Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
INSRR	3645	broad.mit.edu	37	1	156828332	156828332	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:156828332C>T	ENST00000368195.3	-	1	478	c.82G>A	c.(82-84)Gag>Aag	p.E28K	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	28					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GACTCACCCTCTACTGTATCC	0.597000													19	60					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13780976	13780976	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:13780976G>A	ENST00000265104.4	-	53	9017	c.8913C>T	c.(8911-8913)ttC>ttT	p.F2971F		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2971	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					AGCCAGCAATGAATGAAGCCA	0.488000									Kartagener syndrome				20	15					0	0	1	0	0
TP53BP2	7159	broad.mit.edu	37	1	223981107	223981107	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:223981107C>T	ENST00000391878.2	-	15	3141	c.2373G>A	c.(2371-2373)gaG>gaA	p.E791E	TP53BP2_ENST00000498843.1_5'UTR|TP53BP2_ENST00000391879.2_Silent_p.E153E|TP53BP2_ENST00000343537.7_Silent_p.E920E	NM_005426.2	NP_005417.1	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2	914					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(2)	29				GBM - Glioblastoma multiforme(131;0.0958)		GAGCGATACGCTCTGAGCCAG	0.423000													16	93					0	0	1	0	0
ELK4	2005	broad.mit.edu	37	1	205589524	205589524	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:205589524G>C	ENST00000357992.4	-	3	989	c.650C>G	c.(649-651)tCt>tGt	p.S217C	ELK4_ENST00000289703.4_Missense_Mutation_p.S217C	NM_001973.3	NP_001964.2			ELK4, ETS-domain protein (SRF accessory protein 1)										SLC45A3/ELK4(18)	breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|skin(1)	12	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			TTCTTCTGAAGATGGAGAAAT	0.478000			T	SLC45A3	prostate								23	45					0	0	1	0	0
OR2B11	127623	broad.mit.edu	37	1	247614864	247614864	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:247614864G>C	ENST00000318749.6	-	1	444	c.421C>G	c.(421-423)Cac>Gac	p.H141D		NM_001004492.1	NP_001004492.1	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B, member 11	141					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(13)|large_intestine(7)|lung(31)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	60	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			AGAGCACGGTGCATGAGAACG	0.632000													21	7					0	0	1	0	0
PTPN4	5775	broad.mit.edu	37	2	120725515	120725515	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:120725515G>A	ENST00000263708.2	+	26	3432	c.2661G>A	c.(2659-2661)atG>atA	p.M887I	PTPN4_ENST00000544261.1_Missense_Mutation_p.M520I	NM_002830.3	NP_002821.1	P29074	PTN4_HUMAN	protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)	887	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity			endometrium(3)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|urinary_tract(1)	30					Alendronate(DB00630)	TAAGAACAATGAGAGATCAGC	0.373000													42	51					0	0	1	0	0
NCOA3	8202	broad.mit.edu	37	20	46279947	46279947	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr20:46279947C>T	ENST00000372004.3	+	20	4077	c.3861C>T	c.(3859-3861)agC>agT	p.S1287S	NCOA3_ENST00000371998.3_Silent_p.S1291S|NCOA3_ENST00000341724.6_Silent_p.S1217S|NCOA3_ENST00000371997.3_Silent_p.S1282S	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	1291	Acetyltransferase.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						CTTCCCCCAGCATGGATGGGC	0.512000													27	54					0	0	1	0	0
GPNMB	10457	broad.mit.edu	37	7	23313759	23313759	+	Silent	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:23313759C>G	ENST00000258733.4	+	11	1894	c.1599C>G	c.(1597-1599)ctC>ctG	p.L533L	GPNMB_ENST00000539136.1_Silent_p.L434L|GPNMB_ENST00000478451.1_3'UTR|GPNMB_ENST00000381990.2_Silent_p.L545L|GPNMB_ENST00000453162.2_Silent_p.L487L			Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb	545					negative regulation of cell proliferation	melanosome		p.L545L(1)		breast(5)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(3)|stomach(2)	41			GBM - Glioblastoma multiforme(13;0.154)			GTGTCTTTCTCAACCGTGCAA	0.408000													35	70					0	0	1	0	0
GNA11	2767	broad.mit.edu	37	19	3118955	3118955	+	Silent	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:3118955G>C	ENST00000078429.4	+	5	881	c.639G>C	c.(637-639)cgG>cgC	p.R213R	GNA11_ENST00000586180.1_3'UTR|AC005262.3_ENST00000587701.1_RNA	NM_002067.2	NP_002058.2	P29992	GNA11_HUMAN	guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	213					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation|regulation of action potential	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			endometrium(2)|eye(132)|kidney(1)|large_intestine(2)|lung(1)|meninges(5)|ovary(1)|prostate(1)|skin(16)	161		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.79e-05)|OV - Ovarian serous cystadenocarcinoma(105;2.68e-113)|Epithelial(107;1.22e-111)|all cancers(105;5.78e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00141)|STAD - Stomach adenocarcinoma(1328;0.181)		GGTCGGAGCGGAGGAAGTGGA	0.607000			Mis		uveal melanoma								22	36					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73678073	73678073	+	Silent	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:73678073C>A	ENST00000264448.6	+	8	4527	c.4416C>A	c.(4414-4416)tcC>tcA	p.S1472S	ALMS1_ENST00000409009.1_Silent_p.S1430S|ALMS1_ENST00000377715.1_Silent_p.S1472S	NM_015120.4	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1472	34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						CTGTAACCTCCCCTTCCAGCT	0.483000													58	77					2.22609e-26	2.41952e-26	1	1	0
NOTCH2NL	388677	broad.mit.edu	37	1	145281506	145281506	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:145281506G>C	ENST00000369340.3	+	5	880	c.436G>C	c.(436-438)Gag>Cag	p.E146Q	NOTCH2NL_ENST00000344859.3_Missense_Mutation_p.E146Q|NOTCH2NL_ENST00000362074.6_Missense_Mutation_p.E146Q|RP11-458D21.5_ENST00000468030.1_Missense_Mutation_p.E146Q			Q7Z3S9	NT2NL_HUMAN	notch 2 N-terminal like	146	EGF-like 5; calcium-binding (Potential).				cell differentiation|multicellular organismal development|Notch signaling pathway	cytoplasm|extracellular region	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	27						TGATGTCAATGAGTGTGACAT	0.552000													41	295					0	0	1	0	0
KRT5	3852	broad.mit.edu	37	12	52911010	52911010	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:52911010C>G	ENST00000252242.4	-	6	1489	c.1099G>C	c.(1099-1101)Gag>Cag	p.E367Q		NM_000424.3	NP_000415.2	P13647	K2C5_HUMAN	keratin 5	367	Coil 2.|Rod.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(5)|kidney(1)|large_intestine(8)|lung(15)|prostate(4)|skin(2)	35				BRCA - Breast invasive adenocarcinoma(357;0.189)		TGCTGCAGCTCCTCATACTGA	0.507000													23	35					0	0	1	0	0
LEMD3	23592	broad.mit.edu	37	12	65634707	65634707	+	Silent	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:65634707C>G	ENST00000308330.2	+	9	2171	c.2145C>G	c.(2143-2145)gtC>gtG	p.V715V		NM_001167614.1|NM_014319.4	NP_001161086.1|NP_055134.2	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	715	Interaction with SMAD1, SMAD2, SMAD3 and SMAD5.				negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	36			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		TGAAGAAAGTCTGGGATAGAG	0.388000													19	33					0	0	1	0	0
TNS1	7145	broad.mit.edu	37	2	218696221	218696221	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:218696221C>T	ENST00000171887.4	-	20	3407	c.2955G>A	c.(2953-2955)ctG>ctA	p.L985L	TNS1_ENST00000419504.1_Silent_p.L985L|TNS1_ENST00000430930.1_Silent_p.L985L	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	985						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TGTGAGGTTTCAGGCCCAGAG	0.652000													7	5					0	0	1	0	0
SAFB	6294	broad.mit.edu	37	19	5668276	5668276	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:5668276G>A	ENST00000292123.5	+	21	2829	c.2722G>A	c.(2722-2724)Gat>Aat	p.D908N	SAFB_ENST00000454510.1_Missense_Mutation_p.D841N|SAFB_ENST00000538656.1_Missense_Mutation_p.D752N|SAFB_ENST00000433404.1_Missense_Mutation_p.D740N|SAFB_ENST00000592224.1_Missense_Mutation_p.D909N|SAFB_ENST00000588852.1_Missense_Mutation_p.D910N	NM_001201338.1|NM_001201339.1|NM_002967.3	NP_001188267.1|NP_001188268.1|NP_002958.2	Q15424	SAFB1_HUMAN	scaffold attachment factor B	908	Interaction with SAFB2.				chromatin organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding			breast(3)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|liver(1)|lung(6)|ovary(2)|skin(1)	23				UCEC - Uterine corpus endometrioid carcinoma (162;0.000222)		CAGGCCCAGCGATGCCCGCTT	0.622000													13	23					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43817926	43817926	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:43817926G>C	ENST00000382031.1	+	5	5000	c.4969G>C	c.(4969-4971)Gac>Cac	p.D1657H	MAP1A_ENST00000399453.1_Missense_Mutation_p.D1419H|MAP1A_ENST00000300231.5_Missense_Mutation_p.D1419H			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1419						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	AGAGCAAAAAGACACAGCCCT	0.438000													10	14					0	0	1	0	0
SPAST	6683	broad.mit.edu	37	2	32339806	32339806	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:32339806C>T	ENST00000315285.3	+	5	907	c.782C>T	c.(781-783)tCa>tTa	p.S261L	SPAST_ENST00000345662.1_Missense_Mutation_p.S229L	NM_014946.3	NP_055761.2	Q9UBP0	SPAST_HUMAN	spastin	261	Required for interaction with RTN1.|Sufficient for interaction with microtubules.|Sufficient for microtubule severing.				cell cycle|cell death|cell differentiation|cytokinesis, completion of separation|ER to Golgi vesicle-mediated transport|microtubule bundle formation|microtubule severing|nervous system development|protein hexamerization|protein homooligomerization	endoplasmic reticulum|endosome|integral to membrane|microtubule|microtubule organizing center|nucleus|perinuclear region of cytoplasm|spindle	alpha-tubulin binding|ATP binding|beta-tubulin binding|microtubule binding|microtubule-severing ATPase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(8)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					GCAGGCCTTTCAGGCCACCAT	0.453000													33	42					0	0	1	0	0
PTPN11	5781	broad.mit.edu	37	12	112915812	112915812	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:112915812G>A	ENST00000351677.2	+	9	1283	c.1085G>A	c.(1084-1086)aGa>aAa	p.R362K	PTPN11_ENST00000392597.1_Missense_Mutation_p.R362K	NM_002834.3	NP_002825.3	Q06124	PTN11_HUMAN	protein tyrosine phosphatase, non-receptor type 11	362	Tyrosine-protein phosphatase.				axon guidance|cell junction assembly|ephrin receptor signaling pathway|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|platelet activation|regulation of cell adhesion mediated by integrin|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol	non-membrane spanning protein tyrosine phosphatase activity|protein binding			NS(1)|autonomic_ganglia(2)|breast(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(406)|kidney(2)|large_intestine(6)|lung(16)|ovary(1)|skin(1)|soft_tissue(3)|stomach(3)	451						GAAGTGGAGAGAGGAAAGGTA	0.403000			Mis		"""JMML, AML, MDS"""		Noonan Syndrome		Noonan syndrome				24	18					0	0	1	0	0
BCL7A	605	broad.mit.edu	37	12	122492851	122492851	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:122492851C>G	ENST00000538010.1	+	5	3250	c.580C>G	c.(580-582)Cag>Gag	p.Q194E	BCL7A_ENST00000261822.4_Intron	NM_020993.3	NP_066273.1	Q4VC05	BCL7A_HUMAN	B-cell CLL/lymphoma 7A	187					negative regulation of transcription, DNA-dependent					haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	18	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000202)|Epithelial(86;0.000386)|BRCA - Breast invasive adenocarcinoma(302;0.231)		CTCGAGGTCTCAGAGGGGCAG	0.557000			T	MYC	BNHL						OREG0022214	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	47	40					0	0	1	0	0
MRPL20	55052	broad.mit.edu	37	1	1337537	1337537	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:1337537C>T	ENST00000344843.7	-	4	471	c.376G>A	c.(376-378)Gaa>Aaa	p.E126K	MRPL20_ENST00000493287.1_5'UTR	NM_017971.3	NP_060441.2	Q9BYC9	RM20_HUMAN	mitochondrial ribosomal protein L20	126							protein binding|rRNA binding	p.E126K(1)		endometrium(1)|large_intestine(1)|lung(2)|prostate(1)	5	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GCAAATCCTTCGTGTCGCCTC	0.517000													34	112					0	0	1	0	0
SEC61A2	55176	broad.mit.edu	37	10	12199015	12199015	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:12199015C>T	ENST00000379033.3	+	7	807	c.660C>T	c.(658-660)ctC>ctT	p.L220L	SEC61A2_ENST00000298428.9_Silent_p.L242L|SEC61A2_ENST00000379020.4_Silent_p.L242L|SEC61A2_ENST00000304267.8_Silent_p.L242L|SEC61A2_ENST00000495368.1_3'UTR	NM_001142628.1	NP_001136100.1	Q9H9S3	S61A2_HUMAN	Sec61 alpha 2 subunit (S. cerevisiae)	242						endoplasmic reticulum membrane|integral to membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		Renal(717;0.228)				TACCCAATCTCATGAACCTCA	0.403000													38	34					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17056199	17056199	+	Splice_Site	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:17056199G>A	ENST00000418129.2	+	3	2901		c.e3-1		PLCL2_ENST00000432376.1_Splice_Site|PLCL2_ENST00000396755.2_Splice_Site	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2						intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						CCATTTAACAGAATGCGGTGG	0.453000													103	109					0	0	1	0	0
THY1	7070	broad.mit.edu	37	11	119290965	119290965	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:119290965C>G	ENST00000284240.5	-	3	1208	c.169G>C	c.(169-171)Gag>Cag	p.E57Q	THY1_ENST00000580275.1_Missense_Mutation_p.E40Q|THY1_ENST00000527590.1_5'UTR|USP2-AS1_ENST00000500970.1_RNA|THY1_ENST00000528522.1_Missense_Mutation_p.E57Q|USP2-AS1_ENST00000530002.1_RNA|USP2-AS1_ENST00000498979.2_RNA|USP2-AS1_ENST00000578923.1_RNA	NM_006288.3	NP_006279.2	P04216	THY1_HUMAN	Thy-1 cell surface antigen	57	Ig-like V-type.				angiogenesis|cell-cell adhesion|cytoskeleton organization|focal adhesion assembly|negative regulation of axonogenesis|negative regulation of cell migration|negative regulation of protein kinase activity|negative regulation of T cell receptor signaling pathway|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of T cell activation|retinal cone cell development|T cell receptor signaling pathway	endoplasmic reticulum|growth cone|integral to plasma membrane|membrane raft	GPI anchor binding|integrin binding|Rho GTPase activator activity			breast(1)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	12		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.83e-05)		TTCTTTGTCTCACGGGTCAGG	0.557000													36	63					0	0	1	0	0
KCNF1	3754	broad.mit.edu	37	2	11053024	11053024	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:11053024G>A	ENST00000295082.1	+	1	962	c.472G>A	c.(472-474)Gag>Aag	p.E158K		NM_002236.4	NP_002227.2	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F, member 1	158						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(2)|skin(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		GGACGCAGCCGAGGGCCGCTG	0.692000													7	27					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64428408	64428408	+	Nonsense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:64428408G>A	ENST00000265459.6	-	10	2463	c.2002C>T	c.(2002-2004)Cga>Tga	p.R668*	NRXN2_ENST00000377559.3_Nonsense_Mutation_p.R637*|NRXN2_ENST00000409571.1_Nonsense_Mutation_p.R661*|NRXN2_ENST00000377551.1_Nonsense_Mutation_p.R668*|NRXN2_ENST00000496291.1_5'UTR	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	668	Laminin G-like 3.				cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						CGGAGGTCTCGGCTACGCCCA	0.687000													6	21					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16910736	16910736	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:16910736C>T	ENST00000524140.2	+	17	3917	c.3499C>T	c.(3499-3501)Ctg>Ttg	p.L1167L	NWD1_ENST00000379808.3_Silent_p.L1167L|NWD1_ENST00000552788.1_Silent_p.L1167L|NWD1_ENST00000549814.1_Intron|NWD1_ENST00000523826.1_Silent_p.L961L|NWD1_ENST00000339803.6_Silent_p.L1032L	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1167							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TCTGGACATCCTGGAAGGCGT	0.582000													12	65					0	0	1	0	0
PVR	5817	broad.mit.edu	37	19	45157177	45157177	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:45157177G>C	ENST00000425690.3	+	4	1032	c.733G>C	c.(733-735)Gag>Cag	p.E245Q	CTB-171A8.1_ENST00000590796.1_RNA|PVR_ENST00000403059.4_Missense_Mutation_p.E245Q|PVR_ENST00000344956.4_Missense_Mutation_p.E245Q|PVR_ENST00000406449.4_Missense_Mutation_p.E245Q	NM_006505.3	NP_006496.3	P15151	PVR_HUMAN	poliovirus receptor	245	Ig-like C2-type 2.				adherens junction organization|cell adhesion|cell junction assembly|interspecies interaction between organisms|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity	cell junction|cell surface|cytoplasm|extracellular space|integral to membrane|nucleus	cell adhesion molecule binding|receptor activity			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	6	Lung NSC(12;0.00608)|all_lung(12;0.0148)	Medulloblastoma(540;0.0425)|Ovarian(192;0.0728)|Prostate(69;0.081)|all_neural(266;0.112)		Epithelial(262;0.000601)		AGACCCCCCAGAGGTATCCAT	0.582000													67	141					0	0	1	0	0
ZNF57	126295	broad.mit.edu	37	19	2917103	2917103	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:2917103C>T	ENST00000306908.5	+	4	632	c.484C>T	c.(484-486)Cac>Tac	p.H162Y	ZNF57_ENST00000523428.1_Missense_Mutation_p.H130Y|AC006277.2_ENST00000520090.2_RNA	NM_173480.2	NP_775751.1	Q68EA5	ZNF57_HUMAN	zinc finger protein 57	162					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.00161)|STAD - Stomach adenocarcinoma(1328;0.18)		CGTCAAGTCTCACTGTGGACG	0.488000													22	30					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33878240	33878240	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:33878240G>C	ENST00000389232.4	+	16	1781	c.1711G>C	c.(1711-1713)Gaa>Caa	p.E571Q	RYR3_ENST00000415757.3_Missense_Mutation_p.E571Q	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	571					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGAAAGCCCAGAAGCCTTAAA	0.458000													15	33					0	0	1	0	0
TPR	7175	broad.mit.edu	37	1	186340104	186340104	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:186340104G>C	ENST00000367478.4	-	3	624	c.328C>G	c.(328-330)Cag>Gag	p.Q110E	TPR_ENST00000474852.1_5'UTR	NM_003292.2	NP_003283.2	P12270	TPR_HUMAN	translocated promoter region, nuclear basket protein						carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			autonomic_ganglia(1)|breast(5)|central_nervous_system(4)|cervix(2)|endometrium(9)|kidney(12)|large_intestine(23)|liver(1)|lung(45)|ovary(2)|pancreas(1)|prostate(6)|skin(3)|stomach(1)|urinary_tract(8)	123		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		TCTCTTACCTGAATGGCAATA	0.323000			T	NTRK1	papillary thyroid								91	101					0	0	1	0	0
SLC22A12	116085	broad.mit.edu	37	11	64360269	64360269	+	Missense_Mutation	SNP	T	T	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:64360269T>C	ENST00000377574.1	+	2	1168	c.421T>C	c.(421-423)Tct>Cct	p.S141P	SLC22A12_ENST00000377567.2_Missense_Mutation_p.S141P|SLC22A12_ENST00000473690.1_5'UTR|SLC22A12_ENST00000377572.1_Missense_Mutation_p.S141P|SLC22A12_ENST00000336464.7_Missense_Mutation_p.S141P	NM_144585.2	NP_653186.2	Q96S37	S22AC_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 12	141					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27						CGTGTGTGACTCTCATGCTCT	0.637000													17	60					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25312988	25312988	+	RNA	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:25312988G>A	ENST00000549804.2	+	0	538				SNORD116-7_ENST00000384404.1_RNA|SNHG14_ENST00000551077.1_RNA																							TGAACAAAATGAGTGAGAACT	0.507000													63	119					0	0	1	0	0
IGFL3	388555	broad.mit.edu	37	19	46627883	46627883	+	Splice_Site	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:46627883C>T	ENST00000341415.2	-	1	48	c.24G>A	c.(22-24)ttG>ttA	p.L8L	AC007193.6_ENST00000597989.1_lincRNA	NM_207393.1	NP_997276.1	Q6UXB1	IGFL3_HUMAN	IGF-like family member 3	8						extracellular region	protein binding			endometrium(1)|large_intestine(1)|lung(5)	7		Ovarian(192;0.0175)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00473)|GBM - Glioblastoma multiforme(486;0.0149)|Epithelial(262;0.239)		CCTACTTGCCCAAGATGCAGC	0.453000													14	41					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140347512	140347512	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:140347512C>T	ENST00000289269.5	+	1	1693	c.1161C>T	c.(1159-1161)ctC>ctT	p.L387L	PCDHA13_ENST00000409494.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHAC1_ENST00000253807.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA8_ENST00000531613.1_Intron	NM_018899.5|NM_031883.2	NP_061722.1|NP_114089.1	Q9Y5I4	PCDC2_HUMAN		387	Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGCCGTTCTCAGTGTCAATG	0.547000													13	46					0	0	1	0	0
TMC7	79905	broad.mit.edu	37	16	19067983	19067983	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:19067983C>T	ENST00000421369.3	+	14	2219	c.1661C>T	c.(1660-1662)tCc>tTc	p.S554F	TMC7_ENST00000304381.5_Missense_Mutation_p.S664F|TMC7_ENST00000569532.1_Missense_Mutation_p.S664F	NM_001160364.1	NP_001153836.1	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7	664						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	28						GGTGTCACATCCGAAGCCTTT	0.567000													30	65					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95522772	95522772	+	RNA	SNP	T	T	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:95522772T>C	ENST00000432432.2	-	0	255					NR_040113.1													p.E49G(1)									GCGCTCCACCTCCGCGGCGTC	0.682000													3	36					0	0	1	0	0
NDUFB4	4710	broad.mit.edu	37	3	120315211	120315211	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:120315211C>T	ENST00000485064.1	+	1	37	c.5C>T	c.(4-6)tCg>tTg	p.S2L	NDUFB4_ENST00000184266.2_Missense_Mutation_p.S2L|NDUFB4_ENST00000492739.1_Missense_Mutation_p.S2L	NM_001168331.1	NP_001161803.1	O95168	NDUB4_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa	2					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(1)|large_intestine(1)|lung(3)	5				GBM - Glioblastoma multiforme(114;0.14)	NADH(DB00157)	GCCAAGATGTCGTTCCCAAAG	0.592000													13	19					0	0	1	0	0
FOXN3	1112	broad.mit.edu	37	14	89656765	89656765	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr14:89656765C>G	ENST00000345097.4	-	5	890	c.774G>C	c.(772-774)atG>atC	p.M258I	FOXN3_ENST00000557258.1_Intron|FOXN3_ENST00000555353.1_Intron|FOXN3_ENST00000261302.5_Missense_Mutation_p.M258I	NM_001085471.1	NP_001078940.1	O00409	FOXN3_HUMAN	forkhead box N3	258					DNA damage checkpoint|embryo development|G2 phase of mitotic cell cycle|negative regulation of transcription, DNA-dependent|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein C-terminus binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TCAAAAGCATCATGGCACTGG	0.413000													13	10					0	0	1	0	0
BTAF1	9044	broad.mit.edu	37	10	93749114	93749114	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:93749114C>T	ENST00000265990.6	+	20	2939	c.2631C>T	c.(2629-2631)atC>atT	p.I877I	BTAF1_ENST00000471217.1_3'UTR	NM_003972.2	NP_003963.1	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa	877					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(2)|urinary_tract(6)	59		Colorectal(252;0.0846)				TAAATCCTATCATAAAACCAT	0.423000													11	18					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140501288	140501288	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:140501288G>C	ENST00000288602.6	-	6	844	c.784C>G	c.(784-786)Caa>Gaa	p.Q262E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	262			Q -> K (in CFC syndrome).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	CCACATGTTTGACAGCGGAAA	0.363000		61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				15	25					0	0	1	0	0
EPB41L4A	64097	broad.mit.edu	37	5	111504515	111504515	+	Nonsense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:111504515G>C	ENST00000261486.5	-	22	2129	c.1853C>G	c.(1852-1854)tCa>tGa	p.S618*	EPB41L4A_ENST00000507810.1_5'UTR	NM_022140.3	NP_071423	Q9HCS5	E41LA_HUMAN	erythrocyte membrane protein band 4.1 like 4A	618						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(2)|skin(1)	34		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		ATCTGTTTTTGAACTGCAGAG	0.388000													18	15					0	0	1	0	0
MCCC1	56922	broad.mit.edu	37	3	182810311	182810311	+	Silent	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:182810311G>C	ENST00000265594.4	-	3	305	c.159C>G	c.(157-159)ctC>ctG	p.L53L	MCCC1_ENST00000492597.1_Intron|MCCC1_ENST00000539926.1_Intron	NM_020166.3	NP_064551.3	Q96RQ3	MCCA_HUMAN	methylcrotonoyl-CoA carboxylase 1 (alpha)	53	Biotin carboxylation.				biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|liver(1)|lung(17)|ovary(1)|pancreas(2)|prostate(1)|skin(2)	40	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	TGTTTGCAATGAGGACCTTGG	0.423000													17	57					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28361860	28361860	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:28361860G>A	ENST00000261609.7	-	88	13668	c.13560C>T	c.(13558-13560)ctC>ctT	p.L4520L		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	4520	HECT.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CGGCCGGGCTGAGCAGGTAGC	0.637000													25	43					0	0	1	0	0
TM9SF4	9777	broad.mit.edu	37	20	30730905	30730905	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr20:30730905G>A	ENST00000217315.5	+	6	938	c.598G>A	c.(598-600)Gag>Aag	p.E200K	TM9SF4_ENST00000398022.2_Missense_Mutation_p.E217K			Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	217						integral to membrane		p.E200*(1)		central_nervous_system(2)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CATCAGGCTGGAGGGTGAGTG	0.617000													9	35					0	0	1	0	0
TRAF3IP2	10758	broad.mit.edu	37	6	111912473	111912473	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:111912473G>A	ENST00000368761.5	-	2	1295	c.817C>T	c.(817-819)Cac>Tac	p.H273Y	TRAF3IP2_ENST00000359831.4_Missense_Mutation_p.H273Y|TRAF3IP2_ENST00000392556.4_5'UTR|TRAF3IP2-AS1_ENST00000532353.1_RNA|TRAF3IP2_ENST00000340026.6_Missense_Mutation_p.H282Y	NM_001164281.2|NM_147686.3	NP_001157753.1|NP_679211.2	O43734	CIKS_HUMAN	TRAF3 interacting protein 2	282					intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular				central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|urinary_tract(1)	18		all_cancers(87;7.87e-06)|Acute lymphoblastic leukemia(125;3.61e-09)|all_hematologic(75;2.63e-07)|all_epithelial(87;0.0024)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.033)|all cancers(137;0.0412)|Epithelial(106;0.0732)		GGCACCTGGTGATCGGGACTT	0.512000													11	14					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39037100	39037100	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:39037100G>C	ENST00000355481.4	+	87	12144	c.12013G>C	c.(12013-12015)Gag>Cag	p.E4005Q	RYR1_ENST00000359596.3_Missense_Mutation_p.E4010Q|RYR1_ENST00000360985.3_Missense_Mutation_p.E4005Q	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	4010					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.E4010*(1)		NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AAGCCAGATCGAGCTGCTGAA	0.567000													12	29					0	0	1	0	0
KIF20B	9585	broad.mit.edu	37	10	91498741	91498741	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:91498741C>T	ENST00000416354.1	+	21	3965	c.3893C>T	c.(3892-3894)tCt>tTt	p.S1298F	KIF20B_ENST00000260753.4_Missense_Mutation_p.S1228F|KIF20B_ENST00000371728.3_Missense_Mutation_p.S1268F|KIF20B_ENST00000478929.1_3'UTR|KIF20B_ENST00000394289.2_Missense_Mutation_p.S1268F			Q96Q89	KI20B_HUMAN	kinesin family member 20B	1268					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	58						TCTGCAAGCTCTGCTCGTACC	0.388000													16	31					0	0	1	0	0
GPR108	56927	broad.mit.edu	37	19	6734200	6734200	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:6734200C>T	ENST00000264080.7	-	5	519	c.493G>A	c.(493-495)Gat>Aat	p.D165N	GPR108_ENST00000430424.4_5'UTR	NM_001080452.1	NP_001073921.1	Q9NPR9	GP108_HUMAN	G protein-coupled receptor 108	165						integral to membrane				breast(2)|cervix(1)|large_intestine(4)|lung(4)|skin(1)|urinary_tract(1)	13						TCACCGCCATCCACCTTGCGG	0.622000											OREG0025092	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	29					0	0	1	0	0
SMARCC2	6601	broad.mit.edu	37	12	56565622	56565622	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:56565622C>G	ENST00000394023.3	-	21	2131	c.2026G>C	c.(2026-2028)Gaa>Caa	p.E676Q	SMARCC2_ENST00000347471.4_Missense_Mutation_p.E676Q|SMARCC2_ENST00000267064.4_Missense_Mutation_p.E645Q|SMARCC2_ENST00000550164.1_Missense_Mutation_p.E676Q|RP11-977G19.5_ENST00000553176.1_RNA	NM_001130420.1	NP_001123892.1	Q8TAQ2	SMRC2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	645					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(18;0.123)			TATGGGTCTTCAATGGGAAGA	0.547000													18	46					0	0	1	0	0
TREML2	79865	broad.mit.edu	37	6	41162315	41162315	+	Silent	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:41162315C>G	ENST00000483722.1	-	3	818	c.633G>C	c.(631-633)gtG>gtC	p.V211V		NM_024807.2	NP_079083.2	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid cells-like 2	211					T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(13)|ovary(1)|prostate(1)	18	Ovarian(28;0.0418)|Colorectal(47;0.196)					GAGACGCGGTCACTGTCTGGG	0.617000													12	24					0	0	1	0	0
CHPT1	56994	broad.mit.edu	37	12	102091722	102091722	+	Missense_Mutation	SNP	G	G	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:102091722G>T	ENST00000549872.1	+	1	273	c.83G>T	c.(82-84)cGa>cTa	p.R28L	CHPT1_ENST00000550385.1_Intron|CHPT1_ENST00000229266.3_Missense_Mutation_p.R28L			Q8WUD6	CHPT1_HUMAN	choline phosphotransferase 1	28					platelet activating factor biosynthetic process|regulation of cell growth	Golgi membrane|integral to membrane|microsome	diacylglycerol binding|diacylglycerol cholinephosphotransferase activity|metal ion binding			kidney(2)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	10						CAGCTGCGGCGACTGGAGGAG	0.766000													4	2					3.59834e-05	3.68829e-05	1	1	0
TTBK2	146057	broad.mit.edu	37	15	43067545	43067545	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:43067545C>T	ENST00000267890.6	-	13	1894	c.1786G>A	c.(1786-1788)Gaa>Aaa	p.E596K		NM_173500.3	NP_775771.3	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	596					cell death		ATP binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	43		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		TGGAGCTTTTCATCTTGAGGT	0.463000													20	82					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198701485	198701485	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:198701485C>T	ENST00000367376.2	+	19	2196	c.2025C>T	c.(2023-2025)aaC>aaT	p.N675N	PTPRC_ENST00000348564.6_Silent_p.N516N|PTPRC_ENST00000442510.2_Silent_p.N677N|PTPRC_ENST00000352140.3_Silent_p.N627N|PTPRC_ENST00000594404.1_Silent_p.N514N	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	675	Tyrosine-protein phosphatase 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						AGCCCTTTAACCAGAATAAAA	0.383000													19	62					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32024468	32024468	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:32024468C>T	ENST00000375244.3	-	23	8239	c.8038G>A	c.(8038-8040)Ggg>Agg	p.G2680R	TNXB_ENST00000375247.2_Missense_Mutation_p.G2680R			P22105	TENX_HUMAN	tenascin XB	2740					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						ATGGTGACCCCGTCCTCGTGC	0.632000													5	56					0	0	1	0	0
C16orf71	146562	broad.mit.edu	37	16	4790489	4790489	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:4790489G>A	ENST00000299320.5	+	4	1090	c.612G>A	c.(610-612)agG>agA	p.R204R	C16orf71_ENST00000590191.1_Silent_p.R218R|RP11-127I20.7_ENST00000588099.1_RNA	NM_139170.2	NP_631909.2	Q8IYS4	CP071_HUMAN	chromosome 16 open reading frame 71	204										breast(1)|central_nervous_system(1)|large_intestine(4)|lung(4)|ovary(1)	11						AGGAGAGAAGGAAGATGATAG	0.612000													15	7					0	0	1	0	0
OR10J3	441911	broad.mit.edu	37	1	159284040	159284040	+	Missense_Mutation	SNP	A	A	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:159284040A>G	ENST00000332217.5	-	1	409	c.410T>C	c.(409-411)aTg>aCg	p.M137T		NM_001004467.1	NP_001004467.1	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J, member 3	137					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(19)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	47	all_hematologic(112;0.0429)					CCTCTTACCCATGATGACTGA	0.507000													12	94					0	0	1	0	0
YTHDC1	91746	broad.mit.edu	37	4	69195767	69195767	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr4:69195767C>T	ENST00000344157.4	-	9	1637	c.1302G>A	c.(1300-1302)atG>atA	p.M434I	YTHDC1_ENST00000355665.3_Missense_Mutation_p.M416I|YTHDC1_ENST00000579690.1_Missense_Mutation_p.M434I	NM_001031732.2	NP_001026902.1	Q96MU7	YTDC1_HUMAN	YTH domain containing 1	434	YTH.									NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	30						TTTTAGCACTCATTCCTGCTG	0.363000													65	82					0	0	1	0	0
MAN1B1	11253	broad.mit.edu	37	9	139996074	139996074	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr9:139996074C>G	ENST00000371589.4	+	8	1277	c.1204C>G	c.(1204-1206)Cag>Gag	p.Q402E	MAN1B1_ENST00000474902.1_Missense_Mutation_p.Q105E	NM_016219.4	NP_057303.2	Q9UKM7	MA1B1_HUMAN	mannosidase, alpha, class 1B, member 1	402					oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|endoplasmic reticulum quality control compartment|integral to membrane	alpha-mannosidase activity|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			autonomic_ganglia(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(2)	14	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;3.08e-05)|Epithelial(140;0.000513)		GACCAGCATTCAGCTGGAGTT	0.587000													7	6					0	0	1	0	0
NSMAF	8439	broad.mit.edu	37	8	59502625	59502625	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:59502625C>T	ENST00000038176.3	-	25	2240	c.2028G>A	c.(2026-2028)tcG>tcA	p.S676S	NSMAF_ENST00000427130.2_Silent_p.S707S	NM_003580.3	NP_003571.2	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation associated factor	676					ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	38		all_lung(136;0.174)|Lung NSC(129;0.2)				GTAAACAAGACGATAAAGCCT	0.343000													12	23					0	0	1	0	0
ZNF638	27332	broad.mit.edu	37	2	71597037	71597037	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:71597037G>C	ENST00000409544.1	+	8	2797	c.2167G>C	c.(2167-2169)Gag>Cag	p.E723Q	ZNF638_ENST00000355812.3_Missense_Mutation_p.E723Q|ZNF638_ENST00000410075.1_3'UTR|ZNF638_ENST00000264447.4_Missense_Mutation_p.E723Q|ZNF638_ENST00000377802.2_Missense_Mutation_p.E723Q	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	723	RRM 1.				RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						GGAATTTAAAGAGGCAATTAC	0.313000													10	46					0	0	1	0	0
SLC35G3	146861	broad.mit.edu	37	17	33520789	33520789	+	Missense_Mutation	SNP	G	G	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:33520789G>T	ENST00000297307.5	-	1	623	c.538C>A	c.(538-540)Cta>Ata	p.L180I		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	180						integral to membrane											CCCTCCTGTAGTGTCCAGAGT	0.587000													29	338					5.45727e-16	5.87951e-16	1	1	0
MIDN	90007	broad.mit.edu	37	19	1250394	1250394	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:1250394C>T	ENST00000300952.2	+	2	614	c.99C>T	c.(97-99)ctC>ctT	p.L33L	MIDN_ENST00000591446.2_Silent_p.L33L	NM_177401.4	NP_796375.3	Q504T8	MIDN_HUMAN	midnolin	33	Ubiquitin-like.					nucleolus				NS(1)|endometrium(3)|kidney(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ccATGAGCCTCGCCATCCACA	0.786000													4	9					0	0	1	0	0
TAF1C	9013	broad.mit.edu	37	16	84214785	84214785	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:84214785G>A	ENST00000567759.1	-	11	1432	c.1250C>T	c.(1249-1251)cCg>cTg	p.P417L	TAF1C_ENST00000341690.6_Missense_Mutation_p.P324L|TAF1C_ENST00000541676.1_Missense_Mutation_p.P324L|TAF1C_ENST00000378541.4_Missense_Mutation_p.P417L|TAF1C_ENST00000566732.1_Missense_Mutation_p.P391L|TAF1C_ENST00000570117.1_Missense_Mutation_p.P85L	NM_005679.3	NP_005670	Q15572	TAF1C_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa	417					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding			endometrium(1)|kidney(3)|large_intestine(3)|lung(11)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	26						ACCACAGCCCGGCGGGCCCTG	0.647000													16	20					0	0	1	0	0
DENND2C	163259	broad.mit.edu	37	1	115153736	115153736	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:115153736C>T	ENST00000393274.1	-	9	1952	c.1327G>A	c.(1327-1329)Gaa>Aaa	p.E443K	DENND2C_ENST00000393276.3_Missense_Mutation_p.E386K|DENND2C_ENST00000393277.1_Missense_Mutation_p.E443K|DENND2C_ENST00000481894.1_5'UTR	NM_001256404.1	NP_001243333.1	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	443										NS(2)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|skin(3)	37	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCACTGGTTTCACCTGAAAAG	0.468000													16	36					0	0	1	0	0
NOLC1	9221	broad.mit.edu	37	10	103920637	103920637	+	Nonsense_Mutation	SNP	A	A	T	rs138661407		TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:103920637A>T	ENST00000405356.1	+	10	1793	c.1558A>T	c.(1558-1560)Aag>Tag	p.K520*	NOLC1_ENST00000603742.1_Nonsense_Mutation_p.K229*|NOLC1_ENST00000477977.1_3'UTR|NOLC1_ENST00000605788.1_Nonsense_Mutation_p.K510*|NOLC1_ENST00000488254.2_Nonsense_Mutation_p.K511*	NM_001284388.1	NP_001271317.1	Q14978	NOLC1_HUMAN	nucleolar and coiled-body phosphoprotein 1	510	11 X 12 AA approximate repeats of an acidic serine cluster.				mitosis|rRNA processing	cytoplasm|nucleolus	ATP binding|GTP binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	31		Colorectal(252;0.122)		Epithelial(162;5.19e-08)|all cancers(201;9.43e-07)		AGCCTCTGCAAAGAAAGGAAA	0.522000													8	20					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12854425	12854425	+	Missense_Mutation	SNP	T	T	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:12854425T>C	ENST00000332296.7	+	3	752	c.649T>C	c.(649-651)Tgg>Cgg	p.W217R		NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	217										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CAACATGTCCTGGCCACGTCT	0.388000													92	323					0	0	1	0	0
NUCB1	4924	broad.mit.edu	37	19	49404145	49404145	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:49404145G>A	ENST00000405315.4	+	2	426	c.92G>A	c.(91-93)cGa>cAa	p.R31Q	NUCB1_ENST00000485798.1_Intron|NUCB1_ENST00000407032.1_Missense_Mutation_p.R31Q|NUCB1_ENST00000263273.5_Missense_Mutation_p.R31Q	NM_006184.5	NP_006175.2	Q02818	NUCB1_HUMAN	nucleobindin 1	31						ER-Golgi intermediate compartment|extracellular space|Golgi apparatus|membrane|microtubule cytoskeleton	calcium ion binding|DNA binding			cervix(1)|endometrium(4)|large_intestine(4)|lung(8)	17		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000171)|all cancers(93;0.000333)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0244)		CCCCTGGAGCGAGGGGCGCCC	0.662000													13	39					0	0	1	0	0
EPHX3	79852	broad.mit.edu	37	19	15342609	15342609	+	Missense_Mutation	SNP	G	G	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:15342609G>T	ENST00000221730.3	-	2	527	c.307C>A	c.(307-309)Ctg>Atg	p.L103M	EPHX3_ENST00000602233.1_Missense_Mutation_p.L103M|EPHX3_ENST00000435261.1_Missense_Mutation_p.L103M	NM_024794.2	NP_079070.1	Q9H6B9	EPHX3_HUMAN	epoxide hydrolase 3	103						extracellular region	hydrolase activity			endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)|skin(1)	7						AAGCCGTGCAGAAACAGCATG	0.662000													17	25					7.41877e-09	7.82151e-09	1	1	0
SLC27A2	11001	broad.mit.edu	37	15	50489792	50489792	+	Missense_Mutation	SNP	G	G	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:50489792G>T	ENST00000267842.5	+	2	806	c.574G>T	c.(574-576)Gac>Tac	p.D192Y	SLC27A2_ENST00000380902.4_Missense_Mutation_p.D192Y|SLC27A2_ENST00000544960.1_5'UTR	NM_003645.3	NP_003636.2	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid transporter), member 2	192					bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			NS(1)|breast(2)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		AGATGGGATTGACTCTTTCCT	0.408000													30	43					9.65021e-13	1.02768e-12	1	1	0
SRMS	6725	broad.mit.edu	37	20	62178657	62178657	+	Nonsense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr20:62178657G>A	ENST00000217188.1	-	1	200	c.160C>T	c.(160-162)Cag>Tag	p.Q54*		NM_080823.2	NP_543013.1	Q9H3Y6	SRMS_HUMAN	src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites	54	SH3.						ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|stomach(1)	19	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			AGGAAGAGCTGAGGGAAGGGG	0.721000													19	46					0	0	1	0	0
SEC14L1	6397	broad.mit.edu	37	17	75196578	75196578	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:75196578G>A	ENST00000413679.2	+	9	1135	c.832G>A	c.(832-834)Gag>Aag	p.E278K	SEC14L1_ENST00000436233.4_Missense_Mutation_p.E278K|SEC14L1_ENST00000585618.1_Missense_Mutation_p.E278K|SEC14L1_ENST00000392476.2_Missense_Mutation_p.E278K|SEC14L1_ENST00000431431.2_Missense_Mutation_p.E244K|SEC14L1_ENST00000591437.1_Missense_Mutation_p.E244K|SEC14L1_ENST00000430767.4_Missense_Mutation_p.E278K|SEC14L1_ENST00000443798.4_Missense_Mutation_p.E278K	NM_001143998.1|NM_001143999.1|NM_003003.3	NP_001137470|NP_001137471|NP_002994	Q92503	S14L1_HUMAN	SEC14-like 1 (S. cerevisiae)	278					transport	Golgi apparatus|integral to membrane	binding			NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(2)	31						TCCAAAAGATGAGCATATTCT	0.433000													21	57					0	0	1	0	0
CDH11	1009	broad.mit.edu	37	16	64984856	64984856	+	Silent	SNP	G	G	A	rs142957030		TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:64984856G>A	ENST00000394156.3	-	12	2161	c.1708C>T	c.(1708-1710)Ctg>Ttg	p.L570L	CDH11_ENST00000268603.4_Silent_p.L570L|CDH11_ENST00000566827.1_Silent_p.L444L			P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	570	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		ACTATGGGCAGAAGGTACAAG	0.612000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			11	21					0	0	1	0	0
PMCHL2	5370	broad.mit.edu	37	5	70671818	70671818	+	RNA	SNP	T	T	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:70671818T>C	ENST00000502659.2	-	0	698				PMCHL2_ENST00000450213.2_RNA																							CAGCTAAATTTCCTATAGGAA	0.373000													4	15					0	0	1	0	0
SERPINB4	6318	broad.mit.edu	37	18	61306888	61306888	+	Nonsense_Mutation	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr18:61306888C>A	ENST00000341074.5	-	6	707	c.592G>T	c.(592-594)Gaa>Taa	p.E198*	SERPINB4_ENST00000356424.6_Nonsense_Mutation_p.E198*	NM_002974.2	NP_002965.1			serpin peptidase inhibitor, clade B (ovalbumin), member 4											breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	42						CAAAATTTTTCCTCTTTAGTG	0.308000													10	15					2.17888e-05	2.23646e-05	1	1	0
RPL31P11	641311	broad.mit.edu	37	1	161654607	161654607	+	RNA	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:161654607G>A	ENST00000426558.1	-	0	435					NR_002595.1																						AACTTTATTTGATGTATTTGA	0.328000													5	6					0	0	1	0	0
POLR2A	5430	broad.mit.edu	37	17	7412359	7412359	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:7412359G>A	ENST00000322644.6	+	21	3961	c.3562G>A	c.(3562-3564)Gag>Aag	p.E1188K		NM_000937.4	NP_000928	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	1188					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				GGTGGTGGCAGAGGATCAGGA	0.547000													23	22					0	0	1	0	0
WIZ	58525	broad.mit.edu	37	19	15533949	15533949	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:15533949C>T	ENST00000389282.4	-	10	5107	c.4894G>A	c.(4894-4896)Gac>Aac	p.D1632N	WIZ_ENST00000599686.3_Missense_Mutation_p.D816N|WIZ_ENST00000263381.7_Missense_Mutation_p.D775N|WIZ_ENST00000545156.1_Missense_Mutation_p.D946N|WIZ_ENST00000599910.2_Missense_Mutation_p.D949N			O95785	WIZ_HUMAN	widely interspaced zinc finger motifs	1632						nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	24						GGTGGGGGGTCCGCTTTGGAG	0.617000													11	34					0	0	1	0	0
C16orf71	146562	broad.mit.edu	37	16	4790567	4790567	+	Silent	SNP	G	G	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:4790567G>T	ENST00000299320.5	+	4	1168	c.690G>T	c.(688-690)gtG>gtT	p.V230V	C16orf71_ENST00000590191.1_Silent_p.V244V|RP11-127I20.7_ENST00000588099.1_RNA	NM_139170.2	NP_631909.2	Q8IYS4	CP071_HUMAN	chromosome 16 open reading frame 71	230										breast(1)|central_nervous_system(1)|large_intestine(4)|lung(4)|ovary(1)	11						AAGGTGGGGTGAAGGAGGCGC	0.642000													10	12					7.48243e-07	7.79948e-07	1	1	0
PLK4	10733	broad.mit.edu	37	4	128807568	128807568	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr4:128807568G>A	ENST00000270861.5	+	5	1317	c.1043G>A	c.(1042-1044)gGa>gAa	p.G348E	PLK4_ENST00000515069.1_Missense_Mutation_p.G348E|PLK4_ENST00000507249.1_Missense_Mutation_p.G348E|PLK4_ENST00000514379.1_Missense_Mutation_p.G307E|PLK4_ENST00000513090.1_Missense_Mutation_p.G316E	NM_014264.4	NP_055079.3	O00444	PLK4_HUMAN	polo-like kinase 4	348					G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	31						ACTCAGTGGGGAAATCAAGAA	0.383000													46	50					0	0	1	0	0
USP40	55230	broad.mit.edu	37	2	234465604	234465604	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:234465604G>C	ENST00000251722.6	-	5	560	c.443C>G	c.(442-444)tCt>tGt	p.S148C	USP40_ENST00000450966.1_Missense_Mutation_p.S160C|USP40_ENST00000427112.2_Missense_Mutation_p.S148C			Q9NVE5	UBP40_HUMAN	ubiquitin specific peptidase 40	148					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(1)|endometrium(6)|kidney(5)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		CCCAACTAAAGAAGTTTCCAA	0.428000													28	16					0	0	1	0	0
GCC2	9648	broad.mit.edu	37	2	109092219	109092219	+	Silent	SNP	G	G	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:109092219G>T	ENST00000309863.6	+	9	3687	c.2973G>T	c.(2971-2973)gtG>gtT	p.V991V		NM_181453.3	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain containing 2	991					Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			breast(8)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	54						CCCAGACTGTGAAGGAAGAAC	0.333000													23	37					9.57634e-11	1.01397e-10	1	1	0
CTNNA2	1496	broad.mit.edu	37	2	80835385	80835385	+	Missense_Mutation	SNP	T	T	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:80835385T>A	ENST00000466387.1	+	21	3096	c.2372T>A	c.(2371-2373)aTc>aAc	p.I791N	AC008067.2_ENST00000430876.1_RNA|CTNNA2_ENST00000496558.1_Missense_Mutation_p.I791N|AC008067.2_ENST00000609950.1_RNA|CTNNA2_ENST00000361291.4_Missense_Mutation_p.I825N|CTNNA2_ENST00000540488.1_Intron|CTNNA2_ENST00000402739.4_Missense_Mutation_p.I791N|CTNNA2_ENST00000343114.3_Missense_Mutation_p.I470N|CTNNA2_ENST00000541047.1_Missense_Mutation_p.I791N			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	791					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						CAGCTTAATATCTGCAGCAAG	0.438000													25	35					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92534968	92534968	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:92534968G>A	ENST00000298047.6	+	9	8806	c.8789G>A	c.(8788-8790)cGa>cAa	p.R2930Q	FAT3_ENST00000525166.1_Missense_Mutation_p.R2780Q|FAT3_ENST00000409404.2_Missense_Mutation_p.R2930Q			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2930	Cadherin 27.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GAAGTGTACCGAGGGAATGTG	0.552000										TCGA Ovarian(4;0.039)			11	37					0	0	1	0	0
