Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MOAP1	64112	broad.mit.edu	37	14	93650050	93650050	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr14:93650050C>T	ENST00000556883.1	-	2	1022	c.538G>A	c.(538-540)Gaa>Aaa	p.E180K	MOAP1_ENST00000298894.4_Missense_Mutation_p.E180K			Q96BY2	MOAP1_HUMAN	modulator of apoptosis 1	180					activation of caspase activity|apoptotic nuclear change	cytoplasm	protein homodimerization activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)	13		all_cancers(154;0.00528)|Acute lymphoblastic leukemia(33;0.0497)|all_epithelial(191;0.125)|all_neural(303;0.13)		Epithelial(152;0.178)|all cancers(159;0.2)|COAD - Colon adenocarcinoma(157;0.204)		cgtccaaattcttcttctcct	0.512000													49	47					0	0	0.003610	0	0
TENM2	57451	broad.mit.edu	37	5	167553852	167553852	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr5:167553852G>A	ENST00000519204.1	+	11	2058	c.1940G>A	c.(1939-1941)cGc>cAc	p.R647H	TENM2_ENST00000545108.1_Missense_Mutation_p.R768H|TENM2_ENST00000520394.1_Missense_Mutation_p.R536H|TENM2_ENST00000518659.1_Missense_Mutation_p.R768H|TENM2_ENST00000403607.2_Missense_Mutation_p.R601H|CTB-178M22.1_ENST00000517408.1_RNA					teneurin transmembrane protein 2																		TGTGACCAGCGCGTGTGCCAC	0.602000													14	7					0	0	0.003163	0	0
SPC24	147841	broad.mit.edu	37	19	11258787	11258787	+	Silent	SNP	G	G	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:11258787G>T	ENST00000592540.1	-	3	343	c.312C>A	c.(310-312)ctC>ctA	p.L104L		NM_182513.2	NP_872319.1	Q8NBT2	SPC24_HUMAN	SPC24, NDC80 kinetochore complex component	104	Interaction with the N-terminus of SPBC25.				cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|prostate(1)	5						GCTCTCTGGTGAGCTGAGTAG	0.607000													7	18					2.0095e-06	2.32679e-06	0.001984	1	0
KRI1	65095	broad.mit.edu	37	19	10668297	10668297	+	Silent	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:10668297G>A	ENST00000312962.6	-	16	1585	c.1566C>T	c.(1564-1566)atC>atT	p.I522I	KRI1_ENST00000361821.5_Silent_p.I518I	NM_023008.3	NP_075384.3	Q8N9T8	KRI1_HUMAN	KRI1 homolog (S. cerevisiae)	522										NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	26			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			GCAGGTCGTCGATGATGTCCT	0.617000													27	46					0	0	0.001786	0	0
CENPF	1063	broad.mit.edu	37	1	214826232	214826232	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:214826232C>T	ENST00000366955.3	+	16	8390	c.8222C>T	c.(8221-8223)tCa>tTa	p.S2741L	CENPF_ENST00000467765.1_3'UTR	NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	2837	Sufficient for centromere localization.|Sufficient for self-association.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		TGTCTCAGTTCACAGAAGCTG	0.328000													40	39					0	0	0.006230	0	0
ZFHX3	463	broad.mit.edu	37	16	72821414	72821414	+	Silent	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:72821414C>T	ENST00000268489.5	-	10	11433	c.10761G>A	c.(10759-10761)tcG>tcA	p.S3587S	ZFHX3_ENST00000397992.5_Silent_p.S2673S	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	3587					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				CGGCAGACTGCGAGGTAGATG	0.617000													64	85					0	0	0.003610	0	0
TTN	7273	broad.mit.edu	37	2	179612753	179612753	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr2:179612753C>A	ENST00000360870.5	-	46	14596	c.14374G>T	c.(14374-14376)Gca>Tca	p.A4792S	TTN_ENST00000589042.1_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342992.6_Intron|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000590773.1_RNA	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	901	Ig-like 28.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGAAATGCTGCCAACTCTGGT	0.458000													30	29					3.73988e-18	4.42748e-18	0.006320	1	0
STYK1	55359	broad.mit.edu	37	12	10772796	10772796	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr12:10772796C>T	ENST00000075503.3	-	11	1736	c.1216G>A	c.(1216-1218)Gct>Act	p.A406T		NM_018423.2	NP_060893.2	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	406						integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	26						CCGGCCACAGCTGCATACAGT	0.483000										HNSCC(73;0.22)			123	130					0	0	0.003610	0	0
TIGD2	166815	broad.mit.edu	37	4	90034853	90034853	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:90034853C>G	ENST00000317005.2	+	1	886	c.728C>G	c.(727-729)tCa>tGa	p.S243*		NM_145715.2	NP_663761.1	Q4W5G0	TIGD2_HUMAN	tigger transposable element derived 2	243	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	14		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.86e-05)		ACTGACCTTTCAAACCTTCCT	0.423000													30	32					0	0	0.008361	0	0
OR8J3	81168	broad.mit.edu	37	11	55905037	55905037	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr11:55905037G>C	ENST00000301529.1	-	1	157	c.158C>G	c.(157-159)tCt>tGt	p.S53C		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	53					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					TTGAAGTCGAGAGTCAACACT	0.473000													94	96					0	0	0.003610	0	0
CATSPER2	117155	broad.mit.edu	37	15	43939559	43939559	+	Silent	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr15:43939559C>T	ENST00000396879.1	-	4	364	c.252G>A	c.(250-252)ttG>ttA	p.L84L	CATSPER2_ENST00000321596.5_Silent_p.L84L|CATSPER2_ENST00000354127.4_Silent_p.L84L|CATSPER2_ENST00000355438.2_Silent_p.L84L|CATSPER2_ENST00000464721.1_5'UTR|CATSPER2_ENST00000381761.1_Silent_p.L90L|STRC_ENST00000541030.1_Intron	NM_001282309.1	NP_001269238.1	Q96P56	CTSR2_HUMAN	cation channel, sperm associated 2	84					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|protein binding|voltage-gated ion channel activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	22		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		GAAGCCTGCTCAACAGCCTCT	0.498000													38	151					0	0	0.006230	0	0
TMEM132D	121256	broad.mit.edu	37	12	130185145	130185145	+	Missense_Mutation	SNP	A	A	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr12:130185145A>T	ENST00000422113.2	-	2	504	c.178T>A	c.(178-180)Ttc>Atc	p.F60I		NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	60						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TTCAGGAAGAAGGAGACGTCC	0.552000													41	40					0	0	0.006999	0	0
ZNF93	81931	broad.mit.edu	37	19	20044762	20044762	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:20044762G>C	ENST00000343769.5	+	4	1026	c.998G>C	c.(997-999)aGa>aCa	p.R333T	AC007204.2_ENST00000592245.1_lincRNA	NM_031218.3	NP_112495.2	P35789	ZNF93_HUMAN	zinc finger protein 93	333						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R333I(1)		endometrium(6)|kidney(2)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	24						ACACATAAGAGAATTCATACT	0.378000													31	10					0	0	0.001786	0	0
HMCN1	83872	broad.mit.edu	37	1	186034488	186034488	+	Silent	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:186034488C>T	ENST00000271588.4	+	49	7861	c.7632C>T	c.(7630-7632)caC>caT	p.H2544H	HMCN1_ENST00000367492.2_Silent_p.H2544H	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	2544	Ig-like C2-type 23.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						AGGTGCCACACACTGGAAGAT	0.458000													4	34					0	0	0.000248	0	0
PKMYT1	9088	broad.mit.edu	37	16	3025757	3025757	+	Silent	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:3025757G>A	ENST00000431515.2	-	4	820	c.435C>T	c.(433-435)ttC>ttT	p.F145F	PKMYT1_ENST00000574385.1_Silent_p.F136F|PKMYT1_ENST00000573944.1_Silent_p.F136F|PKMYT1_ENST00000440027.2_Silent_p.F145F|PKMYT1_ENST00000574730.1_Silent_p.F76F|PKMYT1_ENST00000262300.8_Silent_p.F145F			Q99640	PMYT1_HUMAN	protein kinase, membrane associated tyrosine/threonine 1	145	Protein kinase.				G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis	endoplasmic reticulum membrane|Golgi membrane|membrane fraction|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	10						TGGGGCCCCGGAATGGTGACA	0.677000													33	24					0	0	0.002445	0	0
TLK2	11011	broad.mit.edu	37	17	60598163	60598163	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:60598163G>C	ENST00000326270.9	+	3	379	c.111G>C	c.(109-111)caG>caC	p.Q37H	TLK2_ENST00000346027.5_Missense_Mutation_p.Q37H|TLK2_ENST00000343388.7_Missense_Mutation_p.Q37H|TLK2_ENST00000542523.1_Missense_Mutation_p.Q37H|TLK2_ENST00000582809.1_5'UTR	NM_001284333.1	NP_001271262.1	Q86UE8	TLK2_HUMAN	tousled-like kinase 2	37					cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(4)|large_intestine(6)|liver(2)|lung(10)|prostate(1)|stomach(1)|urinary_tract(1)	39						CTTCCAACCAGAGCTTGTGCA	0.388000													47	110					0	0	0.003610	0	0
PXDNL	137902	broad.mit.edu	37	8	52321351	52321351	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr8:52321351C>T	ENST00000356297.4	-	17	2933	c.2833G>A	c.(2833-2835)Gcg>Acg	p.A945T	PXDNL_ENST00000543296.1_Missense_Mutation_p.A945T	NM_144651.4	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	945					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity	p.A945T(1)|p.A144T(1)		NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TCCTGTCGCGCGCACTCGGTG	0.647000													12	19					0	0	0.000978	0	0
CSE1L	1434	broad.mit.edu	37	20	47707561	47707561	+	Splice_Site	SNP	T	T	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr20:47707561T>G	ENST00000262982.2	+	21	2488		c.e21+2		CSE1L_ENST00000469700.1_Splice_Site|CSE1L_ENST00000542325.1_Splice_Site|CSE1L_ENST00000396192.3_Splice_Site	NM_001256135.1|NM_001316.3	NP_001243064.1|NP_001307.2	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like (yeast)						apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(11)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	35			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			TTATCAAGAGTAAGTAAAATC	0.313000													12	45					0	0	0.003330	0	0
TDP1	55775	broad.mit.edu	37	14	90455360	90455360	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr14:90455360G>C	ENST00000335725.4	+	11	1493	c.1243G>C	c.(1243-1245)Gag>Cag	p.E415Q	TDP1_ENST00000393454.2_Missense_Mutation_p.E415Q|TDP1_ENST00000393452.3_Missense_Mutation_p.E415Q|TDP1_ENST00000357382.3_Missense_Mutation_p.E176Q|TDP1_ENST00000555880.1_Missense_Mutation_p.E415Q	NM_018319.3	NP_060789.2	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	415					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|prostate(1)|urinary_tract(1)	25		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		GTTATGTTCTGAGTTTAAAGA	0.493000								Repair of DNA-protein crosslinks					32	39					0	0	0.002445	0	0
MSRB2	22921	broad.mit.edu	37	10	23399191	23399191	+	Silent	SNP	G	G	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr10:23399191G>T	ENST00000376510.3	+	3	343	c.240G>T	c.(238-240)ctG>ctT	p.L80L		NM_012228.3	NP_036360.3	Q9Y3D2	MSRB2_HUMAN	methionine sulfoxide reductase B2	80					protein repair	mitochondrion	peptide-methionine-(S)-S-oxide reductase activity|protein-methionine-R-oxide reductase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|large_intestine(2)|lung(4)|skin(1)|urinary_tract(1)	9					L-Methionine(DB00134)	GGATCTACCTGAATAACAAGG	0.428000													20	22					2.4624e-09	2.87643e-09	0.008871	1	0
TNFAIP8L3	388121	broad.mit.edu	37	15	51397240	51397240	+	Missense_Mutation	SNP	A	A	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr15:51397240A>T	ENST00000327536.5	-	1	233	c.134T>A	c.(133-135)aTc>aAc	p.I45N	RP11-108K3.1_ENST00000559909.1_lincRNA	NM_207381.2	NP_997264.2	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein 8-like 3	45										endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	11				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)		AGATAAGGGGATGAGTCTTGT	0.532000													12	102					0	0	0.001882	0	0
GAD2	2572	broad.mit.edu	37	10	26559631	26559631	+	Silent	SNP	C	C	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr10:26559631C>A	ENST00000376261.3	+	10	1541	c.1038C>A	c.(1036-1038)ccC>ccA	p.P346P	GAD2_ENST00000259271.3_Silent_p.P346P	NM_001134366.1	NP_001127838.1	Q05329	DCE2_HUMAN	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	346					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(26)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	48					L-Glutamic Acid(DB00142)	CATTTGACCCCCTCTTAGCTG	0.488000													80	69					2.65773e-34	3.20384e-34	0.003610	1	0
RGS12	6002	broad.mit.edu	37	4	3416499	3416499	+	Silent	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:3416499C>T	ENST00000336727.3	+	6	3115	c.2211C>T	c.(2209-2211)ttC>ttT	p.F737F	RGS12_ENST00000344733.5_Silent_p.F737F|RGS12_ENST00000543385.1_3'UTR|RGS12_ENST00000382788.3_Silent_p.F737F|RGS12_ENST00000338806.4_Silent_p.F89F|RGS12_ENST00000538395.1_Silent_p.F79F|RGS12_ENST00000508158.1_3'UTR|RGS12_ENST00000306648.7_Silent_p.F135F	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	737	RGS.					condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GGAAAGAATTCAGTGAAGAAA	0.413000													48	169					0	0	0.003610	0	0
KIF13A	63971	broad.mit.edu	37	6	17777582	17777582	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr6:17777582C>T	ENST00000378814.5	-	33	4056	c.4057G>A	c.(4057-4059)Gtc>Atc	p.V1353I	KIF13A_ENST00000378843.2_Missense_Mutation_p.V1353I|KIF13A_ENST00000378816.5_Missense_Mutation_p.V1366I|KIF13A_ENST00000259711.6_Missense_Mutation_p.V1366I|KIF13A_ENST00000378826.2_Missense_Mutation_p.V1366I	NM_001105568.2	NP_001099038.1	Q9H1H9	KI13A_HUMAN	kinesin family member 13A	1366					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TTGACTGTGACGGCCTGTAAA	0.448000													4	28					0	0	0.000248	0	0
PCDHGB7	56099	broad.mit.edu	37	5	140798486	140798486	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr5:140798486G>C	ENST00000398594.2	+	1	1060	c.1060G>C	c.(1060-1062)Gat>Cat	p.D354H	PCDHGA3_ENST00000253812.6_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA9_ENST00000573521.1_Intron	NM_018927.3	NP_061750.1														central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(13)|lung(15)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(3)	56			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCACTCTCTGATCAGATTAT	0.463000													26	26					0	0	0.008361	0	0
TNFAIP8L3	388121	broad.mit.edu	37	15	51397222	51397222	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr15:51397222A>G	ENST00000327536.5	-	1	251	c.152T>C	c.(151-153)cTt>cCt	p.L51P	RP11-108K3.1_ENST00000559909.1_lincRNA	NM_207381.2	NP_997264.2	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein 8-like 3	51										endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	11				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)		TCCCCTCTGAAGATGAAAAGA	0.542000													14	110					0	0	0.003954	0	0
CD34	947	broad.mit.edu	37	1	208061201	208061201	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:208061201G>A	ENST00000310833.7	-	8	1361	c.1040C>T	c.(1039-1041)cCt>cTt	p.P347L	CD34_ENST00000367036.3_Missense_Mutation_p.P189L|CD34_ENST00000537704.1_Missense_Mutation_p.P212L|CD34_ENST00000485761.1_Intron|CD34_ENST00000356522.4_3'UTR	NM_001025109.1	NP_001020280.1	P28906	CD34_HUMAN	CD34 molecule	347					cell-cell adhesion|leukocyte migration|regulation of immune response	integral to membrane	carbohydrate binding			kidney(2)|large_intestine(2)|lung(8)|ovary(1)	13						CTGAGCCTCAGGGGAGGTCCC	0.557000													32	26					0	0	0.001786	0	0
