Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
SAMD11	148398	broad.mit.edu	37	1	878746	878746	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:878746G>C	uc001abw.1	+	12	1758	c.1678G>C	c.(1678-1680)GAG>CAG	p.E560Q	SAMD11_uc001abx.1_Missense_Mutation_p.E423Q	NM_152486	NP_689699	Q96NU1	SAM11_HUMAN	sterile alpha motif domain containing 11	560	SAM.					nucleus					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.74e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000472)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		TGGCTGTGGAGAGTACACTCG	0.657		NaN											0	0	0	0.013537	0	11	37									
AGRN	375790	broad.mit.edu	37	1	970701	970701	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:970701G>A	uc001ack.1	+	3	558	c.508G>A	c.(508-510)GAT>AAT	p.D170N		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	170					axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		GACGCCTCCTGATGGTGAGTA	0.597		NaN											0	0	0	0.003954	0	22	113									
CCDC27	148870	broad.mit.edu	37	1	3672032	3672032	+	Missense_Mutation	SNP	G	G	A	rs139820400		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:3672032G>A	uc001akv.2	+	3	535	c.454G>A	c.(454-456)GAG>AAG	p.E152K		NM_152492	NP_689705	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	152										skin(1)	1	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		TTCACCCACTGAGGCCGATTT	0.552		NaN											0	0	0	0.01441	0	121	235									
CHD5	26038	broad.mit.edu	37	1	6181225	6181225	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:6181225G>A	uc001amb.1	-	33	4952	c.4852C>T	c.(4852-4854)CGA>TGA	p.R1618*	CHD5_uc001alz.1_Nonsense_Mutation_p.R475*|CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1618					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CGCTCCTCTCGGGCTCTCTCC	0.647		NaN											0	0	0	0.001984	0	7	16									
ICMT	23463	broad.mit.edu	37	1	6291999	6291999	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:6291999G>A	uc001amk.2	-	4	708	c.635C>T	c.(634-636)TCT>TTT	p.S212F	ICMT_uc001aml.2_Missense_Mutation_p.S116F	NM_012405	NP_036537	O60725	ICMT_HUMAN	isoprenylcysteine carboxyl methyltransferase	212					protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane|membrane fraction	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity				0	Ovarian(185;0.0634)	all_cancers(23;5.85e-39)|all_epithelial(116;2.4e-22)|all_lung(118;2.65e-08)|Lung NSC(185;6.45e-07)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000688)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;5.52e-38)|GBM - Glioblastoma multiforme(13;6.51e-32)|OV - Ovarian serous cystadenocarcinoma(86;3.03e-19)|Colorectal(212;7.08e-08)|COAD - Colon adenocarcinoma(227;8.35e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(365;0.00109)|STAD - Stomach adenocarcinoma(132;0.00313)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		CCCGACGTAAGAAGGATGCCG	0.348		NaN											0	0	0	0.004656	0	22	47									
KIF1B	23095	broad.mit.edu	37	1	10335485	10335485	+	Splice_Site	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:10335485G>C	uc001aqx.3	+	11	1085	c.883_splice	c.e11-1	p.S295_splice	KIF1B_uc001aqv.3_Splice_Site_p.S289_splice|KIF1B_uc001aqw.3_Splice_Site_p.S289_splice|KIF1B_uc001aqy.2_Splice_Site_p.S295_splice|KIF1B_uc001aqz.2_Splice_Site_p.S295_splice|KIF1B_uc001ara.2_Splice_Site_p.S295_splice|KIF1B_uc001arb.2_Splice_Site_p.S295_splice	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b						anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		TCCTTTAATAGAGTAAAAAGA	0.323		NaN											0	0	0	0.008291	0	11	66									
LOC440563	440563	broad.mit.edu	37	1	13183488	13183488	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:13183488G>C	uc010obg.1	-	1	480	c.385C>G	c.(385-387)CGT>GGT	p.R129G		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	129						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						GGAGGTACACGTGCTGGGAAA	0.512		NaN											0	0	0	0.01441	0	58	291									
PADI4	23569	broad.mit.edu	37	1	17681136	17681136	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:17681136G>A	uc001baj.2	+	11	1292	c.1264G>A	c.(1264-1266)GAA>AAA	p.E422K		NM_012387	NP_036519	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	422					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	CAGGGGCAAGGAATACCCGCT	0.572		NaN											0	0	0	0.010504	0	20	18									
PLA2G2E	30814	broad.mit.edu	37	1	20249137	20249137	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:20249137G>C	uc001bct.1	-	2	210	c.152C>G	c.(151-153)TCC>TGC	p.S51C		NM_014589	NP_055404	Q9NZK7	PA2GE_HUMAN	phospholipase A2, group IIE precursor	51					inflammatory response|lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity				0		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|GBM - Glioblastoma multiforme(114;0.000146)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CGGCCAGTGGGAGCCACCGAT	0.612		NaN											0	0	0	0.013537	0	13	80									
HSPG2	3339	broad.mit.edu	37	1	22178416	22178416	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:22178416G>A	uc001bfj.2	-	54	6914	c.6874C>T	c.(6874-6876)CGT>TGT	p.R2292C	HSPG2_uc009vqd.2_Missense_Mutation_p.R2293C	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2292	Ig-like C2-type 8.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CGGGAGCCACGAACCTGGGCA	0.672		NaN											0	0	0	0.001984	0	7	14									
PTAFR	5724	broad.mit.edu	37	1	28477482	28477482	+	Silent	SNP	G	G	T	rs143590918		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:28477482G>T	uc001bpl.2	-	2	178	c.51C>A	c.(49-51)CTC>CTA	p.L17L	PTAFR_uc001bpm.3_Silent_p.L17L|PTAFR_uc009vte.2_Silent_p.L17L	NM_000952	NP_000943	P25105	PTAFR_HUMAN	platelet-activating factor receptor	17	Helical; Name=1; (Potential).				chemotaxis|inflammatory response|interferon-gamma-mediated signaling pathway|phosphatidylinositol-mediated signaling	integral to plasma membrane|nucleus	phospholipid binding|platelet activating factor receptor activity				0		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00715)|all_lung(284;0.00732)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.215)|OV - Ovarian serous cystadenocarcinoma(117;6e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|STAD - Stomach adenocarcinoma(196;0.00678)|READ - Rectum adenocarcinoma(331;0.0649)		CAATCGGGAAGAGAGTGTATC	0.527		NaN											1	0	0.000673444	0.008291	0.0006841	8	49									
DLGAP3	58512	broad.mit.edu	37	1	35331860	35331860	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:35331860G>A	uc001byc.2	-	10	2764	c.2764C>T	c.(2764-2766)CGG>TGG	p.R922W		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	922					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				CCCCGGCCCCGCAGGGGCTTC	0.716		NaN									OREG0013353	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	4	11									
TFAP2E	339488	broad.mit.edu	37	1	36056363	36056363	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:36056363C>A	uc010ohy.1	+	6	1241	c.1033C>A	c.(1033-1035)CTG>ATG	p.L345M	PSMB2_uc001bzd.1_Intron	NM_178548	NP_848643	Q6VUC0	AP2E_HUMAN	transcription factor AP-2 epsilon (activating	345	H-S-H (helix-span-helix), dimerization.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				CAAGAGCATGCTGCTGGCTGC	0.612		NaN											1	0	0.00024832	0.009096	0.000253452	3	18									
MACF1	23499	broad.mit.edu	37	1	39893741	39893741	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:39893741G>A	uc010oiu.1	+	27	12036	c.11905G>A	c.(11905-11907)GAA>AAA	p.E3969K	MACF1_uc010ois.1_Missense_Mutation_p.E3467K|MACF1_uc001cda.1_Missense_Mutation_p.E3354K|MACF1_uc001cdc.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	5534	Spectrin 8.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGTGCTGTCAGAAAAGATAGA	0.498		NaN											0	0	0	0.000602	0	5	66									
HIVEP3	59269	broad.mit.edu	37	1	42049173	42049173	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:42049173C>T	uc001cgz.3	-	4	2509	c.1296G>A	c.(1294-1296)CTG>CTA	p.L432L	HIVEP3_uc001cha.3_Silent_p.L432L|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	432	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				AGGTGGCTGTCAGCATGGCGG	0.617		NaN											0	0	0	0.003163	0	15	33									
MPL	4352	broad.mit.edu	37	1	43805111	43805111	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:43805111G>A	uc001ciw.2	+	4	606	c.561G>A	c.(559-561)CTG>CTA	p.L187L	MPL_uc001civ.2_Silent_p.L187L|MPL_uc009vwr.2_Silent_p.L180L	NM_005373	NP_005364	P40238	TPOR_HUMAN	myeloproliferative leukemia virus oncogene	187	Extracellular (Potential).|Fibronectin type-III 1.				cell proliferation|platelet activation	integral to plasma membrane	cytokine receptor activity			haematopoietic_and_lymphoid_tissue(361)|upper_aerodigestive_tract(1)|pancreas(1)	363	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TCATACAGCTGATTGCCACAG	0.577		NaN	Mis		MPD	MPD	congenital amegakaryocytic thrombocytopenia						0	0	0	0.007835	0	41	75									
IPP	3652	broad.mit.edu	37	1	46182672	46182672	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:46182672C>T	uc001cou.2	-	7	1471	c.1204G>A	c.(1204-1206)GAG>AAG	p.E402K	IPP_uc001cos.3_Missense_Mutation_p.E402K	NM_005897	NP_005888	Q9Y573	IPP_HUMAN	intracisternal A particle-promoted polypeptide	402	Kelch 3.					actin cytoskeleton|cytoplasm	actin binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					TTCCCTATCTCAGCTCCAACC	0.323		NaN											0	0	0	0.010729	0	11	98									
CYP4A11	1579	broad.mit.edu	37	1	47406995	47406995	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:47406995G>A	uc001cqp.3	-	1	162	c.111C>T	c.(109-111)CTC>CTT	p.L37L	CYP4A11_uc001cqq.2_Silent_p.L37L|CYP4A11_uc010omm.1_RNA	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	37					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	TGTGCAGGTAGAGCTGAACTG	0.602		NaN											0	0	0	0.001984	0	7	130									
FOXD2	2306	broad.mit.edu	37	1	47904552	47904552	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:47904552G>A	uc001crm.2	+	1	2864	c.745G>A	c.(745-747)GCG>ACG	p.A249T		NM_004474	NP_004465	O60548	FOXD2_HUMAN	forkhead box D2	249	Ala-rich.|Pro-rich.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0				READ - Rectum adenocarcinoma(2;0.0908)		cggggccgcggcggcgggggA	0.617		NaN											0	0	0	0.008291	0	11	5									
LRP8	7804	broad.mit.edu	37	1	53755276	53755276	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:53755276C>T	uc001cvi.1	-	3	472	c.330G>A	c.(328-330)GAG>GAA	p.E110E	LRP8_uc001cvh.1_Translation_Start_Site|LRP8_uc001cvk.1_Silent_p.E110E|LRP8_uc001cvj.1_Silent_p.E110E|LRP8_uc001cvl.1_Silent_p.E110E	NM_004631	NP_004622	Q14114	LRP8_HUMAN	low density lipoprotein receptor-related protein	110	LDL-receptor class A 2.|Extracellular (Potential).				cytokine-mediated signaling pathway|endocytosis|lipid metabolic process|platelet activation|proteolysis	caveola	calcium ion binding|very-low-density lipoprotein particle receptor activity				0						CATCAGGACACTCCTCCTCGC	0.592		NaN											0	0	0	0.000602	0	5	14									
CDCP2	200008	broad.mit.edu	37	1	54606823	54606823	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:54606823G>C	uc001cwv.1	-	3	1559	c.711C>G	c.(709-711)TTC>TTG	p.F237L		NM_201546	NP_963840	Q5VXM1	CDCP2_HUMAN	CUB domain containing protein 2 precursor	237	CUB 2.					extracellular region				ovary(1)	1						AGTCGGACTTGAAGACCACCT	0.547		NaN											0	0	0	0.004482	0	8	48									
DAB1	1600	broad.mit.edu	37	1	57489208	57489208	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:57489208G>A	uc001cys.1	-	13	1565	c.891C>T	c.(889-891)CCC>CCT	p.P297P	DAB1_uc001cyt.1_Silent_p.P295P|DAB1_uc001cyq.1_Silent_p.P295P|DAB1_uc001cyr.1_Silent_p.P211P|DAB1_uc009vzw.1_Silent_p.P279P|DAB1_uc009vzx.1_Silent_p.P297P	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	330					cell differentiation|nervous system development					skin(2)|ovary(1)	3						GCTTACCTGAGGGTACAGCAG	0.493		NaN											0	0	0	0.001984	0	7	11									
C1orf87	127795	broad.mit.edu	37	1	60505607	60505607	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:60505607C>A	uc001czs.1	-	5	821	c.729G>T	c.(727-729)AAG>AAT	p.K243N		NM_152377	NP_689590	Q8N0U7	CA087_HUMAN	hypothetical protein LOC127795	243							calcium ion binding			ovary(1)|breast(1)	2						GAGAACCCCTCTTAGAAAATC	0.408		NaN											1	0	4.35082e-09	0.010504	4.58658e-09	21	122									
INADL	10207	broad.mit.edu	37	1	62237176	62237176	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:62237176C>T	uc001dab.2	+	6	712	c.598C>T	c.(598-600)CAG>TAG	p.Q200*	INADL_uc009waf.1_Nonsense_Mutation_p.Q200*|INADL_uc001daa.2_Nonsense_Mutation_p.Q200*|INADL_uc001dad.3_5'UTR	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	200	PDZ 1.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						CATTTCCCATCAGCAAGCAAT	0.373		NaN											0	0	0	0.000602	0	5	59									
INSL5	10022	broad.mit.edu	37	1	67266883	67266883	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:67266883G>C	uc001dcw.2	-	1	57	c.22C>G	c.(22-24)CTG>GTG	p.L8V		NM_005478	NP_005469	Q9Y5Q6	INSL5_HUMAN	insulin-like 5 precursor	8						extracellular region	hormone activity				0						AATAAAAACAGAGTGAAAATG	0.418		NaN											0	0	0	0.009096	0	4	32									
C1orf173	127254	broad.mit.edu	37	1	75097549	75097549	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:75097549G>C	uc001dgg.2	-	7	886	c.667C>G	c.(667-669)CAA>GAA	p.Q223E	C1orf173_uc001dgi.3_Missense_Mutation_p.Q17E	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	223										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TTTGGAAGTTGATATGAATTC	0.403		NaN											0	0	0	0.005524	0	37	48									
EPHX4	253152	broad.mit.edu	37	1	92528691	92528691	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:92528691G>A	uc001don.2	+	7	1041	c.937G>A	c.(937-939)GAG>AAG	p.E313K		NM_173567	NP_775838	Q8IUS5	EPHX4_HUMAN	abhydrolase domain containing 7	313						integral to membrane	hydrolase activity			central_nervous_system(1)	1						CATGGAGGTTGAGATGGCTGA	0.418		NaN											0	0	0	0.01441	0	52	81									
RPAP2	79871	broad.mit.edu	37	1	92799022	92799022	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:92799022G>C	uc001dot.2	+	9	1639	c.1530G>C	c.(1528-1530)TTG>TTC	p.L510F	RPAP2_uc009wdh.2_RNA	NM_024813	NP_079089	Q8IXW5	RPAP2_HUMAN	RNA polymerase II associated protein 2	510						integral to membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)	1		all_lung(203;0.0565)|Lung NSC(277;0.152)|Glioma(108;0.222)		all cancers(265;0.00647)|GBM - Glioblastoma multiforme(16;0.0234)|Epithelial(280;0.115)		TTGAAAAGTTGAGTAAAGTGT	0.333		NaN											0	0	0	0.001984	0	5	70									
EVI5	7813	broad.mit.edu	37	1	93170221	93170221	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:93170221G>A	uc001dox.2	-	3	372	c.362C>T	c.(361-363)TCA>TTA	p.S121L	EVI5_uc010otf.1_Missense_Mutation_p.S121L	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5	121	Interaction with alpha-tubulin, gamma- tubulin, BIRC5 and FBXO5.|Ser-rich.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		AGAGGCTGATGAACTCGACAC	0.363		NaN											0	0	0	0.006214	0	9	127									
SNX7	51375	broad.mit.edu	37	1	99161250	99161250	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:99161250G>C	uc010ouc.1	+	5	868	c.816G>C	c.(814-816)CAG>CAC	p.Q272H	SNX7_uc001dsa.2_Missense_Mutation_p.Q208H|SNX7_uc010oud.1_Missense_Mutation_p.Q217H	NM_015976	NP_057060	Q9UNH6	SNX7_HUMAN	sorting nexin 7 isoform a	208					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		all_epithelial(167;7.64e-07)|all_lung(203;0.0006)|Lung NSC(277;0.00137)		Epithelial(280;0.0521)|all cancers(265;0.0687)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.207)|Colorectal(170;0.234)		AAATATCTCAGAGAATTTATA	0.313		NaN											0	0	0	0.001168	0	6	93									
S1PR1	1901	broad.mit.edu	37	1	101704981	101704981	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:101704981G>A	uc001dud.2	+	2	955	c.441G>A	c.(439-441)CTG>CTA	p.L147L	S1PR1_uc009weg.2_Silent_p.L147L	NM_001400	NP_001391	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	147	Cytoplasmic (By similarity).				cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)	3						TCACAATGCTGAAAATGAAAC	0.557		NaN									OREG0013620	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	47	52									
STXBP3	6814	broad.mit.edu	37	1	109339276	109339276	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:109339276G>A	uc001dvy.2	+	15	1359	c.1284G>A	c.(1282-1284)CAG>CAA	p.Q428Q	STXBP3_uc001dvz.2_RNA	NM_007269	NP_009200	O00186	STXB3_HUMAN	syntaxin binding protein 3	428					negative regulation of calcium ion-dependent exocytosis|neutrophil degranulation|platelet aggregation|protein transport|vesicle docking involved in exocytosis	cytosol|nucleus|platelet alpha granule|specific granule|tertiary granule	syntaxin-2 binding			ovary(3)|central_nervous_system(1)	4		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0386)|Lung(183;0.104)|COAD - Colon adenocarcinoma(174;0.137)|Epithelial(280;0.231)		GGTTGATCCAGAATGTAAAGA	0.353		NaN											0	0	0	0.001984	0	6	62									
AKNAD1	254268	broad.mit.edu	37	1	109359687	109359687	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:109359687C>T	uc001dwa.2	-	15	2631	c.2362G>A	c.(2362-2364)GAA>AAA	p.E788K	AKNAD1_uc001dwb.2_RNA	NM_152763	NP_689976	Q5T1N1	AKND1_HUMAN	hypothetical protein LOC254268	788										ovary(3)	3						TTTATTTCTTCAGTGCTATCA	0.443		NaN											0	0	0	0.007291	0	30	56									
GSTM3	2947	broad.mit.edu	37	1	110280351	110280351	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:110280351A>T	uc001dyo.2	-	7	705	c.395T>A	c.(394-396)TTG>TAG	p.L132*	GSTM3_uc001dyp.2_Nonsense_Mutation_p.L129*|GSTM3_uc010ovv.1_Nonsense_Mutation_p.L132*	NM_000849	NP_000840	P21266	GSTM3_HUMAN	glutathione S-transferase mu 3	132	GST C-terminal.				establishment of blood-nerve barrier|glutathione metabolic process|response to estrogen stimulus	cytoplasm	glutathione transferase activity|identical protein binding				0		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Colorectal(144;0.0339)|Lung(183;0.0426)|all cancers(265;0.113)|Epithelial(280;0.125)|COAD - Colon adenocarcinoma(174;0.134)|LUSC - Lung squamous cell carcinoma(189;0.228)	Glutathione(DB00143)	TAGCTCTTCCAAGTACTGAGG	0.433		NaN											0	0	0	0.01441	0	45	93									
CHIA	27159	broad.mit.edu	37	1	111862083	111862083	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:111862083G>A	uc001eas.2	+	11	1273	c.1170G>A	c.(1168-1170)CAG>CAA	p.Q390Q	CHIA_uc001ear.2_Silent_p.Q282Q|CHIA_uc001eaq.2_Silent_p.Q282Q|CHIA_uc009wgc.2_Silent_p.Q282Q|CHIA_uc001eat.2_Silent_p.Q229Q|CHIA_uc001eav.2_Silent_p.Q229Q|CHIA_uc001eau.2_Silent_p.Q229Q|CHIA_uc009wgd.2_Silent_p.Q229Q	NM_201653	NP_970615	Q9BZP6	CHIA_HUMAN	acidic chitinase isoform c	390					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			ovary(1)	1		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		TCGGCCTGCAGAGTGCAAGTA	0.542		NaN											0	0	0	0.003954	0	24	29									
PDE4DIP	9659	broad.mit.edu	37	1	144879302	144879302	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:144879302G>A	uc001elw.3	-	27	4439	c.4148C>T	c.(4147-4149)TCA>TTA	p.S1383L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.S1339L|PDE4DIP_uc001elv.3_Missense_Mutation_p.S390L	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1383	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		ACTTGTAACTGAGAGGGACCG	0.502		NaN	T	PDGFRB	MPD								0	0	0	0.01441	0	58	220									
NBPF10	100132406	broad.mit.edu	37	1	145296564	145296564	+	Silent	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:145296564C>G	uc001end.3	+	3	521	c.486C>G	c.(484-486)CTC>CTG	p.L162L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Silent_p.L162L|NBPF10_uc001emq.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	162											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TCCAAAAGCTCAGCCCAGGTA	0.572		NaN											0	0	0	0.006122	0	13	228									
HIST2H2AB	317772	broad.mit.edu	37	1	149859417	149859417	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:149859417G>C	uc001ete.2	-	1	50	c.50C>G	c.(49-51)TCG>TGG	p.S17W	HIST2H2BE_uc001etc.2_5'Flank	NM_175065	NP_778235	Q8IUE6	H2A2B_HUMAN	histone cluster 2, H2ab	17					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|breast(1)	2	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			GGACGAGCGCGACTTGGCCTT	0.622		NaN											0	0	0	0.014323	0	20	102									
ZNF687	57592	broad.mit.edu	37	1	151262298	151262298	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:151262298G>A	uc001exq.2	+	6	2877	c.2779G>A	c.(2779-2781)GAA>AAA	p.E927K	ZNF687_uc009wmo.2_Missense_Mutation_p.E927K|ZNF687_uc009wmp.2_Missense_Mutation_p.E927K	NM_020832	NP_065883	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	927	Poly-Glu.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			central_nervous_system(3)|ovary(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TTCATCTTCAGAAGAGGAGGA	0.667		NaN											0	0	0	0.004672	0	3	5									
SLC27A3	11000	broad.mit.edu	37	1	153748380	153748380	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:153748380G>A	uc001fcz.2	+	1	613	c.548G>A	c.(547-549)GGA>GAA	p.G183E	SLC27A3_uc009won.2_RNA	NM_024330	NP_077306	Q5K4L6	S27A3_HUMAN	solute carrier family 27 member 3	183					fatty acid metabolic process	integral to membrane|mitochondrial membrane	ligase activity|nucleotide binding			ovary(1)	1	all_lung(78;6.47e-32)|Lung NSC(65;2.52e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GCAGCGCCGGGAGCCGGAGAT	0.741		NaN											0	0	0	0.001168	0	5	15									
CRTC2	200186	broad.mit.edu	37	1	153923847	153923847	+	Silent	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:153923847G>T	uc010ped.1	-	11	1363	c.1293C>A	c.(1291-1293)CCC>CCA	p.P431P	CRTC2_uc001fde.3_RNA|CRTC2_uc001fdf.3_Intron	NM_181715	NP_859066	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	431					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)	2	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GGGGGCTGAGGGGCACACGGC	0.557		NaN											1	0	2.7689e-08	0.001984	2.90938e-08	7	24									
PMVK	10654	broad.mit.edu	37	1	154898934	154898934	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:154898934G>A	uc001ffq.2	-	4	661	c.338C>T	c.(337-339)TCT>TTT	p.S113F		NM_006556	NP_006547	Q15126	PMVK_HUMAN	phosphomevalonate kinase	113					cholesterol biosynthetic process|protein phosphorylation	cytosol|peroxisome	ATP binding|phosphomevalonate kinase activity|protein binding				0	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.142)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CTGGATGTCAGACACTCTCCG	0.607		NaN											0	0	0	0.006122	0	18	20									
OR10R2	343406	broad.mit.edu	37	1	158450384	158450384	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:158450384C>T	uc010pik.1	+	1	717	c.717C>T	c.(715-717)CTC>CTT	p.L239L	uc001fso.1_RNA	NM_001004472	NP_001004472	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R,	239	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)					TTTCTTATCTCTGCATTCTGA	0.428		NaN											0	0	0	0.001855	0	14	118									
AIM2	9447	broad.mit.edu	37	1	159035839	159035839	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:159035839C>T	uc001ftj.1	-	4	922	c.677G>A	c.(676-678)CGT>CAT	p.R226H		NM_004833	NP_004824	O14862	AIM2_HUMAN	absent in melanoma 2	226	HIN-200.				cellular response to drug|immune response|interleukin-1 beta secretion	mitochondrion|nucleus				ovary(2)|pancreas(1)	3	all_hematologic(112;0.0429)					ATCTAACACACGTGAGGCGCT	0.393		NaN											0	0	0	0.01441	0	59	108									
NCSTN	23385	broad.mit.edu	37	1	160318836	160318836	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:160318836G>A	uc001fvx.2	+	3	362	c.238G>A	c.(238-240)GAG>AAG	p.E80K	NCSTN_uc009wtk.1_RNA|NCSTN_uc001fvy.2_Missense_Mutation_p.E60K|NCSTN_uc010pjf.1_Missense_Mutation_p.E80K|NCSTN_uc001fvz.2_5'Flank|NCSTN_uc010pjg.1_5'Flank	NM_015331	NP_056146	Q92542	NICA_HUMAN	nicastrin precursor	80	Extracellular (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			ovary(1)|lung(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AGAGAAAGAGGAGGACCTACA	0.463		NaN											0	0	0	0.012319	0	22	68									
NCSTN	23385	broad.mit.edu	37	1	160319451	160319451	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:160319451G>A	uc001fvx.2	+	4	551	c.427G>A	c.(427-429)GAT>AAT	p.D143N	NCSTN_uc009wtk.1_RNA|NCSTN_uc001fvy.2_Missense_Mutation_p.D123N|NCSTN_uc010pjf.1_Missense_Mutation_p.D143N|NCSTN_uc001fvz.2_5'Flank|NCSTN_uc010pjg.1_5'Flank	NM_015331	NP_056146	Q92542	NICA_HUMAN	nicastrin precursor	143	Extracellular (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			ovary(1)|lung(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GTGCCCAAATGATGGGTTTGG	0.507		NaN											0	0	0	0.006122	0	18	25									
DUSP12	11266	broad.mit.edu	37	1	161726695	161726695	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:161726695G>T	uc001gbo.2	+	6	992	c.981G>T	c.(979-981)ATG>ATT	p.M327I	DUSP12_uc001gbp.2_Missense_Mutation_p.M197I	NM_007240	NP_009171	Q9UNI6	DUS12_HUMAN	dual specificity phosphatase 12	327					positive regulation of glucokinase activity	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|zinc ion binding			breast(1)	1	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			TGGATGAAATGAAAATATTGC	0.388		NaN											1	0	4.14922e-12	0.004007	4.46197e-12	16	81									
ALDH9A1	223	broad.mit.edu	37	1	165648806	165648806	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:165648806G>T	uc001gdh.1	-	6	908	c.803C>A	c.(802-804)TCA>TAA	p.S268*	ALDH9A1_uc010pky.1_Nonsense_Mutation_p.S174*|ALDH9A1_uc010pkz.1_Nonsense_Mutation_p.S258*|ALDH9A1_uc010pla.1_Nonsense_Mutation_p.S174*	NM_000696	NP_000687	P49189	AL9A1_HUMAN	aldehyde dehydrogenase 9A1	244					carnitine biosynthetic process|cellular aldehyde metabolic process|hormone metabolic process|neurotransmitter biosynthetic process	cytosol|plasma membrane	3-chloroallyl aldehyde dehydrogenase activity|4-trimethylammoniobutyraldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|aminobutyraldehyde dehydrogenase activity				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				NADH(DB00157)	TCCTTTAGCTGACATCTCCAT	0.413		NaN											1	0	3.65163e-15	0.00632	3.96004e-15	25	154									
POGK	57645	broad.mit.edu	37	1	166810266	166810266	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:166810266G>A	uc001gdt.1	+	2	193	c.73G>A	c.(73-75)GAA>AAA	p.E25K	POGK_uc010ple.1_5'UTR|POGK_uc010plf.1_5'UTR	NM_017542	NP_060012	Q9P215	POGK_HUMAN	pogo transposable element with KRAB domain	25	Potential.				multicellular organismal development|regulation of transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						TCAGAGCCGGGAACTAGAGGA	0.517		NaN											0	0	0	0.009718	0	45	88									
C1orf129	80133	broad.mit.edu	37	1	170959046	170959046	+	Silent	SNP	T	T	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:170959046T>C	uc001ghg.2	+	11	1060	c.930T>C	c.(928-930)TGT>TGC	p.C310C	C1orf129_uc009wvy.2_Silent_p.C117C|C1orf129_uc010plz.1_Silent_p.C310C	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	310							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ATAACAATTGTATGAAGGATG	0.423		NaN											0	0	0	0.01441	0	65	108									
C1orf129	80133	broad.mit.edu	37	1	170965666	170965666	+	Silent	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:170965666G>C	uc001ghg.2	+	14	1486	c.1356G>C	c.(1354-1356)CTG>CTC	p.L452L	C1orf129_uc009wvy.2_Silent_p.L259L|C1orf129_uc010plz.1_Silent_p.L452L	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	452							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AGGATGCCCTGAGAGTTCTGC	0.418		NaN											0	0	0	0.010504	0	20	109									
KLHL20	27252	broad.mit.edu	37	1	173703360	173703360	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:173703360G>A	uc001gjc.2	+	3	711	c.532G>A	c.(532-534)GAC>AAC	p.D178N	KLHL20_uc010pmr.1_Intron|KLHL20_uc009wwf.2_Missense_Mutation_p.D160N|KLHL20_uc001gjd.2_Missense_Mutation_p.D178N	NM_014458	NP_055273	Q9Y2M5	KLH20_HUMAN	kelch-like 20	178	BACK.				cytoskeleton organization|negative regulation of apoptosis|proteasomal ubiquitin-dependent protein catabolic process|response to interferon-alpha	actin cytoskeleton|cell surface|Cul3-RING ubiquitin ligase complex|Golgi apparatus|perinuclear region of cytoplasm|PML body	actin binding|interferon-gamma binding|ubiquitin-protein ligase activity			ovary(1)	1						GGCTTTTGCTGACACACATTC	0.463		NaN											0	0	0	0.001984	0	6	80									
PAPPA2	60676	broad.mit.edu	37	1	176681100	176681100	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:176681100G>A	uc001gkz.2	+	12	4945	c.3781G>A	c.(3781-3783)GAT>AAT	p.D1261N	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1261					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GAAGAAAGAGGATGAGGTTTG	0.398		NaN											0	0	0	0.001984	0	6	78									
TOR1AIP1	26092	broad.mit.edu	37	1	179887135	179887135	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:179887135G>C	uc001gnq.2	+	10	1731	c.1513G>C	c.(1513-1515)GAT>CAT	p.D505H		NM_015602	NP_056417	Q5JTV8	TOIP1_HUMAN	lamina-associated polypeptide 1B	505	Lumenal (Potential).					integral to membrane|nuclear inner membrane				breast(1)|central_nervous_system(1)	2						GGCCTTCAAAGATGTAGCCTT	0.428		NaN											0	0	0	0.00308	0	8	140									
APOBEC4	403314	broad.mit.edu	37	1	183616842	183616842	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:183616842C>T	uc001gqn.2	-	2	1347	c.1075G>A	c.(1075-1077)GAA>AAA	p.E359K	RGL1_uc010pof.1_Intron|RGL1_uc001gqm.2_Intron|RGL1_uc010pog.1_Intron|RGL1_uc010poh.1_Intron	NM_203454	NP_982279	Q8WW27	ABEC4_HUMAN	apolipoprotein B	359					mRNA processing		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding				0						TTCTTCTTTTCATCTGCCTCC	0.408		NaN											0	0	0	0.00278	0	21	162									
HMCN1	83872	broad.mit.edu	37	1	186082010	186082010	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:186082010G>A	uc001grq.1	+	72	11285	c.11056G>A	c.(11056-11058)GAT>AAT	p.D3686N		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3686	Ig-like C2-type 35.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TGACCTAGGTGATACAGCCAA	0.403		NaN											0	0	0	0.008871	0	21	74									
GPR37L1	9283	broad.mit.edu	37	1	202097339	202097339	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:202097339C>T	uc001gxj.2	+	2	1164	c.1101C>T	c.(1099-1101)GTC>GTT	p.V367V		NM_004767	NP_004758	O60883	ETBR2_HUMAN	G-protein coupled receptor 37 like 1 precursor	367	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|central_nervous_system(1)	2						TGACCGTGGTCTACGCCTTCT	0.647		NaN											0	0	0	0.006214	0	9	113									
KDM5B	10765	broad.mit.edu	37	1	202700976	202700976	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:202700976C>T	uc001gyf.2	-	24	4117	c.4001G>A	c.(4000-4002)CGA>CAA	p.R1334Q	KDM5B_uc009xag.2_Missense_Mutation_p.R1370Q|KDM5B_uc001gyg.1_Missense_Mutation_p.R1176Q	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	1334					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						GATACAACTTCGTCCAGTTGA	0.408		NaN											0	0	0	0.001984	0	7	75									
KDM5B	10765	broad.mit.edu	37	1	202703015	202703015	+	Splice_Site	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:202703015C>G	uc001gyf.2	-	23	3540	c.3424_splice	c.e23-1	p.M1142_splice	KDM5B_uc009xag.2_Splice_Site_p.M1178_splice|KDM5B_uc001gyg.1_Splice_Site_p.M984_splice	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B						negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						GAGTTGCCATCTGAAAAAGAG	0.418		NaN											0	0	0	0.012319	0	20	143									
RBBP5	5929	broad.mit.edu	37	1	205070807	205070807	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:205070807G>C	uc001hbu.1	-	6	683	c.553C>G	c.(553-555)CTT>GTT	p.L185V	RBBP5_uc010prd.1_Missense_Mutation_p.L220V|RBBP5_uc001hbv.1_Missense_Mutation_p.L185V|RBBP5_uc010pre.1_Missense_Mutation_p.L52V	NM_005057	NP_005048	Q15291	RBBP5_HUMAN	retinoblastoma binding protein 5	185	WD 3.				histone H3-K4 methylation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription, DNA-dependent	MLL1 complex|Set1C/COMPASS complex	methylated histone residue binding|transcription regulatory region DNA binding			lung(1)	1	Breast(84;0.0505)		BRCA - Breast invasive adenocarcinoma(75;0.0923)			GAAGCAACAAGATCCTGAGAA	0.393		NaN											0	0	0	0.01441	0	59	122									
C4BPA	722	broad.mit.edu	37	1	207314612	207314612	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:207314612C>T	uc001hfo.2	+	10	1629	c.1435C>T	c.(1435-1437)CAA>TAA	p.Q479*		NM_000715	NP_000706	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	479	Sushi 7.				complement activation, classical pathway|innate immune response	extracellular region	protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						TCCAGCCCCTCAATGTAAAGG	0.463		NaN											0	0	0	0.008871	0	19	86									
EPRS	2058	broad.mit.edu	37	1	220208271	220208271	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:220208271C>T	uc001hly.1	-	3	486	c.216G>A	c.(214-216)CTG>CTA	p.L72L	EPRS_uc010puf.1_5'UTR|EPRS_uc001hlz.1_Silent_p.L72L|EPRS_uc009xdt.1_5'UTR	NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	72					glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	TATGTTCCATCAGATTAGAGC	0.363		NaN											0	0	0	0.01441	0	45	71									
C1orf198	84886	broad.mit.edu	37	1	231004195	231004195	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:231004195G>C	uc001hub.2	-	1	108	c.64C>G	c.(64-66)CTG>GTG	p.L22V	C1orf198_uc001huc.1_Intron|C1orf198_uc001hud.1_Intron	NM_032800	NP_116189	Q9H425	CA198_HUMAN	hypothetical protein LOC84886 isoform 1	22											0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				CGGTCGTCCAGAGGCCGGTTC	0.567		NaN											0	0	0	0.001168	0	5	10									
WDR64	128025	broad.mit.edu	37	1	241951319	241951319	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:241951319G>A	uc001hzf.1	+	13	1656	c.1503G>A	c.(1501-1503)CTG>CTA	p.L501L	WDR64_uc001hzg.1_Silent_p.L414L	NM_144625	NP_653226	B1ANS9	WDR64_HUMAN	WD repeat domain 64	948										skin(1)	1	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			AATATCCTCTGATATTTGACC	0.358		NaN											0	0	0	0.005443	0	27	58									
HNRNPU	3192	broad.mit.edu	37	1	245019785	245019785	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:245019785G>C	uc001iaz.1	-	10	2104	c.1886C>G	c.(1885-1887)CCA>CGA	p.P629R	HNRNPU_uc001iaw.1_RNA|HNRNPU_uc001iax.1_RNA|HNRNPU_uc001iay.1_Missense_Mutation_p.P353R|HNRNPU_uc001iba.1_Missense_Mutation_p.P610R|HNRNPU_uc001ibb.1_Missense_Mutation_p.P317R	NM_031844	NP_114032	Q00839	HNRPU_HUMAN	heterogeneous nuclear ribonucleoprotein U	629					CRD-mediated mRNA stabilization	catalytic step 2 spliceosome|cell surface|CRD-mediated mRNA stability complex|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	ATP binding|DNA binding|protein binding|RNA binding				0	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			CGCATGTTCTGGTAGGTCTTT	0.378		NaN											0	0	0	0.00278	0	20	137									
CNST	163882	broad.mit.edu	37	1	246810440	246810440	+	Splice_Site	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:246810440G>A	uc001ibp.2	+	9	1316	c.938_splice	c.e9-1	p.E313_splice	CNST_uc001ibo.3_Splice_Site_p.E313_splice	NM_152609	NP_689822	Q6PJW8	CNST_HUMAN	hypothetical protein LOC163882 isoform 1						positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding				0						TTCATCTTTAGAGAGTAAAAC	0.383		NaN									OREG0014367	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003163	0	16	75									
C10orf18	54906	broad.mit.edu	37	10	5789126	5789126	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:5789126G>A	uc001iij.2	+	15	4367	c.3742G>A	c.(3742-3744)GAA>AAA	p.E1248K	C10orf18_uc001iik.2_Missense_Mutation_p.E92K	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	1248										ovary(1)|central_nervous_system(1)	2						TCCAAACACTGAAAATATGAA	0.408		NaN											0	0	0	0.01441	0	48	83									
IL2RA	3559	broad.mit.edu	37	10	6104059	6104059	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:6104059C>T	uc001iiz.1	-	1	215	c.56G>A	c.(55-57)TGC>TAC	p.C19Y	IL2RA_uc009xih.1_Missense_Mutation_p.C19Y	NM_000417	NP_000408	P01589	IL2RA_HUMAN	interleukin 2 receptor, alpha chain precursor	19					cell proliferation	integral to membrane	interleukin-2 receptor activity			ovary(1)|skin(1)	2					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	ACCTGCCTGGCAGCCAGGCAC	0.612		NaN											0	0	0	0.008291	0	9	87									
NSUN6	221078	broad.mit.edu	37	10	18940106	18940106	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:18940106C>G	uc010qcp.1	-	1	445	c.27G>C	c.(25-27)TTG>TTC	p.L9F		NM_182543	NP_872349	Q8TEA1	NSUN6_HUMAN	NOL1/NOP2/Sun domain family, member 6	9							methyltransferase activity|RNA binding			ovary(2)	2						CCTCAGGTCTCAAAGATATCT	0.333		NaN											0	0	0	0.011902	0	41	81									