HIF3A	64344	broad.mit.edu	37	19	46834524	46834524	+	Silent	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:46834524C>G	ENST00000339613.2	+	13	1911	c.1656C>G	c.(1654-1656)ctC>ctG	p.L552L	HIF3A_ENST00000377670.4_Silent_p.L608L|AC007193.10_ENST00000596807.1_RNA|HIF3A_ENST00000600383.1_Silent_p.L539L|HIF3A_ENST00000300862.3_Silent_p.L606L|HIF3A_ENST00000244303.6_Silent_p.L539L|HIF3A_ENST00000420102.2_Silent_p.L557L|HIF3A_ENST00000472815.1_Intron			Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	608	ODD.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(14)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	33		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		TCTTTCCTCTCAGCCTGGTGT	0.537000													9	30					0	0	1	0	0
FBXO42	54455	broad.mit.edu	37	1	16632350	16632350	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:16632350C>T	ENST00000375592.3	-	3	531	c.315G>A	c.(313-315)gaG>gaA	p.E105E	FBXO42_ENST00000478089.1_5'UTR	NM_018994.1	NP_061867.1	Q6P3S6	FBX42_HUMAN	F-box protein 42	105										autonomic_ganglia(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	26		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)		AGGTACGGCTCTCCCACTGAA	0.478000													12	58					0	0	1	0	0
XKR6	286046	broad.mit.edu	37	8	10782178	10782178	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:10782178G>A	ENST00000416569.2	-	2	953	c.927C>T	c.(925-927)atC>atT	p.I309I	XKR6_ENST00000304437.2_Silent_p.I30I	NM_173683.3	NP_775954.2	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related family, member 6	309						integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(8)|ovary(2)|prostate(1)|skin(3)	31				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		TCTGGAGCATGATGTAGAGCT	0.652000													16	26					0	0	1	0	0
TERT	7015	broad.mit.edu	37	5	1293552	1293552	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:1293552G>A	ENST00000310581.5	-	2	1506	c.1449C>T	c.(1447-1449)aaC>aaT	p.N483N	TERT_ENST00000508104.2_Silent_p.N483N|TERT_ENST00000334602.6_Silent_p.N483N|TERT_ENST00000296820.5_Silent_p.N483N	NM_001193376.1|NM_198253.2	NP_001180305.1|NP_937983.2	O14746	TERT_HUMAN	telomerase reverse transcriptase	483	QFP motif.|RNA-interacting domain 2.|Required for oligomerization.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(3)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	41	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			AGCGGCGTTCGTTGTGCCTGG	0.662000									TERT Mutation-Associated Haematological Disorders;Pulmonary Fibrosis, Idiopathic;Congenital Dyskeratosis				7	22					0	0	1	0	0
C20orf27	54976	broad.mit.edu	37	20	3736237	3736237	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr20:3736237G>A	ENST00000379772.3	-	4	990	c.180C>T	c.(178-180)atC>atT	p.I60I	C20orf27_ENST00000217195.8_Silent_p.I85I	NM_001258429.1	NP_001245358.1	Q9GZN8	CT027_HUMAN	chromosome 20 open reading frame 27	60										central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(4)|urinary_tract(1)	7						ACCTGTGCAGGATCTTCAGGA	0.597000													11	19					0	0	1	0	0
OSBPL8	114882	broad.mit.edu	37	12	76784340	76784340	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:76784340C>G	ENST00000261183.3	-	11	1506	c.1027G>C	c.(1027-1029)Gat>Cat	p.D343H	OSBPL8_ENST00000393249.2_Missense_Mutation_p.D301H|OSBPL8_ENST00000393250.4_Missense_Mutation_p.D301H	NM_020841.4	NP_065892.1	Q9BZF1	OSBL8_HUMAN	oxysterol binding protein-like 8	343					lipid transport		lipid binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(14)|ovary(2)	28						ACCTCATTATCAGACTCATCA	0.348000													38	75					0	0	1	0	0
CD2BP2	10421	broad.mit.edu	37	16	30365963	30365963	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:30365963C>G	ENST00000305596.3	-	2	215	c.40G>C	c.(40-42)Gag>Cag	p.E14Q	CD2BP2_ENST00000569466.1_Missense_Mutation_p.E14Q	NM_006110.2	NP_006101.1	O95400	CD2B2_HUMAN	CD2 (cytoplasmic tail) binding protein 2	14					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			breast(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)	15						TCATCCTCCTCATCTCCCACG	0.527000													61	117					0	0	1	0	0
SH3BP1	23616	broad.mit.edu	37	22	38038560	38038560	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr22:38038560C>T	ENST00000599616.1	+	2	30	c.30C>T	c.(28-30)ctC>ctT	p.L10L	Z83844.1_ENST00000456099.1_RNA|SH3BP1_ENST00000357436.4_Silent_p.L74L|SH3BP1_ENST00000495174.1_3'UTR|SH3BP1_ENST00000442465.2_Silent_p.L74L|SH3BP1_ENST00000336738.5_Silent_p.L74L			Q9Y3L3	3BP1_HUMAN	SH3-domain binding protein 1	74					signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	Melanoma(58;0.0574)					AGCTTCCCCTCATGGCTCTGT	0.662000													7	16					0	0	1	0	0
CA9	768	broad.mit.edu	37	9	35674215	35674215	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr9:35674215G>A	ENST00000378357.4	+	1	363	c.259G>A	c.(259-261)Gag>Aag	p.E87K		NM_001216.2	NP_001207.2	Q16790	CAH9_HUMAN	carbonic anhydrase IX	87	Proteoglycan-like (PG).				one-carbon metabolic process	integral to membrane|microvillus membrane|nucleolus	carbonate dehydratase activity|zinc ion binding			kidney(1)|large_intestine(3)|lung(5)|ovary(4)|prostate(1)|skin(2)|urinary_tract(1)	17	all_epithelial(49;0.217)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			ACCTGGAGAGGAGGATCTACC	0.542000													17	1					0	0	1	0	0
DPP10	57628	broad.mit.edu	37	2	116503747	116503747	+	Missense_Mutation	SNP	G	G	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:116503747G>T	ENST00000410059.1	+	10	1418	c.938G>T	c.(937-939)aGc>aTc	p.S313I	DPP10_ENST00000393147.2_Missense_Mutation_p.S317I|DPP10_ENST00000310323.8_Missense_Mutation_p.S306I|DPP10_ENST00000409163.1_Missense_Mutation_p.S263I	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	313					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						CCACCTGACAGCTTTAAATCA	0.348000													23	21					1.10513e-12	1.1752e-12	1	1	0
POU6F2	11281	broad.mit.edu	37	7	39379531	39379531	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:39379531C>A	ENST00000518318.2	+	5	844	c.802C>A	c.(802-804)Cag>Aag	p.Q268K	POU6F2_ENST00000403058.1_Missense_Mutation_p.Q268K|POU6F2_ENST00000517348.1_3'UTR|POU6F2_ENST00000559001.1_Missense_Mutation_p.Q260K			P78424	PO6F2_HUMAN	POU class 6 homeobox 2	268	Gln-rich.|Pro-rich.				central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42						tccaacccagcagagctccag	0.622000													20	26					8.10497e-08	8.50849e-08	1	1	0
CD1D	912	broad.mit.edu	37	1	158151845	158151845	+	Missense_Mutation	SNP	G	G	A	rs142254126	byFrequency	TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:158151845G>A	ENST00000368171.3	+	4	851	c.352G>A	c.(352-354)Gct>Act	p.A118T		NM_001766.3	NP_001757.1	P15813	CD1D_HUMAN	CD1d molecule	118					antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(19)|ovary(1)|prostate(3)|urinary_tract(2)	30	all_hematologic(112;0.0378)					CCAGGTGTCCGCTGGCTGTGA	0.468000													6	216					0	0	1	0	0
ADAMTSL4	54507	broad.mit.edu	37	1	150526378	150526378	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:150526378C>G	ENST00000271643.4	+	6	1147	c.911C>G	c.(910-912)tCg>tGg	p.S304W	ADAMTSL4_ENST00000369038.2_Missense_Mutation_p.S304W|ADAMTSL4_ENST00000369039.5_Missense_Mutation_p.S304W|RP11-54A4.2_ENST00000442435.2_RNA|ADAMTSL4_ENST00000369041.5_Missense_Mutation_p.S304W	NM_019032.4	NP_061905.2	Q6UY14	ATL4_HUMAN	ADAMTS-like 4	304					apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			breast(1)|cervix(1)|endometrium(6)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(3)	32	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CCTTTTCCTTCGGTCCCTCGG	0.697000													7	19					0	0	1	0	0
CCDC66	285331	broad.mit.edu	37	3	56627088	56627088	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:56627088G>A	ENST00000394672.3	+	8	1097	c.1027G>A	c.(1027-1029)Gac>Aac	p.D343N	CCDC66_ENST00000436465.2_Missense_Mutation_p.D343N|CCDC66_ENST00000326595.7_Missense_Mutation_p.D309N	NM_001012506.4|NM_001141947.1	NP_001012524.4|NP_001135419.1	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66	343										breast(1)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(2)|urinary_tract(1)	12				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		AATAGAAGATGACCGTCAAAG	0.313000													29	45					0	0	1	0	0
MOB1A	55233	broad.mit.edu	37	2	74383736	74383736	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:74383736G>C	ENST00000396049.4	-	6	803	c.610C>G	c.(610-612)Ctt>Gtt	p.L204V		NM_018221.3	NP_060691.2	Q9H8S9	MOL1B_HUMAN	MOB kinase activator 1A						hippo signaling cascade		metal ion binding|protein binding										AATTCTTGAAGAGGTGCCAGC	0.328000													4	2					0	0	1	0	0
TIGD7	91151	broad.mit.edu	37	16	3350074	3350074	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:3350074C>T	ENST00000396862.1	-	2	2369	c.541G>A	c.(541-543)Gac>Aac	p.D181N	TIGD7_ENST00000268674.2_Missense_Mutation_p.D181N	NM_033208.3	NP_149985.2	Q6NT04	TIGD7_HUMAN	tigger transposable element derived 7	181	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	12						caaaagaggtctgtttcatcc	0.393000													94	67					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13429906	13429906	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:13429906G>A	ENST00000254508.5	-	5	663	c.581C>T	c.(580-582)tCa>tTa	p.S194L		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	194					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					CTCCATCTCTGAGATGTAAGA	0.507000													20	56					0	0	1	0	0
NCKAP5L	57701	broad.mit.edu	37	12	50188730	50188730	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:50188730C>T	ENST00000335999.6	-	8	3114	c.2913G>A	c.(2911-2913)ctG>ctA	p.L971L		NM_001037806.3	NP_001032895.2	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	967										central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(8)|prostate(2)	18						CCTTGGCCATCAGCTTGGAGA	0.682000													5	6					0	0	1	0	0
CTAGE1	64693	broad.mit.edu	37	18	19996516	19996516	+	Missense_Mutation	SNP	T	T	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr18:19996516T>G	ENST00000391403.2	-	1	1362	c.1259A>C	c.(1258-1260)aAg>aCg	p.K420T		NM_172241.2	NP_758441.2	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	420						integral to membrane				cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(19)|ovary(1)	27	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					AATAATCTTCTTTTGATAAAA	0.383000													20	59					0	0	1	0	0
GDF6	392255	broad.mit.edu	37	8	97156884	97156884	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:97156884C>T	ENST00000287020.5	-	2	1374	c.1275G>A	c.(1273-1275)ttG>ttA	p.L425L		NM_001001557.2	NP_001001557.1	Q6KF10	GDF6_HUMAN	growth differentiation factor 6	425					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27	Breast(36;2.67e-05)					TGATGGGAGTCAATTTGGTGG	0.607000													6	58					0	0	1	0	0
KCMF1	56888	broad.mit.edu	37	2	85270781	85270781	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:85270781G>C	ENST00000409785.4	+	4	778	c.419G>C	c.(418-420)aGa>aCa	p.R140T		NM_020122.4	NP_064507.3	Q9P0J7	KCMF1_HUMAN	potassium channel modulatory factor 1							intracellular	ligase activity|zinc ion binding			ovary(3)	3						AGAGCCCCTAGAGATTTAATA	0.398000													11	10					0	0	1	0	0
STAP2	55620	broad.mit.edu	37	19	4333775	4333775	+	Silent	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:4333775G>C	ENST00000600324.1	-	3	280	c.213C>G	c.(211-213)ctC>ctG	p.L71L	STAP2_ENST00000594605.1_Silent_p.L71L	NM_017720.2	NP_060190.2	Q9UGK3	STAP2_HUMAN	signal transducing adaptor family member 2	71	PH.					cytoplasm|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTCATCTGTGAGTTTCTCAA	0.572000													21	33					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64374863	64374863	+	Silent	SNP	G	G	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:64374863G>T	ENST00000265459.6	-	23	5405	c.4944C>A	c.(4942-4944)ctC>ctA	p.L1648L	NRXN2_ENST00000301894.2_Silent_p.L602L|NRXN2_ENST00000377559.3_Silent_p.L1578L|NRXN2_ENST00000409571.1_Silent_p.L1641L|NRXN2_ENST00000377551.1_Silent_p.L1648L	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	1648					cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						TGAGGATGCAGAGCGCCGCCG	0.652000													28	29					3.80469e-20	4.12921e-20	1	1	0
SON	6651	broad.mit.edu	37	21	34927065	34927065	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr21:34927065C>G	ENST00000356577.4	+	3	6003	c.5528C>G	c.(5527-5529)tCt>tGt	p.S1843C	SON_ENST00000290239.6_Missense_Mutation_p.S1843C|SON_ENST00000300278.4_Missense_Mutation_p.S1843C|SON_ENST00000381679.4_Missense_Mutation_p.S1843C|SON_ENST00000381692.2_Intron	NM_138927.1	NP_620305	P18583	SON_HUMAN	SON DNA binding protein	1843					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			breast(3)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(25)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	72						ACCAGTGAATCTCGTTCTAGG	0.458000													26	54					0	0	1	0	0
CD2BP2	10421	broad.mit.edu	37	16	30365991	30365991	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:30365991C>T	ENST00000305596.3	-	2	187	c.12G>A	c.(10-12)agG>agA	p.R4R	CD2BP2_ENST00000569466.1_Silent_p.R4R	NM_006110.2	NP_006101.1	O95400	CD2B2_HUMAN	CD2 (cytoplasmic tail) binding protein 2	4					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			breast(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)	15						AGGTCACTTTCCTCTTTGGCA	0.557000													52	107					0	0	1	0	0
CYCS	54205	broad.mit.edu	37	7	25163443	25163443	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:25163443C>T	ENST00000305786.2	-	3	364	c.195G>A	c.(193-195)ctG>ctA	p.L65L	CYCS_ENST00000409764.1_Silent_p.L65L|CYCS_ENST00000409409.1_Silent_p.L65L	NM_018947.5	NP_061820.1	P99999	CYC_HUMAN	cytochrome c, somatic	65					activation of caspase activity by cytochrome c|DNA fragmentation involved in apoptotic nuclear change|induction of apoptosis by intracellular signals|respiratory electron transport chain|transport	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial matrix|nucleus|protein phosphatase type 2A complex|respiratory chain	electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity|heme binding|protein binding			endometrium(1)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	4					Melatonin(DB01065)|Minocycline(DB01017)	AATACTCCATCAGTGTATCCT	0.398000													10	82					0	0	1	0	0
ZADH2	284273	broad.mit.edu	37	18	72913797	72913797	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr18:72913797C>G	ENST00000322342.3	-	2	997	c.708G>C	c.(706-708)gaG>gaC	p.E236D	ZADH2_ENST00000537114.2_Missense_Mutation_p.E113D	NM_175907.4	NP_787103.1	Q8N4Q0	ZADH2_HUMAN	zinc binding alcohol dehydrogenase domain containing 2	236						peroxisome	oxidoreductase activity|zinc ion binding			endometrium(3)|large_intestine(3)|lung(8)|skin(1)	15		Esophageal squamous(42;0.131)|Prostate(75;0.155)		READ - Rectum adenocarcinoma(2;0.0276)|BRCA - Breast invasive adenocarcinoma(31;0.216)		CTTCAGGGTACTCCTGCTTAA	0.478000													16	41					0	0	1	0	0
PRTG	283659	broad.mit.edu	37	15	55964653	55964653	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:55964653G>A	ENST00000389286.4	-	11	2078	c.2031C>T	c.(2029-2031)ctC>ctT	p.L677L		NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	677	Fibronectin type-III 3.				multicellular organismal development	integral to membrane				breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		CTAAGCCACTGAGAGTATAGA	0.438000													18	27					0	0	1	0	0
WIZ	58525	broad.mit.edu	37	19	15535113	15535113	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:15535113C>T	ENST00000389282.4	-	9	4890	c.4677G>A	c.(4675-4677)caG>caA	p.Q1559Q	WIZ_ENST00000599686.3_Silent_p.Q743Q|WIZ_ENST00000263381.7_Silent_p.Q702Q|WIZ_ENST00000545156.1_Silent_p.Q873Q|WIZ_ENST00000599910.2_Silent_p.Q876Q			O95785	WIZ_HUMAN	widely interspaced zinc finger motifs	1559						nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	24						CCTCCAGCTTCTGCTGTAGGT	0.662000													10	31					0	0	1	0	0
CCDC135	84229	broad.mit.edu	37	16	57761219	57761219	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:57761219G>A	ENST00000360716.3	+	16	2315	c.2094G>A	c.(2092-2094)gaG>gaA	p.E698E	CCDC135_ENST00000336825.8_Silent_p.E633E|CCDC135_ENST00000394337.4_Silent_p.E698E			Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	698						cytoplasm				breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						AGGTGCTGGAGATTCTGAAGC	0.552000													10	43					0	0	1	0	0
TRIM51HP	440041	broad.mit.edu	37	11	55063047	55063047	+	RNA	SNP	A	A	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:55063047A>T	ENST00000526016.1	-	0	590					NR_038174.2																						TGAGTTGCTGAAAAATGTCCT	0.418000													11	27					0	0	1	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140711554	140711554	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:140711554G>A	ENST00000517417.1	+	1	1303	c.1303G>A	c.(1303-1305)Gaa>Aaa	p.E435K	PCDHGA1_ENST00000378105.3_Missense_Mutation_p.E435K	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTATCTACTGAAACTCACAT	0.438000													37	32					0	0	1	0	0
ZNF197	10168	broad.mit.edu	37	3	44685282	44685282	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:44685282G>C	ENST00000396058.1	+	5	2827	c.2660G>C	c.(2659-2661)aGa>aCa	p.R887T	ZNF197_ENST00000383744.4_Intron|RP11-944L7.4_ENST00000457331.1_RNA|ZNF197_ENST00000383745.2_Intron|ZNF197_ENST00000344387.4_Missense_Mutation_p.R887T			O14709	ZN197_HUMAN	zinc finger protein 197	887					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(1)	25				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		ACCTCTAGTAGAAATCTTATG	0.343000													53	94					0	0	1	0	0
NT5C1B	93034	broad.mit.edu	37	2	18765807	18765807	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:18765807C>T	ENST00000304081.4	-	4	796	c.696G>A	c.(694-696)aaG>aaA	p.K232K	NT5C1B_ENST00000600945.1_Silent_p.K292K|NT5C1B_ENST00000359846.2_Silent_p.K292K|NT5C1B-RDH14_ENST00000532967.1_Silent_p.K292K	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				AGCTCGGGTTCTTCTCGTAGA	0.687000													12	11					0	0	1	0	0
MAP3K1	4214	broad.mit.edu	37	5	56178562	56178562	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:56178562G>A	ENST00000399503.3	+	14	3535	c.3535G>A	c.(3535-3537)Gag>Aag	p.E1179K		NM_005921.1	NP_005912.1	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	1179					cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			NS(1)|breast(19)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(11)|ovary(1)|skin(3)|urinary_tract(1)	57		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		AAAGTGCAAAGAGAAGATGGA	0.418000													9	31					0	0	1	0	0
ICOSLG	23308	broad.mit.edu	37	21	45655272	45655272	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr21:45655272G>A	ENST00000407780.3	-	4	707	c.580C>T	c.(580-582)Cgg>Tgg	p.R194W	ICOSLG_ENST00000344330.4_Missense_Mutation_p.R194W|ICOSLG_ENST00000400377.3_Missense_Mutation_p.R77W|ICOSLG_ENST00000400379.3_Missense_Mutation_p.R194W	NM_001283052.1	NP_001269981.1	O75144	ICOSL_HUMAN	inducible T-cell co-stimulator ligand	194	Ig-like C2-type.				B cell activation|defense response|hyperosmotic response|positive regulation of activated T cell proliferation|signal transduction|T cell activation|T cell costimulation		receptor binding			endometrium(2)|lung(1)|stomach(1)|urinary_tract(1)	5				Colorectal(79;0.0163)|READ - Rectum adenocarcinoma(84;0.0772)		TACAAGCCCCGCATGTTCAAG	0.562000													10	10					0	0	1	0	0
GLYATL2	219970	broad.mit.edu	37	11	58604522	58604522	+	Missense_Mutation	SNP	T	T	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:58604522T>C	ENST00000287275.1	-	5	832	c.442A>G	c.(442-444)Aag>Gag	p.K148E	GLYATL2_ENST00000532258.1_Missense_Mutation_p.K148E|GLYATL2_ENST00000533636.1_5'UTR	NM_145016.3	NP_659453.3	Q8WU03	GLYL2_HUMAN	glycine-N-acyltransferase-like 2	148						mitochondrion	glycine N-acyltransferase activity			breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	23		Breast(21;0.0044)|all_epithelial(135;0.0216)			Glycine(DB00145)	AACTCCATCTTGTCATTACTT	0.368000													31	39					0	0	1	0	0
C6orf47	57827	broad.mit.edu	37	6	31627422	31627422	+	Silent	SNP	T	T	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:31627422T>C	ENST00000375911.1	-	1	1127	c.303A>G	c.(301-303)caA>caG	p.Q101Q	C6orf47-AS1_ENST00000422049.1_RNA	NM_021184.3	NP_067007.3	O95873	CF047_HUMAN	chromosome 6 open reading frame 47	101										NS(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	9						TCCCAGACTCTTGAGTGCTAG	0.582000													50	61					0	0	1	0	0
ARPC5	10092	broad.mit.edu	37	1	183599721	183599721	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:183599721C>G	ENST00000359856.6	-	3	334	c.268G>C	c.(268-270)Gat>Cat	p.D90H	ARPC5_ENST00000294742.6_Missense_Mutation_p.D93H|ARPC5_ENST00000367534.1_Missense_Mutation_p.D90H|ARPC5_ENST00000462965.1_5'UTR	NM_005717.3	NP_005708.1	O15511	ARPC5_HUMAN	actin related protein 2/3 complex, subunit 5, 16kDa	90					actin cytoskeleton organization|cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cell projection|cytoplasm	actin binding|structural constituent of cytoskeleton			cervix(1)|large_intestine(1)|lung(2)	4						TTTTCTATATCATTAGCTTTA	0.408000													55	56					0	0	1	0	0
BDP1	55814	broad.mit.edu	37	5	70838002	70838002	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:70838002G>C	ENST00000358731.4	+	30	6585	c.6322G>C	c.(6322-6324)Gag>Cag	p.E2108Q	BDP1_ENST00000380675.2_Missense_Mutation_p.E244Q	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	2108					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		ACCAAATCTTGAGAAGACTTT	0.353000													12	29					0	0	1	0	0
SERPINA3	12	broad.mit.edu	37	14	95081112	95081112	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr14:95081112G>C	ENST00000467132.1	+	2	1482	c.334G>C	c.(334-336)Gag>Cag	p.E112Q	RP11-986E7.7_ENST00000553947.1_3'UTR|SERPINA3_ENST00000393078.3_Missense_Mutation_p.E112Q|SERPINA3_ENST00000393080.4_Missense_Mutation_p.E112Q			P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	112					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(17)|ovary(2)|pancreas(1)|skin(3)|stomach(1)	40		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		GGAGACTTCTGAGGCAGAAAT	0.537000													22	14					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128910856	128910856	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:128910856G>A	ENST00000310343.9	-	10	969	c.970C>T	c.(970-972)Ccc>Tcc	p.P324S	ARHGAP32_ENST00000524655.1_Missense_Mutation_p.P250S	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	324					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						ACTGACTGGGGAACTTTTTGG	0.398000													3	8					0	0	1	0	0
MGEA5	10724	broad.mit.edu	37	10	103557853	103557853	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:103557853C>G	ENST00000361464.3	-	10	2263	c.1868G>C	c.(1867-1869)gGa>gCa	p.G623A	MGEA5_ENST00000357797.5_Missense_Mutation_p.G570A|MGEA5_ENST00000482611.1_5'UTR|MGEA5_ENST00000370094.3_Missense_Mutation_p.G623A|MGEA5_ENST00000439817.1_Missense_Mutation_p.G570A	NM_012215.3	NP_036347.1	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	623	Histone acetyltransferase activity (By similarity).				glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	23		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		AGTGAACATTCCCATCACTAG	0.393000													15	30					0	0	1	0	0
CDK4	1019	broad.mit.edu	37	12	58145447	58145447	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:58145447C>T	ENST00000257904.6	-	2	419	c.54G>A	c.(52-54)ggG>ggA	p.G18G	CDK4_ENST00000540325.1_5'UTR|CDK4_ENST00000551888.1_5'UTR|CDK4_ENST00000312990.6_Silent_p.G18G|CDK4_ENST00000549606.1_Intron	NM_000075.3	NP_000066.1	P11802	CDK4_HUMAN	cyclin-dependent kinase 4	18	Protein kinase.				cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|positive regulation of fibroblast proliferation|regulation of gene expression|response to drug|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane	ATP binding|cyclin-dependent protein kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(2)	21	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			TGTACACTGTCCCATAGGCAC	0.542000			Mis			melanoma			Hereditary Melanoma				13	36					0	0	1	0	0
SERPINF2	5345	broad.mit.edu	37	17	1657609	1657609	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:1657609C>T	ENST00000324015.3	+	10	1334	c.1257C>T	c.(1255-1257)atC>atT	p.I419I	SERPINF2_ENST00000382061.4_Silent_p.I419I|SERPINF2_ENST00000450523.2_Silent_p.I355I	NM_000934.3	NP_000925.2	P08697	A2AP_HUMAN	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	419					acute-phase response|fibrinolysis|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			breast(2)|endometrium(1)|kidney(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)	Streptokinase(DB00086)	TCTTCTTCATCTTCGAGGACA	0.652000													44	46					0	0	1	0	0
SULF1	23213	broad.mit.edu	37	8	70551080	70551080	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:70551080G>C	ENST00000260128.4	+	21	3255	c.2538G>C	c.(2536-2538)aaG>aaC	p.K846N	SULF1_ENST00000521946.1_3'UTR|SULF1_ENST00000402687.4_Missense_Mutation_p.K846N|SULF1_ENST00000419716.3_Missense_Mutation_p.K846N|SULF1_ENST00000458141.2_Missense_Mutation_p.K846N	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	846					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			CAAGACCTAAGAATCTTGATG	0.383000													7	107					0	0	1	0	0
OR1S2	219958	broad.mit.edu	37	11	57971084	57971084	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:57971084G>C	ENST00000302592.6	-	1	569	c.570C>G	c.(568-570)ttC>ttG	p.F190L		NM_001004459.1	NP_001004459.1	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S, member 2	190					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(11)|kidney(1)|large_intestine(4)|lung(23)|ovary(2)|skin(2)|stomach(2)|urinary_tract(1)	46		Breast(21;0.0589)				AGTCACAGAAGAAGTGTGGGA	0.433000													32	75					0	0	1	0	0
C12orf65	91574	broad.mit.edu	37	12	123741500	123741500	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:123741500G>C	ENST00000253233.1	+	3	1067	c.423G>C	c.(421-423)agG>agC	p.R141S	C12orf65_ENST00000366329.2_Missense_Mutation_p.R141S|RP11-282O18.3_ENST00000541002.3_RNA|RP11-282O18.3_ENST00000543217.2_RNA|C12orf65_ENST00000429587.2_Missense_Mutation_p.R141S	NM_152269.4	NP_689482.1	Q9H3J6	CL065_HUMAN	chromosome 12 open reading frame 65	141						mitochondrion	translation release factor activity			endometrium(1)|large_intestine(1)|lung(1)|prostate(1)	4	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000595)|Epithelial(86;0.00199)		aacaagaaaggaaaaaaagag	0.373000													32	17					0	0	1	0	0
COG3	83548	broad.mit.edu	37	13	46054311	46054311	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr13:46054311G>A	ENST00000349995.5	+	4	547	c.435G>A	c.(433-435)ttG>ttA	p.L145L		NM_031431.3	NP_113619	Q96JB2	COG3_HUMAN	component of oligomeric golgi complex 3	145					ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein glycosylation|protein localization to organelle|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	cis-Golgi network|Golgi cisterna membrane|Golgi transport complex	protein binding|protein transporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|skin(2)|stomach(1)	24		Lung NSC(96;0.000145)|Breast(56;0.000596)|Prostate(109;0.00438)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000124)		ATGCTATATTGAATGATGTAA	0.418000													7	57					0	0	1	0	0
DHTKD1	55526	broad.mit.edu	37	10	12159712	12159712	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:12159712C>T	ENST00000263035.4	+	14	2422	c.2360C>T	c.(2359-2361)aCa>aTa	p.T787I		NM_018706.5	NP_061176	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain containing 1	787					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(1)	44		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			CCAGGAACAACATTTAACCCG	0.423000													69	64					0	0	1	0	0
PDILT	204474	broad.mit.edu	37	16	20387489	20387489	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:20387489C>G	ENST00000302451.4	-	4	692	c.444G>C	c.(442-444)ttG>ttC	p.L148F		NM_174924.1	NP_777584.1	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis expressed	148					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(33)|prostate(3)|skin(1)|urinary_tract(1)	61						TTTGTCGTCTCAACCAAACGA	0.468000													15	36					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167163052	167163052	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:167163052C>T	ENST00000303354.6	-	4	778	c.438G>A	c.(436-438)atG>atA	p.M146I	SCN9A_ENST00000409435.1_Missense_Mutation_p.M145I|SCN9A_ENST00000409672.1_Missense_Mutation_p.M145I|SCN9A_ENST00000375387.4_Missense_Mutation_p.M146I			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	145						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	GTGGGTTATTCATGGTCATAA	0.373000													6	5					0	0	1	0	0
TAS2R20	259295	broad.mit.edu	37	12	11149907	11149907	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:11149907G>C	ENST00000538986.1	-	1	567	c.568C>G	c.(568-570)Ctg>Gtg	p.L190V	TAS2R14_ENST00000381852.4_Intron|PRR4_ENST00000536668.1_Intron	NM_176889.2	NP_795370.2	P59543	T2R20_HUMAN	taste receptor, type 2, member 20	190					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13						ATCAGGGTCAGAGTGAATGGT	0.423000													37	56					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33338261	33338261	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr20:33338261C>T	ENST00000374796.2	-	10	4307	c.1737G>A	c.(1735-1737)atG>atA	p.M579I	NCOA6_ENST00000359003.2_Missense_Mutation_p.M579I			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	579	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						TGGGCTGCATCATATTTGGCG	0.478000													32	57					0	0	1	0	0
GEMIN2	8487	broad.mit.edu	37	14	39583576	39583576	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr14:39583576G>C	ENST00000308317.6	+	1	150	c.67G>C	c.(67-69)Gag>Cag	p.E23Q	GEMIN2_ENST00000396249.2_Missense_Mutation_p.E23Q|GEMIN2_ENST00000250379.8_Missense_Mutation_p.E23Q	NM_003616.2	NP_003607.1	O14893	GEMI2_HUMAN	gem (nuclear organelle) associated protein 2	23					ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly	Cajal body|cytosol|spliceosomal complex	protein binding										CGCAGTGGAAGAGTTGATGCC	0.602000													15	8					0	0	1	0	0
UVSSA	57654	broad.mit.edu	37	4	1346886	1346886	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr4:1346886G>C	ENST00000389851.4	+	5	1066	c.619G>C	c.(619-621)Gac>Cac	p.D207H	UVSSA_ENST00000507531.1_Missense_Mutation_p.D207H|UVSSA_ENST00000511216.1_Missense_Mutation_p.D207H	NM_020894.2	NP_065945.2	Q2YD98	K1530_HUMAN	UV-stimulated scaffold protein A	207																	GGTGCCTTTTGACTTTGACCC	0.587000													14	42					0	0	1	0	0
MAN1B1	11253	broad.mit.edu	37	9	139996096	139996096	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr9:139996096C>G	ENST00000371589.4	+	8	1299	c.1226C>G	c.(1225-1227)tCc>tGc	p.S409C	MAN1B1_ENST00000474902.1_Missense_Mutation_p.S112C	NM_016219.4	NP_057303.2	Q9UKM7	MA1B1_HUMAN	mannosidase, alpha, class 1B, member 1	409					oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|endoplasmic reticulum quality control compartment|integral to membrane	alpha-mannosidase activity|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			autonomic_ganglia(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(2)	14	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;3.08e-05)|Epithelial(140;0.000513)		CGGGAGCTCTCCCGTCTCACA	0.592000													6	6					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17007033	17007033	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:17007033C>G	ENST00000443236.1	-	41	5552	c.5521G>C	c.(5521-5523)Gag>Cag	p.E1841Q	CPAMD8_ENST00000597335.1_5'UTR	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	1794						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						TCCTCCACCTCAAGGCCGGCT	0.632000													15	37					0	0	1	0	0
KCNE1	3753	broad.mit.edu	37	21	35821726	35821726	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr21:35821726C>T	ENST00000337385.3	-	3	582	c.207G>A	c.(205-207)aaG>aaA	p.K69K	KCNE1_ENST00000416357.2_Silent_p.K69K|KCNE1_ENST00000399286.2_Silent_p.K69K|KCNE1_ENST00000432085.1_Silent_p.K69K|KCNE1_ENST00000399289.3_Silent_p.K69K|KCNE1_ENST00000399284.1_Silent_p.K69K	NM_001270402.1|NM_001270403.1	NP_001257331.1|NP_001257332.1	P15382	KCNE1_HUMAN	potassium voltage-gated channel, Isk-related family, member 1	69					blood circulation|membrane depolarization|muscle contraction|sensory perception of sound	lysosome	delayed rectifier potassium channel activity|potassium channel regulator activity			large_intestine(4)|lung(1)|ovary(2)	7					Indapamide(DB00808)	GCTCCAGCTTCTTGGAGCGGA	0.582000													16	26					0	0	1	0	0
GPR108	56927	broad.mit.edu	37	19	6734291	6734291	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:6734291C>G	ENST00000264080.7	-	5	428	c.402G>C	c.(400-402)caG>caC	p.Q134H	GPR108_ENST00000430424.4_5'UTR	NM_001080452.1	NP_001073921.1	Q9NPR9	GP108_HUMAN	G protein-coupled receptor 108	134						integral to membrane				breast(2)|cervix(1)|large_intestine(4)|lung(4)|skin(1)|urinary_tract(1)	13						ACAACGTCTTCTGCTCTCCAT	0.642000											OREG0025092	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	16					0	0	1	0	0
EIF3L	51386	broad.mit.edu	37	22	38251592	38251592	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr22:38251592G>C	ENST00000412331.2	+	4	896	c.314G>C	c.(313-315)aGa>aCa	p.R105T	EIF3L_ENST00000476955.1_Intron|EIF3L_ENST00000406934.1_Intron|EIF3L_ENST00000381683.6_Missense_Mutation_p.R105T	NM_016091.3	NP_057175.1	Q9Y262	EIF3L_HUMAN	eukaryotic translation initiation factor 3, subunit L	105						eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			kidney(2)|large_intestine(3)|lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						CTGACTGAAAGATTCTTCAAG	0.428000													9	36					0	0	1	0	0
ZFP57	346171	broad.mit.edu	37	6	29640381	29640381	+	Missense_Mutation	SNP	G	G	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:29640381G>T	ENST00000376883.1	-	6	1858	c.1447C>A	c.(1447-1449)Caa>Aaa	p.Q483K	ZFP57_ENST00000488757.1_Missense_Mutation_p.Q503K|ZFP57_ENST00000376881.3_Missense_Mutation_p.Q483K			Q9NU63	ZFP57_HUMAN	ZFP57 zinc finger protein	419					DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(16)|ovary(4)|skin(4)|urinary_tract(5)	44						GGGGGAGATTGATCACCTCCA	0.537000													17	79					9.7654e-05	9.99565e-05	1	1	0
TEC	7006	broad.mit.edu	37	4	48178119	48178119	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr4:48178119G>C	ENST00000381501.3	-	3	380	c.223C>G	c.(223-225)Caa>Gaa	p.Q75E		NM_003215.2	NP_003206.2	P42680	TEC_HUMAN	tec protein tyrosine kinase	75	PH.				intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(2)|skin(2)|stomach(1)	31						TACTTATTTTGACAGGGAATG	0.373000													42	88					0	0	1	0	0
HSPA4	3308	broad.mit.edu	37	5	132427025	132427025	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:132427025G>A	ENST00000304858.2	+	12	1808	c.1519G>A	c.(1519-1521)Gag>Aag	p.E507K		NM_002154.3	NP_002145.3	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	507					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(10)|stomach(1)	32			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGAGGAAAATGAGGAGCCAAT	0.423000													13	39					0	0	1	0	0
VEGFC	7424	broad.mit.edu	37	4	177713370	177713370	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr4:177713370G>A	ENST00000280193.2	-	1	511	c.96C>T	c.(94-96)ttC>ttT	p.F32F		NM_005429.2	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	32					angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			biliary_tract(1)|cervix(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(2)|skin(2)	41		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		GTCCGGACTCGAAggcggcgg	0.692000													4	12					0	0	1	0	0
CHD1	1105	broad.mit.edu	37	5	98229235	98229235	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:98229235G>C	ENST00000284049.3	-	13	2025	c.1876C>G	c.(1876-1878)Ctg>Gtg	p.L626V		NM_001270.2	NP_001261.2	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	626	Helicase ATP-binding.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(2)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	49		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	GTTTTATACAGAAGGGAGTCA	0.353000													41	55					0	0	1	0	0
TSR2	90121	broad.mit.edu	37	X	54470498	54470498	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chrX:54470498C>G	ENST00000375151.4	+	4	343	c.322C>G	c.(322-324)Ctg>Gtg	p.L108V		NM_058163.1	NP_477511.1	Q969E8	TSR2_HUMAN	TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)	108					rRNA processing		protein binding			breast(1)|endometrium(3)|lung(2)	6						TGGGGCTGCTCTGAGGGAGAT	0.488000													13	12					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23914843	23914843	+	Missense_Mutation	SNP	T	T	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr13:23914843T>A	ENST00000382298.3	-	10	3760	c.3172A>T	c.(3172-3174)Ata>Tta	p.I1058L	SACS_ENST00000402364.1_Missense_Mutation_p.I308L|SACS_ENST00000382292.3_Missense_Mutation_p.I1058L	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	1058					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AGTACTTCTATATCAGGGTCA	0.383000													29	76					0	0	1	0	0
MCM7	4176	broad.mit.edu	37	7	99697218	99697218	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:99697218C>T	ENST00000303887.5	-	3	915	c.270G>A	c.(268-270)gaG>gaA	p.E90E	MCM7_ENST00000343023.6_Silent_p.E90E|MCM7_ENST00000354230.3_5'UTR	NM_005916.3	NP_005907.3	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	90					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding	p.E90D(1)		endometrium(1)|kidney(5)|large_intestine(5)|lung(4)|ovary(1)|stomach(1)	17	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	TCACTTCCCTCTCCTTGTACT	0.512000													40	73					0	0	1	0	0
DDHD1	80821	broad.mit.edu	37	14	53513497	53513497	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr14:53513497C>T	ENST00000357758.3	-	12	2791	c.2608G>A	c.(2608-2610)Gat>Aat	p.D870N	DDHD1_ENST00000323669.5_Missense_Mutation_p.D898N|DDHD1_ENST00000395606.1_Missense_Mutation_p.D877N	NM_030637.2	NP_085140.2	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1	898	DDHD.				lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)	25	Breast(41;0.037)					CAGATTGGATCTAAATTGGGT	0.378000													11	28					0	0	1	0	0
ZNF229	7772	broad.mit.edu	37	19	44933651	44933651	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:44933651G>A	ENST00000291187.4	-	6	1609	c.1287C>T	c.(1285-1287)tgC>tgT	p.C429C	ZNF229_ENST00000588931.1_Silent_p.C435C|CTC-512J12.4_ENST00000588655.1_RNA|ZNF229_ENST00000591289.1_Intron	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	435					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				CACACTCGCTGCAGGTGTAGG	0.537000													3	48					0	0	1	0	0
WIZ	58525	broad.mit.edu	37	19	15535124	15535124	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:15535124C>T	ENST00000389282.4	-	9	4879	c.4666G>A	c.(4666-4668)Gac>Aac	p.D1556N	WIZ_ENST00000599686.3_Missense_Mutation_p.D740N|WIZ_ENST00000263381.7_Missense_Mutation_p.D699N|WIZ_ENST00000545156.1_Missense_Mutation_p.D870N|WIZ_ENST00000599910.2_Missense_Mutation_p.D873N			O95785	WIZ_HUMAN	widely interspaced zinc finger motifs	1556						nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	24						TGCTGTAGGTCATTGGTGTCC	0.657000													16	33					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29677228	29677228	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:29677228G>A	ENST00000358273.4	+	50	7732	c.7349G>A	c.(7348-7350)cGa>cAa	p.R2450Q	NF1_ENST00000444181.2_Missense_Mutation_p.R243Q|NF1_ENST00000356175.3_Missense_Mutation_p.R2429Q|NF1_ENST00000417592.2_Missense_Mutation_p.R163Q	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	2450					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(3)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GAAGAAGTTCGAAGTCGCTGC	0.363000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			23	129					0	0	1	0	0
RBCK1	10616	broad.mit.edu	37	20	408112	408112	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr20:408112C>T	ENST00000356286.5	+	9	1890	c.1185C>T	c.(1183-1185)ttC>ttT	p.F395F	RBCK1_ENST00000382181.2_Silent_p.F225F|RBCK1_ENST00000353660.3_Silent_p.F353F	NM_031229.2	NP_112506.2	Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing 1	395					interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|lung(4)	5		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)				CTGTGTGTTTCCACGTCAACT	0.552000													16	43					0	0	1	0	0
MIR518A2	574491	broad.mit.edu	37	19	54242621	54242621	+	RNA	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:54242621C>G	ENST00000384966.1	+	0	35					NR_030213.1																						GAAGCCCTTTCTGTTGTCTAA	0.453000													30	113					0	0	1	0	0
OR4M2	390538	broad.mit.edu	37	15	22368920	22368920	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:22368920C>T	ENST00000332663.2	+	1	443	c.345C>T	c.(343-345)ctC>ctT	p.L115L	RP11-69H14.6_ENST00000558896.1_RNA	NM_001004719.2	NP_001004719.2	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M, member 2	115					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(38)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	63		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TGTTCTTGCTCACAGTGATGG	0.473000													22	143					0	0	1	0	0
TNRC18	84629	broad.mit.edu	37	7	5391485	5391485	+	Missense_Mutation	SNP	G	G	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:5391485G>T	ENST00000399537.4	-	17	5783	c.5435C>A	c.(5434-5436)tCc>tAc	p.S1812Y	TNRC18_ENST00000430969.1_Missense_Mutation_p.S1812Y			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	1812							DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		GTCGCTGAAGGAGGAACGCGC	0.592000													19	13					8.00594e-06	8.27505e-06	1	1	0
NOP14	8602	broad.mit.edu	37	4	2940930	2940930	+	Nonsense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr4:2940930G>C	ENST00000416614.2	-	17	2524	c.2459C>G	c.(2458-2460)tCa>tGa	p.S820*	NOP14-AS1_ENST00000507999.1_RNA|NOP14-AS1_ENST00000512712.2_RNA|NOP14-AS1_ENST00000505731.1_RNA|NOP14-AS1_ENST00000503709.1_RNA|NOP14_ENST00000398071.4_Intron|NOP14_ENST00000502735.1_Intron|NOP14_ENST00000314262.6_Nonsense_Mutation_p.S820*|NOP14-AS1_ENST00000507702.1_RNA|NOP14-AS1_ENST00000515194.1_RNA|NOP14-AS1_ENST00000512802.1_RNA|NOP14_ENST00000507120.1_Intron			P78316	NOP14_HUMAN	NOP14 nucleolar protein	820					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(9)|lung(12)|pancreas(1)|skin(1)|urinary_tract(1)	30						CATGATTTCTGAGAGTTGCAT	0.552000													32	158					0	0	1	0	0
VSTM1	284415	broad.mit.edu	37	19	54545204	54545204	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:54545204G>A	ENST00000338372.2	-	7	694	c.519C>T	c.(517-519)acC>acT	p.T173T	VSTM1_ENST00000366170.2_Silent_p.T85T|VSTM1_ENST00000376626.1_Silent_p.T142T|VSTM1_ENST00000425006.2_3'UTR	NM_198481.3	NP_940883.2	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	173						integral to membrane				breast(1)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		TGGAATGGCTGGTTCTGAAAG	0.532000													9	55					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168110619	168110619	+	Nonsense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:168110619C>T	ENST00000409195.1	+	10	10722	c.10633C>T	c.(10633-10635)Caa>Taa	p.Q3545*	XIRP2_ENST00000409273.1_Nonsense_Mutation_p.Q3323*|XIRP2_ENST00000409605.1_Silent_p.D196D|XIRP2_ENST00000420519.1_Silent_p.D451D|XIRP2_ENST00000409728.1_Silent_p.D451D|XIRP2_ENST00000295237.9_Nonsense_Mutation_p.Q3545*|XIRP2_ENST00000409043.1_Silent_p.D418D|XIRP2_ENST00000409756.2_Silent_p.D418D	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	3370					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TAGTGGCAGACAAGCAGAATT	0.378000													13	33					0	0	1	0	0
MRPL3	11222	broad.mit.edu	37	3	131217058	131217058	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:131217058G>C	ENST00000264995.3	-	4	580	c.433C>G	c.(433-435)Ctg>Gtg	p.L145V	MRPL3_ENST00000425847.2_Missense_Mutation_p.L172V|MRPL3_ENST00000506946.1_5'UTR	NM_007208.3	NP_009139.1	P09001	RM03_HUMAN	mitochondrial ribosomal protein L3	145					translation	mitochondrial large ribosomal subunit	RNA binding|structural constituent of ribosome			endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	10						CCTACAGACAGGGTTGCCATT	0.333000													8	60					0	0	1	0	0
BICC1	80114	broad.mit.edu	37	10	60549213	60549213	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:60549213G>A	ENST00000373886.3	+	7	796	c.792G>A	c.(790-792)gtG>gtA	p.V264V		NM_001080512.1	NP_001073981.1	Q9H694	BICC1_HUMAN	bicaudal C homolog 1 (Drosophila)	264					multicellular organismal development		RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	44						CTAGTGCTGTGAAGGTAAATT	0.328000													20	52					0	0	1	0	0
ZNF436	80818	broad.mit.edu	37	1	23688504	23688504	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:23688504C>G	ENST00000314011.4	-	4	1507	c.1371G>C	c.(1369-1371)agG>agC	p.R457S	ZNF436_ENST00000374608.3_Missense_Mutation_p.R457S	NM_001077195.1	NP_001070663.1	Q9C0F3	ZN436_HUMAN	zinc finger protein 436	457					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	19		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;5.97e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000977)|KIRC - Kidney renal clear cell carcinoma(1967;0.00336)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		GAGCTGAGCTCCTGCTGAAAC	0.388000													17	91					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577099	7577099	+	Missense_Mutation	SNP	C	C	T	rs121912660		TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:7577099C>T	ENST00000420246.2	-	8	971	c.839G>A	c.(838-840)aGa>aAa	p.R280K	TP53_ENST00000359597.4_Missense_Mutation_p.R280K|TP53_ENST00000269305.4_Missense_Mutation_p.R280K|TP53_ENST00000413465.2_Intron|TP53_ENST00000455263.2_Missense_Mutation_p.R280K|TP53_ENST00000445888.2_Missense_Mutation_p.R280K	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	280	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		R -> G (in sporadic cancers; somatic mutation).|R -> I (in sporadic cancers; somatic mutation).|R -> K (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in a sporadic cancer; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R280T(65)|p.R280K(49)|p.R280I(16)|p.0?(8)|p.?(2)|p.R280_D281delRD(2)|p.A276_R283delACPGRDRR(1)|p.C275fs*20(1)|p.A276fs*64(1)|p.L265_K305del41(1)|p.G279_R280delGR(1)|p.F270_D281del12(1)|p.G279fs*59(1)|p.D281fs*24(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.V272_K292del21(1)|p.C275_R283delCACPGRDRR(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCGCCGGTCTCTCCCAGGACA	0.542000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			17	11					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57573143	57573143	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:57573143G>C	ENST00000243077.3	+	29	5236	c.4770G>C	c.(4768-4770)caG>caC	p.Q1590H		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	1590					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	ACGCACGTCAGATGGAGATCC	0.552000													7	17					0	0	1	0	0
ZNF229	7772	broad.mit.edu	37	19	44933732	44933732	+	Silent	SNP	G	G	A	rs145520471	by1000genomes	TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:44933732G>A	ENST00000291187.4	-	6	1528	c.1206C>T	c.(1204-1206)agC>agT	p.S402S	ZNF229_ENST00000588931.1_Silent_p.S408S|CTC-512J12.4_ENST00000588655.1_RNA|ZNF229_ENST00000591289.1_Intron	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	408					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				TCCCACACTCGCTGCATTTAT	0.522000													16	49					0	0	1	0	0
CLCA2	9635	broad.mit.edu	37	1	86920977	86920977	+	Nonsense_Mutation	SNP	C	C	T	rs150119696		TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:86920977C>T	ENST00000370565.4	+	14	2761	c.2599C>T	c.(2599-2601)Cga>Tga	p.R867*		NM_006536.5	NP_006527.1	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2	867					cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			NS(2)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	42		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		TGTTGCAATACGAGCAATGGA	0.448000													36	110					0	0	1	0	0
