Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
CA6	765	broad.mit.edu	37	1	9009386	9009386	+	Silent	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr1:9009386G>A	uc001apm.2	+	2	168	c.144G>A	c.(142-144)TCG>TCA	p.S48S	CA6_uc009vmn.2_Intron	NM_001215	NP_001206	P23280	CAH6_HUMAN	carbonic anhydrase VI precursor	48					one-carbon metabolic process	extracellular region	carbonate dehydratase activity|zinc ion binding			ovary(2)	2	Ovarian(185;0.112)|all_lung(157;0.143)	all_epithelial(116;1.02e-19)|all_lung(118;3.6e-06)|Lung NSC(185;7.94e-06)|Renal(390;0.000147)|Breast(348;0.00123)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.9e-07)|COAD - Colon adenocarcinoma(227;8.28e-05)|Kidney(185;0.000268)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|STAD - Stomach adenocarcinoma(132;0.00184)|BRCA - Breast invasive adenocarcinoma(304;0.00192)|READ - Rectum adenocarcinoma(331;0.0649)		AGAGACAGTCGCCTATCAACC	0.592000												
HSPG2	3339	broad.mit.edu	37	1	22188576	22188576	+	Silent	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr1:22188576G>A	uc001bfj.2	-	38	4813	c.4773C>T	c.(4771-4773)TGC>TGT	p.C1591C	HSPG2_uc009vqd.2_Silent_p.C1592C	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	1591	Laminin EGF-like 10.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CACAAAGCTCGCAGAACTCCC	0.517000												
MYOM3	127294	broad.mit.edu	37	1	24418800	24418800	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr1:24418800C>T	uc001bin.3	-	11	1259	c.1096G>A	c.(1096-1098)GAG>AAG	p.E366K	MYOM3_uc001bim.3_Missense_Mutation_p.E23K|MYOM3_uc001bio.2_Missense_Mutation_p.E366K|MYOM3_uc001bip.1_Missense_Mutation_p.E23K	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	366										skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		TTCTCGGCCTCGGCATCTGAA	0.637000												
KLF17	128209	broad.mit.edu	37	1	44595138	44595138	+	Silent	SNP	A	A	C			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr1:44595138A>C	uc001clp.2	+	2	253	c.195A>C	c.(193-195)GCA>GCC	p.A65A	KLF17_uc009vxf.1_Silent_p.A28A	NM_173484	NP_775755	Q5JT82	KLF17_HUMAN	zinc finger protein 393	65					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					CTCACAGCGCAGAGATGCTGG	0.557000												
C8A	731	broad.mit.edu	37	1	57347266	57347266	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr1:57347266T>C	uc001cyo.2	+	5	745	c.613T>C	c.(613-615)TAC>CAC	p.Y205H		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	205	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						TGATGAGAAATACTTTCGGAA	0.488000												
LPHN2	23266	broad.mit.edu	37	1	82302724	82302724	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr1:82302724T>G	uc001dit.3	+	3	236	c.55T>G	c.(55-57)TTC>GTC	p.F19V	LPHN2_uc001dis.2_Missense_Mutation_p.F19V|LPHN2_uc001diu.2_Missense_Mutation_p.F19V|LPHN2_uc001div.2_Missense_Mutation_p.F19V|LPHN2_uc009wcd.2_Missense_Mutation_p.F19V	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	19					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TGTAATCAGCTTCTTACCAAA	0.328000												
WNT2B	7482	broad.mit.edu	37	1	113058897	113058897	+	Missense_Mutation	SNP	G	G	A	rs35058556	byFrequency	TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr1:113058897G>A	uc001ecb.2	+	3	1054	c.539G>A	c.(538-540)CGT>CAT	p.R180H	WNT2B_uc001eca.2_Missense_Mutation_p.R161H|WNT2B_uc009wgg.2_Missense_Mutation_p.R88H	NM_024494	NP_078613	Q93097	WNT2B_HUMAN	wingless-type MMTV integration site family,	180					chondrocyte differentiation|cornea development in camera-type eye|dorsal/ventral axis specification|forebrain regionalization|hemopoietic stem cell proliferation|iris morphogenesis|lens development in camera-type eye|lung induction|male gonad development|neuron differentiation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding|signal transducer activity			ovary(2)|breast(2)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;7.31e-07)|all_epithelial(167;4.59e-06)|all_lung(203;2.56e-05)|Lung NSC(69;4.38e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CATGACCAGCGTGGGGACTTT	0.587000												
FLG2	388698	broad.mit.edu	37	1	152327633	152327633	+	Missense_Mutation	SNP	T	T	A	rs144938115		TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr1:152327633T>A	uc001ezw.3	-	3	2702	c.2629A>T	c.(2629-2631)AGC>TGC	p.S877C	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	877	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGACCTGAGCTTGACCTGTGT	0.502000												
C1orf156	92342	broad.mit.edu	37	1	169762277	169762277	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr1:169762277G>A	uc001ggn.2	-	2	838	c.560C>T	c.(559-561)GCT>GTT	p.A187V	C1orf112_uc001ggj.2_Intron|C1orf112_uc001ggo.2_5'Flank|uc010plt.1_5'Flank|C1orf112_uc001ggp.2_5'Flank|C1orf112_uc001ggq.2_5'Flank|C1orf112_uc009wvt.2_5'Flank	NM_033418	NP_219486	O95568	MET18_HUMAN	hypothetical protein MGC9084	187						cytoplasm	protein methyltransferase activity				0	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TTTTTTCCCAGCAAATTTCAC	0.398000												
OBSCN	84033	broad.mit.edu	37	1	228437778	228437778	+	Silent	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr1:228437778G>A	uc009xez.1	+	14	4190	c.4146G>A	c.(4144-4146)ACG>ACA	p.T1382T	OBSCN_uc001hsn.2_Silent_p.T1382T	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1382	Ig-like 14.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CAGAGGTGACGTGGTACAAGG	0.642000												
SIPA1L2	57568	broad.mit.edu	37	1	232581434	232581434	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr1:232581434G>A	uc001hvg.2	-	9	3352	c.3194C>T	c.(3193-3195)ACG>ATG	p.T1065M	SIPA1L2_uc001hvf.2_Missense_Mutation_p.T139M	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1065					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CCGGTGCCACGTGGTGTTCCT	0.637000												
LGALS8	3964	broad.mit.edu	37	1	236708103	236708103	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr1:236708103A>T	uc001hxz.1	+	10	1073	c.692A>T	c.(691-693)AAC>ATC	p.N231I	LGALS8_uc001hxw.1_Missense_Mutation_p.N273I|LGALS8_uc001hxy.1_Missense_Mutation_p.N273I|LGALS8_uc009xgg.1_RNA|LGALS8_uc001hya.1_Missense_Mutation_p.N231I|LGALS8_uc001hyb.1_Missense_Mutation_p.N231I|LGALS8_uc001hyc.1_Missense_Mutation_p.N214I	NM_201543	NP_963837	O00214	LEG8_HUMAN	galectin-8 isoform b	231	Galectin 2.					cytoplasm|extracellular space	sugar binding			ovary(1)	1	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.0253)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			CTACACTTGAACCCACGCCTG	0.358000												
FMN2	56776	broad.mit.edu	37	1	240555838	240555838	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr1:240555838A>C	uc010pyd.1	+	15	5111	c.4886A>C	c.(4885-4887)AAT>ACT	p.N1629T	FMN2_uc010pye.1_Missense_Mutation_p.N1633T|FMN2_uc010pyf.1_Missense_Mutation_p.N244T|FMN2_uc010pyg.1_Missense_Mutation_p.N225T	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1629	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GCAGAGGAAAATTCACTGACA	0.343000												
OR2T12	127064	broad.mit.edu	37	1	248457994	248457994	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr1:248457994T>G	uc010pzj.1	-	1	887	c.887A>C	c.(886-888)AAG>ACG	p.K296T		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	296	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			CAGGGCTTCCTTGACCTCACT	0.473000												
OR2M7	391196	broad.mit.edu	37	1	248487429	248487429	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr1:248487429A>G	uc010pzk.1	-	1	442	c.442T>C	c.(442-444)TCC>CCC	p.S148P		NM_001004691	NP_001004691	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M,	148	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGGATCCAGGAGAAGGCAGTC	0.473000												
ZMYND11	10771	broad.mit.edu	37	10	288050	288050	+	Silent	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr10:288050C>T	uc010pzt.1	+	10	1349	c.921C>T	c.(919-921)GAC>GAT	p.D307D	ZMYND11_uc001ifk.2_Silent_p.D306D|ZMYND11_uc010pzu.1_Silent_p.D307D|ZMYND11_uc010pzv.1_Silent_p.D252D|ZMYND11_uc010pzw.1_Silent_p.D222D|ZMYND11_uc001ifm.2_Silent_p.D253D|ZMYND11_uc010pzx.1_Silent_p.D307D|ZMYND11_uc001ifn.2_Silent_p.D253D|ZMYND11_uc009xhg.2_Silent_p.D290D|ZMYND11_uc009xhh.2_Silent_p.D181D|ZMYND11_uc010pzy.1_Silent_p.D159D	NM_006624	NP_006615	Q15326	ZMY11_HUMAN	zinc finger, MYND domain containing 11 isoform	267	PWWP.				cell cycle|cell proliferation|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;1.32e-05)|all_lung(4;3.67e-05)|Lung NSC(4;0.000301)|all_epithelial(10;0.000416)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.132)	Epithelial(11;0.00289)|all cancers(11;0.0108)|Lung(33;0.0689)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		ATCAAGTCGACGTTCGCTTCT	0.428000												
WAPAL	23063	broad.mit.edu	37	10	88220968	88220968	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr10:88220968C>T	uc001kdo.2	-	10	2889	c.2447G>A	c.(2446-2448)CGG>CAG	p.R816Q	WAPAL_uc009xsv.2_Missense_Mutation_p.R130Q|WAPAL_uc001kdn.2_Missense_Mutation_p.R853Q|WAPAL_uc009xsw.2_Missense_Mutation_p.R810Q	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog	816	WAPL.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1						ACCCAAAAGCCGGAGTTCTTC	0.333000												