SVIL	6840	broad.mit.edu	37	10	29747377	29747377	+	Missense_Mutation	SNP	C	C	T	rs147020336		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:29747377C>T	uc001iut.1	-	37	7297	c.6544G>A	c.(6544-6546)GAC>AAC	p.D2182N	LOC387647_uc001iuo.1_Intron|LOC387647_uc001iup.2_Intron|LOC387647_uc001iuq.1_Intron|SVIL_uc010qdw.1_Missense_Mutation_p.D1096N|SVIL_uc001iuu.1_Missense_Mutation_p.D1756N	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	2182	HP.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				AAGTCTTCGTCGGTGAGATAG	0.597		NaN											0	0	0	0.000602	0	5	44									
ITGB1	3688	broad.mit.edu	37	10	33201009	33201009	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:33201009C>G	uc001iws.3	-	12	1649	c.1513G>C	c.(1513-1515)GAT>CAT	p.D505H	ITGB1_uc001iwp.3_Missense_Mutation_p.D505H|ITGB1_uc001iwq.3_Missense_Mutation_p.D505H|ITGB1_uc001iwr.3_Missense_Mutation_p.D505H|ITGB1_uc001iwt.3_Missense_Mutation_p.D505H|ITGB1_uc001iwu.1_Missense_Mutation_p.D505H	NM_133376	NP_596867	P05556	ITB1_HUMAN	integrin beta 1 isoform 1A precursor	505	Extracellular (Potential).|I.|Cysteine-rich tandem repeats.				axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(717;1.34e-05)|Breast(68;0.0634)				TTAACTTCATCTGTGCTGCAT	0.398		NaN											0	0	0	0.013537	0	13	46									
GDF2	2658	broad.mit.edu	37	10	48413872	48413872	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:48413872C>T	uc001jfa.1	-	2	1159	c.996G>A	c.(994-996)CTG>CTA	p.L332L		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	332					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3						AGTTTACCCGCAGGGAGGTCT	0.612		NaN											0	0	0	0.00499	0	16	81									
FRMPD2	143162	broad.mit.edu	37	10	49440294	49440294	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:49440294G>A	uc001jgi.2	-	10	1139	c.1032C>T	c.(1030-1032)CTC>CTT	p.L344L	FRMPD2_uc001jgh.2_Silent_p.L313L|FRMPD2_uc001jgj.2_Silent_p.L322L	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	344	FERM.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		GGACCACACAGAGGTCCCTGA	0.383		NaN											0	0	0	0.008871	0	20	46									
OGDHL	55753	broad.mit.edu	37	10	50944540	50944540	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:50944540C>G	uc001jie.2	-	21	2759	c.2617G>C	c.(2617-2619)GAA>CAA	p.E873Q	OGDHL_uc009xog.2_Missense_Mutation_p.E900Q|OGDHL_uc010qgt.1_Missense_Mutation_p.E816Q|OGDHL_uc010qgu.1_Missense_Mutation_p.E664Q	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	873					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						GCCCCATCTTCAGGAATCACC	0.637		NaN											0	0	0	0.007413	0	19	71									
NCOA4	8031	broad.mit.edu	37	10	51584673	51584673	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:51584673G>C	uc001jis.3	+	8	975	c.772G>C	c.(772-774)GAA>CAA	p.E258Q	PARG_uc001jih.2_Intron|uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron|NCOA4_uc009xon.2_Missense_Mutation_p.E274Q|NCOA4_uc010qhd.1_Missense_Mutation_p.E274Q|NCOA4_uc010qhe.1_Missense_Mutation_p.E158Q|NCOA4_uc010qhf.1_Missense_Mutation_p.E92Q|NCOA4_uc001jit.2_Missense_Mutation_p.E258Q|NCOA4_uc009xoo.2_Missense_Mutation_p.E258Q	NM_001145263	NP_001138735	Q13772	NCOA4_HUMAN	nuclear receptor coactivator 4 isoform 3	258					androgen receptor signaling pathway|male gonad development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	androgen receptor binding|transcription coactivator activity			central_nervous_system(1)|kidney(1)	2						AAAGGGCTTAGAAAACTGGCT	0.383		NaN	T	RET	papillary thyroid 								0	0	0	0.010504	0	21	107									
ANK3	288	broad.mit.edu	37	10	61926588	61926588	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:61926588C>T	uc001jky.2	-	22	2737	c.2545G>A	c.(2545-2547)GAT>AAT	p.D849N	ANK3_uc001jkx.2_Missense_Mutation_p.D27N|ANK3_uc010qih.1_Missense_Mutation_p.D832N|ANK3_uc001jkz.3_Missense_Mutation_p.D843N|ANK3_uc001jlb.1_Missense_Mutation_p.D378N|ANK3_uc001jlc.1_Missense_Mutation_p.D510N	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	849					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						ATACCTTCATCATCAGACATA	0.333		NaN											0	0	0	0.004656	0	24	60									
SLC25A16	8034	broad.mit.edu	37	10	70276532	70276532	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:70276532G>A	uc001joi.2	-	2	651	c.199C>T	c.(199-201)CAC>TAC	p.H67Y	SLC25A16_uc010qix.1_5'UTR|SLC25A16_uc010qiy.1_5'UTR|SLC25A16_uc001joj.2_5'UTR	NM_152707	NP_689920	P16260	GDC_HUMAN	solute carrier family 25, member 16	67	Solcar 1.				coenzyme biosynthetic process|pantothenate metabolic process	integral to membrane|mitochondrial inner membrane	binding|solute:solute antiporter activity				0						TGGTGATTGTGAGCTTGTAAT	0.333		NaN											0	0	0	0.00245	0	15	33									
ANXA11	311	broad.mit.edu	37	10	81932588	81932588	+	Silent	SNP	T	T	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:81932588T>C	uc001kbq.1	-	4	855	c.30A>G	c.(28-30)CCA>CCG	p.P10P	ANXA11_uc010qlx.1_5'Flank|ANXA11_uc001kbr.1_Silent_p.P10P|ANXA11_uc001kbs.1_Silent_p.P10P|ANXA11_uc001kbt.1_Silent_p.P10P|ANXA11_uc010qly.1_5'UTR|ANXA11_uc009xsq.1_Silent_p.P10P|ANXA11_uc001kbu.1_Silent_p.P10P	NM_145869	NP_665876	P50995	ANX11_HUMAN	annexin A11	10					cell cycle|cytokinesis, completion of separation|phagocytosis|response to calcium ion	azurophil granule|melanosome|midbody|nuclear envelope|nucleoplasm|phagocytic vesicle|specific granule|spindle	calcium-dependent phospholipid binding|calcium-dependent protein binding|S100 alpha binding			ovary(1)	1	Prostate(51;0.00985)|all_epithelial(25;0.0951)		Colorectal(32;0.109)			GGTAGCCACCTGGGGGCGGGG	0.617		NaN											0	0	0	0.009535	0	27	61									
BMPR1A	657	broad.mit.edu	37	10	88651946	88651946	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:88651946C>T	uc001kdy.2	+	5	841	c.293C>T	c.(292-294)TCA>TTA	p.S98L		NM_004329	NP_004320	P36894	BMR1A_HUMAN	bone morphogenetic protein receptor, type IA	98	Extracellular (Potential).				BMP signaling pathway|immune response|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	integral to membrane|plasma membrane	ATP binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta receptor activity			lung(3)|large_intestine(1)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	8						ACATTAGCTTCAGGGTGTATG	0.333		NaN	Mis|N|F			gastrointestinal polyps			Hereditary_Mixed_Polyposis_syndrome_type_2|Juvenile_Polyposis				0	0	0	0.004482	0	9	28									
IFIT2	3433	broad.mit.edu	37	10	91066692	91066692	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:91066692G>A	uc009xts.2	+	2	1154	c.979G>A	c.(979-981)GAT>AAT	p.D327N	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|uc001kgd.2_Intron	NM_001547	NP_001538	P09913	IFIT2_HUMAN	interferon-induced protein with	327					negative regulation of protein binding|response to virus|type I interferon-mediated signaling pathway		protein binding			ovary(1)|skin(1)	2		Colorectal(252;0.0161)				GAAGAAAGCTGATGAGGCCAA	0.418		NaN											0	0	0	0.001168	0	6	58									
KIF20B	9585	broad.mit.edu	37	10	91469117	91469117	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:91469117C>T	uc001kgs.1	+	4	322	c.250C>T	c.(250-252)CTG>TTG	p.L84L	KIF20B_uc001kgr.1_Silent_p.L84L	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	84	Kinesin-motor.				cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						TGTGCATATTCTGGATTCACA	0.348		NaN											0	0	0	0.01441	0	61	44									
SORBS1	10580	broad.mit.edu	37	10	97096663	97096663	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:97096663G>A	uc001kkp.2	-	28	3299	c.3254C>T	c.(3253-3255)TCA>TTA	p.S1085L	SORBS1_uc001kkk.2_Intron|SORBS1_uc001kkl.2_Intron|SORBS1_uc001kkn.2_Intron|SORBS1_uc001kkm.2_Intron|SORBS1_uc001kko.2_Intron|SORBS1_uc001kkq.2_Intron|SORBS1_uc001kkr.2_Intron|SORBS1_uc001kks.2_Intron|SORBS1_uc001kkt.2_Intron|SORBS1_uc001kku.2_Intron|SORBS1_uc001kkv.2_Intron|SORBS1_uc001kkw.2_Missense_Mutation_p.S1039L|SORBS1_uc010qoe.1_Intron	NM_001034954	NP_001030126	Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1 isoform 3	1085					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		GTGGATGCCTGAAGATGGCGT	0.562		NaN											0	0	0	0.000602	0	5	27									
SORBS1	10580	broad.mit.edu	37	10	97101052	97101052	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:97101052G>A	uc001kkp.2	-	26	2705	c.2660C>T	c.(2659-2661)TCC>TTC	p.S887F	SORBS1_uc001kkk.2_Missense_Mutation_p.S381F|SORBS1_uc001kkl.2_Missense_Mutation_p.S489F|SORBS1_uc001kkn.2_Missense_Mutation_p.S652F|SORBS1_uc001kkm.2_Missense_Mutation_p.S687F|SORBS1_uc001kko.2_Missense_Mutation_p.S909F|SORBS1_uc001kkq.2_Missense_Mutation_p.S738F|SORBS1_uc001kkr.2_Missense_Mutation_p.S593F|SORBS1_uc001kks.2_Missense_Mutation_p.S537F|SORBS1_uc001kkt.2_RNA|SORBS1_uc001kku.2_Missense_Mutation_p.S634F|SORBS1_uc001kkv.2_Missense_Mutation_p.S669F|SORBS1_uc001kkw.2_Missense_Mutation_p.S841F|SORBS1_uc010qoe.1_Missense_Mutation_p.S602F	NM_001034954	NP_001030126	Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1 isoform 3	887	SH3 2.				focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		CTTTCTGAAGGACATTTCTAC	0.468		NaN											0	0	0	0.001168	0	6	98									
C10orf12	26148	broad.mit.edu	37	10	98742417	98742417	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:98742417G>C	uc001kmv.2	+	1	1377	c.1270G>C	c.(1270-1272)GAG>CAG	p.E424Q	C10orf12_uc009xvg.1_Missense_Mutation_p.E734Q	NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	424										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		TGCTGAGGTTGAGTCTGGAGA	0.512		NaN											0	0	0	0.008291	0	10	150									
FAM178A	55719	broad.mit.edu	37	10	102689105	102689105	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:102689105G>T	uc001krt.3	+	7	2616	c.2074G>T	c.(2074-2076)GAC>TAC	p.D692Y	FAM178A_uc001krs.2_Missense_Mutation_p.D692Y	NM_018121	NP_060591	Q8IX21	F178A_HUMAN	hypothetical protein LOC55719 isoform 1	692											0						ACTACAAGAAGACATAAGGCA	0.363		NaN											1	0	1.5739e-10	0.004007	1.67292e-10	16	10									
SEMA4G	57715	broad.mit.edu	37	10	102740934	102740934	+	Silent	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:102740934G>C	uc001krw.1	+	13	2037	c.1653G>C	c.(1651-1653)CTG>CTC	p.L551L	SEMA4G_uc001krv.2_RNA|SEMA4G_uc001krx.2_Silent_p.L551L|MRPL43_uc001kry.1_Intron|MRPL43_uc010qpu.1_Intron	NM_017893	NP_060363	Q9NTN9	SEM4G_HUMAN	semaphorin 4G	546	Extracellular (Potential).|PSI.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)	1		Colorectal(252;0.234)		Epithelial(162;3.71e-09)|all cancers(201;2.1e-07)		GGACAGCACTGATACAGGACA	0.473		NaN											0	0	0	0.000602	0	5	35									
SFXN4	119559	broad.mit.edu	37	10	120923669	120923669	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr10:120923669C>G	uc001leb.2	-	2	196	c.151G>C	c.(151-153)GAT>CAT	p.D51H	SFXN4_uc001ldz.2_5'UTR|SFXN4_uc001lea.2_RNA	NM_213649	NP_998814	Q6P4A7	SFXN4_HUMAN	sideroflexin 4	51					iron ion homeostasis	integral to membrane|mitochondrial membrane	cation transmembrane transporter activity			ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0261)		TTTGTAGGATCTAATAATTCT	0.318		NaN											0	0	0	0.01441	0	49	30									
PSMA1	5682	broad.mit.edu	37	11	14529258	14529258	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:14529258C>T	uc001mlk.2	-	9	825	c.679G>A	c.(679-681)GAT>AAT	p.D227N	PSMA1_uc001mll.2_Missense_Mutation_p.D233N|PSMA1_uc010rcp.1_RNA|PSMA1_uc001mlj.2_Missense_Mutation_p.D202N	NM_002786	NP_002777	P25786	PSA1_HUMAN	proteasome alpha 1 subunit isoform 2	227					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|polysome|proteasome core complex, alpha-subunit complex	protein binding|RNA binding|threonine-type endopeptidase activity			upper_aerodigestive_tract(1)|skin(1)	2						GACACATCATCATCATCATAG	0.353		NaN											0	0	0	0.007291	0	26	21									
INSC	387755	broad.mit.edu	37	11	15199878	15199878	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:15199878A>C	uc001mly.2	+	5	651	c.605A>C	c.(604-606)CAG>CCG	p.Q202P	INSC_uc001mlz.2_Missense_Mutation_p.Q155P|INSC_uc001mma.2_Missense_Mutation_p.Q155P|INSC_uc010rcs.1_Missense_Mutation_p.Q155P|INSC_uc001mmb.2_Missense_Mutation_p.Q155P|INSC_uc001mmc.2_Missense_Mutation_p.Q155P	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	202					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						AGGTGCCTTCAGGTTGAGAAT	0.572		NaN											0	0	0	0.012213	0	31	15									
SPTY2D1	144108	broad.mit.edu	37	11	18636604	18636604	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:18636604G>C	uc001moy.2	-	3	1433	c.1217C>G	c.(1216-1218)TCA>TGA	p.S406*	SPTY2D1_uc010rdi.1_Nonsense_Mutation_p.S406*	NM_194285	NP_919261	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1	406	Ser-rich.									breast(1)	1						CTCAGGTCCTGAGCTGGAGCT	0.592		NaN											0	0	0	0.008291	0	11	70									
SLC17A6	57084	broad.mit.edu	37	11	22360119	22360119	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:22360119G>A	uc001mqk.2	+	1	453	c.40G>A	c.(40-42)GAG>AAG	p.E14K		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	14	Cytoplasmic (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						CCCAGGAAAAGAGGGGCTAAA	0.438		NaN											0	0	0	0.00499	0	14	24									
LUZP2	338645	broad.mit.edu	37	11	24759813	24759813	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:24759813G>A	uc001mqs.2	+	4	532	c.298G>A	c.(298-300)GAG>AAG	p.E100K	LUZP2_uc009yif.2_Missense_Mutation_p.E14K|LUZP2_uc009yig.2_Missense_Mutation_p.E100K	NM_001009909	NP_001009909	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2 precursor	100	Potential.					extracellular region				ovary(1)|skin(1)	2						TCAGCTTAAGGAGACATCAGA	0.363		NaN											0	0	0	0.00308	0	6	20									
COMMD9	29099	broad.mit.edu	37	11	36302292	36302292	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:36302292G>A	uc001mwn.3	-	2	184	c.147C>T	c.(145-147)AGC>AGT	p.S49S	COMMD9_uc009ykj.2_Intron|COMMD9_uc010rfb.1_Silent_p.S49S	NM_014186	NP_054905	Q9P000	COMD9_HUMAN	COMM domain containing 9 isoform 1	49										ovary(1)	1	all_lung(20;0.211)	all_hematologic(20;0.107)				TCACAGACAAGCTGGAACATG	0.468		NaN											0	0	0	0.001168	0	6	68									
ACCS	84680	broad.mit.edu	37	11	44098828	44098828	+	Splice_Site	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:44098828G>A	uc009yks.1	+	7	701	c.557_splice	c.e7-1	p.E186_splice	EXT2_uc010rfo.1_Intron|ACCS_uc010rfm.1_Intron|ACCS_uc010rfn.1_Splice_Site|ACCS_uc001mxx.2_Splice_Site_p.E186_splice	NM_001127219	NP_001120691	Q96QU6	1A1L1_HUMAN	1-aminocyclopropane-1-carboxylate synthase								1-aminocyclopropane-1-carboxylate synthase activity|protein homodimerization activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			breast(2)|ovary(1)|lung(1)	4						CCTGCCCCCAGAGGCTTTCCT	0.577		NaN											0	0	0	0.012319	0	21	91									
OR5T1	390155	broad.mit.edu	37	11	56043601	56043601	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:56043601G>A	uc001nio.1	+	1	487	c.487G>A	c.(487-489)GCT>ACT	p.A163T		NM_001004745	NP_001004745	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T,	163	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)	3	Esophageal squamous(21;0.00448)					TTCCTATGTTGCTAGCATTTT	0.428		NaN											0	0	0	0.01441	0	101	170									
PCNXL3	399909	broad.mit.edu	37	11	65393495	65393495	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:65393495C>T	uc001oey.2	+	20	3349	c.3349C>T	c.(3349-3351)CCG>TCG	p.P1117S	PCNXL3_uc009yqn.2_Missense_Mutation_p.P77S|PCNXL3_uc001oez.2_5'Flank	NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	1117						integral to membrane					0						CGTGCTGAAGCCGCTGGAGTA	0.647		NaN									OREG0021084	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	3	13									
SIPA1	6494	broad.mit.edu	37	11	65412521	65412521	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:65412521C>T	uc001ofb.2	+	5	1247	c.1080C>T	c.(1078-1080)TTC>TTT	p.F360F	SIPA1_uc010rom.1_Silent_p.F360F|SIPA1_uc001ofd.2_Silent_p.F360F	NM_006747	NP_006738	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated protein	360	Rap-GAP.				cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity				0						GACCGGCCTTCATGCAGTTTC	0.622		NaN											0	0	0	0.003954	0	25	107									
CCDC87	55231	broad.mit.edu	37	11	66360334	66360334	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:66360334C>T	uc001oiq.3	-	1	221	c.153G>A	c.(151-153)GCG>GCA	p.A51A	CCS_uc001oir.2_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	51										ovary(1)|skin(1)	2						CCGTCAGCTTCGCCAGAGGGA	0.677		NaN									OREG0021111	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	4	49									
SPTBN2	6712	broad.mit.edu	37	11	66456633	66456633	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:66456633G>A	uc001ojd.2	-	29	6040	c.5968C>T	c.(5968-5970)CAG>TAG	p.Q1990*	SPTBN2_uc001ojc.1_5'Flank	NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1990	Spectrin 16.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GCCTGCAGCTGAGACAGCTTC	0.632		NaN											0	0	0	0.009096	0	3	14									
SSH3	54961	broad.mit.edu	37	11	67075889	67075889	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:67075889G>C	uc001okj.2	+	10	1199	c.1021G>C	c.(1021-1023)GAG>CAG	p.E341Q	SSH3_uc001okk.2_RNA|SSH3_uc001okl.2_Missense_Mutation_p.E195Q	NM_017857	NP_060327	Q8TE77	SSH3_HUMAN	slingshot homolog 3	341	Tyrosine-protein phosphatase.				regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton|nucleus	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			CCAGGGCTCAGAGTGGAACGC	0.657		NaN											0	0	0	0.00308	0	7	23									
MRGPRF	116535	broad.mit.edu	37	11	68773711	68773711	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:68773711C>T	uc001ooo.3	-	3	434	c.67G>A	c.(67-69)GAG>AAG	p.E23K	MRGPRF_uc001oop.3_Missense_Mutation_p.E23K	NM_001098515	NP_001091985	Q96AM1	MRGRF_HUMAN	MAS-related GPR, member F	23	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TCCGGGGCCTCGCTCAGGCCA	0.667		NaN											0	0	0	0.004007	0	16	36									
TPCN2	219931	broad.mit.edu	37	11	68838873	68838873	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:68838873C>T	uc001oos.2	+	10	1061	c.945C>T	c.(943-945)TTC>TTT	p.F315F	TPCN2_uc009ysk.1_RNA|TPCN2_uc001oor.2_Silent_p.F230F|TPCN2_uc010rqg.1_Silent_p.F315F|TPCN2_uc001oot.2_5'Flank	NM_139075	NP_620714	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	315	Cytoplasmic (Potential).				cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			ACAGTCAGTTCCGGGGCTACC	0.597		NaN											0	0	0	0.009096	0	3	11									
PPFIA1	8500	broad.mit.edu	37	11	70200458	70200458	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:70200458G>A	uc001opo.2	+	17	2413	c.2215G>A	c.(2215-2217)GAA>AAA	p.E739K	PPFIA1_uc001opn.1_Missense_Mutation_p.E739K|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_RNA	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	739					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			CATAAAGTGTGAAACCTCCCC	0.532		NaN											0	0	0	0.000602	0	5	50									
C2CD3	26005	broad.mit.edu	37	11	73825601	73825601	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:73825601C>T	uc001ouu.2	-	10	1785	c.1558G>A	c.(1558-1560)GAA>AAA	p.E520K	C2CD3_uc001ouv.2_Missense_Mutation_p.E520K	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	520						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					TGGGCATCTTCTGGAGTTTCT	0.443		NaN											0	0	0	0.010504	0	19	83									
MYO7A	4647	broad.mit.edu	37	11	76892492	76892492	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:76892492C>T	uc001oyb.2	+	23	3033	c.2761C>T	c.(2761-2763)CGG>TGG	p.R921W	MYO7A_uc010rsl.1_Missense_Mutation_p.R921W|MYO7A_uc010rsm.1_Missense_Mutation_p.R910W|MYO7A_uc001oyc.2_Missense_Mutation_p.R921W|MYO7A_uc001oyd.2_Missense_Mutation_p.R261W|MYO7A_uc009yus.1_RNA|MYO7A_uc009yut.1_Missense_Mutation_p.R132W	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	921	Potential.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						GGCCGCTCGGCGGAAGAAGGA	0.617		NaN											0	0	0	0.001168	0	6	10									
C11orf82	220042	broad.mit.edu	37	11	82643638	82643638	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:82643638G>A	uc001ozt.2	+	6	1502	c.1258G>A	c.(1258-1260)GAA>AAA	p.E420K	C11orf82_uc010rsr.1_Missense_Mutation_p.E119K|C11orf82_uc010rss.1_Missense_Mutation_p.E119K|C11orf82_uc009yvd.2_Intron	NM_145018	NP_659455	Q8IXT1	NOXIN_HUMAN	nitric oxide-inducible gene protein	420					apoptosis|cell cycle arrest	cytoplasm|nucleus				ovary(2)	2						GCCATTCTCTGAAAGCCTGAA	0.443		NaN											0	0	0	0.004007	0	17	144									
CREBZF	58487	broad.mit.edu	37	11	85374910	85374910	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:85374910G>A	uc001pas.2	-	1	1273	c.1010C>T	c.(1009-1011)TCG>TTG	p.S337L	CREBZF_uc010rtc.1_RNA|CREBZF_uc010rtd.1_RNA	NM_001039618	NP_001034707	Q9NS37	ZHANG_HUMAN	HCF-binding transcription factor Zhangfei	337					negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|response to virus	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)				GAACTCCACCGACACCTTATC	0.562		NaN									OREG0021274	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010504	0	21	122									
SYTL2	54843	broad.mit.edu	37	11	85438975	85438975	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:85438975G>C	uc010rth.1	-	7	1699	c.1423C>G	c.(1423-1425)CAG>GAG	p.Q475E	SYTL2_uc010rtg.1_Missense_Mutation_p.Q476E|SYTL2_uc010rti.1_Missense_Mutation_p.Q475E|SYTL2_uc010rtj.1_Missense_Mutation_p.Q427E|SYTL2_uc009yvj.2_5'Flank|SYTL2_uc001pbd.2_5'Flank|SYTL2_uc001pbb.2_5'Flank|SYTL2_uc001pbc.2_5'Flank|SYTL2_uc010rtf.1_Missense_Mutation_p.Q333E	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	475					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		CCTGGCACCTGAGATGGCTCA	0.453		NaN											0	0	0	0.00499	0	14	27									
SYTL2	54843	broad.mit.edu	37	11	85445719	85445719	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:85445719G>A	uc010rth.1	-	6	926	c.650C>T	c.(649-651)TCA>TTA	p.S217L	SYTL2_uc010rtg.1_Missense_Mutation_p.S218L|SYTL2_uc010rti.1_Missense_Mutation_p.S217L|SYTL2_uc010rtj.1_Missense_Mutation_p.S169L|SYTL2_uc001pbf.3_Missense_Mutation_p.S217L|SYTL2_uc010rtf.1_Missense_Mutation_p.S75L	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	217					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		AGTCTGCTTTGATTTCTCTAA	0.368		NaN											0	0	0	0.004878	0	35	66									
GRM5	2915	broad.mit.edu	37	11	88583124	88583124	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:88583124C>T	uc001pcq.2	-	2	1061	c.861G>A	c.(859-861)CTG>CTA	p.L287L	GRM5_uc009yvm.2_Silent_p.L287L	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	287	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	TCATGGCCATCAGCAGACCTC	0.517		NaN											0	0	0	0.012213	0	35	50									
HEPHL1	341208	broad.mit.edu	37	11	93821974	93821974	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:93821974C>G	uc001pep.2	+	12	2291	c.2134C>G	c.(2134-2136)CAG>GAG	p.Q712E	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	712	Plastocyanin-like 4.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				AGGCATGGGTCAGATCTATGA	0.502		NaN											0	0	0	0.004007	0	17	35									
PCSK7	9159	broad.mit.edu	37	11	117094889	117094889	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:117094889C>G	uc001pqr.2	-	8	1160	c.959G>C	c.(958-960)GGG>GCG	p.G320A		NM_004716	NP_004707	Q16549	PCSK7_HUMAN	proprotein convertase subtilisin/kexin type 7	320	Catalytic.|Extracellular (Potential).				peptide hormone processing	integral to Golgi membrane	serine-type endopeptidase activity				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|Epithelial(105;6.71e-05)|all cancers(92;0.000537)		AAAGATGCTCCCAAAGCCCTG	0.547		NaN	T	IGH@	MLCLS								0	0	0	0.00245	0	13	27									
ZNF202	7753	broad.mit.edu	37	11	123597577	123597577	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:123597577C>T	uc001pzd.1	-	9	1475	c.1075G>A	c.(1075-1077)GAG>AAG	p.E359K	ZNF202_uc001pzc.1_Missense_Mutation_p.E135K|ZNF202_uc001pze.1_Missense_Mutation_p.E359K|ZNF202_uc001pzf.1_Missense_Mutation_p.E359K	NM_003455	NP_003446	O95125	ZN202_HUMAN	zinc finger protein 202	359					lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		GGATTGTCCTCAAAGACTATT	0.433		NaN											0	0	0	0.01441	0	79	134									
OR8B12	219858	broad.mit.edu	37	11	124412979	124412979	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:124412979G>A	uc010sam.1	-	1	572	c.572C>T	c.(571-573)TCT>TTT	p.S191F		NM_001005195	NP_001005195	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B,	191	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		ATTCATGTAAGAGCTGTTGCA	0.458		NaN											0	0	0	0.013726	0	33	51									
ADAMTS15	170689	broad.mit.edu	37	11	130319039	130319039	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr11:130319039C>T	uc010scd.1	+	1	171	c.171C>T	c.(169-171)ATC>ATT	p.I57I		NM_139055	NP_620686	Q8TE58	ATS15_HUMAN	a disintegrin-like and metalloprotease	57					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|pancreas(1)|lung(1)|skin(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		TTTTTCAGATCACAGCATTTC	0.602		NaN											0	0	0	0.008291	0	11	76									
A2M	2	broad.mit.edu	37	12	9229990	9229990	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:9229990G>A	uc001qvk.1	-	27	3416	c.3303C>T	c.(3301-3303)CTC>CTT	p.L1101L	A2M_uc001qvj.1_Silent_p.L143L|A2M_uc009zgk.1_Silent_p.L951L	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	1101					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	TATAGGCGGAGAGGGTCACTT	0.453		NaN											0	0	0	0.001984	0	5	10									
PRB1	5542	broad.mit.edu	37	12	11506649	11506649	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:11506649G>A	uc001qzw.1	-	3	425	c.388C>T	c.(388-390)CAA>TAA	p.Q130*	PRB1_uc001qzu.1_Intron|PRB1_uc001qzv.1_Intron	NM_005039	NP_005030	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1 isoform 1	191	7.|15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].		Missing (in clone CP-4).|Missing (in clone CP-5).|Missing (in allele S).			extracellular region					0			OV - Ovarian serous cystadenocarcinoma(49;0.185)			GGGGGACCTTGAGGTCTGTTG	0.617		NaN											0	0	0	0.01441	0	46	693									
SLCO1C1	53919	broad.mit.edu	37	12	20903661	20903661	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:20903661C>T	uc001rej.3	+	15	2206	c.1851C>T	c.(1849-1851)CTC>CTT	p.L617L	SLCO1C1_uc010sii.1_Silent_p.L617L|SLCO1C1_uc010sij.1_Silent_p.L568L|SLCO1C1_uc009zip.2_Silent_p.L451L|SLCO1C1_uc001rei.2_Silent_p.L617L|SLCO1C1_uc010sik.1_Silent_p.L499L	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	617	Extracellular (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					CTTCATGCCTCAAATGGGGAT	0.363		NaN											0	0	0	0.006122	0	17	70									
ADAMTS20	80070	broad.mit.edu	37	12	43825236	43825236	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:43825236G>A	uc010skx.1	-	22	3160	c.3160C>T	c.(3160-3162)CAC>TAC	p.H1054Y	ADAMTS20_uc001rno.1_Missense_Mutation_p.H208Y|ADAMTS20_uc001rnp.1_Missense_Mutation_p.H208Y	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1054	TSP type-1 5.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TCACTCAAGTGATCTACATTC	0.428		NaN											0	0	0	0.01441	0	63	40									
ADAMTS20	80070	broad.mit.edu	37	12	43944794	43944794	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:43944794G>A	uc010skx.1	-	2	371	c.371C>T	c.(370-372)TCG>TTG	p.S124L		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	124						proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GCGCAGGTCCGAGGGCCCTGC	0.667		NaN											0	0	0	0.010729	0	10	5									
SFRS2IP	9169	broad.mit.edu	37	12	46320089	46320089	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:46320089G>A	uc001rox.2	-	11	3682	c.3395C>T	c.(3394-3396)TCA>TTA	p.S1132L	SFRS2IP_uc001row.2_Missense_Mutation_p.S817L|SFRS2IP_uc001roy.1_Missense_Mutation_p.S1206L	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	1132					spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		TGTATCAAATGAGAACTCCTG	0.443		NaN											0	0	0	0.005443	0	27	83									
KRT4	3851	broad.mit.edu	37	12	53207850	53207850	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:53207850G>C	uc001saz.2	-	1	486	c.215C>G	c.(214-216)TCT>TGT	p.S72C		NM_002272	NP_002263	B4DRS2	B4DRS2_HUMAN	keratin 4	Error:Variant_position_missing_in_B4DRS2_after_alignment						keratin filament	structural molecule activity			ovary(4)|skin(2)	6						CATGGCTGCAGAGAGCGAGCT	0.627		NaN											0	0	0	0.006122	0	17	33									
KRT78	196374	broad.mit.edu	37	12	53242451	53242451	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:53242451G>A	uc001sbc.1	-	1	328	c.264C>T	c.(262-264)ATC>ATT	p.I88I		NM_173352	NP_775487	Q8N1N4	K2C78_HUMAN	keratin 5b	88	Head.					keratin filament	protein binding|structural molecule activity			ovary(2)	2						GATTCTGGTTGATGGTCACTT	0.622		NaN											0	0	0	0.003163	0	11	29									
RARG	5916	broad.mit.edu	37	12	53607319	53607319	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:53607319C>T	uc001sce.2	-	8	1464	c.979G>A	c.(979-981)GAG>AAG	p.E327K	RARG_uc001scd.2_Missense_Mutation_p.E316K|RARG_uc010sob.1_Missense_Mutation_p.E305K|RARG_uc001scf.2_Missense_Mutation_p.E327K|RARG_uc001scg.2_Missense_Mutation_p.E255K|RARG_uc010soc.1_Missense_Mutation_p.E206K|RARG_uc010sod.1_Missense_Mutation_p.E364K	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	327	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	AGCCCTGTCTCGGTGTCATCC	0.647		NaN									OREG0021862	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00333	0	25	17									
TRHDE	29953	broad.mit.edu	37	12	72956777	72956777	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:72956777G>C	uc001sxa.2	+	9	1894	c.1864G>C	c.(1864-1866)GAT>CAT	p.D622H		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	622	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						TTTTATCTATGATATCAGTGC	0.323		NaN											0	0	0	0.01441	0	58	41									
C12orf63	374467	broad.mit.edu	37	12	97157932	97157932	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:97157932C>T	uc001tet.1	+	26	3397	c.3319C>T	c.(3319-3321)CCT>TCT	p.P1107S		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	1107										skin(6)|ovary(1)	7						TTTTTAGCCTCCTCTCAGAAG	0.308		NaN											0	0	0	0.001168	0	6	23									
ATP2A2	488	broad.mit.edu	37	12	110778732	110778732	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:110778732G>C	uc001tqk.3	+	14	2593	c.2030G>C	c.(2029-2031)CGA>CCA	p.R677P	ATP2A2_uc001tql.3_Missense_Mutation_p.R677P|ATP2A2_uc010sxy.1_Missense_Mutation_p.R650P	NM_170665	NP_733765	P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, slow twitch 2 isoform	677	Cytoplasmic (By similarity).				ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			ovary(3)|skin(1)	4						TGTTTTGCTCGAGTTGAACCC	0.498		NaN											0	0	0	0.006214	0	9	24									
ARPC3	10094	broad.mit.edu	37	12	110874486	110874486	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:110874486G>A	uc001tqq.2	-	5	348	c.255C>T	c.(253-255)TGC>TGT	p.C85C		NM_005719	NP_005710	O15145	ARPC3_HUMAN	actin related protein 2/3 complex subunit 3	85					cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cytoplasm	actin binding|structural constituent of cytoskeleton			ovary(1)	1						TTTTGGAATTGCACTGGaaaa	0.254		NaN											0	0	0	0.00308	0	7	27									
DDX54	79039	broad.mit.edu	37	12	113599123	113599123	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:113599123C>A	uc001tup.2	-	19	2393	c.2365G>T	c.(2365-2367)GAC>TAC	p.D789Y	DDX54_uc001tuq.3_Missense_Mutation_p.D789Y	NM_024072	NP_076977	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	789					estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			skin(2)|central_nervous_system(1)	3						CCTCGCCGGTCAGATGCCCCT	0.577		NaN											1	0	9.16793e-09	0.00499	9.64887e-09	15	37									
EP400	57634	broad.mit.edu	37	12	132445298	132445298	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:132445298C>T	uc001ujn.2	+	1	169	c.134C>T	c.(133-135)TCA>TTA	p.S45L	EP400_uc001ujl.2_Missense_Mutation_p.S45L|EP400_uc001ujm.2_Missense_Mutation_p.S45L|EP400_uc001ujj.1_Missense_Mutation_p.S45L|EP400_uc001ujk.2_Missense_Mutation_p.S45L	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	45					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TTCGCTCCCTCAGCAAGCCCG	0.652		NaN											0	0	0	0.004007	0	16	12									
ZNF10	7556	broad.mit.edu	37	12	133732614	133732614	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:133732614G>C	uc009zzb.2	+	5	1229	c.782G>C	c.(781-783)AGA>ACA	p.R261T	ZNF268_uc010tbv.1_Intron|ZNF10_uc001ulq.2_Missense_Mutation_p.R261T	NM_015394	NP_056209	P21506	ZNF10_HUMAN	zinc finger protein 10	261				Missing (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		GGCATACATAGAGAGAAACCC	0.393		NaN											0	0	0	0.013537	0	12	51									
TPTE2	93492	broad.mit.edu	37	13	20039688	20039688	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:20039688G>A	uc001umd.2	-	9	740	c.529C>T	c.(529-531)CGA>TGA	p.R177*	TPTE2_uc009zzk.2_RNA|TPTE2_uc009zzl.2_Nonsense_Mutation_p.R66*|TPTE2_uc001ume.2_Nonsense_Mutation_p.R100*|TPTE2_uc009zzm.2_5'UTR|TPTE2_uc010tcm.1_RNA	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	177						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		CGTAGAAGTCGAACTAAATGT	0.289		NaN											0	0	0	0.00499	0	17	22									
ATP12A	479	broad.mit.edu	37	13	25283562	25283562	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:25283562C>T	uc001upp.2	+	18	2741	c.2554C>T	c.(2554-2556)CGC>TGC	p.R852C	ATP12A_uc010aaa.2_Missense_Mutation_p.R858C	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	852	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	CAGGAAGCCTCGCCACAAGAA	0.557		NaN											0	0	0	0.001855	0	12	58									
BRCA2	675	broad.mit.edu	37	13	32915264	32915264	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:32915264G>A	uc001uub.1	+	11	6999	c.6772G>A	c.(6772-6774)GAA>AAA	p.E2258K		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2258					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TACATGTCCCGAAAATGAGGA	0.378		NaN	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.00499	0	18	179									
COG3	83548	broad.mit.edu	37	13	46103990	46103990	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:46103990G>A	uc001vak.2	+	21	2396	c.2295G>A	c.(2293-2295)TTG>TTA	p.L765L	COG3_uc010tfv.1_Silent_p.L602L|COG3_uc010aci.2_Silent_p.L541L	NM_031431	NP_113619	Q96JB2	COG3_HUMAN	component of golgi transport complex 3	765					ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein glycosylation|protein localization to organelle|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	cis-Golgi network|Golgi cisterna membrane|Golgi transport complex	protein binding|protein transporter activity			breast(1)|skin(1)	2		Lung NSC(96;0.000145)|Breast(56;0.000596)|Prostate(109;0.00438)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000124)		CTGTGACATTGAGAAGTATGT	0.388		NaN											0	0	0	0.006999	0	38	25									
UTP14C	9724	broad.mit.edu	37	13	52605165	52605165	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:52605165C>T	uc001vgb.2	+	2	2760	c.2225C>T	c.(2224-2226)TCA>TTA	p.S742L	UTP14C_uc001vgc.2_RNA	NM_021645	NP_067677	Q5TAP6	UT14C_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	742					cell differentiation|meiosis|multicellular organismal development|rRNA processing|spermatogenesis	nucleolus|small-subunit processome				ovary(3)|large_intestine(1)|breast(1)	5		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.3e-08)		CAGTCTTCCTCAAGGTCAGAC	0.478		NaN											0	0	0	0.004007	0	15	143									
KLF5	688	broad.mit.edu	37	13	73649905	73649905	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:73649905G>A	uc001vje.2	+	4	1579	c.1255G>A	c.(1255-1257)GAG>AAG	p.E419K	KLF5_uc001vjd.2_Missense_Mutation_p.E328K	NM_001730	NP_001721	Q13887	KLF5_HUMAN	Kruppel-like factor 5	419	C2H2-type 2.				transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|pancreas(1)	3		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		GCGATCGGATGAGCTGACCCG	0.592		NaN											0	0	0	0.00308	0	7	54									
GRTP1	79774	broad.mit.edu	37	13	114009747	114009747	+	Silent	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:114009747G>T	uc001vtn.2	-	3	328	c.231C>A	c.(229-231)GTC>GTA	p.V77V	GRTP1_uc010tkb.1_Translation_Start_Site|GRTP1_uc010tkc.1_Silent_p.V77V|GRTP1_uc010agv.1_RNA	NM_024719	NP_078995	Q5TC63	GRTP1_HUMAN	growth hormone regulated TBC protein 1	77	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0314)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0978)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			GCACCATCCAGACGCGGGCAC	0.662		NaN											1	0	4.96729e-08	0.008871	5.19381e-08	21	27									
ADPRHL1	113622	broad.mit.edu	37	13	114077230	114077230	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:114077230G>A	uc001vtq.1	-	7	1059	c.972C>T	c.(970-972)CTC>CTT	p.L324L	ADPRHL1_uc001vtp.1_Silent_p.L242L	NM_138430	NP_612439	Q8NDY3	ARHL1_HUMAN	ADP-ribosylhydrolase like 1 isoform 1	324					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.0195)|GBM - Glioblastoma multiforme(44;0.116)			CTTTGGGAACGAGGTCCAGGC	0.617		NaN											0	0	0	0.001984	0	6	83									
