CR11_ENST00000439802.1_3'UTR|ALS2CR11_ENST00000286195.3_Missense_Mutation_p.D535N|ALS2CR11_ENST00000482942.1_5'UTR	NM_001168221.1	NP_001161693.1	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11	535										NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(11)|ovary(1)|skin(5)|urinary_tract(3)	33						TCATGTAAATCCTCAAATTTA	0.299000													19	35					0	0	1	0	0
TAF4	6874	broad.mit.edu	37	20	60578913	60578913	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:60578913G>A	ENST00000252996.3	-	8	2244	c.2245C>T	c.(2245-2247)Cca>Tca	p.P749S	TAF4_ENST00000488539.1_5'UTR	NM_003185.3	NP_003176.2	O00268	TAF4_HUMAN	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa	749					interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			AGGGCTCCTGGCTTCGGAGGC	0.652000													16	23					0	0	1	0	0
SLC44A5	204962	broad.mit.edu	37	1	75683631	75683631	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:75683631G>A	ENST00000370855.5	-	18	1657	c.1544C>T	c.(1543-1545)tCc>tTc	p.S515F	SLC44A5_ENST00000535611.1_Missense_Mutation_p.S385F|SLC44A5_ENST00000370859.3_Missense_Mutation_p.S515F	NM_152697.4	NP_689910.2	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5	515						integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)|large_intestine(13)|lung(35)|ovary(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61						AAATGCTAGGGATCCTGTGTG	0.294000													19	21					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138030231	138030231	+	Splice_Site	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:138030231C>T	ENST00000409968.1	+	11	2573	c.2396_splice	c.e11+1	p.R799_splice	THSD7B_ENST00000272643.3_Splice_Site_p.R799_splice|THSD7B_ENST00000413152.2_Splice_Site_p.R768_splice|THSD7B_ENST00000543459.1_Intron					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		TCCTGTATATCGGCAAGTAGT	0.373000													6	8					0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121638051	121638051	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:121638051G>A	ENST00000393386.2	+	10	1642	c.1231G>A	c.(1231-1233)Gat>Aat	p.D411N	PTPRZ1_ENST00000449182.1_Missense_Mutation_p.D411N	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	411					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity	p.D411Y(4)		NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						CATGCCTACTGATAATCCTGG	0.348000													12	53					0	0	1	0	0
COL17A1	1308	broad.mit.edu	37	10	105815695	105815695	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:105815695G>A	ENST00000353479.5	-	18	1822	c.1532C>T	c.(1531-1533)cCc>cTc	p.P511L	COL17A1_ENST00000480127.1_5'UTR|COL17A1_ENST00000369733.3_Missense_Mutation_p.P511L	NM_000494.3	NP_000485.3	Q9UMD9	COHA1_HUMAN	collagen, type XVII, alpha 1	511	Nonhelical region (NC16).				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|liver(1)|lung(22)|ovary(5)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	62		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GTCCCCATAGGGCAGTATGCT	0.587000													43	63					0	0	1	0	0
IRF2BPL	64207	broad.mit.edu	37	14	77492271	77492271	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:77492271G>A	ENST00000238647.3	-	1	2763	c.1865C>T	c.(1864-1866)tCc>tTc	p.S622F		NM_024496.3	NP_078772.1	Q9H1B7	I2BPL_HUMAN	interferon regulatory factor 2 binding protein-like	622	Pro-rich.					nucleus				endometrium(2)|kidney(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	11						GGCCATAGGGGACGGACCGTT	0.706000													6	7					0	0	1	0	0
CACNG5	27091	broad.mit.edu	37	17	64881234	64881234	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:64881234C>T	ENST00000533854.1	+	6	942	c.705C>T	c.(703-705)gaC>gaT	p.D235D	CACNG5_ENST00000307139.3_Silent_p.D235D			Q9UF02	CCG5_HUMAN	calcium channel, voltage-dependent, gamma subunit 5	235				SAGVMSVYLFMKRYTAEDMYRPHPGFYRPRLSNCSDYSGQF LHPDAWVRGRSPSDISSEASLQMNSNYPALLKCPDYDQMSS SPC -> VKPVTLSMDRLGLGTAPLSRGEWGWGRRDIPQPF WTPDHPLYFPSSSQNVSLSYLSGSPPARMSPGPCSCPHVHF PPHSSCVLCRPQPREMRQAPAASPSSAVFSL (in Ref. 1; AAF03089).	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			NS(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	24			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			TACACCCAGACGCCTGGGTCA	0.637000													20	36					0	0	1	0	0
AKAP4	8852	broad.mit.edu	37	X	49958028	49958028	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:49958028G>A	ENST00000376056.2	-	5	1459	c.1309C>T	c.(1309-1311)Ctg>Ttg	p.L437L	AKAP4_ENST00000481402.1_5'UTR|AKAP4_ENST00000358526.2_Silent_p.L446L|AKAP4_ENST00000376064.3_Silent_p.L437L|AKAP4_ENST00000376058.2_Intron			Q5JQC9	AKAP4_HUMAN	A kinase (PRKA) anchor protein 4	446					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(6)|lung(14)|ovary(1)|skin(4)	41	Ovarian(276;0.236)					GCATATGACAGACTCTGAGAC	0.458000													25	45					0	0	1	0	0
ABCB9	23457	broad.mit.edu	37	12	123425464	123425464	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:123425464G>A	ENST00000542678.1	-	8	4297	c.1459C>T	c.(1459-1461)Ccg>Tcg	p.P487S	ABCB9_ENST00000442833.2_Missense_Mutation_p.P487S|ABCB9_ENST00000442028.2_Missense_Mutation_p.P487S|ABCB9_ENST00000280560.8_Missense_Mutation_p.P487S|ABCB9_ENST00000541983.1_5'UTR|ABCB9_ENST00000392439.3_Missense_Mutation_p.P487S|ABCB9_ENST00000346530.5_Missense_Mutation_p.P444S|ABCB9_ENST00000540285.1_Intron|ABCB9_ENST00000344275.7_Missense_Mutation_p.P487S			Q9NP78	ABCB9_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 9	487					positive regulation of T cell mediated cytotoxicity|protein transport	lysosomal membrane|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(1)|skin(1)	18	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.84e-05)|Epithelial(86;0.000152)|BRCA - Breast invasive adenocarcinoma(302;0.111)		ACCATGGTCGGCTGCCGGTCG	0.642000													3	8					0	0	1	0	0
LRFN1	57622	broad.mit.edu	37	19	39805578	39805578	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:39805578G>A	ENST00000248668.4	-	1	398	c.399C>T	c.(397-399)ctC>ctT	p.L133L	CTC-246B18.8_ENST00000601911.1_RNA	NM_020862.1	NP_065913.1	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III domain containing 1	133						cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			CCAGGCCGCGGAGCTGGTCGC	0.711000													6	9					0	0	1	0	0
RBBP6	5930	broad.mit.edu	37	16	24581168	24581168	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr16:24581168C>T	ENST00000319715.4	+	17	3589	c.3157C>T	c.(3157-3159)Cct>Tct	p.P1053S	RBBP6_ENST00000348022.2_Missense_Mutation_p.P1019S|RBBP6_ENST00000381039.3_Intron	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	1053	Interaction with RB1 (By similarity).				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		TGAGAGATCTCCTCGATCTGA	0.398000													15	27					0	0	1	0	0
DYRK3	8444	broad.mit.edu	37	1	206821315	206821315	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:206821315G>A	ENST00000367106.1	+	4	1185	c.712G>A	c.(712-714)Gag>Aag	p.E238K	DYRK3_ENST00000367108.3_Missense_Mutation_p.E238K|DYRK3_ENST00000489878.1_Intron|DYRK3_ENST00000367109.2_Missense_Mutation_p.E258K			O43781	DYRK3_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3	258	Protein kinase.				erythrocyte differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(9)|lung(8)|skin(1)|stomach(2)	25	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			CCGGATTTTGGAGCATCTTAA	0.448000													38	52					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166848493	166848493	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:166848493G>A	ENST00000423058.2	-	26	5309	c.5292C>T	c.(5290-5292)ttC>ttT	p.F1764F	AC010127.3_ENST00000595647.1_RNA|AC010127.3_ENST00000597623.1_RNA|SCN1A_ENST00000409050.1_Silent_p.F1736F|SCN1A_ENST00000303395.4_Silent_p.F1764F|SCN1A_ENST00000375405.3_Silent_p.F1753F	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1764						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TGACAAAAAAGAAAATTCCAA	0.453000													44	82					0	0	1	0	0
OBP2A	29991	broad.mit.edu	37	9	138440507	138440507	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:138440507C>T	ENST00000340780.3	+	5	449	c.407C>T	c.(406-408)gCc>gTc	p.A136V	OBP2A_ENST00000342114.4_Silent_p.G91G|OBP2A_ENST00000539850.1_Intron|OBP2A_ENST00000371776.1_Intron			Q9NY56	OBP2A_HUMAN	odorant binding protein 2A	0					response to stimulus|sensory perception of smell	extracellular region	odorant binding|transporter activity			endometrium(1)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	11				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		CCCTGCAGGGCCGTGCCGCTG	0.612000													5	0					0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115997651	115997651	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:115997651G>A	ENST00000264363.2	-	2	1220	c.542C>T	c.(541-543)cCg>cTg	p.P181L		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	181	Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		AAGGTTTAACGGAAAGCCTTT	0.378000													18	25					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36874421	36874421	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:36874421G>A	ENST00000429976.2	-	21	6768	c.6521C>T	c.(6520-6522)gCc>gTc	p.A2174V	TRANK1_ENST00000428977.2_Missense_Mutation_p.A1624V|TRANK1_ENST00000301807.6_Missense_Mutation_p.A1624V			O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2174					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						TAAACACTTGGCTTCACAACG	0.423000													10	5					0	0	1	0	0
MYOZ3	91977	broad.mit.edu	37	5	150051332	150051332	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:150051332G>A	ENST00000297130.4	+	5	485	c.286G>A	c.(286-288)Ggc>Agc	p.G96S	MYOZ3_ENST00000517768.1_Missense_Mutation_p.G96S|CTC-345K18.2_ENST00000511626.2_RNA	NM_001122853.2|NM_133371.4	NP_001116325.1|NP_588612.2	Q8TDC0	MYOZ3_HUMAN	myozenin 3	96	Binding to FLNC.					sarcomere	protein binding			large_intestine(2)|lung(1)|skin(2)	5		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAATGCCAATGGCCCTGAGGG	0.731000													12	22					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6120828	6120828	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:6120828G>A	ENST00000261405.5	-	34	6051	c.5797C>T	c.(5797-5799)Cct>Tct	p.P1933S		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	1933					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	ACTTTAACAGGGGACTGGCTG	0.602000													8	12					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32633017	32633017	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:32633017G>A	ENST00000242310.4	-	1	2650	c.2561C>T	c.(2560-2562)cCt>cTt	p.P854L		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	854					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TGAATGGGAAGGAAAGGCTTT	0.438000													19	42					0	0	1	0	0
ATXN7L2	127002	broad.mit.edu	37	1	110032593	110032593	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:110032593C>T	ENST00000369870.3	+	8	1094	c.1079C>T	c.(1078-1080)cCc>cTc	p.P360L		NM_153340.4	NP_699171.3	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	360										breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)	17		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		GATGAAGGCCCCTGTGGTGGT	0.637000													47	88					0	0	1	0	0
CHDC2	286464	broad.mit.edu	37	X	36162702	36162702	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:36162702G>A	ENST00000378660.1	+	11	1473	c.1285G>A	c.(1285-1287)Gag>Aag	p.E429K	CHDC2_ENST00000313548.4_Missense_Mutation_p.E429K					calponin homology domain containing 2																		gtttccaaaggagatggatgc	0.468000													21	23					0	0	1	0	0
AFF4	27125	broad.mit.edu	37	5	132232751	132232751	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:132232751G>A	ENST00000265343.5	-	11	1950	c.1571C>T	c.(1570-1572)aCg>aTg	p.T524M	AFF4_ENST00000378595.3_Missense_Mutation_p.T524M	NM_014423.3	NP_055238.1	Q9UHB7	AFF4_HUMAN	AF4/FMR2 family, member 4	524					transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity		SEPT8/AFF4(2)	breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(7)|lung(11)|ovary(3)|pancreas(1)|prostate(3)|skin(2)	43		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AGCGGAACTCGTTTCTTTAGG	0.507000													8	74					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56386357	56386357	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:56386357C>T	ENST00000355701.3	-	22	5146	c.4276G>A	c.(4276-4278)Gaa>Aaa	p.E1426K	BZRAP1_ENST00000343736.4_Missense_Mutation_p.E1426K|BZRAP1_ENST00000268893.6_Missense_Mutation_p.E1366K	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1426						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTGCAGTGTTCTCGGGGATCT	0.662000													25	128					0	0	1	0	0
TRIM55	84675	broad.mit.edu	37	8	67062009	67062009	+	Missense_Mutation	SNP	C	C	T	rs140278864		TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:67062009C>T	ENST00000315962.4	+	5	1106	c.733C>T	c.(733-735)Cgt>Tgt	p.R245C	TRIM55_ENST00000276573.7_Missense_Mutation_p.R245C|TRIM55_ENST00000353317.5_Missense_Mutation_p.R245C|TRIM55_ENST00000350034.4_Intron	NM_184085.1	NP_908973.1	Q9BYV6	TRI55_HUMAN	tripartite motif containing 55	245						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	39		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			GGAACATGTCCGTGCTCTGAT	0.418000													14	60					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	21954063	21954063	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:21954063C>T	ENST00000261200.4	-	38	4564	c.4565G>A	c.(4564-4566)gGa>gAa	p.G1522E		NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	1522	ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity	p.G1522E(1)		NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TAAAATATTTCCTCGCTTCAT	0.408000													15	22					0	0	1	0	0
UBE3B	89910	broad.mit.edu	37	12	109940906	109940906	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:109940906C>T	ENST00000342494.3	+	14	1956	c.1361C>T	c.(1360-1362)tCt>tTt	p.S454F	UBE3B_ENST00000434735.2_Missense_Mutation_p.S454F|UBE3B_ENST00000535900.1_3'UTR|UBE3B_ENST00000280774.5_Missense_Mutation_p.S454F	NM_130466.3	NP_569733.2	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	454					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			NS(1)|breast(3)|endometrium(6)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|urinary_tract(2)	45						CGGGTCGACTCTGCAGAAGTC	0.517000													25	23					0	0	1	0	0
LRP6	4040	broad.mit.edu	37	12	12317359	12317359	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:12317359G>A	ENST00000261349.4	-	9	1976	c.1900C>T	c.(1900-1902)Ctt>Ttt	p.L634F	LRP6_ENST00000543091.1_Missense_Mutation_p.L634F	NM_002336.2	NP_002327.2	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein 6	634	Beta-propeller 3.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				GAAAACAAAAGGAAAGCCTCT	0.453000													22	39					0	0	1	0	0
HSCB	150274	broad.mit.edu	37	22	29139878	29139878	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr22:29139878C>T	ENST00000216027.3	+	2	310	c.245C>T	c.(244-246)tCc>tTc	p.S82F	HSCB_ENST00000398941.2_Missense_Mutation_p.S82F|HSCB_ENST00000495977.1_3'UTR	NM_172002.3	NP_741999.3	Q8IWL3	HSC20_HUMAN	HscB mitochondrial iron-sulfur cluster co-chaperone	82	J.				iron-sulfur cluster assembly|protein folding	mitochondrion	chaperone binding|heat shock protein binding|metal ion binding			kidney(1)|lung(2)|skin(1)	4						AGCAACCGTTCCTTCAGAGTT	0.448000													35	36					0	0	1	0	0
LRRC61	65999	broad.mit.edu	37	7	150034381	150034381	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:150034381C>T	ENST00000359623.4	+	3	1019	c.431C>T	c.(430-432)cCc>cTc	p.P144L	LRRC61_ENST00000323078.7_Missense_Mutation_p.P144L|LRRC61_ENST00000493307.1_Missense_Mutation_p.P144L	NM_001142928.1	NP_001136400.1	Q9BV99	LRC61_HUMAN	leucine rich repeat containing 61	144	LRRCT.									endometrium(2)|large_intestine(1)|skin(1)|upper_aerodigestive_tract(1)	5			OV - Ovarian serous cystadenocarcinoma(82;0.011)			TGTGCCAACCCCTCCTACTGG	0.652000													13	33					0	0	1	0	0
TJP1	7082	broad.mit.edu	37	15	29997826	29997826	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:29997826G>A	ENST00000346128.6	-	26	5448	c.4974C>T	c.(4972-4974)atC>atT	p.I1658I	TJP1_ENST00000400011.2_Silent_p.I1582I|TJP1_ENST00000545208.2_Silent_p.I1578I|TJP1_ENST00000356107.6_Silent_p.I1658I	NM_003257.3|NM_175610.2	NP_003248.3|NP_783297.2	Q07157	ZO1_HUMAN	tight junction protein 1	1658	ZU5.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		CTCCTTGAGGGATAATTATAC	0.458000													16	59					0	0	1	0	0
TSSC2	650368	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													4	32					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	6903560	6903560	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:6903560C>T	ENST00000486284.1	+	1	759	c.485C>T	c.(484-486)tCc>tTc	p.S162F	GRM7_ENST00000389336.4_Missense_Mutation_p.S162F|GRM7_ENST00000357716.4_Missense_Mutation_p.S162F|GRM7_ENST00000403881.1_Missense_Mutation_p.S162F|GRM7_ENST00000402647.2_Missense_Mutation_p.S162F	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	162					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	AGTTCGGTCTCCATCATGGTA	0.602000													15	25					0	0	1	0	0
BMP2	650	broad.mit.edu	37	20	6759583	6759583	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:6759583G>C	ENST00000378827.4	+	3	2257	c.1038G>C	c.(1036-1038)caG>caC	p.Q346H		NM_001200.2	NP_001191.1	P12643	BMP2_HUMAN	bone morphogenetic protein 2	346					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)	13					Simvastatin(DB00641)	CCATTGTTCAGACGTTGGTCA	0.493000													13	17					0	0	1	0	0
LMAN2	10960	broad.mit.edu	37	5	176764412	176764412	+	Silent	SNP	G	G	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:176764412G>C	ENST00000303127.7	-	5	831	c.627C>G	c.(625-627)cgC>cgG	p.R209R	LMAN2_ENST00000515209.1_Silent_p.R209R	NM_006816.2	NP_006807.1	Q12907	LMAN2_HUMAN	lectin, mannose-binding 2	209	L-type lectin-like.				protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	metal ion binding|sugar binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|upper_aerodigestive_tract(1)	16	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGTCGTGATCGCGGTTGCGGA	0.662000													9	17					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87196230	87196230	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:87196230G>A	ENST00000265724.3	-	7	818	c.401C>T	c.(400-402)tCa>tTa	p.S134L	ABCB1_ENST00000543898.1_Intron	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	134	ABC transmembrane type-1 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GCACCAAAATGAAACCTGAAT	0.418000													14	27					0	0	1	0	0
MARCH10	162333	broad.mit.edu	37	17	60814014	60814014	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:60814014G>A	ENST00000544856.2	-	7	1590	c.1212C>T	c.(1210-1212)acC>acT	p.T404T	RP11-156L14.1_ENST00000577270.1_RNA|MARCH10_ENST00000456609.2_Silent_p.T405T|MARCH10_ENST00000583600.1_Silent_p.T443T|MARCH10_ENST00000311269.5_Silent_p.T405T|RP11-156L14.1_ENST00000582564.1_RNA			Q8NA82	MARHA_HUMAN	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	405							ligase activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|liver(1)|lung(15)	38						GCTCGGATTTGGTGTCCCACG	0.502000													23	48					0	0	1	0	0
VNN3	55350	broad.mit.edu	37	6	133048110	133048110	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:133048110C>T	ENST00000414302.2	-	3	385	c.386G>A	c.(385-387)aGg>aAg	p.R129K	VNN3_ENST00000425515.2_3'UTR|VNN3_ENST00000427187.2_Intron|VNN3_ENST00000367927.5_Silent_p.K193K|VNN3_ENST00000275223.3_Intron|VNN3_ENST00000519686.2_Intron|VNN3_ENST00000392393.3_Intron|VNN3_ENST00000417437.2_Intron|VNN3_ENST00000207771.3_Silent_p.K193K|VNN3_ENST00000450865.2_Intron|VNN3_ENST00000509351.1_Intron|VNN3_ENST00000423615.2_Intron					vanin 3											cervix(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)|stomach(1)	8	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00242)|GBM - Glioblastoma multiforme(226;0.0168)		GTTCTGAATCCTTGGGGAAAT	0.363000													8	6					0	0	1	0	0
MYO3B	140469	broad.mit.edu	37	2	171243660	171243660	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:171243660C>T	ENST00000334231.6	+	14	1446	c.1446C>T	c.(1444-1446)tcC>tcT	p.S482S	MYO3B_ENST00000602629.1_3'UTR|MYO3B_ENST00000408978.4_Silent_p.S473S|MYO3B_ENST00000409044.3_Silent_p.S473S			Q8WXR4	MYO3B_HUMAN	myosin IIIB	473	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						AAGTCAACTCCCTGGTGGAAG	0.443000													13	25					0	0	1	0	0
GPC5	2262	broad.mit.edu	37	13	93518536	93518536	+	Splice_Site	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr13:93518536G>A	ENST00000377067.3	+	8	1935	c.1561_splice	c.e8-1	p.W521_splice		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	521						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				CCTCTACAGGGATGCCAGATG	0.428000													49	9					0	0	1	0	0
RLIM	51132	broad.mit.edu	37	X	73812150	73812150	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:73812150G>A	ENST00000332687.6	-	4	1218	c.1000C>T	c.(1000-1002)Cgg>Tgg	p.R334W	RLIM_ENST00000349225.2_Missense_Mutation_p.R334W	NM_016120.3	NP_057204.2	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	334					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding	p.R334W(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TCTCTCTGCCGATATTCTCCA	0.473000													14	5					0	0	1	0	0
CCDC70	83446	broad.mit.edu	37	13	52439656	52439656	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr13:52439656G>A	ENST00000242819.4	+	2	438	c.142G>A	c.(142-144)Gaa>Aaa	p.E48K		NM_031290.2	NP_112580.2	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70	48						extracellular region|plasma membrane				breast(1)|large_intestine(4)|lung(7)|skin(2)|urinary_tract(1)	15		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		GCTGCAGGAGGAAAAGGCTTT	0.507000													66	9					0	0	1	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73071486	73071486	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:73071486C>G	ENST00000263674.3	+	11	4678	c.4328C>G	c.(4327-4329)cCc>cGc	p.P1443R		NM_014786.3	NP_055601.2	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1443					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(2)	32						GCCACTCGGCCCGAGGGCACC	0.617000													41	70					0	0	1	0	0
MIR1179	100302235	broad.mit.edu	37	15	89151351	89151351	+	RNA	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:89151351G>A	ENST00000408703.1	+	0	14					NR_031590.1																						TGGAAAGGAAGAAGCATTCTT	0.378000													36	62					0	0	1	0	0
REXO4	57109	broad.mit.edu	37	9	136282787	136282787	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:136282787G>C	ENST00000371942.3	-	1	377	c.178C>G	c.(178-180)Cca>Gca	p.P60A	REXO4_ENST00000478037.1_5'UTR|ADAMTS13_ENST00000485925.1_Intron|REXO4_ENST00000371935.2_Missense_Mutation_p.P60A	NM_020385.2	NP_065118.2	Q9GZR2	REXO4_HUMAN	REX4, RNA exonuclease 4 homolog (S. cerevisiae)	60						nucleolus	exonuclease activity|nucleic acid binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(4)|lung(7)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	15				OV - Ovarian serous cystadenocarcinoma(145;8.58e-08)|Epithelial(140;9.55e-07)|all cancers(34;1.05e-05)		GGTGCCTTTGGAGGTCGCACC	0.567000													49	23					0	0	1	0	0
PHACTR4	65979	broad.mit.edu	37	1	28793028	28793028	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:28793028C>T	ENST00000373839.3	+	6	833	c.572C>T	c.(571-573)tCc>tTc	p.S191F	PHACTR4_ENST00000493669.1_3'UTR|PHACTR4_ENST00000373836.3_Missense_Mutation_p.S201F	NM_001048183.1	NP_001041648.1	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4	191							actin binding|protein phosphatase inhibitor activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		GATGCCACTTCCTCTGGCGGC	0.522000													20	35					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36874203	36874203	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:36874203C>T	ENST00000429976.2	-	21	6986	c.6739G>A	c.(6739-6741)Gaa>Aaa	p.E2247K	TRANK1_ENST00000428977.2_Missense_Mutation_p.E1697K|TRANK1_ENST00000301807.6_Missense_Mutation_p.E1697K			O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2247					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						TTGAGGATTTCTTTGCATGCC	0.433000													21	30					0	0	1	0	0
AQP8	343	broad.mit.edu	37	16	25235700	25235700	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr16:25235700G>A	ENST00000219660.5	+	4	530	c.405G>A	c.(403-405)gaG>gaA	p.E135E	AQP8_ENST00000566125.1_Silent_p.E129E	NM_001169.2	NP_001160.2	O94778	AQP8_HUMAN	aquaporin 8	135					cellular response to cAMP	integral to plasma membrane	water channel activity			NS(1)|breast(1)|large_intestine(3)|lung(8)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	16				GBM - Glioblastoma multiforme(48;0.044)		GTCCTGAGGAGAGGTTCTGGA	0.607000													6	11					0	0	1	0	0
POLQ	10721	broad.mit.edu	37	3	121207085	121207085	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:121207085G>A	ENST00000264233.5	-	16	4821	c.4693C>T	c.(4693-4695)Cag>Tag	p.Q1565*		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	1565					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		TCAACCATCTGAACAGAATCC	0.343000								DNA polymerases (catalytic subunits)					20	27					0	0	1	0	0
CCNB3	85417	broad.mit.edu	37	X	50089806	50089806	+	Splice_Site	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:50089806G>A	ENST00000376042.1	+	10	4108	c.3810_splice	c.e10+1	p.R1270_splice	CCNB3_ENST00000276014.7_Splice_Site_p.R1270_splice|CCNB3_ENST00000376038.1_Splice_Site_p.R166_splice|CCNB3_ENST00000348603.2_Splice_Site_p.R166_splice			Q8WWL7	CCNB3_HUMAN	cyclin B3	1270					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					GATATGCTAGGGTAAGAGAGA	0.463000													5	10					0	0	1	0	0
ZNF488	118738	broad.mit.edu	37	10	48371278	48371278	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:48371278C>T	ENST00000395702.2	+	2	973	c.746C>T	c.(745-747)cCc>cTc	p.P249L	ZNF488_ENST00000494156.1_3'UTR|ZNF488_ENST00000586537.1_Missense_Mutation_p.P142L			Q96MN9	ZN488_HUMAN	zinc finger protein 488	249			P -> S (in dbSNP:rs3814160).		regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|ovary(2)	14						GCCCAGGTGCCCCCACCCTCA	0.592000													20	16					0	0	1	0	0
ZNF101	94039	broad.mit.edu	37	19	19790846	19790846	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:19790846C>T	ENST00000592502.1	+	4	1158	c.1048C>T	c.(1048-1050)Ccc>Tcc	p.P350S	ZNF101_ENST00000415784.2_Missense_Mutation_p.P230S			Q8IZC7	ZN101_HUMAN	zinc finger protein 101	350					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(4)|ovary(2)|prostate(1)	17						CTTCAATTATCCCAGTTGTTT	0.408000													33	29					0	0	1	0	0
SDR39U1	56948	broad.mit.edu	37	14	24911630	24911630	+	Silent	SNP	G	G	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:24911630G>T	ENST00000399395.3	-	2	78	c.45C>A	c.(43-45)gcC>gcA	p.A15A	SDR39U1_ENST00000555365.1_5'UTR|SDR39U1_ENST00000554698.1_5'UTR|SDR39U1_ENST00000553930.1_5'UTR|SDR39U1_ENST00000538105.2_5'UTR	NM_020195.2	NP_064580.2	Q9NRG7	D39U1_HUMAN	short chain dehydrogenase/reductase family 39U, member 1	0							binding			NS(1)|central_nervous_system(1)|large_intestine(2)|pancreas(1)	5						GCTGGGTTAGGGCTGTCCCAA	0.607000													3	4					6.4e-05	6.44041e-05	1	1	0
IRF4	3662	broad.mit.edu	37	6	407524	407524	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:407524T>C	ENST00000380956.4	+	9	1408	c.1282T>C	c.(1282-1284)Tac>Cac	p.Y428H		NM_001195286.1|NM_002460.3	NP_001182215.1|NP_002451.2	Q15306	IRF4_HUMAN	interferon regulatory factor 4	428					interferon-gamma-mediated signaling pathway|positive regulation of interleukin-10 biosynthetic process|positive regulation of interleukin-13 biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of transcription, DNA-dependent|regulation of T-helper cell differentiation|T cell activation|type I interferon-mediated signaling pathway	cytoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)	5		Breast(5;0.0155)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.03)|BRCA - Breast invasive adenocarcinoma(62;0.0702)		CCTGAGGGGCTACGATTTACC	0.368000			T	IGH@	MM								10	40					0	0	1	0	0
PDIA5	10954	broad.mit.edu	37	3	122825641	122825641	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:122825641G>A	ENST00000316218.7	+	6	528	c.433G>A	c.(433-435)Gag>Aag	p.E145K		NM_006810.3	NP_006801.1	Q14554	PDIA5_HUMAN	protein disulfide isomerase family A, member 5	145	Thioredoxin 1.				cell redox homeostasis|glycerol ether metabolic process|protein folding|response to stress	endoplasmic reticulum lumen	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			breast(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	21				GBM - Glioblastoma multiforme(114;0.0427)		CCCACTGTGGGAGGAAGATCC	0.478000													18	34					0	0	1	0	0
