Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
PLEKHG5	57449	broad.mit.edu	37	1	6534204	6534204	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:6534204C>G	uc001ano.1	-	8	729	c.628G>C	c.(628-630)GAG>CAG	p.E210Q	PLEKHG5_uc001ann.1_Missense_Mutation_p.E191Q|PLEKHG5_uc001anq.1_Missense_Mutation_p.E231Q|PLEKHG5_uc001anp.1_Missense_Mutation_p.E231Q|PLEKHG5_uc001anj.1_5'Flank|PLEKHG5_uc009vma.1_5'UTR|PLEKHG5_uc010nzr.1_Missense_Mutation_p.E223Q|PLEKHG5_uc001ank.1_Missense_Mutation_p.E154Q|PLEKHG5_uc009vmb.1_Missense_Mutation_p.E154Q|PLEKHG5_uc001anl.1_Missense_Mutation_p.E154Q|PLEKHG5_uc001anm.1_Missense_Mutation_p.E154Q	NM_001042663	NP_001036128	O94827	PKHG5_HUMAN	pleckstrin homology domain containing family G	210					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		ACCTTGCCCTCATCTCCAGGC	0.677		NaN											0	0	0	0.013537	0	9	35									
TARDBP	23435	broad.mit.edu	37	1	11082686	11082686	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:11082686C>G	uc001art.2	+	6	1354	c.1220C>G	c.(1219-1221)TCT>TGT	p.S407C	TARDBP_uc010oap.1_Missense_Mutation_p.S291C	NM_007375	NP_031401	Q13148	TADBP_HUMAN	TAR DNA binding protein	407	Gly-rich.				3'-UTR-mediated mRNA stabilization|cell death|mRNA processing|negative regulation by host of viral transcription|RNA splicing|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0578)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.37e-07)|COAD - Colon adenocarcinoma(227;7.38e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)		AGCATGGATTCTAAGTCTTCT	0.443		NaN											0	0	0	0.007835	0	26	146									
DNAJC16	23341	broad.mit.edu	37	1	15871058	15871058	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:15871058C>A	uc001aws.2	+	5	859	c.739C>A	c.(739-741)CCA>ACA	p.P247T	DNAJC16_uc001awr.1_Missense_Mutation_p.P247T|DNAJC16_uc001awt.2_5'UTR	NM_015291	NP_056106	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	247	Cytoplasmic (Potential).|Thioredoxin.				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			urinary_tract(1)|lung(1)|kidney(1)	3		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		AAGTCTTCTTCCAGGGAACTT	0.423		NaN											1	0	3.7963e-18	0.00333	4.28924e-18	19	89									
DNAJC16	23341	broad.mit.edu	37	1	15890809	15890809	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:15890809C>G	uc001aws.2	+	11	1673	c.1553C>G	c.(1552-1554)TCT>TGT	p.S518C	DNAJC16_uc001awr.1_Missense_Mutation_p.S518C|DNAJC16_uc001awt.2_Missense_Mutation_p.S206C|DNAJC16_uc001awu.2_RNA	NM_015291	NP_056106	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	518	Cytoplasmic (Potential).				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			urinary_tract(1)|lung(1)|kidney(1)	3		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		TACTCTGCTTCTGACTACATC	0.433		NaN											0	0	0	0.004289	0	28	130									
KDM1A	23028	broad.mit.edu	37	1	23395118	23395118	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:23395118C>T	uc001bgi.2	+	9	1343	c.1194C>T	c.(1192-1194)TTC>TTT	p.F398F	KDM1A_uc001bgj.2_Silent_p.F422F	NM_015013	NP_055828	O60341	KDM1A_HUMAN	lysine-specific histone demethylase 1 isoform b	398	Demethylase activity.				blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2						AACTAGACTTCAATGTCCTCA	0.398		NaN											0	0	0	0.007413	0	18	28									
GJB3	2707	broad.mit.edu	37	1	35250591	35250591	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:35250591C>T	uc001bxx.2	+	2	843	c.228C>T	c.(226-228)CTC>CTT	p.L76L	GJB3_uc001bxy.2_Silent_p.L76L|GJB3_uc001bxz.3_Silent_p.L76L|uc010ohs.1_RNA	NM_024009	NP_076872	O75712	CXB3_HUMAN	connexin 31	76	Helical; (Potential).				cell communication	connexon complex|integral to membrane	gap junction channel activity				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				ACATCCGCCTCTGGGCCCTGC	0.622		NaN											0	0	0	0.010729	0	12	22									
ZMYM4	9202	broad.mit.edu	37	1	35885249	35885249	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:35885249G>C	uc001byt.2	+	30	4698	c.4618G>C	c.(4618-4620)GAA>CAA	p.E1540Q	ZMYM4_uc009vuu.2_Missense_Mutation_p.E1508Q|ZMYM4_uc001byu.2_Missense_Mutation_p.E1216Q|ZMYM4_uc009vuv.2_Missense_Mutation_p.E1279Q	NM_005095	NP_005086	Q5VZL5	ZMYM4_HUMAN	zinc finger protein 262	1540					multicellular organismal development		DNA binding|zinc ion binding			large_intestine(2)|ovary(1)|kidney(1)|skin(1)	5		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AGCCAAATCTGAAGACTCTGA	0.423		NaN											0	0	0	0.001855	0	12	32									
MTF1	4520	broad.mit.edu	37	1	38304297	38304297	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:38304297C>T	uc001cce.1	-	4	920	c.779G>A	c.(778-780)CGG>CAG	p.R260Q	MTF1_uc009vvj.1_5'UTR	NM_005955	NP_005946	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	260	C2H2-type 5.					nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			ovary(1)|pancreas(1)	2	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TAAGACCTACCGAAATGGCTT	0.403		NaN											0	0	0	0.00245	0	11	62									
CAP1	10487	broad.mit.edu	37	1	40529930	40529930	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:40529930C>G	uc001cfa.3	+	5	555	c.326C>G	c.(325-327)TCA>TGA	p.S109*	CAP1_uc001cey.3_Nonsense_Mutation_p.S109*|CAP1_uc001cez.3_Nonsense_Mutation_p.S109*|CAP1_uc009vvz.2_Nonsense_Mutation_p.S109*|CAP1_uc010oje.1_Intron	NM_006367	NP_006358	Q01518	CAP1_HUMAN	adenylyl cyclase-associated protein	109					activation of adenylate cyclase activity|axon guidance|establishment or maintenance of cell polarity|platelet activation|platelet degranulation|signal transduction	plasma membrane	actin binding			ovary(1)	1	Lung NSC(20;5.03e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;4.63e-18)|Epithelial(16;1.27e-16)|all cancers(16;2.3e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GCACCCATCTCAGAGCAGATC	0.448		NaN											0	0	0	0.003954	0	21	66									
TSPAN1	10103	broad.mit.edu	37	1	46651197	46651197	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:46651197C>G	uc001cpd.2	+	9	1182	c.718C>G	c.(718-720)CTA>GTA	p.L240V	TSPAN1_uc009vyd.1_Missense_Mutation_p.L240V	NM_005727	NP_005718	O60635	TSN1_HUMAN	tetraspan 1	240	Cytoplasmic (Potential).					integral to membrane|lysosomal membrane				ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)	Medulloblastoma(700;0.00498)|all_neural(321;0.0212)				GTACTGCAATCTACAATAAGT	0.542		NaN											0	0	0	0.01441	0	46	236									
CC2D1B	200014	broad.mit.edu	37	1	52824767	52824767	+	Missense_Mutation	SNP	C	C	G	rs144724390	byFrequency	TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:52824767C>G	uc001ctq.1	-	11	1327	c.1189G>C	c.(1189-1191)GAG>CAG	p.E397Q	CC2D1B_uc001ctr.2_5'Flank|CC2D1B_uc001cts.2_Missense_Mutation_p.E88Q	NM_032449	NP_115825	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	397										ovary(2)	2						ATGCCCGCCTCGCGGTACTTG	0.632		NaN											0	0	0	0.006214	0	8	37									
CC2D1B	200014	broad.mit.edu	37	1	52825538	52825538	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:52825538C>G	uc001ctq.1	-	8	919	c.781G>C	c.(781-783)GAG>CAG	p.E261Q	CC2D1B_uc001ctr.2_5'Flank|CC2D1B_uc001cts.2_5'UTR	NM_032449	NP_115825	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	261	Pro-rich.									ovary(2)	2						AGGCTGGTCTCAGGTTGGGAG	0.572		NaN											0	0	0	0.009096	0	3	19									
AK3L1	205	broad.mit.edu	37	1	65684501	65684501	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:65684501C>G	uc001dby.2	+	4	577	c.330C>G	c.(328-330)ATC>ATG	p.I110M	AK3L1_uc009wan.2_Missense_Mutation_p.I58M|AK3L1_uc001dbz.2_Missense_Mutation_p.I110M|AK3L1_uc001dca.2_Missense_Mutation_p.I110M	NM_203464	NP_982289	P27144	KAD4_HUMAN	adenylate kinase 3-like 1 isoform 7	110						mitochondrial matrix	adenylate kinase activity|ATP binding|GTP binding				0						ATCTAGTGATCAGTTTGAATA	0.433		NaN											0	0	0	0.004482	0	5	47									
C1orf173	127254	broad.mit.edu	37	1	75065450	75065450	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:75065450G>A	uc001dgg.2	-	11	1874	c.1655C>T	c.(1654-1656)CCA>CTA	p.P552L	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Missense_Mutation_p.P346L	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	552	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						ACGGGCATCTGGTGCCTTCTG	0.408		NaN											0	0	0	0.009718	0	43	102									
ZZZ3	26009	broad.mit.edu	37	1	78034131	78034131	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:78034131G>C	uc001dhq.2	-	13	2828	c.2352C>G	c.(2350-2352)ATC>ATG	p.I784M	ZZZ3_uc001dhr.2_Missense_Mutation_p.I290M|ZZZ3_uc001dhp.2_Missense_Mutation_p.I783M	NM_015534	NP_056349	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	784					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|large_intestine(1)	5						TCCTATACATGATAGGAATAC	0.269		NaN											0	0	0	0.010729	0	12	11									
USP33	23032	broad.mit.edu	37	1	78187599	78187599	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:78187599G>A	uc001dht.2	-	15	2014	c.1667C>T	c.(1666-1668)TCA>TTA	p.S556L	USP33_uc001dhs.2_Missense_Mutation_p.S277L|USP33_uc001dhu.2_Missense_Mutation_p.S525L|USP33_uc001dhv.2_Missense_Mutation_p.S361L|USP33_uc001dhw.2_Intron	NM_015017	NP_055832	Q8TEY7	UBP33_HUMAN	ubiquitin specific protease 33 isoform 1	556					axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(2)|ovary(1)	3						AGGGACACATGAGACAACAAA	0.373		NaN											0	0	0	0.003163	0	14	29									
LPAR3	23566	broad.mit.edu	37	1	85279670	85279670	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:85279670C>G	uc001dkl.2	-	2	960	c.921G>C	c.(919-921)ATG>ATC	p.M307I	LPAR3_uc009wcj.1_Missense_Mutation_p.M307I	NM_012152	NP_036284	Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	307	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				lung(3)|ovary(2)	5						AGCAGCAGATCATCTTCTTCA	0.547		NaN											0	0	0	0.007413	0	16	64									
SH3GLB1	51100	broad.mit.edu	37	1	87208005	87208005	+	Silent	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:87208005C>A	uc001dlw.2	+	8	1202	c.876C>A	c.(874-876)ATC>ATA	p.I292I	SH3GLB1_uc001dlx.2_Silent_p.I313I|SH3GLB1_uc001dly.2_Silent_p.I321I|SH3GLB1_uc001dlz.2_Silent_p.I192I	NM_016009	NP_057093	Q9Y371	SHLB1_HUMAN	SH3-containing protein SH3GLB1	292					anti-apoptosis|filopodium assembly|signal transduction	Golgi membrane|mitochondrial outer membrane	cytoskeletal adaptor activity|protein homodimerization activity|SH3 domain binding				0		Lung NSC(277;0.209)		all cancers(265;0.0136)|Epithelial(280;0.0414)		GCCTAGTAATCACCTCTCCTT	0.438		NaN											1	0	1.30015e-28	0.004878	1.51295e-28	36	47									
LRRC8D	55144	broad.mit.edu	37	1	90400866	90400866	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:90400866G>C	uc001dnm.2	+	3	2664	c.2239G>C	c.(2239-2241)GAA>CAA	p.E747Q	LRRC8D_uc001dnn.2_Missense_Mutation_p.E747Q	NM_001134479	NP_001127951	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member	747	LRR 10.					integral to membrane	protein binding			ovary(2)	2		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)		GATTCCAATAGAAATAGGATT	0.373		NaN											0	0	0	0.007413	0	19	73									
BARHL2	343472	broad.mit.edu	37	1	91182500	91182500	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:91182500G>A	uc001dns.2	-	1	295	c.253C>T	c.(253-255)CAT>TAT	p.H85Y		NM_020063	NP_064447	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	85						nucleus	sequence-specific DNA binding			ovary(1)	1		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		AGGTGGTGATGATGCTGGGTC	0.473		NaN											0	0	0	0.008291	0	10	16									
GCLM	2730	broad.mit.edu	37	1	94360257	94360257	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:94360257G>A	uc001dqg.1	-	6	861	c.568C>T	c.(568-570)CTT>TTT	p.L190F		NM_002061	NP_002052	P48507	GSH0_HUMAN	glutamate-cysteine ligase regulatory protein	190					glutamate metabolic process|glutathione biosynthetic process|regulation of blood vessel size|response to drug|response to oxidative stress|xenobiotic metabolic process	cytosol|soluble fraction	glutamate-cysteine ligase catalytic subunit binding			ovary(1)	1		all_lung(203;0.000815)|Lung NSC(277;0.00363)		all cancers(265;0.00566)|GBM - Glioblastoma multiforme(16;0.0203)|Epithelial(280;0.131)	L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	CAGGAGGCAAGATTAACTTGG	0.323		NaN											0	0	0	0.01441	0	51	87									
CSDE1	7812	broad.mit.edu	37	1	115262243	115262243	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:115262243G>A	uc001efk.2	-	18	2639	c.2173C>T	c.(2173-2175)CAG>TAG	p.Q725*	NRAS_uc009wgu.2_5'Flank|CSDE1_uc001efi.2_Nonsense_Mutation_p.Q771*|CSDE1_uc001efj.2_RNA|CSDE1_uc001efl.2_Nonsense_Mutation_p.Q694*|CSDE1_uc001efm.2_Nonsense_Mutation_p.Q740*|CSDE1_uc009wgv.2_Nonsense_Mutation_p.Q725*|CSDE1_uc001efn.2_Nonsense_Mutation_p.Q694*	NM_001007553	NP_001007554	O75534	CSDE1_HUMAN	upstream of NRAS isoform 1	725	CSD 9.				male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			ovary(1)	1	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCAGTGCGCTGATTAAGAATC	0.448		NaN											0	0	0	0.005443	0	24	101									
NBPF10	100132406	broad.mit.edu	37	1	145301812	145301812	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:145301812G>A	uc001end.3	+	7	1116	c.1081G>A	c.(1081-1083)GAG>AAG	p.E361K	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Missense_Mutation_p.E361K|NBPF10_uc010oyi.1_5'Flank|NBPF10_uc001emq.1_Missense_Mutation_p.E90K	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	361											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		CAAGCAAGCTGAGGAGCTCAG	0.522		NaN											0	0	0	0.003954	0	9	179									
FMO5	2330	broad.mit.edu	37	1	146672879	146672879	+	Silent	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:146672879G>C	uc001epi.2	-	7	1427	c.1038C>G	c.(1036-1038)GTC>GTG	p.V346V	FMO5_uc001eph.3_Silent_p.V346V|FMO5_uc001epj.2_Intron	NM_001461	NP_001452	P49326	FMO5_HUMAN	flavin containing monooxygenase 5 isoform 1	346						integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			ovary(3)	3	all_hematologic(923;0.0487)					TCTTGTTTTTGACCACTTTGA	0.443		NaN											0	0	0	0.001984	0	6	68									
BCL9	607	broad.mit.edu	37	1	147092562	147092562	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:147092562G>A	uc001epq.2	+	8	3341	c.2601G>A	c.(2599-2601)ACG>ACA	p.T867T	BCL9_uc010ozr.1_Silent_p.T793T	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	867	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					AGTCTCCCACGATGCACCAAG	0.637		NaN	T	IGH@|IGL@	B-ALL								0	0	0	0.003954	0	23	97									
HORMAD1	84072	broad.mit.edu	37	1	150687152	150687152	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:150687152G>A	uc001evk.1	-	4	287	c.181C>T	c.(181-183)CTT>TTT	p.L61F	HORMAD1_uc001evl.1_Missense_Mutation_p.L61F|HORMAD1_uc001evm.1_Intron	NM_032132	NP_115508	Q86X24	HORM1_HUMAN	HORMA domain containing 1	61	HORMA.				blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			TTGACACAAAGATCTAAACAC	0.174		NaN											0	0	0	0.007413	0	14	59									
SETDB1	9869	broad.mit.edu	37	1	150923439	150923439	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:150923439G>C	uc001evu.2	+	13	2276	c.2086G>C	c.(2086-2088)GAG>CAG	p.E696Q	SETDB1_uc009wmf.2_Missense_Mutation_p.E697Q|SETDB1_uc001evv.2_Missense_Mutation_p.E696Q|SETDB1_uc009wmg.1_Missense_Mutation_p.E696Q	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	696					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTGTGTCAATGAGATTGACAC	0.468		NaN											0	0	0	0.00333	0	16	75									
PRUNE	58497	broad.mit.edu	37	1	151001306	151001306	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:151001306C>G	uc001ewh.1	+	7	955	c.819C>G	c.(817-819)TTC>TTG	p.F273L	PRUNE_uc001ewi.1_Missense_Mutation_p.F91L|PRUNE_uc010pco.1_Missense_Mutation_p.F41L|PRUNE_uc001ewj.1_Intron|PRUNE_uc001ewk.1_Intron	NM_021222	NP_067045	Q86TP1	PRUNE_HUMAN	prune	273						cytoplasm|focal adhesion|nucleus	inorganic diphosphatase activity|manganese ion binding|protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCCATGCTTTCTGCCAGGCTC	0.478		NaN											0	0	0	0.010504	0	16	109									
TCHH	7062	broad.mit.edu	37	1	152081239	152081239	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:152081239C>G	uc001ezp.2	-	2	4454	c.4454G>C	c.(4453-4455)AGA>ACA	p.R1485T	TCHH_uc009wne.1_Missense_Mutation_p.R1485T	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1485	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAGGAATTTTCTGTCACGCTC	0.552		NaN											0	0	0	0.01441	0	44	147									
INTS3	65123	broad.mit.edu	37	1	153713793	153713793	+	Silent	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:153713793C>A	uc009wom.2	+	4	488	c.267C>A	c.(265-267)ATC>ATA	p.I89I	INTS3_uc001fct.2_Silent_p.I89I|INTS3_uc001fcu.2_Translation_Start_Site|INTS3_uc001fcv.2_Translation_Start_Site	NM_023015	NP_075391	Q68E01	INT3_HUMAN	integrator complex subunit 3	89					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			ATGAAGAAATCTGCCTGGGCC	0.493		NaN											1	0	5.35047e-06	0.00333	5.57022e-06	18	169									
KCNN3	3782	broad.mit.edu	37	1	154841844	154841844	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:154841844G>C	uc001ffp.2	-	1	911	c.597C>G	c.(595-597)ATC>ATG	p.I199M	KCNN3_uc009wox.1_Missense_Mutation_p.I199M	NM_002249	NP_002240	Q9UGI6	KCNN3_HUMAN	small conductance calcium-activated potassium	204						integral to membrane	calmodulin binding			lung(1)	1	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			TCTCGGCCTCGATGAGGTTCC	0.637		NaN											0	0	0	0.004482	0	7	61									
PAQR6	79957	broad.mit.edu	37	1	156215947	156215947	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:156215947G>A	uc001fnu.1	-	3	216	c.146C>T	c.(145-147)ACG>ATG	p.T49M	PAQR6_uc010phf.1_Translation_Start_Site|PAQR6_uc001fny.1_Translation_Start_Site|PAQR6_uc001fnv.1_Missense_Mutation_p.T25M|PAQR6_uc010phg.1_Missense_Mutation_p.T46M|PAQR6_uc001fnx.1_Translation_Start_Site|PAQR6_uc001fnw.1_Translation_Start_Site|PAQR6_uc001fnz.1_Translation_Start_Site|PAQR6_uc010phh.1_Missense_Mutation_p.T49M|PAQR6_uc001foa.1_Translation_Start_Site|PAQR6_uc001fob.1_RNA	NM_198406	NP_940798	Q6TCH4	PAQR6_HUMAN	progestin and adipoQ receptor family member VI	49	Cytoplasmic (Potential).					integral to membrane	receptor activity				0	Hepatocellular(266;0.158)					GATGTTGACCGTCTCGTTGGT	0.647		NaN											0	0	0	0.004656	0	23	43									
SMG5	23381	broad.mit.edu	37	1	156237348	156237348	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:156237348C>G	uc001foc.3	-	10	1179	c.1030G>C	c.(1030-1032)GAG>CAG	p.E344Q	SMG5_uc009wrv.2_5'Flank	NM_015327	NP_056142	Q9UPR3	SMG5_HUMAN	SMG5 homolog nonsense mediated mRNA decay	344					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			ovary(2)|skin(2)|pancreas(1)	5	Hepatocellular(266;0.158)					TATCCACTCTCATACTCCTCC	0.527		NaN											0	0	0	0.010729	0	9	91									
C1orf61	10485	broad.mit.edu	37	1	156386657	156386657	+	Splice_Site	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:156386657C>G	uc001fou.1	-	3	93	c.-24_splice	c.e3-1		C1orf61_uc001fov.1_Intron|C1orf61_uc001fow.1_Intron|C1orf61_uc001fox.1_Intron|C1orf61_uc001foy.1_Intron	NM_006365	NP_006356	Q13536	CROC4_HUMAN	transcriptional activator of the c-fos promoter							nucleus				skin(1)	1	Hepatocellular(266;0.158)					TTTTTACATTCTGAAACAAAT	0.388		NaN											0	0	0	0.00245	0	13	35									
BCAN	63827	broad.mit.edu	37	1	156617355	156617355	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:156617355G>A	uc001fpp.2	+	4	858	c.522G>A	c.(520-522)GGG>GGA	p.G174G	BCAN_uc001fpo.2_Silent_p.G174G	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	174	Link 1.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CCTTTTCTGGGGCCCAGGAGG	0.642		NaN											0	0	0	0.004007	0	13	35									
NES	10763	broad.mit.edu	37	1	156640696	156640696	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:156640696G>A	uc001fpq.2	-	4	3417	c.3284C>T	c.(3283-3285)GCG>GTG	p.A1095V		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	1095	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTCAGCTCCCGCAGCAGACTC	0.662		NaN											0	0	0	0.00499	0	17	44									
OR6K6	128371	broad.mit.edu	37	1	158724899	158724899	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:158724899G>A	uc001fsw.1	+	1	294	c.294G>A	c.(292-294)GAG>GAA	p.E98E		NM_001005184	NP_001005184	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K,	98	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_hematologic(112;0.0378)					CCTTCCTGGAGATCTGCTATA	0.483		NaN											0	0	0	0.01441	0	58	177									
ATP1A2	477	broad.mit.edu	37	1	160098495	160098495	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:160098495G>A	uc001fvc.2	+	9	1203	c.1071G>A	c.(1069-1071)AAG>AAA	p.K357K	ATP1A2_uc001fvb.2_Silent_p.K357K|ATP1A2_uc010piz.1_Silent_p.K202K|ATP1A2_uc001fvd.2_Silent_p.K93K|ATP1A2_uc009wtg.1_Silent_p.K45K	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	357	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			GCCTGGTGAAGAACCTGGAGG	0.592		NaN											0	0	0	0.003755	0	29	97									
RXRG	6258	broad.mit.edu	37	1	165370572	165370572	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:165370572G>C	uc001gda.2	-	10	1620	c.1320C>G	c.(1318-1320)TTC>TTG	p.F440L		NM_006917	NP_008848	P48443	RXRG_HUMAN	retinoid X receptor, gamma isoform a	440	Ligand-binding (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	CGATGAGCTTGAAGAAGAAGA	0.597		NaN											0	0	0	0.01441	0	49	98									
DPT	1805	broad.mit.edu	37	1	168665804	168665804	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:168665804C>T	uc001gfp.2	-	4	605	c.589G>A	c.(589-591)GAA>AAA	p.E197K		NM_001937	NP_001928	Q07507	DERM_HUMAN	dermatopontin precursor	197					cell adhesion	extracellular space|proteinaceous extracellular matrix				ovary(1)	1	all_hematologic(923;0.208)					TTTGCAAATTCACAGTCGTAT	0.473		NaN											0	0	0	0.008291	0	9	61									
KIFAP3	22920	broad.mit.edu	37	1	169930298	169930298	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:169930298C>G	uc001ggv.2	-	18	2333	c.2062G>C	c.(2062-2064)GAG>CAG	p.E688Q	KIFAP3_uc010plx.1_Missense_Mutation_p.E390Q	NM_014970	NP_055785	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	688					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGACGACTCTCTACCATCTCC	0.408		NaN											0	0	0	0.01441	0	63	83									
PRRX1	5396	broad.mit.edu	37	1	170633362	170633362	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:170633362G>A	uc001ghf.2	+	1	50	c.3G>A	c.(1-3)ATG>ATA	p.M1I	PRRX1_uc001ghe.2_Missense_Mutation_p.M1I	NM_022716	NP_073207	P54821	PRRX1_HUMAN	paired mesoderm homeobox 1 isoform pmx-1b	1						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GGGAGACCATGACCTCCAGCT	0.657		NaN											0	0	0	0.009096	0	4	13									
LHX4	89884	broad.mit.edu	37	1	180241097	180241097	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:180241097C>G	uc001goe.1	+	5	957	c.734C>G	c.(733-735)TCT>TGT	p.S245C	uc001gof.1_RNA	NM_033343	NP_203129	Q969G2	LHX4_HUMAN	LIM homeobox protein 4	245						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						AAGGAGAGCTCTGCAGAGGAC	0.617		NaN											0	0	0	0.001984	0	5	44									
FAM5C	339479	broad.mit.edu	37	1	190195374	190195374	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:190195374A>T	uc001gse.1	-	6	1031	c.799T>A	c.(799-801)TCA>ACA	p.S267T	FAM5C_uc010pot.1_Missense_Mutation_p.S165T	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	267						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					TCTCCCTCTGAATTGCAAGCA	0.438		NaN											0	0	0	0.00333	0	19	60									
ADIPOR1	51094	broad.mit.edu	37	1	202920093	202920093	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:202920093C>G	uc001gyq.3	-	2	373	c.106G>C	c.(106-108)GAG>CAG	p.E36Q	ADIPOR1_uc010pqd.1_5'Flank|ADIPOR1_uc001gyr.3_5'UTR|ADIPOR1_uc001gys.3_Missense_Mutation_p.E36Q	NM_015999	NP_057083	Q96A54	ADR1_HUMAN	adiponectin receptor 1	36	Cytoplasmic (Potential).				fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane|plasma membrane	hormone binding|protein kinase binding|receptor activity				0			BRCA - Breast invasive adenocarcinoma(75;0.141)			TTGCCCTTCTCTTCTAGCAGG	0.527		NaN											0	0	0	0.006122	0	16	148									
CHIT1	1118	broad.mit.edu	37	1	203192738	203192738	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:203192738G>C	uc001gzn.2	-	5	461	c.365C>G	c.(364-366)TCG>TGG	p.S122W	FMOD_uc010pqi.1_Intron|CHIT1_uc001gzm.1_RNA|CHIT1_uc009xal.1_5'Flank|CHIT1_uc009xam.1_RNA|CHIT1_uc009xan.1_RNA|CHIT1_uc001gzo.2_Missense_Mutation_p.S113W	NM_003465	NP_003456	Q13231	CHIT1_HUMAN	chitotriosidase precursor	122					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity				0						CCTGATGGCCGAGTTGACAAA	0.577		NaN											0	0	0	0.005443	0	22	180									
ATP2B4	493	broad.mit.edu	37	1	203680026	203680026	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:203680026G>A	uc001gzw.2	+	12	2705	c.1821G>A	c.(1819-1821)CGG>CGA	p.R607R	ATP2B4_uc001gzv.2_Silent_p.R607R|ATP2B4_uc009xaq.2_Silent_p.R607R	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	607	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TCCTGGACCGGAAAGGGGAAG	0.502		NaN											0	0	0	0.003163	0	15	24									
REN	5972	broad.mit.edu	37	1	204135397	204135397	+	Missense_Mutation	SNP	G	G	A	rs115181548	by1000genomes	TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:204135397G>A	uc001haq.2	-	1	69	c.25C>T	c.(25-27)CGC>TGC	p.R9C		NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	9					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	AGTCCCCAGCGAGGCATCCTT	0.557		NaN											0	0	0	0.003163	0	13	78									
SLC26A9	115019	broad.mit.edu	37	1	205896660	205896660	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:205896660G>C	uc001hdq.2	-	10	1289	c.1175C>G	c.(1174-1176)TCT>TGT	p.S392C	SLC26A9_uc001hdo.2_Missense_Mutation_p.S60C|SLC26A9_uc001hdp.2_Missense_Mutation_p.S392C	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	392	Helical; (Potential).					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			CAGAGTGACAGAAAGCGCACA	0.517		NaN											0	0	0	0.010729	0	11	45									
C1orf107	27042	broad.mit.edu	37	1	210014333	210014333	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:210014333C>G	uc001hhr.1	+	8	1494	c.1418C>G	c.(1417-1419)TCT>TGT	p.S473C	C1orf107_uc009xcu.1_Missense_Mutation_p.S188C	NM_014388	NP_055203	Q68CQ4	DIEXF_HUMAN	digestive-organ expansion factor homolog	473					multicellular organismal development	nucleus					0				OV - Ovarian serous cystadenocarcinoma(81;0.0367)		GACTTTCTGTCTTCTATCGAG	0.483		NaN											0	0	0	0.004656	0	24	96									
INTS7	25896	broad.mit.edu	37	1	212190334	212190334	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:212190334C>T	uc001hiw.1	-	4	508	c.403G>A	c.(403-405)GAG>AAG	p.E135K	INTS7_uc009xdb.1_Missense_Mutation_p.E135K|INTS7_uc001hix.1_Missense_Mutation_p.E11K|INTS7_uc001hiy.1_Missense_Mutation_p.E135K|INTS7_uc010pta.1_Missense_Mutation_p.E86K	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	135					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		TTCTTCCTCTCAGGAATTATT	0.398		NaN											0	0	0	0.013114	0	32	123									
CENPF	1063	broad.mit.edu	37	1	214815002	214815002	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:214815002G>A	uc001hkm.2	+	12	3495	c.3321G>A	c.(3319-3321)CAG>CAA	p.Q1107Q		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	1107	Potential.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		AGACAGTGCAGCAAGCTCTGA	0.373		NaN											0	0	0	0.000602	0	3	115									
TP53BP2	7159	broad.mit.edu	37	1	223983678	223983678	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:223983678C>T	uc010pvb.1	-	13	2855	c.2563G>A	c.(2563-2565)GAA>AAA	p.E855K	TP53BP2_uc001hod.2_Missense_Mutation_p.E726K|TP53BP2_uc010puz.1_Missense_Mutation_p.E88K|TP53BP2_uc010pva.1_Missense_Mutation_p.E494K	NM_001031685	NP_001026855	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2 isoform 1	849	Pro-rich.				apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)		TTTGGTTCTTCTGGGTTATTC	0.547		NaN											0	0	0	0.007413	0	15	89									
RYR2	6262	broad.mit.edu	37	1	237806646	237806646	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:237806646G>C	uc001hyl.1	+	48	7361	c.7241G>C	c.(7240-7242)GGA>GCA	p.G2414A		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2414	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GCCGGGAAGGGAGAAGCCATC	0.413		NaN											0	0	0	0.01441	0	37	139									
OR2L13	284521	broad.mit.edu	37	1	248263467	248263467	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:248263467C>T	uc001ids.2	+	3	1127	c.790C>T	c.(790-792)CTC>TTC	p.L264F		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	264	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			GCCCAGGAATCTCCGCTCACC	0.468		NaN											0	0	0	0.011902	0	37	88									
ZNF672	79894	broad.mit.edu	37	1	249142668	249142668	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:249142668G>C	uc001iex.2	+	4	1890	c.1195G>C	c.(1195-1197)GAG>CAG	p.E399Q		NM_024836	NP_079112	Q499Z4	ZN672_HUMAN	zinc finger protein 672	399	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			GGAGTGCGCAGAGTGCGGCAA	0.682		NaN											0	0	0	0.001168	0	6	10									
ANKRD16	54522	broad.mit.edu	37	10	5925115	5925115	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:5925115C>T	uc010qat.1	-	5	1246	c.703G>A	c.(703-705)GAA>AAA	p.E235K	ANKRD16_uc009xie.2_Missense_Mutation_p.E235K|ANKRD16_uc009xif.2_Missense_Mutation_p.E235K|ANKRD16_uc001iiq.2_Missense_Mutation_p.E235K	NM_019046	NP_061919	Q6P6B7	ANR16_HUMAN	ankyrin repeat domain 16 isoform a	235											0						AGGCTGTCTTCTGCTGAAAGG	0.542		NaN											0	0	0	0.006214	0	6	31									
FBXO18	84893	broad.mit.edu	37	10	5945065	5945065	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:5945065C>A	uc001iis.2	+	2	179	c.84C>A	c.(82-84)TTC>TTA	p.F28L	FBXO18_uc001iir.2_5'UTR|FBXO18_uc009xig.2_5'UTR|FBXO18_uc001iit.2_Missense_Mutation_p.F79L	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	28					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						CCCAGCCCTTCGGTCAAAGAT	0.488		NaN											1	0	1.99505e-19	0.012213	2.28062e-19	26	40									
TRDMT1	1787	broad.mit.edu	37	10	17195630	17195630	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:17195630C>G	uc001iop.2	-	10	999	c.951G>C	c.(949-951)GAG>GAC	p.E317D	TRDMT1_uc001ioq.2_Missense_Mutation_p.E293D|TRDMT1_uc001ior.2_Missense_Mutation_p.E271D|TRDMT1_uc001ios.2_Missense_Mutation_p.E246D|TRDMT1_uc009xjt.2_Missense_Mutation_p.E236D|TRDMT1_uc010qcc.1_Missense_Mutation_p.E246D|TRDMT1_uc010qcd.1_Missense_Mutation_p.E194D	NM_004412	NP_004403	O14717	TRDMT_HUMAN	tRNA aspartic acid methyltransferase 1 isoform	317					tRNA processing	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|RNA binding			ovary(1)	1						TGTAGATATTCTCAACCTGTA	0.333		NaN											0	0	0	0.001168	0	4	18									
MLLT10	8028	broad.mit.edu	37	10	21962735	21962735	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:21962735C>G	uc001iqs.2	+	11	1856	c.1508C>G	c.(1507-1509)TCT>TGT	p.S503C	MLLT10_uc001iqt.2_Missense_Mutation_p.S503C|MLLT10_uc001iqv.2_RNA|MLLT10_uc001iqy.2_Missense_Mutation_p.S503C|MLLT10_uc001ira.2_Translation_Start_Site|MLLT10_uc001irb.2_RNA|MLLT10_uc001iqz.2_Missense_Mutation_p.S258C	NM_004641	NP_004632	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	503	DNA-binding.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(1)|skin(1)	2						CCAACATCATCTGTAGCATCA	0.433		NaN	T	MLL|PICALM|CDK6	AL								0	0	0	0.008361	0	27	76									
RBP3	5949	broad.mit.edu	37	10	48389845	48389845	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:48389845C>T	uc001jez.2	-	1	1147	c.1033G>A	c.(1033-1035)GAC>AAC	p.D345N		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	345	4 X approximate tandem repeats.|2.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	GGCACACGGTCCACCAGCGTG	0.637		NaN											0	0	0	0.010729	0	11	53									
OGDHL	55753	broad.mit.edu	37	10	50966537	50966537	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:50966537G>A	uc001jie.2	-	2	244	c.102C>T	c.(100-102)TCC>TCT	p.S34S	OGDHL_uc009xog.2_Silent_p.S61S|OGDHL_uc010qgt.1_Silent_p.S34S|OGDHL_uc010qgu.1_Intron|OGDHL_uc009xoh.2_Intron	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	34					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						CCGGTGGCCCGGAGGACCTGC	0.632		NaN											0	0	0	0.007413	0	17	27									