TMCO3	55002	broad.mit.edu	37	13	114150069	114150069	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:114150069C>T	uc001vtu.3	+	2	534	c.173C>T	c.(172-174)TCA>TTA	p.S58L	TMCO3_uc001vtt.3_Missense_Mutation_p.S58L	NM_017905	NP_060375	Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	58						integral to membrane	solute:hydrogen antiporter activity				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)			AGGAAGCTCTCAGGGCTTCTC	0.582		NaN											0	0	0	0.010729	0	12	18									
ZNF828	283489	broad.mit.edu	37	13	115090645	115090645	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:115090645C>T	uc010ahb.2	+	3	1657	c.1328C>T	c.(1327-1329)TCA>TTA	p.S443L	ZNF828_uc001vuv.2_Missense_Mutation_p.S443L|ZNF828_uc010tko.1_Missense_Mutation_p.S443L	NM_001164144	NP_001157616	Q96JM3	ZN828_HUMAN	zinc finger protein 828	443	Mediates interaction with MAD2L2.|Pro-rich.				attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|protein localization to kinetochore|protein localization to microtubule|sister chromatid biorientation	condensed chromosome kinetochore|cytoplasm|nucleus|spindle	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_epithelial(44;0.122)|all_lung(25;0.123)	BRCA - Breast invasive adenocarcinoma(86;0.104)	OV - Ovarian serous cystadenocarcinoma(48;0.193)|Epithelial(10;0.197)		AGAAAACCCTCAGGGTCACCA	0.537		NaN											0	0	0	0.01441	0	72	151									
JUB	84962	broad.mit.edu	37	14	23445703	23445703	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:23445703C>G	uc001whz.2	-	4	1577	c.1201G>C	c.(1201-1203)GAG>CAG	p.E401Q	JUB_uc001why.2_5'UTR	NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	401	LIM zinc-binding 2.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		CAGCATTTCTCAGCTGCCTCC	0.478		NaN											0	0	0	0.01441	0	49	188									
C14orf93	60686	broad.mit.edu	37	14	23456450	23456450	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:23456450C>G	uc001wib.1	-	7	1901	c.1591G>C	c.(1591-1593)GAA>CAA	p.E531Q	C14orf93_uc001wic.1_Missense_Mutation_p.E351Q|C14orf93_uc001wid.1_Missense_Mutation_p.E531Q|C14orf93_uc001wig.2_Missense_Mutation_p.E531Q|C14orf93_uc001wih.2_Missense_Mutation_p.E531Q|C14orf93_uc001wie.2_Missense_Mutation_p.E531Q|C14orf93_uc001wia.3_Missense_Mutation_p.E491Q|C14orf93_uc001wif.2_Missense_Mutation_p.E351Q	NM_021944	NP_068763	Q9H972	CN093_HUMAN	hypothetical protein LOC60686 precursor	531						extracellular region				ovary(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.0127)		ACCTTGATTTCAATGAATGAG	0.483		NaN									OREG0022593	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001168	0	5	35									
PABPN1	8106	broad.mit.edu	37	14	23792641	23792641	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:23792641C>T	uc001wjk.2	+	4	1872	c.590C>T	c.(589-591)TCA>TTA	p.S197L	PABPN1_uc001wjh.3_Missense_Mutation_p.S224L|PABPN1_uc001wjj.2_Missense_Mutation_p.S197L	NM_004643	NP_004634	Q86U42	PABP2_HUMAN	poly(A) binding protein, nuclear 1	197	Necessary for homooligomerization.|RRM.				modification by virus of host mRNA processing|mRNA 3'-end processing|muscle contraction|nuclear mRNA splicing, via spliceosome|poly(A)+ mRNA export from nucleus|termination of RNA polymerase II transcription|viral infectious cycle	cytoplasm|nucleoplasm|ribonucleoprotein complex	nucleotide binding|protein binding|RNA binding			ovary(2)	2	all_cancers(95;6.69e-06)			GBM - Glioblastoma multiforme(265;0.00643)		GGCTGTGGTTCAGTCAACCGT	0.428		NaN											0	0	0	0.010729	0	9	78									
ADCY4	196883	broad.mit.edu	37	14	24799114	24799114	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:24799114G>A	uc001wov.2	-	8	1175	c.1169C>T	c.(1168-1170)TCA>TTA	p.S390L	ADCY4_uc001wow.2_Missense_Mutation_p.S390L|ADCY4_uc010toh.1_Missense_Mutation_p.S76L|ADCY4_uc001wox.2_Missense_Mutation_p.S390L|ADCY4_uc001woy.2_Missense_Mutation_p.S390L	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	390	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		GACATCATGTGACCAAACGTC	0.597		NaN											0	0	0	0.010504	0	20	112									
G2E3	55632	broad.mit.edu	37	14	31074728	31074728	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:31074728G>C	uc001wqk.2	+	11	1182	c.1028G>C	c.(1027-1029)AGA>ACA	p.R343T	G2E3_uc010tpe.1_Intron|G2E3_uc010tpf.1_Missense_Mutation_p.R297T	NM_017769	NP_060239	Q7L622	G2E3_HUMAN	G2/M-phase specific E3 ubiquitin ligase	343					apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						AGCAAATTTAGAAGAAATGTA	0.269		NaN											0	0	0	0.00308	0	8	28									
NID2	22795	broad.mit.edu	37	14	52520475	52520475	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:52520475G>T	uc001wzo.2	-	5	1485	c.1251C>A	c.(1249-1251)AAC>AAA	p.N417K	NID2_uc010tqs.1_Missense_Mutation_p.N417K|NID2_uc010tqt.1_Missense_Mutation_p.N417K|NID2_uc001wzp.2_Missense_Mutation_p.N417K	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	417						basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					GGATGCTTCCGTTTTCGGGGT	0.557		NaN											1	0	1.5548e-18	0.005443	1.69471e-18	26	83									
SAMD4A	23034	broad.mit.edu	37	14	55169071	55169071	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:55169071G>A	uc001xbb.2	+	2	486	c.485G>A	c.(484-486)CGA>CAA	p.R162Q	SAMD4A_uc001xba.2_Missense_Mutation_p.R162Q|SAMD4A_uc001xbc.2_Missense_Mutation_p.R162Q|SAMD4A_uc001xbf.1_RNA|SAMD4A_uc001xbe.2_Missense_Mutation_p.R62Q	NM_015589	NP_056404	Q9UPU9	SMAG1_HUMAN	sterile alpha motif domain containing 4 isoform	163					positive regulation of translation	cell junction|cytoplasm|dendrite|synapse|synaptosome	translation repressor activity				0						GGCCAGAACCGAGGCCGCTCA	0.512		NaN											0	0	0	0.00632	0	27	61									
DLGAP5	9787	broad.mit.edu	37	14	55618550	55618550	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:55618550C>G	uc001xbs.2	-	17	2448	c.2231G>C	c.(2230-2232)GGA>GCA	p.G744A	DLGAP5_uc001xbt.2_Missense_Mutation_p.G744A	NM_014750	NP_055565	Q15398	DLGP5_HUMAN	discs large homolog 7 isoform a	744					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			ovary(1)|skin(1)	2						ATCTGAAATTCCTTCTTTTTT	0.368		NaN											0	0	0	0.003163	0	16	67									
C14orf37	145407	broad.mit.edu	37	14	58604778	58604778	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:58604778G>C	uc001xdc.2	-	2	1410	c.1299C>G	c.(1297-1299)TTC>TTG	p.F433L	C14orf37_uc010tro.1_Missense_Mutation_p.F471L|C14orf37_uc001xdd.2_Missense_Mutation_p.F433L|C14orf37_uc001xde.2_Missense_Mutation_p.F433L	NM_001001872	NP_001001872	Q86TY3	CN037_HUMAN	hypothetical protein LOC145407 precursor	433	Extracellular (Potential).					integral to membrane	binding				0						TGGTTTCTAAGAAAAACAGGG	0.398		NaN											0	0	0	0.00245	0	13	93									
C14orf37	145407	broad.mit.edu	37	14	58604814	58604814	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:58604814G>A	uc001xdc.2	-	2	1374	c.1263C>T	c.(1261-1263)TTC>TTT	p.F421F	C14orf37_uc010tro.1_Silent_p.F459F|C14orf37_uc001xdd.2_Silent_p.F421F|C14orf37_uc001xde.2_Silent_p.F421F	NM_001001872	NP_001001872	Q86TY3	CN037_HUMAN	hypothetical protein LOC145407 precursor	421	Extracellular (Potential).					integral to membrane	binding				0						TGGATTCCGTGAAGTCTCCCG	0.438		NaN											0	0	0	0.013537	0	12	75									
PLEKHG3	26030	broad.mit.edu	37	14	65198192	65198192	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:65198192C>T	uc001xho.1	+	8	1232	c.963C>T	c.(961-963)TTC>TTT	p.F321F	PLEKHG3_uc001xhn.1_Silent_p.F265F|PLEKHG3_uc001xhp.2_Silent_p.F321F|PLEKHG3_uc010aqh.1_5'UTR	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	321	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		GGACCTTTTTCCTCTTTGACA	0.567		NaN											0	0	0	0.005443	0	26	55									
VIPAR	63894	broad.mit.edu	37	14	77916080	77916080	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:77916080C>T	uc001xtt.1	-	6	697	c.359G>A	c.(358-360)GGA>GAA	p.G120E	VIPAR_uc001xtu.1_Missense_Mutation_p.G120E|VIPAR_uc010tvj.1_Missense_Mutation_p.G71E|VIPAR_uc001xtv.1_Missense_Mutation_p.G120E	NM_022067	NP_071350	Q9H9C1	VIPAR_HUMAN	hypothetical protein LOC63894	120					endosome to lysosome transport|intracellular protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	early endosome|late endosome|recycling endosome	protein binding			central_nervous_system(1)	1						CTGGAAACTTCCAGGTCTAGT	0.443		NaN											0	0	0	0.010771	0	44	72									
NRXN3	9369	broad.mit.edu	37	14	79269994	79269994	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:79269994G>C	uc001xun.2	+	6	1448	c.957G>C	c.(955-957)ATG>ATC	p.M319I	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Missense_Mutation_p.M453I	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	692	Laminin G-like 4.|Extracellular (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		ATGGTAGCATGTACATGAAGA	0.498		NaN											0	0	0	0.01441	0	49	75									
GALC	2581	broad.mit.edu	37	14	88450815	88450815	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:88450815G>A	uc001xvt.2	-	5	904	c.505C>T	c.(505-507)CAG>TAG	p.Q169*	GALC_uc010tvx.1_Nonsense_Mutation_p.Q143*|GALC_uc010tvy.1_Nonsense_Mutation_p.Q146*|GALC_uc010tvz.1_Nonsense_Mutation_p.Q113*|GALC_uc001xvu.1_Nonsense_Mutation_p.Q169*	NM_000153	NP_000144	P54803	GALC_HUMAN	galactosylceramidase isoform a precursor	169					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity				0						GCAGTCAGCTGAAGATTGACA	0.453		NaN											0	0	0	0.008871	0	18	32									
ZC3H14	79882	broad.mit.edu	37	14	89034385	89034385	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:89034385G>A	uc001xww.2	+	3	307	c.82G>A	c.(82-84)GAA>AAA	p.E28K	ZC3H14_uc010twd.1_Missense_Mutation_p.E28K|ZC3H14_uc010twe.1_Missense_Mutation_p.E28K|ZC3H14_uc001xwx.2_Missense_Mutation_p.E28K|ZC3H14_uc010twf.1_5'UTR|ZC3H14_uc001xwy.2_5'UTR	NM_024824	NP_079100	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14 isoform 1	28						cytoplasm|cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			ovary(2)|skin(1)	3						TTAAATAGATGAAGAACTTCC	0.363		NaN											0	0	0	0.00308	0	8	36									
C14orf143	90141	broad.mit.edu	37	14	90416473	90416473	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:90416473G>A	uc001xxt.2	-	3	270	c.185C>T	c.(184-186)TCT>TTT	p.S62F	C14orf143_uc001xxs.2_Missense_Mutation_p.S38F|C14orf143_uc001xxv.1_RNA|C14orf143_uc001xxw.1_Missense_Mutation_p.S38F|C14orf143_uc001xxx.1_Missense_Mutation_p.S62F	NM_145231	NP_660274	Q9BUY7	EFC11_HUMAN	hypothetical protein LOC90141	62							calcium ion binding				0		all_cancers(154;0.136)		Epithelial(152;0.194)		AGACATCACAGAATCCACTTC	0.254		NaN											0	0	0	0.00308	0	6	14									
PSMC1	5700	broad.mit.edu	37	14	90735763	90735763	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:90735763G>C	uc001xyf.2	+	9	952	c.904G>C	c.(904-906)GAG>CAG	p.E302Q	PSMC1_uc001xyg.2_Missense_Mutation_p.E229Q|PSMC1_uc001xyh.2_Missense_Mutation_p.E229Q	NM_002802	NP_002793	P62191	PRS4_HUMAN	proteasome 26S ATPase subunit 1	302					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0		all_cancers(154;0.142)		COAD - Colon adenocarcinoma(157;0.21)		TTCTGGTGGTGAGAGAGAAAT	0.418		NaN											0	0	0	0.001855	0	13	77									
RAGE	5891	broad.mit.edu	37	14	102749865	102749865	+	Silent	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:102749865C>G	uc001ylm.2	-	2	298	c.72G>C	c.(70-72)CTG>CTC	p.L24L	RAGE_uc010txv.1_Silent_p.L24L|RAGE_uc001yln.2_5'UTR	NM_014226	NP_055041	Q9UQ07	MOK_HUMAN	MAPK/MAK/MRK overlapping kinase	24	Protein kinase.				signal transduction	Golgi apparatus	ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						TTCCATCTCTCAGGCTTTGCA	0.358		NaN											0	0	0	0.009535	0	28	42									
CINP	51550	broad.mit.edu	37	14	102822155	102822155	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:102822155C>T	uc001ylv.1	-	3	321	c.256G>A	c.(256-258)GAG>AAG	p.E86K	CINP_uc001ylu.1_RNA	NM_032630	NP_116019	Q9BW66	CINP_HUMAN	cyclin-dependent kinase 2-interacting protein	86	Potential.				cell cycle|cell division|DNA repair|DNA replication	nucleus	protein binding			large_intestine(1)	1						TCCAGTTCCTCGTTATATTCC	0.443		NaN											0	0	0	0.004007	0	16	74									
AKT1	207	broad.mit.edu	37	14	105243078	105243078	+	Silent	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:105243078G>T	uc001ypk.2	-	4	759	c.205C>A	c.(205-207)CGG>AGG	p.R69R	INF2_uc010tyi.1_Intron|AKT1_uc001ypl.2_Silent_p.R69R|AKT1_uc010axa.2_Silent_p.R69R|AKT1_uc001ypm.2_Silent_p.R69R|AKT1_uc001ypn.2_Silent_p.R69R|AKT1_uc010tyk.1_Silent_p.R7R	NM_005163	NP_005154	P31749	AKT1_HUMAN	AKT1 kinase	69	PH.				activation of pro-apoptotic gene products|activation-induced cell death of T cells|endocrine pancreas development|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen biosynthetic process|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|mRNA metabolic process|negative regulation of fatty acid beta-oxidation|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|nitric oxide biosynthetic process|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of blood vessel endothelial cell migration|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of establishment of protein localization in plasma membrane|positive regulation of fat cell differentiation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein autophosphorylation|protein import into nucleus, translocation|regulation of neuron projection development|regulation of translation|response to fluid shear stress|response to heat|response to UV-A|T cell costimulation	cytosol|nucleoplasm|plasma membrane	enzyme binding|identical protein binding|nitric-oxide synthase regulator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein serine/threonine kinase activity			breast(86)|urinary_tract(12)|thyroid(10)|lung(7)|endometrium(5)|large_intestine(4)|skin(4)|prostate(3)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|NS(1)	134		all_cancers(154;3.77e-06)|all_lung(585;3.24e-07)|all_epithelial(191;3.45e-05)|all_neural(303;0.0459)|Melanoma(154;0.155)	all cancers(16;0.000486)|OV - Ovarian serous cystadenocarcinoma(23;0.00647)|Epithelial(46;0.0153)|GBM - Glioblastoma multiforme(11;0.116)	all cancers(159;0.0107)|OV - Ovarian serous cystadenocarcinoma(161;0.0132)|Epithelial(152;0.243)	Adenosine triphosphate(DB00171)|Arsenic trioxide(DB01169)	GTGTTGGGCCGGGGCCGCTCC	0.672		1	Mis		breast|colorectal|ovarian|NSCLC								1	0	6.72482e-11	0.003163	7.17166e-11	14	35									
AHNAK2	113146	broad.mit.edu	37	14	105406884	105406884	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:105406884C>T	uc010axc.1	-	7	15024	c.14904G>A	c.(14902-14904)AAG>AAA	p.K4968K	AHNAK2_uc001ypx.2_Silent_p.K4868K	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4968						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CTGTTTCCTTCTTCGGGGACC	0.532		NaN											0	0	0	0.00245	0	13	23									
AHNAK2	113146	broad.mit.edu	37	14	105413428	105413428	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr14:105413428C>G	uc010axc.1	-	7	8480	c.8360G>C	c.(8359-8361)AGA>ACA	p.R2787T	AHNAK2_uc001ypx.2_Missense_Mutation_p.R2687T	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2787						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CAGCTTTGCTCTCGGGGCCTG	0.602		NaN											0	0	0	0.01441	0	119	221									
GABRB3	2562	broad.mit.edu	37	15	26793038	26793038	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:26793038G>C	uc001zaz.2	-	9	1466	c.1324C>G	c.(1324-1326)CTA>GTA	p.L442V	GABRB3_uc010uae.1_Missense_Mutation_p.L357V|GABRB3_uc001zba.2_Missense_Mutation_p.L442V|GABRB3_uc001zbb.2_Missense_Mutation_p.L498V	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	442	Cytoplasmic (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ACATCGGTTAGATCAGGTATT	0.458		NaN											0	0	0	0.003271	0	33	38									
GABRA5	2558	broad.mit.edu	37	15	27193135	27193135	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:27193135A>G	uc001zbd.1	+	12	1483	c.1144A>G	c.(1144-1146)ATG>GTG	p.M382V	GABRA5_uc001zbe.1_RNA	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	382	Cytoplasmic (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AACTGGGAAGATGTCTCACCC	0.433		NaN											0	0	0	0.000602	0	4	5									
AVEN	57099	broad.mit.edu	37	15	34159807	34159807	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:34159807G>A	uc001zhj.2	-	5	918	c.862C>T	c.(862-864)CTG>TTG	p.L288L		NM_020371	NP_065104	Q9NQS1	AVEN_HUMAN	cell death regulator aven	288					anti-apoptosis|apoptosis	endomembrane system|intracellular|membrane|membrane fraction	protein binding			kidney(1)	1		all_lung(180;1.78e-08)		all cancers(64;1.66e-15)|GBM - Glioblastoma multiforme(113;1.42e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0359)		TTAAGCAACAGATCTAGTTCT	0.488		NaN											0	0	0	0.010818	0	32	147									
DLL4	54567	broad.mit.edu	37	15	41228778	41228778	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:41228778C>T	uc001zng.1	+	9	1913	c.1593C>T	c.(1591-1593)GCC>GCT	p.A531A		NM_019074	NP_061947	Q9NR61	DLL4_HUMAN	delta-like 4 protein precursor	531	Helical; (Potential).				blood circulation|cell communication|cell differentiation|Notch receptor processing|Notch signaling pathway	integral to membrane|plasma membrane	calcium ion binding|Notch binding			breast(2)	2		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		CCTGGGTGGCCGTCTCGCTGG	0.672		NaN											0	0	0	0.00308	0	8	10									
TTBK2	146057	broad.mit.edu	37	15	43044650	43044650	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:43044650C>T	uc001zqo.2	-	14	3233	c.2794G>A	c.(2794-2796)GAT>AAT	p.D932N	TTBK2_uc010bcy.2_Missense_Mutation_p.D863N	NM_173500	NP_775771	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	932					cell death		ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|pancreas(1)|skin(1)	7		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		CTAACCATATCCTTCCGGGTT	0.428		NaN											0	0	0	0.003271	0	34	79									
ALDH1A2	8854	broad.mit.edu	37	15	58256149	58256149	+	Silent	SNP	G	G	A	rs114347273	by1000genomes	TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:58256149G>A	uc002aex.2	-	9	1078	c.1020C>T	c.(1018-1020)AGC>AGT	p.S340S	ALDH1A2_uc002aey.2_Silent_p.S302S|ALDH1A2_uc010ugv.1_Silent_p.S319S|ALDH1A2_uc010ugw.1_Silent_p.S311S|ALDH1A2_uc002aew.2_Silent_p.S244S	NM_003888	NP_003879	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1A2 isoform 1	340					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	CCCGCTCCACGCTTCTTCTCA	0.542		NaN											0	0	0	0.00632	0	26	84									
CELF6	60677	broad.mit.edu	37	15	72581516	72581516	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:72581516G>A	uc002auh.2	-	8	1303	c.993C>T	c.(991-993)TCC>TCT	p.S331S	uc002aug.2_Intron|CELF6_uc002auk.3_RNA|CELF6_uc010biv.1_RNA|CELF6_uc010biw.2_Silent_p.S218S|CELF6_uc010ukl.1_Silent_p.S215S|CELF6_uc010ukm.1_Silent_p.S331S|CELF6_uc002aui.2_Silent_p.S437S|CELF6_uc002auj.2_Silent_p.S218S	NM_052840	NP_443072	Q96J87	CELF6_HUMAN	bruno-like 6, RNA binding protein	331					mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)|central_nervous_system(1)|skin(1)	3						AGAGCGTGTCGGAGCCCGGCT	0.692		NaN											0	0	0	0.004672	0	3	5									
LOXL1	4016	broad.mit.edu	37	15	74240184	74240184	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:74240184G>A	uc002awc.1	+	5	1879	c.1543G>A	c.(1543-1545)GAC>AAC	p.D515N	LOXL1_uc002awd.1_RNA	NM_005576	NP_005567	Q08397	LOXL1_HUMAN	lysyl oxidase-like 1 preproprotein	515	Lysyl-oxidase like.				protein deamination	extracellular space	copper ion binding				0						CTACAATGCGGACATCGACTG	0.597		NaN											0	0	0	0.013537	0	10	96									
SCAPER	49855	broad.mit.edu	37	15	76673758	76673758	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:76673758G>T	uc002bby.2	-	27	3725	c.3666C>A	c.(3664-3666)TTC>TTA	p.F1222L	SCAPER_uc010bkr.2_Missense_Mutation_p.F530L|SCAPER_uc002bbx.2_Missense_Mutation_p.F976L|SCAPER_uc002bbz.1_Missense_Mutation_p.F1093L	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	1221						endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3						AGCTGTTGAAGAAACGTAAAC	0.428		NaN											1	0	2.17888e-05	0.006214	2.24894e-05	8	34									
SCAPER	49855	broad.mit.edu	37	15	76673922	76673922	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:76673922G>A	uc002bby.2	-	27	3561	c.3502C>T	c.(3502-3504)CCC>TCC	p.P1168S	SCAPER_uc010bkr.2_Missense_Mutation_p.P476S|SCAPER_uc002bbx.2_Missense_Mutation_p.P922S|SCAPER_uc002bbz.1_Missense_Mutation_p.P1039S	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	1167						endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3						AGCCCTGTGGGATCCTGGCGA	0.453		NaN											0	0	0	0.009096	0	4	13									
CPEB1	64506	broad.mit.edu	37	15	83295967	83295967	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:83295967C>T	uc002bit.2	-	2	484	c.347G>A	c.(346-348)CGA>CAA	p.R116Q	CPEB1_uc002biu.2_Missense_Mutation_p.R83Q|CPEB1_uc010uof.1_5'UTR|CPEB1_uc002biv.2_Missense_Mutation_p.R56Q	NM_001079533	NP_001073001	Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding	56					mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(143;0.229)			ATGAATTCCTCGGTTTATAGG	0.403		NaN											0	0	0	0.004656	0	25	76									
SV2B	9899	broad.mit.edu	37	15	91809817	91809817	+	Silent	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr15:91809817C>G	uc002bqv.2	+	6	1405	c.1014C>G	c.(1012-1014)TCC>TCG	p.S338S	SV2B_uc002bqt.2_Silent_p.S338S|SV2B_uc010uqv.1_Silent_p.S187S|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	338	Cytoplasmic (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			TTCAGGTTTCCAACATCAAAA	0.368		NaN											0	0	0	0.003163	0	14	41									
LUC7L	55692	broad.mit.edu	37	16	270656	270656	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:270656C>G	uc002cgc.1	-	3	358	c.247G>C	c.(247-249)GAA>CAA	p.E83Q	LUC7L_uc002cga.1_Missense_Mutation_p.E83Q|LUC7L_uc002cgd.1_RNA|LUC7L_uc002cge.1_Missense_Mutation_p.E83Q	NM_201412	NP_958815	Q9NQ29	LUC7L_HUMAN	LUC7-like isoform b	83							metal ion binding			central_nervous_system(1)	1		all_cancers(16;1.1e-06)|all_epithelial(16;2.71e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.0138)|all_lung(18;0.0306)				ACATCTAATTCAAAAAACAGG	0.308		NaN											0	0	0	0.01441	0	60	98									
NARFL	64428	broad.mit.edu	37	16	783368	783368	+	Silent	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:783368C>A	uc002cjr.2	-	7	765	c.753G>T	c.(751-753)CTG>CTT	p.L251L	NARFL_uc002cjp.2_Silent_p.L149L|NARFL_uc002cjq.2_Silent_p.L149L|NARFL_uc002cjs.2_Silent_p.L33L|NARFL_uc010uuq.1_5'Flank	NM_022493	NP_071938	Q9H6Q4	NARFL_HUMAN	nuclear prelamin A recognition factor-like	251					iron-sulfur cluster assembly|oxygen homeostasis|regulation of transcription, DNA-dependent|response to hypoxia		4 iron, 4 sulfur cluster binding|metal ion binding				0		Hepatocellular(780;0.0218)				TGGAGGCTTCCAGCTTTTTGT	0.557		NaN											1	0	0.00024832	0.009096	0.000253452	4	51									
IFT140	9742	broad.mit.edu	37	16	1618267	1618267	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:1618267G>A	uc002cmb.2	-	15	2083	c.1721C>T	c.(1720-1722)TCT>TTT	p.S574F	IFT140_uc002clz.2_Missense_Mutation_p.S225F	NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	574										ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				GCACCGCAGAGAAGCGATGCC	0.672		NaN											0	0	0	0.00308	0	6	18									
SRRM2	23524	broad.mit.edu	37	16	2817596	2817596	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:2817596G>A	uc002crk.2	+	11	7616	c.7067G>A	c.(7066-7068)AGA>AAA	p.R2356K	SRRM2_uc002crj.1_Missense_Mutation_p.R2260K|SRRM2_uc002crl.1_Missense_Mutation_p.R2356K|SRRM2_uc010bsu.1_Missense_Mutation_p.R2260K	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	2356	Ala-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GCCGGCTCCAGAACCGCCGCA	0.627		NaN											0	0	0	0.007413	0	18	155									
BTBD12	84464	broad.mit.edu	37	16	3640791	3640791	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:3640791C>G	uc002cvp.2	-	12	3475	c.2848G>C	c.(2848-2850)GAG>CAG	p.E950Q		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	950	Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						AGCGCCTCCTCTGGCGCCTCC	0.657		NaN						Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				0	0	0	0.013537	0	13	54									
C16orf71	146562	broad.mit.edu	37	16	4797521	4797521	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:4797521G>A	uc002cxn.2	+	9	1920	c.1458G>A	c.(1456-1458)CAG>CAA	p.Q486Q		NM_139170	NP_631909	Q8IYS4	CP071_HUMAN	hypothetical protein LOC146562	486										central_nervous_system(1)	1						CCAAGGGGCAGAGCGCCCAGG	0.667		NaN											0	0	0	0.00308	0	7	20									
NOMO1	23420	broad.mit.edu	37	16	14989478	14989478	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:14989478G>C	uc002dcv.2	+	31	3711	c.3645G>C	c.(3643-3645)AAG>AAC	p.K1215N		NM_014287	NP_055102	Q15155	NOMO1_HUMAN	nodal modulator 1 precursor	1215	Cytoplasmic (Potential).					integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			ovary(1)	1						GACAAGCCAAGAAACAGAAGA	0.607		NaN											0	0	0	0.01441	0	87	515									
ABCC1	4363	broad.mit.edu	37	16	16180768	16180768	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:16180768C>T	uc010bvi.2	+	18	2555	c.2380C>T	c.(2380-2382)CCC>TCC	p.P794S	ABCC1_uc010bvj.2_Missense_Mutation_p.P735S|ABCC1_uc010bvk.2_Intron|ABCC1_uc010bvl.2_Missense_Mutation_p.P794S|ABCC1_uc010bvm.2_Intron|ABCC1_uc002del.3_Missense_Mutation_p.P678S	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	794	ABC transporter 1.|Cytoplasmic.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CTTCGATGATCCCCTCTCAGC	0.592		NaN											0	0	0	0.004482	0	8	75									
DNAH3	55567	broad.mit.edu	37	16	21078642	21078642	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:21078642C>T	uc010vbe.1	-	24	3480	c.3480G>A	c.(3478-3480)CTG>CTA	p.L1160L		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1160	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		AGTAATCATTCAGCCCTTTCT	0.443		NaN											0	0	0	0.00245	0	15	60									
PRKCB	5579	broad.mit.edu	37	16	24231400	24231400	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:24231400C>G	uc002dmd.2	+	17	2179	c.1982C>G	c.(1981-1983)TCT>TGT	p.S661C	PRKCB_uc002dme.2_3'UTR	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	661	AGC-kinase C-terminal.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	GCTGGCTTCTCTTATACTAAC	0.433		NaN											0	0	0	0.00278	0	22	54									
GDPD3	79153	broad.mit.edu	37	16	30123483	30123483	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:30123483C>A	uc002dwp.2	-	6	622	c.543G>T	c.(541-543)AAG>AAT	p.K181N	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|GDPD3_uc002dwq.2_Missense_Mutation_p.K119N|LOC100271831_uc010vei.1_5'Flank	NM_024307	NP_077283	Q7L5L3	GDPD3_HUMAN	glycerophosphodiester phosphodiesterase domain	181	Extracellular (Potential).|GDPD.				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding				0						TGACCGAGCTCTTCTCCGAGG	0.617		NaN									OREG0023731	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	1.04858e-14	0.006214	1.13522e-14	9	71									
GDPD3	79153	broad.mit.edu	37	16	30123690	30123690	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:30123690C>A	uc002dwp.2	-	5	499	c.420G>T	c.(418-420)CAG>CAT	p.Q140H	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|GDPD3_uc002dwq.2_Missense_Mutation_p.Q78H|LOC100271831_uc010vei.1_5'Flank	NM_024307	NP_077283	Q7L5L3	GDPD3_HUMAN	glycerophosphodiester phosphodiesterase domain	140	Extracellular (Potential).|GDPD.				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding				0						TTGGAAACCTCTGGAACAGGT	0.622		NaN									OREG0023731	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	1.58986e-06	0.008291	1.64628e-06	10	88									
GDPD3	79153	broad.mit.edu	37	16	30123730	30123730	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:30123730C>A	uc002dwp.2	-	5	459	c.380G>T	c.(379-381)GGG>GTG	p.G127V	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|GDPD3_uc002dwq.2_Missense_Mutation_p.G65V|LOC100271831_uc010vei.1_5'Flank	NM_024307	NP_077283	Q7L5L3	GDPD3_HUMAN	glycerophosphodiester phosphodiesterase domain	127	Extracellular (Potential).|GDPD.				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding				0						CCGGTCTGACCCGTGAGCAAA	0.602		NaN									OREG0023731	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	1.33987e-11	0.008291	1.43846e-11	9	93									
MAPK3	5595	broad.mit.edu	37	16	30128229	30128229	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:30128229C>T	uc002dws.2	-	7	1103	c.1003G>A	c.(1003-1005)GAC>AAC	p.D335N	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MAPK3_uc002dwr.2_Missense_Mutation_p.D221N|MAPK3_uc002dwv.3_Missense_Mutation_p.D291N|MAPK3_uc002dwt.2_Missense_Mutation_p.D335N|MAPK3_uc002dwu.2_RNA|MAPK3_uc010bzp.2_Intron	NM_002746	NP_002737	P27361	MK03_HUMAN	mitogen-activated protein kinase 3 isoform 1	335					activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|cellular response to mechanical stimulus|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|interleukin-1-mediated signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription initiation from RNA polymerase I promoter	cytosol|nucleoplasm	ATP binding|MAP kinase activity|phosphatase binding				0					Arsenic trioxide(DB01169)|Isoproterenol(DB01064)|Simvastatin(DB00641)|Sulindac(DB00605)	TCCGTCGGGTCATAGTACTGC	0.627		NaN											0	0	0	0.004007	0	16	135									
CES3	23491	broad.mit.edu	37	16	66998585	66998585	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:66998585C>T	uc002eqt.2	+	6	847	c.774C>T	c.(772-774)ATC>ATT	p.I258I	CES3_uc010cdz.2_Silent_p.I258I|CES3_uc010cea.2_RNA|CES3_uc010viw.1_5'Flank	NM_024922	NP_079198	Q6UWW8	EST3_HUMAN	carboxylesterase 3 precursor	258						endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			ovary(3)|central_nervous_system(2)	5		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0488)|Epithelial(162;0.127)		GTGGGGTCATCACCACCCCAG	0.587		NaN											0	0	0	0.012213	0	32	23									
LRRC36	55282	broad.mit.edu	37	16	67404900	67404900	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:67404900G>C	uc002esv.2	+	9	1268	c.1249G>C	c.(1249-1251)GAG>CAG	p.E417Q	LRRC36_uc002esw.2_RNA|LRRC36_uc010ceh.2_Missense_Mutation_p.E149Q|LRRC36_uc002esx.2_Missense_Mutation_p.E296Q|LRRC36_uc010vjk.1_Missense_Mutation_p.E296Q|LRRC36_uc010vjl.1_5'UTR|LRRC36_uc002esy.2_Intron	NM_018296	NP_060766	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36 isoform 1	417											0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		TGTCAATGTAGAGCAACAATT	0.433		NaN											0	0	0	0.001984	0	7	96									
WWP2	11060	broad.mit.edu	37	16	69964146	69964146	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:69964146C>T	uc002exu.1	+	14	1519	c.1430C>T	c.(1429-1431)CCG>CTG	p.P477L	WWP2_uc002exv.1_Missense_Mutation_p.P477L|WWP2_uc010vlm.1_Missense_Mutation_p.P361L|WWP2_uc010vln.1_Missense_Mutation_p.P95L|WWP2_uc002exw.1_Missense_Mutation_p.P38L|uc002exx.1_5'Flank|MIR140_hsa-mir-140|MI0000456_5'Flank	NM_007014	NP_008945	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase	477	WW 4.				entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			lung(3)|ovary(1)|breast(1)|skin(1)	6						GATCCTCGCCCGGGGTTTGAG	0.597		NaN									OREG0023910	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003755	0	32	10									
AP1G1	164	broad.mit.edu	37	16	71799484	71799484	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:71799484C>G	uc010cgg.2	-	7	960	c.646G>C	c.(646-648)GTG>CTG	p.V216L	AP1G1_uc002fba.2_Missense_Mutation_p.V219L|AP1G1_uc002fbb.2_Missense_Mutation_p.V239L|AP1G1_uc010vmg.1_RNA	NM_001128	NP_001119	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1	216					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			ovary(2)	2		Ovarian(137;0.125)				AATTGGGGCACAAGCTGCAGA	0.408		NaN											0	0	0	0.001855	0	12	32									
LRRC50	123872	broad.mit.edu	37	16	84199455	84199455	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:84199455G>A	uc002fhl.3	+	7	1111	c.930G>A	c.(928-930)GAG>GAA	p.E310E	LRRC50_uc010vnw.1_Silent_p.E58E	NM_178452	NP_848547	Q8NEP3	DAAF1_HUMAN	leucine rich repeat containing 50	310					axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding				0						AGCAGTGGGAGAGCAGGGAGC	0.522		NaN							Kartagener_syndrome				0	0	0	0.008291	0	9	91									
ZNF276	92822	broad.mit.edu	37	16	89800365	89800365	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:89800365C>T	uc002fos.3	+	9	1490	c.1393C>T	c.(1393-1395)CGG>TGG	p.R465W	ZNF276_uc010ciq.2_Missense_Mutation_p.R251W|ZNF276_uc002fop.2_Missense_Mutation_p.R373W|ZNF276_uc002foq.3_Missense_Mutation_p.R390W|ZNF276_uc010cir.2_RNA|ZNF276_uc002for.3_Missense_Mutation_p.R251W|ZNF276_uc010cis.2_Missense_Mutation_p.R224W|ZNF276_uc002fot.3_RNA|ZNF276_uc010vpm.1_Missense_Mutation_p.R303W|ZNF276_uc010cit.1_Missense_Mutation_p.R224W	NM_001113525	NP_001106997	Q8N554	ZN276_HUMAN	zinc finger protein 276 isoform a	465	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		GGTCCGGGAGCGGCCCTGCCC	0.627		NaN											0	0	0	0.013537	0	13	19									
ZNF276	92822	broad.mit.edu	37	16	89800436	89800436	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:89800436C>T	uc002fos.3	+	9	1561	c.1464C>T	c.(1462-1464)CTC>CTT	p.L488L	ZNF276_uc010ciq.2_Silent_p.L274L|ZNF276_uc002fop.2_Silent_p.L396L|ZNF276_uc002foq.3_Silent_p.L413L|ZNF276_uc010cir.2_RNA|ZNF276_uc002for.3_Silent_p.L274L|ZNF276_uc010cis.2_Silent_p.L247L|ZNF276_uc002fot.3_RNA|ZNF276_uc010vpm.1_Silent_p.L326L|ZNF276_uc010cit.1_Silent_p.L247L	NM_001113525	NP_001106997	Q8N554	ZN276_HUMAN	zinc finger protein 276 isoform a	488	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		ACGTGAAGCTCATCCACACAG	0.637		NaN											0	0	0	0.010729	0	10	19									
DEF8	54849	broad.mit.edu	37	16	90016035	90016035	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr16:90016035G>A	uc002fpn.1	+	2	251	c.162G>A	c.(160-162)ACG>ACA	p.T54T	DEF8_uc002fpl.2_Intron|DEF8_uc002fpm.2_Intron|DEF8_uc002fpo.1_Intron|DEF8_uc002fpp.1_Intron|DEF8_uc010vpq.1_Intron|DEF8_uc010vpr.1_Intron	NM_207514	NP_997397	Q6ZN54	DEFI8_HUMAN	differentially expressed in FDCP 8 isoform 1	54					intracellular signal transduction		zinc ion binding			central_nervous_system(1)	1		all_cancers(9;7.59e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.0019)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0274)		CGGGCAGGACGCGGGAGGCCA	0.677		NaN											0	0	0	0.009096	0	4	19									
GSG2	83903	broad.mit.edu	37	17	3628001	3628001	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:3628001G>C	uc002fwp.2	+	1	805	c.772G>C	c.(772-774)GAG>CAG	p.E258Q	ITGAE_uc002fwo.3_Intron|ITGAE_uc002fwn.3_5'Flank	NM_031965	NP_114171	Q8TF76	HASP_HUMAN	haspin	258					cell cycle|chromatin modification|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity				0						TGAGGATTCTGAGTTTCGGGC	0.542		NaN											0	0	0	0.001855	0	14	70									
MYBBP1A	10514	broad.mit.edu	37	17	4455916	4455916	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:4455916C>T	uc002fyb.3	-	6	629	c.567G>A	c.(565-567)TCG>TCA	p.S189S	MYBBP1A_uc002fxz.3_Silent_p.S189S	NM_014520	NP_055335	Q9BQG0	MBB1A_HUMAN	MYB binding protein 1a isoform 2	189	Interaction with MYB (By similarity).				nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			ovary(1)|skin(1)	2						ATGTGGCCTTCGAGACCTAAG	0.572		NaN											0	0	0	0.008291	0	8	33									
BCL6B	255877	broad.mit.edu	37	17	6927018	6927018	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:6927018G>C	uc002geg.2	+	2	85	c.28G>C	c.(28-30)GCG>CCG	p.A10P	BCL6B_uc010clt.1_Missense_Mutation_p.A10P	NM_181844	NP_862827	Q8N143	BCL6B_HUMAN	B-cell CLL/lymphoma 6, member B (zinc finger	10						nucleus	zinc ion binding			skin(1)	1						CCCGGAGGGAGCGCTGGGCTA	0.662		NaN											0	0	0	0.003163	0	16	23									
ATP1B2	482	broad.mit.edu	37	17	7557505	7557505	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:7557505C>G	uc002gif.1	+	4	1065	c.482C>G	c.(481-483)TCC>TGC	p.S161C		NM_001678	NP_001669	P14415	AT1B2_HUMAN	Na+/K+ -ATPase beta 2 subunit	161	Extracellular (Potential).				ATP biosynthetic process|blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|sodium:potassium-exchanging ATPase activity	p.0?(2)|p.?(1)		central_nervous_system(1)|pancreas(1)	2		all_cancers(10;0.000178)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;2.55e-06)|READ - Rectum adenocarcinoma(115;0.168)		GGCAACTGCTCCGGCATTGGG	0.562		NaN											0	0	0	0.013114	0	45	214									
TP53	7157	broad.mit.edu	37	17	7578406	7578406	+	Missense_Mutation	SNP	C	C	T	rs28934578		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:7578406C>T	uc002gim.2	-	5	718	c.524G>A	c.(523-525)CGC>CAC	p.R175H	TP53_uc002gig.1_Missense_Mutation_p.R175H|TP53_uc002gih.2_Missense_Mutation_p.R175H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43H|TP53_uc010cng.1_Missense_Mutation_p.R43H|TP53_uc002gii.1_Missense_Mutation_p.R43H|TP53_uc010cnh.1_Missense_Mutation_p.R175H|TP53_uc010cni.1_Missense_Mutation_p.R175H|TP53_uc002gij.2_Missense_Mutation_p.R175H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82H|TP53_uc002gio.2_Missense_Mutation_p.R43H|TP53_uc010vug.1_Missense_Mutation_p.R136H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(729)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R43H(5)|p.R82H(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652	R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(HCC1395_BREAST)|R175H(KLE_ENDOMETRIUM)|R175H(NCIH196_LUNG)|R175H(AU565_BREAST)|R175H(TYKNU_OVARY)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(SKUT1_SOFT_TISSUE)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(LS123_LARGE_INTESTINE)|R175H(SKBR3_BREAST)|R175H(RKN_OVARY)|R175H(HUCCT1_BILIARY_TRACT)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.01441	0	48	15									