HMGCS1	3157	broad.mit.edu	37	5	43298699	43298699	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:43298699G>A	ENST00000325110.6	-	3	575	c.369C>T	c.(367-369)atC>atT	p.I123I	HMGCS1_ENST00000433297.2_Silent_p.I123I	NM_001098272.2	NP_001091742.1	Q01581	HMCS1_HUMAN	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	123					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|soluble fraction	hydroxymethylglutaryl-CoA synthase activity			NS(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|stomach(1)|urinary_tract(1)	15						TAGTTGTGTCGATTCCTTCTA	0.428000													26	34					0	0	1	0	0
VPS33A	65082	broad.mit.edu	37	12	122735588	122735588	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:122735588G>A	ENST00000267199.4	-	5	654	c.542C>T	c.(541-543)aCc>aTc	p.T181I	RP11-512M8.5_ENST00000535844.1_Intron	NM_022916.4	NP_075067.2	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33 homolog A (S. cerevisiae)	181					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(13)|ovary(1)|skin(2)	28	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		AGCTTGCAGGGTCATCAGCCC	0.582000													20	33					0	0	1	0	0
CCDC144A	9720	broad.mit.edu	37	17	16610839	16610839	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:16610839G>A	ENST00000443444.2	+	4	861	c.721G>A	c.(721-723)Gaa>Aaa	p.E241K	CCDC144A_ENST00000456009.1_Missense_Mutation_p.E241K|CCDC144A_ENST00000436374.1_3'UTR|RP11-219A15.1_ENST00000448331.3_Missense_Mutation_p.E241K|CCDC144A_ENST00000360524.8_Missense_Mutation_p.E241K|CCDC144A_ENST00000340621.5_Missense_Mutation_p.E240K|CCDC144A_ENST00000399273.1_Missense_Mutation_p.E241K			A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	241																	TAAAGGATGCGAAAATAAGCA	0.348000													3	10					0	0	1	0	0
GAS2L2	246176	broad.mit.edu	37	17	34074184	34074184	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:34074184G>A	ENST00000254466.6	-	5	963	c.936C>T	c.(934-936)agC>agT	p.S312S	GAS2L2_ENST00000587565.1_Silent_p.S296S	NM_139285.3	NP_644814.1	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	312					cell cycle arrest	cytoplasm|cytoskeleton				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TCTGTGAGCGGCTGATGGTCA	0.627000													39	63					0	0	1	0	0
GANAB	23193	broad.mit.edu	37	11	62393362	62393362	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:62393362G>A	ENST00000346178.4	-	25	2841	c.2826C>T	c.(2824-2826)gaC>gaT	p.D942D	GANAB_ENST00000540933.1_Silent_p.D823D|GANAB_ENST00000356638.3_Silent_p.D920D|GANAB_ENST00000534779.1_Silent_p.D828D	NM_001278192.1|NM_198335.2	NP_001265121.1|NP_938149.2	Q14697	GANAB_HUMAN	glucosidase, alpha; neutral AB	920					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|skin(2)|urinary_tract(3)	35						AGGTCTCAGGGTCATGCTGGA	0.507000													11	20					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167254679	167254679	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:167254679G>C	ENST00000308378.3	-	7	1182	c.877C>G	c.(877-879)Cct>Gct	p.P293A	WDR49_ENST00000479765.1_Intron|WDR49_ENST00000453925.2_Missense_Mutation_p.P357A|WDR49_ENST00000476376.1_Missense_Mutation_p.P118A	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	293										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						GTTTGTGGAGGTAAAAACGCA	0.388000													7	14					0	0	1	0	0
SLC35F2	54733	broad.mit.edu	37	11	107663440	107663440	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:107663440C>T	ENST00000525071.1	-	11	1607	c.1019G>A	c.(1018-1020)cGg>cAg	p.R340Q	SLC35F2_ENST00000265836.7_Silent_p.P194P|SLC35F2_ENST00000429869.1_Silent_p.P342P|SLC35F2_ENST00000525815.1_Silent_p.P342P|SLC35F2_ENST00000375682.4_Silent_p.P295P			Q8IXU6	S35F2_HUMAN	solute carrier family 35, member F2	0					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(61;9.46e-06)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;0.000111)|all_hematologic(158;0.000315)|all_epithelial(67;0.00197)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)|Epithelial(105;0.000105)|all cancers(92;0.00217)		TGCTTTCAGCCGGCTCGGCCG	0.557000													4	14					0	0	1	0	0
SPAG4	6676	broad.mit.edu	37	20	34207659	34207659	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:34207659C>T	ENST00000374273.3	+	10	1180	c.1068C>T	c.(1066-1068)ttC>ttT	p.F356F		NM_003116.1	NP_003107.1	Q9NPE6	SPAG4_HUMAN	sperm associated antigen 4	356	SUN.				spermatogenesis	cilium|flagellar axoneme|integral to membrane	structural molecule activity			NS(1)|cervix(5)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)	21	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			CCCGCGATTTCGCGGTCTTTG	0.617000													16	19					0	0	1	0	0
C8orf34	116328	broad.mit.edu	37	8	69351797	69351797	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:69351797C>T	ENST00000337103.4	+	1	1650	c.58C>T	c.(58-60)Ctt>Ttt	p.L20F	C8orf34_ENST00000348340.2_Missense_Mutation_p.L45F|C8orf34_ENST00000518698.1_Missense_Mutation_p.L131F|C8orf34_ENST00000539993.1_Missense_Mutation_p.L45F|C8orf34_ENST00000349492.3_3'UTR|C8orf34_ENST00000523686.1_Missense_Mutation_p.L45F			Q49A92	CH034_HUMAN	chromosome 8 open reading frame 34	45					signal transduction		cAMP-dependent protein kinase regulator activity			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(12)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	36			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			CATTGACCATCTTCAGTCTAA	0.388000													22	36					0	0	1	0	0
FGF7	2252	broad.mit.edu	37	15	49716767	49716767	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:49716767G>A	ENST00000267843.4	+	2	884	c.273G>A	c.(271-273)atG>atA	p.M91I	FAM227B_ENST00000299338.6_Intron|FAM227B_ENST00000561064.1_Intron|FGF7_ENST00000560270.1_Missense_Mutation_p.M91I	NM_002009.3	NP_002000.1	P21781	FGF7_HUMAN	fibroblast growth factor 7	91					actin cytoskeleton reorganization|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|mesenchymal cell proliferation|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|protein localization at cell surface|secretion by lung epithelial cell involved in lung growth		chemoattractant activity|growth factor activity			kidney(1)|large_intestine(1)|lung(2)|prostate(1)	5		all_lung(180;0.00391)		all cancers(107;3.61e-08)|GBM - Glioblastoma multiforme(94;4.06e-05)	Palifermin(DB00039)	CCCAAGAGATGAAGAATAATT	0.378000													9	20					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168106668	168106668	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:168106668G>A	ENST00000409195.1	+	9	8855	c.8766G>A	c.(8764-8766)caG>caA	p.Q2922Q	XIRP2_ENST00000295237.9_Silent_p.Q2922Q|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Silent_p.Q2700Q|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2747					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AGATTACACAGAACAAATCTT	0.373000													23	31					0	0	1	0	0
PSG3	5671	broad.mit.edu	37	19	43234015	43234015	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:43234015C>T	ENST00000327495.5	-	4	1087	c.903G>A	c.(901-903)acG>acA	p.T301T	PSG3_ENST00000595140.1_Silent_p.T301T	NM_021016.3	NP_066296.2	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	301	Ig-like C2-type 2.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36		Prostate(69;0.00682)				TTTCATTTCTCGTGACACTGG	0.483000													46	115					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108112956	108112956	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:108112956G>A	ENST00000273353.3	-	37	5297	c.5241C>T	c.(5239-5241)gcC>gcT	p.A1747A		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1747						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						TCTGCATCCGGGCAACATCAG	0.488000													30	32					0	0	1	0	0
VWA7	80737	broad.mit.edu	37	6	31735178	31735178	+	Nonsense_Mutation	SNP	G	G	A	rs138415590	by1000genomes	TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:31735178G>A	ENST00000375686.3	-	12	1987	c.1750C>T	c.(1750-1752)Cag>Tag	p.Q584*	VWA7_ENST00000447450.1_Nonsense_Mutation_p.Q584*|VWA7_ENST00000375688.4_Nonsense_Mutation_p.Q584*|VWA7_ENST00000467576.1_5'UTR	NM_025258.2	NP_079534.2	Q9Y334	G7C_HUMAN	von Willebrand factor A domain containing 7	584						extracellular region											GCTGTGACCTGGATCTCCCAG	0.602000													35	19					0	0	1	0	0
HDAC1	3065	broad.mit.edu	37	1	32792652	32792652	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:32792652C>T	ENST00000373548.3	+	5	552	c.468C>T	c.(466-468)atC>atT	p.I156I	HDAC1_ENST00000373541.2_5'UTR	NM_004964.2	NP_004955.2	Q13547	HDAC1_HUMAN	histone deacetylase 1	156	Histone deacetylase.				anti-apoptosis|blood coagulation|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|histone H3 deacetylation|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of androgen receptor signaling pathway|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytosol|NuRD complex|Sin3 complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|identical protein binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|RNA polymerase II transcription corepressor activity|sequence-specific DNA binding transcription factor activity	p.I156I(1)		NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	18		Breast(348;0.000523)|Lung NSC(340;0.000992)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Lung SC(1967;0.113)		KIRC - Kidney renal clear cell carcinoma(1967;0.138)	Vorinostat(DB02546)	TCAATGATATCGTCTTGGCCA	0.532000													23	33					0	0	1	0	0
FMNL1	752	broad.mit.edu	37	17	43323270	43323270	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:43323270G>A	ENST00000331495.3	+	24	3356	c.3020G>A	c.(3019-3021)tGg>tAg	p.W1007*	CTD-2020K17.4_ENST00000420431.2_RNA|FMNL1_ENST00000587489.1_Nonsense_Mutation_p.W585*|FMNL1_ENST00000328118.3_Nonsense_Mutation_p.W1007*	NM_005892.3	NP_005883.2	O95466	FMNL_HUMAN	formin-like 1	1007	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(12)|pancreas(1)|skin(1)|urinary_tract(2)	33						GTGGAACAGTGGAAAAAAGAA	0.627000													8	12					0	0	1	0	0
AGAP3	116988	broad.mit.edu	37	7	150839049	150839049	+	Silent	SNP	T	T	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:150839049T>C	ENST00000397238.2	+	14	1869	c.1869T>C	c.(1867-1869)gcT>gcC	p.A623A	AGAP3_ENST00000463381.1_Silent_p.A292A	NM_031946.4	NP_114152.3	Q96P47	AGAP3_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	587					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|liver(2)|lung(9)|ovary(2)|prostate(3)|urinary_tract(1)	28						ACTTCGAGGCTTCAACGGCGG	0.612000													34	43					0	0	1	0	0
ZNF384	171017	broad.mit.edu	37	12	6776966	6776966	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:6776966G>A	ENST00000396795.1	-	9	1962	c.1465C>T	c.(1465-1467)Ccg>Tcg	p.P489S	ZNF384_ENST00000361959.3_Missense_Mutation_p.P550S|ZNF384_ENST00000355772.4_Missense_Mutation_p.P434S|ZNF384_ENST00000319770.3_Missense_Mutation_p.P473S|ZNF384_ENST00000396799.2_Missense_Mutation_p.P489S|ZNF384_ENST00000396801.3_Missense_Mutation_p.P550S|RP4-761J14.8_ENST00000589924.1_RNA			Q8TF68	ZN384_HUMAN	zinc finger protein 384	550	Ala-rich.|Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/ZNF384(4)	breast(3)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(1)	18						GTCTTATACGGGGTCAGGTCA	0.622000			T	"""EWSR1, TAF15 """	ALL								51	72					0	0	1	0	0
GPR115	221393	broad.mit.edu	37	6	47682527	47682527	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:47682527G>A	ENST00000283303.2	+	6	1804	c.1546G>A	c.(1546-1548)Gtc>Atc	p.V516I	GPR115_ENST00000327753.3_Missense_Mutation_p.V516I|GPR115_ENST00000371220.1_Missense_Mutation_p.V573I	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	516					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						CCGAATGATGGTCATTGGCTT	0.448000													45	61					0	0	1	0	0
WDR86	349136	broad.mit.edu	37	7	151097258	151097258	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:151097258G>A	ENST00000334493.6	-	2	663	c.233C>T	c.(232-234)aCc>aTc	p.T78I	WDR86_ENST00000477459.1_5'UTR|WDR86_ENST00000469830.2_Missense_Mutation_p.T78I	NM_198285.2	NP_938026.2	Q86TI4	WDR86_HUMAN	WD repeat domain 86	78										breast(1)|endometrium(2)|kidney(1)|lung(6)	10			OV - Ovarian serous cystadenocarcinoma(82;0.00419)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCTCCTGATGGTGCAGTCGGC	0.612000													9	8					0	0	1	0	0
SLC35G5	83650	broad.mit.edu	37	8	11189032	11189032	+	Silent	SNP	C	C	T	rs145037786		TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:11189032C>T	ENST00000382435.4	+	1	636	c.417C>T	c.(415-417)acC>acT	p.T139T		NM_054028.1	NP_473369.1	Q96KT7	AMCL2_HUMAN	solute carrier family 35, member G5	139	DUF6 1.					integral to membrane											GTTCTTCCACCGTATGCTCCG	0.577000													46	74					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33141173	33141173	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:33141173G>A	ENST00000341947.2	-	37	2915	c.2688C>T	c.(2686-2688)ccC>ccT	p.P896P	COL11A2_ENST00000374714.1_Silent_p.P870P|COL11A2_ENST00000374708.4_Silent_p.P810P|COL11A2_ENST00000395197.1_Silent_p.P836P|COL11A2_ENST00000361917.1_Silent_p.P789P|COL11A2_ENST00000374712.1_Silent_p.P815P|COL11A2_ENST00000477772.1_Intron|COL11A2_ENST00000374713.1_Silent_p.P849P|COL11A2_ENST00000357486.1_Silent_p.P875P	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	896	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						CCTTCCCAGGGGGGCCCTGGA	0.592000													16	17					0	0	1	0	0
CCDC81	60494	broad.mit.edu	37	11	86119209	86119209	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:86119209C>T	ENST00000445632.2	+	9	1282	c.1010C>T	c.(1009-1011)tCc>tTc	p.S337F	CCDC81_ENST00000528728.1_Intron|CCDC81_ENST00000354755.1_Missense_Mutation_p.S247F|CCDC81_ENST00000278487.3_Intron	NM_001156474.1	NP_001149946.1	Q6ZN84	CCD81_HUMAN	coiled-coil domain containing 81	337										kidney(3)|large_intestine(8)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	20		Acute lymphoblastic leukemia(157;5.51e-06)|all_hematologic(158;0.00535)				CAACGAAATTCCCTGTTGTAC	0.388000													18	13					0	0	1	0	0
ZNF766	90321	broad.mit.edu	37	19	52793939	52793939	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:52793939C>T	ENST00000439461.1	+	4	938	c.895C>T	c.(895-897)Cat>Tat	p.H299Y	ZNF766_ENST00000359102.4_Missense_Mutation_p.H314Y|ZNF766_ENST00000599581.1_3'UTR|CTD-2525I3.5_ENST00000594865.1_RNA|ZNF766_ENST00000593612.1_Missense_Mutation_p.H314Y	NM_001010851.2	NP_001010851.1	Q5HY98	ZN766_HUMAN	zinc finger protein 766	299					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)	17				GBM - Glioblastoma multiforme(134;0.00236)|OV - Ovarian serous cystadenocarcinoma(262;0.00871)		AGAGAAACCTCATAAATGTAA	0.358000													11	10					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2020446	2020446	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:2020446C>T	ENST00000262113.4	+	9	956	c.815C>T	c.(814-816)cCg>cTg	p.P272L	MYOM2_ENST00000523438.1_Intron	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	272	Ig-like C2-type 2.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		TCGATGATTCCGTACACGCAC	0.582000													25	18					0	0	1	0	0
PQLC2	54896	broad.mit.edu	37	1	19651187	19651187	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:19651187C>T	ENST00000375153.3	+	3	865	c.225C>T	c.(223-225)ctC>ctT	p.L75L	PQLC2_ENST00000400548.2_Silent_p.L10L|PQLC2_ENST00000375155.3_Silent_p.L75L	NM_001040125.1	NP_001035214.1	Q6ZP29	PQLC2_HUMAN	PQ loop repeat containing 2	75	PQ-loop 1.					integral to membrane				haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|skin(1)|urinary_tract(1)	10		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;1.89e-05)|Kidney(64;0.000177)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TGTGGTTCCTCCTGGGCTGGA	0.622000													26	29					0	0	1	0	0
PDE7B	27115	broad.mit.edu	37	6	136500161	136500161	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:136500161C>T	ENST00000308191.6	+	10	1133	c.830C>T	c.(829-831)tCc>tTc	p.S277F	RP13-143G15.4_ENST00000417643.1_RNA|RP13-143G15.4_ENST00000591521.1_RNA|RP13-143G15.4_ENST00000585946.1_RNA	NM_018945.3	NP_061818.1	Q9NP56	PDE7B_HUMAN	phosphodiesterase 7B	277	Catalytic (By similarity).				signal transduction|synaptic transmission	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Colorectal(23;0.24)			OV - Ovarian serous cystadenocarcinoma(155;0.0136)|GBM - Glioblastoma multiforme(68;0.0147)	Dyphylline(DB00651)|Ketotifen(DB00920)	CAGCTGGGCTCCTTGATCTTG	0.418000													36	69					0	0	1	0	0
CD2	914	broad.mit.edu	37	1	117297376	117297376	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:117297376C>A	ENST00000369478.3	+	2	293	c.185C>A	c.(184-186)aCt>aAt	p.T62N	CD2_ENST00000369477.1_Missense_Mutation_p.T62N	NM_001767.3	NP_001758.2	P06729	CD2_HUMAN	CD2 molecule	62	Ig-like V-type.|LFA-3 (CD58) binding region 1.				blood coagulation|cell surface receptor linked signaling pathway|cell-cell adhesion|induction of apoptosis|leukocyte migration|membrane raft polarization|natural killer cell activation|positive regulation of myeloid dendritic cell activation|regulation of T cell differentiation|T cell activation	integral to plasma membrane	receptor activity			NS(1)|breast(2)|large_intestine(3)|liver(1)|lung(8)|skin(2)|stomach(1)	18	Lung SC(450;0.225)	all_cancers(81;3.15e-06)|Acute lymphoblastic leukemia(138;1.7e-08)|all_epithelial(167;8.38e-07)|all_lung(203;3.37e-06)|Lung NSC(69;2.31e-05)		Epithelial(280;6.71e-26)|OV - Ovarian serous cystadenocarcinoma(397;4.74e-24)|all cancers(265;1.93e-22)|Lung(183;0.0543)|Kidney(133;0.0813)|Colorectal(144;0.174)|KIRC - Kidney renal clear cell carcinoma(1967;0.176)|LUSC - Lung squamous cell carcinoma(189;0.189)|BRCA - Breast invasive adenocarcinoma(282;0.201)	Alefacept(DB00092)	TGGGAAAAAACTTCAGACAAG	0.343000													16	11					2.23348e-06	2.25494e-06	1	1	0
PRKCE	5581	broad.mit.edu	37	2	46234780	46234780	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:46234780G>A	ENST00000306156.3	+	9	1570	c.1243G>A	c.(1243-1245)Ggc>Agc	p.G415S	PRKCE_ENST00000394874.1_Missense_Mutation_p.G138S	NM_005400.2	NP_005391.1	Q02156	KPCE_HUMAN	protein kinase C, epsilon	415	Protein kinase.				activation of phospholipase C activity|induction of apoptosis|intracellular signal transduction|nerve growth factor receptor signaling pathway|platelet activation	cytosol|endoplasmic reticulum|plasma membrane	ATP binding|enzyme activator activity|metal ion binding|signal transducer activity		MBOAT2/PRKCE(2)	breast(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(13)|ovary(3)|upper_aerodigestive_tract(2)	34		all_hematologic(82;0.155)|Acute lymphoblastic leukemia(82;0.209)	LUSC - Lung squamous cell carcinoma(58;0.171)			CAAGGTGTTGGGCAAAGGCAG	0.537000													10	16					0	0	1	0	0
TACR3	6870	broad.mit.edu	37	4	104640289	104640289	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:104640289C>T	ENST00000304883.2	-	1	684	c.544G>A	c.(544-546)Gac>Aac	p.D182N		NM_001059.2	NP_001050.1	P29371	NK3R_HUMAN	tachykinin receptor 3	182						integral to plasma membrane	tachykinin receptor activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		CCTCACCTGTCCACCGCAATG	0.512000													10	8					0	0	1	0	0
MMP3	4314	broad.mit.edu	37	11	102713427	102713427	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:102713427C>T	ENST00000299855.5	-	2	582	c.326G>A	c.(325-327)tGg>tAg	p.W109*		NM_002422.3	NP_002413.1	P08254	MMP3_HUMAN	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	109					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	GGTTTTCCTCCACTTCGGGAT	0.468000													12	33					0	0	1	0	0
GRIK3	2899	broad.mit.edu	37	1	37282857	37282857	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:37282857G>A	ENST00000373091.3	-	13	1911	c.1895C>T	c.(1894-1896)gCc>gTc	p.A632V	GRIK3_ENST00000373093.4_Missense_Mutation_p.A632V	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	632					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	TGTGGACAGGGCTTTGGGCAT	0.562000													19	16					0	0	1	0	0
CA3	761	broad.mit.edu	37	8	86354322	86354322	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:86354322C>T	ENST00000285381.2	+	3	336	c.253C>T	c.(253-255)Cct>Tct	p.P85S	RP11-317J10.2_ENST00000517697.1_RNA|RP11-317J10.2_ENST00000521761.1_RNA	NM_005181.3	NP_005172.1	P07451	CAH3_HUMAN	carbonic anhydrase III, muscle specific	85					one-carbon metabolic process	cytoplasm	carbonate dehydratase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						GGGTCCTCTCCCTGGACCCTA	0.507000													40	72					0	0	1	0	0
EFCAB7	84455	broad.mit.edu	37	1	64027419	64027419	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:64027419G>A	ENST00000371088.4	+	11	1634	c.1388G>A	c.(1387-1389)gGa>gAa	p.G463E	EFCAB7_ENST00000461039.1_3'UTR	NM_032437.2	NP_115813.2	A8K855	EFCB7_HUMAN	EF-hand calcium binding domain 7	463							calcium ion binding			breast(1)|endometrium(4)|large_intestine(4)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	19						ACAAGACAAGGATTTATGGAT	0.313000													11	21					0	0	1	0	0
SLC6A20	54716	broad.mit.edu	37	3	45807058	45807058	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:45807058G>A	ENST00000358525.4	-	8	1389	c.1274C>T	c.(1273-1275)tCc>tTc	p.S425F	SLC6A20_ENST00000353278.4_Missense_Mutation_p.S388F|SLC6A20_ENST00000456124.2_Missense_Mutation_p.S425F|SLC6A20_ENST00000493980.1_5'UTR	NM_020208.3	NP_064593.1	Q9NP91	S6A20_HUMAN	solute carrier family 6 (proline IMINO transporter), member 20	425					cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(1)|large_intestine(6)|ovary(2)|skin(2)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		CAGGTGGCTGGAGATGATCTT	0.632000													4	11					0	0	1	0	0
HTR1A	3350	broad.mit.edu	37	5	63256794	63256794	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:63256794C>T	ENST00000323865.3	-	1	986	c.753G>A	c.(751-753)aaG>aaA	p.K251K	RP11-158J3.2_ENST00000502882.1_RNA	NM_000524.3	NP_000515.2	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	251					behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(29)|ovary(2)|pancreas(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	56		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	TCACACTCTTCTTGGGCTGCG	0.642000													22	34					0	0	1	0	0
CEBPE	1053	broad.mit.edu	37	14	23586998	23586998	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:23586998G>A	ENST00000206513.5	-	2	1068	c.544C>T	c.(544-546)Ccc>Tcc	p.P182S		NM_001805.3	NP_001796.2	Q15744	CEBPE_HUMAN	CCAAT/enhancer binding protein (C/EBP), epsilon	182						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(1)	9	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0064)		TTCAGGAGGGGACTGCAGGGG	0.677000													26	22					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85383098	85383098	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:85383098C>T	ENST00000258888.5	+	5	1361	c.1194C>T	c.(1192-1194)atC>atT	p.I398I		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	398					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TGCGCGAGATCGAGCAGAGCT	0.642000													5	38					0	0	1	0	0
APEH	327	broad.mit.edu	37	3	49714354	49714354	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:49714354C>T	ENST00000296456.5	+	10	1296	c.896C>T	c.(895-897)tCc>tTc	p.S299F	APEH_ENST00000438011.1_Missense_Mutation_p.S299F	NM_001640.3	NP_001631.3	P13798	ACPH_HUMAN	acylaminoacyl-peptide hydrolase	299					proteolysis	cytoplasm|nuclear membrane	serine-type endopeptidase activity			endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|skin(1)|stomach(2)|urinary_tract(1)	15				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TCGGATGACTCCCTGGCTGTC	0.587000													20	39					0	0	1	0	0
RARRES2	5919	broad.mit.edu	37	7	150037535	150037535	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:150037535G>A	ENST00000466675.1	-	1	1197	c.164C>T	c.(163-165)gCc>gTc	p.A55V	RARRES2_ENST00000223271.3_Missense_Mutation_p.A55V|RARRES2_ENST00000482669.1_Missense_Mutation_p.A55V			Q99969	RARR2_HUMAN	retinoic acid receptor responder (tazarotene induced) 2	55					embryonic digestive tract development|in utero embryonic development|positive regulation of macrophage chemotaxis|retinoid metabolic process	extracellular matrix	receptor binding			endometrium(1)|large_intestine(1)|lung(1)|pancreas(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(82;0.011)			CGTGTCCACGGCGCTCTCCAC	0.677000													3	9					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189871685	189871685	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:189871685C>G	ENST00000304636.3	+	44	3394	c.3224C>G	c.(3223-3225)gCt>gGt	p.A1075G	COL3A1_ENST00000317840.5_Intron	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	1075	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CCTGCTGGTGCTCCCGGTCCT	0.398000													13	22					0	0	1	0	0
LINGO2	158038	broad.mit.edu	37	9	27949488	27949488	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:27949488C>T	ENST00000379992.2	-	6	1631	c.1182G>A	c.(1180-1182)aaG>aaA	p.K394K	LINGO2_ENST00000308675.3_Silent_p.K394K	NM_152570.2	NP_689783.1	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	394	LRRCT.					integral to membrane				autonomic_ganglia(1)|breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	44	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		TATGGAAATCCTTGAAAGACC	0.507000													15	36					0	0	1	0	0
ARL9	132946	broad.mit.edu	37	4	57389908	57389908	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:57389908G>T	ENST00000360096.2	+	4	552	c.238G>T	c.(238-240)Gca>Tca	p.A80S		NM_206919.1	NP_996802.1	Q6T311	ARL9_HUMAN	ADP-ribosylation factor-like 9	144							GTP binding			lung(2)	2	Glioma(25;0.08)|all_neural(26;0.101)					TGAAGCTTTGGCATTATCTGA	0.418000													8	9					1.12685e-05	1.13668e-05	1	1	0
PPP1R3A	5506	broad.mit.edu	37	7	113520130	113520130	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:113520130C>T	ENST00000284601.3	-	4	1085	c.1017G>A	c.(1015-1017)agG>agA	p.R339R		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	339					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						AAAATGTATTCCTTTCATCTC	0.328000													16	52					0	0	1	0	0
SLC5A12	159963	broad.mit.edu	37	11	26692740	26692740	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:26692740C>T	ENST00000396005.3	-	15	2075	c.1766G>A	c.(1765-1767)gGa>gAa	p.G589E		NM_178498.3	NP_848593.2	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12	589					sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)	35						TCTTCTGAGTCCGTTCTGTAA	0.438000													12	45					0	0	1	0	0
DSE	29940	broad.mit.edu	37	6	116756962	116756962	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:116756962G>A	ENST00000331677.3	+	7	1775	c.1331G>A	c.(1330-1332)aGa>aAa	p.R444K	DSE_ENST00000359564.2_Missense_Mutation_p.R444K|DSE_ENST00000537543.1_Missense_Mutation_p.R463K|DSE_ENST00000452085.3_Missense_Mutation_p.R444K			Q9UL01	DSE_HUMAN	dermatan sulfate epimerase	444					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		AAAGGATGGAGAAATTTTAAT	0.408000													15	17					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15256193	15256193	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:15256193G>A	ENST00000378116.4	-	8	1400	c.1394C>T	c.(1393-1395)cCc>cTc	p.P465L	FAM171A1_ENST00000477161.1_5'UTR	NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	465			P -> S (in dbSNP:rs3814165).			integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						TGCCTTTAAGGGAAAAACCTC	0.463000													12	20					0	0	1	0	0
ACSF2	80221	broad.mit.edu	37	17	48548427	48548427	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:48548427C>T	ENST00000427954.2	+	12	1372	c.1329C>T	c.(1327-1329)ttC>ttT	p.F443F	ACSF2_ENST00000506085.1_3'UTR|ACSF2_ENST00000541920.1_Silent_p.F258F|ACSF2_ENST00000502667.1_Silent_p.F405F|ACSF2_ENST00000504392.1_Silent_p.F375F|ACSF2_ENST00000300441.4_Silent_p.F418F			Q96CM8	ACSF2_HUMAN	acyl-CoA synthetase family member 2	418					fatty acid metabolic process	mitochondrion	ATP binding|ligase activity			endometrium(7)|kidney(3)|large_intestine(1)|lung(1)|stomach(1)	13	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			CCGTGACATTCGCGCACTTCC	0.557000													11	28					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87173553	87173553	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:87173553C>T	ENST00000265724.3	-	18	2520	c.2103G>A	c.(2101-2103)atG>atA	p.M701I	ABCB1_ENST00000543898.1_Missense_Mutation_p.M637I	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	701					G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	AATTTAGCTTCATAATCCTCC	0.313000													34	29					0	0	1	0	0
