Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SH3TC1	54436	broad.mit.edu	37	4	8217959	8217959	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr4:8217959C>T	ENST00000539824.1	+	6	749	c.375C>T	c.(373-375)acC>acT	p.T125T	SH3TC1_ENST00000245105.3_Silent_p.T201T			Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	201							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						TAAGGCTGACCCACGAGAGCC	0.612000													18	20					0	0	0.004990	0	0
WRN	7486	broad.mit.edu	37	8	31024688	31024688	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr8:31024688C>T	ENST00000298139.5	+	34	4382	c.4133C>T	c.(4132-4134)tCt>tTt	p.S1378F	RP11-363L24.3_ENST00000521252.1_RNA	NM_000553.4	NP_000544.2	Q14191	WRN_HUMAN	Werner syndrome, RecQ helicase-like	1378					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(13)|lung(28)|ovary(3)|skin(3)|upper_aerodigestive_tract(3)	60		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		TTTCCCGGTTCTGAAGAGATC	0.378000			"""Mis, N, F, S"""			"""osteosarcoma, meningioma, others"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Werner syndrome				15	32					0	0	0.024245	0	0
TRIM67	440730	broad.mit.edu	37	1	231339639	231339639	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr1:231339639G>A	ENST00000444294.3	+	6	2413	c.1555G>A	c.(1555-1557)Gag>Aag	p.E519K	TRIM67_ENST00000366652.2_Missense_Mutation_p.E521K|TRIM67_ENST00000366653.5_Missense_Mutation_p.E521K|TRIM67_ENST00000449018.3_Missense_Mutation_p.E459K	NM_001004342.3	NP_001004342.3	Q6ZTA4	TRI67_HUMAN	tripartite motif containing 67	521	Fibronectin type-III.					cytoplasm|cytoskeleton	zinc ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				ACTGCAGCTGGAGAAATGCTG	0.672000													10	16					0	0	0.013537	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39914442	39914442	+	Missense_Mutation	SNP	C	C	T	rs34762911	byFrequency	TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr19:39914442C>T	ENST00000425673.1	+	17	2907	c.2582C>T	c.(2581-2583)tCt>tTt	p.S861F	PLEKHG2_ENST00000458508.2_Missense_Mutation_p.S831F|PLEKHG2_ENST00000378550.1_Intron|PLEKHG2_ENST00000409797.2_Intron|PLEKHG2_ENST00000409794.3_Missense_Mutation_p.S890F			Q9H7P9	PKHG2_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	890					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|pancreas(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	40	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GCCCAGGAGTCTGTCCCCCTG	0.577000													34	41					0	0	0.012213	0	0
OR2A14	135941	broad.mit.edu	37	7	143826661	143826661	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr7:143826661C>T	ENST00000408899.2	+	1	511	c.456C>T	c.(454-456)ttC>ttT	p.F152F		NM_001001659.1	NP_001001659.1	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A, member 14	152					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F152F(2)		large_intestine(4)|lung(17)|skin(1)	22	Melanoma(164;0.0783)					TGTTCAGCTTCCTCCTGGCTC	0.532000													115	132					0	0	0.014410	0	0
DNAH8	1769	broad.mit.edu	37	6	38691132	38691132	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr6:38691132G>A	ENST00000449981.2	+	3	519	c.410G>A	c.(409-411)aGg>aAg	p.R137K	DNAH8_ENST00000359357.3_5'UTR					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AGAGAGGCAAGGGAAAGCCGA	0.313000													86	58					0	0	0.014410	0	0
LIM2	3982	broad.mit.edu	37	19	51883515	51883515	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr19:51883515C>T	ENST00000221973.3	-	5	630	c.586_splice	c.e5-1	p.G196_splice	LIM2_ENST00000596399.1_Splice_Site_p.G154_splice	NM_030657.3	NP_085915.2	P55344	LMIP_HUMAN	lens intrinsic membrane protein 2, 19kDa	154					cell-cell junction assembly	cell junction|integral to membrane	structural constituent of eye lens			endometrium(1)|large_intestine(3)|lung(2)|skin(1)	7		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000214)|OV - Ovarian serous cystadenocarcinoma(262;0.00985)		TGTAGAAAATCCCTGCATGAG	0.537000													10	13					0	0	0.008291	0	0
OR9G4	283189	broad.mit.edu	37	11	56511057	56511057	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr11:56511057G>A	ENST00000302957.3	-	1	230	c.231C>T	c.(229-231)ttC>ttT	p.F77F		NM_001005284.1	NP_001005284.1	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G, member 4	77					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						GATTGCCAATGAAAAAGTACA	0.413000													34	41					0	0	0.021022	0	0
CPEB4	80315	broad.mit.edu	37	5	173317642	173317642	+	Silent	SNP	C	C	G			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr5:173317642C>G	ENST00000265085.5	+	1	2360	c.906C>G	c.(904-906)ggC>ggG	p.G302G	CPEB4_ENST00000334035.5_Silent_p.G302G|CPEB4_ENST00000520867.1_Silent_p.G302G|CPEB4_ENST00000519835.1_Silent_p.G302G	NM_030627.2	NP_085130.2	Q17RY0	CPEB4_HUMAN	cytoplasmic polyadenylation element binding protein 4	302	Poly-Gly.						nucleotide binding|RNA binding			NS(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	20	Renal(175;0.000159)|Lung NSC(126;0.0128)|all_lung(126;0.0202)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GGAGCCCGGGCGGTGGTGGAT	0.582000													54	109					0	0	0.014410	0	0
THBS3	7059	broad.mit.edu	37	1	155175012	155175012	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr1:155175012G>A	ENST00000368378.3	-	3	402	c.382C>T	c.(382-384)Cga>Tga	p.R128*	RP11-263K19.4_ENST00000422665.1_RNA|RP11-263K19.4_ENST00000453136.1_RNA|THBS3_ENST00000457183.2_Intron|RP11-263K19.4_ENST00000430312.1_RNA|THBS3_ENST00000541990.1_5'UTR|THBS3_ENST00000428962.2_Intron|THBS3_ENST00000487250.1_5'UTR	NM_001252607.1|NM_007112.4	NP_001239536.1|NP_009043.1	P49746	TSP3_HUMAN	thrombospondin 3	128	TSP N-terminal.				cell-matrix adhesion	extracellular region|perinuclear region of cytoplasm	calcium ion binding|heparin binding|structural molecule activity			breast(6)|endometrium(4)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(3)	48	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CCTCGGAGTCGCAGGAGAACT	0.622000													19	85					0	0	0.010504	0	0
FAM188B	84182	broad.mit.edu	37	7	30821777	30821777	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr7:30821777C>T	ENST00000265299.6	+	3	445	c.368C>T	c.(367-369)tCa>tTa	p.S123L	INMT-FAM188B_ENST00000458257.1_3'UTR	NM_032222.2	NP_115598.2	Q4G0A6	F188B_HUMAN	family with sequence similarity 188, member B	123										endometrium(1)|large_intestine(5)|lung(19)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						TATGACCTTTCAGATGAAGAT	0.383000													6	20					0	0	0.021553	0	0
OGT	8473	broad.mit.edu	37	X	70784520	70784520	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chrX:70784520G>A	ENST00000373719.3	+	19	2723	c.2506G>A	c.(2506-2508)Ggg>Agg	p.G836R	OGT_ENST00000373701.3_Missense_Mutation_p.G826R	NM_181672.2|NM_181673.2	NP_858058.1|NP_858059.1	O15294	OGT1_HUMAN	O-linked N-acetylglucosamine (GlcNAc) transferase	836					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(5)|liver(3)|lung(9)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Renal(35;0.156)					TTCTCAGTACGGGTTACCAGA	0.398000													26	3					0	0	0.021523	0	0
MCTP2	55784	broad.mit.edu	37	15	95019952	95019952	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr15:95019952G>A	ENST00000357742.4	+	21	2498	c.2498G>A	c.(2497-2499)cGa>cAa	p.R833Q	MCTP2_ENST00000449432.3_3'UTR|MCTP2_ENST00000451018.3_Missense_Mutation_p.R778Q	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	833					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding	p.R833Q(1)		autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			AAGAAGCTTCGAAATCCCTAT	0.363000													29	47					0	0	0.012213	0	0
ANKRD12	23253	broad.mit.edu	37	18	9281083	9281083	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr18:9281083C>T	ENST00000383440.2	+	12	6336	c.6079C>T	c.(6079-6081)Ctt>Ttt	p.L2027F	ANKRD12_ENST00000400020.3_Missense_Mutation_p.L2027F|ANKRD12_ENST00000262126.3_Missense_Mutation_p.L2050F	NM_001083625.2	NP_001077094.1	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12	2050						nucleus				NS(1)|breast(3)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(20)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(2)	65						TTATGTTCCCCTTGTTGATGT	0.418000													35	93					0	0	0.023175	0	0
NOTCH3	4854	broad.mit.edu	37	19	15276755	15276755	+	Missense_Mutation	SNP	C	C	T	rs138265894	by1000genomes	TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr19:15276755C>T	ENST00000263388.2	-	30	5585	c.5510G>A	c.(5509-5511)cGt>cAt	p.R1837H		NM_000435.2	NP_000426.2	Q9UM47	NOTC3_HUMAN	notch 3	1837					Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			CTCGCCAGTACGGTCAGTCCG	0.607000													11	28					0	0	0.010729	0	0
LAMA3	3909	broad.mit.edu	37	18	21489122	21489122	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr18:21489122A>G	ENST00000313654.9	+	55	7262	c.7021A>G	c.(7021-7023)Aag>Gag	p.K2341E	LAMA3_ENST00000587184.1_Missense_Mutation_p.K676E|LAMA3_ENST00000269217.6_Missense_Mutation_p.K732E|LAMA3_ENST00000399516.3_Missense_Mutation_p.K2285E|LAMA3_ENST00000588770.1_3'UTR	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	2341	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AACAGTGAATAAGTTAACCAA	0.373000													22	36					0	0	0.012319	0	0
SLIT2	9353	broad.mit.edu	37	4	20599960	20599960	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr4:20599960C>T	ENST00000504154.1	+	33	3886	c.3634C>T	c.(3634-3636)Cgg>Tgg	p.R1212W	SLIT2_ENST00000503837.1_Missense_Mutation_p.R1208W|SLIT2_ENST00000273739.5_Missense_Mutation_p.R1225W|SLIT2_ENST00000503823.1_Missense_Mutation_p.R1204W	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	1212	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						AGAACTCTATCGGGGGCGTGT	0.473000													52	81					0	0	0.014410	0	0
AC008103.5	0	broad.mit.edu	37	22	18842454	18842454	+	RNA	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr22:18842454G>A	ENST00000412938.1	+	0	2208																											GGCTCAGAGCGGGGCTCACAG	0.632000													4	4					0	0	0.014758	0	0
RPL7	6129	broad.mit.edu	37	8	74203428	74203428	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr8:74203428G>A	ENST00000396467.1	-	6	616	c.478C>T	c.(478-480)Cgc>Tgc	p.R160C	RPL7_ENST00000352983.2_Missense_Mutation_p.R200C|RPL7_ENST00000396466.1_Missense_Mutation_p.R160C|RPL7_ENST00000396465.1_Missense_Mutation_p.R160C	NM_000971.3	NP_000962.2	P18124	RL7_HUMAN	ribosomal protein L7	200				G -> A (in Ref. 1; CAA41026).	endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	DNA binding|mRNA binding|protein homodimerization activity|structural constituent of ribosome			breast(1)|kidney(1)|large_intestine(2)|lung(1)	5	Breast(64;0.0954)		Epithelial(68;0.0193)|all cancers(69;0.0766)|BRCA - Breast invasive adenocarcinoma(89;0.134)			TCTTTGAAGCGTTTTCCAACA	0.373000													11	22					0	0	0.010729	0	0
SNHG14	104472715	broad.mit.edu	37	15	25331750	25331750	+	RNA	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr15:25331750C>T	ENST00000546682.1	+	0	453				SNHG14_ENST00000553108.1_RNA|SNORD116-19_ENST00000384729.1_RNA|SNHG14_ENST00000549804.2_RNA	NR_003361.1																						CCGTCATCCTCGTCGAACTGA	0.468000													55	88					0	0	0.014410	0	0
NDUFV3	4731	broad.mit.edu	37	21	44323607	44323607	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr21:44323607C>T	ENST00000354250.2	+	3	554	c.485C>T	c.(484-486)tCt>tTt	p.S162F	NDUFV3_ENST00000340344.3_Intron|NDUFV3_ENST00000460259.1_3'UTR	NM_021075.3	NP_066553.3	P56181	NDUV3_HUMAN	NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa	0					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I|nucleus	NADH dehydrogenase (ubiquinone) activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	10				STAD - Stomach adenocarcinoma(101;0.0606)	NADH(DB00157)	TCCTCTGATTCTGAATCTGAT	0.522000													70	76					0	0	0.014410	0	0
PCDHGA6	56109	broad.mit.edu	37	5	140754042	140754042	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr5:140754042C>T	ENST00000517434.1	+	1	392	c.392C>T	c.(391-393)cCc>cTc	p.P131L	PCDHGB3_ENST00000576222.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_018919.2|NM_032086.1	NP_061742.1|NP_114475.1														breast(1)|large_intestine(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACAATACACCCCGATTCTTA	0.443000													38	49					0	0	0.025465	0	0
ZFP30	22835	broad.mit.edu	37	19	38126524	38126524	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr19:38126524G>A	ENST00000351218.2	-	6	1475	c.918C>T	c.(916-918)gcC>gcT	p.A306A	ZFP30_ENST00000392144.1_Silent_p.A306A|ZFP30_ENST00000514101.2_Silent_p.A306A|ZFP30_ENST00000589018.1_Intron	NM_014898.2	NP_055713.1	Q9Y2G7	ZFP30_HUMAN	ZFP30 zinc finger protein	306					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	21			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TACACAGAAAGGCCTGACCAC	0.463000													51	61					0	0	0.014410	0	0
SCN11A	11280	broad.mit.edu	37	3	38921496	38921496	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr3:38921496C>T	ENST00000450244.1	-	19	3536	c.3338G>A	c.(3337-3339)gGa>gAa	p.G1113E	SCN11A_ENST00000456224.3_Missense_Mutation_p.G1075E|SCN11A_ENST00000444237.2_Missense_Mutation_p.G1113E|SCN11A_ENST00000302328.3_Missense_Mutation_p.G1113E			Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1113					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.G1113E(1)		NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CTTTCCAAATCCGAAGGCTAC	0.398000													17	18					0	0	0.004990	0	0
MKRN3	7681	broad.mit.edu	37	15	23811097	23811097	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr15:23811097C>T	ENST00000314520.3	+	1	644	c.168C>T	c.(166-168)gcC>gcT	p.A56A	MKRN3_ENST00000568252.1_Silent_p.A56A|MKRN3_ENST00000564592.1_Silent_p.A56A	NM_005664.3	NP_005655.1	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	56						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(33)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		GGGGCTGGGCCCCCTTCCCTG	0.687000													12	28					0	0	0.010729	0	0
B3GNT3	10331	broad.mit.edu	37	19	17922801	17922801	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr19:17922801C>T	ENST00000318683.6	+	3	1136	c.989C>T	c.(988-990)tCc>tTc	p.S330F	B3GNT3_ENST00000595387.1_Missense_Mutation_p.S330F	NM_014256.3	NP_055071.2	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	330					protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	21						CAACGCCTGTCCTCCTTTGAC	0.607000													57	113					0	0	0.014410	0	0
CLVS1	157807	broad.mit.edu	37	8	62212398	62212398	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr8:62212398C>T	ENST00000519846.1	+	3	484	c.12C>T	c.(10-12)gtC>gtT	p.V4V	CLVS1_ENST00000325897.4_Silent_p.V4V|CLVS1_ENST00000518592.1_Intron			Q8IUQ0	CLVS1_HUMAN	clavesin 1	4					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			endometrium(3)|kidney(4)|large_intestine(4)|lung(21)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						TGGGACCAGTCTCTCTTCTTC	0.463000													10	47					0	0	0.010729	0	0