ARHGEF15	22899	broad.mit.edu	37	17	8222159	8222159	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:8222159C>T	uc002glc.2	+	12	2085	c.1964C>T	c.(1963-1965)TCG>TTG	p.S655L	ARHGEF15_uc002gld.2_Missense_Mutation_p.S655L|ARHGEF15_uc010vuw.1_Missense_Mutation_p.S544L	NM_173728	NP_776089	O94989	ARHGF_HUMAN	Rho guanine exchange factor 15	655					negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						CTCTTTGCCTCGCGCCCCCGC	0.642		NaN											0	0	0	0.003755	0	33	293									
MYH10	4628	broad.mit.edu	37	17	8424198	8424198	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:8424198C>G	uc002gll.2	-	17	2274	c.2178G>C	c.(2176-2178)CAG>CAC	p.Q726H	MYH10_uc002glm.2_Missense_Mutation_p.Q757H|MYH10_uc010cnx.2_Missense_Mutation_p.Q735H	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	726	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						AGCAATACCTCTGTCTGAATT	0.398		NaN											0	0	0	0.000602	0	5	43									
FAM18B2	201158	broad.mit.edu	37	17	15406428	15406428	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:15406428G>A	uc002goq.2	-	6	764	c.581C>T	c.(580-582)TCG>TTG	p.S194L	CDRT4_uc010vvw.1_Missense_Mutation_p.S151L|FAM18B2_uc010vvx.1_Intron	NM_145301	NP_660344	Q96ET8	F18B2_HUMAN	hypothetical protein LOC201158 isoform 1	194						integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0872)|BRCA - Breast invasive adenocarcinoma(8;0.0581)|READ - Rectum adenocarcinoma(1115;0.0967)		AAACTTCCTCGAGGGATggcc	0.264		NaN											0	0	0	0.004672	0	3	20									
TRIM16	10626	broad.mit.edu	37	17	15532172	15532172	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:15532172C>T	uc002gox.2	-	9	2009	c.1452G>A	c.(1450-1452)GAG>GAA	p.E484E	TRIM16_uc002gor.1_Intron|TRIM16_uc002gow.2_Silent_p.E268E|TRIM16_uc002goy.2_Silent_p.E354E	NM_006470	NP_006461	O95361	TRI16_HUMAN	tripartite motif-containing 16	484	B30.2/SPRY.				histone H3 acetylation|histone H4 acetylation|positive regulation of interleukin-1 beta secretion|positive regulation of keratinocyte differentiation|positive regulation of retinoic acid receptor signaling pathway|positive regulation of transcription, DNA-dependent|response to growth hormone stimulus|response to organophosphorus|response to retinoic acid	cytoplasm|plasma membrane|PML body	DNA binding|interleukin-1 binding|NACHT domain binding|zinc ion binding			ovary(2)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0839)|Epithelial(1;8.4e-29)|all cancers(1;3.06e-28)|Colorectal(1;1.57e-19)|OV - Ovarian serous cystadenocarcinoma(1;6.1e-17)|COAD - Colon adenocarcinoma(1;3.38e-12)|READ - Rectum adenocarcinoma(2;1.46e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0559)		TGAGTGGGGTCTCCATGTCAC	0.552		NaN											0	0	0	0.010504	0	21	80									
TOP3A	7156	broad.mit.edu	37	17	18188586	18188586	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:18188586C>T	uc002gsx.1	-	15	1976	c.1747G>A	c.(1747-1749)GAC>AAC	p.D583N	TOP3A_uc010cpz.1_Missense_Mutation_p.D35N|TOP3A_uc010vxr.1_Missense_Mutation_p.D113N|TOP3A_uc002gsw.1_Missense_Mutation_p.D35N|TOP3A_uc010vxs.1_Missense_Mutation_p.D481N	NM_004618	NP_004609	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	583					DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			skin(3)	3						GCCCGGAGGTCAGGCTTAGAC	0.517		NaN											0	0	0	0.004007	0	17	61									
RPL23A	6147	broad.mit.edu	37	17	27047838	27047838	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:27047838C>T	uc002hci.2	+	2	163	c.139C>T	c.(139-141)CGG>TGG	p.R47W	RAB34_uc002hce.2_5'Flank|RAB34_uc002hcg.2_5'Flank|RAB34_uc002hcf.2_5'Flank|RAB34_uc010was.1_5'Flank|RAB34_uc010wat.1_5'Flank|RAB34_uc002hch.2_5'Flank|RAB34_uc010wau.1_5'Flank|RAB34_uc010wav.1_5'Flank|RPL23A_uc002hck.1_RNA|SNORD4A_uc002hcl.2_5'Flank|SNORD42A_uc002hcm.1_5'Flank|SNORD4B_uc002hcn.1_5'Flank	NM_000984	NP_000975	P62750	RL23A_HUMAN	ribosomal protein L23a	47					cell proliferation|endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleus	nucleotide binding|protein binding|rRNA binding|structural constituent of ribosome			ovary(1)	1	Lung NSC(42;0.00431)					ACCCACCTTCCGGCGGCCGAA	0.537		NaN									OREG0024282	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003954	0	19	49									
CPD	1362	broad.mit.edu	37	17	28747979	28747979	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:28747979C>T	uc002hfb.1	+	3	1130	c.1115C>T	c.(1114-1116)TCT>TTT	p.S372F	CPD_uc010wbo.1_Missense_Mutation_p.S125F|CPD_uc010wbp.1_RNA	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	372	Extracellular (Potential).|Carboxypeptidase-like 1.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						AATCGTGAGTCTTTGATCACA	0.398		NaN											0	0	0	0.001168	0	5	61									
CPD	1362	broad.mit.edu	37	17	28749808	28749808	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:28749808C>G	uc002hfb.1	+	5	1439	c.1424C>G	c.(1423-1425)TCA>TGA	p.S475*	CPD_uc010wbo.1_Nonsense_Mutation_p.S228*|CPD_uc010wbp.1_RNA	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	475	Extracellular (Potential).|Carboxypeptidase-like 1.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						GAGGCTGTATCAACTGCTAGC	0.448		NaN											0	0	0	0.001984	0	7	117									
ATAD5	79915	broad.mit.edu	37	17	29184080	29184080	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:29184080G>A	uc002hfs.1	+	8	3089	c.2743G>A	c.(2743-2745)GAA>AAA	p.E915K	ATAD5_uc002hft.1_Missense_Mutation_p.E812K	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	915					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				TGCTCTTGGTGAATTTTCAAC	0.353		NaN											0	0	0	0.006122	0	19	43									
ATAD5	79915	broad.mit.edu	37	17	29221167	29221167	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:29221167G>C	uc002hfs.1	+	21	5642	c.5296G>C	c.(5296-5298)GAC>CAC	p.D1766H		NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1766					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				AGCTAATTTAGAGTAAGTCTT	0.294		NaN											0	0	0	0.009096	0	4	31									
RHOT1	55288	broad.mit.edu	37	17	30525994	30525994	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:30525994G>A	uc002hgz.2	+	12	1137	c.898G>A	c.(898-900)GAA>AAA	p.E300K	RHOT1_uc002hgw.2_Missense_Mutation_p.E300K|RHOT1_uc002hgy.2_Missense_Mutation_p.E300K|RHOT1_uc002hha.2_Missense_Mutation_p.E173K|RHOT1_uc010csv.2_RNA|RHOT1_uc002hgx.2_Missense_Mutation_p.E173K|RHOT1_uc010wby.1_Missense_Mutation_p.E300K|RHOT1_uc002hhb.2_Missense_Mutation_p.E279K|RHOT1_uc002hgv.2_Missense_Mutation_p.E300K	NM_018307	NP_060777	Q8IXI2	MIRO1_HUMAN	ras homolog gene family, member T1 isoform 3	300	Mitochondrial intermembrane (Potential).				apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			ovary(3)|central_nervous_system(1)	4		Myeloproliferative disorder(56;0.0255)|Breast(31;0.116)|Ovarian(249;0.182)				TTGCACTACTGAATTAAATCA	0.239		NaN											0	0	0	0.005443	0	26	82									
RDM1	201299	broad.mit.edu	37	17	34251717	34251717	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:34251717C>T	uc002hkh.2	-	4	508	c.459G>A	c.(457-459)CCG>CCA	p.P153P	RDM1_uc010cty.2_Intron|RDM1_uc010ctz.2_Intron|RDM1_uc010cua.2_Silent_p.P130P|RDM1_uc002hkg.3_Silent_p.P130P|RDM1_uc010cub.2_Intron|RDM1_uc010cud.2_Silent_p.P153P|RDM1_uc010cuf.2_Intron|RDM1_uc010cue.2_Intron|RDM1_uc010cug.2_Intron|RDM1_uc010cuc.2_Intron|RDM1_uc010wco.1_Intron|RDM1_uc010wcp.1_Silent_p.P130P|RDM1_uc002hki.2_Silent_p.P153P	NM_145654	NP_663629	Q8NG50	RDM1_HUMAN	RAD52 motif 1 isoform 1	153					DNA recombination|DNA repair	Cajal body|cytoplasm|nucleolus|PML body	DNA binding|nucleotide binding|RNA binding			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		GGCTTTGCTTCGGAAGTGGCA	0.468		NaN						Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.008361	0	32	82									
MRM1	79922	broad.mit.edu	37	17	34964210	34964210	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:34964210C>T	uc002hne.2	+	3	956	c.741C>T	c.(739-741)CTC>CTT	p.L247L	MRM1_uc002hnf.2_Silent_p.L52L	NM_024864	NP_079140	Q6IN84	MRM1_HUMAN	mitochondrial rRNA methyltransferase 1 homolog	247					RNA processing	mitochondrion	RNA binding|RNA methyltransferase activity				0		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		TGGAGTTCCTCTGGGAACGGC	0.612		NaN											0	0	0	0.003163	0	15	87									
ACACA	31	broad.mit.edu	37	17	35614676	35614676	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:35614676G>C	uc002hnm.2	-	14	1855	c.1664C>G	c.(1663-1665)TCT>TGT	p.S555C	ACACA_uc002hnk.2_Missense_Mutation_p.S477C|ACACA_uc002hnl.2_Missense_Mutation_p.S497C|ACACA_uc002hnn.2_Missense_Mutation_p.S555C|ACACA_uc002hno.2_Missense_Mutation_p.S592C|ACACA_uc010cuz.2_Missense_Mutation_p.S555C	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	555	Biotin carboxylation.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	ACCAAACTGAGAATCAGCAAA	0.393		NaN											0	0	0	0.008291	0	11	63									
ZPBP2	124626	broad.mit.edu	37	17	38027018	38027018	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:38027018G>T	uc002hte.2	+	3	343	c.190G>T	c.(190-192)GAA>TAA	p.E64*	ZPBP2_uc002htf.2_Nonsense_Mutation_p.E42*	NM_199321	NP_955353	Q6X784	ZPBP2_HUMAN	zona pellucida binding protein 2 isoform 2	64					binding of sperm to zona pellucida	extracellular region				ovary(1)	1	Colorectal(19;0.000442)		Lung(15;0.00849)|LUSC - Lung squamous cell carcinoma(15;0.171)			TTCTAAAAAAGAAATAGTGGA	0.284		NaN											1	0	3.59834e-05	0.001168	3.69621e-05	5	58									
ZPBP2	124626	broad.mit.edu	37	17	38027764	38027764	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:38027764G>C	uc002hte.2	+	4	445	c.292G>C	c.(292-294)GAT>CAT	p.D98H	ZPBP2_uc002htf.2_Missense_Mutation_p.D76H	NM_199321	NP_955353	Q6X784	ZPBP2_HUMAN	zona pellucida binding protein 2 isoform 2	98					binding of sperm to zona pellucida	extracellular region				ovary(1)	1	Colorectal(19;0.000442)		Lung(15;0.00849)|LUSC - Lung squamous cell carcinoma(15;0.171)			GATGGTGAAAGATTTTTTGGA	0.284		NaN											0	0	0	0.006122	0	17	131									
ACLY	47	broad.mit.edu	37	17	40028327	40028327	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:40028327C>T	uc002hyg.2	-	24	2914	c.2751G>A	c.(2749-2751)GGG>GGA	p.G917G	ACLY_uc002hyh.2_Silent_p.G907G|ACLY_uc002hyi.2_Silent_p.G971G|ACLY_uc010wfx.1_Silent_p.G961G|ACLY_uc010wfy.1_Silent_p.G646G	NM_001096	NP_001087	P53396	ACLY_HUMAN	ATP citrate lyase isoform 1	917				AGKD -> TAVE (in Ref. 1; CAA45614).	ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			ovary(2)|central_nervous_system(1)	3		Breast(137;0.000143)				CCAGGTCTTTCCCAGCTCGCG	0.567		NaN											0	0	0	0.009096	0	4	37									
ACLY	47	broad.mit.edu	37	17	40039486	40039486	+	Splice_Site	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:40039486C>A	uc002hyg.2	-	20	2318	c.2155_splice	c.e20-1	p.I719_splice	ACLY_uc002hyh.2_Splice_Site_p.I709_splice|ACLY_uc002hyi.2_Splice_Site_p.I773_splice|ACLY_uc010wfx.1_Splice_Site_p.I763_splice|ACLY_uc010wfy.1_Splice_Site_p.I448_splice	NM_001096	NP_001087	P53396	ACLY_HUMAN	ATP citrate lyase isoform 1						ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			ovary(2)|central_nervous_system(1)	3		Breast(137;0.000143)				TGCCCCCAATCTGCCAAGGAA	0.517		NaN											1	0	1.33986e-20	0.004656	1.4679e-20	26	37									
PLEKHM1	9842	broad.mit.edu	37	17	43515225	43515225	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:43515225C>T	uc002ija.2	-	12	3340	c.3170G>A	c.(3169-3171)TGA>TAA	p.*1057*	PLEKHM1_uc010wjm.1_Silent_p.*1029*|PLEKHM1_uc002ijb.2_Silent_p.*532*	NM_014798	NP_055613	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M	1057					intracellular signal transduction	cytoplasm	metal ion binding				0	Renal(3;0.0405)					AGATGGGCATCAGGCGAAAAT	0.627		NaN											0	0	0	0.000602	0	5	42									
OSBPL7	114881	broad.mit.edu	37	17	45897373	45897373	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:45897373G>A	uc002ilx.1	-	3	368	c.165C>T	c.(163-165)CTC>CTT	p.L55L		NM_145798	NP_665741	Q9BZF2	OSBL7_HUMAN	oxysterol-binding protein-like protein 7	55	PH.				lipid transport		lipid binding				0						TCCTCTTCTTGAGCAGGTGAC	0.652		NaN											0	0	0	0.004672	0	3	24									
OSBPL7	114881	broad.mit.edu	37	17	45897592	45897592	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:45897592G>C	uc002ilx.1	-	2	256	c.53C>G	c.(52-54)TCA>TGA	p.S18*		NM_145798	NP_665741	Q9BZF2	OSBL7_HUMAN	oxysterol-binding protein-like protein 7	18					lipid transport		lipid binding				0						GCTGGGCTTTGAGGACTGAGC	0.637		NaN											0	0	0	0.009096	0	4	24									
ABCC3	8714	broad.mit.edu	37	17	48735563	48735563	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:48735563G>A	uc002isl.2	+	5	687	c.607G>A	c.(607-609)GAC>AAC	p.D203N	ABCC3_uc002isk.3_Missense_Mutation_p.D203N	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	203	Cytoplasmic (By similarity).				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	AAAGAATGTCGACCCTGTGAG	0.567		NaN											0	0	0	0.00499	0	15	74									
TRIM25	7706	broad.mit.edu	37	17	54991173	54991173	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:54991173C>T	uc002iut.2	-	1	237	c.177G>A	c.(175-177)GCG>GCA	p.A59A	TRIM25_uc010dcj.2_5'UTR	NM_005082	NP_005073	Q14258	TRI25_HUMAN	tripartite motif-containing 25	59					innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|response to virus	cell junction|cytosol|nucleus	sequence-specific DNA binding transcription factor activity|ubiquitin-protein ligase activity|zinc ion binding			lung(1)|breast(1)|skin(1)	3	Breast(9;6.15e-08)					GCTGCGGTCGCGCCTGGTAGA	0.692		NaN											0	0	0	0.004672	0	3	7									
BZRAP1	9256	broad.mit.edu	37	17	56405156	56405156	+	Silent	SNP	G	G	A	rs148586326		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:56405156G>A	uc002ivx.3	-	1	997	c.126C>T	c.(124-126)ATC>ATT	p.I42I	BZRAP1_uc010dcs.2_Silent_p.I42I|BZRAP1_uc010wnt.1_Silent_p.I42I|uc010dct.1_5'Flank|uc010dcu.1_5'Flank	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	42						mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GAGTATCAGCGATGCTTGGGG	0.637		NaN											0	0	0	0.009096	0	4	31									
INTS2	57508	broad.mit.edu	37	17	59949655	59949655	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:59949655C>T	uc002izn.2	-	20	2849	c.2773G>A	c.(2773-2775)GAA>AAA	p.E925K	INTS2_uc002izm.2_Missense_Mutation_p.E917K	NM_020748	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	925					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3						TTTTTCAATTCTTCCCTGGTA	0.388		NaN											0	0	0	0.00245	0	14	28									
SCN4A	6329	broad.mit.edu	37	17	62018968	62018968	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:62018968C>T	uc002jds.1	-	24	4751	c.4674G>A	c.(4672-4674)GAG>GAA	p.E1558E		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1558	IV.				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	TGCCCGGGTTCTCCAGGTTGG	0.602		NaN											0	0	0	0.001855	0	13	28									
CACNG1	786	broad.mit.edu	37	17	65052309	65052309	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:65052309C>T	uc002jfu.2	+	4	662	c.591C>T	c.(589-591)CTC>CTT	p.L197L		NM_000727	NP_000718	Q06432	CCG1_HUMAN	voltage-dependent calcium channel gamma-1	197	Helical; (Potential).				muscle contraction	voltage-gated calcium channel complex	voltage-gated calcium channel activity				0	all_cancers(12;1.04e-10)|Breast(2;1.45e-16)|all_epithelial(3;4.81e-12)				Amlodipine(DB00381)|Diltiazem(DB00343)|Ibutilide(DB00308)|Lercanidipine(DB00528)|Magnesium Sulfate(DB00653)|Nimodipine(DB00393)|Nitrendipine(DB01054)|Verapamil(DB00661)	TCGGCGGTCTCGCCCTCCTGC	0.612		NaN											0	0	0	0.010729	0	11	63									
MAP2K6	5608	broad.mit.edu	37	17	67519677	67519677	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:67519677C>T	uc002jij.2	+	8	846	c.558C>T	c.(556-558)CTC>CTT	p.L186L		NM_002758	NP_002749	P52564	MP2K6_HUMAN	mitogen-activated protein kinase kinase 6	186	Protein kinase.				activation of MAPK activity|cell cycle arrest|DNA damage induced protein phosphorylation|innate immune response|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of muscle cell differentiation|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|pancreas(1)	5	Breast(10;6.05e-10)					CTAATGTACTCATCAATGCTC	0.448		NaN											0	0	0	0.01441	0	75	136									
DNAI2	64446	broad.mit.edu	37	17	72297244	72297244	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:72297244C>T	uc002jkf.2	+	8	1023	c.924C>T	c.(922-924)ATC>ATT	p.I308I	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	308					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						TCTTGGACATCACCAAGAAGG	0.547		NaN							Kartagener_syndrome				0	0	0	0.01441	0	61	78									
TMEM104	54868	broad.mit.edu	37	17	72832682	72832682	+	Silent	SNP	C	C	T	rs147463051	byFrequency	TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:72832682C>T	uc002jls.3	+	10	1509	c.1347C>T	c.(1345-1347)ACC>ACT	p.T449T	TMEM104_uc010wrf.1_Intron|TMEM104_uc010wrg.1_Intron|TMEM104_uc010dfx.2_Silent_p.T449T	NM_017728	NP_060198	Q8NE00	TM104_HUMAN	transmembrane protein 104	449	Cytoplasmic (Potential).					integral to membrane					0	all_lung(278;0.23)					GCAGGGACACCCAGCTGGCCT	0.642		NaN											0	0	0	0.009096	0	4	48									
ACOX1	51	broad.mit.edu	37	17	73945836	73945836	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr17:73945836C>T	uc002jqf.2	-	10	1731	c.1441G>A	c.(1441-1443)GAA>AAA	p.E481K	ACOX1_uc010wsq.1_Missense_Mutation_p.E443K|ACOX1_uc002jqe.2_Missense_Mutation_p.E481K|ACOX1_uc010wsr.1_Missense_Mutation_p.E413K	NM_007292	NP_009223	Q15067	ACOX1_HUMAN	acyl-Coenzyme A oxidase 1 isoform b	481					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|prostaglandin metabolic process|very long-chain fatty acid metabolic process	peroxisomal matrix	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity|flavin adenine dinucleotide binding|protein N-terminus binding			ovary(1)	1						GTTAGGCTTTCGGGGCTGTTG	0.572		NaN											0	0	0	0.00308	0	7	55									
GATA6	2627	broad.mit.edu	37	18	19762943	19762943	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr18:19762943C>G	uc002ktt.1	+	6	1824	c.1559C>G	c.(1558-1560)TCT>TGT	p.S520C	GATA6_uc002ktu.1_Missense_Mutation_p.S520C	NM_005257	NP_005248	Q92908	GATA6_HUMAN	GATA binding protein 6	520					blood coagulation|cardiac vascular smooth muscle cell differentiation|cellular response to hypoxia|intestinal epithelial cell differentiation|male gonad development|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor-beta1 production|negative regulation of transforming growth factor-beta2 production|outflow tract septum morphogenesis|positive regulation of angiogenesis|positive regulation of cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter|response to drug|response to growth factor stimulus		protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(3)	3	all_cancers(21;0.00271)|all_epithelial(16;7.31e-05)|Ovarian(2;0.116)|Lung NSC(20;0.123)|all_lung(20;0.246)		STAD - Stomach adenocarcinoma(5;0.106)			ACTTCCACCTCTTCTAACTCA	0.393		NaN											0	0	0	0.01441	0	76	51									
NPC1	4864	broad.mit.edu	37	18	21121061	21121061	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr18:21121061G>C	uc002kum.3	-	16	2759	c.2485C>G	c.(2485-2487)CTG>GTG	p.L829V	NPC1_uc010xaz.1_Missense_Mutation_p.L562V|NPC1_uc010xba.1_Missense_Mutation_p.L674V	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	829					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					TCCTTTAGCAGAAGTGGAGAA	0.443		NaN											0	0	0	0.007413	0	18	186									
NPC1	4864	broad.mit.edu	37	18	21123451	21123451	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr18:21123451G>A	uc002kum.3	-	14	2487	c.2213C>T	c.(2212-2214)TCA>TTA	p.S738L	NPC1_uc010xaz.1_Missense_Mutation_p.S471L|NPC1_uc010xba.1_Missense_Mutation_p.S583L	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	738	SSD.				autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					AGAAAAGGATGACAGGAACAT	0.453		NaN											0	0	0	0.001855	0	11	151									
ASXL3	80816	broad.mit.edu	37	18	31323636	31323636	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr18:31323636C>T	uc010dmg.1	+	12	3879	c.3824C>T	c.(3823-3825)TCT>TTT	p.S1275F	ASXL3_uc002kxq.2_Missense_Mutation_p.S982F	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1275	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						ACTACAATTTCTGCTTGTAAT	0.393		NaN											0	0	0	0.001168	0	5	77									
MYO5B	4645	broad.mit.edu	37	18	47500910	47500910	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr18:47500910G>A	uc002leb.2	-	10	1420	c.1132C>T	c.(1132-1134)CAT>TAT	p.H378Y	MYO5B_uc002lec.1_Missense_Mutation_p.H377Y	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	378	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		AGCTTGCGATGACACAGCCAG	0.577		NaN											0	0	0	0.01441	0	49	37									
C18orf54	162681	broad.mit.edu	37	18	51898905	51898905	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr18:51898905C>T	uc002lfn.3	+	6	1029	c.913C>T	c.(913-915)CAA>TAA	p.Q305*	C18orf54_uc002lfo.3_Nonsense_Mutation_p.Q466*	NM_173529	NP_775800	Q8IYD9	CR054_HUMAN	hypothetical protein LOC162681 precursor	305						extracellular region				ovary(1)|skin(1)	2				Colorectal(16;0.0206)|READ - Rectum adenocarcinoma(59;0.186)		ATTTAACCTTCAAGCAGTACA	0.338		NaN											0	0	0	0.00333	0	25	64									
CCDC102B	79839	broad.mit.edu	37	18	66564576	66564576	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr18:66564576G>A	uc002lkk.2	+	8	1397	c.1174G>A	c.(1174-1176)GAG>AAG	p.E392K	CCDC102B_uc002lki.2_Missense_Mutation_p.E392K|CCDC102B_uc002lkj.1_Missense_Mutation_p.E392K	NM_001093729	NP_001087198	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	392	Potential.									ovary(1)|lung(1)|skin(1)	3		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				AGAAATGGAAGAGCTTTTGGA	0.393		NaN											0	0	0	0.010729	0	12	83									
CNDP2	55748	broad.mit.edu	37	18	72186206	72186206	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr18:72186206G>C	uc002llm.1	+	11	1395	c.1233G>C	c.(1231-1233)TTG>TTC	p.L411F	CNDP2_uc002lln.1_Missense_Mutation_p.L327F|CNDP2_uc010dqs.2_Intron	NM_018235	NP_060705	Q96KP4	CNDP2_HUMAN	CNDP dipeptidase 2	411						cytoplasm	carboxypeptidase activity|metal ion binding|metallopeptidase activity|protein binding|tripeptidase activity			ovary(2)|skin(1)	3		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.22)		AGCCAGACTTGACCAGGGAAG	0.557		NaN											0	0	0	0.005524	0	36	32									
CSNK1G2	1455	broad.mit.edu	37	19	1969891	1969891	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:1969891G>A	uc002lul.3	+	3	643	c.120G>A	c.(118-120)CTG>CTA	p.L40L	CSNK1G2_uc010dsu.2_5'UTR	NM_001319	NP_001310	P78368	KC1G2_HUMAN	casein kinase 1, gamma 2	40					sphingolipid metabolic process|Wnt receptor signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity			stomach(1)	1		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGGGGTCCTGATGGTGGGCC	0.706		NaN											0	0	0	0.008291	0	8	4									
NCLN	56926	broad.mit.edu	37	19	3186161	3186161	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:3186161G>C	uc002lxi.2	+	1	287	c.133G>C	c.(133-135)GAG>CAG	p.E45Q	NCLN_uc002lxh.1_RNA	NM_020170	NP_064555	Q969V3	NCLN_HUMAN	nicalin precursor	45	Lumenal (Potential).				proteolysis|regulation of signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	peptidase activity|protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.83e-113)|Epithelial(107;1.65e-111)|all cancers(105;1.53e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00139)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCCGCGCACGAGTTCACCGT	0.721		NaN											0	0	0	0.00308	0	7	8									
ZNF799	90576	broad.mit.edu	37	19	12502718	12502718	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:12502718C>G	uc010dyt.2	-	4	644	c.494G>C	c.(493-495)GGA>GCA	p.G165A	ZNF799_uc002mts.3_Intron	NM_001080821	NP_001074290	Q96GE5	ZN799_HUMAN	zinc finger protein 799	165					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6						TGGTTTCTTTCCAGTGTGAAG	0.428		NaN											0	0	0	0.001168	0	6	100									
GIPC1	10755	broad.mit.edu	37	19	14591576	14591576	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:14591576G>A	uc002myt.2	-	5	573	c.303C>T	c.(301-303)ACC>ACT	p.T101T	GIPC1_uc002myu.2_Silent_p.T101T|GIPC1_uc002myv.2_Silent_p.T4T|GIPC1_uc002myw.2_Silent_p.T4T|GIPC1_uc002myx.2_Silent_p.T101T|GIPC1_uc002myy.2_Silent_p.T4T	NM_005716	NP_005707	O14908	GIPC1_HUMAN	regulator of G-protein signalling 19 interacting	101					endothelial cell migration|G-protein coupled receptor protein signaling pathway|glutamate secretion|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|protein targeting|regulation of protein stability|regulation of synaptic plasticity|synaptic transmission	cell cortex|dendritic shaft|dendritic spine|membrane fraction|soluble fraction|synaptic vesicle|vesicle membrane	actin binding|myosin binding|protein homodimerization activity|receptor binding				0						GGGTGTTCAGGGTGCAGAACA	0.612		NaN									OREG0025316	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001168	0	6	39									
ARMC6	93436	broad.mit.edu	37	19	19168416	19168416	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:19168416G>C	uc002nld.2	+	9	1833	c.1485G>C	c.(1483-1485)CAG>CAC	p.Q495H	ARMC6_uc002nlc.2_Missense_Mutation_p.Q470H|ARMC6_uc010xql.1_Missense_Mutation_p.Q402H|ARMC6_uc002nle.2_Missense_Mutation_p.Q470H|ARMC6_uc010xqm.1_Missense_Mutation_p.Q495H	NM_033415	NP_219483	Q6NXE6	ARMC6_HUMAN	armadillo repeat containing 6	495							protein binding				0			OV - Ovarian serous cystadenocarcinoma(5;5.66e-06)|Epithelial(12;0.000391)			GGACAGGCCAGAGGGGCAACC	0.652		NaN											0	0	0	0.001168	0	5	29									
GMIP	51291	broad.mit.edu	37	19	19745863	19745863	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:19745863C>T	uc002nnd.2	-	16	1837	c.1720G>A	c.(1720-1722)GAG>AAG	p.E574K	GMIP_uc010xrb.1_Missense_Mutation_p.E548K|GMIP_uc010xrc.1_Missense_Mutation_p.E545K	NM_016573	NP_057657	Q9P107	GMIP_HUMAN	GEM interacting protein	574	Rho-GAP.				negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			ovary(1)	1						TGTTCTATCTCAGCCGTGCAC	0.597		NaN											0	0	0	0.00499	0	17	92									
ZNF208	7757	broad.mit.edu	37	19	22156691	22156691	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:22156691G>C	uc002nqp.2	-	4	1294	c.1145C>G	c.(1144-1146)TCA>TGA	p.S382*	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACTAAGGGTTGAGGGCCACTT	0.368		NaN											0	0	0	0.003163	0	12	60									
SLC7A9	11136	broad.mit.edu	37	19	33334854	33334854	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:33334854G>A	uc002ntv.3	-	10	1098	c.981C>T	c.(979-981)CTC>CTT	p.L327L	SLC7A9_uc002ntt.3_Intron|SLC7A9_uc002ntu.3_Silent_p.L327L|SLC7A9_uc002ntw.3_Silent_p.L118L	NM_001126335	NP_001119807	P82251	BAT1_HUMAN	solute carrier family 7, member 9	327	Cytoplasmic (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding			skin(1)	1	Esophageal squamous(110;0.137)				L-Cystine(DB00138)	CCACGTAAATGAGTCTGGAAA	0.577		NaN											0	0	0	0.000602	0	5	37									
ZNF585B	92285	broad.mit.edu	37	19	37676275	37676275	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:37676275C>T	uc002ofq.2	-	5	2418	c.2164G>A	c.(2164-2166)GAG>AAG	p.E722K	uc002ofp.1_5'Flank|ZNF585B_uc002ofr.1_Missense_Mutation_p.E536K	NM_152279	NP_689492	Q52M93	Z585B_HUMAN	zinc finger protein 585B	722	C2H2-type 20.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTCCCACACTCAGCACACACG	0.463		NaN											0	0	0	0.007413	0	18	121									
HIPK4	147746	broad.mit.edu	37	19	40886303	40886303	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:40886303G>A	uc002onp.2	-	3	1880	c.1595C>T	c.(1594-1596)TCT>TTT	p.S532F		NM_144685	NP_653286	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	532						cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			TGGCTCAGCAGAGGCCCCGAG	0.607		NaN											0	0	0	0.001984	0	7	68									
LIPE	3991	broad.mit.edu	37	19	42906092	42906092	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:42906092C>G	uc002otr.2	-	10	3380	c.3103G>C	c.(3103-3105)GAG>CAG	p.E1035Q	uc010eif.1_Intron	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	1035					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				TGGCGCGTCTCGCGGCACAGC	0.756		NaN											0	0	0	0.004672	0	2	3									
PSG1	5669	broad.mit.edu	37	19	43382132	43382132	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:43382132G>A	uc002ovb.2	-	2	501	c.363C>T	c.(361-363)ACC>ACT	p.T121T	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Silent_p.T121T|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_RNA|PSG1_uc002our.1_Silent_p.T121T|PSG1_uc010eio.1_Silent_p.T121T|PSG1_uc002oux.1_Silent_p.T50T|PSG1_uc002ouy.1_Silent_p.T121T|PSG1_uc002ouz.1_Silent_p.T121T|PSG1_uc002ova.1_Silent_p.T121T|PSG1_uc002ovc.2_Silent_p.T121T|PSG1_uc002ovd.1_Silent_p.T121T	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	121	Ig-like V-type.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				TGATGTGTAAGGTGTAGGATC	0.478		NaN											0	0	0	0.01441	0	31	280									
PSG7	5676	broad.mit.edu	37	19	43430668	43430668	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:43430668C>T	uc002ovl.3	-	5	1012	c.910G>A	c.(910-912)GAA>AAA	p.E304K	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_RNA|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Missense_Mutation_p.E182K	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	304	Ig-like C2-type 2.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				GGTCCTGTTTCATTTCTCGTG	0.498		NaN											0	0	0	0.01441	0	49	276									
PSG7	5676	broad.mit.edu	37	19	43439684	43439684	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:43439684A>G	uc002ovl.3	-	3	404	c.302T>C	c.(301-303)GTA>GCA	p.V101A	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Intron	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	101	Ig-like V-type.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				ATTGGAATATACTGTTTCTCA	0.418		NaN											0	0	0	0.003755	0	30	585									
ZNF230	7773	broad.mit.edu	37	19	44514752	44514752	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:44514752G>C	uc002oyb.1	+	5	812	c.561G>C	c.(559-561)CAG>CAC	p.Q187H		NM_006300	NP_006291	Q9UIE0	ZN230_HUMAN	zinc finger protein 230	187	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				GTATTCACCAGAGAGTTCACT	0.458		NaN											0	0	0	0.01441	0	53	125									
ZC3H4	23211	broad.mit.edu	37	19	47569810	47569810	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:47569810C>T	uc002pga.3	-	15	3753	c.3715G>A	c.(3715-3717)GAG>AAG	p.E1239K	ZC3H4_uc002pgb.1_RNA	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	1239							nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		GGGGCACCCTCGGGGGGTGGG	0.701		NaN											0	0	0	0.009096	0	4	7									
RRAS	6237	broad.mit.edu	37	19	50138855	50138855	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:50138855C>T	uc002pop.1	-	6	680	c.635G>A	c.(634-636)GGC>GAC	p.G212D		NM_006270	NP_006261	P10301	RRAS_HUMAN	related RAS viral (r-ras) oncogene homolog	212					axon guidance|Ras protein signal transduction|synaptic transmission	intracellular|plasma membrane	GDP binding|GTP binding|GTPase activity|protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.00114)|GBM - Glioblastoma multiforme(134;0.0206)		GCAGGGGCAGCCCCCGCCCTT	0.547		NaN											0	0	0	0.01441	0	50	72									
NAPSA	9476	broad.mit.edu	37	19	50864260	50864260	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:50864260C>T	uc002prx.2	-	5	659	c.606G>A	c.(604-606)CCG>CCA	p.P202P	NR1H2_uc002prv.3_Intron	NM_004851	NP_004842	O96009	NAPSA_HUMAN	napsin A preproprotein	202					proteolysis	extracellular region	aspartic-type endopeptidase activity				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00743)|GBM - Glioblastoma multiforme(134;0.0183)		GTACATCCATCGGGGGCCGAA	0.532		NaN											0	0	0	0.00623	0	38	77									
SHANK1	50944	broad.mit.edu	37	19	51219704	51219704	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:51219704A>G	uc002psx.1	-	2	306	c.287T>C	c.(286-288)ATC>ACC	p.I96T		NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	96					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GGCCGTCCAGATGGTGGCATC	0.637		NaN											0	0	0	0.010504	0	20	45									
LIM2	3982	broad.mit.edu	37	19	51890572	51890572	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:51890572C>T	uc002pwm.2	-	2	170	c.126G>A	c.(124-126)CTG>CTA	p.L42L	LIM2_uc002pwl.2_Silent_p.L42L	NM_001161748	NP_001155220	P55344	LMIP_HUMAN	lens intrinsic membrane protein 2, 19kDa isoform	42	Extracellular (Potential).				cell-cell junction assembly	cell junction|integral to membrane	structural constituent of eye lens				0		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000214)|OV - Ovarian serous cystadenocarcinoma(262;0.00985)		AGTACCGCCACAGGCCCTGGT	0.667		NaN											0	0	0	0.00333	0	23	85									
DPRX	503834	broad.mit.edu	37	19	54139969	54139969	+	Silent	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:54139969G>C	uc002qcf.1	+	3	354	c.303G>C	c.(301-303)CTG>CTC	p.L101L		NM_001012728	NP_001012746	A6NFQ7	DPRX_HUMAN	divergent-paired related homeobox	101						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.013)		GTGTCGGCCTGAGAAATGCAG	0.527		NaN											0	0	0	0.006999	0	43	85									
DPRX	503834	broad.mit.edu	37	19	54139992	54139992	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:54139992G>C	uc002qcf.1	+	3	377	c.326G>C	c.(325-327)AGA>ACA	p.R109T		NM_001012728	NP_001012746	A6NFQ7	DPRX_HUMAN	divergent-paired related homeobox	109						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.013)		ACACTACCCAGATTGCCCAAC	0.542		NaN											0	0	0	0.00874	0	44	81									
DPRX	503834	broad.mit.edu	37	19	54140199	54140199	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:54140199C>G	uc002qcf.1	+	3	584	c.533C>G	c.(532-534)TCT>TGT	p.S178C		NM_001012728	NP_001012746	A6NFQ7	DPRX_HUMAN	divergent-paired related homeobox	178						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.013)		AGCTTCCATTCTGGCTCTCCT	0.388		NaN											0	0	0	0.008291	0	9	176									
VSTM1	284415	broad.mit.edu	37	19	54545425	54545425	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:54545425C>G	uc002qcw.3	-	6	689	c.513G>C	c.(511-513)AAG>AAC	p.K171N	VSTM1_uc010erb.2_Intron|VSTM1_uc002qcx.3_Missense_Mutation_p.K140N	NM_198481	NP_940883	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	171						integral to membrane					0	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		GCATCTACCTCTTGGTGGATT	0.507		NaN											0	0	0	0.012213	0	31	146									
ZNF587	84914	broad.mit.edu	37	19	58370965	58370965	+	Silent	SNP	C	C	T	rs146642070		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:58370965C>T	uc002qql.2	+	3	1323	c.1185C>T	c.(1183-1185)CTC>CTT	p.L395L	ZNF587_uc002qqb.2_Silent_p.L352L|ZNF587_uc010yhh.1_Silent_p.L352L|ZNF587_uc002qqi.1_Silent_p.L352L|ZNF587_uc002qqj.1_RNA|ZNF814_uc002qqk.2_Intron|ZNF587_uc010yhk.1_Silent_p.L394L	NM_032828	NP_116217	Q96SQ5	ZN587_HUMAN	zinc finger protein 587	395	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)		AGGGCAACCTCGTTCACCATC	0.468		NaN											0	0	0	0.01441	0	103	129									
CHMP2A	27243	broad.mit.edu	37	19	59063424	59063424	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:59063424C>T	uc002qti.2	-	3	903	c.477G>A	c.(475-477)GAG>GAA	p.E159E	CHMP2A_uc002qtj.2_Silent_p.E159E|CHMP2A_uc002qtk.2_Silent_p.E159E	NM_198426	NP_940818	O43633	CHM2A_HUMAN	chromatin modifying protein 2A	159	Interaction with VPS4B.				cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein domain specific binding				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		CCCCATACCTCTCCTCTTCAT	0.517		NaN											0	0	0	0.010729	0	11	193									
CHMP2A	27243	broad.mit.edu	37	19	59063429	59063429	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr19:59063429C>T	uc002qti.2	-	3	898	c.472G>A	c.(472-474)GAG>AAG	p.E158K	CHMP2A_uc002qtj.2_Missense_Mutation_p.E158K|CHMP2A_uc002qtk.2_Missense_Mutation_p.E158K	NM_198426	NP_940818	O43633	CHM2A_HUMAN	chromatin modifying protein 2A	158	Interaction with VPS4B.				cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein domain specific binding				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		TACCTCTCCTCTTCATCTTCC	0.512		NaN											0	0	0	0.001855	0	12	204									