TBC1D9	23158	broad.mit.edu	37	4	141622684	141622684	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:141622684G>A	ENST00000442267.2	-	2	289	c.215C>T	c.(214-216)tCc>tTc	p.S72F		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	72						intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				GTAGACCAGGGAGTCTGGAGT	0.498000													6	13					0	0	1	0	0
SH3TC1	54436	broad.mit.edu	37	4	8229539	8229539	+	Silent	SNP	C	C	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:8229539C>G	ENST00000539824.1	+	12	2264	c.1890C>G	c.(1888-1890)ctC>ctG	p.L630L	SH3TC1_ENST00000245105.3_Silent_p.L706L			Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	706							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						CCGCGTGGCTCTCAGACTGCT	0.652000													15	28					0	0	1	0	0
INS-IGF2	723961	broad.mit.edu	37	11	2182069	2182069	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:2182069C>T	ENST00000397270.1	-	2	191	c.133G>A	c.(133-135)Gaa>Aaa	p.E45K	INS_ENST00000512523.1_Missense_Mutation_p.E45K|INS_ENST00000381330.4_Missense_Mutation_p.E45K|INS_ENST00000250971.3_Missense_Mutation_p.E45K|INS_ENST00000397262.1_Missense_Mutation_p.E45K	NM_001042376.2	NP_001035835.1	Q1WM24	Q1WM24_HUMAN		45					glucose metabolic process	extracellular region	hormone activity			haematopoietic_and_lymphoid_tissue(1)|lung(3)|prostate(1)	5		all_epithelial(84;0.00018)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;0.00256)|LUSC - Lung squamous cell carcinoma(625;0.0832)|Lung(200;0.156)		AAGCCTCGTTCCCCGCACACT	0.667000													20	20					0	0	1	0	0
EPB41L5	57669	broad.mit.edu	37	2	120847962	120847962	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:120847962C>T	ENST00000263713.5	+	12	1127	c.913C>T	c.(913-915)Cat>Tat	p.H305Y	EPB41L5_ENST00000331393.4_Missense_Mutation_p.H305Y|EPB41L5_ENST00000443124.1_Missense_Mutation_p.H305Y|EPB41L5_ENST00000443902.2_Missense_Mutation_p.H305Y|EPB41L5_ENST00000452780.1_Missense_Mutation_p.H305Y	NM_020909.3	NP_065960.2	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	305	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(12)|ovary(1)	26						TAGACTGGATCATCCAAAAGC	0.388000													37	40					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110455983	110455983	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:110455983C>T	ENST00000378402.5	+	37	4747	c.4643C>T	c.(4642-4644)aCc>aTc	p.T1548I		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1548					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CTGAACAATACCAGGGTTAAA	0.433000										HNSCC(38;0.096)			5	35					0	0	1	0	0
KGFLP2	654466	broad.mit.edu	37	9	41962602	41962602	+	RNA	SNP	G	G	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:41962602G>T	ENST00000454645.1	-	0	902					NR_003670.1																						TTCTTTCTTTGTTTTTTTTCC	0.373000													5	17					0.27861	0.278852	1	1	0
KRT39	390792	broad.mit.edu	37	17	39116727	39116727	+	Silent	SNP	C	C	T	rs138568359		TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:39116727C>T	ENST00000355612.2	-	6	1058	c.1023G>A	c.(1021-1023)acG>acA	p.T341T	AC004231.2_ENST00000418393.1_RNA	NM_213656.3	NP_998821.3	Q6A163	K1C39_HUMAN	keratin 39	341	Coil 2.|Rod.		T -> M (in dbSNP:rs17843021).			intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	17		Breast(137;0.00043)|Ovarian(249;0.15)				CCTCTGTCTCCGTTAGGATGC	0.498000													29	49					0	0	1	0	0
KANSL1	284058	broad.mit.edu	37	17	44110530	44110530	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:44110530G>A	ENST00000262419.6	-	13	3223	c.2753C>T	c.(2752-2754)gCc>gTc	p.A918V	KANSL1_ENST00000575318.1_Missense_Mutation_p.A854V|KANSL1_ENST00000574590.1_Missense_Mutation_p.A918V|KANSL1_ENST00000572904.1_Missense_Mutation_p.A918V|KANSL1_ENST00000393476.3_Missense_Mutation_p.A212V|KANSL1_ENST00000432791.1_Missense_Mutation_p.A918V	NM_001193466.1	NP_001180395.1	Q7Z3B3	K1267_HUMAN	KAT8 regulatory NSL complex subunit 1	918						MLL1 complex	protein binding										ATGCAGGGCGGCGAAGGCTGC	0.597000													3	2					0	0	1	0	0
IGKV2D-24	28885	broad.mit.edu	37	2	90044168	90044168	+	RNA	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:90044168C>T	ENST00000462693.1	+	0	119																											ACTCCACTCTCCTCGCCTGTC	0.463000													33	42					0	0	1	0	0
HRG	3273	broad.mit.edu	37	3	186395415	186395415	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:186395415C>T	ENST00000232003.4	+	7	1401	c.1321C>T	c.(1321-1323)Cga>Tga	p.R441*		NM_000412.2	NP_000403.1	P04196	HRG_HUMAN	histidine-rich glycoprotein	441	His/Pro-rich (HRR).				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(12)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		CTTAAGAAGGCGAGGCCCAGG	0.552000													17	27					0	0	1	0	0
TNRC6B	23112	broad.mit.edu	37	22	40662432	40662432	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr22:40662432G>A	ENST00000454349.2	+	5	2409	c.2198G>A	c.(2197-2199)gGa>gAa	p.G733E	TNRC6B_ENST00000402203.1_Intron|TNRC6B_ENST00000301923.9_Intron|TNRC6B_ENST00000335727.8_Missense_Mutation_p.G733E	NM_001162501.1	NP_001155973.1	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B	733					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding			breast(1)	1						CAGGGGTGGGGAGGTGGACGC	0.502000													4	7					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60907443	60907443	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:60907443C>T	ENST00000252999.3	-	28	3603	c.3537G>A	c.(3535-3537)caG>caA	p.Q1179Q		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	1179	Domain IV 1 (domain IV B).				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGAAGCGTGCCTGTTCGGCTG	0.617000													25	26					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178413186	178413186	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:178413186G>A	ENST00000231188.5	-	8	2247	c.2069C>T	c.(2068-2070)cCc>cTc	p.P690L	RP11-281O15.4_ENST00000519491.1_RNA|GRM6_ENST00000517717.1_Missense_Mutation_p.P690L	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	690					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		GCTGATGAAGGGAGGGGGTGT	0.642000													4	7					0	0	1	0	0
AMOTL2	51421	broad.mit.edu	37	3	134089877	134089877	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:134089877G>A	ENST00000514516.1	-	2	751	c.573C>T	c.(571-573)ccC>ccT	p.P191P	AMOTL2_ENST00000422605.2_Silent_p.P133P|AMOTL2_ENST00000249883.5_Silent_p.P133P|AMOTL2_ENST00000511759.1_Intron|AMOTL2_ENST00000513145.1_Silent_p.P133P	NM_001278683.1	NP_001265612.1	Q9Y2J4	AMOL2_HUMAN	angiomotin like 2	133										endometrium(8)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	19						GGGCCCCACGGGGATCTCGGT	0.687000													6	9					0	0	1	0	0
CLDN9	9080	broad.mit.edu	37	16	3063828	3063828	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr16:3063828C>T	ENST00000445369.2	+	1	1372	c.465C>T	c.(463-465)gcC>gcT	p.A155A		NM_020982.3	NP_066192.1	O95484	CLD9_HUMAN	claudin 9	155					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(2)|large_intestine(1)|lung(5)|prostate(2)	10						TGGCTGAGGCCCTCAAGCGGG	0.701000													23	23					0	0	1	0	0
OR6X1	390260	broad.mit.edu	37	11	123624373	123624373	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:123624373G>A	ENST00000327930.2	-	1	880	c.854C>T	c.(853-855)cCc>cTc	p.P285L		NM_001005188.1	NP_001005188.1	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X, member 1	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)	23		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		ATAAATAAAGGGATTCAGAAG	0.423000													26	49					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78947495	78947495	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:78947495G>A	ENST00000545128.1	+	33	5174	c.4636G>A	c.(4636-4638)Gga>Aga	p.G1546R		NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	714					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						GTTCCAGCTAGGAAAAGAGTG	0.537000													10	0					0	0	1	0	0
BCL3	602	broad.mit.edu	37	19	45260646	45260646	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:45260646G>C	ENST00000164227.5	+	5	1031	c.787G>C	c.(787-789)Gag>Cag	p.E263Q		NM_005178.4	NP_005169.2	P20749	BCL3_HUMAN	B-cell CLL/lymphoma 3	263					DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|I-kappaB kinase/NF-kappaB cascade|maintenance of protein location in nucleus|negative regulation of apoptosis|negative regulation of interleukin-8 biosynthetic process|negative regulation of transcription, DNA-dependent|positive regulation of translation|protein import into nucleus, translocation|regulation of DNA binding|regulation of NF-kappaB import into nucleus|response to UV-C|response to virus	Bcl3-Bcl10 complex|Bcl3/NF-kappaB2 complex|nucleus|perinuclear region of cytoplasm	protein binding, bridging|transcription factor binding	p.E255Q(1)		kidney(1)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	Lung NSC(12;0.000698)|all_lung(12;0.002)	Ovarian(192;0.0728)				GCTCTTGCTAGAGCGCGGTGC	0.687000			T	IGH@	CLL								7	9					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86469011	86469011	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:86469011C>T	ENST00000361669.2	+	4	3280	c.2181C>T	c.(2179-2181)atC>atT	p.I727I	GRM3_ENST00000546348.1_Silent_p.I319I|GRM3_ENST00000394720.2_Intron|GRM3_ENST00000439827.1_Intron|GRM3_ENST00000536043.1_Silent_p.I599I	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	727					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	AAACAGTCATCCTAAAATGCA	0.493000													13	36					0	0	1	0	0
CYBA	1535	broad.mit.edu	37	16	88713210	88713210	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr16:88713210G>A	ENST00000569359.1	-	4	256	c.240C>T	c.(238-240)ttC>ttT	p.F80F	CYBA_ENST00000261623.3_Silent_p.F80F|CYBA_ENST00000567174.1_Silent_p.F80F			P13498	CY24A_HUMAN	cytochrome b-245, alpha polypeptide	80					cytochrome complex assembly|electron transport chain|hydrogen peroxide biosynthetic process|inflammatory response|innate immune response|respiratory burst|smooth muscle hypertrophy|superoxide anion generation|transport	NADPH oxidase complex|stored secretory granule	electron carrier activity|heme binding|protein heterodimerization activity|SH3 domain binding			endometrium(1)|liver(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0478)		TAAAGGGCCCGAACAGCTTCA	0.652000													21	10					0	0	1	0	0
SKP1	6500	broad.mit.edu	37	5	133496736	133496736	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:133496736G>A	ENST00000353411.6	-	4	440	c.257C>T	c.(256-258)cCt>cTt	p.P86L	SKP1_ENST00000522855.1_Missense_Mutation_p.P86L|SKP1_ENST00000522552.1_Missense_Mutation_p.P86L|SKP1_ENST00000517625.1_Missense_Mutation_p.P86L|SKP1_ENST00000521216.1_Missense_Mutation_p.P86L	NM_170679.2	NP_733779.1	P63208	SKP1_HUMAN	S-phase kinase-associated protein 1	86					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|G1/S transition of mitotic cell cycle|histone H2A monoubiquitination|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|viral reproduction	cytosol|nucleoplasm|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GTCCCAAACAGGGATATCATC	0.418000													10	9					0	0	1	0	0
DPP10	57628	broad.mit.edu	37	2	116525977	116525977	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:116525977C>T	ENST00000410059.1	+	13	1698	c.1218C>T	c.(1216-1218)atC>atT	p.I406I	DPP10_ENST00000409163.1_Silent_p.I356I|DPP10_ENST00000310323.8_Silent_p.I399I|DPP10_ENST00000393147.2_Silent_p.I410I	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919.2	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	406					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						TGTTCCTCATCCAGGTAAGTG	0.473000													15	10					0	0	1	0	0
ELFN2	114794	broad.mit.edu	37	22	37769436	37769436	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr22:37769436G>A	ENST00000402918.1	-	3	2924	c.2139C>T	c.(2137-2139)ccC>ccT	p.P713P	ELFN2_ENST00000349653.3_Silent_p.P713P|RP1-63G5.5_ENST00000430883.1_RNA	NM_052906.3	NP_443138.2	Q5R3F8	LRFN6_HUMAN	extracellular leucine-rich repeat and fibronectin type III domain containing 2	713						cell surface|integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	35	Melanoma(58;0.0574)					AGTACAGGGCGGGAAAGCTGT	0.706000													4	8					0	0	1	0	0
STAP2	55620	broad.mit.edu	37	19	4325490	4325490	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:4325490C>T	ENST00000600324.1	-	10	949	c.882G>A	c.(880-882)caG>caA	p.Q294Q	STAP2_ENST00000594605.1_Silent_p.Q294Q|STAP2_ENST00000597593.1_5'UTR	NM_017720.2	NP_060190.2	Q9UGK3	STAP2_HUMAN	signal transducing adaptor family member 2	294	Pro-rich.					cytoplasm|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		GCAGCTTGTCCTGGCTAGACG	0.587000													80	106					0	0	1	0	0
EGR4	1961	broad.mit.edu	37	2	73518837	73518837	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:73518837G>A	ENST00000545030.1	-	2	1592	c.1518C>T	c.(1516-1518)atC>atT	p.I506I	EGR4_ENST00000436467.2_Silent_p.I403I	NM_001965.3	NP_001956.3	B7ZKU3	B7ZKU3_HUMAN	early growth response 4	402						intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						GGCCCGTGTGGATGCGCAGGT	0.677000													18	32					0	0	1	0	0
PTPRJ	5795	broad.mit.edu	37	11	48166409	48166409	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:48166409G>T	ENST00000418331.2	+	13	3110	c.2758G>T	c.(2758-2760)Ggg>Tgg	p.G920W		NM_002843.3	NP_002834.3	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	920				YNGKLEPLGSYR -> LQWEAGTSGLLP (in Ref. 2; BAA07035).	contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|endometrium(7)|kidney(7)|large_intestine(5)|lung(15)|ovary(1)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						TTATTACAATGGGAAGCTGGA	0.458000													20	53					1.55795e-14	1.59098e-14	1	1	0
DSC1	1823	broad.mit.edu	37	18	28737418	28737418	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr18:28737418C>T	ENST00000257197.3	-	3	528	c.267G>A	c.(265-267)agG>agA	p.R89R	RP11-408H20.2_ENST00000581836.1_RNA|DSC1_ENST00000257198.5_Silent_p.R89R	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	89					homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			AAAAACTTTTCCTTTCAGAAG	0.428000													10	13					0	0	1	0	0
SLC1A6	6511	broad.mit.edu	37	19	15063833	15063833	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:15063833G>A	ENST00000430939.2	-	8	1343	c.1214C>T	c.(1213-1215)cCc>cTc	p.P405L	SLC1A6_ENST00000600144.1_Missense_Mutation_p.P391L|SLC1A6_ENST00000221742.3_Missense_Mutation_p.P469L			P48664	EAA4_HUMAN	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	469					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(8)|liver(1)|lung(12)|ovary(3)|pancreas(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42					L-Glutamic Acid(DB00142)	ACCCGCCTGGGGGATGCCAGC	0.607000													73	115					0	0	1	0	0
SOX17	64321	broad.mit.edu	37	8	55372442	55372442	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:55372442C>T	ENST00000297316.4	+	2	1336	c.1132C>T	c.(1132-1134)Ccc>Tcc	p.P378S		NM_022454.3	NP_071899.1	Q9H6I2	SOX17_HUMAN	SRY (sex determining region Y)-box 17	378	Sox C-terminal.				angiogenesis|cardiac cell fate determination|endocardial cell differentiation|endocardium formation|endoderm formation|heart formation|heart looping|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|outflow tract morphogenesis|positive regulation of transcription, DNA-dependent|protein destabilization|protein stabilization|regulation of embryonic development|renal system development|vasculogenesis|Wnt receptor signaling pathway	transcription factor complex	beta-catenin binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			endometrium(6)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)	18		Lung NSC(129;0.109)|all_epithelial(80;0.176)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;1.9e-07)|Epithelial(17;1.7e-05)|all cancers(17;0.000159)			GATGGGCCTCCCCTACCAGGG	0.627000													9	29					0	0	1	0	0
CSF1R	1436	broad.mit.edu	37	5	149439417	149439417	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:149439417G>A	ENST00000286301.3	-	15	2269	c.1978C>T	c.(1978-1980)Ctg>Ttg	p.L660L	CSF1R_ENST00000515239.1_5'UTR	NM_005211.3	NP_005202.2	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor	660	Protein kinase.				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(38)|kidney(2)|large_intestine(6)|liver(3)|lung(23)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	93			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	GTGATGACCAGTACAGGGCCT	0.627000													14	26					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82580232	82580232	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:82580232C>T	ENST00000423517.2	-	6	10009	c.9672G>A	c.(9670-9672)gaG>gaA	p.E3224E	PCLO_ENST00000333891.8_Silent_p.E3224E	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3155	Gln-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GCTTAATTTTCTCCAGTTCCA	0.443000													16	47					0	0	1	0	0
WTIP	126374	broad.mit.edu	37	19	34991079	34991079	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:34991079C>T	ENST00000590071.2	+	8	1535	c.1198C>T	c.(1198-1200)Ccc>Tcc	p.P400S	WTIP_ENST00000270288.6_Missense_Mutation_p.P624S	NM_001080436.1	NP_001073905.1			Wilms tumor 1 interacting protein											NS(1)|large_intestine(2)|lung(1)	4	all_lung(56;5.94e-07)|Lung NSC(56;9.35e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			CCGTTGCTATCCCCTGGCGGG	0.657000													14	10					0	0	1	0	0
USP54	159195	broad.mit.edu	37	10	75286499	75286499	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:75286499G>A	ENST00000339859.4	-	15	2200	c.2100C>T	c.(2098-2100)tcC>tcT	p.S700S	USP54_ENST00000497106.1_5'UTR|USP54_ENST00000428547.1_Silent_p.S550S|USP54_ENST00000408019.1_Silent_p.S700S|USP54_ENST00000394811.2_5'UTR			Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	700					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(5)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)	30	Prostate(51;0.0112)					TATGACGCCAGGAAGGAACCA	0.493000													13	18					0	0	1	0	0
KCNJ11	3767	broad.mit.edu	37	11	17409022	17409022	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:17409022C>T	ENST00000339994.4	-	1	1184	c.617G>A	c.(616-618)cGc>cAc	p.R206H	KCNJ11_ENST00000528731.1_Missense_Mutation_p.R119H	NM_000525.3	NP_000516.3	B4DWI4	B4DWI4_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 11	119						integral to membrane	ATP-activated inward rectifier potassium channel activity			endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(3)|skin(2)	16				READ - Rectum adenocarcinoma(2;0.0276)|Colorectal(2;0.0633)		CATGCTCTTGCGGAGGTCACC	0.647000											OREG0020810	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	13					0	0	1	0	0
SSH1	54434	broad.mit.edu	37	12	109186434	109186434	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:109186434G>A	ENST00000326495.5	-	14	1614	c.1521C>T	c.(1519-1521)ctC>ctT	p.L507L	SSH1_ENST00000360239.3_Silent_p.L195L|SSH1_ENST00000326470.5_Silent_p.L518L|SSH1_ENST00000551165.1_Silent_p.L507L	NM_018984.3	NP_061857.3	Q8WYL5	SSH1_HUMAN	slingshot protein phosphatase 1	507					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						AACAGCAGGGGAGGGGGGGCC	0.647000													26	22					0	0	1	0	0
BRINP1	1620	broad.mit.edu	37	9	122075525	122075525	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:122075525C>T	ENST00000265922.3	-	2	570	c.109G>A	c.(109-111)Gaa>Aaa	p.E37K	DBC1_ENST00000373964.2_Missense_Mutation_p.E37K	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		37					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						CAATCAAATTCCTTGGAGACA	0.498000													13	3					0	0	1	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713681	70713681	+	RNA	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:70713681C>T	ENST00000530196.1	-	0	837					NR_003951.1																						AATACATCCTCTTGCACCTTT	0.388000													24	33					0	0	1	0	0
MSL2	55167	broad.mit.edu	37	3	135870068	135870068	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:135870068G>A	ENST00000309993.2	-	2	2387	c.1655C>T	c.(1654-1656)cCa>cTa	p.P552L	MSL2_ENST00000434835.2_Missense_Mutation_p.P478L	NM_018133.3	NP_060603.2	Q9HCI7	MSL2_HUMAN	male-specific lethal 2 homolog (Drosophila)	552					histone H4-K16 acetylation	MSL complex	zinc ion binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	18						CGTCGTTACTGGGGACCCTGT	0.448000													33	49					0	0	1	0	0
MYO3B	140469	broad.mit.edu	37	2	171243659	171243659	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:171243659C>T	ENST00000334231.6	+	14	1445	c.1445C>T	c.(1444-1446)tCc>tTc	p.S482F	MYO3B_ENST00000602629.1_3'UTR|MYO3B_ENST00000408978.4_Missense_Mutation_p.S473F|MYO3B_ENST00000409044.3_Missense_Mutation_p.S473F			Q8WXR4	MYO3B_HUMAN	myosin IIIB	473	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						CAAGTCAACTCCCTGGTGGAA	0.443000													13	26					0	0	1	0	0
PTGDR	5729	broad.mit.edu	37	14	52735285	52735285	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:52735285G>A	ENST00000306051.2	+	1	855	c.753G>A	c.(751-753)agG>agA	p.R251R	PTGDR_ENST00000553372.1_Silent_p.R251R	NM_000953.2	NP_000944.1	Q13258	PD2R_HUMAN	prostaglandin D2 receptor (DP)	251						integral to membrane|plasma membrane	prostaglandin D receptor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Breast(41;0.0639)|all_epithelial(31;0.0887)				Nedocromil(DB00716)	CGGACGGGAGGGAAGCGTCCC	0.667000													32	52					0	0	1	0	0
SRD5A1	6715	broad.mit.edu	37	5	6662995	6662995	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:6662995C>T	ENST00000274192.5	+	4	863	c.629C>T	c.(628-630)gCc>gTc	p.A210V	SRD5A1_ENST00000537411.1_3'UTR|SRD5A1_ENST00000538824.1_Missense_Mutation_p.A163V	NM_001047.2	NP_001038.1	P18405	S5A1_HUMAN	steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)	210					androgen biosynthetic process|cell differentiation|sex determination|sex differentiation	endoplasmic reticulum membrane|integral to membrane|microsome	3-oxo-5-alpha-steroid 4-dehydrogenase activity|electron carrier activity			endometrium(3)|kidney(1)|large_intestine(1)|lung(8)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19					Dutasteride(DB01126)|Finasteride(DB01216)	TGTGGCTATGCCCTGGCCAGC	0.423000													34	33					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3205659	3205659	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:3205659C>T	ENST00000520002.1	-	23	3887	c.3332G>A	c.(3331-3333)gGa>gAa	p.G1111E	CSMD1_ENST00000542608.1_Missense_Mutation_p.G1110E|CSMD1_ENST00000537824.1_Missense_Mutation_p.G1110E|CSMD1_ENST00000539096.1_Missense_Mutation_p.G1110E|CSMD1_ENST00000602723.1_Missense_Mutation_p.G1111E|CSMD1_ENST00000400186.3_Missense_Mutation_p.G1111E|CSMD1_ENST00000602557.1_Missense_Mutation_p.G1111E			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1111	CUB 7.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TCCTTCATTTCCTTTGACACT	0.343000													8	7					0	0	1	0	0
DNER	92737	broad.mit.edu	37	2	230450605	230450605	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:230450605C>T	ENST00000341772.4	-	4	950	c.816G>A	c.(814-816)gaG>gaA	p.E272E	DNER_ENST00000482831.1_5'UTR	NM_139072.3	NP_620711.3	Q8NFT8	DNER_HUMAN	delta/notch-like EGF repeat containing	272					central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	63		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		AGGCGAGCATCTCCTCCAGGA	0.502000													7	18					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149500812	149500812	+	RNA	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:149500812G>A	ENST00000378016.2	+	0	8130							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCCAACCAGGGGGCTGCCCCC	0.692000													7	10					0	0	1	0	0
SUCLG1	8802	broad.mit.edu	37	2	84658743	84658743	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:84658743G>A	ENST00000393868.2	-	7	924	c.714C>T	c.(712-714)gaC>gaT	p.D238D	SUCLG1_ENST00000491123.1_5'UTR	NM_003849.3	NP_003840.2	P53597	SUCA_HUMAN	succinate-CoA ligase, alpha subunit	238					tricarboxylic acid cycle		ATP citrate synthase activity|GTP binding|succinate-CoA ligase (GDP-forming) activity			kidney(4)|large_intestine(4)|lung(2)	10					Succinic acid(DB00139)	TTTCGAGGCAGTCAATAAAAT	0.368000													21	23					0	0	1	0	0
WDR12	55759	broad.mit.edu	37	2	203762097	203762097	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:203762097G>A	ENST00000261015.3	-	5	1129	c.380C>T	c.(379-381)tCc>tTc	p.S127F		NM_018256.3	NP_060726.3	Q9GZL7	WDR12_HUMAN	WD repeat domain 12	127	Sufficient for nucleolar localization.				cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding			endometrium(3)|large_intestine(1)|liver(1)|lung(6)|prostate(1)|skin(1)	13						TCCTTCCAAGGACCAGATCCG	0.378000													15	32					0	0	1	0	0
SRP72	6731	broad.mit.edu	37	4	57340312	57340312	+	Silent	SNP	A	A	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:57340312A>G	ENST00000342756.5	+	4	1168	c.447A>G	c.(445-447)acA>acG	p.T149T	SRP72_ENST00000504757.1_Silent_p.T149T|SRP72_ENST00000510663.1_Silent_p.T149T	NM_006947.3	NP_008878.3	O76094	SRP72_HUMAN	signal recognition particle 72kDa	149					response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|nucleolus|plasma membrane|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|signal recognition particle binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(4)|liver(2)|lung(7)|ovary(2)	22	Glioma(25;0.08)|all_neural(26;0.101)					AGAGGAAAACAAACCTTTCAG	0.393000													16	28					0	0	1	0	0
GAB4	128954	broad.mit.edu	37	22	17488972	17488972	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr22:17488972C>T	ENST00000400588.1	-	1	140	c.33G>A	c.(31-33)gaG>gaA	p.E11E		NM_001037814.1	NP_001032903.1	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member 4	11										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(24)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44		all_epithelial(15;0.112)|Lung NSC(13;0.248)				GTGGGCACAGCTCCCGGGAGG	0.682000													5	2					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37746482	37746482	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:37746482G>A	ENST00000539465.1	+	16	5046	c.4453G>A	c.(4453-4455)Gag>Aag	p.E1485K	FRMPD1_ENST00000377765.3_Missense_Mutation_p.E1485K|RP11-613M10.9_ENST00000540557.1_Intron			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1485						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		GTCCCCCGAAGAGATGCAGGG	0.637000													15	5					0	0	1	0	0
LIFR	3977	broad.mit.edu	37	5	38512000	38512000	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:38512000G>A	ENST00000263409.4	-	6	790	c.628C>T	c.(628-630)Ccc>Tcc	p.P210S	LIFR_ENST00000453190.2_Missense_Mutation_p.P210S|LIFR_ENST00000503088.1_5'UTR	NM_002310.5	NP_002301.1	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor alpha	210					positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			NS(2)|breast(4)|endometrium(6)|kidney(2)|large_intestine(30)|liver(2)|lung(21)|ovary(3)|skin(5)|stomach(1)|urinary_tract(2)	78	all_lung(31;0.00021)					CATTCCAAGGGCATATCTGAG	0.418000			T	PLAG1	salivary adenoma								16	21					0	0	1	0	0
OR4X2	119764	broad.mit.edu	37	11	48266964	48266964	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:48266964G>A	ENST00000302329.3	+	1	357	c.309G>A	c.(307-309)gaG>gaA	p.E103E		NM_001004727.1	NP_001004727.1	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X, member 2	103					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(4)|lung(12)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	20						GTGGCACTGAGATTTTCCTGC	0.512000													26	40					0	0	1	0	0