WDR63	126820	broad.mit.edu	37	1	85595757	85595757	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr1:85595757A>C	ENST00000294664.6	+	22	2674	c.2494A>C	c.(2494-2496)Aag>Cag	p.K832Q	WDR63_ENST00000370596.1_Missense_Mutation_p.K793Q|WDR63_ENST00000326813.8_Missense_Mutation_p.K793Q	NM_145172.3	NP_660155.2	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	832										NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)	36				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		TGAGCAAGAAAAGAAAGAAAT	0.338000													69	90					0	0	0.014410	0	0
MPO	4353	broad.mit.edu	37	17	56350985	56350985	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr17:56350985C>T	ENST00000340482.3	-	8	1683	c.1507G>A	c.(1507-1509)Gcc>Acc	p.A503T	MPO_ENST00000225275.3_Missense_Mutation_p.A471T			P05164	PERM_HUMAN	myeloperoxidase	471					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(13)|ovary(2)|pancreas(1)|skin(4)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	46					Cefdinir(DB00535)	TTCCTCATGGCCGTTGGCCCC	0.572000													76	79					0	0	0.014410	0	0
MLIP	90523	broad.mit.edu	37	6	54025545	54025545	+	Missense_Mutation	SNP	C	C	T	rs141526731	byFrequency	TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr6:54025545C>T	ENST00000514921.1	+	8	2527	c.2414C>T	c.(2413-2415)tCt>tTt	p.S805F	MLIP_ENST00000509997.1_Intron|MLIP_ENST00000511744.1_3'UTR|MLIP_ENST00000358276.5_Intron|MLIP_ENST00000370876.2_Intron|MLIP_ENST00000370877.2_Missense_Mutation_p.S177F|MLIP_ENST00000502396.1_Missense_Mutation_p.S816F|MLIP_ENST00000274897.5_Missense_Mutation_p.S281F			Q5VWP3	MLIP_HUMAN	muscular LMNA-interacting protein	281						nuclear envelope|PML body	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(16)|ovary(8)|skin(4)|stomach(1)|urinary_tract(1)	34						cAGCATTCTTCTGATTCTCCT	0.338000													12	22					0	0	0.016723	0	0
KALRN	8997	broad.mit.edu	37	3	124416470	124416470	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr3:124416470C>T	ENST00000360013.3	+	55	7857	c.7730C>T	c.(7729-7731)gCc>gTc	p.A2577V	KALRN_ENST00000428018.2_Missense_Mutation_p.A848V|KALRN_ENST00000291478.4_Missense_Mutation_p.A880V	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2576	Fibronectin type-III.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						CGCCCCATTGCCCAGGAGAGA	0.522000													8	11					0	0	0.004482	0	0
CYP7A1	1581	broad.mit.edu	37	8	59409271	59409271	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr8:59409271A>T	ENST00000301645.3	-	3	937	c.800T>A	c.(799-801)tTg>tAg	p.L267*		NM_000780.3	NP_000771.2	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A, polypeptide 1	267					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(1)|urinary_tract(1)	34		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				AAAGGTGGACAAAGTGTCATT	0.507000									Neonatal Giant Cell Hepatitis				166	116					0	0	0.014410	0	0
IGKV3-11	28914	broad.mit.edu	37	2	89327187	89327187	+	RNA	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr2:89327187C>T	ENST00000483158.1	-	0	41																											TCCATGGTTCCCTCTGGGTCC	0.557000													26	12					0	0	0.021523	0	0
RFWD3	55159	broad.mit.edu	37	16	74685906	74685906	+	Silent	SNP	A	A	G			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr16:74685906A>G	ENST00000361070.4	-	3	730	c.633T>C	c.(631-633)tcT>tcC	p.S211S	RFWD3_ENST00000571750.1_Silent_p.S211S	NM_018124.3	NP_060594.3	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	211					DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	26						CAGAACTACTAGACACCTGCA	0.468000													44	67					0	0	0.008740	0	0
TXNDC2	84203	broad.mit.edu	37	18	9887014	9887014	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr18:9887014C>T	ENST00000306084.6	+	2	737	c.538C>T	c.(538-540)Ccc>Tcc	p.P180S	TXNDC2_ENST00000357775.4_Missense_Mutation_p.P113S|TXNDC2_ENST00000536353.2_Intron	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	180	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						GGGTGACATCCCCAAGGCCCC	0.567000													46	82					0	0	0.010771	0	0
MUC5B	727897	broad.mit.edu	37	11	1267510	1267510	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr11:1267510A>T	ENST00000447027.1	+	31	9467	c.9409A>T	c.(9409-9411)Atc>Ttc	p.I3137F	MUC5B_ENST00000529681.1_Missense_Mutation_p.I3134F|RP11-532E4.2_ENST00000532061.2_RNA			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	3134	17 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GACGACCTGGATCCTCACAGA	0.657000													30	71					0	0	0.008361	0	0
ZNF415	55786	broad.mit.edu	37	19	53611856	53611856	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr19:53611856G>A	ENST00000455735.2	-	7	1906	c.1586C>T	c.(1585-1587)tCa>tTa	p.S529L	ZNF415_ENST00000597748.1_3'UTR|ZNF415_ENST00000595193.1_3'UTR|ZNF415_ENST00000448501.1_Missense_Mutation_p.S529L|ZNF415_ENST00000597503.1_3'UTR|ZNF415_ENST00000421033.1_Missense_Mutation_p.S493L|ZNF415_ENST00000594011.1_3'UTR|ZNF415_ENST00000243643.4_Missense_Mutation_p.S481L|ZNF415_ENST00000440291.1_Missense_Mutation_p.S468L|ZNF415_ENST00000601493.1_Missense_Mutation_p.S251L|ZNF415_ENST00000500065.4_Missense_Mutation_p.S481L			Q09FC8	ZN415_HUMAN	zinc finger protein 415	529					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding			breast(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31				GBM - Glioblastoma multiforme(134;0.0191)		AGTTAGGCTTGAATGCACACT	0.433000													53	69					0	0	0.014410	0	0
SDK2	54549	broad.mit.edu	37	17	71348646	71348646	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr17:71348646G>A	ENST00000392650.3	-	41	5724	c.5724C>T	c.(5722-5724)ttC>ttT	p.F1908F	SDK2_ENST00000388726.3_Silent_p.F1889F|SDK2_ENST00000410094.1_5'UTR	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	1908	Fibronectin type-III 13.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						TGGGGGTGCCGAAACCATAGT	0.647000													24	14					0	0	0.027356	0	0
HIST1H2AA	221613	broad.mit.edu	37	6	25726674	25726674	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr6:25726674C>T	ENST00000297012.3	-	1	116	c.82G>A	c.(82-84)Gta>Ata	p.V28I		NM_170745.3	NP_734466.1	Q96QV6	H2A1A_HUMAN	histone cluster 1, H2aa	28					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|endometrium(2)|large_intestine(2)|lung(8)	13						ATCCGGCCTACGGGAAACTGC	0.547000													37	42					0	0	0.021022	0	0
SSH2	85464	broad.mit.edu	37	17	27959023	27959023	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr17:27959023G>C	ENST00000269033.3	-	15	3259	c.3108C>G	c.(3106-3108)agC>agG	p.S1036R	RP11-68I3.2_ENST00000581474.1_RNA|SSH2_ENST00000540801.1_Missense_Mutation_p.S1063R	NM_033389.2	NP_203747.2	Q76I76	SSH2_HUMAN	slingshot protein phosphatase 2	1036					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CTTGCTCTCCGCTCTTCTCAC	0.478000													48	65					0	0	0.014410	0	0
PCDHB3	56132	broad.mit.edu	37	5	140481738	140481738	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr5:140481738C>T	ENST00000231130.2	+	1	1505	c.1505C>T	c.(1504-1506)tCc>tTc	p.S502F	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		502	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCCTCTCTTCCCTGGTCTCC	0.657000													55	71					0	0	0.014410	0	0
CIB3	117286	broad.mit.edu	37	19	16275623	16275623	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr19:16275623C>T	ENST00000269878.4	-	5	497	c.448G>A	c.(448-450)Gag>Aag	p.E150K	CIB3_ENST00000541493.1_5'UTR|CIB3_ENST00000379859.3_Missense_Mutation_p.E101K	NM_054113.2	NP_473454.1	Q96Q77	CIB3_HUMAN	calcium and integrin binding family member 3	150	EF-hand 3.						calcium ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	16						AGCACCTTCTCACATACCAGG	0.572000													32	36					0	0	0.009535	0	0
WDR53	348793	broad.mit.edu	37	3	196281400	196281400	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr3:196281400G>A	ENST00000332629.5	-	4	1326	c.759C>T	c.(757-759)tcC>tcT	p.S253S	WDR53_ENST00000429115.1_Silent_p.S92S|WDR53_ENST00000433160.1_Silent_p.S94S	NM_182627.1	NP_872433.1	Q7Z5U6	WDR53_HUMAN	WD repeat domain 53	253										breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)	13	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.6e-23)|all cancers(36;1.54e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.29e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		GCAGCAAATAGGATTCTGGGA	0.473000													38	61					0	0	0.025465	0	0
NRAS	4893	broad.mit.edu	37	1	115256530	115256530	+	Missense_Mutation	SNP	G	G	T	rs121913254		TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr1:115256530G>T	ENST00000369535.4	-	3	434	c.181C>A	c.(181-183)Caa>Aaa	p.Q61K		NM_002524.4	NP_002515.1	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61			Q -> K (in neuroblastoma cell).|Q -> R (in lung carcinoma cell and melanoma; dbSNP:rs11554290).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61K(595)|p.Q61E(9)|p.Q61L(3)|p.Q61R(2)|p.G60>?(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TACTCTTCTTGTCCAGCTGTA	0.458000	Q61K(CHP212_AUTONOMIC_GANGLIA)|Q61K(HCC15_LUNG)|Q61K(HS936T_SKIN)|Q61K(HS944T_SKIN)|Q61K(HT1080_SOFT_TISSUE)|Q61K(HUT78_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(M07E_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(NCIH1299_LUNG)|Q61K(NCIH2087_LUNG)|Q61K(OCILY19_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(SKNAS_AUTONOMIC_GANGLIA)|Q61K(SKNSH_AUTONOMIC_GANGLIA)|Q61K(TYKNU_OVARY)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			72	90					9.35569e-46	1.41331e-45	0.014410	1	0
SYT9	143425	broad.mit.edu	37	11	7334696	7334696	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr11:7334696G>A	ENST00000318881.6	+	3	805	c.568G>A	c.(568-570)Gaa>Aaa	p.E190K	SYT9_ENST00000396716.2_Missense_Mutation_p.E158K	NM_175733.3	NP_783860.1	Q86SS6	SYT9_HUMAN	synaptotagmin IX	190						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(2)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	38				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		TCAAAAACAGGAACAGTTGAC	0.413000													13	26					0	0	0.013537	0	0
CUX2	23316	broad.mit.edu	37	12	111785344	111785344	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr12:111785344G>A	ENST00000261726.6	+	22	3830	c.3676G>A	c.(3676-3678)Gag>Aag	p.E1226K		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	1226						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						GATGCGCCGGGAGATGTTGGT	0.652000													57	75					0	0	0.014410	0	0
ATP13A5	344905	broad.mit.edu	37	3	193002723	193002723	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr3:193002723C>T	ENST00000342358.4	-	27	3323	c.3206G>A	c.(3205-3207)cGa>cAa	p.R1069Q	ATP13A5_ENST00000495496.1_5'UTR	NM_198505.2	NP_940907.2	Q4VNC0	AT135_HUMAN	ATPase type 13A5	1069					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(1)|autonomic_ganglia(2)|breast(1)|endometrium(6)|kidney(4)|large_intestine(15)|liver(2)|lung(26)|ovary(5)|prostate(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		GATGGGTTTTCGAAATGGCTT	0.378000													15	18					0	0	0.020292	0	0
CYP4A22	284541	broad.mit.edu	37	1	47606542	47606542	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr1:47606542C>T	ENST00000371891.3	+	2	317	c.286C>T	c.(286-288)Cgt>Tgt	p.R96C	CYP4A22_ENST00000294337.3_Missense_Mutation_p.R96C|CYP4A22_ENST00000485117.1_3'UTR|CYP4A22_ENST00000371890.3_Missense_Mutation_p.R96C|CYP4A22-AS1_ENST00000444042.2_lincRNA	NM_001010969.2	NP_001010969.2	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 22	96						endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						AGGCAAAGTTCGTGTCCAGCT	0.502000													46	80					0	0	0.014410	0	0
SAMD3	154075	broad.mit.edu	37	6	130530752	130530752	+	Splice_Site	SNP	A	A	C			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr6:130530752A>C	ENST00000368134.2	-	7	879	c.269_splice	c.e7-1	p.Y91_splice	SAMD3_ENST00000457563.2_Splice_Site_p.Y115_splice|SAMD3_ENST00000533296.1_5'UTR|SAMD3_ENST00000439090.2_Splice_Site_p.Y91_splice|SAMD3_ENST00000324172.6_Splice_Site_p.Y91_splice|SAMD3_ENST00000532763.1_Intron|SAMD3_ENST00000437477.2_Splice_Site_p.Y91_splice	NM_001258275.1	NP_001245204.1	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3	91										breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(15)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	29				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		TCATCCCTGTAACTAAGAAAG	0.468000													23	11					0	0	0.018920	0	0
PIGG	54872	broad.mit.edu	37	4	502700	502700	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr4:502700C>T	ENST00000453061.2	+	5	948	c.842C>T	c.(841-843)tCc>tTc	p.S281F	PIGG_ENST00000509768.1_Missense_Mutation_p.S192F|PIGG_ENST00000296306.7_Missense_Mutation_p.S192F|PIGG_ENST00000383028.4_Missense_Mutation_p.S148F|PIGG_ENST00000536264.1_Missense_Mutation_p.S159F|PIGG_ENST00000310340.5_Missense_Mutation_p.S281F|PIGG_ENST00000503111.1_Missense_Mutation_p.S192F|PIGG_ENST00000504346.1_Missense_Mutation_p.S192F	NM_001127178.1	NP_001120650.1	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class G	281					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	39						GGGGCCTCCTCCACCGAGGAG	0.443000													34	42					0	0	0.012213	0	0
NUMB	8650	broad.mit.edu	37	14	73783131	73783131	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr14:73783131C>T	ENST00000355058.3	-	6	480		c.e6-1		NUMB_ENST00000454166.4_Splice_Site|NUMB_ENST00000555394.1_Splice_Site|NUMB_ENST00000359560.3_Intron|NUMB_ENST00000555238.1_Splice_Site|NUMB_ENST00000560335.1_Splice_Site|NUMB_ENST00000554521.2_Intron|NUMB_ENST00000554546.1_Intron|NUMB_ENST00000557597.1_Intron|NUMB_ENST00000559312.1_Splice_Site|NUMB_ENST00000544991.3_Splice_Site|NUMB_ENST00000535282.1_Intron|NUMB_ENST00000555738.2_Intron|NUMB_ENST00000356296.4_Splice_Site			P49757	NUMB_HUMAN	numb homolog (Drosophila)						axon guidance|lateral ventricle development|neuroblast division in subventricular zone|positive regulation of neurogenesis	integral to plasma membrane				breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(3)|prostate(1)|skin(3)|urinary_tract(1)	28				BRCA - Breast invasive adenocarcinoma(234;0.00471)|OV - Ovarian serous cystadenocarcinoma(108;0.161)		ACTTCCTTTCCTGGAGGAACA	0.413000													25	39					0	0	0.027356	0	0
ZNF28	7576	broad.mit.edu	37	19	53303978	53303978	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr19:53303978G>A	ENST00000438150.2	-	2	1854	c.961C>T	c.(961-963)Cgt>Tgt	p.R321C	ZNF28_ENST00000414252.2_Missense_Mutation_p.R321C|ZNF28_ENST00000360272.4_Missense_Mutation_p.R321C|ZNF28_ENST00000457749.2_Missense_Mutation_p.R374C			P17035	ZNF28_HUMAN	zinc finger protein 28	374					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|liver(1)|lung(10)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		TGAAGCCTACGATGGCGTGCA	0.383000													38	40					0	0	0.017118	0	0
