Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
AGRN	375790	broad.mit.edu	37	1	984698	984698	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:984698C>T	uc001ack.1	+	25	4431	c.4381C>T	c.(4381-4383)CGG>TGG	p.R1461W		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	1461	Laminin G-like 1.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		GGAGCTGTCCCGGCACTGGCG	0.687		NaN											0	0	0	1	0	15	24									
MXRA8	54587	broad.mit.edu	37	1	1290868	1290868	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:1290868G>C	uc001aew.2	-	3	369	c.338C>G	c.(337-339)TCG>TGG	p.S113W	MXRA8_uc001aex.3_Missense_Mutation_p.S113W|MXRA8_uc001aey.3_Missense_Mutation_p.S113W|MXRA8_uc010nyl.1_Missense_Mutation_p.S113W|MXRA8_uc001aez.2_Intron|MXRA8_uc001afa.2_Missense_Mutation_p.S104W	NM_032348	NP_115724	Q9BRK3	MXRA8_HUMAN	matrix-remodelling associated 8 precursor	113	Extracellular (Potential).|Ig-like V-type 1.					integral to membrane					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GTCGAAGGCCGAGGCCGAGAG	0.468		NaN											0	0	0	1	0	9	5									
MEGF6	1953	broad.mit.edu	37	1	3417236	3417236	+	Silent	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:3417236G>A	uc001akl.2	-	21	2895	c.2668C>T	c.(2668-2670)CTG>TTG	p.L890L	MEGF6_uc001akk.2_Silent_p.L785L	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	890	EGF-like 15.					extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		GCCTCACACAGACACAGGCCG	0.602		NaN											0	0	0	1	0	4	7									
KCNAB2	8514	broad.mit.edu	37	1	6158568	6158568	+	Silent	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:6158568C>T	uc009vlv.1	+	16	1173	c.1038C>T	c.(1036-1038)TCC>TCT	p.S346S	KCNAB2_uc001alv.1_Silent_p.S346S|KCNAB2_uc001alw.1_Silent_p.S332S|KCNAB2_uc001alx.1_Silent_p.S346S|KCNAB2_uc001aly.1_Silent_p.S394S|KCNAB2_uc009vlw.1_Silent_p.S279S|KCNAB2_uc001alu.2_3'UTR	NM_003636	NP_003627	Q13303	KCAB2_HUMAN	potassium voltage-gated channel, shaker-related	346						cytoplasm|integral to membrane|juxtaparanode region of axon	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity				0	Ovarian(185;0.0634)	all_cancers(23;5.85e-39)|all_epithelial(116;4.88e-22)|all_lung(118;4.21e-08)|Lung NSC(185;9.77e-07)|all_hematologic(16;2.78e-06)|all_neural(13;3.18e-06)|Acute lymphoblastic leukemia(12;0.000272)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00106)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0393)|Medulloblastoma(700;0.211)		Epithelial(90;6.9e-37)|GBM - Glioblastoma multiforme(13;8.8e-31)|OV - Ovarian serous cystadenocarcinoma(86;1.45e-19)|Colorectal(212;2.46e-07)|COAD - Colon adenocarcinoma(227;2.07e-05)|Kidney(185;7.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00131)|BRCA - Breast invasive adenocarcinoma(365;0.00133)|STAD - Stomach adenocarcinoma(132;0.00391)|READ - Rectum adenocarcinoma(331;0.0649)		TGTCATCTTCCATTATCCACG	0.537		NaN											0	0	0	1	0	17	30									
LRRC41	10489	broad.mit.edu	37	1	46746887	46746887	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:46746887G>A	uc001cpn.2	-	5	1710	c.1666C>T	c.(1666-1668)CGT>TGT	p.R556C	LRRC41_uc010omb.1_Missense_Mutation_p.R556C	NM_006369	NP_006360	Q15345	LRC41_HUMAN	MUF1 protein	556										ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(166;0.155)					TGGTCAACACGAATAGAGAGG	0.597		NaN											0	0	0	1	0	34	66									
LRRC7	57554	broad.mit.edu	37	1	70504295	70504295	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:70504295G>A	uc001dep.2	+	19	2704	c.2674G>A	c.(2674-2676)GTA>ATA	p.V892I	LRRC7_uc009wbg.2_Missense_Mutation_p.V176I|LRRC7_uc001deq.2_Missense_Mutation_p.V133I	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	892						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TTCTCCAGGCGTACCATGGGA	0.423		NaN											0	0	0	1	0	48	82									
TTLL7	79739	broad.mit.edu	37	1	84399296	84399296	+	Silent	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:84399296G>A	uc001djc.2	-	9	1438	c.1042C>T	c.(1042-1044)CTG>TTG	p.L348L	TTLL7_uc001djb.2_RNA|TTLL7_uc001djd.2_RNA|TTLL7_uc001dje.2_RNA|TTLL7_uc001djf.2_RNA|TTLL7_uc001djg.2_RNA	NM_024686	NP_078962	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	348	TTL.				cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			ovary(1)	1				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		CTTACCTCCAGAAGCCATGGC	0.373		NaN											0	0	0	1	0	67	71									
DBT	1629	broad.mit.edu	37	1	100701061	100701061	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:100701061C>T	uc001dta.2	-	3	215	c.182G>A	c.(181-183)CGT>CAT	p.R61H	DBT_uc010oug.1_Translation_Start_Site	NM_001918	NP_001909	P11182	ODB2_HUMAN	dihydrolipoamide branched chain transacylase	61					branched chain family amino acid catabolic process|fatty-acyl-CoA biosynthetic process	microtubule cytoskeleton|mitochondrial alpha-ketoglutarate dehydrogenase complex|mitochondrial nucleoid	acyltransferase activity|cofactor binding|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity|protein binding			pancreas(1)	1		all_epithelial(167;5.4e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0739)|all cancers(265;0.123)|COAD - Colon adenocarcinoma(174;0.154)|Lung(183;0.199)		AACCTGTCCACGGAGAGCTTC	0.333		NaN											0	0	0	1	0	8	72									
SCNM1	79005	broad.mit.edu	37	1	151141526	151141526	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:151141526G>A	uc001ewz.2	+	7	770	c.658G>A	c.(658-660)GAT>AAT	p.D220N	SCNM1_uc009wmn.2_RNA	NM_024041	NP_076946	Q9BWG6	SCNM1_HUMAN	sodium channel modifier 1	220					mRNA processing|RNA splicing	nucleus	metal ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GTTTGACTCTGATGAGGAGGA	0.423		NaN											0	0	0	1	0	52	68									
HRNR	388697	broad.mit.edu	37	1	152188366	152188366	+	Silent	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:152188366G>A	uc001ezt.1	-	3	5815	c.5739C>T	c.(5737-5739)CAC>CAT	p.H1913H		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	1913	21.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCTAGATCCGTGTTGTTCAC	0.557		NaN											0	0	0	1	0	65	875									
FCRL2	79368	broad.mit.edu	37	1	157739894	157739894	+	Silent	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:157739894G>A	uc001fre.2	-	4	416	c.357C>T	c.(355-357)ATC>ATT	p.I119I	FCRL2_uc001frd.2_5'Flank|FCRL2_uc010phz.1_Silent_p.I119I|FCRL2_uc009wsp.2_Intron|FCRL2_uc010pia.1_Silent_p.I119I	NM_030764	NP_110391	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2 precursor	119	Extracellular (Potential).|Ig-like C2-type 2.				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			ovary(1)|pancreas(1)	2	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GACCCCCTTCGATGGGCTGGA	0.527		NaN											0	0	0	1	0	40	41									
SPTA1	6708	broad.mit.edu	37	1	158585162	158585162	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:158585162C>T	uc001fst.1	-	48	6831	c.6632G>A	c.(6631-6633)CGT>CAT	p.R2211H		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	2211	Spectrin 21.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GGTTAGTTGACGCTTCATCGC	0.483		NaN											0	0	0	1	0	104	85									
LY9	4063	broad.mit.edu	37	1	160769712	160769712	+	Silent	SNP	T	T	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:160769712T>A	uc001fwu.2	+	2	344	c.294T>A	c.(292-294)ATT>ATA	p.I98I	LY9_uc001fwt.2_Silent_p.I98I|LY9_uc010pjs.1_Silent_p.I98I|LY9_uc001fwv.2_Silent_p.I98I|LY9_uc001fww.2_Silent_p.I98I|LY9_uc001fwx.2_Silent_p.I98I|LY9_uc001fwy.1_5'UTR	NM_002348	NP_002339	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9 isoform a	98	Extracellular (Potential).|Ig-like V-type 1.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			ATGTAACCATTATGGTCAAAA	0.468		NaN											0	0	0	1	0	70	90									
ATF6	22926	broad.mit.edu	37	1	161789557	161789557	+	Silent	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:161789557G>A	uc001gbr.2	+	8	1111	c.1044G>A	c.(1042-1044)CTG>CTA	p.L348L	ATF6_uc001gbq.1_Silent_p.L348L	NM_007348	NP_031374	P18850	ATF6A_HUMAN	activating transcription factor 6	348	Cytoplasmic (Potential).|Leucine-zipper.				positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|skin(1)	3	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			ACGAGCAACTGAAGAAAGAAA	0.448		NaN											0	0	0	1	0	19	27									
RASAL2	9462	broad.mit.edu	37	1	178063703	178063703	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:178063703G>A	uc001glq.2	+	1	840	c.76G>A	c.(76-78)GAC>AAC	p.D26N	RASAL2_uc009wxb.2_Missense_Mutation_p.D26N|LOC100302401_uc001gln.1_5'Flank|LOC100302401_uc001glo.1_5'Flank|RASAL2_uc009wxa.2_RNA	NM_170692	NP_733793	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 2	Error:Variant_position_missing_in_Q9UJF2_after_alignment					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5						GCTGGAGTCCGACTCGCCGCT	0.706		NaN											0	0	0	1	0	11	6									
TMCC2	9911	broad.mit.edu	37	1	205210828	205210828	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:205210828G>A	uc001hbz.1	+	3	847	c.403G>A	c.(403-405)GCC>ACC	p.A135T	TMCC2_uc010prf.1_Missense_Mutation_p.A57T	NM_014858	NP_055673	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	135						integral to membrane	protein binding			pancreas(1)	1	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			CGTCTCCTACGCCATGTCCCT	0.662		NaN											0	0	0	1	0	19	35									
TP53BP2	7159	broad.mit.edu	37	1	223984287	223984287	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:223984287C>T	uc010pvb.1	-	13	2246	c.1954G>A	c.(1954-1956)GGT>AGT	p.G652S	TP53BP2_uc001hod.2_Missense_Mutation_p.G523S|TP53BP2_uc010puz.1_5'UTR|TP53BP2_uc010pva.1_Missense_Mutation_p.G291S	NM_001031685	NP_001026855	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2 isoform 1	646					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)		ACAGGCTTACCATATACTAAT	0.398		NaN											0	0	0	1	0	34	77									
OBSCN	84033	broad.mit.edu	37	1	228399647	228399647	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:228399647C>T	uc009xez.1	+	2	207	c.163C>T	c.(163-165)CGC>TGC	p.R55C	OBSCN_uc001hsn.2_Missense_Mutation_p.R55C|uc001hsm.1_Intron	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	55	Ig-like 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GGCCGGCGCGCGCTTCCGTCT	0.687		NaN											0	0	0	1	0	11	6									
RYR2	6262	broad.mit.edu	37	1	237756779	237756779	+	Missense_Mutation	SNP	T	T	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:237756779T>A	uc001hyl.1	+	33	4399	c.4279T>A	c.(4279-4281)TAT>AAT	p.Y1427N		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1427	Cytoplasmic (By similarity).|B30.2/SPRY 3.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTCACAGTACTATTACTCAGT	0.388		NaN											0	0	0	1	0	12	46									
