Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZFHX4	79776	broad.mit.edu	37	8	77616502	77616502	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr8:77616502C>T	ENST00000521891.2	+	2	627	c.179C>T	c.(178-180)gCc>gTc	p.A60V	ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000455469.2_Missense_Mutation_p.A60V|ZFHX4_ENST00000518282.1_Missense_Mutation_p.A60V|ZFHX4_ENST00000050961.6_Missense_Mutation_p.A60V	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	60						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AAAAGTGAAGCCTTGCTGGGT	0.498000										HNSCC(33;0.089)			53	55					0	0	1	0	0
SLC10A4	201780	broad.mit.edu	37	4	48490573	48490573	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr4:48490573G>A	ENST00000273861.4	+	3	1150	c.931G>A	c.(931-933)Ggc>Agc	p.G311S		NM_152679.3	NP_689892.1	Q96EP9	NTCP4_HUMAN	solute carrier family 10, member 4	311						integral to membrane	bile acid:sodium symporter activity			central_nervous_system(1)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	6						GCCTTTGGCAGGCTACGCTTC	0.468000													112	119					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25330355	25330355	+	RNA	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr15:25330355G>A	ENST00000546682.1	+	0	339				SNHG14_ENST00000549804.2_RNA	NR_003361.1																						GGCATAGAAGGAAGGCCAGTG	0.517000													5	6					0	0	1	0	0
PITPNM2	57605	broad.mit.edu	37	12	123479984	123479984	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:123479984G>A	ENST00000280562.5	-	13	2211	c.2006C>T	c.(2005-2007)tCc>tTc	p.S669F	PITPNM2_ENST00000542749.1_Missense_Mutation_p.S669F|PITPNM2_ENST00000392428.1_Missense_Mutation_p.S390F|PITPNM2_ENST00000320201.4_Missense_Mutation_p.S669F			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	669					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		CTCGTAGGTGGATGAGTCGCT	0.652000													36	64					0	0	1	0	0
CHTF18	63922	broad.mit.edu	37	16	846742	846742	+	Missense_Mutation	SNP	C	C	G			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr16:846742C>G	ENST00000317063.6	+	21	3109	c.3109C>G	c.(3109-3111)Cct>Gct	p.P1037A	CHTF18_ENST00000262315.9_Missense_Mutation_p.P828A|CHTF18_ENST00000455171.2_Missense_Mutation_p.P856A			Q8WVB6	CTF18_HUMAN	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	828					cell cycle|DNA replication	nucleus	ATP binding|DNA binding|nucleoside-triphosphatase activity			endometrium(1)|kidney(3)|liver(2)|lung(4)|prostate(1)	11		Hepatocellular(780;0.00335)				CTGCCGCTTCCCTGAGCTGCC	0.687000													25	20					0	0	1	0	0
OR8D2	283160	broad.mit.edu	37	11	124189313	124189313	+	Missense_Mutation	SNP	T	T	G			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr11:124189313T>G	ENST00000357438.2	-	1	871	c.781A>C	c.(781-783)Aag>Cag	p.K261Q		NM_001002918.1	NP_001002918.1	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D, member 2	261					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		GAAGGGGGCTTGAAATACATG	0.438000													101	108					0	0	1	0	0
MIR4485	100616263	broad.mit.edu	37	MT	3091	3091	+	RNA	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chrM:3091G>A	ENST00000387347.2	+	0	1421					NR_039705.1																						GGAGTAATCCAGGTCGGTTTC	0.453000													17	92					0	0	1	0	0
ZNF182	7569	broad.mit.edu	37	X	47861996	47861996	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chrX:47861996G>A	ENST00000376943.3	-	3	298	c.13C>T	c.(13-15)Cag>Tag	p.Q5*	ZNF182_ENST00000305127.6_5'UTR|ZNF182_ENST00000396965.1_5'UTR	NM_001007088.1	NP_001007089.1	P17025	ZN182_HUMAN	zinc finger protein 182	24					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|prostate(1)	22						ATACTTACCTGGGGTTTGGCC	0.433000													18	5					0	0	1	0	0
RPE65	6121	broad.mit.edu	37	1	68906581	68906581	+	Missense_Mutation	SNP	A	A	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:68906581A>T	ENST00000262340.5	-	6	651	c.598T>A	c.(598-600)Ttt>Att	p.F200I		NM_000329.2	NP_000320.1	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein 65kDa	200					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			central_nervous_system(1)|kidney(3)|large_intestine(12)|lung(15)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	35						GCAATTGAAAAATTTTTTCCA	0.388000													27	26					0	0	1	0	0
JAK1	3716	broad.mit.edu	37	1	65309857	65309857	+	Nonsense_Mutation	SNP	C	C	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:65309857C>A	ENST00000342505.4	-	17	2541	c.2293G>T	c.(2293-2295)Gag>Tag	p.E765*	JAK1_ENST00000465376.1_5'UTR	NM_002227.2	NP_002218.2	P23458	JAK1_HUMAN	Janus kinase 1	765	Protein kinase 1.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(48)|kidney(3)|large_intestine(8)|liver(2)|lung(19)|ovary(1)|prostate(12)|skin(1)|soft_tissue(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	120				BRCA - Breast invasive adenocarcinoma(111;0.0485)		TTGGAGTCCTCAACACACTCA	0.488000			Mis		ALL								82	107					1.17954e-47	1.21348e-47	1	1	0
PRB2	653247	broad.mit.edu	37	12	11546699	11546699	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:11546699C>T	ENST00000389362.4	-	3	348	c.313G>A	c.(313-315)Gga>Aga	p.G105R	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2											NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			GACTTGTCTCCTTGTGGGGGT	0.607000													298	607					0	0	1	0	0
ZNF678	339500	broad.mit.edu	37	1	227842965	227842965	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:227842965C>T	ENST00000343776.4	+	4	1359	c.1014C>T	c.(1012-1014)agC>agT	p.S338S	ZNF678_ENST00000498759.1_Intron|ZNF678_ENST00000397097.3_Silent_p.S393S			F5GXA7	F5GXA7_HUMAN	zinc finger protein 678	393					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(7)|pancreas(1)|prostate(1)	24		Prostate(94;0.0885)				ACCTAAGTAGCCATAAGAGAA	0.373000													33	50					0	0	1	0	0
NPAS3	64067	broad.mit.edu	37	14	34269520	34269520	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr14:34269520C>T	ENST00000346562.2	+	11	1985	c.1911C>T	c.(1909-1911)ccC>ccT	p.P637P	NPAS3_ENST00000551492.1_Silent_p.P674P|NPAS3_ENST00000548645.1_Silent_p.P639P|NPAS3_ENST00000356141.4_Silent_p.P669P|NPAS3_ENST00000357798.5_Silent_p.P656P	NM_001164749.1|NM_001165893.1|NM_022123.2|NM_173159.2	NP_001158221.1|NP_001159365.1|NP_071406.1|NP_775182.1	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3	669					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	40	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		ACTACCCGCCCAACCGGGAGA	0.622000													49	9					0	0	1	0	0
ZNF626	199777	broad.mit.edu	37	19	20807307	20807307	+	Missense_Mutation	SNP	C	C	T	rs111831210		TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:20807307C>T	ENST00000601440.1	-	4	1522	c.1376G>A	c.(1375-1377)gGc>gAc	p.G459D	CTC-513N18.7_ENST00000595094.1_lincRNA	NM_001076675.2	NP_001070143.1	Q68DY1	ZN626_HUMAN	zinc finger protein 626	459					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|lung(3)|skin(1)	6						AAAAGCTTTGCCACATTCTTC	0.393000													4	22					0	0	1	0	0
PACRG	135138	broad.mit.edu	37	6	163235288	163235288	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr6:163235288C>T	ENST00000337019.3	+	3	490	c.266C>T	c.(265-267)tCg>tTg	p.S89L	PACRG_ENST00000542669.1_3'UTR|PACRG_ENST00000366889.2_Missense_Mutation_p.S89L|PACRG_ENST00000366888.2_Missense_Mutation_p.S89L	NM_152410.2	NP_689623.2	Q96M98	PACRG_HUMAN	PARK2 co-regulated	89										endometrium(2)|large_intestine(6)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Breast(66;2.41e-05)|Ovarian(120;0.0245)|Prostate(117;0.0273)|all_neural(5;0.0416)|Glioma(2;0.203)		OV - Ovarian serous cystadenocarcinoma(33;4.31e-19)|GBM - Glioblastoma multiforme(2;7.42e-11)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)|KIRC - Kidney renal clear cell carcinoma(3;0.205)|Kidney(3;0.242)		GAGCATGATTCGAAAGGAAAC	0.517000													93	19					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170029612	170029612	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:170029612C>T	ENST00000263816.3	-	57	11422	c.11137G>A	c.(11137-11139)Ggc>Agc	p.G3713S		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3713	LDL-receptor class A 30.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CTACCACAGCCTTGCTCATCA	0.498000													46	49					0	0	1	0	0
ATR	545	broad.mit.edu	37	3	142172059	142172059	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr3:142172059G>A	ENST00000350721.4	-	46	7793	c.7672C>T	c.(7672-7674)Cta>Tta	p.L2558L	ATR_ENST00000383101.3_Silent_p.L2494L	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	2558	PI3K/PI4K.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						GGATCATGTAGAAAAGTCTTT	0.353000								Other conserved DNA damage response genes					49	7					0	0	1	0	0
C2orf76	130355	broad.mit.edu	37	2	120078775	120078775	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:120078775G>A	ENST00000409466.2	-	4	660	c.139C>T	c.(139-141)Cct>Tct	p.P47S	C2orf76_ENST00000409877.1_Missense_Mutation_p.P47S|C2orf76_ENST00000334816.7_Missense_Mutation_p.P47S|C2orf76_ENST00000409523.1_Missense_Mutation_p.P47S			Q3KRA6	CB076_HUMAN	chromosome 2 open reading frame 76	47										large_intestine(1)|lung(3)|pancreas(1)	5						GTCCTTAAAGGGATATCTACA	0.274000													36	33					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13419020	13419020	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:13419020G>A	ENST00000360228.5	-	14	1826	c.1827C>T	c.(1825-1827)tcC>tcT	p.S609S	CACNA1A_ENST00000573710.2_Silent_p.S610S	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	610					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TGGACTTCATGGAGTTGAGGA	0.577000													24	26					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31305348	31305348	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:31305348C>T	ENST00000265071.2	+	7	1332	c.1067C>T	c.(1066-1068)cCa>cTa	p.P356L	CDH6_ENST00000514738.1_Missense_Mutation_p.P301L	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	356	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						TATGTTGAGCCACGATTTCTC	0.468000													43	64					0	0	1	0	0
CHST4	10164	broad.mit.edu	37	16	71571304	71571304	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr16:71571304C>T	ENST00000338482.5	+	3	1067	c.724C>T	c.(724-726)Ccc>Tcc	p.P242S	CHST4_ENST00000539698.3_Missense_Mutation_p.P242S|RP11-510M2.9_ENST00000572693.1_RNA|CHST4_ENST00000572450.1_Missense_Mutation_p.P242S|ZNF19_ENST00000568446.1_Intron			Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4	242					cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			cervix(1)|kidney(3)|large_intestine(9)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	21						GGAGGACCAACCCTACTATGT	0.542000											OREG0023923	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	38					0	0	1	0	0
NOL6	65083	broad.mit.edu	37	9	33467424	33467424	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr9:33467424G>A	ENST00000379471.2	-	13	1780	c.1693C>T	c.(1693-1695)Ctt>Ttt	p.L565F	NOL6_ENST00000455041.2_Missense_Mutation_p.L513F|NOL6_ENST00000464829.1_Intron			Q9H6R4	NOL6_HUMAN	nucleolar protein 6 (RNA-associated)	565					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			endometrium(4)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|skin(2)	27			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		CCCAGCTCAAGGACGCTGGTC	0.607000											OREG0019137	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	5					0	0	1	0	0
DPPA5	340168	broad.mit.edu	37	6	74063752	74063752	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr6:74063752G>A	ENST00000370370.3	-	2	185	c.116C>T	c.(115-117)cCg>cTg	p.P39L		NM_001025290.2	NP_001020461.1	A6NC42	DPPA5_HUMAN	developmental pluripotency associated 5	39	KH; atypical.				multicellular organismal development	cytoplasm	RNA binding			NS(1)|endometrium(1)|lung(5)	7						AGATCCGTCCGGGCCTGTTGG	0.612000													69	17					0	0	1	0	0
GFPT2	9945	broad.mit.edu	37	5	179755296	179755296	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:179755296C>T	ENST00000253778.8	-	7	746	c.577G>A	c.(577-579)Gga>Aga	p.G193R		NM_005110.2	NP_005101.1	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	193	Glutamine amidotransferase type-2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	ACGGCTTCTCCTGGGTAGTGG	0.527000											OREG0017113	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	52	76					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	71029629	71029629	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:71029629G>A	ENST00000334414.6	-	2	317	c.273C>T	c.(271-273)ccC>ccT	p.P91P	PTPRB_ENST00000538174.2_5'UTR|PTPRB_ENST00000551525.1_Silent_p.P90P|PTPRB_ENST00000550358.1_Silent_p.P91P	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	0	Fibronectin type-III 1.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AGGTCCATCGGGGTGCCTGGG	0.547000													26	15					0	0	1	0	0
SCP2	6342	broad.mit.edu	37	1	53453763	53453763	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:53453763C>T	ENST00000371514.3	+	11	1204	c.1036C>T	c.(1036-1038)Cct>Tct	p.P346S	SCP2_ENST00000528311.1_Missense_Mutation_p.P265S|SCP2_ENST00000371513.5_Missense_Mutation_p.P302S|SCP2_ENST00000407246.2_Missense_Mutation_p.P322S|SCP2_ENST00000371509.4_Missense_Mutation_p.P302S	NM_002979.4	NP_002970.2	P22307	NLTP_HUMAN	sterol carrier protein 2	346					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|lipid transport	mitochondrion|nucleus|peroxisomal matrix	propanoyl-CoA C-acyltransferase activity|propionyl-CoA C2-trimethyltridecanoyltransferase activity|protein binding|sterol binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	15						GGTCATAAATCCTAGTGGTGG	0.358000													31	37					0	0	1	0	0
MIR526B	574468	broad.mit.edu	37	19	54197669	54197669	+	RNA	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:54197669G>A	ENST00000384848.1	+	0	23					NR_030190.1																						CCTCTTGAGGGAAGCACTTTC	0.388000													57	54					0	0	1	0	0
TRPC4AP	26133	broad.mit.edu	37	20	33594310	33594310	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr20:33594310G>A	ENST00000252015.2	-	15	1844	c.1755C>T	c.(1753-1755)ctC>ctT	p.L585L	TRPC4AP_ENST00000539834.1_Silent_p.L187L|TRPC4AP_ENST00000451813.1_Silent_p.L577L|TRPC4AP_ENST00000432634.2_Silent_p.L546L			Q8TEL6	TP4AP_HUMAN	transient receptor potential cation channel, subfamily C, member 4 associated protein	585					protein ubiquitination|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	protein binding			breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|skin(1)|stomach(1)|urinary_tract(1)	32			BRCA - Breast invasive adenocarcinoma(18;0.00936)			GCTCCCCCAGGAGGTCAAAGT	0.473000													46	54					0	0	1	0	0
THAP4	51078	broad.mit.edu	37	2	242572482	242572482	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:242572482C>T	ENST00000407315.1	-	2	1521	c.1090G>A	c.(1090-1092)Gag>Aag	p.E364K		NM_015963.5	NP_057047.4	Q8WY91	THAP4_HUMAN	THAP domain containing 4	364							DNA binding|metal ion binding			kidney(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)	9		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;2.3e-33)|all cancers(36;8.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.68e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0844)		TCCACCTGCTCCCGCAGGCAG	0.627000													18	45					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24434973	24434973	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:24434973G>A	ENST00000330966.7	-	2	316	c.154C>T	c.(154-156)Cgc>Tgc	p.R52C	MYOM3_ENST00000374434.3_Missense_Mutation_p.R52C|MYOM3_ENST00000329601.7_Missense_Mutation_p.R52C			Q5VTT5	MYOM3_HUMAN	myomesin 3	52										NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		CACCTGCTGCGGAAGGTCCGC	0.697000													3	13					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7699819	7699819	+	Missense_Mutation	SNP	A	A	G			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr17:7699819A>G	ENST00000572933.1	+	50	9172	c.7712A>G	c.(7711-7713)aAt>aGt	p.N2571S	DNAH2_ENST00000389173.2_Missense_Mutation_p.N2571S			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2571	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				ACCATGATCAATCAGAAGCTT	0.547000													44	61					0	0	1	0	0
HAT1	8520	broad.mit.edu	37	2	172822971	172822971	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:172822971C>T	ENST00000264108.4	+	7	689	c.653C>T	c.(652-654)aCc>aTc	p.T218I	SLC25A12_ENST00000472748.1_Intron|HAT1_ENST00000392584.1_Missense_Mutation_p.T133I	NM_003642.3	NP_003633.1	O14929	HAT1_HUMAN	histone acetyltransferase 1	218					chromatin silencing at telomere|DNA packaging	cytoplasm|nuclear matrix|nucleoplasm	histone acetyltransferase activity|protein binding			breast(1)|kidney(1)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|prostate(1)	19			OV - Ovarian serous cystadenocarcinoma(117;0.216)			CTCTTTGCGACCGTAGGCTAC	0.443000													56	56					0	0	1	0	0
ST8SIA4	7903	broad.mit.edu	37	5	100231378	100231378	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:100231378G>A	ENST00000231461.5	-	2	535	c.225C>T	c.(223-225)tcC>tcT	p.S75S	ST8SIA4_ENST00000451528.2_Silent_p.S75S	NM_005668.4	NP_005659.1	Q92187	SIA8D_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	75					axon guidance|N-glycan processing	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)	25		all_cancers(142;1.5e-07)|all_epithelial(76;1.43e-10)|Prostate(80;0.000644)|Lung NSC(167;0.0059)|all_lung(232;0.00914)|Ovarian(225;0.024)|Colorectal(57;0.09)|Breast(839;0.203)		COAD - Colon adenocarcinoma(37;0.00402)		GGACCAAAGAGGAATTGATTT	0.383000													41	55					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70486792	70486792	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:70486792G>A	ENST00000310961.5	+	17	1844	c.1426G>A	c.(1426-1428)Gaa>Aaa	p.E476K	LRRC7_ENST00000415775.2_Silent_p.T2T|RP11-181B18.1_ENST00000425754.1_RNA|LRRC7_ENST00000035383.5_Missense_Mutation_p.E471K|RP11-181B18.1_ENST00000414132.1_RNA			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	471						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						AGAAGATGACGAAAATGCTGG	0.388000													30	52					0	0	1	0	0
RASSF9	9182	broad.mit.edu	37	12	86198613	86198613	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:86198613C>T	ENST00000361228.3	-	2	1543	c.1175G>A	c.(1174-1176)gGg>gAg	p.G392E		NM_005447.3	NP_005438.2	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family (N-terminal) member 9	392					endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						AGGAATCTCCCCATTGCTACT	0.443000													83	92					0	0	1	0	0
TM7SF2	7108	broad.mit.edu	37	11	64880977	64880977	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr11:64880977G>A	ENST00000279263.7	+	5	676	c.514G>A	c.(514-516)Gac>Aac	p.D172N	TM7SF2_ENST00000540748.1_Missense_Mutation_p.D56N|TM7SF2_ENST00000345348.5_Missense_Mutation_p.D172N|TM7SF2_ENST00000531029.1_Intron	NM_003273.2	NP_003264.2	O76062	ERG24_HUMAN	transmembrane 7 superfamily member 2	172					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane	delta14-sterol reductase activity			lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TCCGATTTACGACTTTTTTCT	0.532000											OREG0021072	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	160	204					0	0	1	0	0
AAK1	22848	broad.mit.edu	37	2	69757182	69757182	+	Missense_Mutation	SNP	G	G	C			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:69757182G>C	ENST00000409085.4	-	8	1205	c.829C>G	c.(829-831)Cct>Gct	p.P277A	AAK1_ENST00000406297.3_Missense_Mutation_p.P277A|AAK1_ENST00000409068.1_Missense_Mutation_p.P277A	NM_014911.3	NP_055726.3	Q2M2I8	AAK1_HUMAN	AP2 associated kinase 1	277	Protein kinase.					coated pit|mitochondrion|plasma membrane	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)	17						GAATTATCAGGAATTGTGAAG	0.313000													9	17					0	0	1	0	0
JPH4	84502	broad.mit.edu	37	14	24040638	24040638	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr14:24040638G>A	ENST00000397118.3	-	6	2204	c.1302C>T	c.(1300-1302)tcC>tcT	p.S434S	JPH4_ENST00000356300.4_Silent_p.S434S|JPH4_ENST00000544177.1_Silent_p.S99S	NM_032452.2	NP_115828.2	Q96JJ6	JPH4_HUMAN	junctophilin 4	434					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane				endometrium(1)|large_intestine(2)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		GCTCCGTGTCGGAACCTTCTG	0.617000													30	9					0	0	1	0	0
ANKFN1	162282	broad.mit.edu	37	17	54534321	54534321	+	Splice_Site	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr17:54534321G>A	ENST00000566473.2	+	11	1316	c.1316_splice	c.e11+1	p.R439_splice	ANKFN1_ENST00000318698.2_Splice_Site_p.R439_splice			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	439										NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						ACCTTAAAACGGTGGGTTCTA	0.383000													20	20					0	0	1	0	0
FBLN2	2199	broad.mit.edu	37	3	13612761	13612761	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr3:13612761G>A	ENST00000404922.3	+	2	1025	c.906G>A	c.(904-906)agG>agA	p.R302R	FBLN2_ENST00000295760.7_Silent_p.R302R|FBLN2_ENST00000535798.1_Silent_p.R328R|FBLN2_ENST00000492059.1_Silent_p.R302R	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	302	N.|Subdomain NB (Cys-free).					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			GTGGCCACAGGGGGCTGGATG	0.622000													9	0					0	0	1	0	0
SYT2	127833	broad.mit.edu	37	1	202566023	202566023	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:202566023G>A	ENST00000367267.1	-	9	1314	c.1122C>T	c.(1120-1122)atC>atT	p.I374I	SYT2_ENST00000367268.4_Silent_p.I374I	NM_001136504.1	NP_001129976.1	Q8N9I0	SYT2_HUMAN	synaptotagmin II	374	C2 2.|Phospholipid binding (By similarity).				neurotransmitter secretion	cell junction|chromaffin granule membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	protein binding|transporter activity			NS(1)|breast(4)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(9)|ovary(2)|skin(2)|urinary_tract(1)	29			BRCA - Breast invasive adenocarcinoma(75;0.169)		Botulinum Toxin Type B(DB00042)	TGCCCACGAAGATCTTGCCTA	0.607000													47	59					0	0	1	0	0
ZDHHC8P1	150244	broad.mit.edu	37	22	23742697	23742697	+	RNA	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr22:23742697C>T	ENST00000255890.4	-	0	512																											CAGGGAAGTCCAGGCTCGGCT	0.612000													13	19					0	0	1	0	0
ZNF205	7755	broad.mit.edu	37	16	3169293	3169293	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr16:3169293C>T	ENST00000382192.3	+	7	837	c.632C>T	c.(631-633)tCc>tTc	p.S211F	RP11-473M20.14_ENST00000575139.1_RNA|ZNF205_ENST00000219091.4_Missense_Mutation_p.S211F|RP11-473M20.14_ENST00000576490.1_RNA	NM_001278158.1|NM_003456.2	NP_001265087.1|NP_003447.2	O95201	ZN205_HUMAN	zinc finger protein 205	211					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	20						CAGACCTCATCCGTGGCAGCC	0.642000													49	50					0	0	1	0	0
COL27A1	85301	broad.mit.edu	37	9	116930345	116930345	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr9:116930345G>A	ENST00000356083.3	+	3	901	c.510G>A	c.(508-510)ctG>ctA	p.L170L		NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1	170	Laminin G-like.|TSP N-terminal.				cell adhesion		extracellular matrix structural constituent			central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						CAGTCACTCTGGTGACTGCCT	0.682000													55	5					0	0	1	0	0
SLC2A14	144195	broad.mit.edu	37	12	7970586	7970586	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:7970586C>T	ENST00000543909.1	-	15	1944	c.1185G>A	c.(1183-1185)ttG>ttA	p.L395L	SLC2A14_ENST00000431042.2_Silent_p.L372L|SLC2A14_ENST00000542546.1_Silent_p.L286L|SLC2A14_ENST00000396589.2_Silent_p.L395L|SLC2A14_ENST00000539924.1_Silent_p.L410L|SLC2A14_ENST00000535295.1_Silent_p.L286L|SLC2A14_ENST00000542505.1_Silent_p.L36L|SLC2A14_ENST00000340749.5_Silent_p.L372L			Q8TDB8	GTR14_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 14	395					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	38				Kidney(36;0.0883)		CCACAAAGACCAAGATAGCCC	0.488000													11	35					0	0	1	0	0
ICA1L	130026	broad.mit.edu	37	2	203682235	203682235	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:203682235G>A	ENST00000392237.2	-	7	747	c.590C>T	c.(589-591)tCt>tTt	p.S197F	ICA1L_ENST00000358299.2_Missense_Mutation_p.S197F	NM_138468.4	NP_612477.3	Q8NDH6	ICA1L_HUMAN	islet cell autoantigen 1,69kDa-like	197	AH.									breast(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CTTGTCAAAAGAAGCTTTGCT	0.338000													34	54					0	0	1	0	0
MCC	4163	broad.mit.edu	37	5	112384984	112384984	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:112384984C>T	ENST00000302475.4	-	14	2454	c.1891G>A	c.(1891-1893)Gag>Aag	p.E631K	MCC_ENST00000408903.3_Missense_Mutation_p.E821K|MCC_ENST00000514701.3_5'UTR|MCC_ENST00000515367.2_Missense_Mutation_p.E568K	NM_002387.2	NP_002378.1	P23508	CRCM_HUMAN	mutated in colorectal cancers	631					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		GCCTTCAACTCGGCCATCTCC	0.617000													15	12					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16967624	16967624	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr10:16967624G>A	ENST00000377833.4	-	42	6486	c.6421C>T	c.(6421-6423)Cca>Tca	p.P2141S		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	2141	CUB 15.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TCTCCATTTGGAATCTGGAAA	0.448000													25	5					0	0	1	0	0
KCTD8	386617	broad.mit.edu	37	4	44177004	44177004	+	Missense_Mutation	SNP	T	T	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr4:44177004T>A	ENST00000360029.3	-	2	1508	c.1225A>T	c.(1225-1227)Aac>Tac	p.N409Y		NM_198353.2	NP_938167.1	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerization domain containing 8	409						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(3)|upper_aerodigestive_tract(4)	41						AGTTCACTGTTTCTGCGTTTG	0.453000										HNSCC(17;0.042)			123	187					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11511565	11511565	+	Missense_Mutation	SNP	A	A	C			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr17:11511565A>C	ENST00000262442.3	+	2	605	c.537A>C	c.(535-537)caA>caC	p.Q179H	DNAH9_ENST00000579406.1_3'UTR|DNAH9_ENST00000454412.2_Missense_Mutation_p.Q179H|DNAH9_ENST00000579828.1_Missense_Mutation_p.Q179H	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	179	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TACTTGAGCAAGTGAAGGGAA	0.502000													17	245					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150327191	150327191	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr7:150327191G>A	ENST00000328902.5	-	2	256	c.40C>T	c.(40-42)Ccc>Tcc	p.P14S	GIMAP6_ENST00000493969.1_Missense_Mutation_p.P14S	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	14							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TCTTCTGGGGGATTCTCCTGG	0.423000													85	144					0	0	1	0	0