SIGIRR	59307	broad.mit.edu	37	11	407866	407866	+	Silent	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr11:407866G>C	ENST00000431843.2	-	5	738	c.432C>G	c.(430-432)ctC>ctG	p.L144L	SIGIRR_ENST00000531205.1_Silent_p.L144L|SIGIRR_ENST00000397632.3_Silent_p.L144L|SIGIRR_ENST00000332725.3_Silent_p.L144L|SIGIRR_ENST00000529486.1_5'UTR|SIGIRR_ENST00000382520.2_Silent_p.L144L	NM_001135054.1	NP_001128526.1	Q6IA17	SIGIR_HUMAN	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain	144					acute-phase response|innate immune response|negative regulation of chemokine biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity	integral to membrane	protein binding|transmembrane receptor activity			cervix(2)|endometrium(1)|liver(1)|lung(5)|prostate(2)|skin(1)|urinary_tract(1)	13		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCAGCACGTTGAGACGGCACT	0.687000													55	3					0	0	0.003610	0	0
PDE3A	5139	broad.mit.edu	37	12	20774241	20774241	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr12:20774241G>A	ENST00000359062.3	+	5	1476	c.1436G>A	c.(1435-1437)tGg>tAg	p.W479*	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	479					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CCTGATTCTTGGAATAATCCA	0.378000													13	19					0	0	0.001368	0	0
HCFC2	29915	broad.mit.edu	37	12	104476336	104476336	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr12:104476336C>T	ENST00000229330.4	+	6	930	c.826C>T	c.(826-828)Cat>Tat	p.H276Y		NM_013320.2	NP_037452.1	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2	276					regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|lung(14)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	35						GACTTCACCTCATGATTGTGA	0.333000													21	38					0	0	0.002299	0	0
PCLO	27445	broad.mit.edu	37	7	82785410	82785410	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr7:82785410C>T	ENST00000333891.9	-	2	884	c.547G>A	c.(547-549)Gag>Aag	p.E183K	PCLO_ENST00000423517.2_Missense_Mutation_p.E183K	NM_033026.5	NP_149015.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein						cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TGGGATGCCTCAGAGTCTGAT	0.418000													29	30					0	0	0.002096	0	0
RENBP	5973	broad.mit.edu	37	X	153205630	153205630	+	Silent	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chrX:153205630G>A	ENST00000393700.3	-	9	1082	c.1002C>T	c.(1000-1002)ctC>ctT	p.L334L	RENBP_ENST00000412763.1_3'UTR|RENBP_ENST00000369997.3_Silent_p.L320L	NM_002910.5	NP_002901.2	P51606	RENBP_HUMAN	renin binding protein	334					mannose metabolic process|regulation of blood pressure		endopeptidase inhibitor activity|mannose-6-phosphate isomerase activity|N-acylglucosamine 2-epimerase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	20	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				N-Acetyl-D-glucosamine(DB00141)	TGTAACCCATGAGGAAGGCAA	0.602000													46	1					0	0	0.003610	0	0
CETP	1071	broad.mit.edu	37	16	57005235	57005235	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:57005235C>G	ENST00000200676.3	+	7	730	c.600C>G	c.(598-600)atC>atG	p.I200M	CETP_ENST00000379780.2_Missense_Mutation_p.I200M|CETP_ENST00000566128.1_Missense_Mutation_p.I135M|CETP_ENST00000569082.1_3'UTR	NM_000078.2	NP_000069.2	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma	200					cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(4)|skin(3)	23						TGCCCCAGATCTGCAAAGAGA	0.577000													116	137					0	0	0.003610	0	0
QPRT	23475	broad.mit.edu	37	16	29706228	29706228	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:29706228G>A	ENST00000395384.4	+	2	418	c.257G>A	c.(256-258)aGa>aAa	p.R86K	QPRT_ENST00000562473.1_Intron|QPRT_ENST00000219771.7_Intron	NM_014298.3	NP_055113.2	Q15274	NADC_HUMAN	quinolinate phosphoribosyltransferase	86					protein oligomerization|quinolinate catabolic process|water-soluble vitamin metabolic process	cytosol	nicotinate-nucleotide diphosphorylase (carboxylating) activity|protein homodimerization activity	p.R86K(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)	9					Niacin(DB00627)	CCGGTGGCCAGAGTGGCCGAG	0.657000													40	37					0	0	0.002222	0	0
DDX60	55601	broad.mit.edu	37	4	169196559	169196559	+	Silent	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:169196559C>T	ENST00000393743.3	-	16	2532	c.2241G>A	c.(2239-2241)ttG>ttA	p.L747L		NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	747							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		CATCTCGTATCAAATAATGGC	0.403000													30	26					0	0	0.002096	0	0
SPG11	80208	broad.mit.edu	37	15	44876629	44876629	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr15:44876629G>C	ENST00000261866.7	-	30	5265	c.5249C>G	c.(5248-5250)tCc>tGc	p.S1750C	SPG11_ENST00000427534.2_Missense_Mutation_p.S1750C|SPG11_ENST00000558319.1_Missense_Mutation_p.S1750C|SPG11_ENST00000535302.2_Missense_Mutation_p.S1750C	NM_025137.3	NP_079413.3	Q96JI7	SPTCS_HUMAN	spastic paraplegia 11 (autosomal recessive)	1750					cell death	cytosol|integral to membrane|nucleus	protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	72		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		TGAGAAAAAGGAAGAAGCTGC	0.463000													34	38					0	0	0.002445	0	0
FAT1	2195	broad.mit.edu	37	4	187518864	187518864	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:187518864G>A	ENST00000441802.2	-	24	12549	c.12340C>T	c.(12340-12342)Cag>Tag	p.Q4114*		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	4114	EGF-like 4.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						GAATCACACTGACAAACGGCG	0.428000										HNSCC(5;0.00058)			23	29					0	0	0.003954	0	0
PKMYT1	9088	broad.mit.edu	37	16	3026845	3026845	+	Silent	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:3026845G>A	ENST00000431515.2	-	3	583	c.198C>T	c.(196-198)ctC>ctT	p.L66L	PKMYT1_ENST00000574385.1_Silent_p.L57L|PKMYT1_ENST00000573944.1_Silent_p.L57L|PKMYT1_ENST00000440027.2_Silent_p.L66L|PKMYT1_ENST00000574730.1_Intron|PKMYT1_ENST00000262300.8_Silent_p.L66L			Q99640	PMYT1_HUMAN	protein kinase, membrane associated tyrosine/threonine 1	66	Pro-rich.				G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis	endoplasmic reticulum membrane|Golgi membrane|membrane fraction|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	10						GAGGAGGGAAGAGGCGGCTGA	0.687000													4	4					0	0	0.000248	0	0
CECR2	27443	broad.mit.edu	37	22	18031822	18031822	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr22:18031822G>C	ENST00000400573.5	+	18	4325	c.4318G>C	c.(4318-4320)Gat>Cat	p.D1440H	CECR2_ENST00000400585.2_Missense_Mutation_p.D1298H|CECR2_ENST00000262608.8_Missense_Mutation_p.D1441H			Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2						chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		ACTTCCCCTGGATCAGGTAAG	0.498000													24	29					0	0	0.003954	0	0
RBPJL	11317	broad.mit.edu	37	20	43940948	43940948	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr20:43940948G>A	ENST00000343694.3	+	6	604	c.532G>A	c.(532-534)Ggc>Agc	p.G178S	RBPJL_ENST00000372743.1_Missense_Mutation_p.G178S|RBPJL_ENST00000372741.3_Missense_Mutation_p.G178S	NM_001281448.1|NM_001281449.1|NM_014276.2	NP_001268377.1|NP_001268378.1|NP_055091.2	Q9UBG7	RBPJL_HUMAN	recombination signal binding protein for immunoglobulin kappa J region-like	178					signal transduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|kidney(1)|large_intestine(5)|lung(3)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Myeloproliferative disorder(115;0.0122)				gctgcgCGGGGGCCGGGAGCT	0.612000													16	24					0	0	0.004007	0	0
HNRNPU	3192	broad.mit.edu	37	1	245018742	245018742	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:245018742C>G	ENST00000444376.2	-	12	2513	c.2279G>C	c.(2278-2280)aGa>aCa	p.R760T	HNRNPU-AS1_ENST00000475997.1_RNA|HNRNPU_ENST00000283179.9_Missense_Mutation_p.R779T	NM_004501.3|NM_031844.2	NP_004492.2|NP_114032.2	Q00839	HNRPU_HUMAN	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	779	Gly-rich.				CRD-mediated mRNA stabilization	catalytic step 2 spliceosome|cell surface|CRD-mediated mRNA stability complex|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	ATP binding|DNA binding|protein binding|RNA binding			NS(1)|endometrium(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			GTAGTTCCCTCTGTTGGGCAT	0.478000													99	163					0	0	0.003610	0	0
STK10	6793	broad.mit.edu	37	5	171471888	171471888	+	Nonstop_Mutation	SNP	A	A	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr5:171471888A>C	ENST00000176763.5	-	19	3248	c.2905T>G	c.(2905-2907)Taa>Gaa	p.*969E		NM_005990.3	NP_005981.3	O94804	STK10_HUMAN	serine/threonine kinase 10	0							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(6)|pancreas(1)|prostate(1)|testis(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GGCGGTTGTTAAGAAGCATCC	0.592000													47	52					0	0	0.003610	0	0
CR2	1380	broad.mit.edu	37	1	207647168	207647168	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:207647168G>C	ENST00000367057.3	+	12	2367	c.2178G>C	c.(2176-2178)caG>caC	p.Q726H	CR2_ENST00000367059.3_Missense_Mutation_p.Q667H|CR2_ENST00000367058.3_Missense_Mutation_p.Q667H|CR2_ENST00000458541.2_Missense_Mutation_p.Q640H	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	788	Sushi 12.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						ATGTGAGACAGAGTCTTCAAG	0.418000													66	71					0	0	0.003610	0	0
MIB1	57534	broad.mit.edu	37	18	19345741	19345741	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr18:19345741C>G	ENST00000261537.6	+	2	502	c.238C>G	c.(238-240)Cat>Gat	p.H80D	MIB1_ENST00000578646.1_3'UTR	NM_020774.2	NP_065825.1	Q86YT6	MIB1_HUMAN	mindbomb E3 ubiquitin protein ligase 1	80					Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|ovary(5)	27			STAD - Stomach adenocarcinoma(5;0.212)			AGGCATCAAGCATGATGGAAC	0.363000													32	39					0	0	0.003271	0	0
PTP4A2	8073	broad.mit.edu	37	1	32384631	32384631	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:32384631C>G	ENST00000344035.6	-	2	1029	c.36G>C	c.(34-36)gaG>gaC	p.E12D	PTP4A2_ENST00000356536.3_Missense_Mutation_p.E12D|PTP4A2_ENST00000470404.1_Missense_Mutation_p.E12D|PTP4A2_ENST00000602725.1_Missense_Mutation_p.E12D|PTP4A2_ENST00000457805.2_Missense_Mutation_p.E12D|RP11-84A19.4_ENST00000602889.1_lincRNA	NM_080391.3	NP_536316.1	Q12974	TP4A2_HUMAN	protein tyrosine phosphatase type IVA, member 2	12						early endosome|plasma membrane	prenylated protein tyrosine phosphatase activity|protein binding|protein tyrosine/serine/threonine phosphatase activity			kidney(1)|large_intestine(1)|lung(1)|urinary_tract(1)	4		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)				AACGCATGTTCTCATAGGAGA	0.413000													34	42					0	0	0.003271	0	0
CSH1	1442	broad.mit.edu	37	17	61972839	61972839	+	Silent	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:61972839C>T	ENST00000329882.8	-	4	520	c.450G>A	c.(448-450)ctG>ctA	p.L150L	CSH1_ENST00000453363.3_Intron|CSH1_ENST00000316193.8_Silent_p.L150L			P01243	CSH_HUMAN	chorionic somatomammotropin hormone 1 (placental lactogen)	150					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding			central_nervous_system(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	8						TCACCCCCATCAGCGTTTGGA	0.562000									Russell-Silver syndrome				45	91					0	0	0.003610	0	0
SSBP3	23648	broad.mit.edu	37	1	54867580	54867580	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:54867580C>G	ENST00000371320.3	-	4	640	c.230G>C	c.(229-231)aGa>aCa	p.R77T	SSBP3_ENST00000371319.3_Missense_Mutation_p.R77T|SSBP3_ENST00000357475.4_Missense_Mutation_p.R77T|SSBP3_ENST00000417664.2_5'UTR	NM_145716.2	NP_663768.1	Q9BWW4	SSBP3_HUMAN	single stranded DNA binding protein 3	77					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	single-stranded DNA binding			central_nervous_system(2)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(1)	11						ACAAGTGTCTCTCCTTTCAGG	0.368000													42	57					0	0	0.003610	0	0
DGCR8	54487	broad.mit.edu	37	22	20073687	20073687	+	Silent	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr22:20073687C>T	ENST00000351989.3	+	2	630	c.201C>T	c.(199-201)ttC>ttT	p.F67F	DGCR8_ENST00000383024.2_Silent_p.F67F|DGCR8_ENST00000407755.1_Silent_p.F67F	NM_022720.6	NP_073557.3	Q8WYQ5	DGCR8_HUMAN	DGCR8 microprocessor complex subunit	67	Necessary for interaction with NCL.|Necessary for nuclear localization and retention.				primary miRNA processing	cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding			NS(2)|breast(1)|endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	Colorectal(54;0.0993)					AGGACCCCTTCAACTTCTACG	0.597000													50	56					0	0	0.003610	0	0
PSIP1	11168	broad.mit.edu	37	9	15468842	15468842	+	Splice_Site	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr9:15468842C>G	ENST00000380733.4	-	14	1550		c.e14-1		PSIP1_ENST00000380738.4_Splice_Site			O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1						initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(2)|endometrium(2)|kidney(1)|lung(3)|prostate(1)	9				GBM - Glioblastoma multiforme(50;2.38e-06)		ATCGCCGTATCTGAGAAAACA	0.299000													20	3					0	0	0.008871	0	0
TBC1D3P5	440419	broad.mit.edu	37	17	25749173	25749173	+	RNA	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:25749173G>C	ENST00000586223.1	+	0	1074					NR_033892.1																						ACAGCTAATTGATTGAGTGTA	0.502000													13	15					0	0	0.001855	0	0
EMC1	23065	broad.mit.edu	37	1	19549914	19549914	+	Silent	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:19549914G>A	ENST00000477853.1	-	19	2394	c.2352C>T	c.(2350-2352)atC>atT	p.I784I	EMC1_ENST00000375199.3_Silent_p.I783I|RP1-43E13.2_ENST00000437898.1_RNA|EMC1_ENST00000375208.3_Silent_p.I762I	NM_001271427.1|NM_001271428.1|NM_015047.2	NP_001258356.1|NP_001258357.1|NP_055862.1			ER membrane protein complex subunit 1									p.I784I(1)									CTGAATGCACGATATGGACAG	0.537000													86	163					0	0	0.003610	0	0
ANKFY1	51479	broad.mit.edu	37	17	4080443	4080443	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:4080443G>C	ENST00000341657.4	-	19	2788	c.2753C>G	c.(2752-2754)tCa>tGa	p.S918*	CYB5D2_ENST00000573984.1_Intron|ANKFY1_ENST00000570535.1_Nonsense_Mutation_p.S960*|ANKFY1_ENST00000574367.1_Nonsense_Mutation_p.S919*	NM_016376.3	NP_057460.3	Q9P2R3	ANFY1_HUMAN	ankyrin repeat and FYVE domain containing 1	918						endosome membrane	metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(11)|liver(1)|lung(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32						AATAATTTCTGAGCCTGCTTG	0.448000													45	1					0	0	0.003610	0	0
CRTC2	200186	broad.mit.edu	37	1	153921728	153921728	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:153921728G>C	ENST00000368633.1	-	12	1664	c.1537C>G	c.(1537-1539)Cag>Gag	p.Q513E	CRTC2_ENST00000368630.3_Missense_Mutation_p.Q193E	NM_181715.2	NP_859066.1	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	513					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			NS(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	27	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GAACAAGACTGAGAGGGCAGC	0.617000													45	45					0	0	0.002522	0	0
ZNF827	152485	broad.mit.edu	37	4	146686180	146686180	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:146686180C>G	ENST00000508784.1	-	13	3417	c.3190G>C	c.(3190-3192)Gag>Cag	p.E1064Q	ZNF827_ENST00000379448.4_Missense_Mutation_p.E1064Q|ZNF827_ENST00000513320.1_Missense_Mutation_p.E714Q			Q17R98	ZN827_HUMAN	zinc finger protein 827	1064					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	all_hematologic(180;0.151)					TTCTTATGCTCCAGCAGCTGT	0.483000													3	162					0	0	0.004672	0	0