PPPDE1	51029	broad.mit.edu	37	1	244868861	244868861	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:244868861C>G	uc001iao.2	+	5	619	c.355C>G	c.(355-357)CTT>GTT	p.L119V	PPPDE1_uc001iap.2_Missense_Mutation_p.L86V|PPPDE1_uc001iaq.1_RNA	NM_016076	NP_057160	Q9BSY9	PPDE1_HUMAN	PPPDE peptidase domain containing 1	119	PPPDE peptidase.									breast(3)	3						TCTGTAGATTCTTTGTGGGAA	0.522		NaN											0	0	0	1	0	55	69									
OR2T8	343172	broad.mit.edu	37	1	248084484	248084484	+	Silent	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:248084484G>A	uc010pzc.1	+	1	165	c.165G>A	c.(163-165)ACG>ACA	p.T55T		NM_001005522	NP_001005522	A6NH00	OR2T8_HUMAN	olfactory receptor, family 2, subfamily T,	55	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0211)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GGCTCCACACGCCCATGTACT	0.522		NaN											0	0	0	1	0	62	95									
CUBN	8029	broad.mit.edu	37	10	16883020	16883020	+	Silent	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr10:16883020C>T	uc001ioo.2	-	61	9742	c.9690G>A	c.(9688-9690)GCG>GCA	p.A3230A		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3230	CUB 24.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CAGCCAAGTTCGCATTTTCAC	0.368		NaN											0	0	0	1	0	14	15									
MASTL	84930	broad.mit.edu	37	10	27459681	27459681	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr10:27459681C>G	uc001itm.2	+	8	2432	c.1793C>G	c.(1792-1794)TCT>TGT	p.S598C	MASTL_uc001itl.2_Missense_Mutation_p.S598C|MASTL_uc009xkw.1_Missense_Mutation_p.S598C|MASTL_uc009xkx.1_RNA	NM_032844	NP_116233	Q96GX5	GWL_HUMAN	microtubule associated serine/threonine	598	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						AAAGAATCCTCTTTTGAAGAA	0.368		NaN											0	0	0	1	0	10	23									
RET	5979	broad.mit.edu	37	10	43623613	43623613	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr10:43623613G>C	uc001jal.2	+	20	3431	c.3241G>C	c.(3241-3243)GAT>CAT	p.D1081H		NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	1081	Cytoplasmic (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	CACGAGAGCTGATGGCACTAA	0.438		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				0	0	0	1	0	41	82									
ERCC6	2074	broad.mit.edu	37	10	50740776	50740776	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr10:50740776G>A	uc001jhs.3	-	2	389	c.235C>T	c.(235-237)CAG>TAG	p.Q79*	PGBD3_uc009xoe.2_Nonsense_Mutation_p.Q79*|PGBD3_uc001jhu.2_Nonsense_Mutation_p.Q79*	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	79					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						GCCTGGATCTGATGTCGGTCG	0.622		NaN						Direct_reversal_of_damage|NER					0	0	0	1	0	25	33									
PRF1	5551	broad.mit.edu	37	10	72360386	72360386	+	Silent	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr10:72360386C>T	uc009xqg.2	-	2	434	c.273G>A	c.(271-273)GCG>GCA	p.A91A	PRF1_uc001jrf.3_Silent_p.A91A	NM_001083116	NP_001076585	P14222	PERF_HUMAN	perforin 1 precursor	91	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						AGTTGGTGAGCGCCAGAGGCA	0.657		NaN	M			various leukaemia|lymphoma	Type 2 familial hemophagocytic lymphohistiocytosis		Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	1	0	18	16									
SORCS3	22986	broad.mit.edu	37	10	106916969	106916969	+	Missense_Mutation	SNP	A	A	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr10:106916969A>T	uc001kyi.1	+	10	1783	c.1556A>T	c.(1555-1557)AAC>ATC	p.N519I		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	519	BNR 4.|Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		ATCACTTACAACAAAGGCAGG	0.512		NaN											0	0	0	1	0	27	24									
C10orf82	143379	broad.mit.edu	37	10	118424359	118424359	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr10:118424359C>G	uc001lcr.2	-	4	429	c.374G>C	c.(373-375)AGA>ACA	p.R125T	C10orf82_uc001lcs.1_3'UTR	NM_144661	NP_653262	Q8WW14	CJ082_HUMAN	hypothetical protein LOC143379	125											0				all cancers(201;0.0143)		GACAGTGTATCTCGTGCCACA	0.522		NaN											0	0	0	1	0	49	64									
KNDC1	85442	broad.mit.edu	37	10	135020668	135020668	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr10:135020668G>A	uc001llz.1	+	20	3608	c.3607G>A	c.(3607-3609)GAG>AAG	p.E1203K	KNDC1_uc001lma.1_3'UTR	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	1203					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		CTGGGGCCTGGAGCCCTGCAC	0.657		NaN											0	0	0	1	0	4	8									
PLEKHA7	144100	broad.mit.edu	37	11	16838384	16838384	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr11:16838384C>T	uc001mmo.2	-	11	1844	c.1829G>A	c.(1828-1830)GGG>GAG	p.G610E	PLEKHA7_uc010rcu.1_Missense_Mutation_p.G610E|PLEKHA7_uc010rcv.1_Missense_Mutation_p.G184E|PLEKHA7_uc001mmn.2_Missense_Mutation_p.G318E	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	610	Interaction with CTNND1.				epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						TGGAGAATCCCCCAGCGAGAT	0.657		NaN											0	0	0	1	0	49	5									
ALX4	60529	broad.mit.edu	37	11	44296955	44296955	+	Silent	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr11:44296955G>A	uc001myb.2	-	2	824	c.720C>T	c.(718-720)GAC>GAT	p.D240D		NM_021926	NP_068745	Q9H161	ALX4_HUMAN	aristaless-like homeobox 4	240	Homeobox.				hair follicle development						0						GCGCATACACGTCTGGGTAGT	0.617		NaN											0	0	0	1	0	106	13									
PATL1	219988	broad.mit.edu	37	11	59415362	59415362	+	Silent	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr11:59415362C>T	uc001noe.3	-	15	1901	c.1758G>A	c.(1756-1758)CAG>CAA	p.Q586Q	PATL1_uc009yms.1_Silent_p.Q556Q	NM_152716	NP_689929	Q86TB9	PATL1_HUMAN	protein associated with topoisomerase II homolog	586	Region C.				cytoplasmic mRNA processing body assembly|deadenylation-dependent decapping of nuclear-transcribed mRNA	cytoplasmic mRNA processing body	protein binding|RNA binding			ovary(1)	1						TACACATGATCTGTACAAAGT	0.438		NaN											0	0	0	1	0	20	30									
MS4A12	54860	broad.mit.edu	37	11	60264894	60264894	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr11:60264894G>T	uc001npr.2	+	2	160	c.103G>T	c.(103-105)GGT>TGT	p.G35C	MS4A12_uc009ynb.2_Missense_Mutation_p.G35C	NM_017716	NP_060186	Q9NXJ0	M4A12_HUMAN	membrane-spanning 4-domains, subfamily A, member	35	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						ACAGCCTCTGGGTTCAATCAA	0.507		NaN											1	0	4.81439e-37	1	5.01864e-37	80	86									
INPPL1	3636	broad.mit.edu	37	11	71949104	71949104	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr11:71949104G>T	uc001osf.2	+	27	3718	c.3571G>T	c.(3571-3573)GGG>TGG	p.G1191W	INPPL1_uc001osg.2_Missense_Mutation_p.G949W	NM_001567	NP_001558	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	1191					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			skin(2)|ovary(1)|breast(1)	4						CCTGCAGGGCGGGCGGGCCAG	0.657		NaN									OREG0021191	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	0.000586117	1	0.000589545	23	19									
PPME1	51400	broad.mit.edu	37	11	73958134	73958134	+	Silent	SNP	A	A	G			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr11:73958134A>G	uc001ouw.2	+	11	1074	c.975A>G	c.(973-975)AGA>AGG	p.R325R	PPME1_uc009yty.2_Silent_p.R209R|PPME1_uc001oux.2_Silent_p.R138R	NM_016147	NP_057231	Q9Y570	PPME1_HUMAN	protein phosphatase methylesterase 1	325					protein demethylation		carboxylesterase activity|protein C-terminal methylesterase activity|protein phosphatase 2A binding|protein phosphatase inhibitor activity|protein phosphatase type 2A regulator activity				0	Breast(11;3.29e-05)					GTGTTGATAGATTGGATAAAG	0.348		NaN											0	0	0	1	0	15	17									
P4HA3	283208	broad.mit.edu	37	11	74009284	74009284	+	Missense_Mutation	SNP	C	C	G	rs142768884	byFrequency	TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr11:74009284C>G	uc001ouz.2	-	4	733	c.690G>C	c.(688-690)TTG>TTC	p.L230F	P4HA3_uc001ouy.3_RNA|P4HA3_uc010rrj.1_Missense_Mutation_p.L230F	NM_182904	NP_878907	Q7Z4N8	P4HA3_HUMAN	prolyl 4-hydroxylase, alpha III subunit	230	TPR.					endoplasmic reticulum lumen	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			skin(1)	1	Breast(11;2.31e-05)					CCAAGTGATCCAAGGCATCTT	0.413		NaN											0	0	0	1	0	48	87									
FAT3	120114	broad.mit.edu	37	11	92531924	92531924	+	Silent	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr11:92531924C>T	uc001pdj.3	+	9	5762	c.5745C>T	c.(5743-5745)CCC>CCT	p.P1915P		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1915	Cadherin 17.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CTGAGGTACCCCCTGAACTGA	0.418		NaN								TCGA Ovarian(4;0.039)			0	0	0	1	0	25	3									
BUD13	84811	broad.mit.edu	37	11	116633513	116633513	+	Silent	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr11:116633513G>A	uc001ppn.2	-	4	826	c.792C>T	c.(790-792)CTC>CTT	p.L264L	BUD13_uc001ppo.2_Intron|BUD13_uc009yzc.2_Silent_p.L264L	NM_032725	NP_116114	Q9BRD0	BUD13_HUMAN	BUD13 homolog isoform 1	264	Arg-rich.									large_intestine(1)|pancreas(1)	2	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		GGGCCCTTCTGAGTTGCTGTG	0.517		NaN											0	0	0	1	0	140	14									
GRIN2B	2904	broad.mit.edu	37	12	13716716	13716716	+	Silent	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr12:13716716G>A	uc001rbt.2	-	13	3635	c.3456C>T	c.(3454-3456)ACC>ACT	p.T1152T		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	1152	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGTAGATGTCGGTCAGGTCTA	0.577		NaN											0	0	0	1	0	66	33									
MCRS1	10445	broad.mit.edu	37	12	49957275	49957275	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr12:49957275C>G	uc001ruk.1	-	7	803	c.612G>C	c.(610-612)CAG>CAC	p.Q204H	MCRS1_uc001rui.1_Missense_Mutation_p.Q217H|MCRS1_uc001ruj.1_Missense_Mutation_p.Q191H|MCRS1_uc001rul.1_Missense_Mutation_p.Q204H|MCRS1_uc009zlj.1_Missense_Mutation_p.Q13H|MCRS1_uc001rum.1_Missense_Mutation_p.Q191H|MCRS1_uc001run.1_Missense_Mutation_p.Q204H	NM_006337	NP_006328	Q96EZ8	MCRS1_HUMAN	microspherule protein 1 isoform 1	204					DNA recombination|DNA repair|protein modification process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|MLL1 complex|nucleolus	protein binding			large_intestine(1)	1						GGGCCTTGCTCTGGATGGCTG	0.597		NaN											0	0	0	1	0	6	13									