KIF20B	9585	broad.mit.edu	37	10	91533796	91533796	+	Silent	SNP	A	A	G			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr10:91533796A>G	uc001kgs.1	+	33	5526	c.5454A>G	c.(5452-5454)ACA>ACG	p.T1818T	KIF20B_uc001kgr.1_Silent_p.T1778T|KIF20B_uc001kgt.1_Silent_p.T1029T|KIF20B_uc009xtw.1_RNA	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	1818	Interaction with PIN1.				cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						GAACAAAAACAGCCAAATAAA	0.279000												
HECTD2	143279	broad.mit.edu	37	10	93250996	93250996	+	Missense_Mutation	SNP	G	G	A	rs149760758	byFrequency	TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr10:93250996G>A	uc001khl.2	+	12	1331	c.1231G>A	c.(1231-1233)GAT>AAT	p.D411N	LOC100188947_uc010qnl.1_Intron|HECTD2_uc010qnm.1_Missense_Mutation_p.D415N|HECTD2_uc001khm.2_RNA|HECTD2_uc009xty.1_5'UTR|HECTD2_uc001khn.1_Missense_Mutation_p.D61N	NM_182765	NP_877497	Q5U5R9	HECD2_HUMAN	HECT domain containing 2 isoform a	411					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			skin(1)	1						ACAGAGACCTGATATGAATAT	0.279000												
BTRC	8945	broad.mit.edu	37	10	103298091	103298091	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr10:103298091G>A	uc001kta.2	+	13	1732	c.1619G>A	c.(1618-1620)CGT>CAT	p.R540H	BTRC_uc001ktb.2_Missense_Mutation_p.R504H|BTRC_uc001ktc.2_Missense_Mutation_p.R514H	NM_033637	NP_378663	Q9Y297	FBW1A_HUMAN	beta-transducin repeat containing protein	540	WD 6.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|positive regulation of proteolysis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|viral reproduction|Wnt receptor signaling pathway	cytosol|nucleus|SCF ubiquitin ligase complex				ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;1.05e-08)|all cancers(201;6.59e-07)		TTGGACCCCCGTGCTCCTGCA	0.458000												
NELL1	4745	broad.mit.edu	37	11	21594908	21594908	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr11:21594908T>G	uc001mqe.2	+	19	2488	c.2335T>G	c.(2335-2337)TCA>GCA	p.S779A	NELL1_uc001mqf.2_Missense_Mutation_p.S732A|NELL1_uc009yid.2_Missense_Mutation_p.S807A|NELL1_uc010rdo.1_Missense_Mutation_p.S722A|NELL1_uc010rdp.1_Missense_Mutation_p.S492A|NELL1_uc001mqh.2_Missense_Mutation_p.S324A	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	779	VWFC 5.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						GCTTAGTGGCTCAGTGTGGAC	0.488000												
CCDC73	493860	broad.mit.edu	37	11	32632734	32632734	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr11:32632734C>T	uc001mtv.2	-	17	3018	c.2974G>A	c.(2974-2976)GAA>AAA	p.E992K		NM_001008391	NP_001008392	Q6ZRK6	CCD73_HUMAN	sarcoma antigen NY-SAR-79	992										ovary(1)|central_nervous_system(1)	2	Breast(20;0.112)					TTCTTCTCTTCACTGGGTTCT	0.398000												
OR4C13	283092	broad.mit.edu	37	11	49974468	49974468	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr11:49974468C>T	uc010rhz.1	+	1	494	c.494C>T	c.(493-495)CCT>CTT	p.P165L		NM_001001955	NP_001001955	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C,	165	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(1)	4						TGTCAATTACCTTTCTGTGGT	0.438000												
OR5D13	390142	broad.mit.edu	37	11	55541130	55541130	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr11:55541130T>G	uc010ril.1	+	1	217	c.217T>G	c.(217-219)TTC>GTC	p.F73V		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	73	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				CTTGACAGACTTCTGTTTTTC	0.393000												
C11orf9	745	broad.mit.edu	37	11	61539366	61539366	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr11:61539366T>C	uc001nsc.1	+	7	1153	c.1057T>C	c.(1057-1059)TGG>CGG	p.W353R	C11orf9_uc001nse.1_Missense_Mutation_p.W344R	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	353	NDT80.				central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						GTCCATCAAGTGGCAGCCTCA	0.617000												
AHNAK	79026	broad.mit.edu	37	11	62299903	62299903	+	Silent	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr11:62299903G>A	uc001ntl.2	-	5	2286	c.1986C>T	c.(1984-1986)CCC>CCT	p.P662P	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	662					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CATTGACCTTGGGCCCTGAAA	0.498000												
SLC22A6	9356	broad.mit.edu	37	11	62747361	62747361	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr11:62747361C>A	uc001nwk.2	-	7	1404	c.1097G>T	c.(1096-1098)AGC>ATC	p.S366I	SLC22A6_uc001nwl.2_Missense_Mutation_p.S366I|SLC22A6_uc001nwj.2_Missense_Mutation_p.S366I|SLC22A6_uc001nwm.2_Missense_Mutation_p.S366I	NM_004790	NP_004781	Q4U2R8	S22A6_HUMAN	solute carrier family 22 member 6 isoform a	366	Extracellular (Potential).				alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding				0						TAGGTAGATGCTGACTCCAAA	0.517000												
ZFPL1	7542	broad.mit.edu	37	11	64854058	64854058	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr11:64854058G>A	uc001ocq.1	+	4	551	c.386G>A	c.(385-387)CGG>CAG	p.R129Q	CDCA5_uc001ocp.2_5'Flank	NM_006782	NP_006773	O95159	ZFPL1_HUMAN	zinc finger protein-like 1	129	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|vesicle-mediated transport	Golgi apparatus|integral to membrane|nucleus	DNA binding|zinc ion binding			ovary(1)	1						AACTGGGCCCGGGCAGGACTG	0.647000												
C11orf2	738	broad.mit.edu	37	11	64875710	64875710	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr11:64875710A>G	uc001ocr.1	+	5	807	c.767A>G	c.(766-768)GAG>GGG	p.E256G	C11orf2_uc001ocs.1_Missense_Mutation_p.E132G	NM_013265	NP_037397	Q9UID3	FFR_HUMAN	chromosome 11 open reading frame 2	256					lipid transport|protein transport	Golgi apparatus|integral to membrane					0						GAGTGCGTGGAGCTGCTGCTG	0.726000												
SLC36A4	120103	broad.mit.edu	37	11	92918925	92918925	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr11:92918925A>T	uc001pdn.2	-	2	208	c.111T>A	c.(109-111)GAT>GAA	p.D37E	SLC36A4_uc001pdm.2_5'UTR	NM_152313	NP_689526	Q6YBV0	S36A4_HUMAN	solute carrier family 36 (proton/amino acid	37					L-alanine transport|proline transport|tryptophan transport	integral to membrane	symporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CATGTTCTTCATCTGATGTCC	0.353000												
GRIK4	2900	broad.mit.edu	37	11	120811160	120811160	+	Silent	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr11:120811160C>T	uc001pxn.2	+	14	1868	c.1581C>T	c.(1579-1581)CGC>CGT	p.R527R	GRIK4_uc009zav.1_Silent_p.R527R|GRIK4_uc009zaw.1_Silent_p.R527R|GRIK4_uc009zax.1_Silent_p.R527R	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	527	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	TTCTTTACCGCGTTCATATGG	0.393000												
CACNA1C	775	broad.mit.edu	37	12	2558239	2558239	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr12:2558239G>A	uc009zdu.1	+	4	888	c.575G>A	c.(574-576)CGC>CAC	p.R192H	CACNA1C_uc009zdv.1_Missense_Mutation_p.R192H|CACNA1C_uc001qkb.2_Missense_Mutation_p.R192H|CACNA1C_uc001qkc.2_Missense_Mutation_p.R192H|CACNA1C_uc001qke.2_Missense_Mutation_p.R192H|CACNA1C_uc001qkf.2_Missense_Mutation_p.R192H|CACNA1C_uc001qjz.2_Missense_Mutation_p.R192H|CACNA1C_uc001qkd.2_Missense_Mutation_p.R192H|CACNA1C_uc001qkg.2_Missense_Mutation_p.R192H|CACNA1C_uc009zdw.1_Missense_Mutation_p.R192H|CACNA1C_uc001qkh.2_Missense_Mutation_p.R192H|CACNA1C_uc001qkl.2_Missense_Mutation_p.R192H|CACNA1C_uc001qkn.2_Missense_Mutation_p.R192H|CACNA1C_uc001qko.2_Missense_Mutation_p.R192H|CACNA1C_uc001qkp.2_Missense_Mutation_p.R192H|CACNA1C_uc001qkr.2_Missense_Mutation_p.R192H|CACNA1C_uc001qku.2_Missense_Mutation_p.R192H|CACNA1C_uc001qkq.2_Missense_Mutation_p.R192H|CACNA1C_uc001qks.2_Missense_Mutation_p.R192H|CACNA1C_uc001qkt.2_Missense_Mutation_p.R192H|CACNA1C_uc001qka.1_5'UTR|CACNA1C_uc001qki.1_5'UTR|CACNA1C_uc001qkj.1_5'UTR|CACNA1C_uc001qkk.1_5'UTR|CACNA1C_uc001qkm.1_5'UTR	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	192	I.|Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GCCTACCTCCGCAACGGCTGG	0.378000												
RIMKLB	57494	broad.mit.edu	37	12	8926380	8926380	+	Nonstop_Mutation	SNP	A	A	C			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr12:8926380A>C	uc001quu.2	+	6	1412	c.1161A>C	c.(1159-1161)TGA>TGC	p.*387C	RIMKLB_uc009zgf.1_Intron|RIMKLB_uc001qux.2_Nonstop_Mutation_p.*387C|RIMKLB_uc010sgl.1_Nonstop_Mutation_p.*387C|RIMKLB_uc001quw.2_Intron	NM_020734	NP_065785	Q9ULI2	RIMKB_HUMAN	ribosomal modification protein rimK-like family	387					protein modification process	cytoplasm	acid-amino acid ligase activity|ATP binding|metal ion binding				0						TGGTGGACTGACTCCACTGGT	0.453000												
A2M	2	broad.mit.edu	37	12	9231877	9231877	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr12:9231877A>C	uc001qvk.1	-	25	3195	c.3082T>G	c.(3082-3084)TTT>GTT	p.F1028V	A2M_uc001qvj.1_Missense_Mutation_p.F70V|A2M_uc009zgk.1_Missense_Mutation_p.F878V	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	1028					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	CGCTCCCCAAAGGTGCTGTAG	0.343000												
SLCO1B3	28234	broad.mit.edu	37	12	21028196	21028196	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr12:21028196C>A	uc001rek.2	+	8	881	c.755C>A	c.(754-756)TCT>TAT	p.S252Y	SLCO1B3_uc001rel.2_Missense_Mutation_p.S252Y|SLCO1B3_uc010sil.1_Missense_Mutation_p.S252Y|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Missense_Mutation_p.S77Y	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	252	Extracellular (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					CCTAAGGACTCTCGTTGGGTT	0.368000												