ARSE	415	broad.mit.edu	37	X	2867709	2867709	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:2867709G>A	ENST00000545496.1	-	7	856	c.565C>T	c.(565-567)Cat>Tat	p.H189Y	ARSE_ENST00000381134.3_Missense_Mutation_p.H164Y|ARSE_ENST00000540563.1_Missense_Mutation_p.H119Y			P51690	ARSE_HUMAN	arylsulfatase E (chondrodysplasia punctata 1)	164					skeletal system development	Golgi stack	arylsulfatase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AAGCCATGATGGAGAGGGTGG	0.498000													7	16					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31809231	31809231	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:31809231C>T	ENST00000446923.2	+	7	1311	c.920C>T	c.(919-921)cCc>cTc	p.P307L	ZEB1_ENST00000559858.1_3'UTR|ZEB1_ENST00000320985.10_Missense_Mutation_p.P323L|ZEB1_ENST00000542815.3_Missense_Mutation_p.P256L|ZEB1_ENST00000361642.5_Missense_Mutation_p.P324L|ZEB1_ENST00000560721.2_Missense_Mutation_p.P303L	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	323					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				CCAGGCAGTCCCACACGACCA	0.418000													17	26					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13781007	13781007	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:13781007C>T	ENST00000265104.4	-	53	8986	c.8882G>A	c.(8881-8883)gGa>gAa	p.G2961E		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2961	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GCTCTGCTTTCCTGATCCGCC	0.463000									Kartagener syndrome				11	15					0	0	1	0	0
PTF1A	256297	broad.mit.edu	37	10	23482663	23482663	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:23482663G>A	ENST00000376504.3	+	2	1019	c.815G>A	c.(814-816)gGc>gAc	p.G272D		NM_178161.2	NP_835455.1	Q7RTS3	PTF1A_HUMAN	pancreas specific transcription factor, 1a	272					endocrine pancreas development|exocrine pancreas development|regulation of transcription, DNA-dependent|tissue development|transcription, DNA-dependent	cytoplasm|transcription factor complex				endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)|skin(1)	7						CCTGATTATGGCCTCCCTCCC	0.512000													67	119					0	0	1	0	0
TRDN	10345	broad.mit.edu	37	6	123869614	123869614	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:123869614C>T	ENST00000334268.4	-	3	693	c.376G>A	c.(376-378)Gaa>Aaa	p.E126K	TRDN_ENST00000542443.1_Missense_Mutation_p.E126K|TRDN_ENST00000398178.3_Missense_Mutation_p.E126K|TRDN_ENST00000546248.1_Missense_Mutation_p.E126K			Q13061	TRDN_HUMAN	triadin	126					muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	41				GBM - Glioblastoma multiforme(226;0.184)		TCAGTATCTTCGTCACCATCA	0.363000													3	3					0	0	1	0	0
NCAPH2	29781	broad.mit.edu	37	22	50957676	50957676	+	Missense_Mutation	SNP	A	A	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr22:50957676A>G	ENST00000395701.3	+	9	882	c.788A>G	c.(787-789)gAg>gGg	p.E263G	NCAPH2_ENST00000395698.3_Missense_Mutation_p.E263G|NCAPH2_ENST00000420993.2_Missense_Mutation_p.E263G|NCAPH2_ENST00000299821.11_Missense_Mutation_p.E263G			Q6IBW4	CNDH2_HUMAN	non-SMC condensin II complex, subunit H2	263					chromosome condensation	chromosome|nucleus				breast(1)|cervix(1)|endometrium(2)|kidney(3)|lung(10)|ovary(1)|prostate(2)|skin(3)|stomach(1)	24		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.212)		GATGCAGAGGAGGCAGTAGAG	0.667000													4	5					0	0	1	0	0
CHRDL2	25884	broad.mit.edu	37	11	74414512	74414512	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:74414512C>T	ENST00000376332.3	-	8	1280	c.784G>A	c.(784-786)Ggg>Agg	p.G262R	CHRDL2_ENST00000263671.5_Missense_Mutation_p.G262R|CHRDL2_ENST00000534159.1_5'UTR	NM_001278473.1	NP_001265402.1	Q6WN34	CRDL2_HUMAN	chordin-like 2	262	VWFC 3.				cartilage development|cell differentiation|ossification	extracellular region|mitochondrion				endometrium(1)|kidney(1)|large_intestine(6)|lung(4)|prostate(1)|skin(2)	15	Hepatocellular(1;0.098)					CACACCTCCCCGTGGGAGTAC	0.647000													6	11					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227958978	227958978	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:227958978C>T	ENST00000396625.3	-	20	1439	c.1232G>A	c.(1231-1233)gGa>gAa	p.G411E	COL4A4_ENST00000329662.7_Missense_Mutation_p.G411E	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	411	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		ACCAGGAAATCCTTGTGGCCC	0.478000													5	19					0	0	1	0	0
SERPINA5	5104	broad.mit.edu	37	14	95058453	95058453	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:95058453G>A	ENST00000329597.7	+	6	1308	c.1098G>A	c.(1096-1098)acG>acA	p.T366T	SERPINA5_ENST00000554276.1_Silent_p.T366T|SERPINA5_ENST00000553780.1_Silent_p.T366T|SERPINA3_ENST00000553947.1_5'UTR|SERPINA5_ENST00000554866.1_Silent_p.T366T	NM_000624.4	NP_000615.3	P05154	IPSP_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	366					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			endometrium(3)|large_intestine(5)|lung(18)|ovary(2)|skin(5)|upper_aerodigestive_tract(3)	36				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	CGGCAGCCACGGGGACAATAT	0.567000													81	137					0	0	1	0	0
AQP9	366	broad.mit.edu	37	15	58471453	58471453	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:58471453G>A	ENST00000219919.4	+	5	992	c.622G>A	c.(622-624)Gga>Aga	p.G208R	ALDH1A2_ENST00000558231.1_Intron|AQP9_ENST00000558772.1_Missense_Mutation_p.G143R|AQP9_ENST00000536493.1_Missense_Mutation_p.G208R	NM_020980.3	NP_066190.2	O43315	AQP9_HUMAN	aquaporin 9	208					cellular response to cAMP|excretion|immune response|metabolic process|response to mercury ion|response to osmotic stress|water homeostasis	integral to plasma membrane|intracellular membrane-bounded organelle	amine transmembrane transporter activity|carboxylic acid transmembrane transporter activity|glycerol channel activity|porin activity|purine base transmembrane transporter activity|pyrimidine base transmembrane transporter activity|water channel activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)	21				GBM - Glioblastoma multiforme(80;0.16)		TTCCTCCCTGGGACTGAACAG	0.537000													14	30					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98581897	98581897	+	Silent	SNP	C	C	T	rs56256674	byFrequency	TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:98581897C>T	ENST00000359863.4	+	60	9425	c.9216C>T	c.(9214-9216)atC>atT	p.I3072I	TRRAP_ENST00000355540.3_Silent_p.I3043I|TRRAP_ENST00000446306.3_Silent_p.I3043I	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	3072	FAT.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CTGTTCCTATCGTGGATTGCT	0.478000													47	69					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141766486	141766486	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:141766486G>A	ENST00000475668.2	+	41	4938	c.4884G>A	c.(4882-4884)acG>acA	p.T1628T	MGAM_ENST00000549489.2_Intron			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1628	Glucoamylase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	AGGCCCACACGGAGGGCGTCA	0.493000													96	50					0	0	1	0	0
SIMC1	375484	broad.mit.edu	37	5	175740715	175740715	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:175740715G>A	ENST00000443967.1	+	7	2106	c.1699G>A	c.(1699-1701)Gtc>Atc	p.V567I	SIMC1_ENST00000341199.6_Missense_Mutation_p.V152I|SIMC1_ENST00000332772.4_Missense_Mutation_p.V28I|SIMC1_ENST00000430704.2_Missense_Mutation_p.V152I					SUMO-interacting motifs containing 1																		GCCTGGGCGAGTCCTTTTCCT	0.483000													69	81					0	0	1	0	0
CCDC132	55610	broad.mit.edu	37	7	92905594	92905594	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:92905594C>T	ENST00000544910.1	+	13	1049	c.829C>T	c.(829-831)Ctg>Ttg	p.L277L	CCDC132_ENST00000305866.5_Silent_p.L307L|CCDC132_ENST00000317751.6_Silent_p.L38L|CCDC132_ENST00000535481.1_Intron|CCDC132_ENST00000541136.1_Silent_p.L118L|CCDC132_ENST00000251739.5_Silent_p.L307L	NM_001257998.1	NP_001244927.1	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132	307										endometrium(1)|large_intestine(2)|lung(5)	8	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			ATTCCAAAAGCTGCAATATAA	0.338000													30	26					0	0	1	0	0
DOCK7	85440	broad.mit.edu	37	1	62923294	62923294	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:62923294G>T	ENST00000251157.5	-	48	6295	c.6262C>A	c.(6262-6264)Cat>Aat	p.H2088N	DOCK7_ENST00000340370.5_Missense_Mutation_p.H2068N	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	2099	DHR-2.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						TTAAGGCGATGATAGTTTCTC	0.423000													56	43					2.23044e-30	2.28986e-30	1	1	0
SPHKAP	80309	broad.mit.edu	37	2	228883942	228883942	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:228883942C>T	ENST00000392056.3	-	7	1674	c.1628G>A	c.(1627-1629)gGa>gAa	p.G543E	SPHKAP_ENST00000344657.5_Missense_Mutation_p.G543E	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	543						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TTCCTTGAGTCCTTGGGGTGC	0.527000													22	46					0	0	1	0	0
TJP1	7082	broad.mit.edu	37	15	29993816	29993816	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:29993816G>A	ENST00000346128.6	-	28	5704	c.5230C>T	c.(5230-5232)Ctt>Ttt	p.L1744F	TJP1_ENST00000400011.2_Missense_Mutation_p.L1688F|TJP1_ENST00000545208.2_Missense_Mutation_p.L1664F|TJP1_ENST00000356107.6_Missense_Mutation_p.L1764F	NM_003257.3|NM_175610.2	NP_003248.3|NP_783297.2	Q07157	ZO1_HUMAN	tight junction protein 1	1744					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		TGGTCAATAAGGACAGAAACA	0.348000													12	32					0	0	1	0	0
DRG2	1819	broad.mit.edu	37	17	18002954	18002954	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:18002954C>T	ENST00000225729.3	+	5	522	c.384C>T	c.(382-384)ggC>ggT	p.G128G	DRG2_ENST00000395726.4_Silent_p.G128G|DRG2_ENST00000583355.1_Intron	NM_001388.4	NP_001379.1	P55039	DRG2_HUMAN	developmentally regulated GTP binding protein 2	128	G.				signal transduction		GTP binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	14	all_neural(463;0.228)					CAGGAAAAGGCCGTGGCCGGC	0.612000													3	5					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51870774	51870774	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:51870774G>A	ENST00000371497.5	+	2	1664	c.777G>A	c.(775-777)agG>agA	p.R259R	TSHZ2_ENST00000329613.6_Silent_p.R256R|TSHZ2_ENST00000603338.2_Silent_p.R256R	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	259					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			CAAAGCCCAGGAAAAGGGCTT	0.478000													15	25					0	0	1	0	0
TRPC7	57113	broad.mit.edu	37	5	135583173	135583173	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:135583173G>A	ENST00000513104.1	-	7	2112	c.1830C>T	c.(1828-1830)aaC>aaT	p.N610N	TRPC7_ENST00000355180.3_Silent_p.N549N|TRPC7_ENST00000426057.2_Silent_p.N494N	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	610					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TAAACGCTGGGTTGTATTTGG	0.473000													7	16					0	0	1	0	0
ABCC1	4363	broad.mit.edu	37	16	16232341	16232341	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr16:16232341C>T	ENST00000399408.2	+	31	4618	c.4443C>T	c.(4441-4443)acC>acT	p.T1481T	ABCC1_ENST00000346370.5_Silent_p.T1415T|ABCC1_ENST00000351154.5_Silent_p.T1412T|ABCC1_ENST00000349029.5_Silent_p.T1356T|ABCC1_ENST00000399410.3_Silent_p.T1471T|ABCC1_ENST00000345148.5_Intron			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	1471	ABC transporter 2.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TCCAGTCCACCATCCGGACAC	0.607000													11	11					0	0	1	0	0
PSME2	5721	broad.mit.edu	37	14	24614322	24614322	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:24614322G>A	ENST00000216802.5	-	6	944	c.305C>T	c.(304-306)tCc>tTc	p.S102F	PSME2_ENST00000560410.1_Missense_Mutation_p.S91F|PSME2_ENST00000471700.2_5'UTR	NM_002818.2	NP_002809.2	Q9UL46	PSME2_HUMAN	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)	102					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome activator complex				endometrium(1)|lung(3)|prostate(2)	6				GBM - Glioblastoma multiforme(265;0.00839)		GGCAAGCAGGGACAGGACTTT	0.502000													36	47					0	0	1	0	0
HDC	3067	broad.mit.edu	37	15	50534849	50534849	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:50534849G>A	ENST00000267845.3	-	12	1999	c.1597C>T	c.(1597-1599)Ccc>Tcc	p.P533S	HDC_ENST00000543581.1_Missense_Mutation_p.P500S	NM_002112.3	NP_002103.2	P19113	DCHS_HUMAN	histidine decarboxylase	533					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	CTTTTCATGGGACCGGCTCCC	0.567000													17	38					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40052233	40052233	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:40052233G>A	ENST00000373233.3	-	30	4631	c.4454C>T	c.(4453-4455)tCc>tTc	p.S1485F		NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1485					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				GTCCAAACGGGAAATGATGCG	0.443000													69	90					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29556474	29556474	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:29556474C>T	ENST00000358273.4	+	21	3224	c.2841C>T	c.(2839-2841)tcC>tcT	p.S947S	NF1_ENST00000356175.3_Silent_p.S947S	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	947					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(4)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TTTTTGACTCCCAAGGACAGG	0.348000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			21	44					0	0	1	0	0
OR4K2	390431	broad.mit.edu	37	14	20345329	20345329	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:20345329G>A	ENST00000298642.2	+	1	939	c.903G>A	c.(901-903)ctG>ctA	p.L301L		NM_001005501.1	NP_001005501.1	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K, member 2	301					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(16)|ovary(2)|skin(9)|upper_aerodigestive_tract(2)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGAGGAAACTGAAAAATAGGT	0.348000													13	79					0	0	1	0	0
GIF	2694	broad.mit.edu	37	11	59604786	59604786	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:59604786C>T	ENST00000541311.1	-	6	891	c.657G>A	c.(655-657)tgG>tgA	p.W219*	GIF_ENST00000257248.2_Nonsense_Mutation_p.W244*			P27352	IF_HUMAN	gastric intrinsic factor (vitamin B synthesis)	244					cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			large_intestine(4)|liver(1)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	17						TCTTGCAGTTCCATTCCTTTT	0.448000													4	19					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73063723	73063723	+	RNA	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:73063723G>A	ENST00000429829.1	-	0	8865					NR_001564.2																						AAAGGTGATGGGGTATGACCT	0.408000													5	4					0	0	1	0	0
C3orf22	152065	broad.mit.edu	37	3	126268923	126268923	+	Splice_Site	SNP	T	T	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:126268923T>A	ENST00000318225.2	-	4	594		c.e4-2			NM_152533.1	NP_689746.1	Q8N5N4	CC022_HUMAN	chromosome 3 open reading frame 22											large_intestine(1)|lung(3)|ovary(2)|prostate(1)	7				GBM - Glioblastoma multiforme(114;0.147)		GCCCCGAGCCTAGAGAAGCCA	0.612000													9	14					0	0	1	0	0
OR1N1	138883	broad.mit.edu	37	9	125288701	125288701	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:125288701C>G	ENST00000304880.2	-	1	871	c.872G>C	c.(871-873)aGg>aCg	p.R291T		NM_012363.1	NP_036495.1	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N, member 1	291					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|large_intestine(2)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						GTCCTTGTTCCTTAGGCTATA	0.463000													10	4					0	0	1	0	0
DIP2C	22982	broad.mit.edu	37	10	436729	436729	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:436729G>A	ENST00000280886.6	-	11	1422	c.1335C>T	c.(1333-1335)tgC>tgT	p.C445C	DIP2C_ENST00000381496.3_Silent_p.C338C	NM_014974.2	NP_055789.1	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C (Drosophila)	445						nucleus	catalytic activity|transcription factor binding			breast(8)|endometrium(6)|kidney(10)|large_intestine(13)|lung(26)|ovary(3)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	81		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		GTCCTTTATGGCAGGCGTCAC	0.537000													27	51					0	0	1	0	0
IRAK2	3656	broad.mit.edu	37	3	10280489	10280489	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:10280489C>T	ENST00000256458.4	+	12	1621	c.1531C>T	c.(1531-1533)Cct>Tct	p.P511S		NM_001570.3	NP_001561.3	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	511					activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			breast(4)|large_intestine(8)|lung(11)|prostate(1)|stomach(1)	25						GACGTTGCTCCCTTGGAGTGG	0.562000													24	45					0	0	1	0	0
PTGFR	5737	broad.mit.edu	37	1	78958793	78958793	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:78958793C>T	ENST00000370756.3	+	2	602	c.365C>T	c.(364-366)cCa>cTa	p.P122L	PTGFR_ENST00000370757.3_Missense_Mutation_p.P122L|PTGFR_ENST00000370758.1_Missense_Mutation_p.P122L	NM_001039585.1	NP_001034674.1	P43088	PF2R_HUMAN	prostaglandin F receptor (FP)	122					parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			breast(6)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	33				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	GGTCTGTGCCCACTTCTTCTA	0.388000													16	42					0	0	1	0	0
AOC4P	90586	broad.mit.edu	37	17	41020220	41020220	+	RNA	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:41020220C>T	ENST00000585538.1	+	0	1059					NR_002773.1																						GCCCCCGGGTCCAGCTCCCCC	0.642000													10	12					0	0	1	0	0
KREMEN1	83999	broad.mit.edu	37	22	29494916	29494916	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr22:29494916G>A	ENST00000400338.2	+	3	380	c.327G>A	c.(325-327)aaG>aaA	p.K109K	KREMEN1_ENST00000400335.4_Silent_p.K109K|KREMEN1_ENST00000407188.1_Silent_p.K107K|KREMEN1_ENST00000327813.5_Silent_p.K109K			Q96MU8	KREM1_HUMAN	kringle containing transmembrane protein 1	107	Kringle.				cell communication|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane|membrane fraction	protein binding			breast(1)|endometrium(3)|large_intestine(2)|lung(8)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	20						TCTACTGGAAGTACTGTGAGA	0.502000													18	16					0	0	1	0	0
C14orf166B	145497	broad.mit.edu	37	14	77327075	77327075	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:77327075G>A	ENST00000393774.3	+	11	1268	c.1144G>A	c.(1144-1146)Gga>Aga	p.G382R		NM_194287.2	NP_919263.2	Q0VAA2	CN16B_HUMAN	chromosome 14 open reading frame 166B	382										breast(1)|kidney(2)|large_intestine(3)|lung(9)|prostate(2)|skin(1)	18			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0306)		AACGTTGGACGGAGTGTATGC	0.542000													9	14					0	0	1	0	0
MX1	4599	broad.mit.edu	37	21	42808946	42808946	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr21:42808946C>T	ENST00000398600.2	+	9	1328	c.303C>T	c.(301-303)atC>atT	p.I101I	MX1_ENST00000288383.6_Silent_p.I78I|MX1_ENST00000455164.2_Silent_p.I101I|MX1_ENST00000398598.3_Silent_p.I101I	NM_001144925.1	NP_001138397.1	P20591	MX1_HUMAN	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	101					induction of apoptosis|response to virus|type I interferon-mediated signaling pathway	cytosol	GTP binding|GTPase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	27		Prostate(19;3.18e-07)|all_epithelial(19;0.0277)				TCCTAGGGATCGTGACCAGAT	0.478000													16	19					0	0	1	0	0
PRMT5	10419	broad.mit.edu	37	14	23394111	23394111	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:23394111C>G	ENST00000324366.8	-	8	1139	c.916G>C	c.(916-918)Gac>Cac	p.D306H	PRMT5-AS1_ENST00000595662.1_RNA|PRMT5-AS1_ENST00000587245.2_RNA|PRMT5_ENST00000216350.8_Missense_Mutation_p.D245H|PRMT5-AS1_ENST00000590290.1_RNA|PRMT5-AS1_ENST00000599580.1_RNA|PRMT5_ENST00000397440.4_Missense_Mutation_p.D135H|PRMT5_ENST00000397441.2_Missense_Mutation_p.D289H|PRMT5_ENST00000553897.1_Missense_Mutation_p.D262H|PRMT5_ENST00000538452.1_Missense_Mutation_p.D200H	NM_006109.3	NP_006100.2	O14744	ANM5_HUMAN	protein arginine methyltransferase 5	306					cell proliferation|histone H4-R3 methylation|ncRNA metabolic process|regulation of mitosis|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	histone-arginine N-methyltransferase activity|protein binding|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			endometrium(4)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	25	all_cancers(95;2.76e-05)			GBM - Glioblastoma multiforme(265;0.0126)		TGCAGATAGTCTTCATAGCCC	0.478000													7	81					0	0	1	0	0
HMGCLL1	54511	broad.mit.edu	37	6	55360397	55360397	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:55360397C>T	ENST00000398661.2	-	8	836	c.705G>A	c.(703-705)aaG>aaA	p.K235K	HMGCLL1_ENST00000274901.4_Silent_p.K205K|HMGCLL1_ENST00000370850.2_Silent_p.K102K|HMGCLL1_ENST00000308161.4_Silent_p.K173K|HMGCLL1_ENST00000508459.1_Intron	NM_019036.2	NP_061909.2	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1	235							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	31	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			CGTACAATCTCTTAGACACCT	0.388000													17	21					0	0	1	0	0
ATCAY	85300	broad.mit.edu	37	19	3905637	3905637	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:3905637C>G	ENST00000450849.2	+	4	809	c.342C>G	c.(340-342)aaC>aaG	p.N114K	ATCAY_ENST00000398448.3_Missense_Mutation_p.N120K|ATCAY_ENST00000301260.6_Missense_Mutation_p.N114K|ATCAY_ENST00000600960.1_Missense_Mutation_p.N114K	NM_033064.4	NP_149053.1	Q86WG3	ATCAY_HUMAN	ataxia, cerebellar, Cayman type	114					transport		protein binding			breast(1)|endometrium(2)|kidney(2)|lung(2)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)		GGAATGGCAACGAACTGGAGT	0.577000													22	73					0	0	1	0	0
GRHL3	57822	broad.mit.edu	37	1	24663144	24663144	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:24663144C>T	ENST00000361548.4	+	4	669	c.439C>T	c.(439-441)Ccc>Tcc	p.P147S	GRHL3_ENST00000356046.2_Missense_Mutation_p.P101S|GRHL3_ENST00000342072.4_Missense_Mutation_p.P54S|GRHL3_ENST00000236255.4_Missense_Mutation_p.P152S|GRHL3_ENST00000530984.1_3'UTR|GRHL3_ENST00000350501.5_Missense_Mutation_p.P147S	NM_198173.2	NP_937816.1	Q8TE85	GRHL3_HUMAN	grainyhead-like 3 (Drosophila)	147					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		CAAGGCAGCTCCCCTCCCTGC	0.567000													47	56					0	0	1	0	0
UROC1	131669	broad.mit.edu	37	3	126236519	126236519	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:126236519G>A	ENST00000290868.2	-	1	97	c.44C>T	c.(43-45)cCc>cTc	p.P15L	UROC1_ENST00000383579.3_Missense_Mutation_p.P15L	NM_144639.2	NP_653240.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1	15					histidine catabolic process	cytosol	urocanate hydratase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(1)|skin(1)	39				GBM - Glioblastoma multiforme(114;0.17)		CTCTGGGAGGGGCCGCAGGGG	0.677000													3	6					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94088185	94088185	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:94088185G>A	ENST00000553484.1	+	31	4826	c.4672G>A	c.(4672-4674)Gcg>Acg	p.A1558T	UNC79_ENST00000393151.2_Missense_Mutation_p.A1536T|UNC79_ENST00000555664.1_Missense_Mutation_p.A1536T|UNC79_ENST00000256339.4_Missense_Mutation_p.A1359T			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1536						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						GACCCAAGCTGCGTATATCGC	0.488000													33	21					0	0	1	0	0
ATP2B3	492	broad.mit.edu	37	X	152807185	152807185	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:152807185C>T	ENST00000370186.1	+	4	791	c.465C>T	c.(463-465)atC>atT	p.I155I	ATP2B3_ENST00000370181.2_Silent_p.I155I|ATP2B3_ENST00000359149.3_Silent_p.I155I|ATP2B3_ENST00000393842.1_Silent_p.I155I|ATP2B3_ENST00000349466.2_Silent_p.I155I|ATP2B3_ENST00000263519.4_Silent_p.I155I			Q16720	AT2B3_HUMAN	ATPase, Ca++ transporting, plasma membrane 3	155					ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			NS(2)|breast(5)|endometrium(7)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(3)	50	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTGGCTGGATCGAGGGGGCTG	0.617000													34	18					0	0	1	0	0
C2CD2	25966	broad.mit.edu	37	21	43325928	43325928	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr21:43325928G>A	ENST00000380486.3	-	11	1578	c.1337C>T	c.(1336-1338)cCc>cTc	p.P446L	C2CD2_ENST00000329623.7_Missense_Mutation_p.P291L	NM_015500.1	NP_056315.1	Q9Y426	CU025_HUMAN	C2 calcium-dependent domain containing 2	446						cytosol|extracellular region|nucleus				endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|stomach(1)	15						CACCTTGATGGGAGTCTTCAC	0.542000													9	14					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73498378	73498378	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:73498378G>A	ENST00000224721.6	+	34	4353	c.4348G>A	c.(4348-4350)Gac>Aac	p.D1450N		NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	1445	Cadherin 14.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						CAAGGCCTGGGACCCTGATGC	0.642000													8	12					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57640962	57640962	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:57640962C>T	ENST00000254181.4	+	4	1373	c.919C>T	c.(919-921)Cca>Tca	p.P307S	USP29_ENST00000598197.1_Missense_Mutation_p.P307S	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	307					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATTTGCAATTCCATCTTTTGC	0.443000													17	40					0	0	1	0	0
AXL	558	broad.mit.edu	37	19	41763460	41763460	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:41763460G>A	ENST00000301178.4	+	19	2449	c.2259G>A	c.(2257-2259)gtG>gtA	p.V753V	AXL_ENST00000593513.1_Silent_p.V485V|AXL_ENST00000359092.3_Silent_p.V744V	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	753	Protein kinase.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						ATCCGGGCGTGGAGAACAGCG	0.567000													25	70					0	0	1	0	0
LRRC4C	57689	broad.mit.edu	37	11	40137212	40137212	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:40137212C>T	ENST00000278198.2	-	2	2594	c.631G>A	c.(631-633)Gaa>Aaa	p.E211K	LRRC4C_ENST00000530763.1_Missense_Mutation_p.E211K|LRRC4C_ENST00000528697.1_Missense_Mutation_p.E211K|LRRC4C_ENST00000527150.1_Missense_Mutation_p.E211K			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	211					regulation of axonogenesis	integral to membrane	protein binding	p.E211*(1)		NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				TTAGGGATTTCCCGAAGGTTG	0.453000													17	42					0	0	1	0	0
OR5D16	390144	broad.mit.edu	37	11	55606653	55606653	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:55606653C>T	ENST00000378396.1	+	1	426	c.426C>T	c.(424-426)ctC>ctT	p.L142L		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	142					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				CCCAGAAACTCTGTGCCATGC	0.453000													26	31					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	132192469	132192469	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:132192469G>A	ENST00000359827.3	-	2	1946	c.984C>T	c.(982-984)gtC>gtT	p.V328V	PLXNA4_ENST00000321063.4_Silent_p.V328V|PLXNA4_ENST00000423507.2_Silent_p.V328V|PLXNA4_ENST00000378539.5_Silent_p.V328V			Q9HCM2	PLXA4_HUMAN	plexin A4	328	Sema.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						CATCTGGATGGACTCCAAGGG	0.592000													28	21					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101520688	101520688	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:101520688C>T	ENST00000392979.3	+	26	2964	c.2603C>T	c.(2602-2604)tCa>tTa	p.S868L	ANO4_ENST00000550015.1_Missense_Mutation_p.S423L|ANO4_ENST00000299222.9_Missense_Mutation_p.S423L|ANO4_ENST00000392977.3_Missense_Mutation_p.S903L	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	903						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						CACCTCATTTCATATCTGATC	0.443000										HNSCC(74;0.22)			12	11					0	0	1	0	0
TEAD1	7003	broad.mit.edu	37	11	12951768	12951768	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:12951768C>T	ENST00000361905.4	+	12	1682	c.1017C>T	c.(1015-1017)aaC>aaT	p.N339N	TEAD1_ENST00000334310.6_Silent_p.N285N|TEAD1_ENST00000527575.1_Silent_p.N296N|TEAD1_ENST00000526600.1_Silent_p.N258N|TEAD1_ENST00000527636.1_Silent_p.N354N|TEAD1_ENST00000361985.2_Silent_p.N354N	NM_021961.5	NP_068780.2	P28347	TEAD1_HUMAN	TEA domain family member 1 (SV40 transcriptional enhancer factor)	354	Transcriptional activation (Potential).				hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)	17				Epithelial(150;0.00223)|BRCA - Breast invasive adenocarcinoma(625;0.236)		ACCGAATAAACCGCTCCCCAA	0.363000													17	45					0	0	1	0	0
OGN	4969	broad.mit.edu	37	9	95163468	95163468	+	Splice_Site	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:95163468C>T	ENST00000262551.4	-	3	595		c.e3-1		OGN_ENST00000375561.5_Splice_Site|CENPP_ENST00000375587.3_Intron	NM_033014.2	NP_148935.1	P20774	MIME_HUMAN	osteoglycin							extracellular space|proteinaceous extracellular matrix	growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|prostate(1)|urinary_tract(1)	13						TTTCTTTTTCCTATTGGAAAA	0.343000													15	4					0	0	1	0	0