MYT1L	23040	broad.mit.edu	37	2	1906969	1906969	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:1906969C>G	uc002qxe.2	-	14	2742	c.1915G>C	c.(1915-1917)GAG>CAG	p.E639Q	MYT1L_uc002qxd.2_Missense_Mutation_p.E637Q|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	639					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GAATATTTCTCGAGCTCCTTG	0.498		NaN											0	0	0	0.00308	0	8	81									
MYT1L	23040	broad.mit.edu	37	2	1926917	1926917	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:1926917G>A	uc002qxe.2	-	10	1451	c.624C>T	c.(622-624)CTC>CTT	p.L208L	MYT1L_uc002qxd.2_Silent_p.L208L|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	208					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CGATTTTGCCGAGGTTTAACA	0.423		NaN											0	0	0	0.007413	0	19	50									
KIDINS220	57498	broad.mit.edu	37	2	8870993	8870993	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:8870993G>A	uc002qzc.2	-	30	5355	c.5173C>T	c.(5173-5175)CAG>TAG	p.Q1725*	KIDINS220_uc010yiv.1_Intron|KIDINS220_uc002qzd.2_Nonsense_Mutation_p.Q1626*|KIDINS220_uc002qzb.2_Nonsense_Mutation_p.Q579*	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	1725	Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TTCTCATTCTGAATAGTGGTT	0.463		NaN											0	0	0	0.010504	0	19	61									
TAF1B	9014	broad.mit.edu	37	2	10045054	10045054	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:10045054C>T	uc002qzz.2	+	9	974	c.874C>T	c.(874-876)CGT>TGT	p.R292C	TAF1B_uc010exc.2_Missense_Mutation_p.R292C|TAF1B_uc002qzy.3_Missense_Mutation_p.R292C|TAF1B_uc010yja.1_Missense_Mutation_p.R37C|TAF1B_uc010exd.2_Missense_Mutation_p.R37C	NM_005680	NP_005671	Q53T94	TAF1B_HUMAN	TBP-associated factor 1B	292					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|breast(1)|pancreas(1)	3	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					AGATTTGCCTCGTTTTCCAGA	0.378		NaN											0	0	0	0.004482	0	8	136									
APOB	338	broad.mit.edu	37	2	21233505	21233505	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:21233505C>T	uc002red.2	-	26	6363	c.6235G>A	c.(6235-6237)GAA>AAA	p.E2079K		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2079	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCAAAATATTCTTGCAAGGTC	0.343		NaN											0	0	0	0.012319	0	22	79									
ITSN2	50618	broad.mit.edu	37	2	24483991	24483991	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:24483991G>A	uc002rfe.2	-	22	2924	c.2666C>T	c.(2665-2667)TCA>TTA	p.S889L	ITSN2_uc002rff.2_Missense_Mutation_p.S862L|ITSN2_uc002rfg.2_Missense_Mutation_p.S889L	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	889					endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATGAATAGGTGATACAGATCC	0.343		NaN											0	0	0	0.012319	0	20	49									
NCOA1	8648	broad.mit.edu	37	2	24896249	24896249	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:24896249G>A	uc002rfk.2	+	5	529	c.271G>A	c.(271-273)GAT>AAT	p.D91N	NCOA1_uc010eye.2_Missense_Mutation_p.D91N|NCOA1_uc002rfi.2_5'UTR|NCOA1_uc002rfj.2_Missense_Mutation_p.D91N|NCOA1_uc002rfl.2_Missense_Mutation_p.D91N	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	91									PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATCAACAACTGATGACGATGT	0.348		NaN	T	PAX3	alveolar rhadomyosarcoma								0	0	0	0.004656	0	24	103									
NCOA1	8648	broad.mit.edu	37	2	24896300	24896300	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:24896300G>C	uc002rfk.2	+	5	580	c.322G>C	c.(322-324)GAA>CAA	p.E108Q	NCOA1_uc010eye.2_Missense_Mutation_p.E108Q|NCOA1_uc002rfi.2_5'UTR|NCOA1_uc002rfj.2_Missense_Mutation_p.E108Q|NCOA1_uc002rfl.2_Missense_Mutation_p.E108Q	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	108									PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGAGTGATAGAAAAGGAATC	0.338		NaN	T	PAX3	alveolar rhadomyosarcoma								0	0	0	0.012213	0	30	105									
ASXL2	55252	broad.mit.edu	37	2	26029159	26029159	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:26029159G>A	uc002rgs.2	-	3	412	c.191C>T	c.(190-192)TCC>TTC	p.S64F		NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	64					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTCACCTCTGGAGTTTGTGTG	0.388		NaN											0	0	0	0.000602	0	4	32									
DPY30	84661	broad.mit.edu	37	2	32264363	32264363	+	Silent	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:32264363G>C	uc002roa.1	-	3	288	c.69C>G	c.(67-69)CTC>CTG	p.L23L	MEMO1_uc010ymv.1_RNA|DPY30_uc002rob.1_Silent_p.L23L	NM_032574	NP_115963	Q9C005	DPY30_HUMAN	dpy-30-like protein	23					endosome transport|histone H3-K4 methylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Set1C/COMPASS complex|trans-Golgi network	protein homodimerization activity				0	Acute lymphoblastic leukemia(172;0.155)					CGTTGTCTGTGAGACCGTACT	0.493		NaN											0	0	0	0.00499	0	16	112									
VIT	5212	broad.mit.edu	37	2	36994259	36994259	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:36994259G>A	uc002rpl.2	+	7	731	c.510G>A	c.(508-510)CAG>CAA	p.Q170Q	VIT_uc010ynf.1_Intron|VIT_uc002rpm.2_Silent_p.Q163Q|VIT_uc010ezv.2_Silent_p.Q163Q|VIT_uc010ezw.2_Silent_p.Q163Q	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	170						proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				AAGCCTATCAGAGGCCACCTA	0.468		NaN											0	0	0	0.006214	0	8	33									
ARHGAP25	9938	broad.mit.edu	37	2	69045056	69045056	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:69045056C>T	uc002seu.2	+	8	1294	c.930C>T	c.(928-930)GAC>GAT	p.D310D	ARHGAP25_uc010fdg.2_Silent_p.D311D|ARHGAP25_uc010yql.1_Silent_p.D271D|ARHGAP25_uc002sev.2_Silent_p.D304D|ARHGAP25_uc002sew.2_Silent_p.D303D|ARHGAP25_uc002sex.2_Silent_p.D304D|ARHGAP25_uc010fdh.1_RNA|ARHGAP25_uc002sey.2_Silent_p.D37D	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	310	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						TGAGTGTGGACAACCTGGCTA	0.488		NaN											0	0	0	0.004656	0	27	37									
TACR1	6869	broad.mit.edu	37	2	75280808	75280808	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:75280808C>T	uc002sng.2	-	3	1244	c.659G>A	c.(658-660)GGA>GAA	p.G220E	TACR1_uc002snh.2_Missense_Mutation_p.G220E	NM_001058	NP_001049	P25103	NK1R_HUMAN	tachykinin receptor 1 isoform long	220	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|detection of abiotic stimulus|mechanosensory behavior	integral to plasma membrane	protein binding			ovary(1)	1					Aprepitant(DB00673)|Ketamine(DB01221)|Vapreotide(DB04894)	TAGTGTGATTCCCACTACGGT	0.552		NaN									OREG0014726	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	7	44									
LRRTM1	347730	broad.mit.edu	37	2	80529917	80529917	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:80529917G>A	uc002sok.1	-	2	1298	c.1028C>T	c.(1027-1029)GCC>GTC	p.A343V	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	343	LRRCT.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						CTCCGGGCTGGCGCACTGCAA	0.677		NaN								HNSCC(69;0.2)			0	0	0	0.00308	0	8	13									
TGOLN2	10618	broad.mit.edu	37	2	85554310	85554310	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:85554310G>A	uc010fgd.1	-	2	834	c.545C>T	c.(544-546)TCG>TTG	p.S182L	TGOLN2_uc002soz.2_Missense_Mutation_p.S182L|TGOLN2_uc002spa.2_RNA|TGOLN2_uc002spb.2_Missense_Mutation_p.S182L|TGOLN2_uc002spc.1_Missense_Mutation_p.S182L	NM_006464	NP_006455	O43493	TGON2_HUMAN	trans-golgi network protein 2	182	Extracellular (Potential).|10.|14 X 14 AA tandem repeats.					integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding				0						GTCCGCACCCGACTTATTAGG	0.592		NaN											0	0	0	0.01441	0	217	378									
PTCD3	55037	broad.mit.edu	37	2	86364195	86364195	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:86364195C>T	uc002sqw.2	+	23	1977	c.1911C>T	c.(1909-1911)TTC>TTT	p.F637F	PTCD3_uc002sqx.1_Silent_p.F227F	NM_017952	NP_060422	Q96EY7	PTCD3_HUMAN	pentatricopeptide repeat domain 3 precursor	637						mitochondrion	protein binding			ovary(1)	1						CAAGTGCCTTCAGCTTACCTA	0.438		NaN											0	0	0	0.004656	0	27	169									
ACTR1B	10120	broad.mit.edu	37	2	98274919	98274919	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:98274919C>T	uc002syb.2	-	6	836	c.628G>A	c.(628-630)GAG>AAG	p.E210K		NM_005735	NP_005726	P42025	ACTY_HUMAN	ARP1 actin-related protein 1 homolog B,	210						centrosome|dynactin complex	ATP binding|protein binding			skin(1)	1						ACCTCAAACTCAGCCGAGGTA	0.617		NaN											0	0	0	0.004482	0	7	30									
AFF3	3899	broad.mit.edu	37	2	100210735	100210735	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:100210735G>A	uc002tag.2	-	14	1624	c.1388C>T	c.(1387-1389)TCT>TTT	p.S463F	AFF3_uc002taf.2_Missense_Mutation_p.S488F|AFF3_uc010fiq.1_Missense_Mutation_p.S463F|AFF3_uc010yvr.1_Missense_Mutation_p.S616F|AFF3_uc002tah.1_Missense_Mutation_p.S488F	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	463					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						CCACTTGTTAGAGGATGCCGG	0.443		NaN											0	0	0	0.010818	0	32	214									
SEPT10	151011	broad.mit.edu	37	2	110332202	110332202	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:110332202G>C	uc002tew.2	-	5	935	c.556C>G	c.(556-558)CTG>GTG	p.L186V	SEPT10_uc010ywu.1_Intron|SEPT10_uc002tex.2_Missense_Mutation_p.L163V|SEPT10_uc002tey.2_Missense_Mutation_p.L186V|SEPT10_uc010ywv.1_Missense_Mutation_p.L52V|SEPT10_uc002tev.1_5'UTR|SEPT10_uc010fjo.2_RNA	NM_144710	NP_653311	Q9P0V9	SEP10_HUMAN	septin 10 isoform 1	186					cell cycle|cell division	septin complex	GTP binding				0						AGTGTCTTCAGAGAGTGGCCT	0.383		NaN											0	0	0	0.007413	0	16	66									
TMEM87B	84910	broad.mit.edu	37	2	112858208	112858208	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:112858208C>T	uc002thm.2	+	15	1755	c.1386C>T	c.(1384-1386)TTC>TTT	p.F462F		NM_032824	NP_116213	Q96K49	TM87B_HUMAN	transmembrane protein 87B precursor	462						integral to membrane					0						GATATGCCTTCATGCCCTTAA	0.274		NaN											0	0	0	0.00308	0	7	68									
EN1	2019	broad.mit.edu	37	2	119600601	119600601	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:119600601G>C	uc002tlm.2	-	2	2108	c.1092C>G	c.(1090-1092)ATC>ATG	p.I364M		NM_001426	NP_001417	Q05925	HME1_HUMAN	engrailed homeobox 1	364					skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(1)	2						GGCCGTTCTTGATGCCTGTGG	0.587		NaN											0	0	0	0.00308	0	8	43									
CLASP1	23332	broad.mit.edu	37	2	122122825	122122825	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:122122825G>A	uc002tnc.2	-	35	4312	c.3922C>T	c.(3922-3924)CTG>TTG	p.L1308L	CLASP1_uc010yyv.1_Silent_p.L354L|CLASP1_uc002tmz.2_Silent_p.L393L|CLASP1_uc002tna.2_Silent_p.L354L|CLASP1_uc010yyw.1_RNA|CLASP1_uc002tnb.2_RNA|CLASP1_uc010yyx.1_RNA|CLASP1_uc010yyy.1_RNA|CLASP1_uc010yyz.1_Silent_p.L1249L|CLASP1_uc010yza.1_Silent_p.L1241L|CLASP1_uc010yzb.1_RNA|CLASP1_uc010yzc.1_RNA|CLASP1_uc002tmy.2_Silent_p.L144L|CLASP1_uc002tnf.2_Silent_p.L210L	NM_015282	NP_056097	Q7Z460	CLAP1_HUMAN	CLIP-associating protein 1 isoform 1	1308	Localization to kinetochores.|Interaction with PHLDB2 and RSN.|Potential.|Interaction with CLIP2 (By similarity).				axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			ovary(1)|central_nervous_system(1)	2	Renal(3;0.0496)					AGCTCTTTCAGAAGGTCAGCC	0.572		NaN											0	0	0	0.004672	0	3	21									
POTEF	728378	broad.mit.edu	37	2	130843513	130843513	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:130843513C>G	uc010fmh.2	-	15	2052	c.1652G>C	c.(1651-1653)GGA>GCA	p.G551A		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	551						cell cortex	ATP binding			skin(3)|ovary(2)	5						TTCTGGGAATCCGACATGAGT	0.398		NaN											0	0	0	0.013726	0	32	16									
LRP1B	53353	broad.mit.edu	37	2	141533803	141533803	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:141533803C>T	uc002tvj.1	-	33	6336	c.5364G>A	c.(5362-5364)AAG>AAA	p.K1788K		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1788	Extracellular (Potential).|LDL-receptor class B 18.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACCACAGTTTCTTATCTAGAA	0.338		NaN								TSP Lung(27;0.18)			0	0	0	0.00308	0	8	34									
TANC1	85461	broad.mit.edu	37	2	160050867	160050867	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:160050867G>C	uc002uag.2	+	17	3116	c.2842G>C	c.(2842-2844)GAG>CAG	p.E948Q	TANC1_uc010zcm.1_Missense_Mutation_p.E940Q|TANC1_uc010fom.1_Missense_Mutation_p.E754Q	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	948	ANK 2.					cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						CCTTGGCCACGAGGAAGTTGT	0.557		NaN											0	0	0	0.00308	0	6	75									
MARCH7	64844	broad.mit.edu	37	2	160609027	160609027	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:160609027G>C	uc002uax.2	+	6	1850	c.1728G>C	c.(1726-1728)TTG>TTC	p.L576F	MARCH7_uc010foq.2_Missense_Mutation_p.L576F|MARCH7_uc010zcn.1_Missense_Mutation_p.L520F|MARCH7_uc010for.2_Missense_Mutation_p.L538F|MARCH7_uc002uay.2_RNA	NM_022826	NP_073737	Q9H992	MARH7_HUMAN	axotrophin	576	RING-CH-type.						ligase activity|zinc ion binding				0						CAGGAAGTTTGCAGTATGTCC	0.383		NaN											0	0	0	0.01441	0	48	121									
DHRS9	10170	broad.mit.edu	37	2	169939910	169939910	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:169939910G>A	uc002uep.2	+	6	1889	c.385G>A	c.(385-387)GAC>AAC	p.D129N	DHRS9_uc002ueq.2_Missense_Mutation_p.D129N|DHRS9_uc010zdc.1_Missense_Mutation_p.D189N|DHRS9_uc010zdd.1_Missense_Mutation_p.D129N|DHRS9_uc010zde.1_Missense_Mutation_p.D129N	NM_005771	NP_005762	Q9BPW9	DHRS9_HUMAN	NADP-dependent retinol dehydrogenase/reductase	129					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity				0						GACACTAGAGGACTACAGAGA	0.468		NaN											0	0	0	0.003163	0	16	119									
KBTBD10	10324	broad.mit.edu	37	2	170366331	170366331	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:170366331C>T	uc002ueu.1	+	1	120	c.43C>T	c.(43-45)CAA>TAA	p.Q15*	KBTBD10_uc010zdh.1_Intron	NM_006063	NP_006054	O60662	KBTBA_HUMAN	kelch repeat and BTB (POZ) domain containing 10	15					striated muscle contraction	centrosome|nucleolus|plasma membrane|pseudopodium|ruffle					0						GCGGCTTTACCAATCCACCCT	0.488		NaN											0	0	0	0.013114	0	47	102									
GAD1	2571	broad.mit.edu	37	2	171678617	171678617	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:171678617G>A	uc002ugi.2	+	3	525	c.103G>A	c.(103-105)GTG>ATG	p.V35M	GAD1_uc002ugh.2_Missense_Mutation_p.V35M	NM_000817	NP_000808	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 isoform GAD67	35					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(1)	1					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CTGGTGCGGCGTGGCCCATGG	0.627		NaN											0	0	0	0.009096	0	4	12									
PLEKHA3	65977	broad.mit.edu	37	2	179368594	179368594	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:179368594C>T	uc002umn.2	+	8	1281	c.883C>T	c.(883-885)CTT>TTT	p.L295F		NM_019091	NP_061964	Q9HB20	PKHA3_HUMAN	pleckstrin homology domain containing, family A	295						cytoplasm|membrane				ovary(1)|kidney(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.0266)|all cancers(119;0.0865)			AGAAGATACTCTTCCATCCTT	0.368		NaN											0	0	0	0.004482	0	9	63									
TTN	7273	broad.mit.edu	37	2	179421813	179421813	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:179421813C>A	uc010zfg.1	-	279	80588	c.80364G>T	c.(80362-80364)TGG>TGT	p.W26788C	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.W20483C|TTN_uc010zfi.1_Missense_Mutation_p.W20416C|TTN_uc010zfj.1_Missense_Mutation_p.W20291C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27715							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGGTTGTTGCCATGAAAGGC	0.443		NaN											1	0	1.5739e-10	0.004007	1.67292e-10	15	17									
TTN	7273	broad.mit.edu	37	2	179641476	179641476	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:179641476G>C	uc010zfg.1	-	28	5339	c.5115C>G	c.(5113-5115)TTC>TTG	p.F1705L	TTN_uc010zfh.1_Missense_Mutation_p.F1659L|TTN_uc010zfi.1_Missense_Mutation_p.F1659L|TTN_uc010zfj.1_Missense_Mutation_p.F1659L|TTN_uc002unb.2_Missense_Mutation_p.F1705L|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1705							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTTTTTCTTGAAAAATGGTT	0.483		NaN											0	0	0	0.00308	0	8	57									
ZNF804A	91752	broad.mit.edu	37	2	185803228	185803228	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:185803228G>A	uc002uph.2	+	4	3699	c.3105G>A	c.(3103-3105)TTG>TTA	p.L1035L		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1035						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						AAGCATTATTGATCCCACTAG	0.413		NaN											0	0	0	0.004878	0	40	65									
WDR75	84128	broad.mit.edu	37	2	190338996	190338996	+	Missense_Mutation	SNP	G	G	A	rs116046757	byFrequency	TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:190338996G>A	uc002uql.1	+	19	2194	c.2134G>A	c.(2134-2136)GAA>AAA	p.E712K	WDR75_uc002uqm.1_Missense_Mutation_p.E648K|WDR75_uc002uqn.1_Missense_Mutation_p.E490K|WDR75_uc002uqo.1_Missense_Mutation_p.E490K	NM_032168	NP_115544	Q8IWA0	WDR75_HUMAN	WD repeat domain 75	712						nucleolus				ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00105)|Epithelial(96;0.0129)|all cancers(119;0.0456)			AAAACTAAACGAAACTTTAGA	0.363		NaN											0	0	0	0.006214	0	10	133									
MYO1B	4430	broad.mit.edu	37	2	192275892	192275892	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:192275892C>T	uc010fsg.2	+	27	3122	c.2867C>T	c.(2866-2868)CCA>CTA	p.P956L	MYO1B_uc002usq.2_Missense_Mutation_p.P898L|MYO1B_uc002usr.2_Missense_Mutation_p.P956L|MYO1B_uc002usu.2_Missense_Mutation_p.P201L|MYO1B_uc002usv.2_Missense_Mutation_p.P72L	NM_001130158	NP_001123630	O43795	MYO1B_HUMAN	myosin IB isoform 1	956						myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			GCTTTATACCCATCTAGGTAT	0.358		NaN											0	0	0	0.012319	0	21	95									
GTF3C3	9330	broad.mit.edu	37	2	197654765	197654765	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:197654765G>A	uc002uts.2	-	5	655	c.565C>T	c.(565-567)CTA>TTA	p.L189L	GTF3C3_uc010zgu.1_Silent_p.L189L|GTF3C3_uc002utu.2_Silent_p.L189L	NM_012086	NP_036218	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide	189	TPR 2.					transcription factor TFIIIC complex	DNA binding|protein binding			ovary(3)|breast(3)|pancreas(1)	7						ATCATGGCTAGAGTAGAGAAT	0.403		NaN											0	0	0	0.010729	0	11	54									
FN1	2335	broad.mit.edu	37	2	216272903	216272903	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:216272903C>T	uc002vfa.2	-	17	2712	c.2446G>A	c.(2446-2448)GAC>AAC	p.D816N	FN1_uc002vfb.2_Missense_Mutation_p.D816N|FN1_uc002vfc.2_Missense_Mutation_p.D816N|FN1_uc002vfd.2_Missense_Mutation_p.D816N|FN1_uc002vfe.2_Missense_Mutation_p.D816N|FN1_uc002vff.2_Missense_Mutation_p.D816N|FN1_uc002vfg.2_Missense_Mutation_p.D816N|FN1_uc002vfh.2_Missense_Mutation_p.D816N|FN1_uc002vfi.2_Missense_Mutation_p.D816N|FN1_uc002vfj.2_Missense_Mutation_p.D816N	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	816	Fibronectin type-III 3.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACAGTCGTGTCAGGAGGGGCA	0.502		NaN											0	0	0	0.000602	0	5	80									
SPHKAP	80309	broad.mit.edu	37	2	228881142	228881142	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:228881142C>T	uc002vpq.2	-	7	4475	c.4428G>A	c.(4426-4428)GTG>GTA	p.V1476V	SPHKAP_uc002vpp.2_Silent_p.V1476V|SPHKAP_uc010zlx.1_Silent_p.V1476V	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1476						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GACAAGCGCTCACGGCTGTGT	0.463		NaN											0	0	0	0.00333	0	23	107									
SP100	6672	broad.mit.edu	37	2	231327168	231327168	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr2:231327168C>G	uc002vqt.2	+	10	1133	c.992C>G	c.(991-993)TCT>TGT	p.S331C	SP100_uc002vqs.2_Missense_Mutation_p.S331C|SP100_uc002vqu.1_Missense_Mutation_p.S331C|SP100_uc010zmb.1_Missense_Mutation_p.S331C|SP100_uc002vqq.1_Missense_Mutation_p.S331C|SP100_uc002vqr.1_Missense_Mutation_p.S306C|SP100_uc010zmc.1_Missense_Mutation_p.S306C|SP100_uc002vqv.1_Missense_Mutation_p.S295C	NM_003113	NP_003104	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 2	331					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AGTGAGGACTCTGAAGGATCC	0.502		NaN											0	0	0	0.00278	0	21	23									
MAVS	57506	broad.mit.edu	37	20	3838392	3838392	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:3838392G>A	uc002wjw.3	+	3	397	c.228G>A	c.(226-228)CTG>CTA	p.L76L	MAVS_uc002wjv.2_Silent_p.L76L|MAVS_uc010zqn.1_Silent_p.L76L|MAVS_uc002wjx.3_Intron|MAVS_uc002wjy.3_5'UTR	NM_020746	NP_065797	Q7Z434	MAVS_HUMAN	virus-induced signaling adapter	76	Cytoplasmic (Probable).|Required for interaction with NLRX1.|CARD.				activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity				0						TTGCGGCACTGAGGGGCTGTG	0.637		NaN											0	0	0	0.013537	0	13	112									
MAVS	57506	broad.mit.edu	37	20	3838402	3838402	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:3838402G>A	uc002wjw.3	+	3	407	c.238G>A	c.(238-240)GAG>AAG	p.E80K	MAVS_uc002wjv.2_Missense_Mutation_p.E80K|MAVS_uc010zqn.1_Missense_Mutation_p.E80K|MAVS_uc002wjx.3_Intron|MAVS_uc002wjy.3_5'UTR	NM_020746	NP_065797	Q7Z434	MAVS_HUMAN	virus-induced signaling adapter	80	Cytoplasmic (Probable).				activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity				0						GAGGGGCTGTGAGCTAGTTGA	0.632		NaN											0	0	0	0.001855	0	13	109									
MAVS	57506	broad.mit.edu	37	20	3842053	3842053	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:3842053G>A	uc002wjw.3	+	4	536	c.367G>A	c.(367-369)GCT>ACT	p.A123T	MAVS_uc010zqn.1_Intron|MAVS_uc002wjx.3_5'UTR|MAVS_uc002wjy.3_Intron	NM_020746	NP_065797	Q7Z434	MAVS_HUMAN	virus-induced signaling adapter	123	Pro-rich.|Cytoplasmic (Probable).				activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity				0						CCCCACACCTGCTGCGGCCCA	0.627		NaN											0	0	0	0.013537	0	12	100									
MAVS	57506	broad.mit.edu	37	20	3842137	3842137	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:3842137G>C	uc002wjw.3	+	4	620	c.451G>C	c.(451-453)GAG>CAG	p.E151Q	MAVS_uc010zqn.1_Intron|MAVS_uc002wjx.3_Missense_Mutation_p.E10Q|MAVS_uc002wjy.3_Intron	NM_020746	NP_065797	Q7Z434	MAVS_HUMAN	virus-induced signaling adapter	151	Pro-rich.|Cytoplasmic (Probable).				activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity				0						CCAGGCGCCAGAGTCCCCAGG	0.592		NaN											0	0	0	0.001984	0	6	65									
PANK2	80025	broad.mit.edu	37	20	3869936	3869936	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:3869936G>A	uc002wkc.2	+	1	195	c.189G>A	c.(187-189)CCG>CCA	p.P63P	uc002wjz.1_5'Flank|uc002wka.1_5'Flank|PANK2_uc002wkb.2_Intron|PANK2_uc010gbd.1_RNA|PANK2_uc002wkd.2_RNA|PANK2_uc002wke.2_5'Flank|PANK2_uc002wkf.2_5'Flank	NM_153638	NP_705902	Q9BZ23	PANK2_HUMAN	pantothenate kinase 2 isoform 1 preproprotein	63					cell death|coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial intermembrane space|nucleus	ATP binding|pantothenate kinase activity|protein binding				0						TTAGGGAGCCGACTGGACGCG	0.692		NaN											0	0	0	0.004672	0	3	5									
PLCB4	5332	broad.mit.edu	37	20	9459591	9459591	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:9459591G>A	uc002wnf.2	+	37	3619	c.3483G>A	c.(3481-3483)GTG>GTA	p.V1161V	PLCB4_uc010gbx.2_Silent_p.V1173V|PLCB4_uc002wne.2_Missense_Mutation_p.E1174K|PLCB4_uc002wnh.2_Silent_p.V1008V	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	1161					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						AGCAGATGGTGAAATTGGAAG	0.458		NaN											0	0	0	0.00308	0	8	36									
SNAP25	6616	broad.mit.edu	37	20	10279959	10279959	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:10279959G>C	uc002wnq.1	+	7	663	c.451G>C	c.(451-453)GAG>CAG	p.E151Q	SNAP25_uc002wnr.1_Missense_Mutation_p.E151Q|SNAP25_uc002wns.1_Missense_Mutation_p.E88Q|SNAP25_uc010gca.1_Missense_Mutation_p.E151Q|SNAP25_uc010gcb.1_Missense_Mutation_p.E88Q|SNAP25_uc010gcc.1_Missense_Mutation_p.E45Q	NM_130811	NP_570824	P60880	SNP25_HUMAN	synaptosomal-associated protein 25 isoform	151	t-SNARE coiled-coil homology 2.				energy reserve metabolic process|glutamate secretion|neurotransmitter uptake|synaptic vesicle docking involved in exocytosis	cell junction|growth cone|perinuclear region of cytoplasm|synapse|synaptosome				skin(2)	2					Botulinum Toxin Type A(DB00083)	TGAAAACCTAGAGCAGGTGAG	0.468		NaN											0	0	0	0.01441	0	51	167									
TASP1	55617	broad.mit.edu	37	20	13514765	13514765	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:13514765G>A	uc002woi.2	-	9	816	c.699C>T	c.(697-699)GAC>GAT	p.D233D	TASP1_uc010zri.1_Intron|TASP1_uc002woh.2_Silent_p.D210D|TASP1_uc010zrj.1_RNA	NM_017714	NP_060184	Q9H6P5	TASP1_HUMAN	taspase 1 precursor	233				D->A: 0.1% enzymatic activity; no intramolecular processing.	asparagine catabolic process via L-aspartate|positive regulation of transcription, DNA-dependent|protein maturation		threonine-type endopeptidase activity				0						CGCCTACCGTGTCCAAAGTGC	0.512		NaN											0	0	0	0.003755	0	35	109									
ZNF133	7692	broad.mit.edu	37	20	18297183	18297183	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:18297183C>G	uc010gcq.2	+	5	1993	c.1688C>G	c.(1687-1689)TCA>TGA	p.S563*	ZNF133_uc010zrv.1_Nonsense_Mutation_p.S566*|ZNF133_uc010zrw.1_Nonsense_Mutation_p.S500*|ZNF133_uc010gcr.2_Nonsense_Mutation_p.S563*|ZNF133_uc010zrx.1_Nonsense_Mutation_p.S468*|ZNF133_uc002wql.3_Nonsense_Mutation_p.S562*|ZNF133_uc010gcs.2_Nonsense_Mutation_p.S562*|ZNF133_uc010zry.1_Nonsense_Mutation_p.S468*|ZNF133_uc002wqm.2_Nonsense_Mutation_p.S563*	NM_003434	NP_003425	P52736	ZN133_HUMAN	zinc finger protein 133	563	C2H2-type 13.					nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|pancreas(1)	2						GGCAATAAGTCAGCTCTAATT	0.542		NaN											0	0	0	0.00278	0	23	51									
MYLK2	85366	broad.mit.edu	37	20	30409372	30409372	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:30409372G>A	uc002wwq.2	+	4	706	c.604G>A	c.(604-606)GAG>AAG	p.E202K		NM_033118	NP_149109	Q9H1R3	MYLK2_HUMAN	skeletal myosin light chain kinase	202					cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			lung(2)|skin(2)|ovary(1)|central_nervous_system(1)	6			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			CATCCTGGCAGAGAGCCAGAA	0.597		NaN											0	0	0	0.00333	0	26	63									
TGM2	7052	broad.mit.edu	37	20	36793594	36793594	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:36793594C>T	uc002xhr.2	-	1	107	c.7G>A	c.(7-9)GAG>AAG	p.E3K	TGM2_uc010zvx.1_Missense_Mutation_p.E3K|TGM2_uc010zvy.1_Missense_Mutation_p.E3K|TGM2_uc002xhs.1_Missense_Mutation_p.E3K|TGM2_uc002xht.2_Missense_Mutation_p.E3K|TGM2_uc002xhu.3_Missense_Mutation_p.E3K	NM_004613	NP_004604	P21980	TGM2_HUMAN	transglutaminase 2 isoform a	3					apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			large_intestine(1)|lung(1)|ovary(1)	3		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	TACTCACCCTCGGCCATGGTC	0.687		NaN											0	0	0	0.010504	0	18	24									
L3MBTL	26013	broad.mit.edu	37	20	42144735	42144735	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:42144735G>C	uc010zwh.1	+	7	760	c.714G>C	c.(712-714)GAG>GAC	p.E238D	L3MBTL_uc010ggk.1_Missense_Mutation_p.E170D|L3MBTL_uc002xkl.2_Missense_Mutation_p.E170D|L3MBTL_uc002xkm.2_Missense_Mutation_p.E170D|L3MBTL_uc010ggl.2_Missense_Mutation_p.E170D	NM_015478	NP_056293	Q9Y468	LMBL1_HUMAN	l(3)mbt-like isoform I	170					chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			TTCTACAGGAGAAGCAAGAAG	0.577		NaN											0	0	0	0.001984	0	6	33									
WFDC10A	140832	broad.mit.edu	37	20	44258532	44258532	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:44258532A>T	uc002xoz.2	+	1	148	c.80A>T	c.(79-81)AAG>ATG	p.K27M	WFDC9_uc002xoy.2_Intron	NM_080753	NP_542791	Q9H1F0	WF10A_HUMAN	WAP four-disulfide core domain 10A precursor	27						extracellular region	serine-type endopeptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				CGTGACAAGAAGAGGATGCAG	0.587		NaN									OREG0025983	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001168	0	4	40									
SLC2A10	81031	broad.mit.edu	37	20	45354112	45354112	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:45354112G>A	uc002xsl.2	+	2	534	c.437G>A	c.(436-438)GGC>GAC	p.G146D		NM_030777	NP_110404	O95528	GTR10_HUMAN	solute carrier family 2 member 10	146	Helical; Name=5; (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				ATCACCGTGGGCATCCTGCTC	0.622		NaN											0	0	0	0.010504	0	20	99									
MOCS3	27304	broad.mit.edu	37	20	49576560	49576560	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:49576560G>A	uc002xvy.1	+	1	1198	c.1181G>A	c.(1180-1182)TGG>TAG	p.W394*	DPM1_uc002xvw.1_5'Flank|DPM1_uc002xvx.1_5'Flank	NM_014484	NP_055299	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	394	Rhodanese.				enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			skin(2)|ovary(1)	3						GAAGCAATCTGGGAAGAGAAG	0.498		NaN											0	0	0	0.01441	0	91	135									
GATA5	140628	broad.mit.edu	37	20	61040029	61040029	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:61040029C>A	uc002ycx.1	-	7	1119	c.1057G>T	c.(1057-1059)GAC>TAC	p.D353Y		NM_080473	NP_536721	Q9BWX5	GATA5_HUMAN	GATA binding protein 5	353					blood coagulation|intestinal epithelial cell differentiation|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding				0	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;3.08e-06)			GCAAGAGAGTCATCCTCCTGG	0.672		NaN											1	0	6.72482e-11	0.003163	7.17166e-11	14	24									
PRIC285	85441	broad.mit.edu	37	20	62194088	62194088	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr20:62194088G>A	uc002yfm.2	-	9	6979	c.6087C>T	c.(6085-6087)CTC>CTT	p.L2029L	PRIC285_uc002yfl.1_Silent_p.L1460L	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	2029					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			GGCCAGGGCCGAGGCTGCTGG	0.697		NaN											0	0	0	0.000602	0	5	6									
ATP5J	522	broad.mit.edu	37	21	27101968	27101968	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr21:27101968C>A	uc002yls.2	-	2	811	c.138G>T	c.(136-138)AAG>AAT	p.K46N	ATP5J_uc002ylt.2_Missense_Mutation_p.K46N|ATP5J_uc002ylu.2_Missense_Mutation_p.K46N|ATP5J_uc002ylv.2_Missense_Mutation_p.K54N|ATP5J_uc002ylw.2_Missense_Mutation_p.K46N	NM_001685	NP_001676	P18859	ATP5J_HUMAN	ATP synthase, H+ transporting, mitochondrial F0	46					ATP catabolic process|respiratory electron transport chain		hydrogen ion transmembrane transporter activity				0						ATTCTCTAATCTTGTCCACAA	0.348		NaN											1	0	0.00024832	0.009096	0.000253452	4	25									
SFRS15	57466	broad.mit.edu	37	21	33069036	33069036	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr21:33069036C>T	uc002ypd.2	-	8	1231	c.805G>A	c.(805-807)GAT>AAT	p.D269N	SFRS15_uc002ype.2_Missense_Mutation_p.D269N|SFRS15_uc010glu.2_Missense_Mutation_p.D254N|SFRS15_uc002ypf.1_5'UTR	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	269						nucleus	nucleotide binding|RNA binding				0						TCTGGCTCATCATCATAGTCA	0.423		NaN											0	0	0	0.006122	0	17	95									
GCFC1	94104	broad.mit.edu	37	21	34134491	34134491	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr21:34134491C>T	uc002yqn.2	-	4	977	c.787G>A	c.(787-789)GAT>AAT	p.D263N	GCFC1_uc002yqo.2_RNA|GCFC1_uc002yqp.2_Missense_Mutation_p.D263N|GCFC1_uc002yqr.2_Missense_Mutation_p.D263N	NM_016631	NP_057715	Q9Y5B6	GCFC1_HUMAN	GC-rich sequence DNA-binding factor candidate	263						cytosol|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2						TCTTCATCATCACTGGCATCA	0.403		NaN											0	0	0	0.006214	0	8	105									
MX2	4600	broad.mit.edu	37	21	42762521	42762521	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr21:42762521G>A	uc002yzf.1	+	6	866	c.762G>A	c.(760-762)CAG>CAA	p.Q254Q	MX2_uc011aer.1_Intron|MX2_uc002yzg.1_5'UTR	NM_002463	NP_002454	P20592	MX2_HUMAN	myxovirus resistance protein 2	254					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				AGTACATCCAGAGGCAGCAGA	0.557		NaN											0	0	0	0.006999	0	38	111									
DGCR2	9993	broad.mit.edu	37	22	19044633	19044633	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:19044633G>A	uc002zoq.1	-	6	916	c.668C>T	c.(667-669)TCG>TTG	p.S223L	DGCR2_uc002zor.1_5'UTR|DGCR2_uc011agr.1_Missense_Mutation_p.S179L	NM_005137	NP_005128	P98153	IDD_HUMAN	integral membrane protein DGCR2 precursor	223	Extracellular (Potential).|C-type lectin.				cell adhesion|organ morphogenesis	integral to membrane	receptor activity|sugar binding			large_intestine(1)	1	Colorectal(54;0.0993)					AGACATGGCCGAGGCAAAGAT	0.592		NaN											0	0	0	0.009096	0	4	13									
CDC45	8318	broad.mit.edu	37	22	19470241	19470241	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:19470241G>C	uc002zpr.2	+	4	309	c.233G>C	c.(232-234)GGA>GCA	p.G78A	CDC45_uc011agz.1_Missense_Mutation_p.G73A|CDC45_uc011aha.1_Missense_Mutation_p.G78A|CDC45_uc002zps.2_Missense_Mutation_p.G78A|CDC45_uc002zpt.2_Intron	NM_003504	NP_003495	O75419	CDC45_HUMAN	CDC45-like	78					DNA replication checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	centrosome|nucleoplasm	protein binding			lung(1)	1						ATAAACTGTGGAGCTAATGTA	0.373		NaN											0	0	0	0.004482	0	8	132									
ZNF280A	129025	broad.mit.edu	37	22	22869392	22869392	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:22869392G>A	uc002zwe.2	-	2	816	c.563C>T	c.(562-564)CCA>CTA	p.P188L	LOC96610_uc011aim.1_Intron	NM_080740	NP_542778	P59817	Z280A_HUMAN	zinc finger protein 280A	188					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		AGGTACCCCTGGGATTCCATC	0.448		NaN											0	0	0	0.00245	0	13	141									
SMARCB1	6598	broad.mit.edu	37	22	24129380	24129380	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:24129380G>C	uc002zyb.2	+	1	231	c.24G>C	c.(22-24)AAG>AAC	p.K8N	SMARCB1_uc002zyg.2_Missense_Mutation_p.K8N|SMARCB1_uc011ajb.1_Missense_Mutation_p.K8N|SMARCB1_uc002zya.2_Missense_Mutation_p.K8N|SMARCB1_uc002zyc.2_Missense_Mutation_p.K8N|SMARCB1_uc002zyd.2_Missense_Mutation_p.K8N	NM_003073	NP_003064	Q12824	SNF5_HUMAN	SWI/SNF related, matrix associated, actin	8					cell cycle|chromatin remodeling|DNA integration|interspecies interaction between organisms|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|retroviral genome replication|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleolus|nucleoplasm|SWI/SNF complex	p53 binding	p.?(2)		soft_tissue(193)|central_nervous_system(172)|haematopoietic_and_lymphoid_tissue(23)|meninges(5)|skin(5)|bone(4)|ovary(2)|endometrium(1)|lung(1)|pancreas(1)	407		Medulloblastoma(6;2.2e-09)|all_neural(6;2.73e-05)				CGCTGAGCAAGACCTTCGGGC	0.682		NaN	D|N|F|S		malignant rhabdoid 	malignant rhabdoid			Rhabdoid_Predisposition_syndrome|Schwannomatosis				0	0	0	0.008291	0	11	38									
GGT5	2687	broad.mit.edu	37	22	24622208	24622208	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:24622208C>T	uc002zzo.3	-	8	1482	c.1065G>A	c.(1063-1065)GAG>GAA	p.E355E	GGT5_uc002zzp.3_Silent_p.E355E|GGT5_uc002zzr.3_Silent_p.E323E|GGT5_uc002zzq.3_Silent_p.E323E|GGT5_uc011ajm.1_Silent_p.E278E|GGT5_uc011ajn.1_RNA	NM_004121	NP_004112	P36269	GGT5_HUMAN	gamma-glutamyltransferase 5 isoform b	355	Extracellular (Potential).				glutathione biosynthetic process|hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	integral to membrane|plasma membrane	acyltransferase activity|gamma-glutamyltransferase activity			ovary(2)|skin(1)	3						GGGCCAGGGTCTCCCCCAGCA	0.677		NaN											0	0	0	0.001168	0	6	27									
SF3A1	10291	broad.mit.edu	37	22	30735229	30735229	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:30735229C>G	uc003ahl.2	-	10	1519	c.1387G>C	c.(1387-1389)GAG>CAG	p.E463Q		NM_005877	NP_005868	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa isoform 1	463					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			ovary(3)|large_intestine(1)|pancreas(1)	5						AAGCTGCTCTCAATATCCAGA	0.493		NaN											0	0	0	0.008291	0	9	132									
DRG1	4733	broad.mit.edu	37	22	31796663	31796663	+	Missense_Mutation	SNP	C	C	T	rs28369552		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:31796663C>T	uc003aku.2	+	2	231	c.100C>T	c.(100-102)CGT>TGT	p.R34C		NM_004147	NP_004138	Q9Y295	DRG1_HUMAN	developmentally regulated GTP binding protein 1	34					multicellular organismal development|transcription, DNA-dependent	cytoplasm|intermediate filament cytoskeleton|nucleus	GTP binding|transcription factor binding			central_nervous_system(1)	1						GCTTAAGGCTCGTCTTGCTAA	0.458		NaN											0	0	0	0.003755	0	33	50									
APOL1	8542	broad.mit.edu	37	22	36661254	36661254	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:36661254G>A	uc003apf.2	+	6	540	c.372G>A	c.(370-372)ATG>ATA	p.M124I	APOL1_uc011amn.1_Missense_Mutation_p.M1I|APOL1_uc003apc.2_RNA|APOL1_uc003ape.2_Missense_Mutation_p.M140I|APOL1_uc011amo.1_Missense_Mutation_p.M1I|APOL1_uc011amp.1_Missense_Mutation_p.M124I|APOL1_uc011amq.1_Missense_Mutation_p.M106I|APOL1_uc010gwx.2_Missense_Mutation_p.M1I	NM_003661	NP_003652	O14791	APOL1_HUMAN	apolipoprotein L1 isoform a precursor	124					cholesterol metabolic process|cytolysis|innate immune response|killing of cells of other organism|lipid transport|lipoprotein metabolic process	high-density lipoprotein particle|very-low-density lipoprotein particle	chloride channel activity|lipid binding|protein binding			breast(2)|ovary(1)	3						AAATGATCATGAAAGACAAAA	0.413		NaN											0	0	0	0.012319	0	21	68									