SLCO1B3	28234	broad.mit.edu	37	12	21051412	21051412	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr12:21051412G>C	uc001rek.2	+	13	1851	c.1725G>C	c.(1723-1725)CAG>CAC	p.Q575H	SLCO1B3_uc001rel.2_Missense_Mutation_p.Q575H|SLCO1B3_uc010sil.1_Missense_Mutation_p.Q575H|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Missense_Mutation_p.Q400H	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	575	Helical; Name=11; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					TGGGTTTCCAGTCAATGGTTA	0.259000												
HELB	92797	broad.mit.edu	37	12	66725385	66725385	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr12:66725385G>T	uc001sti.2	+	12	3150	c.3122G>T	c.(3121-3123)TGT>TTT	p.C1041F	HELB_uc010ssz.1_RNA|HELB_uc009zqt.1_RNA	NM_033647	NP_387467	Q8NG08	HELB_HUMAN	helicase (DNA) B	1041					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			central_nervous_system(1)|pancreas(1)	2			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		AAAAGAACCTGTGGTGTGAAT	0.393000												
CLLU1OS	574016	broad.mit.edu	37	12	92814941	92814941	+	Silent	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr12:92814941G>A	uc001tcb.1	-	3	153	c.151C>T	c.(151-153)CTA>TTA	p.L51L	CLLU1_uc001tcc.2_5'Flank|CLLU1_uc001tcd.2_5'Flank|CLLU1_uc001tce.1_5'Flank|CLLU1_uc001tcf.2_5'Flank	NM_001025232	NP_001020403	Q5K130	CLU1O_HUMAN	chronic lymphocytic leukemia up-regulated 1	51											0						AAACTTGTTAGCAAGGCCACT	0.413000												
TPCN1	53373	broad.mit.edu	37	12	113704147	113704147	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr12:113704147C>T	uc001tuw.2	+	4	697	c.400C>T	c.(400-402)CGG>TGG	p.R134W	TPCN1_uc001tux.2_Missense_Mutation_p.R206W|TPCN1_uc010syt.1_Missense_Mutation_p.R66W	NM_017901	NP_060371	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1 isoform 2	134	Extracellular (Potential).					endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			skin(2)|ovary(1)	3						CCCCGCACTCCGGCTTGGCAT	0.617000												
SPG20	23111	broad.mit.edu	37	13	36878722	36878722	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr13:36878722G>T	uc001uvn.2	-	10	2051	c.1781C>A	c.(1780-1782)GCG>GAG	p.A594E	SPG20_uc010ten.1_Missense_Mutation_p.A584E|SPG20_uc001uvm.2_Missense_Mutation_p.A594E|SPG20_uc001uvo.2_Missense_Mutation_p.A594E|SPG20_uc001uvq.2_Missense_Mutation_p.A594E	NM_001142296	NP_001135768	Q8N0X7	SPG20_HUMAN	spartin	594					cell death	cytoplasm	ubiquitin protein ligase binding				0		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;2.42e-08)|Epithelial(112;1.58e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00128)|BRCA - Breast invasive adenocarcinoma(63;0.0125)|GBM - Glioblastoma multiforme(144;0.026)		AACATTGACCGCAGAATCCAC	0.388000												
SMAD9	4093	broad.mit.edu	37	13	37427777	37427777	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr13:37427777C>A	uc001uvw.2	-	6	1382	c.1039G>T	c.(1039-1041)GCC>TCC	p.A347S	SMAD9_uc001uvx.2_Missense_Mutation_p.A310S|SMAD9_uc010tep.1_Missense_Mutation_p.A140S	NM_001127217	NP_001120689	O15198	SMAD9_HUMAN	SMAD family member 9 isoform a	347	MH2.				BMP signaling pathway|transforming growth factor beta receptor signaling pathway	cytosol|transcription factor complex	sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity				0		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)		all cancers(112;3.38e-07)|Epithelial(112;1.93e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00804)|BRCA - Breast invasive adenocarcinoma(63;0.0129)|GBM - Glioblastoma multiforme(144;0.026)		ACGCACTCGGCATACACCTCT	0.557000												
PCDH17	27253	broad.mit.edu	37	13	58208453	58208453	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr13:58208453C>A	uc001vhq.1	+	1	2665	c.1773C>A	c.(1771-1773)GAC>GAA	p.D591E	PCDH17_uc010aec.1_Missense_Mutation_p.D591E	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	591	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TGCAGAACGACACCGCGGAGC	0.667000												
GPC6	10082	broad.mit.edu	37	13	94938678	94938678	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr13:94938678A>G	uc001vlt.2	+	5	1585	c.953A>G	c.(952-954)AAG>AGG	p.K318R	GPC6_uc010tig.1_Missense_Mutation_p.K318R	NM_005708	NP_005699	Q9Y625	GPC6_HUMAN	glypican 6 precursor	318						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				ATAGATGTCAAGATTTCTGAA	0.413000												
ZNF219	51222	broad.mit.edu	37	14	21560052	21560052	+	Silent	SNP	C	C	G			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr14:21560052C>G	uc001vzr.2	-	3	1825	c.1404G>C	c.(1402-1404)GGG>GGC	p.G468G	ZNF219_uc001vzs.2_Silent_p.G468G|ZNF219_uc010aik.1_Silent_p.G468G	NM_016423	NP_057507	Q9P2Y4	ZN219_HUMAN	zinc finger protein 219	468					negative regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|histamine receptor activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)	1	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;9.86e-11)|Epithelial(56;1.27e-08)|all cancers(55;6.06e-08)	GBM - Glioblastoma multiforme(265;0.0191)		TTGCCTGGGCCCCAGCAGCAG	0.667000												
OR10G2	26534	broad.mit.edu	37	14	22102378	22102378	+	Silent	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr14:22102378G>A	uc010tmc.1	-	1	621	c.621C>T	c.(619-621)GAC>GAT	p.D207D		NM_001005466	NP_001005466	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G,	207	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		CTACCCTGACGTCCACAAAGG	0.527000												
FITM1	161247	broad.mit.edu	37	14	24601699	24601699	+	Silent	SNP	C	C	T	rs139067370		TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr14:24601699C>T	uc001wmf.2	+	2	644	c.546C>T	c.(544-546)ACC>ACT	p.T182T		NM_203402	NP_981947	A5D6W6	FITM1_HUMAN	fat-inducing transcript 1	182	Extracellular (Potential).				lipid particle organization|positive regulation of sequestering of triglyceride	endoplasmic reticulum membrane|integral to membrane					0						GAGGCTACACCGTCTCCTCCC	0.667000												
SLC25A21	89874	broad.mit.edu	37	14	37180670	37180670	+	Silent	SNP	A	A	C			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr14:37180670A>C	uc001wtz.1	-	7	766	c.456T>G	c.(454-456)GGT>GGG	p.G152G		NM_030631	NP_085134	Q9BQT8	ODC_HUMAN	solute carrier family 25 (mitochondrial	152	Solcar 2.				lysine catabolic process	integral to membrane|mitochondrial inner membrane	alpha-ketoglutarate transmembrane transporter activity|binding			skin(1)	1	Esophageal squamous(585;0.164)|Breast(36;0.179)|Hepatocellular(127;0.213)		Lung(8;2.16e-08)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.0112)|all cancers(34;0.0274)|LUSC - Lung squamous cell carcinoma(13;0.149)	GBM - Glioblastoma multiforme(112;0.00204)		GTCTTGCATAACCCACAGTGG	0.443000												
FANCM	57697	broad.mit.edu	37	14	45620674	45620674	+	Silent	SNP	A	A	G			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr14:45620674A>G	uc001wwd.3	+	5	1092	c.993A>G	c.(991-993)AAA>AAG	p.K331K	FANCM_uc001wwc.2_Silent_p.K331K|FANCM_uc010anf.2_Silent_p.K305K	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	331					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						ATCTAACAAAATATCAGATAA	0.303000								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia			
ZFYVE1	53349	broad.mit.edu	37	14	73459882	73459882	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr14:73459882C>T	uc001xnm.2	-	4	1812	c.1172G>A	c.(1171-1173)CGG>CAG	p.R391Q	ZFYVE1_uc010arj.2_Missense_Mutation_p.R391Q	NM_021260	NP_067083	Q9HBF4	ZFYV1_HUMAN	zinc finger, FYVE domain containing 1 isoform 1	391						endoplasmic reticulum|Golgi stack|perinuclear region of cytoplasm	1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|zinc ion binding			skin(1)	1		all_lung(585;1.33e-09)		OV - Ovarian serous cystadenocarcinoma(108;1.6e-46)|BRCA - Breast invasive adenocarcinoma(234;0.00349)		TCCCGGGTGCCGGGGAGAACG	0.572000												
YLPM1	56252	broad.mit.edu	37	14	75248531	75248531	+	Silent	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr14:75248531C>T	uc001xqj.3	+	4	1909	c.1785C>T	c.(1783-1785)TCC>TCT	p.S595S	YLPM1_uc001xql.3_RNA	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		CCCCACCTTCCCTGTCTTCTG	0.582000												
SLC25A29	123096	broad.mit.edu	37	14	100765194	100765194	+	Silent	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr14:100765194C>T	uc001yha.2	-	2	354	c.63G>A	c.(61-63)CCG>CCA	p.P21P	SLC25A29_uc010twx.1_Intron|SLC25A29_uc010avw.2_Silent_p.P21P	NM_001039355	NP_001034444	Q8N8R3	MCATL_HUMAN	solute carrier family 25, member 29	21	Solcar 1.|Helical; Name=1; (Potential).					integral to membrane|mitochondrial inner membrane	binding			ovary(1)	1		Melanoma(154;0.152)			L-Carnitine(DB00583)	CCGTGTCAAACGGGTGTCCCA	0.597000												
RYR3	6263	broad.mit.edu	37	15	33855184	33855184	+	Silent	SNP	T	T	G			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr15:33855184T>G	uc001zhi.2	+	11	1189	c.1119T>G	c.(1117-1119)ACT>ACG	p.T373T	RYR3_uc010bar.2_Silent_p.T373T	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	373	Cytoplasmic (By similarity).|MIR 5.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ACGCCAAAACTTCCCGCCTGG	0.453000												
DISP2	85455	broad.mit.edu	37	15	40661112	40661112	+	Silent	SNP	G	G	A	rs140286504	byFrequency	TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr15:40661112G>A	uc001zlk.1	+	8	2888	c.2799G>A	c.(2797-2799)GCG>GCA	p.A933A		NM_033510	NP_277045	A7MBM2	DISP2_HUMAN	dispatched B	933					smoothened signaling pathway	integral to membrane				ovary(2)	2		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		GGCTGGCAGCGGAGCTGGGCA	0.607000												