CAMK1	8536	broad.mit.edu	37	3	9804684	9804684	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:9804684C>T	ENST00000256460.3	-	5	520	c.343G>A	c.(343-345)Gag>Aag	p.E115K	OGG1_ENST00000449570.2_Intron|OGG1_ENST00000349503.5_Intron|OGG1_ENST00000383826.5_Intron|OGG1_ENST00000302036.7_Intron|OGG1_ENST00000302008.8_Intron	NM_003656.4	NP_003647.1	Q14012	KCC1A_HUMAN	calcium/calmodulin-dependent protein kinase I	115	Protein kinase.				cell differentiation|nervous system development|positive regulation of muscle cell differentiation|signal transduction	cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	12	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.0475)		GCGTCCCGCTCCGTGTAGAAG	0.592000													7	23					0	0	1	0	0
PDCL3	79031	broad.mit.edu	37	2	101188240	101188240	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:101188240G>A	ENST00000264254.6	+	5	935	c.557G>A	c.(556-558)gGc>gAc	p.G186D		NM_024065.4	NP_076970.1	Q9H2J4	PDCL3_HUMAN	phosducin-like 3	186					apoptosis|interspecies interaction between organisms	cytoplasm	protein binding			endometrium(3)|large_intestine(2)|liver(1)|lung(6)	12						GTGTTTGGCGGCATGAACCTG	0.498000													4	97					0	0	1	0	0
DGKG	1608	broad.mit.edu	37	3	186002461	186002461	+	Silent	SNP	G	G	A	rs150564600	by1000genomes	TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:186002461G>A	ENST00000265022.3	-	7	1121	c.582C>T	c.(580-582)ctC>ctT	p.L194L	DGKG_ENST00000544847.1_Silent_p.L194L|DGKG_ENST00000344484.4_Silent_p.L194L|DGKG_ENST00000382164.4_Silent_p.L194L	NM_001080744.1|NM_001080745.1|NM_001346.2	NP_001074213.1|NP_001074214.1|NP_001337.2	P49619	DGKG_HUMAN	diacylglycerol kinase, gamma 90kDa	194	EF-hand 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	42	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	CTTGGTCCAGGAGACCGTTCT	0.483000													17	21					0	0	1	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140772512	140772512	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:140772512C>T	ENST00000398604.2	+	1	132	c.132C>T	c.(130-132)ttC>ttT	p.F44F	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGGCTCCTTCGTGGGTAATA	0.602000													8	28					0	0	1	0	0
NGFR	4804	broad.mit.edu	37	17	47587799	47587799	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:47587799G>A	ENST00000172229.3	+	4	719	c.594G>A	c.(592-594)cgG>cgA	p.R198R	NGFR_ENST00000504201.1_Silent_p.R104R|RP5-1029K10.2_ENST00000514506.1_RNA	NM_002507.3	NP_002498.1	P08138	TNR16_HUMAN	nerve growth factor receptor	198	Ser/Thr-rich.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|negative regulation of axonogenesis|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis	cell surface|cytosol|endosome|extracellular region|integral to plasma membrane|nucleoplasm				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)	17	all_cancers(4;1.45e-13)|Breast(4;6.34e-28)|all_epithelial(4;4.95e-17)					GGATTACACGGTCCACACCCC	0.617000													19	41					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20535232	20535232	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:20535232G>A	ENST00000504154.1	+	18	1978	c.1726G>A	c.(1726-1728)Gga>Aga	p.G576R	SLIT2_ENST00000273739.5_Missense_Mutation_p.G580R|SLIT2_ENST00000503837.1_Missense_Mutation_p.G572R|SLIT2_ENST00000503823.1_Missense_Mutation_p.G568R	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	576					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						TATTGAGGAGGGAGCATTTGA	0.338000													9	20					0	0	1	0	0
EXOC8	149371	broad.mit.edu	37	1	231472295	231472295	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:231472295G>A	ENST00000366645.1	-	1	1303	c.1185C>T	c.(1183-1185)tcC>tcT	p.S395S	EXOC8_ENST00000360394.2_Silent_p.S399S			Q8IYI6	EXOC8_HUMAN	exocyst complex component 8	399					exocytosis|protein transport	growth cone|nucleus	protein binding			cervix(2)|endometrium(1)|large_intestine(2)|liver(1)|lung(5)|prostate(1)|skin(1)|stomach(1)	14	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				AACGATCTGGGGAGAGTTCGA	0.537000													16	26					0	0	1	0	0
LPPR4	9890	broad.mit.edu	37	1	99772543	99772543	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:99772543C>T	ENST00000370185.3	+	7	2766	c.2269C>T	c.(2269-2271)Ccc>Tcc	p.P757S	LPPR4_ENST00000370184.1_Missense_Mutation_p.P599S|LPPR4_ENST00000457765.1_Missense_Mutation_p.P699S	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		757							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		AGGAACCTCCCCCACACGGGC	0.463000													25	47					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1260910	1260910	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr16:1260910G>A	ENST00000348261.5	+	21	4410	c.4162G>A	c.(4162-4164)Ggc>Agc	p.G1388S	CACNA1H_ENST00000565831.1_Missense_Mutation_p.G1388S|CACNA1H_ENST00000358590.4_Missense_Mutation_p.G1388S	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	1388					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CTCGGCTGGTGGCGCCAAGAT	0.692000													32	45					0	0	1	0	0
SAP130	79595	broad.mit.edu	37	2	128775270	128775270	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:128775270G>A	ENST00000357702.5	-	3	541	c.410C>T	c.(409-411)tCg>tTg	p.S137L	SAP130_ENST00000259235.3_Missense_Mutation_p.S137L|SAP130_ENST00000259234.6_Missense_Mutation_p.S111L	NM_001145928.1	NP_001139400.1	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa	137	Pro-rich.				histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			NS(4)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	45	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		AAGTCCCTCCGAAAATGAAAG	0.488000													21	34					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65350557	65350557	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:65350557G>A	ENST00000330909.8	-	20	3344	c.3345C>T	c.(3343-3345)acC>acT	p.T1115T	MAGI1_ENST00000483466.1_Silent_p.T1116T|MAGI1_ENST00000497477.2_Silent_p.T1020T|MAGI1_ENST00000402939.2_Silent_p.T1087T	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	1116					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		GCTGAGAAGGGGTGTGTGTGG	0.478000													26	43					0	0	1	0	0
OR10K1	391109	broad.mit.edu	37	1	158436256	158436256	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:158436256G>A	ENST00000289451.2	+	1	985	c.905G>A	c.(904-906)cGa>cAa	p.R302Q		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					TCAGCCCTACGAAGAACAATC	0.373000													17	26					0	0	1	0	0
RAG1	5896	broad.mit.edu	37	11	36594965	36594965	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:36594965C>T	ENST00000299440.5	+	2	223	c.111C>T	c.(109-111)tcC>tcT	p.S37S		NM_000448.2	NP_000439.1	P15918	RAG1_HUMAN	recombination activating gene 1	37	Interaction with importin alpha-1.				histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	65	all_lung(20;0.226)	all_hematologic(20;0.107)				GGGTGAGATCCTTTGAAAAGA	0.463000									Familial Hemophagocytic Lymphohistiocytosis				22	37					0	0	1	0	0
HCK	3055	broad.mit.edu	37	20	30659483	30659483	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:30659483C>T	ENST00000534862.1	+	3	384	c.21C>T	c.(19-21)tcC>tcT	p.S7S	HCK_ENST00000375862.2_Silent_p.S27S|HCK_ENST00000375852.2_Silent_p.S27S|HCK_ENST00000518730.1_Silent_p.S6S|HCK_ENST00000520553.1_Silent_p.S6S|HCK_ENST00000538448.1_Silent_p.S6S	NM_001172132.1	NP_001165603.1	P08631	HCK_HUMAN	hemopoietic cell kinase	27					interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			NS(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(4)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GCATGAAGTCCAAGTTCCTCC	0.562000													22	28					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26094815	26094815	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:26094815G>A	ENST00000313735.6	-	18	2316	c.2083C>T	c.(2083-2085)Ccc>Tcc	p.P695S		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	695					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding	p.P695T(2)		autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	TAGAGCTTGGGGATCTGAATG	0.567000													8	25					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62296432	62296432	+	Silent	SNP	A	A	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:62296432A>G	ENST00000378024.4	-	5	5731	c.5457T>C	c.(5455-5457)ggT>ggC	p.G1819G	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	1819					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				CCACAAAAGGACCTTTGACAT	0.502000													50	79					0	0	1	0	0
ARPP21	10777	broad.mit.edu	37	3	35731618	35731618	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:35731618C>T	ENST00000187397.4	+	8	987	c.531C>T	c.(529-531)ttC>ttT	p.F177F	ARPP21_ENST00000417925.1_Silent_p.F177F|ARPP21_ENST00000337271.5_Silent_p.F177F|ARPP21_ENST00000458225.1_Silent_p.F177F|ARPP21_ENST00000444190.1_Silent_p.F177F	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	177	R3H.					cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						TTATTGATTTCATTGCTGACA	0.318000													7	18					0	0	1	0	0
ENTPD1	953	broad.mit.edu	37	10	97607294	97607294	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:97607294C>T	ENST00000371203.5	+	6	1078	c.491C>T	c.(490-492)aCc>aTc	p.T164I	ENTPD1_ENST00000543964.1_Missense_Mutation_p.T194I|ENTPD1_ENST00000539125.1_Missense_Mutation_p.T164I|ENTPD1_ENST00000453258.2_Missense_Mutation_p.T309I|ENTPD1-AS1_ENST00000416301.1_RNA|RP11-429G19.3_ENST00000433113.1_RNA|ENTPD1_ENST00000371205.4_Missense_Mutation_p.T302I|ENTPD1_ENST00000371207.3_Missense_Mutation_p.T314I	NM_001164179.1|NM_001164182.1|NM_001776.5	NP_001157651.1|NP_001157654.1|NP_001767.3	P49961	ENTP1_HUMAN	ectonucleoside triphosphate diphosphohydrolase 1	302					cell adhesion	integral to plasma membrane	ATP binding			cervix(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(3)|prostate(1)|skin(1)	16		Colorectal(252;0.0821)		Epithelial(162;1.31e-07)|all cancers(201;5.33e-06)		ACCCCCTGCACCAAGAGATTT	0.438000													19	47					0	0	1	0	0
OTOA	146183	broad.mit.edu	37	16	21712301	21712301	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr16:21712301G>A	ENST00000388958.3	+	10	934	c.933G>A	c.(931-933)agG>agA	p.R311R	OTOA_ENST00000388956.4_Silent_p.R232R|OTOA_ENST00000286149.4_Silent_p.R311R	NM_144672.3	NP_653273.3	Q7RTW8	OTOAN_HUMAN	otoancorin	311					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)	46				GBM - Glioblastoma multiforme(48;0.0414)		TTCTGGAGAGGATCAGCTCCT	0.527000													13	22					0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121650545	121650545	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:121650545C>T	ENST00000393386.2	+	12	1856	c.1445C>T	c.(1444-1446)tCc>tTc	p.S482F	PTPRZ1_ENST00000449182.1_Missense_Mutation_p.S482F	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	482					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						ACTAACCGATCCCCAACAAGA	0.413000													47	36					0	0	1	0	0
SAMD7	344658	broad.mit.edu	37	3	169644384	169644384	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:169644384G>A	ENST00000428432.2	+	6	723	c.334G>A	c.(334-336)Gaa>Aaa	p.E112K	SAMD7_ENST00000335556.3_Missense_Mutation_p.E112K	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	112										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			AAGGAGAATGGAAAAAATTAA	0.428000													13	23					0	0	1	0	0
TINAGL1	64129	broad.mit.edu	37	1	32051392	32051392	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:32051392G>A	ENST00000271064.7	+	10	1208	c.1132G>A	c.(1132-1134)Gga>Aga	p.G378R	TINAGL1_ENST00000481165.1_3'UTR|TINAGL1_ENST00000457433.2_Missense_Mutation_p.G347R	NM_001204415.1|NM_022164.2	NP_001191344.1|NP_071447.1	Q9GZM7	TINAL_HUMAN	tubulointerstitial nephritis antigen-like 1	378					endosome transport|immune response|proteolysis	extracellular region	cysteine-type endopeptidase activity|extracellular matrix structural constituent|polysaccharide binding|scavenger receptor activity			breast(2)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(4)|prostate(1)|skin(3)|urinary_tract(1)	18		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		STAD - Stomach adenocarcinoma(196;0.0526)|READ - Rectum adenocarcinoma(331;0.145)		CCTATACAAGGGAGGCATCTA	0.602000													3	8					0	0	1	0	0
EBF3	253738	broad.mit.edu	37	10	131666048	131666048	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:131666048C>T	ENST00000368648.3	-	9	955	c.883G>A	c.(883-885)Gag>Aag	p.E295K	EBF3_ENST00000355311.5_Missense_Mutation_p.E304K	NM_001005463.2	NP_001005463.1	Q9H4W6	COE3_HUMAN	early B-cell factor 3	304	IPT/TIG.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	44		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		GGGCTTACCTCGCTCCACACC	0.527000													10	14					0	0	1	0	0
AMZ2P1	201283	broad.mit.edu	37	17	62968690	62968690	+	RNA	SNP	A	A	G	rs138671696	by1000genomes	TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:62968690A>G	ENST00000430983.1	-	0	1554					NR_026903.1																						AAAATTCCACAAGTCTCTTGG	0.373000													6	101					0	0	1	0	0
KIF13B	23303	broad.mit.edu	37	8	29023224	29023224	+	Silent	SNP	A	A	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:29023224A>C	ENST00000524189.1	-	12	1262	c.1224T>G	c.(1222-1224)acT>acG	p.T408T	KIF13B_ENST00000521515.1_Silent_p.T408T	NM_015254.3	NP_056069.2	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	408					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding			endometrium(6)|kidney(1)|lung(20)|urinary_tract(1)	28		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		CCCAGGTCACAGTCATTTCCT	0.443000													14	24					0	0	1	0	0
ZNF683	257101	broad.mit.edu	37	1	26691607	26691607	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:26691607C>T	ENST00000436292.1	-	4	550	c.430G>A	c.(430-432)Ggg>Agg	p.G144R	ZNF683_ENST00000374204.1_Missense_Mutation_p.G144R|ZNF683_ENST00000403843.1_Missense_Mutation_p.G144R|ZNF683_ENST00000349618.3_Missense_Mutation_p.G144R			Q8IZ20	ZN683_HUMAN	zinc finger protein 683	144					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(1)	15		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		CAGGGGGCCCCCTCGCCAGCT	0.597000													5	3					0	0	1	0	0
SLC39A12	221074	broad.mit.edu	37	10	18250624	18250624	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:18250624G>A	ENST00000377369.2	+	3	649	c.376G>A	c.(376-378)Gaa>Aaa	p.E126K	SLC39A12_ENST00000539911.1_5'UTR|SLC39A12_ENST00000377371.3_Missense_Mutation_p.E126K|SLC39A12_ENST00000377374.4_Missense_Mutation_p.E126K	NM_001145195.1	NP_001138667.1	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter), member 12	126					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|kidney(3)|large_intestine(5)|lung(38)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	60						TATTCATCAGGAAGAGATCTG	0.383000													10	39					0	0	1	0	0
DTNB	1838	broad.mit.edu	37	2	25851216	25851216	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:25851216G>A	ENST00000406818.3	-	4	435	c.186C>T	c.(184-186)ttC>ttT	p.F62F	DTNB_ENST00000288642.8_Silent_p.F62F|DTNB_ENST00000472690.1_5'UTR|DTNB_ENST00000407661.3_Silent_p.F62F|DTNB_ENST00000407038.3_Silent_p.F62F|DTNB_ENST00000407186.1_Silent_p.F62F|DTNB_ENST00000405222.1_Silent_p.F62F|DTNB_ENST00000404103.3_Silent_p.F62F|DTNB_ENST00000545439.1_5'UTR|DTNB_ENST00000496972.2_Silent_p.F5F	NM_001256303.1|NM_021907.4	NP_001243232.1|NP_068707.1	O60941	DTNB_HUMAN	dystrobrevin, beta	62						cytoplasm	calcium ion binding|zinc ion binding			endometrium(1)|large_intestine(3)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CATTGTCTCGGAAGGCTTCAA	0.423000													10	7					0	0	1	0	0
RER1	11079	broad.mit.edu	37	1	2327258	2327258	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:2327258C>T	ENST00000605895.1	+	2	162	c.29C>T	c.(28-30)tCc>tTc	p.S10F	RER1_ENST00000378512.1_Missense_Mutation_p.S10F|RER1_ENST00000378513.3_Missense_Mutation_p.S10F|RER1_ENST00000378518.1_Missense_Mutation_p.S10F|RER1_ENST00000488353.1_Missense_Mutation_p.S10F	NM_007033.4	NP_008964.3	O15258	RER1_HUMAN	retention in endoplasmic reticulum sorting receptor 1	10					retrograde vesicle-mediated transport, Golgi to ER	integral to Golgi membrane				endometrium(3)|kidney(1)	4	all_cancers(77;0.000247)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;5.35e-20)|all_lung(118;2.78e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.28e-37)|OV - Ovarian serous cystadenocarcinoma(86;8.29e-23)|GBM - Glioblastoma multiforme(42;4.71e-08)|Colorectal(212;4.73e-05)|COAD - Colon adenocarcinoma(227;0.00021)|Kidney(185;0.00116)|BRCA - Breast invasive adenocarcinoma(365;0.00459)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0182)|Lung(427;0.204)		GTGGGAGAATCCGTCCATGGG	0.408000													11	23					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160047460	160047460	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:160047460C>T	ENST00000327245.5	-	15	3156	c.2310G>A	c.(2308-2310)agG>agA	p.R770R	CTC-348L5.1_ENST00000523598.1_RNA	NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	770					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACATTCTCTTCCTGACAGAGT	0.592000													8	22					0	0	1	0	0
USP24	23358	broad.mit.edu	37	1	55598326	55598326	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:55598326G>A	ENST00000294383.6	-	31	3428	c.3429C>T	c.(3427-3429)tcC>tcT	p.S1143S	USP24_ENST00000407756.1_Silent_p.S983S	NM_015306.2	NP_056121.2	Q9UPU5	UBP24_HUMAN	ubiquitin specific peptidase 24	1143	Ser-rich.				ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|cervix(1)|endometrium(8)|kidney(13)|large_intestine(7)|lung(16)|ovary(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	60						TTGATGACAGGGATGGAGATT	0.393000													7	15					0	0	1	0	0
MFSD8	256471	broad.mit.edu	37	4	128861129	128861129	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:128861129G>A	ENST00000296468.3	-	7	704	c.577C>T	c.(577-579)Ctt>Ttt	p.L193F	MFSD8_ENST00000515130.1_5'UTR|MFSD8_ENST00000541133.1_Intron|MFSD8_ENST00000513559.1_Missense_Mutation_p.L148F	NM_152778.2	NP_689991.1	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing 8	193					cell death|transmembrane transport	integral to membrane|lysosomal membrane				cervix(2)|endometrium(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)	23						TTTTCTCCAAGGAATGTAAAA	0.289000													17	35					0	0	1	0	0
SLC24A3	57419	broad.mit.edu	37	20	19677555	19677555	+	Splice_Site	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:19677555G>A	ENST00000328041.6	+	14	1803	c.1606_splice	c.e14+1	p.G536_splice		NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	536						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						GGCCAGACAAGGTGGGACTTC	0.617000													11	17					0	0	1	0	0
UGT2A1	10941	broad.mit.edu	37	4	70512854	70512854	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:70512854G>A	ENST00000503640.1	-	1	564	c.509C>T	c.(508-510)tCc>tTc	p.S170F	UGT2A1_ENST00000286604.4_Missense_Mutation_p.S170F|UGT2A1_ENST00000514019.1_Missense_Mutation_p.S170F|UGT2A1_ENST00000512704.1_Missense_Mutation_p.S170F	NM_006798.3	NP_006789.2	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus	170					detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(1)|skin(2)	30						AAACCTCAAGGAGTACATAAA	0.428000													14	29					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6958555	6958555	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr18:6958555G>A	ENST00000389658.3	-	55	7978	c.7885C>T	c.(7885-7887)Cca>Tca	p.P2629S		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	2629	Laminin G-like 3.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCTCCCTCTGGAATTCCCCCG	0.463000													13	14					0	0	1	0	0
NIPAL4	348938	broad.mit.edu	37	5	156899411	156899411	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:156899411G>A	ENST00000311946.7	+	6	960	c.844G>A	c.(844-846)Ggg>Agg	p.G282R	ADAM19_ENST00000430702.2_Intron|NIPAL4_ENST00000435489.2_Missense_Mutation_p.G263R	NM_001099287.1	NP_001092757.1	Q0D2K0	NIPA4_HUMAN	NIPA-like domain containing 4	282						integral to membrane	receptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(1)|lung(12)|prostate(1)|skin(1)	22						CCCACGTTACGGGCAAAGGAA	0.507000											OREG0016979	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	52	85					0	0	1	0	0
AGBL5	60509	broad.mit.edu	37	2	27276294	27276294	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:27276294G>A	ENST00000360131.4	+	3	399	c.240G>A	c.(238-240)cgG>cgA	p.R80R	AGBL5_ENST00000323064.8_Silent_p.R80R	NM_021831.5	NP_068603.4	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5	80					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|pancreas(1)|prostate(2)|skin(1)	28	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCAGCGTCCGGGGAGGAATGC	0.527000													18	35					0	0	1	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18956058	18956058	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:18956058G>A	ENST00000302797.3	-	1	498	c.274C>T	c.(274-276)Cat>Tat	p.H92Y	MRGPRX1_ENST00000526914.1_5'UTR	NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	92					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						GAGATGGTATGGGGGATACTG	0.517000													29	53					0	0	1	0	0
ADCY5	111	broad.mit.edu	37	3	123021960	123021960	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:123021960C>T	ENST00000462833.1	-	14	3878	c.2666G>A	c.(2665-2667)aGc>aAc	p.S889N	ADCY5_ENST00000309879.5_Missense_Mutation_p.S539N|ADCY5_ENST00000491190.1_Missense_Mutation_p.S522N	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	889					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		ATCGCCCAGGCTGTAGTTGAC	0.642000													14	24					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23523410	23523410	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:23523410G>A	ENST00000296682.3	+	9	1075	c.893G>A	c.(892-894)gGg>gAg	p.G298E		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	298	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						ATCACCAAGGGGAGAAACTGC	0.438000										HNSCC(3;0.000094)			10	20					0	0	1	0	0
CDYL2	124359	broad.mit.edu	37	16	80718716	80718716	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr16:80718716G>A	ENST00000299564.8	-	2	490	c.335C>T	c.(334-336)cCc>cTc	p.P112L	CDYL2_ENST00000566173.1_Missense_Mutation_p.P112L|CDYL2_ENST00000562753.1_5'UTR|CDYL2_ENST00000563890.1_Missense_Mutation_p.P112L|CDYL2_ENST00000562812.1_Missense_Mutation_p.P112L	NM_152342.2	NP_689555.2	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	112						nucleus	catalytic activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	21						CTTGGCCAGGGGAGGGTTAAT	0.552000													11	9					0	0	1	0	0
OXSR1	9943	broad.mit.edu	37	3	38278380	38278380	+	Silent	SNP	A	A	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:38278380A>G	ENST00000311806.3	+	11	1374	c.1002A>G	c.(1000-1002)ggA>ggG	p.G334G	OXSR1_ENST00000446845.1_Silent_p.G334G	NM_005109.2	NP_005100.1	O95747	OXSR1_HUMAN	oxidative stress responsive 1	334					intracellular protein kinase cascade|response to oxidative stress		ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		CAGAGGATGGAGGCTGGGAGT	0.423000													30	36					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135429310	135429310	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:135429310C>T	ENST00000394143.1	+	6	3736	c.3445C>T	c.(3445-3447)Ccc>Tcc	p.P1149S	GPR112_ENST00000412101.1_Missense_Mutation_p.P944S|GPR112_ENST00000394141.1_Missense_Mutation_p.P944S|GPR112_ENST00000370652.1_Missense_Mutation_p.P1149S|GPR112_ENST00000287534.4_Missense_Mutation_p.P1086S	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1149					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CTCAAAACCTCCCCCTGACAA	0.483000													28	9					0	0	1	0	0
PPA1	5464	broad.mit.edu	37	10	71973281	71973281	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:71973281C>T	ENST00000373232.2	-	6	548	c.449G>A	c.(448-450)gGg>gAg	p.G150E	PPA1_ENST00000373230.4_Missense_Mutation_p.G150E	NM_021129.3	NP_066952.1	Q15181	IPYR_HUMAN	pyrophosphatase (inorganic) 1	150					diphosphate metabolic process|tRNA aminoacylation for protein translation	cytosol	inorganic diphosphatase activity|magnesium ion binding			breast(2)|endometrium(1)|large_intestine(2)|lung(3)|skin(2)	10						GTCGGTTTCCCCTTCGTCAAT	0.383000													26	32					0	0	1	0	0
PTPN23	25930	broad.mit.edu	37	3	47452966	47452966	+	Silent	SNP	C	C	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:47452966C>G	ENST00000265562.4	+	20	3755	c.3678C>G	c.(3676-3678)gtC>gtG	p.V1226V	PTPN23_ENST00000431726.1_Silent_p.V1100V	NM_015466.2	NP_056281.1	Q9H3S7	PTN23_HUMAN	protein tyrosine phosphatase, non-receptor type 23	1226	Tyrosine-protein phosphatase.				cilium morphogenesis	cilium|cytoplasmic membrane-bounded vesicle|microtubule basal body	protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|large_intestine(5)|lung(7)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	23				BRCA - Breast invasive adenocarcinoma(193;0.000271)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		ACCAGGATGTCATGCCCTATG	0.602000													17	47					0	0	1	0	0
GPR83	10888	broad.mit.edu	37	11	94113639	94113639	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:94113639G>A	ENST00000243673.2	-	4	1119	c.948C>T	c.(946-948)tcC>tcT	p.S316S	GPR83_ENST00000539203.2_Silent_p.S274S	NM_016540.3	NP_057624.3	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83	316						integral to membrane|plasma membrane	neuropeptide Y receptor activity			NS(1)|breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)	19		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TGACCTTGCTGGACAGGAGGA	0.532000													25	26					0	0	1	0	0
SYNPR	132204	broad.mit.edu	37	3	63600983	63600983	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:63600983G>A	ENST00000478300.1	+	6	1095	c.684G>A	c.(682-684)caG>caA	p.Q228Q	SYNPR_ENST00000465156.1_Silent_p.Q144Q|SYNPR_ENST00000479198.1_3'UTR|SYNPR_ENST00000460711.1_Silent_p.Q219Q|SYNPR_ENST00000295894.5_Silent_p.Q208Q	NM_001130003.1	NP_001123475.1	Q8TBG9	SYNPR_HUMAN	synaptoporin	208	5 X approximate repeats.					cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	transporter activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	8				BRCA - Breast invasive adenocarcinoma(55;0.000918)|KIRC - Kidney renal clear cell carcinoma(15;0.0658)|Kidney(15;0.0904)		CTTCGGGACAGAGATATCTTT	0.453000													5	5					0	0	1	0	0
BRPF3	27154	broad.mit.edu	37	6	36168987	36168987	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:36168987C>T	ENST00000357641.6	+	2	1141	c.888C>T	c.(886-888)atC>atT	p.I296I	BRPF3_ENST00000339717.7_Silent_p.I296I|BRPF3_ENST00000534400.1_Silent_p.I296I|BRPF3_ENST00000443324.2_Silent_p.I296I|BRPF3_ENST00000543502.1_Silent_p.I296I|BRPF3_ENST00000534694.1_Silent_p.I296I	NM_015695.2	NP_056510.2	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	296					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	40						CCATCTGGATCCCTGAAGTCT	0.547000													16	24					0	0	1	0	0
CPNE7	27132	broad.mit.edu	37	16	89653081	89653081	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr16:89653081C>T	ENST00000268720.5	+	10	1139	c.1009C>T	c.(1009-1011)Cag>Tag	p.Q337*	CPNE7_ENST00000319518.8_Nonsense_Mutation_p.Q262*	NM_014427.4	NP_055242.1	Q9UBL6	CPNE7_HUMAN	copine VII	337					lipid metabolic process		transporter activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(2)	17		all_hematologic(23;0.0748)		all cancers(4;3.63e-08)|OV - Ovarian serous cystadenocarcinoma(4;1.7e-06)|BRCA - Breast invasive adenocarcinoma(80;0.0147)		GCCCCAGGCCCAGTGGGACTG	0.587000													24	5					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227872279	227872279	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:227872279C>T	ENST00000396625.3	-	48	5042	c.4835G>A	c.(4834-4836)gGa>gAa	p.G1612E	COL4A4_ENST00000329662.7_Missense_Mutation_p.G1609E	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1612	Collagen IV NC1.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GGCCTGCCCTCCTCCTTGGTC	0.562000													16	24					0	0	1	0	0
ONECUT1	3175	broad.mit.edu	37	15	53049957	53049957	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:53049957C>T	ENST00000305901.5	-	2	1320	c.1193G>A	c.(1192-1194)cGa>cAa	p.R398Q	ONECUT1_ENST00000560699.2_Missense_Mutation_p.E39K|ONECUT1_ENST00000561401.2_5'UTR	NM_004498.2	NP_004489.1	Q9UBC0	HNF6_HUMAN	one cut homeobox 1	398					endocrine pancreas development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|prostate(2)|skin(1)	17				all cancers(107;0.0708)		ATGTAGAGTTCGACGCTGGAC	0.463000													51	106					0	0	1	0	0