LRRTM3	347731	broad.mit.edu	37	10	68687370	68687370	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:68687370G>A	uc001jmz.1	+	2	1246	c.696G>A	c.(694-696)CAG>CAA	p.Q232Q	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_Silent_p.Q232Q	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	232	Extracellular (Potential).|LRR 8.					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						TCAGCCTTCAGAACCTTTACT	0.453		NaN											0	0	0	0.003271	0	31	69									
KIAA1274	27143	broad.mit.edu	37	10	72324122	72324122	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:72324122G>A	uc001jrd.3	+	19	2546	c.2265G>A	c.(2263-2265)GCG>GCA	p.A755A	KIAA1274_uc001jre.3_Silent_p.A46A	NM_014431	NP_055246	Q9ULE6	PALD_HUMAN	KIAA1274	755										ovary(2)|central_nervous_system(1)	3						TCCTCCAGGCGAAGGCAGCGA	0.617		NaN											0	0	0	0.004878	0	30	56									
SLC29A3	55315	broad.mit.edu	37	10	73111520	73111520	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:73111520G>C	uc001jrr.3	+	4	642	c.585G>C	c.(583-585)ATG>ATC	p.M195I	SLC29A3_uc001jrs.3_Missense_Mutation_p.M195I|SLC29A3_uc010qjq.1_Missense_Mutation_p.M49I|SLC29A3_uc001jrt.3_Intron|SLC29A3_uc001jru.3_Missense_Mutation_p.M7I	NM_018344	NP_060814	Q9BZD2	S29A3_HUMAN	solute carrier family 29 (nucleoside	195	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|late endosome membrane|lysosomal membrane	nucleoside transmembrane transporter activity				0						CCTTTCCTATGAGGAACTCCC	0.577		NaN											0	0	0	0.00245	0	10	17									
CDH23	64072	broad.mit.edu	37	10	73464806	73464806	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:73464806A>G	uc001jrx.3	+	24	3249	c.2872A>G	c.(2872-2874)ATC>GTC	p.I958V	CDH23_uc001jry.2_Missense_Mutation_p.I574V|CDH23_uc001jrz.2_Missense_Mutation_p.I574V	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	958	Cadherin 9.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						CCGCGAGCGCATCGCGGAGTA	0.677		NaN											0	0	0	0.014323	0	18	41									
HPSE2	60495	broad.mit.edu	37	10	100249921	100249921	+	Silent	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:100249921C>G	uc001kpn.1	-	10	1413	c.1353G>C	c.(1351-1353)CTG>CTC	p.L451L	HPSE2_uc009xwc.1_Silent_p.L441L|HPSE2_uc001kpo.1_Silent_p.L383L|HPSE2_uc009xwd.1_Silent_p.L329L	NM_021828	NP_068600	Q8WWQ2	HPSE2_HUMAN	heparanase 2	451					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			ovary(1)	1				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		TGGGGCCGATCAGGCGCTTGT	0.552		NaN											0	0	0	0.01441	0	42	67									
MGEA5	10724	broad.mit.edu	37	10	103567511	103567511	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:103567511C>T	uc001ktv.2	-	5	1071	c.628G>A	c.(628-630)GAA>AAA	p.E210K	MGEA5_uc010qqe.1_Missense_Mutation_p.E210K|MGEA5_uc009xws.2_Missense_Mutation_p.E210K|MGEA5_uc001ktw.2_Missense_Mutation_p.E210K|MGEA5_uc009xwt.2_Missense_Mutation_p.E68K|MGEA5_uc010qqf.1_RNA	NM_012215	NP_036347	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	210					glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		AGGAAAGTTTCTGGCTCTCCT	0.393		NaN											0	0	0	0.012319	0	18	114									
PPRC1	23082	broad.mit.edu	37	10	103906708	103906708	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:103906708G>C	uc001kum.2	+	9	3998	c.3959G>C	c.(3958-3960)CGA>CCA	p.R1320P	PPRC1_uc001kun.2_Missense_Mutation_p.R1200P|PPRC1_uc010qqj.1_Intron|PPRC1_uc009xxa.2_Intron	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	1320					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GTGGGCTCCCGATGGAATGTC	0.607		NaN											0	0	0	0.010729	0	11	42									
PPRC1	23082	broad.mit.edu	37	10	103908426	103908426	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:103908426G>C	uc001kum.2	+	11	4631	c.4592G>C	c.(4591-4593)AGA>ACA	p.R1531T	PPRC1_uc001kun.2_Missense_Mutation_p.R1409T|PPRC1_uc010qqj.1_Missense_Mutation_p.R1267T|PPRC1_uc009xxa.2_RNA	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	1531	Arg-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		CAAAGGCAAAGAGTGCTACAA	0.493		NaN											0	0	0	0.01441	0	41	104									
PPRC1	23082	broad.mit.edu	37	10	103909067	103909067	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:103909067G>C	uc001kum.2	+	13	4911	c.4872G>C	c.(4870-4872)AAG>AAC	p.K1624N	PPRC1_uc001kun.2_Missense_Mutation_p.K1502N|PPRC1_uc010qqj.1_Missense_Mutation_p.K1360N|PPRC1_uc009xxa.2_RNA|NOLC1_uc001kuo.2_5'Flank|NOLC1_uc001kup.2_5'Flank|NOLC1_uc001kuq.2_5'Flank|NOLC1_uc009xxb.1_5'Flank|NOLC1_uc001kur.2_5'Flank	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	1624					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		AGTTCTGCAAGAGGAGCTATT	0.557		NaN											0	0	0	0.008361	0	28	65									
CALHM2	51063	broad.mit.edu	37	10	105207266	105207266	+	Silent	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:105207266G>C	uc001kwz.2	-	3	1001	c.615C>G	c.(613-615)CTC>CTG	p.L205L	CALHM2_uc001kxa.2_Silent_p.L205L|CALHM2_uc001kxc.2_3'UTR|CALHM2_uc001kxb.2_Silent_p.L205L	NM_015916	NP_057000	Q9HA72	CAHM2_HUMAN	calcium homeostasis modulator 2	205	Helical; (Potential).					integral to membrane				skin(1)	1						AGTAATGCTTGAGGCACTTGG	0.617		NaN											0	0	0	0.009096	0	3	38									
COL17A1	1308	broad.mit.edu	37	10	105819447	105819447	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:105819447C>G	uc001kxr.2	-	15	1340	c.1171G>C	c.(1171-1173)GAA>CAA	p.E391Q	COL17A1_uc010qqv.1_Missense_Mutation_p.E375Q	NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	391	Cytoplasmic (Potential).|Nonhelical region (NC16).				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GCTTGCTTTTCTTTTTTTAGG	0.438		NaN											0	0	0	0.014323	0	19	38									
SORCS3	22986	broad.mit.edu	37	10	107007054	107007054	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:107007054G>C	uc001kyi.1	+	22	3297	c.3070G>C	c.(3070-3072)GAT>CAT	p.D1024H	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	1024	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GTGGAGAAAAGATATTGGCAA	0.383		NaN											0	0	0	0.009535	0	24	46									
FOXI2	399823	broad.mit.edu	37	10	129537070	129537070	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:129537070G>A	uc009yas.2	+	2	798	c.798G>A	c.(796-798)CTG>CTA	p.L266L	uc009yar.1_5'Flank	NM_207426	NP_997309	Q6ZQN5	FOXI2_HUMAN	forkhead box I2	266					epidermal cell fate specification|otic placode formation|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0		all_epithelial(44;0.0021)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)				CCGGGGGCCTGGCGGGCGACT	0.701		NaN											0	0	0	0.001168	0	4	3									
INPP5A	3632	broad.mit.edu	37	10	134459392	134459392	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr10:134459392G>A	uc001llp.2	+	3	386	c.138G>A	c.(136-138)CCG>CCA	p.P46P	INPP5A_uc001llo.1_Silent_p.P46P|INPP5A_uc001llq.2_5'UTR	NM_005539	NP_005530	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase A	46					cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			skin(1)	1		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		CACACAAGCCGCACTTCATGG	0.612		NaN											0	0	0	0.007291	0	20	34									
MUC6	4588	broad.mit.edu	37	11	1028937	1028937	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:1028937C>T	uc001lsw.2	-	12	1456	c.1405G>A	c.(1405-1407)GAG>AAG	p.E469K		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	469	VWFD 2.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GTGACCACCTCGTCCTGAGAG	0.627		NaN											0	0	0	0.013114	0	33	49									
HIPK3	10114	broad.mit.edu	37	11	33370177	33370177	+	Nonsense_Mutation	SNP	C	C	T	rs150770633		TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:33370177C>T	uc001mul.1	+	13	2749	c.2479C>T	c.(2479-2481)CAG>TAG	p.Q827*	HIPK3_uc001mum.1_Nonsense_Mutation_p.Q806*|HIPK3_uc009yjv.1_Nonsense_Mutation_p.Q806*	NM_005734	NP_005725	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3 isoform	827	Interaction with FAS (By similarity).|Interaction with AR (By similarity).				anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)|skin(1)|stomach(1)|ovary(1)|pancreas(1)	5						ACAGGACAATCAGAACTCAGA	0.378		NaN											0	0	0	0.00623	0	36	42									
OR5M8	219484	broad.mit.edu	37	11	56258214	56258214	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:56258214G>A	uc001nix.1	-	1	633	c.633C>T	c.(631-633)TTC>TTT	p.F211F		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	211	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					TACATATGATGAAGAGAGAAA	0.433		NaN											0	0	0	0.004482	0	8	69									
GLYATL1	92292	broad.mit.edu	37	11	58711103	58711103	+	Translation_Start_Site	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:58711103G>A	uc001nnf.2	+	3	298	c.-78G>A	c.(-80--76)TTGTG>TTATG		uc001nng.1_Intron|GLYATL1_uc001nnh.1_Missense_Mutation_p.V38M|GLYATL1_uc001nni.1_Translation_Start_Site|GLYATL1_uc001nnj.1_Translation_Start_Site			Q969I3	GLYL1_HUMAN	SubName: Full=Glycine acyltransferase family-C; SubName: Full=Glycine-N-acyltransferase-like 1, isoform CRA_a;							mitochondrion	glycine N-acyltransferase activity			ovary(1)	1					Glycine(DB00145)	ggatccaattgtgtccattga	0		NaN											0	0	0	0.010729	0	9	56									
TCN1	6947	broad.mit.edu	37	11	59623355	59623355	+	Missense_Mutation	SNP	G	G	C	rs146250932	byFrequency	TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:59623355G>C	uc001noj.2	-	6	1022	c.924C>G	c.(922-924)TGC>TGG	p.C308W		NM_001062	NP_001053	P20061	TCO1_HUMAN	transcobalamin I precursor	308					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			ovary(2)	2		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AAGCAGAGACGCAAGAAGAGT	0.443		NaN											0	0	0	0.004656	0	20	66									
EML3	256364	broad.mit.edu	37	11	62378418	62378418	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:62378418G>A	uc001ntu.1	-	4	807	c.499C>T	c.(499-501)CGG>TGG	p.R167W	EML3_uc001ntr.1_Missense_Mutation_p.R139W|EML3_uc001nts.1_Missense_Mutation_p.R139W|EML3_uc001ntt.1_Missense_Mutation_p.R51W|EML3_uc010rly.1_Missense_Mutation_p.R167W|EML3_uc009yny.1_5'UTR|ROM1_uc001ntv.2_5'Flank	NM_153265	NP_694997	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like	167						cytoplasm|microtubule	protein binding			ovary(1)	1						AGCTTCTGCCGAGGCCGCTCT	0.612		NaN											0	0	0	0.003163	0	12	74									
GANAB	23193	broad.mit.edu	37	11	62398090	62398090	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:62398090C>G	uc001nub.2	-	11	1402	c.1369G>C	c.(1369-1371)GCT>CCT	p.A457P	GANAB_uc001nua.2_Missense_Mutation_p.A479P|GANAB_uc001nuc.2_Missense_Mutation_p.A360P|GANAB_uc010rma.1_Missense_Mutation_p.A365P|GANAB_uc010rmb.1_Missense_Mutation_p.A343P	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	457					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						CTCTTAGAAGCCAAGCGCTCA	0.537		NaN											0	0	0	0.009096	0	4	45									
GANAB	23193	broad.mit.edu	37	11	62398117	62398117	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:62398117G>A	uc001nub.2	-	11	1375	c.1342C>T	c.(1342-1344)CAG>TAG	p.Q448*	GANAB_uc001nua.2_Nonsense_Mutation_p.Q470*|GANAB_uc001nuc.2_Nonsense_Mutation_p.Q351*|GANAB_uc010rma.1_Nonsense_Mutation_p.Q356*|GANAB_uc010rmb.1_Nonsense_Mutation_p.Q334*	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	448					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						GTGCGGGGCTGAGGGAAGCGA	0.547		NaN											0	0	0	0.001855	0	11	58									
INTS5	80789	broad.mit.edu	37	11	62416959	62416959	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:62416959G>A	uc001nud.2	-	2	646	c.593C>T	c.(592-594)TCG>TTG	p.S198L	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	198					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						AATGAGAGCCGAGAGGCACTG	0.532		NaN											0	0	0	0.003755	0	31	102									
CDCA5	113130	broad.mit.edu	37	11	64846584	64846584	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:64846584C>G	uc001ocp.2	-	6	919	c.754G>C	c.(754-756)GAA>CAA	p.E252Q		NM_080668	NP_542399	Q96FF9	CDCA5_HUMAN	cell division cycle associated 5	252					cell division|double-strand break repair|G1/S transition of mitotic cell cycle|mitotic chromosome condensation|mitotic metaphase plate congression|mitotic sister chromatid cohesion|regulation of cohesin localization to chromatin	cytoplasm|nuclear chromatin|plasma membrane	chromatin binding|identical protein binding				0						GCATCTCATTCAACCAGGAGA	0.572		NaN											0	0	0	0.010504	0	14	29									
SLC22A20	440044	broad.mit.edu	37	11	64981715	64981715	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:64981715C>G	uc010roc.1	+	1	369	c.366C>G	c.(364-366)ATC>ATG	p.I122M	SLC22A20_uc010rob.1_Missense_Mutation_p.I122M	NM_001004326	NP_001004326	A6NK97	S22AK_HUMAN	solute carrier family 22, member 20	122	Extracellular (Potential).				ion transport	integral to membrane	transmembrane transporter activity			central_nervous_system(1)	1						CGTCCACCATCGTGATGGAGG	0.657		NaN											0	0	0	0.009096	0	4	12									
SF3B2	10992	broad.mit.edu	37	11	65824372	65824372	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:65824372C>T	uc001ogy.1	+	6	653	c.613C>T	c.(613-615)CGG>TGG	p.R205W	SF3B2_uc001ogx.1_Missense_Mutation_p.R204W	NM_006842	NP_006833	Q13435	SF3B2_HUMAN	splicing factor 3B subunit 2	205					interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(2)|breast(1)	3						CCCAGTCCCTCGGCCCCCACA	0.587		NaN											0	0	0	0.012319	0	17	66									
CLCF1	23529	broad.mit.edu	37	11	67134963	67134963	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:67134963C>G	uc001okq.2	-	2	347	c.151G>C	c.(151-153)GAG>CAG	p.E51Q	LOC100130987_uc010rpo.1_Intron|CLCF1_uc010rpp.1_Missense_Mutation_p.E41Q	NM_013246	NP_037378	Q9UBD9	CLCF1_HUMAN	cardiotrophin-like cytokine factor 1 precursor	51					B cell differentiation|cytokine-mediated signaling pathway|JAK-STAT cascade|negative regulation of neuron apoptosis|positive regulation of astrocyte differentiation|positive regulation of B cell proliferation|positive regulation of immunoglobulin production|positive regulation of isotype switching to IgE isotypes|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	ciliary neurotrophic factor receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity				0			BRCA - Breast invasive adenocarcinoma(15;2.39e-06)			AGTTGGTGCTCCAGGTAGCGG	0.602		NaN											0	0	0	0.00874	0	37	97									
SHANK2	22941	broad.mit.edu	37	11	70332669	70332669	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:70332669G>A	uc001oqc.2	-	21	3807	c.3729C>T	c.(3727-3729)CTC>CTT	p.L1243L	SHANK2_uc010rqn.1_Silent_p.L655L|SHANK2_uc001opz.2_Silent_p.L648L|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	864					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			GAGGTTTGTTGAGGTCGGCCT	0.632		NaN											0	0	0	0.008291	0	8	97									
ARAP1	116985	broad.mit.edu	37	11	72437906	72437906	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:72437906G>A	uc001osu.2	-	3	457	c.268C>T	c.(268-270)CGC>TGC	p.R90C	ARAP1_uc001osv.2_Missense_Mutation_p.R90C	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	90					actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						GGTGGTGAGCGGAAGATGTGG	0.726		NaN											0	0	0	0.009096	0	3	14									
C2CD3	26005	broad.mit.edu	37	11	73814626	73814626	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:73814626G>C	uc001ouu.2	-	14	2357	c.2130C>G	c.(2128-2130)ATC>ATG	p.I710M		NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	710						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					ACTTAGTATTGATACCAGTGA	0.373		NaN											0	0	0	0.004656	0	26	47									
SERPINH1	871	broad.mit.edu	37	11	75282943	75282943	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:75282943G>C	uc001owr.2	+	5	1301	c.1072G>C	c.(1072-1074)GAG>CAG	p.E358Q	SERPINH1_uc009yug.2_Missense_Mutation_p.E358Q|SERPINH1_uc001ows.2_Missense_Mutation_p.E358Q|SERPINH1_uc001owt.2_Missense_Mutation_p.E141Q	NM_001235	NP_001226	P50454	SERPH_HUMAN	serine (or cysteine) proteinase inhibitor, clade	358					regulation of proteolysis|response to unfolded protein	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	collagen binding|serine-type endopeptidase inhibitor activity			ovary(2)	2	Ovarian(111;0.11)					CACCGCCTTTGAGTTGGACAC	0.597		NaN											0	0	0	0.014323	0	17	27									
GDPD4	220032	broad.mit.edu	37	11	76980082	76980082	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:76980082G>A	uc001oyf.2	-	8	762	c.511C>T	c.(511-513)CTT>TTT	p.L171F		NM_182833	NP_878253	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain	171	Helical; (Potential).				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			skin(1)	1						AAAAGGATAAGAAGAAAGGGT	0.438		NaN											0	0	0	0.00308	0	7	38									
NARS2	79731	broad.mit.edu	37	11	78239958	78239958	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:78239958C>T	uc001ozi.2	-	6	995	c.619G>A	c.(619-621)GAG>AAG	p.E207K	NARS2_uc010rsq.1_5'UTR	NM_024678	NP_078954	Q96I59	SYNM_HUMAN	asparaginyl-tRNA synthetase 2, mitochondrial	207					asparaginyl-tRNA aminoacylation	mitochondrial matrix	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding			ovary(2)	2	all_cancers(14;2.63e-17)|all_epithelial(13;1.85e-19)				L-Asparagine(DB00174)	AAATTCTCCTCAGGTACCTTA	0.353		NaN											0	0	0	0.006999	0	35	75									
EED	8726	broad.mit.edu	37	11	85961447	85961447	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:85961447C>G	uc001pbp.2	+	2	681	c.224C>G	c.(223-225)TCA>TGA	p.S75*	EED_uc010rtm.1_Nonsense_Mutation_p.S75*|EED_uc001pbq.2_Nonsense_Mutation_p.S75*|EED_uc001pbr.2_Nonsense_Mutation_p.S75*|EED_uc001pbs.2_Nonsense_Mutation_p.S75*	NM_003797	NP_003788	O75530	EED_HUMAN	embryonic ectoderm development isoform a	75					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			skin(1)|pancreas(1)	2		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				AAATGGAAGTCAAAGAAATGC	0.388		NaN											0	0	0	0.013726	0	31	72									
NAALAD2	10003	broad.mit.edu	37	11	89896561	89896561	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:89896561G>A	uc001pdf.3	+	10	1268	c.1159G>A	c.(1159-1161)GAA>AAA	p.E387K	NAALAD2_uc009yvx.2_Missense_Mutation_p.E354K|NAALAD2_uc009yvy.2_Intron|NAALAD2_uc001pde.2_Missense_Mutation_p.E294K	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	387	Extracellular (Potential).|NAALADase.				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				TGTTTTGCAAGAAATTGCCCG	0.398		NaN											0	0	0	0.01441	0	52	101									
PIWIL4	143689	broad.mit.edu	37	11	94316613	94316613	+	Splice_Site	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:94316613G>A	uc001pfa.2	+	5	725	c.514_splice	c.e5-1	p.V172_splice	PIWIL4_uc010rue.1_Splice_Site|PIWIL4_uc009ywk.1_Splice_Site	NM_152431	NP_689644	Q7Z3Z4	PIWL4_HUMAN	piwi-like 4						cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			skin(1)	1		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CTTTTTCCCAGGTCACAGAGT	0.418		NaN											0	0	0	0.01441	0	71	165									
CASP5	838	broad.mit.edu	37	11	104871143	104871143	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:104871143G>A	uc010rva.1	-	6	829	c.797C>T	c.(796-798)TCT>TTT	p.S266F	CASP5_uc010ruz.1_Missense_Mutation_p.S279F|CASP5_uc010rvb.1_Missense_Mutation_p.S208F|CASP5_uc010rvc.1_Missense_Mutation_p.S124F|CASP5_uc009yxh.2_Missense_Mutation_p.S48F|CASP5_uc010rvd.1_Missense_Mutation_p.S48F	NM_004347	NP_004338	P51878	CASP5_HUMAN	caspase 5 isoform a precursor	266					apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			ovary(2)|lung(1)	3		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		GATGCCATGAGACATGAGTAC	0.463		NaN											0	0	0	0.005443	0	23	70									
SLC35F2	54733	broad.mit.edu	37	11	107673745	107673745	+	Silent	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:107673745G>C	uc001pjq.2	-	7	1342	c.921C>G	c.(919-921)CTC>CTG	p.L307L	SLC35F2_uc010rvu.1_Silent_p.L159L	NM_017515	NP_059985	Q8IXU6	S35F2_HUMAN	solute carrier family 35, member F2	307	Helical; (Potential).				transport	integral to membrane				central_nervous_system(1)	1		all_cancers(61;9.46e-06)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;0.000111)|all_hematologic(158;0.000315)|all_epithelial(67;0.00197)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)|Epithelial(105;0.000105)|all cancers(92;0.00217)		CAAACAGAAAGAGTCCAACAA	0.428		NaN											0	0	0	0.010504	0	18	42									
NPAT	4863	broad.mit.edu	37	11	108044182	108044182	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:108044182G>C	uc001pjz.3	-	13	1631	c.1529C>G	c.(1528-1530)ACT>AGT	p.T510S	NPAT_uc001pka.2_Missense_Mutation_p.T305S	NM_002519	NP_002510	Q14207	NPAT_HUMAN	nuclear protein,  ataxia-telangiectasia locus	510					positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			ovary(2)	2		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		AACAAATGAAGTTATTGGTAT	0.363		NaN											0	0	0	0.01441	0	43	91									
SIK2	23235	broad.mit.edu	37	11	111594445	111594445	+	Silent	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:111594445C>G	uc001plt.2	+	15	2491	c.2373C>G	c.(2371-2373)CTC>CTG	p.L791L		NM_015191	NP_056006	Q9H0K1	SIK2_HUMAN	SNF1-like kinase 2	791					intracellular protein kinase cascade|regulation of insulin receptor signaling pathway	Golgi apparatus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|skin(1)	3						GCCCTTTCCTCAGCCAGTACC	0.632		NaN											0	0	0	0.01441	0	136	297									
DSCAML1	57453	broad.mit.edu	37	11	117302289	117302289	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:117302289C>G	uc001prh.1	-	31	5517	c.5515G>C	c.(5515-5517)GAG>CAG	p.E1839Q		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1779	Cytoplasmic (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CTGTCACTCTCAGTGACCGTG	0.632		NaN											0	0	0	0.014323	0	21	59									
MPZL2	10205	broad.mit.edu	37	11	118128003	118128003	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:118128003C>G	uc001psn.2	-	5	751	c.610G>C	c.(610-612)GAG>CAG	p.E204Q	MPZL2_uc001pso.2_Missense_Mutation_p.E204Q	NM_005797	NP_005788	O60487	MPZL2_HUMAN	myelin protein zero-like 2 precursor	204	Cytoplasmic (Potential).				anatomical structure morphogenesis|homophilic cell adhesion	cytoskeleton|integral to membrane				skin(1)	1	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		ACCTTTTTCTCTTGGTTGAGC	0.388		NaN											0	0	0	0.001855	0	12	84									
CBL	867	broad.mit.edu	37	11	119167741	119167741	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:119167741C>T	uc001pwe.2	+	13	2288	c.2150C>T	c.(2149-2151)TCA>TTA	p.S717L		NM_005188	NP_005179	P22681	CBL_HUMAN	Cas-Br-M (murine) ecotropic retroviral	717	Interaction with CD2AP.|Asp/Glu-rich (acidic).				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(135)|lung(10)|central_nervous_system(2)|ovary(1)|breast(1)	149		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		TCCCAGAGTTCACGGTAGGTT	0.507		NaN							CBL_gene-associated_Juvenile_Myelomonocytic_Leukemia_and_Developmental_Anomalies|Noonan_syndrome				0	0	0	0.01441	0	40	71									
NFRKB	4798	broad.mit.edu	37	11	129762708	129762708	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr11:129762708C>G	uc001qfi.2	-	3	238	c.37G>C	c.(37-39)GAA>CAA	p.E13Q	NFRKB_uc001qfg.2_Missense_Mutation_p.E26Q|NFRKB_uc001qfh.2_Missense_Mutation_p.E36Q|NFRKB_uc010sbw.1_Missense_Mutation_p.E13Q	NM_001143835	NP_001137307	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	13					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			ovary(3)	3	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		GGACCAAGTTCCAGAGGATCT	0.517		NaN											0	0	0	0.012213	0	29	136									
B4GALNT3	283358	broad.mit.edu	37	12	660168	660168	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:660168C>T	uc001qii.1	+	11	1078	c.1078C>T	c.(1078-1080)CCT>TCT	p.P360S	B4GALNT3_uc001qij.1_Missense_Mutation_p.P262S|B4GALNT3_uc001qik.1_5'Flank	NM_173593	NP_775864	Q6L9W6	B4GN3_HUMAN	beta	360	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			ovary(1)|skin(1)	2	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			GGATGGGCTTCCTCTGCAGCG	0.607		NaN											0	0	0	0.005524	0	31	69									
DCP1B	196513	broad.mit.edu	37	12	2061674	2061674	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:2061674G>A	uc001qjx.1	-	7	1512	c.1432C>T	c.(1432-1434)CCT>TCT	p.P478S	DCP1B_uc010sdy.1_Missense_Mutation_p.P376S	NM_152640	NP_689853	Q8IZD4	DCP1B_HUMAN	decapping enzyme Dcp1b	478					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			GCGAGCACAGGAAACTTAGCG	0.512		NaN											0	0	0	0.00499	0	17	35									
LRP6	4040	broad.mit.edu	37	12	12318175	12318175	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:12318175G>T	uc001rah.3	-	8	1742	c.1600C>A	c.(1600-1602)CAC>AAC	p.H534N	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Missense_Mutation_p.H534N	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	534	Beta-propeller 2.|Extracellular (Potential).|LDL-receptor class B 9.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				CCAAATATGTGAGGAATTTTG	0.398		NaN											1	0	4.97629e-18	0.01441	5.61156e-18	58	126									
PIK3C2G	5288	broad.mit.edu	37	12	18650568	18650568	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:18650568C>T	uc001rdt.2	+	21	2895	c.2779C>T	c.(2779-2781)CGT>TGT	p.R927C	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.R968C|PIK3C2G_uc010sic.1_Missense_Mutation_p.R746C	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	927	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				AGATGATCTTCGTCAGGATAT	0.363		NaN											0	0	0	0.013537	0	8	41									
SLCO1B1	10599	broad.mit.edu	37	12	21392046	21392046	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:21392046G>A	uc001req.3	+	15	2103	c.1999G>A	c.(1999-2001)GAA>AAA	p.E667K		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	667	Cytoplasmic (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	TGTCATGGATGAAGCAAACTT	0.318		NaN											0	0	0	0.00308	0	8	28									
ABCC9	10060	broad.mit.edu	37	12	21958120	21958120	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:21958120C>T	uc001rfi.1	-	38	4658	c.4638G>A	c.(4636-4638)ATG>ATA	p.M1546I	ABCC9_uc001rfh.2_Intron|ABCC9_uc001rfj.1_Missense_Mutation_p.M1510I|ABCC9_uc001rfg.2_Intron	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1546	Cytoplasmic (Potential).|ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity	p.R1546H(1)		ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	ACTTGTTGGTCATCACCAAAG	0.438		NaN											0	0	0	0.010504	0	16	62									
IRAK4	51135	broad.mit.edu	37	12	44176171	44176171	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:44176171G>C	uc001rnu.3	+	10	1133	c.1003G>C	c.(1003-1005)GCT>CCT	p.A335P	IRAK4_uc001rnt.3_Missense_Mutation_p.A335P|IRAK4_uc001rnx.3_Missense_Mutation_p.A211P|IRAK4_uc001rny.3_Missense_Mutation_p.A211P|IRAK4_uc010sky.1_Missense_Mutation_p.A211P|IRAK4_uc001rnv.3_Missense_Mutation_p.A211P|IRAK4_uc001rnw.3_Missense_Mutation_p.A211P	NM_001114182	NP_001107654	Q9NWZ3	IRAK4_HUMAN	interleukin-1 receptor-associated kinase 4	335	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity				0	all_cancers(12;0.00149)	Lung NSC(34;0.0804)|all_lung(34;0.181)		GBM - Glioblastoma multiforme(48;0.04)		CCTTGCACGGGCTTCTGAGAA	0.388		NaN											0	0	0	0.008871	0	16	41									
COL2A1	1280	broad.mit.edu	37	12	48375126	48375126	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:48375126C>T	uc001rqu.2	-	37	2644	c.2463G>A	c.(2461-2463)CCG>CCA	p.P821P	COL2A1_uc009zkw.2_RNA|COL2A1_uc001rqv.2_Silent_p.P752P	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	821	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	AGACACTCACCGGAGCGCCAC	0.662		NaN											0	0	0	0.010729	0	8	16									
MLL2	8085	broad.mit.edu	37	12	49448457	49448457	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:49448457A>G	uc001rta.3	-	3	254	c.254T>C	c.(253-255)TTT>TCT	p.F85S		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	85					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGGCAACTCAAAGCGCCGTAG	0.622		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.004672	0	3	10									
KRT80	144501	broad.mit.edu	37	12	52574306	52574306	+	Silent	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:52574306G>T	uc001rzx.2	-	4	755	c.657C>A	c.(655-657)ATC>ATA	p.I219I	KRT80_uc001rzw.2_Silent_p.I254I|KRT80_uc001rzy.2_Silent_p.I219I	NM_182507	NP_872313	Q6KB66	K2C80_HUMAN	keratin 80 isoform a	219	Coil 1B.|Rod.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.108)		CCTGCTCATAGATGGTTTTCA	0.552		NaN											1	0	4.67007e-22	0.00874	5.38073e-22	36	158									
KRT76	51350	broad.mit.edu	37	12	53165706	53165706	+	Silent	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:53165706G>C	uc001sax.2	-	6	1266	c.1212C>G	c.(1210-1212)CTC>CTG	p.L404L		NM_015848	NP_056932	Q01546	K22O_HUMAN	keratin 76	404	Rod.|Coil 2.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|skin(1)	2						TCATCCTGTTGAGCTCCATGA	0.547		NaN											0	0	0	0.01441	0	44	91									
PTPRB	5787	broad.mit.edu	37	12	70956762	70956762	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:70956762G>C	uc001swb.3	-	14	3406	c.3376C>G	c.(3376-3378)CTC>GTC	p.L1126V	PTPRB_uc010sto.1_Missense_Mutation_p.L1036V|PTPRB_uc010stp.1_Missense_Mutation_p.L1036V|PTPRB_uc001swc.3_Missense_Mutation_p.L1344V|PTPRB_uc001swa.3_Missense_Mutation_p.L1256V|PTPRB_uc001swd.3_Missense_Mutation_p.L1343V|PTPRB_uc009zrr.1_Missense_Mutation_p.L1223V	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1126	Fibronectin type-III 13.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CTCTCCTGGAGATTCCCATCT	0.512		NaN											0	0	0	0.004482	0	8	60									
TBC1D15	64786	broad.mit.edu	37	12	72312286	72312286	+	Silent	SNP	C	C	T	rs141790587	byFrequency	TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:72312286C>T	uc001swu.2	+	15	1683	c.1674C>T	c.(1672-1674)TTC>TTT	p.F558F	TBC1D15_uc010stt.1_Silent_p.F527F|TBC1D15_uc001swv.2_Silent_p.F541F|TBC1D15_uc001sww.2_Silent_p.F290F	NM_022771	NP_073608	Q8TC07	TBC15_HUMAN	TBC1 domain family, member 15 isoform 1	536	Rab-GAP TBC.						protein binding|Rab GTPase activator activity				0						TAATCAGATTCAAAAGGGAAT	0.294		NaN											0	0	0	0.003271	0	27	92									
NAV3	89795	broad.mit.edu	37	12	78400995	78400995	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:78400995G>A	uc001syp.2	+	8	1850	c.1677G>A	c.(1675-1677)GGG>GGA	p.G559G	NAV3_uc001syo.2_Silent_p.G559G	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	559						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CTACCAAGGGGAGCCCTTCCC	0.483		NaN								HNSCC(70;0.22)			0	0	0	0.014323	0	19	46									
LRRIQ1	84125	broad.mit.edu	37	12	85450069	85450069	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:85450069G>A	uc001tac.2	+	8	1609	c.1498G>A	c.(1498-1500)GAA>AAA	p.E500K	LRRIQ1_uc001tab.1_Missense_Mutation_p.E500K|LRRIQ1_uc001taa.1_Missense_Mutation_p.E475K	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	500										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		GGTCAAGCAAGAAAGAAAATA	0.303		NaN											0	0	0	0.001855	0	10	37									
UTP20	27340	broad.mit.edu	37	12	101682793	101682793	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:101682793G>C	uc001tia.1	+	6	727	c.571G>C	c.(571-573)GAA>CAA	p.E191Q	UTP20_uc009ztz.1_Missense_Mutation_p.E191Q	NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	191	HEAT 1.				endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						TTTTGCTGCTGAAAGTTTTAC	0.254		NaN											0	0	0	0.006214	0	8	29									
UTP20	27340	broad.mit.edu	37	12	101767377	101767377	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:101767377G>C	uc001tia.1	+	54	7119	c.6963G>C	c.(6961-6963)GAG>GAC	p.E2321D		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	2321					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						TGCTCCATGAGAACTGCGGAA	0.478		NaN											0	0	0	0.007413	0	15	25									
NT5DC3	51559	broad.mit.edu	37	12	104187715	104187715	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:104187715C>G	uc010swe.1	-	7	855	c.814G>C	c.(814-816)GAA>CAA	p.E272Q		NM_001031701	NP_001026871	Q86UY8	NT5D3_HUMAN	5'-nucleotidase domain containing 3	272							hydrolase activity|metal ion binding			ovary(2)|skin(1)	3						GAGCACATACCAATGTCTGCT	0.413		NaN											0	0	0	0.008361	0	21	80									
BRAP	8315	broad.mit.edu	37	12	112123571	112123571	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:112123571C>G	uc001tsn.3	-	1	220	c.26G>C	c.(25-27)CGA>CCA	p.R9P	BRAP_uc009zvv.2_5'Flank|ACAD10_uc009zvw.2_5'Flank|ACAD10_uc001tso.3_5'Flank|ACAD10_uc001tsp.2_5'Flank|ACAD10_uc009zvx.2_5'Flank|ACAD10_uc001tsq.2_5'Flank	NM_006768	NP_006759	Q7Z569	BRAP_HUMAN	BRCA1 associated protein	9					MAPKKK cascade|negative regulation of signal transduction|Ras protein signal transduction	cytoplasm|ubiquitin ligase complex	identical protein binding|nuclear localization sequence binding|nucleotide binding|ubiquitin-protein ligase activity|zinc ion binding			lung(1)	1						GAGCTCCAATCGGATAACAAC	0.612		NaN											0	0	0	0.008291	0	9	12									