KIF5A	3798	broad.mit.edu	37	12	57963097	57963097	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr12:57963097G>A	uc001sor.1	+	10	1086	c.878G>A	c.(877-879)GGG>GAG	p.G293E	KIF5A_uc010srr.1_Missense_Mutation_p.G204E	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	kinesin family member 5A	293	Kinesin-motor.|Microtubule-binding.				blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3						GACTCTCTCGGGGGAAACTGC	0.478		NaN											0	0	0	1	0	22	71									
MYF5	4617	broad.mit.edu	37	12	81110945	81110945	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr12:81110945C>T	uc001szg.2	+	1	238	c.103C>T	c.(103-105)CGA>TGA	p.R35*		NM_005593	NP_005584	P13349	MYF5_HUMAN	myogenic factor 5	35					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						GTTTGTGCCGCGAGTGGCTGC	0.622		NaN											0	0	0	1	0	46	19									
TRPV4	59341	broad.mit.edu	37	12	110238434	110238434	+	Missense_Mutation	SNP	T	T	C			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr12:110238434T>C	uc001tpj.1	-	4	937	c.842A>G	c.(841-843)TAC>TGC	p.Y281C	TRPV4_uc001tpg.1_Missense_Mutation_p.Y247C|TRPV4_uc001tph.1_Intron|TRPV4_uc001tpi.1_Intron|TRPV4_uc001tpk.1_Missense_Mutation_p.Y281C|TRPV4_uc001tpl.1_Missense_Mutation_p.Y281C	NM_021625	NP_067638	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel,	281	Cytoplasmic (Potential).				actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						AAAGTAGAAGTAGCCCCCCTC	0.612		NaN											0	0	0	1	0	61	28									
SACS	26278	broad.mit.edu	37	13	23908464	23908464	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr13:23908464C>T	uc001uon.2	-	10	10140	c.9551G>A	c.(9550-9552)CGC>CAC	p.R3184H	SACS_uc001uoo.2_Missense_Mutation_p.R3037H|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	3184					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CAAGTCTTTGCGGGATGGAAT	0.343		NaN											0	0	0	1	0	11	13									
PABPC3	5042	broad.mit.edu	37	13	25671775	25671775	+	Nonsense_Mutation	SNP	C	C	G			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr13:25671775C>G	uc001upy.2	+	1	1500	c.1439C>G	c.(1438-1440)TCA>TGA	p.S480*		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	480					mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		GCTAACACATCAACACAGACA	0.433		NaN											0	0	0	1	0	31	55									
FLT1	2321	broad.mit.edu	37	13	29012388	29012388	+	Silent	SNP	C	C	T	rs116486684	by1000genomes	TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr13:29012388C>T	uc001usb.3	-	4	768	c.483G>A	c.(481-483)ACG>ACA	p.T161T	FLT1_uc010aar.1_Silent_p.T161T|FLT1_uc001usc.3_Silent_p.T161T|FLT1_uc010tdp.1_Silent_p.T161T	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	161	Ig-like C2-type 2.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TGTTAGGTGACGTAACCCGGC	0.398		NaN											0	0	0	1	0	11	11									
HS6ST3	266722	broad.mit.edu	37	13	96743176	96743176	+	Silent	SNP	C	C	G			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr13:96743176C>G	uc001vmw.2	+	1	84	c.60C>G	c.(58-60)GTC>GTG	p.V20V		NM_153456	NP_703157	Q8IZP7	H6ST3_HUMAN	heparan sulfate 6-O-sulfotransferase 3	20	Helical; Signal-anchor for type II membrane protein; (Potential).					integral to membrane	sulfotransferase activity			ovary(1)|skin(1)	2	all_neural(89;0.0878)|Medulloblastoma(90;0.163)					TCTTCGTGGTCATCATGTACC	0.438		NaN											0	0	0	1	0	16	27									
COL4A2	1284	broad.mit.edu	37	13	111164350	111164350	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr13:111164350C>T	uc001vqx.2	+	48	5240	c.4951C>T	c.(4951-4953)CGC>TGC	p.R1651C		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	1651	Collagen IV NC1.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			AGAGGACTTCCGCGCCACACC	0.617		NaN											0	0	0	1	0	34	74									
OR6S1	341799	broad.mit.edu	37	14	21108981	21108981	+	Silent	SNP	T	T	C			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr14:21108981T>C	uc001vxv.1	-	1	870	c.870A>G	c.(868-870)CCA>CCG	p.P290P		NM_001001968	NP_001001968	Q8NH40	OR6S1_HUMAN	olfactory receptor, family 6, subfamily S,	290	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00304)		Epithelial(56;1.23e-06)|all cancers(55;1.01e-05)	GBM - Glioblastoma multiforme(265;0.0135)		CATAGATGAATGGATTCAACA	0.433		NaN											0	0	0	1	0	78	102									
FBXO34	55030	broad.mit.edu	37	14	55817949	55817949	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr14:55817949G>C	uc001xbu.2	+	2	1086	c.841G>C	c.(841-843)GAC>CAC	p.D281H	FBXO34_uc001xbv.2_RNA|FBXO34_uc010aoo.2_Missense_Mutation_p.D281H	NM_017943	NP_060413	Q9NWN3	FBX34_HUMAN	F-box only protein 34	281										ovary(2)|lung(2)|skin(1)	5						CCGTGTCCTTGACATGGTAGC	0.552		NaN											0	0	0	1	0	88	81									
ATP10A	57194	broad.mit.edu	37	15	25969114	25969114	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr15:25969114G>A	uc010ayu.2	-	6	1140	c.1034C>T	c.(1033-1035)CCC>CTC	p.P345L		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	345	Extracellular (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		ATCAGACTTGGGGACATAAAA	0.373		NaN											0	0	0	1	0	44	74									
GABRA5	2558	broad.mit.edu	37	15	27126006	27126006	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr15:27126006C>T	uc001zbd.1	+	5	439	c.100C>T	c.(100-102)CCA>TCA	p.P34S	GABRB3_uc001zbb.2_Intron	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	34	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TTCACAGATGCCAACCAGTTC	0.418		NaN											0	0	0	1	0	21	39									
RFX7	64864	broad.mit.edu	37	15	56388173	56388173	+	Missense_Mutation	SNP	C	C	T	rs140370063	by1000genomes	TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr15:56388173C>T	uc010bfn.2	-	9	1753	c.1753G>A	c.(1753-1755)GAA>AAA	p.E585K	RFX7_uc010ugk.1_RNA|RFX7_uc002adn.1_Missense_Mutation_p.E399K	NM_022841	NP_073752	Q2KHR2	RFX7_HUMAN	regulatory factor X domain containing 2	488					regulation of transcription, DNA-dependent	nucleus	DNA binding				0						ATGACACCTTCATTTGAAGGT	0.458		NaN											0	0	0	1	0	21	14									
C15orf27	123591	broad.mit.edu	37	15	76496330	76496330	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr15:76496330C>T	uc002bbq.2	+	11	1425	c.1270C>T	c.(1270-1272)CCT>TCT	p.P424S	C15orf27_uc010bkp.2_Missense_Mutation_p.P240S|C15orf27_uc002bbr.2_Missense_Mutation_p.P240S|C15orf27_uc002bbs.2_Missense_Mutation_p.P102S	NM_152335	NP_689548	Q2M3C6	CO027_HUMAN	hypothetical protein LOC123591	424						integral to membrane					0						TGAGCCCGGCCCTTCTCCCCC	0.701		NaN											0	0	0	1	0	28	38									
MKL2	57496	broad.mit.edu	37	16	14339510	14339510	+	Missense_Mutation	SNP	A	A	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr16:14339510A>T	uc010uza.1	+	11	1360	c.1205A>T	c.(1204-1206)GAC>GTC	p.D402V	MKL2_uc002dcg.2_Missense_Mutation_p.D402V|MKL2_uc002dcj.2_5'Flank	NM_014048	NP_054767	Q9ULH7	MKL2_HUMAN	megakaryoblastic leukemia 2 protein	391	SAP.				cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			ovary(3)|kidney(1)|pancreas(1)	5						AGCCTGGATGACTTAAAGGTG	0.433		NaN											0	0	0	1	0	61	94									
SLC9A5	6553	broad.mit.edu	37	16	67289057	67289057	+	Silent	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr16:67289057C>T	uc002esm.2	+	3	687	c.624C>T	c.(622-624)GGC>GGT	p.G208G	SLC9A5_uc010cee.2_5'UTR|SLC9A5_uc010vji.1_5'UTR	NM_004594	NP_004585	Q14940	SL9A5_HUMAN	solute carrier family 9 (sodium/hydrogen	208	Helical; (Potential).				regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			ovary(1)|pancreas(1)	2		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		TCGTCTTTGGCGAGTCCCTGC	0.592		NaN											0	0	0	1	0	67	72									
MYH1	4619	broad.mit.edu	37	17	10398335	10398335	+	Silent	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr17:10398335C>T	uc002gmo.2	-	37	5473	c.5379G>A	c.(5377-5379)ACG>ACA	p.T1793T	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1793	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						GGTCCTTCACCGTCTGTTCCA	0.557		NaN											0	0	0	1	0	119	12									
ALKBH5	54890	broad.mit.edu	37	17	18088053	18088053	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr17:18088053G>A	uc010cpw.2	+	1	1187	c.496G>A	c.(496-498)GAG>AAG	p.E166K	uc002gsn.2_RNA|ALKBH5_uc010cpx.2_5'Flank	NM_017758	NP_060228	Q6P6C2	ALKB5_HUMAN	alkB, alkylation repair homolog 5	166						integral to membrane	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0	all_neural(463;0.228)					CGAGATCCCCGAGTGGGTGCA	0.672		NaN											0	0	0	1	0	45	3									
GPR179	440435	broad.mit.edu	37	17	36492872	36492872	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr17:36492872G>A	uc002hpz.2	-	4	1237	c.1216C>T	c.(1216-1218)CGC>TGC	p.R406C		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	406	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				TTGTTCCGGCGGCAGCGGTAG	0.577		NaN											0	0	0	1	0	9	11									
GSDMA	284110	broad.mit.edu	37	17	38133155	38133155	+	Silent	SNP	C	C	T	rs138595723	by1000genomes	TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr17:38133155C>T	uc002htl.1	+	12	1300	c.1182C>T	c.(1180-1182)GAC>GAT	p.D394D	GSDMA_uc002htm.1_Silent_p.D394D	NM_178171	NP_835465	Q96QA5	GSDMA_HUMAN	gasdermin 1	394					apoptosis|induction of apoptosis	perinuclear region of cytoplasm					0						CCCTTGGGGACGAGGAGCTGA	0.597		NaN											0	0	0	1	0	24	104									
PTRF	284119	broad.mit.edu	37	17	40556892	40556892	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr17:40556892C>T	uc002hzo.2	-	2	1145	c.986G>A	c.(985-987)CGC>CAC	p.R329H	PTRF_uc010wgi.1_Missense_Mutation_p.R311H	NM_012232	NP_036364	Q6NZI2	PTRF_HUMAN	polymerase I and transcript release factor	329					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription initiation from RNA polymerase I promoter	caveola|cytosol|endoplasmic reticulum|microsome|mitochondrion|nucleoplasm	protein binding|rRNA primary transcript binding			breast(1)	1		all_cancers(22;0.00146)|Breast(137;0.00116)|all_epithelial(22;0.0134)		BRCA - Breast invasive adenocarcinoma(366;0.193)		CTGGCCCTCGCGGATCTTCTT	0.677		NaN											0	0	0	1	0	24	66									
CDC27	996	broad.mit.edu	37	17	45247383	45247383	+	Missense_Mutation	SNP	A	A	C			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr17:45247383A>C	uc002ild.3	-	4	404	c.277T>G	c.(277-279)TCT>GCT	p.S93A	CDC27_uc002ile.3_Missense_Mutation_p.S93A|CDC27_uc002ilf.3_Missense_Mutation_p.S93A|CDC27_uc010wkp.1_Missense_Mutation_p.S32A|CDC27_uc010wkq.1_RNA	NM_001256	NP_001247	P30260	CDC27_HUMAN	cell division cycle protein 27 isoform 2	93	TPR 1.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			lung(2)|breast(2)|ovary(1)	5						ACTCCACCAGATAAGATTTGT	0.313		NaN											0	0	0	1	0	8	142									