MYH9	4627	broad.mit.edu	37	22	36696992	36696992	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:36696992C>T	uc003apg.2	-	22	2974	c.2743G>A	c.(2743-2745)GAG>AAG	p.E915K	MYH9_uc003aph.1_Missense_Mutation_p.E779K	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	915	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						TGGCAGATCTCTTCTAATTCC	0.607		NaN	T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				0	0	0	0.01441	0	54	76									
DMC1	11144	broad.mit.edu	37	22	38916075	38916075	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:38916075C>T	uc003avz.1	-	14	1148	c.973G>A	c.(973-975)GAA>AAA	p.E325K	DMC1_uc011anv.1_Missense_Mutation_p.E270K	NM_007068	NP_008999	Q14565	DMC1_HUMAN	DMC1 dosage suppressor of mck1 homolog	325					reciprocal meiotic recombination	condensed nuclear chromosome	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding			ovary(1)	1	Melanoma(58;0.0286)					AAGGTGGCTTCATTTTCAGGC	0.393		NaN						Homologous_recombination					0	0	0	0.003954	0	21	73									
ENTHD1	150350	broad.mit.edu	37	22	40139834	40139834	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:40139834C>T	uc003ayg.2	-	7	1925	c.1674G>A	c.(1672-1674)GCG>GCA	p.A558A		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	558	Potential.									ovary(2)|skin(1)	3	Melanoma(58;0.0749)					ATCTAGCGATCGCACGTTTTA	0.413		NaN											0	0	0	0.00308	0	7	60									
CELSR1	9620	broad.mit.edu	37	22	46930167	46930167	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr22:46930167C>A	uc003bhw.1	-	1	2901	c.2901G>T	c.(2899-2901)TGG>TGT	p.W967C		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	967	Extracellular (Potential).|Cadherin 7.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CAGCCAGAGCCCAAAGGTTGT	0.597		NaN											1	0	5.26018e-13	0.012319	5.66616e-13	20	19									
CNTN6	27255	broad.mit.edu	37	3	1367574	1367574	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:1367574C>G	uc003boz.2	+	9	1289	c.1022C>G	c.(1021-1023)GCT>GGT	p.A341G	CNTN6_uc011asj.1_Missense_Mutation_p.A269G|CNTN6_uc003bpa.2_Missense_Mutation_p.A341G	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	341	Ig-like C2-type 4.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		GAATGTAAAGCTAGTGGAAAG	0.398		NaN											0	0	0	0.006122	0	19	78									
CNTN6	27255	broad.mit.edu	37	3	1414637	1414637	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:1414637G>C	uc003boz.2	+	14	2051	c.1784G>C	c.(1783-1785)AGA>ACA	p.R595T	CNTN6_uc011asj.1_Missense_Mutation_p.R523T|CNTN6_uc003bpa.2_Missense_Mutation_p.R595T	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	595					axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		ATCATTGTTAGAGGTAAGCAT	0.353		NaN											0	0	0	0.001984	0	7	97									
LRRN1	57633	broad.mit.edu	37	3	3887485	3887485	+	Missense_Mutation	SNP	C	C	T	rs145675446	by1000genomes	TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:3887485C>T	uc003bpt.3	+	2	1921	c.1160C>T	c.(1159-1161)ACC>ATC	p.T387I	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	387	LRRCT.|Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		TCCAACAAAACCAACATCCGC	0.493		NaN											0	0	0	0.007835	0	42	56									
BRPF1	7862	broad.mit.edu	37	3	9776368	9776368	+	Silent	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:9776368C>A	uc003bse.2	+	2	943	c.544C>A	c.(544-546)CGG>AGG	p.R182R	BRPF1_uc003bsf.2_Silent_p.R182R|BRPF1_uc003bsg.2_Silent_p.R182R|BRPF1_uc011ati.1_Silent_p.R182R	NM_004634	NP_004625	P55201	BRPF1_HUMAN	bromodomain and PHD finger-containing protein 1	182	Interaction with MYST3 and MYST4.				histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Medulloblastoma(99;0.227)					GGTGGTCTATCGGGAGCTGGA	0.557		NaN											1	0	1.80694e-10	0.009535	1.91745e-10	30	54									
IL17RE	132014	broad.mit.edu	37	3	9945786	9945786	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:9945786C>T	uc003btu.2	+	4	336	c.219C>T	c.(217-219)GTC>GTT	p.V73V	CIDEC_uc003bto.2_Intron|IL17RE_uc003btv.2_Silent_p.V73V|IL17RE_uc011atn.1_Intron|IL17RE_uc003btw.2_Silent_p.V73V|IL17RE_uc003btx.2_Intron|IL17RE_uc010hcq.2_Silent_p.V73V|IL17RE_uc003bty.2_RNA	NM_153483	NP_705616	Q8NFR9	I17RE_HUMAN	interleukin 17 receptor E isoform 1	73	Extracellular (Potential).					cytoplasm|extracellular region|integral to membrane	receptor activity			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(96;5.34e-64)		GTGTGCGAGTCTGGCACTGTT	0.532		NaN											0	0	0	0.01441	0	54	117									
FANCD2	2177	broad.mit.edu	37	3	10084780	10084780	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:10084780T>G	uc003buw.2	+	12	1013	c.935T>G	c.(934-936)TTG>TGG	p.L312W	FANCD2_uc003bux.1_Missense_Mutation_p.L312W|FANCD2_uc003buy.1_Missense_Mutation_p.L312W	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	312	Interaction with BRCA2.				DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		CATTGTGTTTTGCCATCACGG	0.428		NaN	D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.012319	0	21	63									
SLC6A1	6529	broad.mit.edu	37	3	11067485	11067485	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:11067485C>T	uc010hdq.2	+	9	1287	c.876C>T	c.(874-876)ATC>ATT	p.I292I		NM_003042	NP_003033	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter	292	Helical; Name=6; (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)|skin(1)	2		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	CAACCCAGATCTTCTTCTCAT	0.517		NaN											0	0	0	0.006214	0	8	136									
RBMS3	27303	broad.mit.edu	37	3	29628627	29628627	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:29628627C>G	uc003cel.2	+	4	560	c.330C>G	c.(328-330)GAC>GAG	p.D110E	RBMS3_uc003cek.2_Missense_Mutation_p.D110E|RBMS3_uc010hfq.2_Missense_Mutation_p.D110E|RBMS3_uc003cem.2_Missense_Mutation_p.D109E|RBMS3_uc010hfr.2_Missense_Mutation_p.D110E	NM_001003793	NP_001003793	Q6XE24	RBMS3_HUMAN	RNA binding motif, single stranded interacting	110	RRM 1.					cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)	1		Ovarian(412;0.0956)				TAGATTTTGACAGTCCTGCAG	0.403		NaN											0	0	0	0.000602	0	5	50									
C3orf39	84892	broad.mit.edu	37	3	43122498	43122498	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:43122498G>A	uc003cmq.1	-	2	567	c.426C>T	c.(424-426)TTC>TTT	p.F142F	C3orf39_uc003cmr.1_Silent_p.F142F	NM_032806	NP_116195	Q8NAT1	AGO61_HUMAN	glycosyltransferase precursor	142						extracellular region	transferase activity, transferring glycosyl groups			ovary(1)|skin(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0571)|Kidney(284;0.0718)		GCTTGGGCATGAAGCGCAGGG	0.617		NaN											0	0	0	0.013537	0	11	95									
ZDHHC3	51304	broad.mit.edu	37	3	45000761	45000761	+	Silent	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:45000761G>C	uc003cod.2	-	2	442	c.168C>G	c.(166-168)CTC>CTG	p.L56L	ZDHHC3_uc003cog.2_Silent_p.L56L|ZDHHC3_uc011bad.1_Silent_p.L56L	NM_016598	NP_057682	Q9NYG2	ZDHC3_HUMAN	zinc finger, DHHC-type containing 3 isoform 2	56	Helical; (Potential).					Golgi membrane|integral to membrane	zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00943)|KIRC - Kidney renal clear cell carcinoma(197;0.053)|Kidney(197;0.0665)		ACTCCGCATAGAGGACCAGAA	0.537		NaN											0	0	0	0.004482	0	9	100									
ZDHHC3	51304	broad.mit.edu	37	3	45000794	45000794	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:45000794G>A	uc003cod.2	-	2	409	c.135C>T	c.(133-135)ATC>ATT	p.I45I	ZDHHC3_uc003cog.2_Silent_p.I45I|ZDHHC3_uc011bad.1_Silent_p.I45I	NM_016598	NP_057682	Q9NYG2	ZDHC3_HUMAN	zinc finger, DHHC-type containing 3 isoform 2	45	Cytoplasmic (Potential).					Golgi membrane|integral to membrane	zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00943)|KIRC - Kidney renal clear cell carcinoma(197;0.053)|Kidney(197;0.0665)		TGGCACAGGCGATGCCACAGC	0.537		NaN											0	0	0	0.003163	0	14	105									
CCR3	1232	broad.mit.edu	37	3	46306895	46306895	+	Silent	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:46306895C>G	uc003cpg.1	+	4	789	c.246C>G	c.(244-246)CTC>CTG	p.L82L	CCR3_uc003cpi.1_Silent_p.L82L|CCR3_uc003cpj.1_Silent_p.L82L|CCR3_uc003cpk.1_Silent_p.L103L|CCR3_uc010hjb.1_Silent_p.L100L|CCR3_uc003cpl.1_Silent_p.L115L	NM_178329	NP_847899	P51677	CCR3_HUMAN	CC chemokine receptor 3 isoform 1	82	Helical; Name=2; (Potential).				cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				ovary(3)|lung(3)|breast(1)|kidney(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		CGGACCTGCTCTTCCTCGTCA	0.498		NaN											0	0	0	0.013537	0	12	208									
USP4	7375	broad.mit.edu	37	3	49331930	49331930	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:49331930G>A	uc003cwq.2	-	14	1872	c.1793C>T	c.(1792-1794)TCA>TTA	p.S598L	USP4_uc003cwo.2_Missense_Mutation_p.S310L|USP4_uc003cwp.2_Missense_Mutation_p.S328L|USP4_uc003cwr.2_Missense_Mutation_p.S551L	NM_003363	NP_003354	Q13107	UBP4_HUMAN	ubiquitin specific protease 4 isoform a	598					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		ATATAGCGCTGATGCGGAGGA	0.527		NaN											0	0	0	0.004482	0	8	80									
ACTR8	93973	broad.mit.edu	37	3	53902769	53902769	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:53902769C>G	uc003dhd.2	-	13	1911	c.1852G>C	c.(1852-1854)GAG>CAG	p.E618Q	ACTR8_uc003dhb.2_Missense_Mutation_p.E323Q|ACTR8_uc003dhc.2_Missense_Mutation_p.E507Q	NM_022899	NP_075050	Q9H981	ARP8_HUMAN	actin-related protein 8	618					cell division|DNA recombination|DNA repair|mitosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex	protein binding			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000143)|KIRC - Kidney renal clear cell carcinoma(284;0.00544)|Kidney(284;0.00607)|OV - Ovarian serous cystadenocarcinoma(275;0.111)		GCAGCCCGCTCTCGTAACATG	0.478		NaN											0	0	0	0.004482	0	9	44									
DNASE1L3	1776	broad.mit.edu	37	3	58183687	58183687	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:58183687C>A	uc003djo.1	-	6	662	c.565G>T	c.(565-567)GAC>TAC	p.D189Y	DNASE1L3_uc011bfd.1_Missense_Mutation_p.D159Y|DNASE1L3_uc003djp.1_Missense_Mutation_p.D189Y|DNASE1L3_uc003djq.1_Missense_Mutation_p.D189Y	NM_004944	NP_004935	Q13609	DNSL3_HUMAN	deoxyribonuclease I-like 3 precursor	189					apoptosis|DNA catabolic process	nucleus	calcium ion binding|DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters			breast(2)|large_intestine(1)	3				BRCA - Breast invasive adenocarcinoma(55;0.00021)|KIRC - Kidney renal clear cell carcinoma(284;0.0445)|Kidney(284;0.0556)|OV - Ovarian serous cystadenocarcinoma(275;0.202)		GCATTGAAGTCACCCATGAAA	0.512		NaN											1	0	2.32078e-09	0.003163	2.4546e-09	14	30									
KCTD6	200845	broad.mit.edu	37	3	58486802	58486802	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:58486802C>T	uc003dkj.3	+	3	274	c.157C>T	c.(157-159)CAA>TAA	p.Q53*	KCTD6_uc003dki.3_Nonsense_Mutation_p.Q53*|KCTD6_uc003dkk.3_Nonsense_Mutation_p.Q53*	NM_001128214	NP_001121686	Q8NC69	KCTD6_HUMAN	potassium channel tetramerisation domain	53	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000177)|Kidney(10;0.00229)|KIRC - Kidney renal clear cell carcinoma(10;0.00258)|OV - Ovarian serous cystadenocarcinoma(275;0.148)		TCGAGACCCTCAAGGCAATTA	0.453		NaN											0	0	0	0.005524	0	40	77									
NFKBIZ	64332	broad.mit.edu	37	3	101572646	101572646	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:101572646G>C	uc003dvp.2	+	5	1391	c.1276G>C	c.(1276-1278)GAA>CAA	p.E426Q	NFKBIZ_uc003dvo.2_Missense_Mutation_p.E326Q|NFKBIZ_uc010hpo.2_Missense_Mutation_p.E326Q|NFKBIZ_uc003dvq.2_Missense_Mutation_p.E304Q	NM_031419	NP_113607	Q9BYH8	IKBZ_HUMAN	nuclear factor of kappa light polypeptide gene	426	Interaction with NFKB1/p50 (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(2)	2						GGAGCAGGAAGAAAGCAAATT	0.403		NaN											0	0	0	0.013726	0	34	46									
PHLDB2	90102	broad.mit.edu	37	3	111603414	111603414	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:111603414C>G	uc010hqa.2	+	2	901	c.490C>G	c.(490-492)CTT>GTT	p.L164V	PHLDB2_uc003dyc.2_Missense_Mutation_p.L191V|PHLDB2_uc003dyd.2_Missense_Mutation_p.L164V|PHLDB2_uc003dyg.2_Missense_Mutation_p.L164V|PHLDB2_uc003dyh.2_Missense_Mutation_p.L164V|PHLDB2_uc003dye.3_Missense_Mutation_p.L164V|PHLDB2_uc003dyf.3_Missense_Mutation_p.L164V	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	164						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						TGTCTACTCTCTTGGAGGGCT	0.542		NaN											0	0	0	0.014323	0	24	95									
PHLDB2	90102	broad.mit.edu	37	3	111603734	111603734	+	Silent	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:111603734C>G	uc010hqa.2	+	2	1221	c.810C>G	c.(808-810)CTC>CTG	p.L270L	PHLDB2_uc003dyc.2_Silent_p.L297L|PHLDB2_uc003dyd.2_Silent_p.L270L|PHLDB2_uc003dyg.2_Silent_p.L270L|PHLDB2_uc003dyh.2_Silent_p.L270L|PHLDB2_uc003dye.3_Silent_p.L270L|PHLDB2_uc003dyf.3_Silent_p.L270L	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	270						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						TGACACCTCTCAGCTTGCCTC	0.478		NaN											0	0	0	0.001855	0	13	53									
GAP43	2596	broad.mit.edu	37	3	115395213	115395213	+	Silent	SNP	T	T	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:115395213T>C	uc003ebq.2	+	2	770	c.384T>C	c.(382-384)CCT>CCC	p.P128P	GAP43_uc003ebr.2_Silent_p.P164P	NM_002045	NP_002036	P17677	NEUM_HUMAN	growth associated protein 43 isoform 2	128					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.164)		CCCAGGCTCCTGCATCCTCAG	0.602		NaN											0	0	0	0.00278	0	21	35									
ALDH1L1	10840	broad.mit.edu	37	3	125828793	125828793	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:125828793G>A	uc003eim.1	-	20	2531	c.2341C>T	c.(2341-2343)CGG>TGG	p.R781W	ALDH1L1_uc010hse.1_RNA|ALDH1L1_uc011bki.1_Missense_Mutation_p.R680W|ALDH1L1_uc003ein.1_Missense_Mutation_p.R316W	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	781	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	TCACCTGGCCGAGGGACCTGA	0.597		NaN											0	0	0	0.010729	0	11	30									
TMCC1	23023	broad.mit.edu	37	3	129546893	129546893	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:129546893C>T	uc003emz.3	-	4	830	c.329G>A	c.(328-330)CGA>CAA	p.R110Q	TMCC1_uc010htg.2_5'UTR	NM_001017395	NP_001017395	O94876	TMCC1_HUMAN	transmembrane and coiled-coil domain family 1	110						integral to membrane				skin(1)	1						GGGTGGCACTCGAATCTGCTG	0.552		NaN											0	0	0	0.013726	0	31	67									
COL6A6	131873	broad.mit.edu	37	3	130290033	130290033	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:130290033G>A	uc010htl.2	+	6	2804	c.2773G>A	c.(2773-2775)GAT>AAT	p.D925N		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	925	VWFA 5.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						GGAATCCCATGATGCTGATAA	0.567		NaN											0	0	0	0.001855	0	13	65									
C3orf36	80111	broad.mit.edu	37	3	133647541	133647541	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:133647541G>C	uc003epz.1	-	1	1116	c.107C>G	c.(106-108)TCT>TGT	p.S36C		NM_025041	NP_079317	Q3SXR2	CC036_HUMAN	hypothetical protein LOC80111	36										ovary(1)	1						TGAGGGGGCAGAGAGACACGT	0.587		NaN											0	0	0	0.010729	0	12	50									
ZBTB38	253461	broad.mit.edu	37	3	141163197	141163197	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:141163197G>T	uc003etw.2	+	8	2949	c.1967G>T	c.(1966-1968)GGA>GTA	p.G656V	ZBTB38_uc010hun.2_Missense_Mutation_p.G653V|ZBTB38_uc010huo.2_Missense_Mutation_p.G656V|ZBTB38_uc003ety.2_Missense_Mutation_p.G656V|ZBTB38_uc010hup.2_Missense_Mutation_p.G657V	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	656					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						ACCAAATGGGGAGAGGAGGCA	0.468		NaN											1	0	1.00905e-13	0.008871	1.08875e-13	20	119									
HPS3	84343	broad.mit.edu	37	3	148868438	148868438	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:148868438G>A	uc003ewu.1	+	6	1356	c.1216G>A	c.(1216-1218)GAG>AAG	p.E406K	HPS3_uc003ewt.1_Missense_Mutation_p.E406K|HPS3_uc011bnq.1_Missense_Mutation_p.E241K	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	406						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			AGCTCGTGAGGAGGACCCGTA	0.512		NaN							Hermansky-Pudlak_syndrome				0	0	0	0.008291	0	11	59									
TRIM59	286827	broad.mit.edu	37	3	160156793	160156793	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:160156793C>T	uc003fdm.2	-	3	374	c.179G>A	c.(178-180)AGA>AAA	p.R60K	IFT80_uc003fda.2_RNA	NM_173084	NP_775107	Q8IWR1	TRI59_HUMAN	tripartite motif-containing 59	60	RING-type.					integral to membrane|intracellular	zinc ion binding				0			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			AGTAATACTTCTGCAATTAGG	0.358		NaN											0	0	0	0.008871	0	20	89									
ATP11B	23200	broad.mit.edu	37	3	182577088	182577088	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:182577088G>A	uc003flb.2	+	12	1398	c.1141G>A	c.(1141-1143)GAA>AAA	p.E381K		NM_014616	NP_055431	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	381	Cytoplasmic (Potential).				aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			TCTGTATCATGAAGAATCAGA	0.328		NaN											0	0	0	0.004007	0	16	22									
HTR3E	285242	broad.mit.edu	37	3	183824447	183824447	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:183824447C>G	uc010hxq.2	+	9	1803	c.1337C>G	c.(1336-1338)TCT>TGT	p.S446C	HTR3E_uc003fml.3_Missense_Mutation_p.S431C|HTR3E_uc003fmm.2_Missense_Mutation_p.S461C|HTR3E_uc010hxr.2_Missense_Mutation_p.S472C|HTR3E_uc003fmn.2_Missense_Mutation_p.S446C	NM_182589	NP_872395	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine receptor 3 subunit E	446	Helical; Name=4; (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			ATGGCCTCCTCTATCATCACC	0.592		NaN											0	0	0	0.010818	0	32	83									
LPP	4026	broad.mit.edu	37	3	188327169	188327169	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:188327169C>T	uc003frs.1	+	6	896	c.650C>T	c.(649-651)TCA>TTA	p.S217L	LPP_uc011bsg.1_Missense_Mutation_p.S217L|LPP_uc011bsi.1_Missense_Mutation_p.S217L|LPP_uc003frt.2_Missense_Mutation_p.S217L|LPP_uc011bsj.1_Missense_Mutation_p.S54L	NM_005578	NP_005569	Q93052	LPP_HUMAN	LIM domain containing preferred translocation	217	Pro-rich.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	soft_tissue(134)|bone(27)|lung(2)|ovary(1)|breast(1)	165	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		TCCACTTCTTCAAGGCCTACC	0.592		NaN	T	HMGA2|MLL|C12orf9	lipoma|leukemia								0	0	0	0.010729	0	12	91									
GP5	2814	broad.mit.edu	37	3	194117344	194117344	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr3:194117344C>T	uc003ftv.1	-	2	1699	c.1668G>A	c.(1666-1668)GAG>GAA	p.E556E		NM_004488	NP_004479	P40197	GPV_HUMAN	glycoprotein V (platelet) precursor	556	Cytoplasmic (Potential).				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane				skin(2)|breast(1)	3	all_cancers(143;6.64e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;7.38e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.06e-05)		CAAGGGCTCTCTCTCTGATTA	0.413		NaN											0	0	0	0.006999	0	38	186									
CPLX1	10815	broad.mit.edu	37	4	780459	780459	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:780459C>T	uc003gbi.2	-	4	426	c.235G>A	c.(235-237)GAG>AAG	p.E79K	CPLX1_uc003gbj.2_Missense_Mutation_p.E58K	NM_006651	NP_006642	O14810	CPLX1_HUMAN	complexin 1	79					glutamate secretion	cytosol					0				Colorectal(103;0.187)		GCCTCGGCCTCGCGCTCCTCC	0.756		NaN											0	0	0	0.001855	0	13	13									
TMEM175	84286	broad.mit.edu	37	4	947001	947001	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:947001C>A	uc003gbq.2	+	8	584	c.486C>A	c.(484-486)TTC>TTA	p.F162L	TMEM175_uc010ibl.1_Missense_Mutation_p.F162L|TMEM175_uc003gbp.1_Missense_Mutation_p.F80L|TMEM175_uc003gbr.2_Missense_Mutation_p.F80L|TMEM175_uc003gbu.2_Missense_Mutation_p.F80L|TMEM175_uc003gbs.2_Missense_Mutation_p.F45L|TMEM175_uc003gbt.2_Missense_Mutation_p.F45L|TMEM175_uc003gbv.2_Missense_Mutation_p.F45L|TMEM175_uc010ibm.2_Intron	NM_032326	NP_115702	Q9BSA9	TM175_HUMAN	transmembrane protein 175	162						integral to membrane					0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GGTACGCATTCCACTTCCCGC	0.657		NaN											1	0	0.00909568	0.009096	0.00918149	4	25									
EVC	2121	broad.mit.edu	37	4	5749989	5749989	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:5749989G>T	uc003gil.1	+	8	1238	c.1054G>T	c.(1054-1056)GCA>TCA	p.A352S	EVC_uc003gim.1_RNA|CRMP1_uc003gin.1_Missense_Mutation_p.Q472K	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	352					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)				AAGAATGATTGCAGCCGAAGG	0.488		NaN											1	0	1.42536e-11	0.004656	1.52768e-11	25	11									
DRD5	1816	broad.mit.edu	37	4	9783854	9783854	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:9783854G>A	uc003gmb.3	+	1	597	c.201G>A	c.(199-201)CGG>CGA	p.R67R		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	67	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CCATCGTGCGGAGCCGCCACC	0.647		NaN											0	0	0	0.008291	0	10	8									
DRD5	1816	broad.mit.edu	37	4	9783920	9783920	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:9783920C>T	uc003gmb.3	+	1	663	c.267C>T	c.(265-267)TTC>TTT	p.F89F		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	89	Helical; Name=2; (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CAGACCTTTTCGTGGCGCTGC	0.632		NaN											0	0	0	0.008871	0	19	17									
LDB2	9079	broad.mit.edu	37	4	16590352	16590352	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:16590352C>G	uc003goz.2	-	4	828	c.512G>C	c.(511-513)AGA>ACA	p.R171T	LDB2_uc003gpa.2_Missense_Mutation_p.R171T|LDB2_uc003gpb.2_Missense_Mutation_p.R171T|LDB2_uc011bxh.1_Missense_Mutation_p.R171T|LDB2_uc010iee.2_Missense_Mutation_p.R171T|LDB2_uc003goy.2_Missense_Mutation_p.R47T|LDB2_uc011bxi.1_Missense_Mutation_p.R47T	NM_001290	NP_001281	O43679	LDB2_HUMAN	LIM domain binding 2 isoform a	171							LIM domain binding|transcription cofactor activity				0						TAGGATGCTTCTCGGGACTAA	0.393		NaN											0	0	0	0.001168	0	6	62									
ATP10D	57205	broad.mit.edu	37	4	47583998	47583998	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:47583998G>A	uc003gxk.1	+	21	3834	c.3670G>A	c.(3670-3672)GAC>AAC	p.D1224N	ATP10D_uc003gxl.1_Missense_Mutation_p.D472N	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	1224	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						CTCAGATACTGACATCTTTGC	0.448		NaN											0	0	0	0.004878	0	37	99									
UGT2B4	7363	broad.mit.edu	37	4	70359471	70359471	+	Silent	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:70359471G>C	uc003hek.3	-	2	857	c.810C>G	c.(808-810)CTC>CTG	p.L270L	UGT2B4_uc011cap.1_Silent_p.L134L|UGT2B4_uc003hel.3_Silent_p.L270L	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	270					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						CATTTGGTAAGAGTGGGTGAG	0.433		NaN											0	0	0	0.006214	0	8	146									
ODAM	54959	broad.mit.edu	37	4	71063726	71063726	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:71063726C>G	uc003hfc.2	+	4	244	c.227C>G	c.(226-228)TCT>TGT	p.S76C		NM_017855	NP_060325	A1E959	ODAM_HUMAN	odontogenic ameloblast-associated protein	76	Gln-rich.				biomineral tissue development|odontogenesis of dentine-containing tooth	fibril				ovary(3)|large_intestine(1)	4						TCCCAGTTCTCTTTATCAGCT	0.478		NaN											0	0	0	0.00623	0	40	144									
NPFFR2	10886	broad.mit.edu	37	4	72994488	72994488	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:72994488G>T	uc003hgg.2	+	2	584	c.486G>T	c.(484-486)ATG>ATT	p.M162I	NPFFR2_uc010iig.1_Intron|NPFFR2_uc003hgi.2_Missense_Mutation_p.M63I|NPFFR2_uc003hgh.2_Missense_Mutation_p.M60I	NM_004885	NP_004876	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2 isoform 1	162	Helical; Name=1; (Potential).				detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			TTTTGTGCATGATGGGAAATA	0.358		NaN											1	0	3.5997e-14	0.014323	3.89058e-14	22	136									
ALB	213	broad.mit.edu	37	4	74284010	74284010	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:74284010G>A	uc003hgs.3	+	12	1707	c.1634G>A	c.(1633-1635)AGA>AAA	p.R545K	ALB_uc003hgw.3_Missense_Mutation_p.R353K|ALB_uc011cbe.1_Missense_Mutation_p.R224K|ALB_uc003hgt.3_Missense_Mutation_p.R545K|ALB_uc010iii.2_Missense_Mutation_p.R430K|ALB_uc003hgu.3_Missense_Mutation_p.R395K|ALB_uc003hgv.3_Missense_Mutation_p.R224K|ALB_uc011cbf.1_Missense_Mutation_p.R435K|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_Missense_Mutation_p.R224K	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	545	Albumin 3.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	GAGAAGGAGAGACAAATCAAG	0.383		NaN											0	0	0	0.007413	0	20	39									
AGPAT9	84803	broad.mit.edu	37	4	84457852	84457852	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:84457852C>T	uc003how.2	+	2	295	c.77C>T	c.(76-78)TCG>TTG	p.S26L	AGPAT9_uc003hox.2_Missense_Mutation_p.S26L|AGPAT9_uc003hoy.2_Missense_Mutation_p.S26L	NM_032717	NP_116106	Q53EU6	GPAT3_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 9	26	Helical; (Potential).				phospholipid biosynthetic process|regulation of TOR signaling cascade|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	glycerol-3-phosphate O-acyltransferase activity			skin(1)	1		Hepatocellular(203;0.114)				CTTTTACCTTCGGTCTTCGGA	0.582		NaN											0	0	0	0.001168	0	5	24									
HSD17B13	345275	broad.mit.edu	37	4	88238288	88238288	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:88238288C>T	uc003hqo.2	-	3	469	c.406G>A	c.(406-408)GAG>AAG	p.E136K	HSD17B13_uc010ikk.2_Missense_Mutation_p.E100K	NM_178135	NP_835236	Q7Z5P4	DHB13_HUMAN	hydroxysteroid (17-beta) dehydrogenase 13	136						extracellular region	binding|oxidoreductase activity				0		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.000308)		TTGGTAATCTCTTCATCCTTG	0.403		NaN											0	0	0	0.004289	0	39	57									
EIF4E	1977	broad.mit.edu	37	4	99802262	99802262	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:99802262G>C	uc003hue.2	-	7	2094	c.571C>G	c.(571-573)CCA>GCA	p.P191A	EIF4E_uc011cea.1_Missense_Mutation_p.P211A|EIF4E_uc011ceb.1_Missense_Mutation_p.P222A	NM_001968	NP_001959	P06730	IF4E_HUMAN	eukaryotic translation initiation factor 4E	191					G1/S transition of mitotic cell cycle|insulin receptor signaling pathway|interspecies interaction between organisms|mRNA export from nucleus|nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of mitotic cell cycle|regulation of translation	cytoplasmic mRNA processing body|cytosol|eukaryotic translation initiation factor 4F complex|mRNA cap binding complex|RNA-induced silencing complex	protein binding|RNA cap binding|translation initiation factor activity			lung(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)|LUSC - Lung squamous cell carcinoma(721;0.00227)		ACTATCTTTGGAGGAAGTCCT	0.363		NaN											0	0	0	0.008291	0	9	37									
ANK2	287	broad.mit.edu	37	4	114276668	114276668	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:114276668G>A	uc003ibe.3	+	38	6994	c.6894G>A	c.(6892-6894)GAG>GAA	p.E2298E	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Silent_p.E2313E	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2265					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CAGTCACTGAGGACTCAGAGA	0.488		NaN											0	0	0	0.008291	0	11	30									
NUDT6	11162	broad.mit.edu	37	4	123843692	123843692	+	Silent	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:123843692C>G	uc003iew.2	-	1	68	c.36G>C	c.(34-36)GCG>GCC	p.A12A	SPATA5_uc003iey.2_5'Flank|SPATA5_uc003iez.3_5'Flank|NUDT6_uc003iex.2_Intron	NM_007083	NP_009014	P53370	NUDT6_HUMAN	nudix-type motif 6 isoform a	12						mitochondrion|nucleus	growth factor activity|hydrolase activity				0						GGGCAAGCATCGCGCGCCAGC	0.692		NaN											0	0	0	0.001984	0	7	20									
TIGD4	201798	broad.mit.edu	37	4	153691640	153691640	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:153691640C>A	uc003imy.2	-	2	1299	c.517G>T	c.(517-519)GAT>TAT	p.D173Y		NM_145720	NP_663772	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	173					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			ovary(1)	1	all_hematologic(180;0.093)					GGATGATAATCATTTAAATAA	0.353		NaN											1	0	8.88839e-20	0.010818	9.72121e-20	34	72									
TIGD4	201798	broad.mit.edu	37	4	153691892	153691892	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:153691892C>A	uc003imy.2	-	2	1047	c.265G>T	c.(265-267)GAG>TAG	p.E89*		NM_145720	NP_663772	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	89	HTH CENPB-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			ovary(1)	1	all_hematologic(180;0.093)					ATTAATGCCTCTTCCAGATCT	0.363		NaN											1	0	4.37618e-36	0.01441	4.80258e-36	53	122									
TIGD4	201798	broad.mit.edu	37	4	153691920	153691920	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:153691920C>T	uc003imy.2	-	2	1019	c.237G>A	c.(235-237)CTG>CTA	p.L79L		NM_145720	NP_663772	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	79	HTH CENPB-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			ovary(1)	1	all_hematologic(180;0.093)					AAGCAGTTCTCAGTCTTTTTC	0.338		NaN											0	0	0	0.007835	0	44	102									
LRAT	9227	broad.mit.edu	37	4	155665889	155665889	+	Silent	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:155665889C>G	uc003iom.1	+	1	738	c.411C>G	c.(409-411)CTC>CTG	p.L137L	uc003iol.2_Intron|LRAT_uc003ion.1_Silent_p.L137L	NM_004744	NP_004735	O95237	LRAT_HUMAN	lecithin retinol acyltransferase	137	Cytoplasmic (By similarity).				response to stimulus|retinoid metabolic process|steroid metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|multivesicular body|perinuclear region of cytoplasm|rough endoplasmic reticulum	phosphatidylcholine-retinol O-acyltransferase activity			central_nervous_system(1)	1	all_hematologic(180;0.215)	Renal(120;0.0458)			Vitamin A(DB00162)	AGGCACTGCTCAACGAGGAGG	0.577		NaN											0	0	0	0.012319	0	21	32									
ODZ3	55714	broad.mit.edu	37	4	183267846	183267846	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:183267846C>A	uc003ivd.1	+	2	312	c.275C>A	c.(274-276)GCA>GAA	p.A92E	ODZ3_uc010irv.1_Missense_Mutation_p.A92E	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	92	Cytoplasmic (Potential).|Teneurin N-terminal.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		TGTGAACCAGCAACTCGAAGA	0.428		NaN											1	0	5.03518e-11	0.007413	5.38765e-11	17	17									
PDLIM3	27295	broad.mit.edu	37	4	186423477	186423477	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:186423477C>T	uc003ixw.3	-	8	1190	c.1066G>A	c.(1066-1068)GAC>AAC	p.D356N	PDLIM3_uc003ixx.3_Missense_Mutation_p.D308N|PDLIM3_uc010isi.2_RNA	NM_014476	NP_055291	Q53GG5	PDLI3_HUMAN	PDZ and LIM domain protein 3 isoform a	356						sarcomere	zinc ion binding			ovary(2)	2		all_lung(41;1.03e-13)|Lung NSC(41;2.49e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.00996)|Colorectal(36;0.0161)|all_hematologic(60;0.0592)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.4e-10)|BRCA - Breast invasive adenocarcinoma(30;8.64e-05)|GBM - Glioblastoma multiforme(59;0.000167)|STAD - Stomach adenocarcinoma(60;0.000828)|LUSC - Lung squamous cell carcinoma(40;0.00984)|COAD - Colon adenocarcinoma(29;0.0115)|READ - Rectum adenocarcinoma(43;0.171)		GTGACCGTGTCATAGCCCTCT	0.428		NaN											0	0	0	0.011902	0	45	86									
ADAMTS16	170690	broad.mit.edu	37	5	5237174	5237174	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:5237174G>A	uc003jdl.2	+	14	2254	c.2116G>A	c.(2116-2118)GAG>AAG	p.E706K	ADAMTS16_uc003jdk.1_Missense_Mutation_p.E706K|ADAMTS16_uc010itk.1_Intron	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	706	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						TCCATGCTCGGAGGATAGCCG	0.284		NaN											0	0	0	0.003954	0	23	93									
PAPD7	11044	broad.mit.edu	37	5	6750570	6750570	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:6750570C>T	uc003jdx.1	+	10	1193	c.1064C>T	c.(1063-1065)TCA>TTA	p.S355L	PAPD7_uc011cmn.1_Missense_Mutation_p.S346L|PAPD7_uc010itl.1_Missense_Mutation_p.S175L	NM_006999	NP_008930	Q5XG87	PAPD7_HUMAN	DNA polymerase sigma	355	Ser-rich.				cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			ovary(1)	1						CTCCTGTCTTCAGGCTCCTCG	0.572		NaN											0	0	0	0.008291	0	11	54									
DNAH5	1767	broad.mit.edu	37	5	13919382	13919382	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:13919382C>G	uc003jfd.2	-	7	920	c.878G>C	c.(877-879)AGA>ACA	p.R293T	DNAH5_uc003jfe.1_RNA	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	293	Potential.|Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CTTGGAGAGTCTTTTTTTCCA	0.517		NaN							Kartagener_syndrome				0	0	0	0.009535	0	31	202									
CARD6	84674	broad.mit.edu	37	5	40852632	40852632	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:40852632C>T	uc003jmg.2	+	3	1273	c.1198C>T	c.(1198-1200)CAG>TAG	p.Q400*		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	400					apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						AAACATGTATCAGTGCCAGTT	0.453		NaN											0	0	0	0.014323	0	23	47									
IL31RA	133396	broad.mit.edu	37	5	55178994	55178994	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:55178994C>T	uc003jql.2	+	5	642	c.577C>T	c.(577-579)CGA>TGA	p.R193*	IL31RA_uc003jqk.2_Nonsense_Mutation_p.R193*|IL31RA_uc011cqj.1_Nonsense_Mutation_p.R51*|IL31RA_uc003jqm.2_Nonsense_Mutation_p.R161*|IL31RA_uc003jqn.2_Nonsense_Mutation_p.R193*|IL31RA_uc010iwa.1_Nonsense_Mutation_p.R161*|IL31RA_uc003jqo.2_Nonsense_Mutation_p.R51*	NM_139017	NP_620586	Q8NI17	IL31R_HUMAN	gp130-like monocyte receptor	161	Extracellular (Potential).|Fibronectin type-III 2.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			ovary(1)	1		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				ATACACACTTCGATTCAGGAC	0.383		NaN											0	0	0	0.001855	0	14	31									
MAST4	375449	broad.mit.edu	37	5	66386048	66386048	+	Silent	SNP	A	A	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:66386048A>G	uc003jut.1	+	5	323	c.255A>G	c.(253-255)TCA>TCG	p.S85S	MAST4_uc003jus.2_Silent_p.S85S|MAST4_uc003juu.1_Silent_p.S92S|MAST4_uc011cra.1_Silent_p.S65S|MAST4_uc010ixa.2_RNA|MAST4_uc003juv.2_Silent_p.S80S|MAST4_uc003juw.2_Silent_p.S80S	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	274						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		CCCATTTTTCATTTGCACGGA	0.328		NaN											0	0	0	0.010729	0	9	7									
TNPO1	3842	broad.mit.edu	37	5	72192888	72192888	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:72192888G>C	uc003kck.3	+	20	2395	c.2248G>C	c.(2248-2250)GAG>CAG	p.E750Q	TNPO1_uc011csj.1_Missense_Mutation_p.E700Q|TNPO1_uc003kch.2_Missense_Mutation_p.E742Q|TNPO1_uc003kci.3_Missense_Mutation_p.E742Q|TNPO1_uc003kcg.3_Missense_Mutation_p.E742Q	NM_002270	NP_002261	Q92973	TNPO1_HUMAN	transportin 1 isoform 1	750					interspecies interaction between organisms|mRNA metabolic process|protein import into nucleus, translocation	cytosol|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			skin(3)|urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)	7		Lung NSC(167;0.0053)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;6.14e-54)		TCTAGGTATAGAGATGCAGCC	0.343		NaN											0	0	0	0.00499	0	16	31									
CAST	831	broad.mit.edu	37	5	96086315	96086315	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:96086315C>T	uc003klz.1	+	18	1366	c.1204C>T	c.(1204-1206)CCT>TCT	p.P402S	CAST_uc003klt.2_Missense_Mutation_p.P389S|CAST_uc003klu.2_Missense_Mutation_p.P485S|CAST_uc003klv.2_Missense_Mutation_p.P463S|CAST_uc003klw.2_Missense_Mutation_p.P466S|CAST_uc003klx.2_Missense_Mutation_p.P444S|CAST_uc003kly.2_Missense_Mutation_p.P450S|CAST_uc011cuo.1_Missense_Mutation_p.P448S|CAST_uc011cuq.1_Missense_Mutation_p.P250S|CAST_uc011cur.1_Missense_Mutation_p.P388S|CAST_uc011cus.1_Missense_Mutation_p.P389S|CAST_uc003kma.1_Missense_Mutation_p.P361S|CAST_uc011cut.1_Missense_Mutation_p.P330S|CAST_uc003kmb.2_Missense_Mutation_p.P348S|CAST_uc003kmc.2_Missense_Mutation_p.P402S|CAST_uc003kmd.2_Missense_Mutation_p.P380S|CAST_uc003kme.2_Missense_Mutation_p.P361S|CAST_uc003kmf.2_Missense_Mutation_p.P367S|CAST_uc003kmh.2_Missense_Mutation_p.P117S|CAST_uc010jbj.2_Missense_Mutation_p.P117S|CAST_uc010jbk.2_Missense_Mutation_p.P117S|CAST_uc010jbl.1_Missense_Mutation_p.P125S|CAST_uc003kmi.2_RNA|CAST_uc003kmj.2_Missense_Mutation_p.P125S	NM_001042443	NP_001035908	P20810	ICAL_HUMAN	calpastatin isoform i	402							calcium-dependent cysteine-type endopeptidase inhibitor activity|protein binding			central_nervous_system(3)|ovary(1)|kidney(1)	5		all_cancers(142;5.27e-07)|all_epithelial(76;8.21e-10)|all_lung(232;0.000396)|Lung NSC(167;0.000539)|Ovarian(225;0.024)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;6.85e-15)		TGCTCCAGCTCCTGTGTCGGA	0.488		NaN											0	0	0	0.008291	0	10	29									