MCTP2	55784	broad.mit.edu	37	15	94983411	94983411	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr15:94983411T>G	uc002btj.2	+	17	2157	c.2092T>G	c.(2092-2094)TTG>GTG	p.L698V	MCTP2_uc010boj.2_Missense_Mutation_p.L427V|MCTP2_uc010bok.2_Intron|MCTP2_uc002btl.2_Missense_Mutation_p.L286V	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	698	Helical; (Potential).				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			TCAGGTATTTTTGATCACTGT	0.378000												
OR4F15	390649	broad.mit.edu	37	15	102358857	102358857	+	Silent	SNP	A	A	C			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr15:102358857A>C	uc010uts.1	+	1	468	c.468A>C	c.(466-468)TCA>TCC	p.S156S		NM_001001674	NP_001001674	Q8NGB8	O4F15_HUMAN	olfactory receptor, family 4, subfamily F,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			TTATCCACTCATTGGTCCAAT	0.418000												
AQP8	343	broad.mit.edu	37	16	25235898	25235898	+	Splice_Site	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr16:25235898G>A	uc002doc.2	+	4	684	c.602_splice	c.e4+1	p.G201_splice		NM_001169	NP_001160	O94778	AQP8_HUMAN	aquaporin 8						cellular response to cAMP	integral to plasma membrane	water channel activity			upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(48;0.044)		TCCTGGCTGGGTGAGTGTCCC	0.512000												
SLC7A6OS	84138	broad.mit.edu	37	16	68344764	68344764	+	Silent	SNP	A	A	C	rs147089863		TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr16:68344764A>C	uc002evw.1	-	1	85	c.66T>G	c.(64-66)GCT>GCG	p.A22A	PRMT7_uc002evx.1_5'Flank|PRMT7_uc002evy.1_5'Flank|PRMT7_uc010vlg.1_5'Flank	NM_032178	NP_115554	Q96CW6	S7A6O_HUMAN	solute carrier family 7, member 6 opposite	22					protein transport	cytoplasm|nucleus				ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.106)		CGAGCACAAGAGCCTCCGCCG	0.657000												
COG8	84342	broad.mit.edu	37	16	69366758	69366758	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr16:69366758G>A	uc002ewy.2	-	4	1512	c.1441C>T	c.(1441-1443)CGC>TGC	p.R481C	PDF_uc002ewx.1_5'Flank|COG8_uc002ewz.3_Missense_Mutation_p.R481C	NM_032382	NP_115758	Q96MW5	COG8_HUMAN	component of oligomeric golgi complex 8	481					protein transport	Golgi membrane|Golgi transport complex				ovary(1)	1						TCTTCAGCGCGATGGAAGGCC	0.507000												
GLG1	2734	broad.mit.edu	37	16	74487204	74487204	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr16:74487204A>T	uc002fcy.3	-	26	3451	c.3401T>A	c.(3400-3402)CTT>CAT	p.L1134H	GLG1_uc002fcx.2_Missense_Mutation_p.L1134H|GLG1_uc002fcw.3_Missense_Mutation_p.L1123H|GLG1_uc002fcz.3_Missense_Mutation_p.L551H	NM_001145667	NP_001139139	Q92896	GSLG1_HUMAN	golgi apparatus protein 1 isoform 3	1134	Extracellular (Potential).					Golgi membrane|integral to membrane	receptor binding			ovary(1)|breast(1)	2						TTGCATGGCAAGATCAGAGAA	0.488000												
TP53	7157	broad.mit.edu	37	17	7577022	7577022	+	Nonsense_Mutation	SNP	G	G	A	rs121913344		TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr17:7577022G>A	uc002gim.2	-	8	1110	c.916C>T	c.(916-918)CGA>TGA	p.R306*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.R306*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R174*|TP53_uc010cng.1_Nonsense_Mutation_p.R174*|TP53_uc002gii.1_Nonsense_Mutation_p.R174*|TP53_uc010cnh.1_Nonsense_Mutation_p.R306*|TP53_uc010cni.1_Nonsense_Mutation_p.R306*|TP53_uc002gij.2_Nonsense_Mutation_p.R306*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	306	Bipartite nuclear localization signal.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.		R -> Q (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R306*(99)|p.0?(7)|p.?(3)|p.R306R(2)|p.R306fs*39(2)|p.K305fs*1(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGCTTACCTCGCTTAGTGCTC	0.562000	R306*(MFE296_ENDOMETRIUM)|R306*(HCC1937_BREAST)|R306*(MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R306*(RCM1_LARGE_INTESTINE)|R306*(JURLMK1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
CYB5D1	124637	broad.mit.edu	37	17	7762832	7762832	+	Missense_Mutation	SNP	C	C	T	rs62059715	byFrequency	TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr17:7762832C>T	uc002gjb.3	+	4	978	c.589C>T	c.(589-591)CGG>TGG	p.R197W	LSMD1_uc002giz.2_5'Flank|LSMD1_uc002gja.2_5'Flank|CYB5D1_uc010cnn.1_3'UTR	NM_144607	NP_653208	Q6P9G0	CB5D1_HUMAN	cytochrome b5 domain containing 1	197							heme binding			skin(1)	1		all_cancers(10;0.11)|Prostate(122;0.219)				GAATGGGATCCGGGATGAGGA	0.463000												
KRT28	162605	broad.mit.edu	37	17	38953225	38953225	+	Silent	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr17:38953225G>A	uc002hvh.1	-	5	987	c.921C>T	c.(919-921)ACC>ACT	p.T307T		NM_181535	NP_853513	Q7Z3Y7	K1C28_HUMAN	keratin 25D	307	Rod.|Coil 2.					cytoplasm|intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				GCCTCATCTCGGTGAGCTGGC	0.617000												
STAT3	6774	broad.mit.edu	37	17	40485746	40485746	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr17:40485746G>A	uc002hzl.1	-	10	1234	c.994C>T	c.(994-996)CAT>TAT	p.H332Y	STAT3_uc002hzk.1_Missense_Mutation_p.H332Y|STAT3_uc002hzm.1_Missense_Mutation_p.H332Y|STAT3_uc010wgh.1_Missense_Mutation_p.H234Y|STAT3_uc002hzn.1_Missense_Mutation_p.H332Y	NM_139276	NP_644805	P40763	STAT3_HUMAN	signal transducer and activator of transcription	332					cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)|lung(1)|breast(1)|central_nervous_system(1)	4		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		CGGTCAGGATGCATGGGCATG	0.577000									Hyperimmunoglobulin_E_Recurrent_Infection_Syndrome			
ACBD4	79777	broad.mit.edu	37	17	43213915	43213915	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr17:43213915A>G	uc002iid.2	+	3	481	c.137A>G	c.(136-138)TAC>TGC	p.Y46C	ACBD4_uc010wjj.1_Missense_Mutation_p.Y46C|ACBD4_uc002iie.2_Missense_Mutation_p.Y46C|ACBD4_uc002iif.2_Missense_Mutation_p.Y46C|ACBD4_uc002iic.2_Missense_Mutation_p.Y46C|ACBD4_uc010dae.2_5'UTR	NM_001135707	NP_001129179	Q8NC06	ACBD4_HUMAN	acyl-Coenzyme A binding domain containing 4	46	ACB.						fatty-acyl-CoA binding			ovary(1)|kidney(1)	2						TACAGTTACTACAAGCAGGCC	0.602000												
GPRC5C	55890	broad.mit.edu	37	17	72436661	72436661	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr17:72436661C>A	uc002jks.2	+	1	785	c.746C>A	c.(745-747)ACA>AAA	p.T249K	GPRC5C_uc002jkp.2_Missense_Mutation_p.T294K|GPRC5C_uc002jkq.2_Intron|GPRC5C_uc002jkr.2_Missense_Mutation_p.T261K|GPRC5C_uc002jkt.2_Missense_Mutation_p.T249K|GPRC5C_uc002jku.2_5'Flank	NM_018653	NP_061123	Q9NQ84	GPC5C_HUMAN	G protein-coupled receptor family C, group 5,	249	Helical; Name=6; (Potential).					cytoplasmic vesicle membrane|integral to plasma membrane	G-protein coupled receptor activity|protein binding			ovary(2)|prostate(1)|central_nervous_system(1)|pancreas(1)	5						CTCCTCACCACAGCCACCTCC	0.617000												
DSEL	92126	broad.mit.edu	37	18	65180695	65180695	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr18:65180695G>A	uc002lke.1	-	2	2405	c.1181C>T	c.(1180-1182)ACT>ATT	p.T394I		NM_032160	NP_115536	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	384						integral to membrane	isomerase activity|sulfotransferase activity			ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	6		Esophageal squamous(42;0.129)				AGTGTGAAGAGTACTCCACCT	0.458000												
MUC16	94025	broad.mit.edu	37	19	9047473	9047473	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr19:9047473T>G	uc002mkp.2	-	5	34362	c.34158A>C	c.(34156-34158)GAA>GAC	p.E11386D		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11388	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGAAGTGGCTTCTGCCCCAG	0.468000												
CDC37	11140	broad.mit.edu	37	19	10505732	10505732	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr19:10505732G>A	uc002mof.1	-	5	807	c.691C>T	c.(691-693)CGG>TGG	p.R231W	CDC37_uc002moe.1_Missense_Mutation_p.R186W|CDC37_uc010dxf.1_Missense_Mutation_p.R68W|CDC37_uc002mog.1_Intron|CDC37_uc002moh.2_Missense_Mutation_p.R231W	NM_007065	NP_008996	Q16543	CDC37_HUMAN	cell division cycle 37 protein	231					protein targeting|regulation of cyclin-dependent protein kinase activity|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway		unfolded protein binding				0			OV - Ovarian serous cystadenocarcinoma(20;4.65e-10)|Epithelial(33;6.48e-07)|all cancers(31;2.31e-06)	GBM - Glioblastoma multiforme(1328;0.0318)		AAGCAGGCCCGGGGGTCCACC	0.582000												
CPAMD8	27151	broad.mit.edu	37	19	17008738	17008738	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr19:17008738G>A	uc002nfb.2	-	38	5089	c.5057C>T	c.(5056-5058)TCG>TTG	p.S1686L	CPAMD8_uc010xpj.1_5'Flank|CPAMD8_uc002nfd.1_Missense_Mutation_p.S151L	NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	1639						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						TGGCAGCGCCGACGTCCTGCC	0.587000												
DDX49	54555	broad.mit.edu	37	19	19035507	19035507	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr19:19035507C>T	uc002nkq.1	+	8	985	c.928C>T	c.(928-930)CGG>TGG	p.R310W	HOMER3_uc002nko.1_Intron|HOMER3_uc002nkp.1_Intron|DDX49_uc002nkr.1_RNA|DDX49_uc002nks.1_Missense_Mutation_p.R203W|DDX49_uc002nkt.1_Missense_Mutation_p.R192W	NM_019070	NP_061943	Q9Y6V7	DDX49_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 49	310	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1			Epithelial(12;0.0289)			CGTGGCCTCCCGGTGAGCAGC	0.577000												