GABRA3	2556	broad.mit.edu	37	X	151366229	151366229	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chrX:151366229G>A	ENST00000370314.4	-	8	1045	c.807C>T	c.(805-807)ttC>ttT	p.F269F	GABRA3_ENST00000535043.1_Silent_p.F269F|GABRA3_ENST00000370311.1_Silent_p.F269F	NM_000808.3	NP_000799.1	P34903	GBRA3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 3	269					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(6)	37	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GCTTGAGATGGAAGTGGGTTG	0.413000													41	10					0	0	1	0	0
YIPF2	78992	broad.mit.edu	37	19	11038602	11038602	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:11038602G>A	ENST00000586748.1	-	3	237	c.65C>T	c.(64-66)aCc>aTc	p.T22I	YIPF2_ENST00000590329.1_Missense_Mutation_p.T22I|YIPF2_ENST00000253031.2_Missense_Mutation_p.T22I			Q9BWQ6	YIPF2_HUMAN	Yip1 domain family, member 2	22						integral to membrane|transport vesicle				cervix(1)|endometrium(1)|lung(3)|ovary(2)	7						TGCATCTGGGGTGTCAGCCAG	0.597000													54	72					0	0	1	0	0
HSPA4L	22824	broad.mit.edu	37	4	128732660	128732660	+	Missense_Mutation	SNP	C	C	T	rs141362649		TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr4:128732660C>T	ENST00000296464.3	+	12	1858	c.1447C>T	c.(1447-1449)Cgt>Tgt	p.R483C	HSPA4L_ENST00000508776.1_Missense_Mutation_p.R483C|HSPA4L_ENST00000505726.1_Missense_Mutation_p.R457C|HSPA4L_ENST00000439123.2_Missense_Mutation_p.R514C	NM_014278.2	NP_055093.2	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	483					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	31						GGTTAAAGTTCGTGTTAACAT	0.408000													25	53					0	0	1	0	0
THEG	51298	broad.mit.edu	37	19	371295	371295	+	Silent	SNP	C	C	G			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:371295C>G	ENST00000342640.4	-	6	705	c.663G>C	c.(661-663)cgG>cgC	p.R221R	THEG_ENST00000346878.2_Silent_p.R197R	NM_016585.4	NP_057669.1	Q9P2T0	THEG_HUMAN	theg spermatid protein	221					cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)|soft_tissue(1)	29		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAGGGAGGACCGAGGAATGG	0.612000													88	157					0	0	1	0	0
GCG	2641	broad.mit.edu	37	2	163000624	163000624	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:163000624G>A	ENST00000418842.2	-	5	703	c.449C>T	c.(448-450)tCt>tTt	p.S150F	GCG_ENST00000375497.3_Missense_Mutation_p.S150F	NM_002054.4	NP_002045.1	P01275	GLUC_HUMAN	glucagon	150					cell proliferation|cellular response to glucagon stimulus|energy reserve metabolic process|feeding behavior|regulation of insulin secretion	plasma membrane|soluble fraction	hormone activity	p.S150Y(2)		breast(1)|central_nervous_system(1)|large_intestine(3)|lung(9)	14					Exenatide(DB01276)|Phentolamine(DB00692)	ATCAGAGAAAGAACCATCAGC	0.393000													39	68					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13769652	13769652	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:13769652C>T	ENST00000265104.4	-	57	9782	c.9678G>A	c.(9676-9678)gcG>gcA	p.A3226A	DNAH5_ENST00000504001.3_5'UTR	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3226	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CCTTTTCTTTCGCTTCCAGTT	0.433000									Kartagener syndrome				104	120					0	0	1	0	0
ESPNP	284729	broad.mit.edu	37	1	17023182	17023182	+	RNA	SNP	C	C	G	rs614461	by1000genomes	TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:17023182C>G	ENST00000492551.1	-	0	1681					NR_026567.1																						CGGCAGCGGCCAATCGGGCTG	0.692000													12	38					0	0	1	0	0
RASA2	5922	broad.mit.edu	37	3	141326576	141326576	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr3:141326576G>A	ENST00000286364.3	+	20	2025	c.1990G>A	c.(1990-1992)Gaa>Aaa	p.E664K	RASA2_ENST00000452898.1_Missense_Mutation_p.E665K|RASA2_ENST00000509118.1_3'UTR			Q15283	RASA2_HUMAN	RAS p21 protein activator 2	664	PH.				intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	34						GGAAAAACTGGAAGAGAGCTC	0.269000													15	4					0	0	1	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70714155	70714155	+	RNA	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr14:70714155G>A	ENST00000530196.1	-	0	363					NR_003951.1																						ACCCTCATATGAACAACATGT	0.512000													63	107					0	0	1	0	0
ENPP6	133121	broad.mit.edu	37	4	185074772	185074772	+	Missense_Mutation	SNP	C	C	G			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr4:185074772C>G	ENST00000296741.2	-	2	497	c.356G>C	c.(355-357)gGa>gCa	p.G119A		NM_153343.3	NP_699174.1	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 6	119					lipid catabolic process	extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(2)	15		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		AGGTTCTGATCCATTCCACCA	0.493000													35	47					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77616503	77616503	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr8:77616503C>T	ENST00000521891.2	+	2	628	c.180C>T	c.(178-180)gcC>gcT	p.A60A	ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000455469.2_Silent_p.A60A|ZFHX4_ENST00000518282.1_Silent_p.A60A|ZFHX4_ENST00000050961.6_Silent_p.A60A	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	60						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AAAGTGAAGCCTTGCTGGGTT	0.493000										HNSCC(33;0.089)			55	57					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82545020	82545020	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr7:82545020G>A	ENST00000423517.2	-	7	12619	c.12282C>T	c.(12280-12282)ttC>ttT	p.F4094F	PCLO_ENST00000437081.1_Silent_p.F814F|PCLO_ENST00000333891.8_Silent_p.F4094F	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4025					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						AAGGTGCTAGGAAATCTGTCA	0.453000													15	16					0	0	1	0	0
LRFN1	57622	broad.mit.edu	37	19	39805230	39805230	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:39805230G>A	ENST00000248668.4	-	1	746	c.747C>T	c.(745-747)ttC>ttT	p.F249F		NM_020862.1	NP_065913.1	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III domain containing 1	249						cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GGTTGCCGCCGAAGCTGACGG	0.692000													7	16					0	0	1	0	0
SEMA4C	54910	broad.mit.edu	37	2	97532091	97532091	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:97532091C>T	ENST00000305476.5	-	3	319	c.187G>A	c.(187-189)Ggg>Agg	p.G63R		NM_017789.4	NP_060259.4	Q9C0C4	SEM4C_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C	63	Dominant negative effect on myogenic differentiation (By similarity).|Sema.				muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			NS(1)|kidney(1)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	17						TACAGAAGCCCAGTGGGCTCC	0.652000													82	82					0	0	1	0	0
B4GALNT4	338707	broad.mit.edu	37	11	380152	380152	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr11:380152G>A	ENST00000329962.6	+	17	2665	c.2665G>A	c.(2665-2667)Ggg>Agg	p.G889R		NM_178537.4	NP_848632.2	Q76KP1	B4GN4_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 4	889						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			endometrium(2)|kidney(4)|large_intestine(1)|liver(2)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	24		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GAGACGAACCGGGAACTTCGA	0.687000													14	25					0	0	1	0	0
KCNJ8	3764	broad.mit.edu	37	12	21919425	21919425	+	Silent	SNP	G	G	A	rs139304559	byFrequency	TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:21919425G>A	ENST00000240662.2	-	3	852	c.507C>T	c.(505-507)atC>atT	p.I169I	RP11-59N23.1_ENST00000542489.1_RNA	NM_004982.3	NP_004973.1	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 8	169						voltage-gated potassium channel complex				cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28					Levosimendan(DB00922)	TGACTGCATTGATGATCAAAC	0.458000													31	40					0	0	1	0	0
PCDHGB7	56099	broad.mit.edu	37	5	140798899	140798899	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:140798899C>T	ENST00000398594.2	+	1	1473	c.1473C>T	c.(1471-1473)ctC>ctT	p.L491L	PCDHGB1_ENST00000523390.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_018927.3	NP_061750.1														central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(13)|lung(15)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(3)	56			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTACTCTCTCATTGCCAGCG	0.637000													49	69					0	0	1	0	0
RABGAP1L	9910	broad.mit.edu	37	1	174219700	174219700	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:174219700C>T	ENST00000251507.4	+	6	979	c.805C>T	c.(805-807)Ccc>Tcc	p.P269S	RABGAP1L_ENST00000367689.3_5'UTR|RABGAP1L_ENST00000357444.6_Missense_Mutation_p.P232S	NM_014857.4	NP_055672.3	Q5R372	RBG1L_HUMAN	RAB GTPase activating protein 1-like	269	PID.				regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			NS(1)|breast(2)|endometrium(4)|kidney(5)|large_intestine(7)|lung(21)|ovary(2)|prostate(1)|skin(2)	45						TATTCCTACCCCCGACAGTGA	0.383000													33	58					0	0	1	0	0
NINJ2	4815	broad.mit.edu	37	12	675055	675055	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:675055G>A	ENST00000433832.2	-	2	415	c.215C>T	c.(214-216)cCc>cTc	p.P72L	NINJ2_ENST00000542920.1_Intron|NINJ2_ENST00000537416.1_5'UTR|NINJ2_ENST00000305108.4_Intron|NINJ2_ENST00000397265.3_Intron			Q9NZG7	NINJ2_HUMAN	ninjurin 2	0					nervous system development|neuron cell-cell adhesion|tissue regeneration	integral to plasma membrane				large_intestine(3)|lung(1)|ovary(2)	6	all_cancers(10;0.0101)|all_epithelial(11;0.0174)|Ovarian(42;0.0512)|all_lung(10;0.103)|Lung NSC(10;0.185)		OV - Ovarian serous cystadenocarcinoma(31;3.26e-05)|BRCA - Breast invasive adenocarcinoma(9;0.0508)			GGACACGTGGGGCCTTTCTGC	0.632000													11	18					0	0	1	0	0
HERC2P2	400322	broad.mit.edu	37	15	23300079	23300079	+	RNA	SNP	T	T	G	rs417713	by1000genomes	TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr15:23300079T>G	ENST00000560464.1	-	0	4208																											GTGCTGCACGTTGACAGGCGT	0.607000													4	34					0	0	1	0	0
CYP4A22	284541	broad.mit.edu	37	1	47606502	47606502	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:47606502C>T	ENST00000371891.3	+	2	277	c.246C>T	c.(244-246)ttC>ttT	p.F82F	CYP4A22-AS1_ENST00000444042.2_lincRNA|CYP4A22_ENST00000371890.3_Silent_p.F82F|CYP4A22_ENST00000294337.3_Silent_p.F82F|CYP4A22_ENST00000485117.1_3'UTR	NM_001010969.2	NP_001010969.2	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 22	82						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TGAAGACATTCCCAAGTGCCT	0.478000													69	84					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6219720	6219720	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:6219720G>A	ENST00000261405.5	-	5	606	c.352C>T	c.(352-354)Ctg>Ttg	p.L118L	VWF_ENST00000572068.1_Silent_p.L155L	NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	118	VWFD 1.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	TCTAGATACAGCCCTTTGGAG	0.532000													43	82					0	0	1	0	0
TTC37	9652	broad.mit.edu	37	5	94830395	94830395	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:94830395G>A	ENST00000358746.2	-	36	4091	c.3793C>T	c.(3793-3795)Ctt>Ttt	p.L1265F		NM_014639.3	NP_055454.1	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	1265							binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(13)|liver(1)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	47						CCTGGAGAAAGGAGAGCTGCC	0.353000													95	131					0	0	1	0	0
TRBV5-4	28611	broad.mit.edu	37	7	142168459	142168459	+	RNA	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr7:142168459G>A	ENST00000454561.2	-	0	464																											TATCATTAGGGAACTGGAGAC	0.537000													72	87					0	0	1	0	0
ATP6V0D2	245972	broad.mit.edu	37	8	87151851	87151851	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr8:87151851C>T	ENST00000285393.3	+	3	610	c.468C>T	c.(466-468)atC>atT	p.I156I	CTD-3118D11.2_ENST00000522679.1_RNA	NM_152565.1	NP_689778.1	Q8N8Y2	VA0D2_HUMAN	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2	156					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	apical plasma membrane|endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex	hydrogen ion transmembrane transporter activity|protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(9)|prostate(1)	27						CCATTCTGATCGAAACGCCAT	0.418000													55	76					0	0	1	0	0
EMILIN3	90187	broad.mit.edu	37	20	39990834	39990834	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr20:39990834C>T	ENST00000332312.3	-	4	1567	c.1375G>A	c.(1375-1377)Ggg>Agg	p.G459R		NM_052846.1	NP_443078.1	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	459						proteinaceous extracellular matrix				biliary_tract(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|prostate(2)|skin(3)|urinary_tract(2)	30		Myeloproliferative disorder(115;0.00425)				CCCCACCCCCCCATGTCCAAC	0.632000													101	89					0	0	1	0	0
DLGAP3	58512	broad.mit.edu	37	1	35370718	35370718	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:35370718G>A	ENST00000373347.1	-	3	535	c.267C>T	c.(265-267)ttC>ttT	p.F89F	DLGAP3_ENST00000235180.4_Silent_p.F89F			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	89					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				ACATCCTGGGGAAGGTGCTGC	0.692000													5	9					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89979602	89979602	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:89979602C>T	ENST00000405460.2	+	28	5960	c.5864C>T	c.(5863-5865)tCc>tTc	p.S1955F		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1955					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTCAGTGTTTCCAGTGGTTCT	0.433000													26	28					0	0	1	0	0
PTBP3	9991	broad.mit.edu	37	9	115024777	115024777	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr9:115024777G>A	ENST00000334318.6	-	6	733	c.547C>T	c.(547-549)Cct>Tct	p.P183S	PTBP3_ENST00000458258.1_Missense_Mutation_p.P186S|PTBP3_ENST00000374257.1_Missense_Mutation_p.P152S|PTBP3_ENST00000374255.2_Missense_Mutation_p.P180S|PTBP3_ENST00000343327.2_Missense_Mutation_p.P85S|PTBP3_ENST00000487997.1_5'UTR	NM_001163790.2|NM_005156.6	NP_001157262.1|NP_005147.3	O95758	ROD1_HUMAN	polypyrimidine tract binding protein 3	180	RRM 2.				anatomical structure morphogenesis|mRNA processing	nucleus	nucleotide binding|RNA binding										CGAAGCACAGGGCTCTGCCCA	0.478000													71	17					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42795740	42795740	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:42795740C>T	ENST00000572681.2	+	12	5524	c.5456C>T	c.(5455-5457)cCc>cTc	p.P1819L	CIC_ENST00000160740.3_Missense_Mutation_p.P910L|CIC_ENST00000575354.2_Missense_Mutation_p.P910L			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	910					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				CAGGCCCCGCCCCCGGGTGGC	0.642000			"""Mis, F, S"""		oligodendroglioma								146	211					0	0	1	0	0
ADAM12	8038	broad.mit.edu	37	10	127755288	127755288	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr10:127755288G>A	ENST00000368679.4	-	13	1729	c.1420C>T	c.(1420-1422)Cag>Tag	p.Q474*	ADAM12_ENST00000368676.4_Nonsense_Mutation_p.Q474*|ADAM12_ENST00000467145.1_5'UTR	NM_003474.4	NP_003465.3	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12	474	Disintegrin.				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			biliary_tract(1)|breast(7)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		TGACTCACCTGGCAGTCTTCA	0.572000													45	9					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41051174	41051174	+	Missense_Mutation	SNP	T	T	C			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:41051174T>C	ENST00000399564.4	-	13	1699	c.1249A>G	c.(1249-1251)Aac>Gac	p.N417D	MROH2B_ENST00000506092.2_5'UTR	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		TCATGAAAGTTAGTTTTCACT	0.433000													16	18					0	0	1	0	0
GFAP	2670	broad.mit.edu	37	17	42992473	42992473	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr17:42992473C>T	ENST00000253408.5	-	1	447	c.382G>A	c.(382-384)Gat>Aat	p.D128N	GFAP_ENST00000435360.2_Missense_Mutation_p.D128N|GFAP_ENST00000591327.1_5'UTR|GFAP_ENST00000588735.1_Intron|GFAP_ENST00000586793.1_Missense_Mutation_p.D128N	NM_002055.4	NP_002046.1	P14136	GFAP_HUMAN	glial fibrillary acidic protein	128	Coil 1B.|Rod.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(11)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	23		Prostate(33;0.0959)				GTGAGTTGATCGAGCCGCAGC	0.652000													37	32					0	0	1	0	0
KRTAP24-1	643803	broad.mit.edu	37	21	31655131	31655131	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr21:31655131G>A	ENST00000340345.4	-	1	145	c.120C>T	c.(118-120)agC>agT	p.S40S		NM_001085455.1	NP_001078924.1	Q3LI83	KR241_HUMAN	keratin associated protein 24-1	40						keratin filament	structural molecule activity			breast(1)|large_intestine(3)|lung(7)|urinary_tract(3)	14						CAAAGGTAGGGCTTAAATCAC	0.473000													40	54					0	0	1	0	0
USP7	7874	broad.mit.edu	37	16	9010994	9010994	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr16:9010994G>A	ENST00000344836.4	-	7	938	c.740C>T	c.(739-741)aCc>aTc	p.T247I	USP7_ENST00000381886.4_Missense_Mutation_p.T231I|USP7_ENST00000535863.1_Missense_Mutation_p.T148I	NM_003470.2	NP_003461.2	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7 (herpes virus-associated)	247					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(13)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	48						ATCCCCCTCGGTTGGCATCAT	0.348000													87	96					0	0	1	0	0
BSND	7809	broad.mit.edu	37	1	55473906	55473906	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:55473906G>A	ENST00000371265.4	+	4	822	c.568G>A	c.(568-570)Ggc>Agc	p.G190S		NM_057176.2	NP_476517.1	Q8WZ55	BSND_HUMAN	Bartter syndrome, infantile, with sensorineural deafness (Barttin)	190						basolateral plasma membrane|cytoplasm|integral to plasma membrane|protein complex				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	17						CTGTCCCCAGGGCCCTGCCCC	0.592000													18	36					0	0	1	0	0
TOP2A	7153	broad.mit.edu	37	17	38569054	38569054	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr17:38569054G>A	ENST00000423485.1	-	7	904	c.746C>T	c.(745-747)tCc>tTc	p.S249F		NM_001067.3	NP_001058.2	P11388	TOP2A_HUMAN	topoisomerase (DNA) II alpha 170kDa	249					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(9)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	39		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	ATCTTTGGTGGATCCAGCAAT	0.358000													20	15					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117667814	117667814	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr11:117667814C>T	ENST00000321322.6	-	1	162	c.161G>A	c.(160-162)aGa>aAa	p.R54K		NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	0	Ig-like C2-type 1.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		AGGCCCTATTCTCCGGGGAGG	0.692000													18	20					0	0	1	0	0
LRTM2	654429	broad.mit.edu	37	12	1943583	1943583	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:1943583C>T	ENST00000543818.1	+	5	1651	c.809C>T	c.(808-810)aCc>aTc	p.T270I	LRTM2_ENST00000299194.1_Missense_Mutation_p.T270I|CACNA2D4_ENST00000382722.5_Intron|CACNA2D4_ENST00000585708.1_Intron|CACNA2D4_ENST00000586184.1_Intron|CACNA2D4_ENST00000588077.1_Intron|CACNA2D4_ENST00000587995.1_Intron|CACNA2D4_ENST00000585732.1_Intron|LRTM2_ENST00000543730.1_3'UTR|LRTM2_ENST00000535041.1_Missense_Mutation_p.T270I	NM_001039029.2|NM_001163925.1|NM_001163926.1	NP_001034118.1|NP_001157397.1|NP_001157398.1	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	270						integral to membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	20	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			CCACCCTGCACCAAGGCCAGT	0.647000													30	24					0	0	1	0	0
WIPF3	644150	broad.mit.edu	37	7	29924127	29924127	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr7:29924127G>A	ENST00000409290.1	+	4	1017	c.1017G>A	c.(1015-1017)aaG>aaA	p.K339K	WIPF3_ENST00000409123.1_Silent_p.K339K|WIPF3_ENST00000242140.5_Silent_p.K339K	NM_001080529.2	NP_001073998.2	B8ZZV2	B8ZZV2_HUMAN	WAS/WASL interacting protein family, member 3	339										breast(2)|large_intestine(3)|lung(6)|ovary(1)	12						CACCGCAGAAGGCCGGTGCGC	0.672000													4	2					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82784829	82784829	+	Silent	SNP	A	A	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr7:82784829A>T	ENST00000423517.2	-	2	1465	c.1128T>A	c.(1126-1128)acT>acA	p.T376T	PCLO_ENST00000333891.8_Silent_p.T376T	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	336	Gln-rich.|Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TCTCTGACCCAGTCTGCTGAG	0.587000													6	79					0	0	1	0	0
PLCZ1	89869	broad.mit.edu	37	12	18872527	18872527	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:18872527C>T	ENST00000447925.2	-	5	670	c.401G>A	c.(400-402)aGa>aAa	p.R134K	PLCZ1_ENST00000435379.1_Intron|RP11-361I14.2_ENST00000536931.1_RNA|PLCZ1_ENST00000539875.1_Intron|PLCZ1_ENST00000541695.1_5'UTR|PLCZ1_ENST00000266505.7_Missense_Mutation_p.R136K	NM_033123.2	NP_149114.2	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	136					intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					ATCCATGTATCTTGTAAAACC	0.254000													13	26					0	0	1	0	0
GK5	256356	broad.mit.edu	37	3	141904626	141904626	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr3:141904626G>A	ENST00000544571.1	-	10	956	c.826C>T	c.(826-828)Cct>Tct	p.P276S	GK5_ENST00000392993.2_Intron			Q6ZS86	GLPK5_HUMAN	glycerol kinase 5 (putative)	0					glycerol metabolic process		ATP binding|glycerol kinase activity			kidney(1)|large_intestine(1)|lung(7)|urinary_tract(1)	10						TCATATCCAGGGACCTTTAAC	0.323000													14	3					0	0	1	0	0
SEMA3E	9723	broad.mit.edu	37	7	82997054	82997054	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr7:82997054C>T	ENST00000307792.3	-	17	2643	c.2176G>A	c.(2176-2178)Gaa>Aaa	p.E726K	SEMA3E_ENST00000427262.1_Missense_Mutation_p.E666K	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	726					axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				CAGTATTCTTCCACTCTCTGG	0.463000													83	194					0	0	1	0	0
SNAP25	6616	broad.mit.edu	37	20	10286841	10286841	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr20:10286841G>A	ENST00000254976.2	+	8	828	c.617G>A	c.(616-618)gGt>gAt	p.G206D	SNAP25-AS1_ENST00000453544.1_RNA|SNAP25-AS1_ENST00000421143.2_RNA|SNAP25_ENST00000495883.1_3'UTR|SNAP25_ENST00000304886.2_Missense_Mutation_p.G206D	NM_130811.2	NP_570824.1	P60880	SNP25_HUMAN	synaptosomal-associated protein, 25kDa	206					energy reserve metabolic process|glutamate secretion|neurotransmitter uptake|synaptic vesicle docking involved in exocytosis	cell junction|growth cone|perinuclear region of cytoplasm|synapse|synaptosome				endometrium(1)|large_intestine(2)|lung(8)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	18					Botulinum Toxin Type A(DB00083)	CTGGGAAGTGGTTAAGTGTGC	0.458000													26	28					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85741318	85741318	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr4:85741318G>A	ENST00000322366.6	-	12	2020	c.1613C>T	c.(1612-1614)tCa>tTa	p.S538L	WDFY3_ENST00000295888.4_Missense_Mutation_p.S538L			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	538						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GTCTTCAACTGAACTATTATT	0.338000													104	166					0	0	1	0	0
VRTN	55237	broad.mit.edu	37	14	74823854	74823854	+	Missense_Mutation	SNP	T	T	G			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr14:74823854T>G	ENST00000256362.4	+	2	609	c.368T>G	c.(367-369)aTg>aGg	p.M123R		NM_018228.2	NP_060698.2	Q9H8Y1	VRTN_HUMAN	vertebrae development associated	123					transposition, DNA-mediated		DNA binding|transposase activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(15)|ovary(5)|prostate(2)|skin(1)|urinary_tract(1)	41						CTCCAGGGCATGATCGACTCC	0.642000													27	22					0	0	1	0	0
JPH4	84502	broad.mit.edu	37	14	24040639	24040639	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr14:24040639G>A	ENST00000397118.3	-	6	2203	c.1301C>T	c.(1300-1302)tCc>tTc	p.S434F	JPH4_ENST00000356300.4_Missense_Mutation_p.S434F|JPH4_ENST00000544177.1_Missense_Mutation_p.S99F	NM_032452.2	NP_115828.2	Q96JJ6	JPH4_HUMAN	junctophilin 4	434					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane				endometrium(1)|large_intestine(2)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		CTCCGTGTCGGAACCTTCTGA	0.617000													31	9					0	0	1	0	0
WWC3	55841	broad.mit.edu	37	X	10094257	10094257	+	Nonsense_Mutation	SNP	A	A	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chrX:10094257A>T	ENST00000380861.4	+	15	2408	c.2017A>T	c.(2017-2019)Aga>Tga	p.R673*	WWC3_ENST00000454666.1_Nonsense_Mutation_p.R673*	NM_015691.3	NP_056506.2	Q9ULE0	WWC3_HUMAN	WWC family member 3	673	C2.									NS(1)|breast(3)|endometrium(10)|kidney(1)|large_intestine(11)|lung(17)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	52						CGAAGTGTTCAGAATCCCCGT	0.547000													146	40					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	42080588	42080588	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr21:42080588G>A	ENST00000400454.1	-	2	630	c.153C>T	c.(151-153)atC>atT	p.I51I		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	51	Ig-like C2-type 1.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TCACAGGAGGGATGCCTGCTG	0.587000													62	99					0	0	1	0	0
FSTL5	56884	broad.mit.edu	37	4	162307376	162307376	+	Missense_Mutation	SNP	G	G	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr4:162307376G>T	ENST00000306100.5	-	16	2503	c.2067C>A	c.(2065-2067)ttC>ttA	p.F689L	FSTL5_ENST00000379164.4_Missense_Mutation_p.F688L|RP11-234O6.2_ENST00000508189.1_RNA|FSTL5_ENST00000427802.2_Missense_Mutation_p.F679L|FSTL5_ENST00000536695.1_Missense_Mutation_p.F688L	NM_001128427.2|NM_020116.4	NP_001121899.1|NP_064501.2	Q8N475	FSTL5_HUMAN	follistatin-like 5	689						extracellular region	calcium ion binding			central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		CATCACTATTGAACCCAATGA	0.488000													19	94					8.10497e-08	8.16205e-08	1	1	0