APC	324	broad.mit.edu	37	5	112103071	112103071	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:112103071G>T	uc010jby.2	+	4	786	c.406G>T	c.(406-408)GAA>TAA	p.E136*	APC_uc011cvt.1_Nonsense_Mutation_p.E146*|APC_uc003kpz.3_Nonsense_Mutation_p.E136*|APC_uc003kpy.3_Nonsense_Mutation_p.E136*|APC_uc010jbz.2_5'UTR	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	136	Leu-rich.|Potential.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity			large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		ATATTTAGAAGAACTTGAGAA	0.338		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			1	0	2.75727e-19	0.004878	3.01049e-19	35	16									
TSSK1B	83942	broad.mit.edu	37	5	112770257	112770257	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:112770257C>T	uc003kqm.2	-	1	472	c.280G>A	c.(280-282)GTC>ATC	p.V94I	MCC_uc003kql.3_Intron	NM_032028	NP_114417	Q9BXA7	TSSK1_HUMAN	testis-specific serine kinase 1	94	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|skin(2)|stomach(1)	5		all_cancers(142;0.0138)|all_epithelial(76;0.000445)|Colorectal(10;0.00814)|Prostate(80;0.0115)|Ovarian(225;0.156)		Epithelial(69;4.15e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.49e-08)|all cancers(49;3.2e-06)|COAD - Colon adenocarcinoma(37;0.0371)|Colorectal(14;0.0449)		TCGCCCTGGACCGCGAGCTCC	0.512		NaN											0	0	0	0.010729	0	11	24									
CEP120	153241	broad.mit.edu	37	5	122717855	122717855	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:122717855C>T	uc003ktk.2	-	15	2135	c.2053G>A	c.(2053-2055)GAG>AAG	p.E685K	CEP120_uc011cwq.1_Missense_Mutation_p.E494K|CEP120_uc010jcz.1_Missense_Mutation_p.E659K	NM_153223	NP_694955	Q8N960	CE120_HUMAN	coiled-coil domain containing 100	685	Potential.					centrosome				ovary(1)	1						TTCCATTCCTCTGCAAGAGCC	0.353		NaN											0	0	0	0.001168	0	5	65									
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139917811	139917811	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:139917811C>T	uc003lfs.1	+	32	7493	c.7369C>T	c.(7369-7371)CAG>TAG	p.Q2457*	ANKHD1_uc003lfr.2_Nonsense_Mutation_p.Q2457*|ANKHD1-EIF4EBP3_uc011czh.1_Nonsense_Mutation_p.Q1213*|ANKHD1_uc003lfw.2_Nonsense_Mutation_p.Q1112*|ANKHD1_uc010jfl.2_Nonsense_Mutation_p.Q833*|ANKHD1-EIF4EBP3_uc003lfx.1_Nonsense_Mutation_p.Q611*	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	2457						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATTTTTCATCAGCCTATGGC	0.408		NaN											0	0	0	0.009718	0	39	120									
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139918544	139918544	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:139918544C>G	uc003lfs.1	+	33	7569	c.7445C>G	c.(7444-7446)TCT>TGT	p.S2482C	ANKHD1_uc003lfr.2_Missense_Mutation_p.S2482C|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.S1238C|ANKHD1_uc003lfw.2_Missense_Mutation_p.S1137C|ANKHD1_uc010jfl.2_Missense_Mutation_p.S858C|ANKHD1-EIF4EBP3_uc003lfx.1_Missense_Mutation_p.S627C	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	2482						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATAATACCCTCTCATCCTCAG	0.348		NaN											0	0	0	0.004007	0	14	29									
PCDHA1	56147	broad.mit.edu	37	5	140166145	140166145	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:140166145C>T	uc003lhb.2	+	1	270	c.270C>T	c.(268-270)ATC>ATT	p.I90I	PCDHA1_uc003lha.2_Silent_p.I90I|PCDHA1_uc003lgz.2_Silent_p.I90I	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	90	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTCTCGGATCGATCGCGAGG	0.577		NaN											0	0	0	0.001168	0	6	104									
PCDHA8	56140	broad.mit.edu	37	5	140222414	140222414	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:140222414C>T	uc003lhs.2	+	1	1508	c.1508C>T	c.(1507-1509)TCG>TTG	p.S503L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.S503L	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	503	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGAGCGCTCGCTGTCGAGC	0.667		NaN											0	0	0	0.009718	0	39	30									
ADRB2	154	broad.mit.edu	37	5	148207582	148207582	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:148207582C>A	uc003lpr.1	+	1	1427	c.1188C>A	c.(1186-1188)AGC>AGA	p.S396R	SH3TC2_uc003lpp.1_Intron	NM_000024	NP_000015	P07550	ADRB2_HUMAN	adrenergic, beta-2-, receptor, surface	396	Cytoplasmic.				activation of transmembrane receptor protein tyrosine kinase activity|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|endosome to lysosome transport|positive regulation of MAPKKK cascade|receptor-mediated endocytosis	endosome|integral to plasma membrane|lysosome|receptor complex	beta2-adrenergic receptor activity|norepinephrine binding|potassium channel regulator activity|protein homodimerization activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Alprenolol(DB00866)|Arformoterol(DB01274)|Bambuterol(DB01408)|Bisoprolol(DB00612)|Bitolterol(DB00901)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Clenbuterol(DB01407)|Desipramine(DB01151)|Epinephrine(DB00668)|Fenoterol(DB01288)|Formoterol(DB00983)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Nadolol(DB01203)|Norepinephrine(DB00368)|Orciprenaline(DB00816)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Pirbuterol(DB01291)|Procaterol(DB01366)|Propranolol(DB00571)|Pseudoephedrine(DB00852)|Ritodrine(DB00867)|Salbutamol(DB01001)|Salmeterol(DB00938)|Terbutaline(DB00871)|Timolol(DB00373)	CTGTGCCTAGCGATAACATTG	0.453		NaN											1	0	6.44725e-10	0.014323	6.83026e-10	22	21									
GABRP	2568	broad.mit.edu	37	5	170239053	170239053	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:170239053G>A	uc003mau.2	+	10	1312	c.1114G>A	c.(1114-1116)GAA>AAA	p.E372K	GABRP_uc011dev.1_3'UTR	NM_014211	NP_055026	O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	372	Cytoplasmic (Potential).					cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGCCAGCATTGAAATTTCCAG	0.413		NaN											0	0	0	0.008871	0	20	72									
UIMC1	51720	broad.mit.edu	37	5	176409576	176409576	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:176409576G>A	uc011dfp.1	-	2	208	c.41C>T	c.(40-42)TCT>TTT	p.S14F	UIMC1_uc003mfc.1_5'UTR|UIMC1_uc003mfd.1_5'UTR|UIMC1_uc003mfg.1_Missense_Mutation_p.S14F|UIMC1_uc003mfh.1_Missense_Mutation_p.S14F|UIMC1_uc010jkj.1_Missense_Mutation_p.S14F|UIMC1_uc011dfq.1_Missense_Mutation_p.S14F	NM_016290	NP_057374	Q96RL1	UIMC1_HUMAN	ubiquitin interaction motif containing 1	14	Necessary for transcriptional repression.				double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|negative regulation of transcription, DNA-dependent|positive regulation of DNA repair|response to ionizing radiation|transcription, DNA-dependent	BRCA1-A complex	histone binding|K63-linked polyubiquitin binding			ovary(3)|skin(1)	4	all_cancers(89;7.96e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	Medulloblastoma(196;0.0145)|all_neural(177;0.0325)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAGGTTCCGAGATTCGGAGAC	0.373		NaN											0	0	0	0.008291	0	11	67									
BTNL8	79908	broad.mit.edu	37	5	180326337	180326337	+	Silent	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:180326337G>C	uc003mmp.2	+	1	261	c.27G>C	c.(25-27)CTG>CTC	p.L9L	BTNL8_uc003mmq.2_Silent_p.L9L|BTNL8_uc011dhg.1_5'UTR|BTNL8_uc010jll.2_Silent_p.L9L|BTNL8_uc010jlm.2_Silent_p.L9L	NM_001040462	NP_001035552	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8 isoform 2 precursor	9						integral to membrane				upper_aerodigestive_tract(1)|skin(1)	2	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTTTGGTTCTGAGTCTCCTCA	0.453		NaN											0	0	0	0.00874	0	40	180									
TFAP2A	7020	broad.mit.edu	37	6	10404933	10404933	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:10404933G>A	uc003myr.2	-	4	824	c.572C>T	c.(571-573)TCC>TTC	p.S191F	TFAP2A_uc003myq.2_Missense_Mutation_p.S185F|TFAP2A_uc003mys.2_RNA|TFAP2A_uc011dih.1_Missense_Mutation_p.S191F|TFAP2A_uc003myt.2_Missense_Mutation_p.S187F|TFAP2A_uc003myu.1_Missense_Mutation_p.S191F	NM_003220	NP_003211	P05549	AP2A_HUMAN	transcription factor AP-2 alpha isoform a	191					ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)	1	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				AGGGATGGCGGAGACGGCATT	0.627		NaN											0	0	0	0.003271	0	34	43									
JARID2	3720	broad.mit.edu	37	6	15468887	15468887	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:15468887C>T	uc003nbj.2	+	5	852	c.608C>T	c.(607-609)TCA>TTA	p.S203L	JARID2_uc011diu.1_Missense_Mutation_p.S67L|JARID2_uc011div.1_Missense_Mutation_p.S31L|JARID2_uc011diw.1_Missense_Mutation_p.S165L	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	203					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AACAATGCTTCATCTTCATGC	0.468		NaN											0	0	0	0.00499	0	16	51									
ALDH5A1	7915	broad.mit.edu	37	6	24528378	24528378	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:24528378C>T	uc003neg.2	+	8	1355	c.1327C>T	c.(1327-1329)CTG>TTG	p.L443L	ALDH5A1_uc003nef.2_Silent_p.L456L	NM_001080	NP_001071	P51649	SSDH_HUMAN	aldehyde dehydrogenase 5A1 isoform 2 precursor	443					acetate metabolic process|central nervous system development|galactosylceramide metabolic process|gamma-aminobutyric acid catabolic process|glucose metabolic process|glutamate metabolic process|glutamine metabolic process|glutathione metabolic process|glycerophospholipid metabolic process|neurotransmitter catabolic process|neurotransmitter secretion|protein homotetramerization|respiratory electron transport chain|short-chain fatty acid metabolic process|succinate metabolic process	mitochondrial matrix|soluble fraction	succinate-semialdehyde dehydrogenase activity				0					Chlormerodrin(DB00534)|NADH(DB00157)|Succinic acid(DB00139)	TTTCGGGCCTCTGGCACCAGT	0.488		NaN											0	0	0	0.014323	0	22	29									
HIST1H2BE	8344	broad.mit.edu	37	6	26184092	26184092	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:26184092G>A	uc003ngt.2	+	1	69	c.69G>A	c.(67-69)CAG>CAA	p.Q23Q		NM_003523	NP_003514	P62807	H2B1C_HUMAN	histone cluster 1, H2be	23					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0						CCAAGGCGCAGAAGAAGGACG	0.577		NaN											0	0	0	0.01441	0	59	114									
ZNF193	7746	broad.mit.edu	37	6	28200360	28200360	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:28200360G>A	uc003nkq.1	+	4	704	c.589G>A	c.(589-591)GAC>AAC	p.D197N	ZNF193_uc003nkr.1_Missense_Mutation_p.D197N|ZNF193_uc010jqz.1_Missense_Mutation_p.D248N	NM_006299	NP_006290	O15535	ZN193_HUMAN	zinc finger protein 193	197					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CAAGACTGAGGACAGAGAGTT	0.423		NaN											0	0	0	0.001984	0	6	77									
TRIM27	5987	broad.mit.edu	37	6	28872256	28872256	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:28872256C>T	uc003nlr.2	-	8	1492	c.1133G>A	c.(1132-1134)GGA>GAA	p.G378E	TRIM27_uc003nls.2_Intron|TRIM27_uc003nlt.1_3'UTR	NM_006510	NP_006501	P14373	TRI27_HUMAN	ret finger protein	378	B30.2/SPRY.				cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			ovary(1)	1						GGCTTTATCTCCCACCTCTAC	0.532		NaN	T	RET	papillary thyroid								0	0	0	0.003163	0	16	75									
ZBTB22	9278	broad.mit.edu	37	6	33284067	33284067	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:33284067G>A	uc003oeb.2	-	2	779	c.627C>T	c.(625-627)TTC>TTT	p.F209F	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Silent_p.F209F	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	209					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CCCTGGGGCTGAAGTAGTTGC	0.617		NaN											0	0	0	0.010504	0	22	35									
RNF8	9025	broad.mit.edu	37	6	37336788	37336788	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:37336788C>T	uc003onq.3	+	3	962	c.769C>T	c.(769-771)CTG>TTG	p.L257L	RNF8_uc003onr.3_Silent_p.L257L|RNF8_uc011dtx.1_Silent_p.L189L	NM_003958	NP_003949	O76064	RNF8_HUMAN	ring finger protein 8 isoform 1	257					cell division|double-strand break repair|histone H2A ubiquitination|histone H2B ubiquitination|mitosis|positive regulation of DNA repair|response to ionizing radiation	midbody|nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1						GTCCAGGATTCTGAGGCTCAA	0.433		NaN											0	0	0	0.010504	0	20	90									
TRERF1	55809	broad.mit.edu	37	6	42196160	42196160	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:42196160C>T	uc003osd.2	-	18	4089	c.3526G>A	c.(3526-3528)GAG>AAG	p.E1176K	TRERF1_uc011duq.1_Missense_Mutation_p.E1093K|TRERF1_uc003osb.2_Missense_Mutation_p.E944K|TRERF1_uc003osc.2_Missense_Mutation_p.E932K|TRERF1_uc003ose.2_Missense_Mutation_p.E1196K	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	1176	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			ACTTCAGCCTCTTCCATGACA	0.532		NaN											0	0	0	0.010729	0	12	148									
XPO5	57510	broad.mit.edu	37	6	43521164	43521164	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:43521164C>T	uc003ovp.2	-	14	1729	c.1518G>A	c.(1516-1518)ATG>ATA	p.M506I		NM_020750	NP_065801	Q9HAV4	XPO5_HUMAN	exportin 5	506					gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			skin(2)|breast(1)|kidney(1)	4	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			AAAAAAGAGTCATGGCTTCCC	0.368		NaN											0	0	0	0.004672	0	3	12									
XPO5	57510	broad.mit.edu	37	6	43528732	43528732	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:43528732C>G	uc003ovp.2	-	10	1235	c.1024G>C	c.(1024-1026)GAT>CAT	p.D342H		NM_020750	NP_065801	Q9HAV4	XPO5_HUMAN	exportin 5	342					gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			skin(2)|breast(1)|kidney(1)	4	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			GTTTCTACATCAGAATCTGCA	0.368		NaN											0	0	0	0.00245	0	14	67									
POLH	5429	broad.mit.edu	37	6	43555015	43555015	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:43555015G>A	uc003ovq.3	+	4	583	c.279G>A	c.(277-279)CGG>CGA	p.R93R	POLH_uc010jyu.2_Intron|POLH_uc011dvl.1_RNA|POLH_uc003ovr.3_5'UTR	NM_006502	NP_006493	Q9Y253	POLH_HUMAN	DNA-directed DNA polymerase eta	93	UmuC.				DNA replication|DNA synthesis involved in DNA repair|regulation of DNA repair|response to UV-C	cytoplasm|nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			breast(2)	2	all_cancers(18;1.89e-05)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000753)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			TTAGGTACCGGGAAGCCAGTG	0.448		NaN						DNA_polymerases_(catalytic_subunits)	Xeroderma_Pigmentosum				0	0	0	0.001855	0	12	158									
POLH	5429	broad.mit.edu	37	6	43555211	43555211	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:43555211G>C	uc003ovq.3	+	4	779	c.475G>C	c.(475-477)GAG>CAG	p.E159Q	POLH_uc010jyu.2_Intron|POLH_uc011dvl.1_RNA|POLH_uc003ovr.3_Missense_Mutation_p.E60Q	NM_006502	NP_006493	Q9Y253	POLH_HUMAN	DNA-directed DNA polymerase eta	159	UmuC.				DNA replication|DNA synthesis involved in DNA repair|regulation of DNA repair|response to UV-C	cytoplasm|nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			breast(2)	2	all_cancers(18;1.89e-05)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000753)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			AACGGCAGAAGAGACTGTTCA	0.473		NaN						DNA_polymerases_(catalytic_subunits)	Xeroderma_Pigmentosum				0	0	0	0.000602	0	5	61									
SLC25A27	9481	broad.mit.edu	37	6	46644175	46644175	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:46644175G>A	uc003oyh.2	+	9	1207	c.956G>A	c.(955-957)GGA>GAA	p.G319E	SLC25A27_uc011dwb.1_Intron|SLC25A27_uc003oyg.2_Intron|SLC25A27_uc011dwc.1_Missense_Mutation_p.G233E|SLC25A27_uc003oyi.2_Missense_Mutation_p.G249E	NM_004277	NP_004268	O95847	UCP4_HUMAN	solute carrier family 25, member 27	319					generation of precursor metabolites and energy|transport	integral to membrane|mitochondrial inner membrane					0			Lung(136;0.192)			GAGATGAGTGGAGTCAGTCCA	0.368		NaN											0	0	0	0.00278	0	20	87									
CD2AP	23607	broad.mit.edu	37	6	47563717	47563717	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:47563717C>G	uc003oyw.2	+	12	1685	c.1229C>G	c.(1228-1230)CCA>CGA	p.P410R		NM_012120	NP_036252	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	410	SH3-binding (Potential).|Pro-rich.				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			ACAGTGTACCCAAAGCGACCT	0.423		NaN											0	0	0	0.009535	0	29	176									
PHF3	23469	broad.mit.edu	37	6	64395311	64395311	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:64395311C>A	uc003pep.1	+	3	1714	c.1688C>A	c.(1687-1689)TCT>TAT	p.S563Y	PHF3_uc010kaf.1_Missense_Mutation_p.S563Y|PHF3_uc003pem.2_Missense_Mutation_p.S516Y|PHF3_uc010kag.1_Missense_Mutation_p.S475Y|PHF3_uc010kah.1_Missense_Mutation_p.S377Y|PHF3_uc003pen.2_Missense_Mutation_p.S475Y|PHF3_uc011dxs.1_Intron|PHF3_uc003peo.2_Missense_Mutation_p.S563Y	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	563					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			AGTTGCAATTCTGGGGTTAAA	0.343		NaN											1	0	8.24728e-16	0.004656	8.95898e-16	26	39									
FAM46A	55603	broad.mit.edu	37	6	82459924	82459924	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:82459924C>G	uc003pjg.2	-	3	1135	c.817G>C	c.(817-819)GAT>CAT	p.D273H	FAM46A_uc003pjf.2_Missense_Mutation_p.D292H	NM_017633	NP_060103	Q96IP4	FA46A_HUMAN	hypothetical protein LOC55603	273											0		all_cancers(76;6.74e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000282)|all_epithelial(107;0.0104)		BRCA - Breast invasive adenocarcinoma(397;0.0428)		CAAAGGTGATCAAAGGCTTCC	0.493		NaN											0	0	0	0.003163	0	15	68									
MDN1	23195	broad.mit.edu	37	6	90420473	90420473	+	Silent	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:90420473G>C	uc003pnn.1	-	50	7808	c.7692C>G	c.(7690-7692)CTC>CTG	p.L2564L		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	2564					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AAAAATTCCTGAGAGATGCAG	0.348		NaN											0	0	0	0.003163	0	15	33									
CASP8AP2	9994	broad.mit.edu	37	6	90577477	90577477	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:90577477G>C	uc003pnr.2	+	8	4664	c.4468G>C	c.(4468-4470)GAG>CAG	p.E1490Q	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Missense_Mutation_p.E1490Q|CASP8AP2_uc011dzz.1_Missense_Mutation_p.E1490Q	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	1490					cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		GGATGCATCTGAGCAAGATAT	0.408		NaN											0	0	0	0.004289	0	34	52									
BVES	11149	broad.mit.edu	37	6	105577271	105577271	+	Silent	SNP	A	A	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:105577271A>G	uc003pqw.2	-	3	491	c.334T>C	c.(334-336)TTA>CTA	p.L112L	BVES_uc003pqx.2_Silent_p.L112L|BVES_uc003pqy.2_Silent_p.L112L	NM_147147	NP_671488	Q8NE79	POPD1_HUMAN	blood vessel epicardial substance isoform 5	112	Helical; (Potential).				epithelial cell-cell adhesion|muscle organ development|positive regulation of locomotion|positive regulation of receptor recycling|regulation of Cdc42 GTPase activity|regulation of cell shape|regulation of Rac GTPase activity|substrate adhesion-dependent cell spreading|vesicle-mediated transport	integral to membrane|lateral plasma membrane|tight junction	structural molecule activity				0		all_cancers(87;2.83e-05)|Acute lymphoblastic leukemia(125;1.95e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0101)|Colorectal(196;0.204)|Lung NSC(302;0.238)				TTCTTGTATAAAAGATACGAC	0.348		NaN											0	0	0	0.008871	0	21	45									
GJA1	2697	broad.mit.edu	37	6	121768780	121768780	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:121768780C>A	uc003pyr.2	+	2	1037	c.787C>A	c.(787-789)CAA>AAA	p.Q263K	GJA1_uc011ebo.1_Missense_Mutation_p.Q164K|GJA1_uc011ebp.1_Missense_Mutation_p.Q51K	NM_000165	NP_000156	P17302	CXA1_HUMAN	connexin 43	263	Cytoplasmic (Potential).				cell-cell signaling|cellular membrane organization|gap junction assembly|heart development|muscle contraction|positive regulation of I-kappaB kinase/NF-kappaB cascade	connexon complex|Golgi-associated vesicle membrane|integral to plasma membrane|membrane raft	ion transmembrane transporter activity|signal transducer activity			ovary(2)	2				GBM - Glioblastoma multiforme(226;0.00252)	Carvedilol(DB01136)	CTGTGGGTCTCAAAAATATGC	0.517		NaN											1	0	4.96729e-08	0.008871	5.19381e-08	21	87									
PTPRK	5796	broad.mit.edu	37	6	128411102	128411102	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:128411102C>T	uc003qbk.2	-	8	1565	c.1198G>A	c.(1198-1200)GAA>AAA	p.E400K	PTPRK_uc003qbj.2_Missense_Mutation_p.E400K|PTPRK_uc010kfc.2_Missense_Mutation_p.E400K|PTPRK_uc011ebu.1_Missense_Mutation_p.E400K|PTPRK_uc003qbl.1_Missense_Mutation_p.E270K|PTPRK_uc011ebv.1_Missense_Mutation_p.E400K	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	400	Extracellular (Potential).|Fibronectin type-III 2.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		GCCTGTATTTCAGCAATCTTT	0.383		NaN											0	0	0	0.00623	0	37	94									
L3MBTL3	84456	broad.mit.edu	37	6	130392177	130392177	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:130392177G>C	uc003qbt.2	+	13	1319	c.1149G>C	c.(1147-1149)AAG>AAC	p.K383N	L3MBTL3_uc003qbu.2_Missense_Mutation_p.K358N	NM_032438	NP_115814	Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 isoform a	383	MBT 2.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		TAGACAAAAAGAATCCCTCAT	0.423		NaN											0	0	0	0.01441	0	59	289									
BCLAF1	9774	broad.mit.edu	37	6	136582453	136582453	+	Missense_Mutation	SNP	C	C	T	rs141900019		TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:136582453C>T	uc003qgx.1	-	12	2960	c.2707G>A	c.(2707-2709)GAG>AAG	p.E903K	BCLAF1_uc011edb.1_Missense_Mutation_p.E182K|BCLAF1_uc003qgw.1_Missense_Mutation_p.E730K|BCLAF1_uc003qgy.1_Missense_Mutation_p.E852K|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.E901K	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	903					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TCCATGGTCTCTTCTTCATCT	0.373		NaN											0	0	0	0.004007	0	15	291									
BCLAF1	9774	broad.mit.edu	37	6	136589379	136589379	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:136589379C>T	uc003qgx.1	-	10	2571	c.2318G>A	c.(2317-2319)AGA>AAA	p.R773K	BCLAF1_uc011edb.1_Missense_Mutation_p.R101K|BCLAF1_uc003qgw.1_Missense_Mutation_p.R600K|BCLAF1_uc003qgy.1_Missense_Mutation_p.R771K|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.R771K	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	773					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TTCTTCTTCTCTTTCCTTCTT	0.383		NaN											0	0	0	0.007413	0	19	203									
KIAA1244	57221	broad.mit.edu	37	6	138619775	138619775	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:138619775G>A	uc003qhu.2	+	22	3681	c.3681G>A	c.(3679-3681)CAG>CAA	p.Q1227Q		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	1227					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		ATGTGTCTCAGAAGGCTGTTT	0.473		NaN											0	0	0	0.007291	0	28	25									
SHPRH	257218	broad.mit.edu	37	6	146242491	146242491	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:146242491C>T	uc003qlf.2	-	21	4219	c.3820G>A	c.(3820-3822)GAA>AAA	p.E1274K	SHPRH_uc003qld.2_Missense_Mutation_p.E1278K|SHPRH_uc003qle.2_Missense_Mutation_p.E1278K|SHPRH_uc003qlg.1_Missense_Mutation_p.E830K|SHPRH_uc003qlh.2_Missense_Mutation_p.E199K|SHPRH_uc003qli.1_Missense_Mutation_p.E199K	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	1274					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		TCTTCATCTTCTATCATCTCC	0.433		NaN											0	0	0	0.009096	0	4	25									
TULP4	56995	broad.mit.edu	37	6	158735144	158735144	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:158735144G>A	uc003qrf.2	+	1	1453	c.96G>A	c.(94-96)GAG>GAA	p.E32E	TULP4_uc011efo.1_Silent_p.E32E|TULP4_uc003qrg.2_Silent_p.E32E	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	32					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		GTGAGAAGGAGAAGCCTGTGT	0.572		NaN											0	0	0	0.001855	0	14	27									
C6orf70	55780	broad.mit.edu	37	6	170156863	170156863	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:170156863C>T	uc003qxg.1	+	5	499	c.466C>T	c.(466-468)CTT>TTT	p.L156F	C6orf70_uc011ehb.1_Missense_Mutation_p.L30F|C6orf70_uc003qxh.1_Missense_Mutation_p.L156F|C6orf70_uc010kky.1_Missense_Mutation_p.L30F	NM_018341	NP_060811	Q5T6L9	CF070_HUMAN	hypothetical protein LOC55780	156						integral to membrane				ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.2e-22)|BRCA - Breast invasive adenocarcinoma(81;1.49e-07)|GBM - Glioblastoma multiforme(31;0.00191)		AAGAGATCTGCTTTCATCTGA	0.308		NaN											0	0	0	0.003755	0	30	87									
CHST12	55501	broad.mit.edu	37	7	2473142	2473142	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:2473142G>A	uc003smc.2	+	2	1003	c.868G>A	c.(868-870)GAG>AAG	p.E290K	CHST12_uc003smd.2_Missense_Mutation_p.E290K	NM_018641	NP_061111	Q9NRB3	CHSTC_HUMAN	carbohydrate sulfotransferase 12	290	Lumenal (Potential).				dermatan sulfate biosynthetic process	integral to Golgi membrane	3'-phosphoadenosine 5'-phosphosulfate binding|chondroitin 4-sulfotransferase activity|protein binding			kidney(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0847)|OV - Ovarian serous cystadenocarcinoma(56;2.25e-13)		CTCGGCGCGCGAGGCCTTCCG	0.652		NaN											0	0	0	0.010729	0	11	99									
WIPF3	644150	broad.mit.edu	37	7	29915522	29915522	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:29915522G>A	uc003taj.1	+	2	167	c.167G>A	c.(166-168)GGA>GAA	p.G56E		NM_001080529	NP_001073998	A6NGB9	WIPF3_HUMAN	WAS/WASL interacting protein family, member 3	56										ovary(1)	1						ATCCAGCAAGGAACTCGCCTG	0.582		NaN											0	0	0	0.006214	0	9	58									
CCDC129	223075	broad.mit.edu	37	7	31682680	31682680	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:31682680C>G	uc003tcj.1	+	11	2689	c.1696C>G	c.(1696-1698)CTG>GTG	p.L566V	CCDC129_uc011kad.1_Missense_Mutation_p.L576V|CCDC129_uc003tci.1_Missense_Mutation_p.L417V|CCDC129_uc011kae.1_Missense_Mutation_p.L592V|CCDC129_uc003tck.1_Missense_Mutation_p.L474V	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	566											0						TGATCATCCTCTGGGGTTTAT	0.517		NaN											0	0	0	0.010729	0	12	223									
NT5C3	51251	broad.mit.edu	37	7	33063689	33063689	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:33063689C>G	uc003tdk.2	-	3	361	c.284G>C	c.(283-285)AGA>ACA	p.R95T	AVL9_uc011kai.1_Intron|NT5C3_uc003tdi.2_Missense_Mutation_p.R56T|NT5C3_uc003tdj.2_Missense_Mutation_p.R56T	NM_001002010	NP_001002010	Q9H0P0	5NT3_HUMAN	5'-nucleotidase, cytosolic III isoform 1	95				R -> K (in Ref. 11; AA sequence).	nucleotide metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol|endoplasmic reticulum	2'-phosphotransferase activity|5'-nucleotidase activity|magnesium ion binding|nucleotide binding			ovary(1)	1			GBM - Glioblastoma multiforme(11;0.0894)			ATATGAAAATCTACTGAGTGT	0.338		NaN											0	0	0	0.001168	0	5	19									
ABCA13	154664	broad.mit.edu	37	7	48313605	48313605	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:48313605C>G	uc003toq.2	+	17	4367	c.4342C>G	c.(4342-4344)CTT>GTT	p.L1448V	ABCA13_uc010kyr.2_Missense_Mutation_p.L951V	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	1448					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						AAAAAAACCTCTTTGTTCATC	0.264		NaN											0	0	0	0.010729	0	10	55									
ZNF479	90827	broad.mit.edu	37	7	57187752	57187752	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:57187752C>T	uc010kzo.2	-	5	1641	c.1370G>A	c.(1369-1371)AGA>AAA	p.R457K		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	457	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			AGTATGAATTCTCTTGTGGTC	0.433		NaN											0	0	0	0.00308	0	8	133									
ZNF479	90827	broad.mit.edu	37	7	57188486	57188487	+	Missense_Mutation	DNP	GG	GG	AA			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:57188486_57188487GG>AA	uc010kzo.2	-	5	906_907	c.635_636CC>TT	c.(634-636)TCC>TTT	p.S212F		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	212	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TGCATTTGTAGGACTTCTCCCT	0.332		NaN											0	0	0	0.004672	0	11	19									
CACNA2D1	781	broad.mit.edu	37	7	82072690	82072690	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:82072690G>A	uc003uhr.1	-	1	342	c.86C>T	c.(85-87)TCG>TTG	p.S29L		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	29	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CGTGACGGCCGAAGGGAACGG	0.488		NaN											0	0	0	0.001984	0	7	21									
ABCB1	5243	broad.mit.edu	37	7	87165842	87165842	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:87165842C>T	uc003uiz.1	-	21	2831	c.2413G>A	c.(2413-2415)GAT>AAT	p.D805N	ABCB1_uc011khc.1_Missense_Mutation_p.D741N	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	805	ABC transmembrane type-1 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TTAGGGTCATCAAACCAACTC	0.343		NaN											0	0	0	0.004482	0	6	56									
TMEM130	222865	broad.mit.edu	37	7	98446226	98446226	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:98446226G>C	uc003upo.2	-	7	1288	c.1099C>G	c.(1099-1101)CAG>GAG	p.Q367E	TMEM130_uc011kiq.1_Missense_Mutation_p.Q348E|TMEM130_uc011kir.1_Missense_Mutation_p.Q367E|TMEM130_uc003upn.2_Missense_Mutation_p.Q265E	NM_001134450	NP_001127922	Q8N3G9	TM130_HUMAN	transmembrane protein 130 isoform a	367	Cytoplasmic (Potential).					Golgi membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TCCTTTTGCTGAGTGGCATTC	0.552		NaN											0	0	0	0.008291	0	11	96									
TRRAP	8295	broad.mit.edu	37	7	98581089	98581089	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:98581089C>T	uc003upp.2	+	59	9217	c.9008C>T	c.(9007-9009)CCG>CTG	p.P3003L	TRRAP_uc011kis.1_Intron|TRRAP_uc003upr.2_Intron	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3003	FAT.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			cagggtaaaccgacctggtcc	0.259		NaN											0	0	0	0.012319	0	22	20									
CYP3A5	1577	broad.mit.edu	37	7	99247765	99247765	+	Silent	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:99247765G>C	uc003urq.2	-	12	1431	c.1344C>G	c.(1342-1344)CTC>CTG	p.L448L	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urp.2_Silent_p.L268L|CYP3A5_uc003urr.2_Silent_p.L335L|CYP3A5_uc011kiy.1_Silent_p.L438L|CYP3A5_uc003urs.2_Silent_p.L96L|CYP3A5_uc010lgg.2_Silent_p.L54L	NM_000777	NP_000768	P20815	CP3A5_HUMAN	cytochrome P450, family 3, subfamily A,	448					alkaloid catabolic process|drug catabolic process|oxidative demethylation|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0	all_epithelial(64;2.77e-08)|Lung NSC(181;0.00396)|all_lung(186;0.00659)|Esophageal squamous(72;0.0166)				Alfentanil(DB00802)|Clopidogrel(DB00758)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Indinavir(DB00224)|Irinotecan(DB00762)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Mephenytoin(DB00532)|Midazolam(DB00683)|Mifepristone(DB00834)|Phenytoin(DB00252)|Quinine(DB00468)|Saquinavir(DB01232)|Tacrolimus(DB00864)|Troleandomycin(DB01361)|Verapamil(DB00661)|Vincristine(DB00541)	TCATGTTCATGAGAGCAAACC	0.398		NaN											0	0	0	0.004482	0	9	170									
ZAN	7455	broad.mit.edu	37	7	100395059	100395059	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:100395059G>C	uc003uwj.2	+	47	8503	c.8338G>C	c.(8338-8340)GAG>CAG	p.E2780Q	ZAN_uc003uwk.2_Missense_Mutation_p.E2689Q|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kke.1_Missense_Mutation_p.E729Q	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	2780	VWFC 5.|Cytoplasmic (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CGTGACCAGAGAGTGCATTTA	0.602		NaN											0	0	0	0.005443	0	24	39									
VGF	7425	broad.mit.edu	37	7	100806828	100806828	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:100806828C>T	uc003uxx.3	-	2	1515	c.1297G>A	c.(1297-1299)GAG>AAG	p.E433K		NM_003378	NP_003369	O15240	VGF_HUMAN	VGF nerve growth factor inducible precursor	433	Asp/Glu-rich (acidic).				response to cAMP	extracellular space|transport vesicle	growth factor activity				0	Lung NSC(181;0.168)|all_lung(186;0.215)					tctgtcccctcggcctccttc	0.493		NaN											0	0	0	0.004672	0	3	15									
LRWD1	222229	broad.mit.edu	37	7	102106340	102106340	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:102106340G>A	uc003uzn.2	+	2	295	c.157G>A	c.(157-159)GAC>AAC	p.D53N	ALKBH4_uc003uzl.2_5'Flank|ALKBH4_uc003uzm.2_5'Flank|LRWD1_uc003uzo.2_5'UTR	NM_152892	NP_690852	Q9UFC0	LRWD1_HUMAN	leucine-rich repeats and WD repeat domain	53	LRR 2.				chromatin modification|DNA-dependent DNA replication initiation|establishment of protein localization to chromatin|G1 phase of mitotic cell cycle	centromeric heterochromatin|nuclear origin of replication recognition complex|telomeric heterochromatin	chromatin binding|methyl-CpG binding|methylated histone residue binding			skin(1)	1						GCAGGAGCTTGACCTGTCTAA	0.622		NaN											0	0	0	0.00333	0	24	42									
RELN	5649	broad.mit.edu	37	7	103207108	103207108	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:103207108C>T	uc003vca.2	-	32	4847	c.4687G>A	c.(4687-4689)GAC>AAC	p.D1563N	RELN_uc010liz.2_Missense_Mutation_p.D1563N	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1563					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TGTGGCAGGTCAATGGAAATG	0.478		NaN											0	0	0	0.010818	0	33	73									
COG5	10466	broad.mit.edu	37	7	106924162	106924162	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:106924162C>G	uc003ved.2	-	13	1947	c.1422G>C	c.(1420-1422)TTG>TTC	p.L474F	COG5_uc003vec.2_Missense_Mutation_p.L474F|COG5_uc003vee.2_Missense_Mutation_p.L474F	NM_181733	NP_859422	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5 isoform	474					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			central_nervous_system(2)|skin(2)	4						GTGAGTCTTTCAAAGCCTTTT	0.368		NaN											0	0	0	0.012319	0	20	104									
PPP1R3A	5506	broad.mit.edu	37	7	113518227	113518227	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:113518227C>T	uc010ljy.1	-	4	2951	c.2920G>A	c.(2920-2922)GAA>AAA	p.E974K		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	974					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						GAAACTTCTTCAGGTTTAGAC	0.378		NaN											0	0	0	0.009718	0	45	76									
TFEC	22797	broad.mit.edu	37	7	115624399	115624399	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:115624399G>C	uc003vhj.1	-	2	281	c.97C>G	c.(97-99)CTG>GTG	p.L33V	TFEC_uc003vhk.1_Missense_Mutation_p.L33V|TFEC_uc003vhl.3_Missense_Mutation_p.L33V|TFEC_uc011kmw.1_Missense_Mutation_p.L123V	NM_012252	NP_036384	O14948	TFEC_HUMAN	transcription factor EC isoform a	33	Necessary for transcriptional transactivation.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			large_intestine(1)	1			STAD - Stomach adenocarcinoma(10;0.00878)			TCACTGTCCAGAGTTGTGTGT	0.468		NaN											0	0	0	0.009535	0	32	148									
MET	4233	broad.mit.edu	37	7	116380132	116380132	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:116380132G>A	uc003vij.2	+	4	1708	c.1521G>A	c.(1519-1521)GGG>GGA	p.G507G	MET_uc010lkh.2_Silent_p.G507G|MET_uc011knc.1_Silent_p.G507G|MET_uc011knd.1_Silent_p.G507G|MET_uc011kne.1_Silent_p.G507G|MET_uc011knf.1_Silent_p.G507G|MET_uc011kng.1_Silent_p.G507G|MET_uc011knh.1_Silent_p.G507G|MET_uc011kni.1_Silent_p.G507G|MET_uc011knj.1_Silent_p.G77G|MET_uc011kna.1_Silent_p.G507G|MET_uc011knb.1_Silent_p.G507G	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	507	Extracellular (Potential).|Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			TTATCACTGGGAAGAAGGTAA	0.438		NaN	Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				0	0	0	0.001984	0	7	135									
GRM8	2918	broad.mit.edu	37	7	126542614	126542614	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:126542614G>A	uc003vlr.2	-	5	1449	c.1138C>T	c.(1138-1140)CAT>TAT	p.H380Y	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.H380Y|GRM8_uc010lkz.1_RNA|GRM8_uc003vlu.1_Missense_Mutation_p.H101Y	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	380	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	TTCTTTATATGACTGTTCCTT	0.353		NaN								HNSCC(24;0.065)			0	0	0	0.00308	0	6	64									
TNPO3	23534	broad.mit.edu	37	7	128610354	128610354	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:128610354C>T	uc003vol.1	-	20	2820	c.2446G>A	c.(2446-2448)GAA>AAA	p.E816K	TNPO3_uc010llx.1_Missense_Mutation_p.E227K|TNPO3_uc003vom.1_Missense_Mutation_p.E750K|TNPO3_uc010lly.1_Missense_Mutation_p.E850K|TNPO3_uc010llz.1_Missense_Mutation_p.E752K	NM_012470	NP_036602	Q9Y5L0	TNPO3_HUMAN	transportin 3	816					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			ovary(2)|skin(2)|lung(1)	5						TTCCGTAATTCAAAGTCTTCT	0.458		NaN											0	0	0	0.013726	0	34	183									
CLEC5A	23601	broad.mit.edu	37	7	141645174	141645174	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:141645174C>T	uc003vwv.1	-	3	303	c.106G>A	c.(106-108)GAT>AAT	p.D36N	CLEC5A_uc011krm.1_Missense_Mutation_p.D36N|CLEC5A_uc003vww.1_Missense_Mutation_p.D36N|CLEC5A_uc010lnq.1_Missense_Mutation_p.D36N|CLEC5A_uc010lnr.1_RNA	NM_013252	NP_037384	Q9NY25	CLC5A_HUMAN	C-type lectin, superfamily member 5	36	Extracellular (Potential).				anti-apoptosis|cellular defense response|innate immune response|interspecies interaction between organisms|osteoblast development	cell surface|integral to plasma membrane	sugar binding|viral receptor activity				0	Melanoma(164;0.0171)					GTGAAACCATCGTTACTTTTG	0.438		NaN											0	0	0	0.003954	0	27	54									