RNF10	9921	broad.mit.edu	37	12	121001720	121001720	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:121001720G>C	uc001typ.3	+	10	2122	c.1639G>C	c.(1639-1641)GAG>CAG	p.E547Q	RNF10_uc010szk.1_RNA|RNF10_uc001tyq.3_Missense_Mutation_p.E458Q	NM_014868	NP_055683	Q8N5U6	RNF10_HUMAN	ring finger protein 10	547					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AACTGTGGTGGAGATTGCTGG	0.552		NaN											0	0	0	0.004656	0	19	153									
KNTC1	9735	broad.mit.edu	37	12	123095437	123095437	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:123095437C>T	uc001ucv.2	+	53	5775	c.5612C>T	c.(5611-5613)TCA>TTA	p.S1871L	KNTC1_uc010taf.1_Missense_Mutation_p.S796L	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	1871					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		TTTGCAACATCAACTACAACC	0.333		NaN											0	0	0	0.003163	0	12	47									
ULK1	8408	broad.mit.edu	37	12	132404537	132404537	+	Silent	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr12:132404537G>C	uc001uje.2	+	26	3085	c.2817G>C	c.(2815-2817)CTG>CTC	p.L939L		NM_003565	NP_003556	O75385	ULK1_HUMAN	Unc-51-like kinase 1	939					autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		TGCGCAGGCTGAATGAGCTGT	0.647		NaN											0	0	0	0.010729	0	9	48									
MPHOSPH8	54737	broad.mit.edu	37	13	20242605	20242605	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:20242605C>G	uc001umh.2	+	11	2272	c.2263C>G	c.(2263-2265)CGA>GGA	p.R755G	MPHOSPH8_uc001umg.2_Missense_Mutation_p.R755G	NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	755					cell cycle	cytoplasm|nucleus					0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		CGCATGTCATCGACTCTGTGA	0.413		NaN											0	0	0	0.006214	0	10	32									
XPO4	64328	broad.mit.edu	37	13	21442798	21442798	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:21442798C>G	uc001unq.3	-	2	148	c.112G>C	c.(112-114)GAG>CAG	p.E38Q	XPO4_uc010tcr.1_Intron	NM_022459	NP_071904	Q9C0E2	XPO4_HUMAN	exportin 4	38					protein transport	cytoplasm|nucleus	protein binding			large_intestine(1)|ovary(1)|kidney(1)	3		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		AATATGTGCTCTGCATGCTGG	0.323		NaN											0	0	0	0.01441	0	54	121									
ATP12A	479	broad.mit.edu	37	13	25280593	25280593	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:25280593C>A	uc001upp.2	+	15	2348	c.2161C>A	c.(2161-2163)CAG>AAG	p.Q721K	ATP12A_uc010aaa.2_Missense_Mutation_p.Q727K	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	721	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	GGAGGGCTGTCAGAGGCAGGT	0.567		NaN											1	0	7.87624e-14	0.00278	8.5829e-14	18	29									
USPL1	10208	broad.mit.edu	37	13	31205593	31205593	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:31205593C>T	uc001utc.2	+	4	1282	c.850C>T	c.(850-852)CAA>TAA	p.Q284*	USPL1_uc001utb.2_Nonsense_Mutation_p.Q103*|USPL1_uc001utd.2_Intron|USPL1_uc001ute.1_5'Flank	NM_005800	NP_005791	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	284					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			pancreas(2)|skin(1)	3		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		ATATACCAGTCAATTGAGTGG	0.249		NaN											0	0	0	0.00333	0	20	62									
FRY	10129	broad.mit.edu	37	13	32808828	32808828	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:32808828C>A	uc001utx.2	+	42	6141	c.5645C>A	c.(5644-5646)TCA>TAA	p.S1882*	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1882					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CAACCTCTGTCAGCACATGCC	0.512		NaN											1	0	4.35082e-09	0.010504	4.63716e-09	17	41									
STOML3	161003	broad.mit.edu	37	13	39540963	39540963	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:39540963C>T	uc001uwx.2	-	7	1013	c.875G>A	c.(874-876)TGA>TAA	p.*292*	STOML3_uc010tez.1_Silent_p.*283*	NM_145286	NP_660329	Q8TAV4	STML3_HUMAN	stomatin-like 3 isoform 1	292						integral to membrane|plasma membrane				ovary(1)	1		Lung NSC(96;1.42e-05)|Prostate(109;0.00851)|Breast(139;0.0199)|Lung SC(185;0.0743)		all cancers(112;2.93e-08)|Epithelial(112;3.64e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00107)|BRCA - Breast invasive adenocarcinoma(63;0.00349)|GBM - Glioblastoma multiforme(144;0.0137)		AAGAGGACCTCAGGCTTTATT	0.443		NaN											0	0	0	0.005524	0	29	59									
PCDH8	5100	broad.mit.edu	37	13	53419572	53419572	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:53419572G>C	uc001vhi.2	-	2	3030	c.2827C>G	c.(2827-2829)CAC>GAC	p.H943D	PCDH8_uc001vhj.2_Missense_Mutation_p.H846D	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	943	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CTCTGCATGTGGTTGATGAGA	0.532		NaN											0	0	0	0.013726	0	29	39									
DACH1	1602	broad.mit.edu	37	13	72053449	72053449	+	Splice_Site	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:72053449C>T	uc010thn.1	-	9	2146	c.1723_splice	c.e9-1	p.G575_splice	DACH1_uc010tho.1_Splice_Site_p.G427_splice|DACH1_uc010thp.1_Splice_Site_p.G373_splice	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a						multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		TCAACAGCCCCTGTACAAAGA	0.358		NaN											0	0	0	0.003755	0	26	109									
RNF219	79596	broad.mit.edu	37	13	79190193	79190193	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:79190193G>C	uc001vkw.1	-	6	1762	c.1703C>G	c.(1702-1704)TCA>TGA	p.S568*	uc001vku.1_RNA|RNF219_uc010afb.1_Nonsense_Mutation_p.S378*|RNF219_uc010afc.2_Intron	NM_024546	NP_078822	Q5W0B1	RN219_HUMAN	ring finger protein 219	568	Ser-rich.						zinc ion binding			large_intestine(2)	2		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.0414)		AGATGACTTTGATAACCCATC	0.383		NaN											0	0	0	0.01441	0	63	133									
CLYBL	171425	broad.mit.edu	37	13	100523272	100523272	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr13:100523272G>A	uc001vok.2	+	7	897	c.883G>A	c.(883-885)GAA>AAA	p.E295K	CLYBL_uc010tiy.1_Missense_Mutation_p.E261K	NM_206808	NP_996531	Q8N0X4	CLYBL_HUMAN	citrate lyase beta like precursor	295					cellular aromatic compound metabolic process	citrate lyase complex|mitochondrion	citrate (pro-3S)-lyase activity|metal ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TAAGTGGGCTGAAGAACTGAT	0.393		NaN											0	0	0	0.00333	0	22	69									
SALL2	6297	broad.mit.edu	37	14	21991095	21991095	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:21991095G>A	uc001wbe.2	-	2	3049	c.2767C>T	c.(2767-2769)CAG>TAG	p.Q923*	SALL2_uc010tly.1_Nonsense_Mutation_p.Q921*|SALL2_uc010tlz.1_Nonsense_Mutation_p.Q786*|SALL2_uc001wbf.3_Intron|SALL2_uc010tma.1_Nonsense_Mutation_p.Q788*|SALL2_uc001wbg.1_Intron	NM_005407	NP_005398	Q9Y467	SALL2_HUMAN	sal-like 2	923	C2H2-type 6.						DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|large_intestine(1)	3	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		AGAGCTGCCTGGGAGGGAAAG	0.597		NaN											0	0	0	0.00632	0	27	68									
LRP10	26020	broad.mit.edu	37	14	23342569	23342569	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:23342569G>C	uc001whd.2	+	3	682	c.129G>C	c.(127-129)CAG>CAC	p.Q43H	LRP10_uc001whe.2_5'Flank	NM_014045	NP_054764	Q7Z4F1	LRP10_HUMAN	low density lipoprotein receptor-related protein	43	CUB 1.|Extracellular (Potential).				endocytosis	coated pit|integral to membrane				central_nervous_system(1)	1	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		GCACCTTACAGAGGCCCCTGG	0.602		NaN											0	0	0	0.005443	0	26	53									
ACIN1	22985	broad.mit.edu	37	14	23530572	23530572	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:23530572G>C	uc001wit.3	-	17	3861	c.3533C>G	c.(3532-3534)TCA>TGA	p.S1178*	ACIN1_uc001wio.3_RNA|ACIN1_uc001wip.3_Nonsense_Mutation_p.S420*|ACIN1_uc001wiq.3_Nonsense_Mutation_p.S420*|ACIN1_uc001wir.3_Nonsense_Mutation_p.S451*|ACIN1_uc001wis.3_Nonsense_Mutation_p.S859*|ACIN1_uc010akg.2_Nonsense_Mutation_p.S1165*	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	1178	Arg/Asp/Glu/Lys-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		ACGGGACCTTGATCGGGAACG	0.567		NaN											0	0	0	0.00623	0	33	105									
MYH6	4624	broad.mit.edu	37	14	23858626	23858626	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:23858626T>G	uc001wjv.2	-	28	4021	c.3954A>C	c.(3952-3954)AAA>AAC	p.K1318N	uc010tnn.1_5'Flank|MIR208A_hsa-mir-208a|MI0000251_5'Flank	NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	1318	Potential.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CCAGCTGCCTTTTGAGGTCCT	0.607		NaN											0	0	0	0.006122	0	16	124									
MYH7	4625	broad.mit.edu	37	14	23891402	23891402	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:23891402C>G	uc001wjx.2	-	25	3338	c.3232G>C	c.(3232-3234)GAG>CAG	p.E1078Q		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1078	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TTCAGCCGCTCATCCAGCTGC	0.592		NaN											0	0	0	0.003271	0	27	89									
RABGGTA	5875	broad.mit.edu	37	14	24738898	24738898	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:24738898G>A	uc001wof.2	-	5	852	c.430C>T	c.(430-432)CAC>TAC	p.H144Y	RABGGTA_uc001woe.2_RNA|RABGGTA_uc001wog.2_Missense_Mutation_p.H144Y|RABGGTA_uc001woh.2_RNA|RABGGTA_uc001woi.2_RNA	NM_004581	NP_004572	Q92696	PGTA_HUMAN	Rab geranylgeranyltransferase alpha	144	PFTA 3.				visual perception		Rab geranylgeranyltransferase activity|zinc ion binding				0				GBM - Glioblastoma multiforme(265;0.0184)		TCCCAGCAGTGAACTGGAGGG	0.587		NaN											0	0	0	0.013537	0	11	13									
CDKL1	8814	broad.mit.edu	37	14	50825768	50825768	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:50825768C>T	uc010anu.1	-	14	2083	c.2083G>A	c.(2083-2085)GAG>AAG	p.E695K	CDKL1_uc001wxz.2_Missense_Mutation_p.E91K	NM_004196	NP_004187	Q00532	CDKL1_HUMAN	cyclin-dependent kinase-like 1	90	Protein kinase.					cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(1)|stomach(1)	2	all_epithelial(31;0.000746)|Breast(41;0.0102)					CTGTCCAACTCATGGAGAACT	0.453		NaN											0	0	0	0.01441	0	50	145									
TXNDC16	57544	broad.mit.edu	37	14	52905928	52905928	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:52905928G>C	uc001wzs.2	-	20	2637	c.2188C>G	c.(2188-2190)CAT>GAT	p.H730D	TXNDC16_uc010tqu.1_Missense_Mutation_p.H725D|TXNDC16_uc010aoe.2_RNA	NM_020784	NP_065835	Q9P2K2	TXD16_HUMAN	thioredoxin domain containing 16 isoform 1	730					cell redox homeostasis	extracellular region					0	Breast(41;0.0716)					TTACTGATATGATTTTCTAGT	0.333		NaN											0	0	0	0.008291	0	9	41									
GMFB	2764	broad.mit.edu	37	14	54950455	54950455	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:54950455C>A	uc010tqz.1	-	2	133	c.34G>T	c.(34-36)GAA>TAA	p.E12*	GMFB_uc001xaw.1_RNA	NM_004124	NP_004115	P60983	GMFB_HUMAN	glia maturation factor, beta	12	ADF-H.				nervous system development|protein phosphorylation	intracellular	actin binding|enzyme activator activity|growth factor activity|protein kinase inhibitor activity|signal transducer activity				0						ACTAAATCTTCGGCAACATCA	0.338		NaN											1	0	3.32936e-07	0.006122	3.50364e-07	11	29									
ARID4A	5926	broad.mit.edu	37	14	58831818	58831818	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:58831818C>G	uc001xdp.2	+	20	3265	c.3011C>G	c.(3010-3012)TCA>TGA	p.S1004*	ARID4A_uc001xdo.2_Nonsense_Mutation_p.S1004*|ARID4A_uc001xdq.2_Nonsense_Mutation_p.S1004*|ARID4A_uc010apg.1_Nonsense_Mutation_p.S682*	NM_002892	NP_002883	P29374	ARI4A_HUMAN	retinoblastoma-binding protein 1 isoform I	1004					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|lung(1)	6						CATAACTTTTCAGTAGCTTCA	0.403		NaN											0	0	0	0.010504	0	19	170									
KIAA0586	9786	broad.mit.edu	37	14	58895165	58895165	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:58895165G>C	uc001xdv.3	+	1	456	c.183G>C	c.(181-183)TTG>TTC	p.L61F	KIAA0586_uc010trr.1_Missense_Mutation_p.L61F|KIAA0586_uc001xdt.3_Intron|KIAA0586_uc001xdu.3_Missense_Mutation_p.L46F|KIAA0586_uc010trs.1_Intron|TIMM9_uc010aph.2_5'Flank|TIMM9_uc001xds.2_5'Flank|TIMM9_uc010api.2_5'Flank	NM_014749	NP_055564	E9PGW8	E9PGW8_HUMAN	talpid3 protein	61										ovary(1)	1						GGACTAGTTTGAATGGAACAT	0.383		NaN											0	0	0	0.004656	0	20	55									
PPP2R5E	5529	broad.mit.edu	37	14	63851225	63851225	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:63851225G>C	uc001xgd.1	-	12	1729	c.1139C>G	c.(1138-1140)TCT>TGT	p.S380C	PPP2R5E_uc010tsf.1_Missense_Mutation_p.S304C|PPP2R5E_uc010tsg.1_Missense_Mutation_p.S304C|PPP2R5E_uc001xge.2_Missense_Mutation_p.S380C|PPP2R5E_uc010tsh.1_Missense_Mutation_p.S380C|PPP2R5E_uc001xgf.1_RNA	NM_006246	NP_006237	Q16537	2A5E_HUMAN	epsilon isoform of regulatory subunit B56,	380					signal transduction	cytoplasm|intracellular membrane-bounded organelle|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.00197)|all cancers(60;0.0153)|BRCA - Breast invasive adenocarcinoma(234;0.128)		GATGACGTTAGAGTTTTCTTC	0.363		NaN											0	0	0	0.01441	0	47	123									
SYNE2	23224	broad.mit.edu	37	14	64518876	64518876	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:64518876G>A	uc001xgm.2	+	48	8475	c.8245G>A	c.(8245-8247)GAA>AAA	p.E2749K	SYNE2_uc001xgl.2_Missense_Mutation_p.E2749K	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2749	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TTTGTTGGGTGAACTTAATCC	0.413		NaN											0	0	0	0.01441	0	61	199									
TTC8	123016	broad.mit.edu	37	14	89336504	89336504	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:89336504C>G	uc010ath.2	+	11	1193	c.1059C>G	c.(1057-1059)TTC>TTG	p.F353L	TTC8_uc001xxl.2_Missense_Mutation_p.F98L|TTC8_uc010ati.2_Missense_Mutation_p.F139L|TTC8_uc001xxm.2_Missense_Mutation_p.F297L|TTC8_uc010atj.2_Missense_Mutation_p.F72L|TTC8_uc001xxi.2_Missense_Mutation_p.F337L|TTC8_uc001xxj.2_Missense_Mutation_p.F327L|TTC8_uc001xxk.2_Missense_Mutation_p.F297L	NM_198309	NP_938051	Q8TAM2	TTC8_HUMAN	tetratricopeptide repeat domain 8 isoform B	363	TPR 5.				cilium assembly|establishment of anatomical structure orientation|sensory processing	BBSome|centrosome|cilium membrane|microtubule basal body	protein binding				0						GCAACCACTTCTATTCTGATC	0.363		NaN							Bardet-Biedl_syndrome				0	0	0	0.01441	0	94	131									
TDP1	55775	broad.mit.edu	37	14	90429788	90429788	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:90429788C>G	uc001xxy.2	+	3	629	c.330C>G	c.(328-330)ATC>ATG	p.I110M	TDP1_uc010atm.2_RNA|TDP1_uc001xxz.2_Missense_Mutation_p.I110M|TDP1_uc010atn.2_Missense_Mutation_p.I110M|TDP1_uc001xya.2_Translation_Start_Site|TDP1_uc001xyb.2_RNA|TDP1_uc010ato.2_Missense_Mutation_p.I110M|TDP1_uc001xyc.1_Missense_Mutation_p.I110M	NM_018319	NP_060789	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	110					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		AAGTGGTGATCAAAAAGGAGA	0.542		NaN						Repair_of_DNA-protein_crosslinks					0	0	0	0.004656	0	24	53									
GPR68	8111	broad.mit.edu	37	14	91701248	91701248	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:91701248C>G	uc001xzg.2	-	2	488	c.147G>C	c.(145-147)CAG>CAC	p.Q49H	GPR68_uc001xzh.2_Missense_Mutation_p.Q59H	NM_003485	NP_003476	Q15743	OGR1_HUMAN	G protein-coupled receptor 68	49	Cytoplasmic (Potential).				inflammatory response	integral to plasma membrane	G-protein coupled receptor activity	p.N49S(1)		kidney(1)	1		all_cancers(154;0.0555)		COAD - Colon adenocarcinoma(157;0.21)		GGGCCTTGATCTGCAGGTAGC	0.622		NaN											0	0	0	0.010504	0	15	32									
TRIP11	9321	broad.mit.edu	37	14	92471718	92471718	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:92471718C>G	uc001xzy.2	-	11	3390	c.2602G>C	c.(2602-2604)GAA>CAA	p.E868Q	TRIP11_uc010auf.1_Missense_Mutation_p.E604Q	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	868	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		CGTTCCAATTCTTCTTGCAGA	0.418		NaN	T	PDGFRB	AML								0	0	0	0.004656	0	24	68									
HSP90AA1	3320	broad.mit.edu	37	14	102551299	102551299	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:102551299C>A	uc001yku.3	-	5	890	c.700G>T	c.(700-702)GAG>TAG	p.E234*	HSP90AA1_uc001ykv.3_Nonsense_Mutation_p.E356*|HSP90AA1_uc001ykw.1_Nonsense_Mutation_p.E55*|HSP90AA1_uc001ykx.1_Nonsense_Mutation_p.E223*	NM_005348	NP_005339	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 2	234					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	tcttcAGCCTCATCATCGCTT	0.323		NaN											1	0	2.80697e-09	0.010729	2.99719e-09	11	26									
HSP90AA1	3320	broad.mit.edu	37	14	102552620	102552620	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:102552620C>G	uc001yku.3	-	2	286	c.96G>C	c.(94-96)TTG>TTC	p.L32F	HSP90AA1_uc001ykv.3_Missense_Mutation_p.L154F|HSP90AA1_uc001ykw.1_5'UTR|HSP90AA1_uc001ykx.1_Missense_Mutation_p.L21F	NM_005348	NP_005339	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 2	32					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	TATTGATGATCAATGACATCA	0.443		NaN											0	0	0	0.005443	0	27	71									
INF2	64423	broad.mit.edu	37	14	105172458	105172458	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:105172458C>G	uc001ypb.2	+	6	931	c.788C>G	c.(787-789)TCT>TGT	p.S263C	INF2_uc010tyi.1_Missense_Mutation_p.S263C|INF2_uc001ypc.2_Missense_Mutation_p.S263C|INF2_uc010awz.1_5'Flank	NM_022489	NP_071934	Q27J81	INF2_HUMAN	inverted formin 2 isoform 1	263	GBD/FH3.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding				0		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		CTGCGAGTCTCTGGCGGGGTC	0.672		NaN											0	0	0	0.006214	0	8	14									
INF2	64423	broad.mit.edu	37	14	105173276	105173276	+	Silent	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:105173276C>G	uc001ypb.2	+	7	1016	c.873C>G	c.(871-873)CTC>CTG	p.L291L	INF2_uc010tyi.1_Silent_p.L291L|INF2_uc001ypc.2_Silent_p.L291L|INF2_uc010awz.1_5'Flank	NM_022489	NP_071934	Q27J81	INF2_HUMAN	inverted formin 2 isoform 1	291	GBD/FH3.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding				0		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		CTGCCCAGCTCCTGTCGGTGC	0.706		NaN											0	0	0	0.007413	0	15	22									
INF2	64423	broad.mit.edu	37	14	105174062	105174062	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:105174062C>G	uc001ypb.2	+	8	1601	c.1458C>G	c.(1456-1458)TTC>TTG	p.F486L	INF2_uc010tyi.1_Missense_Mutation_p.F486L|INF2_uc001ypc.2_Missense_Mutation_p.F486L|INF2_uc010awz.1_RNA	NM_022489	NP_071934	Q27J81	INF2_HUMAN	inverted formin 2 isoform 1	486	Pro-rich.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding				0		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		cctgtgagttcctgcccccac	0.179		NaN											0	0	0	0.004672	0	2	0									
INF2	64423	broad.mit.edu	37	14	105174218	105174218	+	Silent	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr14:105174218C>A	uc001ypb.2	+	8	1757	c.1614C>A	c.(1612-1614)ATC>ATA	p.I538I	INF2_uc010tyi.1_Silent_p.I538I|INF2_uc001ypc.2_Silent_p.I538I|INF2_uc010awz.1_RNA	NM_022489	NP_071934	Q27J81	INF2_HUMAN	inverted formin 2 isoform 1	538					actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding				0		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		AGGAGGTCATCGTGGCCCAGG	0.652		NaN											1	0	3.59834e-05	0.001168	3.73279e-05	5	23									
MTMR15	22909	broad.mit.edu	37	15	31197525	31197525	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:31197525C>G	uc001zff.2	+	2	950	c.659C>G	c.(658-660)TCT>TGT	p.S220C	MTMR15_uc001zfc.3_Missense_Mutation_p.S220C|MTMR15_uc010azw.2_Missense_Mutation_p.S220C|MTMR15_uc001zfd.3_Missense_Mutation_p.S220C|MTMR15_uc001zfe.2_5'UTR	NM_014967	NP_055782	Q9Y2M0	FAN1_HUMAN	myotubularin related protein 15 isoform a	220					double-strand break repair via homologous recombination|nucleotide-excision repair, DNA incision	nucleus	5'-3' exonuclease activity|5'-flap endonuclease activity|DNA binding|magnesium ion binding|phosphodiesterase I activity|ubiquitin binding				0		all_lung(180;2.23e-09)		all cancers(64;4.72e-15)|Epithelial(43;5.4e-11)|GBM - Glioblastoma multiforme(186;0.000136)|BRCA - Breast invasive adenocarcinoma(123;0.00402)|Lung(196;0.168)		AAATGTGATTCTCTAAAGGAA	0.393		NaN						Direct_reversal_of_damage|Editing_and_processing_nucleases					0	0	0	0.010504	0	20	38									
C15orf55	256646	broad.mit.edu	37	15	34645971	34645971	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:34645971C>A	uc001zif.2	+	4	1044	c.889C>A	c.(889-891)CAG>AAG	p.Q297K	C15orf55_uc010ucc.1_Missense_Mutation_p.Q325K|C15orf55_uc010ucd.1_Missense_Mutation_p.Q315K	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	297						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		GATGCAGATTCAGAACACACA	0.542		NaN	T	BRD3|BRD4	lethal midline carcinoma								1	0	6.14515e-18	0.01441	6.90293e-18	41	59									
LRRC57	255252	broad.mit.edu	37	15	42839461	42839461	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:42839461G>C	uc001zqd.1	-	3	858	c.490C>G	c.(490-492)CAG>GAG	p.Q164E	HAUS2_uc001zqe.2_5'Flank|HAUS2_uc010udi.1_5'Flank|HAUS2_uc001zqf.2_5'Flank|LRRC57_uc001zqc.2_Missense_Mutation_p.Q164E	NM_153260	NP_694992	Q8N9N7	LRC57_HUMAN	leucine rich repeat containing 57	164	LRR 6.										0		all_cancers(109;1.99e-12)|all_epithelial(112;5.11e-11)|Lung NSC(122;4.53e-07)|all_lung(180;1.64e-06)|Melanoma(134;0.0262)		GBM - Glioblastoma multiforme(94;6.87e-07)		CTCTAGACCTGATTCTGGTTG	0.443		NaN											0	0	0	0.010729	0	9	59									
DMXL2	23312	broad.mit.edu	37	15	51758463	51758463	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:51758463C>T	uc002abf.2	-	30	7660	c.7435G>A	c.(7435-7437)GAA>AAA	p.E2479K	DMXL2_uc002abd.2_Missense_Mutation_p.E550K|DMXL2_uc010ufy.1_Missense_Mutation_p.E2480K|DMXL2_uc010bfa.2_Missense_Mutation_p.E1843K	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2479						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TGAATGCTTTCATCAGAATCA	0.269		NaN											0	0	0	0.01441	0	37	68									
SLTM	79811	broad.mit.edu	37	15	59191829	59191829	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:59191829C>A	uc002afp.2	-	7	985	c.897G>T	c.(895-897)ATG>ATT	p.M299I	SLTM_uc002afo.2_Missense_Mutation_p.M281I|SLTM_uc002afq.2_Intron|SLTM_uc010bgd.2_Intron|SLTM_uc002afr.1_Missense_Mutation_p.M198I	NM_024755	NP_079031	Q9NWH9	SLTM_HUMAN	modulator of estrogen induced transcription	299					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)	1						GGTTCGCATTCATCTCATAAT	0.448		NaN											1	0	1.48734e-19	0.013114	1.70692e-19	37	118									
RBPMS2	348093	broad.mit.edu	37	15	65040670	65040670	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:65040670G>A	uc002anq.2	-	6	767	c.515C>T	c.(514-516)GCT>GTT	p.A172V		NM_194272	NP_919248	Q6ZRY4	RBPS2_HUMAN	RNA binding protein with multiple splicing 2	172							nucleic acid binding|nucleotide binding				0						GGTGAACGCAGCATGGGAGAT	0.622		NaN											0	0	0	0.007291	0	24	51									
IGDCC4	57722	broad.mit.edu	37	15	65680830	65680830	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:65680830G>C	uc002aou.1	-	16	3012	c.2802C>G	c.(2800-2802)TTC>TTG	p.F934L	IGDCC4_uc002aot.1_Missense_Mutation_p.F522L	NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	934	Extracellular (Potential).|Fibronectin type-III 5.					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						GCAGGCGGGAGAAAGGCCCAG	0.602		NaN											0	0	0	0.01441	0	59	169									
IGDCC4	57722	broad.mit.edu	37	15	65693281	65693281	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:65693281G>A	uc002aou.1	-	5	914	c.704C>T	c.(703-705)TCC>TTC	p.S235F		NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	235	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						GGACGCCAGGGACCCTGGCGA	0.408		NaN									OREG0023196	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.012213	0	29	62									
LCTL	197021	broad.mit.edu	37	15	66845384	66845384	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:66845384G>T	uc002aqc.2	-	9	1267	c.1135C>A	c.(1135-1137)CTG>ATG	p.L379M	LCTL_uc002aqd.3_Missense_Mutation_p.L206M|LCTL_uc010bhw.2_Missense_Mutation_p.L77M	NM_207338	NP_997221	Q6UWM7	LCTL_HUMAN	lactase-like precursor	379	Extracellular (Potential).				carbohydrate metabolic process	endoplasmic reticulum membrane|integral to membrane	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(2)	2						TTAGACCCCAGATCTGGCCAG	0.493		NaN											1	0	4.96729e-08	0.008871	5.26533e-08	16	100									
SMAD3	4088	broad.mit.edu	37	15	67457371	67457371	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:67457371G>A	uc002aqj.2	+	2	643	c.345G>A	c.(343-345)ATG>ATA	p.M115I	SMAD3_uc010ujr.1_Missense_Mutation_p.M10I|SMAD3_uc010ujs.1_Missense_Mutation_p.M71I|SMAD3_uc010ujt.1_5'Flank	NM_005902	NP_005893	P84022	SMAD3_HUMAN	mothers against decapentaplegic homolog 3	115	MH1.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			large_intestine(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		CCTTCAATATGAAGAAGGACG	0.602		NaN											0	0	0	0.007413	0	15	99									
HMG20A	10363	broad.mit.edu	37	15	77770687	77770687	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:77770687G>T	uc002bcr.2	+	9	943	c.742G>T	c.(742-744)GAG>TAG	p.E248*	HMG20A_uc002bcs.2_Nonsense_Mutation_p.E248*	NM_018200	NP_060670	Q9NP66	HM20A_HUMAN	high-mobility group 20A	248	Potential.				chromatin modification	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						GGAGTTTGAGGAGAGGAATGC	0.557		NaN											1	0	4.87955e-14	0.005443	5.34733e-14	26	64									
AKAP13	11214	broad.mit.edu	37	15	86064775	86064775	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:86064775C>T	uc002blv.1	+	3	320	c.150C>T	c.(148-150)GTC>GTT	p.V50V	AKAP13_uc002bls.2_Silent_p.V50V|AKAP13_uc002blt.1_Silent_p.V50V|AKAP13_uc002blu.1_Silent_p.V50V	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	50					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						CTCGGAAGGTCAGTTCTGATA	0.418		NaN											0	0	0	0.008871	0	17	103									
NTRK3	4916	broad.mit.edu	37	15	88576243	88576243	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:88576243G>C	uc002bme.1	-	13	1592	c.1430C>G	c.(1429-1431)TCA>TGA	p.S477*	NTRK3_uc002bmh.2_Nonsense_Mutation_p.S469*|NTRK3_uc002bmf.1_Nonsense_Mutation_p.S477*|NTRK3_uc010upl.1_Nonsense_Mutation_p.S379*|NTRK3_uc010bnh.1_Nonsense_Mutation_p.S469*|NTRK3_uc002bmg.2_Nonsense_Mutation_p.S477*|NTRK3_uc010bni.2_RNA	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	477	Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			TGGGCTGGCTGAGTCCTCCTC	0.622		NaN	T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			0	0	0	0.000602	0	5	12									
ANPEP	290	broad.mit.edu	37	15	90348336	90348336	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:90348336C>T	uc002bop.3	-	4	1162	c.870G>A	c.(868-870)GTG>GTA	p.V290V		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	290	Extracellular.|Interaction with HCoV-229E.|Metalloprotease.			DYVEKQAS->QSVEETAQ: No change in receptor activity and HCoV-229E infection.|DYVEKQAS->QSVNETAQ: Complete loss of receptor activity and blocks HCoV-229E infection. No loss of enzymatic activity.|DYVEKQAS->QSVNEQAQ: No change in receptor activity and HCoV-229E infection.	angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	CCTGCTTCTCCACGTAGTCGA	0.562		NaN											0	0	0	0.01441	0	45	105									
ANPEP	290	broad.mit.edu	37	15	90348636	90348636	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:90348636C>G	uc002bop.3	-	3	965	c.673G>C	c.(673-675)GAT>CAT	p.D225H		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	225	Extracellular.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	GCCGGCTCATCGAAGCATGGG	0.607		NaN											0	0	0	0.00632	0	24	34									
IQGAP1	8826	broad.mit.edu	37	15	91020904	91020904	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:91020904G>A	uc002bpl.1	+	26	3213	c.3112G>A	c.(3112-3114)GTA>ATA	p.V1038I		NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	1038	Ras-GAP.|C1.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			TAGGTCGAAGGTAGATCAGAT	0.393		NaN											0	0	0	0.003163	0	15	68									
IQGAP1	8826	broad.mit.edu	37	15	91020921	91020921	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:91020921G>C	uc002bpl.1	+	26	3230	c.3129G>C	c.(3127-3129)GAG>GAC	p.E1043D		NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	1043	Ras-GAP.|C1.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			AGATTCAAGAGATTGTGACAG	0.413		NaN											0	0	0	0.010504	0	20	72									
SV2B	9899	broad.mit.edu	37	15	91835762	91835762	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:91835762C>G	uc002bqv.2	+	12	2423	c.2032C>G	c.(2032-2034)CGA>GGA	p.R678G	SV2B_uc010uqv.1_Missense_Mutation_p.R527G|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	678	Cytoplasmic (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			GCCAGAGACTCGAGAACAGGT	0.512		NaN											0	0	0	0.012319	0	18	105									
CHD2	1106	broad.mit.edu	37	15	93558002	93558002	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr15:93558002C>G	uc002bsp.2	+	37	5344	c.4769C>G	c.(4768-4770)TCT>TGT	p.S1590C	CHD2_uc002bso.1_Missense_Mutation_p.S1590C	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1590					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			AGCCGGGACTCTCTGATATCT	0.512		NaN											0	0	0	0.01441	0	57	102									
PIGQ	9091	broad.mit.edu	37	16	624461	624461	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:624461C>T	uc002cho.2	+	2	489	c.387C>T	c.(385-387)ATC>ATT	p.I129I	PIGQ_uc010bqw.2_Silent_p.I129I|PIGQ_uc002chm.2_Silent_p.I129I|PIGQ_uc002chn.2_Silent_p.I129I|PIGQ_uc010uui.1_Silent_p.I143I	NM_148920	NP_683721	Q9BRB3	PIGQ_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	129					C-terminal protein lipidation|carbohydrate metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			central_nervous_system(1)	1		Hepatocellular(780;0.00335)				TCATGCTCATCTTCTATGACC	0.692		NaN											0	0	0	0.00308	0	6	12									
FAM195A	84331	broad.mit.edu	37	16	697532	697532	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:697532T>A	uc002cic.1	+	3	441	c.298T>A	c.(298-300)TTT>ATT	p.F100I	FAM195A_uc002cid.1_Intron|FAM195A_uc002cie.2_Silent_p.A28A|FAM195A_uc002cif.1_RNA|WDR90_uc002cig.1_5'Flank|WDR90_uc002cih.1_5'Flank|WDR90_uc002cii.1_5'Flank|WDR90_uc002cij.1_5'Flank	NM_138418	NP_612427	Q9BUT9	F195A_HUMAN	hypothetical protein LOC84331	100											0						GAATGTCCGCTTTGTGTCCGA	0.637		NaN											0	0	0	0.006214	0	7	23									
MSLN	10232	broad.mit.edu	37	16	814666	814666	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:814666G>A	uc002cjw.1	+	6	371	c.320G>A	c.(319-321)CGG>CAG	p.R107Q	MSLN_uc002cjt.1_Missense_Mutation_p.R107Q|MSLN_uc002cju.1_Missense_Mutation_p.R107Q|MSLN_uc010brd.1_Missense_Mutation_p.R106Q|MSLN_uc002cjv.1_Missense_Mutation_p.R107Q|MSLN_uc002cjx.1_Missense_Mutation_p.R107Q|MSLN_uc002cjy.1_5'Flank	NM_013404	NP_037536	Q13421	MSLN_HUMAN	mesothelin isoform 2 preproprotein	107					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				pancreas(1)	1		Hepatocellular(780;0.00335)				CTGGCTCACCGGCTCTCTGAG	0.682		NaN											0	0	0	0.01441	0	53	127									
CORO7	79585	broad.mit.edu	37	16	4390379	4390379	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:4390379C>T	uc002cwf.2	-	31	3531	c.3088G>A	c.(3088-3090)GAG>AAG	p.E1030K	CORO7_uc002cwe.2_RNA|TIMM16_uc002cwd.2_Missense_Mutation_p.E107K	NM_024535	NP_078811	P57737	CORO7_HUMAN	coronin 7	Error:Variant_position_missing_in_P57737_after_alignment						cytoplasmic membrane-bounded vesicle|cytosol|Golgi membrane|integral to membrane of membrane fraction|soluble fraction					0						TTGAGTTCCTCATCCAGGCGC	0.622		NaN											0	0	0	0.004656	0	23	41									
ZKSCAN2	342357	broad.mit.edu	37	16	25251339	25251339	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:25251339C>G	uc002dod.3	-	7	3109	c.2702G>C	c.(2701-2703)AGA>ACA	p.R901T	ZKSCAN2_uc010vcl.1_Missense_Mutation_p.R697T	NM_001012981	NP_001012999	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	901	C2H2-type 5.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|breast(1)	4				GBM - Glioblastoma multiforme(48;0.0378)		TTCTCGAAATCTCGTACAGTT	0.458		NaN											0	0	0	0.003163	0	13	29									