MYH8	4626	broad.mit.edu	37	17	10298460	10298460	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr17:10298460C>T	ENST00000403437.2	-	34	5046	c.4952G>A	c.(4951-4953)gGa>gAa	p.G1651E	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1651					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						CTTCAGGATTCCTTGGGTGTT	0.443000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				98	145					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82545021	82545021	+	Missense_Mutation	SNP	A	A	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr7:82545021A>T	ENST00000423517.2	-	7	12618	c.12281T>A	c.(12280-12282)tTc>tAc	p.F4094Y	PCLO_ENST00000437081.1_Missense_Mutation_p.F814Y|PCLO_ENST00000333891.8_Missense_Mutation_p.F4094Y	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4025					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						AGGTGCTAGGAAATCTGTCAC	0.458000													15	16					0	0	1	0	0
GLRB	2743	broad.mit.edu	37	4	157999217	157999217	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr4:157999217C>T	ENST00000264428.4	+	2	311	c.41C>T	c.(40-42)tCc>tTc	p.S14F	GLRB_ENST00000512619.1_Missense_Mutation_p.S14F|GLRB_ENST00000541722.1_Missense_Mutation_p.S14F|GLRB_ENST00000509282.1_Missense_Mutation_p.S14F	NM_000824.4	NP_000815.1	P48167	GLRB_HUMAN	glycine receptor, beta	14					nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(6)|skin(5)|upper_aerodigestive_tract(1)	27	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	ATTTTAATTTCCTTGTGGGTG	0.338000													20	24					0	0	1	0	0
ZNF404	342908	broad.mit.edu	37	19	44378101	44378101	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:44378101C>T	ENST00000587539.1	-	3	264	c.265G>A	c.(265-267)Gac>Aac	p.D89N	ZNF404_ENST00000324394.6_Missense_Mutation_p.D87N	NM_001033719.2	NP_001028891.2	Q494X3	ZN404_HUMAN	zinc finger protein 404	89					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|skin(1)|stomach(2)|urinary_tract(1)	17		Prostate(69;0.0352)				TACTGTGGGTCAGTTCTGAAA	0.333000													80	133					0	0	1	0	0
SCUBE1	80274	broad.mit.edu	37	22	43608537	43608537	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr22:43608537C>T	ENST00000360835.3	-	17	2241	c.2115G>A	c.(2113-2115)gtG>gtA	p.V705V		NM_173050.3	NP_766638.2	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	705					adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(4)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_neural(38;0.0414)|Ovarian(80;0.07)				GGTACGTGCCCACGGGGCAGG	0.662000													5	5					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106431422	106431422	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr8:106431422G>A	ENST00000407775.2	+	2	341	c.91G>A	c.(91-93)Gaa>Aaa	p.E31K	ZFPM2_ENST00000520492.1_5'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	31					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			TCCATCAGAGGAAACAGACAT	0.423000													43	41					0	0	1	0	0
DYRK4	8798	broad.mit.edu	37	12	4702298	4702298	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:4702298G>A	ENST00000540757.2	+	4	409	c.249G>A	c.(247-249)acG>acA	p.T83T	DYRK4_ENST00000010132.5_Silent_p.T83T|DYRK4_ENST00000543431.1_Silent_p.T83T	NM_003845.1	NP_003836.1	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4	83						Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27			Colorectal(7;0.103)			TTAGCAAGACGAGTTTTGATG	0.522000													30	33					0	0	1	0	0
BDKRB2	624	broad.mit.edu	37	14	96706581	96706581	+	Translation_Start_Site	SNP	A	A	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr14:96706581A>T	ENST00000542454.2	+	0	2923				BDKRB2_ENST00000554311.1_Intron|RP11-404P21.8_ENST00000553811.1_Intron|BDKRB2_ENST00000306005.3_Intron|BDKRB2_ENST00000539359.1_Intron			P30411	BKRB2_HUMAN	bradykinin receptor B2						arachidonic acid secretion|elevation of cytosolic calcium ion concentration|transmembrane receptor protein tyrosine kinase signaling pathway	endosome|integral to plasma membrane	bradykinin receptor activity|phosphatidylinositol phospholipase C activity|protease binding|protein heterodimerization activity|type 1 angiotensin receptor binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(5)|lung(7)|ovary(3)|skin(1)	24		all_cancers(154;0.0678)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.226)		CAGGGGAGTCAGGTGCACTGG	0.587000													10	80					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29052363	29052363	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr18:29052363G>A	ENST00000257189.4	+	13	2097	c.2014G>A	c.(2014-2016)Gaa>Aaa	p.E672K		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	672					cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GTGGGGAATTGAAGGAGCCCA	0.423000													27	37					0	0	1	0	0
KLHL40	131377	broad.mit.edu	37	3	42733407	42733407	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr3:42733407C>T	ENST00000287777.4	+	6	1888	c.1788C>T	c.(1786-1788)gtC>gtT	p.V596V		NM_152393.2	NP_689606.2			kelch-like family member 40																		GGGAGGGTGTCCTGCGGGAGA	0.562000													67	15					0	0	1	0	0
CIB4	130106	broad.mit.edu	37	2	26806672	26806672	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:26806672C>T	ENST00000288861.4	-	5	476	c.423G>A	c.(421-423)atG>atA	p.M141I	CIB4_ENST00000405346.3_5'UTR	NM_001029881.1	NP_001025052.1	A0PJX0	CIB4_HUMAN	calcium and integrin binding family member 4	141	EF-hand 3.						calcium ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCGTGAGGTCCATCAGGAGGT	0.572000													51	72					0	0	1	0	0
KCNMB2	10242	broad.mit.edu	37	3	178546007	178546007	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr3:178546007C>T	ENST00000432997.1	+	4	621	c.269C>T	c.(268-270)tCc>tTc	p.S90F	RP11-385J1.2_ENST00000432385.1_RNA|KCNMB2_ENST00000358316.3_Missense_Mutation_p.S90F|RP11-385J1.2_ENST00000425330.1_RNA|KCNMB2_ENST00000452583.1_Missense_Mutation_p.S90F|RP11-385J1.2_ENST00000437488.1_RNA|KCNMB2_ENST00000420517.2_Missense_Mutation_p.S90F|RP11-385J1.2_ENST00000451742.1_RNA	NM_005832.3	NP_005823.1	Q9Y691	KCMB2_HUMAN	potassium large conductance calcium-activated channel, subfamily M, beta member 2	90					detection of calcium ion|platelet activation|regulation of action potential in neuron|regulation of vasoconstriction	voltage-gated potassium channel complex	calcium-activated potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			NS(2)|endometrium(4)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	12	all_cancers(143;5.38e-18)|Ovarian(172;0.00769)|Breast(254;0.125)		OV - Ovarian serous cystadenocarcinoma(80;1.32e-27)|GBM - Glioblastoma multiforme(14;0.0321)|BRCA - Breast invasive adenocarcinoma(182;0.0841)			CTGAATGCGTCCATCACGGAA	0.493000													66	13					0	0	1	0	0
BTNL8	79908	broad.mit.edu	37	5	180377187	180377187	+	Silent	SNP	G	G	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:180377187G>T	ENST00000340184.4	+	8	1352	c.1146G>T	c.(1144-1146)ctG>ctT	p.L382L	BTNL8_ENST00000231229.4_3'UTR|BTNL8_ENST00000533815.2_Silent_p.L198L|BTNL8_ENST00000508408.1_3'UTR|BTNL8_ENST00000511704.1_Silent_p.L266L|BTNL8_ENST00000400707.3_Silent_p.L257L|BTNL8_ENST00000505126.1_Silent_p.L175L	NM_001040462.2	NP_001035552.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8	382	B30.2/SPRY.					integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCCTCAGACTGAATGGAGAAC	0.498000													58	65					7.06795e-37	7.25395e-37	1	1	0
EPN1	29924	broad.mit.edu	37	19	56196873	56196873	+	Missense_Mutation	SNP	C	C	G			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:56196873C>G	ENST00000411543.2	+	4	1220	c.673C>G	c.(673-675)Cgc>Ggc	p.R225G	EPN1_ENST00000591743.1_3'UTR|EPN1_ENST00000270460.6_Missense_Mutation_p.R114G|EPN1_ENST00000085079.7_Missense_Mutation_p.R114G	NM_001130071.1	NP_001123543.1	Q9Y6I3	EPN1_HUMAN	epsin 1	114					endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|cytoplasm|nucleus|plasma membrane	lipid binding	p.R114S(1)|p.R225S(1)		endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|skin(1)	17		Colorectal(82;0.00244)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.112)		GTACGTGGACCGCGACGGCAA	0.647000													15	25					0	0	1	0	0
FIBIN	387758	broad.mit.edu	37	11	27016585	27016585	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr11:27016585C>T	ENST00000318627.2	+	1	958	c.512C>T	c.(511-513)tCc>tTc	p.S171F		NM_203371.1	NP_976249.1	Q8TAL6	FIBIN_HUMAN	fin bud initiation factor homolog (zebrafish)	171						extracellular region|Golgi apparatus				breast(1)|endometrium(2)|lung(7)|upper_aerodigestive_tract(1)	11						CACACCAGGTCCCTGCTGAAG	0.597000													43	57					0	0	1	0	0
RFPL1S	10740	broad.mit.edu	37	22	29833664	29833664	+	RNA	SNP	A	A	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr22:29833664A>T	ENST00000461286.2	-	0	4712					NR_002727.2																						CTTCCGCACAAGACCTGAGCG	0.542000													13	13					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141625327	141625327	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:141625327G>A	ENST00000389484.3	-	27	5382	c.4411C>T	c.(4411-4413)Cat>Tat	p.H1471Y		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1471					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GCAAAGGGATGGGAAAGGTAT	0.428000										TSP Lung(27;0.18)			54	56					0	0	1	0	0
RABGAP1L	9910	broad.mit.edu	37	1	174219699	174219699	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:174219699C>T	ENST00000251507.4	+	6	978	c.804C>T	c.(802-804)acC>acT	p.T268T	RABGAP1L_ENST00000367689.3_5'UTR|RABGAP1L_ENST00000357444.6_Silent_p.T231T	NM_014857.4	NP_055672.3	Q5R372	RBG1L_HUMAN	RAB GTPase activating protein 1-like	268	PID.				regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			NS(1)|breast(2)|endometrium(4)|kidney(5)|large_intestine(7)|lung(21)|ovary(2)|prostate(1)|skin(2)	45						TTATTCCTACCCCCGACAGTG	0.378000													33	58					0	0	1	0	0
ZNF276	92822	broad.mit.edu	37	16	89789952	89789952	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr16:89789952G>A	ENST00000289816.5	+	4	928	c.616G>A	c.(616-618)Gat>Aat	p.D206N	ZNF276_ENST00000446326.2_Silent_p.G77G|ZNF276_ENST00000443381.2_Missense_Mutation_p.D281N|ZNF276_ENST00000568064.1_Silent_p.G199G	NM_152287.3	NP_689500.2	Q8N554	ZN276_HUMAN	zinc finger protein 276	281					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)	14		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		GAACCCTGGGGATGCCCCTCA	0.662000													30	26					0	0	1	0	0
SMTN	6525	broad.mit.edu	37	22	31487256	31487256	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr22:31487256C>T	ENST00000333137.7	+	10	1465	c.1247C>T	c.(1246-1248)cCc>cTc	p.P416L	SMTN_ENST00000358743.1_Missense_Mutation_p.P416L|SMTN_ENST00000347557.2_Missense_Mutation_p.P416L	NM_001207018.1|NM_134269.2	NP_001193947.1|NP_599031.1	P53814	SMTN_HUMAN	smoothelin	416					muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			breast(2)|endometrium(2)|large_intestine(5)|lung(9)|ovary(3)|pancreas(1)|prostate(3)	25						GAGGAGGGCCCCAGGGGGCGG	0.701000													5	12					0	0	1	0	0
PHLPP1	23239	broad.mit.edu	37	18	60582234	60582234	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr18:60582234C>T	ENST00000400316.4	+	9	3042	c.1261C>T	c.(1261-1263)Cct>Tct	p.P421S	PHLPP1_ENST00000262719.5_Missense_Mutation_p.P933S	NM_194449.3	NP_919431.2	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein phosphatase 1	933					apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity			endometrium(2)|kidney(2)|lung(13)	17						ATGTGAACTTCCTGCCCGGTG	0.373000													17	16					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32745285	32745285	+	Missense_Mutation	SNP	A	A	G			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr13:32745285A>G	ENST00000380250.3	+	18	2525	c.2029A>G	c.(2029-2031)Atg>Gtg	p.M677V		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	677					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		AGTAAATGATATGCATCACAC	0.448000													50	63					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52379590	52379590	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr3:52379590G>A	ENST00000420323.2	+	10	1785	c.1524G>A	c.(1522-1524)gaG>gaA	p.E508E		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	508	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CACGGCCAGAGGTCATCACGG	0.602000													7	0					0	0	1	0	0
PATL1	219988	broad.mit.edu	37	11	59423436	59423436	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr11:59423436C>T	ENST00000300146.9	-	7	890	c.806G>A	c.(805-807)gGa>gAa	p.G269E		NM_152716.2	NP_689929.2	Q86TB9	PATL1_HUMAN	protein associated with topoisomerase II homolog 1 (yeast)	269	Pro-rich.|Region N; interaction with decapping machinery.				cytoplasmic mRNA processing body assembly|deadenylation-dependent decapping of nuclear-transcribed mRNA	cytoplasmic mRNA processing body	protein binding|RNA binding			central_nervous_system(1)|endometrium(2)|lung(5)|ovary(1)|prostate(2)	11						TACCTGTGCTCCTCCAAGAAG	0.443000													3	18					0	0	1	0	0
ZNF592	9640	broad.mit.edu	37	15	85326436	85326436	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr15:85326436C>T	ENST00000299927.3	+	1	552	c.530C>T	c.(529-531)gCt>gTt	p.A177V	ZNF592_ENST00000560079.2_Missense_Mutation_p.A177V			Q92610	ZN592_HUMAN	zinc finger protein 592	177					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GGGTGCGGGGCTGTGGGAGGC	0.517000													92	136					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126411653	126411653	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr4:126411653C>T	ENST00000394329.3	+	17	13689	c.13676C>T	c.(13675-13677)cCt>cTt	p.P4559L	FAT4_ENST00000335110.5_Missense_Mutation_p.P2800L	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4559					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.P4502H(1)|p.P4559H(1)		NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TTTGATGACCCTGACAATATC	0.468000													38	63					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31324822	31324822	+	Silent	SNP	T	T	C			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr18:31324822T>C	ENST00000269197.5	+	12	5010	c.5010T>C	c.(5008-5010)tcT>tcC	p.S1670S		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1670					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						CTGTGAAATCTGAACTTCACG	0.488000													5	87					0	0	1	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6051580	6051580	+	Missense_Mutation	SNP	A	A	G			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr4:6051580A>G	ENST00000409021.3	-	15	2377	c.1928T>C	c.(1927-1929)cTt>cCt	p.L643P	JAKMIP1_ENST00000409371.3_Missense_Mutation_p.L458P	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	416					protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TTTCTTCATAAGTTCAGAAAC	0.428000													25	22					0	0	1	0	0
SEMA7A	8482	broad.mit.edu	37	15	74709990	74709990	+	Silent	SNP	G	G	A	rs142309393	byFrequency	TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr15:74709990G>A	ENST00000261918.4	-	5	1040	c.492C>T	c.(490-492)ggC>ggT	p.G164G	SEMA7A_ENST00000543145.2_Silent_p.G150G|SEMA7A_ENST00000542748.1_5'UTR	NM_003612.3	NP_003603.1	O75326	SEM7A_HUMAN	semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)	164	Sema.				axon guidance|immune response|inflammatory response|integrin-mediated signaling pathway|positive regulation of axon extension|positive regulation of ERK1 and ERK2 cascade|positive regulation of macrophage cytokine production|regulation of inflammatory response	anchored to membrane|external side of plasma membrane	receptor activity			breast(3)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(3)|lung(12)|upper_aerodigestive_tract(1)	30						CTCTCATCTCGCCAAGTGGCA	0.612000													25	38					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196740510	196740510	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:196740510G>A	ENST00000312428.6	-	38	6275	c.6175C>T	c.(6175-6177)Ccc>Tcc	p.P2059S		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2059	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AACTCAATGGGAGGTTGAGCC	0.403000													44	39					0	0	1	0	0
RBM42	79171	broad.mit.edu	37	19	36124044	36124044	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:36124044C>T	ENST00000262633.4	+	6	679	c.574C>T	c.(574-576)Ctc>Ttc	p.L192F	RBM42_ENST00000586618.1_Intron|RBM42_ENST00000589871.1_Missense_Mutation_p.L170F|RBM42_ENST00000589559.1_Missense_Mutation_p.L163F|RBM42_ENST00000588161.1_Missense_Mutation_p.L162F|RBM42_ENST00000592202.1_Missense_Mutation_p.L138F|RBM42_ENST00000360475.4_Missense_Mutation_p.L163F	NM_024321.3	NP_077297.2	Q9BTD8	RBM42_HUMAN	RNA binding motif protein 42	192	Pro-rich.					cytoplasm|nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(3)|large_intestine(7)|lung(9)|prostate(1)	21	all_lung(56;1.58e-07)|Lung NSC(56;2.43e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			TCACCAGGCCCTCGTGGGCCC	0.706000													119	140					0	0	1	0	0
GATA1	2623	broad.mit.edu	37	X	48652655	48652655	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chrX:48652655C>T	ENST00000376665.3	+	6	1077	c.985C>T	c.(985-987)Ccc>Tcc	p.P329S	GATA1_ENST00000376670.3_3'UTR			P15976	GATA1_HUMAN	GATA binding protein 1 (globin transcription factor 1)	0					basophil differentiation|eosinophil differentiation|erythrocyte development|megakaryocyte differentiation|platelet aggregation|platelet formation|positive regulation of anti-apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|regulation of glycoprotein biosynthetic process|transcription from RNA polymerase II promoter	nuclear membrane|nucleolus|nucleoplasm	C2H2 zinc finger domain binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(259)|large_intestine(8)|lung(9)|prostate(1)	283						GTCTCTGGGCCCCAGGCACCC	0.532000			"""Mis, F"""		megakaryoblastic leukemia of Downs Syndrome								11	5					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42635229	42635229	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr20:42635229C>T	ENST00000358131.5	+	3	443	c.235C>T	c.(235-237)Ccc>Tcc	p.P79S	TOX2_ENST00000423191.1_Missense_Mutation_p.P28S|TOX2_ENST00000341197.3_Missense_Mutation_p.P70S|TOX2_ENST00000372999.1_Missense_Mutation_p.P28S	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	79	Required for transcriptional activation (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CTATGAGATCCCCCCGATAAC	0.582000													44	69					0	0	1	0	0
CHRNA9	55584	broad.mit.edu	37	4	40351137	40351137	+	Nonsense_Mutation	SNP	G	G	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr4:40351137G>T	ENST00000310169.2	+	4	743	c.604G>T	c.(604-606)Gaa>Taa	p.E202*		NM_017581.3	NP_060051.2	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9 (neuronal)	202					elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(4)|stomach(1)	33					Nicotine(DB00184)	TGAAGATGTGGAATGGGAGGT	0.512000													153	147					1.9257e-63	1.98587e-63	1	1	0
CLCA4	22802	broad.mit.edu	37	1	87025615	87025615	+	Splice_Site	SNP	G	G	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:87025615G>T	ENST00000370563.3	+	2	202	c.159_splice	c.e2-1	p.D54_splice	CLCA4_ENST00000263723.5_5'UTR	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	54						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		TTAATGACAGGATATGGTGAC	0.348000													19	86					7.45023e-12	7.5559e-12	1	1	0
PARM1	25849	broad.mit.edu	37	4	75938153	75938153	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr4:75938153G>A	ENST00000307428.7	+	2	774	c.562G>A	c.(562-564)Gga>Aga	p.G188R	RP11-44F21.2_ENST00000513770.1_RNA|PARM1_ENST00000513238.1_Intron	NM_015393.3	NP_056208.2	Q6UWI2	PARM1_HUMAN	prostate androgen-regulated mucin-like protein 1	188					positive regulation of telomerase activity	early endosome|endosome membrane|Golgi membrane|integral to membrane|late endosome|plasma membrane				cervix(1)|endometrium(2)|lung(4)|ovary(1)	8						CCAACCCACTGGAGCTCCAAC	0.567000													141	153					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128488930	128488930	+	Missense_Mutation	SNP	T	T	G			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr7:128488930T>G	ENST00000325888.8	+	28	5082	c.4821T>G	c.(4819-4821)agT>agG	p.S1607R	FLNC_ENST00000346177.6_Missense_Mutation_p.S1607R	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1607					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CGGACATGAGTGGCCGGTACA	0.602000													79	67					0	0	1	0	0
VSTM1	284415	broad.mit.edu	37	19	54545604	54545604	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:54545604G>A	ENST00000338372.2	-	5	589	c.414C>T	c.(412-414)gtC>gtT	p.V138V	VSTM1_ENST00000425006.2_3'UTR|VSTM1_ENST00000376626.1_Intron|VSTM1_ENST00000366170.2_Silent_p.V50V	NM_198481.3	NP_940883.2	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	138						integral to membrane				breast(1)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		TGAAGATGGCGACAAAGATGG	0.532000													21	27					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141457909	141457909	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:141457909C>T	ENST00000389484.3	-	41	7680	c.6709G>A	c.(6709-6711)Ggt>Agt	p.G2237S		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2237					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.G2237R(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CGGTTGGTACCTTTTCTTCTT	0.348000										TSP Lung(27;0.18)			69	74					0	0	1	0	0
C15orf41	84529	broad.mit.edu	37	15	36983917	36983917	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr15:36983917G>A	ENST00000566621.1	+	6	628	c.378G>A	c.(376-378)cgG>cgA	p.R126R	C15orf41_ENST00000567389.1_Silent_p.R28R|C15orf41_ENST00000437989.2_Silent_p.R126R|C15orf41_ENST00000338183.4_Silent_p.R28R|C15orf41_ENST00000569302.1_Silent_p.R126R|C15orf41_ENST00000562877.1_Silent_p.R28R	NM_001130010.1	NP_001123482.1	Q9Y2V0	CO041_HUMAN	chromosome 15 open reading frame 41	126							protein binding			kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)	12		all_epithelial(112;3.06e-10)|Lung NSC(122;6.48e-08)|all_lung(180;8.31e-07)|Melanoma(134;0.222)		all cancers(64;1.76e-19)|GBM - Glioblastoma multiforme(113;5.03e-07)|BRCA - Breast invasive adenocarcinoma(123;0.11)		GTATGCTACGGGACCCTTCTC	0.398000													7	10					0	0	1	0	0
IDO2	169355	broad.mit.edu	37	8	39872921	39872921	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr8:39872921G>A	ENST00000502986.2	+	11	1305	c.1063G>A	c.(1063-1065)Gag>Aag	p.E355K	IDO2_ENST00000389060.4_Missense_Mutation_p.E342K|IDO2_ENST00000343295.4_3'UTR	NM_194294.2	NP_919270.2	Q6ZQW0	I23O2_HUMAN	indoleamine 2,3-dioxygenase 2	342					tryptophan catabolic process to kynurenine	cytosol	heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)	18						GGCCCTGGCAGAGCTGCGGAG	0.547000													31	33					0	0	1	0	0
IGHV4-28	28400	broad.mit.edu	37	14	106780757	106780757	+	RNA	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr14:106780757G>A	ENST00000390612.2	-	0	178																											GAGGGACAGGGTGTCCGAAGG	0.627000													44	83					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32624370	32624370	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr21:32624370C>T	ENST00000286827.3	-	6	1570	c.1099G>A	c.(1099-1101)Ggc>Agc	p.G367S	TIAM1_ENST00000541036.1_Missense_Mutation_p.G367S|TIAM1_ENST00000469412.1_5'UTR	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	367					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						CTGTCGCTGCCCACAAAGGCC	0.642000													107	149					0	0	1	0	0
ADAM7	8756	broad.mit.edu	37	8	24350570	24350570	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr8:24350570G>A	ENST00000175238.6	+	16	1753	c.1670G>A	c.(1669-1671)gGa>gAa	p.G557E	ADAM7_ENST00000520720.1_Missense_Mutation_p.G329E|RP11-561E1.1_ENST00000519364.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA|RP11-624C23.1_ENST00000519689.1_RNA|ADAM7_ENST00000380789.1_Missense_Mutation_p.G557E	NM_003817.3	NP_003808.2	Q9H2U9	ADAM7_HUMAN	ADAM metallopeptidase domain 7	557	Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(24)|ovary(1)|skin(15)	64		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		GTCAGATGTGGAAAGATCTAC	0.448000													32	35					0	0	1	0	0
APOL4	80832	broad.mit.edu	37	22	36587498	36587498	+	Silent	SNP	G	G	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr22:36587498G>T	ENST00000332987.1	-	7	1091	c.669C>A	c.(667-669)ccC>ccA	p.P223P	APOL4_ENST00000429038.2_3'UTR|APOL4_ENST00000479929.1_5'UTR|APOL4_ENST00000405511.1_3'UTR|APOL4_ENST00000404685.3_3'UTR|APOL4_ENST00000352371.1_Silent_p.P226P			Q9BPW4	APOL4_HUMAN	apolipoprotein L, 4	227			R -> H (in dbSNP:rs2227168).		lipid metabolic process|lipid transport|lipoprotein metabolic process	extracellular region	lipid binding			lung(1)	1						AAAGCACATTGGGTGTGATGT	0.473000													31	32					2.61193e-14	2.65526e-14	1	1	0
DNAH5	1767	broad.mit.edu	37	5	13769624	13769624	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:13769624C>T	ENST00000265104.4	-	57	9810	c.9706G>A	c.(9706-9708)Gat>Aat	p.D3236N	DNAH5_ENST00000504001.3_5'UTR	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3236	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TCGGCTTTATCGTTGGCCACT	0.418000									Kartagener syndrome				89	98					0	0	1	0	0
CD200R1	131450	broad.mit.edu	37	3	112648265	112648265	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr3:112648265C>T	ENST00000471858.1	-	3	455	c.223G>A	c.(223-225)Gaa>Aaa	p.E75K	CD200R1_ENST00000490004.1_Missense_Mutation_p.E75K|CD200R1_ENST00000440122.2_Missense_Mutation_p.E98K|CD200R1_ENST00000308611.3_Missense_Mutation_p.E98K|CD200R1_ENST00000295863.4_Missense_Mutation_p.E53K	NM_170780.2	NP_740750.1	Q8TD46	MO2R1_HUMAN	CD200 receptor 1	75	Ig-like V-type.				interspecies interaction between organisms|regulation of immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	26						AGGATTATTTCCCATGTTATT	0.413000													69	5					0	0	1	0	0
CATSPER1	117144	broad.mit.edu	37	11	65787838	65787838	+	Missense_Mutation	SNP	C	C	T	rs12720434		TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr11:65787838C>T	ENST00000312106.5	-	8	2151	c.2014G>A	c.(2014-2016)Gat>Aat	p.D672N		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	672					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						TGGAAGCTATCCACCAGGACA	0.612000													65	128					0	0	1	0	0