TRPV6	55503	broad.mit.edu	37	7	142569636	142569636	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:142569636C>T	uc003wbx.1	-	15	2218	c.2002G>A	c.(2002-2004)GAG>AAG	p.E668K	TRPV6_uc003wbw.1_Missense_Mutation_p.E454K|TRPV6_uc010lou.1_Missense_Mutation_p.E539K	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	668	Cytoplasmic (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					CAGCCCAGCTCTAGTTTTTCC	0.582		NaN											0	0	0	0.00499	0	17	57									
CNTNAP2	26047	broad.mit.edu	37	7	147869504	147869504	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:147869504G>C	uc003weu.1	+	18	3460	c.2944G>C	c.(2944-2946)GAG>CAG	p.E982Q		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	982	EGF-like 2.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CAAATGCCTAGAGAGATACCA	0.473		NaN								HNSCC(39;0.1)			0	0	0	0.00333	0	26	119									
ZNF777	27153	broad.mit.edu	37	7	149129350	149129350	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:149129350C>T	uc003wfv.2	-	6	2176	c.2013G>A	c.(2011-2013)AAG>AAA	p.K671K		NM_015694	NP_056509	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	671	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			GGCGGAAGCTCTTCTTGCACT	0.622		NaN											0	0	0	0.007291	0	30	133									
CRYGN	155051	broad.mit.edu	37	7	151135092	151135092	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:151135092G>T	uc003wke.2	-	2	356	c.260C>A	c.(259-261)CCT>CAT	p.P87H	CRYGN_uc003wkf.2_Missense_Mutation_p.P87H|CRYGN_uc003wkg.2_RNA|CRYGN_uc010lqd.1_5'Flank	NM_144727	NP_653328	Q8WXF5	CRGN_HUMAN	gammaN-crystallin	87	Beta/gamma crystallin 'Greek key' 2.										0			OV - Ovarian serous cystadenocarcinoma(82;0.00358)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CATTCCTACAGGCCGACAGGA	0.642		NaN											1	0	3.45872e-05	0.004007	3.5642e-05	16	52									
MLL3	58508	broad.mit.edu	37	7	151860518	151860518	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:151860518G>A	uc003wla.2	-	43	10363	c.10144C>T	c.(10144-10146)CGG>TGG	p.R3382W	MLL3_uc003wkz.2_Missense_Mutation_p.R2443W|MLL3_uc003wky.2_Missense_Mutation_p.R891W	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	3382	Gln-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		AATTCTACCCGAGGTGGTGGT	0.458		NaN	N		medulloblastoma								0	0	0	0.01441	0	63	108									
PTPRN2	5799	broad.mit.edu	37	7	158282442	158282442	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr7:158282442C>T	uc003wno.2	-	2	269	c.148G>A	c.(148-150)GAG>AAG	p.E50K	PTPRN2_uc003wnp.2_Intron|PTPRN2_uc003wnq.2_Missense_Mutation_p.E50K|PTPRN2_uc003wnr.2_Missense_Mutation_p.E50K|PTPRN2_uc011kwa.1_Missense_Mutation_p.E73K	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	50	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		ACACAGGCCTCGGACGCTCCG	0.731		NaN											0	0	0	0.009096	0	4	5									
CSMD1	64478	broad.mit.edu	37	8	2832056	2832056	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:2832056C>G	uc011kwk.1	-	56	9050	c.8660G>C	c.(8659-8661)AGA>ACA	p.R2887T	CSMD1_uc011kwj.1_Missense_Mutation_p.R2216T|CSMD1_uc010lrg.2_Missense_Mutation_p.R897T	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2887	Sushi 21.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CTCGCTCCCTCTGCAGGAGTA	0.597		NaN											0	0	0	0.010729	0	12	16									
NEIL2	252969	broad.mit.edu	37	8	11637344	11637344	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:11637344G>C	uc003wug.2	+	3	1051	c.376G>C	c.(376-378)GAT>CAT	p.D126H	NEIL2_uc003wue.2_Missense_Mutation_p.D126H|NEIL2_uc003wuf.2_Missense_Mutation_p.D65H|NEIL2_uc011kxd.1_Intron	NM_145043	NP_659480	Q969S2	NEIL2_HUMAN	nei like 2 isoform a	126					base-excision repair|nucleotide-excision repair	nucleus	damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|hydrolase activity, hydrolyzing N-glycosyl compounds|zinc ion binding				0	all_epithelial(15;0.103)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.166)		CCCTGCAGGAGATGCTGGGAG	0.577		NaN						BER_DNA_glycosylases					0	0	0	0.003163	0	16	83									
PCM1	5108	broad.mit.edu	37	8	17813070	17813070	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:17813070C>T	uc003wyi.3	+	10	1802	c.1380C>T	c.(1378-1380)AGC>AGT	p.S460S	PCM1_uc011kyh.1_Silent_p.S460S|PCM1_uc003wyj.3_Silent_p.S460S|PCM1_uc003wyh.2_Silent_p.S499S|PCM1_uc010lta.1_Silent_p.S499S	NM_006197	NP_006188	Q15154	PCM1_HUMAN	pericentriolar material 1	460					centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	haematopoietic_and_lymphoid_tissue(30)|breast(4)|ovary(2)	36				Colorectal(111;0.0789)		AATCCAATAGCCTCACATCAT	0.458		NaN	T	RET|JAK2	papillary thyroid|CML|MPD								0	0	0	0.00308	0	7	23									
ADAM18	8749	broad.mit.edu	37	8	39537620	39537620	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:39537620C>T	uc003xni.2	+	16	1696	c.1696C>T	c.(1696-1698)CAA>TAA	p.Q566*	ADAM18_uc010lww.2_RNA|ADAM18_uc010lwx.2_Nonsense_Mutation_p.Q542*	NM_014237	NP_055052	Q9Y3Q7	ADA18_HUMAN	a disintegrin and metalloprotease domain 18	566	Cys-rich.|Extracellular (Potential).				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)|kidney(1)|skin(1)	6		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			AAGTGACGCTCAATCTACAGT	0.383		NaN											0	0	0	0.001984	0	7	91									
MYST3	7994	broad.mit.edu	37	8	41906305	41906305	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:41906305G>C	uc010lxb.2	-	3	735	c.191C>G	c.(190-192)TCA>TGA	p.S64*	MYST3_uc010lxc.2_Nonsense_Mutation_p.S64*|MYST3_uc003xon.3_Nonsense_Mutation_p.S64*|MYST3_uc010lxd.2_Nonsense_Mutation_p.S64*	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	64	Required for activation of RUNX1-1.|Required for nuclear localization.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			TCCTTTATTTGAGACTTTTAA	0.368		NaN											0	0	0	0.005443	0	28	206									
DKK4	27121	broad.mit.edu	37	8	42232338	42232338	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:42232338G>A	uc003xpb.2	-	3	467	c.356C>T	c.(355-357)CCA>CTA	p.P119L		NM_014420	NP_055235	Q9UBT3	DKK4_HUMAN	dickkopf homolog 4 precursor	119					multicellular organismal development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular region				ovary(1)	1	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;2.58e-12)|Lung NSC(13;4.24e-11)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.1)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;3.48e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00523)|Lung(22;0.00597)|LUSC - Lung squamous cell carcinoma(45;0.024)			TTCCTGGACTGGGTGCCCAGT	0.443		NaN											0	0	0	0.01441	0	71	222									
ARFGEF1	10565	broad.mit.edu	37	8	68211501	68211501	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:68211501T>C	uc003xxo.1	-	4	792	c.402A>G	c.(400-402)ATA>ATG	p.I134M		NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	134					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			AGCAGCCACATATTGTTTCAA	0.328		NaN											0	0	0	0.00308	0	8	15									
ZFHX4	79776	broad.mit.edu	37	8	77766229	77766229	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:77766229C>T	uc003yav.2	+	10	7324	c.6937C>T	c.(6937-6939)CAA>TAA	p.Q2313*	ZFHX4_uc003yau.1_Nonsense_Mutation_p.Q2358*|ZFHX4_uc003yaw.1_Nonsense_Mutation_p.Q2313*	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2313						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TGCCACTGATCAAGTGGTATA	0.493		NaN								HNSCC(33;0.089)			0	0	0	0.009535	0	29	136									
DCAF4L2	138009	broad.mit.edu	37	8	88885613	88885613	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:88885613G>A	uc003ydz.2	-	1	684	c.587C>T	c.(586-588)GCG>GTG	p.A196V		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	196										ovary(1)	1						AGAGTGATACGCGTGGATGCT	0.557		NaN											0	0	0	0.007835	0	42	77									
KIAA1429	25962	broad.mit.edu	37	8	95556077	95556077	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:95556077G>A	uc003ygo.1	-	2	170	c.157C>T	c.(157-159)CTG>TTG	p.L53L	KIAA1429_uc003ygp.2_Silent_p.L53L	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	53					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TTGTCTGGCAGACTGCTATGG	0.358		NaN											0	0	0	0.00874	0	38	166									
VPS13B	157680	broad.mit.edu	37	8	100866426	100866426	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:100866426G>A	uc003yiv.2	+	56	10995	c.10884G>A	c.(10882-10884)GCG>GCA	p.A3628A	VPS13B_uc003yiw.2_Silent_p.A3603A	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3628					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TCACCACTGCGAGGCAGCTTG	0.562		NaN											0	0	0	0.000602	0	4	47									
OC90	729330	broad.mit.edu	37	8	133053363	133053363	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:133053363C>G	uc003ytg.2	-	4	337	c.337G>C	c.(337-339)GAG>CAG	p.E113Q	OC90_uc011lix.1_Missense_Mutation_p.E129Q	NM_001080399	NP_001073868	Q02509	OC90_HUMAN	otoconin 90	129	Phospholipase A2-like 1.				lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			ovary(2)|skin(1)	3	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			CAGTCCATCTCAGCGGCCTCC	0.587		NaN											0	0	0	0.007291	0	21	81									
COL22A1	169044	broad.mit.edu	37	8	139701194	139701194	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:139701194C>A	uc003yvd.2	-	37	3275	c.2828G>T	c.(2827-2829)GGC>GTC	p.G943V	COL22A1_uc011ljo.1_Missense_Mutation_p.G243V	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	943	Pro-rich.|Gly-rich.|Collagen-like 8.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CCCTGGGGTGCCTCTGAGGCC	0.512		NaN								HNSCC(7;0.00092)			1	0	1.15088e-07	0.004007	1.19945e-07	12	66									
TSNARE1	203062	broad.mit.edu	37	8	143396398	143396398	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:143396398G>A	uc003ywk.2	-	8	1158	c.1040C>T	c.(1039-1041)TCA>TTA	p.S347L	TSNARE1_uc011lju.1_Missense_Mutation_p.S346L|TSNARE1_uc003ywj.2_Missense_Mutation_p.S347L|TSNARE1_uc003ywl.3_Missense_Mutation_p.S127L	NM_145003	NP_659440	Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	347					vesicle-mediated transport	integral to membrane					0	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					AATGGCATCTGAGAGCTGGGT	0.647		NaN											0	0	0	0.013537	0	11	72									
GLI4	2738	broad.mit.edu	37	8	144358969	144358969	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:144358969G>C	uc003yxx.2	+	4	1211	c.1126G>C	c.(1126-1128)GAG>CAG	p.E376Q	ZFP41_uc003yxv.2_RNA	NM_138465	NP_612474	P10075	GLI4_HUMAN	GLI-Kruppel family member GLI4	376						nucleus	DNA binding|zinc ion binding				0	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			GCACTACCGCGAGTAGCCGGG	0.736		NaN											0	0	0	0.004672	0	3	7									
SCRIB	23513	broad.mit.edu	37	8	144889748	144889748	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr8:144889748C>G	uc003yzp.1	-	16	2159	c.2152G>C	c.(2152-2154)GAG>CAG	p.E718Q	SCRIB_uc003yzo.1_Missense_Mutation_p.E718Q	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	718	Interaction with ARHGEF7.|Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CGAGCAGGCTCTATCAGCAGG	0.617		NaN											0	0	0	0.004482	0	7	84									
KIAA2026	158358	broad.mit.edu	37	9	5969048	5969048	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:5969048C>T	uc003zjq.3	-	3	1399	c.1183G>A	c.(1183-1185)GAA>AAA	p.E395K		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	395										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		CCCAGTTTTTCAGCACAGTTA	0.418		NaN											0	0	0	0.000602	0	5	19									
PTPRD	5789	broad.mit.edu	37	9	8484129	8484129	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:8484129C>T	uc003zkk.2	-	29	4114	c.3403G>A	c.(3403-3405)GAG>AAG	p.E1135K	PTPRD_uc003zkp.2_Missense_Mutation_p.E724K|PTPRD_uc003zkq.2_Missense_Mutation_p.E724K|PTPRD_uc003zkr.2_Missense_Mutation_p.E719K|PTPRD_uc003zks.2_Missense_Mutation_p.E714K|PTPRD_uc003zkl.2_Missense_Mutation_p.E1126K|PTPRD_uc003zkm.2_Missense_Mutation_p.E1122K|PTPRD_uc003zkn.2_Missense_Mutation_p.E724K|PTPRD_uc003zko.2_Missense_Mutation_p.E721K	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1135	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TTTATATTCTCATTTGCAGGT	0.383		NaN								TSP Lung(15;0.13)			0	0	0	0.00308	0	6	102									
PTPRD	5789	broad.mit.edu	37	9	8518022	8518022	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:8518022T>C	uc003zkk.2	-	20	2080	c.1369A>G	c.(1369-1371)ATG>GTG	p.M457V	PTPRD_uc003zkp.2_Missense_Mutation_p.M457V|PTPRD_uc003zkq.2_Missense_Mutation_p.M457V|PTPRD_uc003zkr.2_Missense_Mutation_p.M451V|PTPRD_uc003zks.2_Missense_Mutation_p.M447V|PTPRD_uc003zkl.2_Missense_Mutation_p.M457V|PTPRD_uc003zkm.2_Missense_Mutation_p.M444V|PTPRD_uc003zkn.2_Missense_Mutation_p.M457V|PTPRD_uc003zko.2_Missense_Mutation_p.M454V	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	457	Fibronectin type-III 2.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GTGGGATCCATTGTATAATAA	0.423		NaN								TSP Lung(15;0.13)			0	0	0	0.01441	0	61	125									
PSIP1	11168	broad.mit.edu	37	9	15486887	15486887	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:15486887C>T	uc003zlv.3	-	5	661	c.331G>A	c.(331-333)GAA>AAA	p.E111K	PSIP1_uc003zlw.3_Missense_Mutation_p.E111K|PSIP1_uc003zlz.3_Missense_Mutation_p.E111K|PSIP1_uc003zma.3_Missense_Mutation_p.E111K|PSIP1_uc003zly.2_Missense_Mutation_p.E111K	NM_033222	NP_150091	O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1 isoform 2	111					initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)		TCCTTTTCTTCAACTTCAACA	0.318		NaN											0	0	0	0.004878	0	37	59									
C9orf93	203238	broad.mit.edu	37	9	15920318	15920318	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:15920318C>G	uc003zmd.2	+	25	3966	c.3651C>G	c.(3649-3651)ATC>ATG	p.I1217M	C9orf93_uc003zme.2_Missense_Mutation_p.I1132M|C9orf93_uc011lmu.1_Missense_Mutation_p.I1225M	NM_173550	NP_775821	Q6TFL3	CI093_HUMAN	hypothetical protein LOC203238	1217	Potential.										0				GBM - Glioblastoma multiforme(50;4.84e-07)		GCACTAGAATCATGACATTAG	0.338		NaN											0	0	0	0.00308	0	8	49									
DENND4C	55667	broad.mit.edu	37	9	19324380	19324380	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:19324380C>T	uc003znq.2	+	9	1153	c.1120C>T	c.(1120-1122)CGT>TGT	p.R374C	DENND4C_uc011lnc.1_Intron	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	374	dDENN.					integral to membrane				ovary(1)|skin(1)	2						AAGTCGAGATCGTGCCTATGC	0.279		NaN											0	0	0	0.009535	0	29	71									
SLC24A2	25769	broad.mit.edu	37	9	19619665	19619665	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:19619665C>T	uc003zoa.1	-	3	1057	c.995G>A	c.(994-996)GGA>GAA	p.G332E	SLC24A2_uc003zob.1_Missense_Mutation_p.G332E	NM_020344	NP_065077	Q9UI40	NCKX2_HUMAN	solute carrier family 24	332	Cytoplasmic (Potential).				visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(3)	3				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		GGCAGAGCTTCCACCTCGCTG	0.488		NaN											0	0	0	0.00308	0	8	103									
SHB	6461	broad.mit.edu	37	9	37948664	37948664	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:37948664C>T	uc004aax.2	-	5	1882	c.1314G>A	c.(1312-1314)CAG>CAA	p.Q438Q		NM_003028	NP_003019	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein	438	SH2.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|skin(1)	3		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		GCTTGCTGGTCTGGCTGTTCC	0.647		NaN											0	0	0	0.001984	0	7	68									
HNRNPK	3190	broad.mit.edu	37	9	86586835	86586835	+	Silent	SNP	C	C	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:86586835C>A	uc004ang.3	-	11	1139	c.915G>T	c.(913-915)CGG>CGT	p.R305R	HNRNPK_uc011lsw.1_Silent_p.R65R|HNRNPK_uc004and.3_Silent_p.R65R|HNRNPK_uc004ank.3_Silent_p.R305R|HNRNPK_uc004anf.3_Silent_p.R305R|HNRNPK_uc004anh.3_Silent_p.R281R|HNRNPK_uc011lsx.1_Silent_p.R281R|HNRNPK_uc004ani.3_Silent_p.R305R|HNRNPK_uc004anj.3_Silent_p.R305R|HNRNPK_uc004ann.3_Silent_p.R281R|HNRNPK_uc004anl.3_Silent_p.R305R|HNRNPK_uc004anm.3_Silent_p.R305R|uc004ano.1_5'Flank|MIR7-1_hsa-mir-7-1|MI0000263_5'Flank	NM_031262	NP_112552	P61978	HNRPK_HUMAN	heterogeneous nuclear ribonucleoprotein K	305	5 X 4 AA repeats of G-X-G-G.|2 X 6 AA approximate repeats.|2 X 22 AA approximate repeats.|Interaction with ZIK1 (By similarity).				interspecies interaction between organisms|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of low-density lipoprotein particle clearance|signal transduction	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nuclear chromatin|nucleoplasm	protein binding|RNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|single-stranded DNA binding			skin(1)	1						GAGGAAGATTCCGAGCTCTGC	0.517		NaN											1	0	3.27435e-08	0.00245	3.43486e-08	13	100									
HNRNPK	3190	broad.mit.edu	37	9	86586966	86586966	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:86586966C>G	uc004ang.3	-	11	1008	c.784G>C	c.(784-786)GAC>CAC	p.D262H	HNRNPK_uc011lsw.1_Missense_Mutation_p.D22H|HNRNPK_uc004and.3_Missense_Mutation_p.D22H|HNRNPK_uc004ank.3_Missense_Mutation_p.D262H|HNRNPK_uc004anf.3_Missense_Mutation_p.D262H|HNRNPK_uc004anh.3_Missense_Mutation_p.D238H|HNRNPK_uc011lsx.1_Missense_Mutation_p.D238H|HNRNPK_uc004ani.3_Missense_Mutation_p.D262H|HNRNPK_uc004anj.3_Missense_Mutation_p.D262H|HNRNPK_uc004ann.3_Missense_Mutation_p.D238H|HNRNPK_uc004anl.3_Missense_Mutation_p.D262H|HNRNPK_uc004anm.3_Missense_Mutation_p.D262H|uc004ano.1_5'Flank|MIR7-1_hsa-mir-7-1|MI0000263_5'Flank	NM_031262	NP_112552	P61978	HNRPK_HUMAN	heterogeneous nuclear ribonucleoprotein K	262	5 X 4 AA repeats of G-X-G-G.|2 X 22 AA approximate repeats.|RNA-binding RGG-box.|2 X 6 AA approximate repeats.|Necessary for interaction with DDX1.|Interaction with ZIK1 (By similarity).				interspecies interaction between organisms|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of low-density lipoprotein particle clearance|signal transduction	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nuclear chromatin|nucleoplasm	protein binding|RNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|single-stranded DNA binding			skin(1)	1						GGCATTCTGTCAAAACCACCT	0.532		NaN											0	0	0	0.003163	0	14	68									
PTCH1	5727	broad.mit.edu	37	9	98209579	98209579	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:98209579C>T	uc004avk.3	-	23	4147	c.3959G>A	c.(3958-3960)AGA>AAA	p.R1320K	PTCH1_uc010mrn.2_Missense_Mutation_p.R112K|PTCH1_uc010mro.2_Missense_Mutation_p.R1169K|PTCH1_uc010mrp.2_Missense_Mutation_p.R1169K|PTCH1_uc010mrq.2_Missense_Mutation_p.R1169K|PTCH1_uc004avl.3_Missense_Mutation_p.R1169K|PTCH1_uc010mrr.2_Missense_Mutation_p.R1254K|PTCH1_uc004avm.3_Missense_Mutation_p.R1319K	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	1320	Cytoplasmic (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				AAAAGCGTCTCTGCGCGGTCT	0.667		NaN							Basal_Cell_Nevus_syndrome				0	0	0	0.006122	0	17	77									
PTCH1	5727	broad.mit.edu	37	9	98241349	98241349	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:98241349G>A	uc004avk.3	-	8	1336	c.1148C>T	c.(1147-1149)TCA>TTA	p.S383L	PTCH1_uc010mro.2_Missense_Mutation_p.S232L|PTCH1_uc010mrp.2_Missense_Mutation_p.S232L|PTCH1_uc010mrq.2_Missense_Mutation_p.S232L|PTCH1_uc004avl.3_Missense_Mutation_p.S232L|PTCH1_uc010mrr.2_Missense_Mutation_p.S317L|PTCH1_uc004avm.3_Missense_Mutation_p.S382L|PTCH1_uc010mrs.1_Missense_Mutation_p.S103L	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	383	Extracellular (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				GTTGATGTGTGAGACATACTC	0.552		NaN							Basal_Cell_Nevus_syndrome				0	0	0	0.003954	0	26	34									
STX17	55014	broad.mit.edu	37	9	102729973	102729973	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:102729973C>T	uc004bal.3	+	7	757	c.621C>T	c.(619-621)GTC>GTT	p.V207V	STX17_uc010msx.2_RNA|STX17_uc011lvd.1_RNA	NM_017919	NP_060389	P56962	STX17_HUMAN	syntaxin 17	207	t-SNARE coiled-coil homology.|Cytoplasmic (Potential).				intracellular protein transport|vesicle-mediated transport	endoplasmic reticulum|integral to membrane|nucleolus	SNAP receptor activity			large_intestine(1)	1		Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				CAGACCATGTCAACAGTGCTG	0.493		NaN											0	0	0	0.006999	0	35	46									
OR13F1	138805	broad.mit.edu	37	9	107266864	107266864	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:107266864G>A	uc011lvm.1	+	1	321	c.321G>A	c.(319-321)ATG>ATA	p.M107I		NM_001004485	NP_001004485	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F,	107	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)|skin(1)	3						CCCTTGCCATGGGCTCCACTG	0.522		NaN											0	0	0	0.00333	0	25	41									
CTNNAL1	8727	broad.mit.edu	37	9	111746665	111746665	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:111746665G>A	uc004bdo.1	-	5	733	c.691C>T	c.(691-693)CTT>TTT	p.L231F	CTNNAL1_uc010mts.1_5'Flank|CTNNAL1_uc010mtt.1_Missense_Mutation_p.L231F|CTNNAL1_uc004bdp.1_Missense_Mutation_p.L231F	NM_003798	NP_003789	Q9UBT7	CTNL1_HUMAN	catenin, alpha-like 1	231					cell adhesion|Rho protein signal transduction	actin cytoskeleton|cytosol|plasma membrane	cadherin binding|structural molecule activity			ovary(1)	1				STAD - Stomach adenocarcinoma(157;0.0768)		CACTTTTCAAGAACTGCCCTA	0.348		NaN											0	0	0	0.003755	0	32	106									
EPB41L4B	54566	broad.mit.edu	37	9	112042115	112042115	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:112042115G>A	uc004bdz.1	-	2	688	c.393C>T	c.(391-393)CTC>CTT	p.L131L	EPB41L4B_uc004bea.2_Silent_p.L131L	NM_019114	NP_061987	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	131	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3						GGGCAGAGTCGAGGAACTGGA	0.443		NaN											0	0	0	0.010729	0	8	43									
CEP110	11064	broad.mit.edu	37	9	123900853	123900853	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:123900853G>C	uc004bkx.1	+	14	2264	c.2233G>C	c.(2233-2235)GAG>CAG	p.E745Q	CEP110_uc004bky.1_Missense_Mutation_p.E349Q|CEP110_uc004bkz.1_Missense_Mutation_p.E193Q|CEP110_uc004bla.1_Missense_Mutation_p.E193Q	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	745	Potential.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						AGCAGAACTTGAGAAGGAAAG	0.398		NaN											0	0	0	0.00245	0	13	51									
DENND1A	57706	broad.mit.edu	37	9	126143804	126143804	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:126143804C>T	uc004bnz.1	-	22	3170	c.2937G>A	c.(2935-2937)CAG>CAA	p.Q979Q	DENND1A_uc011lzl.1_Silent_p.Q797Q|DENND1A_uc004bny.1_Silent_p.Q761Q|DENND1A_uc011lzm.1_Silent_p.Q990Q|DENND1A_uc010mwh.1_Silent_p.Q400Q	NM_020946	NP_065997	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A isoform 1	979	Pro-rich.					cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			ovary(2)	2						GCTTGGTTTTCTGTAACAAAT	0.647		NaN											0	0	0	0.004482	0	9	39									
CRAT	1384	broad.mit.edu	37	9	131860309	131860309	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:131860309C>T	uc004bxh.2	-	11	1729	c.1447G>A	c.(1447-1449)GAT>AAT	p.D483N	CRAT_uc004bxg.2_Missense_Mutation_p.D462N|CRAT_uc004bxk.3_Missense_Mutation_p.D462N	NM_000755	NP_000746	P43155	CACP_HUMAN	carnitine acetyltransferase precursor	483					energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA oxidase|transport	endoplasmic reticulum|mitochondrial inner membrane|peroxisomal matrix	carnitine O-acetyltransferase activity			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)	L-Carnitine(DB00583)	CTGGAGTCATCCATGGCCTTG	0.542		NaN											0	0	0	0.006214	0	9	129									
PTGDS	5730	broad.mit.edu	37	9	139873474	139873474	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:139873474C>T	uc004cke.2	+	2	219	c.144C>T	c.(142-144)CTC>CTT	p.L48L	PTGDS_uc004ckd.2_RNA|PTGDS_uc004ckf.2_RNA	NM_000954	NP_000945	P41222	PTGDS_HUMAN	prostaglandin D2 synthase, brain	48					prostaglandin biosynthetic process|regulation of circadian sleep/wake cycle, sleep	Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum	fatty acid binding|prostaglandin-D synthase activity|retinoid binding|transporter activity			ovary(1)	1	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GCGCGGGCCTCGCCTCCAACT	0.711		NaN											0	0	0	0.009096	0	4	31									
ABCA2	20	broad.mit.edu	37	9	139908491	139908491	+	Splice_Site	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr9:139908491C>T	uc011mem.1	-	27	4386	c.4238_splice	c.e27-1	p.E1413_splice	ABCA2_uc011mel.1_Splice_Site_p.E1414_splice|ABCA2_uc004ckl.1_Splice_Site_p.E1344_splice|ABCA2_uc004ckm.1_Splice_Site_p.E1444_splice|ABCA2_uc004ckn.1_Splice_Site	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2						cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GCCTCCACCTCTGTGCAGAGA	0.682		NaN											0	0	0	0.00308	0	7	17									
BMX	660	broad.mit.edu	37	X	15540529	15540529	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:15540529C>T	uc004cww.2	+	7	759	c.571C>T	c.(571-573)CTA>TTA	p.L191L	BMX_uc004cwx.3_Silent_p.L191L|BMX_uc004cwy.3_Silent_p.L191L	NM_203281	NP_975010	P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	191					cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(3)|ovary(2)	5	Hepatocellular(33;0.183)					AAGTACCACTCTAGCCCAATA	0.428		NaN											0	0	0	0.01441	0	82	24									
PORCN	64840	broad.mit.edu	37	X	48372644	48372644	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:48372644G>A	uc010nie.1	+	9	894	c.736G>A	c.(736-738)GAG>AAG	p.E246K	PORCN_uc004djr.1_Missense_Mutation_p.E241K|PORCN_uc004djs.1_Missense_Mutation_p.E235K|PORCN_uc004djt.1_Missense_Mutation_p.E164K|PORCN_uc011mlx.1_Missense_Mutation_p.E164K|PORCN_uc004dju.1_Missense_Mutation_p.E104K|PORCN_uc004djv.1_Missense_Mutation_p.E246K|PORCN_uc004djw.1_Missense_Mutation_p.E240K	NM_203475	NP_982301	Q9H237	PORCN_HUMAN	porcupine isoform D	246	Extracellular (Potential).				Wnt receptor signaling pathway	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(2)|central_nervous_system(1)	3						GCGAGCCTACGAGAGTGCTGT	0.597		NaN											0	0	0	0.012319	0	19	44									
GPR173	54328	broad.mit.edu	37	X	53106308	53106308	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:53106308C>T	uc004dru.2	+	2	763	c.505C>T	c.(505-507)CGG>TGG	p.R169W		NM_018969	NP_061842	Q9NS66	GP173_HUMAN	G protein-coupled receptor 173	169	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						CAAGTTTATTCGGGAGGAGGA	0.562		NaN											0	0	0	0.001984	0	6	12									
MAGEH1	28986	broad.mit.edu	37	X	55479335	55479335	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:55479335C>T	uc004dum.2	+	1	798	c.528C>T	c.(526-528)GTC>GTT	p.V176V		NM_014061	NP_054780	Q9H213	MAGH1_HUMAN	melanoma antigen, family H, 1 protein	176	MAGE.				apoptosis					ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						AACTGAAAGTCATGCATTTTG	0.512		NaN											0	0	0	0.009718	0	43	15									
SPIN2A	54466	broad.mit.edu	37	X	57162619	57162619	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:57162619C>G	uc004dvb.2	-	2	783	c.412G>C	c.(412-414)GAG>CAG	p.E138Q		NM_019003	NP_061876	Q99865	SPI2A_HUMAN	spindlin family, member 2	138					cell cycle|gamete generation						0						TGCTCTCCCTCAAACATGTGT	0.418		NaN											0	0	0	0.00623	0	38	103									
MTMR8	55613	broad.mit.edu	37	X	63488550	63488550	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:63488550G>A	uc004dvs.2	-	14	2050	c.1982C>T	c.(1981-1983)TCT>TTT	p.S661F	MTMR8_uc011mou.1_Intron	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	661						nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						AGTGGCCTCAGAGATGTCCAT	0.567		NaN											0	0	0	0.009096	0	4	32									
TAF7L	54457	broad.mit.edu	37	X	100542501	100542501	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:100542501C>T	uc004ehb.2	-	2	301	c.289G>A	c.(289-291)GAA>AAA	p.E97K	TAF7L_uc004eha.2_Missense_Mutation_p.E11K|TAF7L_uc004ehc.1_Missense_Mutation_p.E11K	NM_024885	NP_079161	Q5H9L4	TAF7L_HUMAN	TATA box binding protein-associated factor, RNA	97					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			breast(1)	1						TTCTCAACTTCATCAGGAACT	0.348		NaN											0	0	0	0.009096	0	4	31									
BHLHB9	80823	broad.mit.edu	37	X	102004757	102004757	+	Silent	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:102004757C>T	uc010nog.2	+	4	1405	c.834C>T	c.(832-834)ATC>ATT	p.I278I	BHLHB9_uc011mrq.1_Silent_p.I278I|BHLHB9_uc011mrr.1_Silent_p.I278I|BHLHB9_uc011mrs.1_Silent_p.I278I|BHLHB9_uc011mrt.1_Silent_p.I278I|BHLHB9_uc004ejo.2_Silent_p.I278I|BHLHB9_uc011mru.1_Silent_p.I278I|BHLHB9_uc011mrv.1_Silent_p.I278I	NM_001142526	NP_001135998	Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class	278						cytoplasm|nucleus	binding			ovary(2)	2						CACAGCCTATCCCTGAGTGTC	0.483		NaN											0	0	0	0.014323	0	20	53									
SERPINA7	6906	broad.mit.edu	37	X	105281031	105281031	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:105281031G>A	uc004eme.1	-	1	35	c.19C>T	c.(19-21)CTG>TTG	p.L7L	SERPINA7_uc010npd.2_Silent_p.L7L|SERPINA7_uc010npe.1_Silent_p.L7L	NM_000354	NP_000345	P05543	THBG_HUMAN	serine (or cysteine) proteinase inhibitor, clade	7					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity				0					Levothyroxine(DB00451)|Liothyronine(DB00279)	AAGAGAACCAGATACAGGAAT	0.458		NaN											0	0	0	0.00308	0	7	59									
TBC1D8B	54885	broad.mit.edu	37	X	106066677	106066677	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:106066677C>G	uc004emo.2	+	5	973	c.808C>G	c.(808-810)CCT>GCT	p.P270A	MORC4_uc004emp.3_Intron|TBC1D8B_uc004emm.2_Missense_Mutation_p.P270A|TBC1D8B_uc004emn.2_Missense_Mutation_p.P270A	NM_017752	NP_060222	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	270						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(2)|central_nervous_system(1)|skin(1)	4						CCTTTATAATCCTCTACAGAT	0.313		NaN											0	0	0	0.01441	0	55	21									
VSIG1	340547	broad.mit.edu	37	X	107319443	107319443	+	Silent	SNP	A	A	G			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:107319443A>G	uc004eno.2	+	6	986	c.825A>G	c.(823-825)GAA>GAG	p.E275E	VSIG1_uc011msk.1_Silent_p.E311E	NM_182607	NP_872413	Q86XK7	VSIG1_HUMAN	V-set and immunoglobulin domain containing 1	275	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2						CCATCGCGGAACTTGAGTAAG	0.403		NaN											0	0	0	0.01441	0	47	18									
GLUD2	2747	broad.mit.edu	37	X	120181908	120181908	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:120181908C>T	uc004eto.2	+	1	447	c.370C>T	c.(370-372)CGC>TGC	p.R124C		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	124					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	CCCCATCCGGCGCGACGACGG	0.642		NaN											0	0	0	0.00499	0	18	24									
SMARCA1	6594	broad.mit.edu	37	X	128599886	128599886	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:128599886G>C	uc004eun.3	-	22	2865	c.2752C>G	c.(2752-2754)CAA>GAA	p.Q918E	SMARCA1_uc004eup.3_Missense_Mutation_p.Q906E|SMARCA1_uc011muk.1_Missense_Mutation_p.Q918E|SMARCA1_uc011mul.1_Missense_Mutation_p.Q906E	NM_003069	NP_003060	P28370	SMCA1_HUMAN	SWI/SNF-related matrix-associated	918					ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			ovary(3)|skin(1)	4						CGTTCAATTTGAGCCATAATT	0.328		NaN											0	0	0	0.004007	0	16	58									
HTATSF1	27336	broad.mit.edu	37	X	135593696	135593696	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:135593696G>T	uc004ezw.2	+	10	2214	c.1792G>T	c.(1792-1794)GAA>TAA	p.E598*	HTATSF1_uc004ezx.2_Nonsense_Mutation_p.E598*	NM_001163280	NP_001156752	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	598	Asp/Glu-rich (acidic).|Mediates interaction with the P-TEFb complex.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					AAATGACTCTGAAAACTCCGA	0.388		NaN											1	0	8.58068e-18	0.007291	9.33695e-18	29	50									
L1CAM	3897	broad.mit.edu	37	X	153135920	153135920	+	Silent	SNP	G	G	A			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:153135920G>A	uc004fjb.2	-	7	837	c.729C>T	c.(727-729)CTC>CTT	p.L243L	L1CAM_uc004fjc.2_Silent_p.L243L|L1CAM_uc010nuo.2_Silent_p.L238L|L1CAM_uc004fjd.1_Silent_p.L57L|L1CAM_uc004fje.1_Silent_p.L238L	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	243	Extracellular (Potential).|Ig-like C2-type 3.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGGTGGGGAAGAGCAGGCGCG	0.602		NaN											0	0	0	0.009096	0	4	20									
TKTL1	8277	broad.mit.edu	37	X	153557916	153557916	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chrX:153557916C>T	uc004fkg.2	+	13	1855	c.1669C>T	c.(1669-1671)CAG>TAG	p.Q557*	TKTL1_uc011mzl.1_Nonsense_Mutation_p.Q551*|TKTL1_uc011mzm.1_Nonsense_Mutation_p.Q353*|TKTL1_uc004fkh.2_Nonsense_Mutation_p.Q501*	NM_012253	NP_036385	P51854	TKTL1_HUMAN	transketolase-like 1 isoform a	557					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			ovary(3)|skin(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TCCTGACATTCAGGTTCATTC	0.542		NaN											0	0	0	0.00308	0	8	75									
NASP	4678	broad.mit.edu	37	1	46082055	46082055	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:46082055delC	uc001coi.1	+	12	2171	c.2069delC	c.(2068-2070)TCAfs	p.S690fs	NASP_uc001coh.1_Frame_Shift_Del_p.S692fs|NASP_uc001coj.1_Frame_Shift_Del_p.S351fs|NASP_uc010olr.1_Frame_Shift_Del_p.S626fs|NASP_uc001col.1_Frame_Shift_Del_p.S198fs	NM_002482	NP_002473	P49321	NASP_HUMAN	nuclear autoantigenic sperm protein isoform 2	690					blastocyst development|cell cycle|cell proliferation|DNA replication|histone exchange|protein transport	cytoplasm|nucleus	Hsp90 protein binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.211)					GGAGGCTCTTCAGTCTCCATG	0.368		NaN											NaN	NaN	NaN	NaN	NaN	79	129	---	---							
USP33	23032	broad.mit.edu	37	1	78180315	78180315	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr1:78180315delA	uc001dht.2	-	20	2639	c.2292delT	c.(2290-2292)TTTfs	p.F764fs	USP33_uc001dhs.2_Frame_Shift_Del_p.F485fs|USP33_uc001dhu.2_Frame_Shift_Del_p.F733fs|USP33_uc001dhv.2_Frame_Shift_Del_p.F569fs|USP33_uc001dhw.2_Frame_Shift_Del_p.F756fs	NM_015017	NP_055832	Q8TEY7	UBP33_HUMAN	ubiquitin specific protease 33 isoform 1	764	DUSP 1.				axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(2)|ovary(1)	3						GAATACAAAGAAAGTCATTAT	0.368		NaN											NaN	NaN	NaN	NaN	NaN	43	82	---	---							
HIP1R	9026	broad.mit.edu	37	12	123345546	123345546	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr12:123345546delG	uc001udj.1	+	29	2909	c.2850delG	c.(2848-2850)GTGfs	p.V950fs	HIP1R_uc001udk.1_Frame_Shift_Del_p.V215fs	NM_003959	NP_003950	O75146	HIP1R_HUMAN	huntingtin interacting protein-1-related	950	I/LWEQ.				receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		CCAATGTGGTGGCCTCCACCA	0.637		NaN											NaN	NaN	NaN	NaN	NaN	20	18	---	---							
SACS	26278	broad.mit.edu	37	13	23915245	23915246	+	In_Frame_Ins	INS	-	-	TTC			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr13:23915245_23915246insTTC	uc001uon.2	-	10	3358_3359	c.2769_2770insGAA	c.(2767-2772)insGAA	p.923_924insE	SACS_uc001uoo.2_In_Frame_Ins_p.776_777insE|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	923_924					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AATATTGCCAATTCTTGAATAA	0.376		NaN											NaN	NaN	NaN	NaN	NaN	41	98	---	---							
KCTD8	386617	broad.mit.edu	37	4	44176909	44176909	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr4:44176909delC	uc003gwu.2	-	2	1604	c.1320delG	c.(1318-1320)ATGfs	p.M440fs		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	440						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						TACACTTTTTCATTTCTTCTT	0.398		NaN								HNSCC(17;0.042)			NaN	NaN	NaN	NaN	NaN	36	116	---	---							
CTNND2	1501	broad.mit.edu	37	5	11199639	11199639	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr5:11199639delC	uc003jfa.1	-	11	2041	c.1896delG	c.(1894-1896)CTGfs	p.L632fs	CTNND2_uc010itt.2_Frame_Shift_Del_p.L541fs|CTNND2_uc011cmy.1_Frame_Shift_Del_p.L295fs|CTNND2_uc011cmz.1_Frame_Shift_Del_p.L199fs|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Frame_Shift_Del_p.L199fs	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	632	ARM 4.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						CACAGTTTTTCAGGGCAATTT	0.498		NaN											NaN	NaN	NaN	NaN	NaN	59	81	---	---							
MYLIP	29116	broad.mit.edu	37	6	16144013	16144022	+	Frame_Shift_Del	DEL	TCGTGCTCTT	TCGTGCTCTT	-			TCGA-FD-A3SS-01A-12D-A22Z-08	TCGA-FD-A3SS-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f1a6ff39-9f3b-4fba-b5a9-1f9d551002e9	5c843250-8dd1-488d-a5d3-76768e7ccec2	g.chr6:16144013_16144022delTCGTGCTCTT	uc003nbq.2	+	5	983_992	c.746_755delTCGTGCTCTT	c.(745-756)ATCGTGCTCTTGfs	p.I249fs	MYLIP_uc003nbr.2_Frame_Shift_Del_p.I68fs	NM_013262	NP_037394	Q8WY64	MYLIP_HUMAN	myosin regulatory light chain interacting	249_252	FERM.				cellular component movement|nervous system development	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|ubiquitin-protein ligase activity|zinc ion binding			pancreas(1)	1	Breast(50;0.0799)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.241)			GGGAACAGCATCGTGCTCTTGTTTAAAATG	0.519		NaN											NaN	NaN	NaN	NaN	NaN	40	116	---	---							