AGL	178	broad.mit.edu	37	1	100366410	100366410	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:100366410G>A	ENST00000294724.4	+	26	4059	c.3581G>A	c.(3580-3582)gGc>gAc	p.G1194D	AGL_ENST00000361302.3_Missense_Mutation_p.G1178D|AGL_ENST00000370163.3_Missense_Mutation_p.G1194D|AGL_ENST00000370165.3_Missense_Mutation_p.G1194D|AGL_ENST00000370161.2_Missense_Mutation_p.G1178D|AGL_ENST00000361915.3_Missense_Mutation_p.G1194D|AGL_ENST00000361522.4_Missense_Mutation_p.G1177D	NM_000028.2	NP_000019.2	P35573	GDE_HUMAN	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	1194					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(9)|lung(35)|ovary(1)|prostate(4)|skin(3)|urinary_tract(1)	69		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		TTGCCTGCTGGCACACTGGTA	0.318000													4	144					0	0	0.000248	0	0
SCAPER	49855	broad.mit.edu	37	15	76763592	76763592	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr15:76763592C>G	ENST00000538941.2	-	25	3240	c.2301G>C	c.(2299-2301)aaG>aaC	p.K767N	SCAPER_ENST00000563290.1_Missense_Mutation_p.K1013N|SCAPER_ENST00000324767.7_Missense_Mutation_p.K1013N	NM_001145923.1	NP_001139395.1	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	1012	Glu-rich.					endoplasmic reticulum|nucleus	zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(16)|ovary(2)|prostate(2)|skin(1)|urinary_tract(2)	39						AGAAGGTAATCTTGTTACTAA	0.378000													27	40					0	0	0.007291	0	0
RTKN2	219790	broad.mit.edu	37	10	63978015	63978015	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr10:63978015C>G	ENST00000373789.3	-	8	923	c.827G>C	c.(826-828)cGa>cCa	p.R276P	RTKN2_ENST00000315289.2_Missense_Mutation_p.R57P|RTKN2_ENST00000395265.1_Missense_Mutation_p.R276P	NM_145307.2	NP_660350.2	Q8IZC4	RTKN2_HUMAN	rhotekin 2	276					signal transduction	intracellular				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Prostate(12;0.0297)|all_hematologic(501;0.215)					GGCAACTAGTCGGCAGCACAT	0.368000													41	50					0	0	0.002852	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90162513	90162513	+	RNA	SNP	T	T	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:90162513T>C	ENST00000567960.1	+	0	1249				TUBB8P7_ENST00000564451.1_RNA														p.N415N(2)									GCAACATGAATGACCTGGTGT	0.537000													4	161					0	0	0.000602	0	0
DNAJC11	55735	broad.mit.edu	37	1	6694739	6694739	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:6694739C>T	ENST00000349363.6	-	8	845	c.804G>A	c.(802-804)tgG>tgA	p.W268*	DNAJC11_ENST00000465508.1_5'UTR|DNAJC11_ENST00000377577.5_3'UTR|THAP3_ENST00000377627.3_3'UTR			Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	0					protein folding		heat shock protein binding|unfolded protein binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(11)|lung(8)|ovary(2)|skin(1)|urinary_tract(1)	32	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		ATTCTGCATCCCAAGTGGGCA	0.647000											OREG0013046	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	8					0	0	0.004990	0	0
HSD17B3	3293	broad.mit.edu	37	9	98997817	98997817	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr9:98997817G>C	ENST00000375263.3	-	11	905	c.858C>G	c.(856-858)ttC>ttG	p.F286L	HSD17B3_ENST00000375262.2_Missense_Mutation_p.F236L|HSD17B3_ENST00000464104.1_5'UTR	NM_000197.1	NP_000188.1	P37058	DHB3_HUMAN	hydroxysteroid (17-beta) dehydrogenase 3	286					androgen biosynthetic process|male genitalia development	endoplasmic reticulum membrane|microsome	binding|testosterone 17-beta-dehydrogenase (NAD+) activity|testosterone 17-beta-dehydrogenase (NADP+) activity	p.F286F(1)		breast(1)|endometrium(3)|large_intestine(2)|lung(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13		Acute lymphoblastic leukemia(62;0.0171)|all_hematologic(171;0.214)			NADH(DB00157)	CACCGCTGTAGAAGGCCCAGG	0.537000													18	0					0	0	0.001882	0	0
RPS18	6222	broad.mit.edu	37	6	33243640	33243640	+	Missense_Mutation	SNP	G	G	A	rs3208874		TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr6:33243640G>A	ENST00000439602.2	+	3	279	c.169G>A	c.(169-171)Gga>Aga	p.G57R	RPS18_ENST00000476222.1_3'UTR|RPS18_ENST00000474973.1_5'UTR			P62269	RS18_HUMAN	ribosomal protein S18	57					endocrine pancreas development|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	rRNA binding|structural constituent of ribosome			kidney(2)|large_intestine(2)|lung(2)|prostate(2)|urinary_tract(1)	9						CAAGAGGGCGGGAGAACTCAC	0.552000													4	152					0	0	0.000248	0	0
RASGRF2	5924	broad.mit.edu	37	5	80422929	80422929	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr5:80422929C>T	ENST00000265080.4	+	17	2700	c.2633C>T	c.(2632-2634)cCg>cTg	p.P878L		NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	878					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		TCTGTTTCACCGGCTTCTGCT	0.448000													25	41					0	0	0.003954	0	0
PSD	5662	broad.mit.edu	37	10	104173719	104173719	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr10:104173719C>T	ENST00000020673.5	-	5	1886	c.1360G>A	c.(1360-1362)Gac>Aac	p.D454N	PSD_ENST00000406432.1_Missense_Mutation_p.D454N	NM_001270966.1|NM_002779.4	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	454	Pro-rich.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|endometrium(2)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		GCTGGTGGGTCGGGCCGGGGT	0.662000													47	32					0	0	0.003610	0	0
TAB2	23118	broad.mit.edu	37	6	149700620	149700620	+	Silent	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr6:149700620G>C	ENST00000367456.1	+	4	2146	c.1569G>C	c.(1567-1569)ctG>ctC	p.L523L	TAB2_ENST00000286332.5_Silent_p.L523L|TAB2_ENST00000538427.1_Silent_p.L523L|TAB2_ENST00000536230.1_Silent_p.L491L|TAB2_ENST00000392282.1_Silent_p.L523L			Q9NYJ8	TAB2_HUMAN	TGF-beta activated kinase 1/MAP3K7 binding protein 2	523					activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	22						CACGGAAACTGAGTATGGGAT	0.413000													35	31					0	0	0.003271	0	0
TENC1	23371	broad.mit.edu	37	12	53454002	53454002	+	Silent	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr12:53454002G>A	ENST00000314250.6	+	18	2867	c.2577G>A	c.(2575-2577)ttG>ttA	p.L859L	TENC1_ENST00000314276.3_Silent_p.L869L|TENC1_ENST00000451358.1_Silent_p.L849L|TENC1_ENST00000379902.3_Silent_p.L735L|TENC1_ENST00000552570.1_Silent_p.L859L|TENC1_ENST00000549700.1_Silent_p.L794L|TENC1_ENST00000546602.1_Intron	NM_170754.2	NP_736610.2	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase (tensin 2)	859	Pro-rich.				intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(19)|ovary(1)|pancreas(1)|stomach(3)	34						GGTACCCATTGCCTGGGCACC	0.637000													7	7					0	0	0.004482	0	0
RNF103	7844	broad.mit.edu	37	2	86832395	86832395	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr2:86832395G>A	ENST00000237455.4	-	4	1597	c.629C>T	c.(628-630)gCa>gTa	p.A210V	RNF103-CHMP3_ENST00000604011.1_Intron|CHMP3_ENST00000439940.2_Intron|RNF103_ENST00000477307.1_5'UTR|AC015971.2_ENST00000597638.1_RNA|AC015971.2_ENST00000439077.1_RNA|AC015971.2_ENST00000426549.1_RNA|AC015971.2_ENST00000424788.1_RNA	NM_001198951.1|NM_005667.3	NP_001185880.1|NP_005658.1	O00237	RN103_HUMAN	ring finger protein 103	210					central nervous system development|ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(7)|skin(2)	25						CCGAGAAGCTGCATGAGCAGT	0.343000													82	75					0	0	0.003610	0	0
WASH2P	375260	broad.mit.edu	37	2	114355998	114355998	+	RNA	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr2:114355998C>G	ENST00000538033.2	+	0	2178																											CCAAGGTGGGCACTTGATGTC	0.612000													4	24					0	0	0.001168	0	0
ADAM10	102	broad.mit.edu	37	15	58932978	58932978	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr15:58932978G>A	ENST00000260408.3	-	8	1453	c.1010C>T	c.(1009-1011)tCa>tTa	p.S337L	ADAM10_ENST00000396140.2_Missense_Mutation_p.S36L|ADAM10_ENST00000402627.1_Missense_Mutation_p.S36L|ADAM10_ENST00000561288.1_Intron	NM_001110.2	NP_001101.1	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10	337	Peptidase M12B.				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			breast(1)|endometrium(1)|kidney(5)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)	27				GBM - Glioblastoma multiforme(80;0.202)		TAAACTACCTGAAGGTGCTCC	0.388000													12	16					0	0	0.001855	0	0
CSE1L	1434	broad.mit.edu	37	20	47707519	47707519	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr20:47707519C>A	ENST00000262982.2	+	21	2448	c.2325C>A	c.(2323-2325)ttC>ttA	p.F775L	CSE1L_ENST00000469700.1_3'UTR|CSE1L_ENST00000542325.1_Missense_Mutation_p.F558L|CSE1L_ENST00000396192.3_Missense_Mutation_p.F719L	NM_001256135.1|NM_001316.3	NP_001243064.1|NP_001307.2	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like (yeast)	775					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(11)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	35			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			TTCTGCTATTCCAGAGACTTC	0.308000													16	62					1.61788e-16	1.90679e-16	0.002445	1	0
HS3ST1	9957	broad.mit.edu	37	4	11401132	11401132	+	Silent	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:11401132C>T	ENST00000002596.5	-	2	1672	c.498G>A	c.(496-498)caG>caA	p.Q166Q		NM_005114.2	NP_005105.1	O14792	HS3S1_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	166						Golgi lumen|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(6)|skin(3)	15						GCTTGTGCTTCTGCATGTGGT	0.587000													43	53					0	0	0.003610	0	0
ALOX12B	242	broad.mit.edu	37	17	7976526	7976526	+	Silent	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:7976526C>T	ENST00000319144.4	-	14	2126	c.1866G>A	c.(1864-1866)gtG>gtA	p.V622V	ALOX12B_ENST00000577351.1_5'UTR	NM_001139.2	NP_001130.1	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	622	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	16						ACGTGGTCTTCACATCCGGCA	0.622000										Multiple Myeloma(8;0.094)			4	119					0	0	0.000248	0	0
MEP1A	4224	broad.mit.edu	37	6	46806751	46806751	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr6:46806751G>T	ENST00000230588.4	+	14	2128	c.2119G>T	c.(2119-2121)Gag>Tag	p.E707*		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	707	EGF-like.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			CTACACGGGGGAGCGCTGTCA	0.587000													82	87					2.61895e-37	3.17157e-37	0.003610	1	0
CERKL	375298	broad.mit.edu	37	2	182413568	182413568	+	Silent	SNP	G	G	A	rs139270710		TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr2:182413568G>A	ENST00000410087.3	-	7	1012	c.912C>T	c.(910-912)gtC>gtT	p.V304V	CERKL_ENST00000339098.5_Silent_p.V330V|CERKL_ENST00000374970.2_Silent_p.V235V|CERKL_ENST00000374969.2_Silent_p.V191V|CERKL_ENST00000479558.1_5'UTR|CERKL_ENST00000409440.3_Silent_p.V286V	NM_001030311.2|NM_201548.4	NP_001025482.1|NP_963842.1	Q49MI3	CERKL_HUMAN	ceramide kinase-like	330	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|Golgi apparatus|nucleolus	diacylglycerol kinase activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(13)|ovary(3)|skin(3)	32			OV - Ovarian serous cystadenocarcinoma(117;0.088)			TGCAGACGTCGACCAGCTGTA	0.428000													22	34					0	0	0.003954	0	0
FLVCR2	55640	broad.mit.edu	37	14	76045321	76045321	+	Silent	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr14:76045321G>A	ENST00000238667.4	+	1	362	c.6G>A	c.(4-6)gtG>gtA	p.V2V	AC007182.6_ENST00000455232.1_RNA	NM_017791.2	NP_060261.2	Q9UPI3	FLVC2_HUMAN	feline leukemia virus subgroup C cellular receptor family, member 2	2					transmembrane transport	integral to membrane|plasma membrane	heme binding|heme transporter activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	15				BRCA - Breast invasive adenocarcinoma(234;0.029)		TGGCGATGGTGAATGAAGGTC	0.597000											OREG0022816	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	43					0	0	0.001786	0	0
GALNT7	51809	broad.mit.edu	37	4	174169341	174169341	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:174169341C>G	ENST00000265000.4	+	2	420	c.337C>G	c.(337-339)Ctc>Gtc	p.L113V	GALNT7_ENST00000512285.1_Missense_Mutation_p.L113V	NM_017423.2	NP_059119.2	Q86SF2	GALT7_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)	113					protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|kidney(3)|large_intestine(5)|liver(1)|lung(9)	19		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;1.87e-18)|Epithelial(43;3.44e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-09)|STAD - Stomach adenocarcinoma(60;0.0019)|GBM - Glioblastoma multiforme(59;0.0119)|LUSC - Lung squamous cell carcinoma(193;0.0199)		GAGGCAGTATCTCACATTTAA	0.463000													32	40					0	0	0.001786	0	0
STOML3	161003	broad.mit.edu	37	13	39544479	39544479	+	Missense_Mutation	SNP	T	T	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr13:39544479T>A	ENST00000379631.4	-	5	703	c.359A>T	c.(358-360)tAt>tTt	p.Y120F	STOML3_ENST00000423210.1_Missense_Mutation_p.Y111F	NM_145286.2	NP_660329.1	Q8TAV4	STML3_HUMAN	stomatin (EPB72)-like 3	120						integral to membrane|plasma membrane				breast(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	11		Lung NSC(96;1.42e-05)|Prostate(109;0.00851)|Breast(139;0.0199)|Lung SC(185;0.0743)		all cancers(112;2.93e-08)|Epithelial(112;3.64e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00107)|BRCA - Breast invasive adenocarcinoma(63;0.00349)|GBM - Glioblastoma multiforme(144;0.0137)		GATTCTGTAATAGACAACTCC	0.433000													69	86					0	0	0.003610	0	0
ZCCHC14	23174	broad.mit.edu	37	16	87446453	87446453	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:87446453G>C	ENST00000268616.4	-	12	1680	c.1463C>G	c.(1462-1464)tCa>tGa	p.S488*		NM_015144.2	NP_055959.1	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	488					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	36				BRCA - Breast invasive adenocarcinoma(80;0.0285)		GTGGTGGCCTGATGGATTGGA	0.612000													33	40					0	0	0.001786	0	0
HELZ	9931	broad.mit.edu	37	17	65175038	65175038	+	Silent	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:65175038G>A	ENST00000358691.5	-	13	1333	c.1167C>T	c.(1165-1167)ctC>ctT	p.L389L	HELZ_ENST00000580168.1_Silent_p.L389L	NM_014877.3	NP_055692			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TCAGGTATTCGAGATCTAAAT	0.279000													37	62					0	0	0.004289	0	0
SULT2B1	6820	broad.mit.edu	37	19	49090664	49090664	+	Silent	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:49090664C>T	ENST00000323090.4	+	2	723	c.348C>T	c.(346-348)ttC>ttT	p.F116F	SULT2B1_ENST00000201586.2_Silent_p.F131F	NM_004605.2	NP_004596.2	O00204	ST2B1_HUMAN	sulfotransferase family, cytosolic, 2B, member 1	131					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	alcohol sulfotransferase activity|protein binding|steroid sulfotransferase activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(2)|skin(2)|urinary_tract(1)	11		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000115)|all cancers(93;0.000147)|GBM - Glioblastoma multiforme(486;0.00707)|Epithelial(262;0.0178)		TCCAGATCTTCACCAAGGCCT	0.622000													47	66					0	0	0.003610	0	0