FPR1	2357	broad.mit.edu	37	19	52250217	52250217	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr19:52250217T>G	ENST00000595042.1	-	3	172	c.31A>C	c.(31-33)Atc>Ctc	p.I11L	FPR1_ENST00000304748.4_Missense_Mutation_p.I11L	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	11			I -> T (in dbSNP:rs5030878).		activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	CCTCCAGAGATGTTCGTGGGG	0.502000													13	10					0	0	0.013537	0	0
KCNK9	51305	broad.mit.edu	37	8	140631316	140631316	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr8:140631316C>T	ENST00000520439.1	-	2	373	c.310G>A	c.(310-312)Gat>Aat	p.D104N	KCNK9_ENST00000303015.1_Missense_Mutation_p.D104N			Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	104						integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			NS(1)|endometrium(9)|kidney(1)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)	43	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			TTGCCCGCATCGGTGCCAGGT	0.612000													7	26					0	0	0.003080	0	0
EVX2	344191	broad.mit.edu	37	2	176947070	176947070	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr2:176947070C>T	ENST00000308618.4	-	2	671	c.535G>A	c.(535-537)Ggt>Agt	p.G179S		NM_001080458.1	NP_001073927.1	Q03828	EVX2_HUMAN	even-skipped homeobox 2	179						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(3)	16			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		CCGGAGCCACCCAGCGCCGCG	0.711000													4	3					0	0	0.014758	0	0
UPF1	5976	broad.mit.edu	37	19	18968188	18968188	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr19:18968188C>T	ENST00000262803.5	+	15	2300	c.2028C>T	c.(2026-2028)gcC>gcT	p.A676A	UPF1_ENST00000599848.1_Silent_p.A687A	NM_002911.3	NP_002902.2	Q92900	RENT1_HUMAN	UPF1 regulator of nonsense transcripts homolog (yeast)	687					cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|RNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40						AGAAGGCGGCCAAGGCCGGGC	0.647000													28	44					0	0	0.010818	0	0
ATP6V0A4	50617	broad.mit.edu	37	7	138437391	138437391	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr7:138437391C>T	ENST00000310018.2	-	11	1290	c.1008G>A	c.(1006-1008)aaG>aaA	p.K336K	ATP6V0A4_ENST00000353492.4_Silent_p.K336K|ATP6V0A4_ENST00000393054.1_Silent_p.K336K	NM_020632.2|NM_130840.2	NP_065683.2|NP_570855.2	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a4	336					cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						CCAGTGCCCTCTTGATACGTG	0.602000													12	25					0	0	0.016723	0	0
PLEKHH1	57475	broad.mit.edu	37	14	68028700	68028700	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr14:68028700C>T	ENST00000329153.5	+	6	585	c.453C>T	c.(451-453)agC>agT	p.S151S		NM_020715.2	NP_065766.1	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	151						cytoskeleton	binding			endometrium(2)|kidney(4)|lung(12)|urinary_tract(1)	19				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		ATCTGAAAAGCCATAATCAGC	0.468000													26	26					0	0	0.027356	0	0
ATP6V0A4	50617	broad.mit.edu	37	7	138432306	138432306	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr7:138432306G>A	ENST00000310018.2	-	13	1466	c.1184C>T	c.(1183-1185)cCc>cTc	p.P395L	ATP6V0A4_ENST00000353492.4_Missense_Mutation_p.P395L|ATP6V0A4_ENST00000393054.1_Missense_Mutation_p.P395L	NM_020632.2|NM_130840.2	NP_065683.2|NP_570855.2	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a4	395					cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						GATGGTGTAGGGGGCTGCGGA	0.577000													13	20					0	0	0.016723	0	0
CDH8	1006	broad.mit.edu	37	16	61935342	61935342	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr16:61935342G>A	ENST00000577390.1	-	3	1242	c.288C>T	c.(286-288)atC>atT	p.I96I	CDH8_ENST00000577730.1_Silent_p.I96I|CDH8_ENST00000299345.6_Silent_p.I96I|CDH8_ENST00000584337.1_Silent_p.I96I	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	96	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		GGATATACTTGATTTTTTTGC	0.378000													17	39					0	0	0.004990	0	0
MDN1	23195	broad.mit.edu	37	6	90368015	90368015	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr6:90368015G>A	ENST00000369393.3	-	90	15211	c.15096C>T	c.(15094-15096)tcC>tcT	p.S5032S	MDN1_ENST00000428876.1_Silent_p.S5032S			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	5032					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TCTGCCCACAGGAGGCATGCT	0.567000													54	129					0	0	0.014410	0	0
CTR9	9646	broad.mit.edu	37	11	10794192	10794192	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr11:10794192T>C	ENST00000361367.2	+	20	2996	c.2570T>C	c.(2569-2571)cTt>cCt	p.L857P		NM_014633.3	NP_055448.1	Q6PD62	CTR9_HUMAN	CTR9, Paf1/RNA polymerase II complex component	857	Lys-rich.				histone H2B ubiquitination|histone monoubiquitination	Cdc73/Paf1 complex|nuclear speck				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|pancreas(1)|stomach(1)	40				all cancers(16;1.64e-07)|Epithelial(150;2.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		CAGAAACTTCTTAAAGAACAG	0.443000													15	20					0	0	0.028581	0	0
BRD1	23774	broad.mit.edu	37	22	50167966	50167966	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr22:50167966G>A	ENST00000216267.8	-	12	3578	c.3092C>T	c.(3091-3093)gCc>gTc	p.A1031V	BRD1_ENST00000404034.1_Missense_Mutation_p.A1031V|BRD1_ENST00000457780.2_3'UTR|BRD1_ENST00000342989.5_Missense_Mutation_p.A757V|BRD1_ENST00000542442.1_Missense_Mutation_p.A719V|BRD1_ENST00000404760.1_Missense_Mutation_p.A1162V	NM_014577.1	NP_055392.1	O95696	BRD1_HUMAN	bromodomain containing 1	1031					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			endometrium(6)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	37		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GATCCGCACGGCCTTCCGGAT	0.572000													64	26					0	0	0.014410	0	0
KCNN3	3782	broad.mit.edu	37	1	154685944	154685944	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr1:154685944G>A	ENST00000271915.3	-	7	2210	c.1895C>T	c.(1894-1896)tCc>tTc	p.S632F	KCNN3_ENST00000361147.4_Missense_Mutation_p.S327F|KCNN3_ENST00000358505.2_Missense_Mutation_p.S319F	NM_002249.5	NP_002240.3	Q9UGI6	KCNN3_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	637	Calmodulin-binding (By similarity).					integral to membrane	calmodulin binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(11)|prostate(4)|skin(1)	28	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			ACTCACCTTGGAAAGGTCCAC	0.552000													28	59					0	0	0.010818	0	0
OR52B2	255725	broad.mit.edu	37	11	6190887	6190887	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr11:6190887G>A	ENST00000530810.1	-	1	751	c.670C>T	c.(670-672)Ctc>Ttc	p.L224F	RP11-290F24.3_ENST00000529961.1_RNA	NM_001004052.1	NP_001004052.1	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B, member 2	224					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(3)|endometrium(1)|large_intestine(1)|lung(15)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACTGCTCGGAGGATCAGTGAG	0.498000													23	38					0	0	0.014323	0	0
MTMR1	8776	broad.mit.edu	37	X	149887149	149887149	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chrX:149887149C>T	ENST00000445323.2	+	4	450	c.329C>T	c.(328-330)cCa>cTa	p.P110L	MTMR1_ENST00000541925.1_Missense_Mutation_p.P8L|MTMR1_ENST00000370390.3_Missense_Mutation_p.P102L|MTMR1_ENST00000451863.2_Missense_Mutation_p.P102L|MTMR1_ENST00000544228.1_Missense_Mutation_p.P102L|MTMR1_ENST00000538506.1_5'UTR|MTMR1_ENST00000542156.1_Missense_Mutation_p.P102L			Q13613	MTMR1_HUMAN	myotubularin related protein 1	102	GRAM.					plasma membrane	protein tyrosine phosphatase activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(5)|ovary(2)|prostate(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					CCACTTTTCCCAGGAGAATCA	0.358000													20	7					0	0	0.010504	0	0
PTPRR	5801	broad.mit.edu	37	12	71139839	71139839	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr12:71139839G>A	ENST00000283228.2	-	6	1218	c.766C>T	c.(766-768)Cag>Tag	p.Q256*	PTPRR_ENST00000549308.1_Nonsense_Mutation_p.Q11*|PTPRR_ENST00000378778.1_Nonsense_Mutation_p.Q50*|PTPRR_ENST00000342084.4_Nonsense_Mutation_p.Q144*|PTPRR_ENST00000440835.2_Nonsense_Mutation_p.Q11*	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	256					in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		AAGGAAAGCTGAAATCTTTCT	0.408000													10	15					0	0	0.006214	0	0
PIGK	10026	broad.mit.edu	37	1	77672386	77672386	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr1:77672386G>A	ENST00000370812.3	-	3	201	c.178C>T	c.(178-180)Cga>Tga	p.R60*	PIGK_ENST00000370813.5_Intron|PIGK_ENST00000445065.1_Intron|PIGK_ENST00000478391.1_Intron|PIGK_ENST00000359130.1_Nonsense_Mutation_p.R60*	NM_005482.2	NP_005473.1	Q92643	GPI8_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class K	60					attachment of GPI anchor to protein|C-terminal protein lipidation|protein thiol-disulfide exchange|proteolysis	GPI-anchor transamidase complex	cysteine-type endopeptidase activity|GPI-anchor transamidase activity|protein binding			endometrium(5)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	19						GCAACATGTCGATAATTAAAC	0.368000													44	78					0	0	0.014410	0	0
LOC101929006	101929006	broad.mit.edu	37	6	29231821	29231821	+	RNA	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr6:29231821G>A	ENST00000441381.1	+	0	292																											GGAACCCAAGGAGCATAAGCC	0.378000													22	38					0	0	0.014323	0	0
FREM2	341640	broad.mit.edu	37	13	39343808	39343808	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr13:39343808C>T	ENST00000280481.7	+	4	5720	c.5504C>T	c.(5503-5505)gCc>gTc	p.A1835V		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	1835	Calx-beta 1.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CAGACCAGGGCCACATGGCGA	0.532000													13	49					0	0	0.016723	0	0
LPO	4025	broad.mit.edu	37	17	56342209	56342209	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr17:56342209C>T	ENST00000262290.4	+	10	1709	c.1393C>T	c.(1393-1395)Cgc>Tgc	p.R465C	LPO_ENST00000582328.1_Missense_Mutation_p.R382C|LPO_ENST00000421678.2_Missense_Mutation_p.R382C|LPO_ENST00000543544.1_Missense_Mutation_p.R406C	NM_006151.2	NP_006142.1	P22079	PERL_HUMAN	lactoperoxidase	465					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			breast(5)|cervix(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30						CTTCGCCTTCCGCTTTGGCCA	0.517000													22	56					0	0	0.010504	0	0
PCSK5	5125	broad.mit.edu	37	9	78638727	78638727	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr9:78638727G>A	ENST00000545128.1	+	4	1023	c.485G>A	c.(484-486)gGa>gAa	p.G162E	PCSK5_ENST00000376752.4_Missense_Mutation_p.G162E|PCSK5_ENST00000376767.3_Missense_Mutation_p.G162E	NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	162	Catalytic.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						GGCTACACGGGAAAGAACATT	0.468000													42	15					0	0	0.007835	0	0
ZNF239	8187	broad.mit.edu	37	10	44052772	44052772	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr10:44052772G>A	ENST00000306006.6	-	2	1408	c.756C>T	c.(754-756)atC>atT	p.I252I	ZNF239_ENST00000535642.1_Silent_p.I252I|ZNF239_ENST00000374446.2_Silent_p.I252I|ZNF239_ENST00000426961.1_Silent_p.I252I	NM_005674.2	NP_005665.2	Q16600	ZN239_HUMAN	zinc finger protein 239	252					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding			endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						CTGCCTGATGGATAAGCAGAC	0.493000													48	89					0	0	0.014410	0	0
ATP2A2	488	broad.mit.edu	37	12	110781221	110781221	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr12:110781221C>T	ENST00000395494.2	+	15	2985	c.2422C>T	c.(2422-2424)Cgt>Tgt	p.R808C	ATP2A2_ENST00000308664.6_Missense_Mutation_p.R835C|ATP2A2_ENST00000539276.2_Missense_Mutation_p.R835C			P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	835					ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(10)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	38						GCTCTTTTTCCGTTACTTGGC	0.418000													39	59					0	0	0.009718	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20495408	20495408	+	RNA	SNP	G	G	A	rs2954587	by1000genomes	TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr15:20495408G>A	ENST00000555186.1	+	0	611					NR_038836.1																						TCTGTGTGAGGAAAATGAATC	0.388000													20	98					0	0	0.007413	0	0
ZNF728	388523	broad.mit.edu	37	19	23159477	23159477	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr19:23159477A>T	ENST00000594710.1	-	4	807	c.662T>A	c.(661-663)aTt>aAt	p.I221N		NM_001267716.1	NP_001254645.1			zinc finger protein 728																		TCCAGTATGAATTCTCTTATA	0.363000													14	13					0	0	0.020292	0	0
OR6C1	390321	broad.mit.edu	37	12	55714500	55714500	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr12:55714500G>A	ENST00000379668.2	+	1	155	c.117G>A	c.(115-117)ggG>ggA	p.G39G		NM_001005182.1	NP_001005182.1	Q96RD1	OR6C1_HUMAN	olfactory receptor, family 6, subfamily C, member 1	39					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(5)|liver(2)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)	25						GCATCACTGGGAACCTGACCC	0.408000													30	32					0	0	0.008361	0	0
HNF1B	6928	broad.mit.edu	37	17	36064997	36064997	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr17:36064997G>A	ENST00000225893.4	-	6	1627	c.1266C>T	c.(1264-1266)ctC>ctT	p.L422L	HNF1B_ENST00000427275.2_Silent_p.L396L|HNF1B_ENST00000561193.1_Silent_p.L396L|HNF1B_ENST00000560016.1_Silent_p.L422L	NM_000458.2|NM_001165923.1	NP_000449.1|NP_001159395.1	P35680	HNF1B_HUMAN	HNF1 homeobox B	422					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(6)|kidney(3)|large_intestine(2)|liver(1)|lung(3)|ovary(3)|prostate(1)|skin(2)	28		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			TATGGTGGGAGAGGCTGTGGA	0.468000													169	254					0	0	0.014410	0	0
MROH9	80133	broad.mit.edu	37	1	170967503	170967503	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr1:170967503C>T	ENST00000367758.3	+	15	1783	c.1684C>T	c.(1684-1686)Cct>Tct	p.P562S	MROH9_ENST00000367759.4_Intron	NM_025063.2	NP_079339.2			maestro heat-like repeat family member 9																		CGTATCTCTCCCTCTGAATGT	0.398000													28	30					0	0	0.027356	0	0
ZNF880	400713	broad.mit.edu	37	19	52887585	52887585	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr19:52887585G>A	ENST00000422689.2	+	4	767	c.752G>A	c.(751-753)cGa>cAa	p.R251Q		NM_001145434.1	NP_001138906.1	Q6PDB4	ZN880_HUMAN	zinc finger protein 880	251					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(2)|skin(1)	10						CTCTTCAATCGAATTTCACTC	0.403000													14	11					0	0	0.024245	0	0