C19orf2	8725	broad.mit.edu	37	19	30502064	30502064	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr19:30502064C>T	uc002nsr.2	+	9	1129	c.1099C>T	c.(1099-1101)CGT>TGT	p.R367C	C19orf2_uc002nsq.2_Missense_Mutation_p.R349C|C19orf2_uc002nss.2_Missense_Mutation_p.R327C|C19orf2_uc002nst.2_Missense_Mutation_p.R291C	NM_003796	NP_003787	O94763	RMP_HUMAN	RPB5-mediating protein isoform a	367					protein folding|regulation of transcription from RNA polymerase II promoter|response to virus	DNA-directed RNA polymerase II, core complex|prefoldin complex	transcription corepressor activity|unfolded protein binding			ovary(1)|kidney(1)	2	Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)	Hepatocellular(1079;0.137)|Renal(1328;0.228)	STAD - Stomach adenocarcinoma(5;5.36e-06)|Lung(7;0.0144)|LUAD - Lung adenocarcinoma(5;0.115)	STAD - Stomach adenocarcinoma(1328;0.18)		AGAAGCCAAACGTAAACGAAA	0.453000												
ZNF568	374900	broad.mit.edu	37	19	37440970	37440970	+	Silent	SNP	T	T	G			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr19:37440970T>G	uc002ofc.2	+	7	1430	c.915T>G	c.(913-915)CCT>CCG	p.P305P	ZNF568_uc010efg.2_Intron|ZNF568_uc010xtn.1_Intron|ZNF568_uc002ofd.2_Silent_p.P229P|ZNF568_uc010efe.2_Silent_p.P229P|ZNF568_uc010eff.1_Intron	NM_198539	NP_940941	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	305					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GGGAGAAACCTTATGCATGTA	0.378000												
LYPD4	147719	broad.mit.edu	37	19	42343074	42343074	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr19:42343074T>C	uc002orp.1	-	3	1076	c.92A>G	c.(91-93)GAA>GGA	p.E31G	LYPD4_uc002orq.1_Intron	NM_173506	NP_775777	Q6UWN0	LYPD4_HUMAN	LY6/PLAUR domain containing 4 precursor	31						anchored to membrane|plasma membrane				ovary(1)	1						GGCTGTTGCTTCATAGCACAA	0.502000												
ATP1A3	478	broad.mit.edu	37	19	42471430	42471430	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr19:42471430C>T	uc002osg.2	-	22	3138	c.2984G>A	c.(2983-2985)CGC>CAC	p.R995H	ATP1A3_uc010xwf.1_Missense_Mutation_p.R1006H|ATP1A3_uc010xwg.1_Missense_Mutation_p.R965H|ATP1A3_uc010xwh.1_Missense_Mutation_p.R1008H|ATP1A3_uc002osh.2_Missense_Mutation_p.R995H	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	995	Helical; (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2						GATGAGTTTGCGGATTTCGTC	0.662000												
PSG1	5669	broad.mit.edu	37	19	43348747	43348747	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr19:43348747C>A	uc002oux.1	-	5	1198	c.1049G>T	c.(1048-1050)AGA>ATA	p.R350I	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG8_uc002ouj.3_Intron|PSG8_uc002ouk.3_Intron|PSG8_uc002oul.3_Intron|PSG8_uc002oum.3_Intron|PSG1_uc002oun.2_RNA|PSG8_uc002oup.3_Intron|PSG10_uc010eip.2_RNA|PSG1_uc002our.1_Intron|PSG1_uc010eio.1_Intron|PSG1_uc002ouy.1_Missense_Mutation_p.R328I	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	336	Ig-like C2-type 3.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				AGGGTAAATTCTGGGGAGGTC	0.483000												
ZNF813	126017	broad.mit.edu	37	19	53995030	53995030	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr19:53995030G>T	uc002qbu.2	+	4	1672	c.1544G>T	c.(1543-1545)AGA>ATA	p.R515I	ZNF813_uc010eqq.1_Intron	NM_001004301	NP_001004301	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	515	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		TGTCATCATAGACTTCATACT	0.383000												
LILRA3	11026	broad.mit.edu	37	19	54803095	54803095	+	Silent	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr19:54803095C>T	uc002qfd.2	-	4	647	c.582G>A	c.(580-582)TCG>TCA	p.S194S	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Intron	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	194	Ig-like C2-type 2.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		AGCACCTGTACGACCACCTGC	0.587000												
ZNF471	57573	broad.mit.edu	37	19	57036519	57036519	+	Silent	SNP	T	T	C			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr19:57036519T>C	uc002qnh.2	+	5	1216	c.1083T>C	c.(1081-1083)TTT>TTC	p.F361F		NM_020813	NP_065864	Q9BX82	ZN471_HUMAN	zinc finger protein 471	361	C2H2-type 6.		F -> C (in a colorectal cancer sample; somatic mutation).		regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.F361C(1)		large_intestine(1)|ovary(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		ACACATCTTTTATTCGTCACT	0.418000												
PXDN	7837	broad.mit.edu	37	2	1652393	1652393	+	Silent	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr2:1652393G>A	uc002qxa.2	-	17	3223	c.3159C>T	c.(3157-3159)TAC>TAT	p.Y1053Y		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	1053					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		TGCCGGGGTCGTAGCCGTGGT	0.617000												
TMEM131	23505	broad.mit.edu	37	2	98392446	98392446	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr2:98392446G>A	uc002syh.3	-	32	4409	c.4180C>T	c.(4180-4182)CCT>TCT	p.P1394S		NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	1394	Lys-rich.					integral to membrane				ovary(4)|central_nervous_system(2)	6						TGCTTCTTAGGTGGTTTCACC	0.378000												
CPS1	1373	broad.mit.edu	37	2	211465372	211465372	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr2:211465372A>C	uc002vee.3	+	15	1775	c.1643A>C	c.(1642-1644)CAG>CCG	p.Q548P	CPS1_uc010fur.2_Missense_Mutation_p.Q554P|CPS1_uc010fus.2_Missense_Mutation_p.Q97P	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	548					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		GAAGACAGGCAGCTGTTTTCA	0.408000												
ACSL3	2181	broad.mit.edu	37	2	223773557	223773557	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr2:223773557T>A	uc002vni.2	+	4	518	c.67T>A	c.(67-69)TTA>ATA	p.L23I	ACSL3_uc002vnj.2_Missense_Mutation_p.L23I	NM_004457	NP_004448	O95573	ACSL3_HUMAN	acyl-CoA synthetase long-chain family member 3	23	Helical; Signal-anchor for type III membrane protein; (Potential).				long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|fatty-acyl-CoA synthase activity|long-chain fatty acid-CoA ligase activity|protein binding			ovary(2)	2		Renal(207;0.0183)		Epithelial(121;1.28e-10)|all cancers(144;8.06e-08)|Lung(261;0.00834)|LUSC - Lung squamous cell carcinoma(224;0.00864)	Icosapent(DB00159)	CCCTATTCTTTTATATTTTAT	0.289000			T	ETV1	prostate							
DOCK10	55619	broad.mit.edu	37	2	225688336	225688336	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr2:225688336G>T	uc010fwz.1	-	28	3304	c.3065C>A	c.(3064-3066)TCT>TAT	p.S1022Y	DOCK10_uc002vob.2_Missense_Mutation_p.S1016Y	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1022							GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		ATTTTGGTAAGATTCAGGAAA	0.408000												
FAM113A	64773	broad.mit.edu	37	20	2818920	2818920	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr20:2818920C>T	uc002wgz.1	-	6	1296	c.799G>A	c.(799-801)GAC>AAC	p.D267N	FAM113A_uc002whb.1_Missense_Mutation_p.D118N|FAM113A_uc002wha.1_Missense_Mutation_p.D118N|FAM113A_uc010zqa.1_Missense_Mutation_p.D114N|FAM113A_uc002whc.1_Missense_Mutation_p.D216N|VPS16_uc002whe.2_5'Flank|VPS16_uc002whf.2_5'Flank|VPS16_uc002whd.2_5'Flank	NM_022760	NP_073597	Q9H1Q7	F113A_HUMAN	hypothetical protein LOC64773	267							hydrolase activity|protein binding			ovary(2)	2						CCCCAGGCGTCAGCCACATGG	0.637000												
C20orf3	57136	broad.mit.edu	37	20	24954292	24954292	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr20:24954292G>A	uc002wty.2	-	4	511	c.410C>T	c.(409-411)TCG>TTG	p.S137L	C20orf3_uc002wtz.2_Missense_Mutation_p.S137L|C20orf3_uc010zsw.1_Missense_Mutation_p.S137L	NM_020531	NP_065392	Q9HDC9	APMAP_HUMAN	chromosome 20 open reading frame 3	137	Extracellular (Potential).				biosynthetic process	cell surface|integral to membrane	arylesterase activity|strictosidine synthase activity			ovary(1)	1						GCAAGGGCCCGAACCAAACCG	0.443000												
MYBL2	4605	broad.mit.edu	37	20	42344707	42344707	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr20:42344707C>T	uc002xlb.1	+	14	2298	c.2083C>T	c.(2083-2085)CGG>TGG	p.R695W	MYBL2_uc010zwj.1_Missense_Mutation_p.R671W	NM_002466	NP_002457	P10244	MYBB_HUMAN	MYB-related protein B	695						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(3)|kidney(2)	5		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CCACACATCTCGGACCCTCAT	0.607000												
EEF1A2	1917	broad.mit.edu	37	20	62126325	62126325	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr20:62126325C>T	uc002yfd.1	-	3	555	c.454G>A	c.(454-456)GTG>ATG	p.V152M	EEF1A2_uc002yfe.1_Missense_Mutation_p.V152M|EEF1A2_uc010gkg.1_Missense_Mutation_p.V152M	NM_001958	NP_001949	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha	152						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			ATTTTGTTCACGCCCACGATG	0.607000												
ZDHHC8	29801	broad.mit.edu	37	22	20130417	20130417	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr22:20130417G>A	uc002zrq.2	+	10	1370	c.1264G>A	c.(1264-1266)GCC>ACC	p.A422T	ZDHHC8_uc002zrr.1_Missense_Mutation_p.A422T|ZDHHC8_uc010gsa.2_Missense_Mutation_p.A228T	NM_013373	NP_037505	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC domain containing 8	422	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Colorectal(54;0.0993)					ACCGCTCAGCGCCTCTGATGC	0.692000												