CDK5RAP3	80279	broad.mit.edu	37	17	46053301	46053301	+	Silent	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr17:46053301G>A	uc002imr.2	+	8	804	c.720G>A	c.(718-720)GAG>GAA	p.E240E	CDK5RAP3_uc010wlc.1_Silent_p.E260E|CDK5RAP3_uc002imq.1_Silent_p.E15E|CDK5RAP3_uc002imu.2_Silent_p.E84E|CDK5RAP3_uc002ims.2_Silent_p.E153E|CDK5RAP3_uc002imv.2_Silent_p.E84E|CDK5RAP3_uc002imw.2_Silent_p.E84E|CDK5RAP3_uc002imx.2_Silent_p.E15E	NM_176096	NP_788276	Q96JB5	CK5P3_HUMAN	CDK5 regulatory subunit associated protein 3	240					brain development|regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation		neuronal Cdc2-like kinase binding				0						CGGTGTACGAGTGGAGGACAG	0.587		NaN											0	0	0	1	0	46	84									
TRIM25	7706	broad.mit.edu	37	17	54969173	54969173	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr17:54969173G>T	uc002iut.2	-	9	1841	c.1781C>A	c.(1780-1782)GCC>GAC	p.A594D	TRIM25_uc010dcj.2_Missense_Mutation_p.A386D	NM_005082	NP_005073	Q14258	TRI25_HUMAN	tripartite motif-containing 25	594	B30.2/SPRY.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|response to virus	cell junction|cytosol|nucleus	sequence-specific DNA binding transcription factor activity|ubiquitin-protein ligase activity|zinc ion binding			lung(1)|breast(1)|skin(1)	3	Breast(9;6.15e-08)					GACCTTGTCGGCAACAGCGAA	0.542		NaN											1	0	4.4004e-07	1	4.45217e-07	25	28									
LPO	4025	broad.mit.edu	37	17	56321382	56321382	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr17:56321382C>G	uc002ivt.2	+	3	420	c.104C>G	c.(103-105)TCC>TGC	p.S35C	LPO_uc010dco.2_Missense_Mutation_p.S35C|LPO_uc010wnr.1_Intron|LPO_uc010wns.1_Intron|LPO_uc010dcp.2_Intron	NM_006151	NP_006142	P22079	PERL_HUMAN	lactoperoxidase isoform 1 preproprotein	35					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|breast(1)	2						TCTGCCATCTCCGATACTGTG	0.468		NaN											0	0	0	1	0	11	32									
LPO	4025	broad.mit.edu	37	17	56342246	56342246	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr17:56342246G>A	uc002ivt.2	+	10	1746	c.1430G>A	c.(1429-1431)CGC>CAC	p.R477H	LPO_uc010wns.1_Missense_Mutation_p.R418H|LPO_uc010dcp.2_Missense_Mutation_p.R394H|LPO_uc010dcq.2_Missense_Mutation_p.R148H|LPO_uc010dcr.2_Missense_Mutation_p.R40H	NM_006151	NP_006142	P22079	PERL_HUMAN	lactoperoxidase isoform 1 preproprotein	477					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|breast(1)	2						AGTATGTTCCGCCTGGATGAG	0.512		NaN											0	0	0	1	0	32	43									
GPR142	350383	broad.mit.edu	37	17	72368159	72368159	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr17:72368159C>T	uc010wqy.1	+	4	809	c.809C>T	c.(808-810)TCG>TTG	p.S270L	GPR142_uc010wqx.1_Missense_Mutation_p.S182L	NM_181790	NP_861455	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	270	Cytoplasmic (Potential).					cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						CGGGCCGCCTCGTCCCCAGGC	0.657		NaN											0	0	0	1	0	23	22									
PRTN3	5657	broad.mit.edu	37	19	846267	846267	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr19:846267G>A	uc002lqa.1	+	4	514	c.490G>A	c.(490-492)GAC>AAC	p.D164N		NM_002777	NP_002768	P24158	PRTN3_HUMAN	myeloblastin	164	Peptidase S1.				collagen catabolic process|positive regulation of cell proliferation|proteolysis		protein binding|serine-type endopeptidase activity			ovary(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGTGCCCACGACCCCCCAGC	0.677		NaN											0	0	0	1	0	8	8									
PTPRS	5802	broad.mit.edu	37	19	5212395	5212395	+	Silent	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr19:5212395G>A	uc002mbv.2	-	31	4956	c.4722C>T	c.(4720-4722)GTC>GTT	p.V1574V	PTPRS_uc002mbu.1_Silent_p.V1143V|PTPRS_uc010xin.1_Silent_p.V1116V|PTPRS_uc002mbw.2_Silent_p.V1536V|PTPRS_uc002mbx.2_Silent_p.V1131V|PTPRS_uc002mby.2_Silent_p.V1127V	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	1574	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		TGCAGGTCTTGACTCTCCGCA	0.662		NaN											0	0	0	1	0	6	27									
MUC16	94025	broad.mit.edu	37	19	9076790	9076790	+	Silent	SNP	A	A	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr19:9076790A>T	uc002mkp.2	-	3	10860	c.10656T>A	c.(10654-10656)ACT>ACA	p.T3552T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3553	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGGTGTGGTAGTTGAGATTG	0.547		NaN											0	0	0	1	0	90	131									
CACNA1A	773	broad.mit.edu	37	19	13409644	13409644	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr19:13409644G>A	uc010dze.2	-	19	3042	c.2806C>T	c.(2806-2808)CGG>TGG	p.R936W	CACNA1A_uc010dzc.2_Missense_Mutation_p.R461W|CACNA1A_uc002mwy.3_Missense_Mutation_p.R935W|CACNA1A_uc010xne.1_Missense_Mutation_p.R464W	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	936	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CCCCCCTGCCGGTGCACGTGC	0.731		NaN											0	0	0	1	0	16	20									
ZNF257	113835	broad.mit.edu	37	19	22272043	22272043	+	Silent	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr19:22272043C>T	uc010ecx.2	+	4	1660	c.1491C>T	c.(1489-1491)AAC>AAT	p.N497N	ZNF257_uc010ecy.2_Silent_p.N465N	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	497	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				AAGCCTTTAACCGGTCTTCAC	0.393		NaN											0	0	0	1	0	32	35									
ZNF792	126375	broad.mit.edu	37	19	35451871	35451871	+	Missense_Mutation	SNP	T	T	C			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr19:35451871T>C	uc002nxh.1	-	2	448	c.61A>G	c.(61-63)ATT>GTT	p.I21V		NM_175872	NP_787068	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	21	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GAGAAGTAAATGGTCACGTCC	0.547		NaN											0	0	0	1	0	76	102									
HPN	3249	broad.mit.edu	37	19	35551678	35551678	+	Silent	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr19:35551678C>T	uc002nxq.1	+	10	1013	c.768C>T	c.(766-768)AAC>AAT	p.N256N	HPN_uc002nxr.1_Silent_p.N256N|HPN_uc002nxs.1_Silent_p.N98N|HPN_uc010xsh.1_Silent_p.N225N|HPN_uc002nxt.1_Silent_p.N140N|LOC100128675_uc010xsi.1_Intron	NM_002151	NP_002142	P05981	HEPS_HUMAN	hepsin	256	Extracellular (Potential).|Peptidase S1.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(1)|central_nervous_system(1)	2	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	AGAACAGCAACGATATTGCCC	0.637		NaN											0	0	0	1	0	19	105									
TIMM50	92609	broad.mit.edu	37	19	39971574	39971574	+	Silent	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr19:39971574G>A	uc002olu.1	+	1	523	c.390G>A	c.(388-390)GCG>GCA	p.A130A	TIMM50_uc002olt.1_RNA	NM_001001563	NP_001001563	Q3ZCQ8	TIM50_HUMAN	translocase of inner mitochondrial membrane 50	27					mitochondrial membrane organization|protein transport|release of cytochrome c from mitochondria|transmembrane transport	integral to membrane|mitochondrial inner membrane presequence translocase complex|nuclear speck	interleukin-2 receptor binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|ribonucleoprotein binding|RNA binding			ovary(1)	1	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CGAGGTTGGCGACGCCGCCCC	0.706		NaN											0	0	0	1	0	9	23									
MARK4	57787	broad.mit.edu	37	19	45783636	45783636	+	Silent	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr19:45783636G>A	uc002pbb.1	+	11	1016	c.1011G>A	c.(1009-1011)GTG>GTA	p.V337V	MARK4_uc002paz.1_Missense_Mutation_p.D75N|MARK4_uc002pba.1_Silent_p.V337V|MARK4_uc002pbc.1_Silent_p.V203V			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	337	UBA.				microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TCCCAGAGGTGATGGTGGGTA	0.428		NaN											0	0	0	1	0	115	148									
ZNF649	65251	broad.mit.edu	37	19	52394437	52394437	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr19:52394437G>C	uc002pxy.2	-	5	1220	c.952C>G	c.(952-954)CAT>GAT	p.H318D	ZNF577_uc010ydf.1_5'Flank	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	zinc finger protein 649	318	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		CTGCATGTATGAGGCTTCTCT	0.453		NaN											0	0	0	1	0	27	37									
BRSK1	84446	broad.mit.edu	37	19	55815073	55815073	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr19:55815073C>T	uc002qkg.2	+	12	1442	c.1165C>T	c.(1165-1167)CGT>TGT	p.R389C	BRSK1_uc002qkf.2_Missense_Mutation_p.R405C|BRSK1_uc002qkh.2_Missense_Mutation_p.R84C	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	389					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		CATGCTGAGCCGTCACGGGAA	0.582		NaN											0	0	0	1	0	61	82									
LPIN1	23175	broad.mit.edu	37	2	11911614	11911614	+	Silent	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr2:11911614G>A	uc010yjn.1	+	5	679	c.405G>A	c.(403-405)ACG>ACA	p.T135T	LPIN1_uc010yjm.1_Silent_p.T184T|LPIN1_uc002rbt.2_Silent_p.T135T|LPIN1_uc002rbs.2_Silent_p.T135T	NM_145693	NP_663731	Q14693	LPIN1_HUMAN	lipin 1	135					fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		ACCCCAGCACGCCAGCCCAAG	0.567		NaN											0	0	0	1	0	12	61									
GFPT1	2673	broad.mit.edu	37	2	69575328	69575328	+	Silent	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr2:69575328C>T	uc002sfh.2	-	10	1109	c.930G>A	c.(928-930)CAG>CAA	p.Q310Q		NM_002056	NP_002047	Q06210	GFPT1_HUMAN	glucosamine-fructose-6-phosphate	328					dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			skin(1)	1						GGAGTTCCATCTGGAGTGTTT	0.428		NaN											0	0	0	1	0	75	73									
ANKRD36	375248	broad.mit.edu	37	2	97779652	97779652	+	Missense_Mutation	SNP	A	A	G			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr2:97779652A>G	uc010yva.1	+	1	420	c.176A>G	c.(175-177)AAT>AGT	p.N59S	ANKRD36_uc002sxn.2_Missense_Mutation_p.N59S|ANKRD36_uc010yuz.1_RNA|ANKRD36_uc010fic.2_5'UTR|ANKRD36_uc002sxo.2_Missense_Mutation_p.N59S|ANKRD36_uc002sxp.3_RNA	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	59	ANK 1.										0						TATGACGCCAATAAGAGAGAC	0.527		NaN											0	0	0	1	0	30	27									
MYO7B	4648	broad.mit.edu	37	2	128380819	128380819	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr2:128380819G>A	uc002top.2	+	28	3663	c.3610G>A	c.(3610-3612)GCC>ACC	p.A1204T	MYO7B_uc002toq.1_Missense_Mutation_p.A57T|MYO7B_uc002tor.1_Missense_Mutation_p.A57T	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1204	FERM 1.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		AGTCATCTTGGCCACTGGAGA	0.577		NaN											0	0	0	1	0	12	43									