IRX6	79190	broad.mit.edu	37	16	55361531	55361531	+	Silent	SNP	C	C	T	rs34343392		TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr16:55361531C>T	ENST00000290552.7	+	4	1779	c.447C>T	c.(445-447)cgC>cgT	p.R149R	RP11-26L20.3_ENST00000558730.2_RNA|IRX6_ENST00000558315.1_3'UTR	NM_024335.2	NP_077311.2	P78412	IRX6_HUMAN	iroquois homeobox 6	149						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(2)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33						GCGCCGGTCGCCGAAAGAACG	0.572000													21	22					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41966562	41966562	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:41966562G>A	ENST00000298919.7	+	10	1589	c.1201G>A	c.(1201-1203)Gga>Aga	p.G401R	PDZRN4_ENST00000539469.2_Missense_Mutation_p.G403R|PDZRN4_ENST00000402685.2_Missense_Mutation_p.G661R			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	661							ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				GGAGCAAGAGGGAGTGGAGCA	0.453000													32	35					0	0	1	0	0
ALB	213	broad.mit.edu	37	4	74274453	74274453	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr4:74274453G>A	ENST00000295897.4	+	4	502	c.413G>A	c.(412-414)cGa>cAa	p.R138Q	ALB_ENST00000509063.1_Missense_Mutation_p.R138Q|ALB_ENST00000415165.2_Intron|ALB_ENST00000503124.1_Intron|ALB_ENST00000401494.3_Intron|ALB_ENST00000505649.1_3'UTR	NM_000477.5	NP_000468.1	P02768	ALBU_HUMAN	albumin	138	Albumin 1.		R -> G (in Yanomama-2).		bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(6)|liver(9)|lung(16)|ovary(3)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	48	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin iodonated(DB00064)|Serum albumin(DB00096)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	AACCTCCCCCGATTGGTGAGA	0.398000													18	17					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1081807	1081807	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr11:1081807G>A	ENST00000441003.2	+	13	1762	c.1735G>A	c.(1735-1737)Gag>Aag	p.E579K	MUC2_ENST00000359061.5_Missense_Mutation_p.E579K	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	579	VWFD 2.					inner mucus layer|outer mucus layer	protein binding	p.E579Q(2)		NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CCTGAACATCGAGAGCGGTGA	0.662000													27	33					0	0	1	0	0
CARF	79800	broad.mit.edu	37	2	203846897	203846897	+	Missense_Mutation	SNP	A	A	G			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:203846897A>G	ENST00000320443.8	+	15	2835	c.1792A>G	c.(1792-1794)Ata>Gta	p.I598V	WDR12_ENST00000477723.1_Intron|CARF_ENST00000402905.2_Missense_Mutation_p.I598V|CARF_ENST00000414439.1_Missense_Mutation_p.I496V|CARF_ENST00000545253.1_Missense_Mutation_p.I510V|CARF_ENST00000438828.2_Missense_Mutation_p.I598V|CARF_ENST00000428585.1_Missense_Mutation_p.I522V|CARF_ENST00000545262.1_Missense_Mutation_p.I522V					calcium responsive transcription factor																		TCTGGATACAATAGGAAGTGC	0.418000													24	55					0	0	1	0	0
MEGF10	84466	broad.mit.edu	37	5	126758424	126758424	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:126758424C>T	ENST00000274473.6	+	14	1920	c.1653C>T	c.(1651-1653)caC>caT	p.H551H	MEGF10_ENST00000508365.1_Silent_p.H551H|MEGF10_ENST00000418761.2_Silent_p.H551H|MEGF10_ENST00000503335.2_Silent_p.H551H	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	551	EGF-like 10.|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		ATGGCTGCCACCCTACCACGG	0.587000													19	51					0	0	1	0	0
PDE1B	5153	broad.mit.edu	37	12	54971042	54971042	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:54971042C>T	ENST00000243052.3	+	15	1977	c.1541C>T	c.(1540-1542)tCc>tTc	p.S514F	PDE1B_ENST00000538346.1_Missense_Mutation_p.S473F|PDE1B_ENST00000550620.1_Missense_Mutation_p.S494F|PPP1R1A_ENST00000547431.1_3'UTR|PDE1B_ENST00000394277.3_3'UTR	NM_000924.3	NP_000915.1	Q01064	PDE1B_HUMAN	phosphodiesterase 1B, calmodulin-dependent	514					activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(4)	31						GACGAGCTGTCCCCCTGTGAA	0.552000													111	105					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10542883	10542883	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr17:10542883C>T	ENST00000583535.1	-	23	3006	c.2919G>A	c.(2917-2919)gaG>gaA	p.E973E	MYH3_ENST00000226209.7_Silent_p.E973E	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	973					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						ATACCTTGTTCTCTGTGGCAT	0.398000													110	171					0	0	1	0	0
PLCH2	9651	broad.mit.edu	37	1	2435743	2435743	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:2435743C>T	ENST00000419816.2	+	22	3616	c.3342C>T	c.(3340-3342)ccC>ccT	p.P1114P	PLCH2_ENST00000378488.3_Silent_p.P1078P|PLCH2_ENST00000378483.2_3'UTR|PLCH2_ENST00000449969.1_3'UTR|PLCH2_ENST00000378486.3_Silent_p.P1114P			O75038	PLCH2_HUMAN	phospholipase C, eta 2	1114					intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(3)|skin(1)	20	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		TGGCCGCTCCCTTTCCAGCTC	0.692000													15	14					0	0	1	0	0
YIPF2	78992	broad.mit.edu	37	19	11038601	11038601	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:11038601G>A	ENST00000586748.1	-	3	238	c.66C>T	c.(64-66)acC>acT	p.T22T	YIPF2_ENST00000590329.1_Silent_p.T22T|YIPF2_ENST00000253031.2_Silent_p.T22T			Q9BWQ6	YIPF2_HUMAN	Yip1 domain family, member 2	22						integral to membrane|transport vesicle				cervix(1)|endometrium(1)|lung(3)|ovary(2)	7						CTGCATCTGGGGTGTCAGCCA	0.602000													54	73					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	100141879	100141879	+	Silent	SNP	C	C	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr11:100141879C>A	ENST00000524871.1	+	18	2510	c.2220C>A	c.(2218-2220)ccC>ccA	p.P740P	CNTN5_ENST00000528682.1_Silent_p.P740P|CNTN5_ENST00000418526.2_Silent_p.P666P|CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000527185.1_Silent_p.P740P|CNTN5_ENST00000279463.3_Silent_p.P740P	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	740	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		ACCTAAATCCCTGGGTGGAAT	0.453000													31	36					9.04072e-19	9.21251e-19	1	1	0
DCUN1D4	23142	broad.mit.edu	37	4	52752763	52752763	+	Missense_Mutation	SNP	A	A	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr4:52752763A>T	ENST00000334635.5	+	6	553	c.373A>T	c.(373-375)Atg>Ttg	p.M125L	DCUN1D4_ENST00000381441.3_Missense_Mutation_p.M125L|DCUN1D4_ENST00000381437.4_Missense_Mutation_p.M65L|DCUN1D4_ENST00000451288.2_Missense_Mutation_p.M169L	NM_001040402.1	NP_001035492.1	Q92564	DCNL4_HUMAN	DCN1, defective in cullin neddylation 1, domain containing 4	125	DCUN1.									endometrium(2)|large_intestine(2)|lung(2)|ovary(2)|skin(1)	9			GBM - Glioblastoma multiforme(4;1.93e-11)|LUSC - Lung squamous cell carcinoma(32;0.00654)			CCCTGAAGGCATGGAGAAATT	0.363000													43	62					0	0	1	0	0
BCAM	4059	broad.mit.edu	37	19	45324025	45324025	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:45324025C>T	ENST00000270233.6	+	14	1849	c.1827C>T	c.(1825-1827)ctC>ctT	p.L609L		NM_001013257.2|NM_005581.4	NP_001013275.1|NP_005572.2	P50895	BCAM_HUMAN	basal cell adhesion molecule (Lutheran blood group)	609					cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	22	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				CCGGCCTTCTCATGGGAGGTG	0.731000													3	4					0	0	1	0	0
ATP8B4	79895	broad.mit.edu	37	15	50168634	50168634	+	Silent	SNP	G	G	A	rs150358448		TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr15:50168634G>A	ENST00000284509.6	-	25	3009	c.2868C>T	c.(2866-2868)ttC>ttT	p.F956F	ATP8B4_ENST00000559829.1_Silent_p.F956F	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	956					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity	p.F956F(1)		breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		ACACGCAAATGAAAAATTTAC	0.458000													29	42					0	0	1	0	0
PTBP3	9991	broad.mit.edu	37	9	115024776	115024776	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr9:115024776G>A	ENST00000334318.6	-	6	734	c.548C>T	c.(547-549)cCt>cTt	p.P183L	PTBP3_ENST00000458258.1_Missense_Mutation_p.P186L|PTBP3_ENST00000374257.1_Missense_Mutation_p.P152L|PTBP3_ENST00000374255.2_Missense_Mutation_p.P180L|PTBP3_ENST00000343327.2_Missense_Mutation_p.P85L|PTBP3_ENST00000487997.1_5'UTR	NM_001163790.2|NM_005156.6	NP_001157262.1|NP_005147.3	O95758	ROD1_HUMAN	polypyrimidine tract binding protein 3	180	RRM 2.				anatomical structure morphogenesis|mRNA processing	nucleus	nucleotide binding|RNA binding										TCGAAGCACAGGGCTCTGCCC	0.478000													71	17					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62299326	62299326	+	Missense_Mutation	SNP	T	T	C			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr11:62299326T>C	ENST00000378024.4	-	5	2837	c.2563A>G	c.(2563-2565)Aaa>Gaa	p.K855E	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	855					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TTGGCACTTTTAAGTTCAACA	0.443000													170	233					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20944734	20944734	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr16:20944734C>T	ENST00000261383.3	-	62	12092	c.12093G>A	c.(12091-12093)acG>acA	p.T4031T	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	4031					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CAATCTGCATCGTTTTCCTGT	0.507000													57	74					0	0	1	0	0
SMARCA2	6595	broad.mit.edu	37	9	2182173	2182173	+	Silent	SNP	A	A	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr9:2182173A>T	ENST00000382203.1	+	31	4601	c.4392A>T	c.(4390-4392)ctA>ctT	p.L1464L	SMARCA2_ENST00000357248.2_Silent_p.L1446L|SMARCA2_ENST00000382186.1_Silent_p.L128L|SMARCA2_ENST00000382185.1_Silent_p.L110L|SMARCA2_ENST00000324954.5_Silent_p.L110L|SMARCA2_ENST00000302401.3_Silent_p.L152L|SMARCA2_ENST00000382194.1_Silent_p.L1446L|SMARCA2_ENST00000349721.2_Silent_p.L1464L			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	1464	Bromo.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		ACCGGAGCCTAGGCGACCTGG	0.433000													78	16					0	0	1	0	0
FCGR1A	2209	broad.mit.edu	37	1	149762969	149762969	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:149762969C>T	ENST00000369168.4	+	6	1075	c.1021C>T	c.(1021-1023)Ctt>Ttt	p.L341F	RP11-196G18.3_ENST00000428289.1_RNA|RP11-196G18.21_ENST00000420462.1_RNA|HIST2H2BF_ENST00000545683.1_Intron	NM_000566.3	NP_000557.1	P12314	FCGR1_HUMAN	Fc fragment of IgG, high affinity Ia, receptor (CD64)	341					interferon-gamma-mediated signaling pathway|phagocytosis, engulfment	integral to membrane|plasma membrane	IgG binding|receptor activity|receptor signaling protein activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)	10	Breast(34;0.0124)|all_hematologic(923;0.127)				Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Methyl aminolevulinate(DB00992)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Porfimer(DB00707)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	AATTTCCAGCCTTCAAGAAGA	0.443000													32	44					0	0	1	0	0
SETD3	84193	broad.mit.edu	37	14	99927678	99927678	+	Splice_Site	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr14:99927678C>T	ENST00000331768.5	-	4	356		c.e4-1		SETD3_ENST00000436070.2_Splice_Site|SETD3_ENST00000329331.3_Splice_Site|SETD3_ENST00000453938.1_Intron	NM_032233.2	NP_115609.2	Q86TU7	SETD3_HUMAN	SET domain containing 3						peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|peptidyl-lysine trimethylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone methyltransferase activity (H3-K36 specific)|transcription coactivator activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(8)|ovary(1)|skin(1)	25		all_cancers(154;0.224)|all_epithelial(191;0.0644)|Melanoma(154;0.0866)				ACGGACAGACCTATATTAATC	0.373000													55	59					0	0	1	0	0
ATP5F1	515	broad.mit.edu	37	1	111996918	111996918	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:111996918C>T	ENST00000369722.3	+	3	769	c.163C>T	c.(163-165)Cgt>Tgt	p.R55C	ATP5F1_ENST00000483994.1_Intron|ATP5F1_ENST00000369721.4_Intron	NM_001688.4	NP_001679.2	P24539	AT5F1_HUMAN	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1	55					ATP catabolic process|respiratory electron transport chain	mitochondrial matrix|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transporting ATP synthase activity, rotational mechanism|protein binding	p.R55C(1)		breast(1)|cervix(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	8		all_cancers(81;8.16e-06)|all_epithelial(167;5.63e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		AGGAAAAGTTCGTTATGGACT	0.438000													67	97					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73849751	73849751	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr8:73849751G>A	ENST00000523207.1	+	3	2749	c.2161G>A	c.(2161-2163)Gaa>Aaa	p.E721K		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	721					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			GAACTTTAAGGAAAATAGAGG	0.527000													114	143					0	0	1	0	0
MEGF11	84465	broad.mit.edu	37	15	66416254	66416254	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr15:66416254G>A	ENST00000395625.2	-	3	323	c.59C>T	c.(58-60)tCa>tTa	p.S20L	MEGF11_ENST00000395614.1_5'UTR|MEGF11_ENST00000360698.4_Silent_p.F61F|MEGF11_ENST00000409699.2_Silent_p.F61F|MEGF11_ENST00000422354.1_Silent_p.F61F|MEGF11_ENST00000288745.3_Missense_Mutation_p.S20L			A6BM72	MEG11_HUMAN	multiple EGF-like-domains 11	0						basolateral plasma membrane|integral to membrane				breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	19						TGGTGCACTTGAACCAGTTGA	0.532000													31	42					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56388469	56388469	+	Missense_Mutation	SNP	A	A	C			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:56388469A>C	ENST00000301295.6	+	8	3055	c.2633A>C	c.(2632-2634)gAt>gCt	p.D878A	NLRP4_ENST00000587891.1_Missense_Mutation_p.D803A|NLRP4_ENST00000346986.5_Missense_Mutation_p.D822A	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	878							ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GAAATCGGAGATGTGGGTGTG	0.488000													67	115					0	0	1	0	0
SETD3	84193	broad.mit.edu	37	14	99932055	99932055	+	Missense_Mutation	SNP	T	T	C			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr14:99932055T>C	ENST00000331768.5	-	2	247	c.88A>G	c.(88-90)Agt>Ggt	p.S30G	SETD3_ENST00000436070.2_Missense_Mutation_p.S30G|SETD3_ENST00000329331.3_Missense_Mutation_p.S30G|SETD3_ENST00000453938.1_5'UTR	NM_032233.2	NP_115609.2	Q86TU7	SETD3_HUMAN	SET domain containing 3	30					peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|peptidyl-lysine trimethylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone methyltransferase activity (H3-K36 specific)|transcription coactivator activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(8)|ovary(1)|skin(1)	25		all_cancers(154;0.224)|all_epithelial(191;0.0644)|Melanoma(154;0.0866)				AGCAGCTCACTGGTCAGGTTC	0.493000													29	41					0	0	1	0	0
B3GALT1	8708	broad.mit.edu	37	2	168726366	168726366	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:168726366C>T	ENST00000305861.1	+	2	1168	c.817C>T	c.(817-819)Cga>Tga	p.R273*	AC016723.4_ENST00000430546.1_RNA|B3GALT1_ENST00000392690.2_Nonsense_Mutation_p.R273*|AC016723.4_ENST00000436982.2_RNA	NM_020981.3	NP_066191.1	Q9Y5Z6	B3GT1_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1	273					lipid glycosylation|protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(9)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	18						ACTGTGTCTTCGAAAGCTGGG	0.463000													55	49					0	0	1	0	0
CTSC	1075	broad.mit.edu	37	11	88068216	88068216	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr11:88068216C>T	ENST00000524463.1	-	2	295	c.207G>A	c.(205-207)caG>caA	p.Q69Q	CTSC_ENST00000227266.5_Silent_p.Q69Q|CTSC_ENST00000393301.4_5'UTR|CTSC_ENST00000529974.1_Silent_p.Q69Q	NM_001114173.1|NM_148170.3	NP_001107645.1|NP_680475.1	P53634	CATC_HUMAN	cathepsin C	69			Missing (in PLS).		immune response	lysosome	cysteine-type endopeptidase activity			large_intestine(7)|lung(8)|ovary(2)|prostate(3)|skin(2)	22		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TATCCAGCTTCTGAAGGTACA	0.363000													62	10					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48655877	48655877	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr17:48655877C>T	ENST00000352832.5	+	9	2625	c.2253C>T	c.(2251-2253)atC>atT	p.I751I	CACNA1G_ENST00000502264.1_Silent_p.I751I|CACNA1G_ENST00000514181.1_Silent_p.I751I|CACNA1G_ENST00000359106.5_Silent_p.I751I|CACNA1G_ENST00000515765.1_Silent_p.I751I|CACNA1G_ENST00000512389.1_Silent_p.I751I|CACNA1G_ENST00000515411.1_Silent_p.I751I|CACNA1G_ENST00000515165.1_Silent_p.I751I|CACNA1G_ENST00000510366.1_Silent_p.I751I|CACNA1G_ENST00000507510.2_Silent_p.I751I|CACNA1G_ENST00000514717.1_Silent_p.I751I|CACNA1G_ENST00000510115.1_Silent_p.I751I|CACNA1G_ENST00000513689.2_Silent_p.I751I|CACNA1G_ENST00000503485.1_Silent_p.I751I|CACNA1G_ENST00000513964.1_Silent_p.I751I|CACNA1G_ENST00000507609.1_Silent_p.I751I|CACNA1G_ENST00000514079.1_Silent_p.I751I|CACNA1G_ENST00000507336.1_Silent_p.I751I|CACNA1G_ENST00000429973.2_Silent_p.I751I|CACNA1G_ENST00000358244.5_Silent_p.I751I|CACNA1G_ENST00000442258.2_Silent_p.I751I|CACNA1G_ENST00000354983.4_Silent_p.I751I|CACNA1G_ENST00000416767.4_Silent_p.I751I|CACNA1G_ENST00000505165.1_Silent_p.I751I|CACNA1G_ENST00000507896.1_Silent_p.I751I|CACNA1G_ENST00000360761.4_Silent_p.I751I	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	751					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GAATCATGATCGCCATCCTGG	0.577000													37	63					0	0	1	0	0
PCDHGA7	56108	broad.mit.edu	37	5	140762830	140762830	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:140762830G>A	ENST00000518325.1	+	1	364	c.364G>A	c.(364-366)Gaa>Aaa	p.E122K	PCDHGB3_ENST00000576222.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_018920.2	NP_061743.1														NS(1)|biliary_tract(1)|endometrium(8)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|skin(1)|stomach(3)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TATAGACGTGGAAATAATAGA	0.403000													74	71					0	0	1	0	0
ANKRD17	26057	broad.mit.edu	37	4	73956716	73956716	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr4:73956716C>T	ENST00000358602.4	-	29	6745	c.6629G>A	c.(6628-6630)aGa>aAa	p.R2210K	ANKRD17_ENST00000330838.6_Missense_Mutation_p.R1959K|ANKRD17_ENST00000509867.2_Missense_Mutation_p.R2097K	NM_032217.3	NP_115593.3	O75179	ANR17_HUMAN	ankyrin repeat domain 17	2210					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding	p.R2210T(1)		NS(3)|breast(2)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(39)|ovary(6)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)	96	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			ACTGTGAGGTCTTTTAATGTG	0.458000													75	111					0	0	1	0	0
ITIH1	3697	broad.mit.edu	37	3	52817260	52817260	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr3:52817260G>A	ENST00000273283.2	+	10	1154	c.1130G>A	c.(1129-1131)gGa>gAa	p.G377E	ITIH1_ENST00000537050.1_Missense_Mutation_p.G89E|ITIH1_ENST00000542827.1_Missense_Mutation_p.G377E|ITIH1_ENST00000540715.1_Missense_Mutation_p.G235E	NM_002215.3	NP_002206.2	P19827	ITIH1_HUMAN	inter-alpha-trypsin inhibitor heavy chain 1	377	VWFA.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(16)|lung(18)|ovary(4)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	52				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		TTGCTCCGGGGAATTGAGATC	0.507000													50	7					0	0	1	0	0
MAN2A1	4124	broad.mit.edu	37	5	109065199	109065199	+	Missense_Mutation	SNP	A	A	G			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:109065199A>G	ENST00000261483.4	+	4	1744	c.692A>G	c.(691-693)aAg>aGg	p.K231R		NM_002372.2	NP_002363.2	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	231					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		ATTCAGAAGAAGGATGCTGTT	0.313000													41	91					0	0	1	0	0
C2orf62	375307	broad.mit.edu	37	2	219222261	219222261	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:219222261G>A	ENST00000289388.3	+	3	152	c.123G>A	c.(121-123)aaG>aaA	p.K41K	AC021016.8_ENST00000411433.1_RNA	NM_198559.1	NP_940961.1	Q7Z7H3	CB062_HUMAN	chromosome 2 open reading frame 62	41										endometrium(4)|kidney(2)|large_intestine(4)|lung(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	16		Renal(207;0.0915)		Epithelial(149;8.08e-07)|all cancers(144;0.000146)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCCCAGACAAGGAGGAGCTAC	0.602000													19	21					0	0	1	0	0
OR5T3	390154	broad.mit.edu	37	11	56020522	56020522	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr11:56020522G>A	ENST00000303059.3	+	1	847	c.847G>A	c.(847-849)Gga>Aga	p.G283R		NM_001004747.1	NP_001004747.1	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T, member 3	283					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(23)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	39	Esophageal squamous(21;0.00448)					AATTTATCATGGAACAATTCT	0.398000													49	97					0	0	1	0	0
ST8SIA4	7903	broad.mit.edu	37	5	100231379	100231379	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:100231379G>A	ENST00000231461.5	-	2	534	c.224C>T	c.(223-225)tCc>tTc	p.S75F	ST8SIA4_ENST00000451528.2_Missense_Mutation_p.S75F	NM_005668.4	NP_005659.1	Q92187	SIA8D_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	75					axon guidance|N-glycan processing	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)	25		all_cancers(142;1.5e-07)|all_epithelial(76;1.43e-10)|Prostate(80;0.000644)|Lung NSC(167;0.0059)|all_lung(232;0.00914)|Ovarian(225;0.024)|Colorectal(57;0.09)|Breast(839;0.203)		COAD - Colon adenocarcinoma(37;0.00402)		GACCAAAGAGGAATTGATTTT	0.378000													40	55					0	0	1	0	0
FSIP2	401024	broad.mit.edu	37	2	186673435	186673435	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:186673435G>A	ENST00000343098.5	+	17	19669	c.19669G>A	c.(19669-19671)Gat>Aat	p.D6557N	FSIP2_ENST00000424728.1_Missense_Mutation_p.D6468N	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						TTTTCCATTAGATACAATTAA	0.308000													34	42					0	0	1	0	0
TRIM56	81844	broad.mit.edu	37	7	100732093	100732093	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr7:100732093G>A	ENST00000306085.6	+	3	1797	c.1500G>A	c.(1498-1500)cgG>cgA	p.R500R		NM_030961.1	NP_112223.1	Q9BRZ2	TRI56_HUMAN	tripartite motif containing 56	500					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Lung NSC(181;0.136)|all_lung(186;0.182)					TCCCCACGCGGATGCCTGGAG	0.647000													91	144					0	0	1	0	0
IL1RL1	9173	broad.mit.edu	37	2	102956661	102956661	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:102956661G>A	ENST00000311734.2	+	4	715	c.376G>A	c.(376-378)Gaa>Aaa	p.E126K	IL1RL1_ENST00000409584.1_Missense_Mutation_p.E126K|IL1RL1_ENST00000233954.1_Missense_Mutation_p.E126K|IL1RL1_ENST00000404917.2_Missense_Mutation_p.E9K|IL1RL1_ENST00000393393.3_Missense_Mutation_p.E126K			Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1	126	Ig-like C2-type 2.				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(3)|urinary_tract(1)	16						ATCTGGATCAGAAAAAAATTC	0.343000													24	35					0	0	1	0	0
LRRC1	55227	broad.mit.edu	37	6	53761687	53761687	+	Silent	SNP	T	T	C			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr6:53761687T>C	ENST00000370888.1	+	6	841	c.564T>C	c.(562-564)aaT>aaC	p.N188N		NM_018214.4	NP_060684.4	Q9BTT6	LRRC1_HUMAN	leucine rich repeat containing 1	188						cytoplasm|membrane				cervix(1)|endometrium(3)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20	Lung NSC(77;0.0147)			BRCA - Breast invasive adenocarcinoma(397;0.0745)		AAATATATAATTTGGTAAGTC	0.308000													42	37					0	0	1	0	0
LGI2	55203	broad.mit.edu	37	4	25005729	25005729	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr4:25005729C>T	ENST00000382114.4	-	8	1167	c.982G>A	c.(982-984)Gac>Aac	p.D328N		NM_018176.3	NP_060646.2	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	328						extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(2)	33		Breast(46;0.173)				AGCTCGATGTCATTGGGCTTG	0.458000													93	109					0	0	1	0	0
AIM2	9447	broad.mit.edu	37	1	159038358	159038358	+	Splice_Site	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:159038358C>T	ENST00000368130.4	-	3	684	c.396_splice	c.e3+1	p.K132_splice	AIM2_ENST00000481829.1_5'UTR	NM_004833.1	NP_004824.1	O14862	AIM2_HUMAN	absent in melanoma 2	132					cellular response to drug|immune response|interleukin-1 beta secretion	mitochondrion|nucleus				breast(1)|large_intestine(1)|lung(7)|ovary(2)|pancreas(2)|prostate(2)|skin(1)	16	all_hematologic(112;0.0429)					CTTATCCTACCTTAACATGAG	0.453000													34	47					0	0	1	0	0
ESAM	90952	broad.mit.edu	37	11	124623816	124623816	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr11:124623816C>T	ENST00000278927.5	-	7	1028	c.899G>A	c.(898-900)aGc>aAc	p.S300N	ESAM_ENST00000442070.2_Intron	NM_138961.2	NP_620411.2	Q96AP7	ESAM_HUMAN	endothelial cell adhesion molecule	300					blood coagulation|leukocyte migration	adherens junction|integral to membrane|tight junction				endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.022)		TGTGTCTGAGCTCTTGGGCCA	0.597000													36	2					0	0	1	0	0
CSRP2	1466	broad.mit.edu	37	12	77257053	77257053	+	Missense_Mutation	SNP	A	A	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:77257053A>T	ENST00000311083.5	-	3	307	c.184T>A	c.(184-186)Tac>Aac	p.Y62N	CSRP2_ENST00000547435.1_Missense_Mutation_p.Y62N|CSRP2_ENST00000546966.1_Missense_Mutation_p.Y62N|CSRP2_ENST00000552330.1_Missense_Mutation_p.Y62N	NM_001321.1	NP_001312.1	Q16527	CSRP2_HUMAN	cysteine and glycine-rich protein 2	62					multicellular organismal development	nucleus	zinc ion binding			kidney(1)|large_intestine(4)|ovary(1)|prostate(1)|skin(1)	8						TTCTTTCCGTAGCAGGATTTG	0.493000													38	36					0	0	1	0	0
GPC3	2719	broad.mit.edu	37	X	132833921	132833921	+	Splice_Site	SNP	A	A	C			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chrX:132833921A>C	ENST00000370818.3	-	4	1612		c.e4+1		GPC3_ENST00000543339.1_Splice_Site|GPC3_ENST00000394299.2_Splice_Site	NM_001164618.1|NM_004484.3	NP_001158090.1|NP_004475.1	P51654	GPC3_HUMAN	glypican 3							extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|prostate(1)|skin(2)	36	Acute lymphoblastic leukemia(192;0.000127)					GAAACCTCTCACCTTCTTCGG	0.299000			"""T, D, Mis, N, F, S"""			Wilms tumour			Simpson-Golabi-Behmel syndrome				24	6					0	0	1	0	0