PFKFB4	5210	broad.mit.edu	37	3	48587369	48587369	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr3:48587369C>T	uc003ctv.2	-	3	256	c.239G>A	c.(238-240)CGG>CAG	p.R80Q	PFKFB4_uc003ctw.2_5'UTR|PFKFB4_uc010hkc.2_Missense_Mutation_p.R80Q|PFKFB4_uc003ctx.2_Missense_Mutation_p.R37Q|PFKFB4_uc010hkb.2_Missense_Mutation_p.R80Q|PFKFB4_uc011bbm.1_Missense_Mutation_p.R69Q|PFKFB4_uc011bbn.1_RNA	NM_004567	NP_004558	Q16877	F264_HUMAN	6-phosphofructo-2-kinase/fructose-2,	80	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0003)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		GACCACGTCCCGGCGATACTG	0.517000												
QARS	5859	broad.mit.edu	37	3	49139687	49139687	+	Silent	SNP	A	A	C			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr3:49139687A>C	uc003cvx.2	-	7	587	c.582T>G	c.(580-582)GCT>GCG	p.A194A	QARS_uc011bcc.1_5'Flank|QARS_uc011bcd.1_Silent_p.A49A|QARS_uc003cvy.2_Silent_p.A49A|QARS_uc011bce.1_Silent_p.A183A|QARS_uc011bcf.1_Silent_p.A194A	NM_005051	NP_005042	P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	194					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	CTTCTAGCCGAGCTTTTGCCA	0.507000												
VPRBP	9730	broad.mit.edu	37	3	51457862	51457862	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr3:51457862T>C	uc003dbe.1	-	14	2730	c.2562A>G	c.(2560-2562)ATA>ATG	p.I854M	VPRBP_uc003dbf.1_Missense_Mutation_p.I130M	NM_014703	NP_055518	Q9Y4B6	VPRBP_HUMAN	HIV-1 Vpr binding protein	854	LisH.				interspecies interaction between organisms	cytoplasm|nucleus	protein binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		GATGGTTTCGTATCAACAAAA	0.478000												
SNTN	132203	broad.mit.edu	37	3	63638466	63638466	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr3:63638466C>T	uc003dlr.2	+	1	123	c.103C>T	c.(103-105)CCC>TCC	p.P35S		NM_001080537	NP_001074006	A6NMZ2	SNTAN_HUMAN	sentan, cilia apical structure protein	35						cilium	calcium ion binding			ovary(1)	1						TAGGAAAATGCCCAAAAGGTC	0.453000												
ARL13B	200894	broad.mit.edu	37	3	93758757	93758757	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr3:93758757T>G	uc003drc.2	+	6	1009	c.723T>G	c.(721-723)GAT>GAG	p.D241E	ARL13B_uc010hop.2_Missense_Mutation_p.D92E|ARL13B_uc003drd.2_Missense_Mutation_p.D134E|ARL13B_uc003dre.2_Missense_Mutation_p.D226E|ARL13B_uc003drf.2_Missense_Mutation_p.D241E|ARL13B_uc003drg.2_Missense_Mutation_p.D138E	NM_182896	NP_878899	Q3SXY8	AR13B_HUMAN	ADP-ribosylation factor-like 2-like 1 isoform 1	241	Potential.						GTP binding				0						CTGAACTCGATGGAACCAGTG	0.393000												
MRPL47	57129	broad.mit.edu	37	3	179311560	179311560	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr3:179311560T>G	uc003fjz.2	-	5	548	c.526A>C	c.(526-528)ATC>CTC	p.I176L	MRPL47_uc003fka.2_Missense_Mutation_p.I66L|MRPL47_uc003fkb.2_Missense_Mutation_p.I156L	NM_020409	NP_065142	Q9HD33	RM47_HUMAN	mitochondrial ribosomal protein L47 isoform a	176					translation	mitochondrial ribosome	structural constituent of ribosome				0	all_cancers(143;9.62e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.18)			TACCAGATGATTCTTCCAAAG	0.413000												
EVC	2121	broad.mit.edu	37	4	5733156	5733156	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr4:5733156T>C	uc003gil.1	+	4	573	c.389T>C	c.(388-390)CTG>CCG	p.L130P	EVC_uc003gim.1_RNA	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	130					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)				CCCCAGCCTCTGGCCGATGGC	0.542000												
LDB2	9079	broad.mit.edu	37	4	16587554	16587554	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr4:16587554G>C	uc003goz.2	-	5	922	c.606C>G	c.(604-606)AAC>AAG	p.N202K	LDB2_uc003gpa.2_Missense_Mutation_p.N202K|LDB2_uc003gpb.2_Missense_Mutation_p.N202K|LDB2_uc011bxh.1_Intron|LDB2_uc010iee.2_Missense_Mutation_p.N202K|LDB2_uc003goy.2_Missense_Mutation_p.N78K|LDB2_uc011bxi.1_Missense_Mutation_p.N78K	NM_001290	NP_001281	O43679	LDB2_HUMAN	LIM domain binding 2 isoform a	202							LIM domain binding|transcription cofactor activity				0						CCCTGAGGTAGTTGAGGGTGA	0.408000												
SPATA18	132671	broad.mit.edu	37	4	52926960	52926960	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr4:52926960A>T	uc003gzl.2	+	3	484	c.206A>T	c.(205-207)GAT>GTT	p.D69V	SPATA18_uc010igl.1_RNA|SPATA18_uc011bzq.1_Missense_Mutation_p.D69V|SPATA18_uc003gzk.1_Missense_Mutation_p.D69V	NM_145263	NP_660306	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18 homolog	69					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			ovary(2)|skin(2)	4			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			GGACGTAATGATGGTGTGGAA	0.294000												
KDR	3791	broad.mit.edu	37	4	55968591	55968591	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr4:55968591G>T	uc003has.2	-	14	2374	c.2072C>A	c.(2071-2073)TCT>TAT	p.S691Y	KDR_uc003hat.1_Missense_Mutation_p.S691Y	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	691	Ig-like C2-type 7.|Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GGGATTCCCAGATGCCGTGCA	0.468000			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)		
KIAA1109	84162	broad.mit.edu	37	4	123252486	123252486	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr4:123252486C>T	uc003ieh.2	+	65	11300	c.11255C>T	c.(11254-11256)ACG>ATG	p.T3752M	KIAA1109_uc003iem.2_Missense_Mutation_p.T143M	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	3752					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TGTAGACATACGTCTCGTAAA	0.373000												
FAT4	79633	broad.mit.edu	37	4	126241072	126241072	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr4:126241072G>A	uc003ifj.3	+	1	3506	c.3506G>A	c.(3505-3507)CGG>CAG	p.R1169Q		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1169	Cadherin 11.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CTTATGAGGCGGAGAGGGACT	0.453000												
ZNF827	152485	broad.mit.edu	37	4	146806888	146806888	+	Silent	SNP	T	T	C			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr4:146806888T>C	uc003ikn.2	-	4	1737	c.1689A>G	c.(1687-1689)GCA>GCG	p.A563A	ZNF827_uc003ikm.2_Silent_p.A563A|ZNF827_uc010iox.2_Silent_p.A213A	NM_178835	NP_849157	Q17R98	ZN827_HUMAN	zinc finger protein 827	563					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_hematologic(180;0.151)					GGCTGAACAATGCTGACGCAC	0.458000												
NPY1R	4886	broad.mit.edu	37	4	164246633	164246633	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr4:164246633T>G	uc003iqm.1	-	3	1243	c.977A>C	c.(976-978)AAC>ACC	p.N326T	NPY1R_uc011cjj.1_Missense_Mutation_p.N83T	NM_000909	NP_000900	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	326	Cytoplasmic (Potential).				inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			lung(1)|pancreas(1)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TCTCTGGAAGTTTTTGTTCAG	0.428000												
PRDM9	56979	broad.mit.edu	37	5	23522743	23522743	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr5:23522743T>G	uc003jgo.2	+	8	813	c.631T>G	c.(631-633)TTC>GTC	p.F211V		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	211					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GTGTCAGAACTTCTTCATTGA	0.498000										HNSCC(3;0.000094)		
ERBB2IP	55914	broad.mit.edu	37	5	65288677	65288678	+	Missense_Mutation	DNP	TT	TT	AC			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr5:65288677_65288678TT>AC	uc003juk.1	+	3	439_440	c.131_132TT>AC	c.(130-132)TTT>TAC	p.F44Y	ERBB2IP_uc003juh.1_Missense_Mutation_p.F44Y|ERBB2IP_uc003jui.1_Missense_Mutation_p.F44Y|ERBB2IP_uc003juj.1_Missense_Mutation_p.F44Y|ERBB2IP_uc011cqx.1_Missense_Mutation_p.F44Y|ERBB2IP_uc011cqy.1_Missense_Mutation_p.F44Y|ERBB2IP_uc011cqz.1_Missense_Mutation_p.F44Y|ERBB2IP_uc010iwx.1_Missense_Mutation_p.F44Y|ERBB2IP_uc003jul.1_Missense_Mutation_p.F44Y	NM_018695	NP_061165	Q96RT1	LAP2_HUMAN	ERBB2 interacting protein isoform 2	44	LRR 1.				basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			ovary(3)|lung(2)|central_nervous_system(2)	7		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		ATTTTTACTTTTGAAAAAACCT	0.361000												
GPR98	84059	broad.mit.edu	37	5	89954028	89954028	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr5:89954028G>T	uc003kju.2	+	21	4781	c.4685G>T	c.(4684-4686)AGA>ATA	p.R1562I	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	1562	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ACTACTGCAAGATTAACAATA	0.363000												
FAM81B	153643	broad.mit.edu	37	5	94764400	94764400	+	Silent	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr5:94764400C>T	uc003kla.1	+	6	796	c.750C>T	c.(748-750)CCC>CCT	p.P250P	FAM81B_uc010jbe.1_Silent_p.P46P	NM_152548	NP_689761	Q96LP2	FA81B_HUMAN	hypothetical protein LOC153643	250										ovary(1)|skin(1)	2		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		AATTCGTGCCCGCCCTGGAAA	0.408000												
SLC25A46	91137	broad.mit.edu	37	5	110097216	110097216	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr5:110097216C>G	uc003koz.2	+	8	1058	c.991C>G	c.(991-993)CTT>GTT	p.L331V	SLC25A46_uc011cvi.1_Missense_Mutation_p.L240V	NM_138773	NP_620128	Q96AG3	S2546_HUMAN	solute carrier family 25, member 46	331	Solcar 2.|Helical; Name=5; (Potential).				transport	integral to membrane|mitochondrial inner membrane					0		all_cancers(142;0.00203)|all_epithelial(76;4.52e-05)|Prostate(80;0.0115)|Colorectal(57;0.0676)|Ovarian(225;0.156)		OV - Ovarian serous cystadenocarcinoma(64;2.58e-09)|Epithelial(69;7.29e-08)|all cancers(49;9.35e-06)|COAD - Colon adenocarcinoma(37;0.211)		TGACGTTATACTTTACCCATT	0.423000												