XIRP2	129446	broad.mit.edu	37	2	168104956	168104956	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr2:168104956G>A	uc002udx.2	+	8	7072	c.7054G>A	c.(7054-7056)GAT>AAT	p.D2352N	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.D2177N|XIRP2_uc010fpq.2_Missense_Mutation_p.D2130N|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2177	Pro-rich.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						ACCTCCAGTAGATGAGAAATC	0.473		NaN											0	0	0	1	0	47	131									
TTN	7273	broad.mit.edu	37	2	179579099	179579099	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr2:179579099G>A	uc010zfg.1	-	88	22894	c.22670C>T	c.(22669-22671)CCA>CTA	p.P7557L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P4218L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8484							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCATTGGCTGGTTCCACTCT	0.403		NaN											0	0	0	1	0	65	32									
FAM171B	165215	broad.mit.edu	37	2	187626350	187626350	+	Missense_Mutation	SNP	A	A	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr2:187626350A>T	uc002ups.2	+	8	1393	c.1281A>T	c.(1279-1281)TTA>TTT	p.L427F	FAM171B_uc002upr.1_Intron|FAM171B_uc002upt.2_5'Flank	NM_177454	NP_803237	Q6P995	F171B_HUMAN	KIAA1946	427	Cytoplasmic (Potential).					integral to membrane	DNA binding			ovary(6)|breast(3)|central_nervous_system(1)	10						AGTCGCAGTTATTCAATGCCA	0.383		NaN											0	0	0	1	0	52	46									
SF3B1	23451	broad.mit.edu	37	2	198281605	198281605	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr2:198281605C>T	uc002uue.2	-	6	574	c.526G>A	c.(526-528)GCT>ACT	p.A176T	SF3B1_uc010fsk.1_RNA	NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	176					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CCAGCTTTAGCTTTTTCTGCT	0.423		NaN											0	0	0	1	0	54	125									
SERINC3	10955	broad.mit.edu	37	20	43142655	43142655	+	Silent	SNP	T	T	C			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr20:43142655T>C	uc002xme.2	-	2	200	c.66A>G	c.(64-66)TCA>TCG	p.S22S	SERINC3_uc002xmf.1_Silent_p.S22S|SERINC3_uc010ggs.1_Silent_p.S15S|SERINC3_uc010zwp.1_5'UTR	NM_198941	NP_945179	Q13530	SERC3_HUMAN	tumor differentially expressed protein 1	22	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			skin(3)	3		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			ACAGCAAACATGAGGCACCGC	0.488		NaN											0	0	0	1	0	84	49									
LAMA5	3911	broad.mit.edu	37	20	60913289	60913289	+	Silent	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr20:60913289C>T	uc002ycq.2	-	13	1822	c.1755G>A	c.(1753-1755)CAG>CAA	p.Q585Q		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	585	Laminin EGF-like 5.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACCACTCACACTGGCAGAGAG	0.672		NaN											0	0	0	1	0	18	23									
RIPK4	54101	broad.mit.edu	37	21	43176836	43176836	+	Missense_Mutation	SNP	A	A	C			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr21:43176836A>C	uc002yzn.1	-	2	371	c.323T>G	c.(322-324)CTG>CGG	p.L108R		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	108						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						CTCCGAAGCCAGCAGCTTTTC	0.602		NaN											0	0	0	1	0	49	50									
PCBP3	54039	broad.mit.edu	37	21	47349884	47349884	+	Silent	SNP	C	C	G			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr21:47349884C>G	uc002zhq.1	+	10	896	c.771C>G	c.(769-771)CTC>CTG	p.L257L	PCBP3_uc010gqb.2_Silent_p.L257L|PCBP3_uc002zhp.1_Silent_p.L257L|PCBP3_uc002zhs.1_Silent_p.L231L|PCBP3_uc002zhr.1_Silent_p.L256L|PCBP3_uc002zht.1_Silent_p.L247L	NM_020528	NP_065389	P57721	PCBP3_HUMAN	poly(rC) binding protein 3 isoform 1	257					mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			skin(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		TTCCTCCCCTCGGACAGACCA	0.552		NaN											0	0	0	1	0	60	105									
SNAP29	9342	broad.mit.edu	37	22	21213484	21213484	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr22:21213484G>A	uc011ahw.1	+	1	193	c.86G>A	c.(85-87)CGA>CAA	p.R29Q	PI4KA_uc002zsz.3_5'Flank|PI4KA_uc010gsq.1_5'Flank	NM_004782	NP_004773	O95721	SNP29_HUMAN	synaptosomal-associated protein 29	29					cellular membrane fusion|exocytosis|protein transport|vesicle targeting	cell junction|cytoplasm|nucleus|synapse|synaptosome	SNAP receptor activity				0	all_cancers(11;2.77e-25)|all_epithelial(7;8.92e-24)|Lung NSC(8;1.49e-15)|all_lung(8;2.54e-14)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000592)|Lung(15;0.0117)			AGGGACGCCCGAGACCTCCCC	0.716		NaN											0	0	0	1	0	10	28									
CHEK2	11200	broad.mit.edu	37	22	29091840	29091841	+	Missense_Mutation	DNP	TG	TG	CA	rs142470496	byFrequency	TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr22:29091840_29091841TG>CA	uc003adu.1	-	11	1188_1189	c.1116_1117CA>TG	c.(1114-1119)TCCAAG>TCTGAG	p.K373E	CHEK2_uc003ads.1_Missense_Mutation_p.K152E|CHEK2_uc010gvh.1_Missense_Mutation_p.K282E|CHEK2_uc010gvi.1_Intron|CHEK2_uc010gvj.1_Intron|CHEK2_uc003adr.1_RNA|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Missense_Mutation_p.K416E|CHEK2_uc003adv.1_Missense_Mutation_p.K344E|CHEK2_uc003adw.1_Missense_Mutation_p.K373E|CHEK2_uc003adx.1_Missense_Mutation_p.K152E|CHEK2_uc003ady.1_Missense_Mutation_p.K373E|CHEK2_uc003adz.1_Missense_Mutation_p.K177E	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	373	Protein kinase.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(2)|p.S372S(1)		central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						CCCAAAATCTTGGAGTGCCCAA	0.416		NaN	F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer				0	0	0	1	0	5	76									
ANKRD28	23243	broad.mit.edu	37	3	15752761	15752761	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr3:15752761C>T	uc003caj.1	-	12	1347	c.1204G>A	c.(1204-1206)GAT>AAT	p.D402N	ANKRD28_uc003cai.1_Missense_Mutation_p.D248N|ANKRD28_uc011avz.1_Missense_Mutation_p.D248N|ANKRD28_uc003cak.1_RNA|ANKRD28_uc011awa.1_RNA|ANKRD28_uc003cal.1_Missense_Mutation_p.D432N|ANKRD28_uc003cam.2_Missense_Mutation_p.D435N	NM_015199	NP_056014	O15084	ANR28_HUMAN	ankyrin repeat domain 28	402						nucleoplasm	protein binding			breast(1)	1						CCAAAATCATCTGGGGTATCT	0.328		NaN											0	0	0	1	0	51	6									
MST1R	4486	broad.mit.edu	37	3	49927946	49927946	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr3:49927946G>A	uc003cxy.3	-	18	4046	c.3782C>T	c.(3781-3783)ACC>ATC	p.T1261I	MST1R_uc011bdc.1_Missense_Mutation_p.T140I	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	1261	Cytoplasmic (Potential).|Protein kinase.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		AAATCTATAGGTCTGCAGGCT	0.572		NaN											0	0	0	1	0	36	2									
MST1R	4486	broad.mit.edu	37	3	49928679	49928679	+	Silent	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr3:49928679G>A	uc003cxy.3	-	17	3859	c.3595C>T	c.(3595-3597)CTG>TTG	p.L1199L	MST1R_uc011bdc.1_Silent_p.L78L	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	1199	Cytoplasmic (Potential).|Protein kinase.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		TGCTCTGCCAGGTACTCCATG	0.612		NaN											0	0	0	1	0	63	2									
MST1R	4486	broad.mit.edu	37	3	49928719	49928719	+	Silent	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr3:49928719G>A	uc003cxy.3	-	17	3819	c.3555C>T	c.(3553-3555)CTC>CTT	p.L1185L	MST1R_uc011bdc.1_Silent_p.L64L	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	1185	Cytoplasmic (Potential).|Protein kinase.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		CAAAGCTGATGAGGTCCTTCA	0.632		NaN											0	0	0	1	0	64	4									
MST1R	4486	broad.mit.edu	37	3	49929255	49929255	+	Silent	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr3:49929255G>A	uc003cxy.3	-	15	3552	c.3288C>T	c.(3286-3288)GTC>GTT	p.V1096V	MST1R_uc011bdc.1_5'UTR	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	1096	Cytoplasmic (Potential).|ATP.|Protein kinase.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		CTCCGTGGTAGACAACTCCAA	0.532		NaN											0	0	0	1	0	129	11									
MBD4	8930	broad.mit.edu	37	3	129150350	129150350	+	Silent	SNP	T	T	C			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr3:129150350T>C	uc003emh.1	-	8	1913	c.1737A>G	c.(1735-1737)CTA>CTG	p.L579L	uc003emg.2_5'Flank|MBD4_uc003emi.1_3'UTR|MBD4_uc003emj.1_Silent_p.L573L|MBD4_uc003emk.1_Silent_p.L261L	NM_003925	NP_003916	O95243	MBD4_HUMAN	methyl-CpG binding domain protein 4	579					depyrimidination	nucleoplasm	DNA N-glycosylase activity|endodeoxyribonuclease activity|protein binding|satellite DNA binding			ovary(1)|lung(1)	2						GAGTTTAAGATAGACTTAATT	0.368		NaN						BER_DNA_glycosylases					0	0	0	1	0	125	9									
FGFR3	2261	broad.mit.edu	37	4	1803568	1803568	+	Missense_Mutation	SNP	C	C	G	rs121913483		TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr4:1803568C>G	uc003gdr.3	+	7	1002	c.746C>G	c.(745-747)TCC>TGC	p.S249C	FGFR3_uc003gdu.2_Missense_Mutation_p.S249C|FGFR3_uc003gds.3_Missense_Mutation_p.S249C|FGFR3_uc003gdq.3_Missense_Mutation_p.S249C|FGFR3_uc010icb.1_Missense_Mutation_p.S91C|FGFR3_uc003gdt.1_Missense_Mutation_p.S91C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	249	Extracellular (Potential).		S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1368)|p.R248_S249insC(2)|p.S249T(1)|p.R248_S249del(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.562		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	1	0	20	11									
TBC1D1	23216	broad.mit.edu	37	4	38051478	38051478	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr4:38051478G>C	uc003gtb.2	+	11	2212	c.1869G>C	c.(1867-1869)ATG>ATC	p.M623I	TBC1D1_uc011byd.1_Missense_Mutation_p.M623I|TBC1D1_uc010ifd.2_Missense_Mutation_p.M370I|TBC1D1_uc011byf.1_Missense_Mutation_p.M494I	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	623						nucleus	Rab GTPase activator activity			ovary(1)	1						GGAAACTTATGAGGTATCACT	0.507		NaN											0	0	0	1	0	124	56									
FRAS1	80144	broad.mit.edu	37	4	79205678	79205678	+	Missense_Mutation	SNP	T	T	C			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr4:79205678T>C	uc003hlb.2	+	13	1815	c.1375T>C	c.(1375-1377)TAC>CAC	p.Y459H	FRAS1_uc003hkw.2_Missense_Mutation_p.Y459H|FRAS1_uc003hky.1_Missense_Mutation_p.Y163H|FRAS1_uc003hkz.2_Missense_Mutation_p.Y163H|FRAS1_uc003hla.1_5'Flank	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	459	FU 1.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						ACTGGGTTTTTACCAAGCTGG	0.488		NaN											0	0	0	1	0	53	82									