PSMB5	5693	broad.mit.edu	37	14	23502818	23502818	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr14:23502818C>A	ENST00000361611.6	-	2	527	c.264G>T	c.(262-264)caG>caT	p.Q88H	PSMB5_ENST00000460922.2_Intron|AL132780.1_ENST00000385031.1_RNA|PSMB5_ENST00000425762.2_5'UTR|PSMB5_ENST00000493471.2_Missense_Mutation_p.Q88H	NM_002797.3	NP_002788.1	P28074	PSB5_HUMAN	proteasome (prosome, macropain) subunit, beta type, 5	88					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus	protein binding|threonine-type endopeptidase activity			kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)	7	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.0121)	Bortezomib(DB00188)	TCTTCACCGTCTGGGAGGCAA	0.552000													23	21					3.01185e-09	4.43654e-09	0.021523	1	0
AK7	122481	broad.mit.edu	37	14	96949519	96949519	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr14:96949519T>A	ENST00000267584.4	+	16	1981	c.1937T>A	c.(1936-1938)gTg>gAg	p.V646E		NM_152327.3	NP_689540.2	Q96M32	KAD7_HUMAN	adenylate kinase 7	646	Glu-rich.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			breast(2)|cervix(2)|endometrium(3)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		CAGGAGGCCGTGGAGATGGCA	0.592000													6	14					0	0	0.021553	0	0
INTS6-AS1	100507398	broad.mit.edu	37	13	52035102	52035102	+	RNA	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr13:52035102C>T	ENST00000594959.1	+	0	411				INTS6-AS1_ENST00000596180.1_RNA|INTS6-AS1_ENST00000593709.1_RNA|INTS6-AS1_ENST00000595997.1_RNA|INTS6-AS1_ENST00000596303.1_RNA|INTS6-AS1_ENST00000602089.1_RNA|INTS6-AS1_ENST00000594358.1_RNA|INTS6-AS1_ENST00000596050.1_RNA|INTS6-AS1_ENST00000601572.1_RNA|RPS4XP16_ENST00000595905.1_RNA|INTS6-AS1_ENST00000601034.1_RNA|INTS6-AS1_ENST00000601318.1_RNA|INTS6-AS1_ENST00000595424.1_RNA|INTS6-AS1_ENST00000595435.1_RNA|INTS6-AS1_ENST00000593672.1_RNA|INTS6-AS1_ENST00000600477.1_RNA|INTS6-AS1_ENST00000594488.1_RNA|INTS6-AS1_ENST00000599315.1_RNA|INTS6-AS1_ENST00000594604.1_RNA|INTS6-AS1_ENST00000598864.1_RNA|INTS6-AS1_ENST00000434512.1_RNA|INTS6-AS1_ENST00000593429.1_RNA|INTS6-AS1_ENST00000597745.1_RNA|INTS6-AS1_ENST00000593928.1_RNA																							GTCGCACCATCCGCTACACTG	0.438000													5	19					0	0	0.014758	0	0
BORA	79866	broad.mit.edu	37	13	73305505	73305505	+	Silent	SNP	T	T	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr13:73305505T>A	ENST00000390667.5	+	3	337	c.240T>A	c.(238-240)gcT>gcA	p.A80A	BORA_ENST00000464754.1_3'UTR|BORA_ENST00000377815.3_Intron	NM_024808.2	NP_079084.2	Q6PGQ7	BORA_HUMAN	bora, aurora kinase A activator	80					cell division|mitosis|regulation of mitosis|regulation of mitotic spindle organization|regulation of protein localization		protein kinase binding										ATCGTCAAGCTTTATACTTAA	0.338000													40	25					0	0	0.027894	0	0
OR10T2	128360	broad.mit.edu	37	1	158368849	158368849	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr1:158368849G>A	ENST00000334438.1	-	1	407	c.408C>T	c.(406-408)atC>atT	p.I136I		NM_001004475.1	NP_001004475.1	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T, member 2	136					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_hematologic(112;0.0378)					TTTTGTTTATGATGAGTGTGT	0.453000													41	62					0	0	0.014410	0	0
SLC13A5	284111	broad.mit.edu	37	17	6599122	6599122	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr17:6599122C>T	ENST00000433363.2	-	7	1211	c.978G>A	c.(976-978)ctG>ctA	p.L326L	SLC13A5_ENST00000381074.4_Silent_p.L283L|SLC13A5_ENST00000573648.1_Silent_p.L326L|SLC13A5_ENST00000293800.6_Silent_p.L309L	NM_177550.3	NP_808218.1	Q86YT5	S13A5_HUMAN	solute carrier family 13 (sodium-dependent citrate transporter), member 5	326						integral to membrane	citrate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|prostate(5)|skin(3)|urinary_tract(1)	26						ACAGGATGACCAGCAGGAAGA	0.567000													83	19					0	0	0.014410	0	0
COQ6	51004	broad.mit.edu	37	14	74422197	74422197	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr14:74422197C>T	ENST00000334571.2	+	3	382	c.342C>T	c.(340-342)gcC>gcT	p.A114A	COQ6_ENST00000394026.4_Silent_p.A89A|COQ6_ENST00000554920.1_Silent_p.A114A|COQ6_ENST00000238709.4_Intron	NM_182476.2	NP_872282.1	Q9Y2Z9	COQ6_HUMAN	coenzyme Q6 monooxygenase	114					ubiquinone biosynthetic process	mitochondrion	flavin adenine dinucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			breast(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	16				BRCA - Breast invasive adenocarcinoma(234;0.00337)		GATACAGAGCCTTTCGGCGAA	0.458000													48	57					0	0	0.014410	0	0
SBF1	6305	broad.mit.edu	37	22	50903030	50903030	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr22:50903030C>T	ENST00000380817.2	-	14	1752	c.1569G>A	c.(1567-1569)aaG>aaA	p.K523K	SBF1_ENST00000348911.6_Silent_p.K524K|SBF1_ENST00000390679.3_Silent_p.K523K	NM_002972.2	NP_002963.2	O95248	MTMR5_HUMAN	SET binding factor 1	523					protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(8)|large_intestine(3)|lung(18)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	43		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		CACCCTGCATCTTGGCTGCAG	0.692000													45	10					0	0	0.013114	0	0
ADH1C	126	broad.mit.edu	37	4	100260777	100260777	+	RNA	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr4:100260777C>T	ENST00000515683.1	-	0	1411					NM_000669.3	NP_000660.1	P00326	ADH1G_HUMAN	alcohol dehydrogenase 1C (class I), gamma polypeptide						ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding								OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	TTTATTTTTTCAAAAGGTAAA	0.368000													22	38					0	0	0.012319	0	0
ACE	1636	broad.mit.edu	37	17	61562671	61562671	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr17:61562671G>A	ENST00000577647.1	+	2	319	c.274G>A	c.(274-276)Gag>Aag	p.E92K	ACE_ENST00000490216.2_Missense_Mutation_p.E92K|ACE_ENST00000428043.1_Missense_Mutation_p.E666K|ACE_ENST00000421982.2_5'UTR|ACE_ENST00000413513.3_Missense_Mutation_p.E92K|ACE_ENST00000290863.6_Missense_Mutation_p.E92K|ACE_ENST00000290866.4_Missense_Mutation_p.E666K			P12821	ACE_HUMAN	angiotensin I converting enzyme	666	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	GGTGTGGAACGAGTATGCCGA	0.562000													17	41					0	0	0.028581	0	0
OR5B21	219968	broad.mit.edu	37	11	58275040	58275040	+	Missense_Mutation	SNP	G	G	A	rs140880239	by1000genomes	TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr11:58275040G>A	ENST00000360374.2	-	1	538	c.539C>T	c.(538-540)cCc>cTc	p.P180L		NM_001005218.1	NP_001005218.1	A6NL26	OR5BL_HUMAN	olfactory receptor, family 5, subfamily B, member 21	180					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CAGGAGTGGGGGAATGTCACA	0.483000													16	25					0	0	0.024245	0	0
RP11-159L20.2	0	broad.mit.edu	37	14	31290983	31290983	+	RNA	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr14:31290983G>A	ENST00000554665.1	-	0	208																											AAGAAGCCAAGATCAAGTTTG	0.413000													3	8					0	0	0.004672	0	0
TCF19	6941	broad.mit.edu	37	6	31127306	31127306	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr6:31127306C>T	ENST00000376257.3	+	2	814	c.60C>T	c.(58-60)acC>acT	p.T20T	TCF19_ENST00000376255.4_Silent_p.T20T	NM_007109.2	NP_009040.2	Q9Y242	TCF19_HUMAN	transcription factor 19	20					cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)	9						ATCTCTACACCTTCCACCCCC	0.682000													9	8					0	0	0.008291	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70714259	70714259	+	RNA	SNP	A	A	G	rs7144638	by1000genomes	TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr14:70714259A>G	ENST00000530196.1	-	0	259					NR_003951.1																						CACCACTTCCAGGGAAGTGAA	0.527000													4	85					0	0	0.021553	0	0
OR51E2	81285	broad.mit.edu	37	11	4703075	4703075	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr11:4703075G>A	ENST00000396950.3	-	2	1106	c.867C>T	c.(865-867)atC>atT	p.I289I		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	289					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		CACCATAGATGATGGGATTGA	0.522000													30	36					0	0	0.007291	0	0
POM121L12	285877	broad.mit.edu	37	7	53103886	53103886	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr7:53103886C>T	ENST00000408890.4	+	1	538	c.522C>T	c.(520-522)acC>acT	p.T174T		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	174										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						ACCCCTGCACCCGGGAGACTC	0.716000													14	26					0	0	0.024245	0	0
PLCH1	23007	broad.mit.edu	37	3	155241775	155241775	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr3:155241775G>A	ENST00000460012.1	-	11	1648	c.1291C>T	c.(1291-1293)Cac>Tac	p.H431Y	PLCH1_ENST00000447496.2_Missense_Mutation_p.H449Y|PLCH1_ENST00000414191.1_Missense_Mutation_p.H431Y|PLCH1_ENST00000340059.7_Missense_Mutation_p.H449Y|PLCH1_ENST00000334686.6_Missense_Mutation_p.H431Y|PLCH1_ENST00000494598.1_Missense_Mutation_p.H449Y			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	449	PI-PLC X-box.				lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TCCCCAAGGTGATAAGGCAAC	0.403000													75	94					0	0	0.014410	0	0
PTPRC	5788	broad.mit.edu	37	1	198711436	198711436	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr1:198711436G>A	ENST00000367376.2	+	25	2802	c.2631G>A	c.(2629-2631)gtG>gtA	p.V877V	PTPRC_ENST00000348564.6_Silent_p.V718V|PTPRC_ENST00000594404.1_Silent_p.V716V|PTPRC_ENST00000352140.3_Silent_p.V829V|PTPRC_ENST00000442510.2_Silent_p.V879V	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	877	Tyrosine-protein phosphatase 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						AGAACAAAGTGGATGTTTATG	0.438000													55	74					0	0	0.014410	0	0
NECAB1	64168	broad.mit.edu	37	8	91937824	91937824	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr8:91937824C>T	ENST00000417640.2	+	7	893	c.556C>T	c.(556-558)Cga>Tga	p.R186*		NM_022351.4	NP_071746.1	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	186					antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(7)	12			BRCA - Breast invasive adenocarcinoma(11;0.0499)			ATCAAGCCGCCGAGTCCAGAG	0.453000													24	15					0	0	0.021523	0	0
SPINK5	11005	broad.mit.edu	37	5	147486618	147486618	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr5:147486618C>T	ENST00000359874.3	+	17	1571	c.1498C>T	c.(1498-1500)Cgg>Tgg	p.R500W	SPINK5_ENST00000256084.7_Missense_Mutation_p.R500W|SPINK5_ENST00000398454.1_Missense_Mutation_p.R500W	NM_001127698.1	NP_001121170.1	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5	500	Kazal-like 8.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(8)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGTGAATTTCGGGACCAAGT	0.423000													39	51					0	0	0.008740	0	0
RNF17	56163	broad.mit.edu	37	13	25435510	25435510	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr13:25435510C>T	ENST00000255324.5	+	27	3931	c.3879C>T	c.(3877-3879)ctC>ctT	p.L1293L	RNF17_ENST00000339524.3_Silent_p.L345L|RNF17_ENST00000381921.1_Silent_p.L1293L	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1293					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		CTTGTCAGCTCCATAATACCA	0.284000													79	136					0	0	0.014410	0	0
IRGQ	126298	broad.mit.edu	37	19	44096256	44096256	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr19:44096256G>A	ENST00000422989.1	-	3	1949	c.1794C>T	c.(1792-1794)caC>caT	p.H598H	L34079.2_ENST00000594374.1_Intron|IRGQ_ENST00000601520.1_Intron|IRGQ_ENST00000602269.1_Silent_p.H598H	NM_001007561.2	NP_001007562.1	Q8WZA9	IRGQ_HUMAN	immunity-related GTPase family, Q	598	Ala-rich.						protein binding			endometrium(2)|large_intestine(4)|lung(6)|ovary(2)|pancreas(1)|prostate(3)	18		Prostate(69;0.0199)				GCAGGACGCCGTGAGCCGCTC	0.706000													7	59					0	0	0.003080	0	0
ECSIT	51295	broad.mit.edu	37	19	11623974	11623974	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr19:11623974G>A	ENST00000270517.7	-	4	770	c.635C>T	c.(634-636)cCc>cTc	p.P212L	ECSIT_ENST00000588998.1_Intron|ECSIT_ENST00000592312.1_Missense_Mutation_p.P96L|ECSIT_ENST00000417981.2_Intron|ECSIT_ENST00000591352.1_Intron|ECSIT_ENST00000591104.1_Missense_Mutation_p.P212L|ECSIT_ENST00000252440.7_Missense_Mutation_p.P212L	NM_016581.4	NP_057665.2	Q9BQ95	ECSIT_HUMAN	ECSIT signalling integrator	212					innate immune response|regulation of oxidoreductase activity	mitochondrion	oxidoreductase activity, acting on NADH or NADPH|protein binding			kidney(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	11						CACTGGGAAGGGGTTGACGTT	0.587000													25	42					0	0	0.016522	0	0
OTUD7A	161725	broad.mit.edu	37	15	31776565	31776565	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr15:31776565G>C	ENST00000382902.1	-	11	1826	c.1734C>G	c.(1732-1734)agC>agG	p.S578R	OTUD7A_ENST00000307050.4_Missense_Mutation_p.S571R			Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	571						cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			endometrium(7)|large_intestine(4)|lung(11)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	30		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		ACTCCTCCTTGCTGCCCTTGC	0.692000													11	17					0	0	0.016723	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	163580	163580	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr5:163580C>T	ENST00000283426.6	+	11	2375	c.2325C>T	c.(2323-2325)agC>agT	p.S775S		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	775					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		ATGCCAGGAGCCCCCCGGTCA	0.652000													17	26					0	0	0.028581	0	0
DDR2	4921	broad.mit.edu	37	1	162731078	162731078	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr1:162731078T>G	ENST00000367922.2	+	10	1371	c.933T>G	c.(931-933)agT>agG	p.S311R	DDR2_ENST00000367921.3_Missense_Mutation_p.S311R	NM_001014796.1	NP_001014796.1	Q16832	DDR2_HUMAN	discoidin domain receptor tyrosine kinase 2	311					cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|kidney(1)|lung(2)|ovary(1)|skin(1)	7	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			CTGAAGCCAGTGAGTGGGAAC	0.522000													14	30					0	0	0.020292	0	0
CCT6P3	643180	broad.mit.edu	37	7	64529093	64529093	+	RNA	SNP	G	G	C			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr7:64529093G>C	ENST00000426828.1	+	0	783					NR_033416.1																						ATAGGGAATTGACCCCTTTTC	0.333000													3	3					0	0	0.014758	0	0
OR6C74	254783	broad.mit.edu	37	12	55641256	55641256	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr12:55641256G>A	ENST00000343870.4	+	1	275	c.185G>A	c.(184-186)cGa>cAa	p.R62Q		NM_001005490.1	NP_001005490.1	A6NCV1	O6C74_HUMAN	olfactory receptor, family 6, subfamily C, member 74	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R62Q(1)		central_nervous_system(1)|large_intestine(3)|lung(7)|prostate(1)	12						TTCTTCCTCCGAAATTTCTCA	0.383000													59	74					0	0	0.014410	0	0