APOB48R	55911	broad.mit.edu	37	16	28508751	28508751	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:28508751G>A	uc002dqb.1	+	3	2372	c.2362G>A	c.(2362-2364)GAG>AAG	p.E788K	uc010vct.1_Intron|APOB48R_uc010byg.1_Missense_Mutation_p.E326K	NM_018690	NP_061160	Q0VD83	APOBR_HUMAN	apolipoprotein B48 receptor	788	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle					0						AGAAAAGGAAGAGGCAGCAGC	0.572		NaN											0	0	0	0.001984	0	6	10									
ITGAX	3687	broad.mit.edu	37	16	31391116	31391116	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:31391116C>T	uc002ebu.1	+	25	2974	c.2907C>T	c.(2905-2907)ATC>ATT	p.I969I	ITGAX_uc002ebt.2_Silent_p.I969I	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	969	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CTGTCAGCATCAACTTCTGGG	0.617		NaN											0	0	0	0.010729	0	8	24									
CMTM2	146225	broad.mit.edu	37	16	66620940	66620940	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:66620940G>A	uc002ept.2	+	3	645	c.485G>A	c.(484-486)GGA>GAA	p.G162E	CMTM2_uc010cdu.2_Missense_Mutation_p.G109E	NM_144673	NP_653274	Q8TAZ6	CKLF2_HUMAN	chemokine-like factor superfamily 2	162	MARVEL.|Helical; (Potential).				chemotaxis	extracellular space|integral to membrane	cytokine activity			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.068)|Epithelial(162;0.212)		TTCCTTGTGGGAGCCGTGGTC	0.522		NaN											0	0	0	0.00499	0	14	87									
EXOC3L	283849	broad.mit.edu	37	16	67218811	67218811	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:67218811G>A	uc002erx.1	-	12	2140	c.1899C>T	c.(1897-1899)CTC>CTT	p.L633L	KIAA0895L_uc002ert.2_5'Flank|KIAA0895L_uc002eru.2_5'Flank|EXOC3L_uc002erv.1_RNA|EXOC3L_uc002erw.1_Silent_p.L284L|EXOC3L_uc002ery.1_Silent_p.L535L|EXOC3L_uc010vje.1_Silent_p.L530L	NM_178516	NP_848611	Q86VI1	EX3L1_HUMAN	exocyst complex component 3-like	633					exocytosis|peptide hormone secretion	exocyst|stored secretory granule|transport vesicle					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0021)|Epithelial(162;0.0073)|all cancers(182;0.0616)		TCACCAAACTGAGGAAAAGCT	0.687		NaN											0	0	0	0.004672	0	3	22									
AGRP	181	broad.mit.edu	37	16	67517183	67517183	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:67517183G>C	uc002etg.1	-	2	419	c.119C>G	c.(118-120)CCA>CGA	p.P40R	ATP6V0D1_uc002ete.1_5'Flank|ATP6V0D1_uc010vjo.1_5'Flank	NM_001138	NP_001129	O00253	AGRP_HUMAN	agouti related protein homolog isoform 1	40					hormone-mediated signaling pathway|neuropeptide signaling pathway|regulation of feeding behavior	extracellular space|Golgi lumen	neuropeptide hormone activity				0		Acute lymphoblastic leukemia(13;0.00263)|all_hematologic(13;0.0274)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0717)|Epithelial(162;0.16)		TGGGAGCTCTGGGAGCAGGGC	0.637		NaN											0	0	0	0.004672	0	3	4									
THAP11	57215	broad.mit.edu	37	16	67876898	67876898	+	Silent	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:67876898G>T	uc002euo.2	+	1	686	c.441G>T	c.(439-441)CCG>CCT	p.P147P	CENPT_uc002eun.3_Intron	NM_020457	NP_065190	Q96EK4	THA11_HUMAN	THAP domain containing 11	147					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00412)|Epithelial(162;0.018)|all cancers(182;0.118)		AGCTGCAGCCGAACCTGGTAT	0.468		NaN											1	0	2.56175e-15	0.01441	2.83935e-15	35	182									
EDC4	23644	broad.mit.edu	37	16	67917616	67917616	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:67917616G>C	uc002eur.2	+	28	4161	c.3995G>C	c.(3994-3996)CGA>CCA	p.R1332P	EDC4_uc010cer.2_Missense_Mutation_p.R951P|EDC4_uc002eus.2_Missense_Mutation_p.R1062P|EDC4_uc002eut.1_3'UTR|NRN1L_uc002euu.2_5'Flank	NM_014329	NP_055144	Q6P2E9	EDC4_HUMAN	autoantigen RCD8	1332					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|central_nervous_system(2)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		CTTGGCACTCGAACTGACCTC	0.617		NaN									OREG0023890	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	42	220									
SLC7A6	9057	broad.mit.edu	37	16	68308901	68308901	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:68308901C>G	uc002evt.1	+	4	581	c.272C>G	c.(271-273)TCT>TGT	p.S91C	SLC7A6_uc010cfb.1_RNA|SLC7A6_uc002evu.1_Missense_Mutation_p.S91C|SLC7A6_uc002evv.1_RNA|SLC7A6_uc010cfc.1_RNA	NM_001076785	NP_001070253	Q92536	YLAT2_HUMAN	solute carrier family 7 (cationic amino acid	91	Helical; (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|antiporter activity			central_nervous_system(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.0948)		GGGCTCTTCTCTGTTGTGGGT	0.547		NaN											0	0	0	0.010771	0	33	48									
HYDIN	54768	broad.mit.edu	37	16	71008159	71008159	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:71008159C>G	uc002ezr.2	-	33	5079	c.4951G>C	c.(4951-4953)GAA>CAA	p.E1651Q		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	1652										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				ATTTCCGTTTCACAATGAGGT	0.428		NaN											0	0	0	0.000602	0	4	20									
GLG1	2734	broad.mit.edu	37	16	74511362	74511362	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:74511362G>C	uc002fcy.3	-	12	1947	c.1897C>G	c.(1897-1899)CCT>GCT	p.P633A	GLG1_uc002fcx.2_Missense_Mutation_p.P633A|GLG1_uc002fcw.3_Missense_Mutation_p.P622A|GLG1_uc002fcz.3_Missense_Mutation_p.P50A	NM_001145667	NP_001139139	Q92896	GSLG1_HUMAN	golgi apparatus protein 1 isoform 3	633	Cys-rich GLG1 9.|Extracellular (Potential).					Golgi membrane|integral to membrane	receptor binding			ovary(1)|breast(1)	2						TGGAGGGCAGGATCCAGCTTG	0.483		NaN											0	0	0	0.01441	0	84	58									
RFWD3	55159	broad.mit.edu	37	16	74685877	74685877	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:74685877G>A	uc002fda.2	-	3	760	c.662C>T	c.(661-663)TCT>TTT	p.S221F	RFWD3_uc010cgq.2_Missense_Mutation_p.S221F	NM_018124	NP_060594	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	221				S -> P (in Ref. 1; BAF83889).	DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|breast(1)	3						ATACTCTGCAGAGCTGTCACT	0.468		NaN											0	0	0	0.01441	0	82	53									
ADAT1	23536	broad.mit.edu	37	16	75642774	75642774	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:75642774C>G	uc002feo.1	-	8	1258	c.1156G>C	c.(1156-1158)GAT>CAT	p.D386H	ADAT1_uc002fep.1_Missense_Mutation_p.D237H	NM_012091	NP_036223	Q9BUB4	ADAT1_HUMAN	adenosine deaminase, tRNA-specific 1	386	A to I editase.				tRNA processing		metal ion binding|RNA binding|tRNA-specific adenosine deaminase activity			ovary(1)|skin(1)	2						CCTGGGCTATCAGCCCTTTTT	0.512		NaN											0	0	0	0.005443	0	23	57									
TERF2IP	54386	broad.mit.edu	37	16	75681873	75681873	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:75681873C>G	uc002fet.1	+	1	190	c.93C>G	c.(91-93)TTC>TTG	p.F31L	KARS_uc002fer.2_5'Flank|KARS_uc002feq.2_5'Flank|KARS_uc002fes.2_5'Flank|KARS_uc010cha.1_Intron	NM_018975	NP_061848	Q9NYB0	TE2IP_HUMAN	telomeric repeat binding factor 2, interacting	31					negative regulation of DNA recombination at telomere|negative regulation of telomere maintenance|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|regulation of double-strand break repair via homologous recombination|telomere maintenance via telomerase|transcription, DNA-dependent	cytoplasm|nuclear telomere cap complex|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1						CCATGTCCTTCTACGTGCGGC	0.682		NaN											0	0	0	0.001855	0	12	52									
MLYCD	23417	broad.mit.edu	37	16	83948929	83948929	+	Silent	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:83948929G>T	uc002fgz.2	+	5	1337	c.1317G>T	c.(1315-1317)GTG>GTT	p.V439V		NM_012213	NP_036345	O95822	DCMC_HUMAN	malonyl-CoA decarboxylase precursor	439					acyl-CoA metabolic process|fatty acid biosynthetic process	mitochondrion|peroxisome	malonyl-CoA decarboxylase activity|methylmalonyl-CoA decarboxylase activity				0						TGGCGGATGTGAGCCTCAGAG	0.637		NaN											1	0	1.799e-87	0.01441	2.11455e-87	121	71									
FOXC2	2303	broad.mit.edu	37	16	86601504	86601504	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:86601504C>T	uc002fjq.2	+	1	648	c.563C>T	c.(562-564)CCG>CTG	p.P188L		NM_005251	NP_005242	Q99958	FOXC2_HUMAN	forkhead box C2	188					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|embryonic viscerocranium morphogenesis|insulin receptor signaling pathway|lymphangiogenesis|metanephros development|negative regulation of transcription from RNA polymerase II promoter|neural crest cell fate commitment|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of cell adhesion mediated by integrin|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vascular wound healing|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding|transcription regulatory region DNA binding				0						GAGCCGCCCCCGGCGGCGTCC	0.701		NaN							Late-onset_Hereditary_Lymphedema				0	0	0	0.008291	0	7	18									
SPATA2L	124044	broad.mit.edu	37	16	89763774	89763774	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:89763774G>C	uc002foj.2	-	3	1308	c.1243C>G	c.(1243-1245)CTG>GTG	p.L415V	SPATA2L_uc002fok.2_Intron	NM_152339	NP_689552	Q8IUW3	SPA2L_HUMAN	spermatogenesis associated 2-like	415											0		Lung NSC(15;0.00043)|all_lung(18;0.000665)|all_hematologic(23;0.0355)		BRCA - Breast invasive adenocarcinoma(80;0.0272)		TTGTAGAGCAGAGTGTCCATC	0.687		NaN											0	0	0	0.009096	0	4	14									
FANCA	2175	broad.mit.edu	37	16	89807249	89807249	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr16:89807249G>T	uc002fou.1	-	38	3833	c.3791C>A	c.(3790-3792)TCC>TAC	p.S1264Y	ZNF276_uc010ciq.2_3'UTR|ZNF276_uc002foq.3_3'UTR|ZNF276_uc010cir.2_RNA|ZNF276_uc002for.3_3'UTR|ZNF276_uc010cis.2_3'UTR|ZNF276_uc002fos.3_3'UTR|ZNF276_uc002fot.3_RNA|ZNF276_uc010vpm.1_3'UTR|FANCA_uc010vpn.1_Missense_Mutation_p.S1264Y|FANCA_uc010vpo.1_Missense_Mutation_p.S350Y	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	1264					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		GCCCATCAAGGAGAAGAAGAA	0.453		NaN	D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				1	0	1.2644e-06	0.010504	1.32581e-06	18	22									
ZZEF1	23140	broad.mit.edu	37	17	3984727	3984727	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:3984727C>T	uc002fxe.2	-	18	2836	c.2772G>A	c.(2770-2772)ATG>ATA	p.M924I	ZZEF1_uc002fxk.1_Missense_Mutation_p.M925I	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	924							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CACTGATGTTCATCTTGGCCA	0.498		NaN											0	0	0	0.01441	0	44	50									
ZZEF1	23140	broad.mit.edu	37	17	4045961	4045961	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:4045961G>A	uc002fxe.2	-	1	293	c.229C>T	c.(229-231)CGC>TGC	p.R77C	ZZEF1_uc002fxk.1_Missense_Mutation_p.R77C|CYB5D2_uc002fxm.3_5'Flank|CYB5D2_uc010cko.2_5'Flank|CYB5D2_uc002fxl.3_5'Flank	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	77							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						AACGCGCCGCGATGCCTCGAC	0.721		NaN											0	0	0	0.008291	0	8	11									
USP6	9098	broad.mit.edu	37	17	5041507	5041507	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:5041507C>T	uc002gau.1	+	21	3247	c.1017C>T	c.(1015-1017)CTC>CTT	p.L339L	USP6_uc002gav.1_Silent_p.L339L|USP6_uc010ckz.1_5'UTR|uc002gbd.2_5'Flank	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	339					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						ACACCGTGCTCAAGCATCTTA	0.577		NaN	T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								0	0	0	0.010818	0	30	93									
PITPNM3	83394	broad.mit.edu	37	17	6374547	6374547	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:6374547C>A	uc002gdd.3	-	12	1709	c.1558G>T	c.(1558-1560)GAG>TAG	p.E520*	PITPNM3_uc010cln.2_Nonsense_Mutation_p.E484*|PITPNM3_uc010clm.2_Nonsense_Mutation_p.E3*|PITPNM3_uc002gdc.3_Nonsense_Mutation_p.E111*	NM_031220	NP_112497	Q9BZ71	PITM3_HUMAN	PITPNM family member 3 isoform 1	520	DDHD.				phosphatidylinositol metabolic process	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			ovary(2)|central_nervous_system(2)	4				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)		GAGCTCCCCTCGCTCATCCTC	0.687		NaN											1	0	0.00448238	0.004482	0.00460075	7	18									
ASGR2	433	broad.mit.edu	37	17	7010563	7010563	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:7010563G>A	uc002gep.3	-	6	763	c.498C>T	c.(496-498)CTC>CTT	p.L166L	ASGR2_uc010vtk.1_Silent_p.L3L|ASGR2_uc002gem.1_Silent_p.L105L|ASGR2_uc002gen.1_Silent_p.L147L|ASGR2_uc002geo.1_Silent_p.L161L|ASGR2_uc002ger.3_Silent_p.L166L|ASGR2_uc002geq.3_Silent_p.L142L	NM_001181	NP_001172	P07307	ASGR2_HUMAN	asialoglycoprotein receptor 2 isoform a	166	Extracellular (Potential).				cell surface receptor linked signaling pathway|endocytosis	focal adhesion|integral to membrane|nucleolus	asialoglycoprotein receptor activity|protein binding|sugar binding			ovary(1)	1					Antihemophilic Factor(DB00025)	TGCTGTGGAGGAGCTCCATCT	0.642		NaN											0	0	0	0.010729	0	10	14									
MYH3	4621	broad.mit.edu	37	17	10539066	10539067	+	Missense_Mutation	DNP	CC	CC	TT			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:10539066_10539067CC>TT	uc002gmq.1	-	28	4037_4038	c.3960_3961GG>AA	c.(3958-3963)CTGGAG>CTAAAG	p.E1321K		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1321	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						TTCTCTTCCTCCAGCTGCCTCT	0.426		NaN											0	0	0	0.004672	0	52	77									
PIP4K2B	8396	broad.mit.edu	37	17	36935741	36935741	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:36935741G>C	uc002hqs.2	-	5	1030	c.549C>G	c.(547-549)TTC>TTG	p.F183L	PIP4K2B_uc010wdt.1_Missense_Mutation_p.F183L|PIP4K2B_uc010wdu.1_Missense_Mutation_p.F119L	NM_003559	NP_003550	P78356	PI42B_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	183	PIPK.				cell surface receptor linked signaling pathway	endoplasmic reticulum membrane|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|receptor signaling protein activity			ovary(1)	1						ACATGCCCAGGAACTGTGGCA	0.522		NaN											0	0	0	0.00499	0	17	42									
MED24	9862	broad.mit.edu	37	17	38192035	38192035	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:38192035G>A	uc002htt.2	-	5	579	c.266C>T	c.(265-267)TCT>TTT	p.S89F	MED24_uc010wes.1_5'Flank|MED24_uc010wet.1_RNA|MED24_uc002hts.2_Missense_Mutation_p.S114F|MED24_uc002htu.2_Missense_Mutation_p.S76F|MED24_uc010cwn.2_Missense_Mutation_p.S76F|MED24_uc010weu.1_Intron|MED24_uc010wev.1_Missense_Mutation_p.S39F|MED24_uc010wew.1_Missense_Mutation_p.S18F|MED24_uc010wex.1_Intron|MED24_uc010wez.1_5'Flank|MED24_uc010wfa.1_Missense_Mutation_p.S39F|MED24_uc010wfb.1_Missense_Mutation_p.S101F|MED24_uc010wfc.1_Missense_Mutation_p.S26F	NM_014815	NP_055630	O75448	MED24_HUMAN	mediator complex subunit 24 isoform 1	89					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1	Colorectal(19;0.000442)					CAGGTCCCGAGAAAAGTCATC	0.532		NaN											0	0	0	0.004482	0	8	47									
NR1D1	9572	broad.mit.edu	37	17	38253600	38253600	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:38253600C>G	uc002htz.1	-	2	714	c.88G>C	c.(88-90)GAA>CAA	p.E30Q	NR1D1_uc010cwq.1_RNA|NR1D1_uc010cwr.1_5'Flank	NM_021724	NP_068370	P20393	NR1D1_HUMAN	nuclear receptor subfamily 1, group D, member 1	30					cellular response to lipopolysaccharide|negative regulation of receptor biosynthetic process|negative regulation of toll-like receptor 4 signaling pathway|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			skin(1)	1	Colorectal(19;0.000442)					TAGAGGGATTCAGGGCTGGTG	0.587		NaN											0	0	0	0.010504	0	17	22									
CASC3	22794	broad.mit.edu	37	17	38297460	38297460	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:38297460G>T	uc010cwt.1	+	2	527	c.232G>T	c.(232-234)GAG>TAG	p.E78*	CASC3_uc010cws.1_Nonsense_Mutation_p.E78*|CASC3_uc002hue.2_Nonsense_Mutation_p.E78*	NM_007359	NP_031385	O15234	CASC3_HUMAN	metastatic lymph node 51	78					mRNA processing|mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|response to stress|RNA splicing	exon-exon junction complex|nuclear speck|perinuclear region of cytoplasm	identical protein binding|RNA binding|ubiquitin protein ligase binding			ovary(1)	1						TTTCTTTCAGGAGAGTGAAGA	0.403		NaN											1	0	2.6465e-34	0.01441	3.09821e-34	59	86									
TOP2A	7153	broad.mit.edu	37	17	38569453	38569453	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:38569453G>C	uc002huq.2	-	6	696	c.570C>G	c.(568-570)TTC>TTG	p.F190L	TOP2A_uc002hur.1_5'Flank	NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	190					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	TTGCCTGTTTGAACATTTTCT	0.328		NaN											0	0	0	0.004672	0	2	5									
KRT12	3859	broad.mit.edu	37	17	39017927	39017927	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:39017927C>T	uc002hvk.2	-	8	1495	c.1471G>A	c.(1471-1473)GAA>AAA	p.E491K		NM_000223	NP_000214	Q99456	K1C12_HUMAN	keratin 12	491	Tail.				visual perception	intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				ATTAGTTCTTCAATTTCCTGA	0.373		NaN											0	0	0	0.003163	0	9	57									
KRT12	3859	broad.mit.edu	37	17	39017933	39017933	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:39017933C>A	uc002hvk.2	-	8	1489	c.1465G>T	c.(1465-1467)GAA>TAA	p.E489*		NM_000223	NP_000214	Q99456	K1C12_HUMAN	keratin 12	489	Tail.				visual perception	intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				TCTTCAATTTCCTGAACTTGA	0.368		NaN											1	0	6.31663e-08	0.003163	6.67136e-08	11	65									
FAM134C	162427	broad.mit.edu	37	17	40733844	40733844	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:40733844G>C	uc002ial.2	-	9	1491	c.1388C>G	c.(1387-1389)TCT>TGT	p.S463C	FAM134C_uc010wgq.1_Missense_Mutation_p.S263C|FAM134C_uc002iam.1_Missense_Mutation_p.S263C|FAM134C_uc010cyk.1_Missense_Mutation_p.S366C	NM_178126	NP_835227	Q86VR2	F134C_HUMAN	hypothetical protein LOC162427	463						integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.134)		GTGGCTCCTAGAACTGGCAGG	0.547		NaN											0	0	0	0.007413	0	16	34									
ADAM11	4185	broad.mit.edu	37	17	42849819	42849819	+	Silent	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:42849819G>C	uc002ihh.2	+	8	663	c.663G>C	c.(661-663)CTG>CTC	p.L221L	ADAM11_uc010wjd.1_Missense_Mutation_p.E23Q	NM_002390	NP_002381	O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11 preproprotein	221					integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			pancreas(1)	1		Prostate(33;0.0959)				GGCCGAGGCTGAGAAGGAAAA	0.706		NaN											0	0	0	0.004672	0	3	7									
PLEKHM1	9842	broad.mit.edu	37	17	43522898	43522898	+	Silent	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:43522898C>G	uc002ija.2	-	9	2945	c.2775G>C	c.(2773-2775)CTG>CTC	p.L925L	PLEKHM1_uc010wjm.1_Silent_p.L897L|PLEKHM1_uc002ijb.2_Silent_p.L400L|PLEKHM1_uc010wjn.1_Silent_p.L874L	NM_014798	NP_055613	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M	925					intracellular signal transduction	cytoplasm	metal ion binding				0	Renal(3;0.0405)					CCAGGAGCTTCAGCTGCTCCC	0.592		NaN											0	0	0	0.006122	0	17	57									
MYCBPAP	84073	broad.mit.edu	37	17	48604701	48604701	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:48604701C>T	uc010wmr.1	+	15	2514	c.2352C>T	c.(2350-2352)CTC>CTT	p.L784L	MYCBPAP_uc002iqz.2_RNA	NM_032133	NP_115509	Q8TBZ2	MYBPP_HUMAN	Myc-binding protein-associated protein	747					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			urinary_tract(2)|skin(2)|ovary(1)|pancreas(1)	6	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			TGATGAGGCTCAACAAAGCAG	0.592		NaN											0	0	0	0.010504	0	20	119									
CACNA1G	8913	broad.mit.edu	37	17	48655779	48655779	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:48655779G>C	uc002irk.1	+	9	2527	c.2155G>C	c.(2155-2157)GAT>CAT	p.D719H	CACNA1G_uc002iri.1_Missense_Mutation_p.D719H|CACNA1G_uc002irj.1_Missense_Mutation_p.D719H|CACNA1G_uc002irl.1_Missense_Mutation_p.D719H|CACNA1G_uc002irm.1_Missense_Mutation_p.D719H|CACNA1G_uc002irn.1_Missense_Mutation_p.D719H|CACNA1G_uc002iro.1_Missense_Mutation_p.D719H|CACNA1G_uc002irp.1_Missense_Mutation_p.D719H|CACNA1G_uc002irq.1_Missense_Mutation_p.D719H|CACNA1G_uc002irr.1_Missense_Mutation_p.D719H|CACNA1G_uc002irs.1_Missense_Mutation_p.D719H|CACNA1G_uc002irt.1_Missense_Mutation_p.D719H|CACNA1G_uc002irv.1_Missense_Mutation_p.D719H|CACNA1G_uc002irw.1_Missense_Mutation_p.D719H|CACNA1G_uc002iru.1_Missense_Mutation_p.D719H|CACNA1G_uc002irx.1_Missense_Mutation_p.D632H|CACNA1G_uc002iry.1_Missense_Mutation_p.D632H|CACNA1G_uc002irz.1_Missense_Mutation_p.D632H|CACNA1G_uc002isa.1_Missense_Mutation_p.D632H|CACNA1G_uc002isb.1_Missense_Mutation_p.D632H|CACNA1G_uc002isc.1_Missense_Mutation_p.D632H|CACNA1G_uc002isd.1_Missense_Mutation_p.D632H|CACNA1G_uc002ise.1_Missense_Mutation_p.D632H|CACNA1G_uc002isf.1_Missense_Mutation_p.D632H|CACNA1G_uc002isg.1_Missense_Mutation_p.D632H|CACNA1G_uc002ish.1_Missense_Mutation_p.D632H|CACNA1G_uc002isi.1_Missense_Mutation_p.D632H	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	719	Cytoplasmic (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CCTGGGCCCAGATGCAGAGCC	0.602		NaN											0	0	0	0.004007	0	17	61									
HEATR6	63897	broad.mit.edu	37	17	58123500	58123500	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:58123500C>G	uc002iyk.1	-	19	2877	c.2860G>C	c.(2860-2862)GAG>CAG	p.E954Q	HEATR6_uc010ddk.1_Missense_Mutation_p.E493Q|HEATR6_uc010wos.1_Missense_Mutation_p.E674Q	NM_022070	NP_071353	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	954							binding			ovary(1)|skin(1)	2	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			ATAGACTCCTCAATGATTTCT	0.393		NaN											0	0	0	0.008361	0	25	62									
HEATR6	63897	broad.mit.edu	37	17	58156241	58156241	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:58156241G>A	uc002iyk.1	-	1	52	c.35C>T	c.(34-36)TCC>TTC	p.S12F		NM_022070	NP_071353	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	12							binding			ovary(1)|skin(1)	2	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			CGGCTGCACGGAAGGCCACGA	0.652		NaN											0	0	0	0.000602	0	4	26									
GH1	2688	broad.mit.edu	37	17	61994708	61994708	+	Silent	SNP	G	G	A	rs148474991		TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:61994708G>A	uc002jdj.2	-	5	677	c.615C>T	c.(613-615)ATC>ATT	p.I205I	GH1_uc002jdi.2_Silent_p.I190I|GH1_uc002jdk.2_Silent_p.I165I|GH1_uc002jdl.2_Silent_p.I110I|GH1_uc002jdm.2_3'UTR|GH1_uc002jdn.2_Missense_Mutation_p.S159L	NM_000515	NP_000506	P01241	SOMA_HUMAN	growth hormone 1 isoform 1	205			I -> M (in short stature; idiopathic autosomal).		glucose transport|growth hormone receptor signaling pathway|JAK-STAT cascade|positive regulation of activation of JAK2 kinase activity|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of MAP kinase activity|positive regulation of multicellular organism growth|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|response to estradiol stimulus	extracellular space	growth factor activity|growth hormone receptor binding|hormone activity|metal ion binding|prolactin receptor binding				0						GGCACTGCACGATGCGCAGGA	0.592		NaN											0	0	0	0.008361	0	25	61									
LRRC37A3	374819	broad.mit.edu	37	17	62854903	62854903	+	Silent	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:62854903G>C	uc002jey.2	-	12	5334	c.4803C>G	c.(4801-4803)CTC>CTG	p.L1601L	LRRC37A3_uc010wqg.1_Silent_p.L719L|LRRC37A3_uc002jex.1_Silent_p.L578L|LRRC37A3_uc010wqf.1_Silent_p.L639L	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1601	Helical; (Potential).					integral to membrane					0						TTACCTCAATGAGGCAGAGAA	0.383		NaN											0	0	0	0.007413	0	20	57									
ABCA6	23460	broad.mit.edu	37	17	67132242	67132242	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:67132242C>G	uc002jhw.1	-	4	626	c.451G>C	c.(451-453)GAT>CAT	p.D151H	ABCA6_uc002jhy.2_Missense_Mutation_p.D149H	NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	151					transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					CCTGAGAAATCTTCTTTCCAA	0.323		NaN											0	0	0	0.001168	0	5	31									
CD300LF	146722	broad.mit.edu	37	17	72699199	72699199	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:72699199G>C	uc002jlg.2	-	3	524	c.421C>G	c.(421-423)CTG>GTG	p.L141V	RAB37_uc002jlc.2_Intron|RAB37_uc010dfu.2_Intron|RAB37_uc002jld.2_Intron|CD300LF_uc002jlf.2_Missense_Mutation_p.L144V|CD300LF_uc010dfw.2_RNA|CD300LF_uc002jlh.2_Missense_Mutation_p.L141V|CD300LF_uc002jli.2_Missense_Mutation_p.L144V|CD300LF_uc010wra.1_Missense_Mutation_p.L156V|CD300LF_uc002jlj.1_Missense_Mutation_p.L159V	NM_139018	NP_620587	Q8TDQ1	CLM1_HUMAN	NK inhibitory receptor precursor	141	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			upper_aerodigestive_tract(1)	1						TGGCCGGTCAGAGTTGGGGAG	0.547		NaN											0	0	0	0.001855	0	11	104									
CDK3	1018	broad.mit.edu	37	17	73998125	73998125	+	Missense_Mutation	SNP	G	G	C	rs140567861		TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:73998125G>C	uc010dgt.2	+	4	293	c.217G>C	c.(217-219)GAG>CAG	p.E73Q	CDK3_uc002jqg.3_Missense_Mutation_p.E101Q	NM_001258	NP_001249	Q00526	CDK3_HUMAN	cyclin-dependent kinase 3	73	Protein kinase.				cell division|cell proliferation|mitosis		ATP binding|cyclin-dependent protein kinase activity			central_nervous_system(1)	1						GGTGCACAACGAGAGGAAGCT	0.572		NaN											0	0	0	0.006122	0	14	68									
C17orf70	80233	broad.mit.edu	37	17	79517599	79517599	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:79517599C>T	uc002kaq.2	-	3	976	c.921G>A	c.(919-921)GTG>GTA	p.V307V	C17orf70_uc002kao.1_5'Flank|C17orf70_uc010wuq.1_RNA|C17orf70_uc002kap.2_Silent_p.V156V	NM_001109760	NP_001103230	Q0VG06	FP100_HUMAN	Fanconi anemia core complex 100 kDa subunit	307					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			ovary(1)|skin(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			AGTCACAGTGCACATCCTCGT	0.607		NaN											0	0	0	0.004007	0	12	74									
CD7	924	broad.mit.edu	37	17	80274738	80274738	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr17:80274738C>G	uc002kel.1	-	2	311	c.202G>C	c.(202-204)GAC>CAC	p.D68H	CD7_uc010din.2_Missense_Mutation_p.D68H|CD7_uc002kem.2_Missense_Mutation_p.R49T|CD7_uc010wvk.1_Missense_Mutation_p.D68H	NM_006137	NP_006128	P09564	CD7_HUMAN	CD7 antigen precursor	68	Ig-like.|Extracellular (Probable).				immune response|T cell activation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|membrane fraction|plasma membrane	receptor activity				0	Breast(20;0.000675)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.249)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0667)			TAAATGATGTCTTGGGGCTGT	0.632		NaN											0	0	0	0.00632	0	24	55									
SLC14A2	8170	broad.mit.edu	37	18	43206949	43206949	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr18:43206949G>C	uc010dnj.2	+	5	679	c.358G>C	c.(358-360)GAC>CAC	p.D120H	SLC14A2_uc002lbb.2_Missense_Mutation_p.D120H|SLC14A2_uc002lbe.2_Missense_Mutation_p.D120H	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	120						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						CCAGTTCATAGACTGGGTCCT	0.557		NaN											0	0	0	0.012319	0	18	78									
SLC14A2	8170	broad.mit.edu	37	18	43216988	43216988	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr18:43216988C>T	uc010dnj.2	+	7	1005	c.684C>T	c.(682-684)TTC>TTT	p.F228F	SLC14A2_uc002lbb.2_Silent_p.F228F|SLC14A2_uc002lbe.2_Silent_p.F228F	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	228						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						ATTCCATCTTCAGCAAGTGGG	0.512		NaN											0	0	0	0.01441	0	107	236									
C18orf25	147339	broad.mit.edu	37	18	43842948	43842948	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr18:43842948C>T	uc002lbw.2	+	6	1461	c.1082C>T	c.(1081-1083)TCG>TTG	p.S361L	C18orf25_uc002lbx.2_Missense_Mutation_p.S300L	NM_145055	NP_659492	Q96B23	CR025_HUMAN	ARKadia-like 1 isoform a	360										central_nervous_system(2)	2						AAGCATGGCTCGGGCACGCAG	0.493		NaN											0	0	0	0.005443	0	19	113									
ATP8B1	5205	broad.mit.edu	37	18	55351301	55351301	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr18:55351301C>G	uc002lgw.2	-	14	1597	c.1597G>C	c.(1597-1599)GTT>CTT	p.V533L	uc002lgv.1_Intron	NM_005603	NP_005594	O43520	AT8B1_HUMAN	ATPase, class I, type 8B, member 1	533	Cytoplasmic (Potential).				ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)				GTGTGGCAAACTGCGAGCAAG	0.448		NaN							Byler_disease				0	0	0	0.006122	0	13	69									
ATP8B1	5205	broad.mit.edu	37	18	55351394	55351394	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr18:55351394C>T	uc002lgw.2	-	14	1504	c.1504G>A	c.(1504-1506)GAT>AAT	p.D502N	uc002lgv.1_Intron	NM_005603	NP_005594	O43520	AT8B1_HUMAN	ATPase, class I, type 8B, member 1	502	Cytoplasmic (Potential).				ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)				AGCTTCCCATCAGCATATGTA	0.348		NaN							Byler_disease				0	0	0	0.008291	0	9	33									
MC4R	4160	broad.mit.edu	37	18	58038833	58038833	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr18:58038833C>T	uc002lie.1	-	1	1169	c.750G>A	c.(748-750)CTG>CTA	p.L250L		NM_005912	NP_005903	P32245	MC4R_HUMAN	melanocortin 4 receptor	250	Helical; Name=6; (Potential).				feeding behavior|G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of bone resorption|positive regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|ubiquitin protein ligase binding			lung(1)	1		Colorectal(73;0.0946)				AGACGCCAATCAGGATGGTCA	0.498		NaN											0	0	0	0.005443	0	23	29									
ZNF555	148254	broad.mit.edu	37	19	2852858	2852858	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:2852858C>A	uc002lwo.2	+	4	884	c.795C>A	c.(793-795)TTC>TTA	p.F265L	ZNF555_uc002lwn.3_Missense_Mutation_p.F264L	NM_152791	NP_690004	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	265	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAAAGCTTTCAGTTATTCCT	0.408		NaN											1	0	9.70103e-10	0.008291	1.03774e-09	9	50									
PLIN3	10226	broad.mit.edu	37	19	4859922	4859922	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:4859922C>T	uc002mbj.2	-	3	358	c.181G>A	c.(181-183)GAC>AAC	p.D61N	PLIN3_uc002mbk.2_Missense_Mutation_p.D61N|PLIN3_uc002mbl.3_Missense_Mutation_p.D61N	NM_005817	NP_005808	O60664	PLIN3_HUMAN	mannose 6 phosphate receptor binding protein 1	61					vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding				0					Galsulfase(DB01279)|Idursulfase(DB01271)	TCTGCTGCGTCGCAGACAGTC	0.637		NaN											0	0	0	0.000602	0	3	25									
GTF2F1	2962	broad.mit.edu	37	19	6392882	6392882	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:6392882G>A	uc002meq.2	-	2	330	c.45C>T	c.(43-45)GTC>GTT	p.V15V	GTF2F1_uc010xjc.1_5'Flank	NM_002096	NP_002087	P35269	T2FA_HUMAN	general transcription factor IIF, polypeptide 1,	15					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|response to virus|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cell junction|transcription factor TFIIF complex	catalytic activity|DNA binding|phosphatase activator activity|transcription coactivator activity|transcription factor binding				0						GAACTCGAACGACGTATTCAG	0.587		NaN									OREG0025199	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	44	186									
ANGPTL4	51129	broad.mit.edu	37	19	8436324	8436324	+	Silent	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:8436324C>G	uc002mjq.1	+	6	1152	c.957C>G	c.(955-957)CCC>CCG	p.P319P	ANGPTL4_uc002mjr.1_Silent_p.P281P|ANGPTL4_uc010xkc.1_Silent_p.P152P	NM_139314	NP_647475	Q9BY76	ANGL4_HUMAN	angiopoietin-like 4 protein isoform a precursor	319	Fibrinogen C-terminal.				angiogenesis|cell differentiation|cellular lipid metabolic process|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|positive regulation of angiogenesis|response to hypoxia|signal transduction|triglyceride homeostasis	extracellular space|proteinaceous extracellular matrix	enzyme inhibitor activity|receptor binding			ovary(1)	1						CCGTCCCACCCAGCGGCCTCT	0.667		NaN											0	0	0	0.001984	0	5	25									
MUC16	94025	broad.mit.edu	37	19	9062870	9062870	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:9062870C>G	uc002mkp.2	-	3	24780	c.24576G>C	c.(24574-24576)ATG>ATC	p.M8192I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8194	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGATTCTGTCATTATGCTGG	0.483		NaN											0	0	0	0.013537	0	13	31									
DNMT1	1786	broad.mit.edu	37	19	10286275	10286275	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:10286275G>C	uc002mng.2	-	6	721	c.541C>G	c.(541-543)CAG>GAG	p.Q181E	DNMT1_uc010xlc.1_Missense_Mutation_p.Q197E|DNMT1_uc002mnh.2_Missense_Mutation_p.Q76E|DNMT1_uc010xld.1_Missense_Mutation_p.Q181E	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	181	Nuclear localization signal (Potential).|Interaction with DNMT3B.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	GACTCTTCCTGAGGTTTCCGT	0.512		NaN											0	0	0	0.007291	0	23	53									