CRTAC1	55118	broad.mit.edu	37	10	99664461	99664461	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr10:99664461G>C	ENST00000370597.3	-	7	1316	c.961C>G	c.(961-963)Ctg>Gtg	p.L321V	CRTAC1_ENST00000298819.4_Missense_Mutation_p.L321V|CRTAC1_ENST00000370591.2_Missense_Mutation_p.L321V	NM_018058.6	NP_060528.3	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1	321						proteinaceous extracellular matrix	calcium ion binding			autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(6)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	35		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		CTCATTTGCAGATAGAGGCGG	0.592000													52	78					0	0	0.003610	0	0
ENPP3	5169	broad.mit.edu	37	6	131971180	131971180	+	Silent	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr6:131971180G>A	ENST00000414305.1	+	4	496	c.168G>A	c.(166-168)aaG>aaA	p.K56K	ENPP3_ENST00000358229.5_Silent_p.K56K|ENPP3_ENST00000470930.1_3'UTR|ENPP3_ENST00000543135.1_Silent_p.K22K|ENPP3_ENST00000427148.2_Silent_p.K22K|ENPP3_ENST00000357639.3_Silent_p.K56K			O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 3	56	SMB 1.				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		GCTGCAGGAAGAAGTGCTTTG	0.463000													41	55					0	0	0.006230	0	0
DEPDC5	9681	broad.mit.edu	37	22	32160960	32160960	+	Splice_Site	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr22:32160960G>A	ENST00000400246.1	+	5	335		c.e5-1		DEPDC5_ENST00000266091.3_Splice_Site|DEPDC5_ENST00000400249.2_Splice_Site|DEPDC5_ENST00000382111.2_Splice_Site|DEPDC5_ENST00000382112.3_Splice_Site|DEPDC5_ENST00000536766.1_Splice_Site|DEPDC5_ENST00000400248.2_Splice_Site|DEPDC5_ENST00000382105.2_Splice_Site|DEPDC5_ENST00000535622.1_Splice_Site|DEPDC5_ENST00000400242.3_Splice_Site			O75140	DEPD5_HUMAN	DEP domain containing 5						intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						TTCTGTTTTAGAAACTATCAG	0.363000													6	88					0	0	0.001984	0	0
ASXL1	171023	broad.mit.edu	37	20	31017811	31017811	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr20:31017811C>T	ENST00000375687.4	+	8	1097	c.673C>T	c.(673-675)Cag>Tag	p.Q225*	ASXL1_ENST00000306058.5_Nonsense_Mutation_p.Q220*	NM_015338.5	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 (Drosophila)	225					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(655)|kidney(5)|large_intestine(18)|liver(1)|lung(27)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	722						CGAGGTCACCCAGGACCCTGC	0.687000			"""F, N, Mis"""		"""MDS, CMML"""								22	17					0	0	0.003330	0	0
EXT1	2131	broad.mit.edu	37	8	118842578	118842578	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr8:118842578G>A	ENST00000378204.2	-	4	1981	c.1175C>T	c.(1174-1176)aCa>aTa	p.T392I		NM_000127.2	NP_000118.2	Q16394	EXT1_HUMAN	exostosin glycosyltransferase 1	392					glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(12)|lung(10)|ovary(3)|prostate(1)|stomach(1)|urinary_tract(2)	38	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)			AGACCTGATTGTAGAAGGAAT	0.353000			"""Mis, N, F, S"""			"""exostoses, osteosarcoma"""			Langer-Giedion syndrome;Hereditary Multiple Exostoses				16	24					0	0	0.004007	0	0
KCNJ5	3762	broad.mit.edu	37	11	128782060	128782060	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr11:128782060G>C	ENST00000529694.1	+	2	1268	c.892G>C	c.(892-894)Gag>Cag	p.E298Q	KCNJ5_ENST00000338350.4_Missense_Mutation_p.E298Q|KCNJ5_ENST00000533599.1_Missense_Mutation_p.E298Q	NM_000890.3	NP_000881.3	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 5	298					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(4)|liver(2)|lung(9)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	GCATCAGGAAGAGTTTGAAGT	0.527000													49	4					0	0	0.003610	0	0
ZNF30	90075	broad.mit.edu	37	19	35434903	35434903	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:35434903G>C	ENST00000439785.1	+	5	1480	c.1036G>C	c.(1036-1038)Gaa>Caa	p.E346Q	ZNF30_ENST00000601142.1_Missense_Mutation_p.E345Q|ZNF30_ENST00000601957.1_3'UTR|ZNF30_ENST00000426813.2_Missense_Mutation_p.E264Q|ZNF30_ENST00000303586.7_Missense_Mutation_p.E346Q	NM_001099438.1	NP_001092908.1	P17039	ZNF30_HUMAN	zinc finger protein 30	345					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)	16	all_lung(56;8.38e-08)|Lung NSC(56;1.31e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)	GBM - Glioblastoma multiforme(1328;0.0265)		GAAACCTTTTGAATGTAAGGA	0.448000													54	66					0	0	0.003610	0	0
BPTF	2186	broad.mit.edu	37	17	65882426	65882426	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:65882426G>C	ENST00000321892.4	+	6	2297	c.2236G>C	c.(2236-2238)Gag>Cag	p.E746Q	BPTF_ENST00000306378.6_Intron|BPTF_ENST00000424123.3_Missense_Mutation_p.E607Q|BPTF_ENST00000335221.5_Missense_Mutation_p.E746Q			Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	746	Interaction with KEAP1.				brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			TATTCAGGAAGAGATAGGTAA	0.353000													15	39					0	0	0.002450	0	0
ACIN1	22985	broad.mit.edu	37	14	23533388	23533388	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr14:23533388C>G	ENST00000262710.1	-	12	3022	c.2695G>C	c.(2695-2697)Gag>Cag	p.E899Q	ACIN1_ENST00000397341.3_Missense_Mutation_p.E141Q|ACIN1_ENST00000605057.1_Missense_Mutation_p.E841Q|ACIN1_ENST00000557515.1_Missense_Mutation_p.E140Q|ACIN1_ENST00000457657.1_Missense_Mutation_p.E859Q|ACIN1_ENST00000555053.1_Missense_Mutation_p.E886Q|ACIN1_ENST00000357481.2_Missense_Mutation_p.E141Q|ACIN1_ENST00000338631.6_Missense_Mutation_p.E172Q	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	899					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GTCTCATCCTCAGAGATGCGA	0.567000													44	64					0	0	0.002222	0	0
ARHGAP11A	9824	broad.mit.edu	37	15	32928484	32928484	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr15:32928484G>A	ENST00000361627.3	+	12	2232	c.1510G>A	c.(1510-1512)Gaa>Aaa	p.E504K	ARHGAP11A_ENST00000565905.1_Missense_Mutation_p.E315K|ARHGAP11A_ENST00000543522.1_Missense_Mutation_p.E315K	NM_014783.3	NP_055598.1	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A	504					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		TAAGTCTGAGGAAACCTTACT	0.368000													30	26					0	0	0.002096	0	0
NIN	51199	broad.mit.edu	37	14	51259486	51259486	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr14:51259486C>A	ENST00000245441.5	-	5	569	c.379G>T	c.(379-381)Gag>Tag	p.E127*	NIN_ENST00000382043.4_Nonsense_Mutation_p.E127*|NIN_ENST00000324330.9_Nonsense_Mutation_p.E127*|NIN_ENST00000453196.1_Nonsense_Mutation_p.E127*|NIN_ENST00000530997.2_Nonsense_Mutation_p.E127*|NIN_ENST00000486200.1_5'UTR|NIN_ENST00000382041.3_Nonsense_Mutation_p.E127*|NIN_ENST00000389868.3_Nonsense_Mutation_p.E127*	NM_020921.3	NP_065972	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	127					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					TCCAGTGGCTCAATCACCGTC	0.547000			T	PDGFRB	MPD								35	50					4.62619e-21	5.50141e-21	0.004289	1	0
KIF1A	547	broad.mit.edu	37	2	241726723	241726723	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr2:241726723T>C	ENST00000498729.2	-	5	620	c.374A>G	c.(373-375)gAc>gGc	p.D125G	KIF1A_ENST00000320389.7_Missense_Mutation_p.D125G	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	125	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		AGAGAAGAGGTCCTCGCAGAG	0.657000													31	43					0	0	0.002445	0	0
ITGAE	3682	broad.mit.edu	37	17	3649140	3649140	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:3649140C>G	ENST00000263087.4	-	18	2335	c.2237G>C	c.(2236-2238)aGa>aCa	p.R746T		NM_002208.4	NP_002199.3	P38570	ITAE_HUMAN	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	746					cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		CAGACAGCTTCTTACGTCTGA	0.587000													49	6					0	0	0.003610	0	0
SHROOM3	57619	broad.mit.edu	37	4	77675497	77675497	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:77675497G>C	ENST00000296043.6	+	7	4814	c.3861G>C	c.(3859-3861)gaG>gaC	p.E1287D		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	1287					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			GCCAAGAAGAGATGCTGCCGC	0.547000													81	113					0	0	0.003610	0	0
CSE1L	1434	broad.mit.edu	37	20	47707558	47707558	+	Splice_Site	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr20:47707558G>A	ENST00000262982.2	+	21	2487	c.2364G>A	c.(2362-2364)aaG>aaA	p.K788K	CSE1L_ENST00000469700.1_3'UTR|CSE1L_ENST00000542325.1_Splice_Site_p.K571K|CSE1L_ENST00000396192.3_Splice_Site_p.K732K	NM_001256135.1|NM_001316.3	NP_001243064.1|NP_001307.2	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like (yeast)	788					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(11)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	35			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			AGTTTATCAAGAGTAAGTAAA	0.308000													12	45					0	0	0.003954	0	0
FAM189A2	9413	broad.mit.edu	37	9	71990748	71990748	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr9:71990748C>T	ENST00000257515.8	+	4	640	c.220C>T	c.(220-222)Cag>Tag	p.Q74*	FAM189A2_ENST00000455972.1_Nonsense_Mutation_p.Q74*|FAM189A2_ENST00000303068.7_5'UTR	NM_004816.3	NP_004807.3	Q15884	F1892_HUMAN	family with sequence similarity 189, member A2	74						integral to membrane				endometrium(3)|large_intestine(5)|liver(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	12						CTTTCCGGTTCAGCCCTGTAG	0.463000													57	4					0	0	0.003610	0	0
CCDC27	148870	broad.mit.edu	37	1	3669321	3669321	+	Silent	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:3669321C>G	ENST00000294600.2	+	1	360	c.276C>G	c.(274-276)ctC>ctG	p.L92L		NM_152492.2	NP_689705.2	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	92										breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(2)|lung(17)|prostate(1)|skin(2)|urinary_tract(2)	36	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		CACGCACGCTCAGCAAGTCGG	0.637000													31	23					0	0	0.002836	0	0
HERC1	8925	broad.mit.edu	37	15	63986695	63986695	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr15:63986695G>A	ENST00000443617.2	-	29	5383	c.5296C>T	c.(5296-5298)Caa>Taa	p.Q1766*	RP11-317G6.1_ENST00000559303.2_RNA	NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	1766					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						TCTACTGGTTGATAATGAACA	0.423000													32	31					0	0	0.002836	0	0
C8orf76	84933	broad.mit.edu	37	8	124253503	124253503	+	Silent	SNP	G	G	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr8:124253503G>T	ENST00000276704.4	-	1	135	c.84C>A	c.(82-84)ccC>ccA	p.P28P	C8orf76_ENST00000521310.1_5'UTR|ZHX1-C8ORF76_ENST00000357082.4_Intron	NM_032847.2	NP_116236.1	Q96K31	CH076_HUMAN	chromosome 8 open reading frame 76	28							binding			NS(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(4)	17	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			AGTAGGACGCGGGCGGTCCTG	0.736000													10	9					7.48243e-07	8.70203e-07	0.006214	1	0
BSG	682	broad.mit.edu	37	19	580761	580761	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:580761G>C	ENST00000333511.3	+	5	841	c.771G>C	c.(769-771)aaG>aaC	p.K257N	BSG_ENST00000346916.4_Missense_Mutation_p.K77N|BSG_ENST00000353555.4_Missense_Mutation_p.K141N|BSG_ENST00000545507.2_Missense_Mutation_p.K48N	NM_001728.3	NP_001719.2	P35613	BASI_HUMAN	basigin	257	Ig-like V-type.				blood coagulation|cell surface receptor linked signaling pathway|leukocyte migration|pyruvate metabolic process	Golgi membrane|integral to membrane|melanosome	lactate transmembrane transporter activity|mannose binding|protein binding			central_nervous_system(1)|endometrium(3)|lung(1)	5		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTGGTACAAGATCACTGACT	0.612000													19	38					0	0	0.007413	0	0
FAT1	2195	broad.mit.edu	37	4	187630570	187630570	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:187630570G>A	ENST00000441802.2	-	2	621	c.412C>T	c.(412-414)Cag>Tag	p.Q138*		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	138	Cadherin 1.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TCCAGCACCTGCACCCTGACC	0.418000										HNSCC(5;0.00058)			103	127					0	0	0.003610	0	0
DPEP1	1800	broad.mit.edu	37	16	89703951	89703951	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:89703951C>T	ENST00000393092.3	+	8	1135	c.844C>T	c.(844-846)Caa>Taa	p.Q282*	DPEP1_ENST00000261615.4_Nonsense_Mutation_p.Q282*|DPEP1_ENST00000421184.1_Nonsense_Mutation_p.Q282*	NM_004413.3	NP_004404.1	P16444	DPEP1_HUMAN	dipeptidase 1 (renal)	282					proteolysis	anchored to membrane|apical plasma membrane|microvillus membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity|protein binding			large_intestine(2)|lung(10)|prostate(1)|urinary_tract(1)	14		all_lung(18;0.0054)|all_hematologic(23;0.094)		BRCA - Breast invasive adenocarcinoma(80;0.0258)	Cilastatin(DB01597)	CAACCTGTCCCAAGTGGCCGG	0.577000													77	65					0	0	0.003610	0	0
SPECC1L	23384	broad.mit.edu	37	22	24717883	24717883	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr22:24717883C>T	ENST00000314328.9	+	5	1220	c.935C>T	c.(934-936)tCt>tTt	p.S312F	SPECC1L-ADORA2A_ENST00000358654.2_Missense_Mutation_p.S312F|SPECC1L_ENST00000437398.1_Missense_Mutation_p.S312F|SPECC1L_ENST00000541492.1_Missense_Mutation_p.S312F|SPECC1L_ENST00000416735.1_Intron	NM_001254733.1|NM_015330.3	NP_001241662.1|NP_056145	Q69YQ0	CYTSA_HUMAN	sperm antigen with calponin homology and coiled-coil domains 1-like	312					cell cycle|cell division					breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(6)|ovary(1)|prostate(1)|skin(3)|stomach(2)|urinary_tract(1)	27						ACTCTGACTTCTTCAGTGGAA	0.478000													45	56					0	0	0.003610	0	0
IMPACT	55364	broad.mit.edu	37	18	22025392	22025392	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr18:22025392G>C	ENST00000284202.4	+	8	771	c.630G>C	c.(628-630)aaG>aaC	p.K210N		NM_018439.3	NP_060909	Q9P2X3	IMPCT_HUMAN	impact RWD domain protein	210										endometrium(1)|large_intestine(3)|lung(9)|skin(1)|upper_aerodigestive_tract(2)	16	all_cancers(21;0.00018)|all_epithelial(16;1.5e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)					ATGAGAATAAGAAAATAGCTA	0.308000													30	47					0	0	0.002836	0	0
SLC1A1	6505	broad.mit.edu	37	9	4585317	4585317	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr9:4585317G>A	ENST00000262352.3	+	12	1570	c.1334G>A	c.(1333-1335)cGg>cAg	p.R445Q		NM_004170.5	NP_004161.4	P43005	EAA3_HUMAN	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	445					D-aspartate import|L-glutamate import|synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|pancreas(1)|skin(1)	15		Acute lymphoblastic leukemia(2;0.0359)|Breast(48;0.0457)		GBM - Glioblastoma multiforme(50;0.0124)|Lung(218;0.183)	L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)	CCCAGGGACCGGTTCAGGACC	0.507000													30	59					0	0	0.002096	0	0
PSMC2	5701	broad.mit.edu	37	7	103003152	103003152	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr7:103003152C>G	ENST00000435765.1	+	7	853	c.442C>G	c.(442-444)Caa>Gaa	p.Q148E	PSMC2_ENST00000292644.3_Missense_Mutation_p.Q148E|PSMC2_ENST00000544811.1_Missense_Mutation_p.Q11E|SLC26A5_ENST00000393735.2_Intron|SLC26A5_ENST00000339444.6_Intron|SLC26A5_ENST00000356767.4_Intron	NM_002803.3	NP_002794.1	P35998	PRS7_HUMAN	proteasome (prosome, macropain) 26S subunit, ATPase, 2	148					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding			breast(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	21						AAATAAATATCAAATTCACAT	0.333000													52	4					0	0	0.003610	0	0