NIN	51199	broad.mit.edu	37	14	51223836	51223836	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr14:51223836G>A	ENST00000245441.5	-	18	4102	c.3912C>T	c.(3910-3912)ttC>ttT	p.F1304F	NIN_ENST00000382041.3_Silent_p.F1304F|NIN_ENST00000382043.4_Intron|NIN_ENST00000324330.9_Silent_p.F1304F|NIN_ENST00000530997.2_Silent_p.F1304F|NIN_ENST00000453196.1_Silent_p.F1304F|NIN_ENST00000389868.3_Intron	NM_020921.3	NP_065972.3	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	1304					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					CCAGGCTGAGGAATGTTTCAG	0.428000			T	PDGFRB	MPD								50	62					0	0	0.014410	0	0
HNF4G	3174	broad.mit.edu	37	8	76468232	76468232	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr8:76468232G>A	ENST00000396423.2	+	6	755	c.631G>A	c.(631-633)Gct>Act	p.A211T	HNF4G_ENST00000354370.1_Missense_Mutation_p.A174T	NM_004133.4	NP_004124.4	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	174					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	37	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			ACTGTTGAGAGCTCACGCAGG	0.313000													30	11					0	0	0.013726	0	0
HUWE1	10075	broad.mit.edu	37	X	53620471	53620471	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chrX:53620471G>A	ENST00000342160.3	-	31	4051	c.3594C>T	c.(3592-3594)ttC>ttT	p.F1198F	HUWE1_ENST00000218328.8_Silent_p.F1198F|HUWE1_ENST00000262854.6_Silent_p.F1198F			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	1198					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						AGGCATCTAGGAATTCTCCTG	0.498000													24	1					0	0	0.021523	0	0
MUC16	94025	broad.mit.edu	37	19	8993398	8993398	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr19:8993398C>T	ENST00000397910.4	-	66	41894	c.41691G>A	c.(41689-41691)ctG>ctA	p.L13897L	MUC16_ENST00000380951.5_Silent_p.L538L	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13900	SEA 12.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTCCCTGTCCAGTGTGTAGG	0.567000													33	70					0	0	0.023175	0	0
PDE5A	8654	broad.mit.edu	37	4	120427082	120427082	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr4:120427082C>T	ENST00000354960.3	-	17	2514	c.2195G>A	c.(2194-2196)cGa>cAa	p.R732Q	RP11-33B1.1_ENST00000498873.1_RNA|PDE5A_ENST00000264805.5_Missense_Mutation_p.R690Q|PDE5A_ENST00000394439.1_Missense_Mutation_p.R680Q	NM_001083.3	NP_001074.2	O76074	PDE5A_HUMAN	phosphodiesterase 5A, cGMP-specific	732	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding	p.G733delG(1)		breast(4)|endometrium(2)|kidney(3)|large_intestine(8)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	27					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	AAATTCTCCTCGCCTCCTACA	0.318000													11	23					0	0	0.010729	0	0
CASC5	57082	broad.mit.edu	37	15	40901081	40901081	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr15:40901081C>T	ENST00000346991.5	+	5	562	c.172C>T	c.(172-174)Cga>Tga	p.R58*	CASC5_ENST00000527044.1_Nonsense_Mutation_p.R58*|CASC5_ENST00000399668.2_Nonsense_Mutation_p.R58*			Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5	58	Interaction with BUB1 and BUB1B.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(13)|lung(16)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		AAACTCTCGTCGAGTCAGCTT	0.313000													24	29					0	0	0.024334	0	0
ZSCAN2	54993	broad.mit.edu	37	15	85165085	85165085	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr15:85165085G>A	ENST00000448803.2	+	3	1951	c.1659G>A	c.(1657-1659)ttG>ttA	p.L553L	ZSCAN2_ENST00000546148.1_Silent_p.L553L|ZSCAN2_ENST00000541040.1_Intron|ZSCAN2_ENST00000538076.1_Intron|ZSCAN2_ENST00000485222.2_Intron|ZSCAN2_ENST00000327179.6_Silent_p.L552L|ZSCAN2_ENST00000358472.3_Silent_p.L403L	NM_181877.3	NP_870992.2	Q7Z7L9	ZSCA2_HUMAN	zinc finger and SCAN domain containing 2	553					cell differentiation|multicellular organismal development|spermatogenesis|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(7)|liver(2)|lung(4)|ovary(1)|pancreas(1)	19				UCEC - Uterine corpus endometrioid carcinoma (272;0.168)|all cancers(203;5.43e-22)		GAGCCCATTTGGGAGACAAGC	0.567000													56	77					0	0	0.014410	0	0
VARS	7407	broad.mit.edu	37	6	31749631	31749631	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr6:31749631G>A	ENST00000375663.3	-	19	2780	c.2340C>T	c.(2338-2340)ctC>ctT	p.L780L	VARS_ENST00000482996.1_5'UTR|VARS_ENST00000444930.2_3'UTR	NM_006295.2	NP_006286.1	P26640	SYVC_HUMAN	valyl-tRNA synthetase	780					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	30					L-Valine(DB00161)	TGCCTTGCTGGAGACTGATCT	0.617000													146	200					0	0	0.014410	0	0
CPEB4	80315	broad.mit.edu	37	5	173317643	173317643	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr5:173317643G>T	ENST00000265085.5	+	1	2361	c.907G>T	c.(907-909)Ggt>Tgt	p.G303C	CPEB4_ENST00000334035.5_Missense_Mutation_p.G303C|CPEB4_ENST00000520867.1_Missense_Mutation_p.G303C|CPEB4_ENST00000519835.1_Missense_Mutation_p.G303C	NM_030627.2	NP_085130.2	Q17RY0	CPEB4_HUMAN	cytoplasmic polyadenylation element binding protein 4	303	Poly-Gly.						nucleotide binding|RNA binding			NS(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	20	Renal(175;0.000159)|Lung NSC(126;0.0128)|all_lung(126;0.0202)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GAGCCCGGGCGGTGGTGGATA	0.582000													55	105					6.30371e-39	9.48227e-39	0.014410	1	0
TRAV26-2	28656	broad.mit.edu	37	14	22671215	22671215	+	RNA	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr14:22671215C>T	ENST00000390460.1	+	0	280																											GATCCTGCACCGTGCTACCTT	0.502000													10	17					0	0	0.010729	0	0
INADL	10207	broad.mit.edu	37	1	62594552	62594552	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr1:62594552G>A	ENST00000371158.2	+	41	5320	c.5206G>A	c.(5206-5208)Gat>Aat	p.D1736N		NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	1736	PDZ 10.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						GCAACCTTTGGATGGGCTGTC	0.453000													59	91					0	0	0.014410	0	0
KCNK9	51305	broad.mit.edu	37	8	140630869	140630869	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr8:140630869C>T	ENST00000520439.1	-	2	820	c.757G>A	c.(757-759)Gat>Aat	p.D253N	KCNK9_ENST00000303015.1_Missense_Mutation_p.D253N			Q9NPC2	KCNK9_HUMAN	potassium channel, subfamily K, member 9	253						integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity			NS(1)|endometrium(9)|kidney(1)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)	43	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			CGCCGCTCATCCTCACTGTTC	0.597000													82	30					0	0	0.014410	0	0
MXRA5	25878	broad.mit.edu	37	X	3228149	3228149	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chrX:3228149G>A	ENST00000217939.6	-	7	8249	c.8095C>T	c.(8095-8097)Cgt>Tgt	p.R2699C		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	2699	Ig-like C2-type 11.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GAGGCCTCACGAACCGTGAGG	0.597000													32	6					0	0	0.017118	0	0
CLCN3	1182	broad.mit.edu	37	4	170601278	170601278	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr4:170601278C>T	ENST00000513761.1	+	3	797	c.238C>T	c.(238-240)Cca>Tca	p.P80S	CLCN3_ENST00000347613.4_Missense_Mutation_p.P80S|CLCN3_ENST00000504131.2_Missense_Mutation_p.P63S|CLCN3_ENST00000360642.3_Missense_Mutation_p.P80S	NM_001829.3	NP_001820.2	P51790	CLCN3_HUMAN	chloride channel, voltage-sensitive 3	80					endosomal lumen acidification	cell surface|early endosome membrane|Golgi membrane|integral to membrane|late endosome membrane|transport vesicle membrane	antiporter activity|ATP binding|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|voltage-gated chloride channel activity			breast(5)|endometrium(3)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	29		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0233)|LUSC - Lung squamous cell carcinoma(193;0.131)		TGAACCAATTCCAGGTGTTGG	0.358000													23	22					0	0	0.021523	0	0
TRBV7-3	28595	broad.mit.edu	37	7	142247149	142247149	+	RNA	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr7:142247149G>A	ENST00000390361.3	-	0	356																											GAGTCCCCCCGCTCTGTGCGC	0.572000													21	44					0	0	0.012319	0	0
HEXIM2	124790	broad.mit.edu	37	17	43246478	43246478	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr17:43246478G>A	ENST00000307275.3	+	4	599	c.163G>A	c.(163-165)Gat>Aat	p.D55N	RP13-890H12.2_ENST00000589796.1_RNA|HEXIM2_ENST00000592695.1_Missense_Mutation_p.D55N|HEXIM2_ENST00000591576.1_Missense_Mutation_p.D55N	NM_144608.1	NP_653209.1	Q96MH2	HEXI2_HUMAN	hexamethylene bis-acetamide inducible 2	55					negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding			endometrium(1)|large_intestine(3)|lung(1)	5						CCACTCAGAGGATGAAGATCT	0.667000													65	104					0	0	0.014410	0	0
KALRN	8997	broad.mit.edu	37	3	124438176	124438176	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr3:124438176C>T	ENST00000360013.3	+	60	8947	c.8820C>T	c.(8818-8820)ccC>ccT	p.P2940P	KALRN_ENST00000428018.2_Silent_p.P1211P|KALRN_ENST00000291478.4_Silent_p.P1243P	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2939					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GGCTGCAGCCCCATAATGGCA	0.532000													21	48					0	0	0.010504	0	0
CASP14	23581	broad.mit.edu	37	19	15164549	15164549	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr19:15164549C>T	ENST00000427043.3	+	4	491	c.183C>T	c.(181-183)ttC>ttT	p.F61F	CASP14_ENST00000221740.1_Silent_p.F61F	NM_012114.2	NP_036246.1	P31944	CASPE_HUMAN	caspase 14, apoptosis-related cysteine peptidase	61					apoptosis|cell differentiation|epidermis development|proteolysis	cytoplasm|nucleus	cysteine-type endopeptidase activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|prostate(1)|skin(3)	26						TCCAGCAATTCCAGGAAGAGC	0.562000													27	38					0	0	0.024334	0	0
SPHKAP	80309	broad.mit.edu	37	2	228886527	228886527	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr2:228886527C>T	ENST00000392056.3	-	6	643	c.597G>A	c.(595-597)ctG>ctA	p.L199L	SPHKAP_ENST00000344657.5_Silent_p.L199L	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	199						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TGTCATCCTCCAGTTTCAAGA	0.463000													21	17					0	0	0.012319	0	0
DMRTC2	63946	broad.mit.edu	37	19	42351543	42351543	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr19:42351543C>A	ENST00000269945.3	+	2	98	c.47C>A	c.(46-48)tCt>tAt	p.S16Y	DMRTC2_ENST00000602098.1_3'UTR|DMRTC2_ENST00000596827.1_Missense_Mutation_p.S16Y	NM_001040283.1	NP_001035373.1	Q8IXT2	DMRTD_HUMAN	DMRT-like family C2	16					cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	10						CCCTTAGACTCTGCCCCCTGG	0.627000													44	58					1.61004e-24	2.40153e-24	0.014410	1	0
DPYD	1806	broad.mit.edu	37	1	98144692	98144692	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr1:98144692G>A	ENST00000370192.3	-	8	909	c.809C>T	c.(808-810)aCt>aTt	p.T270I		NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	270					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TTCTTTCAAAGTGCTAAGAGT	0.264000													3	7					0	0	0.014758	0	0
WBSCR17	64409	broad.mit.edu	37	7	71175806	71175806	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr7:71175806C>T	ENST00000333538.5	+	10	2195	c.1561C>T	c.(1561-1563)Ctc>Ttc	p.L521F	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	521	Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				CACCACACTCCTCCCTGACAC	0.617000													28	55					0	0	0.006320	0	0
SEMA5A	9037	broad.mit.edu	37	5	9052067	9052067	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr5:9052067G>A	ENST00000382496.5	-	20	3428	c.2763C>T	c.(2761-2763)atC>atT	p.I921I		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	921	TSP type-1 7.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						GGAACAGGAGGATGCACTGGC	0.592000													13	31					0	0	0.016723	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90161902	90161902	+	RNA	SNP	A	A	G	rs6500471	by1000genomes	TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr16:90161902A>G	ENST00000564451.1	+	0	1255				TUBB8P7_ENST00000567960.1_RNA														p.K213R(8)									ATATGTTCCAAGACCCTAAAA	0.537000													4	34					0	0	0.009096	0	0
FGL1	2267	broad.mit.edu	37	8	17739657	17739657	+	Missense_Mutation	SNP	C	C	T	rs140117264		TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr8:17739657C>T	ENST00000398056.2	-	5	910	c.95G>A	c.(94-96)cGg>cAg	p.R32Q	FGL1_ENST00000398054.1_Missense_Mutation_p.R32Q|RP11-156K13.2_ENST00000519368.1_RNA|FGL1_ENST00000522444.1_Missense_Mutation_p.R32Q|FGL1_ENST00000518650.1_Missense_Mutation_p.R32Q|FGL1_ENST00000381841.2_Missense_Mutation_p.R32Q|FGL1_ENST00000427924.1_Missense_Mutation_p.R32Q|FGL1_ENST00000381840.2_Missense_Mutation_p.R32Q			Q08830	FGL1_HUMAN	fibrinogen-like 1	32					signal transduction	fibrinogen complex	receptor binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)	13				Colorectal(111;0.0573)|COAD - Colon adenocarcinoma(73;0.215)		GGCTCTGAGCCGCATCTGCTC	0.493000													23	47					0	0	0.021523	0	0
PCDHB2	56133	broad.mit.edu	37	5	140475273	140475273	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr5:140475273C>T	ENST00000194155.4	+	1	1047	c.899C>T	c.(898-900)tCg>tTg	p.S300L		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		300	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding	p.S300*(1)		NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGTGCAAAATCGGGAGAACTG	0.413000													28	55					0	0	0.006320	0	0
WRN	7486	broad.mit.edu	37	8	31000192	31000192	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr8:31000192C>T	ENST00000298139.5	+	27	3533	c.3284C>T	c.(3283-3285)cCa>cTa	p.P1095L		NM_000553.4	NP_000544.2	Q14191	WRN_HUMAN	Werner syndrome, RecQ helicase-like	1095					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(13)|lung(28)|ovary(3)|skin(3)|upper_aerodigestive_tract(3)	60		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		AATCAAGTACCAGTTGAATTA	0.239000			"""Mis, N, F, S"""			"""osteosarcoma, meningioma, others"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Werner syndrome				26	40					0	0	0.012213	0	0
OR4F6	390648	broad.mit.edu	37	15	102346044	102346044	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr15:102346044G>A	ENST00000328882.4	+	1	143	c.122G>A	c.(121-123)gGa>gAa	p.G41E		NM_001005326.1	NP_001005326.1	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F, member 6	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(1)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			AGCCTGATGGGAAATCTCCTC	0.483000													109	150					0	0	0.014410	0	0