DNMT1	1786	broad.mit.edu	37	19	10287981	10287981	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:10287981G>C	uc002mng.2	-	5	688	c.508C>G	c.(508-510)CAT>GAT	p.H170D	DNMT1_uc010xlc.1_Missense_Mutation_p.H186D|DNMT1_uc002mnh.2_Missense_Mutation_p.H65D|DNMT1_uc010xld.1_Missense_Mutation_p.H170D|DNMT1_uc010dxb.1_RNA	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	170	Interaction with PCNA.|Interaction with DNMT3B.|Interaction with the PRC2/EED-EZH2 complex (By similarity).			H->V: Abolishes interaction with PCNA.	chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	TTTGCAAAATGAGATGTGATG	0.438		NaN											0	0	0	0.006214	0	7	36									
NWD1	284434	broad.mit.edu	37	19	16860125	16860125	+	Silent	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:16860125C>G	uc002neu.3	+	6	1094	c.672C>G	c.(670-672)CTC>CTG	p.L224L	NWD1_uc002net.3_Silent_p.L89L|NWD1_uc002nev.3_Silent_p.L18L			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	224							ATP binding			skin(3)|ovary(2)|pancreas(2)	7						AGAACCTTCTCAGCAGCCTCA	0.587		NaN											0	0	0	0.013537	0	12	64									
CILP2	148113	broad.mit.edu	37	19	19654990	19654990	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:19654990G>A	uc002nmv.3	+	8	1721	c.1636G>A	c.(1636-1638)GGC>AGC	p.G546S	CILP2_uc002nmw.3_Missense_Mutation_p.G552S	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	546						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						TCGAGGTGCCGGCGTGTACCA	0.617		NaN											0	0	0	0.004672	0	3	71									
ZNF208	7757	broad.mit.edu	37	19	22155282	22155282	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:22155282T>C	uc002nqp.2	-	5	2403	c.2254A>G	c.(2254-2256)AAG>GAG	p.K752E	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TGAATTACCTTATGTTTAGTA	0.373		NaN											0	0	0	0.001168	0	3	83									
HAUS5	23354	broad.mit.edu	37	19	36108218	36108218	+	Silent	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:36108218G>T	uc002oam.1	+	8	636	c.585G>T	c.(583-585)CGG>CGT	p.R195R		NM_015302	NP_056117	O94927	HAUS5_HUMAN	HAUS augmin-like complex, subunit 5	195					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle					0						GCACCCTCCGGGCCCAGTTCC	0.632		NaN											1	0	2.64894e-19	0.01441	3.01628e-19	35	52									
HCST	10870	broad.mit.edu	37	19	36394703	36394703	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:36394703C>G	uc002ocl.1	+	3	253	c.139C>G	c.(139-141)CTG>GTG	p.L47V	HCST_uc002ock.1_Missense_Mutation_p.L47V	NM_014266	NP_055081	Q9UBK5	HCST_HUMAN	hematopoietic cell signal transducer isoform 1	47	Extracellular (Potential).				regulation of immune response	integral to membrane|plasma membrane					0	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GTCCCTCTCTCTGCCGCTCCT	0.682		NaN											0	0	0	0.00308	0	5	32									
ZNF567	163081	broad.mit.edu	37	19	37211086	37211086	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:37211086G>C	uc010xtl.1	+	6	1682	c.1460G>C	c.(1459-1461)AGA>ACA	p.R487T	ZNF567_uc002oeo.1_Missense_Mutation_p.R487T|ZNF567_uc010xtk.1_Missense_Mutation_p.R487T|ZNF567_uc002oep.3_Missense_Mutation_p.R456T|ZNF567_uc002oeq.1_Missense_Mutation_p.R456T	NM_152603	NP_689816	Q8N184	ZN567_HUMAN	zinc finger protein 567	487	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AAGGCCTTTAGAATGAAGTCA	0.418		NaN											0	0	0	0.005443	0	22	69									
SYMPK	8189	broad.mit.edu	37	19	46345718	46345718	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:46345718G>A	uc002pdn.2	-	9	1122	c.877C>T	c.(877-879)CAG>TAG	p.Q293*	SYMPK_uc002pdo.1_Nonsense_Mutation_p.Q293*|SYMPK_uc002pdp.1_Nonsense_Mutation_p.Q293*|SYMPK_uc002pdq.1_Nonsense_Mutation_p.Q293*	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	293					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		CTGCTCACCTGCGATTTGGCC	0.562		NaN											0	0	0	0.010504	0	15	80									
IRF2BP1	26145	broad.mit.edu	37	19	46387865	46387865	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:46387865C>T	uc002pds.1	-	1	1512	c.1168G>A	c.(1168-1170)GAG>AAG	p.E390K		NM_015649	NP_056464	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein	390					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		CCAGCCGCCTCGCCCTCCGGC	0.751		NaN											0	0	0	0.006214	0	9	20									
NR1H2	7376	broad.mit.edu	37	19	50881884	50881884	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:50881884C>A	uc010enw.2	+	7	857	c.581C>A	c.(580-582)TCA>TAA	p.S194*	NR1H2_uc002prv.3_RNA|NR1H2_uc002prz.3_Nonsense_Mutation_p.S193*|NR1H2_uc002psa.3_Nonsense_Mutation_p.S96*	NM_007121	NP_009052	P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	193	Poly-Ser.				negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		AGCAGCAGCTCAGCCTCTGGG	0.607		NaN											1	0	7.05477e-17	0.00499	7.86411e-17	16	17									
ZNF547	284306	broad.mit.edu	37	19	57888951	57888951	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:57888951C>G	uc002qol.2	+	4	800	c.607C>G	c.(607-609)CAG>GAG	p.Q203E	ZNF547_uc002qpm.3_Missense_Mutation_p.Q129E|ZNF547_uc010ygx.1_Missense_Mutation_p.Q203E	NM_173631	NP_775902	Q8IVP9	ZN547_HUMAN	zinc finger protein 547	203	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CAATAGACATCAGAGAACTCA	0.418		NaN											0	0	0	0.003271	0	28	39									
ZNF549	256051	broad.mit.edu	37	19	58048854	58048854	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:58048854G>A	uc002qpb.1	+	4	731	c.482G>A	c.(481-483)AGA>AAA	p.R161K	ZNF547_uc002qpm.3_Intron|ZNF549_uc010eud.1_Intron|ZNF549_uc002qpa.1_Missense_Mutation_p.R148K	NM_153263	NP_694995	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	161					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AAACACATCAGAAAGGAGGAG	0.453		NaN											0	0	0	0.00278	0	22	50									
ZNF587	84914	broad.mit.edu	37	19	58367529	58367529	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:58367529C>T	uc002qql.2	+	2	229	c.91C>T	c.(91-93)CTT>TTT	p.L31F	ZNF587_uc002qqb.2_5'UTR|ZNF587_uc010yhh.1_5'UTR|ZNF587_uc002qqi.1_5'UTR|ZNF587_uc002qqj.1_RNA|ZNF814_uc002qqk.2_Intron|ZNF587_uc010yhk.1_Missense_Mutation_p.L30F	NM_032828	NP_116217	Q96SQ5	ZN587_HUMAN	zinc finger protein 587	31	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)		GGAGTGGTGTCTTCTTAGTGA	0.512		NaN											0	0	0	0.007291	0	17	67									
MYT1L	23040	broad.mit.edu	37	2	1914104	1914104	+	Silent	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:1914104C>G	uc002qxe.2	-	13	2552	c.1725G>C	c.(1723-1725)CCG>CCC	p.P575P	MYT1L_uc002qxd.2_Silent_p.P573P|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	575	C2HC-type 3.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CTGCAGCGATCGGGCATCCGG	0.587		NaN											0	0	0	0.00333	0	22	51									
TAF1B	9014	broad.mit.edu	37	2	10008450	10008450	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:10008450G>A	uc002qzz.2	+	6	545	c.445G>A	c.(445-447)GAG>AAG	p.E149K	TAF1B_uc010exc.2_Missense_Mutation_p.E149K|TAF1B_uc002qzy.3_Missense_Mutation_p.E149K|TAF1B_uc010yja.1_5'UTR|TAF1B_uc010exd.2_5'UTR	NM_005680	NP_005671	Q53T94	TAF1B_HUMAN	TBP-associated factor 1B	149					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|breast(1)|pancreas(1)	3	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TAGTGAGCCTGAGCTGCTAAG	0.398		NaN											0	0	0	0.005443	0	19	48									
GREB1	9687	broad.mit.edu	37	2	11728988	11728988	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:11728988G>A	uc002rbk.1	+	10	1576	c.1276G>A	c.(1276-1278)GCC>ACC	p.A426T	GREB1_uc002rbn.1_Missense_Mutation_p.A426T|GREB1_uc002rbo.1_Missense_Mutation_p.A60T	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	426						integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		GCAGTACGGCGCCTCTGCCAT	0.597		NaN											0	0	0	0.01441	0	57	111									
KIF3C	3797	broad.mit.edu	37	2	26204353	26204353	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:26204353T>C	uc002rgu.2	-	1	1091	c.434A>G	c.(433-435)TAT>TGT	p.Y145C	KIF3C_uc010eyj.1_RNA|KIF3C_uc010ykr.1_Missense_Mutation_p.Y145C	NM_002254	NP_002245	O14782	KIF3C_HUMAN	kinesin family member 3C	145	Kinesin-motor.				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GATCTCCAAATAGGAGGCCCG	0.582		NaN											0	0	0	0.004289	0	31	71									
KIF3C	3797	broad.mit.edu	37	2	26204403	26204403	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:26204403G>T	uc002rgu.2	-	1	1041	c.384C>A	c.(382-384)TTC>TTA	p.F128L	KIF3C_uc010eyj.1_RNA|KIF3C_uc010ykr.1_Missense_Mutation_p.F128L	NM_002254	NP_002245	O14782	KIF3C_HUMAN	kinesin family member 3C	128	Kinesin-motor.				blood coagulation|microtubule-based movement	cytosol|kinesin complex|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGATGTGGGTGAAGATGTGCT	0.602		NaN											1	0	4.75821e-42	0.01441	5.58157e-42	44	91									
NLRC4	58484	broad.mit.edu	37	2	32461380	32461380	+	Silent	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:32461380C>A	uc002roi.2	-	7	2796	c.2550G>T	c.(2548-2550)CTG>CTT	p.L850L	NLRC4_uc002roj.1_Silent_p.L850L|NLRC4_uc010ezt.1_Silent_p.L185L	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	850	LRR 9.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					CAAGAATGCTCAGTTTGACCA	0.303		NaN											1	0	7.87624e-14	0.00278	8.5829e-14	20	40									
PLEKHH2	130271	broad.mit.edu	37	2	43919692	43919692	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:43919692C>T	uc010yny.1	+	4	309	c.226C>T	c.(226-228)CAA>TAA	p.Q76*	PLEKHH2_uc002rte.3_Nonsense_Mutation_p.Q76*|PLEKHH2_uc002rtf.3_Nonsense_Mutation_p.Q76*	NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	76	Potential.					cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AGCTAATATTCAAACCAGTGA	0.308		NaN											0	0	0	0.012319	0	18	109									
SRBD1	55133	broad.mit.edu	37	2	45801777	45801777	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:45801777G>A	uc002rus.2	-	8	1234	c.1158C>T	c.(1156-1158)TTC>TTT	p.F386F		NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	386					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			AGTTCCGAATGAAGTCAAGCG	0.388		NaN											0	0	0	0.01441	0	40	82									
PSME4	23198	broad.mit.edu	37	2	54122166	54122166	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:54122166C>T	uc002rxp.2	-	34	3946	c.3890G>A	c.(3889-3891)AGA>AAA	p.R1297K	PSME4_uc010yop.1_Missense_Mutation_p.R1183K|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_Missense_Mutation_p.R672K|PSME4_uc010fbv.1_Missense_Mutation_p.R441K	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	1297					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			CTCCCTGCTTCTGCCAAGCTT	0.388		NaN											0	0	0	0.01441	0	45	127									
CCDC88A	55704	broad.mit.edu	37	2	55615938	55615938	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:55615938C>T	uc002ryv.2	-	3	1091	c.249G>A	c.(247-249)GTG>GTA	p.V83V	CCDC88A_uc010yoz.1_Silent_p.V83V|CCDC88A_uc010ypa.1_Silent_p.V83V	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	83					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						TTATCTGTCTCACCAAAATGG	0.264		NaN											0	0	0	0.003271	0	30	70									
UGP2	7360	broad.mit.edu	37	2	64083559	64083559	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:64083559G>C	uc002scm.2	+	2	445	c.139G>C	c.(139-141)GAA>CAA	p.E47Q	UGP2_uc002scl.2_Missense_Mutation_p.E36Q|UGP2_uc010ypx.1_Missense_Mutation_p.E56Q	NM_006759	NP_006750	Q16851	UGPA_HUMAN	UDP-glucose pyrophosphorylase 2 isoform a	47					glycogen biosynthetic process|phosphorylation|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	metal ion binding|protein binding|UTP:glucose-1-phosphate uridylyltransferase activity				0						ATCATCACATGAATTTGAGGT	0.458		NaN											0	0	0	0.013114	0	34	217									
MEIS1	4211	broad.mit.edu	37	2	66795861	66795861	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:66795861C>T	uc002sdu.2	+	11	1544	c.1087C>T	c.(1087-1089)CAG>TAG	p.Q363*	MEIS1_uc002sdt.2_Nonsense_Mutation_p.Q363*|MEIS1_uc002sdv.2_Nonsense_Mutation_p.Q361*|MEIS1_uc010yqh.1_RNA|MEIS1_uc010yqi.1_Nonsense_Mutation_p.Q298*|MEIS1_uc002sdw.1_Nonsense_Mutation_p.Q219*	NM_002398	NP_002389	O00470	MEIS1_HUMAN	Meis homeobox 1	363	Required for transcriptional activation (By similarity).						sequence-specific DNA binding transcription factor activity				0						AATGGACGGTCAGCAACATAT	0.408		NaN											0	0	0	0.01441	0	98	255									
ASPRV1	151516	broad.mit.edu	37	2	70188237	70188237	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:70188237C>T	uc002sfz.3	-	1	1161	c.584G>A	c.(583-585)GGC>GAC	p.G195D		NM_152792	NP_690005	Q53RT3	APRV1_HUMAN	aspartic peptidase, retroviral-like 1 precursor	195	Extracellular (Potential).				protein maturation by peptide bond cleavage|skin development		aspartic-type endopeptidase activity			ovary(1)	1						GAGATAGTAGCCCTTACCCAT	0.602		NaN											0	0	0	0.003755	0	26	48									
ASPRV1	151516	broad.mit.edu	37	2	70188460	70188460	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:70188460C>G	uc002sfz.3	-	1	938	c.361G>C	c.(361-363)GAA>CAA	p.E121Q		NM_152792	NP_690005	Q53RT3	APRV1_HUMAN	aspartic peptidase, retroviral-like 1 precursor	121	Extracellular (Potential).				protein maturation by peptide bond cleavage|skin development		aspartic-type endopeptidase activity			ovary(1)	1						TTGATGACTTCAAAGCTGTGC	0.562		NaN											0	0	0	0.003163	0	13	54									
ASPRV1	151516	broad.mit.edu	37	2	70188511	70188511	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:70188511C>G	uc002sfz.3	-	1	887	c.310G>C	c.(310-312)GAA>CAA	p.E104Q		NM_152792	NP_690005	Q53RT3	APRV1_HUMAN	aspartic peptidase, retroviral-like 1 precursor	104	Extracellular (Potential).				protein maturation by peptide bond cleavage|skin development		aspartic-type endopeptidase activity			ovary(1)	1						TCAAAAGGTTCCGGGACGAAG	0.582		NaN											0	0	0	0.003954	0	22	66									
ATP6V1B1	525	broad.mit.edu	37	2	71188791	71188791	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:71188791C>T	uc002shj.2	+	8	840	c.753C>T	c.(751-753)GTC>GTT	p.V251V	ATP6V1B1_uc002shi.1_Silent_p.V251V|ATP6V1B1_uc010fdv.2_Silent_p.V251V|ATP6V1B1_uc010fdw.2_RNA|ATP6V1B1_uc010fdx.2_Silent_p.V209V	NM_001692	NP_001683	P15313	VATB1_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1	251					ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			skin(1)	1						TGGGGAACGTCTGCCTCTTCC	0.567		NaN											0	0	0	0.007835	0	32	64									
CAPG	822	broad.mit.edu	37	2	85622017	85622017	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:85622017C>T	uc002spl.1	-	10	1296	c.1046G>A	c.(1045-1047)TGA>TAA	p.*349*	CAPG_uc002spm.1_Silent_p.*334*|CAPG_uc010ysq.1_Silent_p.*349*|CAPG_uc010fgi.1_Silent_p.*349*	NM_001747	NP_001738	P40121	CAPG_HUMAN	gelsolin-like capping protein	349					barbed-end actin filament capping|protein complex assembly	F-actin capping protein complex|melanosome|nuclear membrane|nucleolus	actin binding				0						CGCCCACCCTCATTTCCAGTC	0.592		NaN											0	0	0	0.012319	0	17	48									
CAPG	822	broad.mit.edu	37	2	85622055	85622055	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:85622055C>A	uc002spl.1	-	10	1258	c.1008G>T	c.(1006-1008)GAG>GAT	p.E336D	CAPG_uc002spm.1_Missense_Mutation_p.E321D|CAPG_uc010ysq.1_Missense_Mutation_p.E336D|CAPG_uc010fgi.1_Missense_Mutation_p.E336D	NM_001747	NP_001738	P40121	CAPG_HUMAN	gelsolin-like capping protein	336					barbed-end actin filament capping|protein complex assembly	F-actin capping protein complex|melanosome|nuclear membrane|nucleolus	actin binding				0						AGATGGGACTCTCATGGCCCT	0.597		NaN											1	0	0.000132079	0.008871	0.000136528	14	46									
CAPG	822	broad.mit.edu	37	2	85625194	85625194	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:85625194C>T	uc002spl.1	-	8	1091	c.841G>A	c.(841-843)GAC>AAC	p.D281N	CAPG_uc002spm.1_Missense_Mutation_p.D266N|CAPG_uc010ysq.1_Missense_Mutation_p.D281N|CAPG_uc010fgi.1_Missense_Mutation_p.D281N|CAPG_uc010fgj.1_Missense_Mutation_p.D175N	NM_001747	NP_001738	P40121	CAPG_HUMAN	gelsolin-like capping protein	281	Gelsolin-like 3.				barbed-end actin filament capping|protein complex assembly	F-actin capping protein complex|melanosome|nuclear membrane|nucleolus	actin binding				0						ACAAAGCAGTCATCAGATATC	0.547		NaN											0	0	0	0.01441	0	23	129									
CAPG	822	broad.mit.edu	37	2	85625197	85625197	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:85625197C>T	uc002spl.1	-	8	1088	c.838G>A	c.(838-840)GAT>AAT	p.D280N	CAPG_uc002spm.1_Missense_Mutation_p.D265N|CAPG_uc010ysq.1_Missense_Mutation_p.D280N|CAPG_uc010fgi.1_Missense_Mutation_p.D280N|CAPG_uc010fgj.1_Missense_Mutation_p.D174N	NM_001747	NP_001738	P40121	CAPG_HUMAN	gelsolin-like capping protein	280	Gelsolin-like 3.				barbed-end actin filament capping|protein complex assembly	F-actin capping protein complex|melanosome|nuclear membrane|nucleolus	actin binding				0						AAGCAGTCATCAGATATCAGC	0.547		NaN											0	0	0	0.01441	0	19	133									
CAPG	822	broad.mit.edu	37	2	85625233	85625233	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:85625233C>T	uc002spl.1	-	8	1052	c.802G>A	c.(802-804)GAC>AAC	p.D268N	CAPG_uc002spm.1_Missense_Mutation_p.D253N|CAPG_uc010ysq.1_Missense_Mutation_p.D268N|CAPG_uc010fgi.1_Missense_Mutation_p.D268N|CAPG_uc010fgj.1_Missense_Mutation_p.D162N	NM_001747	NP_001738	P40121	CAPG_HUMAN	gelsolin-like capping protein	268	Gelsolin-like 3.				barbed-end actin filament capping|protein complex assembly	F-actin capping protein complex|melanosome|nuclear membrane|nucleolus	actin binding				0						GGGCTGGAGTCAGCCACCTTG	0.567		NaN											0	0	0	0.01441	0	22	101									
CD8A	925	broad.mit.edu	37	2	87017470	87017470	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:87017470G>T	uc002srt.2	-	2	1273	c.384C>A	c.(382-384)TTC>TTA	p.F128L	RMND5A_uc002srs.3_Intron|CD8A_uc002srv.2_Missense_Mutation_p.F128L|CD8A_uc010ytn.1_Missense_Mutation_p.F169L|CD8A_uc002sru.2_Missense_Mutation_p.F128L	NM_001768	NP_001759	P01732	CD8A_HUMAN	CD8 antigen alpha polypeptide isoform 1	128	Ig-like V-type.|Extracellular (Potential).				antigen processing and presentation|regulation of immune response|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			ovary(1)	1						AGACCGGCACGAAGTGGCTGA	0.627		NaN											1	0	3.99451e-17	0.009535	4.46986e-17	26	59									
TMEM131	23505	broad.mit.edu	37	2	98409038	98409038	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:98409038C>T	uc002syh.3	-	31	4184	c.3955G>A	c.(3955-3957)GAA>AAA	p.E1319K		NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	1319	Pro-rich.					integral to membrane				ovary(4)|central_nervous_system(2)	6						GACAGCCTTTCAGGCTGCGGC	0.677		NaN											0	0	0	0.00308	0	7	20									
EIF5B	9669	broad.mit.edu	37	2	100006265	100006265	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:100006265G>A	uc002tab.2	+	15	2540	c.2356G>A	c.(2356-2358)GAA>AAA	p.E786K		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	786					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						TACAAAAGATGAATTTGAGGA	0.353		NaN											0	0	0	0.006999	0	31	53									
EIF5B	9669	broad.mit.edu	37	2	100006708	100006708	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:100006708G>C	uc002tab.2	+	16	2614	c.2430G>C	c.(2428-2430)GAG>GAC	p.E810D		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	810					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						TGTTTTATGAGAATAAAGATC	0.428		NaN											0	0	0	0.01441	0	70	178									
EIF5B	9669	broad.mit.edu	37	2	100007070	100007070	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:100007070G>C	uc002tab.2	+	17	2834	c.2650G>C	c.(2650-2652)GAA>CAA	p.E884Q		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	884					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						GCGTTTGAAGGAAGGAGATAC	0.448		NaN											0	0	0	0.007835	0	33	105									
SLC9A2	6549	broad.mit.edu	37	2	103322367	103322367	+	Silent	SNP	A	A	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:103322367A>G	uc002tca.2	+	11	2182	c.2040A>G	c.(2038-2040)CTA>CTG	p.L680L		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	680	Cytoplasmic (Potential).					integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8						CAGAAAAGCTACAAAAGAGGA	0.303		NaN											0	0	0	0.003163	0	13	30									
ST6GAL2	84620	broad.mit.edu	37	2	107446552	107446552	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:107446552G>T	uc002tdq.2	-	5	1407	c.1288C>A	c.(1288-1290)CAA>AAA	p.Q430K	ST6GAL2_uc002tdr.2_Missense_Mutation_p.Q430K|ST6GAL2_uc002tds.3_Missense_Mutation_p.Q430K	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	430	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						GGGTTTGGTTGAATCTTCTCT	0.368		NaN											1	0	5.44703e-19	0.009718	6.17824e-19	40	126									
RANBP2	5903	broad.mit.edu	37	2	109382668	109382668	+	Silent	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:109382668C>A	uc002tem.3	+	20	5799	c.5673C>A	c.(5671-5673)ATC>ATA	p.I1891I		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	1891					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						GATTTTCCATCCCTGTGTCTG	0.378		NaN											1	0	2.27525e-19	0.003954	2.59584e-19	19	125									
RANBP2	5903	broad.mit.edu	37	2	109383783	109383783	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:109383783C>G	uc002tem.3	+	20	6914	c.6788C>G	c.(6787-6789)TCA>TGA	p.S2263*		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	2263					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						TTTGGTGAGTCAACAACAGGA	0.418		NaN											0	0	0	0.01441	0	50	297									
CLASP1	23332	broad.mit.edu	37	2	122182786	122182786	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:122182786G>A	uc002tnc.2	-	22	2531	c.2141C>T	c.(2140-2142)TCA>TTA	p.S714L	CLASP1_uc002tmz.2_5'UTR|CLASP1_uc002tna.2_5'UTR|CLASP1_uc010yyw.1_RNA|CLASP1_uc002tnb.2_RNA|CLASP1_uc010yyx.1_RNA|CLASP1_uc010yyy.1_RNA|CLASP1_uc010yyz.1_Missense_Mutation_p.S722L|CLASP1_uc010yza.1_Missense_Mutation_p.S714L|CLASP1_uc010yzb.1_RNA|CLASP1_uc010yzc.1_RNA|CLASP1_uc002tng.1_Missense_Mutation_p.S721L	NM_015282	NP_056097	Q7Z460	CLAP1_HUMAN	CLIP-associating protein 1 isoform 1	714	Ser-rich.|Interaction with microtubules, MAPRE1 and MAPRE3.				axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			ovary(1)|central_nervous_system(1)	2	Renal(3;0.0496)					TCGCTTTTCTGAAGACGGTGT	0.512		NaN											0	0	0	0.003271	0	31	68									
CSRNP3	80034	broad.mit.edu	37	2	166514277	166514277	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:166514277C>G	uc002udf.2	+	5	531	c.155C>G	c.(154-156)TCC>TGC	p.S52C	CSRNP3_uc002udg.2_Missense_Mutation_p.S52C	NM_024969	NP_079245	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	52	Ser-rich.				apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|large_intestine(1)|skin(1)	5						TCAGCTTCCTCCATTCTCAAA	0.443		NaN											0	0	0	0.00874	0	31	85									
LASS6	253782	broad.mit.edu	37	2	169313067	169313067	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:169313067G>T	uc002ueb.1	+	1	233	c.109G>T	c.(109-111)GAC>TAC	p.D37Y	LASS6_uc002uec.1_Missense_Mutation_p.D37Y	NM_203463	NP_982288	Q6ZMG9	CERS6_HUMAN	longevity assurance homolog 6	37	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			skin(1)	1						GCAGGCTGAGGACCTCTATCT	0.577		NaN											1	0	3.83957e-06	0.00278	4.00442e-06	19	59									
GAD1	2571	broad.mit.edu	37	2	171702544	171702544	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:171702544G>C	uc002ugi.2	+	10	1395	c.973G>C	c.(973-975)GAG>CAG	p.E325Q		NM_000817	NP_000808	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 isoform GAD67	325					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(1)	1					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	AGCTGATTTTGAGGCAAAAAT	0.363		NaN											0	0	0	0.005443	0	22	105									
SLC25A12	8604	broad.mit.edu	37	2	172691273	172691273	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:172691273G>C	uc002uhh.2	-	7	804	c.715C>G	c.(715-717)CTA>GTA	p.L239V	SLC25A12_uc010fqh.2_Missense_Mutation_p.L132V|SLC25A12_uc010zdv.1_RNA	NM_003705	NP_003696	O75746	CMC1_HUMAN	solute carrier family 25, member 12	239					gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)		L-Aspartic Acid(DB00128)	GTGCCAGCTAGAGTGCTATAT	0.373		NaN											0	0	0	0.011902	0	34	105									
NFE2L2	4780	broad.mit.edu	37	2	178097233	178097233	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:178097233G>C	uc002ulh.3	-	4	1036	c.481C>G	c.(481-483)CAG>GAG	p.Q161E	NFE2L2_uc002ulg.3_Missense_Mutation_p.Q145E|NFE2L2_uc010zfa.1_Missense_Mutation_p.Q138E|NFE2L2_uc002uli.3_Missense_Mutation_p.Q145E|NFE2L2_uc010fra.2_3'UTR	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	161					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			GACTGAGCCTGATTAGTAGCA	0.448		NaN	Mis		NSCLC|HNSCC					HNSCC(56;0.16)			0	0	0	0.006214	0	9	56									
ITGA4	3676	broad.mit.edu	37	2	182363467	182363467	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:182363467G>C	uc002unu.2	+	15	2421	c.1658G>C	c.(1657-1659)AGA>ACA	p.R553T	ITGA4_uc010frj.1_Missense_Mutation_p.R35T	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	553	Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	GTGTCCAGCAGAGAAGCTAAC	0.383		NaN											0	0	0	0.00278	0	18	79									
MSTN	2660	broad.mit.edu	37	2	190924966	190924966	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:190924966C>T	uc002urp.2	-	2	702	c.569G>A	c.(568-570)CGA>CAA	p.R190Q		NM_005259	NP_005250	O14793	GDF8_HUMAN	myostatin precursor	190					muscle organ development|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000742)|Epithelial(96;0.0121)|all cancers(119;0.0395)			TTTCAGAGATCGGATTCCAGT	0.428		NaN											0	0	0	0.01441	0	43	239									
MSTN	2660	broad.mit.edu	37	2	190925004	190925004	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:190925004G>C	uc002urp.2	-	2	664	c.531C>G	c.(529-531)ATC>ATG	p.I177M		NM_005259	NP_005250	O14793	GDF8_HUMAN	myostatin precursor	177					muscle organ development|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000742)|Epithelial(96;0.0121)|all cancers(119;0.0395)			TCATAGGTTTGATGAGTCTCA	0.413		NaN											0	0	0	0.013537	0	11	228									
MSTN	2660	broad.mit.edu	37	2	190926953	190926953	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:190926953C>G	uc002urp.2	-	1	503	c.370G>C	c.(370-372)GAG>CAG	p.E124Q		NM_005259	NP_005250	O14793	GDF8_HUMAN	myostatin precursor	124					muscle organ development|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000742)|Epithelial(96;0.0121)|all cancers(119;0.0395)			TACTTACACTCTGTAGGCATG	0.403		NaN											0	0	0	0.01441	0	44	218									
MSTN	2660	broad.mit.edu	37	2	190927191	190927191	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:190927191C>A	uc002urp.2	-	1	265	c.132G>T	c.(130-132)TGG>TGT	p.W44C		NM_005259	NP_005250	O14793	GDF8_HUMAN	myostatin precursor	44					muscle organ development|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000742)|Epithelial(96;0.0121)|all cancers(119;0.0395)			TGTTTTGTCTCCAAGTACATG	0.378		NaN											1	0	5.71845e-15	0.005524	6.3261e-15	29	202									
EEF1B2	1933	broad.mit.edu	37	2	207025358	207025358	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:207025358A>G	uc002vbf.1	+	3	285	c.127A>G	c.(127-129)AGC>GGC	p.S43G	NDUFS1_uc010ziq.1_5'Flank|NDUFS1_uc002vbe.2_5'Flank|NDUFS1_uc010zir.1_5'Flank|NDUFS1_uc010zis.1_5'Flank|NDUFS1_uc010zit.1_5'Flank|NDUFS1_uc010ziu.1_5'Flank|EEF1B2_uc002vbg.1_Missense_Mutation_p.S43G|EEF1B2_uc002vbh.1_Missense_Mutation_p.S43G|SNORD51_uc002vbi.1_5'Flank|SNORA41_uc002vbj.2_5'Flank	NM_001037663	NP_001032752	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta	43	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity				0						AGCCGTGTCCAGCCCACCGCC	0.468		NaN											0	0	0	0.000602	0	5	248									
ATIC	471	broad.mit.edu	37	2	216177324	216177324	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:216177324C>T	uc002vex.3	+	2	297	c.123C>T	c.(121-123)CTC>CTT	p.L41L	ATIC_uc010zjo.1_5'UTR|ATIC_uc002vey.3_Silent_p.L40L	NM_004044	NP_004035	P31939	PUR9_HUMAN	5-aminoimidazole-4-carboxamide ribonucleotide	41					IMP biosynthetic process|purine base metabolic process	cytosol	IMP cyclohydrolase activity|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|protein homodimerization activity		ATIC/ALK(24)	haematopoietic_and_lymphoid_tissue(22)|ovary(2)|lung(2)|soft_tissue(2)|skin(1)	29		Renal(323;0.229)		Epithelial(149;2.02e-06)|all cancers(144;0.000316)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.0097)	Tetrahydrofolic acid(DB00116)	CAAAAGCTCTCAGGGATGCTG	0.428		NaN	T	ALK	ALCL								0	0	0	0.00333	0	22	38									
SLC23A3	151295	broad.mit.edu	37	2	220033453	220033453	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:220033453G>A	uc010zks.1	-	5	706	c.595C>T	c.(595-597)CCC>TCC	p.P199S	NHEJ1_uc002vjq.3_RNA|SLC23A3_uc010zkr.1_Missense_Mutation_p.P207S|SLC23A3_uc010fwb.2_Missense_Mutation_p.P199S|SLC23A3_uc002vjs.1_Missense_Mutation_p.S51F|SLC23A3_uc002vjt.1_Missense_Mutation_p.P57S	NM_001144889	NP_001138361	Q6PIS1	S23A3_HUMAN	solute carrier family 23 (nucleobase	199	Helical; (Potential).				transmembrane transport	integral to membrane	protein binding|transporter activity				0		Renal(207;0.0474)		Epithelial(149;9.27e-07)|all cancers(144;0.000156)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACCAGGCTGGGAGCCAGCACC	0.662		NaN											0	0	0	0.000602	0	4	15									
SLC23A3	151295	broad.mit.edu	37	2	220034633	220034634	+	Nonsense_Mutation	DNP	GG	GG	TA			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:220034633_220034634GG>TA	uc010zks.1	-	1	184_185	c.73_74CC>TA	c.(73-75)CCA>TAA	p.P25*	NHEJ1_uc002vjq.3_RNA|SLC23A3_uc010zkr.1_Nonsense_Mutation_p.P25*|SLC23A3_uc010fwb.2_Nonsense_Mutation_p.P25*|SLC23A3_uc002vjs.1_5'Flank|SLC23A3_uc002vjt.1_5'Flank	NM_001144889	NP_001138361	Q6PIS1	S23A3_HUMAN	solute carrier family 23 (nucleobase	25	Cytoplasmic (Potential).				transmembrane transport	integral to membrane	protein binding|transporter activity				0		Renal(207;0.0474)		Epithelial(149;9.27e-07)|all cancers(144;0.000156)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGAGCAGGTGGAGGCAAGGGG	0.614		NaN											0	0	0	0.004672	0	4	35									
TRIP12	9320	broad.mit.edu	37	2	230636274	230636274	+	Silent	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:230636274G>C	uc002vpw.1	-	38	5653	c.5544C>G	c.(5542-5544)GTC>GTG	p.V1848V	TRIP12_uc002vpx.1_Silent_p.V1896V|TRIP12_uc002vpy.1_Silent_p.V1578V	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1848					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		TGAGTGGGAAGACTGATTCAA	0.378		NaN											0	0	0	0.001168	0	5	47									
INPP5D	3635	broad.mit.edu	37	2	234079180	234079180	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr2:234079180G>A	uc010zmo.1	+	15	1983	c.1830G>A	c.(1828-1830)CAG>CAA	p.Q610Q	INPP5D_uc010zmp.1_Silent_p.Q609Q	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	610					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		AGCAGCAGCAGTACGCAGACC	0.532		NaN											0	0	0	0.00278	0	18	36									
TRIB3	57761	broad.mit.edu	37	20	376874	376874	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:376874C>T	uc002wdm.2	+	4	1123	c.617C>T	c.(616-618)TCC>TTC	p.S206F	TRIB3_uc002wdn.2_Missense_Mutation_p.S233F	NM_021158	NP_066981	Q96RU7	TRIB3_HUMAN	tribbles 3	206	Protein kinase.				apoptosis|cellular lipid metabolic process|insulin receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein binding|positive regulation of ubiquitin-protein ligase activity|regulation of glucose transport|regulation of MAP kinase activity|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	ATP binding|protein kinase activity|protein kinase binding|protein kinase inhibitor activity|transcription corepressor activity|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			central_nervous_system(2)	2		all_epithelial(17;0.165)|Lung NSC(37;0.191)|Breast(17;0.231)		Colorectal(46;0.101)|COAD - Colon adenocarcinoma(99;0.112)		CTGGAGGACTCCTGCGTGCTG	0.607		NaN											0	0	0	0.00245	0	12	57									
RIN2	54453	broad.mit.edu	37	20	19977329	19977329	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:19977329A>G	uc002wro.1	+	10	2243	c.2207A>G	c.(2206-2208)TAT>TGT	p.Y736C	RIN2_uc010gcu.1_Missense_Mutation_p.Y303C|RIN2_uc010gcv.1_Missense_Mutation_p.Y530C	NM_018993	NP_061866	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	736	VPS9.				endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			lung(4)|ovary(1)	5						TCAGGAGGCTATTACTTGACA	0.498		NaN											0	0	0	0.004007	0	15	44									