ADH7	131	broad.mit.edu	37	4	100349145	100349145	+	Splice_Site	SNP	T	T	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr4:100349145T>C	ENST00000437033.2	-	5	852	c.349A>G	c.(349-351)Att>Gtt	p.I117V	ADH7_ENST00000482593.1_Splice_Site_p.I60V|ADH7_ENST00000209665.4_Splice_Site_p.I129V|ADH7_ENST00000476959.1_Splice_Site_p.I137V			P40394	ADH7_HUMAN	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	129					ethanol oxidation|fatty acid omega-oxidation|response to bacterium|response to ethanol|xenobiotic metabolic process	cytosol|soluble fraction	alcohol dehydrogenase activity, zinc-dependent|aldehyde oxidase activity|ethanol binding|receptor antagonist activity|retinol binding|retinol dehydrogenase activity			breast(1)|central_nervous_system(2)|large_intestine(4)|lung(11)|skin(1)	19				OV - Ovarian serous cystadenocarcinoma(123;1.75e-08)	NADH(DB00157)	CGACCAGTAATACTGTTTGAT	0.363000													17	70					0	0	1	0	0
PFKL	5211	broad.mit.edu	37	21	45725780	45725780	+	Nonsense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr21:45725780C>G	ENST00000403390.1	+	2	188	c.188C>G	c.(187-189)tCa>tGa	p.S63*	PFKL_ENST00000496824.1_Intron|PFKL_ENST00000349048.4_Intron			P17858	K6PL_HUMAN	phosphofructokinase, liver	0					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	23				Colorectal(79;0.0811)		GAAGTGACCTCAGAGCCTGGT	0.647000													6	10					0	0	1	0	0
SPTBN5	51332	broad.mit.edu	37	15	42148610	42148610	+	Nonsense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:42148610G>A	ENST00000320955.6	-	53	9222	c.8995C>T	c.(8995-8997)Cag>Tag	p.Q2999*		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	2999					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		TGGGCCTCCTGAGCCTGCTGC	0.701000													4	9					0	0	1	0	0
FBXW4	6468	broad.mit.edu	37	10	103433254	103433254	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:103433254C>T	ENST00000331272.7	-	3	1151	c.533G>A	c.(532-534)aGt>aAt	p.S178N		NM_022039.3	NP_071322.1	P57775	FBXW4_HUMAN	F-box and WD repeat domain containing 4	178					ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	ubiquitin ligase complex				breast(3)|endometrium(2)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	15		Colorectal(252;0.123)		Epithelial(162;4.35e-08)|all cancers(201;1.92e-06)		CCCTCCTGCACTAACAATATG	0.502000													31	82					0	0	1	0	0
KIF5A	3798	broad.mit.edu	37	12	57975342	57975342	+	Nonsense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:57975342C>G	ENST00000455537.2	+	25	3174	c.2900C>G	c.(2899-2901)tCa>tGa	p.S967*	KIF5A_ENST00000286452.5_Nonsense_Mutation_p.S878*	NM_004984.2	NP_004975.2	Q12840	KIF5A_HUMAN	kinesin family member 5A	967	Globular.				blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(32)|ovary(2)|prostate(2)|skin(2)	62						AGCTCCACCTCAGATATGTAG	0.557000													13	23					0	0	1	0	0
PPRC1	23082	broad.mit.edu	37	10	103909703	103909703	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:103909703G>A	ENST00000278070.2	+	14	4951	c.4912G>A	c.(4912-4914)Gac>Aac	p.D1638N	PPRC1_ENST00000370012.1_Missense_Mutation_p.D605N|PPRC1_ENST00000413464.2_Missense_Mutation_p.D1374N	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	1638					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GGAAGACTTTGACCCAGCACC	0.478000													27	104					0	0	1	0	0
OTUB1	55611	broad.mit.edu	37	11	63764545	63764545	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:63764545G>A	ENST00000541478.1	+	3	604	c.144G>A	c.(142-144)gtG>gtA	p.V48V	OTUB1_ENST00000543004.1_Silent_p.V158V|OTUB1_ENST00000538426.1_Silent_p.V149V|OTUB1_ENST00000422031.2_Silent_p.V186V|OTUB1_ENST00000428192.2_Silent_p.V149V|OTUB1_ENST00000543988.1_Silent_p.V119V|OTUB1_ENST00000535715.1_Silent_p.V149V			Q96FW1	OTUB1_HUMAN	OTU domain, ubiquitin aldehyde binding 1	149					protein K48-linked deubiquitination	cytoplasm	NEDD8-specific protease activity|omega peptidase activity|ubiquitin binding|ubiquitin-specific protease activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)	6						TTGAGCAGGTGGAGAAGCAGA	0.612000													14	57					0	0	1	0	0
SETD1A	9739	broad.mit.edu	37	16	30972767	30972767	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:30972767C>T	ENST00000262519.8	+	4	1112	c.426C>T	c.(424-426)ttC>ttT	p.F142F		NM_014712.1	NP_055527.1	O15047	SET1A_HUMAN	SET domain containing 1A	142	RRM.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(21)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	59						GTGTGCTCTTCACCAGCACTC	0.572000													8	59					0	0	1	0	0
TDRD3	81550	broad.mit.edu	37	13	61041466	61041466	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr13:61041466C>G	ENST00000196169.3	+	5	957	c.169C>G	c.(169-171)Ctt>Gtt	p.L57V	TDRD3_ENST00000377894.2_Missense_Mutation_p.L57V|TDRD3_ENST00000377881.2_Missense_Mutation_p.L57V|TDRD3_ENST00000535286.1_Missense_Mutation_p.L150V	NM_001146071.1|NM_030794.2	NP_001139543.1|NP_110421.1	Q9H7E2	TDRD3_HUMAN	tudor domain containing 3	57					chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	40		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)		CACCACAGTTCTTGGTGGTGA	0.388000													36	59					0	0	1	0	0
MFRP	83552	broad.mit.edu	37	11	119216219	119216219	+	Silent	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:119216219G>C	ENST00000555262.1	-	5	711	c.552C>G	c.(550-552)ctC>ctG	p.L184L	C1QTNF5_ENST00000445041.2_5'UTR|MFRP_ENST00000529147.1_5'UTR|MFRP_ENST00000530681.1_Silent_p.L184L|MFRP_ENST00000449574.2_Silent_p.L184L|MFRP_ENST00000360167.4_Silent_p.L184L	NM_001278431.1	NP_001265360.1			membrane frizzled-related protein											autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)|urinary_tract(1)	18		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		CTTCGATCTTGAGCTGTATTG	0.577000													13	17					0	0	1	0	0
FAM179B	23116	broad.mit.edu	37	14	45478265	45478265	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr14:45478265C>G	ENST00000361462.2	+	6	3237	c.3054C>G	c.(3052-3054)atC>atG	p.I1018M	KLHL28_ENST00000553817.1_Intron|FAM179B_ENST00000361577.3_Missense_Mutation_p.I1018M|FAM179B_ENST00000382233.2_Intron			Q9Y4F4	F179B_HUMAN	family with sequence similarity 179, member B	1018	Ser-rich.						binding			endometrium(4)|kidney(5)|large_intestine(12)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	45						CACCAAACATCAATTCTTACA	0.423000													32	18					0	0	1	0	0
GEMIN2	8487	broad.mit.edu	37	14	39583536	39583536	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr14:39583536G>A	ENST00000308317.6	+	1	110	c.27G>A	c.(25-27)ttG>ttA	p.L9L	GEMIN2_ENST00000396249.2_Silent_p.L9L|GEMIN2_ENST00000250379.8_Silent_p.L9L	NM_003616.2	NP_003607.1	O14893	GEMI2_HUMAN	gem (nuclear organelle) associated protein 2	9					ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly	Cajal body|cytosol|spliceosomal complex	protein binding										TGGCTGGTTTGAAAACCATGG	0.577000													12	9					0	0	1	0	0
ITGAL	3683	broad.mit.edu	37	16	30495278	30495278	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:30495278G>A	ENST00000356798.6	+	8	1033	c.853G>A	c.(853-855)Ggg>Agg	p.G285R	ITGAL_ENST00000433423.2_Intron|ITGAL_ENST00000358164.5_Missense_Mutation_p.G202R|ITGAL_ENST00000454514.2_3'UTR|RP11-297C4.2_ENST00000569459.1_RNA	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	285	VWFA.				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	CTACATCATCGGGGTAGGGCC	0.547000													23	106					0	0	1	0	0
ZC3H6	376940	broad.mit.edu	37	2	113088891	113088891	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:113088891C>T	ENST00000409871.1	+	12	2797	c.2396C>T	c.(2395-2397)tCt>tTt	p.S799F	ZC3H6_ENST00000343936.4_Missense_Mutation_p.S799F	NM_198581.2	NP_940983.2	P61129	ZC3H6_HUMAN	zinc finger CCCH-type containing 6	799							nucleic acid binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(4)|prostate(2)	35						ATAGGCTCTTCTGTTGGTGGA	0.448000													28	32					0	0	1	0	0
PHF12	57649	broad.mit.edu	37	17	27244465	27244465	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:27244465C>T	ENST00000577226.1	-	7	1318	c.972G>A	c.(970-972)ctG>ctA	p.L324L	PHF12_ENST00000582655.1_5'UTR|PHF12_ENST00000332830.4_Silent_p.L324L|PHF12_ENST00000268756.3_Silent_p.L324L			Q96QT6	PHF12_HUMAN	PHD finger protein 12	324	Interaction with SIN3A.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			TCTTCTGGTTCAGCTAGGGAC	0.493000													16	27					0	0	1	0	0
SMG8	55181	broad.mit.edu	37	17	57290598	57290598	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:57290598G>C	ENST00000543872.2	+	4	2678	c.2414G>C	c.(2413-2415)aGa>aCa	p.R805T	SMG8_ENST00000300917.5_Missense_Mutation_p.R805T|CTD-2510F5.6_ENST00000577660.1_Intron			Q8ND04	SMG8_HUMAN	SMG8 nonsense mediated mRNA decay factor	805					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding			NS(1)|breast(5)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	33						ATCAGGACTAGAGCTGAAGAT	0.443000													24	173					0	0	1	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52002970	52002970	+	Splice_Site	SNP	G	G	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:52002970G>T	ENST00000291707.3	-	3	864	c.809C>A	c.(808-810)gCc>gAc	p.A270D	SIGLEC12_ENST00000598614.1_Splice_Site_p.A152D	NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	270					cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		GTGAGTCAGGGCTGGTGATGA	0.612000													16	26					9.16793e-09	9.65183e-09	1	1	0
ATP8B4	79895	broad.mit.edu	37	15	50226248	50226248	+	Silent	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:50226248G>C	ENST00000284509.6	-	15	1560	c.1419C>G	c.(1417-1419)ctC>ctG	p.L473L	ATP8B4_ENST00000559829.1_Silent_p.L473L	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	473					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		CAGTGTGGCAGAGAGCAAGTA	0.383000													34	59					0	0	1	0	0
CYP11B1	1584	broad.mit.edu	37	8	143957264	143957264	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:143957264C>G	ENST00000292427.4	-	6	1017	c.985G>C	c.(985-987)Gag>Cag	p.E329Q	CYP11B1_ENST00000517471.1_Missense_Mutation_p.E329Q|CYP11B1_ENST00000377675.3_Missense_Mutation_p.E400Q	NM_000497.3	NP_000488.3	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 1	329					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(36)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	67	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	CGAGCCAGCTCAAAGAGCGTC	0.647000									Familial Hyperaldosteronism type I				31	64					0	0	1	0	0
GLB1L3	112937	broad.mit.edu	37	11	134179519	134179519	+	Splice_Site	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:134179519G>A	ENST00000431683.2	+	11	961		c.e11-1			NM_001080407.2	NP_001073876.2	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3						carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		CCCCTTTGCAGAGGTTGAACA	0.428000													4	10					0	0	1	0	0
TTLL1	25809	broad.mit.edu	37	22	43447809	43447809	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr22:43447809C>G	ENST00000266254.7	-	9	1216	c.976G>C	c.(976-978)Gag>Cag	p.E326Q	TTLL1_ENST00000331018.7_Intron|AL022476.2_ENST00000443063.1_RNA	NM_012263.4	NP_036395.1	O95922	TTLL1_HUMAN	tubulin tyrosine ligase-like family, member 1	326	TTL.				protein polyglutamylation	cytoplasm|microtubule	ATP binding|tubulin-glutamic acid ligase activity|tubulin-tyrosine ligase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|skin(2)|stomach(1)	23		Ovarian(80;0.0694)		BRCA - Breast invasive adenocarcinoma(115;0.00461)		GCAGTTACCTCGATCAGCCAG	0.572000													10	38					0	0	1	0	0
ZNF292	23036	broad.mit.edu	37	6	87969009	87969009	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:87969009G>C	ENST00000369577.3	+	8	5705	c.5662G>C	c.(5662-5664)Gaa>Caa	p.E1888Q	ZNF292_ENST00000339907.4_Missense_Mutation_p.E1883Q	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	1888					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		GCCAGTTTCTGAAATGATAAA	0.373000													23	19					0	0	1	0	0
NDUFB2	4708	broad.mit.edu	37	7	140404733	140404733	+	Nonstop_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:140404733G>C	ENST00000476279.1	+	3	391	c.317G>C	c.(316-318)tGa>tCa	p.*106S	NDUFB2_ENST00000476470.1_Nonstop_Mutation_p.*42S|NDUFB2_ENST00000460088.1_Nonstop_Mutation_p.*42S|NDUFB2_ENST00000204307.5_Nonstop_Mutation_p.*96S|NDUFB2_ENST00000471136.1_Nonstop_Mutation_p.*94S|NDUFB2_ENST00000475276.1_Nonstop_Mutation_p.*79S|NDUFB2_ENST00000461457.1_Intron|NDUFB2_ENST00000482954.1_Nonstop_Mutation_p.*42S|NDUFB2_ENST00000465506.1_Nonstop_Mutation_p.*106S|NDUFB2_ENST00000464564.2_3'UTR|NDUFB2_ENST00000472695.1_Nonstop_Mutation_p.*42S|NDUFB2_ENST00000247866.4_Nonstop_Mutation_p.*106S			O95178	NDUB2_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa	0					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|stomach(1)	10	Melanoma(164;0.00956)				NADH(DB00157)	GATGAAGACTGAAGGTGTAGA	0.398000													18	43					0	0	1	0	0
GRK6	2870	broad.mit.edu	37	5	176863145	176863145	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:176863145G>A	ENST00000355472.5	+	12	1297	c.1129G>A	c.(1129-1131)Gag>Aag	p.E377K	GRK6_ENST00000507633.1_Missense_Mutation_p.E377K|GRK6_ENST00000528793.1_Missense_Mutation_p.E377K|GRK6_ENST00000393576.3_Missense_Mutation_p.E343K|GRK6_ENST00000355958.5_Missense_Mutation_p.E377K	NM_001004106.2|NM_002082.3	NP_001004106.1|NP_002073.2	P43250	GRK6_HUMAN	G protein-coupled receptor kinase 6	377	Protein kinase.				regulation of G-protein coupled receptor protein signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(5)|stomach(1)	25	all_cancers(89;1.15e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCTCCTGTACGAGATGATCGC	0.627000													8	18					0	0	1	0	0
CD2BP2	10421	broad.mit.edu	37	16	30364574	30364574	+	Silent	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:30364574C>G	ENST00000305596.3	-	6	1018	c.843G>C	c.(841-843)gtG>gtC	p.V281V	CD2BP2_ENST00000569466.1_Silent_p.V281V	NM_006110.2	NP_006101.1	O95400	CD2B2_HUMAN	CD2 (cytoplasmic tail) binding protein 2	281	GYF.				assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			breast(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)	15						ATTCCCACATCACATCCACCA	0.572000													20	30					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802704	185802704	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:185802704G>A	ENST00000302277.6	+	4	3175	c.2581G>A	c.(2581-2583)Gaa>Aaa	p.E861K		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	861						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						GAAACCACAAGAAGTTGCAAA	0.348000													18	16					0	0	1	0	0
MYBPC3	4607	broad.mit.edu	37	11	47363624	47363624	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:47363624C>T	ENST00000399249.2	-	17	1762	c.1708G>A	c.(1708-1710)Gat>Aat	p.D570N	MYBPC3_ENST00000256993.4_Missense_Mutation_p.D569N|MYBPC3_ENST00000545968.1_Missense_Mutation_p.D570N			Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	569	Ig-like C2-type 4.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(3)|urinary_tract(2)	42				Lung(87;0.176)		ACATTCTCATCTGAGACCTCA	0.587000													4	26					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23757123	23757123	+	Missense_Mutation	SNP	C	C	G	rs142516836		TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:23757123C>G	ENST00000354639.3	+	4	569	c.105C>G	c.(103-105)atC>atG	p.I35M	STK31_ENST00000433467.2_Missense_Mutation_p.I58M|STK31_ENST00000355870.3_Missense_Mutation_p.I58M|STK31_ENST00000428484.1_Missense_Mutation_p.I35M	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	58							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						ATAAGGATATCATGAAGATTG	0.358000													16	19					0	0	1	0	0
STAT4	6775	broad.mit.edu	37	2	191934458	191934458	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:191934458C>G	ENST00000392320.2	-	6	819	c.505G>C	c.(505-507)Gac>Cac	p.D169H	STAT4_ENST00000358470.4_Missense_Mutation_p.D169H	NM_003151.3	NP_003142.1	Q14765	STAT4_HUMAN	signal transducer and activator of transcription 4	169					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(4)|endometrium(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			TCAAATTCGTCTTGCAGATCT	0.323000													31	44					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34080600	34080600	+	Silent	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:34080600C>A	ENST00000389232.4	+	67	9841	c.9771C>A	c.(9769-9771)gtC>gtA	p.V3257V	RYR3_ENST00000415757.3_Silent_p.V3257V	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3257					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AGTTCGCGGTCCTCTGCAGAG	0.577000													8	41					0.00448238	0.0045253	1	1	0
TMEM260	54916	broad.mit.edu	37	14	57103286	57103286	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr14:57103286G>A	ENST00000261556.6	+	15	1961	c.1839G>A	c.(1837-1839)gtG>gtA	p.V613V	RP11-1085N6.2_ENST00000555924.1_RNA|RP11-1085N6.2_ENST00000553800.1_RNA|TMEM260_ENST00000536419.1_Silent_p.V147V	NM_017799.3	NP_060269.3			transmembrane protein 260																		CTTCAAAAGTGAAAGCTCAAC	0.398000													20	13					0	0	1	0	0
MRPL20	55052	broad.mit.edu	37	1	1342310	1342310	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:1342310C>T	ENST00000482352.1	-	2	249	c.177G>A	c.(175-177)ctG>ctA	p.L59L	MRPL20_ENST00000344843.7_Silent_p.L59L			Q9BYC9	RM20_HUMAN	mitochondrial ribosomal protein L20	59							protein binding|rRNA binding			endometrium(1)|large_intestine(1)|lung(2)|prostate(1)	5	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		TCTTTTTCTTCAGGTATCGGG	0.597000													73	124					0	0	1	0	0
FAM175B	23172	broad.mit.edu	37	10	126490428	126490428	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:126490428C>T	ENST00000298492.5	+	1	75	c.30C>T	c.(28-30)ttC>ttT	p.F10F		NM_032182.3	NP_115558.3	Q15018	F175B_HUMAN	family with sequence similarity 175, member B	10	MPN-like.					BRISC complex	polyubiquitin binding			NS(1)	1						GCTACACCTTCAGTGCTGTGT	0.672000													19	98					0	0	1	0	0
MMS19	64210	broad.mit.edu	37	10	99218606	99218606	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:99218606C>T	ENST00000438925.2	-	30	3351	c.3016G>A	c.(3016-3018)Gac>Aac	p.D1006N	MMS19_ENST00000327277.7_3'UTR|MMS19_ENST00000370782.2_Missense_Mutation_p.D1006N|MMS19_ENST00000327238.10_Missense_Mutation_p.D908N|MMS19_ENST00000355839.6_Missense_Mutation_p.D963N	NM_022362.4	NP_071757.4	Q96T76	MMS19_HUMAN	MMS19 nucleotide excision repair homolog (S. cerevisiae)	1006					chromosome segregation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|response to hormone stimulus|transcription, DNA-dependent|two-component signal transduction system (phosphorelay)	cytoplasm|holo TFIIH complex|MMXD complex	estrogen receptor binding|protein binding, bridging|receptor signaling complex scaffold activity|transcription coactivator activity			endometrium(1)|kidney(2)|large_intestine(5)|lung(6)|prostate(1)|stomach(1)	16		Colorectal(252;0.0846)		Epithelial(162;3.33e-10)|all cancers(201;2.74e-08)		CTCTTCTTGTCATCCAGGGGT	0.532000								Direct reversal of damage					12	12					0	0	1	0	0
SBF1	6305	broad.mit.edu	37	22	50892960	50892960	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr22:50892960G>C	ENST00000380817.3	-	36	5207	c.5024C>G	c.(5023-5025)gCc>gGc	p.A1675G	SBF1_ENST00000348911.6_Missense_Mutation_p.A1650G|SBF1_ENST00000390679.3_Missense_Mutation_p.A1649G	NM_002972.2	NP_002963.2	O95248	MTMR5_HUMAN	SET binding factor 1						protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(8)|large_intestine(3)|lung(18)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	43		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		GCGTGAGATGGCGTCAGGCTG	0.677000													15	23					0	0	1	0	0
TDRD9	122402	broad.mit.edu	37	14	104472828	104472828	+	Nonsense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr14:104472828C>T	ENST00000409874.4	+	16	1864	c.1816C>T	c.(1816-1818)Caa>Taa	p.Q606*	TDRD9_ENST00000339063.5_Nonsense_Mutation_p.Q606*	NM_153046.2	NP_694591.2	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	606					cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				TGTAAATCAGCAACTTGGTAA	0.398000													25	13					0	0	1	0	0
MCM3AP	8888	broad.mit.edu	37	21	47695150	47695150	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr21:47695150C>T	ENST00000397708.1	-	7	2202	c.1948G>A	c.(1948-1950)Gag>Aag	p.E650K	MCM3AP_ENST00000291688.1_Missense_Mutation_p.E650K			O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3 associated protein	650					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(5)|large_intestine(17)|lung(24)|ovary(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	72	Breast(49;0.112)					CTACGGGTCTCCCGCATGTAC	0.587000													3	22					0	0	1	0	0
TK1	7083	broad.mit.edu	37	17	76171688	76171688	+	Missense_Mutation	SNP	G	G	C	rs143988750		TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:76171688G>C	ENST00000588734.1	-	5	553	c.315C>G	c.(313-315)atC>atG	p.I105M	TK1_ENST00000590862.1_Missense_Mutation_p.I105M|TK1_ENST00000405273.1_Missense_Mutation_p.I105M|TK1_ENST00000590430.1_Missense_Mutation_p.S74W|TK1_ENST00000301634.7_Missense_Mutation_p.I105M			P04183	KITH_HUMAN	thymidine kinase 1, soluble	105					DNA replication|protein homotetramerization|pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|thymidine kinase activity|zinc ion binding			endometrium(1)|large_intestine(1)|urinary_tract(2)	4			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.0804)|Lung(188;0.23)			AGAACTCCACGATGTCAGGGA	0.597000													25	39					0	0	1	0	0
HRASLS5	117245	broad.mit.edu	37	11	63257771	63257771	+	Silent	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:63257771G>C	ENST00000540857.1	-	2	315	c.183C>G	c.(181-183)ctC>ctG	p.L61L	HRASLS5_ENST00000539221.1_Silent_p.L71L|HRASLS5_ENST00000301790.4_Silent_p.L71L	NM_001146728.1|NM_001146729.1|NM_054108.3	NP_001140200.1|NP_001140201|NP_473449.1	Q96KN8	HRSL5_HUMAN	HRAS-like suppressor family, member 5	71										endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|urinary_tract(1)	14						GCTTGGCTGGGAGCTGGACCA	0.522000													52	169					0	0	1	0	0
WNK4	65266	broad.mit.edu	37	17	40948536	40948536	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:40948536C>T	ENST00000246914.5	+	18	3690	c.3669C>T	c.(3667-3669)acC>acT	p.T1223T		NM_032387.4	NP_115763.2	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	0					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|prostate(1)|skin(5)|stomach(1)	35		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		GCAGCAGCACCGGCTCCCAGG	0.647000													9	33					0	0	1	0	0
CRLF1	9244	broad.mit.edu	37	19	18707818	18707818	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:18707818C>T	ENST00000392386.3	-	5	932	c.739G>A	c.(739-741)Ggg>Agg	p.G247R		NM_004750.4	NP_004741.1	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1	247	Fibronectin type-III 2.				negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)	9						TCCAGGCCCCCGACGCGGCTC	0.662000													6	18					0	0	1	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102304772	102304772	+	RNA	SNP	T	T	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:102304772T>C	ENST00000561463.1	+	0	12818																											CACAGCGGCGTGACGAGACTC	0.587000													3	12					0	0	1	0	0
NPHS1	4868	broad.mit.edu	37	19	36322260	36322260	+	Silent	SNP	G	G	T	rs137853042		TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:36322260G>T	ENST00000378910.5	-	26	3324	c.3325C>A	c.(3325-3327)Cga>Aga	p.R1109R	NPHS1_ENST00000353632.6_Silent_p.R1069R	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	1109					cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TTCCTGACTCGGTCCTCTTCC	0.607000													13	95					1.5842e-08	1.66544e-08	1	1	0
SPEF2	79925	broad.mit.edu	37	5	35759808	35759808	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:35759808G>A	ENST00000440995.2	+	25	3592	c.3592G>A	c.(3592-3594)Gaa>Aaa	p.E1198K	CTD-2113L7.1_ENST00000510433.1_RNA|SPEF2_ENST00000356031.3_Missense_Mutation_p.E1203K			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1203					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGACAATTCTGAAAGCCAGCT	0.343000													18	47					0	0	1	0	0
TIGD7	91151	broad.mit.edu	37	16	3349798	3349798	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:3349798C>G	ENST00000396862.1	-	2	2645	c.817G>C	c.(817-819)Gag>Cag	p.E273Q	TIGD7_ENST00000268674.2_Missense_Mutation_p.E273Q	NM_033208.3	NP_149985.2	Q6NT04	TIGD7_HUMAN	tigger transposable element derived 7	273	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding	p.E273K(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	12						TGTCGGACCTCaggaacaaag	0.408000													38	32					0	0	1	0	0
RNF123	63891	broad.mit.edu	37	3	49758502	49758502	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:49758502C>G	ENST00000327697.6	+	38	3932	c.3788C>G	c.(3787-3789)tCt>tGt	p.S1263C	GMPPB_ENST00000480687.1_3'UTR|RNF123_ENST00000433785.1_Missense_Mutation_p.S375C|AMIGO3_ENST00000535833.1_5'UTR|GMPPB_ENST00000308375.6_3'UTR	NM_022064.3	NP_071347.2	Q5XPI4	RN123_HUMAN	ring finger protein 123	1263						cytoplasm	ligase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		CACCCCATCTCTGCTGTGTTC	0.612000													19	43					0	0	1	0	0
SEC61A2	55176	broad.mit.edu	37	10	12199989	12199989	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:12199989C>T	ENST00000379033.3	+	8	941	c.794C>T	c.(793-795)tCc>tTc	p.S265F	SEC61A2_ENST00000298428.9_Missense_Mutation_p.S287F|SEC61A2_ENST00000379020.4_Intron|SEC61A2_ENST00000304267.8_Missense_Mutation_p.S287F|SEC61A2_ENST00000495368.1_3'UTR	NM_001142628.1	NP_001136100.1	Q9H9S3	S61A2_HUMAN	Sec61 alpha 2 subunit (S. cerevisiae)	287						endoplasmic reticulum membrane|integral to membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		Renal(717;0.228)				TTCTACACCTCCAACATCCCC	0.473000													67	39					0	0	1	0	0
DLL4	54567	broad.mit.edu	37	15	41228930	41228930	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:41228930C>A	ENST00000249749.5	+	9	2021	c.1745C>A	c.(1744-1746)gCc>gAc	p.A582D		NM_019074.3	NP_061947.1	Q9NR61	DLL4_HUMAN	delta-like 4 (Drosophila)	582					blood circulation|cell communication|cell differentiation|Notch receptor processing|Notch signaling pathway	integral to membrane|plasma membrane	calcium ion binding|Notch binding			breast(3)|large_intestine(1)	4		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		CTGATTCCTGCCGCCCAGCTT	0.557000													9	32					0.00448238	0.0045253	1	1	0
OSBPL3	26031	broad.mit.edu	37	7	24932045	24932045	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:24932045G>A	ENST00000313367.2	-	2	498	c.47C>T	c.(46-48)tCa>tTa	p.S16L	OSBPL3_ENST00000396429.1_Missense_Mutation_p.S16L|OSBPL3_ENST00000352860.1_Missense_Mutation_p.S16L|OSBPL3_ENST00000431825.2_Missense_Mutation_p.S16L|OSBPL3_ENST00000353930.1_Missense_Mutation_p.S16L|OSBPL3_ENST00000396431.1_Missense_Mutation_p.S16L|OSBPL3_ENST00000409069.1_Missense_Mutation_p.S16L	NM_015550.2	NP_056365.1	Q9H4L5	OSBL3_HUMAN	oxysterol binding protein-like 3	16					lipid transport		lipid binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(19)|prostate(1)|skin(3)|urinary_tract(1)	43						CCTTGAAGGTGATACCAATTT	0.423000													37	58					0	0	1	0	0
ALDH18A1	5832	broad.mit.edu	37	10	97402927	97402927	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:97402927G>A	ENST00000371224.2	-	3	262	c.125C>T	c.(124-126)tCt>tTt	p.S42F	ALDH18A1_ENST00000371221.3_Missense_Mutation_p.S42F|ALDH18A1_ENST00000483788.1_5'UTR	NM_002860.3	NP_002851.2	P54886	P5CS_HUMAN	aldehyde dehydrogenase 18 family, member A1	42	Glutamate 5-kinase.				proline biosynthetic process	mitochondrial inner membrane	ATP binding|glutamate 5-kinase activity|glutamate-5-semialdehyde dehydrogenase activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(9)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Colorectal(252;0.0402)		Epithelial(162;9.1e-07)|all cancers(201;2.55e-05)	L-Glutamic Acid(DB00142)	GTTGCTCCAAGAACGAACATG	0.428000													10	35					0	0	1	0	0
C1QTNF2	114898	broad.mit.edu	37	5	159797634	159797634	+	Missense_Mutation	SNP	A	A	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:159797634A>C	ENST00000393975.3	-	1	14	c.11T>G	c.(10-12)cTa>cGa	p.L4R		NM_031908.4	NP_114114.2	Q9BXJ5	C1QT2_HUMAN	C1q and tumor necrosis factor related protein 2	0						collagen				breast(2)|endometrium(2)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	13	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCCCAGGCATAGTTTTCCCAT	0.647000													7	19					0	0	1	0	0
DOK2	9046	broad.mit.edu	37	8	21767043	21767043	+	Nonsense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:21767043G>A	ENST00000276420.4	-	5	1276	c.1018C>T	c.(1018-1020)Cga>Tga	p.R340*	DOK2_ENST00000544659.1_Nonsense_Mutation_p.R186*	NM_003974.2	NP_003965.2	O60496	DOK2_HUMAN	docking protein 2, 56kDa	340	Pro-rich.				blood coagulation|leukocyte migration	cytosol	identical protein binding|insulin receptor binding			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(3)|skin(1)	26				Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		TGGTCAGGTCGAGGGGGCAGG	0.647000													18	23					0	0	1	0	0
OR10A4	283297	broad.mit.edu	37	11	6898686	6898686	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:6898686G>A	ENST00000379829.2	+	1	831	c.808G>A	c.(808-810)Gag>Aag	p.E270K		NM_207186.2	NP_997069.2	Q9H209	O10A4_HUMAN	olfactory receptor, family 10, subfamily A, member 4	270					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(2)|liver(2)|lung(20)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	31		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TGCCTCTTCTGAGAGCAAGAA	0.507000													20	48					0	0	1	0	0
CSDE1	7812	broad.mit.edu	37	1	115279464	115279464	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:115279464G>C	ENST00000438362.2	-	6	931	c.553C>G	c.(553-555)Ctg>Gtg	p.L185V	CSDE1_ENST00000358528.4_Missense_Mutation_p.L139V|CSDE1_ENST00000534699.1_Missense_Mutation_p.L139V|CSDE1_ENST00000530886.1_Missense_Mutation_p.L9V|CSDE1_ENST00000369530.1_Missense_Mutation_p.L154V|CSDE1_ENST00000261443.5_Missense_Mutation_p.L108V|CSDE1_ENST00000339438.6_Missense_Mutation_p.L108V	NM_001242891.1	NP_001229820.1	O75534	CSDE1_HUMAN	cold shock domain containing E1, RNA-binding	139					male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			NS(1)|breast(4)|endometrium(11)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	51	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTGTAAGTCAGATAAAACACT	0.308000													59	69					0	0	1	0	0
SPICE1	152185	broad.mit.edu	37	3	113169288	113169288	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:113169288C>G	ENST00000295872.4	-	15	2477	c.2218G>C	c.(2218-2220)Gag>Cag	p.E740Q		NM_144718.3	NP_653319.1	Q8N0Z3	SPICE_HUMAN	spindle and centriole associated protein 1	740					cell division|mitosis	centriole|spindle	protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(3)|large_intestine(9)|lung(10)|ovary(2)|skin(2)|urinary_tract(1)	33						CCACGAGCCTCCATACTTTGT	0.418000													22	34					0	0	1	0	0
NPR1	4881	broad.mit.edu	37	1	153655903	153655903	+	Missense_Mutation	SNP	C	C	A	rs41302111		TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:153655903C>A	ENST00000368680.3	+	6	1787	c.1315C>A	c.(1315-1317)Cgc>Agc	p.R439S		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	439					body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	TGTGTCGGGGCGCAAACTGAA	0.597000													23	34					3.28513e-13	3.50857e-13	1	1	0
DCAF15	90379	broad.mit.edu	37	19	14066959	14066959	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:14066959C>T	ENST00000254337.6	+	5	519	c.498C>T	c.(496-498)ctC>ctT	p.L166L		NM_138353.2	NP_612362.2	Q66K64	DCA15_HUMAN	DDB1 and CUL4 associated factor 15	166										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)	11						ACGGGATGCTCATGAACATGA	0.667000													7	9					0	0	1	0	0
CRLF3	51379	broad.mit.edu	37	17	29123330	29123330	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:29123330C>T	ENST00000324238.6	-	4	575	c.451G>A	c.(451-453)Gat>Aat	p.D151N	CRLF3_ENST00000544695.1_Missense_Mutation_p.D35N|CRLF3_ENST00000577725.1_Intron	NM_015986.3	NP_057070.3	Q8IUI8	CRLF3_HUMAN	cytokine receptor-like factor 3	151					negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|positive regulation of cell cycle arrest|positive regulation of JAK-STAT cascade|positive regulation of transcription from RNA polymerase II promoter	cytoplasm				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	17		all_hematologic(16;0.014)|Acute lymphoblastic leukemia(14;0.0236)|Myeloproliferative disorder(56;0.0255)				CAAGGCACATCAACCAGTAAA	0.383000													52	57					0	0	1	0	0
MAZ	4150	broad.mit.edu	37	16	29818814	29818814	+	Silent	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:29818814G>C	ENST00000219782.6	+	2	814	c.708G>C	c.(706-708)ctG>ctC	p.L236L	MAZ_ENST00000545521.1_Silent_p.L213L|AC009133.15_ENST00000566537.1_RNA|MAZ_ENST00000322945.6_Silent_p.L236L|MAZ_ENST00000566906.2_Intron|MAZ_ENST00000562337.1_Intron|MAZ_ENST00000563402.1_Intron	NM_001042539.1	NP_001036004.1	P56270	MAZ_HUMAN	MYC-associated zinc finger protein (purine-binding transcription factor)	236					regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription|transcription initiation from RNA polymerase II promoter	nucleus	DNA binding|protein binding|RNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	10						TGAGCCTCCTGAGCGTGCCCC	0.736000													5	16					0	0	1	0	0
RPS6KA2	6196	broad.mit.edu	37	6	166845945	166845945	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:166845945C>G	ENST00000510118.1	-	17	1781	c.1441G>C	c.(1441-1443)Gag>Cag	p.E481Q	RPS6KA2_ENST00000481261.2_Missense_Mutation_p.E367Q|RPS6KA2_ENST00000503859.1_Missense_Mutation_p.E464Q|RPS6KA2_ENST00000405189.3_Missense_Mutation_p.E367Q|RPS6KA2_ENST00000265678.4_Missense_Mutation_p.E456Q			Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 2	456	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		ATCTCAATCTCTTCCGAGGGG	0.532000													3	12					0	0	1	0	0
MGA	23269	broad.mit.edu	37	15	42041716	42041716	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:42041716G>A	ENST00000219905.7	+	17	6092	c.5911G>A	c.(5911-5913)Gaa>Aaa	p.E1971K	MGA_ENST00000545763.1_Missense_Mutation_p.E1762K|MGA_ENST00000570161.1_Missense_Mutation_p.E1971K|MGA_ENST00000389936.4_Missense_Mutation_p.E1932K|MGA_ENST00000566586.1_Missense_Mutation_p.E1762K	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	1932						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		GATGAAGAGAGAATCTCAGAA	0.448000													11	19					0	0	1	0	0
DHRS4L1	728635	broad.mit.edu	37	14	24517432	24517432	+	RNA	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr14:24517432G>C	ENST00000558293.1	+	0	505					NR_102693.1																						ATGGAGAAACGAGGGTACAGA	0.517000													21	12					0	0	1	0	0
HACL1	26061	broad.mit.edu	37	3	15613207	15613207	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:15613207C>G	ENST00000321169.5	-	12	1430	c.1063G>C	c.(1063-1065)Gaa>Caa	p.E355Q	HACL1_ENST00000456194.2_Missense_Mutation_p.E328Q|HACL1_ENST00000435217.2_Missense_Mutation_p.E114Q|HACL1_ENST00000457447.2_Intron|HACL1_ENST00000451445.2_Missense_Mutation_p.E273Q	NM_012260.2	NP_036392.2	Q9UJ83	HACL1_HUMAN	2-hydroxyacyl-CoA lyase 1	355					fatty acid alpha-oxidation	peroxisomal matrix	carbon-carbon lyase activity|identical protein binding|magnesium ion binding|thiamine pyrophosphate binding			NS(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|skin(1)	16						TTCATTTTTTCTCTCAGAGTT	0.403000													80	86					0	0	1	0	0
VIT	5212	broad.mit.edu	37	2	36994366	36994366	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:36994366C>T	ENST00000379242.3	+	7	919	c.617C>T	c.(616-618)tCt>tTt	p.S206F	VIT_ENST00000379241.3_Missense_Mutation_p.S206F|VIT_ENST00000401530.1_Missense_Mutation_p.S206F|VIT_ENST00000404084.1_Missense_Mutation_p.S184F|VIT_ENST00000389975.3_Missense_Mutation_p.S206F|VIT_ENST00000497382.1_5'UTR	NM_053276.3	NP_444506.2	Q6UXI7	VITRN_HUMAN	vitrin	206						proteinaceous extracellular matrix				autonomic_ganglia(1)|breast(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_hematologic(82;0.248)				CCATCCCCTTCTGCTGCTTCT	0.577000													9	11					0	0	1	0	0
FTHL17	53940	broad.mit.edu	37	X	31089858	31089858	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chrX:31089858C>T	ENST00000359202.3	-	1	312	c.213G>A	c.(211-213)atG>atA	p.M71I		NM_031894.2	NP_114100.1	Q9BXU8	FHL17_HUMAN	ferritin, heavy polypeptide-like 17	71	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport		ferric iron binding|oxidoreductase activity			endometrium(2)|large_intestine(2)|liver(1)|lung(13)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	23						TCTGCAGCCTCATCAGCTTCT	0.607000													16	6					0	0	1	0	0
GCC2	9648	broad.mit.edu	37	2	109109090	109109090	+	Nonsense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:109109090C>T	ENST00000309863.6	+	19	5005	c.4291C>T	c.(4291-4293)Cag>Tag	p.Q1431*		NM_181453.3	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain containing 2	1431					Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			breast(8)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	54						GACTGTGAGTCAGCTAACATC	0.413000													4	26					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38154096	38154096	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr22:38154096G>A	ENST00000406386.3	+	16	6419	c.6164G>A	c.(6163-6165)gGa>gAa	p.G2055E	TRIOBP_ENST00000407319.2_Missense_Mutation_p.G342E|TRIOBP_ENST00000403663.2_Missense_Mutation_p.G342E	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	2055					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					CAAAGCCGCGGAGAGCGCCGA	0.662000													3	9					0	0	1	0	0
SHF	90525	broad.mit.edu	37	15	45491080	45491080	+	Missense_Mutation	SNP	A	A	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:45491080A>G	ENST00000290894.8	-	2	687	c.193T>C	c.(193-195)Tca>Cca	p.S65P	CTD-2651B20.7_ENST00000568314.1_RNA|SHF_ENST00000318390.6_Missense_Mutation_p.S122P|RP11-519G16.2_ENST00000560034.1_RNA	NM_138356.2	NP_612365	B3KTY1	B3KTY1_HUMAN	Src homology 2 domain containing F	65										endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(2)	12		all_cancers(109;8.13e-11)|all_epithelial(112;6.29e-09)|Lung NSC(122;3.57e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.1e-16)|GBM - Glioblastoma multiforme(94;5.98e-06)		TGTGGTGATGATGAGATGGGC	0.592000											OREG0023105	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	79					0	0	1	0	0
ZNF622	90441	broad.mit.edu	37	5	16465581	16465581	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:16465581G>C	ENST00000308683.2	-	1	320	c.194C>G	c.(193-195)tCg>tGg	p.S65W		NM_033414.2	NP_219482.1	Q969S3	ZN622_HUMAN	zinc finger protein 622	65						cytoplasm|nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						GTAGGTGGCCGAGCCCTTGCT	0.652000													23	31					0	0	1	0	0
DALRD3	55152	broad.mit.edu	37	3	49053871	49053871	+	Silent	SNP	T	T	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:49053871T>G	ENST00000440857.1	-	9	1338	c.636A>C	c.(634-636)ccA>ccC	p.P212P	DALRD3_ENST00000441576.2_Silent_p.P379P|DALRD3_ENST00000395462.4_Silent_p.P212P|DALRD3_ENST00000313778.5_Silent_p.P212P|DALRD3_ENST00000341949.4_Silent_p.P379P			Q5D0E6	DALD3_HUMAN	DALR anticodon binding domain containing 3	379					arginyl-tRNA aminoacylation	cytoplasm	arginine-tRNA ligase activity|ATP binding			breast(2)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	12				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CCTGACTCTGTGGGGCTGTGC	0.577000													9	32					0	0	1	0	0
KCNRG	283518	broad.mit.edu	37	13	50589920	50589920	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr13:50589920C>T	ENST00000360473.4	+	1	531	c.291C>T	c.(289-291)ctC>ctT	p.L97L	TRIM13_ENST00000478111.1_Intron|KCNRG_ENST00000312942.1_Silent_p.L97L|TRIM13_ENST00000378182.3_3'UTR	NM_199464.2	NP_955751.1	Q8N5I3	KCNRG_HUMAN	potassium channel regulator	97	BTB.					voltage-gated potassium channel complex	identical protein binding|voltage-gated potassium channel activity			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)	9		Acute lymphoblastic leukemia(7;3.41e-06)|Lung NSC(96;3.08e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.48e-10)|COAD - Colon adenocarcinoma(199;0.204)		TAGTTGATCTCTTAAACCCAT	0.433000													24	72					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29483132	29483132	+	Silent	SNP	T	T	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:29483132T>C	ENST00000358273.4	+	2	575	c.192T>C	c.(190-192)aaT>aaC	p.N64N	NF1_ENST00000356175.3_Silent_p.N64N|NF1_ENST00000431387.4_Silent_p.N64N	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	64					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(3)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TTTTAAAGAATGTTAACAATA	0.313000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			19	148					0	0	1	0	0
RAB4B-EGLN2	100529264	broad.mit.edu	37	19	41292604	41292604	+	Silent	SNP	C	C	T	rs150920149		TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:41292604C>T	ENST00000594136.1	+	6	570	c.465C>T	c.(463-465)ggC>ggT	p.G155G	RAB4B_ENST00000594800.1_Silent_p.G155G|RAB4B-EGLN2_ENST00000601949.1_3'UTR|RAB4B_ENST00000602069.1_3'UTR|RAB4B_ENST00000357052.2_Silent_p.G155G																							CTCTCACAGGCGAGAACGTGG	0.627000													4	21					0	0	1	0	0
NUP43	348995	broad.mit.edu	37	6	150067551	150067551	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:150067551C>G	ENST00000340413.2	-	1	157	c.81G>C	c.(79-81)caG>caC	p.Q27H	NUP43_ENST00000463048.3_Intron|NUP43_ENST00000460354.2_Missense_Mutation_p.Q27H|NUP43_ENST00000367403.3_Missense_Mutation_p.Q88H|NUP43_ENST00000367404.4_Missense_Mutation_p.Q27H	NM_198887.1	NP_942590.1	Q8NFH3	NUP43_HUMAN	nucleoporin 43kDa	27					carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			breast(1)|large_intestine(2)|lung(8)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	18		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;4.71e-13)|GBM - Glioblastoma multiforme(68;0.101)		TCTCCGCGGTCTGTAAACTTC	0.582000											OREG0017720	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	83					0	0	1	0	0
BIN3	55909	broad.mit.edu	37	8	22481852	22481852	+	Silent	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:22481852G>C	ENST00000276416.6	-	7	431	c.363C>G	c.(361-363)ctC>ctG	p.L121L	BIN3_ENST00000519335.1_5'UTR|BIN3_ENST00000519513.1_Silent_p.L67L|BIN3_ENST00000399977.4_Silent_p.L73L	NM_018688.4	NP_061158.1	Q9NQY0	BIN3_HUMAN	bridging integrator 3	121	BAR.				actin filament organization|barrier septum formation|cell cycle|protein localization|unidimensional cell growth	cytoplasm|cytoskeleton	cytoskeletal adaptor activity			kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	9		Prostate(55;0.0424)|Breast(100;0.102)|all_epithelial(46;0.143)		BRCA - Breast invasive adenocarcinoma(99;0.00664)|Colorectal(74;0.0189)|COAD - Colon adenocarcinoma(73;0.0727)		CAGCCATGTTGAGGCTCGGGA	0.607000													8	28					0	0	1	0	0
CARM1	10498	broad.mit.edu	37	19	11019874	11019874	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:11019874C>G	ENST00000327064.4	+	4	739	c.549C>G	c.(547-549)ttC>ttG	p.F183L	CARM1_ENST00000344150.4_Missense_Mutation_p.F183L	NM_199141.1	NP_954592.1	Q86X55	CARM1_HUMAN	coactivator-associated arginine methyltransferase 1	183					cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	13						ACACCGACTTCAAGGACAAGG	0.493000													20	20					0	0	1	0	0
COQ10B	80219	broad.mit.edu	37	2	198324752	198324752	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:198324752C>T	ENST00000263960.2	+	2	339	c.201C>T	c.(199-201)atC>atT	p.I67I	COQ10B_ENST00000409010.1_Silent_p.I39I|COQ10B_ENST00000545340.1_Silent_p.I24I|COQ10B_ENST00000409398.1_Intron	NM_025147.3	NP_079423.1	Q9H8M1	CQ10B_HUMAN	coenzyme Q10 homolog B (S. cerevisiae)	67						mitochondrial inner membrane				endometrium(1)|large_intestine(2)|lung(3)	6			Epithelial(96;0.231)|OV - Ovarian serous cystadenocarcinoma(117;0.246)			TCTTCAAAATCACTGCACCAT	0.338000													18	10					0	0	1	0	0
LRRC10	376132	broad.mit.edu	37	12	70003977	70003977	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:70003977C>T	ENST00000361484.3	-	1	965	c.642G>A	c.(640-642)ctG>ctA	p.L214L		NM_201550.2	NP_963844.2	Q5BKY1	LRC10_HUMAN	leucine rich repeat containing 10	214						nucleus				large_intestine(2)|lung(6)	8	all_cancers(2;2.83e-105)|Breast(13;9.83e-07)|Esophageal squamous(21;0.187)		Epithelial(6;1.98e-18)|GBM - Glioblastoma multiforme(2;7.43e-12)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			TGACCAGCTTCAGACTTGACA	0.582000													10	22					0	0	1	0	0
CHCHD7	79145	broad.mit.edu	37	8	57129959	57129959	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:57129959G>C	ENST00000523975.1	+	5	407	c.259G>C	c.(259-261)Gaa>Caa	p.E87Q	CHCHD7_ENST00000303759.3_Missense_Mutation_p.E100Q|CHCHD7_ENST00000521831.1_3'UTR|CHCHD7_ENST00000518801.1_3'UTR|CHCHD7_ENST00000396723.5_Missense_Mutation_p.E84Q|CHCHD7_ENST00000519367.1_3'UTR|CHCHD7_ENST00000523061.1_3'UTR|CHCHD7_ENST00000521524.1_3'UTR|CHCHD7_ENST00000355315.3_Missense_Mutation_p.E75Q			Q9BUK0	CHCH7_HUMAN	coiled-coil-helix-coiled-coil-helix domain containing 7	75									CHCHD7/PLAG1(12)	endometrium(1)	1		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00159)|all cancers(17;0.0112)			AGAAAGAGATGAAATCTTGAG	0.348000			T	PLAG1	salivary adenoma								11	44					0	0	1	0	0
TSR2	90121	broad.mit.edu	37	X	54470515	54470515	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chrX:54470515C>T	ENST00000375151.4	+	4	360	c.339C>T	c.(337-339)tcC>tcT	p.S113S		NM_058163.1	NP_477511.1	Q969E8	TSR2_HUMAN	TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)	113					rRNA processing		protein binding			breast(1)|endometrium(3)|lung(2)	6						AGATGGCCTCCTGCATCACTC	0.502000													16	11					0	0	1	0	0
STAG3L4	64940	broad.mit.edu	37	7	66770992	66770992	+	RNA	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:66770992C>T	ENST00000416602.2	+	0	284					NR_040586.1		Q8TBR4	STG34_HUMAN												endometrium(2)|lung(5)	7		Lung NSC(55;0.0839)|all_lung(88;0.181)				AGATGAGTGGCTGGATAGCTA	0.398000													28	137					0	0	1	0	0
FAM151B	167555	broad.mit.edu	37	5	79817869	79817869	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:79817869C>A	ENST00000282226.4	+	5	738	c.583C>A	c.(583-585)Cta>Ata	p.L195I	FAM151B_ENST00000511718.1_3'UTR	NM_205548.2	NP_991111.2	Q6UXP7	F151B_HUMAN	family with sequence similarity 151, member B	195										breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)	7		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;8.21e-47)|Epithelial(54;8.3e-42)|all cancers(79;1.97e-36)		ATGTAATGAACTAAGTCAGCC	0.338000													12	55					7.03913e-09	7.43187e-09	1	1	0
FBXO30	84085	broad.mit.edu	37	6	146126928	146126928	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:146126928C>G	ENST00000237281.4	-	2	780	c.614G>C	c.(613-615)aGa>aCa	p.R205T		NM_032145.4	NP_115521.3	Q8TB52	FBX30_HUMAN	F-box protein 30	205							ubiquitin-protein ligase activity|zinc ion binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26		Ovarian(120;0.0776)		OV - Ovarian serous cystadenocarcinoma(155;1.95e-07)|GBM - Glioblastoma multiforme(68;0.0149)		GCCAATGTCTCTTGTAGCAGT	0.393000													22	142					0	0	1	0	0
PLA2G4B	100137049	broad.mit.edu	37	15	42138406	42138406	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:42138406G>C	ENST00000542534.2	+	22	2339	c.2299G>C	c.(2299-2301)Gag>Cag	p.E767Q	JMJD7-PLA2G4B_ENST00000342159.4_Missense_Mutation_p.E767Q|PLA2G4B_ENST00000452633.1_Missense_Mutation_p.E536Q|JMJD7-PLA2G4B_ENST00000382448.4_Missense_Mutation_p.E767Q|PLA2G4B_ENST00000458483.1_Missense_Mutation_p.E536Q	NM_005090.3	NP_005081.1			phospholipase A2, group IVB (cytosolic)														all_cancers(109;1.84e-13)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		all cancers(2;1.08e-30)|Epithelial(2;1.43e-22)|OV - Ovarian serous cystadenocarcinoma(18;1.13e-17)|GBM - Glioblastoma multiforme(94;9.77e-07)|Colorectal(2;0.0129)|COAD - Colon adenocarcinoma(120;0.0371)		TGTAGACAAGGAGCAGGTCCC	0.597000													30	43					0	0	1	0	0