OR51B2	79345	broad.mit.edu	37	11	5345040	5345040	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr11:5345040G>A	ENST00000328813.2	-	1	542	c.488C>T	c.(487-489)tCa>tTa	p.S163L	HBG2_ENST00000380259.2_Intron|HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron	NM_033180.4	NP_149420.4	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B, member 2	163					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|large_intestine(6)|lung(21)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATATGAAAATGAAAAAAGACG	0.398000													27	27					0	0	0.027356	0	0
C16orf78	123970	broad.mit.edu	37	16	49430546	49430546	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr16:49430546G>A	ENST00000299191.3	+	4	724	c.607G>A	c.(607-609)Gaa>Aaa	p.E203K		NM_144602.2	NP_653203.1	Q8WTQ4	CP078_HUMAN	chromosome 16 open reading frame 78	203										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|upper_aerodigestive_tract(1)	22						ACCTAAGATGGAAACCATGAG	0.552000													16	24					0	0	0.004990	0	0
ARMC5	79798	broad.mit.edu	37	16	31476161	31476161	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr16:31476161C>T	ENST00000457010.2	+	4	2518	c.1817C>T	c.(1816-1818)cCg>cTg	p.P606L	ARMC5_ENST00000268314.4_Missense_Mutation_p.P606L|ARMC5_ENST00000408912.3_Missense_Mutation_p.P701L|ARMC5_ENST00000538189.1_Missense_Mutation_p.P638L|ARMC5_ENST00000412665.2_Missense_Mutation_p.P250L|ARMC5_ENST00000563544.1_Missense_Mutation_p.P606L	NM_024742.2	NP_079018.1	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5	606							binding			central_nervous_system(1)|endometrium(4)|large_intestine(3)|liver(2)|lung(12)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						GACGATTGGCCGGCACCACGT	0.701000													11	11					0	0	0.016723	0	0
ZSWIM5	57643	broad.mit.edu	37	1	45484195	45484195	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr1:45484195G>A	ENST00000359600.5	-	14	3694	c.3489C>T	c.(3487-3489)atC>atT	p.I1163I		NM_020883.1	NP_065934.1	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM-type containing 5	1163							zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|liver(1)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	28	Acute lymphoblastic leukemia(166;0.155)					TGAGGTTGTCGATGAACTGGG	0.537000											OREG0013450	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	82	121					0	0	0.014410	0	0
RDH16	8608	broad.mit.edu	37	12	57348854	57348854	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr12:57348854C>T	ENST00000398138.3	-	2	1264	c.408G>A	c.(406-408)gtG>gtA	p.V136V	RDH16_ENST00000360752.4_Intron	NM_003708.3	NP_003699.3	O75452	RDH16_HUMAN	retinol dehydrogenase 16 (all-trans)	136					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	binding|electron carrier activity|retinol dehydrogenase activity			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)	16						CCAACAAGTTCACGTCCAGTA	0.587000													33	35					0	0	0.013726	0	0
FSIP2	401024	broad.mit.edu	37	2	186670597	186670597	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr2:186670597G>A	ENST00000343098.5	+	17	16831	c.16831G>A	c.(16831-16833)Gaa>Aaa	p.E5611K	FSIP2_ENST00000424728.1_Missense_Mutation_p.E5522K	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						GGAAGTGGATGAAAATAAAGT	0.343000													29	12					0	0	0.007291	0	0
SPTA1	6708	broad.mit.edu	37	1	158596698	158596698	+	Silent	SNP	A	A	G			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr1:158596698A>G	ENST00000368148.3	-	41	5944	c.5764T>C	c.(5764-5766)Ttg>Ctg	p.L1922L	SPTA1_ENST00000461624.1_5'UTR|SPTA1_ENST00000368147.3_Silent_p.L1919L	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1922					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TCCAATTGCAACTTCCAAGCA	0.468000													70	119					0	0	0.014410	0	0
TUBB8	347688	broad.mit.edu	37	10	93359	93359	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr10:93359C>T	ENST00000447903.2	-	4	1072	c.757G>A	c.(757-759)Gag>Aag	p.E253K	TUBB8_ENST00000309812.4_Missense_Mutation_p.E325K			Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 class VIII	325					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			NS(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(12)|ovary(2)|prostate(3)|skin(3)|stomach(1)	32		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		TCATCCACCTCCCTCATGGGC	0.522000													48	86					0	0	0.013114	0	0
GPR4	2828	broad.mit.edu	37	19	46094942	46094942	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr19:46094942G>A	ENST00000323040.4	-	2	1127	c.183C>T	c.(181-183)atC>atT	p.I61I	OPA3_ENST00000544371.1_Intron	NM_005282.2	NP_005273.1	P46093	GPR4_HUMAN	G protein-coupled receptor 4	61						integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		GCAGGTCGGCGATGCTGAGGT	0.647000													30	47					0	0	0.009535	0	0
CRMP1	1400	broad.mit.edu	37	4	5843034	5843034	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr4:5843034C>T	ENST00000324989.7	-	8	1242		c.e8+1		CRMP1_ENST00000511535.1_Splice_Site|CRMP1_ENST00000397890.2_Splice_Site|CRMP1_ENST00000512574.1_Splice_Site	NM_001014809.1	NP_001014809.1	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1						axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			NS(1)|cervix(2)|endometrium(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36				Colorectal(103;0.0721)		CGGCTGCATACCTTTCTTCCT	0.627000													90	123					0	0	0.014410	0	0
C10orf71	118461	broad.mit.edu	37	10	50532573	50532573	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr10:50532573G>A	ENST00000374144.3	+	3	2271	c.1983G>A	c.(1981-1983)gaG>gaA	p.E661E	C10orf71_ENST00000323868.4_Silent_p.E661E			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	661										endometrium(1)	1						GGGCTACAGAGAAAATGAAGA	0.552000													7	16					0	0	0.001984	0	0
CDC14A	8556	broad.mit.edu	37	1	100949997	100949997	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr1:100949997G>A	ENST00000336454.3	+	11	1482	c.1127G>A	c.(1126-1128)cGa>cAa	p.R376Q	CDC14A_ENST00000370125.2_3'UTR|RP5-837M10.4_ENST00000432210.1_RNA|CDC14A_ENST00000544534.1_Missense_Mutation_p.R376Q|CDC14A_ENST00000542213.1_Missense_Mutation_p.R318Q|CDC14A_ENST00000361544.6_Missense_Mutation_p.R376Q|CDC14A_ENST00000370124.3_Missense_Mutation_p.R376Q	NM_003672.3	NP_003663.2	Q9UNH5	CC14A_HUMAN	cell division cycle 14A	376					cell cycle|cell division|cell proliferation	centrosome|nucleus|spindle	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R376Q(1)		breast(1)|endometrium(5)|kidney(6)|large_intestine(6)|lung(10)|skin(2)|urinary_tract(1)	31		all_epithelial(167;3.71e-06)|all_lung(203;0.00097)|Lung NSC(277;0.001)		Epithelial(280;0.0676)|all cancers(265;0.127)|COAD - Colon adenocarcinoma(174;0.201)|Lung(183;0.227)|Colorectal(144;0.241)		AACATGGAACGATTTGGAGAG	0.343000													18	31					0	0	0.007413	0	0
ARHGAP11A	9824	broad.mit.edu	37	15	32929996	32929996	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr15:32929996C>T	ENST00000361627.3	+	12	3744	c.3022C>T	c.(3022-3024)Cct>Tct	p.P1008S	ARHGAP11A_ENST00000565905.1_Missense_Mutation_p.P819S|ARHGAP11A_ENST00000543522.1_Missense_Mutation_p.P819S	NM_014783.3	NP_055598.1	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A	1008					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		TCCAAAACATCCTATCGGAAA	0.353000													11	15					0	0	0.008291	0	0
FUT9	10690	broad.mit.edu	37	6	96651941	96651941	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr6:96651941G>A	ENST00000302103.5	+	3	1236	c.910G>A	c.(910-912)Gaa>Aaa	p.E304K		NM_006581.3	NP_006572.2	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3) fucosyltransferase)	304					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	34		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		GTATCTGAAGGAAGTCGACAA	0.378000													19	62					0	0	0.006122	0	0
ZNF227	7770	broad.mit.edu	37	19	44739804	44739804	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr19:44739804C>T	ENST00000313040.7	+	6	1426	c.1221C>T	c.(1219-1221)ccC>ccT	p.P407P	ZNF227_ENST00000589005.1_Silent_p.P356P|ZNF227_ENST00000391961.2_Silent_p.P356P	NM_182490.1	NP_872296.1	Q86WZ6	ZN227_HUMAN	zinc finger protein 227	407					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(12)|ovary(2)|stomach(1)|urinary_tract(1)	24		Prostate(69;0.0435)				GTGAGAAGCCCTATAAATGTG	0.478000													28	29					0	0	0.027356	0	0
TRABD2A	129293	broad.mit.edu	37	2	85051283	85051283	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr2:85051283G>A	ENST00000335459.5	-	5	1186	c.981C>T	c.(979-981)atC>atT	p.I327I	TRABD2A_ENST00000409520.2_Silent_p.I376I|TRABD2A_ENST00000479944.1_5'UTR	NM_001080824.1	NP_001074293.1			TraB domain containing 2A									p.I327M(1)|p.I376M(1)									TTGGAGCAAAGATGGTGGACA	0.582000													19	4					0	0	0.008871	0	0
PCDHB6	56130	broad.mit.edu	37	5	140531680	140531680	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr5:140531680C>T	ENST00000231136.1	+	1	1842	c.1842C>T	c.(1840-1842)ggC>ggT	p.G614G	PCDHB6_ENST00000543635.1_Silent_p.G478G	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		614	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTCTGTTCGGCGTGTGGGCGC	0.667000													4	40					0	0	0.003080	0	0
TRIM3	10612	broad.mit.edu	37	11	6477849	6477849	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr11:6477849C>T	ENST00000525074.1	-	6	1501	c.1107G>A	c.(1105-1107)ccG>ccA	p.P369P	TRIM3_ENST00000529058.1_5'UTR|TRIM3_ENST00000345851.3_Silent_p.P369P|TRIM3_ENST00000537602.1_Silent_p.P291P|TRIM3_ENST00000536344.1_Silent_p.P250P|TRIM3_ENST00000359518.3_Silent_p.P369P	NM_001248006.1	NP_001234935.1	O75382	TRIM3_HUMAN	tripartite motif containing 3	369					nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(3)	27		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCGTGCCGTCCGGGCCGGTGA	0.642000													33	27					0	0	0.017118	0	0
H2BFWT	158983	broad.mit.edu	37	X	103268042	103268042	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chrX:103268042C>T	ENST00000217926.5	-	1	217	c.191G>A	c.(190-192)cGa>cAa	p.R64Q		NM_001002916.3	NP_001002916.2	Q7Z2G1	H2BWT_HUMAN	H2B histone family, member W, testis-specific	64					nucleosome assembly	nuclear membrane|nucleosome	DNA binding			breast(2)|endometrium(3)|large_intestine(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	16						ATGGCGCCCTCGCTTCCTCTG	0.637000													22	5					0	0	0.014323	0	0
IGSF10	285313	broad.mit.edu	37	3	151165385	151165385	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr3:151165385T>G	ENST00000282466.3	-	4	2383	c.2384A>C	c.(2383-2385)gAt>gCt	p.D795A		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	795			D -> N (in dbSNP:rs58583961).		cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCCTGAGGAATCGTCTTCTTC	0.488000													30	58					0	0	0.008361	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70714144	70714144	+	RNA	SNP	A	A	G	rs111296958	by1000genomes	TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr14:70714144A>G	ENST00000530196.1	-	0	374					NR_003951.1																						AGAGCTTCTTAACCCTCATAT	0.502000													5	83					0	0	0.014758	0	0
TXK	7294	broad.mit.edu	37	4	48078475	48078475	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr4:48078475C>T	ENST00000264316.4	-	12	1267	c.1182G>A	c.(1180-1182)agG>agA	p.R394R	TXK_ENST00000507351.1_Silent_p.R49R	NM_003328.2	NP_003319.2	P42681	TXK_HUMAN	TXK tyrosine kinase	394	Protein kinase.					cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|prostate(2)	25						CCAAACAATTCCTTGCCGCCT	0.333000													32	37					0	0	0.019004	0	0
LRP3	4037	broad.mit.edu	37	19	33695571	33695571	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr19:33695571C>T	ENST00000253193.7	+	4	490	c.288C>T	c.(286-288)tcC>tcT	p.S96S	LRP3_ENST00000592484.1_3'UTR	NM_002333.3	NP_002324.2	O75074	LRP3_HUMAN	low density lipoprotein receptor-related protein 3	96	CUB 1.				receptor-mediated endocytosis	coated pit|integral to membrane	receptor activity			breast(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)	15	Esophageal squamous(110;0.137)					TGGAGGAGTCCCACCAGTGCT	0.672000													48	68					0	0	0.014410	0	0
SGOL2	151246	broad.mit.edu	37	2	201438005	201438005	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr2:201438005C>T	ENST00000357799.4	+	7	3034	c.2936C>T	c.(2935-2937)tCc>tTc	p.S979F		NM_001160033.1|NM_001160046.1|NM_152524.5	NP_001153505.1|NP_001153518.1|NP_689737.4	Q562F6	SGOL2_HUMAN	shugoshin-like 2 (S. pombe)	979					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			NS(2)|breast(2)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	46						ATTTTAGATTCCTACAAAGTA	0.294000													26	8					0	0	0.018920	0	0
PDE2A	5138	broad.mit.edu	37	11	72297156	72297156	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr11:72297156G>A	ENST00000334456.5	-	14	1385	c.1140C>T	c.(1138-1140)acC>acT	p.T380T	PDE2A_ENST00000544570.1_Silent_p.T373T|PDE2A_ENST00000418754.2_Silent_p.T265T|RP11-169D4.2_ENST00000545254.1_RNA|PDE2A_ENST00000540345.1_Silent_p.T371T|PDE2A_ENST00000376450.3_Silent_p.T124T|PDE2A_ENST00000444035.2_Silent_p.T371T	NM_002599.4	NP_002590.1	O00408	PDE2A_HUMAN	phosphodiesterase 2A, cGMP-stimulated	380					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	36			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	GGAAGGCCAGGGTGCTGGTGA	0.607000											OREG0021196	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	46	181					0	0	0.014410	0	0
NBEA	26960	broad.mit.edu	37	13	35747690	35747690	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr13:35747690C>T	ENST00000540320.1	+	27	5047	c.4513C>T	c.(4513-4515)Cag>Tag	p.Q1505*	NBEA_ENST00000379939.2_Nonsense_Mutation_p.Q1502*|NBEA_ENST00000310336.4_Nonsense_Mutation_p.Q1505*|NBEA_ENST00000400445.3_Nonsense_Mutation_p.Q1505*			Q8NFP9	NBEA_HUMAN	neurobeachin	1505						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		CAGTAAACCTCAGGAAGTTCC	0.358000													8	42					0	0	0.010729	0	0
LOC645752	645752	broad.mit.edu	37	15	78208916	78208916	+	RNA	SNP	C	C	G	rs56290535	by1000genomes	TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr15:78208916C>G	ENST00000565869.1	+	0	53																											TCCAGATGTTCTCCTCCATCT	0.627000													4	66					0	0	0.014758	0	0
SLC28A2	9153	broad.mit.edu	37	15	45561731	45561731	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr15:45561731T>A	ENST00000347644.3	+	14	1629	c.1564T>A	c.(1564-1566)Tct>Act	p.S522T	CTD-2651B20.3_ENST00000560344.1_RNA|CTD-2651B20.3_ENST00000561404.1_RNA	NM_004212.3	NP_004203.2	O43868	S28A2_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 2	522					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding|nucleoside:sodium symporter activity|purine nucleoside transmembrane transporter activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(4)|skin(1)	26		all_cancers(109;8.53e-07)|all_epithelial(112;1.39e-05)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.77e-16)|GBM - Glioblastoma multiforme(94;2.71e-06)		ACAGTGGATTTCTGTAAGTGA	0.438000													17	17					0	0	0.028581	0	0