SLC36A4	120103	broad.mit.edu	37	11	92916047	92916047	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr11:92916047C>G	ENST00000326402.4	-	4	414	c.284G>C	c.(283-285)aGc>aCc	p.S95T	SLC36A4_ENST00000529184.1_5'UTR	NM_152313.2	NP_689526.2	Q6YBV0	S36A4_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 4	95					L-alanine transport|proline transport|tryptophan transport	integral to membrane	symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	25		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				AAACACAAGGCTGATTGGTCC	0.328000													51	57					0	0	0.003610	0	0
STC1	6781	broad.mit.edu	37	8	23709043	23709043	+	Splice_Site	SNP	C	C	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr8:23709043C>A	ENST00000290271.2	-	3	546	c.263G>T	c.(262-264)gGa>gTa	p.G88V	STC1_ENST00000524323.1_Splice_Site_p.G19V	NM_003155.2	NP_003146.1	P52823	STC1_HUMAN	stanniocalcin 1	88					cell surface receptor linked signaling pathway|cell-cell signaling|cellular calcium ion homeostasis		hormone activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	26		Prostate(55;0.055)|Breast(100;0.116)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		GAATGCTTTTCCCTGCCATGG	0.507000													12	21					4.36969e-10	5.1271e-10	0.001855	1	0
HOXA2	3199	broad.mit.edu	37	7	27140803	27140803	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr7:27140803C>T	ENST00000222718.5	-	2	983	c.673G>A	c.(673-675)Gag>Aag	p.E225K		NM_006735.3	NP_006726.1	O43364	HXA2_HUMAN	homeobox A2	225						nucleus	sequence-specific DNA binding transcription factor activity			breast(3)|cervix(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(1)	22						TCCTCGTCCTCCTCTACTTTC	0.517000													47	44					0	0	0.003610	0	0
ASB5	140458	broad.mit.edu	37	4	177143510	177143510	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:177143510C>G	ENST00000296525.3	-	3	451	c.338G>C	c.(337-339)gGa>gCa	p.G113A	ASB5_ENST00000512254.1_Missense_Mutation_p.G60A|ASB5_ENST00000511879.1_5'UTR	NM_080874.3	NP_543150.1	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box containing 5	113					intracellular signal transduction					endometrium(2)|kidney(1)|large_intestine(9)|lung(18)|prostate(2)|skin(2)	34		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		CACGTGATCTCCAAGGCAGGC	0.423000													30	31					0	0	0.001786	0	0
KRI1	65095	broad.mit.edu	37	19	10668240	10668240	+	Silent	SNP	G	G	A	rs144674130	by1000genomes	TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:10668240G>A	ENST00000312962.6	-	16	1642	c.1623C>T	c.(1621-1623)ctC>ctT	p.L541L	KRI1_ENST00000361821.5_Silent_p.L537L	NM_023008.3	NP_075384.3	Q8N9T8	KRI1_HUMAN	KRI1 homolog (S. cerevisiae)	541										NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	26			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			CCTCAGTGCTGAGGCCAAAGT	0.602000													23	25					0	0	0.002299	0	0
MTTP	4547	broad.mit.edu	37	4	100510816	100510816	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:100510816C>G	ENST00000457717.1	+	5	666	c.410C>G	c.(409-411)tCa>tGa	p.S137*	MTTP_ENST00000265517.5_Nonsense_Mutation_p.S137*|MTTP_ENST00000511045.1_Nonsense_Mutation_p.S164*	NM_000253.2	NP_000244.2	P55157	MTP_HUMAN	microsomal triglyceride transfer protein	137	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(14)|lung(19)|ovary(4)|prostate(5)|skin(1)|urinary_tract(1)	57				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	GAGTTCTACTCATATCAAAAT	0.418000													16	18					0	0	0.007413	0	0
MBOAT7	79143	broad.mit.edu	37	19	54678031	54678031	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:54678031C>T	ENST00000245615.1	-	8	1606	c.1126G>A	c.(1126-1128)Gag>Aag	p.E376K	MBOAT7_ENST00000338624.6_Missense_Mutation_p.E303K|MBOAT7_ENST00000431666.2_Missense_Mutation_p.E303K	NM_024298.3	NP_077274.3	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain containing 7	376					phospholipid biosynthetic process	integral to membrane	acyltransferase activity			endometrium(4)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	10	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					AGCCGGCCCTCGGCAGCCAGG	0.687000													62	50					0	0	0.003610	0	0
MIB1	57534	broad.mit.edu	37	18	19345737	19345737	+	Silent	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr18:19345737C>T	ENST00000261537.6	+	2	498	c.234C>T	c.(232-234)atC>atT	p.I78I	MIB1_ENST00000578646.1_3'UTR	NM_020774.2	NP_065825.1	Q86YT6	MIB1_HUMAN	mindbomb E3 ubiquitin protein ligase 1	78					Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|ovary(5)	27			STAD - Stomach adenocarcinoma(5;0.212)			TAATAGGCATCAAGCATGATG	0.363000													29	38					0	0	0.001786	0	0
SPECC1L	23384	broad.mit.edu	37	22	24718351	24718351	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr22:24718351C>T	ENST00000314328.9	+	5	1688	c.1403C>T	c.(1402-1404)tCt>tTt	p.S468F	SPECC1L-ADORA2A_ENST00000358654.2_Missense_Mutation_p.S468F|SPECC1L_ENST00000437398.1_Missense_Mutation_p.S468F|SPECC1L_ENST00000541492.1_Missense_Mutation_p.S468F|SPECC1L_ENST00000416735.1_Intron	NM_001254733.1|NM_015330.3	NP_001241662.1|NP_056145	Q69YQ0	CYTSA_HUMAN	sperm antigen with calponin homology and coiled-coil domains 1-like	468					cell cycle|cell division					breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(6)|ovary(1)|prostate(1)|skin(3)|stomach(2)|urinary_tract(1)	27						TACTTCCGCTCTCTTCTAGAT	0.408000													65	70					0	0	0.003610	0	0
AFF3	3899	broad.mit.edu	37	2	100199373	100199373	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr2:100199373C>T	ENST00000409236.2	-	15	2792	c.2680G>A	c.(2680-2682)Gag>Aag	p.E894K	AFF3_ENST00000317233.4_Missense_Mutation_p.E894K|AFF3_ENST00000409579.1_Missense_Mutation_p.E919K|AFF3_ENST00000356421.2_Missense_Mutation_p.E919K			P51826	AFF3_HUMAN	AF4/FMR2 family, member 3						multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.E919K(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						GTTAAGTCCTCGCTGGTGTAT	0.463000													47	44					0	0	0.003214	0	0
SLC24A3	57419	broad.mit.edu	37	20	19701741	19701741	+	Missense_Mutation	SNP	A	A	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr20:19701741A>C	ENST00000328041.6	+	17	2089	c.1892A>C	c.(1891-1893)aAc>aCc	p.N631T		NM_020689.3	NP_065740.2	Q9HC58	NCKX3_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	631						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						ACTGAGTTCAACGTGTTCACC	0.582000													67	72					0	0	0.003610	0	0
RAB7A	7879	broad.mit.edu	37	3	128525358	128525358	+	Silent	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr3:128525358C>T	ENST00000265062.3	+	4	570	c.324C>T	c.(322-324)atC>atT	p.I108I	RAB7A_ENST00000482525.1_Intron|RAB7A_ENST00000485280.1_Intron	NM_004637.5	NP_004628.4	P51149	RAB7A_HUMAN	RAB7A, member RAS oncogene family	108				I -> V (in Ref. 2; AAA86640).	endocytosis|endosome to lysosome transport|epidermal growth factor catabolic process|protein transport|small GTPase mediated signal transduction	Golgi apparatus|late endosome|lysosome|melanosome|phagocytic vesicle	GDP binding|GTP binding|GTPase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|urinary_tract(1)	8				GBM - Glioblastoma multiforme(114;0.231)		AGTTTCTCATCCAGGCCAGTC	0.458000													37	42					0	0	0.005524	0	0
ANKRD39	51239	broad.mit.edu	37	2	97514175	97514175	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr2:97514175C>T	ENST00000393537.4	-	4	522	c.415G>A	c.(415-417)Gag>Aag	p.E139K		NM_016466.5	NP_057550.3	Q53RE8	ANR39_HUMAN	ankyrin repeat domain 39	139										NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)	6						TGACCCCTCTCAGCAGCCTGT	0.582000													45	39					0	0	0.003610	0	0
IGSF10	285313	broad.mit.edu	37	3	151166508	151166508	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr3:151166508C>G	ENST00000282466.3	-	4	1260	c.1261G>C	c.(1261-1263)Gat>Cat	p.D421H		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	421					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCTCTGAGATCTGCCTCTATG	0.438000													37	35					0	0	0.004289	0	0
EI24	9538	broad.mit.edu	37	11	125448904	125448904	+	Silent	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr11:125448904C>T	ENST00000278903.6	+	7	743	c.501C>T	c.(499-501)gtC>gtT	p.V167V	EI24_ENST00000343678.4_Silent_p.V167V|EI24_ENST00000530985.1_3'UTR|STT3A-AS1_ENST00000532714.1_RNA|STT3A-AS1_ENST00000530526.1_RNA	NM_004879.3	NP_004870.3	O14681	EI24_HUMAN	etoposide induced 2.4	167					apoptosis|autophagy|induction of apoptosis|negative regulation of cell growth	endoplasmic reticulum membrane|integral to membrane|nuclear membrane				large_intestine(1)|lung(9)|ovary(1)	11	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.64e-07)|OV - Ovarian serous cystadenocarcinoma(99;0.0975)		TCCCTAGTGTCAGCAAAATAA	0.443000													5	1					0	0	0.003080	0	0
MTR	4548	broad.mit.edu	37	1	237060354	237060354	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:237060354C>G	ENST00000366577.5	+	32	4041	c.3647C>G	c.(3646-3648)tCa>tGa	p.S1216*	MTR_ENST00000535889.1_Nonsense_Mutation_p.S1165*|MTR_ENST00000470570.1_3'UTR	NM_000254.2	NP_000245.2	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase	1216	AdoMet activation.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	67	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	TCAGCAGTCTCAGGCCTCTAC	0.453000													103	115					0	0	0.003610	0	0
FAM63B	54629	broad.mit.edu	37	15	59139599	59139599	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr15:59139599C>T	ENST00000559228.1	+	7	1554	c.1472C>T	c.(1471-1473)tCa>tTa	p.S491L	FAM63B_ENST00000450403.2_Missense_Mutation_p.S491L			Q8NBR6	FA63B_HUMAN	family with sequence similarity 63, member B	491										central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	15						TTCTGTGACTCAGAATTTCAT	0.393000													37	30					0	0	0.003271	0	0
RBM26	64062	broad.mit.edu	37	13	79916956	79916956	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr13:79916956G>C	ENST00000438737.2	-	17	2710	c.2270C>G	c.(2269-2271)tCa>tGa	p.S757*	RBM26_ENST00000438724.1_Nonsense_Mutation_p.S733*|RBM26_ENST00000267229.7_Nonsense_Mutation_p.S730*			Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	757					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(6)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		CTCCAGTTTTGAAATTAACAT	0.244000													19	42					0	0	0.002780	0	0
IL2RG	3561	broad.mit.edu	37	X	70327696	70327696	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chrX:70327696C>G	ENST00000374202.2	-	8	1091	c.1000G>C	c.(1000-1002)Gag>Cag	p.E334Q	IL2RG_ENST00000456850.2_Missense_Mutation_p.E144Q|IL2RG_ENST00000374188.3_Missense_Mutation_p.E63Q	NM_000206.2	NP_000197.1	P31785	IL2RG_HUMAN	interleukin 2 receptor, gamma	334					immune response|interleukin-4-mediated signaling pathway|interspecies interaction between organisms	external side of plasma membrane|integral to plasma membrane	cytokine receptor activity|interleukin-2 binding			breast(1)|endometrium(3)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|urinary_tract(1)	15	Renal(35;0.156)				Aldesleukin(DB00041)|Denileukin diftitox(DB00004)	GGGGGAATCTCACTGACGAGG	0.597000									Severe Combined Immunodeficiency, X-linked				31	0					0	0	0.001786	0	0
MUC16	94025	broad.mit.edu	37	19	9089752	9089752	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:9089752G>A	ENST00000397910.4	-	1	2266	c.2063C>T	c.(2062-2064)tCa>tTa	p.S688L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	688	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCTGAAAGCTGAGGACTGTAG	0.507000													58	50					0	0	0.003610	0	0
RYR2	6262	broad.mit.edu	37	1	237949319	237949319	+	Silent	SNP	T	T	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:237949319T>A	ENST00000366574.2	+	91	13628	c.13311T>A	c.(13309-13311)tcT>tcA	p.S4437S	RYR2_ENST00000360064.6_Silent_p.S4443S|RYR2_ENST00000609119.1_3'UTR|RYR2_ENST00000542537.1_Silent_p.S4421S	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4437	Glu-rich (acidic).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			aaACCAAATCTGAACCTGAAA	0.378000													10	5					0	0	0.006214	0	0
THSD1	55901	broad.mit.edu	37	13	52952521	52952521	+	Silent	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr13:52952521G>A	ENST00000349258.4	-	4	1969	c.1425C>T	c.(1423-1425)ttC>ttT	p.F475F	THSD1_ENST00000258613.4_Silent_p.F528F|THSD1_ENST00000544466.1_Silent_p.F149F	NM_199263.2	NP_954872.1	Q9NS62	THSD1_HUMAN	thrombospondin, type I, domain containing 1	528						extracellular region|integral to membrane|intracellular membrane-bounded organelle				breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		GGCGGTAGCTGAACAGAGGTG	0.552000													5	256					0	0	0.001168	0	0
GPS2	2874	broad.mit.edu	37	17	7216947	7216947	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:7216947G>A	ENST00000380728.2	-	7	874	c.574C>T	c.(574-576)Cag>Tag	p.Q192*	GPS2_ENST00000391950.3_Nonsense_Mutation_p.Q192*|RP11-542C16.2_ENST00000575474.1_3'UTR|GPS2_ENST00000389167.5_Nonsense_Mutation_p.Q192*			Q13227	GPS2_HUMAN	G protein pathway suppressor 2	192					cell cycle|inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter	transcriptional repressor complex	GTPase inhibitor activity|protein binding|transcription corepressor activity	p.Q192*(1)		breast(1)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(1)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(4)	24		Prostate(122;0.157)				GGTGGGGGCTGAGCAGTCCCA	0.577000											OREG0024133	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	64	5					0	0	0.003610	0	0
NLRC5	84166	broad.mit.edu	37	16	57092020	57092020	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:57092020C>G	ENST00000436936.1	+	28	4015	c.3790C>G	c.(3790-3792)Ctg>Gtg	p.L1264V	NLRC5_ENST00000262510.6_Missense_Mutation_p.L1264V|NLRC5_ENST00000308149.7_Missense_Mutation_p.L1235V|NLRC5_ENST00000539144.1_Missense_Mutation_p.L1235V|RP11-322D14.2_ENST00000562970.1_RNA			Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	1264					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				CAGATGCCTTCTGGAATGTCT	0.572000													10	12					0	0	0.000978	0	0
RPL7L1	285855	broad.mit.edu	37	6	42848633	42848633	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr6:42848633C>G	ENST00000493763.1	+	2	352	c.49C>G	c.(49-51)Ctg>Gtg	p.L17V	RPL7L1_ENST00000602561.1_Missense_Mutation_p.L17V|RPL7L1_ENST00000424341.2_Missense_Mutation_p.L17V|RPL7L1_ENST00000397415.3_3'UTR|RPL7L1_ENST00000304734.5_Missense_Mutation_p.L17V	NM_198486.2	NP_940888.2	Q6DKI1	RL7L_HUMAN	ribosomal protein L7-like 1	17					translation	large ribosomal subunit	protein binding|structural constituent of ribosome			breast(1)|endometrium(1)|large_intestine(1)|lung(3)	6	Colorectal(47;0.196)		Colorectal(64;0.00237)|all cancers(41;0.00288)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.088)			AGAAAATCTCCTGAAAAAGAG	0.453000													40	27					0	0	0.008740	0	0
CPD	1362	broad.mit.edu	37	17	28791803	28791803	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:28791803G>C	ENST00000225719.4	+	21	4190	c.4114G>C	c.(4114-4116)Gag>Cag	p.E1372Q	CPD_ENST00000543464.2_Missense_Mutation_p.E1125Q	NM_001304.4	NP_001295.2	O75976	CBPD_HUMAN	carboxypeptidase D	1372					proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(13)|skin(5)|stomach(1)|urinary_tract(1)	36						AGACACTGAAGAGGAAACATT	0.413000													57	75					0	0	0.003610	0	0