ZNF300	91975	broad.mit.edu	37	5	150275190	150275190	+	Silent	SNP	C	C	T	rs140923053		TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr5:150275190C>T	uc003lsy.1	-	6	1878	c.1611G>A	c.(1609-1611)CCG>CCA	p.P537P	IRGM_uc011dcl.1_Intron	NM_052860	NP_443092	Q96RE9	ZN300_HUMAN	zinc finger protein 300	537	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.131)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCTGGTGTCCCGGAAGGTGGG	0.428000												
DUSP22	56940	broad.mit.edu	37	6	345906	345906	+	Missense_Mutation	SNP	G	G	A	rs148279164		TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr6:345906G>A	uc003msx.2	+	5	680	c.241G>A	c.(241-243)GGT>AGT	p.G81S	DUSP22_uc011dhn.1_Missense_Mutation_p.G81S|DUSP22_uc003msy.1_Missense_Mutation_p.G38S	NM_020185	NP_064570	Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	81	Tyrosine-protein phosphatase.				apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		CCGGCTCCGCGGTGAGAGCTG	0.438000												
NUP153	9972	broad.mit.edu	37	6	17629488	17629488	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr6:17629488A>C	uc003ncd.1	-	18	3142	c.2942T>G	c.(2941-2943)TTT>TGT	p.F981C	NUP153_uc011dje.1_Missense_Mutation_p.F1012C|NUP153_uc010jpl.1_Missense_Mutation_p.F939C	NM_005124	NP_005115	P49790	NU153_HUMAN	nucleoporin 153kDa	981					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			lung(4)|ovary(2)|breast(2)|skin(1)	9	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			TCCAAACTTAAAATTATCATT	0.323000												
C6orf134	79969	broad.mit.edu	37	6	30610778	30610778	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr6:30610778C>T	uc003nqu.2	+	10	1008	c.958C>T	c.(958-960)CGT>TGT	p.R320C	C6orf134_uc003nqr.3_Missense_Mutation_p.R320C|C6orf134_uc003rdc.2_Missense_Mutation_p.R320C|C6orf134_uc003nqs.3_Missense_Mutation_p.R297C|C6orf134_uc003rdd.2_Missense_Mutation_p.R297C|C6orf134_uc003nqt.2_Intron|C6orf134_uc011dmm.1_Missense_Mutation_p.R285C|C6orf134_uc003nqv.2_Missense_Mutation_p.R308C	NM_024909	NP_079185	Q5SQI0	ATAT_HUMAN	hypothetical protein LOC79969 isoform 2	320							tubulin N-acetyltransferase activity				0						AGCTCAACGTCGTCGCACCAG	0.572000												
BRD2	6046	broad.mit.edu	37	6	32945244	32945244	+	Missense_Mutation	SNP	G	G	T	rs141044200		TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr6:32945244G>T	uc003ocn.3	+	8	2927	c.1226G>T	c.(1225-1227)CGG>CTG	p.R409L	BRD2_uc003oco.2_RNA|BRD2_uc003ocq.3_Missense_Mutation_p.R409L|BRD2_uc003ocp.3_Missense_Mutation_p.R289L|BRD2_uc010juh.2_Missense_Mutation_p.R409L	NM_005104	NP_005095	P25440	BRD2_HUMAN	bromodomain containing 2	409	Bromo 2.				spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						CGTGATTACCGGGATGCACAG	0.522000												
KCNK5	8645	broad.mit.edu	37	6	39159379	39159379	+	Missense_Mutation	SNP	G	G	A	rs150380866	byFrequency	TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr6:39159379G>A	uc003oon.2	-	5	1151	c.787C>T	c.(787-789)CGG>TGG	p.R263W		NM_003740	NP_003731	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	263	Cytoplasmic (Potential).				excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						GACTCCTTCCGTCGCCGCCGC	0.562000												
UTRN	7402	broad.mit.edu	37	6	144811268	144811268	+	Missense_Mutation	SNP	G	G	A	rs151173089		TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr6:144811268G>A	uc003qkt.2	+	30	4288	c.4196G>A	c.(4195-4197)CGT>CAT	p.R1399H		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	1399	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		AGAAATATGCGTTCTCAGCCC	0.473000												
PPIL4	85313	broad.mit.edu	37	6	149826767	149826767	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr6:149826767T>C	uc003qmo.1	-	13	1331	c.1301A>G	c.(1300-1302)AAG>AGG	p.K434R	PPIL4_uc010kic.2_Intron	NM_139126	NP_624311	Q8WUA2	PPIL4_HUMAN	peptidylprolyl isomerase-like 4	434					protein folding	nucleus	nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|RNA binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.11e-11)|GBM - Glioblastoma multiforme(68;0.0885)		TCGGTCTCTCTTTTCACTCTT	0.398000												
LPA	4018	broad.mit.edu	37	6	161010612	161010612	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr6:161010612T>C	uc003qtl.2	-	25	4040	c.3920A>G	c.(3919-3921)CAG>CGG	p.Q1307R		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3815	Kringle 34.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TGTGGTTCTCTGATGCCAGTG	0.473000												
GLI3	2737	broad.mit.edu	37	7	42004616	42004616	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr7:42004616G>T	uc011kbh.1	-	15	4146	c.4055C>A	c.(4054-4056)TCA>TAA	p.S1352*	GLI3_uc011kbg.1_Nonsense_Mutation_p.S1293*	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1352					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						GTTGATGTGTGAGGTAGCACT	0.647000									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome			
POLD2	5425	broad.mit.edu	37	7	44157562	44157562	+	Silent	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr7:44157562G>A	uc010kxz.2	-	4	972	c.322C>T	c.(322-324)CTG>TTG	p.L108L	POLD2_uc003tke.3_Silent_p.L108L|POLD2_uc010kya.2_Silent_p.L108L|POLD2_uc003tkf.3_Silent_p.L108L	NM_006230	NP_006221	P49005	DPOD2_HUMAN	DNA-directed DNA polymerase delta 2	108					base-excision repair|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity|protein binding			ovary(2)	2						ACCTCCCGCAGGATGGAGGGC	0.632000												
SLC13A1	6561	broad.mit.edu	37	7	122765669	122765669	+	Silent	SNP	A	A	G			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr7:122765669A>G	uc003vkm.2	-	11	1219	c.1194T>C	c.(1192-1194)CTT>CTC	p.L398L	SLC13A1_uc010lks.2_Silent_p.L274L	NM_022444	NP_071889	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate	398	Helical; (Potential).					integral to membrane|plasma membrane	sodium:sulfate symporter activity			ovary(2)	2					Succinic acid(DB00139)	TAGCTGGGATAAGAAAGAATA	0.333000												
OR2F1	26211	broad.mit.edu	37	7	143657178	143657178	+	Missense_Mutation	SNP	G	G	A	rs141187562	byFrequency	TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr7:143657178G>A	uc003wds.1	+	1	159	c.115G>A	c.(115-117)GTG>ATG	p.V39M		NM_012369	NP_036501	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F,	39	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	Melanoma(164;0.0903)					TGTGGTGACCGTGCTGGGGAA	0.522000												
MLL3	58508	broad.mit.edu	37	7	151932911	151932911	+	Silent	SNP	T	T	C			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr7:151932911T>C	uc003wla.2	-	16	2979	c.2760A>G	c.(2758-2760)GTA>GTG	p.V920V	MLL3_uc003wkz.2_5'UTR	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	920					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CCCCAGGTAATACAACAGCTC	0.453000			N		medulloblastoma							
CSMD1	64478	broad.mit.edu	37	8	3200843	3200843	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr8:3200843C>T	uc011kwk.1	-	23	3997	c.3607G>A	c.(3607-3609)GAC>AAC	p.D1203N	CSMD1_uc011kwj.1_Missense_Mutation_p.D595N|CSMD1_uc003wqe.2_Missense_Mutation_p.D359N	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1203	Extracellular (Potential).|CUB 7.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AAACCTTGGTCGGTGTCAGAT	0.408000												
PRSS55	203074	broad.mit.edu	37	8	10396212	10396212	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr8:10396212C>T	uc003wta.2	+	5	983	c.968C>T	c.(967-969)CCA>CTA	p.P323L	uc010lru.2_Intron|PRSS55_uc003wtb.2_Intron	NM_198464	NP_940866	Q6UWB4	PRS55_HUMAN	hypothetical protein LOC203074 precursor	323	Extracellular (Potential).				proteolysis	integral to membrane	serine-type endopeptidase activity			ovary(1)	1						ATGGGCTCCCCAGTCTCGGGA	0.517000												
DLC1	10395	broad.mit.edu	37	8	13258989	13258989	+	Missense_Mutation	SNP	C	C	T	rs150701452		TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr8:13258989C>T	uc003wwm.2	-	3	1607	c.1163G>A	c.(1162-1164)CGG>CAG	p.R388Q	DLC1_uc003wwn.2_Missense_Mutation_p.R388Q|DLC1_uc011kxy.1_Missense_Mutation_p.R388Q	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	388					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						AGGAACGTGCCGCCGCAGGTT	0.483000												
TUSC3	7991	broad.mit.edu	37	8	15480646	15480646	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr8:15480646T>G	uc003wwt.2	+	2	406	c.196T>G	c.(196-198)TTC>GTC	p.F66V	TUSC3_uc003wwr.2_Missense_Mutation_p.F66V|TUSC3_uc003wws.2_Missense_Mutation_p.F66V|TUSC3_uc003wwu.2_Missense_Mutation_p.F66V|TUSC3_uc003wwv.2_Missense_Mutation_p.F66V|TUSC3_uc003www.2_Missense_Mutation_p.F66V|TUSC3_uc003wwx.2_RNA|TUSC3_uc003wwy.2_Missense_Mutation_p.F66V	NM_006765	NP_006756	Q13454	TUSC3_HUMAN	tumor suppressor candidate 3 isoform a	66					cell redox homeostasis|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				ovary(2)|central_nervous_system(1)	3				Colorectal(111;0.113)		ACGCTCAATCTTCCGAATGAA	0.388000												
ZMAT4	79698	broad.mit.edu	37	8	40625183	40625183	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr8:40625183C>A	uc003xnr.2	-	3	315	c.169G>T	c.(169-171)GCC>TCC	p.A57S	ZMAT4_uc003xns.2_Missense_Mutation_p.A57S	NM_024645	NP_078921	Q9H898	ZMAT4_HUMAN	zinc finger, matrin type 4 isoform a	57						nucleus	DNA binding|zinc ion binding			pancreas(1)|central_nervous_system(1)|skin(1)	3	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)			AGCCTCTTGGCAGGACACCCT	0.453000												
RP1	6101	broad.mit.edu	37	8	55541424	55541424	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr8:55541424C>G	uc003xsd.1	+	4	5130	c.4982C>G	c.(4981-4983)TCT>TGT	p.S1661C	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1661					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CCTTATAATTCTGTGGAATTT	0.388000												