KIF3B	9371	broad.mit.edu	37	20	30897849	30897849	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:30897849G>A	uc002wxq.2	+	2	436	c.269G>A	c.(268-270)GGA>GAA	p.G90E	KIF3B_uc010ztv.1_Missense_Mutation_p.G90E|KIF3B_uc010ztw.1_Missense_Mutation_p.G90E	NM_004798	NP_004789	O15066	KIF3B_HUMAN	kinesin family member 3B	90	Kinesin-motor.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			central_nervous_system(3)|ovary(2)	5			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GGTTTCAATGGAACCATTTTT	0.453		NaN											0	0	0	0.009718	0	35	78									
C20orf70	140683	broad.mit.edu	37	20	31767433	31767433	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:31767433C>A	uc002wyo.1	+	7	740	c.669C>A	c.(667-669)TTC>TTA	p.F223L		NM_080574	NP_542141	Q96DR5	SPLC2_HUMAN	chromosome 20 open reading frame 70 precursor	223						extracellular region	lipid binding			ovary(1)|central_nervous_system(1)	2						TCCGCATCTTCATCCACTCCC	0.527		NaN											1	0	5.02048e-33	0.01441	5.86561e-33	60	147									
CBFA2T2	9139	broad.mit.edu	37	20	32217653	32217653	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:32217653G>A	uc002wzg.1	+	9	1725	c.1188G>A	c.(1186-1188)CTG>CTA	p.L396L	CBFA2T2_uc010zug.1_Silent_p.L170L|CBFA2T2_uc002wze.1_Silent_p.L387L|CBFA2T2_uc002wzf.1_RNA|CBFA2T2_uc002wzh.1_Silent_p.L367L|CBFA2T2_uc002wzi.1_RNA|CBFA2T2_uc002wzj.1_RNA	NM_005093	NP_005084	O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit	396						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)|skin(1)	2						ACACAGAGCTGAGGAAAACGG	0.507		NaN											0	0	0	0.001168	0	5	34									
SLC2A10	81031	broad.mit.edu	37	20	45354826	45354826	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:45354826C>T	uc002xsl.2	+	2	1248	c.1151C>T	c.(1150-1152)TCA>TTA	p.S384L		NM_030777	NP_110404	O95528	GTR10_HUMAN	solute carrier family 2 member 10	384	Extracellular (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				GGAGACCCCTCAGCCCCTCCT	0.632		NaN											0	0	0	0.00245	0	12	57									
TAF4	6874	broad.mit.edu	37	20	60575694	60575694	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:60575694G>A	uc002ybs.2	-	10	2570	c.2570C>T	c.(2569-2571)TCT>TTT	p.S857F		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	857					interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			CACCAATTCAGAGTTCGTGGC	0.443		NaN											0	0	0	0.010771	0	40	52									
LAMA5	3911	broad.mit.edu	37	20	60900379	60900379	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:60900379G>T	uc002ycq.2	-	41	5589	c.5522C>A	c.(5521-5523)TCA>TAA	p.S1841*		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	1841	Laminin EGF-like 16; second part.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CACCTGGCATGAGTCCCCCCG	0.677		NaN											1	0	0.000978159	0.010729	0.00100754	9	15									
DIDO1	11083	broad.mit.edu	37	20	61541311	61541311	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:61541311C>T	uc002ydr.1	-	4	1165	c.901G>A	c.(901-903)GAG>AAG	p.E301K	DIDO1_uc002yds.1_Missense_Mutation_p.E301K|DIDO1_uc002ydt.1_Missense_Mutation_p.E301K|DIDO1_uc002ydu.1_Missense_Mutation_p.E301K|DIDO1_uc002ydv.1_Missense_Mutation_p.E301K|DIDO1_uc002ydw.1_Missense_Mutation_p.E301K|DIDO1_uc002ydx.1_Missense_Mutation_p.E301K|DIDO1_uc011aao.1_Missense_Mutation_p.E301K	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	301	PHD-type.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CCTCGAGCCTCAGAAATGCCC	0.453		NaN											0	0	0	0.010818	0	25	63									
ARFGAP1	55738	broad.mit.edu	37	20	61907473	61907473	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:61907473C>G	uc002yem.2	+	3	203	c.91C>G	c.(91-93)CAG>GAG	p.Q31E	ARFGAP1_uc011aas.1_Intron|ARFGAP1_uc011aat.1_5'UTR|ARFGAP1_uc002yel.2_Missense_Mutation_p.Q31E|ARFGAP1_uc002yen.2_Missense_Mutation_p.Q31E	NM_018209	NP_060679	Q8N6T3	ARFG1_HUMAN	ADP-ribosylation factor GTPase activating	31	C4-type.|Arf-GAP.				COPI coating of Golgi vesicle|protein transport|regulation of ARF GTPase activity|retrograde vesicle-mediated transport, Golgi to ER	cytosol|Golgi-associated vesicle membrane	ARF GTPase activator activity|zinc ion binding			pancreas(1)	1	all_cancers(38;1.59e-09)					GTTCAATCCTCAGTGGGTCAG	0.617		NaN											0	0	0	0.01441	0	85	154									
COL20A1	57642	broad.mit.edu	37	20	61936830	61936830	+	Silent	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr20:61936830G>C	uc011aau.1	+	4	355	c.255G>C	c.(253-255)CTG>CTC	p.L85L	COL20A1_uc011aav.1_5'Flank	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	85	Fibronectin type-III 1.				cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					TGGGGGGCCTGAGCCCCTCCA	0.612		NaN											0	0	0	0.010729	0	8	11									
N6AMT1	29104	broad.mit.edu	37	21	30255367	30255367	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:30255367G>A	uc002ymo.1	-	2	187	c.161C>T	c.(160-162)TCA>TTA	p.S54L	N6AMT1_uc002ymp.1_Missense_Mutation_p.S54L|N6AMT1_uc002ymq.1_RNA	NM_013240	NP_037372	Q9Y5N5	HEMK2_HUMAN	N-6 adenine-specific DNA methyltransferase 1	54	S-adenosyl-L-methionine binding (By similarity).				positive regulation of cell growth	protein complex	nucleic acid binding|protein binding|protein methyltransferase activity				0						ACCAGACCCTGACCCTACTTC	0.368		NaN											0	0	0	0.004007	0	11	52									
SOD1	6647	broad.mit.edu	37	21	33036175	33036175	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:33036175C>G	uc002ypa.2	+	2	293	c.145C>G	c.(145-147)CAT>GAT	p.H49D	SOD1_uc002ypb.2_Missense_Mutation_p.H30D|SOD1_uc002ypc.2_RNA	NM_000454	NP_000445	P00441	SODC_HUMAN	superoxide dismutase 1, soluble	49		Copper; catalytic.	H -> Q (in ALS1).|H -> R (in ALS1).		activation of MAPK activity|auditory receptor cell stereocilium organization|cell aging|cellular iron ion homeostasis|DNA fragmentation involved in apoptotic nuclear change|double-strand break repair|embryo implantation|glutathione metabolic process|heart contraction|hydrogen peroxide biosynthetic process|locomotory behavior|muscle cell homeostasis|myeloid cell homeostasis|negative regulation of cholesterol biosynthetic process|negative regulation of neuron apoptosis|neurofilament cytoskeleton organization|ovarian follicle development|peripheral nervous system myelin maintenance|placenta development|platelet activation|platelet degranulation|positive regulation of cytokine production|regulation of blood pressure|regulation of mitochondrial membrane potential|regulation of multicellular organism growth|regulation of organ growth|regulation of T cell differentiation in thymus|relaxation of vascular smooth muscle|removal of superoxide radicals|response to axon injury|response to drug|response to ethanol|response to heat|response to hydrogen peroxide|retina homeostasis|sensory perception of sound|spermatogenesis|thymus development	cytoplasmic vesicle|cytosol|dendrite cytoplasm|extracellular matrix|extracellular space|mitochondrial matrix|neuronal cell body|nucleus|peroxisome|protein complex	chaperone binding|copper ion binding|protein homodimerization activity|protein phosphatase 2B binding|superoxide dismutase activity|zinc ion binding				0						ATTCCATGTTCATGAGTTTGG	0.448		NaN											0	0	0	0.01441	0	37	140									
SOD1	6647	broad.mit.edu	37	21	33039670	33039670	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:33039670C>T	uc002ypa.2	+	4	487	c.339C>T	c.(337-339)ATC>ATT	p.I113I	SOD1_uc002ypb.2_Silent_p.I94I|SOD1_uc002ypc.2_RNA	NM_000454	NP_000445	P00441	SODC_HUMAN	superoxide dismutase 1, soluble	113			I -> M (in ALS1).|I -> T (in ALS1).		activation of MAPK activity|auditory receptor cell stereocilium organization|cell aging|cellular iron ion homeostasis|DNA fragmentation involved in apoptotic nuclear change|double-strand break repair|embryo implantation|glutathione metabolic process|heart contraction|hydrogen peroxide biosynthetic process|locomotory behavior|muscle cell homeostasis|myeloid cell homeostasis|negative regulation of cholesterol biosynthetic process|negative regulation of neuron apoptosis|neurofilament cytoskeleton organization|ovarian follicle development|peripheral nervous system myelin maintenance|placenta development|platelet activation|platelet degranulation|positive regulation of cytokine production|regulation of blood pressure|regulation of mitochondrial membrane potential|regulation of multicellular organism growth|regulation of organ growth|regulation of T cell differentiation in thymus|relaxation of vascular smooth muscle|removal of superoxide radicals|response to axon injury|response to drug|response to ethanol|response to heat|response to hydrogen peroxide|retina homeostasis|sensory perception of sound|spermatogenesis|thymus development	cytoplasmic vesicle|cytosol|dendrite cytoplasm|extracellular matrix|extracellular space|mitochondrial matrix|neuronal cell body|nucleus|peroxisome|protein complex	chaperone binding|copper ion binding|protein homodimerization activity|protein phosphatase 2B binding|superoxide dismutase activity|zinc ion binding				0						ACCATTGCATCATTGGCCGCA	0.428		NaN											0	0	0	0.007291	0	21	165									
SON	6651	broad.mit.edu	37	21	34927106	34927106	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:34927106C>T	uc002yse.1	+	3	5618	c.5569C>T	c.(5569-5571)CAT>TAT	p.H1857Y	SON_uc002ysb.1_Missense_Mutation_p.H1857Y|SON_uc002ysc.2_Missense_Mutation_p.H1857Y|SON_uc002ysd.2_Missense_Mutation_p.H848Y|SON_uc002ysf.1_Intron|SON_uc002ysg.2_Missense_Mutation_p.H848Y	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	1857					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						GTCCAAGTCTCATCGCTCTCA	0.448		NaN											0	0	0	0.005443	0	22	77									
DOPEY2	9980	broad.mit.edu	37	21	37603182	37603182	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:37603182C>G	uc002yvg.2	+	14	2179	c.2100C>G	c.(2098-2100)TTC>TTG	p.F700L	DOPEY2_uc011aeb.1_Missense_Mutation_p.F700L	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	700					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						CAGACTTGTTCACAGCACGAG	0.542		NaN											0	0	0	0.004482	0	8	81									
HLCS	3141	broad.mit.edu	37	21	38126702	38126702	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:38126702G>C	uc010gnb.2	-	11	3227	c.2026C>G	c.(2026-2028)CTG>GTG	p.L676V	HLCS_uc002yvs.2_Missense_Mutation_p.L676V	NM_000411	NP_000402	P50747	BPL1_HUMAN	holocarboxylase synthetase	676					cell proliferation|histone biotinylation|response to biotin	chromatin|cytosol|mitochondrion|nuclear lamina|nuclear matrix	ATP binding|biotin binding|biotin-[acetyl-CoA-carboxylase] ligase activity|biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity|biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity|enzyme binding			ovary(2)|breast(1)|kidney(1)|liver(1)	5		Myeloproliferative disorder(46;0.0422)			Biotin(DB00121)	GCGCTGCCCAGATGGACTTGC	0.557		NaN											0	0	0	0.006122	0	12	41									
TTC3	7267	broad.mit.edu	37	21	38463619	38463619	+	Silent	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:38463619G>C	uc002yvz.2	+	7	612	c.507G>C	c.(505-507)CTG>CTC	p.L169L	TTC3_uc011aee.1_Intron|TTC3_uc002ywa.2_Silent_p.L169L|TTC3_uc002ywb.2_Silent_p.L169L|TTC3_uc010gnf.2_5'UTR|TTC3_uc011aed.1_Intron|TTC3_uc010gne.1_Silent_p.L169L	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	169					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				AAGAAGCTCTGAATTGGATAA	0.308		NaN											0	0	0	0.00245	0	11	68									
BRWD1	54014	broad.mit.edu	37	21	40627734	40627734	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:40627734C>G	uc002yxk.1	-	19	2231	c.2092G>C	c.(2092-2094)GAC>CAC	p.D698H	BRWD1_uc010goc.1_5'UTR|BRWD1_uc002yxl.2_Missense_Mutation_p.D698H|BRWD1_uc010goe.1_RNA|BRWD1_uc010gof.1_Missense_Mutation_p.D151H|BRWD1_uc010gog.1_RNA|BRWD1_uc010goh.1_Intron|BRWD1_uc010goi.1_Missense_Mutation_p.D418H	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	698					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				GACTGAATGTCTAAGCTCAGC	0.418		NaN											0	0	0	0.003163	0	14	65									
C21orf29	54084	broad.mit.edu	37	21	45948429	45948429	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:45948429C>T	uc002zfe.1	-	6	894	c.828G>A	c.(826-828)CCG>CCA	p.P276P	C21orf29_uc010gpv.1_Silent_p.P208P	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	276					cell adhesion	extracellular region	structural molecule activity				0						CCTCGGTACACGGTGGCTGGG	0.577		NaN											0	0	0	0.005443	0	27	25									
KRTAP12-4	386684	broad.mit.edu	37	21	46074247	46074247	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr21:46074247G>C	uc002zfs.1	-	1	330	c.285C>G	c.(283-285)TTC>TTG	p.F95L	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198698	NP_941971	P60329	KR124_HUMAN	keratin associated protein 12-4	95	15 X 5 AA approximate repeats.|14.					keratin filament				ovary(1)	1						GGGTGGGGCAGAAGGGCTGGC	0.632		NaN											0	0	0	0.001168	0	6	31									
GNB1L	54584	broad.mit.edu	37	22	19808787	19808787	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr22:19808787C>G	uc002zqe.1	-	2	486	c.92G>C	c.(91-93)GGA>GCA	p.G31A	GNB1L_uc002zqd.1_Intron|GNB1L_uc002zqf.1_Missense_Mutation_p.G31A	NM_053004	NP_443730	Q9BYB4	GNB1L_HUMAN	guanine nucleotide binding protein	31	WD 1.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	internal side of plasma membrane|intracellular				breast(1)	1	Colorectal(54;0.0993)					AGCCTGGGCTCCTTCGCAGAA	0.687		NaN											0	0	0	0.008871	0	18	71									
SMARCB1	6598	broad.mit.edu	37	22	24175882	24175882	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr22:24175882G>T	uc002zyb.2	+	8	1317	c.1110G>T	c.(1108-1110)AGG>AGT	p.R370S	SMARCB1_uc002zya.2_Intron|SMARCB1_uc002zyc.2_Missense_Mutation_p.R361S|SMARCB1_uc002zyd.2_Missense_Mutation_p.R379S	NM_003073	NP_003064	Q12824	SNF5_HUMAN	SWI/SNF related, matrix associated, actin	370					cell cycle|chromatin remodeling|DNA integration|interspecies interaction between organisms|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|retroviral genome replication|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleolus|nucleoplasm|SWI/SNF complex	p53 binding	p.?(2)|p.L266_*386del(1)		soft_tissue(193)|central_nervous_system(172)|haematopoietic_and_lymphoid_tissue(23)|meninges(5)|skin(5)|bone(4)|ovary(2)|endometrium(1)|lung(1)|pancreas(1)	407		Medulloblastoma(6;2.2e-09)|all_neural(6;2.73e-05)				ACCAGGACAGGAACACGAGGT	0.622		NaN	D|N|F|S		malignant rhabdoid 	malignant rhabdoid			Rhabdoid_Predisposition_syndrome|Schwannomatosis				1	0	1.15919e-05	0.008871	1.20464e-05	17	38									
HSCB	150274	broad.mit.edu	37	22	29138168	29138168	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr22:29138168G>T	uc003aea.2	+	1	126	c.85G>T	c.(85-87)GAT>TAT	p.D29Y	CHEK2_uc003adt.1_5'Flank|CHEK2_uc003adu.1_5'Flank|CHEK2_uc003adv.1_5'Flank|CHEK2_uc003adw.1_5'Flank|CHEK2_uc003adx.1_5'Flank|CHEK2_uc003ady.1_5'Flank|CHEK2_uc003adz.1_5'Flank	NM_172002	NP_741999	Q8IWL3	HSC20_HUMAN	J-type co-chaperone HSC20 precursor	29					iron-sulfur cluster assembly|protein folding	mitochondrion	chaperone binding|heat shock protein binding|metal ion binding			kidney(1)	1						GCTAAGCTGCGATGCTGCGTC	0.682		NaN											1	0	0.00909568	0.009096	0.00928683	3	12									
TBC1D10A	83874	broad.mit.edu	37	22	30722721	30722721	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr22:30722721G>T	uc011akt.1	-	1	174	c.150C>A	c.(148-150)TTC>TTA	p.F50L	TBC1D10A_uc010gvu.2_Missense_Mutation_p.F50L|TBC1D10A_uc003ahk.3_Missense_Mutation_p.F50L	NM_031937	NP_114143	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	50						intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			ovary(1)	1						GGCGCTCGGCGAAGCCGTTGG	0.711		NaN											1	0	2.41591e-17	0.004656	2.70861e-17	19	32									
SEC14L3	266629	broad.mit.edu	37	22	30860840	30860840	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr22:30860840C>T	uc003ahy.2	-	8	720	c.631G>A	c.(631-633)GAG>AAG	p.E211K	SEC14L3_uc003ahz.2_Missense_Mutation_p.E134K|SEC14L3_uc003aia.2_Missense_Mutation_p.E152K|SEC14L3_uc003aib.2_Missense_Mutation_p.E152K	NM_174975	NP_777635	Q9UDX4	S14L3_HUMAN	SEC14-like 3	211	CRAL-TRIO.					integral to membrane|intracellular	lipid binding|transporter activity			ovary(3)|pancreas(1)|skin(1)	5					Vitamin E(DB00163)	CGAGTGTCCTCACTCAGGAAT	0.448		NaN											0	0	0	0.01441	0	60	121									
MAFF	23764	broad.mit.edu	37	22	38609853	38609853	+	Translation_Start_Site	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr22:38609853C>A	uc011anp.1	+	2	331	c.-7C>A	c.(-9--5)TTCTG>TTATG		MAFF_uc003avc.2_Translation_Start_Site|MAFF_uc011anq.1_Intron|MAFF_uc011anr.1_Translation_Start_Site|MAFF_uc003avd.2_Missense_Mutation_p.F47L	NM_001161572	NP_001155044	Q9ULX9	MAFF_HUMAN	transcription factor MAFF isoform a						blood coagulation|parturition|transcription from RNA polymerase II promoter	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Melanoma(58;0.045)					AGGGCACCTTCTGCAAACATG	0.438		NaN											1	0	2.19962e-31	0.00874	2.56476e-31	33	69									
TNRC6B	23112	broad.mit.edu	37	22	40661039	40661039	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr22:40661039C>G	uc011aor.1	+	5	1016	c.805C>G	c.(805-807)CAA>GAA	p.Q269E	TNRC6B_uc003aym.2_Intron|TNRC6B_uc003ayn.3_Missense_Mutation_p.Q269E|TNRC6B_uc003ayo.2_Missense_Mutation_p.Q73E	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	269					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0						TAAATCTGTTCAATCTTCCAA	0.453		NaN											0	0	0	0.00308	0	8	64									
TNRC6B	23112	broad.mit.edu	37	22	40662821	40662821	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr22:40662821C>T	uc011aor.1	+	5	2798	c.2587C>T	c.(2587-2589)CAG>TAG	p.Q863*	TNRC6B_uc003aym.2_Intron|TNRC6B_uc003ayn.3_Nonsense_Mutation_p.Q863*|TNRC6B_uc003ayo.2_Nonsense_Mutation_p.Q667*	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	863	Pro-rich.				gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0						CAGCGGGCCACAGCCTGCAAC	0.582		NaN											0	0	0	0.001984	0	6	23									
CHKB	1120	broad.mit.edu	37	22	51019955	51019955	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr22:51019955G>A	uc003bms.2	-	4	693	c.475C>T	c.(475-477)CGA>TGA	p.R159*	CPT1B_uc003bmo.2_5'Flank|CPT1B_uc011asa.1_5'Flank|CPT1B_uc003bmn.2_5'Flank|CPT1B_uc011asb.1_5'Flank|CHKB-CPT1B_uc003bmp.2_5'Flank|CHKB-CPT1B_uc003bmt.1_Intron|CHKB-CPT1B_uc003bmu.2_Nonsense_Mutation_p.R38*|CHKB_uc003bmv.2_Nonsense_Mutation_p.R159*|LOC100144603_uc003bmw.3_5'Flank	NM_005198	NP_005189	Q9Y259	CHKB_HUMAN	choline kinase beta	159					phosphatidylethanolamine biosynthetic process		ATP binding|choline kinase activity|ethanolamine kinase activity				0		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;4.04e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.79e-74)|Epithelial(4;6.17e-70)|GBM - Glioblastoma multiforme(4;5.68e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.205)	Choline(DB00122)	ACTGGCTCTCGAAGCTCTTGA	0.572		NaN											0	0	0	0.001855	0	11	35									
RPUSD3	285367	broad.mit.edu	37	3	9885243	9885243	+	Silent	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:9885243G>C	uc011atk.1	-	2	172	c.168C>G	c.(166-168)CCC>CCG	p.P56P	ARPC4_uc003btc.1_Intron|RPUSD3_uc011atl.1_Silent_p.P56P|RPUSD3_uc011atm.1_Silent_p.P48P|RPUSD3_uc003btn.2_Silent_p.P48P	NM_173659	NP_775930	Q6P087	RUSD3_HUMAN	RNA pseudouridylate synthase domain containing 3	56					pseudouridine synthesis		pseudouridine synthase activity|RNA binding			central_nervous_system(1)	1	Medulloblastoma(99;0.227)					GGTCCCCGAGGGGCCCCGACC	0.657		NaN											0	0	0	0.013537	0	11	23									
EFHB	151651	broad.mit.edu	37	3	19925987	19925987	+	Missense_Mutation	SNP	C	C	T	rs142916632	byFrequency	TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:19925987C>T	uc003cbl.3	-	11	2250	c.2054G>A	c.(2053-2055)CGG>CAG	p.R685Q	EFHB_uc003cbm.2_Missense_Mutation_p.R555Q	NM_144715	NP_653316	Q8N7U6	EFHB_HUMAN	EF hand domain family, member B	685				R -> W (in Ref. 1; BAC85491).	signal transduction	proteinaceous extracellular matrix	calcium ion binding				0						CAGAAGTGTCCGGAGAGTCTT	0.398		NaN											0	0	0	0.004007	0	13	32									
NR1D2	9975	broad.mit.edu	37	3	24003672	24003672	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:24003672C>T	uc003ccs.2	+	5	1041	c.722C>T	c.(721-723)TCT>TTT	p.S241F	NR1D2_uc010hfd.2_RNA|NR1D2_uc011awk.1_Missense_Mutation_p.S166F	NM_005126	NP_005117	Q14995	NR1D2_HUMAN	nuclear receptor subfamily 1, group D, member 2	241					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			urinary_tract(1)|kidney(1)|skin(1)	3						ATCAAAAGCTCTTCTCCTCCA	0.448		NaN											0	0	0	0.004007	0	14	32									
NR1D2	9975	broad.mit.edu	37	3	24003755	24003755	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:24003755C>G	uc003ccs.2	+	5	1124	c.805C>G	c.(805-807)CAA>GAA	p.Q269E	NR1D2_uc010hfd.2_RNA|NR1D2_uc011awk.1_Missense_Mutation_p.Q194E	NM_005126	NP_005117	Q14995	NR1D2_HUMAN	nuclear receptor subfamily 1, group D, member 2	269					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			urinary_tract(1)|kidney(1)|skin(1)	3						TATGTATAATCAAGAGCAGCA	0.423		NaN											0	0	0	0.00245	0	12	50									
DLEC1	9940	broad.mit.edu	37	3	38136538	38136538	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:38136538C>A	uc003cho.1	+	13	2109	c.2088C>A	c.(2086-2088)TTC>TTA	p.F696L	DLEC1_uc003chp.1_Missense_Mutation_p.F696L|DLEC1_uc010hgv.1_Missense_Mutation_p.F696L|DLEC1_uc003chr.1_5'UTR|DLEC1_uc010hgx.1_5'Flank|DLEC1_uc003chq.1_Intron	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	696					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		ACCACGAGTTCATCCTGAGCT	0.517		NaN											1	0	7.92952e-12	0.003954	8.54512e-12	15	61									
DLEC1	9940	broad.mit.edu	37	3	38136557	38136557	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:38136557C>T	uc003cho.1	+	13	2128	c.2107C>T	c.(2107-2109)CAT>TAT	p.H703Y	DLEC1_uc003chp.1_Missense_Mutation_p.H703Y|DLEC1_uc010hgv.1_Missense_Mutation_p.H703Y|DLEC1_uc003chr.1_5'UTR|DLEC1_uc010hgx.1_5'Flank|DLEC1_uc003chq.1_Intron	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	703					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		CTTTTCTCCTCATGAGGTTCA	0.527		NaN											0	0	0	0.008871	0	15	53									
DLEC1	9940	broad.mit.edu	37	3	38138129	38138129	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:38138129G>A	uc003cho.1	+	15	2262	c.2241G>A	c.(2239-2241)GTG>GTA	p.V747V	DLEC1_uc003chp.1_Silent_p.V747V|DLEC1_uc010hgv.1_Silent_p.V747V|DLEC1_uc003chr.1_5'UTR|DLEC1_uc010hgx.1_RNA	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	747					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		AAATCGAGGTGAAAGGCTCAG	0.493		NaN											0	0	0	0.01441	0	43	77									
TMEM89	440955	broad.mit.edu	37	3	48658340	48658340	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:48658340G>T	uc011bbo.1	-	2	415	c.415C>A	c.(415-417)CAC>AAC	p.H139N		NM_001008269	NP_001008270	A2RUT3	TMM89_HUMAN	transmembrane protein 89 precursor	139	Cytoplasmic (Potential).					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(193;0.000286)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		TGACGTAGGTGGCCTTCGATG	0.612		NaN											1	0	4.65686e-17	0.003755	5.20106e-17	35	86									
CELSR3	1951	broad.mit.edu	37	3	48675652	48675652	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:48675652C>A	uc003cul.2	-	35	10206	c.9925G>T	c.(9925-9927)GAG>TAG	p.E3309*	CELSR3_uc003cuf.1_Intron|SLC26A6_uc003cuh.2_5'Flank|SLC26A6_uc010hke.2_5'Flank|SLC26A6_uc003cuk.2_5'Flank|SLC26A6_uc003cui.2_5'Flank|SLC26A6_uc003cuj.2_5'Flank|SLC26A6_uc011bbp.1_5'Flank|CELSR3_uc010hkf.2_Nonsense_Mutation_p.E599*|CELSR3_uc010hkg.2_Nonsense_Mutation_p.E1292*	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	3309	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GAGTGACCCTCACTTCTGGGA	0.607		NaN											1	0	6.00712e-18	0.012213	6.76091e-18	21	55									
CELSR3	1951	broad.mit.edu	37	3	48694197	48694197	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:48694197G>C	uc003cul.2	-	2	4614	c.4333C>G	c.(4333-4335)CGC>GGC	p.R1445G	CELSR3_uc003cuf.1_Missense_Mutation_p.R1515G	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	1445	Extracellular (Potential).|EGF-like 2; calcium-binding.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CCGCCGTTGCGACATGGGTTG	0.711		NaN											0	0	0	0.004672	0	2	8									
CELSR3	1951	broad.mit.edu	37	3	48698429	48698429	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:48698429C>T	uc003cul.2	-	1	1920	c.1639G>A	c.(1639-1641)GAG>AAG	p.E547K	CELSR3_uc003cuf.1_Missense_Mutation_p.E617K	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	547	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TAGCGCTTCTCGCTGAACTGA	0.652		NaN											0	0	0	0.00333	0	22	34									
QRICH1	54870	broad.mit.edu	37	3	49094498	49094498	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49094498G>A	uc010hkq.2	-	4	1431	c.1135C>T	c.(1135-1137)CTT>TTT	p.L379F	QRICH1_uc003cvu.2_Missense_Mutation_p.L379F|QRICH1_uc003cvv.2_Missense_Mutation_p.L379F	NM_198880	NP_942581	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	379	Gln-rich.									ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		GAGTTTGCAAGGGTCTGCACT	0.522		NaN											0	0	0	0.004656	0	24	55									
KLHDC8B	200942	broad.mit.edu	37	3	49212384	49212384	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49212384T>G	uc003cwh.2	+	4	936	c.751T>G	c.(751-753)TTT>GTT	p.F251V	KLHDC8B_uc003cwi.1_Missense_Mutation_p.F124V	NM_173546	NP_775817	Q8IXV7	KLD8B_HUMAN	kelch domain containing 8B	251	Kelch 6.					cytoplasm					0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TGTGGAGATGTTTGACCTGGA	0.587		NaN											0	0	0	0.003163	0	12	82									
USP4	7375	broad.mit.edu	37	3	49362149	49362149	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49362149C>G	uc003cwq.2	-	6	760	c.681G>C	c.(679-681)CAG>CAC	p.Q227H	USP4_uc003cwr.2_Missense_Mutation_p.Q227H	NM_003363	NP_003354	Q13107	UBP4_HUMAN	ubiquitin specific protease 4 isoform a	227					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		ACTGCAAGGTCTGCCTGGGCC	0.438		NaN											0	0	0	0.004007	0	13	90									
USP4	7375	broad.mit.edu	37	3	49362462	49362462	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49362462C>A	uc003cwq.2	-	5	577	c.498G>T	c.(496-498)GAG>GAT	p.E166D	USP4_uc003cwr.2_Missense_Mutation_p.E166D	NM_003363	NP_003354	Q13107	UBP4_HUMAN	ubiquitin specific protease 4 isoform a	166					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		GCATCTCTTTCTCGATGGTTG	0.478		NaN											1	0	3.73808e-20	0.005443	4.29843e-20	21	131									
DAG1	1605	broad.mit.edu	37	3	49568599	49568599	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49568599G>A	uc003cxc.3	+	3	1073	c.655G>A	c.(655-657)GAA>AAA	p.E219K		NM_004393	NP_004384	Q14118	DAG1_HUMAN	dystroglycan 1 preproprotein	219	Required for laminin recognition.				cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of cell migration|negative regulation of MAPKKK cascade|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		GAGCTTCTCAGAAGTAGAGCT	0.488		NaN											0	0	0	0.00333	0	20	45									
BSN	8927	broad.mit.edu	37	3	49691151	49691151	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49691151C>A	uc003cxe.3	+	5	4276	c.4162C>A	c.(4162-4164)CCT>ACT	p.P1388T		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	1388					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		AGCTGTGGCTCCTTGTCCAGC	0.622		NaN											1	0	4.3181e-19	0.013726	4.90731e-19	32	62									
AMIGO3	386724	broad.mit.edu	37	3	49756782	49756782	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49756782G>C	uc003cxj.2	-	1	457	c.117C>G	c.(115-117)ATC>ATG	p.I39M	RNF123_uc003cxh.2_Intron|RNF123_uc003cxi.2_Intron	NM_198722	NP_942015	Q86WK7	AMGO3_HUMAN	adhesion molecule with Ig-like domain 3	39	Extracellular (Potential).|LRRNT.				heterophilic cell-cell adhesion	integral to membrane				pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CGGCAGCGCAGATACATTTGT	0.652		NaN									OREG0015572	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00333	0	17	144									
GMPPB	29925	broad.mit.edu	37	3	49759447	49759447	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49759447G>A	uc003cxk.1	-	8	1127	c.902C>T	c.(901-903)TCC>TTC	p.S301F	AMIGO3_uc003cxj.2_5'Flank|GMPPB_uc003cxl.1_Missense_Mutation_p.S301F	NM_021971	NP_068806	Q9Y5P6	GMPPB_HUMAN	GDP-mannose pyrophosphorylase B isoform 2	301					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity				0				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CTCAAGCCAGGAATGGGAACG	0.667		NaN											0	0	0	0.006122	0	12	114									
MST1R	4486	broad.mit.edu	37	3	49927421	49927421	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49927421C>G	uc003cxy.3	-	19	4147	c.3883G>C	c.(3883-3885)GAC>CAC	p.D1295H	MST1R_uc011bdc.1_Missense_Mutation_p.D174H	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	1295	Cytoplasmic (Potential).|Protein kinase.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		TGGGTAAGGTCAAAAGGGTCA	0.532		NaN											0	0	0	0.011902	0	35	82									
PARP3	10039	broad.mit.edu	37	3	51979599	51979599	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:51979599G>T	uc003dby.2	+	7	1321	c.950G>T	c.(949-951)CGA>CTA	p.R317L	PARP3_uc003dbz.2_Missense_Mutation_p.R324L	NM_005485	NP_005476	Q9Y6F1	PARP3_HUMAN	poly (ADP-ribose) polymerase family, member 3	317	PARP catalytic.				DNA repair|protein ADP-ribosylation	centriole|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CCCCTGGACCGAGACTACCAG	0.627		NaN											1	0	1.59932e-28	0.007835	1.85738e-28	32	61									
FAM116A	201627	broad.mit.edu	37	3	57649368	57649368	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:57649368G>C	uc003dja.2	-	5	579	c.508C>G	c.(508-510)CAG>GAG	p.Q170E		NM_152678	NP_689891	Q8IWF6	F116A_HUMAN	hypothetical protein LOC201627	170										pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000621)|KIRC - Kidney renal clear cell carcinoma(284;0.0485)|Kidney(284;0.0607)		ATTACCTTCTGAAAGTAGCCT	0.289		NaN											0	0	0	0.003271	0	25	68									
ADAMTS9	56999	broad.mit.edu	37	3	64607917	64607917	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:64607917C>A	uc003dmg.2	-	18	2675	c.2643G>T	c.(2641-2643)TGG>TGT	p.W881C	ADAMTS9_uc011bfo.1_Missense_Mutation_p.W853C|ADAMTS9_uc003dmh.1_Missense_Mutation_p.W710C|ADAMTS9_uc003dmk.1_Missense_Mutation_p.W881C	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	881	TSP type-1 2.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CATGACTGTTCCAGTAAAACT	0.393		NaN											1	0	1.57945e-13	0.011902	1.71795e-13	35	68									
UBA3	9039	broad.mit.edu	37	3	69124658	69124658	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:69124658G>C	uc003dno.2	-	4	207	c.187C>G	c.(187-189)CTC>GTC	p.L63V	UBA3_uc003dnq.2_Missense_Mutation_p.L49V|UBA3_uc011bfy.1_5'UTR|UBA3_uc011bfz.1_Intron	NM_003968	NP_003959	Q8TBC4	UBA3_HUMAN	ubiquitin-activating enzyme 3 isoform 1	63	Interaction with UBE2M N-terminus.				protein neddylation|proteolysis	nucleus	acid-amino acid ligase activity|ATP binding|protein heterodimerization activity			ovary(1)	1		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.98e-05)|Epithelial(33;0.000363)|LUSC - Lung squamous cell carcinoma(21;0.012)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.206)|Kidney(39;0.241)		AAGAACTGGAGAGACTGTAAA	0.338		NaN											0	0	0	0.010504	0	16	39									
FRMD4B	23150	broad.mit.edu	37	3	69246184	69246184	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:69246184G>C	uc003dnv.2	-	13	1249	c.959C>G	c.(958-960)TCA>TGA	p.S320*	FRMD4B_uc003dnw.2_Intron|FRMD4B_uc003dnu.2_5'UTR|FRMD4B_uc011bga.1_Nonsense_Mutation_p.S164*	NM_015123	NP_055938	Q9Y2L6	FRM4B_HUMAN	FERM domain containing 4B	320	FERM.					cytoplasm|cytoskeleton	binding			ovary(3)|central_nervous_system(1)	4		Lung NSC(201;0.0138)|Prostate(884;0.11)		BRCA - Breast invasive adenocarcinoma(55;0.000201)|Epithelial(33;0.00141)|LUSC - Lung squamous cell carcinoma(21;0.00999)|Lung(16;0.0182)		TCTTGAAACTGAAATCCTGAA	0.418		NaN											0	0	0	0.00499	0	13	19									