CMTM1	113540	broad.mit.edu	37	16	66603973	66603973	+	Silent	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:66603973G>A	ENST00000379500.2	+	2	634	c.567G>A	c.(565-567)ctG>ctA	p.L189L	CMTM1_ENST00000529506.1_Intron|CMTM1_ENST00000528324.1_Silent_p.L72L|CMTM1_ENST00000328020.6_Silent_p.L189L|CMTM1_ENST00000531885.1_Intron|CMTM1_ENST00000336328.6_Intron|CMTM1_ENST00000457188.2_Silent_p.L72L|CMTM1_ENST00000533953.1_Intron|CMTM1_ENST00000332695.7_Intron|CMTM1_ENST00000533666.1_Intron|CKLF-CMTM1_ENST00000527729.1_Intron|CMTM1_ENST00000535705.1_Intron	NM_052999.3|NM_181268.2	NP_443725.3|NP_851785.2	Q8IZ96	CKLF1_HUMAN	CKLF-like MARVEL transmembrane domain containing 1	72					chemotaxis	extracellular space|integral to membrane	cytokine activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)	7		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0702)|Epithelial(162;0.222)		ACCACTTGCTGACCTATTTAC	0.388000													76	101					0	0	0.003610	0	0
TRIM65	201292	broad.mit.edu	37	17	73892977	73892977	+	Silent	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:73892977G>A	ENST00000269383.3	-	1	107	c.42C>T	c.(40-42)atC>atT	p.I14I		NM_001256124.1|NM_173547.3	NP_001243053.1|NP_775818.2	Q6PJ69	TRI65_HUMAN	tripartite motif containing 65	14						intracellular	zinc ion binding			endometrium(1)|kidney(1)|lung(5)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	12			Epithelial(20;7.53e-06)|all cancers(21;9.11e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00092)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCCCCAGGCAGATGGCGCAGG	0.726000													5	8					0	0	0.001168	0	0
ROBO2	6092	broad.mit.edu	37	3	77614213	77614213	+	Silent	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr3:77614213G>A	ENST00000461745.1	+	12	2691	c.1791G>A	c.(1789-1791)gcG>gcA	p.A597A	ROBO2_ENST00000332191.8_Silent_p.A597A|ROBO2_ENST00000487694.3_Silent_p.A613A	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	597	Fibronectin type-III 1.				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		TGGTCAGAGCGATCAACCCCC	0.498000													57	70					0	0	0.003610	0	0
CXorf38	159013	broad.mit.edu	37	X	40506339	40506339	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chrX:40506339G>A	ENST00000327877.5	-	2	297	c.271C>T	c.(271-273)Cat>Tat	p.H91Y	CXorf38_ENST00000378421.1_5'UTR|CXorf38_ENST00000378426.1_5'UTR|CXorf38_ENST00000440784.2_Intron|CXorf38_ENST00000378418.2_Missense_Mutation_p.H91Y	NM_144970.2	NP_659407.1	Q8TB03	CX038_HUMAN	chromosome X open reading frame 38	91										NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(1)	12						CTGTTGACATGATGTCTCAAA	0.632000													27	0					0	0	0.005443	0	0
IL2RG	3561	broad.mit.edu	37	X	70327726	70327726	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chrX:70327726C>G	ENST00000374202.2	-	8	1061	c.970G>C	c.(970-972)Gac>Cac	p.D324H	IL2RG_ENST00000456850.2_Missense_Mutation_p.D134H|IL2RG_ENST00000374188.3_Missense_Mutation_p.D53H	NM_000206.2	NP_000197.1	P31785	IL2RG_HUMAN	interleukin 2 receptor, gamma	324					immune response|interleukin-4-mediated signaling pathway|interspecies interaction between organisms	external side of plasma membrane|integral to plasma membrane	cytokine receptor activity|interleukin-2 binding			breast(1)|endometrium(3)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|urinary_tract(1)	15	Renal(35;0.156)				Aldesleukin(DB00041)|Denileukin diftitox(DB00004)	TCACTGTAGTCTGGCTGCAGA	0.577000									Severe Combined Immunodeficiency, X-linked				36	0					0	0	0.003271	0	0
TNS3	64759	broad.mit.edu	37	7	47453569	47453569	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr7:47453569G>C	ENST00000398879.1	-	12	979	c.613C>G	c.(613-615)Caa>Gaa	p.Q205E	TNS3_ENST00000355730.3_Missense_Mutation_p.Q205E|TNS3_ENST00000458317.2_Missense_Mutation_p.Q205E|TNS3_ENST00000311160.9_Missense_Mutation_p.Q205E|TNS3_ENST00000442536.2_Missense_Mutation_p.Q205E			Q68CZ2	TENS3_HUMAN	tensin 3	205	C2 tensin-type.					focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						TGCATGGCTTGGTAGAGCTTC	0.552000													61	84					0	0	0.003610	0	0
TAAR6	319100	broad.mit.edu	37	6	132891943	132891943	+	Silent	SNP	C	C	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr6:132891943C>A	ENST00000275198.1	+	1	483	c.483C>A	c.(481-483)ctC>ctA	p.L161L		NM_175067.1	NP_778237.1	Q96RI8	TAAR6_HUMAN	trace amine associated receptor 6	161						plasma membrane	G-protein coupled receptor activity			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(19)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.006)|GBM - Glioblastoma multiforme(226;0.00792)		TCCTGCCCCTCATGTACAGCG	0.502000													155	154					2.98797e-67	3.65196e-67	0.003610	1	0
ST7	7982	broad.mit.edu	37	7	116849888	116849888	+	Silent	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr7:116849888G>A	ENST00000265437.5	+	13	1516	c.1302G>A	c.(1300-1302)ctG>ctA	p.L434L	ST7_ENST00000393451.3_Silent_p.L411L|ST7_ENST00000422922.1_Silent_p.L365L|ST7_ENST00000393447.4_Silent_p.L391L|ST7_ENST00000393444.3_Silent_p.L368L|ST7_ENST00000393443.1_Silent_p.L361L|ST7_ENST00000323984.3_Silent_p.L434L|ST7_ENST00000393449.1_Silent_p.L434L|ST7_ENST00000393446.2_Silent_p.L411L|ST7_ENST00000432298.1_Silent_p.L388L	NM_021908.2	NP_068708.1	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7	434						integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(1)	21	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		AACATATCCTGAAGAGAGGAG	0.388000													4	33					0	0	0.000248	0	0
PRMT5	10419	broad.mit.edu	37	14	23398498	23398498	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr14:23398498C>T	ENST00000324366.8	-	1	296	c.73G>A	c.(73-75)Gaa>Aaa	p.E25K	PRMT5_ENST00000538452.1_5'UTR|PRMT5_ENST00000397440.4_5'UTR|PRMT5_ENST00000397441.2_5'UTR|PRMT5_ENST00000553641.1_5'UTR|PRMT5_ENST00000553897.1_Missense_Mutation_p.E25K|PRMT5_ENST00000216350.8_5'UTR	NM_006109.3	NP_006100.2	O14744	ANM5_HUMAN	protein arginine methyltransferase 5	25					cell proliferation|histone H4-R3 methylation|ncRNA metabolic process|regulation of mitosis|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	histone-arginine N-methyltransferase activity|protein binding|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			endometrium(4)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	25	all_cancers(95;2.76e-05)			GBM - Glioblastoma multiforme(265;0.0126)		TCAGCTATTTCGGGGACGCAA	0.682000													19	18					0	0	0.007413	0	0
WDR1	9948	broad.mit.edu	37	4	10100690	10100690	+	Silent	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:10100690G>A	ENST00000382452.2	-	4	585	c.303C>T	c.(301-303)ttC>ttT	p.F101F	WDR1_ENST00000499869.2_Silent_p.F101F|WDR1_ENST00000502702.1_Intron|WDR1_ENST00000382451.2_Intron	NM_017491.3	NP_059830.1	O75083	WDR1_HUMAN	WD repeat domain 1	101					platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			endometrium(3)|lung(5)|ovary(2)|pancreas(1)|urinary_tract(1)	12				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		TCTTCCCAGCGAAAGGCTGGT	0.577000													74	75					0	0	0.003610	0	0
TNFAIP8L3	388121	broad.mit.edu	37	15	51397239	51397239	+	Silent	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr15:51397239G>A	ENST00000327536.5	-	1	234	c.135C>T	c.(133-135)atC>atT	p.I45I	RP11-108K3.1_ENST00000559909.1_lincRNA	NM_207381.2	NP_997264.2	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein 8-like 3	45										endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	11				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)		AAGATAAGGGGATGAGTCTTG	0.532000													14	104					0	0	0.002780	0	0
TRPC3	7222	broad.mit.edu	37	4	122831316	122831316	+	Silent	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:122831316G>A	ENST00000264811.5	-	5	1984	c.1566C>T	c.(1564-1566)ttC>ttT	p.F522F	TRPC3_ENST00000513531.1_Silent_p.F467F|TRPC3_ENST00000379645.3_Silent_p.F595F	NM_003305.2	NP_003296.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	510					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						TACCATAAGTGAAATACTGTA	0.438000													31	56					0	0	0.002096	0	0
ZNF791	163049	broad.mit.edu	37	19	12739532	12739532	+	Silent	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:12739532C>T	ENST00000343325.4	+	4	1351	c.1189C>T	c.(1189-1191)Cta>Tta	p.L397L	ZNF490_ENST00000465656.1_Intron|ZNF791_ENST00000446165.1_3'UTR|ZNF791_ENST00000540038.1_Silent_p.L288L|ZNF791_ENST00000458122.3_Silent_p.L365L	NM_153358.2	NP_699189.2	Q3KP31	ZN791_HUMAN	zinc finger protein 791	397					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(5)|lung(6)|ovary(2)|prostate(3)	19						CAATTATCCTCTAGATTTGAA	0.363000													48	64					0	0	0.003610	0	0
CATSPERG	57828	broad.mit.edu	37	19	38853103	38853103	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:38853103G>C	ENST00000409235.3	+	19	2360	c.2245G>C	c.(2245-2247)Gag>Cag	p.E749Q	CATSPERG_ENST00000410018.1_Missense_Mutation_p.E709Q|CATSPERG_ENST00000215069.4_3'UTR|AC005625.1_ENST00000590304.1_RNA	NM_021185.4	NP_067008.3	Q6ZRH7	CTSRG_HUMAN	catsper channel auxiliary subunit gamma	749					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|pancreas(2)|prostate(6)|skin(3)|stomach(1)|urinary_tract(2)	40						CTACAACCTCGAGTCCGCGTA	0.582000													36	54					0	0	0.003271	0	0
CSE1L	1434	broad.mit.edu	37	20	47707529	47707529	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr20:47707529C>T	ENST00000262982.2	+	21	2458	c.2335C>T	c.(2335-2337)Cag>Tag	p.Q779*	CSE1L_ENST00000469700.1_3'UTR|CSE1L_ENST00000542325.1_Nonsense_Mutation_p.Q562*|CSE1L_ENST00000396192.3_Nonsense_Mutation_p.Q723*	NM_001256135.1|NM_001316.3	NP_001243064.1|NP_001307.2	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like (yeast)	779					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(11)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	35			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			CCAGAGACTTCAGAATTCCAA	0.303000													20	56					0	0	0.001786	0	0
POTEM	641455	broad.mit.edu	37	14	20010235	20010235	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr14:20010235A>G	ENST00000551509.1	-	5	974	c.923T>C	c.(922-924)gTt>gCt	p.V308A	RP11-244H18.1_ENST00000547584.1_lincRNA	NM_001145442.1	NP_001138914.1	A6NI47	POTEM_HUMAN	POTE ankyrin domain family, member M	308										endometrium(4)|kidney(1)|lung(4)	9						AAGTATGAGAACAGTTCTAAA	0.368000													4	56					0	0	0.000248	0	0
HMCN1	83872	broad.mit.edu	37	1	186062644	186062644	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:186062644G>C	ENST00000271588.4	+	66	10268	c.10039G>C	c.(10039-10041)Gat>Cat	p.D3347H	HMCN1_ENST00000367492.2_Missense_Mutation_p.D3347H	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	3347	Ig-like C2-type 32.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						GGGTAATAAAGATGAAGCAGA	0.383000													62	62					0	0	0.003610	0	0
PCDHB14	56122	broad.mit.edu	37	5	140604577	140604577	+	Silent	SNP	C	C	A	rs142260227		TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr5:140604577C>A	ENST00000239449.4	+	1	1500	c.1500C>A	c.(1498-1500)ctC>ctA	p.L500L	PCDHB14_ENST00000515856.2_Silent_p.L347L	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		500	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACCTGCCCCTCGCCTCCTTGG	0.652000													93	91					3.06722e-38	3.73154e-38	0.003610	1	0
ZPBP	11055	broad.mit.edu	37	7	50023061	50023061	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr7:50023061G>A	ENST00000046087.2	-	7	907	c.838C>T	c.(838-840)Cgt>Tgt	p.R280C	ZPBP_ENST00000491129.1_5'UTR|ZPBP_ENST00000419417.1_Missense_Mutation_p.R279C	NM_001159878.1|NM_007009.2	NP_001153350.1|NP_008940.2	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein	280					binding of sperm to zona pellucida	extracellular region				NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(3)	29	Glioma(55;0.08)|all_neural(89;0.245)					TGTTCTGCACGTCTGCCAAGA	0.323000													26	20					0	0	0.003330	0	0
DNAH9	1770	broad.mit.edu	37	17	11572854	11572854	+	Silent	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:11572854G>A	ENST00000262442.4	+	17	3164	c.3096G>A	c.(3094-3096)ggG>ggA	p.G1032G	DNAH9_ENST00000454412.2_Silent_p.G1032G	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9		Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TGCTGTACGGGCACATCCTCA	0.517000													4	91					0	0	0.001168	0	0
MIR622	693207	broad.mit.edu	37	13	90883490	90883490	+	RNA	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr13:90883490C>G	ENST00000385123.1	+	0	55					NR_030754.1																						CCACAGTGGTCATCACACAGT	0.522000													16	26					0	0	0.004007	0	0
BBS12	166379	broad.mit.edu	37	4	123664339	123664339	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:123664339G>A	ENST00000542236.1	+	3	1673	c.1292G>A	c.(1291-1293)cGg>cAg	p.R431Q	BBS12_ENST00000314218.3_Missense_Mutation_p.R431Q	NM_001178007.1	NP_001171478.1	Q6ZW61	BBS12_HUMAN	Bardet-Biedl syndrome 12	431					cellular protein metabolic process	cilium	ATP binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(6)|ovary(2)|prostate(4)	21						AACAGTAAGCGGTTGGTAATC	0.443000									Bardet-Biedl syndrome				50	44					0	0	0.003610	0	0
NOC3L	64318	broad.mit.edu	37	10	96106204	96106204	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr10:96106204G>C	ENST00000371361.3	-	11	1467	c.1367C>G	c.(1366-1368)tCt>tGt	p.S456C	NOC3L_ENST00000371350.1_Missense_Mutation_p.S456C|NOC3L_ENST00000543788.1_Missense_Mutation_p.S194C	NM_022451.9	NP_071896.8	Q8WTT2	NOC3L_HUMAN	nucleolar complex associated 3 homolog (S. cerevisiae)	456						nuclear speck|nucleolus	binding			endometrium(3)|large_intestine(17)|lung(5)|ovary(1)|skin(2)|stomach(1)	29		Colorectal(252;0.0897)				TCTTGATAGAGATTTTCTCTT	0.269000													18	41					0	0	0.007413	0	0
ZNF461	92283	broad.mit.edu	37	19	37129762	37129762	+	Silent	SNP	T	T	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:37129762T>C	ENST00000588268.1	-	6	1712	c.1485A>G	c.(1483-1485)aaA>aaG	p.K495K	ZNF461_ENST00000360357.4_Silent_p.K472K|ZNF461_ENST00000540605.2_5'UTR	NM_153257.2	NP_694989.2	Q8TAF7	ZN461_HUMAN	zinc finger protein 461	495					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|prostate(1)|urinary_tract(2)	29	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			ATTCATAGGGTTTCTCACCAG	0.393000													15	68					0	0	0.002450	0	0
BMS1P20	96610	broad.mit.edu	37	22	22661208	22661208	+	RNA	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr22:22661208C>T	ENST00000426066.1	+	0	300					NR_027293.1																						CTGAATCATGCAGAATTTGAA	0.408000													5	41					0	0	0.001168	0	0
KIF5B	3799	broad.mit.edu	37	10	32311875	32311875	+	Silent	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr10:32311875C>T	ENST00000302418.4	-	16	2272	c.1815G>A	c.(1813-1815)gtG>gtA	p.V605V		NM_004521.2	NP_004512.1	P33176	KINH_HUMAN	kinesin family member 5B	605					stress granule disassembly|vesicle transport along microtubule	kinesin complex|microtubule|perinuclear region of cytoplasm|vesicle	ATP binding|microtubule binding|microtubule motor activity		KIF5B/ALK(8)|KIF5B/RET(79)	NS(2)|breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(1)|prostate(1)	35		Prostate(175;0.0137)				TGCAACGTTTCACCATGGTTT	0.403000			T	"""RET, ALK"""	NSCLC								22	31					0	0	0.001523	0	0