ACBD4	79777	broad.mit.edu	37	17	43215295	43215295	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:43215295C>T	ENST00000398322.3	+	7	1047	c.589C>T	c.(589-591)Cgg>Tgg	p.R197W	ACBD4_ENST00000431281.1_Silent_p.S209S|ACBD4_ENST00000591859.1_Silent_p.S209S|ACBD4_ENST00000591136.1_3'UTR|ACBD4_ENST00000376955.4_Silent_p.S193S|ACBD4_ENST00000321854.8_Missense_Mutation_p.R197W|ACBD4_ENST00000586346.1_Silent_p.S209S|ACBD4_ENST00000592162.1_Missense_Mutation_p.R197W	NM_024722.2	NP_078998.1	Q8NC06	ACBD4_HUMAN	acyl-CoA binding domain containing 4	197							fatty-acyl-CoA binding			kidney(1)|lung(3)|ovary(1)	5						GACAGAGCAGCGGGCAGCATC	0.607000													7	21					0	0	1	0	0
OR10J3	441911	broad.mit.edu	37	1	159283974	159283974	+	Missense_Mutation	SNP	A	A	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:159283974A>G	ENST00000332217.5	-	1	475	c.476T>C	c.(475-477)gTc>gCc	p.V159A		NM_001004467.1	NP_001004467.1	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J, member 3	159					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(19)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	47	all_hematologic(112;0.0429)					TGTTACTTGGACAATGGCCAT	0.527000													29	35					0	0	1	0	0
SWSAP1	126074	broad.mit.edu	37	19	11486494	11486494	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:11486494C>T	ENST00000312423.2	+	2	551	c.492C>T	c.(490-492)gcC>gcT	p.A164A		NM_175871.3	NP_787067.2	Q6NVH7	CS039_HUMAN	SWIM-type zinc finger 7 associated protein 1	164																	ATTTTCCTGCCCAGTGCTGGC	0.667000													6	32					0	0	1	0	0
PPL	5493	broad.mit.edu	37	16	4949357	4949357	+	Missense_Mutation	SNP	A	A	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:4949357A>G	ENST00000345988.2	-	7	724	c.635T>C	c.(634-636)cTg>cCg	p.L212P	PPL_ENST00000590782.2_Missense_Mutation_p.L210P	NM_002705.4	NP_002696	O60437	PEPL_HUMAN	periplakin	212					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						CAGCGAACTCAGGTGCTGCTG	0.647000													6	22					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13616823	13616823	+	Silent	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:13616823G>C	ENST00000360228.5	-	1	215	c.216C>G	c.(214-216)ctC>ctG	p.L72L	CACNA1A_ENST00000573710.2_Silent_p.L72L	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	72					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GGTTAACCGTGAGGCAGTTCT	0.572000													7	24					0	0	1	0	0
WDR48	57599	broad.mit.edu	37	3	39104607	39104607	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:39104607G>A	ENST00000302313.5	+	2	143	c.115G>A	c.(115-117)Gat>Aat	p.D39N	WDR48_ENST00000418020.1_5'UTR|WDR48_ENST00000396258.3_5'UTR|WDR48_ENST00000544962.1_Intron	NM_020839.2	NP_065890.1	Q8TAF3	WDR48_HUMAN	WD repeat domain 48	39					interspecies interaction between organisms|protein deubiquitination	lysosome|nucleus	protein binding			breast(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		TCTGCAGCTGGATCCAGCACT	0.403000													28	84					0	0	1	0	0
CDH26	60437	broad.mit.edu	37	20	58545232	58545232	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr20:58545232C>T	ENST00000348616.4	+	3	522	c.222C>T	c.(220-222)ctC>ctT	p.L74L	CDH26_ENST00000244047.5_Silent_p.L74L	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	74	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			TTCCCAAACTCATTGGTGAGG	0.507000													24	60					0	0	1	0	0
SNTA1	6640	broad.mit.edu	37	20	32000148	32000148	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr20:32000148C>T	ENST00000217381.2	-	5	1265	c.994G>A	c.(994-996)Gag>Aag	p.E332K		NM_003098.2	NP_003089.1	Q13424	SNTA1_HUMAN	syntrophin, alpha 1	332	PH 2.				muscle contraction	cell junction|cytoplasm|cytoskeleton|sarcolemma	actin binding|calmodulin binding			breast(1)|large_intestine(4)|liver(1)|lung(4)|skin(1)|stomach(1)|urinary_tract(1)	13						CTCAGGGCCTCGCGGGTCTCG	0.637000													9	6					0	0	1	0	0
ASXL1	171023	broad.mit.edu	37	20	31019450	31019450	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr20:31019450C>T	ENST00000375687.4	+	10	1371	c.947C>T	c.(946-948)gCg>gTg	p.A316V	ASXL1_ENST00000306058.5_Missense_Mutation_p.A311V	NM_015338.5	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 (Drosophila)	316					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(655)|kidney(5)|large_intestine(18)|liver(1)|lung(27)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	722						TTTACCCATGCGGCTCAGAGC	0.532000			"""F, N, Mis"""		"""MDS, CMML"""								13	60					0	0	1	0	0
TXNDC16	57544	broad.mit.edu	37	14	52907320	52907320	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr14:52907320C>G	ENST00000281741.4	-	19	2336	c.1965G>C	c.(1963-1965)caG>caC	p.Q655H	TXNDC16_ENST00000554399.1_5'UTR	NM_001160047.1|NM_020784.2	NP_001153519.1|NP_065835.2	Q9P2K2	TXD16_HUMAN	thioredoxin domain containing 16	655					cell redox homeostasis	extracellular region				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|prostate(3)|skin(1)	21	Breast(41;0.0716)					CCAAGTATTTCTGCTTTACCA	0.294000													16	18					0	0	1	0	0
MICAL2	9645	broad.mit.edu	37	11	12243284	12243284	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:12243284C>A	ENST00000256194.4	+	10	1588	c.1300C>A	c.(1300-1302)Ccc>Acc	p.P434T	MICAL2_ENST00000342902.5_Missense_Mutation_p.P434T|MICAL2_ENST00000527546.1_Missense_Mutation_p.P434T|MICAL2_ENST00000537344.1_Missense_Mutation_p.P434T|MICAL2_ENST00000379612.3_Missense_Mutation_p.P434T	NM_001282663.1|NM_014632.2	NP_001269592.1|NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	434						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		GGGCACCCCTCCCCTGGAGCT	0.617000													12	30					2.68362e-12	2.84556e-12	1	1	0
PLEKHG1	57480	broad.mit.edu	37	6	151054826	151054826	+	Silent	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:151054826C>G	ENST00000367328.1	+	3	321	c.9C>G	c.(7-9)ctC>ctG	p.L3L	PLEKHG1_ENST00000358517.2_Silent_p.L3L	NM_001029884.1	NP_001025055.1	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 1	3					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(19)|ovary(5)|prostate(4)|stomach(1)|urinary_tract(3)	53			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		CAATGGAGCTCTCTGATAGTG	0.537000													9	39					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62845470	62845470	+	Missense_Mutation	SNP	A	A	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr4:62845470A>T	ENST00000512091.2	+	17	3538	c.2791A>T	c.(2791-2793)Atc>Ttc	p.I931F	LPHN3_ENST00000506700.1_Missense_Mutation_p.I931F|LPHN3_ENST00000514157.1_Missense_Mutation_p.I931F|LPHN3_ENST00000514996.1_Missense_Mutation_p.I931F|LPHN3_ENST00000508693.1_Missense_Mutation_p.I999F|LPHN3_ENST00000508946.1_Missense_Mutation_p.I931F|LPHN3_ENST00000506746.1_Missense_Mutation_p.I999F|LPHN3_ENST00000507164.1_Missense_Mutation_p.I999F|LPHN3_ENST00000511324.1_Missense_Mutation_p.I999F|LPHN3_ENST00000507625.1_Missense_Mutation_p.I999F|LPHN3_ENST00000509896.1_Missense_Mutation_p.I999F|LPHN3_ENST00000545650.1_Missense_Mutation_p.I931F|LPHN3_ENST00000514591.1_Missense_Mutation_p.I931F|LPHN3_ENST00000504896.1_Missense_Mutation_p.I931F|LPHN3_ENST00000506720.1_Missense_Mutation_p.I999F			Q9HAR2	LPHN3_HUMAN	latrophilin 3						neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						CCTGATTGGGATCAACCGAAC	0.448000													26	82					0	0	1	0	0
HAUS6	54801	broad.mit.edu	37	9	19076660	19076660	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr9:19076660G>C	ENST00000380502.3	-	11	1701	c.1234C>G	c.(1234-1236)Cct>Gct	p.P412A	HAUS6_ENST00000380496.1_Missense_Mutation_p.P276A	NM_001270890.1|NM_017645.4	NP_001257819.1|NP_060115.3	Q7Z4H7	HAUS6_HUMAN	HAUS augmin-like complex, subunit 6	412					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleus|spindle				autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TCTGAGGCAGGATCAAACGAA	0.343000													19	16					0	0	1	0	0
HIST1H2BL	8340	broad.mit.edu	37	6	27775613	27775613	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:27775613C>T	ENST00000377401.2	-	1	96	c.72G>A	c.(70-72)aaG>aaA	p.K24K		NM_003519.3	NP_003510.1	Q99880	H2B1L_HUMAN	histone cluster 1, H2bl	24					nucleosome assembly	nucleosome|nucleus	DNA binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(7)|urinary_tract(1)	12						TGCCATCCTTCTTCTGGGCCT	0.567000													63	103					0	0	1	0	0
GBF1	8729	broad.mit.edu	37	10	104129142	104129142	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:104129142G>C	ENST00000369983.3	+	24	3405	c.3145G>C	c.(3145-3147)Gag>Cag	p.E1049Q		NM_001199378.1|NM_001199379.1|NM_004193.2	NP_001186307.1|NP_001186308.1|NP_004184.1	Q92538	GBF1_HUMAN	golgi brefeldin A resistant guanine nucleotide exchange factor 1	1049					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(14)|kidney(8)|large_intestine(15)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	71		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		GGCTATGATAGAGGTAATTCT	0.493000													6	17					0	0	1	0	0
SPATA5	166378	broad.mit.edu	37	4	123844362	123844362	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr4:123844362C>G	ENST00000274008.4	+	1	134	c.65C>G	c.(64-66)tCt>tGt	p.S22C	SPATA5_ENST00000422835.2_3'UTR	NM_145207.2	NP_660208.2	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5						cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24						TCCTTGCCCTCTGCTGCTTCC	0.532000													40	183					0	0	1	0	0
ACOT7	11332	broad.mit.edu	37	1	6387467	6387467	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:6387467G>A	ENST00000361521.4	-	5	1508	c.517C>T	c.(517-519)Cgg>Tgg	p.R173W	ACOT7_ENST00000608083.1_Missense_Mutation_p.R141W|ACOT7_ENST00000377845.3_Missense_Mutation_p.R153W|ACOT7_ENST00000541130.1_Missense_Mutation_p.R153W|ACOT7_ENST00000377855.2_Missense_Mutation_p.R183W|ACOT7_ENST00000377842.3_Missense_Mutation_p.R132W|ACOT7_ENST00000545482.1_Missense_Mutation_p.R68W	NM_007274.3	NP_009205.3	O00154	BACH_HUMAN	acyl-CoA thioesterase 7	183						mitochondrion|nucleus	carboxylesterase activity|fatty-acyl-CoA binding|palmitoyl-CoA hydrolase activity			kidney(1)|large_intestine(3)|lung(10)|pancreas(1)|prostate(1)	16	Ovarian(185;0.0634)|all_lung(157;0.175)	all_cancers(23;1.42e-38)|all_epithelial(116;3.96e-23)|all_lung(118;3.69e-08)|Lung NSC(185;8.52e-07)|all_hematologic(16;6.92e-06)|Colorectal(325;4.53e-05)|Acute lymphoblastic leukemia(12;5e-05)|all_neural(13;0.000164)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0393)|Medulloblastoma(700;0.211)		Epithelial(90;9.16e-37)|GBM - Glioblastoma multiforme(13;5.89e-29)|OV - Ovarian serous cystadenocarcinoma(86;7.63e-19)|Colorectal(212;1.27e-07)|COAD - Colon adenocarcinoma(227;2.06e-05)|Kidney(185;7.74e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00129)|BRCA - Breast invasive adenocarcinoma(365;0.00132)|STAD - Stomach adenocarcinoma(132;0.00195)|READ - Rectum adenocarcinoma(331;0.0481)		TGCTCCTGCCGGGAATACTGC	0.627000													8	13					0	0	1	0	0
CD177	57126	broad.mit.edu	37	19	43866374	43866374	+	RNA	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:43866374G>A	ENST00000378009.4	+	0	1377				CD177_ENST00000607517.1_RNA|CTC-490G23.4_ENST00000607109.1_RNA	NM_020406.2	NP_065139.2	Q8N6Q3	CD177_HUMAN	CD177 molecule						blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Prostate(69;0.00682)				CTCTCAGCATGAGGGAGGTGG	0.617000													6	41					0	0	1	0	0
SERPINF2	5345	broad.mit.edu	37	17	1657612	1657612	+	Silent	SNP	C	C	T	rs147941157		TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:1657612C>T	ENST00000324015.3	+	10	1337	c.1260C>T	c.(1258-1260)ttC>ttT	p.F420F	SERPINF2_ENST00000382061.4_Silent_p.F420F|SERPINF2_ENST00000450523.2_Silent_p.F356F	NM_000934.3	NP_000925.2	P08697	A2AP_HUMAN	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	420					acute-phase response|fibrinolysis|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			breast(2)|endometrium(1)|kidney(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)	Streptokinase(DB00086)	TCTTCATCTTCGAGGACACCA	0.652000													42	44					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2820800	2820800	+	Missense_Mutation	SNP	G	G	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:2820800G>T	ENST00000520002.1	-	61	9956	c.9401C>A	c.(9400-9402)gCc>gAc	p.A3134D	CSMD1_ENST00000602723.1_Missense_Mutation_p.A2957D|CSMD1_ENST00000537824.1_Missense_Mutation_p.A3133D|CSMD1_ENST00000602557.1_Missense_Mutation_p.A3134D|CSMD1_ENST00000542608.1_Missense_Mutation_p.A2956D|CSMD1_ENST00000400186.3_Missense_Mutation_p.A2957D			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3134	Sushi 25.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GGAGAGGATGGCGGAGTGAGA	0.577000													13	48					0.000219431	0.000223366	1	1	0
GPR128	84873	broad.mit.edu	37	3	100368638	100368638	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:100368638C>G	ENST00000273352.3	+	11	1634	c.1366C>G	c.(1366-1368)Cag>Gag	p.Q456E	GPR128_ENST00000475887.1_Missense_Mutation_p.Q161E	NM_032787.2	NP_116176.2	Q96K78	GP128_HUMAN	G protein-coupled receptor 128	456					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	56						AGTTATATTTCAGATTGTCAC	0.373000													29	42					0	0	1	0	0
WIZ	58525	broad.mit.edu	37	19	15537910	15537910	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:15537910C>T	ENST00000389282.4	-	6	3748	c.3535G>A	c.(3535-3537)Gaa>Aaa	p.E1179K	WIZ_ENST00000599686.3_Missense_Mutation_p.E363K|WIZ_ENST00000263381.7_Missense_Mutation_p.E322K|WIZ_ENST00000545156.1_Missense_Mutation_p.E493K|WIZ_ENST00000599910.2_Missense_Mutation_p.E496K			O95785	WIZ_HUMAN	widely interspaced zinc finger motifs	1179						nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	24						CGTATTTGTTCAGGCTTCAGC	0.632000													14	30					0	0	1	0	0
LECT2	3950	broad.mit.edu	37	5	135286999	135286999	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:135286999C>G	ENST00000274507.1	-	3	402	c.202G>C	c.(202-204)Gca>Cca	p.A68P	LECT2_ENST00000514447.2_Missense_Mutation_p.A68P|FBXL21_ENST00000467490.1_RNA|LECT2_ENST00000512872.1_5'UTR|LECT2_ENST00000522943.1_Missense_Mutation_p.A68P|LECT2_ENST00000471827.1_5'UTR	NM_002302.2	NP_002293.2	O14960	LECT2_HUMAN	leukocyte cell-derived chemotaxin 2	68					chemotaxis|skeletal system development	cytoplasm|extracellular space				large_intestine(1)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTGAATGGTGCGTACACAGTA	0.453000													10	44					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6219594	6219594	+	Missense_Mutation	SNP	C	C	T	rs61753995		TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:6219594C>T	ENST00000261405.5	-	5	732	c.478G>A	c.(478-480)Ggg>Agg	p.G160R	VWF_ENST00000572068.1_Missense_Mutation_p.G197R	NM_000552.3	NP_000543	P04275	VWF_HUMAN	von Willebrand factor	160	VWFD 1.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	CCACACAGCCCGCAGGTCTTG	0.488000													13	103					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75858195	75858195	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:75858195G>C	ENST00000322507.8	-	22	4475	c.4166C>G	c.(4165-4167)tCt>tGt	p.S1389C	COL12A1_ENST00000483888.2_Missense_Mutation_p.S1389C|COL12A1_ENST00000345356.6_Missense_Mutation_p.S225C|COL12A1_ENST00000416123.2_Missense_Mutation_p.S1389C	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	1389	Fibronectin type-III 9.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						AACTAAGTTAGAAGGTGCTTC	0.368000													6	26					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	29001305	29001305	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr13:29001305G>C	ENST00000282397.4	-	10	1678	c.1427C>G	c.(1426-1428)tCc>tGc	p.S476C	FLT1_ENST00000539099.1_Missense_Mutation_p.S476C|FLT1_ENST00000541932.1_Missense_Mutation_p.S476C	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	476	Ig-like C2-type 5.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	CCTTGCTTCGGAATGATTATG	0.428000													22	80					0	0	1	0	0
CD2BP2	10421	broad.mit.edu	37	16	30364878	30364878	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:30364878C>G	ENST00000305596.3	-	5	794	c.619G>C	c.(619-621)Gac>Cac	p.D207H	CD2BP2_ENST00000569466.1_Missense_Mutation_p.D207H	NM_006110.2	NP_006101.1	O95400	CD2B2_HUMAN	CD2 (cytoplasmic tail) binding protein 2	207					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			breast(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)	15						ACCATCTGGTCGGCCAACCCG	0.652000													10	22					0	0	1	0	0
RNF169	254225	broad.mit.edu	37	11	74459943	74459943	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:74459943G>A	ENST00000299563.4	+	1	31	c.18G>A	c.(16-18)ccG>ccA	p.P6P		NM_001098638.1	NP_001092108.1	Q8NCN4	RN169_HUMAN	ring finger protein 169	6							zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|urinary_tract(1)	15						CTGCAGGTCCGAGTACTCGGG	0.692000													3	5					0	0	1	0	0
KLHL34	257240	broad.mit.edu	37	X	21674415	21674415	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chrX:21674415C>A	ENST00000379499.2	-	1	2033	c.1492G>T	c.(1492-1494)Gtc>Ttc	p.V498F		NM_153270.1	NP_695002.1	Q8N239	KLH34_HUMAN	kelch-like family member 34	498										cervix(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(11)|ovary(2)|urinary_tract(1)	26						GGGCCCAGGACGTATAAGTCC	0.672000													2	2					0.0784	0.0785064	1	1	0
SLC4A9	83697	broad.mit.edu	37	5	139748223	139748223	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:139748223C>T	ENST00000230993.6	+	17	2513	c.2478C>T	c.(2476-2478)atC>atT	p.I826I	SLC4A9_ENST00000506757.2_Silent_p.I802I|SLC4A9_ENST00000506545.1_Silent_p.I739I|SLC4A9_ENST00000507527.1_Silent_p.I826I|SLC4A9_ENST00000432095.2_Silent_p.I788I	NM_001258428.1	NP_001245357.1	Q96Q91	B3A4_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 9	826	Membrane (anion exchange).					integral to membrane|plasma membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGCCTCCATCTTCCTGGCAC	0.522000													18	18					0	0	1	0	0
DNLZ	728489	broad.mit.edu	37	9	139257549	139257549	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr9:139257549G>C	ENST00000371738.3	-	2	334	c.260C>G	c.(259-261)tCc>tGc	p.S87C	DNLZ_ENST00000371739.3_Intron	NM_001080849.1	NP_001074318.1	Q5SXM8	DNLZ_HUMAN	DNL-type zinc finger	87							metal ion binding			central_nervous_system(1)|prostate(1)	2		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.42e-06)|Epithelial(140;3.3e-06)		GGCCAGCTTGGAGATGCGCTT	0.642000													44	25					0	0	1	0	0
IGKV1-17	28937	broad.mit.edu	37	2	89417258	89417258	+	RNA	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:89417258G>A	ENST00000490686.1	-	0	77																											CCTTACCTGGGAACCAGAGCA	0.507000													7	151					0	0	1	0	0
SYNJ2	8871	broad.mit.edu	37	6	158517289	158517289	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:158517289G>A	ENST00000355585.4	+	27	4459	c.4384G>A	c.(4384-4386)Gag>Aag	p.E1462K	SYNJ2_ENST00000367112.1_Missense_Mutation_p.E547K|SYNJ2_ENST00000367122.2_Missense_Mutation_p.E1417K	NM_001178088.1|NM_003898.3	NP_001171559.1|NP_003889.1	O15056	SYNJ2_HUMAN	synaptojanin 2	1462							nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			biliary_tract(1)|endometrium(9)|kidney(3)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		TGCCAAGGCAGAGCTGCCACC	0.522000													13	19					0	0	1	0	0
L3MBTL3	84456	broad.mit.edu	37	6	130442070	130442070	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:130442070G>C	ENST00000529410.1	+	22	2412	c.1933G>C	c.(1933-1935)Gaa>Caa	p.E645Q	L3MBTL3_ENST00000361794.2_Missense_Mutation_p.E645Q|L3MBTL3_ENST00000368136.2_Missense_Mutation_p.E645Q|L3MBTL3_ENST00000526019.1_Missense_Mutation_p.E620Q|L3MBTL3_ENST00000368139.2_Missense_Mutation_p.E620Q|L3MBTL3_ENST00000533560.1_Missense_Mutation_p.E620Q			Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 (Drosophila)	645					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				cervix(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|skin(4)|stomach(1)|urinary_tract(1)	43				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		AGAGAGAACAGAAAGTGAAAT	0.318000													12	82					0	0	1	0	0
OR4K17	390436	broad.mit.edu	37	14	20585728	20585728	+	Nonsense_Mutation	SNP	G	G	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr14:20585728G>T	ENST00000315543.4	+	1	163	c.163G>T	c.(163-165)Gag>Tag	p.E55*		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	27					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		CCAGGATGTAGAGTTTCTTCT	0.428000													28	107					4.87955e-14	5.23417e-14	1	1	0
CFL1	1072	broad.mit.edu	37	11	65623618	65623618	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:65623618C>T	ENST00000525451.2	-	3	814	c.99G>A	c.(97-99)aaG>aaA	p.K33K	CFL1_ENST00000531413.1_Silent_p.K16K|CFL1_ENST00000308162.5_Silent_p.K33K|CFL1_ENST00000524553.1_Silent_p.K16K|CFL1_ENST00000527344.1_Silent_p.K16K|CFL1_ENST00000531407.1_Silent_p.K16K|CFL1_ENST00000534769.1_Silent_p.K71K			P23528	COF1_HUMAN	cofilin 1 (non-muscle)	33	ADF-H.				actin cytoskeleton organization|anti-apoptosis|axon guidance|platelet activation|platelet degranulation|response to virus|Rho protein signal transduction	cytoplasm|cytoskeleton|nuclear matrix	actin binding			breast(1)|kidney(1)|large_intestine(2)|lung(2)	6				READ - Rectum adenocarcinoma(159;0.169)		GCACCGCCTTCTTGCGCTTCT	0.567000													40	38					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	82147760	82147760	+	Missense_Mutation	SNP	G	G	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:82147760G>T	ENST00000550584.2	-	2	536	c.241C>A	c.(241-243)Ctg>Atg	p.L81M	PPFIA2_ENST00000552948.1_Missense_Mutation_p.L81M|PPFIA2_ENST00000549325.1_Missense_Mutation_p.L81M|PPFIA2_ENST00000333447.7_Missense_Mutation_p.L81M|PPFIA2_ENST00000548586.1_Missense_Mutation_p.L81M|PPFIA2_ENST00000549396.1_Missense_Mutation_p.L81M	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	339										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						ACCTGTGGCAGGGCTGAATTG	0.453000													5	9					1.23904e-05	1.27533e-05	1	1	0
PCDHB14	56122	broad.mit.edu	37	5	140603972	140603972	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:140603972G>A	ENST00000239449.4	+	1	895	c.895G>A	c.(895-897)Ggg>Agg	p.G299R	PCDHB14_ENST00000515856.2_Missense_Mutation_p.G146R	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		299	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCAATATCTGGGGAAGTTAA	0.363000													24	33					0	0	1	0	0
CWC22	57703	broad.mit.edu	37	2	180815373	180815373	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:180815373G>A	ENST00000410053.3	-	19	2305	c.2006C>T	c.(2005-2007)tCc>tTc	p.S669F	CWC22_ENST00000295749.6_Missense_Mutation_p.S669F	NM_020943.2	NP_065994.1	Q9HCG8	CWC22_HUMAN	CWC22 spliceosome-associated protein homolog (S. cerevisiae)	669	Ser-rich.					catalytic step 2 spliceosome	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(8)|liver(1)|lung(8)|stomach(1)	30						AGAGGAAGAGGATGGGGAGGA	0.458000													29	18					0	0	1	0	0
TANGO2	128989	broad.mit.edu	37	22	20024596	20024596	+	Nonsense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr22:20024596C>G	ENST00000456048.1	+	1	50	c.50C>G	c.(49-51)tCa>tGa	p.S17*	TANGO2_ENST00000398042.2_Intron|TANGO2_ENST00000432883.1_Intron|TANGO2_ENST00000447208.2_Intron|TANGO2_ENST00000479679.1_Intron|TANGO2_ENST00000401886.1_Intron|TANGO2_ENST00000327374.4_Intron|TANGO2_ENST00000434570.2_Nonsense_Mutation_p.S53*|TANGO2_ENST00000401833.1_Nonsense_Mutation_p.S53*|TANGO2_ENST00000420290.2_Intron	NM_001283129.1	NP_001270058.1			transport and golgi organization 2 homolog (Drosophila)																		CGTGAAGACTCAGCCACAGAA	0.602000													12	57					0	0	1	0	0
ALDH5A1	7915	broad.mit.edu	37	6	24503625	24503625	+	Silent	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:24503625C>G	ENST00000357578.3	+	3	718	c.573C>G	c.(571-573)ctC>ctG	p.L191L	ALDH5A1_ENST00000491546.1_Silent_p.L163L|ALDH5A1_ENST00000348925.2_Silent_p.L191L|ALDH5A1_ENST00000546278.1_Silent_p.L103L	NM_001080.3	NP_001071.1	P51649	SSDH_HUMAN	aldehyde dehydrogenase 5 family, member A1	191					acetate metabolic process|central nervous system development|galactosylceramide metabolic process|gamma-aminobutyric acid catabolic process|glucose metabolic process|glutamate metabolic process|glutamine metabolic process|glutathione metabolic process|glycerophospholipid metabolic process|neurotransmitter catabolic process|neurotransmitter secretion|protein homotetramerization|respiratory electron transport chain|short-chain fatty acid metabolic process|succinate metabolic process	mitochondrial matrix|soluble fraction	succinate-semialdehyde dehydrogenase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(7)|skin(2)|urinary_tract(1)	20					Chlormerodrin(DB00534)|NADH(DB00157)|Succinic acid(DB00139)	CCCTGGTCCTCAAGCAGCCCA	0.557000													14	13					0	0	1	0	0
TMBIM6	7009	broad.mit.edu	37	12	50149465	50149465	+	Silent	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:50149465G>C	ENST00000423828.1	+	4	715	c.387G>C	c.(385-387)ctG>ctC	p.L129L	TMBIM6_ENST00000549385.1_Silent_p.L71L|TMBIM6_ENST00000395006.4_Silent_p.L71L|TMBIM6_ENST00000552699.1_Silent_p.L129L|TMBIM6_ENST00000267115.5_Silent_p.L71L|TMBIM6_ENST00000547798.1_Silent_p.L34L	NM_001098576.1	NP_001092046.1	P55061	BI1_HUMAN	transmembrane BAX inhibitor motif containing 6	71					apoptosis|negative regulation of apoptosis	endoplasmic reticulum|insoluble fraction|integral to plasma membrane|nucleus				lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	6						TGATTTGGCTGATGGCAACAC	0.408000													41	173					0	0	1	0	0
KPNB1	3837	broad.mit.edu	37	17	45736018	45736018	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:45736018G>C	ENST00000290158.4	+	5	1035	c.628G>C	c.(628-630)Gat>Cat	p.D210H	KPNB1_ENST00000540627.1_Missense_Mutation_p.D65H|KPNB1_ENST00000577918.1_3'UTR|KPNB1_ENST00000535458.2_Missense_Mutation_p.D65H|KPNB1_ENST00000537679.1_Missense_Mutation_p.D65H	NM_001276453.1|NM_002265.4	NP_001263382.1|NP_002256.2	Q14974	IMB1_HUMAN	karyopherin (importin) beta 1	210					DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|protein import into nucleus, translocation|ribosomal protein import into nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein domain specific binding|zinc ion binding			breast(1)|ovary(1)|pancreas(1)|skin(1)	4						AGCAAACTTTGATAAAGAGGT	0.358000													41	32					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29625885	29625885	+	Missense_Mutation	SNP	A	A	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr20:29625885A>T	ENST00000278882.3	+	5	509	c.129A>T	c.(127-129)aaA>aaT	p.K43N	FRG1B_ENST00000439954.2_Missense_Mutation_p.K48N|FRG1B_ENST00000358464.4_Missense_Mutation_p.K43N														p.K43N(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TCGCCCTGAAATCTGGCTATG	0.353000													6	91					0	0	1	0	0
ZBTB45	84878	broad.mit.edu	37	19	59025453	59025453	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:59025453C>G	ENST00000594051.1	-	3	1984	c.1504G>C	c.(1504-1506)Gag>Cag	p.E502Q	ZBTB45_ENST00000354590.3_Missense_Mutation_p.E502Q|ZBTB45_ENST00000600990.1_Missense_Mutation_p.E502Q			Q96K62	ZBT45_HUMAN	zinc finger and BTB domain containing 45	502					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|lung(5)|urinary_tract(1)	11		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0165)|Lung(386;0.18)		AGGTGGCGCTCCAGCAGCGCG	0.756000													3	5					0	0	1	0	0
SKP1	6500	broad.mit.edu	37	5	133494205	133494205	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:133494205C>G	ENST00000353411.6	-	5	580	c.397G>C	c.(397-399)Gag>Cag	p.E133Q	SKP1_ENST00000521216.1_Missense_Mutation_p.E133Q|SKP1_ENST00000517625.1_Missense_Mutation_p.E133Q|SKP1_ENST00000522855.1_Missense_Mutation_p.E133Q|SKP1_ENST00000522552.1_Missense_Mutation_p.E133Q	NM_170679.2	NP_733779.1	P63208	SKP1_HUMAN	S-phase kinase-associated protein 1	133	Interaction with the F-box domain of F- box proteins (By similarity).				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|G1/S transition of mitotic cell cycle|histone H2A monoubiquitination|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|viral reproduction	cytosol|nucleoplasm|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CGAATCTCCTCAGGAGTTTTC	0.408000													28	94					0	0	1	0	0
OTUD7B	56957	broad.mit.edu	37	1	149916353	149916353	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:149916353C>G	ENST00000369135.4	-	12	2229	c.1935G>C	c.(1933-1935)caG>caC	p.Q645H		NM_020205.2	NP_064590.2	Q6GQQ9	OTU7B_HUMAN	OTU domain containing 7B						negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)			CTGCCTCCTTCTGCTTCTGTT	0.547000													58	102					0	0	1	0	0
TIMELESS	8914	broad.mit.edu	37	12	56822358	56822358	+	Silent	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:56822358C>G	ENST00000229201.4	-	12	1534	c.1380G>C	c.(1378-1380)gtG>gtC	p.V460V	TIMELESS_ENST00000554616.1_Intron|TIMELESS_ENST00000553532.1_Silent_p.V461V	NM_003920.3	NP_003911.2	Q9UNS1	TIM_HUMAN	timeless circadian clock	461					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				NS(1)|breast(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(8)|lung(14)|ovary(7)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	49						TGCTCTCCCTCACAGCCTCAT	0.562000													5	23					0	0	1	0	0
RFC3	5983	broad.mit.edu	37	13	34410251	34410251	+	Nonsense_Mutation	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr13:34410251C>A	ENST00000380071.3	+	9	1020	c.890C>A	c.(889-891)tCa>tAa	p.S297*	RFC3_ENST00000434425.1_Intron	NM_002915.3	NP_002906.1	P40938	RFC3_HUMAN	replication factor C (activator 1) 3, 38kDa	297					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|response to organophosphorus|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			lung(2)|skin(1)	3		Hepatocellular(188;0.0191)|Lung SC(185;0.0548)		all cancers(112;5.09e-06)|Epithelial(112;6.52e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00107)|OV - Ovarian serous cystadenocarcinoma(117;0.0285)|GBM - Glioblastoma multiforme(144;0.123)		GGCCTTCTCTCAGAACTGTTA	0.363000													9	35					0.00621372	0.00626465	1	1	0
RAB43	339122	broad.mit.edu	37	3	128810173	128810173	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:128810173G>A	ENST00000315150.5	-	3	705	c.405C>T	c.(403-405)ctC>ctT	p.L135L	ISY1-RAB43_ENST00000418265.1_3'UTR|RAB43_ENST00000393304.1_Silent_p.L135L|RAB43_ENST00000476465.1_3'UTR|RAB43_ENST00000393308.1_Silent_p.L135L|RAB43_ENST00000393305.1_Silent_p.L135L|RAB43_ENST00000393307.1_Silent_p.L135L	NM_001204888.1|NM_198490.2	NP_001191817.1|NP_940892.1	Q86YS6	RAB43_HUMAN	RAB43, member RAS oncogene family	135					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			kidney(2)|liver(1)|lung(2)|skin(1)	6						GAAGCTCGCTGAGGTCTGACT	0.632000													9	9					0	0	1	0	0
SOX6	55553	broad.mit.edu	37	11	16077389	16077389	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:16077389G>A	ENST00000352083.6	-	10	1237	c.1160C>T	c.(1159-1161)tCa>tTa	p.S387L	SOX6_ENST00000527619.1_Missense_Mutation_p.S349L|SOX6_ENST00000396356.3_Missense_Mutation_p.S387L|SOX6_ENST00000316399.6_Missense_Mutation_p.S387L|SOX6_ENST00000528429.1_Missense_Mutation_p.S387L|SOX6_ENST00000528252.1_Missense_Mutation_p.S346L			P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6	387					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|pancreas(1)|prostate(2)	43						CTGTGGAGTTGATGGCATCTT	0.498000													7	41					0	0	1	0	0
PABPC4	8761	broad.mit.edu	37	1	40038244	40038244	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:40038244C>T	ENST00000372857.3	-	2	1000	c.208G>A	c.(208-210)Gac>Aac	p.D70N	PABPC4_ENST00000372858.3_Missense_Mutation_p.D70N|RP11-69E11.8_ENST00000415255.1_RNA|PABPC4_ENST00000372862.3_Missense_Mutation_p.D70N|PABPC4_ENST00000372856.3_Missense_Mutation_p.D70N	NM_003819.3	NP_003810.1	Q13310	PABP4_HUMAN	poly(A) binding protein, cytoplasmic 4 (inducible form)	70	RRM 1.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|prostate(1)|skin(3)	21	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			TTCATGGTGTCCAAAGCCCGC	0.463000													14	54					0	0	1	0	0
HGSNAT	138050	broad.mit.edu	37	8	43033261	43033261	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:43033261C>T	ENST00000458501.2	+	10	980	c.980C>T	c.(979-981)tCt>tTt	p.S327F	HGSNAT_ENST00000379644.4_Missense_Mutation_p.S299F			Q68CP4	HGNAT_HUMAN	heparan-alpha-glucosaminide N-acetyltransferase	327					lysosomal transport|protein oligomerization	integral to membrane|lysosomal membrane	heparan-alpha-glucosaminide N-acetyltransferase activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(6)	13	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			TCGATGACTTCTATACTGCAA	0.343000													20	65					0	0	1	0	0
CHRNE	1145	broad.mit.edu	37	17	4804916	4804916	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:4804916G>C	ENST00000293780.4	-	6	515	c.505C>G	c.(505-507)Cag>Gag	p.Q169E	CHRNE_ENST00000575637.1_5'UTR|C17orf107_ENST00000381365.3_3'UTR	NM_000080.3	NP_000071.1	Q04844	ACHE_HUMAN	cholinergic receptor, nicotinic, epsilon (muscle)	169					muscle contraction|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(5)|lung(3)|prostate(1)	12						TTGTACGTCTGAGAGCTGCGG	0.617000													16	14					0	0	1	0	0
COL27A1	85301	broad.mit.edu	37	9	117044574	117044574	+	Silent	SNP	A	A	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr9:117044574A>G	ENST00000356083.3	+	38	4126	c.3735A>G	c.(3733-3735)tcA>tcG	p.S1245S		NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1	1245	Collagen-like 10.|Pro-rich.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						AAGGAAAATCAGGGAAGCAAG	0.582000													3	29					0	0	1	0	0
KIAA2018	205717	broad.mit.edu	37	3	113379739	113379739	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:113379739C>T	ENST00000316407.4	-	7	1200	c.790G>A	c.(790-792)Gag>Aag	p.E264K	KIAA2018_ENST00000478658.1_Missense_Mutation_p.E264K|KIAA2018_ENST00000491165.1_Intron	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	264					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						TGGTGAGGCTCAGATTCAATT	0.408000													22	42					0	0	1	0	0
TRPC7	57113	broad.mit.edu	37	5	135567188	135567188	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:135567188C>T	ENST00000513104.1	-	8	2176	c.1894G>A	c.(1894-1896)Gaa>Aaa	p.E632K	TRPC7_ENST00000355180.3_Missense_Mutation_p.E571K|TRPC7_ENST00000426057.2_Missense_Mutation_p.E516K	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	632					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GAGATTACTTCAGATAAGCCG	0.413000													7	18					0	0	1	0	0
TNFAIP8L3	388121	broad.mit.edu	37	15	51350635	51350635	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:51350635C>G	ENST00000327536.5	-	3	421	c.322G>C	c.(322-324)Gat>Cat	p.D108H	RP11-108K3.1_ENST00000559909.1_lincRNA	NM_207381.2	NP_997264.2	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein 8-like 3	108										endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	11				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)		CTAAAAACATCAGGACCTATG	0.343000													5	15					0	0	1	0	0
CALCRL	10203	broad.mit.edu	37	2	188248011	188248011	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:188248011C>T	ENST00000409998.1	-	6	854	c.73G>A	c.(73-75)Gaa>Aaa	p.E25K	CALCRL_ENST00000392370.3_Missense_Mutation_p.E25K|AC007319.1_ENST00000412276.1_RNA|CALCRL_ENST00000410068.1_Missense_Mutation_p.E25K|AC007319.1_ENST00000453517.1_RNA			Q16602	CALRL_HUMAN	calcitonin receptor-like	25						integral to plasma membrane				endometrium(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)			GGACTCTCTTCTAATTCTGCT	0.348000													22	16					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181702026	181702026	+	Nonsense_Mutation	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:181702026C>A	ENST00000526775.1	+	19	2912	c.2747C>A	c.(2746-2748)tCa>tAa	p.S916*	CACNA1E_ENST00000367570.1_Nonsense_Mutation_p.S935*|CACNA1E_ENST00000360108.3_Nonsense_Mutation_p.S916*|CACNA1E_ENST00000358338.5_Nonsense_Mutation_p.S867*|CACNA1E_ENST00000367573.2_Nonsense_Mutation_p.S935*|CACNA1E_ENST00000367567.4_Nonsense_Mutation_p.S542*|CACNA1E_ENST00000357570.5_Nonsense_Mutation_p.S886*	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	935					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GAGTCCTCTTCAGCCTCCCGG	0.647000													36	98					1.03484e-13	1.10843e-13	1	1	0
QRICH1	54870	broad.mit.edu	37	3	49083976	49083976	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:49083976G>A	ENST00000395443.2	-	5	2025	c.1553C>T	c.(1552-1554)tCc>tTc	p.S518F	QRICH1_ENST00000479449.1_5'UTR|QRICH1_ENST00000424300.1_Missense_Mutation_p.S518F|QRICH1_ENST00000357496.2_Missense_Mutation_p.S518F	NM_198880.1	NP_942581.1	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	518										breast(2)|endometrium(5)|large_intestine(8)|lung(8)|ovary(1)|skin(1)	25				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		CACAGCAGAGGAGATGAGATC	0.498000													28	45					0	0	1	0	0
MYBPC3	4607	broad.mit.edu	37	11	47363703	47363703	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:47363703C>G	ENST00000399249.2	-	17	1683	c.1629G>C	c.(1627-1629)aaG>aaC	p.K543N	MYBPC3_ENST00000256993.4_Missense_Mutation_p.K542N|MYBPC3_ENST00000545968.1_Missense_Mutation_p.K543N			Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	542	Ig-like C2-type 4.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(3)|urinary_tract(2)	42				Lung(87;0.176)		CCTCCAGCTTCTTTTCTGCAG	0.607000													5	30					0	0	1	0	0
GOLGA8M	653720	broad.mit.edu	37	15	23261939	23261939	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:23261939C>T	ENST00000450802.3	+	12	1149	c.1051C>T	c.(1051-1053)Cgg>Tgg	p.R351W		NM_001282468.1|NM_001282472.1|NM_001282484.1|NM_001282490.1|NM_001282493.1|NM_001282494.1	NP_001269397.1|NP_001269401.1|NP_001269413.1|NP_001269419.1|NP_001269422.1|NP_001269423.1																					AGAGAGGCTTCGGAAGCAGGA	0.592000													4	18					0	0	1	0	0
KCNRG	283518	broad.mit.edu	37	13	50589715	50589715	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr13:50589715C>T	ENST00000360473.4	+	1	326	c.86C>T	c.(85-87)tCt>tTt	p.S29F	TRIM13_ENST00000478111.1_Intron|KCNRG_ENST00000312942.1_Missense_Mutation_p.S29F|TRIM13_ENST00000378182.3_3'UTR	NM_199464.2	NP_955751.1	Q8N5I3	KCNRG_HUMAN	potassium channel regulator	29	BTB.					voltage-gated potassium channel complex	identical protein binding|voltage-gated potassium channel activity			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)	9		Acute lymphoblastic leukemia(7;3.41e-06)|Lung NSC(96;3.08e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.48e-10)|COAD - Colon adenocarcinoma(199;0.204)		TTTCCTGCTTCTCGTTTGGCA	0.423000													12	55					0	0	1	0	0
MANBA	4126	broad.mit.edu	37	4	103556106	103556106	+	Nonsense_Mutation	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr4:103556106C>A	ENST00000226578.4	-	16	2353	c.2254G>T	c.(2254-2256)Gag>Tag	p.E752*	MANBA_ENST00000505239.1_Nonsense_Mutation_p.E695*	NM_005908.3	NP_005899.3	O00462	MANBA_HUMAN	mannosidase, beta A, lysosomal	752					carbohydrate metabolic process|protein modification process	lysosome	beta-mannosidase activity|cation binding			cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;4.44e-08)		GACACTGGCTCCTCATAAAGG	0.527000													10	14					0.0581538	0.0583118	1	1	0
HIVEP2	3097	broad.mit.edu	37	6	143095204	143095204	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:143095204G>C	ENST00000367603.2	-	5	1414	c.672C>G	c.(670-672)ttC>ttG	p.F224L	HIVEP2_ENST00000367604.1_Missense_Mutation_p.F224L|HIVEP2_ENST00000012134.2_Missense_Mutation_p.F224L	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	224					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		TCTTGAAAGAGAAACCACAAG	0.453000													27	81					0	0	1	0	0
HIVEP2	3097	broad.mit.edu	37	6	143094449	143094449	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:143094449G>A	ENST00000367603.2	-	5	2169	c.1427C>T	c.(1426-1428)tCa>tTa	p.S476L	HIVEP2_ENST00000367604.1_Missense_Mutation_p.S476L|HIVEP2_ENST00000012134.2_Missense_Mutation_p.S476L	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	476					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		GATCAGCTGTGAAACAGGATC	0.478000													16	72					0	0	1	0	0
EGLN1	54583	broad.mit.edu	37	1	231557588	231557588	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:231557588C>T	ENST00000366641.3	-	1	3202	c.47G>A	c.(46-48)cGa>cAa	p.R16Q		NM_022051.2	NP_071334.1	Q9GZT9	EGLN1_HUMAN	egl-9 family hypoxia-inducible factor 1	16					negative regulation of sequence-specific DNA binding transcription factor activity|oxygen homeostasis|response to hypoxia	cytosol	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-proline dioxygenase activity|protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|urinary_tract(1)	16		Prostate(94;0.194)|Acute lymphoblastic leukemia(190;0.244)			Vitamin C(DB00126)	CTGCCGGTCTCGCTCGCTCGG	0.731000													6	2					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119750016	119750016	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:119750016G>A	ENST00000541757.1	+	16	1362	c.982G>A	c.(982-984)Ggg>Agg	p.G328R	MARCO_ENST00000327097.4_Missense_Mutation_p.G406R			Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	406	Collagen-like.				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						AGGATCTTCTGGGGAGCAAGG	0.448000													19	31					0	0	1	0	0
SEPT1	1731	broad.mit.edu	37	16	30389934	30389934	+	Missense_Mutation	SNP	T	T	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:30389934T>G	ENST00000321367.3	-	11	1200	c.1155A>C	c.(1153-1155)gaA>gaC	p.E385D	SEPT1_ENST00000605106.1_Missense_Mutation_p.E343D|SEPT1_ENST00000571393.1_Missense_Mutation_p.E338D	NM_052838.4	NP_443070.5	Q8WYJ6	SEPT1_HUMAN	septin 1	338					cell cycle|cell division	microtubule organizing center|septin complex	GTP binding|protein binding			breast(2)|endometrium(1)|large_intestine(3)|lung(15)|ovary(1)|skin(1)|urinary_tract(1)	24			Colorectal(24;0.193)			TGCTCACCTCTTCGTCTTTCT	0.667000													14	10					0	0	1	0	0
TAS1R3	83756	broad.mit.edu	37	1	1268433	1268433	+	Missense_Mutation	SNP	G	G	A	rs144635443		TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:1268433G>A	ENST00000339381.5	+	4	1440	c.1408G>A	c.(1408-1410)Gac>Aac	p.D470N		NM_152228.1	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3	470					detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			kidney(2)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	12	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	CAGGCTCCACGACGTGGGCAG	0.657000													6	22					0	0	1	0	0
WIZ	58525	broad.mit.edu	37	19	15536424	15536424	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:15536424C>T	ENST00000389282.4	-	7	4021	c.3808G>A	c.(3808-3810)Gag>Aag	p.E1270K	WIZ_ENST00000599686.3_Missense_Mutation_p.E454K|WIZ_ENST00000263381.7_Missense_Mutation_p.E413K|WIZ_ENST00000545156.1_Missense_Mutation_p.E584K|WIZ_ENST00000599910.2_Missense_Mutation_p.E587K			O95785	WIZ_HUMAN	widely interspaced zinc finger motifs	1270						nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	24						TTGAGGATCTCTCGCAGTGTG	0.647000													7	19					0	0	1	0	0
KCNRG	283518	broad.mit.edu	37	13	50589677	50589677	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr13:50589677C>G	ENST00000360473.4	+	1	288	c.48C>G	c.(46-48)ttC>ttG	p.F16L	TRIM13_ENST00000478111.1_Intron|KCNRG_ENST00000312942.1_Missense_Mutation_p.F16L|TRIM13_ENST00000378182.3_3'UTR	NM_199464.2	NP_955751.1	Q8N5I3	KCNRG_HUMAN	potassium channel regulator	16	BTB.					voltage-gated potassium channel complex	identical protein binding|voltage-gated potassium channel activity			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)	9		Acute lymphoblastic leukemia(7;3.41e-06)|Lung NSC(96;3.08e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.48e-10)|COAD - Colon adenocarcinoma(199;0.204)		GGAAGATATTCACGACAAGGT	0.448000													13	45					0	0	1	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19642312	19642312	+	Missense_Mutation	SNP	C	C	T	rs146494364		TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr21:19642312C>T	ENST00000284885.3	-	25	3067	c.3034G>A	c.(3034-3036)Gaa>Aaa	p.E1012K		NM_002772.2	NP_002763	P98073	ENTK_HUMAN	transmembrane protease, serine 15	1012	Peptidase S1.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						TGTATCCATTCGGTAAACCTT	0.423000													6	42					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152188119	152188119	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:152188119G>C	ENST00000368801.2	-	3	6061	c.5986C>G	c.(5986-5988)Cgc>Ggc	p.R1996G	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	1996					keratinization		calcium ion binding|protein binding	p.R1996C(1)		autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCCTGAGCGAGACTCTCGG	0.572000													11	692					0	0	1	0	0
DPP6	1804	broad.mit.edu	37	7	154672607	154672607	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:154672607G>A	ENST00000404039.1	+	21	2483	c.1896G>A	c.(1894-1896)ctG>ctA	p.L632L	DPP6_ENST00000377770.3_Silent_p.L696L|DPP6_ENST00000332007.3_Silent_p.L634L|DPP6_ENST00000427557.1_Silent_p.L589L	NM_001039350.1|NM_001936.3|NM_130797.2	NP_001034439.1|NP_001927.3|NP_570629.2	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	696					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			GGACGATGCTGAAGGAGCAGT	0.567000													4	50					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71403526	71403526	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:71403526C>T	ENST00000296755.7	+	1	466	c.168C>T	c.(166-168)atC>atT	p.I56I	MAP1B_ENST00000504183.1_3'UTR	NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	56						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		GGCGTGCCATCGGCAACATCG	0.677000													3	12					0	0	1	0	0
HRASLS	57110	broad.mit.edu	37	3	192988399	192988399	+	Missense_Mutation	SNP	C	C	G	rs151296838	by1000genomes	TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:192988399C>G	ENST00000264735.2	+	4	821	c.727C>G	c.(727-729)Cga>Gga	p.R243G	HRASLS_ENST00000602513.1_Missense_Mutation_p.R138G	NM_020386.4	NP_065119.2	Q9HDD0	HRSL1_HUMAN	HRAS-like suppressor	138										breast(1)|large_intestine(2)|lung(4)|prostate(1)|skin(2)	10	all_cancers(143;9.1e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000159)		ATAGGCCAACCGAGCGATAAG	0.383000													12	55					0	0	1	0	0
THBS2	7058	broad.mit.edu	37	6	169629702	169629702	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:169629702C>T	ENST00000366787.3	-	15	2473	c.2224G>A	c.(2224-2226)Gat>Aat	p.D742N	XXyac-YX65C7_A.2_ENST00000444188.1_RNA	NM_003247.2	NP_003238.2	P35442	TSP2_HUMAN	thrombospondin 2	742					cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			NS(3)|biliary_tract(1)|endometrium(8)|kidney(3)|large_intestine(23)|liver(1)|lung(56)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	111		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		TCATCGTCATCATCACAGGCA	0.557000													7	53					0	0	1	0	0
ANPEP	290	broad.mit.edu	37	15	90335702	90335702	+	Missense_Mutation	SNP	C	C	G	rs149334449	byFrequency	TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:90335702C>G	ENST00000300060.6	-	17	2654	c.2341G>C	c.(2341-2343)Gag>Cag	p.E781Q		NM_001150.2	NP_001141.2	P15144	AMPN_HUMAN	alanyl (membrane) aminopeptidase	781	Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	57	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	TTGGGGTTCTCCATCCACTGC	0.592000													14	37					0	0	1	0	0