NPC1	4864	broad.mit.edu	37	18	21141474	21141474	+	Missense_Mutation	SNP	G	G	A	rs141243713	byFrequency	TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr18:21141474G>A	ENST00000269228.5	-	5	1035	c.481C>T	c.(481-483)Cgg>Tgg	p.R161W	NPC1_ENST00000540608.1_5'UTR	NM_000271.4	NP_000262.2	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1	161					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(10)|lung(13)|ovary(2)|stomach(1)	38	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					TCCACATCCCGGCAGGCATTG	0.493000													95	82					0	0	1	0	0
ZEB2	9839	broad.mit.edu	37	2	145147408	145147408	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:145147408C>T	ENST00000558170.2	-	10	4439	c.3255G>A	c.(3253-3255)gcG>gcA	p.A1085A	ZEB2_ENST00000539609.3_Silent_p.A1061A|ZEB2_ENST00000409487.3_Silent_p.A1085A|ZEB2_ENST00000303660.4_Silent_p.A1085A	NM_014795.3	NP_055610.1	O60315	ZEB2_HUMAN	zinc finger E-box binding homeobox 2	1085	Glu-rich (acidic).					cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(6)|large_intestine(23)|lung(45)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	107				BRCA - Breast invasive adenocarcinoma(221;0.112)		CCCGCTCCTCCGCCTCCCGCT	0.592000													70	63					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23862667	23862667	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr14:23862667C>T	ENST00000405093.3	-	23	3059	c.2989G>A	c.(2989-2991)Gag>Aag	p.E997K	MYH6_ENST00000356287.3_Missense_Mutation_p.E997K	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	997					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		GCTTTCTTCTCCTTGGTCAGC	0.512000													102	16					0	0	1	0	0
CRYBB1	1414	broad.mit.edu	37	22	27003979	27003979	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr22:27003979G>A	ENST00000215939.2	-	4	436	c.306C>T	c.(304-306)gtC>gtT	p.V102V		NM_001887.3	NP_001878.1	P53674	CRBB1_HUMAN	crystallin, beta B1	102	Beta/gamma crystallin 'Greek key' 2.				visual perception		structural constituent of eye lens			breast(1)|endometrium(4)|large_intestine(8)|lung(8)|ovary(1)|prostate(3)|skin(2)|urinary_tract(4)	31						GCTCAAAGGCGACCCAGCTGG	0.572000													23	61					0	0	1	0	0
E2F8	79733	broad.mit.edu	37	11	19259605	19259605	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr11:19259605G>A	ENST00000527884.1	-	3	322	c.90C>T	c.(88-90)atC>atT	p.I30I	E2F8_ENST00000250024.4_Silent_p.I30I|RP11-428C19.4_ENST00000527978.1_RNA	NM_001256371.1|NM_001256372.1	NP_001243300.1|NP_001243301.1	A0AVK6	E2F8_HUMAN	E2F transcription factor 8	30					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CTGCCAACACGATATTTGCTG	0.453000													36	70					0	0	1	0	0
WNT3	7473	broad.mit.edu	37	17	44845874	44845874	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr17:44845874C>T	ENST00000225512.5	-	4	1042	c.880G>A	c.(880-882)Ggc>Agc	p.G294S		NM_030753.4	NP_110380.1	P56703	WNT3_HUMAN	wingless-type MMTV integration site family, member 3	294					canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|cellular response to retinoic acid|dorsal/ventral axis specification|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic pattern specification|head morphogenesis|hemopoietic stem cell proliferation|inner ear morphogenesis|limb bud formation|mammary gland epithelium development|mesoderm formation|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|positive regulation of cell proliferation|Spemann organizer formation at the anterior end of the primitive streak|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane fraction|membrane raft|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|signal transducer activity			endometrium(2)|large_intestine(6)|lung(4)|prostate(1)	13			BRCA - Breast invasive adenocarcinoma(9;0.0257)			TCCCTTGTGCCAAAGGAACCC	0.602000													69	118					0	0	1	0	0
ZEB2	9839	broad.mit.edu	37	2	145147407	145147407	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:145147407C>T	ENST00000558170.2	-	10	4440	c.3256G>A	c.(3256-3258)Gag>Aag	p.E1086K	ZEB2_ENST00000539609.3_Missense_Mutation_p.E1062K|ZEB2_ENST00000409487.3_Missense_Mutation_p.E1086K|ZEB2_ENST00000303660.4_Missense_Mutation_p.E1086K	NM_014795.3	NP_055610.1	O60315	ZEB2_HUMAN	zinc finger E-box binding homeobox 2	1086	Glu-rich (acidic).					cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(6)|large_intestine(23)|lung(45)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	107				BRCA - Breast invasive adenocarcinoma(221;0.112)		TCCCGCTCCTCCGCCTCCCGC	0.592000													72	62					0	0	1	0	0
BTN3A1	11119	broad.mit.edu	37	6	26413772	26413772	+	Missense_Mutation	SNP	A	A	G			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr6:26413772A>G	ENST00000289361.6	+	10	1762	c.1394A>G	c.(1393-1395)gAc>gGc	p.D465G	BTN3A1_ENST00000414912.2_Missense_Mutation_p.D413G	NM_001145008.1|NM_001145009.1|NM_007048.5	NP_001138480.1|NP_001138481.1|NP_008979.3	O00481	BT3A1_HUMAN	butyrophilin, subfamily 3, member A1	465	B30.2/SPRY.				lipid metabolic process	integral to membrane				breast(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28						GTCTTCCTGGACTATGAGACT	0.468000													88	95					0	0	1	0	0
PCDHB15	56121	broad.mit.edu	37	5	140625626	140625626	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:140625626G>A	ENST00000231173.3	+	1	480	c.480G>A	c.(478-480)ttG>ttA	p.L160L		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		160	Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTCGGGACTTGGACGTGGGCA	0.463000													61	50					0	0	1	0	0
C11orf35	256329	broad.mit.edu	37	11	556900	556900	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr11:556900C>T	ENST00000329451.3	-	8	973	c.911G>A	c.(910-912)cGg>cAg	p.R304Q		NM_173573.2	NP_775844.2	Q8IXW0	CK035_HUMAN	chromosome 11 open reading frame 35	304										NS(1)|breast(1)|central_nervous_system(1)|lung(4)|pancreas(1)	8		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCGGTGGTCCCGGGGCGGGTG	0.687000													5	9					0	0	1	0	0
B4GALNT4	338707	broad.mit.edu	37	11	380153	380153	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr11:380153G>A	ENST00000329962.6	+	17	2666	c.2666G>A	c.(2665-2667)gGg>gAg	p.G889E		NM_178537.4	NP_848632.2	Q76KP1	B4GN4_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 4	889						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			endometrium(2)|kidney(4)|large_intestine(1)|liver(2)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	24		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGACGAACCGGGAACTTCGAG	0.692000													14	25					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43433643	43433643	+	RNA	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:43433643C>T	ENST00000406070.2	-	0	756				PSG7_ENST00000446844.3_RNA	NM_002783.2	NP_002774.2	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				TCACTGGGTTCCGTATTTCAC	0.502000													284	273					0	0	1	0	0
C2orf76	130355	broad.mit.edu	37	2	120078774	120078774	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:120078774G>A	ENST00000409466.2	-	4	661	c.140C>T	c.(139-141)cCt>cTt	p.P47L	C2orf76_ENST00000409877.1_Missense_Mutation_p.P47L|C2orf76_ENST00000334816.7_Missense_Mutation_p.P47L|C2orf76_ENST00000409523.1_Missense_Mutation_p.P47L			Q3KRA6	CB076_HUMAN	chromosome 2 open reading frame 76	47										large_intestine(1)|lung(3)|pancreas(1)	5						GGTCCTTAAAGGGATATCTAC	0.279000													37	33					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82582113	82582113	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr7:82582113C>T	ENST00000423517.2	-	5	8493	c.8156G>A	c.(8155-8157)gGa>gAa	p.G2719E	PCLO_ENST00000333891.8_Missense_Mutation_p.G2719E	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	2650					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TTGCAATTTTCCATCTTCTTT	0.373000													21	39					0	0	1	0	0
CHRNE	1145	broad.mit.edu	37	17	4802086	4802086	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr17:4802086C>T	ENST00000293780.4	-	12	1437	c.1427G>A	c.(1426-1428)gGg>gAg	p.G476E		NM_000080.3	NP_000071.1	Q04844	ACHE_HUMAN	cholinergic receptor, nicotinic, epsilon (muscle)	476					muscle contraction|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(5)|lung(3)|prostate(1)	12						GAAGTAGGCCCCGAGGAAGAT	0.582000													11	11					0	0	1	0	0
ELMOD1	55531	broad.mit.edu	37	11	107521068	107521068	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr11:107521068G>A	ENST00000265840.7	+	8	827	c.562G>A	c.(562-564)Gcg>Acg	p.A188T	ELMOD1_ENST00000531234.1_Missense_Mutation_p.A182T|ELMOD1_ENST00000443271.2_Missense_Mutation_p.A188T	NM_018712.3	NP_061182.3	Q8N336	ELMD1_HUMAN	ELMO/CED-12 domain containing 1	188	ELMO.				phagocytosis	cytoskeleton	GTPase activator activity			endometrium(2)|large_intestine(5)|liver(2)|lung(7)|pancreas(2)|prostate(1)	19		Melanoma(852;0.000288)|Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00301)|all_epithelial(67;0.00304)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Epithelial(105;0.00027)|all cancers(92;0.00481)		CAGGTATTTCGCGGAAAGGGA	0.423000													7	0					0	0	1	0	0
SNRNP200	23020	broad.mit.edu	37	2	96944310	96944310	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:96944310G>A	ENST00000323853.5	-	38	5540	c.5463C>T	c.(5461-5463)taC>taT	p.Y1821Y	SNRNP200_ENST00000349783.5_Intron	NM_014014.4	NP_054733.2	O75643	U520_HUMAN	small nuclear ribonucleoprotein 200kDa (U5)	1821	SEC63 2.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|lung(37)|ovary(7)|prostate(4)|skin(5)|stomach(1)|urinary_tract(1)	90						TGATGTAATAGTAGGCGGCGA	0.587000													34	94					0	0	1	0	0
MACC1	346389	broad.mit.edu	37	7	20198549	20198549	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr7:20198549C>T	ENST00000400331.5	-	5	1743	c.1435G>A	c.(1435-1437)Gag>Aag	p.E479K	MACC1_ENST00000332878.4_Missense_Mutation_p.E479K|MACC1_ENST00000589011.1_Missense_Mutation_p.E479K	NM_182762.3	NP_877439.3	Q6ZN28	MACC1_HUMAN	metastasis associated in colon cancer 1	479					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			endometrium(1)|kidney(1)|large_intestine(15)|lung(12)|ovary(2)|prostate(1)|skin(3)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(1)	39						AAGTGCATCTCTCTGTGCTCA	0.388000													65	64					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3239874	3239874	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chrX:3239874C>T	ENST00000217939.6	-	5	4006	c.3852G>A	c.(3850-3852)ctG>ctA	p.L1284L		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1284						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CCTCAGTTTTCAGAGAAACAG	0.403000													79	17					0	0	1	0	0
POU6F2	11281	broad.mit.edu	37	7	39379403	39379403	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr7:39379403C>T	ENST00000518318.2	+	5	716	c.674C>T	c.(673-675)cCc>cTc	p.P225L	POU6F2_ENST00000559001.1_Missense_Mutation_p.P217L|POU6F2_ENST00000403058.1_Missense_Mutation_p.P225L|POU6F2_ENST00000517348.1_3'UTR			P78424	PO6F2_HUMAN	POU class 6 homeobox 2	225	Gln-rich.|Pro-rich.				central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42						cccaccccaccccagcagcca	0.701000													6	12					0	0	1	0	0
ACTA2	59	broad.mit.edu	37	10	90707056	90707056	+	Missense_Mutation	SNP	T	T	C			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr10:90707056T>C	ENST00000458208.1	-	3	691	c.217A>G	c.(217-219)Ata>Gta	p.I73V	ACTA2_ENST00000224784.6_Missense_Mutation_p.I73V|STAMBPL1_ENST00000371927.3_Intron|ACTA2_ENST00000480297.1_5'UTR	NM_001141945.1	NP_001135417.1	P62736	ACTA_HUMAN	actin, alpha 2, smooth muscle, aorta	73					response to virus	cytosol	ATP binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|skin(1)|urinary_tract(2)	17		Colorectal(252;0.0161)		Colorectal(12;0.000123)|COAD - Colon adenocarcinoma(12;0.00018)		CCATGTTCTATCGGGTACTTC	0.502000													91	18					0	0	1	0	0
CYP4B1	1580	broad.mit.edu	37	1	47276533	47276533	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:47276533G>A	ENST00000271153.4	+	2	270	c.234G>A	c.(232-234)ccG>ccA	p.P78P	CYP4B1_ENST00000371919.4_Silent_p.P78P|CYP4B1_ENST00000371923.4_Silent_p.P78P			P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B, polypeptide 1	78					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	36	Acute lymphoblastic leukemia(166;0.155)					ACCAGTTCCCGTATGCCCACC	0.552000													36	38					0	0	1	0	0
DCST1	149095	broad.mit.edu	37	1	155018676	155018676	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:155018676G>A	ENST00000295542.1	+	12	1444	c.1348G>A	c.(1348-1350)Gcc>Acc	p.A450T	DCST1_ENST00000423025.2_Missense_Mutation_p.A425T|DCST1_ENST00000368419.2_Missense_Mutation_p.A450T|DCST1_ENST00000392480.1_Missense_Mutation_p.A450T	NM_152494.3	NP_689707.2	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1	450						integral to membrane	zinc ion binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	27	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			CACCATCCAGGCCTCAGAAAT	0.552000													46	76					0	0	1	0	0
UBQLN3	50613	broad.mit.edu	37	11	5529744	5529744	+	Silent	SNP	A	A	G			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr11:5529744A>G	ENST00000311659.4	-	2	1192	c.1045T>C	c.(1045-1047)Tta>Cta	p.L349L	HBG2_ENST00000380259.2_Intron	NM_017481.2	NP_059509.1	Q9H347	UBQL3_HUMAN	ubiquilin 3	349										NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|prostate(1)|skin(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTCTCGTGTAATTGCTGGAGA	0.498000													50	67					0	0	1	0	0
B4GALNT4	338707	broad.mit.edu	37	11	373058	373058	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr11:373058C>T	ENST00000329962.6	+	5	477	c.477C>T	c.(475-477)tcC>tcT	p.S159S		NM_178537.4	NP_848632.2	Q76KP1	B4GN4_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 4	159						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			endometrium(2)|kidney(4)|large_intestine(1)|liver(2)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	24		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGGCCGTGTCCCCCAAGTGGA	0.672000													56	48					0	0	1	0	0
PPP1R13B	23368	broad.mit.edu	37	14	104206492	104206492	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr14:104206492G>A	ENST00000202556.9	-	12	2543	c.2261C>T	c.(2260-2262)aCc>aTc	p.T754I	PPP1R13B_ENST00000555391.1_5'UTR|PPP1R13B_ENST00000423488.2_Missense_Mutation_p.T173I	NM_015316.2	NP_056131.2	Q96KQ4	ASPP1_HUMAN	protein phosphatase 1, regulatory subunit 13B	754	Pro-rich.				apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			endometrium(6)|kidney(2)|large_intestine(7)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				ATCGGCCAAGGTGCCCATGAA	0.632000													73	86					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14819311	14819311	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr9:14819311C>T	ENST00000380881.4	-	15	3285	c.2470G>A	c.(2470-2472)Gga>Aga	p.G824R	FREM1_ENST00000422223.2_Missense_Mutation_p.G823R|FREM1_ENST00000380880.3_Missense_Mutation_p.G823R			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	823					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		TCCACCCTTCCGTGCAGAGGC	0.458000													26	5					0	0	1	0	0
GIGYF2	26058	broad.mit.edu	37	2	233715079	233715079	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:233715079G>A	ENST00000373566.3	+	29	4055	c.3858G>A	c.(3856-3858)aaG>aaA	p.K1286K	GIGYF2_ENST00000409547.1_Silent_p.K1264K|GIGYF2_ENST00000409480.1_Silent_p.K1286K|GIGYF2_ENST00000409451.3_Silent_p.K1285K|GIGYF2_ENST00000409196.3_Silent_p.K1258K|GIGYF2_ENST00000373563.4_Silent_p.K1264K			Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2	1264					cell death		protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(17)|lung(11)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	63		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		GCAAGAAGAAGAAAAAGCAGA	0.468000													45	35					0	0	1	0	0
TRBV6-9	28598	broad.mit.edu	37	7	142104519	142104519	+	RNA	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr7:142104519G>A	ENST00000390379.1	-	0	34																											CCACAGGAGAGAAAAGGCCAC	0.597000													49	112					0	0	1	0	0
PHKG1	5260	broad.mit.edu	37	7	56155395	56155395	+	Missense_Mutation	SNP	A	A	G			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr7:56155395A>G	ENST00000452681.2	-	3	307	c.158T>C	c.(157-159)gTc>gCc	p.V53A	PHKG1_ENST00000537360.1_Silent_p.R17R|PHKG1_ENST00000297373.2_Missense_Mutation_p.V53A|PHKG1_ENST00000489604.1_5'UTR	NM_001258459.1	NP_001245388.1	Q16816	PHKG1_HUMAN	phosphorylase kinase, gamma 1 (muscle)	53	Protein kinase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	ATP binding|calmodulin binding|phosphorylase kinase activity			endometrium(1)|large_intestine(1)|lung(5)	7	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TCCACCGGTGACGTCGATGAC	0.642000													31	60					0	0	1	0	0
BIRC8	112401	broad.mit.edu	37	19	53793269	53793269	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:53793269C>T	ENST00000426466.1	-	1	1606	c.359G>A	c.(358-360)cGa>cAa	p.R120Q		NM_033341.4	NP_203127.3	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat containing 8	120					apoptosis		zinc ion binding	p.R120Q(1)		NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(10)|urinary_tract(1)	19				GBM - Glioblastoma multiforme(134;0.00304)		AAATCCCATTCGTATAGCTTC	0.383000													73	128					0	0	1	0	0
VSTM1	284415	broad.mit.edu	37	19	54561718	54561718	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:54561718G>A	ENST00000338372.2	-	3	372	c.197C>T	c.(196-198)tCt>tTt	p.S66F	VSTM1_ENST00000425006.2_Missense_Mutation_p.S66F|VSTM1_ENST00000376626.1_Missense_Mutation_p.S66F|VSTM1_ENST00000366170.2_Intron	NM_198481.3	NP_940883.2	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	66	Ig-like V-type.					integral to membrane				breast(1)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		CTTGTACCCAGAGTCGTTCAC	0.542000													91	90					0	0	1	0	0
LTBR	4055	broad.mit.edu	37	12	6499337	6499337	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:6499337C>T	ENST00000228918.4	+	9	1187	c.861C>T	c.(859-861)ttC>ttT	p.F287F	LTBR_ENST00000539925.1_Silent_p.F268F|LTBR_ENST00000541102.1_Silent_p.F144F	NM_002342.1	NP_002333.1	P36941	TNR3_HUMAN	lymphotoxin beta receptor (TNFR superfamily, member 3)	287					apoptosis|cellular response to mechanical stimulus|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	protein binding|receptor activity			breast(1)|cervix(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)	15						ATCCATACTTCCCTGACTTGG	0.587000													74	123					0	0	1	0	0
RBM42	79171	broad.mit.edu	37	19	36124043	36124043	+	Silent	SNP	C	C	T	rs149753042		TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:36124043C>T	ENST00000262633.4	+	6	678	c.573C>T	c.(571-573)gcC>gcT	p.A191A	RBM42_ENST00000586618.1_Intron|RBM42_ENST00000589871.1_Silent_p.A169A|RBM42_ENST00000589559.1_Silent_p.A162A|RBM42_ENST00000588161.1_Silent_p.A161A|RBM42_ENST00000592202.1_Silent_p.A137A|RBM42_ENST00000360475.4_Silent_p.A162A	NM_024321.3	NP_077297.2	Q9BTD8	RBM42_HUMAN	RNA binding motif protein 42	191	Pro-rich.					cytoplasm|nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(3)|large_intestine(7)|lung(9)|prostate(1)	21	all_lung(56;1.58e-07)|Lung NSC(56;2.43e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CTCACCAGGCCCTCGTGGGCC	0.706000													120	141					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103120167	103120167	+	Splice_Site	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:103120167G>A	ENST00000295269.4	+	3	1437		c.e3+1			NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4						regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity	p.?(1)		NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						GCATCCTGGCGTGAGTACAAA	0.433000													53	49					0	0	1	0	0
TEKT2	27285	broad.mit.edu	37	1	36553376	36553376	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:36553376C>T	ENST00000207457.3	+	9	1174	c.1047C>T	c.(1045-1047)atC>atT	p.I349I		NM_014466.2	NP_055281.2	Q9UIF3	TEKT2_HUMAN	tektin 2 (testicular)	349					cell projection organization|microtubule cytoskeleton organization	actin cytoskeleton|cilium axoneme|flagellar axoneme|focal adhesion|microtubule|nucleolus				breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(2)|pancreas(1)|skin(2)	13		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				AGGCAACCATCGCTGCCCTGA	0.612000													13	31					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	54005089	54005089	+	Splice_Site	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr15:54005089C>T	ENST00000396328.1	-	7	831		c.e7-1		WDR72_ENST00000557913.1_Splice_Site|WDR72_ENST00000559418.1_Splice_Site|WDR72_ENST00000360509.5_Splice_Site	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72											NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		CTTGCTTTTCCTTCAAAAGGA	0.383000													12	25					0	0	1	0	0
KIAA1211	57482	broad.mit.edu	37	4	57182478	57182478	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr4:57182478C>T	ENST00000504228.1	+	6	2915	c.2810C>T	c.(2809-2811)cCa>cTa	p.P937L	KIAA1211_ENST00000264229.6_Missense_Mutation_p.P937L|KIAA1211_ENST00000541073.1_Missense_Mutation_p.P930L			Q6ZU35	K1211_HUMAN	KIAA1211	937	Pro-rich.									endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					CCTGGGCCTCCACCGGCCAGC	0.657000													27	29					0	0	1	0	0
LONP1	9361	broad.mit.edu	37	19	5713200	5713200	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:5713200G>A	ENST00000360614.3	-	3	740	c.583C>T	c.(583-585)Cat>Tat	p.H195Y	LONP1_ENST00000540670.2_5'UTR|LONP1_ENST00000593119.1_Missense_Mutation_p.H131Y|LONP1_ENST00000590729.1_Missense_Mutation_p.H81Y|LONP1_ENST00000585374.1_Missense_Mutation_p.H81Y	NM_004793.2	NP_004784.2	P36776	LONM_HUMAN	lon peptidase 1, mitochondrial	195	Lon.				cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TGCATCTCATGGATCTGGGCA	0.577000													37	72					0	0	1	0	0
LRRC42	115353	broad.mit.edu	37	1	54417686	54417686	+	Missense_Mutation	SNP	T	T	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:54417686T>A	ENST00000371370.3	+	3	535	c.14T>A	c.(13-15)cTc>cAc	p.L5H	LRRC42_ENST00000319223.4_Missense_Mutation_p.L5H	NM_001256409.1	NP_001243338.1	Q9Y546	LRC42_HUMAN	leucine rich repeat containing 42	5										breast(2)|kidney(1)|large_intestine(1)|lung(5)	9						TCTTACTACCTCAGCTCAGAA	0.478000													24	27					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7640184	7640184	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:7640184G>A	ENST00000359156.4	-	8	2023	c.1821C>T	c.(1819-1821)ctC>ctT	p.L607L	CD163_ENST00000541972.1_Silent_p.L595L|CD163_ENST00000432237.2_Silent_p.L607L|CD163_ENST00000396620.3_Silent_p.L640L	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	607	SRCR 6.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						GAGAGTTACAGAGGGATCCCC	0.522000													79	66					0	0	1	0	0
DGKE	8526	broad.mit.edu	37	17	54925412	54925412	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr17:54925412G>A	ENST00000284061.3	+	5	1054	c.874G>A	c.(874-876)Gac>Aac	p.D292N		NM_003647.2	NP_003638.1	P52429	DGKE_HUMAN	diacylglycerol kinase, epsilon 64kDa	292	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|phospholipid biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding|protein binding			breast(3)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	25	Breast(9;3.59e-07)					TGCAGTTGATGACATGAAGAT	0.373000													44	30					0	0	1	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52003316	52003316	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:52003316G>A	ENST00000291707.3	-	2	721	c.666C>T	c.(664-666)ctC>ctT	p.L222L	SIGLEC12_ENST00000598614.1_Silent_p.L104L	NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	222	Ig-like V-type 2.				cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		GGTCCCCAAGGAGGAGGAATC	0.547000													61	133					0	0	1	0	0
ZNF229	7772	broad.mit.edu	37	19	44933724	44933724	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:44933724C>T	ENST00000291187.4	-	6	1536	c.1214G>A	c.(1213-1215)gGg>gAg	p.G405E	ZNF229_ENST00000591289.1_Intron|CTC-512J12.4_ENST00000588655.1_RNA|ZNF229_ENST00000588931.1_Missense_Mutation_p.G411E	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	411					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				GAAGCCCTTCCCACACTCGCT	0.527000													54	50					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16918577	16918577	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:16918577C>T	ENST00000524140.2	+	18	4335	c.3917C>T	c.(3916-3918)tCc>tTc	p.S1306F	NWD1_ENST00000552788.1_Missense_Mutation_p.S1306F|NWD1_ENST00000549814.1_Missense_Mutation_p.S1264F|NWD1_ENST00000379808.3_Missense_Mutation_p.S1306F|NWD1_ENST00000523826.1_Missense_Mutation_p.S1100F|NWD1_ENST00000339803.6_Missense_Mutation_p.S1171F	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1306							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						AACTGCATGTCCCTGAGCAAG	0.627000													43	87					0	0	1	0	0
NCOR1P1	149934	broad.mit.edu	37	20	26084080	26084080	+	RNA	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr20:26084080G>A	ENST00000478176.1	-	0	377					NR_003678.1																						cttctgtagggagaaaaacat	0.299000													6	21					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29055904	29055904	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr18:29055904G>A	ENST00000257189.4	+	16	2764	c.2681G>A	c.(2680-2682)gGa>gAa	p.G894E		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	894					cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding	p.G894E(1)		breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CAGCAGACAGGATTTGTTAAG	0.512000													42	45					0	0	1	0	0
NRK	203447	broad.mit.edu	37	X	105150455	105150455	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chrX:105150455C>T	ENST00000428173.2	+	11	1197	c.894C>T	c.(892-894)ttC>ttT	p.F298F	NRK_ENST00000243300.9_Silent_p.F298F			Q7Z2Y5	NRK_HUMAN	Nik related kinase	298	Protein kinase.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						TAAAAAATTTCCTGTTTCGTC	0.373000										HNSCC(51;0.14)			11	2					0	0	1	0	0