CIDEB	27141	broad.mit.edu	37	14	24776700	24776700	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:24776700C>T	ENST00000336557.5	-	5	1365	c.63G>A	c.(61-63)tcG>tcA	p.S21S	NOP9_ENST00000267425.3_3'UTR|CIDEB_ENST00000258807.5_Silent_p.S21S|CIDEB_ENST00000554411.1_Silent_p.S21S			Q9UHD4	CIDEB_HUMAN	cell death-inducing DFFA-like effector b	21					apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis	cytosol				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|urinary_tract(1)	7				GBM - Glioblastoma multiforme(265;0.0181)		GTCCAAACTCCGAGCTTATAT	0.552000													17	38					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9064566	9064566	+	Missense_Mutation	SNP	G	G	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:9064566G>T	ENST00000397910.4	-	3	23083	c.22880C>A	c.(22879-22881)cCt>cAt	p.P7627H		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7629	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGACTCCGAAGGACCTGTTTG	0.463000													22	25					3.10358e-05	3.12793e-05	1	1	0
LLGL2	3993	broad.mit.edu	37	17	73566171	73566171	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:73566171C>T	ENST00000392550.3	+	15	1826	c.1709C>T	c.(1708-1710)cCc>cTc	p.P570L	LLGL2_ENST00000167462.5_Missense_Mutation_p.P570L|LLGL2_ENST00000577200.1_Missense_Mutation_p.P570L	NM_001031803.1	NP_001026973.1	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 (Drosophila)	570					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			NS(1)|breast(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			CGCTCAGGGCCCGTGCGCTTT	0.687000													3	14					0	0	1	0	0
RASSF9	9182	broad.mit.edu	37	12	86198821	86198821	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:86198821C>G	ENST00000361228.3	-	2	1335	c.967G>C	c.(967-969)Gag>Cag	p.E323Q		NM_005447.3	NP_005438.2	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family (N-terminal) member 9	323					endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						ATGCTTTTCTCCAAATCACAC	0.373000													46	89					0	0	1	0	0
DNMT3B	1789	broad.mit.edu	37	20	31393192	31393192	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:31393192G>A	ENST00000328111.2	+	21	2601	c.2280G>A	c.(2278-2280)ttG>ttA	p.L760L	DNMT3B_ENST00000456297.2_Intron|DNMT3B_ENST00000353855.2_Silent_p.L740L|DNMT3B_ENST00000348286.2_Intron|DNMT3B_ENST00000201963.3_Silent_p.L752L|DNMT3B_ENST00000443239.3_Intron|DNMT3B_ENST00000344505.4_Silent_p.L740L	NM_006892.3	NP_008823.1	Q9UBC3	DNM3B_HUMAN	DNA (cytosine-5-)-methyltransferase 3 beta	760					negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(16)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						AGGACTGCTTGGAATACAATA	0.493000													13	27					0	0	1	0	0
CLEC4F	165530	broad.mit.edu	37	2	71043813	71043813	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:71043813C>T	ENST00000272367.2	-	4	776	c.700G>A	c.(700-702)Gaa>Aaa	p.E234K	CLEC4F_ENST00000426626.1_Missense_Mutation_p.E234K	NM_001258027.1|NM_173535.2	NP_001244956.1|NP_775806.2	Q8N1N0	CLC4F_HUMAN	C-type lectin domain family 4, member F	234					endocytosis	integral to membrane	receptor activity|sugar binding			endometrium(1)|large_intestine(5)|lung(18)|ovary(5)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	37						TTTGCCGTTTCCAAACTGGCA	0.408000													22	19					0	0	1	0	0
STAT1	6772	broad.mit.edu	37	2	191848400	191848400	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:191848400G>A	ENST00000361099.3	-	17	1801	c.1414C>T	c.(1414-1416)Ctt>Ttt	p.L472F	STAT1_ENST00000392323.2_Missense_Mutation_p.L474F|STAT1_ENST00000392322.3_Missense_Mutation_p.L472F|STAT1_ENST00000540176.1_3'UTR|STAT1_ENST00000409465.1_Missense_Mutation_p.L472F	NM_007315.3	NP_009330.1	P42224	STAT1_HUMAN	signal transducer and activator of transcription 1, 91kDa	472					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	TTGTACCAAAGGATGGAGGCC	0.537000													14	56					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33587427	33587427	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:33587427G>A	ENST00000262873.7	+	35	4812	c.4720G>A	c.(4720-4722)Gaa>Aaa	p.E1574K		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	1532						membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			GAGCATCCAGGAACTGGAGAA	0.607000													8	11					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53092783	53092783	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:53092783A>T	ENST00000276480.7	-	9	859	c.176T>A	c.(175-177)aTg>aAg	p.M59K		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	59						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TCGGGGCTTCATTAGCAGGGA	0.507000													30	66					0	0	1	0	0
YARS	8565	broad.mit.edu	37	1	33272179	33272179	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:33272179G>A	ENST00000373477.4	-	4	1322	c.414C>T	c.(412-414)tcC>tcT	p.S138S		NM_003680.3	NP_003671.1	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	138					apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|skin(2)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	GTGTGACCACGGAGGAGAGTC	0.532000													27	42					0	0	1	0	0
ZSCAN21	7589	broad.mit.edu	37	7	99654900	99654900	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:99654900G>A	ENST00000292450.4	+	2	435	c.271G>A	c.(271-273)Gag>Aag	p.E91K	ZSCAN21_ENST00000477297.1_3'UTR|ZSCAN21_ENST00000456748.2_Missense_Mutation_p.E91K|ZSCAN21_ENST00000543588.1_Missense_Mutation_p.E91K	NM_145914.2	NP_666019.1	Q9Y5A6	ZSC21_HUMAN	zinc finger and SCAN domain containing 21	91	SCAN box.				positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|skin(1)	21	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			ACTGGTGCTGGAGCAGTTCCT	0.632000													45	16					0	0	1	0	0
KCNV1	27012	broad.mit.edu	37	8	110980496	110980496	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:110980496C>T	ENST00000524391.1	-	4	2356	c.1324G>A	c.(1324-1326)Gaa>Aaa	p.E442K	KCNV1_ENST00000297404.1_Missense_Mutation_p.E442K			Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	442						voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(20)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			ACAGCTGCTTCCTTGAGTTTC	0.433000													23	27					0	0	1	0	0
FAN1	22909	broad.mit.edu	37	15	31221449	31221449	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:31221449G>A	ENST00000362065.4	+	12	2927	c.2636G>A	c.(2635-2637)aGa>aAa	p.R879K	FAN1_ENST00000568145.1_3'UTR	NM_014967.4	NP_055782.3	Q9Y2M0	FAN1_HUMAN	FANCD2/FANCI-associated nuclease 1	879					double-strand break repair via homologous recombination|nucleotide-excision repair, DNA incision	nucleus	5'-3' exonuclease activity|5'-flap endonuclease activity|DNA binding|magnesium ion binding|phosphodiesterase I activity|ubiquitin binding			autonomic_ganglia(2)|breast(2)|cervix(2)|endometrium(7)|kidney(1)|large_intestine(6)|lung(8)|skin(1)	29						TTCACAAGCAGACGCCCAGCC	0.607000								Direct reversal of damage					4	100					0	0	1	0	0
CCDC63	160762	broad.mit.edu	37	12	111291243	111291243	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:111291243C>T	ENST00000308208.5	+	3	286	c.44C>T	c.(43-45)cCc>cTc	p.P15L	CCDC63_ENST00000552694.1_Intron|CCDC63_ENST00000550317.1_Intron|CCDC63_ENST00000545036.1_5'UTR	NM_152591.1	NP_689804.1	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	15										NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(1)	39						TCCGACACTCCCCAGGAACCT	0.577000													13	15					0	0	1	0	0
RGS3	5998	broad.mit.edu	37	9	116356774	116356774	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:116356774C>T	ENST00000374140.2	+	23	3354	c.3145C>T	c.(3145-3147)Ccc>Tcc	p.P1049S	RGS3_ENST00000342620.5_Missense_Mutation_p.P19S|RGS3_ENST00000374134.3_Missense_Mutation_p.P370S|RGS3_ENST00000350696.5_Missense_Mutation_p.P1049S|RGS3_ENST00000343817.5_Missense_Mutation_p.P768S|RGS3_ENST00000462403.1_Missense_Mutation_p.P162S|RGS3_ENST00000394646.3_Missense_Mutation_p.P442S|RGS3_ENST00000462143.1_Missense_Mutation_p.P370S	NM_144488.4	NP_652759.3	P49796	RGS3_HUMAN	regulator of G-protein signaling 3	1049					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			cervix(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	48						TGGAGCCCCTCCCGCGGGCAA	0.587000													19	14					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43912675	43912675	+	Missense_Mutation	SNP	A	A	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:43912675A>T	ENST00000562955.1	+	65	8951	c.8951A>T	c.(8950-8952)cAc>cTc	p.H2984L	SZT2_ENST00000372442.1_Missense_Mutation_p.H2142L	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	3041						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						GACCTGATGCACGTGCACTCG	0.597000													9	8					0	0	1	0	0
MPP7	143098	broad.mit.edu	37	10	28345478	28345478	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:28345478C>T	ENST00000337532.5	-	17	1758	c.1482G>A	c.(1480-1482)ttG>ttA	p.L494L	MPP7_ENST00000540098.1_Silent_p.L494L|MPP7_ENST00000375732.1_Silent_p.L494L|MPP7_ENST00000375719.3_Silent_p.L494L	NM_173496.3	NP_775767.2	Q5T2T1	MPP7_HUMAN	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	494	Guanylate kinase-like.				establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|stomach(1)	22						TTGTTTCTCTCAAACGCTCTA	0.378000													28	58					0	0	1	0	0
DAPK1	1612	broad.mit.edu	37	9	90301555	90301555	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:90301555G>A	ENST00000469640.2	+	21	2689	c.2314G>A	c.(2314-2316)Ggg>Agg	p.G772R	DAPK1_ENST00000491893.1_Missense_Mutation_p.G772R|DAPK1_ENST00000472284.1_Missense_Mutation_p.G772R|DAPK1_ENST00000358077.5_Missense_Mutation_p.G772R|DAPK1_ENST00000408954.3_Missense_Mutation_p.G772R			P53355	DAPK1_HUMAN	death-associated protein kinase 1	772					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(27)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(3)|stomach(1)	72						TCTTACCAAAGGGATGCTGGA	0.582000									Chronic Lymphocytic Leukemia, Familial Clustering of				6	2					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	43986071	43986071	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr22:43986071G>C	ENST00000262726.7	-	24	3168	c.2915C>G	c.(2914-2916)gCa>gGa	p.A972G	EFCAB6_ENST00000396231.2_Missense_Mutation_p.A820G	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	972	EF-hand 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				TTTGGTGAATGCTTTGCTGAT	0.413000													19	28					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	166924574	166924574	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:166924574G>A	ENST00000061240.2	+	6	1311	c.664G>A	c.(664-666)Gga>Aga	p.G222R	TLL1_ENST00000513213.1_Missense_Mutation_p.G222R|TLL1_ENST00000507499.1_Missense_Mutation_p.G222R	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	222	Metalloprotease (By similarity).				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		GCGAGGAAATGGACCTCAGGC	0.448000													15	7					0	0	1	0	0
KIF25	3834	broad.mit.edu	37	6	168440834	168440834	+	Missense_Mutation	SNP	C	C	T	rs139367341	by1000genomes	TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:168440834C>T	ENST00000443060.2	+	7	975	c.584C>T	c.(583-585)tCc>tTc	p.S195F	KIF25_ENST00000354419.2_Missense_Mutation_p.S195F|KIF25_ENST00000351261.3_Missense_Mutation_p.S195F			Q9UIL4	KIF25_HUMAN	kinesin family member 25	195	Kinesin-motor.				microtubule-based movement|mitotic sister chromatid segregation	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		CACGCGGATTCCTCCAGGTCT	0.557000													13	16					0	0	1	0	0
RPS6KA5	9252	broad.mit.edu	37	14	91369249	91369249	+	Missense_Mutation	SNP	T	T	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:91369249T>C	ENST00000261991.3	-	9	1195	c.1022A>G	c.(1021-1023)gAt>gGt	p.D341G	RPS6KA5_ENST00000418736.2_Missense_Mutation_p.D341G|RPS6KA5_ENST00000536315.2_Missense_Mutation_p.D262G	NM_004755.2	NP_004746.2	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 5	341	AGC-kinase C-terminal.				axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	24		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		ATCTAATTCATCTCGAATGAC	0.408000													18	20					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189590656	189590656	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:189590656C>T	ENST00000264731.3	+	10	1310	c.1221C>T	c.(1219-1221)ggC>ggT	p.G407G	TP63_ENST00000392461.3_Silent_p.G313G|TP63_ENST00000392460.3_Silent_p.G407G|TP63_ENST00000354600.5_Silent_p.G313G|TP63_ENST00000418709.2_Silent_p.G407G|TP63_ENST00000382063.4_Silent_p.G322G|TP63_ENST00000456148.1_Silent_p.G309G|TP63_ENST00000437221.1_Silent_p.G313G|TP63_ENST00000440651.2_Silent_p.G403G|TP63_ENST00000449992.1_Silent_p.G228G|TP63_ENST00000320472.5_Silent_p.G407G|TP63_ENST00000392463.2_Silent_p.G313G	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	407	Oligomerization.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		AGGTGAGGGGCCGTGAGACTT	0.443000										HNSCC(45;0.13)			16	15					0	0	1	0	0
C14orf37	145407	broad.mit.edu	37	14	58563470	58563470	+	Silent	SNP	G	G	A	rs111628716		TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:58563470G>A	ENST00000267485.7	-	5	2255	c.2061C>T	c.(2059-2061)ctC>ctT	p.L687L		NM_001001872.2	NP_001001872.2	Q86TY3	CN037_HUMAN	chromosome 14 open reading frame 37	687						integral to membrane	binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|skin(1)	33						GTTCCCACTCGAGGGCATCTG	0.512000													5	18					0	0	1	0	0
OPLAH	26873	broad.mit.edu	37	8	145111547	145111547	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:145111547C>T	ENST00000426825.1	-	13	1899	c.1818G>A	c.(1816-1818)ggG>ggA	p.G606G	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	606							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	CCCCGAAGTCCCCCGCACGGG	0.672000													12	29					0	0	1	0	0
ALX4	60529	broad.mit.edu	37	11	44297015	44297015	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:44297015G>A	ENST00000329255.3	-	2	763	c.660C>T	c.(658-660)acC>acT	p.T220T		NM_021926.3	NP_068745.2	Q9H161	ALX4_HUMAN	ALX homeobox 4	220					hair follicle development					central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	16						AGCTGGTGAAGGTGGTCCGGT	0.622000													61	74					0	0	1	0	0
IL1A	3552	broad.mit.edu	37	2	113539379	113539379	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:113539379C>T	ENST00000263339.3	-	4	276	c.121G>A	c.(121-123)Ggc>Agc	p.G41S		NM_000575.3	NP_000566.3	P01583	IL1A_HUMAN	interleukin 1, alpha	41					anti-apoptosis|apoptosis|cell proliferation|cellular response to heat|cytokine-mediated signaling pathway|fever generation|immune response|negative regulation of cell proliferation|positive regulation of angiogenesis|positive regulation of cell division|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation vascular endothelial growth factor production|response to copper ion	cytosol|extracellular space	copper ion binding|cytokine activity|interleukin-1 receptor binding			breast(2)|large_intestine(1)|lung(9)	12						TGGAGTGGGCCATAGCTTACA	0.443000													11	27					0	0	1	0	0
OR5R1	219479	broad.mit.edu	37	11	56185427	56185427	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:56185427G>A	ENST00000312253.1	-	1	281	c.282C>T	c.(280-282)ttC>ttT	p.F94F		NM_001004744.1	NP_001004744.1	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R, member 1	94					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(17)|ovary(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(21;0.00448)					CACAAGCATGGAAAGGAATGG	0.463000													9	7					0	0	1	0	0
PODN	127435	broad.mit.edu	37	1	53544220	53544220	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:53544220G>A	ENST00000371500.3	+	10	1466	c.1125G>A	c.(1123-1125)cgG>cgA	p.R375R	PODN_ENST00000395871.2_Silent_p.R252R|PODN_ENST00000312553.5_Silent_p.R394R|RP11-334A14.5_ENST00000447867.1_RNA	NM_001199080.1	NP_001186009.1	Q7Z5L7	PODN_HUMAN	podocan	346					negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						ACCAGCTGCGGGAGCAGGGCA	0.652000													10	28					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1459998	1459998	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:1459998G>A	ENST00000345913.4	+	7	854	c.763G>A	c.(763-765)Gga>Aga	p.G255R	TPO_ENST00000497517.2_Intron|TPO_ENST00000337415.3_Missense_Mutation_p.G255R|TPO_ENST00000329066.4_Missense_Mutation_p.G255R|TPO_ENST00000382201.3_Missense_Mutation_p.G255R|TPO_ENST00000349624.3_Missense_Mutation_p.G255R|TPO_ENST00000382198.1_Missense_Mutation_p.G255R|TPO_ENST00000346956.3_Missense_Mutation_p.G255R	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	255					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	TGCCTTCGGGGGAGGGGCTGA	0.473000													6	19					0	0	1	0	0
OR3A3	8392	broad.mit.edu	37	17	3324457	3324457	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:3324457C>T	ENST00000291231.1	+	1	596	c.596C>T	c.(595-597)tCc>tTc	p.S199F		NM_012373.2	NP_036505.2	P47888	OR3A3_HUMAN	olfactory receptor, family 3, subfamily A, member 3	199					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(3)|prostate(1)	9						CTCTCCTGCTCCAGCACCCAA	0.552000													22	46					0	0	1	0	0
FBF1	85302	broad.mit.edu	37	17	73915929	73915929	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:73915929G>A	ENST00000586717.1	-	19	2189	c.1916C>T	c.(1915-1917)tCg>tTg	p.S639L	FBF1_ENST00000319129.5_Missense_Mutation_p.S638L|FBF1_ENST00000389570.4_Missense_Mutation_p.S639L			A6NLR5	A6NLR5_HUMAN	Fas (TNFRSF6) binding factor 1	638										large_intestine(2)|ovary(1)|upper_aerodigestive_tract(1)	4						TTGCTGGTACGATGTTTCTAG	0.612000													28	26					0	0	1	0	0
XRN1	54464	broad.mit.edu	37	3	142141539	142141539	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:142141539C>A	ENST00000264951.4	-	8	969	c.852G>T	c.(850-852)ttG>ttT	p.L284F	XRN1_ENST00000392981.2_Missense_Mutation_p.L284F|XRN1_ENST00000544157.1_Missense_Mutation_p.L74F|XRN1_ENST00000463916.1_Missense_Mutation_p.L284F	NM_019001.3	NP_061874.3	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1	284					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(6)|kidney(12)|large_intestine(11)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	61						GAAACCCCATCAAAATCCAAT	0.318000													19	22					8.34094e-07	8.42843e-07	1	1	0
SFTPD	6441	broad.mit.edu	37	10	81701731	81701731	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:81701731G>A	ENST00000372292.3	-	5	569	c.529C>T	c.(529-531)Cct>Tct	p.P177S		NM_003019.4	NP_003010.4	P35247	SFTPD_HUMAN	surfactant protein D	177	Collagen-like.				cell junction assembly|innate immune response|lung alveolus development|macrophage chemotaxis|negative regulation of interleukin-2 biosynthetic process|negative regulation of T cell proliferation|positive regulation of phagocytosis|reactive oxygen species metabolic process|receptor-mediated endocytosis|respiratory gaseous exchange|surfactant homeostasis	collagen|endocytic vesicle|extracellular space|lysosome	bacterial cell surface binding|protein binding|sugar binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(3)|skin(4)|urinary_tract(1)	17	Breast(12;0.000615)|Prostate(51;0.0095)|all_epithelial(25;0.027)		Epithelial(14;0.0244)|all cancers(16;0.0558)|Colorectal(32;0.109)			GTGTTTCCAGGGACTCCACGC	0.637000													25	48					0	0	1	0	0
OAZ3	51686	broad.mit.edu	37	1	151742727	151742727	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:151742727G>A	ENST00000315067.8	+	5	591	c.424G>A	c.(424-426)Gac>Aac	p.D142N	OAZ3_ENST00000400999.1_Silent_p.T4T|OAZ3_ENST00000453029.2_Missense_Mutation_p.D155N|OAZ3_ENST00000321531.5_Missense_Mutation_p.D142N|OAZ3_ENST00000479764.1_Silent_p.T4T			Q9UMX2	OAZ3_HUMAN	ornithine decarboxylase antizyme 3	139					cellular nitrogen compound metabolic process|regulation of cellular amino acid metabolic process|spermatogenesis	cytosol|nucleus	ornithine decarboxylase inhibitor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(4)	9	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)		L-Ornithine(DB00129)	TGATCGGAACGACAGAGGTGG	0.473000													40	78					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175355367	175355367	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:175355367G>A	ENST00000367674.1	-	8	2286	c.1578C>T	c.(1576-1578)ccC>ccT	p.P526P	TNR_ENST00000263525.2_Silent_p.P526P	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	526	Fibronectin type-III 3.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					TGGCTCGAGGGGGAATCCACT	0.542000													6	13					0	0	1	0	0
C1S	716	broad.mit.edu	37	12	7169808	7169808	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:7169808G>A	ENST00000406697.1	+	6	663	c.35G>A	c.(34-36)tGg>tAg	p.W12*	C1S_ENST00000402681.3_Intron|C1S_ENST00000328916.3_Nonsense_Mutation_p.W12*|C1S_ENST00000360817.5_Nonsense_Mutation_p.W12*			P09871	C1S_HUMAN	complement component 1, s subcomponent	12					complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	CTTTTGGCATGGGTTTATGCT	0.493000													14	22					0	0	1	0	0
PODN	127435	broad.mit.edu	37	1	53544219	53544219	+	Missense_Mutation	SNP	G	G	A	rs148954257	byFrequency	TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:53544219G>A	ENST00000371500.3	+	10	1465	c.1124G>A	c.(1123-1125)cGg>cAg	p.R375Q	PODN_ENST00000395871.2_Missense_Mutation_p.R252Q|PODN_ENST00000312553.5_Missense_Mutation_p.R394Q|RP11-334A14.5_ENST00000447867.1_RNA	NM_001199080.1	NP_001186009.1	Q7Z5L7	PODN_HUMAN	podocan	346					negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						AACCAGCTGCGGGAGCAGGGC	0.652000													9	28					0	0	1	0	0
IGLJ2	28832	broad.mit.edu	37	22	23241807	23241807	+	RNA	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr22:23241807C>T	ENST00000390322.2	+	0	147																											GTGTGGTATTCGGCGGAGGGA	0.562000													16	79					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228883943	228883943	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:228883943C>T	ENST00000392056.3	-	7	1673	c.1627G>A	c.(1627-1629)Gga>Aga	p.G543R	SPHKAP_ENST00000344657.5_Missense_Mutation_p.G543R	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	543						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TCCTTGAGTCCTTGGGGTGCT	0.527000													24	43					0	0	1	0	0
BDNF	627	broad.mit.edu	37	11	27679378	27679378	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:27679378C>T	ENST00000525528.1	-	1	1827	c.734G>A	c.(733-735)aGg>aAg	p.R245K	BDNF-AS_ENST00000532965.1_RNA|BDNF_ENST00000525950.1_Missense_Mutation_p.R245K|BDNF_ENST00000533131.1_Missense_Mutation_p.R245K|BDNF_ENST00000395978.3_Missense_Mutation_p.R245K|BDNF_ENST00000420794.1_Missense_Mutation_p.R245K|BDNF_ENST00000314915.6_Missense_Mutation_p.R253K|BDNF_ENST00000395980.2_Missense_Mutation_p.R245K|BDNF-AS_ENST00000499568.2_RNA|BDNF_ENST00000438929.1_Missense_Mutation_p.R327K|BDNF_ENST00000533246.1_Missense_Mutation_p.R245K|BDNF_ENST00000395983.3_Missense_Mutation_p.R245K|BDNF-AS_ENST00000530313.1_RNA|BDNF_ENST00000439476.2_Missense_Mutation_p.R245K|BDNF-AS_ENST00000530686.1_RNA|BDNF-AS_ENST00000499008.3_RNA|BDNF_ENST00000395986.2_Missense_Mutation_p.R260K|BDNF_ENST00000584049.1_5'UTR|BDNF_ENST00000395981.3_Missense_Mutation_p.R245K|BDNF-AS_ENST00000500662.2_RNA|BDNF_ENST00000530861.1_Missense_Mutation_p.R245K|BDNF-AS_ENST00000502161.2_RNA|BDNF_ENST00000532997.1_Missense_Mutation_p.R245K|BDNF-AS_ENST00000501176.2_RNA|BDNF_ENST00000356660.4_Missense_Mutation_p.R245K|BDNF_ENST00000418212.1_Missense_Mutation_p.R245K	NM_170735.5	NP_733931.1	P23560	BDNF_HUMAN	brain-derived neurotrophic factor	245						extracellular region	growth factor activity			breast(1)|large_intestine(3)|lung(2)	6						CTATCTTCCCCTTTTAATGGT	0.338000													23	48					0	0	1	0	0
MIDN	90007	broad.mit.edu	37	19	1254977	1254977	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:1254977C>T	ENST00000300952.2	+	6	1288	c.773C>T	c.(772-774)cCt>cTt	p.P258L	MIDN_ENST00000591446.2_Missense_Mutation_p.P258L	NM_177401.4	NP_796375.3	Q504T8	MIDN_HUMAN	midnolin	258						nucleolus				NS(1)|endometrium(3)|kidney(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGGCCAGCCCTGCCCCCCGC	0.652000													56	65					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:20414343A>G	ENST00000380338.4	-	5	787	c.501T>C	c.(499-501)agT>agC	p.S167S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S164S|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.532000			T	MLL	ALL								5	54					0	0	1	0	0
RNF165	494470	broad.mit.edu	37	18	44030261	44030261	+	Silent	SNP	C	C	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr18:44030261C>G	ENST00000269439.7	+	5	669	c.618C>G	c.(616-618)gtC>gtG	p.V206V	RNF165_ENST00000543885.1_Silent_p.V14V	NM_152470.2	NP_689683.2	Q6ZSG1	RN165_HUMAN	ring finger protein 165	206							zinc ion binding			NS(1)|large_intestine(4)|lung(6)	11				READ - Rectum adenocarcinoma(1;0.0873)		CCCAACAGGTCGTCCATGAAA	0.522000													18	20					0	0	1	0	0
PAH	5053	broad.mit.edu	37	12	103232983	103232983	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:103232983G>A	ENST00000553106.1	-	13	1801	c.1329C>T	c.(1327-1329)atC>atT	p.I443I	PAH_ENST00000307000.2_Silent_p.I438I	NM_000277.1	NP_000268.1	P00439	PH4H_HUMAN	phenylalanine hydroxylase	443					catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			endometrium(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(5)|skin(2)|urinary_tract(1)	27					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	CACTGCAAAGGATTCCAATTT	0.403000													9	20					0	0	1	0	0
CERKL	375298	broad.mit.edu	37	2	182412343	182412343	+	Splice_Site	SNP	A	A	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:182412343A>G	ENST00000410087.3	-	10	1369		c.e10+1		CERKL_ENST00000374970.2_Splice_Site|CERKL_ENST00000409440.3_Splice_Site|CERKL_ENST00000479558.1_Splice_Site|CERKL_ENST00000374969.2_Splice_Site|CERKL_ENST00000339098.5_Splice_Site	NM_001030311.2|NM_201548.4	NP_001025482.1|NP_963842.1	Q49MI3	CERKL_HUMAN	ceramide kinase-like						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|Golgi apparatus|nucleolus	diacylglycerol kinase activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(13)|ovary(3)|skin(3)	32			OV - Ovarian serous cystadenocarcinoma(117;0.088)			ATGCTTACTAACCTGGTATTA	0.388000													15	24					0	0	1	0	0
ATXN7L2	127002	broad.mit.edu	37	1	110032592	110032592	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:110032592C>T	ENST00000369870.3	+	8	1093	c.1078C>T	c.(1078-1080)Ccc>Tcc	p.P360S		NM_153340.4	NP_699171.3	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	360										breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)	17		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		TGATGAAGGCCCCTGTGGTGG	0.632000													47	87					0	0	1	0	0
OR10J1	26476	broad.mit.edu	37	1	159410425	159410425	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:159410425C>T	ENST00000423932.3	+	1	914	c.877C>T	c.(877-879)Ccc>Tcc	p.P293S	RP11-550P17.5_ENST00000431862.1_RNA	NM_012351.2	NP_036483.2	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J, member 1	293					sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|stomach(1)	25	all_hematologic(112;0.0429)					TGTCATCACTCCCCTACTGAA	0.507000													21	35					0	0	1	0	0
CHIT1	1118	broad.mit.edu	37	1	203192268	203192268	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:203192268G>A	ENST00000367229.1	-	6	634	c.600C>T	c.(598-600)atC>atT	p.I200I	CHIT1_ENST00000484834.1_Intron|CHIT1_ENST00000535569.1_Silent_p.I191I|CHIT1_ENST00000255427.3_Silent_p.I181I	NM_001270509.1|NM_003465.2	NP_001257438.1|NP_003456.1	Q13231	CHIT1_HUMAN	chitinase 1 (chitotriosidase)	200					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|stomach(2)	27						CTCACTGGGCGATTTTGTCCA	0.572000													52	67					0	0	1	0	0
SYCP1	6847	broad.mit.edu	37	1	115428173	115428173	+	Silent	SNP	T	T	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:115428173T>C	ENST00000369522.3	+	13	1168	c.928T>C	c.(928-930)Tta>Cta	p.L310L	SYCP1_ENST00000369518.1_Silent_p.L310L	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	310					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAGTGAAAACTTAAAACAATC	0.264000													10	18					0	0	1	0	0