PDZRN4	29951	broad.mit.edu	37	12	41949548	41949548	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr12:41949548G>A	ENST00000298919.7	+	7	959	c.571G>A	c.(571-573)Gat>Aat	p.D191N	PDZRN4_ENST00000539469.2_Missense_Mutation_p.D193N|PDZRN4_ENST00000402685.2_Missense_Mutation_p.D451N			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	451							ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TCGAGAAGGGGATCGGATTTT	0.408000													34	47					0	0	0.025465	0	0
FRMPD1	22844	broad.mit.edu	37	9	37708479	37708479	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr9:37708479C>T	ENST00000539465.1	+	4	936	c.343C>T	c.(343-345)Cga>Tga	p.R115*	FRMPD1_ENST00000377765.3_Nonsense_Mutation_p.R115*|RP11-613M10.9_ENST00000540557.1_Intron			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	115	PDZ.					cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		TTCCTGGGAACGAGCAGTCGA	0.448000													12	110					0	0	0.010729	0	0
TTN	7273	broad.mit.edu	37	2	179431635	179431635	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr2:179431635G>A	ENST00000589042.1	-	326	79448	c.79224C>T	c.(79222-79224)aaC>aaT	p.N26408N	TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Silent_p.N17468N|TTN_ENST00000342992.6_Silent_p.N23840N|TTN_ENST00000342175.6_Silent_p.N17535N|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.N17343N|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Silent_p.N24767N|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	24767	Ig-like 127.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATCTGGACGGTTCCAACAGA	0.413000													45	17					0	0	0.011902	0	0
OR6B3	150681	broad.mit.edu	37	2	240984604	240984604	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr2:240984604C>T	ENST00000319423.4	-	1	885	c.886G>A	c.(886-888)Gaa>Aaa	p.E296K		NM_173351.1	NP_775486.1	Q8NGW1	OR6B3_HUMAN	olfactory receptor, family 6, subfamily B, member 3	296					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(10)|lung(4)|ovary(2)|prostate(1)	18		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;1.05e-29)|all cancers(36;3.52e-28)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)|Colorectal(34;0.019)|COAD - Colon adenocarcinoma(134;0.141)		TTCTTAAATTCCTTATTCCTC	0.478000													92	25					0	0	0.014410	0	0
CACNA1E	777	broad.mit.edu	37	1	181765865	181765865	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr1:181765865G>A	ENST00000526775.1	+	45	6249	c.6084G>A	c.(6082-6084)aaG>aaA	p.K2028K	CACNA1E_ENST00000367570.1_Silent_p.K2047K|CACNA1E_ENST00000367573.2_Silent_p.K2090K|CACNA1E_ENST00000357570.5_Silent_p.K2041K|CACNA1E_ENST00000358338.5_Silent_p.K1979K|CACNA1E_ENST00000360108.3_Silent_p.K2071K|CACNA1E_ENST00000367567.4_Silent_p.K1654K	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	2090					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						AAGAGCGAAAGCATCTTCTCT	0.572000													16	16					0	0	0.004990	0	0
KMT2A	4297	broad.mit.edu	37	11	118376065	118376065	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr11:118376065G>A	ENST00000534358.1	+	27	9481	c.9458G>A	c.(9457-9459)aGc>aAc	p.S3153N	KMT2A_ENST00000389506.5_Missense_Mutation_p.S3150N|KMT2A_ENST00000354520.4_Missense_Mutation_p.S3112N	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		CCTTCTGCTAGCAAAGGATTG	0.473000													168	17					0	0	0.014410	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156909492	156909492	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr1:156909492G>C	ENST00000368194.3	-	37	4983	c.3944C>G	c.(3943-3945)cCa>cGa	p.P1315R	ARHGEF11_ENST00000361409.2_Missense_Mutation_p.P1275R|ARHGEF11_ENST00000487682.1_5'UTR|ARHGEF11_ENST00000315174.8_Missense_Mutation_p.P691R	NM_198236.2	NP_937879.1	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	1275					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(27)|ovary(4)|pancreas(2)|pleura(1)|prostate(4)|skin(7)|stomach(1)|urinary_tract(2)	81	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TTCCTGCTCTGGCCGTTCCCC	0.612000													25	15					0	0	0.021523	0	0
MARCH11	441061	broad.mit.edu	37	5	16067654	16067654	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr5:16067654G>A	ENST00000332432.8	-	4	1334	c.1135C>T	c.(1135-1137)Cgg>Tgg	p.R379W		NM_001102562.1	NP_001096032.1	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	379						cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(14)|urinary_tract(1)	20						GGCCTCATCCGATTGAACAGG	0.478000													74	97					0	0	0.014410	0	0
GPR137C	283554	broad.mit.edu	37	14	53066835	53066835	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr14:53066835C>T	ENST00000321662.6	+	3	493	c.493C>T	c.(493-495)Cta>Tta	p.L165L		NM_001099652.1	NP_001093122.1	Q8N3F9	G137C_HUMAN	G protein-coupled receptor 137C	165						integral to membrane				NS(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	8	Breast(41;0.0716)					TTTCAGAATTCTACTGCATTT	0.333000													44	45					0	0	0.011902	0	0
OR2Z1	284383	broad.mit.edu	37	19	8842008	8842008	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr19:8842008C>T	ENST00000324060.2	+	1	693	c.618C>T	c.(616-618)atC>atT	p.I206I		NM_001004699.1	NP_001004699.1	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z, member 1	206					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						GGGTGCTGATCCTAATGCTCC	0.572000													38	52					0	0	0.021022	0	0
LRP1B	53353	broad.mit.edu	37	2	140995774	140995774	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr2:140995774C>T	ENST00000389484.3	-	89	14478	c.13507G>A	c.(13507-13509)Gat>Aat	p.D4503N		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4503					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCGTTGTGATCATGATCTACC	0.353000										TSP Lung(27;0.18)			26	11					0	0	0.007291	0	0
PCDHB11	56125	broad.mit.edu	37	5	140579467	140579467	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr5:140579467G>A	ENST00000354757.3	+	1	120	c.120G>A	c.(118-120)caG>caA	p.Q40Q	PCDHB11_ENST00000536699.1_Intron	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		40	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAGAAATGCAGAGCGGGAGTT	0.527000													35	64					0	0	0.015359	0	0
ITIH1	3697	broad.mit.edu	37	3	52825798	52825798	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr3:52825798G>A	ENST00000273283.2	+	22	2631	c.2606_splice	c.e22-1	p.R869_splice	ITIH1_ENST00000542827.1_3'UTR|ITIH1_ENST00000540715.1_Splice_Site_p.R727_splice|ITIH1_ENST00000405128.3_Splice_Site_p.R235_splice|ITIH1_ENST00000537050.1_Splice_Site_p.R581_splice	NM_002215.3	NP_002206.2	P19827	ITIH1_HUMAN	inter-alpha-trypsin inhibitor heavy chain 1	869	Hyaluronan-binding.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(16)|lung(18)|ovary(4)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	52				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		CTCTGCACAGGGGTTTGCAAA	0.587000													9	21					0	0	0.004482	0	0
WIF1	11197	broad.mit.edu	37	12	65461507	65461507	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr12:65461507G>A	ENST00000286574.4	-	5	976	c.602C>T	c.(601-603)cCt>cTt	p.P201L		NM_007191.4	NP_009122.2	Q9Y5W5	WIF1_HUMAN	WNT inhibitory factor 1	201	EGF-like 1.				multicellular organismal development|Wnt receptor signaling pathway	extracellular region	protein tyrosine kinase activity			cervix(1)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|stomach(1)|urinary_tract(1)	21			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0231)		GAACCCATCAGGACACTCGCA	0.522000			T	HMGA2	pleomorphic salivary gland adenoma								11	28					0	0	0.016723	0	0
MEGF8	1954	broad.mit.edu	37	19	42880268	42880268	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr19:42880268G>A	ENST00000334370.4	+	41	8313	c.7678G>A	c.(7678-7680)Gcc>Acc	p.A2560T	MEGF8_ENST00000378073.4_Missense_Mutation_p.A221T|MEGF8_ENST00000251268.6_Missense_Mutation_p.A2627T	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2627	Pro-rich.					integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				TGGGCCCGGCGCCAACGGCTC	0.627000													11	21					0	0	0.008291	0	0
PCDHA6	56142	broad.mit.edu	37	5	140209955	140209955	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr5:140209955C>T	ENST00000529310.1	+	1	2393	c.2279C>T	c.(2278-2280)tCc>tTc	p.S760F	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGGTGTGCTCCGGGGAGGGC	0.612000													23	33					0	0	0.016522	0	0
BASP1	10409	broad.mit.edu	37	5	17275459	17275459	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr5:17275459C>T	ENST00000322611.3	+	2	394	c.134C>T	c.(133-135)gCc>gTc	p.A45V		NM_001271606.1|NM_006317.3	NP_001258535.1|NP_006308.3	P80723	BASP1_HUMAN	brain abundant, membrane attached signal protein 1	45				A -> P (in Ref. 1; AAC67374).	glomerular visceral epithelial cell differentiation|negative regulation of transcription, DNA-dependent	cytoplasm|cytoskeleton|growth cone|nuclear speck|plasma membrane	protein domain specific binding|transcription corepressor activity|transcription regulatory region DNA binding			endometrium(1)|lung(8)	9						CCCCAGGCGGCCGCAGAGCCC	0.677000													4	6					0	0	0.009096	0	0
TAAR5	9038	broad.mit.edu	37	6	132910108	132910108	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr6:132910108G>A	ENST00000258034.2	-	1	769	c.718C>T	c.(718-720)Ctg>Ttg	p.L240L		NM_003967.2	NP_003958.2	O14804	TAAR5_HUMAN	trace amine associated receptor 5	240					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	32	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00604)|GBM - Glioblastoma multiforme(226;0.015)		GCCCCAGCCAGGCTTTTGCTC	0.502000													26	12					0	0	0.024334	0	0
SLC9C2	284525	broad.mit.edu	37	1	173552686	173552686	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr1:173552686C>T	ENST00000367714.3	-	6	1021	c.599G>A	c.(598-600)gGa>gAa	p.G200E	SLC9C2_ENST00000536496.1_Missense_Mutation_p.G98E|RP3-436N22.3_ENST00000431459.1_RNA	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	200					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										CCGAAAATTTCCAAAAAAAAT	0.279000													27	33					0	0	0.021523	0	0
LAYN	143903	broad.mit.edu	37	11	111426015	111426015	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr11:111426015G>A	ENST00000436913.2	+	4	624	c.223_splice	c.e4+1	p.E75_splice	LAYN_ENST00000528924.1_3'UTR|LAYN_ENST00000533265.1_Splice_Site_p.E220_splice|LAYN_ENST00000525126.1_Splice_Site_p.E228_splice|LAYN_ENST00000375614.2_Splice_Site_p.E220_splice|LAYN_ENST00000375615.3_Splice_Site_p.E228_splice	NM_001258391.1	NP_001245320.1	Q6UX15	LAYN_HUMAN	layilin	228	C-type lectin.					cell surface|integral to membrane|ruffle	hyaluronic acid binding|sugar binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(3)|skin(1)	14		all_cancers(61;9.06e-10)|all_epithelial(67;1.34e-05)|Melanoma(852;1.74e-05)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.086)		Epithelial(105;1.5e-06)|BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|all cancers(92;2.45e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0476)		AGAAAGTAGAGGTATCTACAA	0.413000													8	19					0	0	0.004482	0	0
PTPRC	5788	broad.mit.edu	37	1	198682180	198682180	+	Missense_Mutation	SNP	C	C	T	rs142046206		TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr1:198682180C>T	ENST00000367376.2	+	12	1435	c.1264C>T	c.(1264-1266)Ctc>Ttc	p.L422F	PTPRC_ENST00000348564.6_Missense_Mutation_p.L263F|PTPRC_ENST00000594404.1_Missense_Mutation_p.L261F|PTPRC_ENST00000352140.3_Missense_Mutation_p.L374F|PTPRC_ENST00000442510.2_Missense_Mutation_p.L424F	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	422	Fibronectin type-III 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						TAATTTTACCCTCTGTTATAT	0.333000													19	63					0	0	0.012319	0	0
COL5A1	1289	broad.mit.edu	37	9	137622145	137622145	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr9:137622145G>A	ENST00000371817.3	+	7	1402	c.988G>A	c.(988-990)Gaa>Aaa	p.E330K		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	330	Nonhelical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GGCTGGGAAGGAAGAGGACGT	0.617000													39	18					0	0	0.023175	0	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													6	53					0	0	0.001984	0	0
PCDHA1	56147	broad.mit.edu	37	5	140166149	140166149	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr5:140166149C>A	ENST00000504120.2	+	1	274	c.274C>A	c.(274-276)Cgc>Agc	p.R92S	PCDHA1_ENST00000394633.3_Missense_Mutation_p.R92S|PCDHA1_ENST00000378133.3_Missense_Mutation_p.R92S	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGGATCGATCGCGAGGAGCT	0.567000													57	63					3.76628e-20	5.59427e-20	0.014410	1	0
BMP2K	55589	broad.mit.edu	37	4	79768397	79768397	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr4:79768397C>T	ENST00000335016.5	+	6	890	c.724C>T	c.(724-726)Ccc>Tcc	p.P242S	BMP2K_ENST00000502871.1_Missense_Mutation_p.P242S	NM_198892.1	NP_942595.1	Q9NSY1	BMP2K_HUMAN	BMP2 inducible kinase	242	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	13						TGGAGGGAAACCCATCACCAC	0.378000													21	12					0	0	0.018920	0	0
RNF217-AS1	7955	broad.mit.edu	37	6	125233728	125233728	+	RNA	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr6:125233728C>T	ENST00000439075.1	-	0	1017					NR_026876.1																						tcacgatattcccccaggtct	0.428000													2	0					0	0	0.004672	0	0
CSNK1D	1453	broad.mit.edu	37	17	80213335	80213335	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr17:80213335G>A	ENST00000314028.6	-	3	655	c.306C>T	c.(304-306)ctC>ctT	p.L102L	CSNK1D_ENST00000398519.5_Silent_p.L102L|CSNK1D_ENST00000392334.2_Silent_p.L102L|CSNK1D_ENST00000578904.1_5'UTR	NM_001893.4	NP_001884.2	P48730	KC1D_HUMAN	casein kinase 1, delta	102	Protein kinase.				circadian regulation of gene expression|DNA repair|G2/M transition of mitotic cell cycle|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|regulation of circadian rhythm|Wnt receptor signaling pathway	centrosome|cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|large_intestine(2)|lung(7)	11	Breast(20;0.00136)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0155)			GGACGGTTTTGAGGCTGAATT	0.542000													36	78					0	0	0.023175	0	0
LPPR1	54886	broad.mit.edu	37	9	104071546	104071546	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr9:104071546G>C	ENST00000374874.3	+	5	878	c.439G>C	c.(439-441)Gtg>Ctg	p.V147L	LPPR1_ENST00000395056.2_Missense_Mutation_p.V147L	NM_207299.1	NP_997182.1	Q8TBJ4	LPPR1_HUMAN		147						integral to membrane	catalytic activity										CGCCGGACAAGTGGTCACTGG	0.428000													34	14					0	0	0.015359	0	0