EIF4E3	317649	broad.mit.edu	37	3	71743081	71743081	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:71743081C>G	uc003dov.3	-	5	425	c.417G>C	c.(415-417)TGG>TGC	p.W139C	EIF4E3_uc011bgc.1_Missense_Mutation_p.W33C|EIF4E3_uc003dox.2_Missense_Mutation_p.W33C|EIF4E3_uc011bgd.1_Missense_Mutation_p.W33C|EIF4E3_uc010hoc.2_Missense_Mutation_p.W33C	NM_001134651	NP_001128123	Q8N5X7	IF4E3_HUMAN	eukaryotic translation initiation factor 4E	139					regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity				0		Prostate(10;0.0166)		BRCA - Breast invasive adenocarcinoma(55;2.56e-05)|Epithelial(33;2.9e-05)|Lung(16;9.28e-05)|LUSC - Lung squamous cell carcinoma(21;0.00227)		GCAACTCTTTCCAAACTGTGG	0.448		NaN											0	0	0	0.009096	0	3	10									
OR5H1	26341	broad.mit.edu	37	3	97852160	97852160	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:97852160C>G	uc011bgt.1	+	1	619	c.619C>G	c.(619-621)CAG>GAG	p.Q207E		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	207	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						AGGTTCAATTCAGGTATTCAG	0.313		NaN											0	0	0	0.001984	0	6	33									
PHLDB2	90102	broad.mit.edu	37	3	111686606	111686606	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:111686606G>A	uc010hqa.2	+	15	3661	c.3250G>A	c.(3250-3252)GAA>AAA	p.E1084K	PHLDB2_uc003dyc.2_Missense_Mutation_p.E1068K|PHLDB2_uc003dyd.2_Missense_Mutation_p.E1041K|PHLDB2_uc003dyg.2_Missense_Mutation_p.E1084K|PHLDB2_uc003dyh.2_Missense_Mutation_p.E1041K|PHLDB2_uc003dyi.2_Missense_Mutation_p.E575K|PHLDB2_uc003dyj.2_Missense_Mutation_p.E139K	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	1084	Potential.					cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						ATTACAGGAAGAAACTAGCCA	0.433		NaN									OREG0015707	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001168	0	6	22									
KIAA2018	205717	broad.mit.edu	37	3	113376375	113376375	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:113376375G>A	uc003eam.2	-	7	4565	c.4154C>T	c.(4153-4155)TCA>TTA	p.S1385L	KIAA2018_uc003eal.2_Missense_Mutation_p.S1329L	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	1385					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						AGGCACAACTGAGTTTGAAGA	0.448		NaN											0	0	0	0.00245	0	13	53									
ZBTB20	26137	broad.mit.edu	37	3	114070334	114070334	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:114070334C>T	uc003ebi.2	-	4	771	c.591G>A	c.(589-591)GTG>GTA	p.V197V	ZBTB20_uc003ebj.2_Silent_p.V124V|ZBTB20_uc010hqp.2_Silent_p.V124V|ZBTB20_uc003ebk.2_Silent_p.V124V|ZBTB20_uc003ebl.2_Silent_p.V124V|ZBTB20_uc003ebm.2_Silent_p.V124V|ZBTB20_uc003ebn.2_Silent_p.V124V|uc003ebo.1_5'Flank	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	197					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		ACACATCGCCCACGTTCTGTG	0.652		NaN											0	0	0	0.010729	0	10	79									
ACPP	55	broad.mit.edu	37	3	132068810	132068810	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:132068810G>C	uc010htp.2	+	8	918	c.828G>C	c.(826-828)CAG>CAC	p.Q276H	ACPP_uc003eon.3_Missense_Mutation_p.Q243H|ACPP_uc003eop.3_Missense_Mutation_p.Q276H	NM_001099	NP_001090	P15309	PPAP_HUMAN	acid phosphatase, prostate short isoform	276						extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			ovary(1)	1						GAGCAACTCAGATACCAAGCT	0.299		NaN											0	0	0	0.006214	0	10	61									
CEP63	80254	broad.mit.edu	37	3	134278032	134278032	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:134278032G>A	uc003eqo.1	+	15	2163	c.1714G>A	c.(1714-1716)GAG>AAG	p.E572K	CEP63_uc003eql.1_Intron|CEP63_uc003eqm.2_Intron|CEP63_uc003eqn.1_Intron	NM_025180	NP_079456	Q96MT8	CEP63_HUMAN	centrosomal protein 63 isoform a	572					cell division|DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitosis|signal transduction in response to DNA damage|spindle assembly	centrosome|cytosol|spindle pole	protein binding			ovary(1)	1						AATAAAGACTGAGCACTACAA	0.433		NaN											0	0	0	0.01441	0	56	103									
DZIP1L	199221	broad.mit.edu	37	3	137822364	137822364	+	Silent	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:137822364G>T	uc003erq.2	-	2	813	c.450C>A	c.(448-450)ATC>ATA	p.I150I	DZIP1L_uc003err.1_Silent_p.I150I	NM_173543	NP_775814	Q8IYY4	DZI1L_HUMAN	DAZ interacting protein 1-like	150						intracellular	zinc ion binding			ovary(1)|pancreas(1)	2						GCAGGGTGCTGATCATCTTGC	0.662		NaN											1	0	2.27111e-07	0.013537	2.39432e-07	12	26									
SMC4	10051	broad.mit.edu	37	3	160148850	160148850	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:160148850C>T	uc003fdh.2	+	20	3084	c.2971C>T	c.(2971-2973)CGC>TGC	p.R991C	IFT80_uc003fda.2_Intron|SMC4_uc003fdi.2_Missense_Mutation_p.R966C|SMC4_uc003fdj.2_Missense_Mutation_p.R991C|SMC4_uc010hwd.2_Intron|SMC4_uc003fdl.2_Missense_Mutation_p.R694C	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	991	Potential.				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GAAAGAACATCGCAATCTGCT	0.333		NaN											0	0	0	0.014323	0	21	50									
SAMD7	344658	broad.mit.edu	37	3	169654187	169654187	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:169654187C>T	uc003fgd.2	+	8	1369	c.1102C>T	c.(1102-1104)CGA>TGA	p.R368*	SAMD7_uc003fge.2_Nonsense_Mutation_p.R368*|SAMD7_uc011bpo.1_Nonsense_Mutation_p.R269*	NM_182610	NP_872416	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	368	SAM.									skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			AGAGCATCTTCGAGGCACTAT	0.353		NaN											0	0	0	0.008871	0	15	91									
FETUB	26998	broad.mit.edu	37	3	186370280	186370280	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:186370280G>A	uc010hyq.2	+	8	1270	c.1009G>A	c.(1009-1011)GAA>AAA	p.E337K	FETUB_uc011brz.1_Missense_Mutation_p.E189K|FETUB_uc003fqn.2_Missense_Mutation_p.E337K|FETUB_uc003fqo.2_Missense_Mutation_p.E232K|FETUB_uc010hyr.2_Missense_Mutation_p.E300K|FETUB_uc010hys.2_Missense_Mutation_p.E189K|FETUB_uc003fqp.3_Missense_Mutation_p.E272K	NM_014375	NP_055190	Q9UGM5	FETUB_HUMAN	fetuin B precursor	337						extracellular space	cysteine-type endopeptidase inhibitor activity			ovary(1)|lung(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		TCCCCAGGGAGAAACCCTGGA	0.522		NaN											0	0	0	0.012319	0	17	98									
RFC4	5984	broad.mit.edu	37	3	186509528	186509528	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:186509528T>C	uc003fqz.2	-	8	1010	c.787A>G	c.(787-789)ACA>GCA	p.T263A	RFC4_uc011bsc.1_Missense_Mutation_p.T263A|RFC4_uc011bsd.1_Missense_Mutation_p.T263A	NM_002916	NP_002907	P35249	RFC4_HUMAN	replication factor C 4	263					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|large_intestine(1)	5	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		GCAATGTCTGTAATCACTTTC	0.328		NaN											0	0	0	0.004672	0	3	126									
TNIP2	79155	broad.mit.edu	37	4	2746230	2746230	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr4:2746230G>A	uc003gfg.2	-	5	997	c.910C>T	c.(910-912)CTC>TTC	p.L304F	TNIP2_uc003gff.2_Missense_Mutation_p.L197F|TNIP2_uc003gfh.2_Missense_Mutation_p.L221F	NM_024309	NP_077285	Q8NFZ5	TNIP2_HUMAN	A20-binding inhibitor of NF-kappaB activation 2	304	Potential.					cytosol	protein binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TTGTAAGCGAGAATCTGAAGA	0.552		NaN											0	0	0	0.008361	0	23	44									
RASL11B	65997	broad.mit.edu	37	4	53728708	53728708	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr4:53728708G>A	uc003gzt.2	+	1	214	c.34G>A	c.(34-36)GAG>AAG	p.E12K		NM_023940	NP_076429	Q9BPW5	RSLBB_HUMAN	RAS-like family 11 member B	12					small GTPase mediated signal transduction	membrane	GTP binding|GTPase activity			central_nervous_system(1)	1			LUSC - Lung squamous cell carcinoma(32;0.0302)			CACCATCGCCGAGTACCCCGC	0.731		NaN											0	0	0	0.00308	0	7	25									
PTPN13	5783	broad.mit.edu	37	4	87622590	87622590	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr4:87622590C>G	uc003hpz.2	+	7	1311	c.831C>G	c.(829-831)TTC>TTG	p.F277L	PTPN13_uc003hpy.2_Missense_Mutation_p.F277L|PTPN13_uc003hqa.2_Missense_Mutation_p.F277L|PTPN13_uc003hqb.2_Missense_Mutation_p.F277L	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	277						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		CTTACCAGTTCAAAACTAGTG	0.393		NaN											0	0	0	0.004482	0	7	11									
PALLD	23022	broad.mit.edu	37	4	169433469	169433469	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr4:169433469C>G	uc011cjx.1	+	2	1025	c.814C>G	c.(814-816)CGA>GGA	p.R272G	PALLD_uc003iru.2_Missense_Mutation_p.R272G	NM_016081	NP_057165	Q8WX93	PALLD_HUMAN	palladin isoform 2	272	Ig-like C2-type 1.				cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			ovary(1)	1		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		AGCTGCACCTCGATTCATCCA	0.567		NaN							Pancreatic_Cancer_Familial_Clustering_of				0	0	0	0.001168	0	4	41									
SLC6A18	348932	broad.mit.edu	37	5	1245984	1245984	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:1245984G>C	uc003jby.1	+	12	1801	c.1678G>C	c.(1678-1680)GAG>CAG	p.E560Q		NM_182632	NP_872438	Q96N87	S6A18_HUMAN	solute carrier family 6, member 18	560	Extracellular (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CTCGCGTCAGGAGAAGCTCTA	0.706		NaN											0	0	0	0.001168	0	5	34									
CCT5	22948	broad.mit.edu	37	5	10258507	10258507	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:10258507G>A	uc003jeq.2	+	6	904	c.733G>A	c.(733-735)GAT>AAT	p.D245N	CCT5_uc011cmq.1_Missense_Mutation_p.D92N|CCT5_uc003jer.2_Missense_Mutation_p.D245N|CCT5_uc010its.2_Missense_Mutation_p.D245N|CCT5_uc011cmr.1_Missense_Mutation_p.D190N|CCT5_uc011cms.1_Missense_Mutation_p.D207N|CCT5_uc011cmt.1_Missense_Mutation_p.D152N	NM_012073	NP_036205	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	245					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			ovary(2)	2						GAAAGTGGAAGATGCGAAGAT	0.408		NaN											0	0	0	0.010504	0	17	109									
DNAH5	1767	broad.mit.edu	37	5	13708301	13708301	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:13708301G>A	uc003jfd.2	-	76	13311	c.13269C>T	c.(13267-13269)ATC>ATT	p.I4423I	DNAH5_uc003jfc.2_Silent_p.I591I	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4423					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TTTCGCTCATGATGATGGTGC	0.458		NaN							Kartagener_syndrome				0	0	0	0.01441	0	73	198									
UGT3A1	133688	broad.mit.edu	37	5	35965895	35965895	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:35965895C>T	uc003jjv.1	-	4	593	c.436G>A	c.(436-438)GCA>ACA	p.A146T	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Missense_Mutation_p.A146T|UGT3A1_uc011cor.1_Missense_Mutation_p.A112T|UGT3A1_uc003jjy.1_Missense_Mutation_p.A92T	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	146	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AAATCAAATGCTTCAACAAAT	0.383		NaN											0	0	0	0.003954	0	21	36									
RICTOR	253260	broad.mit.edu	37	5	38952313	38952313	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:38952313C>A	uc003jlp.2	-	30	3136	c.3112G>T	c.(3112-3114)GAA>TAA	p.E1038*	RICTOR_uc003jlo.2_Nonsense_Mutation_p.E1038*|RICTOR_uc010ivf.2_Nonsense_Mutation_p.E753*	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	1038	Ser-rich.				actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					GGCACAGATTCACTTTCACTA	0.343		NaN											1	0	1.1804e-14	0.003954	1.30089e-14	21	23									
PPAP2A	8611	broad.mit.edu	37	5	54721117	54721117	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:54721117C>G	uc003jqa.2	-	6	1188	c.772G>C	c.(772-774)GAA>CAA	p.E258Q	SKIV2L2_uc003jpy.3_3'UTR|SKIV2L2_uc011cqi.1_3'UTR|PPAP2A_uc003jpz.2_Missense_Mutation_p.E259Q|PPAP2A_uc003jqb.2_RNA	NM_003711	NP_003702	O14494	LPP1_HUMAN	phosphatidic acid phosphatase type 2A isoform 1	258	Cytoplasmic (Potential).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|androgen receptor signaling pathway|germ cell migration|negative regulation of cell proliferation|phospholipid dephosphorylation|regulation of lipid metabolic process|sphingolipid metabolic process	integral to plasma membrane|membrane fraction	phosphatidate phosphatase activity|sphingosine-1-phosphate phosphatase activity			ovary(2)	2		Lung NSC(810;4.08e-05)|Prostate(74;0.0181)|Breast(144;0.0544)				TCTTTTCTTTCTTTAAAAGAA	0.378		NaN											0	0	0	0.00308	0	6	39									
PPAP2A	8611	broad.mit.edu	37	5	54721830	54721830	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:54721830C>G	uc003jqa.2	-	5	1003	c.587G>C	c.(586-588)AGA>ACA	p.R196T	PPAP2A_uc003jpz.2_Missense_Mutation_p.R197T|PPAP2A_uc003jqb.2_RNA	NM_003711	NP_003702	O14494	LPP1_HUMAN	phosphatidic acid phosphatase type 2A isoform 1	196	Cytoplasmic (Potential).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|androgen receptor signaling pathway|germ cell migration|negative regulation of cell proliferation|phospholipid dephosphorylation|regulation of lipid metabolic process|sphingolipid metabolic process	integral to plasma membrane|membrane fraction	phosphatidate phosphatase activity|sphingosine-1-phosphate phosphatase activity			ovary(2)	2		Lung NSC(810;4.08e-05)|Prostate(74;0.0181)|Breast(144;0.0544)				GCGTAAGAGTCTTGCCCAGTC	0.378		NaN											0	0	0	0.001855	0	11	55									
PPAP2A	8611	broad.mit.edu	37	5	54737722	54737722	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:54737722G>C	uc003jqa.2	-	4	922	c.506C>G	c.(505-507)TCA>TGA	p.S169*	PPAP2A_uc003jpz.2_Nonsense_Mutation_p.S170*|PPAP2A_uc003jqb.2_RNA	NM_003711	NP_003702	O14494	LPP1_HUMAN	phosphatidic acid phosphatase type 2A isoform 1	169	Helical; (Potential).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|androgen receptor signaling pathway|germ cell migration|negative regulation of cell proliferation|phospholipid dephosphorylation|regulation of lipid metabolic process|sphingolipid metabolic process	integral to plasma membrane|membrane fraction	phosphatidate phosphatase activity|sphingosine-1-phosphate phosphatase activity			ovary(2)	2		Lung NSC(810;4.08e-05)|Prostate(74;0.0181)|Breast(144;0.0544)				AGAGTGGCCTGAATAGAAGGA	0.393		NaN											0	0	0	0.008361	0	26	45									
CHD1	1105	broad.mit.edu	37	5	98215419	98215419	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:98215419G>C	uc003knf.2	-	22	3222	c.3074C>G	c.(3073-3075)TCA>TGA	p.S1025*		NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	1025					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	ATCCATATTTGAGAAGTTGGC	0.343		NaN											0	0	0	0.009096	0	3	10									
WDR36	134430	broad.mit.edu	37	5	110428137	110428137	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:110428137G>C	uc003kpd.2	+	1	268	c.151G>C	c.(151-153)GCT>CCT	p.A51P	WDR36_uc010jbu.2_RNA	NM_139281	NP_644810	Q8NI36	WDR36_HUMAN	WD repeat domain 36	51					response to stimulus|rRNA processing|visual perception	small-subunit processome				ovary(1)|skin(1)	2		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		GCTGAGAGGAGCTGGGATCGC	0.602		NaN											0	0	0	0.008291	0	7	48									
SRP19	6728	broad.mit.edu	37	5	112227372	112227372	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:112227372G>C	uc011cvv.1	+	4	366	c.111G>C	c.(109-111)AAG>AAC	p.K37N	SRP19_uc011cvu.1_Missense_Mutation_p.K22N|REEP5_uc011cvw.1_Intron|REEP5_uc003kqe.1_Intron|REEP5_uc011cvx.1_Intron|REEP5_uc011cvy.1_Intron|REEP5_uc011cvz.1_Intron			P09132	SRP19_HUMAN	SubName: Full=Zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2;	Error:Variant_position_missing_in_P09132_after_alignment					response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|mitochondrion|nucleolus|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding				0		all_cancers(142;0.00328)|all_epithelial(76;6.39e-05)|Prostate(80;0.00174)|Colorectal(10;0.00372)|Ovarian(225;0.156)		Epithelial(69;1.7e-09)|OV - Ovarian serous cystadenocarcinoma(64;1.17e-08)|all cancers(49;3.96e-07)|Colorectal(14;0.0056)|COAD - Colon adenocarcinoma(37;0.0104)		TTCCCAAGAAGATGACATTTC	0.473		NaN											0	0	0	0.009096	0	4	11									
PHF15	23338	broad.mit.edu	37	5	133914845	133914845	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:133914845G>A	uc003kzo.1	+	11	2390	c.2211G>A	c.(2209-2211)GAG>GAA	p.E737E	PHF15_uc011cxt.1_Silent_p.E781E|PHF15_uc003kzk.2_Silent_p.E797E|PHF15_uc003kzm.2_Silent_p.E738E|PHF15_uc003kzn.2_3'UTR	NM_015288	NP_056103	Q9NQC1	JADE2_HUMAN	PHD finger protein 15	737					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTGTGGCTGAGAGGCCCAAGG	0.622		NaN											0	0	0	0.008291	0	9	62									
SEC24A	10802	broad.mit.edu	37	5	134029515	134029515	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:134029515G>A	uc003kzs.2	+	13	2166	c.1878G>A	c.(1876-1878)CTG>CTA	p.L626L	SEC24A_uc011cxu.1_Silent_p.L390L	NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A	626					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCTTTAAGCTGATGTCTCCAA	0.498		NaN											0	0	0	0.006214	0	9	48									
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139916980	139916980	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:139916980C>G	uc003lfs.1	+	31	7158	c.7034C>G	c.(7033-7035)TCT>TGT	p.S2345C	ANKHD1_uc003lfr.2_Missense_Mutation_p.S2345C|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.S1101C|ANKHD1_uc003lfw.2_Missense_Mutation_p.S1000C|ANKHD1_uc010jfl.2_Missense_Mutation_p.S721C|ANKHD1-EIF4EBP3_uc003lfx.1_Missense_Mutation_p.S499C	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	2345						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAGCCACTTCTGCCCCACCA	0.453		NaN											0	0	0	0.010818	0	25	91									
APBB3	10307	broad.mit.edu	37	5	139941016	139941016	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:139941016C>A	uc003lgd.1	-	8	1140	c.781G>T	c.(781-783)GAG>TAG	p.E261*	APBB3_uc003lgb.1_Nonsense_Mutation_p.E33*|APBB3_uc003lgc.1_Nonsense_Mutation_p.E33*|APBB3_uc003lge.1_Nonsense_Mutation_p.E254*|APBB3_uc003lgf.1_RNA|APBB3_uc010jfp.1_RNA|APBB3_uc011czi.1_Nonsense_Mutation_p.E33*|APBB3_uc010jfq.1_Nonsense_Mutation_p.E33*	NM_133172	NP_573418	O95704	APBB3_HUMAN	amyloid beta precursor protein-binding, family	256	PID 1.					actin cytoskeleton|cytoplasm				ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCACTGACCTCTACTCGCTCT	0.547		NaN											1	0	8.24728e-16	0.004656	9.17589e-16	23	141									
PCDHA12	56137	broad.mit.edu	37	5	140257094	140257094	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:140257094G>A	uc003lic.2	+	1	2164	c.2037G>A	c.(2035-2037)TCG>TCA	p.S679S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Silent_p.S679S	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	679	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAAAGACGTCGTCGCGGGCCT	0.657		NaN											0	0	0	0.004672	0	3	37									
PCDHGA10	56106	broad.mit.edu	37	5	140795020	140795020	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:140795020G>A	uc003lkl.1	+	1	2278	c.2278G>A	c.(2278-2280)GAG>AAG	p.E760K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Missense_Mutation_p.E760K|PCDHGB7_uc003lkm.2_5'Flank|PCDHGB7_uc003lkn.1_5'Flank	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	760	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTATTCCCACGAGGTCTCTCT	0.602		NaN											0	0	0	0.01441	0	56	107									
PCDH12	51294	broad.mit.edu	37	5	141334867	141334867	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:141334867G>C	uc003llx.2	-	1	3761	c.2550C>G	c.(2548-2550)TTC>TTG	p.F850L		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	850	Cytoplasmic (Potential).				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGGATGGTTGAAAAGGAGGT	0.627		NaN											0	0	0	0.014323	0	18	70									
PCDH12	51294	broad.mit.edu	37	5	141336269	141336269	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:141336269G>A	uc003llx.2	-	1	2359	c.1148C>T	c.(1147-1149)TCA>TTA	p.S383L		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	383	Cadherin 4.|Extracellular (Potential).				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTGTGTCCTGAATCCAAGTC	0.507		NaN											0	0	0	0.00278	0	20	94									
SLC36A3	285641	broad.mit.edu	37	5	150675819	150675819	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:150675819A>G	uc003ltw.2	-	3	649	c.230T>C	c.(229-231)GTC>GCC	p.V77A	GM2A_uc011dcs.1_Intron|SLC36A3_uc003ltv.2_Missense_Mutation_p.V21A|SLC36A3_uc003ltx.2_Missense_Mutation_p.V77A	NM_181774	NP_861439	Q495N2	S36A3_HUMAN	solute carrier family 36, member 3 isoform 2	77	Helical; (Potential).					integral to membrane				ovary(2)|skin(1)	3		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAGAAGGCTGACAGGACCGAC	0.597		NaN											0	0	0	0.00308	0	7	30									
NOP16	51491	broad.mit.edu	37	5	175811345	175811345	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr5:175811345G>C	uc011dfl.1	-	5	424	c.424C>G	c.(424-426)CAA>GAA	p.Q142E	NOP16_uc003med.2_Intron|NOP16_uc003mee.2_Intron	NM_016391	NP_057475	Q9Y3C1	NOP16_HUMAN	NOP16 nucleolar protein homolog	142						nucleolus				ovary(1)|central_nervous_system(1)	2						GGGGTATCTTGATAGTAATTC	0.448		NaN											0	0	0	0.001168	0	6	45									
GPLD1	2822	broad.mit.edu	37	6	24486344	24486344	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:24486344C>T	uc003ned.1	-	2	223	c.112G>A	c.(112-114)GAG>AAG	p.E38K	GPLD1_uc010jps.1_Missense_Mutation_p.E38K|GPLD1_uc003nee.2_Missense_Mutation_p.E38K	NM_001503	NP_001494	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific	38						extracellular region	glycosylphosphatidylinositol phospholipase D activity			ovary(2)|kidney(1)	3						TGAAGAAACTCCAGAGCTCTG	0.323		NaN											0	0	0	0.009535	0	20	129									
HIST1H1C	3006	broad.mit.edu	37	6	26056443	26056443	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:26056443C>G	uc003nfw.2	-	1	257	c.214G>C	c.(214-216)GAT>CAT	p.D72H		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	72	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						TTCTCCACATCATAGCCGGCG	0.557		NaN											0	0	0	0.010504	0	18	87									
HIST1H1T	3010	broad.mit.edu	37	6	26108038	26108038	+	Missense_Mutation	SNP	C	C	A	rs147905742		TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:26108038C>A	uc003ngj.2	-	1	327	c.284G>T	c.(283-285)GGA>GTA	p.G95V		NM_005323	NP_005314	P22492	H1T_HUMAN	histone cluster 1, H1t	95	H15.				cell differentiation|multicellular organismal development|nucleosome assembly|spermatogenesis	nucleosome	DNA binding			ovary(2)	2						CACCAGGATTCCCTTGTTCAC	0.478		NaN											1	0	1.17739e-12	0.005443	1.27825e-12	23	55									
HIST1H2AG	8969	broad.mit.edu	37	6	27100906	27100906	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:27100906C>T	uc003niw.2	+	1	90	c.56C>T	c.(55-57)TCT>TTT	p.S19F	HIST1H2BJ_uc003niu.1_5'Flank|HIST1H2BJ_uc003niv.2_5'Flank	NM_021064	NP_066408	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ag	19					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						AAGACTCGCTCTTCTAGGGCC	0.642		NaN											0	0	0	0.00632	0	24	34									
HIST1H2AK	8330	broad.mit.edu	37	6	27805994	27805994	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:27805994C>T	uc003njs.2	-	1	124	c.124G>A	c.(124-126)GAG>AAG	p.E42K	HIST1H2BN_uc003njt.1_5'Flank|HIST1H2BN_uc003nju.1_5'Flank|HIST1H2BN_uc003njv.2_5'Flank	NM_003510	NP_003501	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ak	42					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			upper_aerodigestive_tract(1)	1						CCGACCCGCTCAGCGTAGTTG	0.657		NaN											0	0	0	0.00245	0	12	38									
DDR1	780	broad.mit.edu	37	6	30865172	30865172	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:30865172G>C	uc003nrr.2	+	16	2273	c.2014G>C	c.(2014-2016)GAG>CAG	p.E672Q	DDR1_uc010jse.2_Missense_Mutation_p.E635Q|DDR1_uc003nrq.2_Missense_Mutation_p.E635Q|DDR1_uc003nrs.2_Missense_Mutation_p.E672Q|DDR1_uc003nrt.2_Missense_Mutation_p.E635Q|DDR1_uc011dms.1_Missense_Mutation_p.E653Q|DDR1_uc003nru.2_Missense_Mutation_p.E635Q|DDR1_uc003nrv.2_Missense_Mutation_p.E678Q|DDR1_uc003nrw.1_Missense_Mutation_p.E407Q|DDR1_uc003nrz.1_5'UTR	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	672	Cytoplasmic (Potential).|Protein kinase.				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	TTTCCTGAAAGAGGTGAAGAT	0.587		NaN											0	0	0	0.010504	0	16	58									
MICA	4276	broad.mit.edu	37	6	31382788	31382788	+	Splice_Site	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:31382788G>A	uc003ntk.1	+	7	1064	c.1025_splice	c.e7-1							RecName: Full=MHC class I polypeptide-related sequence A;          Short=MIC-A; Flags: Precursor;												0		Ovarian(999;0.0253)				CTTTTCTCCAGAGCTCGTGAG	0.522		NaN											0	0	0	0.010729	0	9	73									
CSNK2B	1460	broad.mit.edu	37	6	31635728	31635728	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:31635728G>T	uc003nvr.1	+	3	496	c.156G>T	c.(154-156)ATG>ATT	p.M52I	BAT4_uc003nvn.2_5'Flank|BAT4_uc003nvo.3_5'Flank|BAT4_uc003nvp.3_5'Flank|BAT4_uc003nvq.2_5'Flank|CSNK2B_uc010jta.1_Missense_Mutation_p.M52I|CSNK2B_uc003nvs.1_Missense_Mutation_p.M52I|LY6G5B_uc003nvt.1_5'Flank	NM_001320	NP_001311	P67870	CSK2B_HUMAN	casein kinase 2, beta polypeptide	52					adiponectin-mediated signaling pathway|axon guidance|cellular protein complex assembly|negative regulation of cell proliferation|regulation of DNA binding|Wnt receptor signaling pathway	cytosol|nucleus|protein kinase CK2 complex	identical protein binding|protein domain specific binding|protein kinase regulator activity|receptor binding|transcription factor binding				0						CTCTAGACATGATCTTGGACC	0.458		NaN											1	0	0.00185496	0.001855	0.0019073	8	55									
BAT5	7920	broad.mit.edu	37	6	31657862	31657862	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:31657862C>T	uc003nvy.1	-	11	980	c.950G>A	c.(949-951)GGA>GAA	p.G317E	BAT5_uc003nvx.1_Missense_Mutation_p.G98E|BAT5_uc011dny.1_Missense_Mutation_p.G284E|BAT5_uc003nvz.1_Missense_Mutation_p.G98E|BAT5_uc011dnz.1_Missense_Mutation_p.G98E|BAT5_uc010jtc.1_RNA	NM_021160	NP_066983	O95870	ABHGA_HUMAN	HLA-B associated transcript 5	317						integral to membrane	hydrolase activity|protein binding				0						CACCGTGCTTCCAGCAAAGCC	0.542		NaN											0	0	0	0.013537	0	8	59									
PTK7	5754	broad.mit.edu	37	6	43096807	43096807	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:43096807C>G	uc003oub.1	+	2	370	c.172C>G	c.(172-174)CCG>GCG	p.P58A	PTK7_uc003ouc.1_Missense_Mutation_p.P58A|PTK7_uc003oud.1_Missense_Mutation_p.P58A|PTK7_uc003oue.1_Missense_Mutation_p.P58A|PTK7_uc003ouf.1_RNA|PTK7_uc003oug.1_RNA|PTK7_uc011dve.1_Missense_Mutation_p.P66A|PTK7_uc003oua.2_Missense_Mutation_p.P58A	NM_002821	NP_002812	Q13308	PTK7_HUMAN	PTK7 protein tyrosine kinase 7 isoform a	58	Ig-like C2-type 1.|Extracellular (Potential).				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			ovary(2)|large_intestine(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			GGTTGAGGCTCCGGGCCCGGT	0.642		NaN											0	0	0	0.004007	0	11	16									
XPO5	57510	broad.mit.edu	37	6	43516011	43516011	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:43516011G>A	uc003ovp.2	-	18	2258	c.2047C>T	c.(2047-2049)CAA>TAA	p.Q683*		NM_020750	NP_065801	Q9HAV4	XPO5_HUMAN	exportin 5	683					gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			skin(2)|breast(1)|kidney(1)	4	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			TGCATGTCTTGAGAAAGCCAG	0.502		NaN											0	0	0	0.005443	0	22	94									
OPN5	221391	broad.mit.edu	37	6	47775996	47775996	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:47775996C>T	uc003ozc.2	+	5	868	c.863C>T	c.(862-864)TCT>TTT	p.S288F	OPN5_uc003ozd.2_Missense_Mutation_p.S123F	NM_181744	NP_859528	Q6U736	OPN5_HUMAN	opsin 5 isoform 1	288	Extracellular (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to membrane	G-protein coupled receptor activity|photoreceptor activity			ovary(1)	1						ATACAGCTCTCTGTGGTGCCA	0.453		NaN											0	0	0	0.009535	0	25	130									
PHF3	23469	broad.mit.edu	37	6	64390047	64390047	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:64390047C>T	uc003pep.1	+	2	417	c.391C>T	c.(391-393)CGT>TGT	p.R131C	PHF3_uc010kaf.1_Missense_Mutation_p.R131C|PHF3_uc003pem.2_Missense_Mutation_p.R84C|PHF3_uc010kag.1_Missense_Mutation_p.R43C|PHF3_uc010kah.1_Intron|PHF3_uc003pen.2_Missense_Mutation_p.R43C|PHF3_uc011dxs.1_5'UTR|PHF3_uc003peo.2_Missense_Mutation_p.R131C	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	131					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			AAAATCACCTCGTTTAATGGC	0.383		NaN											0	0	0	0.012319	0	18	93									
IBTK	25998	broad.mit.edu	37	6	82927697	82927697	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:82927697C>G	uc003pjl.1	-	10	1933	c.1406G>C	c.(1405-1407)AGA>ACA	p.R469T	IBTK_uc011dyv.1_Missense_Mutation_p.R469T|IBTK_uc011dyw.1_Missense_Mutation_p.R469T|IBTK_uc010kbi.1_Missense_Mutation_p.R163T|IBTK_uc003pjm.2_Missense_Mutation_p.R469T	NM_015525	NP_056340	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton's tyrosine kinase	469					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		AGAACTCTTTCTTTTCTCTTC	0.318		NaN											0	0	0	0.008291	0	9	29									
SLC35F1	222553	broad.mit.edu	37	6	118588187	118588187	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:118588187G>A	uc003pxx.3	+	4	708	c.507G>A	c.(505-507)GTG>GTA	p.V169V	SLC35F1_uc003pxy.1_5'UTR	NM_001029858	NP_001025029	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	169	Helical; (Potential).				transport	integral to membrane				breast(1)	1				GBM - Glioblastoma multiforme(226;0.217)		TCCCAGTCGTGATTTTGCTCT	0.502		NaN											0	0	0	0.01441	0	56	332									
MYB	4602	broad.mit.edu	37	6	135511379	135511379	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:135511379G>C	uc003qfc.2	+	5	620	c.421G>C	c.(421-423)GAA>CAA	p.E141Q	MYB_uc003qfh.2_Missense_Mutation_p.E141Q|MYB_uc003qfi.2_Missense_Mutation_p.E141Q|MYB_uc010kgi.2_Missense_Mutation_p.E141Q|MYB_uc003qfq.2_Missense_Mutation_p.E141Q|MYB_uc010kgj.2_Missense_Mutation_p.E141Q|MYB_uc003qfo.2_Missense_Mutation_p.E141Q|MYB_uc003qfu.2_Missense_Mutation_p.E141Q|MYB_uc003qfl.2_RNA|MYB_uc003qfv.2_RNA|MYB_uc003qfz.2_RNA|MYB_uc003qfx.2_RNA|MYB_uc003qga.2_RNA|MYB_uc003qgb.2_RNA|MYB_uc010kgk.2_RNA|MYB_uc003qfd.2_RNA|MYB_uc003qfe.2_RNA|MYB_uc003qfg.2_RNA|MYB_uc003qff.2_RNA|MYB_uc003qfj.2_RNA|MYB_uc003qfm.2_RNA|MYB_uc003qfp.2_RNA|MYB_uc003qfn.2_RNA|MYB_uc003qfk.2_RNA|MYB_uc003qfr.2_RNA|MYB_uc003qfs.2_Intron|MYB_uc003qft.2_RNA|MYB_uc003qfw.2_Intron|MYB_uc003qfy.2_RNA|MYB_uc003qgc.2_RNA|MYB_uc003qfb.1_Missense_Mutation_p.E141Q|MYB_uc003qgd.1_5'UTR	NM_005375	NP_005366	P10242	MYB_HUMAN	v-myb myeloblastosis viral oncogene homolog	141	HTH myb-type 2.|Interaction with HIPK2 and NLK (By similarity).				blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			lung(1)	1	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)		CTTGAATCCAGAAGTTAAGAA	0.453		NaN	T	NFIB	adenoid cystic carcinoma								0	0	0	0.006214	0	9	53									
MYB	4602	broad.mit.edu	37	6	135539063	135539063	+	Missense_Mutation	SNP	C	C	T	rs148508251		TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:135539063C>T	uc003qfc.2	+	15	2067	c.1868C>T	c.(1867-1869)TCC>TTC	p.S623F	MYB_uc003qfh.2_Missense_Mutation_p.S744F|MYB_uc003qfi.2_Missense_Mutation_p.S728F|MYB_uc010kgi.2_Missense_Mutation_p.S586F|MYB_uc003qfq.2_Missense_Mutation_p.S741F|MYB_uc010kgj.2_Missense_Mutation_p.S588F|MYB_uc003qfo.2_Missense_Mutation_p.S538F|MYB_uc003qfu.2_Missense_Mutation_p.S620F|MYB_uc003qfl.2_RNA|MYB_uc003qfv.2_RNA|MYB_uc003qfz.2_RNA|MYB_uc003qfx.2_RNA|MYB_uc003qga.2_RNA|MYB_uc003qgb.2_RNA|MYB_uc010kgk.2_RNA|MYB_uc003qfd.2_RNA|MYB_uc003qfe.2_RNA|MYB_uc003qfg.2_RNA|MYB_uc003qff.2_RNA|MYB_uc003qfj.2_RNA|MYB_uc003qfm.2_RNA|MYB_uc003qfp.2_RNA|MYB_uc003qfn.2_RNA|MYB_uc003qfk.2_RNA|MYB_uc003qfr.2_RNA|MYB_uc003qfs.2_Missense_Mutation_p.S249F|MYB_uc003qft.2_RNA|MYB_uc003qfw.2_Missense_Mutation_p.S435F|MYB_uc003qfy.2_RNA|MYB_uc003qgc.2_RNA	NM_005375	NP_005366	P10242	MYB_HUMAN	v-myb myeloblastosis viral oncogene homolog	623					blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			lung(1)	1	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)		ATGACATCTTCCAGTCAAGCT	0.478		NaN	T	NFIB	adenoid cystic carcinoma								0	0	0	0.008291	0	10	69									
SYNE1	23345	broad.mit.edu	37	6	152631862	152631862	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:152631862C>G	uc010kiw.2	-	88	17459	c.16857G>C	c.(16855-16857)ATG>ATC	p.M5619I	SYNE1_uc010kiv.2_Missense_Mutation_p.M143I|SYNE1_uc003qos.3_Missense_Mutation_p.M143I|SYNE1_uc003qot.3_Missense_Mutation_p.M5548I|SYNE1_uc003qou.3_Missense_Mutation_p.M5619I	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5619	Spectrin 17.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GAATTTTGATCATCTGTCGCA	0.363		NaN								HNSCC(10;0.0054)			0	0	0	0.007413	0	15	23									