KIFAP3	22920	broad.mit.edu	37	1	169930205	169930205	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:169930205C>G	ENST00000367765.1	-	18	3536	c.2035G>C	c.(2035-2037)Gac>Cac	p.D679H	KIFAP3_ENST00000538366.1_Missense_Mutation_p.D641H|KIFAP3_ENST00000367767.1_Missense_Mutation_p.D675H|KIFAP3_ENST00000540905.1_Missense_Mutation_p.D421H|KIFAP3_ENST00000361580.2_Missense_Mutation_p.D719H	NM_001204517.1	NP_001191446.1	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	719					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding	p.D719H(1)		endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(18)|prostate(2)|skin(3)|urinary_tract(2)	35	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TAGAAAAGGTCAGGTCTTTCG	0.413000													32	79					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175066594	175066594	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:175066594G>C	ENST00000239462.4	+	8	1743	c.1630G>C	c.(1630-1632)Gag>Cag	p.E544Q		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	544	Fibronectin type-III 4.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CCGGGTGACTGAGAATACCGC	0.507000													37	41					0	0	1	0	0
PLEKHG1	57480	broad.mit.edu	37	6	151055181	151055181	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:151055181C>G	ENST00000367328.1	+	3	676	c.364C>G	c.(364-366)Ctg>Gtg	p.L122V	PLEKHG1_ENST00000358517.2_Missense_Mutation_p.L122V	NM_001029884.1	NP_001025055.1	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 1	122	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(19)|ovary(5)|prostate(4)|stomach(1)|urinary_tract(3)	53			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		TCAGGAAATTCTGGAAACCGA	0.478000													22	86					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40408701	40408701	+	Nonsense_Mutation	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:40408701C>A	ENST00000221347.6	-	8	4145	c.4138G>T	c.(4138-4140)Gga>Tga	p.G1380*		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	1380	VWFD 3.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TAGTAGTTTCCGGGGACGGTG	0.577000													25	101					6.32553e-13	6.74601e-13	1	1	0
CHMP7	91782	broad.mit.edu	37	8	23117806	23117806	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:23117806G>C	ENST00000397677.1	+	10	1918	c.1270G>C	c.(1270-1272)Gaa>Caa	p.E424Q	CHMP7_ENST00000313219.7_Missense_Mutation_p.E424Q	NM_152272.3	NP_689485.1	Q8WUX9	CHMP7_HUMAN	charged multivesicular body protein 7	424					cellular membrane organization|late endosome to vacuole transport	cytosol|ESCRT III complex	protein transporter activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	11		Prostate(55;0.0513)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		ACTTGAAGCTGAACTTGAGAA	0.502000													36	70					0	0	1	0	0
MEGF8	1954	broad.mit.edu	37	19	42841280	42841280	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:42841280G>C	ENST00000334370.4	+	8	2070	c.1435G>C	c.(1435-1437)Gat>Cat	p.D479H	MEGF8_ENST00000251268.6_Missense_Mutation_p.D479H	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	479						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				GTGCTACGAAGATGGCATCTT	0.592000													8	17					0	0	1	0	0
ZNF800	168850	broad.mit.edu	37	7	127015006	127015006	+	Missense_Mutation	SNP	T	T	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:127015006T>G	ENST00000393313.1	-	5	975	c.384A>C	c.(382-384)gaA>gaC	p.E128D	ZNF800_ENST00000393312.1_Missense_Mutation_p.E128D|ZNF800_ENST00000265827.3_Missense_Mutation_p.E128D			Q2TB10	ZN800_HUMAN	zinc finger protein 800	128					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(8)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	32						TAATAATATATTCTCGTTTGT	0.338000													27	23					0	0	1	0	0
PCDHB16	57717	broad.mit.edu	37	5	140562940	140562940	+	Missense_Mutation	SNP	T	T	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:140562940T>C	ENST00000361016.2	+	1	1961	c.806T>C	c.(805-807)tTa>tCa	p.L269S		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		269	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCAGGGATTTAGACGGCGGA	0.478000													34	33					0	0	1	0	0
AC015849.16	0	broad.mit.edu	37	17	34234004	34234004	+	RNA	SNP	T	T	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:34234004T>A	ENST00000587132.1	-	0	4023																											CTGCTCCTGCTCACTGGGGAA	0.552000													18	21					0	0	1	0	0
LYSMD1	388695	broad.mit.edu	37	1	151134398	151134398	+	Nonsense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:151134398G>C	ENST00000368908.5	-	2	1019	c.359C>G	c.(358-360)tCa>tGa	p.S120*	LYSMD1_ENST00000440902.2_Nonsense_Mutation_p.S72*	NM_212551.4	NP_997716.1	Q96S90	LYSM1_HUMAN	LysM, putative peptidoglycan-binding, domain containing 1	120					cell wall macromolecule catabolic process					endometrium(2)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CCTCTCAGTTGAGTGTGGCCA	0.522000													39	76					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	1998950	1998950	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:1998950C>G	ENST00000262113.4	+	2	211	c.70C>G	c.(70-72)Caa>Gaa	p.Q24E	MYOM2_ENST00000523438.1_Intron	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	24					muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CCGTAATATTCAAACACGGTA	0.478000													11	31					0	0	1	0	0
CRLF1	9244	broad.mit.edu	37	19	18707475	18707475	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:18707475C>G	ENST00000392386.3	-	6	1174	c.981G>C	c.(979-981)tgG>tgC	p.W327C		NM_004750.4	NP_004741.1	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1	327	Fibronectin type-III 2.				negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)	9						TCCACTCACTCCAGATCCCGG	0.652000													6	19					0	0	1	0	0
NET1	10276	broad.mit.edu	37	10	5496393	5496393	+	Nonsense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:5496393C>T	ENST00000355029.4	+	9	1076	c.934C>T	c.(934-936)Cga>Tga	p.R312*	NET1_ENST00000542715.1_Nonsense_Mutation_p.R131*|NET1_ENST00000380359.3_Nonsense_Mutation_p.R258*|NET1_ENST00000484741.1_3'UTR	NM_001047160.2	NP_001040625.1	Q7Z628	ARHG8_HUMAN	neuroepithelial cell transforming 1	312	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell growth|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	Rho guanyl-nucleotide exchange factor activity			breast(4)|kidney(2)|large_intestine(9)|lung(5)|prostate(2)|skin(1)	23						AGATATCCCTCGAAGTCGCCT	0.433000													9	67					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16259748	16259748	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:16259748C>T	ENST00000375759.3	+	11	7217	c.7013C>T	c.(7012-7014)tCa>tTa	p.S2338L		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	2338	Interaction with MSX2 (By similarity).|RID.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		ACAACCCGATCACGCCGCAAG	0.507000													23	17					0	0	1	0	0
CNOT1	23019	broad.mit.edu	37	16	58571020	58571020	+	Nonsense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:58571020G>C	ENST00000317147.5	-	39	5851	c.5519C>G	c.(5518-5520)tCa>tGa	p.S1840*	CNOT1_ENST00000569240.1_Nonsense_Mutation_p.S1835*|CNOT1_ENST00000245138.4_Nonsense_Mutation_p.S691*	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1840					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		ATCATACTCTGAGGCTTGAGA	0.517000													15	43					0	0	1	0	0
PHF20	51230	broad.mit.edu	37	20	34458963	34458963	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr20:34458963C>T	ENST00000374012.3	+	8	1138	c.1009C>T	c.(1009-1011)Cat>Tat	p.H337Y	PHF20_ENST00000439301.1_3'UTR|PHF20_ENST00000481202.1_3'UTR			Q9BVI0	PHF20_HUMAN	PHD finger protein 20	337					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			breast(5)|endometrium(1)|kidney(7)|large_intestine(6)|lung(11)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(12;0.00631)|all_lung(11;0.0145)					TAATGGGACCCATGAGATCCT	0.438000													16	111					0	0	1	0	0
NCAPH2	29781	broad.mit.edu	37	22	50956082	50956082	+	Nonsense_Mutation	SNP	G	G	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr22:50956082G>T	ENST00000395701.3	+	4	437	c.343G>T	c.(343-345)Gag>Tag	p.E115*	NCAPH2_ENST00000395698.3_Nonsense_Mutation_p.E115*|NCAPH2_ENST00000420993.2_Nonsense_Mutation_p.E115*|NCAPH2_ENST00000299821.11_Nonsense_Mutation_p.E115*			Q6IBW4	CNDH2_HUMAN	non-SMC condensin II complex, subunit H2	115					chromosome condensation	chromosome|nucleus				breast(1)|cervix(1)|endometrium(2)|kidney(3)|lung(10)|ovary(1)|prostate(2)|skin(3)|stomach(1)	24		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.212)		CCAGGAGGCAGAGAATGAGGT	0.642000													8	31					1.12685e-05	1.16147e-05	1	1	0
PPP1R15A	23645	broad.mit.edu	37	19	49377935	49377935	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:49377935G>C	ENST00000200453.5	+	2	1714	c.1445G>C	c.(1444-1446)tGg>tCg	p.W482S		NM_014330.3	NP_055145.3	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	482	4 X 34 AA approximate repeats.|Glu-rich.|Interaction with SMAD7.				apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(8)|skin(2)|urinary_tract(1)	23		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		TTCAGGGGCTGGGGATATCGA	0.572000													17	63					0	0	1	0	0
SLC8A1	6546	broad.mit.edu	37	2	40656608	40656608	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:40656608C>G	ENST00000406785.2	-	2	1002	c.813G>C	c.(811-813)caG>caC	p.Q271H	SLC8A1_ENST00000406391.2_Missense_Mutation_p.Q271H|SLC8A1_ENST00000542024.1_Missense_Mutation_p.Q271H|SLC8A1_ENST00000405901.3_Missense_Mutation_p.Q271H|SLC8A1_ENST00000402441.1_Missense_Mutation_p.Q271H|SLC8A1_ENST00000332839.4_Missense_Mutation_p.Q271H|SLC8A1_ENST00000542756.1_Missense_Mutation_p.Q271H|SLC8A1_ENST00000403092.1_Missense_Mutation_p.Q271H|SLC8A1_ENST00000408028.2_Missense_Mutation_p.Q271H|SLC8A1_ENST00000405269.1_Missense_Mutation_p.Q271H			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1		Calmodulin-binding (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TCATCCCCCTCTGCTTGCCAG	0.423000													39	158					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40735497	40735497	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr20:40735497C>T	ENST00000373198.4	-	25	3611	c.3376G>A	c.(3376-3378)Gaa>Aaa	p.E1126K	PTPRT_ENST00000356100.2_Missense_Mutation_p.E1116K|PTPRT_ENST00000373187.1_Missense_Mutation_p.E1107K|PTPRT_ENST00000373201.1_Missense_Mutation_p.E1097K|PTPRT_ENST00000373193.3_Missense_Mutation_p.E1110K|PTPRT_ENST00000373190.1_Missense_Mutation_p.E1106K|PTPRT_ENST00000373184.1_Missense_Mutation_p.E1117K	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T		Tyrosine-protein phosphatase 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				ACCACCCCTTCATTCTCGGCC	0.567000													23	88					0	0	1	0	0
ARMC5	79798	broad.mit.edu	37	16	31476169	31476169	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:31476169C>T	ENST00000457010.2	+	4	2526	c.1825C>T	c.(1825-1827)Cgt>Tgt	p.R609C	ARMC5_ENST00000538189.1_Missense_Mutation_p.R641C|ARMC5_ENST00000563544.1_Missense_Mutation_p.R609C|ARMC5_ENST00000412665.2_Missense_Mutation_p.R253C|ARMC5_ENST00000268314.4_Missense_Mutation_p.R609C|ARMC5_ENST00000408912.3_Missense_Mutation_p.R704C	NM_024742.2	NP_079018.1	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5	609							binding			central_nervous_system(1)|endometrium(4)|large_intestine(3)|liver(2)|lung(12)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						GCCGGCACCACGTGCCCGGCC	0.706000													8	6					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10258249	10258249	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:10258249G>C	ENST00000418404.3	-	9	1027	c.864C>G	c.(862-864)ttC>ttG	p.F288L	MYH13_ENST00000252172.4_Missense_Mutation_p.F288L			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	288	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						TAATTTGGTAGAAAATATGAT	0.358000													12	12					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78570961	78570961	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:78570961C>T	ENST00000397909.2	+	27	5338	c.5165C>T	c.(5164-5166)tCc>tTc	p.S1722F	NAV3_ENST00000228327.6_Missense_Mutation_p.S1722F|NAV3_ENST00000266692.7_Missense_Mutation_p.S1545F|NAV3_ENST00000536525.2_Missense_Mutation_p.S1722F			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1722						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						AAGAAAAAGTCCACCAAGCCT	0.448000										HNSCC(70;0.22)			40	50					0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	35984703	35984703	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chrX:35984703C>G	ENST00000297866.5	+	9	1498	c.1432C>G	c.(1432-1434)Cca>Gca	p.P478A		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	478										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						TTCATTTGTTCCACATCAACT	0.308000													11	9					0	0	1	0	0
PPP1R10	5514	broad.mit.edu	37	6	30572136	30572136	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:30572136C>T	ENST00000376511.2	-	13	1807	c.1255G>A	c.(1255-1257)Gaa>Aaa	p.E419K		NM_002714.3	NP_002705.2	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	419	Essential for PPP1CA inhibition (By similarity).|Interaction with WDR82 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(1)	25						TTACCTCGTTCAGTTTCATCC	0.438000													74	81					0	0	1	0	0
KIF1B	23095	broad.mit.edu	37	1	10364665	10364665	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:10364665C>T	ENST00000377093.4	+	21	3575	c.3422C>T	c.(3421-3423)tCa>tTa	p.S1141L	KIF1B_ENST00000377083.1_Missense_Mutation_p.S1141L|KIF1B_ENST00000377081.1_Intron|KIF1B_ENST00000263934.6_Intron|KIF1B_ENST00000377086.1_Intron	NM_183416.3	NP_904325.2	O60333	KIF1B_HUMAN	kinesin family member 1B	0					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		AGACAGTTCTCAGCACCCAAT	0.473000													14	15					0	0	1	0	0
PKN2	5586	broad.mit.edu	37	1	89271669	89271669	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:89271669C>G	ENST00000370521.3	+	12	2131	c.1772C>G	c.(1771-1773)tCt>tGt	p.S591C	PKN2_ENST00000544045.1_Missense_Mutation_p.S265C|PKN2_ENST00000316005.7_3'UTR|PKN2_ENST00000370513.5_Missense_Mutation_p.S543C|PKN2_ENST00000370505.3_Missense_Mutation_p.S434C	NM_006256.2	NP_006247.1	Q16513	PKN2_HUMAN	protein kinase N2	591					signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			breast(2)|endometrium(3)|kidney(3)|large_intestine(8)|lung(15)|prostate(1)|skin(1)	33		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		GATGAATCTTCTGAATTAAGA	0.388000													19	38					0	0	1	0	0
IGKV1D-17	28900	broad.mit.edu	37	2	90121708	90121708	+	RNA	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:90121708C>T	ENST00000483379.1	+	0	232																											TGCTCTGGTTCCCAGGTAAGG	0.498000													14	78					0	0	1	0	0
ZYG11B	79699	broad.mit.edu	37	1	53255712	53255712	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:53255712G>A	ENST00000294353.6	+	6	1452	c.1307G>A	c.(1306-1308)cGg>cAg	p.R436Q	ZYG11B_ENST00000443756.2_Missense_Mutation_p.R436Q|ZYG11B_ENST00000545132.1_Missense_Mutation_p.R436Q	NM_024646.2	NP_078922.1	Q9C0D3	ZY11B_HUMAN	zyg-11 family member B, cell cycle regulator	436							protein binding			breast(1)|endometrium(1)|kidney(6)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	30						TGCAGTGACCGGATCCTTCAA	0.348000													51	62					0	0	1	0	0
C2orf53	339779	broad.mit.edu	37	2	27360907	27360907	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:27360907G>C	ENST00000335524.3	-	3	816	c.291C>G	c.(289-291)ttC>ttG	p.F97L		NM_178553.3	NP_848648.2	Q53SZ7	CB053_HUMAN	chromosome 2 open reading frame 53	97	Pro-rich.									cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTGGTGAAAGAAAGTAGGGG	0.552000													4	20					0	0	1	0	0
KIF3B	9371	broad.mit.edu	37	20	30919111	30919111	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr20:30919111G>C	ENST00000375712.3	+	9	2400	c.2233G>C	c.(2233-2235)Gtt>Ctt	p.V745L	KIF3B_ENST00000418717.2_Missense_Mutation_p.V371L	NM_004798.3	NP_004789.1	O15066	KIF3B_HUMAN	kinesin family member 3B	745	Globular.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TCGGGGGCTGGTTCCAAAGTA	0.522000													39	52					0	0	1	0	0
HMOX1	3162	broad.mit.edu	37	22	35783041	35783041	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr22:35783041C>T	ENST00000216117.8	+	3	847	c.508C>T	c.(508-510)Ccc>Tcc	p.P170S		NM_002133.2	NP_002124.1	P09601	HMOX1_HUMAN	heme oxygenase (decycling) 1	170					angiogenesis|anti-apoptosis|cell death|cellular iron ion homeostasis|endothelial cell proliferation|erythrocyte homeostasis|heme catabolic process|heme oxidation|intracellular protein kinase cascade|low-density lipoprotein particle clearance|negative regulation of leukocyte migration|negative regulation of smooth muscle cell proliferation|positive regulation of chemokine biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of smooth muscle cell proliferation|protein homooligomerization|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hydrogen peroxide|response to nicotine|smooth muscle hyperplasia|transmembrane transport|wound healing involved in inflammatory response	endoplasmic reticulum membrane|extracellular space|microsome	enzyme binding|heme binding|heme oxygenase (decyclizing) activity|protein homodimerization activity|signal transducer activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)	16					NADH(DB00157)	CTTCACCTTCCCCAACATTGC	0.602000													7	38					0	0	1	0	0
REG1P	5969	broad.mit.edu	37	2	79364427	79364427	+	RNA	SNP	A	A	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:79364427A>T	ENST00000444841.1	-	0	207																											CCTTCTGGGCAGCTGATCTGG	0.512000													11	22					0	0	1	0	0
KIAA0020	9933	broad.mit.edu	37	9	2838476	2838476	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr9:2838476C>T	ENST00000397885.2	-	2	238	c.32G>A	c.(31-33)gGa>gAa	p.G11E		NM_014878.4	NP_055693.4	Q15397	K0020_HUMAN	KIAA0020	11						endoplasmic reticulum|nucleolus	RNA binding			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)	21				GBM - Glioblastoma multiforme(50;0.0319)		TGTACTCTTTCCTGTGAATTG	0.373000													27	51					0	0	1	0	0
TNFAIP3	7128	broad.mit.edu	37	6	138196119	138196119	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:138196119G>C	ENST00000237289.4	+	3	499	c.433G>C	c.(433-435)Gag>Cag	p.E145Q		NM_001270507.1|NM_001270508.1|NM_006290.3	NP_001257436.1|NP_001257437.1|NP_006281.1	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	145	OTU.|TRAF-binding.				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(25)		breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(196)|kidney(1)|large_intestine(4)|lung(13)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	225	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		CTGGCAACTGGAGTCTCTCAA	0.493000			"""D, N, F"""		"""marginal zone B-cell lymphomas, Hodgkin's lymphoma, primary mediastinal B cell lymphoma"""								42	60					0	0	1	0	0
NKAIN4	128414	broad.mit.edu	37	20	61880215	61880215	+	Nonsense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr20:61880215C>T	ENST00000370316.3	-	3	314	c.225G>A	c.(223-225)tgG>tgA	p.W75*	NKAIN4_ENST00000370307.2_Nonsense_Mutation_p.W13*|NKAIN4_ENST00000370313.1_Nonsense_Mutation_p.W13*	NM_152864.3	NP_690603.3	Q8IVV8	NKAI4_HUMAN	Na+/K+ transporting ATPase interacting 4	75						integral to membrane|plasma membrane				endometrium(2)|lung(1)|ovary(1)	4	all_cancers(38;2.72e-09)					TGAAGACGTTCCAGGTGACCC	0.632000													7	29					0	0	1	0	0
TECPR1	25851	broad.mit.edu	37	7	97863068	97863068	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:97863068G>A	ENST00000447648.2	-	11	1636	c.1337C>T	c.(1336-1338)tCa>tTa	p.S446L	TECPR1_ENST00000542604.1_Missense_Mutation_p.S376L|TECPR1_ENST00000379795.3_Missense_Mutation_p.S446L			Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	446						integral to membrane	protein binding			central_nervous_system(2)|endometrium(8)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						CCCCAGGCCTGAGGCTGAGTT	0.652000													18	18					0	0	1	0	0
C2orf53	339779	broad.mit.edu	37	2	27360965	27360965	+	Nonsense_Mutation	SNP	G	G	C	rs144004044		TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:27360965G>C	ENST00000335524.3	-	3	758	c.233C>G	c.(232-234)tCa>tGa	p.S78*		NM_178553.3	NP_848648.2	Q53SZ7	CB053_HUMAN	chromosome 2 open reading frame 53	78	Pro-rich.									cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTCAGAATTTGAGTCACAAGA	0.562000													6	24					0	0	1	0	0
DEDD	9191	broad.mit.edu	37	1	161092290	161092290	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:161092290C>T	ENST00000392188.1	-	6	928	c.694G>A	c.(694-696)Gaa>Aaa	p.E232K	DEDD_ENST00000490843.2_Missense_Mutation_p.E202K|DEDD_ENST00000368006.3_Missense_Mutation_p.E202K|DEDD_ENST00000545495.1_Missense_Mutation_p.E202K|DEDD_ENST00000458050.2_Missense_Mutation_p.E202K|DEDD_ENST00000368005.1_Missense_Mutation_p.E232K|NIT1_ENST00000368008.1_Intron|DEDD_ENST00000489249.1_5'UTR			O75618	DEDD_HUMAN	death effector domain containing	202					apoptosis|induction of apoptosis via death domain receptors|negative regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			cervix(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(2)|skin(1)	10	all_cancers(52;3.39e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			TGGCAGTATTCAGCCCGAACC	0.488000													30	51					0	0	1	0	0
PPP2R2C	5522	broad.mit.edu	37	4	6325128	6325128	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr4:6325128G>C	ENST00000335585.5	-	9	1268	c.1245C>G	c.(1243-1245)atC>atG	p.I415M	PPP2R2C_ENST00000515571.1_Missense_Mutation_p.I398M|PPP2R2C_ENST00000506140.1_Missense_Mutation_p.I408M|PPP2R2C_ENST00000507294.1_Missense_Mutation_p.I408M|PPP2R2C_ENST00000382599.4_Missense_Mutation_p.I415M	NM_181876.2	NP_870991.1	Q9Y2T4	2ABG_HUMAN	protein phosphatase 2, regulatory subunit B, gamma	415					signal transduction	protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	28						CCGTGTGCAGGATCTTCTTGG	0.602000													18	29					0	0	1	0	0
ZNF619	285267	broad.mit.edu	37	3	40523396	40523396	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:40523396G>C	ENST00000447116.2	+	3	374	c.67G>C	c.(67-69)Gag>Cag	p.E23Q	ZNF619_ENST00000520737.1_Intron|ZNF619_ENST00000314686.5_5'UTR|ZNF619_ENST00000522736.1_5'UTR|ZNF619_ENST00000456778.1_Intron|ZNF619_ENST00000432264.2_Missense_Mutation_p.E23Q|ZNF619_ENST00000429348.2_Missense_Mutation_p.E23Q|ZNF619_ENST00000521353.1_Missense_Mutation_p.E23Q	NM_001145082.2	NP_001138554.1	E9PCD9	E9PCD9_HUMAN	zinc finger protein 619	23					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		AGTAACCTTTGAGGATGTGGC	0.507000													30	74					0	0	1	0	0
ADAM10	102	broad.mit.edu	37	15	58974397	58974397	+	Missense_Mutation	SNP	T	T	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:58974397T>C	ENST00000260408.3	-	3	766	c.323A>G	c.(322-324)tAt>tGt	p.Y108C	ADAM10_ENST00000396140.2_Intron|ADAM10_ENST00000561288.1_Intron|ADAM10_ENST00000558733.1_5'UTR|ADAM10_ENST00000402627.1_Intron	NM_001110.2	NP_001101.1	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10	108					cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			breast(1)|endometrium(1)|kidney(5)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)	27				GBM - Glioblastoma multiforme(80;0.202)		CAACTTACCATAAATATGTCC	0.303000													12	18					0	0	1	0	0
WIZ	58525	broad.mit.edu	37	19	15535458	15535458	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:15535458C>T	ENST00000389282.4	-	8	4779	c.4566G>A	c.(4564-4566)gtG>gtA	p.V1522V	WIZ_ENST00000599686.3_Silent_p.V706V|WIZ_ENST00000263381.7_Silent_p.V665V|WIZ_ENST00000545156.1_Silent_p.V836V|WIZ_ENST00000599910.2_Silent_p.V839V			O95785	WIZ_HUMAN	widely interspaced zinc finger motifs	1522						nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	24						CCTCAGCCTTCACGGTGCCTG	0.726000													9	6					0	0	1	0	0
SLC20A1	6574	broad.mit.edu	37	2	113414753	113414753	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:113414753G>A	ENST00000272542.3	+	6	1252	c.713G>A	c.(712-714)tGt>tAt	p.C238Y	SLC20A1_ENST00000480984.1_3'UTR	NM_005415.4	NP_005406.3	Q8WUM9	S20A1_HUMAN	solute carrier family 20 (phosphate transporter), member 1	238					phosphate metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to plasma membrane	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(8)|ovary(3)|skin(1)|urinary_tract(3)	28						TCGGTGGGATGTGCAGTTTTC	0.443000													40	44					0	0	1	0	0
DOCK6	57572	broad.mit.edu	37	19	11348927	11348927	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:11348927G>A	ENST00000294618.7	-	15	1708	c.1697C>T	c.(1696-1698)tCc>tTc	p.S566F	C19orf80_ENST00000591200.1_Intron	NM_020812.3	NP_065863.2	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	566	DHR-1.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(8)|liver(2)|lung(9)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	39						GTTGCGCACGGAGCCCTGGCG	0.667000													11	18					0	0	1	0	0
MLEC	9761	broad.mit.edu	37	12	121132723	121132723	+	Missense_Mutation	SNP	A	A	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:121132723A>G	ENST00000228506.3	+	3	939	c.511A>G	c.(511-513)Atg>Gtg	p.M171V	MLEC_ENST00000412616.2_Intron	NM_014730.2	NP_055545.1	Q14165	MLEC_HUMAN	malectin	171					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	carbohydrate binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)	16						AATTATACCTATGAGCATCAG	0.473000													6	90					0	0	1	0	0
PROSER1	80209	broad.mit.edu	37	13	39585517	39585517	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr13:39585517C>G	ENST00000352251.3	-	13	3653	c.2820G>C	c.(2818-2820)caG>caC	p.Q940H	PROSER1_ENST00000350125.3_Missense_Mutation_p.Q918H|PROSER1_ENST00000484434.3_5'UTR	NM_025138.4	NP_079414.3	Q86XN7	CM023_HUMAN	proline and serine rich 1	940																	GCCACCCACTCTGGGACAGGC	0.468000													21	60					0	0	1	0	0
ZNF93	81931	broad.mit.edu	37	19	20044542	20044542	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:20044542G>A	ENST00000343769.5	+	4	806	c.778G>A	c.(778-780)Gaa>Aaa	p.E260K	AC007204.2_ENST00000592245.1_lincRNA	NM_031218.3	NP_112495.2	P35789	ZNF93_HUMAN	zinc finger protein 93	260						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(6)|kidney(2)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	24						CTACAAGTGTGAAGAATGTGG	0.373000													24	48					0	0	1	0	0
PROSC	11212	broad.mit.edu	37	8	37630357	37630357	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:37630357C>G	ENST00000328195.3	+	5	471	c.404C>G	c.(403-405)tCt>tGt	p.S135C		NM_007198.3	NP_009129.1	O94903	PROSC_HUMAN	proline synthetase co-transcribed homolog (bacterial)	135							pyridoxal phosphate binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|prostate(1)	7		Lung NSC(58;0.174)	BRCA - Breast invasive adenocarcinoma(5;6.14e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)		L-Proline(DB00172)|Pyridoxal Phosphate(DB00114)	AGAAAAGGTTCTCCTGAAAGG	0.433000													23	66					0	0	1	0	0
GNMT	27232	broad.mit.edu	37	6	42930943	42930943	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:42930943C>G	ENST00000372808.3	+	4	595	c.585C>G	c.(583-585)atC>atG	p.I195M		NM_018960.4	NP_061833.1	Q14749	GNMT_HUMAN	glycine N-methyltransferase	195					protein homotetramerization|protein modification process|S-adenosylmethionine metabolic process		folic acid binding|glycine binding|glycine N-methyltransferase activity			kidney(2)|large_intestine(1)|lung(1)	4	Colorectal(47;0.196)		all cancers(41;0.00196)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0461)		Glycine(DB00145)|S-Adenosylmethionine(DB00118)	GGAAGAACATCTACTATAAGG	0.622000													11	14					0	0	1	0	0
ZNF112	7665	broad.mit.edu	37	19	44831938	44831938	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:44831938C>G	ENST00000354340.4	-	4	2423	c.2372G>C	c.(2371-2373)aGg>aCg	p.R791T	ZNF112_ENST00000337401.4_Missense_Mutation_p.R797T|ZNF112_ENST00000536500.1_Missense_Mutation_p.R814T	NM_013380.3	NP_037512.3			zinc finger protein 112																		CACATGAACCCTTTGGTGTGC	0.483000													57	97					0	0	1	0	0
CCM2	83605	broad.mit.edu	37	7	45078011	45078011	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:45078011G>C	ENST00000381112.3	+	2	932	c.253G>C	c.(253-255)Gag>Cag	p.E85Q	CCM2_ENST00000461377.1_3'UTR|CCM2_ENST00000544363.1_Missense_Mutation_p.E64Q|CCM2_ENST00000541586.1_Intron|CCM2_ENST00000258781.6_Missense_Mutation_p.E64Q|CCM2_ENST00000474617.1_Missense_Mutation_p.E58Q|CCM2_ENST00000475551.1_Missense_Mutation_p.E58Q	NM_001029835.2	NP_001025006.1	Q9BSQ5	CCM2_HUMAN	cerebral cavernous malformation 2	64	PID.				endothelial tube morphogenesis|integrin-mediated signaling pathway|stress-activated MAPK cascade|vasculogenesis	cytoplasm	protein binding			NS(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19						CGACTATATTGAGAAGGAGGT	0.532000													38	44					0	0	1	0	0
SLC25A13	10165	broad.mit.edu	37	7	95750650	95750650	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:95750650G>C	ENST00000416240.2	-	18	2074	c.1884C>G	c.(1882-1884)atC>atG	p.I628M	SLC25A13_ENST00000494085.1_5'UTR|SLC25A13_ENST00000542654.1_Missense_Mutation_p.I519M|SLC25A13_ENST00000265631.5_Missense_Mutation_p.I627M	NM_001160210.1|NM_014251.2	NP_001153682.1|NP_055066.1	Q9UJS0	CMC2_HUMAN	solute carrier family 25 (aspartate/glutamate carrier), member 13	627					ATP biosynthetic process|gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to plasma membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity			breast(4)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|prostate(1)|skin(4)	42	all_cancers(62;7.75e-08)|all_epithelial(64;1.16e-07)		STAD - Stomach adenocarcinoma(171;0.194)		L-Aspartic Acid(DB00128)	CAGGCAGGTTGATCCTGGATT	0.408000													21	42					0	0	1	0	0
FAM184A	79632	broad.mit.edu	37	6	119345335	119345335	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:119345335C>G	ENST00000338891.7	-	2	1246	c.803G>C	c.(802-804)aGg>aCg	p.R268T	FAM184A_ENST00000522284.1_Missense_Mutation_p.R148T|FAM184A_ENST00000352896.5_Missense_Mutation_p.R148T|FAM184A_ENST00000368475.4_Missense_Mutation_p.R148T|RP11-351A11.1_ENST00000518570.1_RNA|FAM184A_ENST00000521531.1_Missense_Mutation_p.R268T	NM_024581.4	NP_078857.5	Q8NB25	F184A_HUMAN	family with sequence similarity 184, member A	268										breast(2)|central_nervous_system(2)|endometrium(2)|kidney(5)|large_intestine(19)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(5)	52						AAGCTGTGACCTTTTCAAAGT	0.383000													18	72					0	0	1	0	0
SYNGR2	9144	broad.mit.edu	37	17	76167919	76167919	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:76167919G>A	ENST00000225777.3	+	4	636	c.577G>A	c.(577-579)Gcc>Acc	p.A193T	SYNGR2_ENST00000585591.1_Missense_Mutation_p.A193T|SYNGR2_ENST00000588282.1_Silent_p.T222T|SYNGR2_ENST00000589711.1_3'UTR|SYNGR2_ENST00000590201.1_Missense_Mutation_p.A137T|SYNGR2_ENST00000592456.1_3'UTR			O43760	SNG2_HUMAN	synaptogyrin 2	193						integral to plasma membrane				endometrium(2)|large_intestine(1)|liver(1)|lung(1)|skin(1)|urinary_tract(1)	7			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.0994)			CACTGCCTACGCCTCCTACCC	0.627000													25	43					0	0	1	0	0
OR10Z1	128368	broad.mit.edu	37	1	158576655	158576655	+	Nonsense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:158576655C>T	ENST00000361284.1	+	1	427	c.427C>T	c.(427-429)Cag>Tag	p.Q143*		NM_001004478.1	NP_001004478.1	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z, member 1	143					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(6)|lung(21)|pancreas(1)|prostate(3)|skin(4)	37	all_hematologic(112;0.0378)					CCTCTGTGCCCAGCTGGTCAT	0.498000													31	41					0	0	1	0	0
CNOT1	23019	broad.mit.edu	37	16	58571854	58571854	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:58571854G>C	ENST00000317147.5	-	38	5687	c.5355C>G	c.(5353-5355)ttC>ttG	p.F1785L	CNOT1_ENST00000569240.1_Missense_Mutation_p.F1780L|CNOT1_ENST00000245138.4_Missense_Mutation_p.F636L	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1785					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		CAATGGTGTGGAACAGATCTG	0.443000													16	13					0	0	1	0	0
FLVCR1	28982	broad.mit.edu	37	1	213032309	213032309	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:213032309G>A	ENST00000366971.4	+	1	713	c.515G>A	c.(514-516)gGc>gAc	p.G172D		NM_014053.3	NP_054772.1	Q9Y5Y0	FLVC1_HUMAN	feline leukemia virus subgroup C cellular receptor 1	172					cell death|cellular iron ion homeostasis|heme export|transmembrane transport	integral to plasma membrane	heme transporter activity|protein binding|receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(2)	12				OV - Ovarian serous cystadenocarcinoma(81;0.00733)|all cancers(67;0.013)|GBM - Glioblastoma multiforme(131;0.0845)|Epithelial(68;0.11)		GACACCAGAGGCCTGCGGCTC	0.632000													27	21					0	0	1	0	0
NAP1L3	4675	broad.mit.edu	37	X	92927448	92927448	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chrX:92927448C>T	ENST00000373079.3	-	1	1119	c.856G>A	c.(856-858)Gag>Aag	p.E286K	NAP1L3_ENST00000475430.2_Missense_Mutation_p.E279K	NM_004538.5	NP_004529.2	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	286					nucleosome assembly	chromatin assembly complex				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	34						AGCCTTTCCTCAGGAACTCTT	0.438000													31	7					0	0	1	0	0
IGFL4	444882	broad.mit.edu	37	19	46543577	46543577	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:46543577C>G	ENST00000377697.1	-	3	221	c.168G>C	c.(166-168)ttG>ttC	p.L56F	IGFL4_ENST00000601672.1_5'UTR	NM_001002923.1	NP_001002923.1	Q6B9Z1	IGFL4_HUMAN	IGF-like family member 4	56						extracellular region				cervix(1)|kidney(1)|lung(1)	3		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.0036)|GBM - Glioblastoma multiforme(486;0.022)|Epithelial(262;0.208)		GGGTCTGGTTCAAGTCTAGGA	0.597000													17	23					0	0	1	0	0
PHF12	57649	broad.mit.edu	37	17	27244422	27244422	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:27244422C>G	ENST00000577226.1	-	7	1361	c.1015G>C	c.(1015-1017)Gat>Cat	p.D339H	PHF12_ENST00000582655.1_5'UTR|PHF12_ENST00000332830.4_Missense_Mutation_p.D339H|PHF12_ENST00000268756.3_Missense_Mutation_p.D339H			Q96QT6	PHF12_HUMAN	PHD finger protein 12	339	Interaction with SIN3A.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding	p.D339N(1)		breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			TGGAAACGATCAAACACCTGG	0.532000													40	43					0	0	1	0	0
KIF1B	23095	broad.mit.edu	37	1	10364096	10364096	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:10364096C>G	ENST00000377093.4	+	21	3006	c.2853C>G	c.(2851-2853)atC>atG	p.I951M	KIF1B_ENST00000377083.1_Missense_Mutation_p.I951M|KIF1B_ENST00000377081.1_Intron|KIF1B_ENST00000263934.6_Intron|KIF1B_ENST00000377086.1_Intron	NM_183416.3	NP_904325.2	O60333	KIF1B_HUMAN	kinesin family member 1B	0					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding	p.I951I(1)		breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		ATAGGTTCATCCCTCCTGAGA	0.488000													39	34					0	0	1	0	0
ROPN1	54763	broad.mit.edu	37	3	123688013	123688013	+	Nonsense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:123688013G>A	ENST00000184183.4	-	7	968	c.628C>T	c.(628-630)Cag>Tag	p.Q210*	ROPN1_ENST00000405845.3_Nonsense_Mutation_p.Q210*	NM_017578.2	NP_060048.2	Q9HAT0	ROP1A_HUMAN	rhophilin associated tail protein 1	210	Interaction with RHPN1 (By similarity).				signal transduction		cAMP-dependent protein kinase regulator activity			lung(2)|ovary(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.148)		TACTCCAGCTGAACCCTGGGG	0.368000													60	74					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140481940	140481940	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:140481940C>T	ENST00000231130.2	+	1	1707	c.1707C>T	c.(1705-1707)tcC>tcT	p.S569S		NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		569	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGAACGGCTCCGCGCCCTGCA	0.711000													29	36					0	0	1	0	0
TJP2	9414	broad.mit.edu	37	9	71842743	71842743	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr9:71842743G>C	ENST00000377245.4	+	8	1481	c.1273G>C	c.(1273-1275)Gat>Cat	p.D425H	TJP2_ENST00000348208.4_Missense_Mutation_p.D425H|TJP2_ENST00000539225.1_Missense_Mutation_p.D456H|TJP2_ENST00000535702.1_Missense_Mutation_p.D429H|TJP2_ENST00000265384.7_Missense_Mutation_p.D425H|TJP2_ENST00000453658.2_Missense_Mutation_p.D402H	NM_004817.3	NP_004808.2	Q9UDY2	ZO2_HUMAN	tight junction protein 2	425					cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(5)|lung(9)|prostate(3)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	35						TCAGTATTCTGATTATGATTA	0.323000													14	16					0	0	1	0	0
TRIM15	89870	broad.mit.edu	37	6	30138762	30138762	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:30138762C>T	ENST00000376694.4	+	6	1326	c.857C>T	c.(856-858)gCg>gTg	p.A286V	TRIM15_ENST00000376688.1_Intron	NM_033229.2	NP_150232.2	Q9C019	TRI15_HUMAN	tripartite motif containing 15	286	B30.2/SPRY.				mesodermal cell fate determination	intracellular	zinc ion binding			large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(1)	14						GAAAACTTGGCGCATCATCTG	0.428000													16	126					0	0	1	0	0
TRPC4AP	26133	broad.mit.edu	37	20	33609026	33609026	+	Silent	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr20:33609026G>C	ENST00000252015.2	-	9	1274	c.1185C>G	c.(1183-1185)ctC>ctG	p.L395L	TRPC4AP_ENST00000539834.1_Intron|TRPC4AP_ENST00000432634.2_Silent_p.L356L|TRPC4AP_ENST00000451813.2_Silent_p.L387L			Q8TEL6	TP4AP_HUMAN	transient receptor potential cation channel, subfamily C, member 4 associated protein	395	Interaction with TNFRSF1A (By similarity).				protein ubiquitination|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	protein binding			breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|skin(1)|stomach(1)|urinary_tract(1)	32			BRCA - Breast invasive adenocarcinoma(18;0.00936)			GCAGCACGCAGAGGACATAGA	0.587000													5	42					0	0	1	0	0
INPPL1	3636	broad.mit.edu	37	11	71946948	71946948	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:71946948G>C	ENST00000298229.2	+	25	3001	c.2797G>C	c.(2797-2799)Gaa>Caa	p.E933Q	INPPL1_ENST00000538751.1_Missense_Mutation_p.E691Q|INPPL1_ENST00000541756.1_Missense_Mutation_p.E691Q	NM_001567.3	NP_001558.3	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	933					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						CAGGTTATTTGAAGAACCAGA	0.642000													21	25					0	0	1	0	0
NCOR1	9611	broad.mit.edu	37	17	15965075	15965075	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:15965075C>G	ENST00000268712.3	-	37	5778	c.5521G>C	c.(5521-5523)Gag>Cag	p.E1841Q	NCOR1_ENST00000395857.3_Missense_Mutation_p.E425Q|NCOR1_ENST00000395851.1_Missense_Mutation_p.E1857Q	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	1841	Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		TGCTTACTCTCTTTTGTTTTG	0.527000													30	29					0	0	1	0	0
ASPM	259266	broad.mit.edu	37	1	197073959	197073959	+	Nonsense_Mutation	SNP	C	C	T	rs147622433		TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:197073959C>T	ENST00000367409.4	-	18	4678	c.4422G>A	c.(4420-4422)tgG>tgA	p.W1474*	ASPM_ENST00000367408.1_Intron|ASPM_ENST00000294732.7_Intron	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	1474					mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						GCATTCTATACCATGATTGTA	0.289000													68	50					0	0	1	0	0
VWA8	23078	broad.mit.edu	37	13	42442531	42442531	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr13:42442531G>A	ENST00000379310.3	-	10	1231	c.1163C>T	c.(1162-1164)tCc>tTc	p.S388F	VWA8_ENST00000281496.6_Missense_Mutation_p.S388F	NM_015058.1	NP_055873.1			von Willebrand factor A domain containing 8																		AGAAGCTTGGGACACATGGTT	0.368000													22	47					0	0	1	0	0
MECP2	4204	broad.mit.edu	37	X	153297731	153297731	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chrX:153297731C>T	ENST00000303391.6	-	3	553	c.304G>A	c.(304-306)Gaa>Aaa	p.E102K	MECP2_ENST00000407218.1_Missense_Mutation_p.E102K|MECP2_ENST00000453960.2_Missense_Mutation_p.E114K	NM_004992.3	NP_004983.1	P51608	MECP2_HUMAN	methyl CpG binding protein 2 (Rett syndrome)	102	MBD.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	heterochromatin|nucleus	double-stranded methylated DNA binding|protein domain specific binding|protein N-terminus binding|transcription corepressor activity			breast(2)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(8)|prostate(2)|urinary_tract(1)	23	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GTCCAGCCTTCAGGCAGGGTG	0.562000													77	31					0	0	1	0	0
IGHV1OR21-1	390530	broad.mit.edu	37	21	10862636	10862636	+	RNA	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr21:10862636G>C	ENST00000559480.1	+	0	15																				breast(1)|endometrium(1)|kidney(3)|lung(20)|urinary_tract(1)	26						ACTGGAATTGGAGGATCCTGT	0.498000													51	240					0	0	1	0	0
GRK5	2869	broad.mit.edu	37	10	121189893	121189893	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:121189893G>A	ENST00000392870.2	+	7	869	c.540G>A	c.(538-540)ccG>ccA	p.P180P	GRK5_ENST00000369108.3_Silent_p.P75P	NM_005308.2	NP_005299.1	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	180	N-terminal.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			endometrium(2)|large_intestine(5)|lung(15)|skin(3)|stomach(1)|urinary_tract(1)	27		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		CCAGGCAACCGGTGACCAAAA	0.483000													8	53					0	0	1	0	0
GDF6	392255	broad.mit.edu	37	8	97156941	97156941	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:97156941C>T	ENST00000287020.5	-	2	1317	c.1218G>A	c.(1216-1218)ctG>ctA	p.L406L		NM_001001557.2	NP_001001557.1	Q6KF10	GDF6_HUMAN	growth differentiation factor 6	406					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27	Breast(36;2.67e-05)					TGGAGTTCATCAGCGTCTGGA	0.617000													7	74					0	0	1	0	0
ITGA2	3673	broad.mit.edu	37	5	52382783	52382783	+	Splice_Site	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:52382783C>T	ENST00000296585.5	+	28	3403	c.3260C>T	c.(3259-3261)tCa>tTa	p.S1087L		NM_002203.3	NP_002194.2	P17301	ITA2_HUMAN	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	1087					axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(1)|lung(18)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	47		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				ATGTTCCAGTCAACGTTCCAG	0.393000													6	34					0	0	1	0	0
CCDC135	84229	broad.mit.edu	37	16	57741527	57741527	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:57741527C>G	ENST00000360716.3	+	8	1235	c.1014C>G	c.(1012-1014)atC>atG	p.I338M	CCDC135_ENST00000336825.8_Missense_Mutation_p.I273M|CCDC135_ENST00000394337.4_Missense_Mutation_p.I338M			Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	338						cytoplasm				breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						TCCTGGGCATCGAAAGCCTGT	0.567000													6	14					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84700134	84700134	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:84700134C>T	ENST00000286744.5	+	28	4928	c.4704C>T	c.(4702-4704)caC>caT	p.H1568H	ADAMTSL3_ENST00000567476.1_Silent_p.H1568H	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	1568						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			AGCAGCGTCACACAGCTTGTC	0.537000													39	109					0	0	1	0	0
RGS22	26166	broad.mit.edu	37	8	101020780	101020780	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:101020780G>A	ENST00000360863.6	-	15	2378	c.2184C>T	c.(2182-2184)taC>taT	p.Y728Y	RGS22_ENST00000523287.1_Silent_p.Y547Y|RGS22_ENST00000523437.1_Silent_p.Y716Y	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	728					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			AAGGAGCAACGTATGTGGCAA	0.393000													101	24					0	0	1	0	0
BEND3	57673	broad.mit.edu	37	6	107391272	107391272	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:107391272C>G	ENST00000429433.2	-	5	1772	c.1123G>C	c.(1123-1125)Gag>Cag	p.E375Q	BEND3_ENST00000369042.1_Missense_Mutation_p.E375Q	NM_001080450.2	NP_001073919.1	Q5T5X7	BEND3_HUMAN	BEN domain containing 3	375										central_nervous_system(1)|cervix(2)|endometrium(3)|large_intestine(7)|lung(10)|ovary(4)|prostate(3)	30						AGGGCCTCCTCCTGGTCTTTG	0.637000													17	55					0	0	1	0	0
HTR7	3363	broad.mit.edu	37	10	92617005	92617005	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:92617005C>T	ENST00000371721.3	-	1	666	c.424G>A	c.(424-426)Gac>Aac	p.D142N	HTR7_ENST00000371719.2_Missense_Mutation_p.D142N|HTR7_ENST00000277874.6_Missense_Mutation_p.D142N|HTR7_ENST00000336152.3_Missense_Mutation_p.D142N			P34969	5HT7R_HUMAN	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	142					blood circulation|circadian rhythm	integral to plasma membrane	protein binding|serotonin receptor activity	p.D142N(1)		NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30					Eletriptan(DB00216)|Methysergide(DB00247)|Ziprasidone(DB00246)	CCGATGAGGTCGGTGACGCTG	0.597000													6	18					0	0	1	0	0
MVB12B	89853	broad.mit.edu	37	9	129154364	129154364	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr9:129154364G>C	ENST00000361171.3	+	5	510	c.429G>C	c.(427-429)aaG>aaC	p.K143N	MVB12B_ENST00000535766.1_Missense_Mutation_p.K136N|MVB12B_ENST00000545391.1_Missense_Mutation_p.K143N|MVB12B_ENST00000436593.3_Missense_Mutation_p.K128N	NM_033446.2	NP_258257.1			multivesicular body subunit 12B																		CTTTTAGGAAGAAGAGGCTGT	0.468000													82	59					0	0	1	0	0
ZNF304	57343	broad.mit.edu	37	19	57869066	57869066	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:57869066C>G	ENST00000391705.3	+	4	2113	c.1829C>G	c.(1828-1830)aCt>aGt	p.T610S	ZNF304_ENST00000598744.1_Missense_Mutation_p.T568S|ZNF304_ENST00000282286.5_Missense_Mutation_p.T610S|ZNF304_ENST00000443917.2_Missense_Mutation_p.T657S	NM_020657.2	NP_065708.2	Q9HCX3	ZN304_HUMAN	zinc finger protein 304	610					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)	26		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		AGGGTTCACACTGGAGAAAAG	0.488000													24	50					0	0	1	0	0
GRIK3	2899	broad.mit.edu	37	1	37337853	37337853	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:37337853C>T	ENST00000373091.3	-	4	684	c.668G>A	c.(667-669)cGa>cAa	p.R223Q	GRIK3_ENST00000373093.4_Missense_Mutation_p.R223Q	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	223					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	TTCCCGGCCTCGCTTCATCTC	0.592000													11	43					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	988877	988877	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:988877C>G	ENST00000315939.6	+	11	3155	c.2512C>G	c.(2512-2514)Cag>Gag	p.Q838E	WNK1_ENST00000535572.1_Intron|WNK1_ENST00000530271.2_Missense_Mutation_p.Q1336E|WNK1_ENST00000537687.1_Intron|WNK1_ENST00000340908.4_Missense_Mutation_p.Q431E	NM_018979.3	NP_061852.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	838					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CTTGCTCCCTCAGTACCCTGT	0.537000													15	85					0	0	1	0	0
VCPIP1	80124	broad.mit.edu	37	8	67578333	67578333	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:67578333C>T	ENST00000310421.4	-	1	1119	c.861G>A	c.(859-861)ctG>ctA	p.L287L		NM_025054.4	NP_079330.2	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex interacting protein 1	287	OTU.				protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity			breast(7)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(6)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)			GGATATTCCTCAGGCCCAAGG	0.463000													9	125					0	0	1	0	0
UBL4A	8266	broad.mit.edu	37	X	153714226	153714226	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chrX:153714226C>T	ENST00000369660.4	-	3	332	c.247G>A	c.(247-249)Gag>Aag	p.E83K	UBL4A_ENST00000369653.4_Missense_Mutation_p.E83K|UBL4A_ENST00000477777.1_5'UTR	NM_014235.3	NP_055050.1	P11441	UBL4A_HUMAN	ubiquitin-like 4A	83					protein modification process|tail-anchored membrane protein insertion into ER membrane|transport	BAT3 complex	small conjugating protein ligase activity			endometrium(5)|lung(1)|urinary_tract(1)	7	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTCTGGGCCTCGCCTTCTTCT	0.597000													83	34					0	0	1	0	0