HYAL3	8372	broad.mit.edu	37	3	50332308	50332308	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:50332308G>A	ENST00000336307.1	-	2	998	c.726C>T	c.(724-726)ttC>ttT	p.F242F	HYAL3_ENST00000513170.1_Intron|HYAL3_ENST00000359051.3_Silent_p.F242F|HYAL3_ENST00000450982.1_Silent_p.F242F|HYAL3_ENST00000415204.1_Intron	NM_001200029.1|NM_003549.3	NP_001186958.1|NP_003540.2	O43820	HYAL3_HUMAN	hyaluronoglucosaminidase 3	242					carbohydrate metabolic process	extracellular region|lysosome	hyalurononglucosaminidase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|lung(5)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		AGATGCTGGGGAAGAGGGCAC	0.642000													17	24					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87148690	87148690	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:87148690C>T	ENST00000265724.3	-	24	3296	c.2879G>A	c.(2878-2880)gGa>gAa	p.G960E	ABCB1_ENST00000543898.1_Missense_Mutation_p.G896E|ABCB1_ENST00000488737.2_5'UTR	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	960	ABC transmembrane type-1 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	CAAGTAGGCTCCAAACCGGAA	0.383000													10	36					0	0	1	0	0
HIF3A	64344	broad.mit.edu	37	19	46832714	46832714	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:46832714C>T	ENST00000339613.2	+	12	1778	c.1523C>T	c.(1522-1524)cCc>cTc	p.P508L	HIF3A_ENST00000377670.4_Missense_Mutation_p.P564L|HIF3A_ENST00000300862.3_Missense_Mutation_p.P562L|HIF3A_ENST00000244303.6_Missense_Mutation_p.P495L|AC007193.10_ENST00000596807.1_RNA|HIF3A_ENST00000600383.1_Missense_Mutation_p.P495L|HIF3A_ENST00000420102.2_Missense_Mutation_p.P513L|HIF3A_ENST00000472815.1_Intron			Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	564	ODD.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(14)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	33		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		GCATCCTCTCCCATGGCTGGG	0.662000													9	5					0	0	1	0	0
TRIM55	84675	broad.mit.edu	37	8	67062008	67062008	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:67062008C>T	ENST00000315962.4	+	5	1105	c.732C>T	c.(730-732)gtC>gtT	p.V244V	TRIM55_ENST00000276573.7_Silent_p.V244V|TRIM55_ENST00000353317.5_Silent_p.V244V|TRIM55_ENST00000350034.4_Intron	NM_184085.1	NP_908973.1	Q9BYV6	TRI55_HUMAN	tripartite motif containing 55	244						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	39		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			TGGAACATGTCCGTGCTCTGA	0.418000													14	58					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168175341	168175341	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:168175341G>A	ENST00000519560.1	-	20	2655	c.2236C>T	c.(2236-2238)Ctc>Ttc	p.L746F	SLIT3_ENST00000404867.3_Missense_Mutation_p.L746F|SLIT3_ENST00000332966.8_Missense_Mutation_p.L746F	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	746	LRRNT 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCTCTGGGGAGGGCGCGGAGC	0.617000													31	47					0	0	1	0	0
CHAT	1103	broad.mit.edu	37	10	50857580	50857580	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:50857580G>A	ENST00000395562.2	+	11	1632	c.1163G>A	c.(1162-1164)cGa>cAa	p.R388Q	CHAT_ENST00000455728.2_Missense_Mutation_p.R352Q|CHAT_ENST00000395559.2_Missense_Mutation_p.R352Q|CHAT_ENST00000337653.2_Missense_Mutation_p.R470Q|CHAT_ENST00000351556.3_Missense_Mutation_p.R352Q|CHAT_ENST00000339797.1_Missense_Mutation_p.R352Q	NM_001142933.1|NM_001142934.1	NP_001136405.1|NP_001136406.1	P28329	CLAT_HUMAN	choline O-acetyltransferase	470					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(11)|lung(34)|prostate(3)|urinary_tract(1)	56		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	AAGCTGATCCGAGCAGACTCC	0.617000													29	28					0	0	1	0	0
SLC39A4	55630	broad.mit.edu	37	8	145641348	145641348	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:145641348G>A	ENST00000276833.5	-	1	548	c.245C>T	c.(244-246)cCc>cTc	p.P82L	SLC39A4_ENST00000301305.3_Missense_Mutation_p.P107L	NM_017767.2	NP_060237.2	Q6P5W5	S39A4_HUMAN	solute carrier family 39 (zinc transporter), member 4	107						cytoplasmic membrane-bounded vesicle|integral to membrane|recycling endosome membrane	zinc ion transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	14	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;1.12e-40)|all cancers(56;8.17e-36)|BRCA - Breast invasive adenocarcinoma(115;0.0407)|Colorectal(110;0.055)			GGTGCCCTCGGGGTTGCTGAG	0.736000													14	4					0	0	1	0	0
TMPRSS6	164656	broad.mit.edu	37	22	37491995	37491995	+	Silent	SNP	G	G	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr22:37491995G>T	ENST00000381792.2	-	5	680	c.540C>A	c.(538-540)gtC>gtA	p.V180V	TMPRSS6_ENST00000346753.3_Silent_p.V189V|TMPRSS6_ENST00000406856.1_Silent_p.V180V|TMPRSS6_ENST00000406725.1_Silent_p.V180V|TMPRSS6_ENST00000442782.2_Silent_p.V189V			Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	189					angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(5)|central_nervous_system(4)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)	40						CCCTGTAGGGGACGGCAGCCG	0.637000													23	38					5.35356e-11	5.43824e-11	1	1	0
CYP1A1	1543	broad.mit.edu	37	15	75013610	75013610	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:75013610G>A	ENST00000379727.3	-	5	1294	c.1096C>T	c.(1096-1098)Ccc>Tcc	p.P366S	CYP1A1_ENST00000564596.1_Missense_Mutation_p.P105S|CYP1A1_ENST00000567032.1_Missense_Mutation_p.P366S|CYP1A1_ENST00000395048.2_Missense_Mutation_p.P366S|CYP1A1_ENST00000395049.4_Missense_Mutation_p.P366S			P04798	CP1A1_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 1	366					cellular lipid metabolic process|drug metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|vitamin D 24-hydroxylase activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|large_intestine(7)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34					Arsenic trioxide(DB01169)|Benzphetamine(DB00865)|Bleomycin(DB00290)|Chlorzoxazone(DB00356)|Dacarbazine(DB00851)|Dactinomycin(DB00970)|Esomeprazole(DB00736)|Estrone(DB00655)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Ginseng(DB01404)|Granisetron(DB00889)|Ketoconazole(DB01026)|Menadione(DB00170)|Picrotoxin(DB00466)|Primaquine(DB01087)|Quinidine(DB00908)|Quinine(DB00468)|Thiabendazole(DB00730)	TCCATATAGGGCAGATGGGAT	0.597000									Endometrial Cancer, Familial Clustering of;ACTH-independent macronodular adrenal hyperplasia				18	61					0	0	1	0	0
UGT2B15	7366	broad.mit.edu	37	4	69519901	69519901	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:69519901G>A	ENST00000338206.5	-	5	1176	c.1167C>T	c.(1165-1167)atC>atT	p.I389I		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	389					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										CCACCATAGGGATCCCATGGT	0.448000													33	83					0	0	1	0	0
CTSE	1510	broad.mit.edu	37	1	206328787	206328787	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:206328787C>T	ENST00000361052.3	+	7	987	c.869C>T	c.(868-870)tCc>tTc	p.S290F	CTSE_ENST00000358184.2_Missense_Mutation_p.S285F|CTSE_ENST00000432969.2_Intron|CTSE_ENST00000360218.2_Intron			P14091	CATE_HUMAN	cathepsin E	290					antigen processing and presentation of exogenous peptide antigen via MHC class II|digestion|proteolysis	endosome	aspartic-type endopeptidase activity			endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|skin(3)	16			BRCA - Breast invasive adenocarcinoma(75;0.0754)			ACAGGGACTTCCCTCATCACT	0.607000													13	32					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141794549	141794549	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:141794549G>A	ENST00000475668.2	+	63	7398	c.7344G>A	c.(7342-7344)acG>acA	p.T2448T	MGAM_ENST00000549489.2_Silent_p.T1552T			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1552					polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TGTTTCAGACGGGAGCAGATA	0.473000													13	30					0	0	1	0	0
FAS	355	broad.mit.edu	37	10	90770317	90770317	+	Missense_Mutation	SNP	G	G	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:90770317G>C	ENST00000355740.2	+	5	685	c.465G>C	c.(463-465)aaG>aaC	p.K155N	FAS_ENST00000357339.2_Missense_Mutation_p.K155N|FAS_ENST00000355279.2_Missense_Mutation_p.K155N|FAS_ENST00000352159.4_Missense_Mutation_p.K155N|FAS_ENST00000313771.5_3'UTR	NM_000043.4|NM_152871.2|NM_152872.2	NP_000034.1|NP_690610.1|NP_690611.1	P25445	TNR6_HUMAN	Fas cell surface death receptor	155					activation of caspase activity|activation of pro-apoptotic gene products|anti-apoptosis|cellular response to mechanical stimulus|positive regulation of necrotic cell death	cytosol|extracellular region|integral to membrane|soluble fraction	identical protein binding|kinase binding			breast(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.0161)		Colorectal(12;0.000136)|COAD - Colon adenocarcinoma(12;0.000193)		GAATCATCAAGGAATGCACAC	0.358000													16	19					0	0	1	0	0
SLC27A1	376497	broad.mit.edu	37	19	17611525	17611525	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:17611525C>T	ENST00000252595.7	+	10	1573	c.1476C>T	c.(1474-1476)gaC>gaT	p.D492D	SLC27A1_ENST00000442725.1_Silent_p.D492D|SLC27A1_ENST00000598424.1_Silent_p.D313D|SLC27A1_ENST00000598848.1_Intron|CTD-3131K8.2_ENST00000596643.1_lincRNA	NM_198580.1	NP_940982.1	Q6PCB7	S27A1_HUMAN	solute carrier family 27 (fatty acid transporter), member 1	492					cardiolipin biosynthetic process|fatty acid metabolic process|long-chain fatty acid transport|negative regulation of phospholipid biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidylethanolamine biosynthetic process|phosphatidylinositol biosynthetic process|phosphatidylserine biosynthetic process|transmembrane transport	endomembrane system|integral to membrane	fatty acid transporter activity|nucleotide binding	p.D492E(2)		breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						TGCCAGGTGACGTGCTAGTGA	0.657000													9	40					0	0	1	0	0
TP53BP2	7159	broad.mit.edu	37	1	223988497	223988497	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:223988497G>A	ENST00000391878.2	-	11	1622	c.854C>T	c.(853-855)cCa>cTa	p.P285L	TP53BP2_ENST00000498843.1_5'UTR|TP53BP2_ENST00000343537.7_Missense_Mutation_p.P414L	NM_005426.2	NP_005417.1	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2	408					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(2)	29				GBM - Glioblastoma multiforme(131;0.0958)		AGGGCCAACTGGATGGATTTT	0.398000													10	18					0	0	1	0	0
C10orf12	26148	broad.mit.edu	37	10	98741867	98741867	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:98741867C>T	ENST00000286067.2	+	1	827	c.720C>T	c.(718-720)gcC>gcT	p.A240A		NM_015652.2	NP_056467.2	Q8N655	CJ012_HUMAN	chromosome 10 open reading frame 12	240										NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(3)|prostate(2)|skin(2)|stomach(4)	45		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		CAATTCCAGCCCCTAGACATA	0.493000													11	36					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140175938	140175938	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:140175938C>T	ENST00000526136.1	+	1	1389	c.1389C>T	c.(1387-1389)ttC>ttT	p.F463F	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000378132.1_Silent_p.F463F|PCDHA2_ENST00000520672.2_Silent_p.F463F	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACACAGTATTCGTGAAGGAGA	0.647000													32	47					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20489930	20489930	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr16:20489930C>T	ENST00000573854.1	+	10	1326	c.1212C>T	c.(1210-1212)ccC>ccT	p.P404P	ACSM2A_ENST00000219054.6_Silent_p.P404P|ACSM2A_ENST00000417235.2_Silent_p.P325P|ACSM2A_ENST00000536134.1_Silent_p.P176P|ACSM2A_ENST00000396104.2_Silent_p.P404P|ACSM2A_ENST00000575558.1_3'UTR|ACSM2A_ENST00000575690.1_Silent_p.P404P	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	404					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						TCCTGCCCCCCGGCACAGAAG	0.507000													11	17					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18776857	18776857	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:18776857G>A	ENST00000380548.4	+	19	2969	c.2630G>A	c.(2629-2631)aGg>aAg	p.R877K		NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	877	Ig-like C2-type 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		CGCAGGCAGAGGAAGCTGCAC	0.687000													5	1					0	0	1	0	0
SLC35E1	79939	broad.mit.edu	37	19	16677451	16677451	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:16677451C>T	ENST00000409035.1	-	5	1489	c.1229G>A	c.(1228-1230)gGa>gAa	p.G410E	SLC35E1_ENST00000595753.1_Silent_p.R216R|SLC35E1_ENST00000431408.1_Silent_p.R60R																							GATGGTGGATCCGTGAATCTC	0.537000													47	48					0	0	1	0	0
COL28A1	340267	broad.mit.edu	37	7	7483233	7483233	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:7483233C>T	ENST00000399429.3	-	20	1773	c.1633G>A	c.(1633-1635)Gga>Aga	p.G545R		NM_001037763.2	NP_001032852.2	Q2UY09	COSA1_HUMAN	collagen, type XXVIII, alpha 1	545	Collagen-like 5.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	42		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		CCAGGCTGTCCTTTTCCAGGT	0.512000													10	27					0	0	1	0	0
ANKS4B	257629	broad.mit.edu	37	16	21262098	21262098	+	Missense_Mutation	SNP	A	A	C			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr16:21262098A>C	ENST00000311620.5	+	2	1284	c.1211A>C	c.(1210-1212)cAg>cCg	p.Q404P		NM_145865.2	NP_665872.2	Q8N8V4	ANS4B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 4B	404										NS(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|lung(11)|ovary(2)	20				GBM - Glioblastoma multiforme(48;0.0565)		AGGAGGAAGCAGGTGCTTCAA	0.557000													21	62					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28250509	28250509	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:28250509C>T	ENST00000305242.5	-	10	1466	c.1374G>A	c.(1372-1374)gtG>gtA	p.V458V	ARMC4_ENST00000537576.1_Silent_p.V150V|ARMC4_ENST00000239715.3_Silent_p.V315V|ARMC4_ENST00000480504.1_5'UTR|ARMC4_ENST00000545014.1_5'UTR	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	458							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						TTAAATATTTCACCAGCTTCT	0.378000													19	28					0	0	1	0	0
SGMS1	259230	broad.mit.edu	37	10	52103295	52103295	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr10:52103295G>A	ENST00000361781.2	-	7	1539	c.580C>T	c.(580-582)Ctt>Ttt	p.L194F	SGMS1_ENST00000429490.1_Intron|SGMS1_ENST00000361543.2_Missense_Mutation_p.L194F	NM_147156.3	NP_671512.1	Q86VZ5	SMS1_HUMAN	sphingomyelin synthase 1	200					apoptosis|cell growth|sphingomyelin biosynthetic process	endoplasmic reticulum|Golgi trans cisterna|integral to Golgi membrane|nucleus|plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	16						AGTCCTACAAGGATCATGCCA	0.413000													14	10					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41550967	41550967	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr21:41550967G>A	ENST00000400454.1	-	15	3311	c.2834C>T	c.(2833-2835)gCc>gTc	p.A945V		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	945	Fibronectin type-III 1.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				AATGATGGTGGCCGAGTTCAG	0.498000													7	24					0	0	1	0	0
FAM83C	128876	broad.mit.edu	37	20	33875363	33875363	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:33875363G>A	ENST00000374408.3	-	4	1315	c.1219C>T	c.(1219-1221)Cct>Tct	p.P407S		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	407										central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			TAGAGCCCAGGAGGGGAGCCG	0.627000													9	16					0	0	1	0	0
SENP1	29843	broad.mit.edu	37	12	48491775	48491775	+	Splice_Site	SNP	A	A	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:48491775A>G	ENST00000339976.6	-	3	614		c.e3+1		SENP1_ENST00000549595.1_Splice_Site|SENP1_ENST00000549518.1_Splice_Site|SENP1_ENST00000004980.5_Splice_Site|SENP1_ENST00000551330.1_Splice_Site|SENP1_ENST00000448372.1_Splice_Site			Q9P0U3	SENP1_HUMAN	SUMO1/sentrin specific peptidase 1						activation of caspase activity|induction of apoptosis by extracellular signals|protein desumoylation|proteolysis	cytoplasm|nucleus	endopeptidase activity|SUMO-specific protease activity			large_intestine(3)|lung(1)|pancreas(2)|stomach(1)	7		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)				ATTGCTCCTAACCTGCTGGTC	0.393000													8	11					0	0	1	0	0
WDR70	55100	broad.mit.edu	37	5	37396594	37396594	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:37396594C>T	ENST00000265107.4	+	5	570	c.414C>T	c.(412-414)atC>atT	p.I138I	WDR70_ENST00000504564.1_Silent_p.I138I	NM_018034.2	NP_060504.1	Q9NW82	WDR70_HUMAN	WD repeat domain 70	138										central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(18)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGGAAGATATCCTCGGTCCTT	0.403000													17	16					0	0	1	0	0
ECT2	1894	broad.mit.edu	37	3	172520438	172520438	+	Missense_Mutation	SNP	C	C	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:172520438C>G	ENST00000417960.1	+	19	2321	c.1844C>G	c.(1843-1845)gCt>gGt	p.A615G	ECT2_ENST00000427830.1_Missense_Mutation_p.A616G|ECT2_ENST00000540509.1_Missense_Mutation_p.A647G|ECT2_ENST00000441497.2_Missense_Mutation_p.A616G|ECT2_ENST00000232458.5_Missense_Mutation_p.A616G|ECT2_ENST00000392692.3_Missense_Mutation_p.A647G	NM_001258316.1	NP_001245245.1	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	616					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			AAAACAGAAGCTCAAAAGCAA	0.264000													6	17					0	0	1	0	0
UMODL1	89766	broad.mit.edu	37	21	43519064	43519064	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr21:43519064C>T	ENST00000400427.1	+	7	1140	c.744C>T	c.(742-744)gtC>gtT	p.V248V	UMODL1_ENST00000400424.1_Silent_p.V248V|UMODL1_ENST00000408910.2_Silent_p.V320V|UMODL1_ENST00000408989.2_Silent_p.V320V	NM_001199527.1	NP_001186456.1	Q5DID0	UROL1_HUMAN	uromodulin-like 1	320						cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						ACTACGTGGTCCTCAACGTCA	0.488000													34	56					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20994162	20994162	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr16:20994162G>A	ENST00000261383.3	-	49	7739	c.7740C>T	c.(7738-7740)ttC>ttT	p.F2580F	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2580	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TCAGCGAAGGGAACATCCGCA	0.493000													19	35					0	0	1	0	0
CYP2W1	54905	broad.mit.edu	37	7	1026358	1026358	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:1026358G>A	ENST00000340150.6	+	5	598	c.576G>A	c.(574-576)ctG>ctA	p.L192L	CYP2W1_ENST00000308919.7_Silent_p.L248L			Q8TAV3	CP2W1_HUMAN	cytochrome P450, family 2, subfamily W, polypeptide 1	248					xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			breast(1)|large_intestine(1)|lung(4)|urinary_tract(1)	7		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.74e-15)		GGACCCTCCTGGAGGCGCGGA	0.672000													11	17					0	0	1	0	0
SMARCA4	6597	broad.mit.edu	37	19	11143992	11143992	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:11143992C>T	ENST00000358026.2	+	26	3857	c.3573C>T	c.(3571-3573)caC>caT	p.H1191H	SMARCA4_ENST00000444061.3_Silent_p.H1191H|SMARCA4_ENST00000344626.4_Silent_p.H1191H|SMARCA4_ENST00000413806.3_Silent_p.H1191H|SMARCA4_ENST00000541122.2_Silent_p.H1191H|SMARCA4_ENST00000590574.1_Silent_p.H1191H|SMARCA4_ENST00000429416.3_Silent_p.H1191H|SMARCA4_ENST00000589677.1_Silent_p.H1191H|SMARCA4_ENST00000450717.3_Silent_p.H1191H	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	1191	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				ACCGAGCCCACCGCATCGGGC	0.612000			"""F, N, Mis"""		NSCLC								54	70					0	0	1	0	0
TMPRSS3	64699	broad.mit.edu	37	21	43809058	43809058	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr21:43809058C>T	ENST00000291532.3	-	4	1257	c.302G>A	c.(301-303)gGg>gAg	p.G101E	TMPRSS3_ENST00000433957.2_Missense_Mutation_p.G101E|TMPRSS3_ENST00000398397.3_Missense_Mutation_p.G101E|TMPRSS3_ENST00000398405.1_Missense_Mutation_p.G99E|TMPRSS3_ENST00000474596.1_5'UTR|TMPRSS3_ENST00000380399.1_Missense_Mutation_p.G185E	NM_032404.2	NP_115780.1	P57727	TMPS3_HUMAN	transmembrane protease, serine 3	101	LDL-receptor class A.				cellular sodium ion homeostasis|proteolysis	endoplasmic reticulum membrane|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity|sodium channel regulator activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(4)|skin(1)	13						CTCGTCCTCCCCGTCTTTGCA	0.537000													7	22					0	0	1	0	0
ADH1B	125	broad.mit.edu	37	4	100232746	100232746	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:100232746G>A	ENST00000305046.8	-	7	963	c.896C>T	c.(895-897)tCc>tTc	p.S299F	ADH1B_ENST00000394887.3_Missense_Mutation_p.S259F			P00325	ADH1B_HUMAN	alcohol dehydrogenase 1B (class I), beta polypeptide	299					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	33				OV - Ovarian serous cystadenocarcinoma(123;1.02e-07)	Fomepizole(DB01213)|NADH(DB00157)	GAGGTTCTGGGAAGCAGGAGG	0.483000													37	62					0	0	1	0	0
PPP1R16A	84988	broad.mit.edu	37	8	145724154	145724154	+	Splice_Site	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:145724154C>T	ENST00000292539.4	+	3	1178	c.259_splice	c.e3-1	p.V87_splice	PPP1R16A_ENST00000435887.1_Splice_Site_p.V87_splice|CTD-2517M22.14_ENST00000532766.1_RNA|CTD-2517M14.5_ENST00000569326.1_RNA			Q96I34	PP16A_HUMAN	protein phosphatase 1, regulatory subunit 16A	87						plasma membrane	protein binding			NS(1)|endometrium(1)|kidney(2)|lung(3)|prostate(1)	8	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TTTTTGCAGTCCGCCAGTTCC	0.647000													4	37					0	0	1	0	0
OR5B2	390190	broad.mit.edu	37	11	58190386	58190386	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:58190386C>T	ENST00000302581.2	-	1	400	c.349G>A	c.(349-351)Gcc>Acc	p.A117T		NM_001005566.2	NP_001005566.1	Q96R09	OR5B2_HUMAN	olfactory receptor, family 5, subfamily B, member 2	117					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|large_intestine(2)|lung(19)|ovary(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CGGTCATAGGCCATTGAGGCC	0.517000													13	19					0	0	1	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36096937	36096937	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:36096937G>A	ENST00000258840.6	-	34	5229	c.4839C>T	c.(4837-4839)acC>acT	p.T1613T	RALGAPA1_ENST00000307138.6_Silent_p.T1566T|RALGAPA1_ENST00000389698.3_Silent_p.T1566T|RALGAPA1_ENST00000382366.3_Silent_p.T1579T			Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1 (catalytic)	1566	Minimal domain that binds to TCF3/E12 (By similarity).				activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(7)|large_intestine(14)|lung(21)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						aggacactaaggttgtattat	0.388000													15	21					0	0	1	0	0
CCDC129	223075	broad.mit.edu	37	7	31617569	31617569	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:31617569G>A	ENST00000319386.3	+	8	1684	c.691G>A	c.(691-693)Gag>Aag	p.E231K	CCDC129_ENST00000451887.2_Missense_Mutation_p.E257K|CCDC129_ENST00000409210.1_Missense_Mutation_p.E139K|CCDC129_ENST00000407970.3_Missense_Mutation_p.E231K			Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	231										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						CAGAGCTGAAGAGAAAGCTGG	0.493000													7	12					0	0	1	0	0
ITGAL	3683	broad.mit.edu	37	16	30507826	30507826	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr16:30507826C>T	ENST00000356798.6	+	15	1951	c.1771C>T	c.(1771-1773)Ctt>Ttt	p.L591F	ITGAL_ENST00000433423.2_Intron|ITGAL_ENST00000358164.5_Missense_Mutation_p.L508F	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	591					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	GGTGAAGGACCTTGAAGGGGA	0.557000													17	33					0	0	1	0	0
DYNAP	284254	broad.mit.edu	37	18	52262290	52262290	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr18:52262290C>T	ENST00000321600.1	+	2	302	c.256C>T	c.(256-258)Ctt>Ttt	p.L86F	DYNAP_ENST00000585973.1_Intron	NM_173629.1	NP_775900.1			dynactin associated protein																		CCCAGGAATCCTTGCACATTC	0.458000													32	43					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167805771	167805771	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:167805771C>T	ENST00000367848.1	-	23	3306	c.2809G>A	c.(2809-2811)Gaa>Aaa	p.E937K	ADCY10_ENST00000367851.4_Missense_Mutation_p.E1029K|ADCY10_ENST00000545172.1_Missense_Mutation_p.E876K|ADCY10_ENST00000485964.1_Intron			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	1029					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						TCTCTTATTTCTTCAGGACTG	0.363000													29	23					0	0	1	0	0
ILDR1	286676	broad.mit.edu	37	3	121712276	121712276	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:121712276C>T	ENST00000273691.3	-	6	1293	c.1188G>A	c.(1186-1188)agG>agA	p.R396R	ILDR1_ENST00000462014.1_Silent_p.R408R|ILDR1_ENST00000393631.1_Silent_p.R351R|ILDR1_ENST00000344209.5_Silent_p.R440R|ILDR1_ENST00000460554.1_5'UTR	NM_175924.3	NP_787120.1	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor 1	440						cytosol|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(114;0.156)		GACAGCGGCTCCTGAAAGGAG	0.667000													6	12					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82784402	82784402	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:82784402G>A	ENST00000423517.2	-	2	1892	c.1555C>T	c.(1555-1557)Ccc>Tcc	p.P519S	PCLO_ENST00000333891.8_Missense_Mutation_p.P519S	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	465	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TGAGGTGAGGGCTTTGCTGGG	0.597000													110	115					0	0	1	0	0
GABRB1	2560	broad.mit.edu	37	4	47408856	47408856	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:47408856C>T	ENST00000295454.3	+	8	1285	c.993C>T	c.(991-993)ttC>ttT	p.F331F	GABRB1_ENST00000538619.1_Silent_p.F261F	NM_000812.3	NP_000803.2	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 1	331					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ATTACATCTTCTTTGGGAAAG	0.398000													17	35					0	0	1	0	0
AXDND1	126859	broad.mit.edu	37	1	179437748	179437748	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:179437748C>T	ENST00000367618.3	+	17	2356	c.1969C>T	c.(1969-1971)Cca>Tca	p.P657S	AXDND1_ENST00000457238.2_3'UTR|AXDND1_ENST00000461179.2_3'UTR	NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	657										NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						TGGTATTGTTCCACAGCACAT	0.333000													9	25					0	0	1	0	0
RP11-44F14.1	0	broad.mit.edu	37	16	53403416	53403416	+	RNA	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr16:53403416C>T	ENST00000565421.1	-	0	1201																											CAGAATTTTTCTTTACATTTA	0.323000													3	0					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11561983	11561983	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:11561983C>T	ENST00000294484.6	+	2	1072	c.934C>T	c.(934-936)Cgg>Tgg	p.R312W	PTCHD2_ENST00000389575.3_Missense_Mutation_p.R312W	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	312					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CCCAGGCTTCCGGGAGTTCTG	0.617000													16	5					0	0	1	0	0
SCRN1	9805	broad.mit.edu	37	7	29976244	29976244	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:29976244C>T	ENST00000426154.1	-	6	1009	c.833G>A	c.(832-834)gGa>gAa	p.G278E	SCRN1_ENST00000242059.5_Missense_Mutation_p.G278E|SCRN1_ENST00000409497.1_Missense_Mutation_p.G278E|SCRN1_ENST00000416113.2_Missense_Mutation_p.G104E	NM_001145513.1	NP_001138985.1	Q12765	SCRN1_HUMAN	secernin 1	278					exocytosis|proteolysis	cytoplasm|nuclear membrane	dipeptidase activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(12)|ovary(2)|prostate(2)|skin(2)	25						GACAGACACTCCACTGGCTGT	0.522000													26	44					0	0	1	0	0
IRF2BPL	64207	broad.mit.edu	37	14	77492270	77492270	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:77492270G>A	ENST00000238647.3	-	1	2764	c.1866C>T	c.(1864-1866)tcC>tcT	p.S622S		NM_024496.3	NP_078772.1	Q9H1B7	I2BPL_HUMAN	interferon regulatory factor 2 binding protein-like	622	Pro-rich.					nucleus				endometrium(2)|kidney(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	11						CGGCCATAGGGGACGGACCGT	0.701000													6	7					0	0	1	0	0
AQP1	358	broad.mit.edu	37	7	30963079	30963079	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:30963079G>A	ENST00000311813.4	+	4	700	c.645G>A	c.(643-645)ggG>ggA	p.G215G	AQP1_ENST00000434909.2_Silent_p.G275G|AQP1_ENST00000482461.1_3'UTR|AQP1_ENST00000509504.1_Silent_p.G392G|AQP1_ENST00000441328.2_Silent_p.G132G|AQP1_ENST00000409611.1_Silent_p.G164G|AQP1_ENST00000409899.1_Silent_p.G100G	NM_198098.2	NP_932766.1			aquaporin 1									p.G132G(1)|p.G215G(1)		kidney(1)|large_intestine(2)|lung(9)	12		Melanoma(862;0.16)				TCTGGGTGGGGCCATTCATCG	0.612000													15	12					0	0	1	0	0