FAM82B	51115	broad.mit.edu	37	8	87491204	87491204	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr8:87491204C>T	uc003ydu.2	-	7	837	c.677G>A	c.(676-678)AGA>AAA	p.R226K	FAM82B_uc011lfz.1_Missense_Mutation_p.R196K|FAM82B_uc011lga.1_Missense_Mutation_p.R196K	NM_016033	NP_057117	Q96DB5	RMD1_HUMAN	regulator of microtubule dynamics 1	226	TPR 2.					microtubule|spindle pole	binding			ovary(1)	1						AGCAATTCTTCTTTGATACCA	0.348000												
SDC2	6383	broad.mit.edu	37	8	97614693	97614693	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr8:97614693T>G	uc003yhv.1	+	3	861	c.243T>G	c.(241-243)AGT>AGG	p.S81R	SDC2_uc011lgu.1_Missense_Mutation_p.S52R	NM_002998	NP_002989	P34741	SDC2_HUMAN	syndecan 2 precursor	81	Extracellular (Potential).					integral to plasma membrane	cytoskeletal protein binding|PDZ domain binding			ovary(2)	2	Breast(36;3.41e-05)				Sargramostim(DB00020)	TGTTGACTAGTGCTGCTCCAA	0.438000												
ANGPT1	284	broad.mit.edu	37	8	108306233	108306233	+	Silent	SNP	A	A	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr8:108306233A>T	uc003ymn.2	-	6	1437	c.969T>A	c.(967-969)GGT>GGA	p.G323G	ANGPT1_uc011lhv.1_Silent_p.G123G|ANGPT1_uc003ymo.2_Silent_p.G322G|ANGPT1_uc003ymp.3_Silent_p.G122G	NM_001146	NP_001137	Q15389	ANGP1_HUMAN	angiopoietin 1 precursor	323	Fibrinogen C-terminal.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			ovary(3)|skin(3)|upper_aerodigestive_tract(1)	7	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			TTACAGTCCAACCTCCCCCAT	0.343000												
CSMD3	114788	broad.mit.edu	37	8	113317004	113317004	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr8:113317004C>T	uc003ynu.2	-	52	8371	c.8212G>A	c.(8212-8214)GAA>AAA	p.E2738K	CSMD3_uc003yns.2_Missense_Mutation_p.E1940K|CSMD3_uc003ynt.2_Missense_Mutation_p.E2698K|CSMD3_uc011lhx.1_Intron	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2738	Extracellular (Potential).|Sushi 16.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGAAGACATTCGATGGAGGCA	0.398000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)		
CSMD3	114788	broad.mit.edu	37	8	113318286	113318286	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr8:113318286C>A	uc003ynu.2	-	51	8180	c.8021G>T	c.(8020-8022)TGC>TTC	p.C2674F	CSMD3_uc003yns.2_Missense_Mutation_p.C1876F|CSMD3_uc003ynt.2_Missense_Mutation_p.C2634F|CSMD3_uc011lhx.1_Missense_Mutation_p.C2570F	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2674	Extracellular (Potential).|Sushi 15.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATCTGATTGGCATACAGCTGT	0.393000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)		
CSMD3	114788	broad.mit.edu	37	8	113323373	113323373	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr8:113323373T>G	uc003ynu.2	-	50	7878	c.7719A>C	c.(7717-7719)GAA>GAC	p.E2573D	CSMD3_uc003yns.2_Missense_Mutation_p.E1775D|CSMD3_uc003ynt.2_Missense_Mutation_p.E2533D|CSMD3_uc011lhx.1_Missense_Mutation_p.E2469D|CSMD3_uc003ynw.1_Missense_Mutation_p.E284D	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2573	Extracellular (Potential).|Sushi 14.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GAGGTGGGGATTCTGGTGTAC	0.398000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)		
ADCY8	114	broad.mit.edu	37	8	132052057	132052057	+	Missense_Mutation	SNP	A	A	C			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr8:132052057A>C	uc003ytd.3	-	1	779	c.523T>G	c.(523-525)TTG>GTG	p.L175V	ADCY8_uc010mds.2_Missense_Mutation_p.L175V	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	175	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CTTTGGCCCAAGAAATAGCGC	0.547000										HNSCC(32;0.087)		
NFKBIL2	4796	broad.mit.edu	37	8	145661049	145661049	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr8:145661049G>A	uc011llg.1	-	17	2782	c.2767C>T	c.(2767-2769)CAG>TAG	p.Q923*	uc011llh.1_Intron	NM_013432	NP_038460	Q96HA7	TONSL_HUMAN	NF-kappa-B inhibitor-like protein 2	923					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			ACCAAGGGCTGGCCTGCCGCA	0.677000												
ADAMTSL1	92949	broad.mit.edu	37	9	18657714	18657714	+	Silent	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr9:18657714G>A	uc003zne.3	+	8	1039	c.912G>A	c.(910-912)ACG>ACA	p.T304T	ADAMTSL1_uc003znb.2_Silent_p.T304T|ADAMTSL1_uc003znc.3_Silent_p.T304T	NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	304						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		GGAGGGAGACGGATTTCTTTC	0.463000												
UNC13B	10497	broad.mit.edu	37	9	35375189	35375189	+	Silent	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr9:35375189C>T	uc003zwq.2	+	13	1651	c.1359C>T	c.(1357-1359)GAC>GAT	p.D453D	UNC13B_uc003zwr.2_Silent_p.D453D	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	453					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			CTCTTAAGGACGAAGAGCTGG	0.498000												
C9orf84	158401	broad.mit.edu	37	9	114462251	114462251	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr9:114462251C>T	uc004bfr.2	-	22	3109	c.2974G>A	c.(2974-2976)GAA>AAA	p.E992K	C9orf84_uc011lwt.1_RNA|C9orf84_uc004bfq.2_Missense_Mutation_p.E953K|C9orf84_uc010mug.2_Missense_Mutation_p.E903K	NM_173521	NP_775792	Q5VXU9	CI084_HUMAN	hypothetical protein LOC158401 isoform 1	992										ovary(2)	2						TCCAGTTCTTCAGAGTTTAGC	0.308000												
RGS3	5998	broad.mit.edu	37	9	116357901	116357901	+	Silent	SNP	C	C	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr9:116357901C>T	uc004bhq.2	+	25	3476	c.3267C>T	c.(3265-3267)GCC>GCT	p.A1089A	RGS3_uc004bhs.2_Silent_p.A979A|RGS3_uc004bht.2_Silent_p.A808A|RGS3_uc010muy.2_Silent_p.A482A|RGS3_uc004bhv.2_Silent_p.A410A|RGS3_uc004bhw.2_Silent_p.A59A|RGS3_uc011lxh.1_Silent_p.A399A|RGS3_uc004bhx.2_Silent_p.A410A|RGS3_uc004bhz.2_Silent_p.A431A|RGS3_uc004bia.2_Silent_p.A202A	NM_144488	NP_652759	P49796	RGS3_HUMAN	regulator of G-protein signalling 3 isoform 6	1089	RGS.				inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3						TGTTCCAAGCCTTCCTTCGCA	0.527000												
SARDH	1757	broad.mit.edu	37	9	136596596	136596596	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr9:136596596G>A	uc004cep.3	-	4	655	c.521C>T	c.(520-522)GCG>GTG	p.A174V	SARDH_uc004ceo.2_Missense_Mutation_p.A174V|SARDH_uc011mdn.1_Missense_Mutation_p.A174V|SARDH_uc011mdo.1_Missense_Mutation_p.A6V	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	174					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		CACACCATACGCCTTGCCCAG	0.632000												
TAF9B	51616	broad.mit.edu	37	X	77393257	77393257	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chrX:77393257A>T	uc004eda.2	-	4	465	c.394T>A	c.(394-396)TTA>ATA	p.L132I		NM_015975	NP_057059	Q9HBM6	TAF9B_HUMAN	transcription associated factor 9B	132					negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell growth|transcription initiation, DNA-dependent	transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding				0						TTTTTAATTAAGGACTTCAGC	0.363000												
CLIP3	25999	broad.mit.edu	37	19	36515298	36515300	+	Splice_Site	DEL	CTT	CTT	-			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr19:36515297_36515299CCTT>C	uc010eeq.2	-	6	1232	c.918_splice	c.e6+1	p.K306_splice	BC071809_uc002ocy.3_Intron|CLIP3_uc002ocz.2_Splice_Site_p.K306_splice	NM_001199570	NP_001186499	Q96DZ5	CLIP3_HUMAN	Homo sapiens CAP-GLY domain containing linker protein 3 (CLIP3), transcript variant 1, mRNA.	306					chaperone-mediated protein transport|fat cell differentiation|membrane biogenesis|negative regulation of microtubule polymerization|peptidyl-L-cysteine S-palmitoylation|positive regulation of apoptosis|positive regulation of endocytosis|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose transport|positive regulation of protein phosphorylation	Golgi stack|early endosome membrane|membrane raft|microsome|plasma membrane|recycling endosome membrane|trans-Golgi network membrane	ganglioside binding|microtubule binding			cervix(1)|endometrium(6)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	23	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CAGCCCCTGACCTTCTGGCCATC	0.621												
CLIP3	25999	broad.mit.edu	37	19	36515298	36515300	+	Splice_Site	DEL	CTT	CTT	-			TCGA-BR-6457-01A-21D-1800-08	TCGA-BR-6457-10A-01D-1800-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a79bb4ec-4479-4a1f-97c6-fe1b0a99c2f6	b862ca4f-f9c3-4a54-9af8-11128af80cc4	g.chr19:36515297_36515299CCTT>C	uc010eeq.2	-	6	1232	c.918_splice	c.e6+1	p.K306_splice	BC071809_uc002ocy.3_Intron|CLIP3_uc002ocz.2_Splice_Site_p.K306_splice	NM_001199570	NP_001186499	Q96DZ5	CLIP3_HUMAN	Homo sapiens CAP-GLY domain containing linker protein 3 (CLIP3), transcript variant 1, mRNA.	306					chaperone-mediated protein transport|fat cell differentiation|membrane biogenesis|negative regulation of microtubule polymerization|peptidyl-L-cysteine S-palmitoylation|positive regulation of apoptosis|positive regulation of endocytosis|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose transport|positive regulation of protein phosphorylation	Golgi stack|early endosome membrane|membrane raft|microsome|plasma membrane|recycling endosome membrane|trans-Golgi network membrane	ganglioside binding|microtubule binding			cervix(1)|endometrium(6)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	23	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CAGCCCCTGACCTTCTGGCCATC	0.621												