CCDC18	343099	broad.mit.edu	37	1	93720145	93720145	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:93720145C>G	ENST00000343253.7	+	24	3815	c.3313C>G	c.(3313-3315)Caa>Gaa	p.Q1105E	CCDC18_ENST00000334652.5_3'UTR|CCDC18_ENST00000557479.1_Missense_Mutation_p.Q1224E|CCDC18_ENST00000401026.3_Missense_Mutation_p.Q1106E|CCDC18_ENST00000338949.4_3'UTR			Q5T9S5	CCD18_HUMAN	coiled-coil domain containing 18	1105										breast(5)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	42		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		TGAAAGAACACAACAAAGGAT	0.313000													28	97					0	0	1	0	0
KIF3B	9371	broad.mit.edu	37	20	30915413	30915413	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr20:30915413G>C	ENST00000375712.3	+	7	2084	c.1917G>C	c.(1915-1917)ttG>ttC	p.L639F	KIF3B_ENST00000418717.2_Missense_Mutation_p.L265F	NM_004798.3	NP_004789.1	O15066	KIF3B_HUMAN	kinesin family member 3B	639	Globular.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			AGAGACCATTGAGCCAGCACG	0.502000													18	79					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75055630	75055630	+	Nonsense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:75055630G>A	ENST00000326665.5	-	12	2079	c.1861C>T	c.(1861-1863)Cag>Tag	p.Q621*	RP4-612J11.1_ENST00000416017.1_RNA|C1orf173_ENST00000420661.2_Nonsense_Mutation_p.Q424*	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	621	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						CTCAGTTCCTGAGAAGATGAC	0.433000													34	46					0	0	1	0	0
HMBOX1	79618	broad.mit.edu	37	8	28827984	28827984	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:28827984G>A	ENST00000397358.3	+	4	1152	c.448G>A	c.(448-450)Gaa>Aaa	p.E150K	HMBOX1_ENST00000558662.1_Missense_Mutation_p.E150K|HMBOX1_ENST00000523613.1_Missense_Mutation_p.E150K|HMBOX1_ENST00000355231.5_Missense_Mutation_p.E150K|HMBOX1_ENST00000519047.1_Missense_Mutation_p.E150K|HMBOX1_ENST00000287701.10_Missense_Mutation_p.E150K|HMBOX1_ENST00000403668.2_Missense_Mutation_p.E150K|HMBOX1_ENST00000524238.1_Missense_Mutation_p.E150K|HMBOX1_ENST00000444075.1_Missense_Mutation_p.E150K	NM_024567.3	NP_078843.2	Q6NT76	HMBX1_HUMAN	homeobox containing 1	150					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)	11		Ovarian(32;0.0192)		KIRC - Kidney renal clear cell carcinoma(542;0.135)|Kidney(114;0.161)		ATACAGTTTTGAAGCCTCAGA	0.398000													13	31					0	0	1	0	0
CPA6	57094	broad.mit.edu	37	8	68346349	68346349	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:68346349G>A	ENST00000297770.4	-	9	1180	c.965C>T	c.(964-966)tCc>tTc	p.S322F	CPA6_ENST00000297769.4_Intron	NM_020361.4	NP_065094.3	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6	322					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(5)	26			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			TGCATGAAAGGAGAGATAAGC	0.413000													90	39					0	0	1	0	0
MAN1B1	11253	broad.mit.edu	37	9	139995590	139995590	+	Silent	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr9:139995590C>G	ENST00000371589.4	+	7	1123	c.1050C>G	c.(1048-1050)ctC>ctG	p.L350L	MAN1B1_ENST00000474902.1_Silent_p.L53L	NM_016219.4	NP_057303.2	Q9UKM7	MA1B1_HUMAN	mannosidase, alpha, class 1B, member 1	350					oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|endoplasmic reticulum quality control compartment|integral to membrane	alpha-mannosidase activity|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			autonomic_ganglia(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(2)	14	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;3.08e-05)|Epithelial(140;0.000513)		GGGACAGCCTCTTCCTGAGGA	0.552000													48	18					0	0	1	0	0
RBMXL1	494115	broad.mit.edu	37	1	89448906	89448906	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:89448906G>C	ENST00000399794.2	-	3	1319	c.604C>G	c.(604-606)Cgt>Ggt	p.R202G	CCBL2_ENST00000370491.3_Intron|CCBL2_ENST00000260508.4_Intron|RBMXL1_ENST00000321792.5_Missense_Mutation_p.R202G|CCBL2_ENST00000446900.2_Intron|CCBL2_ENST00000370485.2_Intron	NM_001162536.2	NP_001156008.1	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	202							nucleotide binding|RNA binding										ACATCTCTACGAGAGGGGAGC	0.473000													29	111					0	0	1	0	0
RANGAP1	5905	broad.mit.edu	37	22	41657564	41657564	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr22:41657564G>A	ENST00000455915.2	-	5	1970	c.501C>T	c.(499-501)acC>acT	p.T167T	RANGAP1_ENST00000356244.3_Silent_p.T167T|RANGAP1_ENST00000405486.1_Silent_p.T167T|RANGAP1_ENST00000407260.4_Intron			P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	167					mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GGTGACATTCGGTCAGAGCTG	0.622000													7	27					0	0	1	0	0
DDB2	1643	broad.mit.edu	37	11	47260364	47260364	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:47260364C>T	ENST00000256996.4	+	10	1443	c.1248C>T	c.(1246-1248)ctC>ctT	p.L416L	DDB2_ENST00000378603.3_Silent_p.L352L|DDB2_ENST00000378601.3_3'UTR|DDB2_ENST00000378600.3_Silent_p.L227L	NM_000107.2	NP_000098.1	Q92466	DDB2_HUMAN	damage-specific DNA binding protein 2, 48kDa	416					nucleotide-excision repair, DNA damage removal|protein autoubiquitination|protein polyubiquitination|response to UV	nucleoplasm|protein complex	damaged DNA binding|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(1)	17						ACCACATTCTCATCTGGAGCC	0.527000			"""Mis, N"""			"""skin basal cell, skin squamous cell, melanoma"""		Direct reversal of damage;Nucleotide excision repair (NER)	Xeroderma Pigmentosum				4	33					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140262067	140262067	+	Missense_Mutation	SNP	G	G	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:140262067G>T	ENST00000289272.2	+	1	214	c.214G>T	c.(214-216)Ggg>Tgg	p.G72W	PCDHA13_ENST00000409494.1_Missense_Mutation_p.G72W|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA8_ENST00000531613.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAAAAGACACGGGGACCTTCT	0.617000													31	78					5.45727e-16	5.87951e-16	1	1	0
ALMS1	7840	broad.mit.edu	37	2	73799944	73799944	+	Nonsense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:73799944C>G	ENST00000264448.6	+	16	11048	c.10937C>G	c.(10936-10938)tCa>tGa	p.S3646*	ALMS1_ENST00000409009.1_Nonsense_Mutation_p.S3604*	NM_015120.4	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3646					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						CTCCAGGTCTCAGAAAGTACA	0.443000													37	63					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125022909	125022909	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:125022909C>T	ENST00000522917.1	+	14	1982	c.1776C>T	c.(1774-1776)ttC>ttT	p.F592F	FER1L6-AS1_ENST00000518567.1_RNA|FER1L6_ENST00000399018.1_Silent_p.F592F	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	592						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			ACCAGACCTTCAGGCTGCACT	0.483000													26	97					0	0	1	0	0
TSSK2	23617	broad.mit.edu	37	22	19119600	19119600	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr22:19119600G>A	ENST00000399635.2	+	1	1280	c.688G>A	c.(688-690)Gag>Aag	p.E230K	DGCR14_ENST00000252137.6_3'UTR	NM_053006.4	NP_443732.3	Q96PF2	TSSK2_HUMAN	testis-specific serine kinase 2	230	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(2)|lung(2)|prostate(4)|stomach(1)	11	Colorectal(54;0.0993)					TATCCAGAAGGAGCACCGTGT	0.592000													20	53					0	0	1	0	0
HHIPL2	79802	broad.mit.edu	37	1	222717307	222717307	+	Silent	SNP	A	A	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:222717307A>G	ENST00000343410.6	-	2	604	c.546T>C	c.(544-546)ccT>ccC	p.P182P		NM_024746.3	NP_079022.2	Q6UWX4	HIPL2_HUMAN	HHIP-like 2	182					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(7)|lung(28)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59				GBM - Glioblastoma multiforme(131;0.0185)		TCAGGACATTAGGGAAGCAAT	0.617000													6	25					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10468766	10468766	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:10468766G>C	ENST00000382483.3	-	4	3065	c.2842C>G	c.(2842-2844)Ctg>Gtg	p.L948V		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	948					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GAGCGGGGCAGAGAGCTGGGT	0.642000													22	40					0	0	1	0	0
SEC61A2	55176	broad.mit.edu	37	10	12199922	12199922	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:12199922C>G	ENST00000379033.3	+	8	874	c.727C>G	c.(727-729)Ctg>Gtg	p.L243V	SEC61A2_ENST00000298428.9_Missense_Mutation_p.L265V|SEC61A2_ENST00000379020.4_Intron|SEC61A2_ENST00000304267.8_Missense_Mutation_p.L265V|SEC61A2_ENST00000495368.1_3'UTR	NM_001142628.1	NP_001136100.1	Q9H9S3	S61A2_HUMAN	Sec61 alpha 2 subunit (S. cerevisiae)	265						endoplasmic reticulum membrane|integral to membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		Renal(717;0.228)				TCGCGTTGATCTGCCCATTAA	0.502000													42	35					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247587253	247587253	+	Nonsense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:247587253C>T	ENST00000366497.2	+	4	1288	c.508C>T	c.(508-510)Cga>Tga	p.R170*	NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000391828.3_Nonsense_Mutation_p.R170*|NLRP3_ENST00000391827.2_Nonsense_Mutation_p.R170*|NLRP3_ENST00000336119.3_Nonsense_Mutation_p.R170*|NLRP3_ENST00000348069.2_Nonsense_Mutation_p.R170*|NLRP3_ENST00000366496.2_Nonsense_Mutation_p.R170*	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	170					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			ACGCTACACACGACTGCGTCT	0.557000													10	7					0	0	1	0	0
FOXR1	283150	broad.mit.edu	37	11	118850379	118850379	+	Splice_Site	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:118850379G>A	ENST00000317011.3	+	4	836		c.e4+1			NM_181721.2	NP_859072.1	Q6PIV2	FOXR1_HUMAN	forkhead box R1						embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		GTTTCACTCGGTATGTGCCGG	0.612000													13	45					0	0	1	0	0
NANOS3	342977	broad.mit.edu	37	19	13988525	13988525	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:13988525G>A	ENST00000397555.2	+	2	406	c.406G>A	c.(406-408)Gac>Aac	p.D136N	NANOS3_ENST00000339133.5_Missense_Mutation_p.D155N|NANOS3_ENST00000591727.1_Intron	NM_001098622.2	NP_001092092.1	P60323	NANO3_HUMAN	nanos homolog 3 (Drosophila)	136					anti-apoptosis|germ cell development|multicellular organismal development|oogenesis|regulation of cell cycle|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|nucleus|stress granule	RNA binding|zinc ion binding			breast(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	7			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			GGTCCGGCCTGACAAGGCGAA	0.662000													6	9					0	0	1	0	0
CD93	22918	broad.mit.edu	37	20	23066321	23066321	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr20:23066321G>A	ENST00000246006.4	-	1	656	c.509C>T	c.(508-510)tCc>tTc	p.S170F		NM_012072.3	NP_036204.2	Q9NPY3	C1QR1_HUMAN	CD93 molecule	170	C-type lectin.				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					ACTTCCGGGGGAGCCTGGGCT	0.647000													9	29					0	0	1	0	0
TM9SF4	9777	broad.mit.edu	37	20	30729449	30729449	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr20:30729449G>A	ENST00000217315.5	+	4	668	c.328G>A	c.(328-330)Gaa>Aaa	p.E110K	TM9SF4_ENST00000398022.2_Missense_Mutation_p.E127K			Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	127						integral to membrane				central_nervous_system(2)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GCGGATCACAGAAGACTACTA	0.592000													19	112					0	0	1	0	0
SFTPA1	653509	broad.mit.edu	37	10	81373761	81373761	+	Silent	SNP	A	A	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:81373761A>T	ENST00000398636.3	+	6	777	c.639A>T	c.(637-639)cgA>cgT	p.R213R	SFTPA1_ENST00000372313.5_Silent_p.R154R|SFTPA1_ENST00000372308.3_Silent_p.R213R|SFTPA1_ENST00000428376.2_Silent_p.R213R|SFTPA1_ENST00000419470.2_Silent_p.R228R	NM_001164644.1|NM_001164646.1|NM_005411.4	NP_001158116.1|NP_001158118.1|NP_005402.3	Q8IWL2	SFTA1_HUMAN	surfactant protein A1	213	C-type lectin.				cell junction assembly|respiratory gaseous exchange	collagen|extracellular space	lipid transporter activity|sugar binding			endometrium(1)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			ACTGGTACCGAGGGGAGCCCG	0.562000													23	106					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105414540	105414540	+	Silent	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr14:105414540G>C	ENST00000333244.5	-	7	7367	c.7248C>G	c.(7246-7248)ctC>ctG	p.L2416L	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2416						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGGGGCCCTTGAGATCTACTT	0.627000													76	82					0	0	1	0	0
ZNF646	9726	broad.mit.edu	37	16	31089780	31089780	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:31089780C>T	ENST00000394979.2	+	1	2558	c.2135C>T	c.(2134-2136)tCa>tTa	p.S712L	ZNF646_ENST00000300850.5_Missense_Mutation_p.S712L			O15015	ZN646_HUMAN	zinc finger protein 646	712					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(1)|lung(21)|ovary(1)|prostate(4)|skin(3)	49						CAAGACCCTTCAGGGGAAAGT	0.587000													13	31					0	0	1	0	0
ADAM12	8038	broad.mit.edu	37	10	127738007	127738007	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:127738007C>T	ENST00000368679.4	-	16	2050	c.1741G>A	c.(1741-1743)Gga>Aga	p.G581R	ADAM12_ENST00000368676.4_Missense_Mutation_p.G581R	NM_003474.4	NP_003465.3	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12	581	Cys-rich.				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			biliary_tract(1)|breast(7)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		TGGATTTTTCCACATTTAGCA	0.483000													15	58					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57588463	57588463	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:57588463C>T	ENST00000243077.3	+	50	8638	c.8172C>T	c.(8170-8172)ggC>ggT	p.G2724G		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	2724	LDL-receptor class A 15.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GTGAACATGGCGAGGACGAGA	0.592000													24	22					0	0	1	0	0
HSP90B1	7184	broad.mit.edu	37	12	104333386	104333386	+	Missense_Mutation	SNP	T	T	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:104333386T>C	ENST00000299767.5	+	8	1257	c.1075T>C	c.(1075-1077)Tac>Cac	p.Y359H		NM_003299.2	NP_003290.1	P14625	ENPL_HUMAN	heat shock protein 90kDa beta (Grp94), member 1	359					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(4)	29					Rifabutin(DB00615)	CAAAGCTTTCTACAAATCATT	0.308000													7	58					0	0	1	0	0
CHD7	55636	broad.mit.edu	37	8	61655654	61655654	+	Nonsense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:61655654C>T	ENST00000423902.2	+	2	2142	c.1663C>T	c.(1663-1665)Cag>Tag	p.Q555*	CHD7_ENST00000525508.1_Nonsense_Mutation_p.Q555*|CHD7_ENST00000524602.1_Nonsense_Mutation_p.Q555*	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	555	Pro-rich.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GCCTGTGCATCAGGTAAGGGG	0.502000													10	9					0	0	1	0	0
DGKB	1607	broad.mit.edu	37	7	14722443	14722443	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:14722443G>A	ENST00000403951.2	-	11	1272	c.853C>T	c.(853-855)Cgc>Tgc	p.R285C	DGKB_ENST00000258767.5_Missense_Mutation_p.R285C|DGKB_ENST00000399322.3_Missense_Mutation_p.R285C|DGKB_ENST00000407950.1_Missense_Mutation_p.R278C|DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000402815.1_Missense_Mutation_p.R285C|DGKB_ENST00000406247.3_Missense_Mutation_p.R285C|DGKB_ENST00000444700.2_Missense_Mutation_p.R278C			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	285					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	GCCACACAGCGCTCATGGACT	0.438000													3	12					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3149776	3149776	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr4:3149776G>A	ENST00000355072.5	+	26	3485	c.3340G>A	c.(3340-3342)Gaa>Aaa	p.E1114K		NM_002111.6	NP_002102	P42858	HD_HUMAN	huntingtin	1114					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		CTCTGAAGAAGAAGCCAACCC	0.572000													5	31					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20541128	20541128	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr4:20541128C>G	ENST00000504154.1	+	19	2149	c.1897C>G	c.(1897-1899)Cgt>Ggt	p.R633G	SLIT2_ENST00000503837.1_Missense_Mutation_p.R629G|SLIT2_ENST00000503823.1_Missense_Mutation_p.R625G|SLIT2_ENST00000273739.5_Missense_Mutation_p.R637G	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	633					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding	p.R633C(1)		NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						CAGTTCTGTGCGTTTGCTTTC	0.388000													5	124					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47407066	47407066	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:47407066C>T	ENST00000310638.4	-	1	71	c.40G>A	c.(40-42)Gat>Aat	p.D14N	CYP4A11_ENST00000371905.1_Missense_Mutation_p.D14N|CYP4A11_ENST00000457840.2_5'UTR|CYP4A11_ENST00000462347.1_Missense_Mutation_p.D14N|CYP4A11_ENST00000371904.4_Missense_Mutation_p.D14N	NM_000778.3	NP_000769.2	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	14					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	CCAGAGACATCACCCAGGAGT	0.597000													36	43					0	0	1	0	0
ZNF257	113835	broad.mit.edu	37	19	22255685	22255685	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:22255685G>A	ENST00000594947.1	+	2	222	c.78G>A	c.(76-78)caG>caA	p.Q26Q	ZNF257_ENST00000600162.1_Silent_p.Q26Q	NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	26	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				CTGCACAGCAGAATTTATATA	0.428000													53	98					0	0	1	0	0
DNAJC6	9829	broad.mit.edu	37	1	65849979	65849979	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:65849979C>A	ENST00000395325.3	+	6	756	c.599C>A	c.(598-600)cCa>cAa	p.P200Q	DNAJC6_ENST00000498720.1_3'UTR|DNAJC6_ENST00000371069.4_Missense_Mutation_p.P257Q|DNAJC6_ENST00000263441.7_Missense_Mutation_p.P187Q	NM_014787.3	NP_055602.1	O75061	AUXI_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 6	200	Phosphatase tensin-type.				cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(22)|ovary(1)|prostate(2)|skin(1)	39						GCAAAGCGACCAGGAATTGGA	0.448000													4	32					0.00909568	0.00914525	1	1	0
CPT1B	1375	broad.mit.edu	37	22	51010513	51010513	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr22:51010513C>T	ENST00000360719.2	-	13	1634	c.1497G>A	c.(1495-1497)acG>acA	p.T499T	CPT1B_ENST00000312108.7_Silent_p.T499T|CPT1B_ENST00000434492.2_Silent_p.T296T|CPT1B_ENST00000457250.1_Silent_p.T465T|CPT1B_ENST00000405237.3_Silent_p.T499T|CHKB-CPT1B_ENST00000453634.1_3'UTR|CPT1B_ENST00000395650.2_Silent_p.T499T|CPT1B_ENST00000440709.1_Silent_p.T418T	NM_001145135.1|NM_152245.2	NP_001138607.1|NP_689451.1	Q92523	CPT1B_HUMAN	carnitine palmitoyltransferase 1B (muscle)	499					carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;3.56e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.39e-74)|Epithelial(4;5.58e-70)|GBM - Glioblastoma multiforme(4;5.59e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.207)		GCCCGGTCTCCGTGTAGCCCA	0.622000													8	22					0	0	1	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24874510	24874510	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:24874510C>T	ENST00000396432.2	-	26	5194	c.4708G>A	c.(4708-4710)Gaa>Aaa	p.E1570K		NM_020824.3	NP_065875.3	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1569					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						TGTTTCGTTTCTGGACTGGTT	0.512000													33	43					0	0	1	0	0
DDX20	11218	broad.mit.edu	37	1	112309421	112309421	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:112309421C>T	ENST00000475700.1	+	3	3557	c.1199C>T	c.(1198-1200)tCt>tTt	p.S400F	DDX20_ENST00000369702.4_Missense_Mutation_p.S792F			Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	792	Helicase C-terminal.				assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			endometrium(3)|kidney(7)|large_intestine(6)|lung(3)|pancreas(1)|prostate(1)	21		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCTGCCGCTTCTCATTCATAT	0.398000													38	50					0	0	1	0	0
CNTD1	124817	broad.mit.edu	37	17	40958808	40958808	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:40958808G>A	ENST00000588408.1	+	5	973	c.697G>A	c.(697-699)Gag>Aag	p.E233K	CNTD1_ENST00000588527.1_Missense_Mutation_p.E150K|CNTD1_ENST00000315066.5_3'UTR	NM_173478.2	NP_775749.2	Q8N815	CNTD1_HUMAN	cyclin N-terminal domain containing 1	233										central_nervous_system(2)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	10		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		GGCTTCAATTGAGAACTCCAC	0.532000													12	28					0	0	1	0	0
PPM1K	152926	broad.mit.edu	37	4	89199466	89199466	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr4:89199466G>A	ENST00000608933.1	-	2	659	c.270C>T	c.(268-270)atC>atT	p.I90I	PPM1K_ENST00000514204.1_Silent_p.I90I|PPM1K_ENST00000506423.1_5'UTR|PPM1K_ENST00000295908.7_Silent_p.I90I|PPM1K_ENST00000508256.1_Intron|PPM1K_ENST00000315194.4_Silent_p.I90I	NM_152542.4	NP_689755.3	Q8N3J5	PPM1K_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1K						protein dephosphorylation	mitochondrial matrix|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(1)	13		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000192)		TTTCCAAGCTGATTTTGGGAA	0.488000													25	23					0	0	1	0	0
TCEB3C	162699	broad.mit.edu	37	18	44555257	44555257	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr18:44555257C>T	ENST00000330682.2	-	1	1192	c.957G>A	c.(955-957)aaG>aaA	p.K319K	KATNAL2_ENST00000592005.1_Intron|KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron	NM_145653.3	NP_663628.2	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide 3C (elongin A3)	319	Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(16)|skin(2)	30						ACACCGGCATCTTAGCGTTCA	0.657000													11	490					0	0	1	0	0
CEP170	9859	broad.mit.edu	37	1	243327864	243327864	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:243327864G>C	ENST00000366542.1	-	13	3449	c.3398C>G	c.(3397-3399)tCt>tGt	p.S1133C	CEP170_ENST00000366544.1_Missense_Mutation_p.S1035C|CEP170_ENST00000366543.1_Missense_Mutation_p.S1035C	NM_014812.2	NP_055627.2	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa	1133	Targeting to centrosomes.|Targeting to microtubules.					centriole|microtubule|spindle				NS(1)|breast(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	62	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			TTTTGATGTAGAACTTGTTGT	0.483000													24	18					0	0	1	0	0
GAS2L2	246176	broad.mit.edu	37	17	34073364	34073364	+	Silent	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:34073364G>C	ENST00000254466.6	-	6	1179	c.1152C>G	c.(1150-1152)ccC>ccG	p.P384P	GAS2L2_ENST00000587565.1_Silent_p.P368P	NM_139285.3	NP_644814.1	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	384					cell cycle arrest	cytoplasm|cytoskeleton				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		ATGAGGACTGGGGGCTGGGTG	0.592000													53	57					0	0	1	0	0
PPP1R3C	5507	broad.mit.edu	37	10	93390552	93390552	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:93390552C>T	ENST00000238994.5	-	2	170	c.86G>A	c.(85-87)tGc>tAc	p.C29Y		NM_005398.5	NP_005389.1	Q9UQK1	PPR3C_HUMAN	protein phosphatase 1, regulatory subunit 3C	29							protein serine/threonine phosphatase activity			breast(1)|endometrium(1)|large_intestine(5)|lung(4)|upper_aerodigestive_tract(1)	12		Colorectal(252;0.235)				ATGTGCCAAGCAAAGCCTCAT	0.453000													27	60					0	0	1	0	0
SEC61A2	55176	broad.mit.edu	37	10	12199024	12199024	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:12199024C>T	ENST00000379033.3	+	7	816	c.669C>T	c.(667-669)ctC>ctT	p.L223L	SEC61A2_ENST00000298428.9_Silent_p.L245L|SEC61A2_ENST00000379020.4_Silent_p.L245L|SEC61A2_ENST00000304267.8_Silent_p.L245L|SEC61A2_ENST00000495368.1_3'UTR	NM_001142628.1	NP_001136100.1	Q9H9S3	S61A2_HUMAN	Sec61 alpha 2 subunit (S. cerevisiae)	245						endoplasmic reticulum membrane|integral to membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		Renal(717;0.228)				TCATGAACCTCATTGCTACAG	0.393000													35	32					0	0	1	0	0
SEMA7A	8482	broad.mit.edu	37	15	74708969	74708969	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:74708969C>T	ENST00000261918.4	-	7	1296	c.748G>A	c.(748-750)Gac>Aac	p.D250N	SEMA7A_ENST00000543145.2_Missense_Mutation_p.D236N|SEMA7A_ENST00000542748.1_Missense_Mutation_p.D85N	NM_003612.3	NP_003603.1	O75326	SEM7A_HUMAN	semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)	250	Sema.				axon guidance|immune response|inflammatory response|integrin-mediated signaling pathway|positive regulation of axon extension|positive regulation of ERK1 and ERK2 cascade|positive regulation of macrophage cytokine production|regulation of inflammatory response	anchored to membrane|external side of plasma membrane	receptor activity			breast(3)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(3)|lung(12)|upper_aerodigestive_tract(1)	30						GGATTCTTGTCAGGATTGTCC	0.547000													15	20					0	0	1	0	0
FAM13A	10144	broad.mit.edu	37	4	89726162	89726162	+	Splice_Site	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr4:89726162C>T	ENST00000264344.5	-	8	1256	c.1049G>A	c.(1048-1050)aGt>aAt	p.S350N	FAM13A_ENST00000395002.2_Splice_Site_p.S24N|FAM13A_ENST00000503556.1_Intron|FAM13A_ENST00000502459.1_5'UTR|FAM13A_ENST00000508369.1_Splice_Site_p.S24N|FAM13A_ENST00000511976.1_Intron|FAM13A_ENST00000513837.1_Intron	NM_014883.3	NP_055698.2	O94988	FA13A_HUMAN	family with sequence similarity 13, member A	350					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	55						AAATAAATACCTCAAATAGAA	0.299000													6	33					0	0	1	0	0
HMHA1	23526	broad.mit.edu	37	19	1073672	1073672	+	Splice_Site	SNP	G	G	T	rs112940068		TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:1073672G>T	ENST00000313093.2	+	5	881		c.e5-1		HMHA1_ENST00000590214.1_Splice_Site|HMHA1_ENST00000586866.1_Splice_Site|HMHA1_ENST00000543365.1_Splice_Site|HMHA1_ENST00000536472.1_Splice_Site|HMHA1_ENST00000539243.2_Splice_Site	NM_012292.3	NP_036424.2	Q92619	HMHA1_HUMAN	histocompatibility (minor) HA-1						regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(7)|ovary(1)|prostate(2)	16		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGCCCTGCAGAGTGTCCGAG	0.672000													3	18					0.00909568	0.00914525	1	1	0
WWP1	11059	broad.mit.edu	37	8	87414422	87414422	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:87414422C>T	ENST00000517970.1	+	8	1021	c.714C>T	c.(712-714)gcC>gcT	p.A238A	WWP1_ENST00000265428.4_Silent_p.A238A|WWP1_ENST00000341922.2_Intron|WWP1_ENST00000349423.2_Intron	NM_007013.3	NP_008944.1	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase 1	238					central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(9)|liver(4)|lung(10)|prostate(2)|urinary_tract(1)	31						CTGAGCCTGCCGATGACACTG	0.438000													15	18					0	0	1	0	0
FOXE1	2304	broad.mit.edu	37	9	100616622	100616622	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr9:100616622C>A	ENST00000375123.3	+	1	1087	c.426C>A	c.(424-426)ttC>ttA	p.F142L		NM_004473.3	NP_004464.2	O00358	FOXE1_HUMAN	forkhead box E1 (thyroid transcription factor 2)	142					cell migration|embryonic organ morphogenesis|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|peripheral nervous system development|pharynx development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thymus development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(1)|endometrium(1)|lung(2)|upper_aerodigestive_tract(1)	5		Acute lymphoblastic leukemia(62;0.158)				GCGGCAGCTTCCTGCGCCGCC	0.716000													9	13					5.4927e-09	5.80747e-09	1	1	0
SLIT1	6585	broad.mit.edu	37	10	98819900	98819900	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:98819900G>A	ENST00000266058.4	-	10	1202	c.957C>T	c.(955-957)aaC>aaT	p.N319N	ARHGAP19-SLIT1_ENST00000453547.2_3'UTR|SLIT1_ENST00000371041.3_Silent_p.N319N|SLIT1_ENST00000371070.4_Silent_p.N319N	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	319					axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		ACTTGATGCCGTTCAGCTCCA	0.612000													14	25					0	0	1	0	0
GCC2	9648	broad.mit.edu	37	2	109092074	109092074	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:109092074G>C	ENST00000309863.6	+	8	3658	c.2944G>C	c.(2944-2946)Gat>Cat	p.D982H		NM_181453.3	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain containing 2	982					Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			breast(8)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	54						GAAAGAACTAGATTCCAGCAG	0.279000													6	10					0	0	1	0	0
PYGB	5834	broad.mit.edu	37	20	25261745	25261745	+	Nonsense_Mutation	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr20:25261745C>A	ENST00000216962.4	+	11	1510	c.1400C>A	c.(1399-1401)tCg>tAg	p.S467*		NM_002862.3	NP_002853.2	P11216	PYGB_HUMAN	phosphorylase, glycogen; brain	467					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	31					Pyridoxal Phosphate(DB00114)	GTGAAACAGTCGGTGTGAGTG	0.597000													19	62					4.63292e-17	5.01334e-17	1	1	0
HNRNPAB	3182	broad.mit.edu	37	5	177634141	177634141	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:177634141G>A	ENST00000358344.3	+	5	841	c.584G>A	c.(583-585)cGa>cAa	p.R195Q	HNRNPAB_ENST00000355836.5_Missense_Mutation_p.R195Q|HNRNPAB_ENST00000515193.1_Missense_Mutation_p.R195Q|HNRNPAB_ENST00000514633.1_Missense_Mutation_p.R195Q|HNRNPAB_ENST00000506339.1_Missense_Mutation_p.R195Q|HNRNPAB_ENST00000504898.1_Missense_Mutation_p.R195Q|HNRNPAB_ENST00000506259.1_Missense_Mutation_p.R195Q	NM_031266.2	NP_112556.2	Q99729	ROAA_HUMAN	heterogeneous nuclear ribonucleoprotein A/B	195	RRM 2.				epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding			large_intestine(4)|prostate(1)|urinary_tract(1)	6						AACAAAAGACGAGGTTTTGTG	0.438000													44	29					0	0	1	0	0
ZNF830	91603	broad.mit.edu	37	17	33288933	33288933	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:33288933G>A	ENST00000361952.3	+	1	385	c.348G>A	c.(346-348)gcG>gcA	p.A116A		NM_052857.3	NP_443089.3	Q96NB3	ZN830_HUMAN	zinc finger protein 830	116					cell division|mitosis	cytoplasm|nucleus	metal ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(1)|liver(2)|lung(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		Ovarian(249;0.17)				TCAAGAGAGCGAAGGCCACCT	0.567000													100	58					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56404972	56404972	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:56404972C>T	ENST00000355701.3	-	1	1180	c.310G>A	c.(310-312)Gag>Aag	p.E104K	BZRAP1_ENST00000343736.4_Missense_Mutation_p.E104K|BZRAP1-AS1_ENST00000579527.1_RNA|BZRAP1_ENST00000268893.6_Missense_Mutation_p.E104K	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	104						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TCCACTTCCTCATCCTCTGGC	0.642000													39	36					0	0	1	0	0
HIVEP2	3097	broad.mit.edu	37	6	143093540	143093540	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:143093540G>A	ENST00000367603.2	-	5	3078	c.2336C>T	c.(2335-2337)tCa>tTa	p.S779L	HIVEP2_ENST00000367604.1_Missense_Mutation_p.S779L|HIVEP2_ENST00000012134.2_Missense_Mutation_p.S779L	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	779					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		ATCAATGGCTGAAGGTGACTC	0.517000													7	34					0	0	1	0	0
GLIS2	84662	broad.mit.edu	37	16	4385105	4385105	+	Silent	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:4385105C>G	ENST00000262366.3	+	6	1388	c.567C>G	c.(565-567)gtC>gtG	p.V189V	PAM16_ENST00000577031.1_Intron|GLIS2_ENST00000433375.1_Silent_p.V189V			Q9BZE0	GLIS2_HUMAN	GLIS family zinc finger 2	189					cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development	cytoplasm|nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|transcription regulatory region DNA binding|zinc ion binding			breast(1)|cervix(4)|endometrium(1)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	11						TGGACCATGTCAACGATTACC	0.617000													17	13					0	0	1	0	0
TAF1C	9013	broad.mit.edu	37	16	84212582	84212582	+	Nonsense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:84212582G>A	ENST00000567759.1	-	14	2757	c.2575C>T	c.(2575-2577)Cag>Tag	p.Q859*	TAF1C_ENST00000341690.6_Nonsense_Mutation_p.Q765*|TAF1C_ENST00000541676.1_Nonsense_Mutation_p.Q766*|TAF1C_ENST00000378541.4_Nonsense_Mutation_p.Q859*|TAF1C_ENST00000566732.1_Nonsense_Mutation_p.Q833*|TAF1C_ENST00000570117.1_Nonsense_Mutation_p.Q527*	NM_005679.3	NP_005670	Q15572	TAF1C_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa	859					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding			endometrium(1)|kidney(3)|large_intestine(3)|lung(11)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	26						CGGAGGGGCTGAGAGCTAGAG	0.657000													16	13					0	0	1	0	0
PA2G4	5036	broad.mit.edu	37	12	56501350	56501350	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:56501350C>T	ENST00000303305.6	+	5	858	c.439C>T	c.(439-441)Cac>Tac	p.H147Y	PA2G4_ENST00000552766.1_Missense_Mutation_p.H147Y|RP11-603J24.9_ENST00000548861.1_Missense_Mutation_p.H128Y|RP11-603J24.17_ENST00000548595.1_RNA	NM_006191.2	NP_006182.2	Q9UQ80	PA2G4_HUMAN	proliferation-associated 2G4, 38kDa	147					cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(1)|urinary_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			TAAGGCAGCTCACCTTTGTGC	0.453000													18	55					0	0	1	0	0
KRTAP4-8	728224	broad.mit.edu	37	17	39254054	39254054	+	Missense_Mutation	SNP	A	A	T	rs76270529	by1000genomes	TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:39254054A>T	ENST00000333822.4	-	1	339	c.283T>A	c.(283-285)Tgc>Agc	p.C95S		NM_031960.2	NP_114166.1	Q9BYQ9	KRA48_HUMAN	keratin associated protein 4-8	95	25 X 5 AA repeats of C-C-[IKRQVHEC]- [SPRT]-[STCVQPR].					keratin filament		p.C95S(4)		endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|prostate(1)	11						ctggagatgcagcagcTAGGG	0.677000													4	24					0	0	1	0	0
CBLL1	79872	broad.mit.edu	37	7	107393922	107393922	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:107393922G>A	ENST00000440859.3	+	3	715	c.248G>A	c.(247-249)cGa>cAa	p.R83Q	CBLL1_ENST00000415884.2_Missense_Mutation_p.R83Q|CBLL1_ENST00000222597.2_Missense_Mutation_p.R82Q	NM_001284291.1|NM_024814.2	NP_001271220.1|NP_079090.2	Q75N03	HAKAI_HUMAN	Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase						cell-cell adhesion|negative regulation of cell adhesion|positive regulation of cell migration|positive regulation of endocytosis		protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(3)	21						GCAAATCAGCGAAGATTTCCT	0.294000													27	41					0	0	1	0	0
SPAST	6683	broad.mit.edu	37	2	32339880	32339880	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:32339880C>T	ENST00000315285.3	+	5	981	c.856C>T	c.(856-858)Cct>Tct	p.P286S	SPAST_ENST00000345662.1_Missense_Mutation_p.P254S	NM_014946.3	NP_055761.2	Q9UBP0	SPAST_HUMAN	spastin	286	Required for interaction with RTN1.|Required for interaction with microtubules and microtubule severing.|Sufficient for interaction with microtubules.|Sufficient for microtubule severing.				cell cycle|cell death|cell differentiation|cytokinesis, completion of separation|ER to Golgi vesicle-mediated transport|microtubule bundle formation|microtubule severing|nervous system development|protein hexamerization|protein homooligomerization	endoplasmic reticulum|endosome|integral to membrane|microtubule|microtubule organizing center|nucleus|perinuclear region of cytoplasm|spindle	alpha-tubulin binding|ATP binding|beta-tubulin binding|microtubule binding|microtubule-severing ATPase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(8)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TGGTCCTGCTCCTACCACTCA	0.398000													28	39					0	0	1	0	0
LOC150776	150776	broad.mit.edu	37	2	132258950	132258950	+	RNA	SNP	A	A	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:132258950A>G	ENST00000438378.2	+	0	900					NR_026922.1																						GTGTCCCTCCACGTCCGTACT	0.592000													13	7					0	0	1	0	0
RXFP1	59350	broad.mit.edu	37	4	159569649	159569649	+	Splice_Site	SNP	A	A	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr4:159569649A>G	ENST00000307765.5	+	17	2007		c.e17-1		RXFP1_ENST00000470033.1_Splice_Site|RXFP1_ENST00000460056.2_Splice_Site|RXFP1_ENST00000448688.2_Splice_Site|RXFP1_ENST00000343542.5_Splice_Site	NM_001253727.1|NM_001253728.1|NM_001253730.1|NM_001253732.1|NM_001253733.1|NM_021634.3	NP_001240656.1|NP_001240657.1|NP_001240659.1|NP_001240661.1|NP_001240662.1|NP_067647.2	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1							integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|liver(2)|lung(22)|prostate(1)|skin(10)	49	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		TATTCCAAATAGGTATTAATT	0.264000													9	29					0	0	1	0	0
LRRC49	54839	broad.mit.edu	37	15	71341889	71341889	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:71341889G>C	ENST00000260382.5	+	16	2259	c.1999G>C	c.(1999-2001)Gaa>Caa	p.E667Q	LRRC49_ENST00000560691.1_Missense_Mutation_p.E373Q|LRRC49_ENST00000560369.1_Missense_Mutation_p.E672Q|LRRC49_ENST00000560158.2_Missense_Mutation_p.E355Q|LRRC49_ENST00000443425.2_Missense_Mutation_p.E623Q|LRRC49_ENST00000436542.2_3'UTR|LRRC49_ENST00000544974.2_Missense_Mutation_p.E657Q	NM_001199017.1|NM_017691.3	NP_001185946.1|NP_060161.2	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	667						cytoplasm|microtubule				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|lung(14)|ovary(2)|prostate(3)|skin(3)	34						TGCAGTCATAGAAATTCGCAA	0.378000													25	50					0	0	1	0	0
ZFP57	346171	broad.mit.edu	37	6	29643821	29643821	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:29643821C>G	ENST00000376883.1	-	4	490	c.79G>C	c.(79-81)Gag>Cag	p.E27Q	ZFP57_ENST00000488757.1_Missense_Mutation_p.E47Q|ZFP57_ENST00000376881.3_Missense_Mutation_p.E27Q			Q9NU63	ZFP57_HUMAN	ZFP57 zinc finger protein	19	KRAB.				DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(16)|ovary(4)|skin(4)|urinary_tract(5)	44						GCCACATCCTCAAAGGTGACT	0.433000													54	150					0	0	1	0	0
NPDC1	56654	broad.mit.edu	37	9	139935328	139935328	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr9:139935328G>A	ENST00000371600.3	-	3	1400	c.728C>T	c.(727-729)tCc>tTc	p.S243F	NPDC1_ENST00000371601.4_Missense_Mutation_p.S165F|NPDC1_ENST00000488145.1_5'UTR			Q9NQX5	NPDC1_HUMAN	neural proliferation, differentiation and control, 1	165						integral to membrane				NS(1)|large_intestine(1)|lung(1)|prostate(1)|urinary_tract(1)	5	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		CACCGGGTCGGATGACACAGG	0.741000													4	4					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35670235	35670235	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:35670235C>T	ENST00000440995.2	+	10	1430	c.1430C>T	c.(1429-1431)tCt>tTt	p.S477F	SPEF2_ENST00000282469.6_Missense_Mutation_p.S477F|SPEF2_ENST00000356031.3_Missense_Mutation_p.S477F|SPEF2_ENST00000509059.1_Missense_Mutation_p.S477F			Q9C093	SPEF2_HUMAN	sperm flagellar 2	477					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GAACAAGCCTCTGTTAAGACA	0.368000													19	90					0	0	1	0	0
INPPL1	3636	broad.mit.edu	37	11	71946465	71946465	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:71946465G>C	ENST00000298229.2	+	23	2833	c.2629G>C	c.(2629-2631)Gag>Cag	p.E877Q	INPPL1_ENST00000538751.1_Missense_Mutation_p.E635Q|INPPL1_ENST00000541756.1_Missense_Mutation_p.E635Q	NM_001567.3	NP_001558.3	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	877					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						GGTGCCCACGGAGCGCCTGGG	0.632000													48	55					0	0	1	0	0
CNNM2	54805	broad.mit.edu	37	10	104687126	104687126	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:104687126C>T	ENST00000369875.3	+	2	1810	c.1646C>T	c.(1645-1647)tCa>tTa	p.S549L	CNNM2_ENST00000433628.2_Intron|CNNM2_ENST00000369878.4_Intron	NM_199077.2	NP_951059.1	Q9H8M5	CNNM2_HUMAN	cyclin M2	0	CBS 2.				ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|urinary_tract(1)	19		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		AAACCCAAATCATACCAACAC	0.353000													54	83					0	0	1	0	0
CCDC109B	55013	broad.mit.edu	37	4	110605751	110605751	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr4:110605751C>G	ENST00000394650.4	+	6	898	c.765C>G	c.(763-765)atC>atG	p.I255M		NM_017918.4	NP_060388.2	Q9NWR8	C109B_HUMAN	coiled-coil domain containing 109B	255			I -> V (in dbSNP:rs1053680).			integral to membrane				breast(1)|endometrium(1)|kidney(4)|large_intestine(2)|lung(1)	9				OV - Ovarian serous cystadenocarcinoma(123;6.65e-06)		CATACTTCATCACATTTGCAA	0.453000													16	81					0	0	1	0	0
EMILIN2	84034	broad.mit.edu	37	18	2892247	2892247	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr18:2892247C>A	ENST00000254528.3	+	4	2281	c.2122C>A	c.(2122-2124)Cat>Aat	p.H708N		NM_032048.2	NP_114437.2	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2	708					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(4)	48				READ - Rectum adenocarcinoma(2;0.1)		CAGGGTGTCTCATATGGAGAA	0.547000													13	68					5.50884e-06	5.70199e-06	1	1	0
LRP1B	53353	broad.mit.edu	37	2	141215130	141215130	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:141215130C>G	ENST00000389484.3	-	61	10687	c.9716G>C	c.(9715-9717)cGt>cCt	p.R3239P		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3239					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTTATGGGCACGGCTGAGTGA	0.438000										TSP Lung(27;0.18)			16	53					0	0	1	0	0
SLC25A20	788	broad.mit.edu	37	3	48895187	48895187	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:48895187C>G	ENST00000319017.4	-	9	1060	c.862G>C	c.(862-864)Gaa>Caa	p.E288Q	SLC25A20_ENST00000430379.1_Missense_Mutation_p.E215Q|SLC25A20_ENST00000544097.1_Missense_Mutation_p.E238Q	NM_000387.5	NP_000378.1	O43772	MCAT_HUMAN	solute carrier family 25 (carnitine/acylcarnitine translocase), member 20	288					carnitine shuttle|cellular lipid metabolic process|regulation of fatty acid oxidation	integral to membrane|mitochondrial inner membrane	acyl carnitine transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(5)|prostate(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.000168)|Kidney(197;0.00231)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	L-Carnitine(DB00583)	ATGGCAACTTCAAAGCCAAGG	0.478000													8	17					0	0	1	0	0
FAM49B	51571	broad.mit.edu	37	8	130864509	130864509	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:130864509C>T	ENST00000519824.2	-	8	805	c.532G>A	c.(532-534)Gaa>Aaa	p.E178K	FAM49B_ENST00000523509.1_Missense_Mutation_p.E178K|FAM49B_ENST00000522250.1_Missense_Mutation_p.E32K|FAM49B_ENST00000401979.2_Missense_Mutation_p.E178K|FAM49B_ENST00000522746.1_Missense_Mutation_p.E178K|FAM49B_ENST00000519540.1_Missense_Mutation_p.E178K|FAM49B_ENST00000517654.1_Missense_Mutation_p.E178K|FAM49B_ENST00000522941.1_Missense_Mutation_p.E32K|FAM49B_ENST00000519110.1_Missense_Mutation_p.E178K	NM_016623.4	NP_057707.3	Q9NUQ9	FA49B_HUMAN	family with sequence similarity 49, member B	178										kidney(1)|large_intestine(6)|lung(4)|prostate(1)	12	Ovarian(5;0.000567)|Esophageal squamous(12;0.00693)|Acute lymphoblastic leukemia(118;0.155)		LUAD - Lung adenocarcinoma(14;0.0989)			TTATTTACTTCATTTTCTCCT	0.378000													6	24					0	0	1	0	0
QARS	5859	broad.mit.edu	37	3	49139107	49139107	+	Silent	SNP	G	G	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:49139107G>T	ENST00000306125.6	-	9	1072	c.735C>A	c.(733-735)gtC>gtA	p.V245V	QARS_ENST00000414533.1_Silent_p.V234V|QARS_ENST00000420147.2_Intron|QARS_ENST00000470225.1_Intron			P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	245					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			breast(1)|endometrium(1)|large_intestine(9)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	TGTGTGGAGTGACCACATAGC	0.552000													11	44					2.27111e-07	2.37742e-07	1	1	0
ALPK2	115701	broad.mit.edu	37	18	56149148	56149148	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr18:56149148C>A	ENST00000361673.3	-	13	6633	c.6420G>T	c.(6418-6420)caG>caT	p.Q2140H		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	2140							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TCGGCTGCTTCTGTTTCTGGT	0.433000													21	38					2.37509e-13	2.54032e-13	1	1	0
PSME4	23198	broad.mit.edu	37	2	54161845	54161845	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:54161845C>T	ENST00000404125.1	-	8	909	c.854G>A	c.(853-855)aGa>aAa	p.R285K	PSME4_ENST00000421748.2_Intron	NM_014614.2	NP_055429.2	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator subunit 4	285					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			breast(5)|endometrium(8)|kidney(1)|large_intestine(11)|lung(26)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(2)	60			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GTTCAAGCTTCTCAGAATTCT	0.328000													11	19					0	0	1	0	0
LINC00969	440993	broad.mit.edu	37	3	195400728	195400728	+	RNA	SNP	A	A	G	rs12107841	by1000genomes	TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:195400728A>G	ENST00000445430.1	+	0	1324																											GATTGTGCCCAGCCTGTACGC	0.587000													6	44					0	0	1	0	0
SOCS6	9306	broad.mit.edu	37	18	67993328	67993328	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr18:67993328C>T	ENST00000397942.3	+	2	1740	c.1424C>T	c.(1423-1425)tCt>tTt	p.S475F	SOCS6_ENST00000582322.1_Missense_Mutation_p.S475F	NM_004232.3	NP_004223.2	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	475	SH2.				defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm				NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)	22		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				TATTCAAGGTCTCGGCTGCCT	0.468000													8	23					0	0	1	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													7	37					0	0	1	0	0
HIAT1	64645	broad.mit.edu	37	1	100533575	100533575	+	Missense_Mutation	SNP	A	A	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:100533575A>G	ENST00000370152.3	+	6	665	c.529A>G	c.(529-531)Att>Gtt	p.I177V	RP4-714D9.2_ENST00000432294.1_RNA	NM_033055.2	NP_149044.2	Q96MC6	HIAT1_HUMAN	hippocampus abundant transcript 1	177					transmembrane transport	integral to membrane|plasma membrane	transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(8)|skin(1)	16		all_epithelial(167;2.96e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0832)|all cancers(265;0.136)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.195)		CAGTCCTGCAATTGGAGCTTA	0.423000													25	99					0	0	1	0	0
DEFB112	245915	broad.mit.edu	37	6	50011374	50011374	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:50011374C>T	ENST00000322246.4	-	2	255	c.256G>A	c.(256-258)Gaa>Aaa	p.E86K		NM_001037498.1	NP_001032587.1	Q30KQ8	DB112_HUMAN	defensin, beta 112	86					defense response to bacterium	extracellular region		p.E86K(1)		central_nervous_system(1)|large_intestine(3)|lung(12)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	19	Lung NSC(77;0.042)					GGGTCACATTCTGTCACGCAG	0.428000													38	44					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186024579	186024579	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:186024579G>C	ENST00000271588.4	+	45	7146	c.6917G>C	c.(6916-6918)cGa>cCa	p.R2306P	HMCN1_ENST00000367492.2_Missense_Mutation_p.R2306P	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	2306	Ig-like C2-type 21.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						ATTGTGACCCGAGGGAAGAGT	0.473000													18	50					0	0	1	0	0
CDIPT	10423	broad.mit.edu	37	16	29871946	29871946	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:29871946C>T	ENST00000219789.6	-	4	1248	c.370G>A	c.(370-372)Gac>Aac	p.D124N	CDIPT_ENST00000563415.1_Missense_Mutation_p.D124N|CDIPT_ENST00000566113.1_Missense_Mutation_p.D79N|CDIPT_ENST00000561555.1_Missense_Mutation_p.D148N|CDIPT_ENST00000570016.1_Missense_Mutation_p.D124N|CDIPT_ENST00000569956.1_Missense_Mutation_p.D124N	NM_006319.3	NP_006310.1	O14735	CDIPT_HUMAN	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	124						endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity|phosphatidylinositol transporter activity			endometrium(1)|lung(3)	4						CCGGACAAGTCGATCATCTTG	0.552000													29	25					0	0	1	0	0