PDHA2	5161	broad.mit.edu	37	4	96761293	96761293	+	Translation_Start_Site	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr4:96761293G>A	uc003htr.3	+	1	55	c.-8G>A	c.(-10--6)CCGTG>CCATG			NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor						glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	ACAGCACTCCGTGAAGAATAT	0.617		NaN											0	0	0	1	0	4	16									
MTTP	4547	broad.mit.edu	37	4	100532349	100532349	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr4:100532349C>T	uc003hvc.3	+	14	2075	c.1819C>T	c.(1819-1821)CGT>TGT	p.R607C	MTTP_uc011cej.1_Missense_Mutation_p.R634C	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	607	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	CAATTATGACCGTTTCTCCAG	0.423		NaN											0	0	0	1	0	26	46									
FGG	2266	broad.mit.edu	37	4	155527888	155527888	+	Silent	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr4:155527888G>A	uc003ioj.2	-	8	1239	c.1098C>T	c.(1096-1098)CAC>CAT	p.H366H	FGG_uc003iog.2_Silent_p.H366H|FGG_uc003ioh.2_Silent_p.H374H|FGG_uc010ipx.2_Silent_p.H194H|FGG_uc010ipy.2_Silent_p.H77H|FGG_uc003ioi.2_Silent_p.H77H|FGG_uc003iok.2_Silent_p.H374H	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	366	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	GATGGCCAGCGTGACACTTGT	0.363		NaN											0	0	0	1	0	29	36									
ACSL1	2180	broad.mit.edu	37	4	185684329	185684329	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr4:185684329C>T	uc003iww.2	-	16	1807	c.1513G>A	c.(1513-1515)GAG>AAG	p.E505K	ACSL1_uc011ckm.1_Missense_Mutation_p.E334K|ACSL1_uc003iwt.1_Missense_Mutation_p.E505K|ACSL1_uc003iwu.1_Missense_Mutation_p.E505K|ACSL1_uc011ckn.1_Missense_Mutation_p.E471K|ACSL1_uc003iws.1_Missense_Mutation_p.E75K	NM_001995	NP_001986	P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	505	Cytoplasmic (Potential).				digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			ovary(2)	2		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	ACCTCGCCCTCGCCCTCGGCA	0.478		NaN											0	0	0	1	0	8	21									
DNAH5	1767	broad.mit.edu	37	5	13753602	13753602	+	Missense_Mutation	SNP	A	A	C			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr5:13753602A>C	uc003jfd.2	-	63	10654	c.10612T>G	c.(10612-10614)TTT>GTT	p.F3538V	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3538					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AGATCACGAAACTCTTGGTTA	0.383		NaN							Kartagener_syndrome				0	0	0	1	0	33	95									
NLN	57486	broad.mit.edu	37	5	65118647	65118647	+	Silent	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr5:65118647G>A	uc003juf.2	+	13	2135	c.2019G>A	c.(2017-2019)GGG>GGA	p.G673G	NLN_uc003jug.2_Silent_p.G502G|NLN_uc010iww.2_Silent_p.G350G	NM_020726	NP_065777	Q9BYT8	NEUL_HUMAN	neurolysin precursor	673					proteolysis	mitochondrial intermembrane space	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0743)|Lung(70;0.00616)		TGAAACCTGGGGGATCTCTGG	0.408		NaN											0	0	0	1	0	28	67									
SLC30A5	64924	broad.mit.edu	37	5	68404192	68404192	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr5:68404192G>C	uc003jvh.2	+	5	577	c.376G>C	c.(376-378)GAG>CAG	p.E126Q	SLC30A5_uc003jvi.2_5'UTR	NM_022902	NP_075053	Q8TAD4	ZNT5_HUMAN	solute carrier family 30 (zinc transporter),	126	Helical; (Potential).				cellular zinc ion homeostasis|cobalt ion transport|regulation of proton transport|response to zinc ion	apical plasma membrane|Golgi apparatus|integral to plasma membrane|membrane fraction|secretory granule membrane	zinc ion binding|zinc ion transmembrane transporter activity			central_nervous_system(1)	1		Lung NSC(167;0.000986)|Prostate(74;0.00809)|Colorectal(97;0.0508)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)		GCTGCTATTTGAGCACAGTGA	0.333		NaN											0	0	0	1	0	15	14									
FAM151B	167555	broad.mit.edu	37	5	79837636	79837636	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr5:79837636C>G	uc003kgv.1	+	6	959	c.816C>G	c.(814-816)ATC>ATG	p.I272M	FAM151B_uc010jal.1_RNA	NM_205548	NP_991111	Q6UXP7	F151B_HUMAN	hypothetical protein LOC167555	272											0		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;8.21e-47)|Epithelial(54;8.3e-42)|all cancers(79;1.97e-36)		CCATTGGAATCAAAGTTAATC	0.299		NaN											0	0	0	1	0	12	9									
FAM151B	167555	broad.mit.edu	37	5	79837648	79837648	+	Silent	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr5:79837648C>T	uc003kgv.1	+	6	971	c.828C>T	c.(826-828)CTC>CTT	p.L276L	FAM151B_uc010jal.1_RNA	NM_205548	NP_991111	Q6UXP7	F151B_HUMAN	hypothetical protein LOC167555	276											0		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;8.21e-47)|Epithelial(54;8.3e-42)|all cancers(79;1.97e-36)		AAGTTAATCTCTAAGAAGAAG	0.299		NaN											0	0	0	1	0	10	9									
GIN1	54826	broad.mit.edu	37	5	102442494	102442494	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr5:102442494C>T	uc003koa.1	-	3	341	c.259G>A	c.(259-261)GGT>AGT	p.G87S	GIN1_uc003kob.1_Intron|GIN1_uc003koc.1_Missense_Mutation_p.G87S	NM_017676	NP_060146	Q9NXP7	GIN1_HUMAN	zinc finger, H2C2 domain containing	87					DNA integration		DNA binding			ovary(1)|skin(1)	2		all_cancers(142;3.23e-07)|all_epithelial(76;3.64e-10)|Prostate(80;0.00914)|Ovarian(225;0.0139)|Lung NSC(167;0.0212)|Colorectal(57;0.0249)|all_lung(232;0.0283)		Epithelial(69;3.57e-14)|COAD - Colon adenocarcinoma(37;0.00794)		CTGGATATACCATGATGAGCT	0.363		NaN											0	0	0	1	0	16	8									
VDAC1	7416	broad.mit.edu	37	5	133326826	133326826	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr5:133326826G>A	uc003kyp.1	-	4	236	c.137C>T	c.(136-138)TCA>TTA	p.S46L	VDAC1_uc003kyq.1_Missense_Mutation_p.S46L|VDAC1_uc003kyr.1_Missense_Mutation_p.S46L	NM_003374	NP_003365	P21796	VDAC1_HUMAN	voltage-dependent anion channel 1	46	Beta stranded.				apoptosis|interspecies interaction between organisms	mitochondrial nucleoid|mitochondrial outer membrane|plasma membrane|pore complex	porin activity|protein binding|voltage-gated anion channel activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00806)|Kidney(363;0.02)		Dihydroxyaluminium(DB01375)	AGTGTTGGCTGAGCCTGAGCT	0.478		NaN											0	0	0	1	0	27	84									
PCDHA5	56143	broad.mit.edu	37	5	140201632	140201632	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr5:140201632G>A	uc003lhl.2	+	1	272	c.272G>A	c.(271-273)CGG>CAG	p.R91Q	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.R91Q|PCDHA5_uc003lhj.1_Missense_Mutation_p.R91Q	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	91	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGATCGACCGGGAGGAGCTG	0.622		NaN											0	0	0	1	0	13	243									
SIRT5	23408	broad.mit.edu	37	6	13588578	13588578	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr6:13588578G>A	uc003nay.2	+	4	427	c.131G>A	c.(130-132)CGA>CAA	p.R44Q	SIRT5_uc003naw.2_Missense_Mutation_p.R44Q|SIRT5_uc003nax.2_Intron|SIRT5_uc011dit.1_Missense_Mutation_p.R44Q	NM_012241	NP_036373	Q9NXA8	SIRT5_HUMAN	sirtuin 5 isoform 1	44	Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial intermembrane space|mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|zinc ion binding			skin(2)|upper_aerodigestive_tract(1)	3	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.176)		Suramin(DB04786)	GCAGATTTTCGAAAGTTTTTT	0.403		NaN											0	0	0	1	0	35	32									
DEF6	50619	broad.mit.edu	37	6	35287672	35287672	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr6:35287672G>A	uc003okk.2	+	9	1498	c.1459G>A	c.(1459-1461)GCG>ACG	p.A487T	DEF6_uc010jvs.2_Missense_Mutation_p.A462T|DEF6_uc010jvt.2_Missense_Mutation_p.A232T	NM_022047	NP_071330	Q9H4E7	DEFI6_HUMAN	differentially expressed in FDCP 6 homolog	487	Glu-rich.					cytoplasm|nucleus|plasma membrane					0						CATCGAACGGGCGCAGCAGGA	0.617		NaN											0	0	0	1	0	4	5									
XPO5	57510	broad.mit.edu	37	6	43495459	43495459	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr6:43495459C>T	uc003ovp.2	-	26	3044	c.2833G>A	c.(2833-2835)GAG>AAG	p.E945K	POLR1C_uc003ovo.1_Intron	NM_020750	NP_065801	Q9HAV4	XPO5_HUMAN	exportin 5	945					gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			skin(2)|breast(1)|kidney(1)	4	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			TCTGCAGCCTCATCTTCTCCA	0.507		NaN											0	0	0	1	0	35	44									
LMBRD1	55788	broad.mit.edu	37	6	70447864	70447864	+	Missense_Mutation	SNP	C	C	G			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr6:70447864C>G	uc003pfa.2	-	7	721	c.606G>C	c.(604-606)TTG>TTC	p.L202F	LMBRD1_uc003pey.2_5'UTR|LMBRD1_uc003pez.2_Missense_Mutation_p.L129F|LMBRD1_uc010kal.2_Missense_Mutation_p.L129F|LMBRD1_uc003pfb.2_RNA	NM_018368	NP_060838	Q9NUN5	LMBD1_HUMAN	liver regeneration p-53 related protein	202	Helical; Name=5; (Potential).				interspecies interaction between organisms|transport	integral to membrane|lysosomal membrane	cobalamin binding			ovary(1)	1						ACATTCCAATCAAGGTCAGAG	0.289		NaN											0	0	0	1	0	12	13									
MDN1	23195	broad.mit.edu	37	6	90421882	90421882	+	Silent	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr6:90421882G>A	uc003pnn.1	-	49	7640	c.7524C>T	c.(7522-7524)TAC>TAT	p.Y2508Y		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	2508					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		CATCGATCCAGTAAGTATTCA	0.408		NaN											0	0	0	1	0	94	115									
KPNA5	3841	broad.mit.edu	37	6	117045538	117045538	+	Silent	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr6:117045538G>A	uc003pxh.2	+	10	1130	c.999G>A	c.(997-999)CAG>CAA	p.Q333Q		NM_002269	NP_002260	O15131	IMA5_HUMAN	karyopherin alpha 5	330	NLS binding site (minor) (By similarity).|ARM 7.				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding|protein transporter activity			breast(3)|skin(1)	4		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0298)|all cancers(137;0.0461)|OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.212)		TTCAAACACAGGTGAGTTCAA	0.279		NaN											0	0	0	1	0	14	30									
DNAH11	8701	broad.mit.edu	37	7	21751477	21751477	+	Missense_Mutation	SNP	C	C	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr7:21751477C>A	uc003svc.2	+	43	7034	c.7003C>A	c.(7003-7005)CCG>ACG	p.P2335T		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2335	AAA 2 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GGGCTGGAATCCGTGAGTATT	0.279		NaN							Kartagener_syndrome				1	0	3.32936e-07	1	3.38846e-07	19	17									