OR2V2	285659	broad.mit.edu	37	5	180582343	180582343	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr5:180582343C>T	ENST00000328275.1	+	1	401	c.401C>T	c.(400-402)cCc>cTc	p.P134L		NM_206880.1	NP_996763.1	Q96R30	OR2V2_HUMAN	olfactory receptor, family 2, subfamily V, member 2	134					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20	all_cancers(89;8.26e-06)|all_epithelial(37;1.02e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.0103)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0652)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTTCACTATCCCATCCTCATG	0.502000													56	72					0	0	0.003610	0	0
TRIM7	81786	broad.mit.edu	37	5	180625764	180625764	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr5:180625764G>C	ENST00000393315.1	-	5	987	c.290C>G	c.(289-291)tCt>tGt	p.S97C	CTC-338M12.6_ENST00000502812.2_RNA|TRIM7_ENST00000422067.2_Missense_Mutation_p.S97C|TRIM7_ENST00000361809.3_Missense_Mutation_p.S97C|TRIM7_ENST00000393319.3_Missense_Mutation_p.S123C|TRIM7_ENST00000274773.7_Missense_Mutation_p.S305C|CTC-338M12.6_ENST00000512508.1_RNA|CTC-338M12.6_ENST00000509080.1_RNA	NM_203296.1	NP_976041.1	Q9C029	TRIM7_HUMAN	tripartite motif containing 7	305						cytoplasm|nucleus	zinc ion binding	p.S305C(1)		NS(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(2)|skin(1)|stomach(1)	17	all_cancers(89;6.03e-06)|all_epithelial(37;7.1e-07)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000172)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;2e-06)|Epithelial(171;1.35e-05)|OV - Ovarian serous cystadenocarcinoma(192;0.000128)|Kidney(146;0.0674)|GBM - Glioblastoma multiforme(465;0.0802)		CTTCATCTCAGAAGAGACTGT	0.527000													15	22					0	0	0.004007	0	0
BROX	148362	broad.mit.edu	37	1	222902115	222902115	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:222902115A>G	ENST00000340934.5	+	9	1107	c.701A>G	c.(700-702)tAt>tGt	p.Y234C	BROX_ENST00000537020.1_Missense_Mutation_p.Y234C|BROX_ENST00000539697.1_Missense_Mutation_p.Y202C	NM_144695.2	NP_653296.2	Q5VW32	BROX_HUMAN	BRO1 domain and CAAX motif containing	234	BRO1.					membrane				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|stomach(1)	14						GAGCCTGCATATTCTGCCAAA	0.318000													22	25					0	0	0.002780	0	0
FGFR3	2261	broad.mit.edu	37	4	1803568	1803568	+	Missense_Mutation	SNP	C	C	G	rs121913483		TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:1803568C>G	ENST00000340107.4	+	7	1002	c.746C>G	c.(745-747)tCc>tGc	p.S249C	FGFR3_ENST00000352904.1_Missense_Mutation_p.S249C|FGFR3_ENST00000412135.2_Missense_Mutation_p.S249C|FGFR3_ENST00000440486.2_Missense_Mutation_p.S249C|FGFR3_ENST00000474521.1_3'UTR|FGFR3_ENST00000481110.2_Missense_Mutation_p.S249C|FGFR3_ENST00000260795.2_Missense_Mutation_p.S249C	NM_001163213.1	NP_001156685.1	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3	249			S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1204)|p.R248_S249del(1)		NS(1)|central_nervous_system(5)|cervix(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(40)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(9)|skin(339)|soft_tissue(4)|testis(2)|upper_aerodigestive_tract(58)|urinary_tract(2607)	3091		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.736000		1	"""Mis, T"""	"""IGH@, ETV6"""	"""bladder, MM, T-cell lymphoma"""		"""Hypochondroplasia, Thanatophoric dysplasia"""		Saethre-Chotzen syndrome;Muenke syndrome				16	19					0	0	0.001523	0	0
ANP32E	81611	broad.mit.edu	37	1	150198965	150198965	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:150198965G>A	ENST00000314136.8	-	5	1025	c.656C>T	c.(655-657)tCa>tTa	p.S219L	ANP32E_ENST00000369114.5_Intron|ANP32E_ENST00000369115.2_Missense_Mutation_p.S87L|ANP32E_ENST00000436748.2_Missense_Mutation_p.S178L|ANP32E_ENST00000533654.1_Missense_Mutation_p.H164Y|ANP32E_ENST00000369119.3_Missense_Mutation_p.S171L|ANP32E_ENST00000369116.4_Missense_Mutation_p.S87L	NM_001136478.2|NM_001280559.1|NM_030920.3	NP_001129950.1|NP_001267488.1|NP_112182.1	Q9BTT0	AN32E_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	219	Asp/Glu-rich (highly acidic).					cytoplasmic membrane-bounded vesicle|nucleus	phosphatase inhibitor activity			breast(3)|endometrium(3)|lung(7)|skin(1)|urinary_tract(1)	15	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CATTAAGTATGAGAGGCCCAC	0.413000													43	52					0	0	0.003610	0	0
DSCR3	10311	broad.mit.edu	37	21	38600636	38600636	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr21:38600636G>A	ENST00000288304.5	-	7	1210	c.418C>T	c.(418-420)Caa>Taa	p.Q140*	AP001432.14_ENST00000440629.1_lincRNA|DSCR3_ENST00000398998.1_Silent_p.L134L|DSCR3_ENST00000399000.3_5'UTR|DSCR3_ENST00000476950.1_Silent_p.L155L|DSCR3_ENST00000399001.1_Silent_p.L57L|DSCR3_ENST00000309117.6_Silent_p.L182L|DSCR3_ENST00000539844.1_Silent_p.L105L			O14972	DSCR3_HUMAN	Down syndrome critical region gene 3	180					vacuolar transport	nucleus|retromer complex				endometrium(2)|kidney(1)|large_intestine(3)|lung(3)	9						TTGTTGAGTTGAGATGTCCTC	0.507000													28	39					0	0	0.001786	0	0
RAD23A	5886	broad.mit.edu	37	19	13059906	13059906	+	Silent	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:13059906G>A	ENST00000586534.1	+	6	673	c.612G>A	c.(610-612)ggG>ggA	p.G204G	RAD23A_ENST00000588826.2_3'UTR|RAD23A_ENST00000592268.1_Silent_p.G204G|RAD23A_ENST00000541222.1_Silent_p.G39G|RAD23A_ENST00000316856.3_Silent_p.G204G			P54725	RD23A_HUMAN	RAD23 homolog A (S. cerevisiae)	204					interspecies interaction between organisms|nucleotide-excision repair|positive regulation of viral genome replication|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)|skin(1)	12						GAATTCCTGGGAGCCCCGAGC	0.637000								Nucleotide excision repair (NER)					7	8					0	0	0.001984	0	0
BFAR	51283	broad.mit.edu	37	16	14749055	14749055	+	Silent	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:14749055C>T	ENST00000261658.2	+	5	1048	c.771C>T	c.(769-771)ctC>ctT	p.L257L	BFAR_ENST00000563971.1_Silent_p.L132L|BFAR_ENST00000426842.2_Silent_p.L129L	NM_016561.2	NP_057645.1	Q9NZS9	BFAR_HUMAN	bifunctional apoptosis regulator	257					anti-apoptosis|apoptosis	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	structural molecule activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|skin(1)	11						CCCAGAATCTCTGGGAATATA	0.343000													46	53					0	0	0.002222	0	0
PNKP	11284	broad.mit.edu	37	19	50370414	50370414	+	Silent	SNP	A	A	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:50370414A>G	ENST00000322344.3	-	2	157	c.48T>C	c.(46-48)ccT>ccC	p.P16P	PNKP_ENST00000596014.1_Silent_p.P16P|PNKP_ENST00000600910.1_Silent_p.P16P|PNKP_ENST00000600573.1_Silent_p.P16P|PNKP_ENST00000595792.1_5'UTR	NM_007254.3	NP_009185.2	Q96T60	PNKP_HUMAN	polynucleotide kinase 3'-phosphatase	16					DNA damage response, detection of DNA damage|DNA-dependent DNA replication|nucleotide-excision repair, DNA damage removal|response to oxidative stress|response to radiation	nucleolus	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|damaged DNA binding|double-stranded DNA binding|endonuclease activity|nucleotide kinase activity|polynucleotide 3'-phosphatase activity|protein binding	p.P16P(8)		breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|urinary_tract(1)	19		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0118)|OV - Ovarian serous cystadenocarcinoma(262;0.0134)		GCGCTCCCCCAGGGGGGCTCT	0.721000								Other BER factors					7	23					0	0	0.001368	0	0
PLEKHM1P	440456	broad.mit.edu	37	17	62796727	62796727	+	RNA	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:62796727G>A	ENST00000582986.1	-	0	1193					NR_024386.1																						TCCTCCTGCTGAGGCCGGACC	0.667000													32	61					0	0	0.001786	0	0
NLRP3	114548	broad.mit.edu	37	1	247607346	247607346	+	Silent	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:247607346C>G	ENST00000366497.2	+	7	3351	c.2571C>G	c.(2569-2571)ctC>ctG	p.L857L	NLRP3_ENST00000336119.3_Silent_p.L914L|NLRP3_ENST00000391827.2_Silent_p.L857L|NLRP3_ENST00000391828.3_Silent_p.L914L|NLRP3_ENST00000348069.2_Silent_p.L800L|NLRP3_ENST00000366496.2_Silent_p.L857L	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	914					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			ATCAGAATCTCACGCACCTTT	0.517000													34	31					0	0	0.003271	0	0
MACF1	23499	broad.mit.edu	37	1	39550081	39550081	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:39550081C>T	ENST00000567887.1	+	1	348	c.191C>T	c.(190-192)cCt>cTt	p.P64L	MACF1_ENST00000602421.1_Missense_Mutation_p.P64L|MACF1_ENST00000317713.7_Missense_Mutation_p.P64L|MACF1_ENST00000484793.1_Missense_Mutation_p.P64L|MACF1_ENST00000539005.1_Missense_Mutation_p.P64L|MACF1_ENST00000545844.1_Missense_Mutation_p.P64L|MACF1_ENST00000372915.3_Missense_Mutation_p.P64L|MACF1_ENST00000361689.2_Missense_Mutation_p.P64L			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	64	Actin-binding.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GTGCTGGACCCTGCAGAGCGT	0.632000													19	20					0	0	0.008871	0	0
ZDHHC21	340481	broad.mit.edu	37	9	14674276	14674276	+	Silent	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr9:14674276G>A	ENST00000380916.4	-	4	529	c.63C>T	c.(61-63)gtC>gtT	p.V21V		NM_178566.4	NP_848661.1	Q8IVQ6	ZDH21_HUMAN	zinc finger, DHHC-type containing 21						nitric oxide metabolic process|regulation of nitric-oxide synthase activity	Golgi membrane|integral to membrane	palmitoyltransferase activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(2)|skin(1)	9				GBM - Glioblastoma multiforme(50;4.31e-06)		ACCAAACAAAGACAATCAAAC	0.378000													3	45					0	0	0.004672	0	0
GDF9	2661	broad.mit.edu	37	5	132200111	132200111	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr5:132200111C>T	ENST00000378673.2	-	2	981	c.115G>A	c.(115-117)Gag>Aag	p.E39K	GDF9_ENST00000296875.2_Missense_Mutation_p.E39K|GDF9_ENST00000464378.1_Intron			O60383	GDF9_HUMAN	growth differentiation factor 9	39					female gamete generation|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			NS(1)|breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	22		all_cancers(142;0.105)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GATTCCAACTCAGCACTAGCA	0.502000													56	61					0	0	0.003610	0	0
NUTM2B-AS1	101060691	broad.mit.edu	37	10	81443300	81443300	+	RNA	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr10:81443300C>G	ENST00000600376.1	-	0	54				RP11-119F19.2_ENST00000596088.1_RNA																							TCAACACCCTCACGTCCAACA	0.567000													8	5					0	0	0.003080	0	0
SLC43A2	124935	broad.mit.edu	37	17	1478943	1478943	+	Silent	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:1478943G>C	ENST00000301335.5	-	14	1753	c.1665C>G	c.(1663-1665)ctC>ctG	p.L555L	SLC43A2_ENST00000571650.1_Silent_p.L559L|SLC43A2_ENST00000412517.3_Silent_p.L418L|SLC43A2_ENST00000382147.4_Silent_p.L559L	NM_001284498.1|NM_001284499.1	NP_001271427.1|NP_001271428.1	Q8N370	LAT4_HUMAN	solute carrier family 43 (amino acid system L transporter), member 2						cellular nitrogen compound metabolic process|ion transport	integral to membrane|plasma membrane				endometrium(4)|large_intestine(4)|liver(1)|lung(2)|upper_aerodigestive_tract(1)	12				UCEC - Uterine corpus endometrioid carcinoma (25;0.0883)		TTTTGAGGAAGAGTTTGTCAT	0.617000													10	1					0	0	0.003163	0	0
CHST6	4166	broad.mit.edu	37	16	75512780	75512780	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:75512780C>T	ENST00000332272.4	-	3	1126	c.947G>A	c.(946-948)cGc>cAc	p.R316H	RP11-77K12.4_ENST00000530512.3_RNA|CHST6_ENST00000390664.2_Missense_Mutation_p.R316H	NM_021615.4	NP_067628.1	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6	316					keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						GAAGGCTTCGCGGCGCGCACC	0.627000													40	46					0	0	0.005524	0	0
TMEM68	137695	broad.mit.edu	37	8	56675387	56675387	+	Silent	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr8:56675387G>C	ENST00000434581.2	-	3	331	c.132C>G	c.(130-132)ctC>ctG	p.L44L	TMEM68_ENST00000519784.1_Intron|TMEM68_ENST00000521229.1_Silent_p.L44L|TMEM68_ENST00000523073.1_Intron|TMEM68_ENST00000522576.1_Silent_p.L44L|TMEM68_ENST00000334667.2_Silent_p.L44L			Q96MH6	TMM68_HUMAN	transmembrane protein 68	44						integral to membrane	acyltransferase activity			NS(1)|kidney(1)|lung(2)|ovary(1)|skin(1)	6			Epithelial(17;0.000361)|all cancers(17;0.00326)			AAACCCACAAGAGATAGTTTG	0.338000													16	27					0	0	0.004990	0	0
ATP6V0A1	535	broad.mit.edu	37	17	40618453	40618453	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr17:40618453C>G	ENST00000343619.4	+	3	247	c.124C>G	c.(124-126)Cca>Gca	p.P42A	ATP6V0A1_ENST00000537728.1_Missense_Mutation_p.P42A|ATP6V0A1_ENST00000546249.1_Missense_Mutation_p.P42A|ATP6V0A1_ENST00000585525.1_Missense_Mutation_p.P42A|ATP6V0A1_ENST00000544137.1_Intron|ATP6V0A1_ENST00000264649.6_Missense_Mutation_p.P42A|ATP6V0A1_ENST00000393829.2_Missense_Mutation_p.P42A	NM_001130021.1	NP_001123493.1	Q93050	VPP1_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a1	42					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytoplasmic vesicle membrane|endosome membrane|Golgi apparatus|integral to membrane|melanosome|nucleus|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|urinary_tract(3)	26		all_cancers(22;1.18e-05)|Breast(137;0.000105)|all_epithelial(22;0.000254)		BRCA - Breast invasive adenocarcinoma(366;0.137)		TCAGTTAAATCCAGATGTGAA	0.318000													26	24					0	0	0.005443	0	0
RMND5A	64795	broad.mit.edu	37	2	86992260	86992260	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr2:86992260G>A	ENST00000283632.4	+	5	1127	c.632G>A	c.(631-633)cGa>cAa	p.R211Q		NM_022780.3	NP_073617.1	Q9H871	RMD5A_HUMAN	required for meiotic nuclear division 5 homolog A (S. cerevisiae)	211										kidney(1)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	17						ACAAATCAGCGAGAGGCATTA	0.368000													38	39					0	0	0.005524	0	0
PPRC1	23082	broad.mit.edu	37	10	103897653	103897653	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr10:103897653C>T	ENST00000278070.2	+	2	239	c.200C>T	c.(199-201)tCt>tTt	p.S67F	PPRC1_ENST00000413464.2_Missense_Mutation_p.S67F	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	67					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GTCAGTCTCTCTCGGCTGGGC	0.562000													21	26					0	0	0.001523	0	0
CNTN6	27255	broad.mit.edu	37	3	1424976	1424976	+	Splice_Site	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr3:1424976G>C	ENST00000446702.2	+	19	3028		c.e19-1		CNTN6_ENST00000539053.1_Splice_Site|CNTN6_ENST00000350110.2_Splice_Site			Q9UQ52	CNTN6_HUMAN	contactin 6						axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		CTGGATGGTAGAACCTCAACT	0.428000													91	135					0	0	0.003610	0	0
SVILP1	645954	broad.mit.edu	37	10	30987346	30987346	+	RNA	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr10:30987346G>C	ENST00000435645.1	+	0	479																											AGCCATAATAGAAACTAACTG	0.428000													3	54					0	0	0.004672	0	0
ESYT1	23344	broad.mit.edu	37	12	56536837	56536837	+	Silent	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr12:56536837C>G	ENST00000394048.5	+	28	3288	c.3024C>G	c.(3022-3024)ccC>ccG	p.P1008P	ESYT1_ENST00000541590.1_Silent_p.P1018P|ESYT1_ENST00000267113.4_Silent_p.P1018P	NM_001184796.1|NM_015292.2	NP_001171725.1|NP_056107.1	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	1008	C2 5.					integral to membrane				breast(2)|endometrium(2)|large_intestine(4)|lung(10)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	28						CTCCTGATCCCTATGTGTCAC	0.522000													75	85					0	0	0.003610	0	0