CEACAM6	4680	broad.mit.edu	37	19	42265240	42265240	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:42265240G>A	ENST00000199764.6	+	3	726	c.508G>A	c.(508-510)Gag>Aag	p.E170K	AC011513.4_ENST00000601409.1_RNA	NM_002483.4	NP_002474.3	P40199	CEAM6_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)	170	Ig-like C2-type 1.				cell-cell signaling|signal transduction	anchored to membrane|integral to plasma membrane				breast(1)|kidney(4)|large_intestine(1)|lung(4)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	18				OV - Ovarian serous cystadenocarcinoma(3;0.00575)|all cancers(3;0.0352)|Epithelial(262;0.0797)		CTGTGAACCTGAGGTTCAGAA	0.567000													32	174					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30705783	30705783	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:30705783C>T	ENST00000256246.2	-	1	825	c.751G>A	c.(751-753)Gaa>Aaa	p.E251K		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	251										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TGCTTTTCTTCATGTTTGGAA	0.313000													29	64					0	0	1	0	0
GIMAP1	170575	broad.mit.edu	37	7	150417212	150417212	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:150417212G>A	ENST00000307194.5	+	3	260	c.120G>A	c.(118-120)aaG>aaA	p.K40K		NM_130759.3	NP_570115.1			GTPase, IMAP family member 1											NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGGCCGGGAAGAGCGCCACTG	0.622000													60	71					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49690244	49690244	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:49690244G>A	ENST00000296452.4	+	5	3369	c.3255G>A	c.(3253-3255)cgG>cgA	p.R1085R		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	1085					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GGGCCCAGCGGAGGCGAGAGC	0.657000													14	25					0	0	1	0	0
LRRC14B	389257	broad.mit.edu	37	5	195111	195111	+	Silent	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:195111C>A	ENST00000328278.3	+	2	1216	c.1188C>A	c.(1186-1188)ctC>ctA	p.L396L		NM_001080478.1	NP_001073947.1	A6NHZ5	LR14B_HUMAN	leucine rich repeat containing 14B	396										endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(1)|upper_aerodigestive_tract(2)	10						TCAAGTTCCTCGGGAACCCGC	0.667000													7	19					3.09899e-07	3.23945e-07	1	1	0
AAGAB	79719	broad.mit.edu	37	15	67495199	67495199	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:67495199C>G	ENST00000261880.5	-	10	1012	c.908G>C	c.(907-909)aGa>aCa	p.R303T	AAGAB_ENST00000561452.1_Missense_Mutation_p.R194T|AAGAB_ENST00000538028.1_5'UTR|AAGAB_ENST00000542650.1_Missense_Mutation_p.R194T	NM_001271885.1|NM_001271886.1|NM_024666.3	NP_001258814.1|NP_001258815.1|NP_078942.3	Q6PD74	AAGAB_HUMAN	alpha- and gamma-adaptin binding protein	303					protein transport	cytoplasm				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)	9						AATTTCATCTCTGTCTCCCCC	0.433000													9	37					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41078260	41078260	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:41078260G>A	ENST00000352632.3	+	35	7596	c.7510G>A	c.(7510-7512)Gag>Aag	p.E2504K	SPTBN4_ENST00000593816.1_3'UTR|SPTBN4_ENST00000598249.1_Missense_Mutation_p.E2504K|SPTBN4_ENST00000392025.1_Missense_Mutation_p.E1247K			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	2504	PH.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGATGGCAGTGAGTTTTTGCT	0.592000													24	49					0	0	1	0	0
TRAK1	22906	broad.mit.edu	37	3	42234674	42234674	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:42234674G>C	ENST00000327628.5	+	8	1277	c.877G>C	c.(877-879)Gat>Cat	p.D293H	TRAK1_ENST00000396175.1_Missense_Mutation_p.D235H|TRAK1_ENST00000487159.1_3'UTR|TRAK1_ENST00000341421.3_Missense_Mutation_p.D235H|TRAK1_ENST00000449246.1_Missense_Mutation_p.D219H	NM_001042646.2	NP_001036111.1	Q9UPV9	TRAK1_HUMAN	trafficking protein, kinesin binding 1	293	HAP1 N-terminal.				endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	22						GCAAATAGTTGATTTGCAGAA	0.478000													21	52					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103347297	103347297	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:103347297C>T	ENST00000358392.2	-	65	5349	c.5032G>A	c.(5032-5034)Gag>Aag	p.E1678K	COL11A1_ENST00000370096.3_Missense_Mutation_p.E1666K|COL11A1_ENST00000353414.4_Missense_Mutation_p.E1627K|COL11A1_ENST00000512756.1_Missense_Mutation_p.E1550K	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1666	Fibrillar collagen NC1.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CCTGGTTTCTCCTTTGGCCAT	0.323000													12	30					0	0	1	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2867251	2867251	+	Silent	SNP	G	G	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:2867251G>T	ENST00000254695.8	+	7	471	c.381G>T	c.(379-381)ggG>ggT	p.G127G	RAP1GAP2_ENST00000540393.2_Silent_p.G108G|CTD-3060P21.1_ENST00000574885.1_RNA|RAP1GAP2_ENST00000366401.4_Silent_p.G112G|RAP1GAP2_ENST00000542807.1_Silent_p.G127G	NM_015085.4	NP_055900.4	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2	127					regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	11						CATCGCTGGGGAGCAGCATCT	0.602000													12	14					5.50884e-06	5.70199e-06	1	1	0
WIZ	58525	broad.mit.edu	37	19	15537870	15537870	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:15537870C>A	ENST00000389282.4	-	6	3788	c.3575G>T	c.(3574-3576)gGg>gTg	p.G1192V	WIZ_ENST00000599686.3_Missense_Mutation_p.G376V|WIZ_ENST00000263381.7_Missense_Mutation_p.G335V|WIZ_ENST00000545156.1_Missense_Mutation_p.G506V|WIZ_ENST00000599910.2_Missense_Mutation_p.G509V			O95785	WIZ_HUMAN	widely interspaced zinc finger motifs	1192						nucleus	zinc ion binding	p.E331fs*9(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	24						ATGAAGGGCCCCCGGCAGCAT	0.612000													26	55					2.44723e-14	2.6289e-14	1	1	0
GPR128	84873	broad.mit.edu	37	3	100368557	100368557	+	Nonsense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:100368557C>T	ENST00000273352.3	+	11	1553	c.1285C>T	c.(1285-1287)Caa>Taa	p.Q429*	GPR128_ENST00000475887.1_Nonsense_Mutation_p.Q134*	NM_032787.2	NP_116176.2	Q96K78	GP128_HUMAN	G protein-coupled receptor 128	429					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	56						AAAGGATTATCAATATCCCAA	0.363000													22	39					0	0	1	0	0
ERBB2IP	55914	broad.mit.edu	37	5	65342323	65342323	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:65342323C>G	ENST00000284037.5	+	18	2134	c.1745C>G	c.(1744-1746)tCt>tGt	p.S582C	ERBB2IP_ENST00000508515.1_Missense_Mutation_p.S582C|ERBB2IP_ENST00000511297.1_Missense_Mutation_p.S578C|ERBB2IP_ENST00000506030.1_Missense_Mutation_p.S582C|ERBB2IP_ENST00000380938.2_Missense_Mutation_p.S582C|ERBB2IP_ENST00000380936.1_Missense_Mutation_p.S582C|ERBB2IP_ENST00000380939.2_Missense_Mutation_p.S582C|ERBB2IP_ENST00000380935.1_Missense_Mutation_p.S582C|ERBB2IP_ENST00000380943.2_Missense_Mutation_p.S582C|ERBB2IP_ENST00000416865.2_Intron	NM_001253697.1	NP_001240626.1	Q96RT1	LAP2_HUMAN	erbb2 interacting protein	582					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(3)|skin(2)	36		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		ATGAAAGCCTCTGAGAACTTG	0.328000													36	117					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152605289	152605289	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:152605289G>C	ENST00000367255.5	-	96	18632	c.18031C>G	c.(18031-18033)Ctc>Gtc	p.L6011V	SYNE1_ENST00000448038.1_Missense_Mutation_p.L5940V|SYNE1_ENST00000341594.5_Missense_Mutation_p.L5623V|SYNE1_ENST00000356820.4_Missense_Mutation_p.L535V|SYNE1_ENST00000265368.4_Missense_Mutation_p.L6011V|SYNE1_ENST00000423061.1_Missense_Mutation_p.L5940V	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6011					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGGAGCATGAGAATCTCATCC	0.507000										HNSCC(10;0.0054)			15	14					0	0	1	0	0
HSPA9	3313	broad.mit.edu	37	5	137906739	137906739	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:137906739C>T	ENST00000297185.3	-	4	445	c.320G>A	c.(319-321)cGa>cAa	p.R107Q		NM_004134.6	NP_004125.3	P38646	GRP75_HUMAN	heat shock 70kDa protein 9 (mortalin)	107					anti-apoptosis|protein folding	cell surface|mitochondrial nucleoid	ATP binding|unfolded protein binding			breast(2)|endometrium(1)|kidney(4)|large_intestine(8)|lung(12)|upper_aerodigestive_tract(1)	28			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GACAGCCTGTCGCTTGGCCGG	0.502000													18	66					0	0	1	0	0
TDRD6	221400	broad.mit.edu	37	6	46656421	46656421	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:46656421G>C	ENST00000544460.1	+	1	810	c.556G>C	c.(556-558)Gat>Cat	p.D186H	TDRD6_ENST00000316081.6_Missense_Mutation_p.D186H	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	186					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			GGAGGTGCCTGATGTGTTCCA	0.652000													27	63					0	0	1	0	0
LEMD3	23592	broad.mit.edu	37	12	65634745	65634745	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:65634745C>G	ENST00000308330.2	+	9	2209	c.2183C>G	c.(2182-2184)tCt>tGt	p.S728C		NM_001167614.1|NM_014319.4	NP_001161086.1|NP_055134.2	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	728	Interaction with SMAD1, SMAD2, SMAD3 and SMAD5.				negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	36			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		GCTAATGAGTCTAGAGTTCGC	0.413000													23	34					0	0	1	0	0
FUT7	2529	broad.mit.edu	37	9	139925703	139925703	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr9:139925703G>A	ENST00000314412.6	-	2	1506	c.488C>T	c.(487-489)tCg>tTg	p.S163L	C9orf139_ENST00000314330.2_Intron	NM_004479.3	NP_004470.1	Q11130	FUT7_HUMAN	fucosyltransferase 7 (alpha (1,3) fucosyltransferase)	163					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			NS(1)|endometrium(1)|lung(4)|ovary(1)|skin(1)	8	all_cancers(76;0.0893)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		CAGCGGTGGCGAGGGCCCCCA	0.682000													6	4					0	0	1	0	0
AFAP1L2	84632	broad.mit.edu	37	10	116060048	116060048	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:116060048C>T	ENST00000369271.3	-	15	2162	c.1862G>A	c.(1861-1863)aGa>aAa	p.R621K	AFAP1L2_ENST00000304129.4_Missense_Mutation_p.R621K|AFAP1L2_ENST00000491814.1_5'UTR|AFAP1L2_ENST00000545353.1_Missense_Mutation_p.R674K	NM_001001936.1|NM_032550.2	NP_001001936.1|NP_115939.1	Q8N4X5	AF1L2_HUMAN	actin filament associated protein 1-like 2	621					inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|prostate(2)	21		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		GAAGGAGATTCTCTGCTGTTC	0.597000													44	52					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132474528	132474528	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:132474528G>A	ENST00000333577.4	+	9	2646	c.2537G>A	c.(2536-2538)cGc>cAc	p.R846H	EP400_ENST00000389561.2_Missense_Mutation_p.R810H|EP400_ENST00000330386.6_Missense_Mutation_p.R810H|EP400_ENST00000332482.4_Missense_Mutation_p.R773H|EP400_ENST00000389562.2_Missense_Mutation_p.R809H			Q96L91	EP400_HUMAN	E1A binding protein p400	846	HSA.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		ACTGTGGTGCGCCATCACGAG	0.478000													15	27					0	0	1	0	0
C19orf12	83636	broad.mit.edu	37	19	30199165	30199165	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:30199165G>A	ENST00000323670.9	-	2	295	c.156C>T	c.(154-156)gcC>gcT	p.A52A	C19orf12_ENST00000392275.1_Intron|C19orf12_ENST00000392276.1_Intron|C19orf12_ENST00000592153.1_Silent_p.A52A|C19orf12_ENST00000392278.2_Silent_p.A63A	NM_001256047.1|NM_031448.4	NP_001242976.1|NP_113636.2	Q9NSK7	CS012_HUMAN	chromosome 19 open reading frame 12	52						integral to membrane						Ovarian(5;0.000567)|Breast(6;0.0203)|Esophageal squamous(110;0.239)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|STAD - Stomach adenocarcinoma(5;1.7e-06)|Lung(7;0.0435)|LUAD - Lung adenocarcinoma(5;0.0989)|BRCA - Breast invasive adenocarcinoma(6;0.183)			ACTTACCAACGGCGAGTCCCG	0.617000													40	244					0	0	1	0	0
LRPPRC	10128	broad.mit.edu	37	2	44145529	44145529	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:44145529C>G	ENST00000260665.7	-	28	2962	c.2905G>C	c.(2905-2907)Ggt>Cgt	p.G969R		NM_133259.3	NP_573566.2	P42704	LPPRC_HUMAN	leucine-rich pentatricopeptide repeat containing	969					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			breast(3)|endometrium(3)|kidney(5)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|skin(2)	41		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TGCCAGTCACCGTTTATTTCT	0.294000													4	40					0	0	1	0	0
OR4L1	122742	broad.mit.edu	37	14	20528872	20528872	+	Silent	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr14:20528872C>G	ENST00000315683.1	+	1	669	c.669C>G	c.(667-669)gtC>gtG	p.V223V		NM_001004717.1	NP_001004717.1	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L, member 1	223					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(16)|ovary(2)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		TCATCCTGGTCAGTGTACCAA	0.438000													44	45					0	0	1	0	0
RUFY2	55680	broad.mit.edu	37	10	70105555	70105555	+	Silent	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:70105555G>C	ENST00000388768.2	-	18	2222	c.1896C>G	c.(1894-1896)ctC>ctG	p.L632L	RUFY2_ENST00000602465.1_Silent_p.L597L|RUFY2_ENST00000265865.3_Silent_p.L187L	NM_017987.4	NP_060457.4	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain containing 2	646						nucleus	metal ion binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|upper_aerodigestive_tract(2)	20						ATCTCTGAATGAGCAGTGCAT	0.398000													24	45					0	0	1	0	0
IGHV3-64	28414	broad.mit.edu	37	14	107113899	107113899	+	RNA	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr14:107113899C>G	ENST00000454421.2	-	0	272																											GAAACATATTCCAGTCCCTTC	0.522000													34	157					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50764749	50764749	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:50764749G>A	ENST00000440075.2	+	21	2489	c.2442G>A	c.(2440-2442)ctG>ctA	p.L814L	MYH14_ENST00000596571.1_Silent_p.L773L|MYH14_ENST00000262269.8_Silent_p.L814L|MYH14_ENST00000425460.1_Silent_p.L781L|MYH14_ENST00000376970.2_Silent_p.L806L|MYH14_ENST00000601313.1_Silent_p.L814L|MYH14_ENST00000598205.1_Silent_p.L781L			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	773	IQ.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		CGCTGGAACTGGACCCCAACC	0.642000													11	68					0	0	1	0	0
CNOT1	23019	broad.mit.edu	37	16	58568057	58568057	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:58568057C>T	ENST00000317147.5	-	40	6221	c.5889G>A	c.(5887-5889)ctG>ctA	p.L1963L	CNOT1_ENST00000569240.1_Silent_p.L1958L|CNOT1_ENST00000245138.4_Silent_p.L814L	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1963					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		AGACCTTGTTCAGCAGATTAA	0.383000													3	22					0	0	1	0	0
MIR320A	407037	broad.mit.edu	37	8	22102517	22102517	+	RNA	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:22102517C>T	ENST00000385302.1	-	0	39					NR_029714.1																						TTTCCCGACTCCGGGAAGAAC	0.657000													13	53					0	0	1	0	0
CORO1B	57175	broad.mit.edu	37	11	67209533	67209533	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:67209533C>T	ENST00000393893.1	-	4	331	c.228G>A	c.(226-228)ccG>ccA	p.P76P	CORO1B_ENST00000453768.2_Silent_p.P76P|CORO1B_ENST00000341356.5_Silent_p.P76P|CORO1B_ENST00000545016.1_Silent_p.P76P	NM_001018070.2	NP_001018080.1	Q9BR76	COR1B_HUMAN	coronin, actin binding protein, 1B	76					actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin filament binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	13			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			CACACACCGTCGGGTAGGCCT	0.632000													26	19					0	0	1	0	0
HSPA4L	22824	broad.mit.edu	37	4	128751932	128751932	+	Nonsense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr4:128751932C>G	ENST00000296464.4	+	18	2717	c.2306C>G	c.(2305-2307)tCa>tGa	p.S769*	HSPA4L_ENST00000508776.1_Nonsense_Mutation_p.S769*|HSPA4L_ENST00000505726.1_Nonsense_Mutation_p.S743*|HSPA4L_ENST00000439123.2_Nonsense_Mutation_p.S800*	NM_014278.2	NP_055093.2	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like						protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	31						GTAAAAGTTTCAGAAATAGTA	0.318000													9	23					0	0	1	0	0
MSTO1	55154	broad.mit.edu	37	1	155582033	155582033	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:155582033G>C	ENST00000245564.2	+	8	763	c.739G>C	c.(739-741)Gag>Cag	p.E247Q	MSTO1_ENST00000368341.4_Missense_Mutation_p.E212Q|MSTO1_ENST00000483734.1_3'UTR|MSTO1_ENST00000538143.1_Intron|MSTO1_ENST00000452804.2_Intron	NM_001256532.1|NM_001256533.1|NM_018116.3	NP_001243461.1|NP_001243462.1|NP_060586.2	Q9BUK6	MSTO1_HUMAN	misato 1, mitochondrial distribution and morphology regulator	247					mitochondrion distribution|protein polymerization	mitochondrial outer membrane|protein complex				breast(2)|endometrium(1)|lung(3)|skin(1)	7	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)					GAAGGCGGCAGAGCTGCTACA	0.542000													8	66					0	0	1	0	0
TFAP2D	83741	broad.mit.edu	37	6	50696729	50696729	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:50696729G>C	ENST00000008391.3	+	4	987	c.759G>C	c.(757-759)ttG>ttC	p.L253F	TFAP2D_ENST00000492804.1_3'UTR	NM_172238.3	NP_758438.2	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 delta (activating enhancer binding protein 2 delta)	253							DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(26)|ovary(6)|pancreas(1)|prostate(5)|stomach(1)	60	Lung NSC(77;0.0334)					GAGGCATTTTGAGAAGGTAAG	0.443000													36	59					0	0	1	0	0
ABCB4	5244	broad.mit.edu	37	7	87074215	87074215	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:87074215C>G	ENST00000265723.4	-	10	1193	c.1082G>C	c.(1081-1083)aGa>aCa	p.R361T	ABCB4_ENST00000358400.3_Missense_Mutation_p.R361T|ABCB4_ENST00000453593.1_Missense_Mutation_p.R361T|ABCB4_ENST00000359206.3_Missense_Mutation_p.R361T|ABCB4_ENST00000545634.1_Missense_Mutation_p.R361T	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	361					cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					TGCTGCTCCTCTTGCATTGGC	0.348000													10	25					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48703691	48703691	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:48703691C>T	ENST00000352832.5	+	34	6704	c.6332C>T	c.(6331-6333)cCa>cTa	p.P2111L	CACNA1G_ENST00000515765.1_Missense_Mutation_p.P2182L|CACNA1G_ENST00000507896.1_Missense_Mutation_p.P2055L|CACNA1G_ENST00000358244.5_Missense_Mutation_p.P2032L|CACNA1G_ENST00000510366.1_Missense_Mutation_p.P2093L|CACNA1G_ENST00000515411.1_Missense_Mutation_p.P2175L|CACNA1G_ENST00000512389.1_Missense_Mutation_p.P2134L|CACNA1G_ENST00000507510.2_Missense_Mutation_p.P2193L|CACNA1G_ENST00000503485.1_Missense_Mutation_p.P2111L|CACNA1G_ENST00000359106.5_Missense_Mutation_p.P2238L|CACNA1G_ENST00000514717.1_Missense_Mutation_p.P2088L|CACNA1G_ENST00000513964.1_Missense_Mutation_p.P2100L|CACNA1G_ENST00000507609.1_Missense_Mutation_p.P2138L|CACNA1G_ENST00000429973.2_Missense_Mutation_p.P2127L|CACNA1G_ENST00000354983.4_Missense_Mutation_p.P2204L|CACNA1G_ENST00000513689.2_Missense_Mutation_p.P2148L|CACNA1G_ENST00000507336.1_Missense_Mutation_p.P2227L|CACNA1G_ENST00000510115.1_Missense_Mutation_p.P2159L|CACNA1G_ENST00000505165.1_Missense_Mutation_p.P2066L|CACNA1G_ENST00000515165.1_Missense_Mutation_p.P2145L|CACNA1G_ENST00000442258.2_Missense_Mutation_p.P2104L|CACNA1G_ENST00000502264.1_Missense_Mutation_p.P2167L|CACNA1G_ENST00000514181.1_Missense_Mutation_p.P2120L|CACNA1G_ENST00000514079.1_Missense_Mutation_p.P2152L|CACNA1G_ENST00000360761.4_Missense_Mutation_p.P2122L	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	2238					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GAGGAGCCCCCATCCCCACGG	0.647000											OREG0024569	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	20					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151161124	151161124	+	Nonsense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:151161124G>A	ENST00000282466.3	-	5	5610	c.5611C>T	c.(5611-5613)Cag>Tag	p.Q1871*		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	1871	Ig-like C2-type 5.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ACGCTGGGCTGAGGAGTTCCT	0.433000													16	48					0	0	1	0	0
ITGA9	3680	broad.mit.edu	37	3	37567549	37567549	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:37567549G>A	ENST00000264741.5	+	13	1616	c.1360G>A	c.(1360-1362)Gtg>Atg	p.V454M	ITGA9_ENST00000422441.1_Missense_Mutation_p.V454M	NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	454					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		GTCCGACAGCGTGGTTCTTCT	0.517000													52	48					0	0	1	0	0
PRPF4B	8899	broad.mit.edu	37	6	4058989	4058989	+	Nonsense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:4058989C>T	ENST00000337659.6	+	14	2861	c.2761C>T	c.(2761-2763)Cag>Tag	p.Q921*	PRPF4B_ENST00000494674.1_3'UTR|PRPF4B_ENST00000538861.1_Nonsense_Mutation_p.Q907*	NM_003913.4	NP_003904.3	Q13523	PRP4B_HUMAN	pre-mRNA processing factor 4B	921	Protein kinase.					catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(6)|endometrium(3)|large_intestine(5)|lung(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	22	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				GTTCAAAGATCAGCATTTTGA	0.294000													24	85					0	0	1	0	0
GPR173	54328	broad.mit.edu	37	X	53106391	53106391	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chrX:53106391C>T	ENST00000332582.4	+	2	1079	c.588C>T	c.(586-588)ctC>ctT	p.L196L		NM_018969.5	NP_061842.1	Q9NS66	GP173_HUMAN	G protein-coupled receptor 173	196						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(1)	16						TGGCTGTGCTCATGGCAGCTA	0.537000													2	1					0	0	1	0	0
SF3A2	8175	broad.mit.edu	37	19	2246928	2246928	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:2246928C>T	ENST00000221494.5	+	7	871	c.453C>T	c.(451-453)ttC>ttT	p.F151F		NM_007165.4	NP_009096.2	Q15428	SF3A2_HUMAN	splicing factor 3a, subunit 2, 66kDa						nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex	nucleic acid binding|zinc ion binding			NS(1)|large_intestine(1)|lung(2)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTCACCGCTTCATGTCTGCGT	0.647000													13	37					0	0	1	0	0
LMBRD2	92255	broad.mit.edu	37	5	36123048	36123048	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:36123048G>C	ENST00000296603.4	-	8	1300	c.838C>G	c.(838-840)Cag>Gag	p.Q280E		NM_001007527.1	NP_001007528.1	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	280						integral to membrane				breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ATTTTTTCCTGATACTCTGTA	0.254000													20	28					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1104234	1104234	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:1104234C>T	ENST00000441003.2	+	49	8452	c.8425C>T	c.(8425-8427)Cgc>Tgc	p.R2809C		NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	5171						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CCGGGCCCGGCGCTCCCCTAG	0.697000													9	10					0	0	1	0	0
PDPK1	5170	broad.mit.edu	37	16	2647187	2647187	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:2647187C>T	ENST00000342085.4	+	13	1614	c.1465C>T	c.(1465-1467)Cct>Tct	p.P489S	PDPK1_ENST00000268673.7_Missense_Mutation_p.P362S|PDPK1_ENST00000441549.3_Intron|PDPK1_ENST00000389224.3_Missense_Mutation_p.P462S|PDPK1_ENST00000354836.5_Missense_Mutation_p.P465S	NM_002613.4	NP_002604.1	O15530	PDPK1_HUMAN	3-phosphoinositide dependent protein kinase-1	489	PH.				actin cytoskeleton organization|activation of protein kinase B activity|insulin receptor signaling pathway|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|peptidyl-threonine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|synaptic transmission|T cell costimulation|T cell receptor signaling pathway	cytosol|nucleoplasm|plasma membrane	3-phosphoinositide-dependent protein kinase activity|ATP binding			central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(2)|ovary(1)	7		Ovarian(90;0.17)			Celecoxib(DB00482)	TTATGTGGATCCTGTCAACAA	0.438000													40	24					0	0	1	0	0
FAM179B	23116	broad.mit.edu	37	14	45473381	45473381	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr14:45473381C>G	ENST00000361462.2	+	4	2639	c.2456C>G	c.(2455-2457)cCt>cGt	p.P819R	KLHL28_ENST00000553817.1_Intron|FAM179B_ENST00000361577.3_Missense_Mutation_p.P819R|FAM179B_ENST00000382233.2_Missense_Mutation_p.P819R			Q9Y4F4	F179B_HUMAN	family with sequence similarity 179, member B	819							binding			endometrium(4)|kidney(5)|large_intestine(12)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	45						CCATCCTATCCTGTCTCATCA	0.398000													21	27					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39425236	39425236	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr13:39425236G>C	ENST00000280481.7	+	10	6949	c.6733G>C	c.(6733-6735)Gat>Cat	p.D2245H		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2245	Calx-beta 5.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GATCCGAGATGATGCTGATAG	0.428000													15	51					0	0	1	0	0
DNPH1	10591	broad.mit.edu	37	6	43193581	43193581	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:43193581G>A	ENST00000230431.6	-	4	442	c.415C>T	c.(415-417)Cgg>Tgg	p.R139W	DNPH1_ENST00000393987.2_3'UTR	NM_006443.2	NP_006434.1			2'-deoxynucleoside 5'-phosphate N-hydrolase 1																		ACCTGGAACCGAGAGCCATCT	0.627000													10	43					0	0	1	0	0
GRIN2D	2906	broad.mit.edu	37	19	48917338	48917338	+	Silent	SNP	C	C	T	rs138100955		TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:48917338C>T	ENST00000263269.3	+	4	1264	c.1176C>T	c.(1174-1176)ctC>ctT	p.L392L		NM_000836.2	NP_000827.2	O15399	NMDE4_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	392						cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			autonomic_ganglia(1)|breast(6)|endometrium(2)|large_intestine(9)|lung(12)|ovary(5)|pancreas(1)|prostate(1)	37		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	TCATCTCCCTCACCAGAGACA	0.592000													15	32					0	0	1	0	0
PTRF	284119	broad.mit.edu	37	17	40556833	40556833	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:40556833C>T	ENST00000357037.5	-	2	1464	c.1045G>A	c.(1045-1047)Gac>Aac	p.D349N		NM_012232.5	NP_036364.2	Q6NZI2	PTRF_HUMAN	polymerase I and transcript release factor	349					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription initiation from RNA polymerase I promoter	caveola|cytosol|endoplasmic reticulum|microsome|mitochondrion|nucleoplasm	protein binding|rRNA primary transcript binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|urinary_tract(1)	17		all_cancers(22;0.00146)|Breast(137;0.00116)|all_epithelial(22;0.0134)		BRCA - Breast invasive adenocarcinoma(366;0.193)		CCGCCCTCGTCGTCGTCGGCG	0.706000													6	33					0	0	1	0	0
KCNMB4	27345	broad.mit.edu	37	12	70760712	70760712	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:70760712C>G	ENST00000258111.4	+	1	657	c.198C>G	c.(196-198)ttC>ttG	p.F66L		NM_014505.5	NP_055320.4	Q86W47	KCMB4_HUMAN	potassium large conductance calcium-activated channel, subfamily M, beta member 4	66					detection of calcium ion|platelet activation|regulation of action potential in neuron|regulation of neurotransmitter secretion|regulation of vasoconstriction|synaptic transmission	voltage-gated potassium channel complex	calcium-activated potassium channel activity|protein binding			kidney(1)|large_intestine(4)|lung(5)	10	Renal(347;0.236)		Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)			GCGAGGTGTTCGAGTGCACCT	0.627000													6	34					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117232356	117232356	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:117232356C>T	ENST00000003084.6	+	14	2267	c.2135C>T	c.(2134-2136)tCc>tTc	p.S712F	CFTR_ENST00000454343.1_Missense_Mutation_p.S651F	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	712					respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	CGAAAATTTTCCATTGTGCAA	0.383000									Cystic Fibrosis				9	27					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152193663	152193663	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:152193663G>C	ENST00000368801.2	-	3	517	c.442C>G	c.(442-444)Ctt>Gtt	p.L148V	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	148					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCAGGTTTAAGACTTCCTCTG	0.423000													67	133					0	0	1	0	0
TMEM206	55248	broad.mit.edu	37	1	212558702	212558702	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:212558702G>A	ENST00000261455.4	-	4	546	c.409C>T	c.(409-411)Cct>Tct	p.P137S	TMEM206_ENST00000535273.1_Missense_Mutation_p.P198S|TMEM206_ENST00000471937.1_5'UTR	NM_018252.2	NP_060722.2	Q9H813	TM206_HUMAN	transmembrane protein 206	137						integral to membrane				breast(1)|kidney(3)|large_intestine(4)|lung(6)|prostate(1)|skin(2)	17				all cancers(67;0.012)|OV - Ovarian serous cystadenocarcinoma(81;0.0121)|GBM - Glioblastoma multiforme(131;0.0377)|Epithelial(68;0.148)		CTTGTCAGAGGAGGAATGACC	0.537000													18	23					0	0	1	0	0
ZKSCAN5	23660	broad.mit.edu	37	7	99129756	99129756	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:99129756C>A	ENST00000394170.2	+	7	2655	c.2404C>A	c.(2404-2406)Caa>Aaa	p.Q802K	ZKSCAN5_ENST00000326775.5_Missense_Mutation_p.Q802K|ZKSCAN5_ENST00000451158.1_Missense_Mutation_p.Q802K	NM_014569.3	NP_055384.1	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	802					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	21	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GAAACCTTTTCAATGTAAAGA	0.403000													40	130					4.32679e-17	4.68895e-17	1	1	0
SARNP	84324	broad.mit.edu	37	12	56194387	56194387	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:56194387G>C	ENST00000546837.1	-	9	1146	c.1147C>G	c.(1147-1149)Ccc>Gcc	p.P383A	SARNP_ENST00000444631.2_Silent_p.L10L|SARNP_ENST00000552080.1_Silent_p.L70L|SARNP_ENST00000336133.3_Silent_p.L70L																							CTTTGACAGGGAGCTCAATGG	0.343000													9	62					0	0	1	0	0
ZBTB17	7709	broad.mit.edu	37	1	16268728	16268728	+	Silent	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:16268728G>C	ENST00000375733.2	-	16	2407	c.2169C>G	c.(2167-2169)ctC>ctG	p.L723L	ZBTB17_ENST00000375743.4_Silent_p.L716L|ZBTB17_ENST00000537142.1_Silent_p.L634L			Q13105	ZBT17_HUMAN	zinc finger and BTB domain containing 17	716	Interaction with HCFC1.				negative regulation of cell cycle	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(4)|large_intestine(1)|lung(4)|ovary(2)|prostate(2)	15		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|Colorectal(212;4.12e-07)|COAD - Colon adenocarcinoma(227;2.43e-05)|BRCA - Breast invasive adenocarcinoma(304;9.97e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		CACAGGCGTAGAGGATGTGAG	0.612000													11	52					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100683479	100683479	+	Missense_Mutation	SNP	A	A	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:100683479A>G	ENST00000306151.4	+	3	8846	c.8782A>G	c.(8782-8784)Act>Gct	p.T2928A		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2928	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TGAAGTAAGTACTCCATTAAC	0.493000													73	213					0	0	1	0	0
MYOZ2	51778	broad.mit.edu	37	4	120107138	120107138	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr4:120107138G>C	ENST00000307128.5	+	6	791	c.578G>C	c.(577-579)gGa>gCa	p.G193A		NM_016599.4	NP_057683.1	Q9NPC6	MYOZ2_HUMAN	myozenin 2	193							protein phosphatase 2B binding			endometrium(1)|large_intestine(6)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16						ACACCATTTGGAGGTTTTGAA	0.313000													29	39					0	0	1	0	0
WDR24	84219	broad.mit.edu	37	16	736875	736875	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:736875C>G	ENST00000293883.4	-	3	1960	c.1201G>C	c.(1201-1203)Gag>Cag	p.E401Q	WDR24_ENST00000248142.6_Missense_Mutation_p.E531Q	NM_032259.2	NP_115635.1	Q96S15	WDR24_HUMAN	WD repeat domain 24	531										breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|urinary_tract(3)	19		Hepatocellular(780;0.0218)				GGCTCCGTCTCAAAGACACTG	0.662000													10	6					0	0	1	0	0
HIST1H2AG	8969	broad.mit.edu	37	6	27100935	27100935	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:27100935G>C	ENST00000359193.2	+	1	104	c.85G>C	c.(85-87)Ggc>Cgc	p.G29R		NM_021064.4	NP_066408.1	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ag	29					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(4)|ovary(1)|urinary_tract(1)	17						GTTCCCCGTGGGCCGAGTGCA	0.672000													19	58					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48311847	48311847	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:48311847C>T	ENST00000435803.1	+	17	2608	c.2584C>T	c.(2584-2586)Cca>Tca	p.P862S		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	862					transport	integral to membrane	ATP binding|ATPase activity	p.P807T(1)|p.P862T(1)		breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TTTTTCTGTTCCAGAAAATGA	0.318000													45	40					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43441169	43441169	+	RNA	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:43441169G>A	ENST00000471557.1	-	0	161				PSG7_ENST00000406070.2_RNA|PSG7_ENST00000446844.3_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				CCTCACCTGTGAGCAGGAGCC	0.547000													35	63					0	0	1	0	0
IPCEF1	26034	broad.mit.edu	37	6	154481089	154481089	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:154481089C>T	ENST00000265198.4	-	12	1343	c.1188G>A	c.(1186-1188)atG>atA	p.M396I	IPCEF1_ENST00000422970.2_Missense_Mutation_p.M397I|OPRM1_ENST00000337049.4_Intron|IPCEF1_ENST00000367220.4_Missense_Mutation_p.M397I|IPCEF1_ENST00000519344.1_Missense_Mutation_p.M368I	NM_001130700.1|NM_015553.2	NP_001124172.1|NP_056368.1			interaction protein for cytohesin exchange factors 1											breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	12						GCAGGGTGTTCATGACTTTCC	0.502000													7	41					0	0	1	0	0
RSC1A1	6248	broad.mit.edu	37	1	15987793	15987793	+	Nonsense_Mutation	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:15987793C>A	ENST00000345034.1	+	1	1430	c.1430C>A	c.(1429-1431)tCa>tAa	p.S477*	DDI2_ENST00000480945.1_3'UTR	NM_006511.1	NP_006502.1	Q92681	RSCA1_HUMAN	regulatory solute carrier protein, family 1, member 1	477					negative regulation of transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transport	cell junction|Golgi apparatus|nucleus	ion channel inhibitor activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)	11		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00276)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.73e-07)|COAD - Colon adenocarcinoma(227;3.49e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000114)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ACTGTAACCTCAGCTAAAACA	0.438000													17	55					5.3912e-06	5.59593e-06	1	1	0
TMEM222	84065	broad.mit.edu	37	1	27657274	27657274	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:27657274C>T	ENST00000374076.4	+	2	296	c.258C>T	c.(256-258)ttC>ttT	p.F86F	TMEM222_ENST00000608611.1_Silent_p.F53F	NM_032125.2	NP_115501.2	Q9H0R3	TM222_HUMAN	transmembrane protein 222	86						integral to membrane	protein binding			biliary_tract(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	7						TTCGGGACTTCGCGGGCCCCT	0.582000													41	70					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10265435	10265435	+	Splice_Site	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:10265435C>T	ENST00000418404.3	-	4	668	c.505G>A	c.(505-507)Gat>Aat	p.D169N	MYH13_ENST00000252172.4_Splice_Site_p.D169N			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	169	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						AATTACTCACCAGTCAGCATG	0.468000													29	66					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124385474	124385474	+	Silent	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:124385474C>A	ENST00000368909.3	+	43	5380	c.5274C>A	c.(5272-5274)acC>acA	p.T1758T	DMBT1_ENST00000359586.6_Silent_p.T478T|DMBT1_ENST00000368955.3_Silent_p.T1748T|DMBT1_ENST00000344338.3_Silent_p.T1748T|DMBT1_ENST00000368956.2_Silent_p.T1130T|DMBT1_ENST00000338354.3_Silent_p.T1758T|DMBT1_ENST00000330163.4_Silent_p.T1130T	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1758	Poly-Thr.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CAACTACAACCACTGCAAGTA	0.398000													20	55					1.55795e-14	1.67604e-14	1	1	0
ZNF366	167465	broad.mit.edu	37	5	71756945	71756945	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:71756945G>C	ENST00000318442.5	-	2	869	c.379C>G	c.(379-381)Cag>Gag	p.Q127E		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	127					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		TCGATCATCTGAGAGTCATAC	0.592000													49	83					0	0	1	0	0
CD2BP2	10421	broad.mit.edu	37	16	30365073	30365073	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:30365073C>G	ENST00000305596.3	-	5	599	c.424G>C	c.(424-426)Gag>Cag	p.E142Q	CD2BP2_ENST00000569466.1_Missense_Mutation_p.E142Q	NM_006110.2	NP_006101.1	O95400	CD2B2_HUMAN	CD2 (cytoplasmic tail) binding protein 2	142					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			breast(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)	15						TCCTCCTCCTCCGAGTCTGAG	0.612000													15	8					0	0	1	0	0
TIGD7	91151	broad.mit.edu	37	16	3349687	3349687	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:3349687C>T	ENST00000396862.1	-	2	2756	c.928G>A	c.(928-930)Gag>Aag	p.E310K	TIGD7_ENST00000268674.2_Missense_Mutation_p.E310K	NM_033208.3	NP_149985.2	Q6NT04	TIGD7_HUMAN	tigger transposable element derived 7	310	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	12						CGACCATCCTCACTGGTTAGG	0.433000													25	20					0	0	1	0	0
SPG11	80208	broad.mit.edu	37	15	44859691	44859691	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:44859691G>A	ENST00000261866.7	-	36	6701	c.6685C>T	c.(6685-6687)Cgg>Tgg	p.R2229W	SPG11_ENST00000427534.2_Missense_Mutation_p.R2229W|SPG11_ENST00000535302.2_Missense_Mutation_p.R2116W	NM_025137.3	NP_079413.3	Q96JI7	SPTCS_HUMAN	spastic paraplegia 11 (autosomal recessive)	2229					cell death	cytosol|integral to membrane|nucleus	protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	72		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		CCAATCTCCCGGCACATGCTG	0.547000													7	43					0	0	1	0	0
ADRB1	153	broad.mit.edu	37	10	115804344	115804344	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:115804344C>T	ENST00000369295.2	+	1	539	c.453C>T	c.(451-453)gtC>gtT	p.V151V		NM_000684.2	NP_000675.1	P08588	ADRB1_HUMAN	adrenoceptor beta 1	151					positive regulation of cAMP biosynthetic process	integral to plasma membrane	alpha-2A adrenergic receptor binding|beta1-adrenergic receptor activity|protein heterodimerization activity			large_intestine(4)|lung(1)|upper_aerodigestive_tract(1)	6		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0124)|all cancers(201;0.0298)	Acebutolol(DB01193)|Alprenolol(DB00866)|Amiodarone(DB01118)|Arbutamine(DB01102)|Atenolol(DB00335)|Betaxolol(DB00195)|Bevantolol(DB01295)|Bisoprolol(DB00612)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Desipramine(DB01151)|Dobutamine(DB00841)|Dopamine(DB00988)|Epinephrine(DB00668)|Esmolol(DB00187)|Isoetharine(DB00221)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Metoprolol(DB00264)|Nadolol(DB01203)|Norepinephrine(DB00368)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Practolol(DB01297)|Propranolol(DB00571)|Risperidone(DB00734)|Timolol(DB00373)|Ziprasidone(DB00246)	CCCTGTGTGTCATTGCCCTGG	0.682000													43	49					0	0	1	0	0
MED19	219541	broad.mit.edu	37	11	57472219	57472219	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:57472219C>T	ENST00000337672.2	-	3	564	c.543G>A	c.(541-543)caG>caA	p.Q181Q	MED19_ENST00000431606.2_Silent_p.Q181Q	NM_153450.1	NP_703151.1	A0JLT2	MED19_HUMAN	mediator complex subunit 19	181	Lys-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				cervix(1)|large_intestine(1)|lung(1)|ovary(2)	5						GGGTACGGCTCTGTTTGTGCT	0.438000													33	57					0	0	1	0	0
PAM	5066	broad.mit.edu	37	5	102360917	102360917	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:102360917G>A	ENST00000438793.3	+	23	3038	c.2568G>A	c.(2566-2568)ctG>ctA	p.L856L	PAM_ENST00000379787.4_Silent_p.L236L|PAM_ENST00000274392.9_Silent_p.L758L|PAM_ENST00000304400.7_Silent_p.L856L|PAM_ENST00000455264.2_Intron|PAM_ENST00000346918.2_Intron|PAM_ENST00000348126.2_Silent_p.L749L	NM_000919.3|NM_001177306.1|NM_138766.2	NP_000910.2|NP_001170777.1|NP_620121.1	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	856					peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding			endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	25		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	AACAGAAACTGATCAAAGAGC	0.473000													36	49					0	0	1	0	0
PCDHGA12	26025	broad.mit.edu	37	5	140811994	140811994	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:140811994C>T	ENST00000252085.3	+	1	1810	c.1668C>T	c.(1666-1668)aaC>aaT	p.N556N	PCDHGB3_ENST00000576222.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA4_ENST00000571252.1_Intron	NM_003735.2|NM_032094.1	NP_003726.1|NP_115265.1														breast(2)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(23)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	58			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGACCAGAACGACAATGCGC	0.652000													39	140					0	0	1	0	0
BTBD7	55727	broad.mit.edu	37	14	93717919	93717919	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr14:93717919G>A	ENST00000334746.5	-	8	2139	c.1832C>T	c.(1831-1833)aCg>aTg	p.T611M	BTBD7_ENST00000393170.2_Missense_Mutation_p.T185M|BTBD7_ENST00000554565.1_Missense_Mutation_p.T260M	NM_001002860.2	NP_001002860.2	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7	611										breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(8)|upper_aerodigestive_tract(1)	35		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		CATGTAGAGCGTGTCTGGCAC	0.473000													24	77					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	10274188	10274188	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:10274188C>T	ENST00000396573.2	-	3	390	c.81G>A	c.(79-81)gcG>gcA	p.A27A	GRIN2A_ENST00000330684.3_Silent_p.A27A|GRIN2A_ENST00000396575.2_Silent_p.A27A|GRIN2A_ENST00000404927.2_Silent_p.A27A|GRIN2A_ENST00000562109.1_Silent_p.A27A	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	27					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GACCCTTCTCCGCCGCCGCGC	0.682000													6	49					0	0	1	0	0
AUTS2	26053	broad.mit.edu	37	7	69583172	69583172	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:69583172G>A	ENST00000342771.4	+	3	898	c.577G>A	c.(577-579)Gaa>Aaa	p.E193K	AUTS2_ENST00000403018.2_Missense_Mutation_p.E193K|AUTS2_ENST00000406775.2_Missense_Mutation_p.E193K	NM_015570.2	NP_056385.1	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2	193										breast(2)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	50		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		TGCCAGTGGAGAATCCAAGGG	0.423000													12	17					0	0	1	0	0
TDRD9	122402	broad.mit.edu	37	14	104472782	104472782	+	Missense_Mutation	SNP	A	A	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr14:104472782A>C	ENST00000409874.4	+	16	1818	c.1770A>C	c.(1768-1770)gaA>gaC	p.E590D	TDRD9_ENST00000339063.5_Missense_Mutation_p.E590D	NM_153046.2	NP_694591.2	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	590					cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				ATGATGGTGAATTGACCTTCT	0.388000													30	18					0	0	1	0	0
DRC1	92749	broad.mit.edu	37	2	26667166	26667166	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:26667166C>G	ENST00000288710.2	+	9	1179	c.1105C>G	c.(1105-1107)Cta>Gta	p.L369V	DRC1_ENST00000483675.1_3'UTR	NM_145038.2	NP_659475.2			dynein regulatory complex subunit 1 homolog (Chlamydomonas)																		GAACCAGTCTCTAACCTCGGA	0.423000													7	38					0	0	1	0	0
RNASEL	6041	broad.mit.edu	37	1	182554682	182554682	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:182554682G>C	ENST00000367559.3	-	2	1513	c.1260C>G	c.(1258-1260)ttC>ttG	p.F420L	RNASEL_ENST00000539397.1_Missense_Mutation_p.F420L|RNASEL_ENST00000444138.1_Missense_Mutation_p.F420L	NM_021133.3	NP_066956.1	Q05823	RN5A_HUMAN	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	420	Protein kinase.				mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(4)|prostate(1)|stomach(1)|urinary_tract(1)	27						CACTCCCATAGAATGTCACCA	0.542000													56	70					0	0	1	0	0
KIF13A	63971	broad.mit.edu	37	6	17781470	17781470	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:17781470G>A	ENST00000378814.5	-	29	3567	c.3568C>T	c.(3568-3570)Ctg>Ttg	p.L1190L	KIF13A_ENST00000378826.2_Silent_p.L1203L|KIF13A_ENST00000378816.5_Silent_p.L1203L|KIF13A_ENST00000259711.6_Silent_p.L1203L|KIF13A_ENST00000378843.2_Silent_p.L1190L	NM_001105568.2	NP_001099038.1	Q9H1H9	KI13A_HUMAN	kinesin family member 13A	1203					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TCCTTGGGCAGGATGGAGTTC	0.498000													7	103					0	0	1	0	0
YY1AP1	55249	broad.mit.edu	37	1	155658062	155658062	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:155658062C>T	ENST00000368340.5	-	1	302	c.194G>A	c.(193-195)gGa>gAa	p.G65E	YY1AP1_ENST00000407221.1_Intron|YY1AP1_ENST00000368330.2_Intron|YY1AP1_ENST00000405763.3_Missense_Mutation_p.G65E|YY1AP1_ENST00000476093.1_Intron|YY1AP1_ENST00000359205.5_Intron|DAP3_ENST00000471642.2_Intron|YY1AP1_ENST00000368339.5_Missense_Mutation_p.G65E|YY1AP1_ENST00000404643.1_Intron|YY1AP1_ENST00000438245.2_5'UTR|MSTO1_ENST00000538143.1_Intron|MSTO1_ENST00000452804.2_Intron|YY1AP1_ENST00000311573.5_5'UTR|YY1AP1_ENST00000361831.5_Intron|YY1AP1_ENST00000355499.4_Intron|YY1AP1_ENST00000295566.4_Intron|YY1AP1_ENST00000347088.5_Intron	NM_001198904.1	NP_001185833.1			YY1 associated protein 1											central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(7)|ovary(2)|skin(2)|urinary_tract(2)	31	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					GGAGGCGGATCCCGCAACCGA	0.647000													10	7					0	0	1	0	0
WIZ	58525	broad.mit.edu	37	19	15535493	15535493	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:15535493C>T	ENST00000389282.4	-	8	4744	c.4531G>A	c.(4531-4533)Gag>Aag	p.E1511K	WIZ_ENST00000599686.3_Missense_Mutation_p.E695K|WIZ_ENST00000263381.7_Missense_Mutation_p.E654K|WIZ_ENST00000545156.1_Missense_Mutation_p.E825K|WIZ_ENST00000599910.2_Missense_Mutation_p.E828K			O95785	WIZ_HUMAN	widely interspaced zinc finger motifs	1511						nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	24						AGAGGCCGCTCACCACCGTCG	0.746000													10	8					0	0	1	0	0
CHRNB2	1141	broad.mit.edu	37	1	154543710	154543710	+	Silent	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:154543710C>G	ENST00000368476.3	+	5	675	c.411C>G	c.(409-411)gtC>gtG	p.V137V		NM_000748.2	NP_000739.1	P17787	ACHB2_HUMAN	cholinergic receptor, nicotinic, beta 2 (neuronal)	137					B cell activation|behavioral response to nicotine|calcium ion transport|central nervous system projection neuron axonogenesis|lateral geniculate nucleus development|locomotory behavior|membrane depolarization|memory|negative regulation of action potential|optic nerve morphogenesis|positive regulation of B cell proliferation|positive regulation of dopamine secretion|regulation of circadian sleep/wake cycle, REM sleep|regulation of dendrite morphogenesis|regulation of dopamine metabolic process|regulation of synaptogenesis|response to cocaine|response to ethanol|response to hypoxia|sensory perception of pain|sensory perception of sound|smooth muscle contraction|social behavior|synaptic transmission involved in micturition|synaptic transmission, cholinergic|vestibulocochlear nerve development|visual learning|visual perception	cell junction|external side of plasma membrane|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|skin(1)|urinary_tract(3)	28	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)		Nicotine(DB00184)	ATGCCGTGGTCTCCTATGATG	0.542000													78	111					0	0	1	0	0