SYNE1	23345	broad.mit.edu	37	6	152740829	152740829	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:152740829C>G	uc010kiw.2	-	40	5898	c.5296G>C	c.(5296-5298)GAA>CAA	p.E1766Q	SYNE1_uc003qot.3_Missense_Mutation_p.E1773Q|SYNE1_uc003qou.3_Missense_Mutation_p.E1766Q|SYNE1_uc010kjb.1_Missense_Mutation_p.E1749Q	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1766	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGCTGGTGTTCAGCAACCACA	0.348		NaN								HNSCC(10;0.0054)			0	0	0	0.00499	0	11	42									
MAP3K4	4216	broad.mit.edu	37	6	161527697	161527697	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr6:161527697G>C	uc003qtn.2	+	20	4150	c.4008G>C	c.(4006-4008)TTG>TTC	p.L1336F	MAP3K4_uc010kkc.1_Missense_Mutation_p.L1332F|MAP3K4_uc003qto.2_Missense_Mutation_p.L1286F|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_Missense_Mutation_p.L789F|MAP3K4_uc003qtp.2_Missense_Mutation_p.L272F|MAP3K4_uc003qtq.2_Missense_Mutation_p.L25F	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	1336					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		ACGTTGGCTTGAGGAAGGTGA	0.378		NaN											0	0	0	0.01441	0	38	50									
C7orf27	221927	broad.mit.edu	37	7	2579517	2579517	+	Silent	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:2579517C>G	uc003smi.2	-	11	1443	c.1401G>C	c.(1399-1401)CTG>CTC	p.L467L	C7orf27_uc003smh.3_5'UTR	NM_152743	NP_689956	Q6PJG6	BRAT1_HUMAN	hypothetical protein LOC221927 precursor	467					response to ionizing radiation	nucleus	protein binding				0		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;2.91e-14)		AGGCCTTCTTCAGAACCTGGA	0.652		NaN											0	0	0	0.001168	0	4	5									
EIF2AK1	27102	broad.mit.edu	37	7	6098634	6098634	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:6098634G>C	uc003spp.2	-	1	227	c.81C>G	c.(79-81)ATC>ATG	p.I27M	EIF2AK1_uc003spq.2_Missense_Mutation_p.I27M|EIF2AK1_uc011jwm.1_Translation_Start_Site	NM_014413	NP_055228	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha	27				PPAIDFPAE -> RRHRLSRR (in Ref. 1; AAF70289).	negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			upper_aerodigestive_tract(1)|stomach(1)|lung(1)|central_nervous_system(1)	4		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		CGGGAAAGTCGATGGCCGGCG	0.642		NaN											0	0	0	0.009096	0	3	6									
MPP6	51678	broad.mit.edu	37	7	24705264	24705264	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:24705264G>C	uc003swx.2	+	8	1140	c.841G>C	c.(841-843)GAG>CAG	p.E281Q	MPP6_uc003swy.2_Missense_Mutation_p.E281Q|MPP6_uc010kur.2_5'Flank	NM_016447	NP_057531	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6	281	SH3.				protein complex assembly		protein binding				0						GTTCCTGGAAGAGAAGAGAAA	0.423		NaN											0	0	0	0.003163	0	12	64									
CREB5	9586	broad.mit.edu	37	7	28534602	28534602	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:28534602G>C	uc003szq.2	+	3	544	c.154G>C	c.(154-156)GAC>CAC	p.D52H	CREB5_uc003szo.2_Missense_Mutation_p.D19H|CREB5_uc003szr.2_Missense_Mutation_p.D45H	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	52					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						AATAAAAACAGACAATATGTT	0.408		NaN											0	0	0	0.003954	0	23	42									
PLEKHA8	84725	broad.mit.edu	37	7	30102287	30102287	+	Splice_Site	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:30102287G>C	uc003tam.1	+	12	1321	c.1230_splice	c.e12-1	p.R410_splice	PLEKHA8_uc003tao.2_Splice_Site_p.R294_splice|PLEKHA8_uc003tap.1_Splice_Site_p.R410_splice|PLEKHA8_uc003tan.2_Splice_Site_p.R410_splice	NM_032639	NP_116028	Q96JA3	PKHA8_HUMAN	pleckstrin homology domain containing, family A						protein transport	cytoplasm	glycolipid binding|glycolipid transporter activity			breast(3)|ovary(1)	4						TTTTGTTTTAGAGGTCTCAAA	0.328		NaN											0	0	0	0.013537	0	11	39									
BBS9	27241	broad.mit.edu	37	7	33185904	33185904	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:33185904C>G	uc003tdn.1	+	2	553	c.40C>G	c.(40-42)CTG>GTG	p.L14V	BBS9_uc003tdo.1_Missense_Mutation_p.L14V|BBS9_uc003tdp.1_Missense_Mutation_p.L14V|BBS9_uc003tdq.1_Missense_Mutation_p.L14V|BBS9_uc010kwn.1_RNA|BBS9_uc011kan.1_Missense_Mutation_p.L14V	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	14					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			GTCTACTATTCTGGGAGATAA	0.333		NaN							Bardet-Biedl_syndrome				0	0	0	0.009718	0	36	100									
ADCY1	107	broad.mit.edu	37	7	45743204	45743204	+	Silent	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:45743204C>G	uc003tne.3	+	16	2595	c.2577C>G	c.(2575-2577)CTC>CTG	p.L859L		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	859	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TCCAGGACCTCTACTACCAGT	0.582		NaN											0	0	0	0.003954	0	24	70									
ZNF479	90827	broad.mit.edu	37	7	57188109	57188109	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:57188109G>A	uc010kzo.2	-	5	1284	c.1013C>T	c.(1012-1014)TCA>TTA	p.S338L		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	338	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			AGTAAGGTTTGAGGACCAGCT	0.453		NaN											0	0	0	0.004007	0	10	42									
HGF	3082	broad.mit.edu	37	7	81346648	81346648	+	Silent	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:81346648C>G	uc003uhl.2	-	11	1470	c.1305G>C	c.(1303-1305)CTG>CTC	p.L435L	HGF_uc003uhm.2_Silent_p.L430L	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	435	Kringle 4.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						AATTCTCATTCAGCTTACTTG	0.438		NaN											0	0	0	0.01441	0	43	87									
PEX1	5189	broad.mit.edu	37	7	92143172	92143172	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:92143172C>G	uc003uly.2	-	6	1445	c.1349G>C	c.(1348-1350)AGA>ACA	p.R450T	PEX1_uc011khr.1_Missense_Mutation_p.R242T|PEX1_uc010ley.2_Missense_Mutation_p.R450T|PEX1_uc011khs.1_Missense_Mutation_p.R128T|PEX1_uc011kht.1_RNA	NM_000466	NP_000457	O43933	PEX1_HUMAN	peroxin1	450					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)|central_nervous_system(1)	2	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TAAATTCTCTCTAGGTTGTAA	0.328		NaN											0	0	0	0.013726	0	29	77									
ZNF394	84124	broad.mit.edu	37	7	99091818	99091818	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:99091818G>T	uc003uqs.2	-	3	1181	c.1020C>A	c.(1018-1020)TTC>TTA	p.F340L	ZNF394_uc003uqt.2_Missense_Mutation_p.F133L	NM_032164	NP_115540	Q53GI3	ZN394_HUMAN	zinc finger protein 394	340					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					TGGAATGATGGAAACTGTCTC	0.483		NaN											1	0	9.78485e-24	0.013726	1.13186e-23	31	88									
MUC17	140453	broad.mit.edu	37	7	100679360	100679360	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:100679360C>G	uc003uxp.1	+	3	4716	c.4663C>G	c.(4663-4665)CCT>GCT	p.P1555A	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1555	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|24.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CAGTTCATCTCCTACAACTGC	0.493		NaN											0	0	0	0.01441	0	70	437									
MUC17	140453	broad.mit.edu	37	7	100679868	100679868	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:100679868C>G	uc003uxp.1	+	3	5224	c.5171C>G	c.(5170-5172)TCT>TGT	p.S1724C	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1724	Extracellular (Potential).|59 X approximate tandem repeats.|27.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GTGACCACTTCTACTGAAGCC	0.478		NaN											0	0	0	0.01441	0	79	512									
CUX1	1523	broad.mit.edu	37	7	101923386	101923386	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:101923386G>C	uc003uyt.2	+	19	1757	c.1738G>C	c.(1738-1740)GAC>CAC	p.D580H	CUX1_uc011kkn.1_Missense_Mutation_p.D541H|CUX1_uc003uyw.2_Missense_Mutation_p.D534H|CUX1_uc003uyv.2_Missense_Mutation_p.D564H|CUX1_uc003uyu.2_Missense_Mutation_p.D578H|CUX1_uc003uyz.2_RNA	NM_001913	NP_001904	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform b	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						GGAGCGCCTGGACCCCTTCTC	0.662		NaN											0	0	0	0.004656	0	22	56									
KCND2	3751	broad.mit.edu	37	7	120385895	120385895	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:120385895A>G	uc003vjj.1	+	5	2494	c.1529A>G	c.(1528-1530)AAT>AGT	p.N510S		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	510	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					GCAACTGTTAATCGTCCTTCA	0.438		NaN											0	0	0	0.008361	0	27	51									
TSGA13	114960	broad.mit.edu	37	7	130353957	130353957	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:130353957G>T	uc003vqi.2	-	8	1182	c.725C>A	c.(724-726)TCG>TAG	p.S242*	COPG2_uc003vqh.1_5'Flank|TSGA13_uc003vqj.2_Nonsense_Mutation_p.S242*	NM_052933	NP_443165	Q96PP4	TSG13_HUMAN	testis specific, 13	242										ovary(2)	2	Melanoma(18;0.0435)					TTCCAAGAGCGATGCGAGTGT	0.582		NaN											1	0	3.86903e-22	0.013726	4.46662e-22	32	72									
TBXAS1	6916	broad.mit.edu	37	7	139706905	139706905	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:139706905C>G	uc011kqv.1	+	11	1454	c.1290C>G	c.(1288-1290)TTC>TTG	p.F430L	TBXAS1_uc003vvh.2_Missense_Mutation_p.F384L|TBXAS1_uc010lne.2_Missense_Mutation_p.F316L|TBXAS1_uc011kqu.1_Missense_Mutation_p.F335L|TBXAS1_uc003vvi.2_Missense_Mutation_p.F384L|TBXAS1_uc003vvj.2_Missense_Mutation_p.F384L|TBXAS1_uc011kqw.1_Missense_Mutation_p.F364L	NM_001130966	NP_001124438	P24557	THAS_HUMAN	thromboxane A synthase 1, platelet isoform	383	Cytoplasmic (Potential).				hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			ovary(2)|breast(1)	3	Melanoma(164;0.0142)					CCCCTGAGTTCTGCAGCCTCG	0.532		NaN											0	0	0	0.01441	0	60	133									
OR2A25	392138	broad.mit.edu	37	7	143771967	143771967	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:143771967C>T	uc011ktx.1	+	1	655	c.655C>T	c.(655-657)CAT>TAT	p.H219Y		NM_001004488	NP_001004488	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A,	219	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					ATCTTATGTTCATATTCTATG	0.483		NaN											0	0	0	0.003954	0	25	60									
ZNF777	27153	broad.mit.edu	37	7	149129883	149129883	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:149129883C>G	uc003wfv.2	-	6	1643	c.1480G>C	c.(1480-1482)GAG>CAG	p.E494Q		NM_015694	NP_056509	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	494					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			GGGGACATCTCCCCGGGCAGC	0.602		NaN											0	0	0	0.004482	0	7	27									
MLL3	58508	broad.mit.edu	37	7	151945439	151945439	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:151945439G>A	uc003wla.2	-	14	2299	c.2080C>T	c.(2080-2082)CTT>TTT	p.L694F		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	694					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TCTAGTGGAAGAGTGACAGAT	0.423		NaN	N		medulloblastoma								0	0	0	0.000602	0	5	40									
DOK2	9046	broad.mit.edu	37	8	21767094	21767094	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr8:21767094G>C	uc003wzy.1	-	5	1060	c.967C>G	c.(967-969)CAG>GAG	p.Q323E	DOK2_uc003wzx.1_Missense_Mutation_p.Q323E|DOK2_uc003wzz.1_Missense_Mutation_p.Q169E|DOK2_uc010lth.1_Missense_Mutation_p.Q169E	NM_003974	NP_003965	O60496	DOK2_HUMAN	docking protein 2	323	Pro-rich.				blood coagulation|leukocyte migration	cytosol	identical protein binding|insulin receptor binding				0				Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		GCCAGGAGCTGAGGAGGGACT	0.647		NaN											0	0	0	0.012213	0	30	43									
PEBP4	157310	broad.mit.edu	37	8	22570973	22570973	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr8:22570973C>G	uc003xcn.1	-	7	686	c.594G>C	c.(592-594)CAG>CAC	p.Q198H		NM_144962	NP_659399	Q96S96	PEBP4_HUMAN	phosphatidylethanolamine-binding protein 4	198						lysosome				ovary(1)|large_intestine(1)|breast(1)|skin(1)	4		Prostate(55;0.0453)|Breast(100;0.103)		Colorectal(74;0.0434)|COAD - Colon adenocarcinoma(73;0.124)		CCTGGTAGTTCTGGGTCATGA	0.557		NaN											0	0	0	0.00308	0	8	18									
PUF60	22827	broad.mit.edu	37	8	144899273	144899273	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr8:144899273G>A	uc003yzs.2	-	11	1251	c.1187C>T	c.(1186-1188)TCG>TTG	p.S396L	SCRIB_uc003yzo.1_5'Flank|SCRIB_uc003yzp.1_5'Flank|PUF60_uc003yzr.2_Missense_Mutation_p.S336L|PUF60_uc003yzt.2_Missense_Mutation_p.S379L|PUF60_uc003yzq.2_Missense_Mutation_p.S353L|PUF60_uc003yzu.1_Missense_Mutation_p.S385L	NM_078480	NP_510965	Q9UHX1	PUF60_HUMAN	poly-U binding splicing factor 60KDa isoform a	396	Inhibits homodimerization.|Inhibits transcriptional repression, interaction with ERCC3 and apoptosis induction.				apoptosis|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleus|ribonucleoprotein complex	DNA binding|nucleotide binding|protein binding|RNA binding				0	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CACTCCCACCGAGGGGATGGT	0.612		NaN											0	0	0	0.00308	0	5	32									
NRBP2	340371	broad.mit.edu	37	8	144921499	144921499	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr8:144921499G>C	uc011lkt.1	-	6	707	c.567C>G	c.(565-567)ATC>ATG	p.I189M	NRBP2_uc003yzv.2_Translation_Start_Site|NRBP2_uc003yzz.1_5'Flank|NRBP2_uc003yzw.2_5'Flank|NRBP2_uc010mfl.2_5'Flank|NRBP2_uc010mfm.2_Translation_Start_Site|NRBP2_uc011lks.1_Translation_Start_Site|NRBP2_uc003yzy.2_Translation_Start_Site	NM_178564	NP_848659	Q9NSY0	NRBP2_HUMAN	nuclear receptor binding protein 2	189	Protein kinase.				negative regulation of neuron apoptosis|neuron differentiation	cytoplasm	ATP binding|protein kinase activity			central_nervous_system(2)	2	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			AGCCGATCTTGATGAGGCCGT	0.657		NaN											0	0	0	0.009096	0	3	28									
PLEC	5339	broad.mit.edu	37	8	144999683	144999683	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr8:144999683C>T	uc003zaf.1	-	31	4995	c.4825G>A	c.(4825-4827)GAG>AAG	p.E1609K	PLEC_uc003zab.1_Missense_Mutation_p.E1472K|PLEC_uc003zac.1_Missense_Mutation_p.E1476K|PLEC_uc003zad.2_Missense_Mutation_p.E1472K|PLEC_uc003zae.1_Missense_Mutation_p.E1440K|PLEC_uc003zag.1_Missense_Mutation_p.E1450K|PLEC_uc003zah.2_Missense_Mutation_p.E1458K|PLEC_uc003zaj.2_Missense_Mutation_p.E1499K	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	1609	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						AGCTCCCCCTCAGCCCCGCCA	0.721		NaN											0	0	0	0.001168	0	5	25									
HSF1	3297	broad.mit.edu	37	8	145533476	145533476	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr8:145533476G>A	uc003zbt.3	+	4	552	c.382G>A	c.(382-384)GAA>AAA	p.E128K	HSF1_uc003zbu.3_RNA	NM_005526	NP_005517	Q00613	HSF1_HUMAN	heat shock transcription factor 1	128						cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;1.12e-39)|all cancers(56;9.11e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0547)|Colorectal(110;0.055)			CCTGAAGAGTGAAGACATAAA	0.602		NaN											0	0	0	0.00278	0	16	152									
GLDC	2731	broad.mit.edu	37	9	6540106	6540106	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:6540106G>C	uc003zkc.2	-	22	2803	c.2610C>G	c.(2608-2610)TTC>TTG	p.F870L		NM_000170	NP_000161	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	870					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CAGACTTTTTGAAGGGTCTCG	0.448		NaN											0	0	0	0.010504	0	19	90									
C9orf93	203238	broad.mit.edu	37	9	15623317	15623317	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:15623317C>G	uc003zmd.2	+	7	1043	c.728C>G	c.(727-729)ACA>AGA	p.T243R	C9orf93_uc010mih.1_Missense_Mutation_p.T243R|C9orf93_uc003zme.2_Missense_Mutation_p.T150R|C9orf93_uc011lmu.1_Missense_Mutation_p.T243R|C9orf93_uc003zmc.2_Missense_Mutation_p.T243R	NM_173550	NP_775821	Q6TFL3	CI093_HUMAN	hypothetical protein LOC203238	243	Potential.|Glu-rich.										0				GBM - Glioblastoma multiforme(50;4.84e-07)		AAATTAGAAACAGAACATATG	0.348		NaN											0	0	0	0.006122	0	15	72									
SLC24A2	25769	broad.mit.edu	37	9	19521029	19521029	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:19521029C>G	uc003zoa.1	-	9	1661	c.1599G>C	c.(1597-1599)GAG>GAC	p.E533D	SLC24A2_uc003zob.1_Missense_Mutation_p.E516D	NM_020344	NP_065077	Q9UI40	NCKX2_HUMAN	solute carrier family 24	533	Cytoplasmic (Potential).				visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(3)	3				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		GGCCCATAATCTCTTCACTGA	0.448		NaN											0	0	0	0.007413	0	14	17									
ALDH1A1	216	broad.mit.edu	37	9	75540481	75540481	+	Silent	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:75540481C>G	uc004ajd.2	-	6	605	c.552G>C	c.(550-552)CTG>CTC	p.L184L	ALDH1A1_uc011lsh.1_Silent_p.L105L|ALDH1A1_uc011lsg.1_Silent_p.L10L	NM_000689	NP_000680	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1A1	184					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity			ovary(3)|lung(1)	4					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TTCCACAGCTCAGTGCAGGCC	0.423		NaN											0	0	0	0.004656	0	24	30									
PRUNE2	158471	broad.mit.edu	37	9	79318656	79318656	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:79318656C>T	uc010mpk.2	-	9	7997	c.7873G>A	c.(7873-7875)GAA>AAA	p.E2625K	PRUNE2_uc004akj.3_Missense_Mutation_p.E78K|PRUNE2_uc010mpl.1_Missense_Mutation_p.E78K	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	2625					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						GCAGGGCTTTCAAAAGATGAT	0.493		NaN											0	0	0	0.004672	0	3	9									
S1PR3	1903	broad.mit.edu	37	9	91617099	91617099	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:91617099C>T	uc004aqe.2	+	2	1380	c.984C>T	c.(982-984)ATC>ATT	p.I328I		NM_005226	NP_005217	Q99500	S1PR3_HUMAN	sphingosine-1-phosphate receptor 3	328	Cytoplasmic (By similarity).				anatomical structure morphogenesis|elevation of cytosolic calcium ion concentration|inflammatory response|positive regulation of cell proliferation	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)|central_nervous_system(1)|skin(1)	5						CCTCACCCATCCAGCCTGCGC	0.627		NaN											0	0	0	0.012319	0	18	27									
FAM129B	64855	broad.mit.edu	37	9	130269539	130269539	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:130269539G>A	uc004brh.2	-	14	2028	c.1826C>T	c.(1825-1827)TCA>TTA	p.S609L	FAM129B_uc004bri.2_Missense_Mutation_p.S596L|FAM129B_uc004brj.3_3'UTR	NM_022833	NP_073744	Q96TA1	NIBL1_HUMAN	hypothetical protein LOC64855 isoform 1	609							protein binding				0						GAGGGTGGCTGACTCCGGGGT	0.697		NaN											0	0	0	0.006122	0	15	12									
GOLGA2	2801	broad.mit.edu	37	9	131028091	131028091	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:131028091G>A	uc011maw.1	-	10	734	c.721C>T	c.(721-723)CAG>TAG	p.Q241*	GOLGA2_uc010mxw.2_Intron|GOLGA2_uc004bul.1_Nonsense_Mutation_p.Q142*|GOLGA2_uc004bum.1_Nonsense_Mutation_p.Q115*	NM_004486	NP_004477	Q08379	GOGA2_HUMAN	Golgi autoantigen, golgin subfamily a, 2	241	Potential.					Golgi cisterna membrane	protein binding			ovary(1)	1						GCAGCATGCTGAGTGTGAGCC	0.532		NaN											0	0	0	0.007291	0	22	54									
KCNT1	57582	broad.mit.edu	37	9	138650273	138650273	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:138650273G>A	uc011mdq.1	+	10	847	c.773G>A	c.(772-774)CGT>CAT	p.R258H	KCNT1_uc011mdr.1_Missense_Mutation_p.R85H|KCNT1_uc010nbf.2_Missense_Mutation_p.R210H|KCNT1_uc004cgo.1_Missense_Mutation_p.R7H	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	258						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		GACTTCCACCGTGCCATCCTG	0.587		NaN											0	0	0	0.014323	0	17	81									
INPP5E	56623	broad.mit.edu	37	9	139326391	139326391	+	Silent	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:139326391G>A	uc004cho.2	-	7	1819	c.1434C>T	c.(1432-1434)TTC>TTT	p.F478F	INPP5E_uc010nbm.2_Silent_p.F477F	NM_019892	NP_063945	Q9NRR6	INP5E_HUMAN	inositol polyphosphate-5-phosphatase E	478						cilium axoneme|cytoskeleton|Golgi cisterna membrane	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity			skin(1)	1		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.36e-06)|Epithelial(140;1.4e-05)		GGCGGAAGTTGAAGTCTCCAA	0.667		NaN											0	0	0	0.008361	0	22	23									
GRIN1	2902	broad.mit.edu	37	9	140051206	140051206	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:140051206G>A	uc004clk.2	+	5	1087	c.757G>A	c.(757-759)GAG>AAG	p.E253K	GRIN1_uc004cli.1_5'UTR|GRIN1_uc004clj.1_Missense_Mutation_p.E250K|GRIN1_uc004cll.2_Missense_Mutation_p.E253K|GRIN1_uc004clm.2_Missense_Mutation_p.E253K|GRIN1_uc004cln.2_Missense_Mutation_p.E271K|GRIN1_uc004clo.2_Missense_Mutation_p.E271K	NM_007327	NP_015566	Q05586	NMDZ1_HUMAN	NMDA receptor 1 isoform NR1-3 precursor	253	Extracellular (Potential).				ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			skin(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	CGGCGAGCGCGAGATCTCGGG	0.697		NaN											0	0	0	0.001984	0	6	3									
GRIN1	2902	broad.mit.edu	37	9	140051368	140051368	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:140051368G>A	uc004clk.2	+	6	1177	c.847G>A	c.(847-849)GAC>AAC	p.D283N	GRIN1_uc004cli.1_5'UTR|GRIN1_uc004clj.1_Missense_Mutation_p.D280N|GRIN1_uc004cll.2_Missense_Mutation_p.D283N|GRIN1_uc004clm.2_Missense_Mutation_p.D283N|GRIN1_uc004cln.2_Missense_Mutation_p.D301N|GRIN1_uc004clo.2_Missense_Mutation_p.D301N	NM_007327	NP_015566	Q05586	NMDZ1_HUMAN	NMDA receptor 1 isoform NR1-3 precursor	283	Extracellular (Potential).				ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			skin(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	CCACATCAGCGACGCCGTGGG	0.672		NaN											0	0	0	0.00308	0	7	3									
MRPL41	64975	broad.mit.edu	37	9	140446562	140446562	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:140446562G>A	uc004cnh.3	+	2	159	c.29G>A	c.(28-30)TGC>TAC	p.C10Y	PNPLA7_uc010ncj.1_5'Flank|PNPLA7_uc004cnf.2_5'Flank	NM_032477	NP_115866	Q8IXM3	RM41_HUMAN	mitochondrial ribosomal protein L41	10					apoptosis|cell cycle|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome				0	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000415)|Epithelial(140;0.00106)		GCGGCGCGCTGCCTGGTCCGG	0.657		NaN											0	0	0	0.006214	0	7	9									
EHMT1	79813	broad.mit.edu	37	9	140729270	140729270	+	Silent	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr9:140729270C>T	uc011mfc.1	+	27	3799	c.3762C>T	c.(3760-3762)TTC>TTT	p.F1254F	EHMT1_uc004coe.2_Silent_p.F159F	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	1254					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		GCAAGCTCTTCAGCTGCCGCT	0.672		NaN											0	0	0	0.00499	0	14	16									
STS	412	broad.mit.edu	37	X	7268167	7268167	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:7268167G>C	uc004cry.3	+	10	1862	c.1617G>C	c.(1615-1617)CAG>CAC	p.Q539H		NM_000351	NP_000342	P08842	STS_HUMAN	steryl-sulfatase precursor	539	Lumenal.				female pregnancy|steroid catabolic process	endoplasmic reticulum membrane|endosome|Golgi apparatus|integral to membrane|lysosome|microsome|plasma membrane	metal ion binding|steryl-sulfatase activity			central_nervous_system(1)	1		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)			Estrone(DB00655)	GACACACCCAGACCCTGCCAG	0.542		NaN							Ichthyosis				0	0	0	0.00632	0	21	14									
TLR8	51311	broad.mit.edu	37	X	12938248	12938248	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:12938248C>G	uc004cve.2	+	2	1157	c.1089C>G	c.(1087-1089)TTC>TTG	p.F363L	TLR8_uc004cvd.2_Missense_Mutation_p.F381L	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	363	Extracellular (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						CCAGAAACTTCTCTAAACTTT	0.393		NaN											0	0	0	0.007291	0	26	43									
TLR8	51311	broad.mit.edu	37	X	12938564	12938564	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:12938564C>G	uc004cve.2	+	2	1473	c.1405C>G	c.(1405-1407)CAT>GAT	p.H469D	TLR8_uc004cvd.2_Missense_Mutation_p.H487D	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	469	Extracellular (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						GAACTTTTATCATTTCACCCG	0.398		NaN											0	0	0	0.008361	0	22	38									
FIGF	2277	broad.mit.edu	37	X	15371214	15371214	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:15371214C>T	uc004cwt.1	-	5	1227	c.718G>A	c.(718-720)GAA>AAA	p.E240K		NM_004469	NP_004460	O43915	VEGFD_HUMAN	vascular endothelial growth factor D	240	4 X 16 AA repeats of C-X(10)-C-X-C- X(1,3)-C.				angiogenesis|cell differentiation|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of mast cell chemotaxis|vascular endothelial growth factor receptor signaling pathway	extracellular space|membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity|platelet-derived growth factor receptor binding			ovary(1)|breast(1)|central_nervous_system(1)	3	Hepatocellular(33;0.183)					AGTGGATTTTCCTCCTGCAAA	0.264		NaN											0	0	0	0.008871	0	14	35									
CXorf23	256643	broad.mit.edu	37	X	19973576	19973576	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:19973576C>G	uc004czp.2	-	4	1383	c.1383G>C	c.(1381-1383)CAG>CAC	p.Q461H	CXorf23_uc010nfn.2_RNA|CXorf23_uc011mjg.1_Missense_Mutation_p.Q26H|CXorf23_uc004czo.2_Missense_Mutation_p.Q411H	NM_198279	NP_938020	A2AJT9	CX023_HUMAN	hypothetical protein LOC256643	461						mitochondrion				lung(1)|skin(1)	2						TTTCAGTATTCTGAGTTGAGT	0.378		NaN											0	0	0	0.003163	0	12	29									
MAGEB1	4112	broad.mit.edu	37	X	30269617	30269617	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:30269617C>G	uc004dcc.2	+	4	1327	c.1007C>G	c.(1006-1008)TCT>TGT	p.S336C	MAGEB1_uc004dcd.2_Missense_Mutation_p.S336C|MAGEB1_uc004dce.2_Missense_Mutation_p.S336C	NM_002363	NP_002354	P43366	MAGB1_HUMAN	melanoma antigen family B, 1	336											0						AGAGCGCGTTCTAGAGCCCCA	0.507		NaN											0	0	0	0.00632	0	24	14									
PRICKLE3	4007	broad.mit.edu	37	X	49040229	49040229	+	Silent	SNP	C	C	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:49040229C>A	uc004dmy.1	-	3	296	c.270G>T	c.(268-270)TCG>TCT	p.S90S	PRICKLE3_uc011mmv.1_Silent_p.S22S|PRICKLE3_uc011mmw.1_Silent_p.S22S|PRICKLE3_uc011mmx.1_Silent_p.S90S|PRICKLE3_uc011mmy.1_Silent_p.S90S	NM_006150	NP_006141	O43900	PRIC3_HUMAN	LIM domain only 6	90	PET.						protein binding|zinc ion binding			breast(1)	1						CATACTCCTCCGATGCACAGC	0.617		NaN											1	0	4.74835e-14	0.010818	5.21335e-14	23	10									
PRICKLE3	4007	broad.mit.edu	37	X	49040246	49040246	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:49040246C>G	uc004dmy.1	-	3	279	c.253G>C	c.(253-255)GAC>CAC	p.D85H	PRICKLE3_uc011mmv.1_Missense_Mutation_p.D17H|PRICKLE3_uc011mmw.1_Missense_Mutation_p.D17H|PRICKLE3_uc011mmx.1_Missense_Mutation_p.D85H|PRICKLE3_uc011mmy.1_Missense_Mutation_p.D85H	NM_006150	NP_006141	O43900	PRIC3_HUMAN	LIM domain only 6	85	PET.						protein binding|zinc ion binding			breast(1)	1						CAGCCTGAGTCGTCGTCGGAG	0.642		NaN											0	0	0	0.00623	0	30	15									
FAM199X	139231	broad.mit.edu	37	X	103411483	103411483	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:103411483C>T	uc004elw.2	+	1	183	c.17C>T	c.(16-18)TCG>TTG	p.S6L		NM_207318	NP_997201	Q6PEV8	F199X_HUMAN	hypothetical protein LOC139231	6										ovary(1)	1						GACGAGGCCTCGGCCATCACT	0.701		NaN											0	0	0	0.001168	0	5	1									
RGAG1	57529	broad.mit.edu	37	X	109695851	109695851	+	Missense_Mutation	SNP	C	C	T	rs148619359		TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:109695851C>T	uc004eor.1	+	3	2252	c.2006C>T	c.(2005-2007)TCG>TTG	p.S669L	RGAG1_uc011msr.1_Missense_Mutation_p.S669L	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	669										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						TTGTCTGCATCGCTAATGAGA	0.512		NaN											0	0	0	0.00245	0	13	32									
FAM70A	55026	broad.mit.edu	37	X	119402108	119402108	+	Silent	SNP	A	A	G			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:119402108A>G	uc004eso.3	-	9	1109	c.882T>C	c.(880-882)TAT>TAC	p.Y294Y	FAM70A_uc004esp.3_Silent_p.Y270Y|FAM70A_uc010nqo.2_Silent_p.Y186Y	NM_017938	NP_060408	Q5JRV8	FA70A_HUMAN	hypothetical protein LOC55026 isoform 1	294	Pro-rich.					integral to membrane				lung(1)|breast(1)	2						CCTGAAAGTCATAAGCAGAAT	0.413		NaN											0	0	0	0.01441	0	75	45									
CETN2	1069	broad.mit.edu	37	X	151996453	151996453	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:151996453G>A	uc004fgq.2	-	5	498	c.451C>T	c.(451-453)CGA>TGA	p.R151*	CETN2_uc004fgr.2_Nonsense_Mutation_p.R80*	NM_004344	NP_004335	P41208	CETN2_HUMAN	caltractin	151	2.|EF-hand 4.				cell division|centriole replication|G2/M transition of mitotic cell cycle|mitosis|nucleotide-excision repair|regulation of cytokinesis	centriole|cytosol|XPC complex	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					TCTCCATCTCGATCAGCTTCA	0.358		NaN						Direct_reversal_of_damage|NER					0	0	0	0.007291	0	22	74									
NSDHL	50814	broad.mit.edu	37	X	152014895	152014895	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:152014895G>A	uc004fgt.1	+	3	288	c.27G>A	c.(25-27)ATG>ATA	p.M9I	NSDHL_uc004fgs.1_Missense_Mutation_p.M9I	NM_001129765	NP_001123237	Q15738	NSDHL_HUMAN	NAD(P) dependent steroid dehydrogenase-like	9					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity|sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity				0	Acute lymphoblastic leukemia(192;6.56e-05)				NADH(DB00157)	GCGAGCCAATGAGAGACCAAG	0.408		NaN											0	0	0	0.009718	0	31	33									
HCFC1	3054	broad.mit.edu	37	X	153229678	153229678	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrX:153229678G>C	uc004fjp.2	-	3	928	c.400C>G	c.(400-402)CCG>GCG	p.P134A		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	134	Kelch 2.			P->S: Eliminates VIC formation and association with VP16. Weak association with POU2F1. Unable to associate with CREBZF and BAP1. Unable to rescue proliferation in temperature-sensitive arrested cells.	cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CGAGGACACGGAGGGGGCCCG	0.562		NaN											0	0	0	0.01441	0	56	38									
USP9Y	8287	broad.mit.edu	37	Y	14898191	14898191	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chrY:14898191G>T	uc004fst.1	+	23	4151	c.3206G>T	c.(3205-3207)GGA>GTA	p.G1069V	USP9Y_uc010nwu.1_RNA	NM_004654	NP_004645	O00507	USP9Y_HUMAN	ubiquitin specific protease 9, Y-linked	1069					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0						GCAAAACTTGGAGAAGGCAAA	0.398		NaN											1	0	1.02788e-11	0.00499	1.10564e-11	14	51									
RPTN	126638	broad.mit.edu	37	1	152128385	152128388	+	Frame_Shift_Del	DEL	TGTC	TGTC	-			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr1:152128385_152128388delTGTC	uc001ezs.1	-	3	1252_1255	c.1187_1190delGACA	c.(1186-1191)AGACAAfs	p.R396fs		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	396_397	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						ACTTTGGTCTTGTCTGTCTGTCTG	0.505		NaN											NaN	NaN	NaN	NaN	NaN	8	1501	---	---							
SUPT5H	6829	broad.mit.edu	37	19	39962359	39962359	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr19:39962359delG	uc002olo.3	+	20	2118	c.1939delG	c.(1939-1941)GGGfs	p.G647fs	SUPT5H_uc002olp.3_Frame_Shift_Del_p.G647fs|SUPT5H_uc002olq.3_Frame_Shift_Del_p.G643fs|SUPT5H_uc002oln.3_Frame_Shift_Del_p.G647fs|SUPT5H_uc002olr.3_Frame_Shift_Del_p.G647fs|SUPT5H_uc002ols.1_Frame_Shift_Del_p.G270fs|SUPT5H_uc010egp.1_Frame_Shift_Del_p.G13fs	NM_001111020	NP_001104490	O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog isoform a	647					cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			ovary(3)|pancreas(1)	4	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGTGCTGGCTGGGGGCTCAAA	0.587		NaN											NaN	NaN	NaN	NaN	NaN	15	40	---	---							
USP4	7375	broad.mit.edu	37	3	49362440	49362441	+	Frame_Shift_Ins	INS	-	-	A			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr3:49362440_49362441insA	uc003cwq.2	-	5	598_599	c.519_520insT	c.(517-522)TTCAACfs	p.F173fs	USP4_uc003cwr.2_Frame_Shift_Ins_p.F173fs	NM_003363	NP_003354	Q13107	UBP4_HUMAN	ubiquitin specific protease 4 isoform a	173_174					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		GCAGGGATGTTGAATAGCTTCC	0.5		NaN											NaN	NaN	NaN	NaN	NaN	52	162	---	---							
PAXIP1	22976	broad.mit.edu	37	7	154760267	154760269	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-DK-A3IT-01A-31D-A20D-08	TCGA-DK-A3IT-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07db4596-cb49-4a32-bc99-3b202ffe61a2	1b67f5e5-90c0-4726-a5bd-ee1fd31d56cd	g.chr7:154760267_154760269delCTG	uc003wlp.2	-	7	1685_1687	c.1642_1644delCAG	c.(1642-1644)CAGdel	p.Q548del	PAXIP1_uc003wlq.1_In_Frame_Del_p.Q514del|PAXIP1_uc011kvs.1_In_Frame_Del_p.Q512del|PAXIP1_uc003wlr.1_In_Frame_Del_p.Q457del	NM_007349	NP_031375	Q6ZW49	PAXI1_HUMAN	PAX interacting protein 1	548	Gln-rich.				DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)		GACTTTGCATctgctgctgctgc	0.227		NaN											NaN	NaN	NaN	NaN	NaN	4	4	---	---							