FZD9	8326	broad.mit.edu	37	7	72848451	72848451	+	Silent	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr7:72848451G>A	uc003tyb.2	+	1	343	c.114G>A	c.(112-114)CCG>CCA	p.P38P		NM_003508	NP_003499	O00144	FZD9_HUMAN	frizzled 9 precursor	38	FZ.|Extracellular (Potential).				B cell differentiation|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|neuroblast proliferation|vasculature development	cell surface|filopodium membrane|integral to membrane|perinuclear region of cytoplasm	G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				GGGCTGCGCCGTGCCAGGCGG	0.761		NaN											0	0	0	1	0	20	17									
ZNF277	11179	broad.mit.edu	37	7	111981066	111981066	+	Silent	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr7:111981066G>A	uc003vge.2	+	11	1278	c.1149G>A	c.(1147-1149)TCG>TCA	p.S383S	ZNF277_uc003vgf.2_Silent_p.S305S|ZNF277_uc003vgg.2_Silent_p.S208S	NM_021994	NP_068834	Q9NRM2	ZN277_HUMAN	zinc finger protein (C2H2 type) 277	383						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|breast(2)	4						AACACACTTCGCTGCTCCCCG	0.423		NaN											0	0	0	1	0	44	50									
ARHGEF5	7984	broad.mit.edu	37	7	144077079	144077079	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr7:144077079G>A	uc003wel.2	+	15	4842	c.4724G>A	c.(4723-4725)CGT>CAT	p.R1575H	ARHGEF5_uc003wem.2_Missense_Mutation_p.R376H	NM_005435	NP_005426	Q12774	ARHG5_HUMAN	rho guanine nucleotide exchange factor 5	1575					intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			skin(2)	2	Melanoma(164;0.14)					CCAGAGGTCCGTGCACAGAAC	0.572		NaN											0	0	0	1	0	88	106									
CNTNAP2	26047	broad.mit.edu	37	7	147844772	147844772	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr7:147844772G>A	uc003weu.1	+	17	3260	c.2744G>A	c.(2743-2745)CGC>CAC	p.R915H		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	915	Laminin G-like 3.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GGCCACACCCGCCTGGAGCTC	0.522		NaN								HNSCC(39;0.1)			0	0	0	1	0	55	53									
ADRA1A	148	broad.mit.edu	37	8	26627912	26627912	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr8:26627912G>T	uc003xfh.1	-	2	1591	c.1155C>A	c.(1153-1155)TTC>TTA	p.F385L	ADRA1A_uc003xfc.1_Missense_Mutation_p.F385L|ADRA1A_uc010lul.1_Intron|ADRA1A_uc003xfd.1_Intron|ADRA1A_uc003xfe.1_Missense_Mutation_p.F385L|ADRA1A_uc010lum.1_Intron|ADRA1A_uc003xff.1_Intron|ADRA1A_uc003xfg.1_Missense_Mutation_p.F385L	NM_000680	NP_000671	P35348	ADA1A_HUMAN	alpha-1A-adrenergic receptor isoform 1	385	Cytoplasmic (By similarity).				activation of phospholipase C activity|aging|apoptosis|calcium ion transport into cytosol|cell-cell signaling|intracellular protein kinase cascade|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of synaptic transmission, GABAergic|positive regulation of action potential|positive regulation of cardiac muscle contraction|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase C signaling cascade|positive regulation of vasoconstriction|response to drug|response to hormone stimulus|response to stress|smooth muscle contraction	integral to plasma membrane	alpha1-adrenergic receptor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5		all_cancers(63;0.122)|Ovarian(32;2.61e-05)|all_epithelial(46;0.118)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;4.92e-10)|Colorectal(74;0.0132)|READ - Rectum adenocarcinoma(644;0.115)	Alfuzosin(DB00346)|Amiodarone(DB01118)|Amphetamine(DB00182)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Carvedilol(DB01136)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Epinastine(DB00751)|Epinephrine(DB00668)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Maprotiline(DB00934)|Mephentermine(DB01365)|Metaraminol(DB00610)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Nefazodone(DB01149)|Nicergoline(DB00699)|Nilutamide(DB00665)|Norepinephrine(DB00368)|Norgestrel(DB00506)|Oxymetazoline(DB00935)|Perphenazine(DB00850)|Phendimetrazine(DB01579)|Phenoxybenzamine(DB00925)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Prazosin(DB00457)|Promazine(DB00420)|Promethazine(DB01069)|Propericiazine(DB01608)|Propiomazine(DB00777)|Pseudoephedrine(DB00852)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Thioridazine(DB00679)|Tolazoline(DB00797)|Trazodone(DB00656)|Trifluoperazine(DB00831)|Ziprasidone(DB00246)	AGATCCTGTAGAAGGTCTCTC	0.557		NaN											1	0	3.33393e-45	1	3.49656e-45	106	118									
NKX6-3	157848	broad.mit.edu	37	8	41504183	41504183	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr8:41504183G>A	uc003xoa.2	-	2	197	c.193C>T	c.(193-195)CGG>TGG	p.R65W	NKX6-3_uc010lxa.1_Missense_Mutation_p.R65W	NM_152568	NP_689781	A6NJ46	NKX63_HUMAN	NK6 homeobox 3	195	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(28;0.00541)|Colorectal(14;0.0202)|Lung SC(25;0.211)	all_lung(54;0.0131)|Lung NSC(58;0.0363)|Esophageal squamous(32;0.0844)|Hepatocellular(245;0.154)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CTCTTCTTCCGCCACTTGGTC	0.572		NaN											0	0	0	1	0	5	9									
CHD7	55636	broad.mit.edu	37	8	61712986	61712986	+	Missense_Mutation	SNP	A	A	G			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr8:61712986A>G	uc003xue.2	+	5	2755	c.2278A>G	c.(2278-2280)ACT>GCT	p.T760A		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	760					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity	p.556_871dup(1)		ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			AAAGCGCTACACTGAAGACCT	0.453		NaN											0	0	0	1	0	21	21									
UBR5	51366	broad.mit.edu	37	8	103305851	103305851	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr8:103305851G>A	uc003ykr.1	-	34	4604	c.4571C>T	c.(4570-4572)TCA>TTA	p.S1524L	UBR5_uc003yks.1_Missense_Mutation_p.S1524L	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	1524					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CTGATCAGATGATGGTCGTGG	0.443		NaN											0	0	0	1	0	36	64									
COL22A1	169044	broad.mit.edu	37	8	139606405	139606405	+	Silent	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr8:139606405C>T	uc003yvd.2	-	63	4917	c.4470G>A	c.(4468-4470)GCG>GCA	p.A1490A	COL22A1_uc011ljo.1_Silent_p.A770A	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1490	Pro-rich.|Gly-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			ACTTCATGTACGCCGGGGGCA	0.602		NaN								HNSCC(7;0.00092)			0	0	0	1	0	40	59									
KANK1	23189	broad.mit.edu	37	9	734746	734746	+	Splice_Site	SNP	A	A	G			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr9:734746A>G	uc003zgl.1	+	11	3895	c.3246_splice	c.e11-2	p.R1082_splice	KANK1_uc003zgn.1_Splice_Site_p.R1082_splice|KANK1_uc003zgs.1_Splice_Site_p.R924_splice|KANK1_uc010mgx.1_Splice_Site_p.R37_splice|KANK1_uc010mgy.1_5'UTR|KANK1_uc003zgt.1_5'Flank	NM_015158	NP_055973	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1 isoform a						negative regulation of actin filament polymerization	cytoplasm				ovary(2)|central_nervous_system(1)|pancreas(1)	4		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		TTCTCCTTTCAGGTATGAATT	0.284		NaN											0	0	0	1	0	38	29									
SLC24A2	25769	broad.mit.edu	37	9	19573435	19573435	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr9:19573435C>T	uc003zoa.1	-	6	1323	c.1261G>A	c.(1261-1263)GAT>AAT	p.D421N	SLC24A2_uc003zob.1_Missense_Mutation_p.D404N	NM_020344	NP_065077	Q9UI40	NCKX2_HUMAN	solute carrier family 24	421	Cytoplasmic (Potential).				visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(3)	3				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		ATTTCAACATCTGTGCTGGTG	0.303		NaN											0	0	0	1	0	48	16									
VCP	7415	broad.mit.edu	37	9	35061086	35061086	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr9:35061086G>A	uc003zvy.2	-	11	1674	c.1285C>T	c.(1285-1287)CTC>TTC	p.L429F	VCP_uc003zvz.2_RNA|VCP_uc010mkh.1_Missense_Mutation_p.L98F|VCP_uc010mki.1_Missense_Mutation_p.L384F	NM_007126	NP_009057	P55072	TERA_HUMAN	valosin-containing protein	429					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			upper_aerodigestive_tract(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			AGGTCAATGAGATCCATCTTC	0.537		NaN											0	0	0	1	0	139	131									
RG9MTD3	158234	broad.mit.edu	37	9	37768130	37768130	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr9:37768130G>C	uc004aai.2	+	5	555	c.478G>C	c.(478-480)GAC>CAC	p.D160H	RG9MTD3_uc011lqo.1_Intron|RG9MTD3_uc011lqp.1_Missense_Mutation_p.D82H|RG9MTD3_uc011lqq.1_Missense_Mutation_p.D49H|RG9MTD3_uc004aaj.2_RNA|RG9MTD3_uc004aak.2_Missense_Mutation_p.D65H	NM_144964	NP_659401	Q6PF06	RG9D3_HUMAN	RNA (guanine-9-) methyltransferase domain	160							methyltransferase activity				0				GBM - Glioblastoma multiforme(29;0.00817)|Lung(182;0.226)		CAAAAAAGCTGACAGGCCATT	0.413		NaN											0	0	0	1	0	77	100									
XPA	7507	broad.mit.edu	37	9	100459547	100459547	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr9:100459547C>T	uc004axr.3	-	1	145	c.28G>A	c.(28-30)GAG>AAG	p.E10K	XPA_uc004axs.3_RNA	NM_000380	NP_000371	P23025	XPA_HUMAN	xeroderma pigmentosum, complementation group A	10	Interaction with CEP164 and required for UV resistance.				nucleotide-excision repair, DNA damage removal	nucleoplasm	damaged DNA binding|metal ion binding|nucleotide binding|protein domain specific binding|protein homodimerization activity			breast(1)	1		Acute lymphoblastic leukemia(62;0.158)				GCCGCCGCCTCCGGCAAAGCC	0.736		NaN	Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		NER	Xeroderma_Pigmentosum				0	0	0	1	0	21	20									
SPTAN1	6709	broad.mit.edu	37	9	131379944	131379944	+	Missense_Mutation	SNP	G	G	C			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr9:131379944G>C	uc004bvl.3	+	41	5481	c.5368G>C	c.(5368-5370)GAG>CAG	p.E1790Q	SPTAN1_uc004bvm.3_Missense_Mutation_p.E1795Q|SPTAN1_uc004bvn.3_Missense_Mutation_p.E1770Q	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1790	Spectrin 19.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GGTGGGCTCAGAGGACTACGG	0.572		NaN											0	0	0	1	0	27	6									
SPTAN1	6709	broad.mit.edu	37	9	131379988	131379988	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr9:131379988G>T	uc004bvl.3	+	41	5525	c.5412G>T	c.(5410-5412)AAG>AAT	p.K1804N	SPTAN1_uc004bvm.3_Missense_Mutation_p.K1809N|SPTAN1_uc004bvn.3_Missense_Mutation_p.K1784N	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1804	Spectrin 19.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						ACCTGAGGAAGAAGCACAAGC	0.597		NaN											1	0	3.76604e-16	1	3.87879e-16	39	8									