TMEM145	284339	broad.mit.edu	37	19	42828899	42828899	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:42828899G>A	ENST00000301204.3	+	15	1453	c.1412G>A	c.(1411-1413)cGa>cAa	p.R471Q		NM_173633.2	NP_775904.2	Q8NBT3	TM145_HUMAN	transmembrane protein 145	471						integral to membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	27		Prostate(69;0.00682)				CCCCTGCCCCGAGCGGCGCCG	0.741000													3	7					0	0	1	0	0
CD2BP2	10421	broad.mit.edu	37	16	30365994	30365994	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:30365994C>T	ENST00000305596.3	-	2	184	c.9G>A	c.(7-9)aaG>aaA	p.K3K	CD2BP2_ENST00000569466.1_Silent_p.K3K	NM_006110.2	NP_006101.1	O95400	CD2B2_HUMAN	CD2 (cytoplasmic tail) binding protein 2	3					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			breast(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)	15						TCACTTTCCTCTTTGGCATGA	0.562000													45	101					0	0	1	0	0
KMT2E	55904	broad.mit.edu	37	7	104681451	104681451	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:104681451G>A	ENST00000334877.4	+	3	586	c.52G>A	c.(52-54)Gaa>Aaa	p.E18K	KMT2E_ENST00000334914.7_5'UTR|KMT2E_ENST00000311117.3_Missense_Mutation_p.E18K|KMT2E_ENST00000257745.4_Missense_Mutation_p.E18K|KMT2E_ENST00000476671.1_Missense_Mutation_p.E18K					lysine (K)-specific methyltransferase 2E																		GTCATACTTGGAAATGGCTGC	0.398000													12	68					0	0	1	0	0
IFI44L	10964	broad.mit.edu	37	1	79101035	79101035	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:79101035C>T	ENST00000370751.5	+	5	916	c.737C>T	c.(736-738)tCt>tTt	p.S246F	IFI44L_ENST00000476521.1_3'UTR|IFI44L_ENST00000342282.3_5'UTR	NM_006820.2	NP_006811.2	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like							cytoplasm				endometrium(4)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	22						AGGATATATTCTGTTAAAGAT	0.358000													22	47					0	0	1	0	0
FUBP3	8939	broad.mit.edu	37	9	133470931	133470931	+	Nonsense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr9:133470931C>G	ENST00000319725.9	+	2	221	c.146C>G	c.(145-147)tCa>tGa	p.S49*		NM_003934.1	NP_003925.1	Q96I24	FUBP3_HUMAN	far upstream element (FUSE) binding protein 3	49					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|RNA binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(10)|ovary(2)|urinary_tract(2)	21				OV - Ovarian serous cystadenocarcinoma(145;0.000279)		GTGGACCCCTCAGTATATGGA	0.413000													41	48					0	0	1	0	0
MMRN1	22915	broad.mit.edu	37	4	90816728	90816728	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr4:90816728C>T	ENST00000394980.1	+	2	925	c.606C>T	c.(604-606)ttC>ttT	p.F202F	MMRN1_ENST00000264790.2_Silent_p.F202F|MMRN1_ENST00000394981.1_Silent_p.F168F			Q13201	MMRN1_HUMAN	multimerin 1	202					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		AATCAAATTTCGAAACAACTA	0.443000													5	18					0	0	1	0	0
UQCRC1	7384	broad.mit.edu	37	3	48638500	48638500	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:48638500C>T	ENST00000203407.5	-	8	1290	c.874G>A	c.(874-876)Gag>Aag	p.E292K		NM_003365.2	NP_003356.2	P31930	QCR1_HUMAN	ubiquinol-cytochrome c reductase core protein I	292					aerobic respiration|proteolysis		metalloendopeptidase activity|ubiquinol-cytochrome-c reductase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)	Atovaquone(DB01117)	CCAGGACCCTCTACTGCAATG	0.577000													9	18					0	0	1	0	0
RDH11	51109	broad.mit.edu	37	14	68159213	68159213	+	Silent	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr14:68159213C>G	ENST00000381346.4	-	3	401	c.291G>C	c.(289-291)cgG>cgC	p.R97R	RDH11_ENST00000428130.2_Silent_p.R97R|RDH11_ENST00000553384.1_Silent_p.R84R	NM_001252650.1|NM_016026.3	NP_001239579.1|NP_057110.3	Q8TC12	RDH11_HUMAN	retinol dehydrogenase 11 (all-trans/9-cis/11-cis)	97					retinol metabolic process|steroid metabolic process	endoplasmic reticulum membrane|integral to membrane	binding|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(3)|ovary(1)	12				all cancers(60;0.00047)|OV - Ovarian serous cystadenocarcinoma(108;0.00206)|BRCA - Breast invasive adenocarcinoma(234;0.00924)	Vitamin A(DB00162)	GGTCCAGTTTCCGCACCAACA	0.493000													34	108					0	0	1	0	0
WIZ	58525	broad.mit.edu	37	19	15536436	15536436	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:15536436C>T	ENST00000389282.4	-	7	4009	c.3796G>A	c.(3796-3798)Gac>Aac	p.D1266N	WIZ_ENST00000599686.3_Missense_Mutation_p.D450N|WIZ_ENST00000263381.7_Missense_Mutation_p.D409N|WIZ_ENST00000545156.1_Missense_Mutation_p.D580N|WIZ_ENST00000599910.2_Missense_Mutation_p.D583N			O95785	WIZ_HUMAN	widely interspaced zinc finger motifs	1266						nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	24						CGCAGTGTGTCGATGGGCGAA	0.637000													8	24					0	0	1	0	0
SLFN5	162394	broad.mit.edu	37	17	33585826	33585826	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:33585826G>C	ENST00000299977.4	+	2	265	c.117G>C	c.(115-117)caG>caC	p.Q39H	SLFN5_ENST00000542451.1_Missense_Mutation_p.Q39H|SLFN5_ENST00000592325.1_Missense_Mutation_p.Q39H	NM_144975.3	NP_659412.3	Q08AF3	SLFN5_HUMAN	schlafen family member 5	39					cell differentiation		ATP binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(8)|liver(2)|lung(6)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	34		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		GGGAGAAACAGAATGAAATCA	0.483000													89	40					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32783746	32783746	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr13:32783746G>A	ENST00000380250.3	+	33	4796	c.4300G>A	c.(4300-4302)Gaa>Aaa	p.E1434K		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	1434					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TCCTGGGCCAGAAATGGAAAA	0.433000													17	49					0	0	1	0	0
BRMS1	25855	broad.mit.edu	37	11	66108691	66108691	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:66108691C>T	ENST00000359957.3	-	4	504	c.344G>A	c.(343-345)cGc>cAc	p.R115H	BRMS1_ENST00000425825.2_Missense_Mutation_p.R115H	NM_015399.3	NP_056214.1	Q9HCU9	BRMS1_HUMAN	breast cancer metastasis suppressor 1	115					apoptosis|negative regulation of anti-apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of anoikis|positive regulation of protein deacetylation|transcription, DNA-dependent	cytoplasm|nucleus	NF-kappaB binding			large_intestine(1)|liver(1)|lung(1)|prostate(1)|skin(1)	5						CACCTGAATGCGAATCTTGAG	0.647000													11	26					0	0	1	0	0
RRAS2	22800	broad.mit.edu	37	11	14380319	14380319	+	Missense_Mutation	SNP	T	T	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:14380319T>A	ENST00000545643.1	-	1	411	c.98A>T	c.(97-99)cAg>cTg	p.Q33L	RRAS2_ENST00000529237.1_Intron|RRAS2_ENST00000256196.4_Missense_Mutation_p.Q33L|RRAS2_ENST00000537760.1_Intron	NM_012250.5	NP_036382.2	P62070	RRAS2_HUMAN	related RAS viral (r-ras) oncogene homolog 2	33						endoplasmic reticulum|plasma membrane	GTP binding|GTPase activity|protein binding			breast(3)|endometrium(4)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	12				Epithelial(150;0.203)		CTGGATGAACTGGATGGTGAG	0.791000													3	4					0	0	1	0	0
G6PC	2538	broad.mit.edu	37	17	41053035	41053035	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:41053035C>A	ENST00000253801.2	+	1	221	c.142C>A	c.(142-144)Ccc>Acc	p.P48T	G6PC_ENST00000592383.1_Missense_Mutation_p.P48T|G6PC_ENST00000585489.1_Missense_Mutation_p.P48T	NM_000151.3	NP_000142.2	P35575	G6PC_HUMAN	glucose-6-phosphatase, catalytic subunit	48					gluconeogenesis|glucose homeostasis|transmembrane transport	integral to endoplasmic reticulum membrane	glucose-6-phosphatase activity|phosphate binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)	23		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.113)		CGTCCTCTTCCCCATCTGGTT	0.493000													5	122					0.000157383	0.000160427	1	1	0
WIZ	58525	broad.mit.edu	37	19	15535434	15535434	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:15535434C>G	ENST00000389282.4	-	8	4803	c.4590G>C	c.(4588-4590)caG>caC	p.Q1530H	WIZ_ENST00000599686.3_Missense_Mutation_p.Q714H|WIZ_ENST00000263381.7_Missense_Mutation_p.Q673H|WIZ_ENST00000545156.1_Missense_Mutation_p.Q844H|WIZ_ENST00000599910.2_Missense_Mutation_p.Q847H			O95785	WIZ_HUMAN	widely interspaced zinc finger motifs	1530						nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	24						TGTTGATGTTCTGCCGCTGGT	0.706000													8	7					0	0	1	0	0
DCUN1D1	54165	broad.mit.edu	37	3	182681832	182681832	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:182681832G>C	ENST00000292782.4	-	3	379	c.226C>G	c.(226-228)Caa>Gaa	p.Q76E	DCUN1D1_ENST00000469954.1_Missense_Mutation_p.Q61E	NM_020640.2	NP_065691.2	Q96GG9	DCNL1_HUMAN	DCN1, defective in cullin neddylation 1, domain containing 1	76	DCUN1.					ubiquitin ligase complex	protein binding			endometrium(2)|large_intestine(4)|lung(8)|ovary(1)	15	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;2.54e-44)|Epithelial(37;4.71e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			TTCTCATCTTGAGGGTCTTTA	0.338000													9	45					0	0	1	0	0
WIZ	58525	broad.mit.edu	37	19	15535532	15535532	+	Nonsense_Mutation	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:15535532C>A	ENST00000389282.4	-	8	4705	c.4492G>T	c.(4492-4494)Gag>Tag	p.E1498*	WIZ_ENST00000599686.3_Nonsense_Mutation_p.E682*|WIZ_ENST00000263381.7_Nonsense_Mutation_p.E641*|WIZ_ENST00000545156.1_Nonsense_Mutation_p.E812*|WIZ_ENST00000599910.2_Nonsense_Mutation_p.E815*			O95785	WIZ_HUMAN	widely interspaced zinc finger motifs	1498						nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	24						GGCCCTGGCTCCCCTCCGGCA	0.746000													5	6					0.00116845	0.00118287	1	1	0
ITFG2	55846	broad.mit.edu	37	12	2932046	2932046	+	Silent	SNP	A	A	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:2932046A>G	ENST00000228799.2	+	10	1174	c.1035A>G	c.(1033-1035)caA>caG	p.Q345Q	ITFG2_ENST00000542548.1_Silent_p.Q233Q|ITFG2_ENST00000419778.2_Silent_p.Q168Q	NM_018463.3	NP_060933.3	Q969R8	ITFG2_HUMAN	integrin alpha FG-GAP repeat containing 2	345										central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(13)|upper_aerodigestive_tract(2)	19			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			TCCGCTTCCAAGTGGATGAAA	0.542000													22	25					0	0	1	0	0
RAI14	26064	broad.mit.edu	37	5	34823482	34823482	+	Nonsense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:34823482C>G	ENST00000265109.3	+	15	1822	c.1535C>G	c.(1534-1536)tCa>tGa	p.S512*	RAI14_ENST00000515799.1_Nonsense_Mutation_p.S515*|RAI14_ENST00000397449.1_Nonsense_Mutation_p.S505*|RAI14_ENST00000428746.2_Nonsense_Mutation_p.S512*|RAI14_ENST00000506376.1_Nonsense_Mutation_p.S504*|RAI14_ENST00000503673.1_Nonsense_Mutation_p.S512*|RAI14_ENST00000512629.1_Nonsense_Mutation_p.S483*	NM_001145522.1|NM_015577.2	NP_001138994.1|NP_056392.2	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14	512						cell cortex|cytoskeleton	protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(19)|lung(22)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(31;0.000191)					GGTCTTGTCTCACCTGAAAGC	0.428000													15	38					0	0	1	0	0
NSUN7	79730	broad.mit.edu	37	4	40752914	40752914	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr4:40752914C>G	ENST00000381782.2	+	2	699	c.204C>G	c.(202-204)atC>atG	p.I68M	NSUN7_ENST00000316607.5_Missense_Mutation_p.I68M	NM_024677.4	NP_078953			NOP2/Sun domain family, member 7											NS(1)|autonomic_ganglia(1)|cervix(1)|large_intestine(1)|lung(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	12						AAGTCTTAATCAAGTATGGGA	0.483000													22	53					0	0	1	0	0
ITIH4	3700	broad.mit.edu	37	3	52854782	52854782	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:52854782C>A	ENST00000266041.4	-	13	1795	c.1699G>T	c.(1699-1701)Gat>Tat	p.D567Y	ITIH4_ENST00000346281.5_Missense_Mutation_p.D567Y|ITIH4_ENST00000406595.1_Missense_Mutation_p.D567Y|ITIH4_ENST00000434759.3_Missense_Mutation_p.D479Y|RP5-966M1.6_ENST00000468472.1_3'UTR|ITIH4_ENST00000485816.1_Missense_Mutation_p.D567Y	NM_002218.4	NP_002209.2	Q14624	ITIH4_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 4	567					acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		GCCTGCTGATCAGCATCGGAT	0.532000											OREG0015616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	44					1.12685e-05	1.16147e-05	1	1	0
OR2M4	26245	broad.mit.edu	37	1	248403030	248403030	+	Missense_Mutation	SNP	C	C	T	rs144697226	byFrequency	TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:248403030C>T	ENST00000306687.1	+	1	800	c.800C>T	c.(799-801)aCg>aTg	p.T267M		NM_017504.1	NP_059974.1	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M, member 4	267					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T267M(2)		NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(27)|skin(3)|upper_aerodigestive_tract(2)	50	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TCTAAACATACGCCAGACCAG	0.517000													21	19					0	0	1	0	0
COL19A1	1310	broad.mit.edu	37	6	70852696	70852696	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:70852696G>A	ENST00000322773.4	+	23	1712	c.1610G>A	c.(1609-1611)gGa>gAa	p.G537E	COL19A1_ENST00000393344.1_Missense_Mutation_p.G159E	NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	537	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						GGACCCAGAGGACCGCCAGGA	0.358000													8	32					0	0	1	0	0
HMHA1	23526	broad.mit.edu	37	19	1074147	1074147	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:1074147G>A	ENST00000313093.2	+	7	1066	c.835G>A	c.(835-837)Gag>Aag	p.E279K	HMHA1_ENST00000590214.1_Missense_Mutation_p.E306K|HMHA1_ENST00000586866.1_Missense_Mutation_p.E283K|HMHA1_ENST00000543365.1_Missense_Mutation_p.E162K|HMHA1_ENST00000536472.1_Missense_Mutation_p.E119K|HMHA1_ENST00000539243.2_Missense_Mutation_p.E295K	NM_012292.3	NP_036424.2	Q92619	HMHA1_HUMAN	histocompatibility (minor) HA-1	279					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(7)|ovary(1)|prostate(2)	16		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACAGCGCTGTGAGGGGGGCGT	0.662000													15	27					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108489812	108489812	+	Missense_Mutation	SNP	A	A	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:108489812A>T	ENST00000263054.6	-	6	1027	c.1020T>A	c.(1018-1020)gaT>gaA	p.D340E	SORCS1_ENST00000344440.6_Missense_Mutation_p.D340E	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	340						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		ACTTACGACCATCCACAGTTC	0.378000													10	64					0	0	1	0	0
TSPO	706	broad.mit.edu	37	22	43557148	43557148	+	Silent	SNP	G	G	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr22:43557148G>T	ENST00000329563.4	+	3	499	c.273G>T	c.(271-273)ctG>ctT	p.L91L	TSPO_ENST00000337554.3_Silent_p.L91L|TSPO_ENST00000396265.3_5'UTR|TSPO_ENST00000583777.1_5'UTR	NM_001256530.1|NM_001256531.1	NP_001243459.1|NP_001243460.1	B1AH88	TSPOB_HUMAN	translocator protein (18kDa)	67										endometrium(1)|prostate(1)	2		Ovarian(80;0.0694)				AGCTGGCCCTGAACTGGGCAT	0.602000													4	23					0.150653	0.150653	1	1	0
CLMP	79827	broad.mit.edu	37	11	122945447	122945447	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:122945447C>G	ENST00000448775.2	-	6	1124	c.784G>C	c.(784-786)Gaa>Caa	p.E262Q	CLMP_ENST00000530371.1_5'UTR	NM_024769.2	NP_079045.1	Q9H6B4	CLMP_HUMAN	CXADR-like membrane protein	262						integral to membrane|tight junction				endometrium(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	14						TCATATCTTTCTTTGTCTTTC	0.483000													92	94					0	0	1	0	0
BRD9	65980	broad.mit.edu	37	5	865589	865589	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:865589G>A	ENST00000323510.4	-	12	1344	c.1345C>T	c.(1345-1347)Cgg>Tgg	p.R449W	BRD9_ENST00000467963.1_Missense_Mutation_p.R545W|BRD9_ENST00000483173.1_Missense_Mutation_p.R492W|BRD9_ENST00000388890.4_Missense_Mutation_p.R429W			Q9H8M2	BRD9_HUMAN	bromodomain containing 9	545							nucleic acid binding	p.R449W(1)|p.R545W(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|pancreas(1)|prostate(3)	29			Epithelial(17;0.00202)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00815)|Lung(60;0.185)			GACGACGGCCGAGAGCCGCCG	0.652000													66	78					0	0	1	0	0
KIAA0556	23247	broad.mit.edu	37	16	27763243	27763243	+	Silent	SNP	C	C	A	rs139172052	byFrequency	TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr16:27763243C>A	ENST00000261588.4	+	17	3569	c.3550C>A	c.(3550-3552)Cgg>Agg	p.R1184R		NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	1184								p.R1184W(1)		breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						GGCTGATGAACGGGTAGGACT	0.607000													5	37					0.000602214	0.000610487	1	1	0
MAP1A	4130	broad.mit.edu	37	15	43817838	43817838	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:43817838G>C	ENST00000382031.1	+	5	4912	c.4881G>C	c.(4879-4881)caG>caC	p.Q1627H	MAP1A_ENST00000399453.1_Missense_Mutation_p.Q1389H|MAP1A_ENST00000300231.5_Missense_Mutation_p.Q1389H			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1389						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CCATCTATCAGAAAGATGAGG	0.453000													7	19					0	0	1	0	0
WIZ	58525	broad.mit.edu	37	19	15536413	15536413	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:15536413C>G	ENST00000389282.4	-	7	4032	c.3819G>C	c.(3817-3819)aaG>aaC	p.K1273N	WIZ_ENST00000599686.3_Missense_Mutation_p.K457N|WIZ_ENST00000263381.7_Missense_Mutation_p.K416N|WIZ_ENST00000545156.1_Missense_Mutation_p.K587N|WIZ_ENST00000599910.2_Missense_Mutation_p.K590N			O95785	WIZ_HUMAN	widely interspaced zinc finger motifs	1273						nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	24						TGGACTTCTTCTTGAGGATCT	0.662000													8	15					0	0	1	0	0
SPATA2	9825	broad.mit.edu	37	20	48522903	48522903	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr20:48522903C>G	ENST00000422556.1	-	3	1165	c.816G>C	c.(814-816)ttG>ttC	p.L272F	SPATA2_ENST00000543716.1_Missense_Mutation_p.L135F|SPATA2_ENST00000289431.5_Missense_Mutation_p.L272F	NM_001135773.1	NP_001129245.1	Q9UM82	SPAT2_HUMAN	spermatogenesis associated 2	272					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus				central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(1)	20	Hepatocellular(150;0.133)		BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			TCCGAAGACTCAATGAGGCCT	0.617000													44	100					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71492562	71492562	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:71492562C>A	ENST00000296755.7	+	5	3678	c.3380C>A	c.(3379-3381)tCc>tAc	p.S1127Y		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1127						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		ATTGAGATATCCAGTGAGCCC	0.522000													10	17					1.08611e-07	1.13856e-07	1	1	0
DUSP7	1849	broad.mit.edu	37	3	52088320	52088320	+	Silent	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:52088320C>G	ENST00000495880.1	-	2	771	c.588G>C	c.(586-588)ccG>ccC	p.P196P	DUSP7_ENST00000296483.6_Silent_p.P145P			Q16829	DUS7_HUMAN	dual specificity phosphatase 7	196	Ser-rich.				inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein binding|protein tyrosine phosphatase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(1)	17				BRCA - Breast invasive adenocarcinoma(193;5.14e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GCGAGCTGCTCGGCGAGGAAG	0.632000													15	32					0	0	1	0	0
ASXL1	171023	broad.mit.edu	37	20	31021233	31021233	+	Missense_Mutation	SNP	G	G	T	rs143719307		TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr20:31021233G>T	ENST00000375687.4	+	12	1656	c.1232G>T	c.(1231-1233)cGc>cTc	p.R411L	ASXL1_ENST00000306058.5_Missense_Mutation_p.R406L	NM_015338.5	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 (Drosophila)	411					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(655)|kidney(5)|large_intestine(18)|liver(1)|lung(27)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	722						TTTAAGAAACGCTCTCGGCCA	0.512000			"""F, N, Mis"""		"""MDS, CMML"""								15	85					1.49906e-05	1.54082e-05	1	1	0
C11orf88	399949	broad.mit.edu	37	11	111405136	111405136	+	Splice_Site	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:111405136G>A	ENST00000529167.1	+	6	480		c.e6-1		C11orf88_ENST00000375618.4_Splice_Site|C11orf88_ENST00000332814.6_Splice_Site			Q6PI97	CK088_HUMAN	chromosome 11 open reading frame 88											endometrium(1)|large_intestine(3)|lung(2)	6						TTTTGTTTCAGAAAGAACTGA	0.303000													24	28					0	0	1	0	0
PDGFD	80310	broad.mit.edu	37	11	103870931	103870931	+	Missense_Mutation	SNP	T	T	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:103870931T>A	ENST00000302251.5	-	2	610	c.159A>T	c.(157-159)aaA>aaT	p.K53N	PDGFD_ENST00000393158.2_Missense_Mutation_p.K59N	NM_025208.4|NM_033135.3	NP_079484.1|NP_149126.1	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D	59	CUB.				positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)	23		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		AGCCGTTTCCTTTCACCTGGA	0.483000													23	78					0	0	1	0	0
DHTKD1	55526	broad.mit.edu	37	10	12155060	12155060	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:12155060C>T	ENST00000263035.4	+	13	2378	c.2316C>T	c.(2314-2316)ctC>ctT	p.L772L		NM_018706.5	NP_061176	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain containing 1	772					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(1)	44		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			TACTCAGGCTCCCGGTAAGCA	0.403000													39	32					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85611688	85611688	+	Nonsense_Mutation	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr4:85611688C>A	ENST00000322366.6	-	60	9690	c.9283G>T	c.(9283-9285)Gaa>Taa	p.E3095*	WDFY3_ENST00000295888.4_Nonsense_Mutation_p.E3112*			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	3112						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TTGGCCTTTTCTTTGGAGGTG	0.522000													12	43					0.00010058	0.000102667	1	1	0
FAM216B	144809	broad.mit.edu	37	13	43362835	43362835	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr13:43362835C>T	ENST00000537894.1	+	4	452	c.329C>T	c.(328-330)tCa>tTa	p.S110L	FAM216B_ENST00000313851.1_Missense_Mutation_p.S110L	NM_182508.2	NP_872314.1	Q8N7L0	CM030_HUMAN	family with sequence similarity 216, member B	110																	CGGAAAACTTCAGCCATGACA	0.483000													11	49					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152326408	152326408	+	Nonsense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:152326408G>C	ENST00000388718.5	-	3	3926	c.3854C>G	c.(3853-3855)tCa>tGa	p.S1285*	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1285	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGTCTGTGTGAGACCTTTGA	0.473000													49	283					0	0	1	0	0
ANLN	54443	broad.mit.edu	37	7	36447536	36447536	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:36447536C>T	ENST00000265748.2	+	5	1288	c.1067C>T	c.(1066-1068)tCt>tTt	p.S356F	ANLN_ENST00000396068.2_Missense_Mutation_p.S356F|ANLN_ENST00000495714.1_3'UTR	NM_018685.2	NP_061155.2	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	356	Interaction with F-actin.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			breast(2)|endometrium(5)|kidney(5)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(2)	45						TGTCTGCAATCTCAATCTAAA	0.338000													16	45					0	0	1	0	0
HSPA8	3312	broad.mit.edu	37	11	122931934	122931934	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:122931934C>T	ENST00000534624.1	-	2	375	c.99G>A	c.(97-99)caG>caA	p.Q33Q	HSPA8_ENST00000526110.1_Silent_p.Q33Q|HSPA8_ENST00000532636.1_Silent_p.Q33Q|HSPA8_ENST00000453788.2_Silent_p.Q33Q|HSPA8_ENST00000227378.3_Silent_p.Q33Q|HSPA8_ENST00000533540.1_Silent_p.Q33Q	NM_006597.4	NP_006588.1	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8	33					cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding			breast(1)|central_nervous_system(7)|endometrium(1)|kidney(9)|large_intestine(4)|lung(13)|upper_aerodigestive_tract(1)	36		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TTCGGTTTCCCTGATCATTGG	0.498000													27	30					0	0	1	0	0
UMPS	7372	broad.mit.edu	37	3	124456735	124456735	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:124456735C>T	ENST00000232607.2	+	3	737	c.631C>T	c.(631-633)Cat>Tat	p.H211Y	UMPS_ENST00000538242.1_Missense_Mutation_p.H33Y|UMPS_ENST00000498715.1_3'UTR|UMPS_ENST00000536109.1_Missense_Mutation_p.H119Y|UMPS_ENST00000413078.2_Missense_Mutation_p.H33Y	NM_000373.3	NP_000364.1	P11172	UMPS_HUMAN	uridine monophosphate synthetase	211	OPRTase.				'de novo' pyrimidine base biosynthetic process|'de novo' UMP biosynthetic process|pyrimidine nucleoside biosynthetic process	cytosol|nucleus	orotate phosphoribosyltransferase activity|orotidine-5'-phosphate decarboxylase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	16				GBM - Glioblastoma multiforme(114;0.146)		GGCAGCGAATCATAATGGTTC	0.478000													4	40					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	79432495	79432495	+	Silent	SNP	T	T	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr14:79432495T>C	ENST00000554719.1	+	9	1895	c.1404T>C	c.(1402-1404)aaT>aaC	p.N468N	NRXN3_ENST00000335750.5_Silent_p.N468N	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	0					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		TCATGTTTAATGGCCTTCTCT	0.463000													11	28					0	0	1	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587576	43587576	+	RNA	SNP	A	A	G	rs145439557	by1000genomes	TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:43587576A>G	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							tctgaaaagaaaagaaaaaaa	0.428000													8	44					0	0	1	0	0
PET112	5188	broad.mit.edu	37	4	152682084	152682084	+	Silent	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr4:152682084G>A	ENST00000263985.6	-	1	91	c.51C>T	c.(49-51)ttC>ttT	p.F17F	PET112_ENST00000515812.1_Silent_p.F17F|PET112_ENST00000508611.1_Silent_p.F17F|PET112_ENST00000512306.1_Silent_p.F17F	NM_004564.2	NP_004555.1	O75879	GATB_HUMAN	PET112 homolog (yeast)	17						mitochondrion	ATP binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor|translation factor activity, nucleic acid binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	23					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CAACCCGGGCGAAAGCCCAAC	0.637000													29	22					0	0	1	0	0
CLK1	1195	broad.mit.edu	37	2	201722761	201722761	+	Silent	SNP	A	A	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:201722761A>G	ENST00000434813.2	-	6	1060	c.726T>C	c.(724-726)tgT>tgC	p.C242C	CLK1_ENST00000321356.4_Silent_p.C200C|CLK1_ENST00000409769.2_Silent_p.C23C	NM_001162407.1	NP_001155879.1	P49759	CLK1_HUMAN	CDC-like kinase 1	200	Protein kinase.				cell proliferation	nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			NS(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(12)|ovary(1)|pancreas(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	33						GAGCAGCTTCACAGTATCTAT	0.378000													26	57					0	0	1	0	0
SQLE	6713	broad.mit.edu	37	8	126011857	126011857	+	Nonsense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:126011857C>G	ENST00000265896.5	+	1	1110	c.212C>G	c.(211-213)tCa>tGa	p.S71*	SQLE_ENST00000523430.1_Intron	NM_003129.3	NP_003120.2	Q14534	ERG1_HUMAN	squalene epoxidase	71					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome	flavin adenine dinucleotide binding|squalene monooxygenase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)	14	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)		Butenafine(DB01091)|Naftifine(DB00735)|Terbinafine(DB00857)	GATATTCTCTCAGGCCTGCCT	0.602000													6	16					0	0	1	0	0
BIRC2	329	broad.mit.edu	37	11	102221266	102221266	+	Silent	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:102221266C>A	ENST00000227758.2	+	2	2080	c.681C>A	c.(679-681)ctC>ctA	p.L227L	BIRC2_ENST00000532672.1_Silent_p.L206L|BIRC2_ENST00000530675.1_Silent_p.L178L|BIRC2_ENST00000527910.1_3'UTR	NM_001166.4|NM_001256163.1	NP_001157.1|NP_001243092.1	Q13490	BIRC2_HUMAN	baculoviral IAP repeat containing 2	227					cell surface receptor linked signaling pathway|cellular component disassembly involved in apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	CD40 receptor complex|cytosol|internal side of plasma membrane	protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|liver(2)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|Epithelial(9;0.11)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0144)		GTGGGAAGCTCAGTAACTGGG	0.438000													28	101					2.12542e-12	2.25692e-12	1	1	0
GCC2	9648	broad.mit.edu	37	2	109091990	109091990	+	Splice_Site	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:109091990G>C	ENST00000309863.6	+	8	3574		c.e8-1			NM_181453.3	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain containing 2						Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			breast(8)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	54						TCTATTTTTAGAAAATCTGGA	0.294000													3	3					0	0	1	0	0
SHANK3	85358	broad.mit.edu	37	22	51143229	51143229	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr22:51143229C>T	ENST00000414786.2	+	15	2020	c.1793C>T	c.(1792-1794)tCg>tTg	p.S598L	SHANK3_ENST00000445220.2_Missense_Mutation_p.S613L|SHANK3_ENST00000262795.3_Missense_Mutation_p.S628L			F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	628										central_nervous_system(1)|endometrium(1)|kidney(1)|lung(5)	8		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		TATCTCGAGTCGGTGGACGTG	0.667000													7	17					0	0	1	0	0
PHACTR3	116154	broad.mit.edu	37	20	58318241	58318241	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr20:58318241C>T	ENST00000371015.1	+	2	665	c.198C>T	c.(196-198)agC>agT	p.S66S	PHACTR3_ENST00000359926.3_Silent_p.S63S|PHACTR3_ENST00000395636.2_Silent_p.S25S|PHACTR3_ENST00000541461.1_Silent_p.S25S|PHACTR3_ENST00000355648.4_Silent_p.S25S|PHACTR3_ENST00000395639.4_Silent_p.S25S|PHACTR3_ENST00000361300.4_Silent_p.S25S	NM_001281507.1|NM_080672.3	NP_001268436.1|NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	66						nuclear matrix	actin binding|protein phosphatase inhibitor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			GGAGGAACAGCAAACTGGCCA	0.527000													13	88					0	0	1	0	0
CADM1	23705	broad.mit.edu	37	11	115047243	115047243	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:115047243G>A	ENST00000452722.3	-	10	1300	c.1280C>T	c.(1279-1281)gCa>gTa	p.A427V	CADM1_ENST00000542447.2_Missense_Mutation_p.A399V|CADM1_ENST00000537058.1_Missense_Mutation_p.A438V|CADM1_ENST00000537140.1_Intron|CADM1_ENST00000536727.1_Missense_Mutation_p.A428V|CADM1_ENST00000331581.6_Missense_Mutation_p.A456V	NM_014333.3	NP_055148.3	Q9BY67	CADM1_HUMAN	cell adhesion molecule 1						adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(9)|ovary(2)|skin(1)	32	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		TCCTCCTTCTGCATTGATTAT	0.443000													27	91					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61865721	61865721	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr10:61865721C>T	ENST00000280772.2	-	28	3461	c.3270G>A	c.(3268-3270)gaG>gaA	p.E1090E	ANK3_ENST00000503366.1_Silent_p.E1091E|ANK3_ENST00000355288.2_Silent_p.E224E|ANK3_ENST00000373827.2_Silent_p.E1084E	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)						establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CAAACTGATGCTCCTTCCAAG	0.423000													10	20					0	0	1	0	0
CYP7A1	1581	broad.mit.edu	37	8	59410823	59410823	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr8:59410823C>A	ENST00000301645.3	-	2	423	c.286G>T	c.(286-288)Gat>Tat	p.D96Y		NM_000780.3	NP_000771.2	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A, polypeptide 1	96					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(1)|urinary_tract(1)	34		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				TTTTTCCAATCAAAATATTTT	0.338000									Neonatal Giant Cell Hepatitis				13	53					0.00010058	0.000102667	1	1	0
IGSF3	3321	broad.mit.edu	37	1	117122246	117122246	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:117122246C>T	ENST00000369486.3	-	10	3867	c.3102G>A	c.(3100-3102)ctG>ctA	p.L1034L	IGSF3_ENST00000318837.6_Silent_p.L1054L|IGSF3_ENST00000369483.1_Silent_p.L1054L	NM_001007237.1	NP_001007238.1	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3	1034	Ig-like C2-type 8.					integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	62	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		GGCCCACGCTCAGCAGGGCCG	0.657000													4	18					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140208823	140208823	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:140208823G>A	ENST00000529310.1	+	1	1261	c.1147G>A	c.(1147-1149)Ggg>Agg	p.G383R	PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000527624.1_Missense_Mutation_p.G383R|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529619.1_Intron	NM_018909.2|NM_031848.2|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGTGCCAACGGGCAGGTGAA	0.537000													36	136					0	0	1	0	0
BTNL9	153579	broad.mit.edu	37	5	180486730	180486730	+	Silent	SNP	C	C	T	rs138408414	byFrequency	TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:180486730C>T	ENST00000327705.9	+	11	1707	c.1476C>T	c.(1474-1476)gaC>gaT	p.D492D	BTNL9_ENST00000376842.3_Silent_p.D493D	NM_152547.4	NP_689760.2	Q6UXG8	BTNL9_HUMAN	butyrophilin-like 9	492	B30.2/SPRY.					integral to membrane				breast(2)|central_nervous_system(1)|kidney(4)|large_intestine(1)|lung(10)|ovary(1)	19	all_cancers(89;2.45e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGGCCCACGACGGCGGCGAAC	0.637000													6	14					0	0	1	0	0
RIMS1	22999	broad.mit.edu	37	6	72952065	72952065	+	Missense_Mutation	SNP	A	A	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:72952065A>G	ENST00000264839.7	+	10	2006	c.2006A>G	c.(2005-2007)aAt>aGt	p.N669S	RIMS1_ENST00000491071.2_Missense_Mutation_p.N669S|RIMS1_ENST00000521978.1_Missense_Mutation_p.N669S|RIMS1_ENST00000348717.5_Missense_Mutation_p.N669S|RIMS1_ENST00000518273.1_Missense_Mutation_p.N669S|RIMS1_ENST00000520567.1_Missense_Mutation_p.N669S|RIMS1_ENST00000522291.1_Missense_Mutation_p.N669S|RIMS1_ENST00000523963.1_Missense_Mutation_p.N143S|RIMS1_ENST00000517827.1_Missense_Mutation_p.N128S|RIMS1_ENST00000517960.1_Missense_Mutation_p.N669S|RIMS1_ENST00000401910.3_Missense_Mutation_p.N143S|RIMS1_ENST00000425662.2_Missense_Mutation_p.N62S			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	669	PDZ.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				GGAGCTACAAATGAAGAAGTT	0.308000													3	3					0	0	1	0	0
NLN	57486	broad.mit.edu	37	5	65077246	65077246	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:65077246G>C	ENST00000380985.5	+	6	998	c.820G>C	c.(820-822)Gag>Cag	p.E274Q	NLN_ENST00000502464.1_Missense_Mutation_p.E170Q	NM_020726.4	NP_065777.1	Q9BYT8	NEUL_HUMAN	neurolysin (metallopeptidase M3 family)	274					proteolysis	mitochondrial intermembrane space	metal ion binding|metalloendopeptidase activity			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	26		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0743)|Lung(70;0.00616)		AAGGTGCAAAGAGGTATTATA	0.328000													6	38					0	0	1	0	0
CLHC1	130162	broad.mit.edu	37	2	55402958	55402958	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr2:55402958C>T	ENST00000401408.1	-	13	2074	c.1729G>A	c.(1729-1731)Gca>Aca	p.A577T	CLHC1_ENST00000406076.1_Missense_Mutation_p.A455T|CLHC1_ENST00000494539.1_5'UTR|CLHC1_ENST00000406437.2_Missense_Mutation_p.A128T|CLHC1_ENST00000407122.1_Missense_Mutation_p.A577T	NM_152385.2	NP_689598.2			clathrin heavy chain linker domain containing 1																		AGGTTGACTGCGTCATCCTCT	0.383000													20	32					0	0	1	0	0
PDIA3	2923	broad.mit.edu	37	15	44048938	44048938	+	Missense_Mutation	SNP	G	G	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr15:44048938G>T	ENST00000300289.5	+	3	486	c.338G>T	c.(337-339)gGt>gTt	p.G113V	PDIA3_ENST00000538521.1_Missense_Mutation_p.G93V	NM_005313.4	NP_005304.3	P30101	PDIA3_HUMAN	protein disulfide isomerase family A, member 3	113	Thioredoxin 1.				cell redox homeostasis|glycerol ether metabolic process|post-translational protein modification|protein folding|protein import into nucleus|protein N-linked glycosylation via asparagine|protein retention in ER lumen|signal transduction	endoplasmic reticulum lumen|melanosome	cysteine-type endopeptidase activity|electron carrier activity|phospholipase C activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(9)|ovary(2)|skin(1)	17		all_cancers(109;2.61e-15)|all_epithelial(112;1.12e-12)|Lung NSC(122;2.17e-08)|all_lung(180;2.45e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.48e-07)		GAAGAAGCAGGTGCTTATGAT	0.388000													12	70					3.07112e-06	3.19223e-06	1	1	0
GGT5	2687	broad.mit.edu	37	22	24621044	24621044	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr22:24621044C>G	ENST00000327365.4	-	11	1950	c.1534G>C	c.(1534-1536)Gac>Cac	p.D512H	GGT5_ENST00000418439.2_Missense_Mutation_p.D436H|GGT5_ENST00000263112.7_Missense_Mutation_p.D480H|GGT5_ENST00000398292.3_Missense_Mutation_p.D513H	NM_001099781.1|NM_004121.2	NP_001093251.1|NP_004112.2	P36269	GGT5_HUMAN	gamma-glutamyltransferase 5	512					glutathione biosynthetic process|hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	integral to membrane|plasma membrane	acyltransferase activity|gamma-glutamyltransferase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(3)|skin(3)	28						GCTCTCAGGTCAAAGCCAAGC	0.602000													4	4					0	0	1	0	0
UPK1B	7348	broad.mit.edu	37	3	118906762	118906762	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:118906762C>T	ENST00000264234.3	+	3	359	c.210C>T	c.(208-210)ttC>ttT	p.F70F	UPK1B_ENST00000497685.1_5'UTR|UPK1B_ENST00000460625.1_Silent_p.F70F	NM_006952.3	NP_008883.2	O75841	UPK1B_HUMAN	uroplakin 1B	70					epithelial cell differentiation	integral to membrane	structural molecule activity			breast(1)|endometrium(3)|large_intestine(2)|lung(6)|pancreas(1)|skin(1)	14				GBM - Glioblastoma multiforme(114;0.222)		TCTGCCTCTTCTGCCTGTCTG	0.507000													37	77					0	0	1	0	0
INTS7	25896	broad.mit.edu	37	1	212115287	212115287	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:212115287C>A	ENST00000366994.3	-	20	2872	c.2768G>T	c.(2767-2769)aGa>aTa	p.R923I	INTS7_ENST00000366993.3_Missense_Mutation_p.R909I|INTS7_ENST00000440600.2_Missense_Mutation_p.R874I|INTS7_ENST00000469606.1_5'UTR|INTS7_ENST00000366992.3_Missense_Mutation_p.R903I	NM_001199811.1|NM_001199812.1|NM_015434.3	NP_001186740.1|NP_001186741.1|NP_056249.1	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	923					snRNA processing	integrator complex	protein binding			NS(1)|breast(1)|kidney(1)|large_intestine(8)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		TATGGTAGTTCTGGGACCAGT	0.443000													24	97					1.55469e-16	1.67989e-16	1	1	0
ZNF626	199777	broad.mit.edu	37	19	20807108	20807108	+	Silent	SNP	T	T	C			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:20807108T>C	ENST00000601440.1	-	4	1721	c.1575A>G	c.(1573-1575)ctA>ctG	p.L525L	CTC-513N18.7_ENST00000595094.1_lincRNA	NM_001076675.2	NP_001070143.1	Q68DY1	ZN626_HUMAN	zinc finger protein 626	525					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|lung(3)|skin(1)	6						ATCTTATGTGTAGTAAGGTGT	0.358000													6	63					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155242291	155242291	+	Missense_Mutation	SNP	T	T	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr4:155242291T>G	ENST00000357232.4	-	14	2894	c.2895A>C	c.(2893-2895)aaA>aaC	p.K965N		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2		Cadherin 8.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		AGCTCATTATTTTTGTGGGCT	0.323000													18	64					0	0	1	0	0
NEURL4	84461	broad.mit.edu	37	17	7225205	7225205	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr17:7225205C>T	ENST00000399464.2	-	17	2865	c.2850G>A	c.(2848-2850)ctG>ctA	p.L950L	NEURL4_ENST00000570460.1_Silent_p.L926L|NEURL4_ENST00000315614.7_Silent_p.L948L	NM_032442.2	NP_115818.2			neuralized E3 ubiquitin protein ligase 4											central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CCTCAGCCCTCAGCTCCTTGG	0.567000													11	16					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88966053	88966053	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr7:88966053C>G	ENST00000333190.4	+	4	4366	c.3757C>G	c.(3757-3759)Cca>Gca	p.P1253A		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1253						intracellular	zinc ion binding	p.P1253A(1)		NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			GACTCTGACTCCAACCATTAT	0.468000										HNSCC(36;0.09)			58	54					0	0	1	0	0
HIST1H3H	8357	broad.mit.edu	37	6	27777959	27777959	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:27777959C>T	ENST00000369163.2	+	1	118	c.108C>T	c.(106-108)gtC>gtT	p.V36V		NM_003536.2	NP_003527.1	P68431	H31_HUMAN	histone cluster 1, H3h	36					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|lung(4)|ovary(2)|upper_aerodigestive_tract(3)	10						CCGGCGGTGTCAAGAAGCCCC	0.642000													33	48					0	0	1	0	0
COPB1	1315	broad.mit.edu	37	11	14515869	14515869	+	Nonsense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr11:14515869G>A	ENST00000249923.3	-	3	508	c.208C>T	c.(208-210)Cag>Tag	p.Q70*	PSMA1_ENST00000555531.1_3'UTR|PSMA1_ENST00000419365.2_3'UTR|COPB1_ENST00000439561.2_Nonsense_Mutation_p.Q70*	NM_016451.4	NP_057535.1	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	70					COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	36						GTGTGATCCTGAAGAGGTAGC	0.368000													14	48					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157490994	157490994	+	Silent	SNP	C	C	T			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr1:157490994C>T	ENST00000361835.3	-	11	2485	c.2328G>A	c.(2326-2328)ctG>ctA	p.L776L	FCRL5_ENST00000461387.1_5'UTR|FCRL5_ENST00000356953.4_Silent_p.L776L	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	776	Ig-like C2-type 8.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				GAGAGCCTCTCAGGGCCTCAC	0.597000													43	58					0	0	1	0	0
TRIO	7204	broad.mit.edu	37	5	14487590	14487590	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr5:14487590G>A	ENST00000344204.4	+	48	6877	c.6853G>A	c.(6853-6855)Gag>Aag	p.E2285K	TRIO_ENST00000537187.1_Missense_Mutation_p.E2285K	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	2285					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					ATCGCCAATCGAGTACCAGAG	0.746000													9	18					0	0	1	0	0
DCLK3	85443	broad.mit.edu	37	3	36779863	36779863	+	Frame_Shift_Del	DEL	C	C	-			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:36779863delC	ENST00000416516.2	-	2	778	c.288delG	c.(286-288)gggfs	p.G96fs		NM_033403.1	NP_208382.1	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	96						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	48						ATTTCCCCCTCCCCCACTTCT	0.597													65	121	---	---	---	---					
GAP43	2596	broad.mit.edu	37	3	115395388	115395388	+	Frame_Shift_Del	DEL	G	G	-			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:115395388delG	ENST00000393780.3	+	3	1135	c.667delG	c.(667-669)gctfs	p.A225fs	GAP43_ENST00000305124.6_Frame_Shift_Del_p.A189fs	NM_001130064.1	NP_001123536.1	P17677	NEUM_HUMAN	growth associated protein 43	189					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	32				GBM - Glioblastoma multiforme(114;0.164)		cgcagaggatgctgctgcCAA	0.612													8	13	---	---	---	---					
MSL2	55167	broad.mit.edu	37	3	135871483	135871483	+	Frame_Shift_Del	DEL	G	G	-			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr3:135871483delG	ENST00000309993.2	-	2	972	c.240delC	c.(238-240)tccfs	p.S80fs	MSL2_ENST00000434835.2_Frame_Shift_Del_p.S6fs	NM_018133.3	NP_060603.2	Q9HCI7	MSL2_HUMAN	male-specific lethal 2 homolog (Drosophila)	80					histone H4-K16 acetylation	MSL complex	zinc ion binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	18						ACCAGCTACAGGAAGGTTTCA	0.403													7	229	---	---	---	---					
TCP10L2	401285	broad.mit.edu	37	6	167587243	167587244	+	Frame_Shift_Del	DEL	AT	AT	-			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr6:167587243_167587244delAT	ENST00000366832.2	+	3	278_279	c.147_148delAT	c.(145-150)tcattafs	p.L50fs		NM_001145121.1	NP_001138593.1	B9ZVM9	B9ZVM9_HUMAN	t-complex 10-like 2	50										endometrium(1)|kidney(2)|lung(3)	6						AATGACAGTCATTACAGCAGCA	0.515													3	5	---	---	---	---					
KMT2D	8085	broad.mit.edu	37	12	49415927	49415928	+	Frame_Shift_Ins	INS	-	-	A			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:49415927_49415928insA	ENST00000301067.7	-	53	16418_16419	c.16419_16420insT	c.(16417-16422)attaacfs	p.N5474fs		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		CAGGAATGGTTAATGTACCTGG	0.510													43	80	---	---	---	---					
MAP3K12	7786	broad.mit.edu	37	12	53876883	53876883	+	Frame_Shift_Del	DEL	G	G	-			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr12:53876883delG	ENST00000267079.2	-	12	1830	c.1605delC	c.(1603-1605)cccfs	p.P535fs	MAP3K12_ENST00000547488.1_Frame_Shift_Del_p.P568fs|MAP3K12_ENST00000547035.1_Frame_Shift_Del_p.P568fs	NM_001193511.1|NM_006301.3	NP_001180440.1|NP_006292.3	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase 12	535					histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(2)|breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	37						GTCCTGGTGAGGGGGGGCCCT	0.642													9	28	---	---	---	---					
LILRB3	11025	broad.mit.edu	37	19	54726271	54726271	+	Frame_Shift_Del	DEL	C	C	-			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:54726271delC	ENST00000391750.1	-	4	370	c.234delG	c.(232-234)aagfs	p.K78fs	LILRB3_ENST00000424807.1_Frame_Shift_Del_p.K78fs|LILRA6_ENST00000419410.2_Intron|LILRA6_ENST00000440558.2_Intron|LILRA6_ENST00000270464.5_Intron|LILRB3_ENST00000346401.6_Frame_Shift_Del_p.K78fs|LILRA6_ENST00000391735.3_Intron|LILRB3_ENST00000407860.2_Intron|LILRB3_ENST00000245620.9_Frame_Shift_Del_p.K78fs			O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	78	Ig-like C2-type 1.				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity			endometrium(3)|kidney(13)|large_intestine(1)|lung(6)|ovary(2)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	34	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGGCCTTGTTCTTGGGTTCCA	0.572													28	200	---	---	---	---					
LILRA6	79168	broad.mit.edu	37	19	54746023	54746023	+	Frame_Shift_Del	DEL	C	C	-			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chr19:54746023delC	ENST00000440558.2	-	3	282	c.234delG	c.(232-234)aagfs	p.K78fs	LILRA6_ENST00000419410.2_Frame_Shift_Del_p.K78fs|LILRA6_ENST00000270464.5_Frame_Shift_Del_p.K78fs|LILRA6_ENST00000391735.3_Frame_Shift_Del_p.K78fs|LILRA6_ENST00000396365.2_Frame_Shift_Del_p.K78fs|LILRA6_ENST00000245621.5_Frame_Shift_Del_p.K78fs|LILRB3_ENST00000407860.2_Frame_Shift_Del_p.K78fs					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6											central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(20)|ovary(3)|skin(2)|urinary_tract(2)	38	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGGCCTTGTTCTTGGGTTCCA	0.567													7	314	---	---	---	---					
MAGEC1	9947	broad.mit.edu	37	X	140994260	140994260	+	Frame_Shift_Del	DEL	C	C	-			TCGA-4Z-AA7M-01A-11D-A391-08	TCGA-4Z-AA7M-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	17d7bb1b-b610-4c13-a8e6-116a705e935d	1979e3da-b70d-4777-b24d-956d1528486b	g.chrX:140994260delC	ENST00000285879.4	+	4	1356	c.1070delC	c.(1069-1071)tctfs	p.S357fs	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	357							protein binding	p.S357Y(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TTCCAGAGTTCTCCTGAGAGT	0.473										HNSCC(15;0.026)			33	81	---	---	---	---					