ZNF470	388566	broad.mit.edu	37	19	57088911	57088911	+	Missense_Mutation	SNP	G	G	C			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:57088911G>C	ENST00000330619.8	+	6	1800	c.1114G>C	c.(1114-1116)Gac>Cac	p.D372H	ZNF470_ENST00000601902.1_Intron|ZNF470_ENST00000391709.3_Missense_Mutation_p.D372H	NM_001001668.3	NP_001001668.3	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	372					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(7)|large_intestine(12)|lung(11)|ovary(1)|pancreas(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	41		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		TGAATGTATTGACTGTGGGAA	0.423000													35	34					0	0	1	0	0
FGF14	2259	broad.mit.edu	37	13	102379153	102379153	+	Missense_Mutation	SNP	A	A	C			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr13:102379153A>C	ENST00000376131.4	-	4	526	c.431T>G	c.(430-432)tTt>tGt	p.F144C	FGF14_ENST00000376143.4_Missense_Mutation_p.F139C	NM_175929.2	NP_787125.1	Q92915	FGF14_HUMAN	fibroblast growth factor 14	139					cell death|cell-cell signaling|JNK cascade|nervous system development|signal transduction	nucleus	growth factor activity|heparin binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)	29	all_neural(89;0.0239)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TTCAGGGGTAAAAAGTTCCTG	0.363000													19	26					0	0	1	0	0
VRK3	51231	broad.mit.edu	37	19	50496144	50496144	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:50496144G>A	ENST00000599538.1	-	10	1600	c.936C>T	c.(934-936)atC>atT	p.I312I	VRK3_ENST00000316763.3_Silent_p.I312I|VRK3_ENST00000594092.1_Silent_p.I312I|VRK3_ENST00000601341.1_Silent_p.I262I|VRK3_ENST00000424804.2_5'UTR|VRK3_ENST00000443401.2_Silent_p.I81I|VRK3_ENST00000377011.2_Silent_p.I262I|VRK3_ENST00000593919.1_Silent_p.I312I|VRK3_ENST00000594948.1_Silent_p.I312I|VRK3_ENST00000601912.1_Silent_p.I262I			Q8IV63	VRK3_HUMAN	vaccinia related kinase 3	312	Protein kinase.					nucleus	ATP binding|protein kinase activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|skin(2)|stomach(2)|urinary_tract(1)	23		all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00166)|OV - Ovarian serous cystadenocarcinoma(262;0.00652)		GATCCACAAAGATATTTTCAG	0.493000													82	151					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30316861	30316861	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr10:30316861C>T	ENST00000375377.1	-	3	2317	c.2216G>A	c.(2215-2217)gGt>gAt	p.G739D		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	739										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						TTTGTGATCACCGGTAGGGAA	0.572000													28	11					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				62	65					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179603057	179603057	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:179603057G>A	ENST00000589042.1	-	49	14347	c.14123C>T	c.(14122-14124)cCc>cTc	p.P4708L	TTN_ENST00000359218.5_Missense_Mutation_p.P4470L|TTN_ENST00000342992.6_Missense_Mutation_p.P3464L|TTN_ENST00000591111.1_Missense_Mutation_p.P4391L|TTN_ENST00000342175.6_Missense_Mutation_p.P4537L|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.P4345L|TTN-AS1_ENST00000582847.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4391	Ig-like 27.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACTTCCAGGGGTTCGATTTT	0.458000													7	22					0	0	1	0	0
FBXO17	115290	broad.mit.edu	37	19	39433258	39433258	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:39433258C>T	ENST00000292852.4	-	6	1168	c.827G>A	c.(826-828)cGt>cAt	p.R276H	SARS2_ENST00000448145.2_Intron|FBXO17_ENST00000595329.1_Missense_Mutation_p.R276H|CTC-360G5.8_ENST00000599996.1_Intron	NM_024907.5	NP_079183.4			F-box protein 17											breast(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)	7	all_cancers(60;8.37e-07)|all_lung(34;3.71e-07)|Lung NSC(34;4.17e-07)|all_epithelial(25;1.13e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			CTAGGACAGACGGATCCTGAC	0.577000													5	112					0	0	1	0	0
GAS2L2	246176	broad.mit.edu	37	17	34072985	34072985	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr17:34072985G>A	ENST00000254466.6	-	6	1558	c.1531C>T	c.(1531-1533)Cgc>Tgc	p.R511C	GAS2L2_ENST00000587565.1_Missense_Mutation_p.R495C	NM_139285.3	NP_644814.1	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	511					cell cycle arrest	cytoplasm|cytoskeleton		p.R511C(1)		central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GTTGGGGGGCGAGCAGGGGGC	0.607000													33	84					0	0	1	0	0
KCNA6	3742	broad.mit.edu	37	12	4919741	4919741	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:4919741C>T	ENST00000433855.1	+	1	1400	c.534C>T	c.(532-534)atC>atT	p.I178I	KCNA6_ENST00000280684.3_Silent_p.I178I	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	178						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						GCATCGCCATCGTCTCCGTGT	0.592000										HNSCC(72;0.22)			32	45					0	0	1	0	0
DACH1	1602	broad.mit.edu	37	13	72049847	72049847	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr13:72049847C>T	ENST00000305425.4	-	9	2433	c.2011G>A	c.(2011-2013)Gtc>Atc	p.V671I	DACH1_ENST00000313174.7_Missense_Mutation_p.V523I|DACH1_ENST00000359684.2_Missense_Mutation_p.V723I|DACH1_ENST00000354591.4_Missense_Mutation_p.V469I	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)	721	DACHbox-C.|Interaction with SIN3A (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		CCATTTAAGACCCTGAGACTA	0.388000													116	176					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141722237	141722237	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr7:141722237G>A	ENST00000475668.2	+	7	934	c.880G>A	c.(880-882)Gga>Aga	p.G294R	MGAM_ENST00000549489.2_Missense_Mutation_p.G294R			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	294	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	AACTCCCAATGGAGTAAGCTT	0.433000													44	77					0	0	1	0	0
HERC2P2	400322	broad.mit.edu	37	15	23300080	23300080	+	RNA	SNP	T	T	C	rs28482434	by1000genomes	TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr15:23300080T>C	ENST00000560464.1	-	0	4207																											TGCTGCACGTTGACAGGCGTG	0.612000													4	34					0	0	1	0	0
CNOT6	57472	broad.mit.edu	37	5	179998424	179998424	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:179998424G>A	ENST00000393356.1	+	13	1877	c.1453G>A	c.(1453-1455)Gat>Aat	p.D485N	CNOT6_ENST00000261951.4_Missense_Mutation_p.D485N			Q9ULM6	CNOT6_HUMAN	CCR4-NOT transcription complex, subunit 6	485					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	exonuclease activity|metal ion binding|protein binding|RNA binding			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(10)|skin(1)	23	all_cancers(89;3.3e-05)|all_epithelial(37;7.38e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00543)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.023)		TTACACATTTGATTTCAAGGT	0.413000													33	28					0	0	1	0	0
PDLIM2	64236	broad.mit.edu	37	8	22442859	22442859	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr8:22442859G>A	ENST00000265810.4	+	5	602	c.487G>A	c.(487-489)Ggc>Agc	p.G163S	PDLIM2_ENST00000308354.7_Missense_Mutation_p.G413S|PDLIM2_ENST00000409141.1_Missense_Mutation_p.G163S|PDLIM2_ENST00000448520.1_3'UTR|PDLIM2_ENST00000397761.2_Missense_Mutation_p.G163S|PDLIM2_ENST00000409417.1_Missense_Mutation_p.G163S|PDLIM2_ENST00000397760.4_Missense_Mutation_p.G163S|PDLIM2_ENST00000339162.7_Missense_Mutation_p.G163S	NM_176871.3	NP_789847.1	Q96JY6	PDLI2_HUMAN	PDZ and LIM domain 2 (mystique)	163						actin cytoskeleton|cell surface|cytoplasm|focal adhesion|nucleus	zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|urinary_tract(1)	9		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00579)|Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0626)		ATGTTCCCCGGGCCTCCCCGC	0.682000													16	19					0	0	1	0	0
TGIF2LX	90316	broad.mit.edu	37	X	89177324	89177324	+	Missense_Mutation	SNP	A	A	C			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chrX:89177324A>C	ENST00000561129.2	+	1	370	c.240A>C	c.(238-240)gaA>gaC	p.E80D	TGIF2LX_ENST00000283891.5_Missense_Mutation_p.E80D			Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	80						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(29)|ovary(1)|skin(3)|urinary_tract(1)	40						ACCCTTCAGAAGAAGAGAAGC	0.473000													5	121					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	56044618	56044618	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr6:56044618C>T	ENST00000244728.5	-	3	795	c.398G>A	c.(397-399)cGa>cAa	p.R133Q	COL21A1_ENST00000535941.1_Missense_Mutation_p.R133Q|COL21A1_ENST00000370819.1_Missense_Mutation_p.R133Q	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	133	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity	p.R133Q(2)		breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			AGTCAGAAATCGTGAGGACTT	0.448000													23	27					0	0	1	0	0
TCN1	6947	broad.mit.edu	37	11	59630082	59630082	+	Missense_Mutation	SNP	T	T	C			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr11:59630082T>C	ENST00000257264.3	-	3	477	c.373A>G	c.(373-375)Aaa>Gaa	p.K125E	TCN1_ENST00000532419.1_5'UTR	NM_001062.3	NP_001053.2	P20061	TCO1_HUMAN	transcobalamin I (vitamin B12 binding protein, R binder family)	125					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(15)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GCTTGGAATTTATTTTCTAGC	0.368000													46	65					0	0	1	0	0
NREP	9315	broad.mit.edu	37	5	111066729	111066729	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:111066729G>A	ENST00000379671.3	-	5	360	c.96C>T	c.(94-96)gtC>gtT	p.V32V	NREP_ENST00000446294.2_Silent_p.V32V|NREP_ENST00000509979.1_3'UTR|NREP_ENST00000447165.2_Silent_p.V32V|NREP_ENST00000509025.1_Intron|NREP_ENST00000395634.3_Silent_p.V76V|STARD4-AS1_ENST00000500779.2_RNA|NREP_ENST00000257435.7_Silent_p.V32V|STARD4-AS1_ENST00000513221.1_RNA|NREP_ENST00000453526.2_Silent_p.V32V|NREP_ENST00000515855.1_3'UTR|NREP_ENST00000419114.2_Silent_p.V32V|NREP_ENST00000509427.1_Silent_p.V32V|NREP_ENST00000508870.1_Silent_p.V32V|NREP_ENST00000455559.2_Silent_p.V32V|NREP_ENST00000507742.1_5'UTR|NREP_ENST00000450761.2_Silent_p.V32V	NM_001142478.1	NP_001135950.1	Q16612	NP311_HUMAN	neuronal regeneration related protein	32						cytoplasm											CTTCCTTTGGGACAGGAAGTC	0.473000													29	32					0	0	1	0	0
WBP11	51729	broad.mit.edu	37	12	14940156	14940156	+	Missense_Mutation	SNP	T	T	C			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:14940156T>C	ENST00000261167.2	-	12	2002	c.1769A>G	c.(1768-1770)aAa>aGa	p.K590R	WBP11_ENST00000537574.1_Missense_Mutation_p.K556R	NM_016312.2	NP_057396.1	Q9Y2W2	WBP11_HUMAN	WW domain binding protein 11	590					mRNA processing|RNA splicing|rRNA processing	cytoplasm	single-stranded DNA binding|WW domain binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)	30						AGTAGCCCCTTTATTCTCCCG	0.507000													129	189					0	0	1	0	0
OR7G2	390882	broad.mit.edu	37	19	9213827	9213827	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:9213827G>A	ENST00000305456.2	-	1	155	c.156C>T	c.(154-156)ttC>ttT	p.F52F		NM_001005193.1	NP_001005193.1	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G, member 2	31					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|skin(3)	16						ACATGGACAGGAACAGGCTGA	0.512000													45	81					0	0	1	0	0
BCAM	4059	broad.mit.edu	37	19	45315517	45315517	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:45315517C>T	ENST00000391955.1	+	3	346	c.302C>T	c.(301-303)cCa>cTa	p.P101L	BCAM_ENST00000270233.6_Missense_Mutation_p.P101L			P50895	BCAM_HUMAN	basal cell adhesion molecule (Lutheran blood group)	101	Ig-like V-type 1.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	22	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				CGCAGTCCCCCATACCAGCTG	0.706000													19	28					0	0	1	0	0
FAM170A	340069	broad.mit.edu	37	5	118970109	118970109	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:118970109G>A	ENST00000515256.1	+	3	838	c.666G>A	c.(664-666)gtG>gtA	p.V222V				A1A519	F170A_HUMAN	family with sequence similarity 170, member A	222						intracellular	zinc ion binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	24						ACTGGCTGGTGACCATGGAGA	0.587000													122	145					0	0	1	0	0
ZDHHC8	29801	broad.mit.edu	37	22	20128527	20128527	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr22:20128527C>T	ENST00000334554.7	+	7	1027	c.886C>T	c.(886-888)Cgt>Tgt	p.R296C	ZDHHC8_ENST00000405930.3_Missense_Mutation_p.R296C|ZDHHC8_ENST00000468112.1_3'UTR|ZDHHC8_ENST00000320602.7_Missense_Mutation_p.R204C	NM_013373.3	NP_037505.1	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC-type containing 8	296						cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	20	Colorectal(54;0.0993)					TGGCCTGGGCCGTAGCAAGGT	0.627000													58	80					0	0	1	0	0
SAPCD1	401251	broad.mit.edu	37	6	31730939	31730939	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr6:31730939C>T	ENST00000415669.2	+	1	167	c.108C>T	c.(106-108)ttC>ttT	p.F36F	MSH5-SAPCD1_ENST00000493662.2_3'UTR|SAPCD1_ENST00000425424.1_Silent_p.F36F|MSH5_ENST00000534153.4_3'UTR	NM_001039651.1	NP_001034740.1	Q5SSQ6	G7D_HUMAN	suppressor APC domain containing 1	36																	AGAGCTTCTTCCTTTGGGTGA	0.597000													10	13					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7525992	7525992	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:7525992G>A	ENST00000313599.3	-	14	3711	c.3654C>T	c.(3652-3654)tcC>tcT	p.S1218S	CD163L1_ENST00000416109.2_Silent_p.S1228S|CD163L1_ENST00000396630.1_Silent_p.S1218S			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	1218	SRCR 11.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						ACTGCCATATGGAGATATGCG	0.517000													54	66					0	0	1	0	0
ZNF491	126069	broad.mit.edu	37	19	11917104	11917104	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:11917104C>T	ENST00000323169.5	+	3	667	c.336C>T	c.(334-336)ttC>ttT	p.F112F	ZNF491_ENST00000492230.1_Intron	NM_152356.3	NP_689569.2	Q8N8L2	ZN491_HUMAN	zinc finger protein 491	112					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(14)|lung(6)|ovary(2)|skin(1)	26						AAAAATCTTTCATTTCTCCTG	0.403000													52	59					0	0	1	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24259557	24259557	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr8:24259557G>A	ENST00000538205.1	+	13	1582	c.1035G>A	c.(1033-1035)ggG>ggA	p.G345G	RP11-624C23.1_ENST00000523578.1_RNA|RP11-624C23.1_ENST00000519689.1_RNA|ADAMDEC1_ENST00000256412.4_Silent_p.G424G|ADAMDEC1_ENST00000522298.1_Silent_p.G345G	NM_001145271.1	NP_001138743.1	O15204	ADEC1_HUMAN	ADAM-like, decysin 1	424	Peptidase M12B.				integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|large_intestine(4)|skin(2)|stomach(1)	9		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		CAGTGTGTGGGAACCACCTTC	0.398000													48	62					0	0	1	0	0
LTBR	4055	broad.mit.edu	37	12	6499338	6499338	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:6499338C>T	ENST00000228918.4	+	9	1188	c.862C>T	c.(862-864)Cct>Tct	p.P288S	LTBR_ENST00000539925.1_Missense_Mutation_p.P269S|LTBR_ENST00000541102.1_Missense_Mutation_p.P145S	NM_002342.1	NP_002333.1	P36941	TNR3_HUMAN	lymphotoxin beta receptor (TNFR superfamily, member 3)	288					apoptosis|cellular response to mechanical stimulus|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	protein binding|receptor activity			breast(1)|cervix(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)	15						TCCATACTTCCCTGACTTGGT	0.582000													75	122					0	0	1	0	0
KRTAP5-10	387273	broad.mit.edu	37	11	71277010	71277010	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr11:71277010C>T	ENST00000398531.1	+	1	402	c.377C>T	c.(376-378)tCc>tTc	p.S126F	KRTAP5-10_ENST00000376536.4_Missense_Mutation_p.S78F	NM_001012710.1	NP_001012728.1	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	126	7 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(2)|large_intestine(1)|lung(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	12						GGCTGTGGTTCCTGTGGGGGC	0.657000													215	31					0	0	1	0	0
ATP8B1	5205	broad.mit.edu	37	18	55351389	55351389	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr18:55351389C>T	ENST00000536015.1	-	15	1628	c.1509G>A	c.(1507-1509)ggG>ggA	p.G503G	RP11-35G9.3_ENST00000599199.1_RNA|ATP8B1_ENST00000283684.4_Silent_p.G503G|RP11-35G9.5_ENST00000588925.1_RNA	NM_005603.4	NP_005594.1	O43520	AT8B1_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 1	503					ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(19)|ovary(3)|prostate(1)	53		Colorectal(73;0.229)				ATGCAAGCTTCCCATCAGCAT	0.358000													18	37					0	0	1	0	0
HNF1B	6928	broad.mit.edu	37	17	36093664	36093664	+	Missense_Mutation	SNP	C	C	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr17:36093664C>A	ENST00000225893.4	-	3	1056	c.695G>T	c.(694-696)cGc>cTc	p.R232L	HNF1B_ENST00000427275.2_Missense_Mutation_p.R206L|HNF1B_ENST00000561193.1_Missense_Mutation_p.R206L|HNF1B_ENST00000560016.1_Missense_Mutation_p.R232L	NM_000458.2|NM_001165923.1	NP_000449.1|NP_001159395.1	P35680	HNF1B_HUMAN	HNF1 homeobox B	232					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(6)|kidney(3)|large_intestine(2)|liver(1)|lung(3)|ovary(3)|prostate(1)|skin(2)	28		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			CCGGTTGCGGCGCATCTTCTT	0.567000													58	75					2.27459e-33	2.32888e-33	1	1	0
KHNYN	23351	broad.mit.edu	37	14	24901146	24901146	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr14:24901146C>T	ENST00000251343.5	+	3	818	c.679C>T	c.(679-681)Ccc>Tcc	p.P227S	KHNYN_ENST00000553935.1_Missense_Mutation_p.P227S|KHNYN_ENST00000556842.1_Missense_Mutation_p.P227S			O15037	KHNYN_HUMAN	KH and NYN domain containing	227								p.P227S(1)		kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(3)|pancreas(1)|prostate(3)	24						AGTGAGAGCTCCCCCTAGTGA	0.642000											OREG0022627	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	57	17					0	0	1	0	0
C6orf222	389384	broad.mit.edu	37	6	36294348	36294348	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr6:36294348C>T	ENST00000437635.2	-	5	1152	c.975G>A	c.(973-975)aaG>aaA	p.K325K		NM_001010903.4	NP_001010903.3	P0C671	CF222_HUMAN	chromosome 6 open reading frame 222	325										breast(4)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|skin(4)|urinary_tract(4)	26						AGCTGGACTTCTTGGGTGGCC	0.592000													74	112					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10088273	10088273	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:10088273G>A	ENST00000264828.3	-	42	3208	c.3123C>T	c.(3121-3123)tcC>tcT	p.S1041S		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1041	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			CACTTACCCGGGACCCCTTCT	0.642000													12	19					0	0	1	0	0
OLFM3	118427	broad.mit.edu	37	1	102271725	102271725	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:102271725C>T	ENST00000370103.4	-	5	819	c.606G>A	c.(604-606)ctG>ctA	p.L202L	OLFM3_ENST00000462354.1_5'UTR|OLFM3_ENST00000338858.5_Silent_p.L222L|OLFM3_ENST00000536598.1_3'UTR	NM_058170.2	NP_477518.2	Q96PB7	NOE3_HUMAN	olfactomedin 3	222						extracellular region				breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(24)|ovary(3)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	43		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		TGATTTTCATCAGTTTGCCAC	0.433000													44	64					0	0	1	0	0
IGSF5	150084	broad.mit.edu	37	21	41160105	41160105	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr21:41160105C>T	ENST00000380588.4	+	6	1049	c.946C>T	c.(946-948)Caa>Taa	p.Q316*	IGSF5_ENST00000479378.1_3'UTR	NM_001080444.1	NP_001073913.1	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily, member 5	316						integral to membrane|tight junction				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(7)|skin(2)|stomach(1)	23		Prostate(19;5.35e-06)				ATTTCGTATTCAATTTCAAAA	0.274000													9	18					0	0	1	0	0
FER1L5	90342	broad.mit.edu	37	2	97363878	97363878	+	RNA	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:97363878G>A	ENST00000457909.1	+	0	3844							A0AVI2	FR1L5_HUMAN	fer-1-like 5 (C. elegans)							integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(9)|large_intestine(9)|lung(6)|ovary(2)|prostate(2)|skin(1)|urinary_tract(2)	38						ACAGCCCCGTGGTAGGGGAGT	0.572000													7	6					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10354189	10354189	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr17:10354189C>T	ENST00000255381.2	-	29	3999	c.3889G>A	c.(3889-3891)Gaa>Aaa	p.E1297K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1297					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						GCATCTTTTTCATCTAGCTGT	0.368000													32	70					0	0	1	0	0
ATN1	1822	broad.mit.edu	37	12	7043473	7043473	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:7043473C>T	ENST00000356654.4	+	3	399	c.162C>T	c.(160-162)gcC>gcT	p.A54A	ATN1_ENST00000396684.2_Silent_p.A54A	NM_001007026.1	NP_001007027.1	P54259	ATN1_HUMAN	atrophin 1	54					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	40						GGCAGACAGCCAAGGTATTCT	0.617000													31	52					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108836856	108836856	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr3:108836856G>A	ENST00000232603.5	-	1	133	c.51C>T	c.(49-51)ttC>ttT	p.F17F	MORC1_ENST00000483760.1_Silent_p.F17F	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	17					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						TGGCGTGGATGAAATCCAGAC	0.637000													16	5					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48455158	48455158	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr3:48455158G>A	ENST00000358536.4	-	23	4725	c.4456C>T	c.(4456-4458)Cct>Tct	p.P1486S	PLXNB1_ENST00000456774.1_Missense_Mutation_p.P1303S|PLXNB1_ENST00000448774.2_Missense_Mutation_p.P97S|PLXNB1_ENST00000358459.4_Missense_Mutation_p.P1303S|PLXNB1_ENST00000296440.6_Missense_Mutation_p.P1486S	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	1486					axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GCTGCCACAGGAAAAGCCCCA	0.607000													35	9					0	0	1	0	0
ZNF229	7772	broad.mit.edu	37	19	44933589	44933589	+	Missense_Mutation	SNP	G	G	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:44933589G>T	ENST00000291187.4	-	6	1671	c.1349C>A	c.(1348-1350)cCt>cAt	p.P450H	ZNF229_ENST00000591289.1_Intron|CTC-512J12.4_ENST00000588655.1_RNA|ZNF229_ENST00000588931.1_Missense_Mutation_p.P456H	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	456					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				CTTTTCTCCAGGGTGAATGTG	0.577000													43	47					5.34276e-22	5.45724e-22	1	1	0
CSMD3	114788	broad.mit.edu	37	8	113585828	113585828	+	Missense_Mutation	SNP	A	A	G			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr8:113585828A>G	ENST00000297405.5	-	24	4188	c.3944T>C	c.(3943-3945)aTg>aCg	p.M1315T	CSMD3_ENST00000455883.2_Missense_Mutation_p.M1211T|CSMD3_ENST00000352409.3_Missense_Mutation_p.M1315T|CSMD3_ENST00000343508.3_Missense_Mutation_p.M1275T	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1315	CUB 7.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CAGTCCGCGCATAGATGCACC	0.348000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			83	89					0	0	1	0	0
KCND2	3751	broad.mit.edu	37	7	119915286	119915286	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr7:119915286C>T	ENST00000331113.4	+	1	1565	c.600C>T	c.(598-600)atC>atT	p.I200I		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	200					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					TCTCTGTCATCGCGAATGTGG	0.562000													26	71					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119735075	119735075	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:119735075G>A	ENST00000541757.1	+	8	788	c.408G>A	c.(406-408)ggG>ggA	p.G136G	MARCO_ENST00000327097.4_Silent_p.G214G			Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	214					cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						GTGCTCCAGGGAAGCAAGGAG	0.527000													31	61					0	0	1	0	0
KCNA6	3742	broad.mit.edu	37	12	4919910	4919910	+	Missense_Mutation	SNP	C	C	T	rs149897413		TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:4919910C>T	ENST00000433855.1	+	1	1569	c.703C>T	c.(703-705)Cat>Tat	p.H235Y	KCNA6_ENST00000280684.3_Missense_Mutation_p.H235Y	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	235						voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.H235Y(1)		NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						CTACACATTTCATCATGGCAT	0.552000										HNSCC(72;0.22)			67	82					0	0	1	0	0
TP53BP1	7158	broad.mit.edu	37	15	43707815	43707815	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr15:43707815C>T	ENST00000263801.3	-	23	5303	c.5051G>A	c.(5050-5052)cGc>cAc	p.R1684H	TP53BP1_ENST00000450115.2_Missense_Mutation_p.R1689H|TP53BP1_ENST00000382039.3_Missense_Mutation_p.R1639H|TP53BP1_ENST00000382044.4_Missense_Mutation_p.R1689H	NM_005657.2	NP_005648.1	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1	1684					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			breast(4)|endometrium(5)|kidney(7)|large_intestine(22)|lung(13)|ovary(4)|pancreas(2)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(3)	72		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		GGCAGACTTGCGACCTCGCTT	0.498000								Other conserved DNA damage response genes					4	173					0	0	1	0	0
OR2T33	391195	broad.mit.edu	37	1	248436232	248436232	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:248436232C>T	ENST00000318021.2	-	1	906	c.885G>A	c.(883-885)gtG>gtA	p.V295V		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	295					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GGGCTCCCTTCACCTCACTGT	0.468000													107	145					0	0	1	0	0
VENTX	27287	broad.mit.edu	37	10	135053190	135053190	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr10:135053190G>A	ENST00000325980.9	+	2	763	c.252G>A	c.(250-252)aaG>aaA	p.K84K		NM_014468.2	NP_055283.1	O95231	VENTX_HUMAN	VENT homeobox	84					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|large_intestine(1)|lung(9)|soft_tissue(1)|upper_aerodigestive_tract(1)	14		all_cancers(35;4.15e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.8e-06)|Epithelial(32;9.31e-06)|all cancers(32;1.19e-05)		GGTTGAGTAAGGAGCCAAATA	0.607000													19	2					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219892656	219892656	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:219892656C>T	ENST00000341552.5	-	13	2010	c.1927G>A	c.(1927-1929)Gac>Aac	p.D643N	CCDC108_ENST00000410037.1_Missense_Mutation_p.D578N|CCDC108_ENST00000441968.1_Missense_Mutation_p.D643N|CCDC108_ENST00000409865.3_Missense_Mutation_p.D632N|CCDC108_ENST00000453220.1_Missense_Mutation_p.D643N	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	643						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ATGGTTATGTCGCTGGTGCCG	0.612000													65	49					0	0	1	0	0