SPTAN1	6709	broad.mit.edu	37	9	131380380	131380380	+	Missense_Mutation	SNP	G	G	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr9:131380380G>T	uc004bvl.3	+	42	5691	c.5578G>T	c.(5578-5580)GCT>TCT	p.A1860S	SPTAN1_uc004bvm.3_Missense_Mutation_p.A1865S|SPTAN1_uc004bvn.3_Missense_Mutation_p.A1840S	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1860	Spectrin 19.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GCAGCTGGCAGCTGCCCGGTG	0.612		NaN											1	0	6.04917e-29	1	6.26782e-29	43	4									
SPTAN1	6709	broad.mit.edu	37	9	131381226	131381226	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr9:131381226G>A	uc004bvl.3	+	43	5775	c.5662G>A	c.(5662-5664)GAG>AAG	p.E1888K	SPTAN1_uc004bvm.3_Missense_Mutation_p.E1893K|SPTAN1_uc004bvn.3_Missense_Mutation_p.E1868K	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1888	Spectrin 20.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						CTGGATCAATGAGAAAATGAC	0.498		NaN											0	0	0	1	0	37	6									
TOR1B	27348	broad.mit.edu	37	9	132565654	132565654	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr9:132565654G>A	uc004byk.1	+	1	223	c.163G>A	c.(163-165)GAG>AAG	p.E55K		NM_014506	NP_055321	O14657	TOR1B_HUMAN	torsin family 1, member B (torsin B) precursor	55					chaperone mediated protein folding requiring cofactor|response to unfolded protein	endoplasmic reticulum lumen	ATP binding|nucleoside-triphosphatase activity|unfolded protein binding				0		Ovarian(14;0.0586)				CCGCTTCGCCGAGTGCTGCCG	0.602		NaN											0	0	0	1	0	21	2									
TOR1B	27348	broad.mit.edu	37	9	132565666	132565666	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr9:132565666G>A	uc004byk.1	+	1	235	c.175G>A	c.(175-177)GAG>AAG	p.E59K		NM_014506	NP_055321	O14657	TOR1B_HUMAN	torsin family 1, member B (torsin B) precursor	59					chaperone mediated protein folding requiring cofactor|response to unfolded protein	endoplasmic reticulum lumen	ATP binding|nucleoside-triphosphatase activity|unfolded protein binding				0		Ovarian(14;0.0586)				GTGCTGCCGCGAGGAGCGGCC	0.602		NaN											0	0	0	1	0	20	3									
ZCCHC5	203430	broad.mit.edu	37	X	77912861	77912861	+	Missense_Mutation	SNP	C	C	T			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chrX:77912861C>T	uc004edc.1	-	2	1353	c.1057G>A	c.(1057-1059)GAT>AAT	p.D353N		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	353							nucleic acid binding|zinc ion binding			ovary(1)	1						GTGCTTTCATCCCAGTTCAGC	0.473		NaN											0	0	0	1	0	20	3									
PABPC5	140886	broad.mit.edu	37	X	90691635	90691635	+	Silent	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chrX:90691635G>A	uc004efg.2	+	2	1499	c.1059G>A	c.(1057-1059)GAG>GAA	p.E353E	PABPC5_uc004eff.1_Silent_p.E189E	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	353	RRM 4.					cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						CTTTTGAAGAGGCTACCAAAG	0.517		NaN											0	0	0	1	0	29	2									
RGAG1	57529	broad.mit.edu	37	X	109697193	109697193	+	Silent	SNP	A	A	G			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chrX:109697193A>G	uc004eor.1	+	3	3594	c.3348A>G	c.(3346-3348)GGA>GGG	p.G1116G	RGAG1_uc011msr.1_Silent_p.G1116G	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	1116										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						CAGCCTCTGGATCAAAGCCCA	0.527		NaN											0	0	0	1	0	110	8									
HTR2C	3358	broad.mit.edu	37	X	114141244	114141244	+	Missense_Mutation	SNP	G	G	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chrX:114141244G>A	uc004epu.1	+	6	1371	c.643G>A	c.(643-645)GTT>ATT	p.V215I	HTR2C_uc010nqc.1_Missense_Mutation_p.V215I|HTR2C_uc004epv.1_Missense_Mutation_p.R183H	NM_000868	NP_000859	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C	215	Helical; Name=5; (By similarity).				cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			ovary(3)	3					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	CCCAAATTTCGTTCTTATTGG	0.468		NaN											0	0	0	1	0	191	15									
LRRC8B	23507	broad.mit.edu	37	1	90058386	90058386	+	Frame_Shift_Del	DEL	G	G	-			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr1:90058386delG	uc001dni.2	+	8	2703	c.2196delG	c.(2194-2196)TTGfs	p.L732fs	LRRC8B_uc001dnh.2_Frame_Shift_Del_p.L732fs|LRRC8B_uc001dnj.2_Frame_Shift_Del_p.L732fs	NM_001134476	NP_001127948	Q6P9F7	LRC8B_HUMAN	leucine rich repeat containing 8 family, member	732	LRR 12.					integral to membrane				ovary(2)	2		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)		GTTTACTTTTGGGGAAAAATA	0.423		NaN											NaN	NaN	NaN	NaN	NaN	47	69	---	---							
GPR137C	283554	broad.mit.edu	37	14	53101795	53101798	+	Frame_Shift_Del	DEL	AACA	AACA	-			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr14:53101795_53101798delAACA	uc001wzu.3	+	7	1252_1255	c.1252_1255delAACA	c.(1252-1257)AACAATfs	p.N418fs	GPR137C_uc001wzt.3_Frame_Shift_Del_p.N434fs	NM_001099652	NP_001093122	Q8N3F9	G137C_HUMAN	G protein-coupled receptor 137C	418_419	Cytoplasmic (Potential).					integral to membrane					0	Breast(41;0.0716)					TTTAGATTTGAACAATCATCATAG	0.382		NaN											NaN	NaN	NaN	NaN	NaN	15	52	---	---							
CDC27	996	broad.mit.edu	37	17	45247389	45247389	+	Frame_Shift_Del	DEL	T	T	-			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr17:45247389delT	uc002ild.3	-	4	398	c.271delA	c.(271-273)ATCfs	p.I91fs	CDC27_uc002ile.3_Frame_Shift_Del_p.I91fs|CDC27_uc002ilf.3_Frame_Shift_Del_p.I91fs|CDC27_uc010wkp.1_Frame_Shift_Del_p.I30fs|CDC27_uc010wkq.1_RNA	NM_001256	NP_001247	P30260	CDC27_HUMAN	cell division cycle protein 27 isoform 2	91	TPR 1.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			lung(2)|breast(2)|ovary(1)	5						CCAGATAAGATTTGTTCCCCT	0.323		NaN											NaN	NaN	NaN	NaN	NaN	9	154	---	---							
GRLF1	2909	broad.mit.edu	37	19	47423804	47423804	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr19:47423804delC	uc010ekv.2	+	1	1872	c.1872delC	c.(1870-1872)GACfs	p.D624fs		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	glucocorticoid receptor DNA binding factor 1	624					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity			central_nervous_system(1)	1		all_cancers(25;1.51e-09)|all_epithelial(76;1.87e-07)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|Ovarian(192;0.0129)|all_neural(266;0.026)|Breast(70;0.077)		all cancers(93;2.03e-05)|OV - Ovarian serous cystadenocarcinoma(262;2.57e-05)|Epithelial(262;0.00135)|GBM - Glioblastoma multiforme(486;0.0289)		CAAATGATGACAAGTATGTGA	0.448		NaN											NaN	NaN	NaN	NaN	NaN	121	131	---	---							
MYH9	4627	broad.mit.edu	37	22	36698721	36698722	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr22:36698721_36698722delCT	uc003apg.2	-	20	2622_2623	c.2391_2392delAG	c.(2389-2394)AAAGCAfs	p.K797fs	MYH9_uc003aph.1_Frame_Shift_Del_p.K661fs	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	797_798	IQ.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						TTGGCAAATGCTCTGTGTGGTG	0.599		NaN	T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				NaN	NaN	NaN	NaN	NaN	39	43	---	---							
EP300	2033	broad.mit.edu	37	22	41523722	41523723	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08			AC	-	AC	AC		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr22:41523722_41523723delAC	uc003azl.3	+	4	1533_1534	c.1138_1139delAC	c.(1138-1140)ACAfs	p.T380fs		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	380	TAZ-type 1.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						AAACCACATGACACACTGCCAG	0.51		NaN	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				NaN	NaN	NaN	NaN	NaN	55	72	---	---							
NOP14	8602	broad.mit.edu	37	4	2954005	2954006	+	Frame_Shift_Ins	INS	-	-	A			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr4:2954005_2954006insA	uc003ggj.1	-	6	938_939	c.866_867insT	c.(865-867)CTGfs	p.L289fs	C4orf10_uc003ggi.1_Intron|NOP14_uc010icp.2_Frame_Shift_Ins_p.L35fs|NOP14_uc003ggk.3_Frame_Shift_Ins_p.L289fs|NOP14_uc003ggl.2_Frame_Shift_Ins_p.L289fs|NOP14_uc010icq.1_RNA	NM_003703	NP_003694	P78316	NOP14_HUMAN	probable nucleolar complex protein 14	289					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			pancreas(1)	1						ACCCTACCTCCAGCTTCCTGAG	0.559		NaN											NaN	NaN	NaN	NaN	NaN	23	85	---	---							
MLL3	58508	broad.mit.edu	37	7	151843779	151843788	+	Frame_Shift_Del	DEL	TTCTCACACA	TTCTCACACA	-	rs142657994	byFrequency	TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08			TTCTCACACA	-	TTCTCACACA	TTCTCACACA		Valid	Somatic	Phase_I	WXS	Fluidigm_realigned			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr7:151843779_151843788delTTCTCACACA	uc003wla.2	-	53	14146_14155	c.13927_13936delTGTGTGAGAA	c.(13927-13938)TGTGTGAGAAAAfs	p.C4643fs	MLL3_uc003wkz.2_Frame_Shift_Del_p.C3761fs|MLL3_uc003wkx.2_Frame_Shift_Del_p.C801fs|MLL3_uc003wky.2_Frame_Shift_Del_p.C2207fs	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	4643_4646	FYR C-terminal.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TCAGACTTTTTTCTCACACATGCCACAGGC	0.419		NaN	N		medulloblastoma						OREG0018460	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	NaN	NaN	NaN	NaN	NaN	25	52	---	---							
CDKN2A	1029	broad.mit.edu	37	9	21971092	21971093	+	Frame_Shift_Del	DEL	CC	CC	-	rs137854599		TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08			CC	-	CC	CC		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr9:21971092_21971093delCC	uc003zpk.2	-	2	477_478	c.265_266delGG	c.(265-267)GGCfs	p.G89fs	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Frame_Shift_Del_p.G144fs	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	89	ANK 3.		G -> D (in CMM2; somatic mutation).|G -> S (in CMM2).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.G89S(4)|p.H83fs*2(2)|p.D84_F90del(1)|p.V82_G89>G(1)|p.G89V(1)|p.E61_L94del(1)|p.R137fs*48(1)|p.A68fs*3(1)|p.G89fs*57(1)|p.G89G(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GTCCAGGAAGCCCTCCCGGGCA	0.757		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			NaN	NaN	NaN	NaN	NaN	17	2	---	---							
SPTAN1	6709	broad.mit.edu	37	9	131381207	131381207	+	Frame_Shift_Del	DEL	G	G	-			TCGA-GC-A3BM-01A-11D-A22Z-08	TCGA-GC-A3BM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61da0825-106b-493c-8ccd-e8108b499a9c	0f0c391b-efb0-43d3-b6a5-c53b9fa0f477	g.chr9:131381207delG	uc004bvl.3	+	43	5756	c.5643delG	c.(5641-5643)GAGfs	p.E1881fs	SPTAN1_uc004bvm.3_Frame_Shift_Del_p.E1886fs|SPTAN1_uc004bvn.3_Frame_Shift_Del_p.E1861fs	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1881	Spectrin 20.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						ATGTGGAAGAGGAAGAAGCCT	0.498		NaN											NaN	NaN	NaN	NaN	NaN	41	7	---	---							