OR4K1	79544	broad.mit.edu	37	14	20404502	20404502	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr14:20404502G>A	ENST00000285600.4	+	1	736	c.677G>A	c.(676-678)cGa>cAa	p.R226Q		NM_001004063.2	NP_001004063.2	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K, member 1	226					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(24)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		ATCGGTGTCCGATGCAGGTCC	0.413000													14	76					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52554068	52554068	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:52554068C>T	ENST00000321725.6	+	51	5420	c.5344C>T	c.(5344-5346)Ctg>Ttg	p.L1782L		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	1782	FAS1 6.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CCAGGCCTGGCTGTACCATGA	0.622000													13	21					0	0	1	0	0
NFE2	4778	broad.mit.edu	37	12	54686796	54686796	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:54686796C>T	ENST00000540264.2	-	2	993	c.484G>A	c.(484-486)Ggg>Agg	p.G162R	NFE2_ENST00000435572.2_Missense_Mutation_p.G162R|NFE2_ENST00000312156.4_Missense_Mutation_p.G162R|RP11-968A15.8_ENST00000553061.1_RNA|NFE2_ENST00000553070.1_Missense_Mutation_p.G162R			Q16621	NFE2_HUMAN	nuclear factor, erythroid 2	162	Transactivation domain.				blood circulation|blood coagulation|multicellular organismal development|nucleosome disassembly|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	actin cytoskeleton|cytoplasm|PML body	protein dimerization activity|protein N-terminus binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|WW domain binding			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(7)|upper_aerodigestive_tract(2)	16						GCCTCTGTCCCCTCCAGCTCA	0.557000													32	69					0	0	1	0	0
RFC3	5983	broad.mit.edu	37	13	34410403	34410403	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr13:34410403G>A	ENST00000380071.3	+	9	1172	c.1042G>A	c.(1042-1044)Gag>Aag	p.E348K	RFC3_ENST00000434425.1_Intron	NM_002915.3	NP_002906.1	P40938	RFC3_HUMAN	replication factor C (activator 1) 3, 38kDa	348					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|response to organophosphorus|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			lung(2)|skin(1)	3		Hepatocellular(188;0.0191)|Lung SC(185;0.0548)		all cancers(112;5.09e-06)|Epithelial(112;6.52e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00107)|OV - Ovarian serous cystadenocarcinoma(117;0.0285)|GBM - Glioblastoma multiforme(144;0.123)		GAAGTTCATGGAGGATGGATT	0.398000													96	12					0	0	1	0	0
CCDC62	84660	broad.mit.edu	37	12	123286354	123286354	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:123286354C>A	ENST00000253079.6	+	9	2005	c.1661C>A	c.(1660-1662)aCc>aAc	p.T554N	CCDC62_ENST00000537566.1_Missense_Mutation_p.T315N|CCDC62_ENST00000392440.2_Missense_Mutation_p.T315N|CCDC62_ENST00000392441.4_Missense_Mutation_p.T554N	NM_201435.4	NP_958843.2	Q6P9F0	CCD62_HUMAN	coiled-coil domain containing 62	554						cytoplasm|nucleus				breast(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(1)	20	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.51e-06)|Epithelial(86;2.65e-05)|BRCA - Breast invasive adenocarcinoma(302;0.206)		TCTGGGTGCACCTGTTCAGAA	0.488000													86	140					6.00224e-42	6.17312e-42	1	1	0
POLR2I	5438	broad.mit.edu	37	19	36605722	36605722	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:36605722C>T	ENST00000221859.4	-	1	526	c.37G>A	c.(37-39)Ggt>Agt	p.G13S		NM_006233.4	NP_006224.1	P36954	RPB9_HUMAN	polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa	13					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|zinc ion binding			kidney(1)|large_intestine(1)|ovary(1)	3	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			AAGCGAATACCCACGAAGCCC	0.682000													65	69					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141643791	141643791	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:141643791C>T	ENST00000389484.3	-	24	4851	c.3880G>A	c.(3880-3882)Gat>Aat	p.D1294N		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1294					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AAGTGAAAATCAAGTGCTATT	0.338000										TSP Lung(27;0.18)			13	15					0	0	1	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102300666	102300666	+	RNA	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:102300666G>A	ENST00000561463.1	+	0	8712																											ACTCGCATCGGAACCTGCAGA	0.597000													7	17					0	0	1	0	0
POLR2I	5438	broad.mit.edu	37	19	36605721	36605721	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:36605721C>T	ENST00000221859.4	-	1	527	c.38G>A	c.(37-39)gGt>gAt	p.G13D		NM_006233.4	NP_006224.1	P36954	RPB9_HUMAN	polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa	13					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|zinc ion binding			kidney(1)|large_intestine(1)|ovary(1)	3	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GAAGCGAATACCCACGAAGCC	0.682000													65	69					0	0	1	0	0
RAET1E	135250	broad.mit.edu	37	6	150211183	150211183	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:150211183G>A	ENST00000532335.1	-	3	530	c.184C>T	c.(184-186)Ctt>Ttt	p.L62F	RAET1E_ENST00000357183.4_Missense_Mutation_p.L62F|RAET1E_ENST00000367363.3_Intron|RP11-244K5.1_ENST00000605899.1_RNA|RAET1E_ENST00000529948.1_Missense_Mutation_p.L62F|RP11-244K5.8_ENST00000606915.1_RNA	NM_001243328.1	NP_001230257.1	Q8TD07	N2DL4_HUMAN	retinoic acid early transcript 1E	62	MHC class I alpha-1 like.				antigen processing and presentation|immune response|regulation of immune response	integral to membrane|MHC class I protein complex	protein binding			cervix(1)|kidney(2)|large_intestine(3)|lung(3)|skin(1)	10		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.58e-12)		TTGTACTGAAGGAAAAGATTT	0.478000													10	11					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78440578	78440578	+	Silent	SNP	G	G	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:78440578G>T	ENST00000278550.7	-	22	3711	c.3249C>A	c.(3247-3249)acC>acA	p.T1083T		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		TGAAGGGGATGGTCGGGTGGG	0.567000													10	19					0.0581538	0.0582546	1	1	0
TCTE1	202500	broad.mit.edu	37	6	44253779	44253779	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr6:44253779G>A	ENST00000371505.4	-	3	890	c.768C>T	c.(766-768)ttC>ttT	p.F256F	TMEM151B_ENST00000438774.2_Intron|TCTE1_ENST00000371504.1_Silent_p.F103F|TCTE1_ENST00000371503.3_Silent_p.F103F	NM_182539.3	NP_872345.2	Q5JU00	TCTE1_HUMAN	t-complex-associated-testis-expressed 1	256										breast(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GATTCCACTCGAAATTCATGC	0.582000													25	49					0	0	1	0	0
FILIP1L	11259	broad.mit.edu	37	3	99569317	99569317	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:99569317C>T	ENST00000331335.5	-	5	1673	c.1203G>A	c.(1201-1203)aaG>aaA	p.K401K	CMSS1_ENST00000496116.1_Intron|CMSS1_ENST00000421999.2_Intron|FILIP1L_ENST00000476723.1_Intron|FILIP1L_ENST00000383694.2_Silent_p.K161K|FILIP1L_ENST00000471562.1_Silent_p.K161K|FILIP1L_ENST00000487087.1_Intron|FILIP1L_ENST00000354552.3_Silent_p.K401K	NM_001042459.1	NP_001035924.1	Q4L180	FIL1L_HUMAN	filamin A interacting protein 1-like	401						cytoplasm|membrane|myosin complex|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	35						TTTCAAGCCTCTTATTGAGAT	0.408000													57	82					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82474650	82474650	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:82474650G>A	ENST00000423517.2	-	13	14320	c.13983C>T	c.(13981-13983)tcC>tcT	p.S4661S	PCLO_ENST00000333891.8_Silent_p.S4661S|PCLO_ENST00000426442.2_5'UTR	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4549	C2 1.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GGCTGGGAACGGAACTGGATC	0.512000													19	17					0	0	1	0	0
NFATC2	4773	broad.mit.edu	37	20	50158908	50158908	+	Splice_Site	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:50158908C>T	ENST00000371564.3	-	1	350		c.e1+1		NFATC2_ENST00000396009.3_Splice_Site|NFATC2_ENST00000414705.1_Intron	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2						B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					CCTCCACCGACCTTCGTTCGG	0.667000													15	9					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61542407	61542407	+	Silent	SNP	A	A	G			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr20:61542407A>G	ENST00000266070.4	-	3	883	c.558T>C	c.(556-558)agT>agC	p.S186S	DIDO1_ENST00000370371.4_Silent_p.S186S|DIDO1_ENST00000395335.2_Silent_p.S186S|DIDO1_ENST00000395340.1_Silent_p.S186S|DIDO1_ENST00000370366.1_Silent_p.S186S|DIDO1_ENST00000370368.1_Silent_p.S186S|DIDO1_ENST00000395343.1_Silent_p.S186S|DIDO1_ENST00000354665.4_Silent_p.S186S|DIDO1_ENST00000266071.5_Silent_p.S186S	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	186					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					TCCGCAGGCGACTCTGGATCC	0.637000													19	20					0	0	1	0	0
MGAT4C	25834	broad.mit.edu	37	12	86383274	86383274	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:86383274C>T	ENST00000604798.1	-	6	1255	c.51G>A	c.(49-51)atG>atA	p.M17I	MGAT4C_ENST00000552435.2_Missense_Mutation_p.M17I|MGAT4C_ENST00000549405.2_Missense_Mutation_p.M17I|MGAT4C_ENST00000332156.1_Missense_Mutation_p.M17I|MGAT4C_ENST00000393205.2_Missense_Mutation_p.M46I|MGAT4C_ENST00000552808.2_Missense_Mutation_p.M17I|MGAT4C_ENST00000548651.1_Missense_Mutation_p.M17I			Q9UBM8	MGT4C_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)	17					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						TCAGGCATCTCATTTTATCAA	0.323000													8	17					0	0	1	0	0
ZDHHC17	23390	broad.mit.edu	37	12	77220694	77220694	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:77220694C>T	ENST00000426126.2	+	9	1553	c.904C>T	c.(904-906)Cgg>Tgg	p.R302W	ZDHHC17_ENST00000334822.5_Missense_Mutation_p.R302W	NM_015336.2	NP_056151.2	Q8IUH5	ZDH17_HUMAN	zinc finger, DHHC-type containing 17	302					lipoprotein transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi-associated vesicle membrane|integral to membrane	magnesium ion transmembrane transporter activity|protein binding|protein-cysteine S-palmitoleyltransferase activity|signal transducer activity|zinc ion binding			breast(2)|endometrium(2)|large_intestine(3)|liver(2)|lung(14)	23						ACAGGAATTTCGGCAGAAAGT	0.358000													17	23					0	0	1	0	0
CD276	80381	broad.mit.edu	37	15	73996237	73996237	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:73996237C>T	ENST00000318443.5	+	5	1273	c.971C>T	c.(970-972)tCc>tTc	p.S324F	CD276_ENST00000561213.1_Missense_Mutation_p.S324F|CD276_ENST00000537340.2_Missense_Mutation_p.S178F|CD276_ENST00000318424.5_Intron|CD276_ENST00000564751.1_Intron	NM_001024736.1	NP_001019907.1	Q5ZPR3	CD276_HUMAN	CD276 molecule	324	Ig-like V-type 2.				cell proliferation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of T cell proliferation|regulation of immune response|T cell activation	external side of plasma membrane|integral to membrane	receptor binding			endometrium(3)|lung(5)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	13						GGCAATGCATCCCTGAGGCTG	0.662000													8	19					0	0	1	0	0
PRKCE	5581	broad.mit.edu	37	2	46234779	46234779	+	Silent	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr2:46234779G>A	ENST00000306156.3	+	9	1569	c.1242G>A	c.(1240-1242)ttG>ttA	p.L414L	PRKCE_ENST00000394874.1_Silent_p.L137L	NM_005400.2	NP_005391.1	Q02156	KPCE_HUMAN	protein kinase C, epsilon	414	Protein kinase.				activation of phospholipase C activity|induction of apoptosis|intracellular signal transduction|nerve growth factor receptor signaling pathway|platelet activation	cytosol|endoplasmic reticulum|plasma membrane	ATP binding|enzyme activator activity|metal ion binding|signal transducer activity		MBOAT2/PRKCE(2)	breast(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(13)|ovary(3)|upper_aerodigestive_tract(2)	34		all_hematologic(82;0.155)|Acute lymphoblastic leukemia(82;0.209)	LUSC - Lung squamous cell carcinoma(58;0.171)			TCAAGGTGTTGGGCAAAGGCA	0.542000													10	16					0	0	1	0	0
DZIP1L	199221	broad.mit.edu	37	3	137786462	137786462	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:137786462G>A	ENST00000327532.2	-	14	2275	c.1913C>T	c.(1912-1914)tCc>tTc	p.S638F		NM_173543.2	NP_775814.2	Q8IYY4	DZI1L_HUMAN	DAZ interacting zinc finger protein 1-like	638						intracellular	zinc ion binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(2)|prostate(1)|skin(1)	35						CACCATCCTGGAAGGAACTTT	0.622000													14	26					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50760635	50760635	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:50760635C>T	ENST00000440075.2	+	18	2171	c.2124C>T	c.(2122-2124)ttC>ttT	p.F708F	MYH14_ENST00000376970.2_Silent_p.F700F|MYH14_ENST00000425460.1_Silent_p.F675F|MYH14_ENST00000596571.1_Silent_p.F667F|MYH14_ENST00000601313.1_Silent_p.F708F|MYH14_ENST00000262269.8_Silent_p.F708F|MYH14_ENST00000598205.1_Silent_p.F675F			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	667	Myosin head-like.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		GGGGTATGTTCCGGACAGTGG	0.637000													4	6					0	0	1	0	0
ACTRT1	139741	broad.mit.edu	37	X	127185140	127185140	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:127185140G>A	ENST00000371124.3	-	1	1242	c.1046C>T	c.(1045-1047)tCt>tTt	p.S349F		NM_138289.3	NP_612146.1	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	349						cytoplasm|cytoskeleton				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	34						ACTGCTCATAGAGGTCATGAT	0.473000													42	14					0	0	1	0	0
FAM76A	199870	broad.mit.edu	37	1	28086074	28086074	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:28086074C>T	ENST00000373954.6	+	8	875	c.773C>T	c.(772-774)tCg>tTg	p.S258L	FAM76A_ENST00000373949.1_Missense_Mutation_p.S229L|FAM76A_ENST00000530324.1_Missense_Mutation_p.S258L|FAM76A_ENST00000419687.2_Missense_Mutation_p.S178L|FAM76A_ENST00000234549.7_Missense_Mutation_p.S263L|FAM76A_ENST00000010299.6_Missense_Mutation_p.S292L	NM_001143912.1|NM_152660.2	NP_001137384.1|NP_689873.1	Q8TAV0	FA76A_HUMAN	family with sequence similarity 76, member A	258										endometrium(4)|kidney(2)|large_intestine(1)|lung(2)	9		Colorectal(325;0.000147)|all_lung(284;0.00181)|Lung NSC(340;0.00278)|Renal(390;0.00357)|Breast(348;0.0115)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0429)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-24)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;1.75e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00253)|KIRC - Kidney renal clear cell carcinoma(1967;0.00292)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0649)		TACCAGGAATCGCAGATGAGA	0.383000													12	19					0	0	1	0	0
FKBP9	11328	broad.mit.edu	37	7	33016019	33016019	+	Missense_Mutation	SNP	C	C	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr7:33016019C>A	ENST00000242209.4	+	4	780	c.611C>A	c.(610-612)cCt>cAt	p.P204H	FKBP9_ENST00000489038.1_Intron|FKBP9_ENST00000538443.1_Missense_Mutation_p.P66H|AVL9_ENST00000404479.1_Intron|FKBP9_ENST00000538336.1_Missense_Mutation_p.P257H	NM_007270.3	NP_009201.2	O95302	FKBP9_HUMAN	FK506 binding protein 9, 63 kDa	204	PPIase FKBP-type 2.				protein folding	endoplasmic reticulum|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(13)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	39			GBM - Glioblastoma multiforme(11;0.0156)			TGGCTGATTCCTGGAATGGAT	0.468000													28	51					2.61193e-14	2.66495e-14	1	1	0
SLC35G5	83650	broad.mit.edu	37	8	11189031	11189031	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:11189031C>T	ENST00000382435.4	+	1	635	c.416C>T	c.(415-417)aCc>aTc	p.T139I		NM_054028.1	NP_473369.1	Q96KT7	AMCL2_HUMAN	solute carrier family 35, member G5	139	DUF6 1.					integral to membrane											GGTTCTTCCACCGTATGCTCC	0.572000													45	72					0	0	1	0	0
FAM83G	644815	broad.mit.edu	37	17	18882028	18882028	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:18882028C>T	ENST00000388995.6	-	5	1174	c.951G>A	c.(949-951)atG>atA	p.M317I	FAM83G_ENST00000585154.2_Missense_Mutation_p.M317I|SLC5A10_ENST00000417251.2_Intron|SLC5A10_ENST00000317977.6_Intron|SLC5A10_ENST00000395647.2_Intron|SLC5A10_ENST00000395642.1_Intron|FAM83G_ENST00000345041.4_Missense_Mutation_p.M317I|SLC5A10_ENST00000395645.3_Intron|SLC5A10_ENST00000395643.2_Intron			A6ND36	FA83G_HUMAN	family with sequence similarity 83, member G	317										central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(7)|ovary(2)|prostate(3)|stomach(1)	22						GTTCCTTCTCCATAGGGATGC	0.602000													23	54					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3239744	3239744	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chrX:3239744C>T	ENST00000217939.6	-	5	4136	c.3982G>A	c.(3982-3984)Gat>Aat	p.D1328N		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1328						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GCAACATCATCCTTAATTTCT	0.373000													27	32					0	0	1	0	0
HTR4	3360	broad.mit.edu	37	5	147863877	147863877	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr5:147863877G>A	ENST00000360693.3	-	7	1280	c.1142C>T	c.(1141-1143)cCa>cTa	p.P381L	HTR4_ENST00000314512.6_Intron|HTR4_ENST00000521530.1_Intron|HTR4_ENST00000377888.3_Intron|HTR4_ENST00000521735.1_Intron|HTR4_ENST00000517929.1_Intron|HTR4_ENST00000354217.2_Intron|HTR4_ENST00000520514.1_Intron|HTR4_ENST00000362016.2_Intron	NM_001040173.2	NP_001035263.1	Q13639	5HT4R_HUMAN	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	359					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	GCCTGAGAATGGACCCGCTCT	0.393000													9	11					0	0	1	0	0
CD33	945	broad.mit.edu	37	19	51742803	51742803	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:51742803C>T	ENST00000262262.4	+	7	976	c.955C>T	c.(955-957)Ccc>Tcc	p.P319S	CD33_ENST00000600557.1_3'UTR|CD33_ENST00000421133.2_Missense_Mutation_p.P192S	NM_001772.3	NP_001763.3	P20138	CD33_HUMAN	CD33 molecule	319					cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(15)|skin(1)|stomach(1)	24		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	GTTACATGGCCCCACTGAAAC	0.522000													15	17					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	97454834	97454834	+	Silent	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr3:97454834C>T	ENST00000389672.5	+	16	3038	c.3000C>T	c.(2998-3000)caC>caT	p.H1000H		NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	905	SAM.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						CATCTCTACACCAGCTGATGC	0.453000													8	16					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10363573	10363573	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:10363573G>A	ENST00000255381.2	-	13	1323	c.1213C>T	c.(1213-1215)Ccc>Tcc	p.P405S	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	405	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						TTGACTCTGGGATAGCAGAGA	0.453000													15	29					0	0	1	0	0
OR2T6	254879	broad.mit.edu	37	1	248551795	248551795	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:248551795G>A	ENST00000355728.2	+	1	886	c.886G>A	c.(886-888)Gat>Aat	p.D296N		NM_001005471.1	NP_001005471.1	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T, member 6	296					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.D296N(1)		endometrium(3)|large_intestine(5)|lung(38)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GAGGAACAGGGATGTGATGGG	0.453000													6	11					0	0	1	0	0
KIAA1377	57562	broad.mit.edu	37	11	101832821	101832821	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:101832821C>T	ENST00000263468.8	+	6	1325	c.1055C>T	c.(1054-1056)cCt>cTt	p.P352L	KIAA1377_ENST00000537689.1_Missense_Mutation_p.P153L	NM_020802.2	NP_065853.2	Q9P2H0	K1377_HUMAN	KIAA1377	352							protein binding			breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(18)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	53	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		AATCCATCTCCTTTGAATGGA	0.333000													15	22					0	0	1	0	0
SEC24D	9871	broad.mit.edu	37	4	119745862	119745862	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr4:119745862C>T	ENST00000379735.5	-	3	432	c.161G>A	c.(160-162)aGg>aAg	p.R54K	SEC24D_ENST00000280551.6_Missense_Mutation_p.R54K|SEC24D_ENST00000419654.2_5'UTR	NM_014822.2	NP_055637.2	O94855	SC24D_HUMAN	SEC24 family member D	54	Pro-rich.				COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(13)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	37						CAACATTCCCCTAGTGGCGGT	0.547000													26	51					0	0	1	0	0
VPS13A	23230	broad.mit.edu	37	9	79966256	79966256	+	Missense_Mutation	SNP	C	C	T			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr9:79966256C>T	ENST00000360280.3	+	53	7573	c.7313C>T	c.(7312-7314)tCc>tTc	p.S2438F	VPS13A_ENST00000376634.4_Missense_Mutation_p.S2438F|VPS13A_ENST00000376636.3_Missense_Mutation_p.S2399F|VPS13A_ENST00000357409.5_Missense_Mutation_p.S2438F	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)	2438					Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						ATAGAAGATTCCCTCCCTCCT	0.393000													38	20					0	0	1	0	0
MAP4K2	5871	broad.mit.edu	37	11	64567094	64567094	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:64567094G>A	ENST00000294066.2	-	13	1068	c.977C>T	c.(976-978)aCc>aTc	p.T326I	MAP4K2_ENST00000377350.3_Missense_Mutation_p.T326I	NM_004579.3	NP_004570.2	Q12851	M4K2_HUMAN	mitogen-activated protein kinase kinase kinase kinase 2	326					activation of JUN kinase activity|immune response|positive regulation of JNK cascade|vesicle targeting	basolateral plasma membrane|Golgi membrane|soluble fraction	ATP binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(1)|lung(3)|ovary(1)|pancreas(1)|urinary_tract(2)	8						CTCCGAGGGGGTCCTCTCGGC	0.572000													5	10					0	0	1	0	0
ZBTB16	7704	broad.mit.edu	37	11	113934732	113934732	+	Missense_Mutation	SNP	G	G	A			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr11:113934732G>A	ENST00000335953.4	+	2	1090	c.710G>A	c.(709-711)gGg>gAg	p.G237E	ZBTB16_ENST00000392996.2_Missense_Mutation_p.G237E	NM_006006.4	NP_005997.2	Q05516	ZBT16_HUMAN	zinc finger and BTB domain containing 16	237					apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding	p.G237V(1)		central_nervous_system(1)|large_intestine(2)|skin(1)|upper_aerodigestive_tract(2)	6		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		CGGCACCCTGGGGTGGCTGAG	0.642000													8	8					0	0	1	0	0
HNRNPR	10236	broad.mit.edu	37	1	23637421	23637432	+	In_Frame_Del	DEL	ACCATAGTAATC	ACCATAGTAATC	-			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:23637421_23637432delACCATAGTAATC	ENST00000478691.1	-	10	1394_1405	c.1123_1134delGATTACTATGGT	c.(1123-1134)del	p.DYYG375del	HNRNPR_ENST00000426846.2_In_Frame_Del_p.DYYG313del|HNRNPR_ENST00000427764.2_In_Frame_Del_p.DYYG435del|HNRNPR_ENST00000302271.6_In_Frame_Del_p.DYYG473del|HNRNPR_ENST00000476660.1_5'UTR|HNRNPR_ENST00000606561.1_In_Frame_Del_p.DYYG334del|HNRNPR_ENST00000374612.1_In_Frame_Del_p.DYYG473del|HNRNPR_ENST00000374616.3_In_Frame_Del_p.DYYG476del	NM_001102397.1|NM_001102399.1	NP_001095867.1|NP_001095869.1	O43390	HNRPR_HUMAN	heterogeneous nuclear ribonucleoprotein R	473	RRM 3.					catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding	p.G476C(2)		endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)		GATAATCATAACCATAGTAATCATCATAGTAA	0.505													43	79	---	---	---	---					
PGBD2	267002	broad.mit.edu	37	1	249211273	249211274	+	Frame_Shift_Del	DEL	TA	TA	-			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr1:249211273_249211274delTA	ENST00000539153.1	+	4	736_737	c.481_482delTA	c.(481-483)tfs	p.Y161fs	PGBD2_ENST00000355360.4_Intron|PGBD2_ENST00000462488.1_Intron|PGBD2_ENST00000329291.5_Frame_Shift_Del_p.Y164fs			Q6P3X8	PGBD2_HUMAN	piggyBac transposable element derived 2	164										NS(1)|endometrium(3)|lung(6)|ovary(1)|skin(3)	14	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.012)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			AACCAATCGTTATGCTTGGCAG	0.376													44	53	---	---	---	---					
MFSD3	113655	broad.mit.edu	37	8	145735775	145735777	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr8:145735775_145735777delCTC	ENST00000301327.4	+	2	975_977	c.715_717delCTC	c.(715-717)del	p.L241del		NM_138431.1	NP_612440.1	Q96ES6	MFSD3_HUMAN	major facilitator superfamily domain containing 3	241	Leu-rich.				transmembrane transport	integral to membrane				central_nervous_system(2)|endometrium(1)|kidney(1)|lung(4)	8	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			GTTTCCTCTTCTCCTGCTGGACC	0.640													17	94	---	---	---	---					
CD63	967	broad.mit.edu	37	12	56120745	56120746	+	Frame_Shift_Ins	INS	-	-	AA			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:56120745_56120746insAA	ENST00000549117.1	-	4	694_695	c.258_259insTT	c.(256-261)ttccatfs	p.H87fs	CD63_ENST00000420846.3_Frame_Shift_Ins_p.H87fs|CD63_ENST00000257857.4_Frame_Shift_Ins_p.H87fs|CD63_ENST00000550776.1_Frame_Shift_Ins_p.H5fs|CD63_ENST00000548898.1_5'UTR|CD63_ENST00000548160.1_5'UTR|CD63_ENST00000552692.1_Frame_Shift_Ins_p.H87fs|CD63_ENST00000552754.1_Frame_Shift_Ins_p.H64fs|CD63_ENST00000546939.1_Frame_Shift_Ins_p.H5fs|CD63_ENST00000552067.1_5'UTR	NM_001257389.1	NP_001244318.1	P08962	CD63_HUMAN	CD63 molecule	87					platelet activation|platelet degranulation	integral to plasma membrane|late endosome membrane|lysosomal membrane|platelet dense granule membrane				kidney(1)|large_intestine(3)|lung(2)|ovary(1)	7						AGAAAGATGGCAAACTGCAGGA	0.515													40	79	---	---	---	---					
SFSWAP	6433	broad.mit.edu	37	12	132281734	132281736	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr12:132281734_132281736delAGA	ENST00000261674.4	+	16	2687_2689	c.2546_2548delAGA	c.(2545-2550)gag>g	p.EK849del	SFSWAP_ENST00000541286.1_In_Frame_Del_p.EK901del|SFSWAP_ENST00000539506.1_3'UTR	NM_004592.3	NP_004583.2	Q12872	SFSWA_HUMAN	splicing factor, suppressor of white-apricot homolog (Drosophila)	849	Arg/Ser-rich (RS domain).				mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(8)|ovary(1)|skin(2)	25						AGTCCCCACGAGAAGAAGAAGAA	0.606													7	172	---	---	---	---					
CSPG4	1464	broad.mit.edu	37	15	75980196	75980197	+	Frame_Shift_Ins	INS	-	-	GCCAC			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr15:75980196_75980197insGCCAC	ENST00000308508.5	-	3	3301_3302	c.3209_3210insGTGGC	c.(3208-3210)ggtfs	p.G1070fs		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	1070	Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL5A1 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						GCTCATCTACGGCCACGATACT	0.619													11	76	---	---	---	---					
GP1BA	2811	broad.mit.edu	37	17	4837358	4837359	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr17:4837358_4837359delCT	ENST00000329125.5	+	2	1534_1535	c.1459_1460delCT	c.(1459-1461)cfs	p.L488fs		NM_000173.5	NP_000164.5	E7ES66	E7ES66_HUMAN	glycoprotein Ib (platelet), alpha polypeptide	488										central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(5)|stomach(1)|urinary_tract(1)	20						ACCCGTATCACTCTTAGAATCC	0.500													22	25	---	---	---	---					
CAMSAP3	57662	broad.mit.edu	37	19	7677563	7677563	+	Frame_Shift_Del	DEL	G	G	-			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:7677563delG	ENST00000446248.2	+	13	2366	c.2265delG	c.(2263-2265)ctfs	p.L755fs	CAMSAP3_ENST00000160298.4_Frame_Shift_Del_p.L728fs	NM_001080429.2	NP_001073898.1	Q9P1Y5	CAMP3_HUMAN	calmodulin regulated spectrin-associated protein family, member 3	728	Pro-rich.				epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			cervix(1)|endometrium(7)|kidney(3)|lung(6)|urinary_tract(2)	19						AGCGGCTCCTGGCCCCGCCCG	0.721													2	4	---	---	---	---					
NUMBL	9253	broad.mit.edu	37	19	41173866	41173868	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-D9-A4Z3-01A-11D-A25O-08	TCGA-D9-A4Z3-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F1AFC678-EFCB-45AD-85C3-25D40EEA7117	3BACFA26-6DB7-45CC-84FE-8ECFC3B9A3A4	g.chr19:41173866_41173868delTGC	ENST00000252891.4	-	10	1502_1504	c.1335_1337delGCA	c.(1333-1338)caa>ca	p.QQ445del	NUMBL_ENST00000540131.1_In_Frame_Del_p.QQ404del|NUMBL_ENST00000598779.1_In_Frame_Del_p.QQ404del	NM_004756.3	NP_004747.1	Q9Y6R0	NUMBL_HUMAN	numb homolog (Drosophila)-like	445	Poly-Gln.				cytokine-mediated signaling pathway|lateral ventricle development|neuroblast division in subventricular zone|protein metabolic process	cytoplasm	protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)	16			Lung(22;0.000393)|LUSC - Lung squamous cell carcinoma(20;0.00105)			TGAGgctgcttgctgctgttgct	0.670													2	4	---	---	---	---					