TOP3B	8940	broad.mit.edu	37	22	22324585	22324585	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr22:22324585G>A	ENST00000398793.2	-	6	1012	c.578C>T	c.(577-579)aCc>aTc	p.T193I	TOP3B_ENST00000357179.5_Missense_Mutation_p.T193I|TOP3B_ENST00000413067.2_Intron	NM_003935.3	NP_003926.1	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	193					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(4)|lung(9)|ovary(1)	26	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		CCAGCACCTGGTGAATGCACA	0.647000													24	30					0	0	1	0	0
SEPHS2	22928	broad.mit.edu	37	16	30456871	30456871	+	Nonstop_Mutation	SNP	A	A	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr16:30456871A>T	ENST00000478753.2	-	1	631	c.178T>A	c.(178-180)Tga>Aga	p.*60R	SEPHS2_ENST00000542752.1_Intron|SEPHS2_ENST00000500504.2_Nonstop_Mutation_p.*60R			Q99611	SPS2_HUMAN	selenophosphate synthetase 2	60					selenocysteine biosynthetic process		ATP binding|selenide, water dikinase activity			breast(3)|cervix(1)|kidney(1)|large_intestine(3)|lung(1)|upper_aerodigestive_tract(1)	10						TTGCAGCCTCAGCCCTTCATG	0.726000													6	6					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40116347	40116347	+	Silent	SNP	G	G	A	rs143570961	byFrequency	TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr20:40116347G>A	ENST00000373233.3	-	14	2136	c.1959C>T	c.(1957-1959)acC>acT	p.T653T	CHD6_ENST00000309279.7_Intron	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	653					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				CCAAGAAAGCGGTCTCTGAAG	0.428000													54	64					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	55929411	55929411	+	Nonsense_Mutation	SNP	C	C	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr6:55929411C>A	ENST00000244728.5	-	24	2534	c.2137G>T	c.(2137-2139)Gga>Tga	p.G713*	COL21A1_ENST00000535941.1_Nonsense_Mutation_p.G713*|COL21A1_ENST00000370819.1_Nonsense_Mutation_p.G710*|COL21A1_ENST00000370808.2_Nonsense_Mutation_p.G113*|COL21A1_ENST00000467045.1_5'UTR	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	713	Collagen-like 4.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			CCATTTTCTCCCTTTTGACCC	0.328000													7	6					2.7689e-08	2.79496e-08	1	1	0
ZNF878	729747	broad.mit.edu	37	19	12155349	12155349	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:12155349C>T	ENST00000602107.1	-	5	1007	c.1008G>A	c.(1006-1008)agG>agA	p.R336R	CTD-2006C1.2_ENST00000591838.1_RNA|CTD-2006C1.2_ENST00000476474.1_RNA|ZNF878_ENST00000547628.1_Silent_p.R289R|CTD-2006C1.10_ENST00000547473.1_Intron|CTD-2006C1.2_ENST00000591898.1_RNA			C9JN71	ZN878_HUMAN	zinc finger protein 878	289					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|lung(4)|urinary_tract(1)	8						TGAAGGCTTTCCTACATTGTG	0.403000													32	55					0	0	1	0	0
SLC30A3	7781	broad.mit.edu	37	2	27481769	27481769	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:27481769C>T	ENST00000233535.4	-	2	481	c.129G>A	c.(127-129)gaG>gaA	p.E43E	SLC30A3_ENST00000447008.2_Silent_p.E38E	NM_003459.4	NP_003450.2	Q99726	ZNT3_HUMAN	solute carrier family 30 (zinc transporter), member 3	43					regulation of sequestering of zinc ion	cell junction|integral to plasma membrane|late endosome|membrane fraction|synaptic vesicle membrane	zinc transporting ATPase activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(11)|pancreas(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTTTGGACTCCTCAGGGAGGG	0.632000													20	26					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179603056	179603056	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:179603056G>A	ENST00000589042.1	-	49	14348	c.14124C>T	c.(14122-14124)ccC>ccT	p.P4708P	TTN_ENST00000359218.5_Silent_p.P4470P|TTN_ENST00000342992.6_Silent_p.P3464P|TTN_ENST00000591111.1_Silent_p.P4391P|TTN_ENST00000342175.6_Silent_p.P4537P|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.P4345P|TTN-AS1_ENST00000582847.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4391	Ig-like 27.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTACTTCCAGGGGTTCGATTT	0.463000													7	21					0	0	1	0	0
PCDH1	5097	broad.mit.edu	37	5	141242917	141242917	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:141242917C>T	ENST00000287008.3	-	3	3126	c.2979G>A	c.(2977-2979)gtG>gtA	p.V993V	PCDH1_ENST00000456271.1_Silent_p.V981V|PCDH1_ENST00000536585.1_Silent_p.V971V|PCDH1_ENST00000511044.1_5'UTR|PCDH1_ENST00000394536.3_Silent_p.V993V|PCDH1_ENST00000503492.1_Intron	NM_032420.2	NP_115796.2	Q08174	PCDH1_HUMAN	protocadherin 1	993					cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(20)|ovary(5)|skin(3)|upper_aerodigestive_tract(1)	51		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		GGTCCTGTACCACCTGGTGCT	0.637000													31	3					0	0	1	0	0
PCSK9	255738	broad.mit.edu	37	1	55527199	55527199	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:55527199G>A	ENST00000302118.5	+	11	2123	c.1833G>A	c.(1831-1833)aaG>aaA	p.K611K	PCSK9_ENST00000490692.1_3'UTR|PCSK9_ENST00000543384.1_3'UTR	NM_174936.3	NP_777596.2	Q8NBP7	PCSK9_HUMAN	proprotein convertase subtilisin/kexin type 9	611					cellular response to insulin stimulus|cellular response to starvation|cholesterol homeostasis|cholesterol metabolic process|kidney development|liver development|low-density lipoprotein particle receptor catabolic process|lysosomal transport|negative regulation of catalytic activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor recycling|neuron differentiation|positive regulation of neuron apoptosis|positive regulation of receptor internalization|protein autoprocessing|regulation of receptor activity	extracellular space|late endosome|lysosome|perinuclear region of cytoplasm	apolipoprotein receptor binding|identical protein binding|low-density lipoprotein particle receptor binding|serine-type endopeptidase activity|very-low-density lipoprotein particle receptor binding			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(1)|liver(2)|lung(4)|ovary(3)|prostate(3)|skin(1)|urinary_tract(1)	32						GCAAAGTCAAGGAGCATGGAA	0.637000													9	12					0	0	1	0	0
IGHV3-43	28426	broad.mit.edu	37	14	106926250	106926250	+	RNA	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr14:106926250G>A	ENST00000434710.1	-	0	371																											TGCAGATACAGGGAGTTTTTG	0.478000													105	201					0	0	1	0	0
ATRX	546	broad.mit.edu	37	X	76938536	76938536	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chrX:76938536G>A	ENST00000373344.5	-	9	2426	c.2212C>T	c.(2212-2214)Ctc>Ttc	p.L738F	ATRX_ENST00000480283.1_5'UTR|ATRX_ENST00000395603.3_Missense_Mutation_p.L700F	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	738					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.I737fs*3(1)|p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	ACCTCTTTGAGGATTGCTAGC	0.353000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						180	34					0	0	1	0	0
CASZ1	54897	broad.mit.edu	37	1	10713615	10713615	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:10713615G>A	ENST00000377022.3	-	11	2816	c.2499C>T	c.(2497-2499)acC>acT	p.T833T	CASZ1_ENST00000344008.5_Silent_p.T833T|RP4-734G22.3_ENST00000606802.1_RNA	NM_001079843.1	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	833					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		GTGTGTCAGGGGTGGCTGAGG	0.692000													30	31					0	0	1	0	0
MPI	4351	broad.mit.edu	37	15	75189870	75189870	+	Nonstop_Mutation	SNP	T	T	C			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr15:75189870T>C	ENST00000566377.1	+	7	897	c.862T>C	c.(862-864)Tga>Cga	p.*288R	MPI_ENST00000535694.1_Silent_p.T307T|MPI_ENST00000323744.6_Silent_p.T296T|MPI_ENST00000563786.1_Silent_p.T337T|MPI_ENST00000352410.4_Silent_p.T357T			P34949	MPI_HUMAN	mannose phosphate isomerase	0					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	mannose-6-phosphate isomerase activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|upper_aerodigestive_tract(1)	9						GCTCTGTCACTGAATACAAGG	0.572000													20	43					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10404651	10404651	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr17:10404651C>T	ENST00000226207.5	-	27	3608	c.3514G>A	c.(3514-3516)Gag>Aag	p.E1172K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1172						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						AACTCAGCCTCCCGCTTCTTG	0.612000													70	156					0	0	1	0	0
GPR64	10149	broad.mit.edu	37	X	19021223	19021223	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chrX:19021223C>T	ENST00000354791.3	-	23	2164	c.1923G>A	c.(1921-1923)cgG>cgA	p.R641R	GPR64_ENST00000379876.1_Silent_p.R633R|GPR64_ENST00000379869.3_Silent_p.R657R|GPR64_ENST00000379873.2_Silent_p.R657R|GPR64_ENST00000379878.3_Silent_p.R641R|GPR64_ENST00000340581.3_Silent_p.R538R|GPR64_ENST00000360279.4_Silent_p.R635R|GPR64_ENST00000357991.3_Silent_p.R654R|GPR64_ENST00000356606.4_Silent_p.R643R|GPR64_ENST00000357544.3_Silent_p.R627R			Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64	657					neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(18)|stomach(1)|urinary_tract(1)	42	Hepatocellular(33;0.183)					GGTAATCCCTCCGGATCTTTC	0.463000													43	11					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89979993	89979993	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:89979993G>A	ENST00000405460.2	+	28	6351	c.6255G>A	c.(6253-6255)gcG>gcA	p.A2085A		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	2085					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTTTAGTAGCGAAAGTACAGA	0.333000													16	14					0	0	1	0	0
ZNF257	113835	broad.mit.edu	37	19	22271817	22271817	+	Missense_Mutation	SNP	A	A	G			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:22271817A>G	ENST00000594947.1	+	4	1409	c.1265A>G	c.(1264-1266)aAg>aGg	p.K422R		NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	422					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.K422T(1)		haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACTCAGCATAAGATAATTCAT	0.373000													4	64					0	0	1	0	0
SFTA3	253970	broad.mit.edu	37	14	36946189	36946189	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr14:36946189G>A	ENST00000518529.2	-	3	923	c.248C>T	c.(247-249)tCa>tTa	p.S83L	RP11-896J10.3_ENST00000521945.1_RNA|SFTA3_ENST00000518987.1_Intron	NM_001101341.1	NP_001094811.1	P0C7M3	SFTA3_HUMAN	surfactant associated 3	83										breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|skin(1)	7						GGCCTCGGATGAACTCCTGCT	0.517000													82	24					0	0	1	0	0
OR6C3	254786	broad.mit.edu	37	12	55725998	55725998	+	Missense_Mutation	SNP	G	G	C			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:55725998G>C	ENST00000379667.1	+	1	514	c.514G>C	c.(514-516)Gat>Cat	p.D172H		NM_054104.1	NP_473445.1	Q9NZP0	OR6C3_HUMAN	olfactory receptor, family 6, subfamily C, member 3	172					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|prostate(1)|skin(2)	11						CAACGTCATTGATCACTTTGC	0.433000													114	133					0	0	1	0	0
ZRANB3	84083	broad.mit.edu	37	2	136111037	136111037	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:136111037C>T	ENST00000401392.1	-	4	554	c.342G>A	c.(340-342)caG>caA	p.Q114Q	ZRANB3_ENST00000264159.6_Silent_p.Q114Q|ZRANB3_ENST00000536680.1_Silent_p.Q114Q			Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	114	Helicase ATP-binding.					intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			NS(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|upper_aerodigestive_tract(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.135)		CAGTTTTATTCTGAATAACAT	0.353000													30	21					0	0	1	0	0
EPHB6	2051	broad.mit.edu	37	7	142566474	142566474	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr7:142566474C>T	ENST00000392957.2	+	15	3050	c.2263C>T	c.(2263-2265)Ccc>Tcc	p.P755S	EPHB6_ENST00000442129.1_Missense_Mutation_p.P755S|EPHB6_ENST00000411471.2_Missense_Mutation_p.P478S	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	755	Protein kinase.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					GGAGCTTGGCCCCCTGGACAG	0.612000													35	57					0	0	1	0	0
LINC01410	103352539	broad.mit.edu	37	9	66459909	66459909	+	RNA	SNP	T	T	C	rs146531631	by1000genomes	TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr9:66459909T>C	ENST00000424345.1	+	0	169																											cattaaaatcttgggcatgca	0.368000													3	23					0	0	1	0	0
CLUL1	27098	broad.mit.edu	37	18	619340	619340	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr18:619340G>A	ENST00000581619.1	+	3	1156	c.309G>A	c.(307-309)aaG>aaA	p.K103K	CLUL1_ENST00000580436.1_3'UTR|CLUL1_ENST00000338387.7_Silent_p.K78K|CLUL1_ENST00000400606.2_Silent_p.K78K|CLUL1_ENST00000540035.1_Silent_p.K130K|CLUL1_ENST00000579494.1_Silent_p.K78K			Q15846	CLUL1_HUMAN	clusterin-like 1 (retinal)	78					cell death	extracellular region				NS(1)|breast(1)|endometrium(5)|large_intestine(5)|liver(2)|lung(7)|ovary(2)|skin(1)	24						GCACCCTGAAGAAATGCAGAG	0.383000													41	46					0	0	1	0	0
MAGEA10	4109	broad.mit.edu	37	X	151303278	151303278	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chrX:151303278G>A	ENST00000370323.4	-	4	1131	c.815C>T	c.(814-816)aCc>aTc	p.T272I	RP11-1007I13.4_ENST00000509345.2_RNA|MAGEA10_ENST00000244096.3_Missense_Mutation_p.T272I	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	272	MAGE.									endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					CCAATCTTGGGTGAGCAGCTT	0.552000													97	21					0	0	1	0	0
TMEM154	201799	broad.mit.edu	37	4	153573855	153573855	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr4:153573855G>A	ENST00000304385.3	-	2	520	c.289C>T	c.(289-291)Ctt>Ttt	p.L97F	TMEM154_ENST00000504064.1_Missense_Mutation_p.L97F	NM_152680.2	NP_689893.1	Q6P9G4	TM154_HUMAN	transmembrane protein 154	97						integral to membrane				kidney(2)|large_intestine(1)	3	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)				TATGTTGCAAGGAATACCACG	0.318000													30	41					0	0	1	0	0
GUCA1C	9626	broad.mit.edu	37	3	108672519	108672519	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr3:108672519G>A	ENST00000261047.3	-	1	223	c.91C>T	c.(91-93)Cca>Tca	p.P31S	GUCA1C_ENST00000393963.3_Missense_Mutation_p.P31S|GUCA1C_ENST00000471108.1_Missense_Mutation_p.P31S	NM_005459.3	NP_005450.3	O95843	GUC1C_HUMAN	guanylate cyclase activator 1C	31	EF-hand 1.				signal transduction|visual perception		calcium ion binding|calcium sensitive guanylate cyclase activator activity			endometrium(2)|large_intestine(1)|liver(1)|lung(8)|pancreas(1)|skin(1)	14						AGGCCGGATGGATATTCCATC	0.403000													71	13					0	0	1	0	0
MIR516B2	574485	broad.mit.edu	37	19	54228765	54228765	+	RNA	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:54228765G>A	ENST00000385190.1	+	0	70					NR_030207.1																						TCCTTTCAGAGGGTTACTCTT	0.403000													23	32					0	0	1	0	0
TTBK1	84630	broad.mit.edu	37	6	43251674	43251674	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr6:43251674G>A	ENST00000259750.4	+	14	3279	c.3196G>A	c.(3196-3198)Ggc>Agc	p.G1066S		NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	1066						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			GGAGGACACGGGCTCGGAGCC	0.667000													33	37					0	0	1	0	0
BCAN	63827	broad.mit.edu	37	1	156626103	156626103	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:156626103G>A	ENST00000329117.4	+	9	2308	c.1972G>A	c.(1972-1974)Ggt>Agt	p.G658S	RP11-284F21.7_ENST00000448869.1_RNA	NM_021948.4	NP_068767.3	Q96GW7	PGCB_HUMAN	brevican	658	EGF-like.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTGCCACAATGGTGGGACATG	0.652000													78	89					0	0	1	0	0
LINC01410	103352539	broad.mit.edu	37	9	66466567	66466567	+	RNA	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr9:66466567C>T	ENST00000424345.1	+	0	1200																											atttagaccacggtataaaaa	0.413000													3	9					0	0	1	0	0
TMEM161B	153396	broad.mit.edu	37	5	87501742	87501742	+	Missense_Mutation	SNP	A	A	G			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:87501742A>G	ENST00000296595.6	-	8	813	c.689T>C	c.(688-690)tTt>tCt	p.F230S	TMEM161B_ENST00000511218.1_Missense_Mutation_p.F48S|TMEM161B_ENST00000506536.1_Missense_Mutation_p.F48S|TMEM161B_ENST00000509387.1_Missense_Mutation_p.F103S|TMEM161B_ENST00000512429.1_Missense_Mutation_p.F219S|TMEM161B_ENST00000514135.1_Missense_Mutation_p.F230S	NM_153354.3	NP_699185.1	Q8NDZ6	T161B_HUMAN	transmembrane protein 161B	230						integral to membrane				endometrium(4)|large_intestine(3)|lung(9)|skin(3)|upper_aerodigestive_tract(1)	20		all_cancers(142;0.000275)|Lung NSC(167;0.00901)|all_lung(232;0.0111)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;6.24e-36)|Epithelial(54;6.8e-31)|all cancers(79;1.07e-26)		AGCCAGGAAAAATTTGAAAGT	0.308000													45	45					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21232573	21232573	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:21232573G>A	ENST00000233242.1	-	26	7294	c.7167C>T	c.(7165-7167)taC>taT	p.Y2389Y		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2389					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATTTCTCAAAGTAATCTTTTA	0.308000													20	32					0	0	1	0	0
HOXD3	3232	broad.mit.edu	37	2	177036457	177036457	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:177036457G>A	ENST00000468418.3	+	4	2844	c.754G>A	c.(754-756)Gac>Aac	p.D252N	HOXD3_ENST00000410016.1_Missense_Mutation_p.D252N|HOXD3_ENST00000249440.3_Missense_Mutation_p.D252N			P31249	HXD3_HUMAN	homeobox D3	252					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(11)|prostate(1)|upper_aerodigestive_tract(2)	23			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		GTACAAGAAGGACCAGAAGGC	0.662000													58	105					0	0	1	0	0
HSH2D	84941	broad.mit.edu	37	19	16268501	16268501	+	Missense_Mutation	SNP	T	T	C			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:16268501T>C	ENST00000253680.6	+	9	1486	c.955T>C	c.(955-957)Tcc>Ccc	p.S319P	HSH2D_ENST00000588246.1_3'UTR|HSH2D_ENST00000397372.4_Missense_Mutation_p.S229P|HSH2D_ENST00000593154.2_3'UTR			Q96JZ2	HSH2D_HUMAN	hematopoietic SH2 domain containing	319						cytoplasm|nucleus				central_nervous_system(1)|kidney(1)|large_intestine(2)	4						AGCCCTATCCTCCCAGGAGTC	0.617000													7	19					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109380511	109380511	+	Silent	SNP	T	T	C			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:109380511T>C	ENST00000283195.6	+	20	3642	c.3516T>C	c.(3514-3516)ttT>ttC	p.F1172F		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	1172	RanBD1 1.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						GTCCTCACTTTGAGCCTGTAG	0.428000													92	87					0	0	1	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14779981	14779981	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr18:14779981C>T	ENST00000358984.4	+	11	1623	c.1443C>T	c.(1441-1443)tcC>tcT	p.S481S	ANKRD30B_ENST00000579292.1_Intron|ANKRD30B_ENST00000447268.2_Silent_p.S481S	NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	481										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						CATCAGAATCCAAACGAGAGG	0.279000													4	33					0	0	1	0	0
IL22RA1	58985	broad.mit.edu	37	1	24447751	24447751	+	Silent	SNP	T	T	C			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:24447751T>C	ENST00000270800.1	-	7	1307	c.1269A>G	c.(1267-1269)aaA>aaG	p.K423K		NM_021258.3	NP_067081.2	Q8N6P7	I22R1_HUMAN	interleukin 22 receptor, alpha 1	423						integral to membrane	interferon receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		GCCTAAGGTGTTTAGGACTAG	0.557000													49	52					0	0	1	0	0
TMEM130	222865	broad.mit.edu	37	7	98460820	98460820	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr7:98460820C>T	ENST00000450876.1	-	2	1352	c.37G>A	c.(37-39)Ggc>Agc	p.G13S	TMEM130_ENST00000339375.4_Missense_Mutation_p.G97S|TMEM130_ENST00000345589.4_Intron|TMEM130_ENST00000546258.1_Missense_Mutation_p.G78S|TMEM130_ENST00000416379.2_Missense_Mutation_p.G97S			Q8N3G9	TM130_HUMAN	transmembrane protein 130	97						Golgi membrane|integral to membrane				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	25	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GGCACGTGGCCGACCACACGG	0.647000													63	47					0	0	1	0	0
C1orf227	149643	broad.mit.edu	37	1	213009290	213009290	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:213009290G>A	ENST00000332912.3	-	2	309	c.202C>T	c.(202-204)Ccc>Tcc	p.P68S		NM_001024601.2	NP_001019772.1	Q537H7	CA227_HUMAN	chromosome 1 open reading frame 227	68										kidney(1)|large_intestine(1)|lung(1)	3						CCACTGTTGGGAACAGGCTCT	0.458000													88	91					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152722325	152722325	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr6:152722325G>A	ENST00000367255.5	-	47	7578	c.6977C>T	c.(6976-6978)tCg>tTg	p.S2326L	SYNE1_ENST00000341594.5_Missense_Mutation_p.S2363L|SYNE1_ENST00000423061.1_Missense_Mutation_p.S2333L|SYNE1_ENST00000448038.1_Missense_Mutation_p.S2333L|SYNE1_ENST00000265368.4_Missense_Mutation_p.S2326L	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2326					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GTTCATCAACGATTCTTCCAC	0.368000										HNSCC(10;0.0054)			55	10					0	0	1	0	0
C1orf177	163747	broad.mit.edu	37	1	55277497	55277497	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:55277497G>A	ENST00000358193.3	+	5	565	c.511G>A	c.(511-513)Gag>Aag	p.E171K	C1orf177_ENST00000371273.3_Missense_Mutation_p.E171K	NM_152607.2	NP_689820.2	Q3ZCV2	CA177_HUMAN	chromosome 1 open reading frame 177	171										breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(6)|prostate(2)	17						AAATTATGGGGAGAAGGGTAA	0.592000													34	39					0	0	1	0	0
EPHX2	2053	broad.mit.edu	37	8	27394339	27394339	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr8:27394339G>A	ENST00000521400.1	+	13	1639	c.1209G>A	c.(1207-1209)cgG>cgA	p.R403R	EPHX2_ENST00000518379.1_Silent_p.R371R|EPHX2_ENST00000517536.1_Silent_p.R220R|EPHX2_ENST00000380476.3_Silent_p.R350R|EPHX2_ENST00000521780.1_Silent_p.R337R	NM_001979.5	NP_001970.2	P34913	HYES_HUMAN	epoxide hydrolase 2, cytoplasmic	403	Epoxide hydrolase.		R -> RR.		aromatic compound catabolic process|cellular calcium ion homeostasis|drug metabolic process|inflammatory response|positive regulation of vasodilation|reactive oxygen species metabolic process|regulation of blood pressure|response to toxin|xenobiotic metabolic process	cytosol|focal adhesion|Golgi apparatus|nucleolus|peroxisome|soluble fraction	epoxide hydrolase activity|metal ion binding|protein homodimerization activity			cervix(1)|endometrium(8)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|skin(5)|stomach(1)|urinary_tract(1)	27		Ovarian(32;2.61e-05)|all_epithelial(46;0.207)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0226)|Epithelial(17;1.12e-09)|Colorectal(74;0.157)	Tamoxifen(DB00675)	ACCTGAGTCGGACTTTCAAAA	0.517000													46	55					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129906958	129906958	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr10:129906958C>T	ENST00000368654.3	-	13	3521	c.3146G>A	c.(3145-3147)gGg>gAg	p.G1049E	MKI67_ENST00000368653.3_Missense_Mutation_p.G689E	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	1049	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CGTGGTCTCCCCTGACGTCCG	0.542000													222	44					0	0	1	0	0
ATP5F1	515	broad.mit.edu	37	1	111996905	111996905	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:111996905C>T	ENST00000369722.3	+	3	756	c.150C>T	c.(148-150)taC>taT	p.Y50Y	ATP5F1_ENST00000483994.1_Intron|ATP5F1_ENST00000369721.4_Intron	NM_001688.4	NP_001679.2	P24539	AT5F1_HUMAN	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1	50					ATP catabolic process|respiratory electron transport chain	mitochondrial matrix|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transporting ATP synthase activity, rotational mechanism|protein binding			breast(1)|cervix(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	8		all_cancers(81;8.16e-06)|all_epithelial(167;5.63e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		TTCCTGAATACGGAGGAAAAG	0.438000													66	85					0	0	1	0	0
MTTP	4547	broad.mit.edu	37	4	100504592	100504592	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr4:100504592G>A	ENST00000457717.1	+	4	567	c.311G>A	c.(310-312)gGa>gAa	p.G104E	MTTP_ENST00000265517.5_Missense_Mutation_p.G104E|MTTP_ENST00000511045.1_Missense_Mutation_p.G131E|MTTP_ENST00000422897.2_Missense_Mutation_p.G104E	NM_000253.2	NP_000244.2	P55157	MTP_HUMAN	microsomal triglyceride transfer protein	104	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(14)|lung(19)|ovary(4)|prostate(5)|skin(1)|urinary_tract(1)	57				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	ATCTTCAAAGGAAAAAGCCCA	0.388000													49	96					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118343093	118343093	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr11:118343093C>T	ENST00000534358.1	+	3	1242	c.1219C>T	c.(1219-1221)Cga>Tga	p.R407*	KMT2A_ENST00000389506.5_Nonsense_Mutation_p.R407*|KMT2A_ENST00000354520.4_Nonsense_Mutation_p.R407*	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		CAAAAATATTCGACAGTTCAT	0.443000													64	80					0	0	1	0	0
NDUFAF5	79133	broad.mit.edu	37	20	13797545	13797545	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr20:13797545C>T	ENST00000378106.5	+	10	1006	c.887C>T	c.(886-888)tCa>tTa	p.S296L	NDUFAF5_ENST00000475968.1_3'UTR|NDUFAF5_ENST00000463598.1_Missense_Mutation_p.S268L	NM_024120.4	NP_077025.2	Q5TEU4	CT007_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 5	296					mitochondrial respiratory chain complex I assembly	extrinsic to mitochondrial inner membrane	methyltransferase activity										GAAGATGGTTCAGTACCTGCT	0.343000													38	49					0	0	1	0	0