FAM131A	131408	broad.mit.edu	37	3	184059668	184059668	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr3:184059668T>G	ENST00000310585.4	+	1	1411	c.47T>G	c.(46-48)tTt>tGt	p.F16C	FAM131A_ENST00000383847.2_Intron|FAM131A_ENST00000453072.1_Intron|FAM131A_ENST00000418281.1_Intron|EIF2B5_ENST00000444495.1_Intron|FAM131A_ENST00000340957.5_Intron|FAM131A_ENST00000450976.1_Intron			Q6UXB0	F131A_HUMAN	family with sequence similarity 131, member A	16						extracellular region				breast(1)|endometrium(1)|large_intestine(2)|lung(9)|skin(1)	14	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GCACATCCCTTTGGAACTGTT	0.562000													75	106					0	0	0.014410	0	0
ABLIM3	22885	broad.mit.edu	37	5	148619383	148619383	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr5:148619383C>T	ENST00000506113.1	+	12	1618	c.1136C>T	c.(1135-1137)tCc>tTc	p.S379F	AC012613.2_ENST00000523176.1_RNA|RP11-331K21.1_ENST00000522685.1_RNA|ABLIM3_ENST00000356541.3_Missense_Mutation_p.S317F|ABLIM3_ENST00000309868.7_Missense_Mutation_p.S379F|ABLIM3_ENST00000508983.1_Missense_Mutation_p.S379F|ABLIM3_ENST00000504238.1_Missense_Mutation_p.S317F|ABLIM3_ENST00000326685.7_Missense_Mutation_p.S317F|ABLIM3_ENST00000519549.1_3'UTR|RP11-331K21.1_ENST00000512647.2_RNA			O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	379					axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACATAGACTCCCCCACCTAC	0.627000													36	56					0	0	0.021022	0	0
HEXIM2	124790	broad.mit.edu	37	17	43246477	43246477	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr17:43246477G>A	ENST00000307275.3	+	4	598	c.162G>A	c.(160-162)gaG>gaA	p.E54E	RP13-890H12.2_ENST00000589796.1_RNA|HEXIM2_ENST00000592695.1_Silent_p.E54E|HEXIM2_ENST00000591576.1_Silent_p.E54E	NM_144608.1	NP_653209.1	Q96MH2	HEXI2_HUMAN	hexamethylene bis-acetamide inducible 2	54					negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding			endometrium(1)|large_intestine(3)|lung(1)	5						GCCACTCAGAGGATGAAGATC	0.662000													65	104					0	0	0.014410	0	0
CYP2C9	1559	broad.mit.edu	37	10	96707648	96707648	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr10:96707648G>A	ENST00000260682.6	+	4	606	c.594G>A	c.(592-594)atG>atA	p.M198I		NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	198					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	TTAACTTAATGGAAAAGTTGA	0.378000													36	38					0	0	0.015359	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90161926	90161926	+	RNA	SNP	T	T	C	rs8061283	by1000genomes	TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr16:90161926T>C	ENST00000564451.1	+	0	1279				TUBB8P7_ENST00000567960.1_RNA														p.I221T(3)									CCCACACCCATCTATGGTGAC	0.527000													3	28					0	0	0.004672	0	0
TRERF1	55809	broad.mit.edu	37	6	42235936	42235936	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr6:42235936C>T	ENST00000541110.1	-	5	1961	c.1393G>A	c.(1393-1395)Ggg>Agg	p.G465R	TRERF1_ENST00000372917.4_Missense_Mutation_p.G465R|TRERF1_ENST00000372922.4_Missense_Mutation_p.G465R|TRERF1_ENST00000340840.2_Missense_Mutation_p.G465R|TRERF1_ENST00000354325.2_Missense_Mutation_p.G465R			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	465	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TGCTGAGGCCCCATGTTGTTG	0.602000													28	82					0	0	0.009535	0	0
CR2	1380	broad.mit.edu	37	1	207640026	207640026	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr1:207640026G>A	ENST00000367057.3	+	2	403	c.214G>A	c.(214-216)Gat>Aat	p.D72N	CR2_ENST00000367059.3_Missense_Mutation_p.D72N|CR2_ENST00000458541.2_Missense_Mutation_p.D72N|CR2_ENST00000367058.3_Missense_Mutation_p.D72N	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	72	Sushi 1.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						AGACAAAGTGGATGGAACCTG	0.413000													23	49					0	0	0.018920	0	0
XKR4	114786	broad.mit.edu	37	8	56270377	56270377	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr8:56270377C>T	ENST00000327381.5	+	2	1046	c.946C>T	c.(946-948)Cca>Tca	p.P316S		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	316						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			GGAAAGTGCTCCACAGCTGGT	0.468000													15	28					0	0	0.024245	0	0
GLRB	2743	broad.mit.edu	37	4	158057765	158057765	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr4:158057765G>A	ENST00000264428.4	+	5	712	c.442G>A	c.(442-444)Gaa>Aaa	p.E148K	GLRB_ENST00000509282.1_Missense_Mutation_p.E148K|GLRB_ENST00000541722.1_Missense_Mutation_p.E148K|GLRB_ENST00000512619.1_Intron	NM_000824.4	NP_000815.1	P48167	GLRB_HUMAN	glycine receptor, beta	148					nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(6)|skin(5)|upper_aerodigestive_tract(1)	27	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	TTTTGCAAATGAAAAAAGTGC	0.393000													48	75					0	0	0.014410	0	0
C4orf40	401137	broad.mit.edu	37	4	71024045	71024045	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr4:71024045G>A	ENST00000344526.5	+	3	265	c.75_splice	c.e3-1	p.D26_splice	C4orf40_ENST00000502441.2_Intron|C4orf40_ENST00000502294.1_Splice_Site_p.D26_splice	NM_214711.3	NP_999876.2	Q6MZM9	CD040_HUMAN	chromosome 4 open reading frame 40	26						extracellular region				breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						TCTCCTTTAGGATGACAATGA	0.358000													37	83					0	0	0.019004	0	0
DNAH5	1767	broad.mit.edu	37	5	13885323	13885323	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr5:13885323C>T	ENST00000265104.4	-	19	2862	c.2758G>A	c.(2758-2760)Gga>Aga	p.G920R	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	920	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TCAAAATTTCCTTCTTCTCTT	0.383000									Kartagener syndrome				11	30					0	0	0.010729	0	0
DEF8	54849	broad.mit.edu	37	16	90025426	90025426	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr16:90025426C>T	ENST00000563594.1	+	6	1374	c.377C>T	c.(376-378)cCc>cTc	p.P126L	DEF8_ENST00000563795.1_Missense_Mutation_p.P126L|DEF8_ENST00000563848.1_3'UTR|DEF8_ENST00000418391.2_Missense_Mutation_p.P126L|DEF8_ENST00000569453.1_Missense_Mutation_p.P126L|DEF8_ENST00000567874.1_Missense_Mutation_p.P66L|DEF8_ENST00000570182.1_Missense_Mutation_p.P116L|DEF8_ENST00000268676.7_Missense_Mutation_p.P187L	NM_001242818.1|NM_001242819.1	NP_001229747.1|NP_001229748.1	Q6ZN54	DEFI8_HUMAN	differentially expressed in FDCP 8 homolog (mouse)	187					intracellular signal transduction		zinc ion binding			central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	12		all_cancers(9;7.59e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.0019)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0274)		CTGCAGGACCCCAATGAGGAT	0.542000													28	89					0	0	0.008361	0	0
EPHX1	2052	broad.mit.edu	37	1	226019497	226019497	+	Silent	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr1:226019497C>T	ENST00000366837.4	+	3	397	c.201C>T	c.(199-201)atC>atT	p.I67I	EPHX1_ENST00000272167.5_Silent_p.I67I|EPHX1_ENST00000467015.1_3'UTR	NM_000120.3	NP_000111.1	P07099	HYEP_HUMAN	epoxide hydrolase 1, microsomal (xenobiotic)	67					aromatic compound catabolic process|response to toxin	endoplasmic reticulum membrane|integral to membrane|microsome	cis-stilbene-oxide hydrolase activity|epoxide hydrolase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(7)|ovary(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	28	Breast(184;0.197)					ACCAGAGGATCGATAAGTTCC	0.488000													27	42					0	0	0.006320	0	0
KSR2	283455	broad.mit.edu	37	12	118199251	118199251	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr12:118199251G>A	ENST00000425217.1	-	4	518	c.464C>T	c.(463-465)cCc>cTc	p.P155L	KSR2_ENST00000339824.5_Missense_Mutation_p.P184L	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	184					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGGCTCCGGGGGGCACACGGG	0.627000													34	49					0	0	0.015359	0	0
LRRC4C	57689	broad.mit.edu	37	11	40137497	40137497	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr11:40137497C>T	ENST00000278198.2	-	2	2309	c.346G>A	c.(346-348)Gaa>Aaa	p.E116K	LRRC4C_ENST00000530763.1_Missense_Mutation_p.E116K|LRRC4C_ENST00000528697.1_Missense_Mutation_p.E116K|LRRC4C_ENST00000527150.1_Missense_Mutation_p.E116K			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	116					regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				GCCCCAATTTCAATGGTTCTG	0.428000													23	33					0	0	0.012319	0	0
PER1	5187	broad.mit.edu	37	17	8053945	8053945	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr17:8053945G>A	ENST00000317276.4	-	2	317	c.80C>T	c.(79-81)tCc>tTc	p.S27F	PER1_ENST00000354903.5_Intron|PER1_ENST00000581082.1_Missense_Mutation_p.S27F	NM_002616.2	NP_002607.2	O15534	PER1_HUMAN	period circadian clock 1	27					circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(15)|ovary(4)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						GGGCCCAGGGGATGGGACGCC	0.647000			T	ETV6	"""AML, CMML"""			Other conserved DNA damage response genes					46	44					0	0	0.011902	0	0
RIMBP2	23504	broad.mit.edu	37	12	130926629	130926629	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr12:130926629G>A	ENST00000261655.4	-	8	1380	c.1217C>T	c.(1216-1218)tCc>tTc	p.S406F	RIMBP2_ENST00000535703.1_Missense_Mutation_p.S314F|RIMBP2_ENST00000536002.1_Missense_Mutation_p.S314F	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	406	Fibronectin type-III 2.					cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GAGCTGGGCGGAGATCTGCGT	0.622000													21	24					0	0	0.010504	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587576	43587576	+	RNA	SNP	A	A	G	rs145439557	by1000genomes	TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr17:43587576A>G	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							tctgaaaagaaaagaaaaaaa	0.428000													3	54					0	0	0.004672	0	0
TAAR5	9038	broad.mit.edu	37	6	132910109	132910109	+	Silent	SNP	G	G	A			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr6:132910109G>A	ENST00000258034.2	-	1	768	c.717C>T	c.(715-717)agC>agT	p.S239S		NM_003967.2	NP_003958.2	O14804	TAAR5_HUMAN	trace amine associated receptor 5	239					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	32	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00604)|GBM - Glioblastoma multiforme(226;0.015)		CCCCAGCCAGGCTTTTGCTCA	0.507000													26	12					0	0	0.024334	0	0
CYP4A22	284541	broad.mit.edu	37	1	47611598	47611601	+	Splice_Site	DEL	TAGA	TAGA	-	rs2405599	byFrequency	TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr1:47611598_47611601delTAGA	ENST00000371891.3	+	10	1314_1317	c.1287_splice	c.e10+1	p.LE428_splice	CYP4A22_ENST00000485117.1_3'UTR|CYP4A22_ENST00000294337.3_Splice_Site_p.LE428_splice|CYP4A22_ENST00000371890.3_Splice_Site_p.LE330_splice|CYP4A22-AS1_ENST00000444042.2_lincRNA	NM_001010969.2	NP_001010969.2	Q5TCH4	CP4AM_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 22	428			L -> P (in allele CYP4A22*6, allele CYP4A22*9, allele CYP4A22*10, allele CYP4A22*12, allele CYP4A22*13 and allele CYP4A22*15; dbSNP:rs2405599).			endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TGGCCCAACCTAGAGGTATGTGGT	0.510													105	209	---	---	---	---					
KRTCAP2	200185	broad.mit.edu	37	1	155145290	155145291	+	Frame_Shift_Ins	INS	-	-	G			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr1:155145290_155145291insG	ENST00000295682.4	-	2	190_191	c.160_161insC	c.(160-162)tcafs	p.S54fs	KRTCAP2_ENST00000490672.1_5'UTR	NM_173852.3	NP_776251.1	Q8N6L1	KTAP2_HUMAN	keratinocyte associated protein 2	54						integral to membrane				endometrium(2)|large_intestine(1)|lung(1)	4	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.18e-10)|all cancers(21;8.39e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GGCCAGCTGACGGCTGTACATC	0.639													32	27	---	---	---	---					
SFRP2	6423	broad.mit.edu	37	4	154709955	154709956	+	In_Frame_Ins	INS	-	-	AGC			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr4:154709955_154709956insAGC	ENST00000274063.4	-	1	316_317	c.32_33insGCT	c.(31-33)ctt>cGCTtt	p.11_11L>RF		NM_003013.2	NP_003004.1	Q96HF1	SFRP2_HUMAN	secreted frizzled-related protein 2	11					brain development|cardiac left ventricle morphogenesis|cell-cell signaling|dermatome development|hemopoietic stem cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|negative regulation of cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|outflow tract morphogenesis|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell adhesion mediated by integrin|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of fat cell differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of stem cell division|sclerotome development	cytoplasm|extracellular matrix|extracellular space|plasma membrane	fibronectin binding|integrin binding|PDZ domain binding|receptor agonist activity|Wnt receptor activity|Wnt-protein binding			breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(1)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	16	all_hematologic(180;0.093)	Renal(120;0.117)				AGGCGAGGAAGAGCAGCAGCAG	0.708													8	20	---	---	---	---					
INTS4P2	644619	broad.mit.edu	37	7	65150817	65150817	+	RNA	DEL	C	C	-			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr7:65150817delC	ENST00000430126.2	+	0	757																											TCATCCCTCACCCCCCCCCCC	0.468													3	6	---	---	---	---					
PSCA	8000	broad.mit.edu	37	8	143762824	143762824	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr8:143762824delG	ENST00000301258.4	+	2	188	c.105delG	c.(103-105)ctfs	p.L35fs	PSCA_ENST00000505305.1_3'UTR|PSCA_ENST00000513264.1_Frame_Shift_Del_p.L35fs	NM_005672.4	NP_005663.2	D3DWI6	D3DWI6_HUMAN	prostate stem cell antigen	35										endometrium(1)|large_intestine(1)	2	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					GCACCCAGCTGGGGGAGCAGT	0.632													13	8	---	---	---	---					
HRCT1	646962	broad.mit.edu	37	9	35906595	35906596	+	In_Frame_Ins	INS	-	-	CCC	rs58509439		TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr9:35906595_35906596insCCC	ENST00000354323.2	+	1	407_408	c.311_312insCCC	c.(310-312)cca>cCCCca	p.104_104P>PP		NM_001039792.1	NP_001034881.1	Q6UXD1	HRCT1_HUMAN	histidine rich carboxyl terminus 1	104	His-rich.					integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|prostate(1)	4						caccaccaccaccacccccacc	0.673													9	23	---	---	---	---					
RSPH6A	81492	broad.mit.edu	37	19	46299147	46299149	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-FS-A1YW-06A-11D-A197-08	TCGA-FS-A1YW-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ede8a2a-405e-4689-967b-627bff0f1496	781d7787-9f92-4774-ac27-6c679bbd3387	g.chr19:46299147_46299149delCCT	ENST00000221538.3	-	6	2274_2276	c.2132_2134delAGG	c.(2131-2136)ggc>g	p.EG711del	RSPH6A_ENST00000597055.1_3'UTR|RSPH6A_ENST00000600188.1_In_Frame_Del_p.EG447del	NM_030785.3	NP_110412.1	Q9H0K4	RSH6A_HUMAN	radial spoke head 6 homolog A (Chlamydomonas)	711	Glu-rich.					intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						GTctcctcgccctcctcctcctc	0.557													9	151	---	---	---	---					