PITPNM1	9600	broad.mit.edu	37	11	67267718	67267718	+	Missense_Mutation	SNP	C	C	T	rs140119237		TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr11:67267718C>T	ENST00000356404.3	-	6	1040	c.815G>A	c.(814-816)gGg>gAg	p.G272E	PITPNM1_ENST00000534749.1_Missense_Mutation_p.G272E|PITPNM1_ENST00000436757.2_Missense_Mutation_p.G272E	NM_001130848.1|NM_004910.2	NP_001124320.1|NP_004901.2	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein, membrane-associated 1	272					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(3)	18						GCTCGGTTTCCCGGGGGGCTG	0.697000													96	14					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200971309	200971309	+	Missense_Mutation	SNP	T	T	C			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:200971309T>C	ENST00000332129.2	-	9	1698	c.1382A>G	c.(1381-1383)aAc>aGc	p.N461S	KIF21B_ENST00000360529.5_Missense_Mutation_p.N461S|KIF21B_ENST00000461742.2_Missense_Mutation_p.N461S|KIF21B_ENST00000422435.2_Missense_Mutation_p.N461S	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	461					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						TAGCAGCAGGTTGGCCTCCTG	0.637000													50	70					0	0	1	0	0
CYP2B7P	1556	broad.mit.edu	37	19	41430338	41430338	+	RNA	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:41430338C>T	ENST00000599198.1	+	0	215					NR_001278.1															NS(1)|endometrium(6)|kidney(1)|lung(2)|ovary(1)|skin(1)	12						CTACTCAAATCCTTTCTGAGG	0.567000													90	119					0	0	1	0	0
CPEB4	80315	broad.mit.edu	37	5	173382928	173382928	+	Missense_Mutation	SNP	T	T	C			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:173382928T>C	ENST00000265085.5	+	10	3432	c.1978T>C	c.(1978-1980)Tat>Cat	p.Y660H	CPEB4_ENST00000517880.1_Missense_Mutation_p.Y253H|CPEB4_ENST00000520867.1_Missense_Mutation_p.Y635H|CPEB4_ENST00000334035.5_Missense_Mutation_p.Y643H|CPEB4_ENST00000519467.1_3'UTR|CPEB4_ENST00000522336.1_Missense_Mutation_p.Y270H	NM_030627.2	NP_085130.2	Q17RY0	CPEB4_HUMAN	cytoplasmic polyadenylation element binding protein 4	660	RRM 2.						nucleotide binding|RNA binding			NS(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	20	Renal(175;0.000159)|Lung NSC(126;0.0128)|all_lung(126;0.0202)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			AGTTAAGCCATATGTCTTGGA	0.423000													45	88					0	0	1	0	0
TARDBP	23435	broad.mit.edu	37	1	11076934	11076934	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:11076934C>T	ENST00000240185.3	+	3	386	c.272C>T	c.(271-273)tCa>tTa	p.S91L	TARDBP_ENST00000439080.2_Intron|TARDBP_ENST00000315091.3_Missense_Mutation_p.S91L	NM_007375.3	NP_031401.1	Q13148	TADBP_HUMAN	TAR DNA binding protein	91					3'-UTR-mediated mRNA stabilization|cell death|mRNA processing|negative regulation by host of viral transcription|RNA splicing|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)	11	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0578)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.37e-07)|COAD - Colon adenocarcinoma(227;7.38e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)		ACAGATGCTTCATCAGCAGTG	0.368000													42	52					0	0	1	0	0
PCDHB13	56123	broad.mit.edu	37	5	140595672	140595672	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:140595672C>T	ENST00000341948.4	+	1	2164	c.1977C>T	c.(1975-1977)caC>caT	p.H659H		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		659	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCACGCTGCACGTGCTCCTGG	0.716000													6	181					0	0	1	0	0
ARL10	285598	broad.mit.edu	37	5	175795841	175795841	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:175795841G>A	ENST00000310389.5	+	3	513	c.417G>A	c.(415-417)tgG>tgA	p.W139*		NM_173664.4	NP_775935.1	Q8N8L6	ARL10_HUMAN	ADP-ribosylation factor-like 10	139							GTP binding			endometrium(2)|lung(1)|ovary(1)	4	all_cancers(89;0.0064)|Renal(175;0.000269)|Lung NSC(126;0.0105)|all_lung(126;0.0168)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.0965)		GCTTCTACTGGAAGGAGTTTG	0.672000													69	107					0	0	1	0	0
MID2	11043	broad.mit.edu	37	X	107170294	107170294	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chrX:107170294C>T	ENST00000262843.6	+	10	2747	c.2199C>T	c.(2197-2199)acC>acT	p.T733T	RP6-191P20.4_ENST00000430140.1_RNA|MID2_ENST00000443968.2_Silent_p.T703T	NM_012216.3|NM_052817.2	NP_036348.2|NP_438112.2	Q9UJV3	TRIM1_HUMAN	midline 2	733						centrosome|microtubule	ligase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(7)|ovary(1)|prostate(2)	19						GGATGAAAACCTGTCATTAAG	0.453000													32	13					0	0	1	0	0
TMCO1	54499	broad.mit.edu	37	1	165721392	165721392	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:165721392G>A	ENST00000367881.5	-	5	698	c.423C>T	c.(421-423)tcC>tcT	p.S141S	TMCO1_ENST00000464650.1_Silent_p.S6S|TMCO1_ENST00000392129.6_Silent_p.S90S|TMCO1_ENST00000580248.1_Silent_p.S6S			Q9UM00	TMCO1_HUMAN	transmembrane and coiled-coil domains 1	90						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)	9	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					TAGCAAACATGGATTTCATTC	0.308000													17	26					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10432131	10432131	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr17:10432131G>A	ENST00000245503.5	-	27	4004	c.3620C>T	c.(3619-3621)gCc>gTc	p.A1207V	MYH2_ENST00000397183.2_Missense_Mutation_p.A1207V|MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1207					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						CCCAAGCTCGGCCACACTATC	0.542000													76	102					0	0	1	0	0
DENND1A	57706	broad.mit.edu	37	9	126144500	126144500	+	Silent	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr9:126144500G>A	ENST00000373624.2	-	22	2442	c.2241C>T	c.(2239-2241)gcC>gcT	p.A747A	DENND1A_ENST00000473039.1_5'UTR|DENND1A_ENST00000542603.1_Silent_p.A532A|DENND1A_ENST00000394219.3_Silent_p.A758A	NM_020946.1	NP_065997.1	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A	747	Pro-rich.					cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|liver(2)|lung(18)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43						CTGGACTCAGGGCAGCTCGCC	0.711000													15	5					0	0	1	0	0
TSSK1B	83942	broad.mit.edu	37	5	112769450	112769450	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:112769450C>T	ENST00000390666.3	-	1	1278	c.1087G>A	c.(1087-1089)Gag>Aag	p.E363K	CTD-2201G3.1_ENST00000416046.2_RNA|MCC_ENST00000408903.3_Intron|CTD-2201G3.1_ENST00000383058.4_RNA	NM_032028.3	NP_114417.1	Q9BXA7	TSSK1_HUMAN	testis-specific serine kinase 1B	363					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(8)|ovary(2)|skin(2)|stomach(1)	13		all_cancers(142;0.0138)|all_epithelial(76;0.000445)|Colorectal(10;0.00814)|Prostate(80;0.0115)|Ovarian(225;0.156)		Epithelial(69;4.15e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.49e-08)|all cancers(49;3.2e-06)|COAD - Colon adenocarcinoma(37;0.0371)|Colorectal(14;0.0449)		GCCCGCGTCTCTGGAGGCTGT	0.602000													25	28					0	0	1	0	0
SLITRK5	26050	broad.mit.edu	37	13	88328648	88328648	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr13:88328648C>T	ENST00000325089.6	+	2	1224	c.1005C>T	c.(1003-1005)cgC>cgT	p.R335R	SLITRK5_ENST00000400028.3_Silent_p.R94R	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	335						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					AGGGGACTCGCCAACCCAACA	0.587000													54	114					0	0	1	0	0
CCDC64	92558	broad.mit.edu	37	12	120499606	120499606	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:120499606C>T	ENST00000397558.2	+	3	738	c.738C>T	c.(736-738)atC>atT	p.I246I		NM_207311.2	NP_997194.2	Q6ZP65	BICR1_HUMAN	coiled-coil domain containing 64	246					Golgi to secretory granule transport|neuron projection development	centrosome	dynactin binding|Rab GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(2)|lung(4)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	22	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGCACATTATCCGGCTGGAGA	0.512000													40	17					0	0	1	0	0
SPATA16	83893	broad.mit.edu	37	3	172835147	172835147	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr3:172835147C>T	ENST00000351008.3	-	2	558	c.375G>A	c.(373-375)atG>atA	p.M125I		NM_031955.5	NP_114161.3	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	125					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			breast(2)|cervix(1)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	43	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			AGACCAACTTCATTTCCACAT	0.418000													79	17					0	0	1	0	0
BCL11B	64919	broad.mit.edu	37	14	99641476	99641476	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr14:99641476C>T	ENST00000345514.2	-	3	1750	c.1484G>A	c.(1483-1485)cGc>cAc	p.R495H	BCL11B_ENST00000357195.3_Missense_Mutation_p.R566H|BCL11B_ENST00000443726.2_Missense_Mutation_p.R372H	NM_022898.1	NP_075049.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	566						nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		GCCGTTCTCGCGGTTGCGGCT	0.711000			T	TLX3	T-ALL								12	15					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53855644	53855644	+	Silent	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:53855644C>T	ENST00000458035.1	+	4	1833	c.1716C>T	c.(1714-1716)atC>atT	p.I572I	ZNF845_ENST00000595091.1_Silent_p.I572I	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	572					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						ATCAAGCAATCCATGGTATAG	0.398000													35	40					0	0	1	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57077340	57077340	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr11:57077340C>T	ENST00000532437.1	-	5	3156	c.2845G>A	c.(2845-2847)Gaa>Aaa	p.E949K	TNKS1BP1_ENST00000358252.3_Missense_Mutation_p.E949K|TNKS1BP1_ENST00000530920.1_5'UTR			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	949	Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				AACTCCTGTTCCTGTGGCTCC	0.587000													92	147					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21032478	21032478	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:21032478C>T	ENST00000381545.3	+	11	1463	c.1244C>T	c.(1243-1245)tCg>tTg	p.S415L	SLCO1B7_ENST00000554957.1_Intron|SLCO1B3_ENST00000553473.1_Missense_Mutation_p.S415L|LST3_ENST00000540229.1_Missense_Mutation_p.S415L|SLCO1B3_ENST00000261196.2_Missense_Mutation_p.S415L|LST3_ENST00000381541.3_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	415					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					TTTCTTACTTCGATGATATCC	0.343000													35	33					0	0	1	0	0
TRDV1	28518	broad.mit.edu	37	14	22564892	22564892	+	RNA	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr14:22564892G>A	ENST00000390452.2	+	0	361																											TGCTCTTGGGGAACTCACAGT	0.438000													21	4					0	0	1	0	0
PSG4	5672	broad.mit.edu	37	19	43699349	43699349	+	Missense_Mutation	SNP	A	A	C			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:43699349A>C	ENST00000405312.3	-	4	1023	c.786T>G	c.(784-786)tgT>tgG	p.C262W	PSG4_ENST00000244295.9_Intron|PSG4_ENST00000433626.2_Missense_Mutation_p.C169W	NM_002780.3	NP_002771.2	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4	262	Ig-like C2-type 2.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	24		Prostate(69;0.00682)				TCTTAGGTTCACAGGTGAAGG	0.453000													167	221					0	0	1	0	0
OGFOD3	79701	broad.mit.edu	37	17	80367249	80367249	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr17:80367249C>T	ENST00000313056.5	-	4	569	c.418G>A	c.(418-420)Gga>Aga	p.G140R	OGFOD3_ENST00000329197.5_Missense_Mutation_p.G140R	NM_024648.2|NM_175902.4	NP_078924.1|NP_787098.3			2-oxoglutarate and iron-dependent oxygenase domain containing 3																		CTCACCCCTCCGTCAGATCCT	0.483000													28	35					0	0	1	0	0
NEGR1	257194	broad.mit.edu	37	1	72400930	72400930	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:72400930C>T	ENST00000357731.4	-	2	480	c.241G>A	c.(241-243)Gga>Aga	p.G81R	NEGR1_ENST00000306821.3_5'UTR|NEGR1_ENST00000434200.1_Missense_Mutation_p.G79R|NEGR1_ENST00000467479.1_5'UTR	NM_173808.2	NP_776169.2	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1	81	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane				endometrium(1)|kidney(4)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		TTATCACCTCCCGCAAAAATA	0.403000													43	56					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124411309	124411309	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:124411309G>A	ENST00000409039.3	+	68	11718	c.11693G>A	c.(11692-11694)cGa>cAa	p.R3898Q	DNAH10OS_ENST00000514254.2_3'UTR|CCDC92_ENST00000544798.1_Intron	NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3898	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TTAGCAGAGCGAAGTGGTTTT	0.458000													22	33					0	0	1	0	0
GRIN2D	2906	broad.mit.edu	37	19	48945500	48945500	+	Missense_Mutation	SNP	T	T	C			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:48945500T>C	ENST00000263269.3	+	12	2622	c.2534T>C	c.(2533-2535)aTg>aCg	p.M845T		NM_000836.2	NP_000827.2	O15399	NMDE4_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	845						cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			autonomic_ganglia(1)|breast(6)|endometrium(2)|large_intestine(9)|lung(12)|ovary(5)|pancreas(1)|prostate(1)	37		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	ATCGACAACATGGCGGGCGTC	0.607000													99	157					0	0	1	0	0
ZSWIM2	151112	broad.mit.edu	37	2	187693133	187693133	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:187693133G>A	ENST00000295131.2	-	9	1519	c.1480C>T	c.(1480-1482)Ccc>Tcc	p.P494S		NM_182521.2	NP_872327.2	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM-type containing 2	494					apoptosis		zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(28)|ovary(2)|prostate(4)|skin(6)|urinary_tract(1)	52			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			AGATACCTGGGAAAATGTTGG	0.318000													41	28					0	0	1	0	0
ZFPM1	161882	broad.mit.edu	37	16	88552350	88552350	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr16:88552350C>T	ENST00000319555.3	+	2	366	c.44C>T	c.(43-45)tCc>tTc	p.S15F	ZFPM1_ENST00000569086.1_3'UTR	NM_153813.2	NP_722520.2	Q8IX07	FOG1_HUMAN	zinc finger protein, FOG family member 1	15					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|transcription factor binding|zinc ion binding			central_nervous_system(1)|ovary(2)|urinary_tract(1)	4				BRCA - Breast invasive adenocarcinoma(80;0.0478)		TCCACAGGTTCCCTCGGAGAC	0.662000													37	41					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19747051	19747051	+	Splice_Site	SNP	C	C	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:19747051C>T	ENST00000507958.1	-	6	1513	c.523_splice	c.e6+1	p.G175_splice	CDH18_ENST00000506372.1_Splice_Site_p.G175_splice|CDH18_ENST00000382275.1_Splice_Site_p.G175_splice|CDH18_ENST00000274170.4_Splice_Site_p.G175_splice|CDH18_ENST00000511273.1_Splice_Site_p.G175_splice|CDH18_ENST00000502796.1_Splice_Site_p.G175_splice			Q13634	CAD18_HUMAN	cadherin 18, type 2	175	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TTTTTCTTACCCATATCTGAC	0.308000													32	42					0	0	1	0	0
RP5-884C9.2	0	broad.mit.edu	37	1	38564935	38564936	+	RNA	INS	-	-	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:38564935_38564936insA	ENST00000432922.1	+	0	301																											gactccgtctcaaaaaaaaaaa	0.485													2	4	---	---	---	---					
RP11-417J8.2	0	broad.mit.edu	37	1	142572257	142572258	+	RNA	INS	-	-	G	rs145671478	by1000genomes	TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:142572257_142572258insG	ENST00000415979.2	-	0	215																											TAAACAACTTTTTTTACTGGCA	0.347													2	4	---	---	---	---					
LOC101927209	101927209	broad.mit.edu	37	1	142664224	142664224	+	RNA	DEL	A	A	-			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr1:142664224delA	ENST00000369381.2	-	0	2507				RP11-417J8.3_ENST00000426408.1_lincRNA																							aatttacaagaaaaaaaaacc	0.383													2	4	---	---	---	---					
AC007563.5	0	broad.mit.edu	37	2	217722107	217722107	+	RNA	DEL	G	G	-			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr2:217722107delG	ENST00000447289.1	+	0	510																											AGGGGAAGATGGGGACCAGAG	0.493													2	4	---	---	---	---					
CTD-2325B11.1	0	broad.mit.edu	37	4	125156785	125156785	+	RNA	DEL	G	G	-			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr4:125156785delG	ENST00000507299.1	-	0	53																											gaaatattcagggaaatgatg	0.308													2	4	---	---	---	---					
RP11-427M20.1	0	broad.mit.edu	37	4	134878149	134878149	+	RNA	DEL	G	G	-			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr4:134878149delG	ENST00000507844.1	-	0	223																											tgatttgggtggggacacaat	0.438													2	4	---	---	---	---					
LOC728339	728339	broad.mit.edu	37	4	190818022	190818022	+	RNA	DEL	A	A	-	rs113369235		TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr4:190818022delA	ENST00000511785.1	-	0	231																											ttgtgatggtaggggggtggc	0.413													3	5	---	---	---	---					
LINC01411	101928176	broad.mit.edu	37	5	173805720	173805720	+	RNA	DEL	C	C	-			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr5:173805720delC	ENST00000510234.1	+	0	82																											gggtgccttgccccccaggcc	0.517													3	4	---	---	---	---					
FAM50B	26240	broad.mit.edu	37	6	3850771	3850778	+	Frame_Shift_Del	DEL	CATCCTGC	CATCCTGC	-			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr6:3850771_3850778delCATCCTGC	ENST00000380274.1	+	1	1152_1159	c.726_733delCATCCTGC	c.(724-735)ctcgfs	p.LILP242fs	FAM50B_ENST00000380272.3_Frame_Shift_Del_p.LILP242fs			Q9Y247	FA50B_HUMAN	family with sequence similarity 50, member B	242						nucleus				cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|pancreas(1)|prostate(3)|urinary_tract(3)	17	Ovarian(93;0.0925)	all_hematologic(90;0.108)				AGGAGGACCTCATCCTGCCGCACTACCA	0.625													38	59	---	---	---	---					
HCG23	414764	broad.mit.edu	37	6	32358414	32358415	+	RNA	INS	-	-	A	rs34784784	by1000genomes	TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr6:32358414_32358415insA	ENST00000426643.1	+	0	128_129					NR_044996.1																						ATGTGACTGATAAAACCAATTT	0.366													4	3	---	---	---	---					
FAM66D	100132923	broad.mit.edu	37	8	12002444	12002445	+	RNA	DEL	TG	TG	-			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr8:12002444_12002445delTG	ENST00000434078.2	+	0	608					NR_027425.1																						tgtgtgtgactgtgtgtgtgtg	0.460													3	4	---	---	---	---					
LINC01410	103352539	broad.mit.edu	37	9	66458156	66458157	+	RNA	INS	-	-	G			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr9:66458156_66458157insG	ENST00000424345.1	+	0	67				RNA5SP283_ENST00000365604.1_RNA																							cctacggtaccgctattaccag	0.624													2	4	---	---	---	---					
LINC01410	103352539	broad.mit.edu	37	9	66466800	66466800	+	RNA	DEL	G	G	-	rs139943429	by1000genomes	TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr9:66466800delG	ENST00000424345.1	+	0	1433																											CCTCATCAGAGGACCCCAGAT	0.522													5	10	---	---	---	---					
RP11-764K9.1	0	broad.mit.edu	37	9	68406651	68406652	+	RNA	INS	-	-	AA	rs149817678	by1000genomes	TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr9:68406651_68406652insAA	ENST00000417843.2	-	0	224																											aagagaaaaacaaaaaacccta	0.366													2	4	---	---	---	---					
RP11-445N18.7	0	broad.mit.edu	37	10	45652086	45652087	+	RNA	INS	-	-	A	rs77869897		TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr10:45652086_45652087insA	ENST00000427229.2	+	0	1739																											agactcagtctaaaaaaaaaaa	0.431													5	3	---	---	---	---					
RP11-574M7.1	0	broad.mit.edu	37	11	50274722	50274722	+	RNA	DEL	A	A	-			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr11:50274722delA	ENST00000528459.1	+	0	184																											CCAAGGCTCGAAAACATCTTT	0.368													2	4	---	---	---	---					
ACAT1	38	broad.mit.edu	37	11	108009679	108009689	+	Frame_Shift_Del	DEL	AACAGAGGATC	AACAGAGGATC	-			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr11:108009679_108009689delAACAGAGGATC	ENST00000265838.4	+	6	581_591	c.490_500delAACAGAGGATC	c.(490-501)afs	p.NRGS164fs		NM_000019.3	NP_000010.1	P24752	THIL_HUMAN	acetyl-CoA acetyltransferase 1	164					acetoacetic acid biosynthetic process|branched chain family amino acid catabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	acetyl-CoA C-acetyltransferase activity|metal ion binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(3)|prostate(2)	10		all_cancers(61;6.41e-10)|all_epithelial(67;2.83e-06)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;2.96e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.00108)|OV - Ovarian serous cystadenocarcinoma(223;0.192)	Sulfasalazine(DB00795)	ATATGTAATGAACAGAGGATCAACACCATAT	0.384													59	122	---	---	---	---					
RP3-473L9.4	0	broad.mit.edu	37	12	111815740	111815740	+	RNA	DEL	A	A	-			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr12:111815740delA	ENST00000552663.1	+	0	141																											ctgaggcaggagaatcgtttg	0.512													2	4	---	---	---	---					
MTUS2	23281	broad.mit.edu	37	13	29599994	29599995	+	Frame_Shift_Del	DEL	GG	GG	-			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr13:29599994_29599995delGG	ENST00000431530.3	+	1	1247_1248	c.1189_1190delGG	c.(1189-1191)gfs	p.G397fs		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	387						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						AGTCAACCCAGGGGAGCAGGAT	0.569													15	21	---	---	---	---					
BMS1P18	414763	broad.mit.edu	37	14	19898079	19898080	+	RNA	INS	-	-	T			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr14:19898079_19898080insT	ENST00000552602.1	-	0	202																											cttttcttttcttttttttttt	0.490													4	6	---	---	---	---					
HERC2P3	283755	broad.mit.edu	37	15	20616554	20616555	+	RNA	INS	-	-	A	rs7183995	by1000genomes	TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr15:20616554_20616555insA	ENST00000428453.1	-	0	4041																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						caaaacaaaacaaaaaaaaaac	0.332													2	4	---	---	---	---					
LINC01193	348120	broad.mit.edu	37	15	21148310	21148310	+	RNA	DEL	C	C	-			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr15:21148310delC	ENST00000553416.1	+	0	515					NR_040094.1																						GTACCACAGGCCTCGGTGGAA	0.667													3	4	---	---	---	---					
RP11-184D12.1	0	broad.mit.edu	37	15	36474461	36474462	+	RNA	INS	-	-	A			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr15:36474461_36474462insA	ENST00000561394.1	-	0	136																											CAGGATGTTGGAAAAAAAAAAG	0.386													4	3	---	---	---	---					
STARD9	57519	broad.mit.edu	37	15	42984789	42984789	+	Frame_Shift_Del	DEL	G	G	-			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr15:42984789delG	ENST00000290607.7	+	23	11070	c.11013delG	c.(11011-11013)ctfs	p.L3671fs		NM_020759.2	NP_065810.2			StAR-related lipid transfer (START) domain containing 9											haematopoietic_and_lymphoid_tissue(1)|stomach(1)	2						CCTTTGATCTGGCCTCATGGA	0.582													2	4	---	---	---	---					
MIR7162	102466227	broad.mit.edu	37	15	62538522	62538523	+	RNA	INS	-	-	GA	rs3055695		TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr15:62538522_62538523insGA	ENST00000570077.1	-	0	693_694																											GGGGGCTCCGGGTAGGGGTTCA	0.609													3	4	---	---	---	---					
RP11-165E7.1	0	broad.mit.edu	37	16	5070479	5070479	+	RNA	DEL	C	C	-			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr16:5070479delC	ENST00000588778.1	+	0	365																											CCACACAGATCCTGGGACTCT	0.577													2	4	---	---	---	---					
RP11-10K17.6	0	broad.mit.edu	37	16	5180670	5180670	+	RNA	DEL	G	G	-			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr16:5180670delG	ENST00000589323.1	+	0	345																											AGGGGCAgctgggcacggtgg	0.532													2	4	---	---	---	---					
RP11-252A24.2	0	broad.mit.edu	37	16	74399048	74399048	+	RNA	DEL	A	A	-			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr16:74399048delA	ENST00000429810.2	-	0	176																											tatttttagtagagatggagt	0.537													2	4	---	---	---	---					
RP11-101O21.1	0	broad.mit.edu	37	17	72067506	72067507	+	RNA	INS	-	-	T	rs139865295	by1000genomes	TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr17:72067506_72067507insT	ENST00000584003.1	-	0	515																											AAGGTGGGGAGCAGTGAGGCGT	0.535													5	6	---	---	---	---					
ADGRE4P	326342	broad.mit.edu	37	19	6954925	6954926	+	RNA	INS	-	-	GAT	rs144507846	by1000genomes	TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:6954925_6954926insGAT	ENST00000600751.1	-	0	1817					NR_024075.1																						AGGACTCAATAgatgatgatga	0.342													2	4	---	---	---	---					
CTC-360P9.4	0	broad.mit.edu	37	19	32509673	32509674	+	RNA	DEL	AG	AG	-			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr19:32509673_32509674delAG	ENST00000590053.1	-	0	77																											agagacagacagagagagagag	0.391													2	4	---	---	---	---					
RP5-1164C1.2	0	broad.mit.edu	37	20	4470257	4470257	+	RNA	DEL	G	G	-			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr20:4470257delG	ENST00000419863.1	+	0	41																											ctgtggggctggggctggggc	0.602													2	4	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11050075	11050077	+	RNA	DEL	GTT	GTT	-	rs55661652		TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr21:11050075_11050077delGTT	ENST00000470054.1	-	0	487									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATTAAGAAACGTTAATATCAATT	0.281													4	7	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11062343	11062344	+	RNA	INS	-	-	AG	rs148978863		TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr21:11062343_11062344insAG	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TAGTAAAAGACAGCAACTTTCA	0.267													2	4	---	---	---	---					
LOC284930	284930	broad.mit.edu	37	22	48208902	48208902	+	RNA	DEL	G	G	-			TCGA-EB-A6QZ-01A-12D-A32N-08	TCGA-EB-A6QZ-10B-01D-A32N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	29ddf94b-7480-4c83-ab28-dc7202e91c05	b9791009-29e6-4baf-aa06-82d79b7e3ca4	g.chr22:48208902delG	ENST00000423737.1	+	0	1125																											AGGAGGAGCAGGCAGGGGGCC	0.587													2	4	---	---	---	---					