PKMYT1	9088	broad.mit.edu	37	16	3026840	3026840	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:3026840G>T	ENST00000431515.2	-	3	588	c.203C>A	c.(202-204)cCt>cAt	p.P68H	PKMYT1_ENST00000574385.1_Missense_Mutation_p.P59H|PKMYT1_ENST00000573944.1_Missense_Mutation_p.P59H|PKMYT1_ENST00000440027.2_Missense_Mutation_p.P68H|PKMYT1_ENST00000574730.1_Intron|PKMYT1_ENST00000262300.8_Missense_Mutation_p.P68H			Q99640	PMYT1_HUMAN	protein kinase, membrane associated tyrosine/threonine 1	68	Pro-rich.				G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis	endoplasmic reticulum membrane|Golgi membrane|membrane fraction|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	10						GGTCCGAGGAGGGAAGAGGCG	0.692000													5	4					0.000602214	0.000694256	0.000602	1	0
ARHGAP35	2909	broad.mit.edu	37	19	47423517	47423517	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:47423517C>T	ENST00000404338.3	+	1	1585	c.1585C>T	c.(1585-1587)Cga>Tga	p.R529*		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	529	FF 4.				axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity	p.R529*(2)									AGAGGAACAGCGATTTAAAGC	0.443000													74	102					0	0	0.003610	0	0
YY1AP1	55249	broad.mit.edu	37	1	155629952	155629952	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:155629952C>G	ENST00000368340.5	-	10	2211	c.2103G>C	c.(2101-2103)caG>caC	p.Q701H	YY1AP1_ENST00000311573.5_Missense_Mutation_p.Q552H|YY1AP1_ENST00000535662.1_Missense_Mutation_p.Q429H|YY1AP1_ENST00000361831.5_Missense_Mutation_p.Q572H|MSTO1_ENST00000538143.1_Intron|YY1AP1_ENST00000355499.4_Missense_Mutation_p.Q583H|YY1AP1_ENST00000368330.2_Missense_Mutation_p.Q583H|YY1AP1_ENST00000404643.1_Missense_Mutation_p.Q563H|YY1AP1_ENST00000347088.5_Missense_Mutation_p.Q583H|MSTO1_ENST00000452804.2_Intron|YY1AP1_ENST00000359205.5_Missense_Mutation_p.Q572H|YY1AP1_ENST00000368339.5_Missense_Mutation_p.Q721H|YY1AP1_ENST00000407221.1_Missense_Mutation_p.Q552H|YY1AP1_ENST00000295566.4_Missense_Mutation_p.Q629H	NM_001198904.1	NP_001185833.1			YY1 associated protein 1											central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(7)|ovary(2)|skin(2)|urinary_tract(2)	31	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					TCTGGGGACTCTGGGCCACAG	0.542000													48	44					0	0	0.003610	0	0
HECW2	57520	broad.mit.edu	37	2	197090585	197090585	+	Silent	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr2:197090585G>A	ENST00000260983.3	-	23	4109	c.3927C>T	c.(3925-3927)ttC>ttT	p.F1309F	HECW2_ENST00000409111.1_Silent_p.F953F	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2		HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						TCCTACCACTGAATCGGAACC	0.438000													31	22					0	0	0.001786	0	0
HUWE1	10075	broad.mit.edu	37	X	53631583	53631583	+	Missense_Mutation	SNP	G	G	C	rs141644800		TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chrX:53631583G>C	ENST00000342160.3	-	25	3166	c.2709C>G	c.(2707-2709)atC>atG	p.I903M	HUWE1_ENST00000218328.8_Missense_Mutation_p.I903M|HUWE1_ENST00000262854.6_Missense_Mutation_p.I903M			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	903					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						CAAACATCATGATGTAGGCAT	0.473000													34	0					0	0	0.003271	0	0
RMND5A	64795	broad.mit.edu	37	2	86992169	86992169	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr2:86992169G>A	ENST00000283632.4	+	5	1036	c.541G>A	c.(541-543)Gaa>Aaa	p.E181K		NM_022780.3	NP_073617.1	Q9H871	RMD5A_HUMAN	required for meiotic nuclear division 5 homolog A (S. cerevisiae)	181	CTLH.			E -> G (in Ref. 1; BAB14257).						kidney(1)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	17						GTCAAACCGGGAAATGCTTAT	0.373000													34	40					0	0	0.007835	0	0
STAG2	10735	broad.mit.edu	37	X	123197011	123197011	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chrX:123197011C>T	ENST00000371160.1	+	19	2067	c.1777C>T	c.(1777-1779)Cag>Tag	p.Q593*	STAG2_ENST00000218089.9_Nonsense_Mutation_p.Q593*|STAG2_ENST00000371157.3_Nonsense_Mutation_p.Q593*|STAG2_ENST00000371144.3_Nonsense_Mutation_p.Q593*|STAG2_ENST00000371145.3_Nonsense_Mutation_p.Q593*|STAG2_ENST00000354548.5_Nonsense_Mutation_p.Q524*|STAG2_ENST00000469481.1_Intron	NM_001282418.1	NP_001269347.1	Q8N3U4	STAG2_HUMAN	stromal antigen 2	593					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(9)|lung(21)|ovary(5)|prostate(2)|skin(5)|urinary_tract(4)	78						GCAGTTGCCTCAGTACTTTGA	0.279000													31	1					0	0	0.002445	0	0
MTSS1L	92154	broad.mit.edu	37	16	70713737	70713737	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:70713737C>G	ENST00000338779.6	-	5	608	c.334G>C	c.(334-336)Gag>Cag	p.E112Q		NM_138383.2	NP_612392.1	Q765P7	MTSSL_HUMAN	metastasis suppressor 1-like	112	IMD.				filopodium assembly|signal transduction		actin binding|cytoskeletal adaptor activity|SH3 domain binding			breast(1)|central_nervous_system(2)|endometrium(1)|liver(1)|lung(1)|skin(1)	7						TTCCAGTCCTCGATGCGCTCC	0.726000													14	10					0	0	0.003163	0	0
GAB1	2549	broad.mit.edu	37	4	144361407	144361407	+	Missense_Mutation	SNP	G	G	A	rs66781203		TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr4:144361407G>A	ENST00000262995.4	+	6	1884	c.1457G>A	c.(1456-1458)gGa>gAa	p.G486E	GAB1_ENST00000505913.1_Missense_Mutation_p.G383E|GAB1_ENST00000262994.4_Missense_Mutation_p.G486E	NM_207123.2	NP_997006.1	Q13480	GAB1_HUMAN	GRB2-associated binding protein 1	486	Pro-rich.				cell proliferation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			breast(3)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	30	all_hematologic(180;0.158)					TCCTCATTTGGAATGCAAGTT	0.483000													47	35					0	0	0.003214	0	0
OR4N4	283694	broad.mit.edu	37	15	22382961	22382961	+	Silent	SNP	C	C	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr15:22382961C>T	ENST00000328795.4	+	1	580	c.489C>T	c.(487-489)atC>atT	p.I163I	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	163					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TGGTCCTCATCCTCCGCTTGC	0.522000													55	235					0	0	0.003610	0	0
CDHR1	92211	broad.mit.edu	37	10	85973981	85973981	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr10:85973981G>C	ENST00000372117.3	+	17	2287	c.2184G>C	c.(2182-2184)aaG>aaC	p.K728N	CDHR1_ENST00000440770.2_Missense_Mutation_p.K432N|CDHR1_ENST00000332904.3_Intron	NM_033100.2	NP_149091.1	Q96JP9	CDHR1_HUMAN	cadherin-related family member 1	728					homophilic cell adhesion		calcium ion binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(21)|ovary(1)|prostate(1)|skin(1)	36						GGCGCAACAAGAAGTCTAACA	0.642000													42	35					0	0	0.003610	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140750327	140750327	+	Silent	SNP	G	G	A			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr5:140750327G>A	ENST00000576222.1	+	1	497	c.366G>A	c.(364-366)ctG>ctA	p.L122L	PCDHGB1_ENST00000523390.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAACTGTGCTGATCCAGGATA	0.443000													127	107					0	0	0.003610	0	0
RNF10	9921	broad.mit.edu	37	12	121001667	121001667	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr12:121001667G>T	ENST00000325954.4	+	10	2047	c.1586G>T	c.(1585-1587)cGg>cTg	p.R529L	RNF10_ENST00000413266.2_Missense_Mutation_p.R534L	NM_014868.4	NP_055683.3	Q8N5U6	RNF10_HUMAN	ring finger protein 10	529					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)	27	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TGCCTCGTGCGGGAGTACGGC	0.572000													78	111					5.41795e-27	6.50154e-27	0.003610	1	0
SOX5	6660	broad.mit.edu	37	12	23893927	23893927	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr12:23893927C>G	ENST00000546136.1	-	4	578	c.576G>C	c.(574-576)atG>atC	p.M192I	SOX5_ENST00000541847.1_Missense_Mutation_p.M195I|SOX5_ENST00000537393.1_Missense_Mutation_p.M170I|SOX5_ENST00000545921.1_Missense_Mutation_p.M195I|SOX5_ENST00000309359.1_Missense_Mutation_p.M192I|SOX5_ENST00000381381.2_Missense_Mutation_p.M192I|SOX5_ENST00000541536.1_Missense_Mutation_p.M192I|SOX5_ENST00000451604.2_Missense_Mutation_p.M205I			P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5	205					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(25)|ovary(5)|skin(2)|upper_aerodigestive_tract(3)	57						GCTGGTTGATCATACCCATGA	0.438000													31	36					0	0	0.001786	0	0
PMS2P4	5382	broad.mit.edu	37	7	66764305	66764305	+	RNA	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr7:66764305C>G	ENST00000414507.1	-	0	150																											AGACTGTTTTCTACTAACTCC	0.453000													5	387					0	0	0.001168	0	0
ABCD3	5825	broad.mit.edu	37	1	94964399	94964399	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:94964399C>G	ENST00000370214.4	+	18	1549	c.1525C>G	c.(1525-1527)Cct>Gct	p.P509A	ABCD3_ENST00000394233.2_Missense_Mutation_p.P399A|ABCD3_ENST00000454898.2_Missense_Mutation_p.P533A|ABCD3_ENST00000536817.1_Missense_Mutation_p.P436A|ABCD3_ENST00000484213.1_3'UTR	NM_002858.3	NP_002849.1	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D (ALD), member 3	509	ABC transporter.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(2)|lung(10)|ovary(1)|pancreas(1)|skin(2)	26		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		ATTTTATGTTCCTCAGGTAAG	0.318000													38	42					0	0	0.006230	0	0
UNC5B	219699	broad.mit.edu	37	10	73053303	73053303	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr10:73053303G>C	ENST00000335350.6	+	12	2330	c.1914G>C	c.(1912-1914)aaG>aaC	p.K638N	UNC5B_ENST00000373192.4_Missense_Mutation_p.K627N	NM_170744.4	NP_734465.2	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B (C. elegans)	638	ZU5.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(4)|skin(4)	49						TTCAGCTCAAGACCCAGGCCC	0.637000													32	48					0	0	0.003271	0	0
IGSF10	285313	broad.mit.edu	37	3	151166216	151166216	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr3:151166216C>G	ENST00000282466.3	-	4	1552	c.1553G>C	c.(1552-1554)aGa>aCa	p.R518T		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	518	Ig-like C2-type 1.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ATAAGGGGCTCTCACTTTACT	0.498000													103	108					0	0	0.003610	0	0
DNAJC11	55735	broad.mit.edu	37	1	6694732	6694732	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:6694732delC	ENST00000349363.6	-	8	852	c.811delG	c.(811-813)gaafs	p.E271fs	DNAJC11_ENST00000465508.1_5'UTR|THAP3_ENST00000377627.3_3'UTR|DNAJC11_ENST00000377577.5_3'UTR			Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	0					protein folding		heat shock protein binding|unfolded protein binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(11)|lung(8)|ovary(2)|skin(1)|urinary_tract(1)	32	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		CCGCTGCATTCTGCATCCCAA	0.637											OREG0013046	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	8	---	---	---	---					
RP11-435B5.5	0	broad.mit.edu	37	1	143391923	143391924	+	RNA	DEL	AT	AT	-			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr1:143391923_143391924delAT	ENST00000428624.1	+	0	2065				RP11-435B5.4_ENST00000423249.1_lincRNA																							TATTTTGGAGATATATATATAT	0.262													3	3	---	---	---	---					
CDKN1A	1026	broad.mit.edu	37	6	36651923	36651930	+	Frame_Shift_Del	DEL	CAAGGCCT	CAAGGCCT	-			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr6:36651923_36651930delCAAGGCCT	ENST00000405375.1	+	2	280_287	c.45_52delCAAGGCCT	c.(43-54)agcaaggcctgcfs	p.SKAC15fs	CDKN1A_ENST00000244741.5_Frame_Shift_Del_p.SKAC15fs|CDKN1A_ENST00000478800.1_3'UTR|CDKN1A_ENST00000448526.2_Frame_Shift_Del_p.SKAC49fs|CDKN1A_ENST00000373711.2_Frame_Shift_Del_p.SKAC15fs	NM_001220778.1	NP_001207707.1	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	15					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding	p.S15fs*15(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|urinary_tract(5)	15						CATGCGGCAGCAAGGCCTGCCGCCGCCT	0.635													11	1	---	---	---	---					
STAG3L4	64940	broad.mit.edu	37	7	66772494	66772495	+	RNA	INS	-	-	T	rs113583073		TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr7:66772494_66772495insT	ENST00000416602.2	+	0	362					NR_040586.1		Q8TBR4	STG34_HUMAN												endometrium(2)|lung(5)	7		Lung NSC(55;0.0839)|all_lung(88;0.181)				TGCTTGATTCCTTTTTTTTTTT	0.426													4	6	---	---	---	---					
AZGP1P1	646282	broad.mit.edu	37	7	99581179	99581179	+	RNA	DEL	C	C	-			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr7:99581179delC	ENST00000425474.1	+	0	500					NR_036679.1																						CCGCATCCCACCCCCCCCACA	0.577													2	4	---	---	---	---					
RP11-273B20.3	0	broad.mit.edu	37	12	7338794	7338794	+	RNA	DEL	G	G	-	rs34548221		TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr12:7338794delG	ENST00000545794.1	-	0	279				RP11-273B20.3_ENST00000543061.1_RNA																							cctgttgagaggggggactga	0.502													3	4	---	---	---	---					
SYCP3	50511	broad.mit.edu	37	12	102122901	102122901	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr12:102122901delT	ENST00000392927.3	-	8	774	c.643delA	c.(643-645)attfs	p.I215fs	SYCP3_ENST00000266743.2_Frame_Shift_Del_p.I215fs|SYCP3_ENST00000392924.1_Frame_Shift_Del_p.I215fs	NM_001177948.1|NM_001177949.1|NM_153694.4	NP_001171419.1|NP_001171420.1|NP_710161.1	Q8IZU3	SYCP3_HUMAN	synaptonemal complex protein 3	215	Gln-rich.				cell division|male meiosis I|spermatogenesis, exchange of chromosomal proteins	nucleus	DNA binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(5)|skin(1)	11						TCCATCATAATTTTTTTTTGC	0.259													7	70	---	---	---	---					
NCOR2	9612	broad.mit.edu	37	12	124885065	124885065	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr12:124885065delG	ENST00000356219.3	-	16	1950	c.1795delC	c.(1795-1797)cagfs	p.Q600fs	NCOR2_ENST00000397355.1_Frame_Shift_Del_p.Q600fs|NCOR2_ENST00000404621.1_Frame_Shift_Del_p.Q599fs|NCOR2_ENST00000405201.1_Frame_Shift_Del_p.Q600fs|NCOR2_ENST00000404121.2_Frame_Shift_Del_p.Q170fs|NCOR2_ENST00000429285.2_Frame_Shift_Del_p.Q599fs	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	600					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GCGCTCTGCTGGGGGGTGATG	0.622													65	92	---	---	---	---					
ITFG1	81533	broad.mit.edu	37	16	47195718	47195719	+	Frame_Shift_Ins	INS	-	-	CAGTC			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:47195718_47195719insCAGTC	ENST00000320640.6	-	16	1831_1832	c.1603_1604insGACTG	c.(1603-1605)gcafs	p.A535fs	RP11-329J18.2_ENST00000564705.1_RNA|RP11-329J18.2_ENST00000565694.1_RNA|ITFG1_ENST00000568047.1_5'UTR|ITFG1_ENST00000544001.2_Frame_Shift_Ins_p.A422fs	NM_030790.3	NP_110417.2	Q8TB96	TIP_HUMAN	integrin alpha FG-GAP repeat containing 1	535						extracellular region|integral to membrane				breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	19		all_cancers(37;0.0613)|all_lung(18;0.0543)|Lung NSC(13;0.227)				TGGAATGATTGCAGTCCACTCT	0.337													7	109	---	---	---	---					
PDXDC2P	283970	broad.mit.edu	37	16	70066043	70066043	+	RNA	DEL	A	A	-			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:70066043delA	ENST00000531894.1	-	0	751					NR_003610.1																						AGCCAAGCCGAAAAAAAAAAA	0.289													4	6	---	---	---	---					
RP11-252A24.2	0	broad.mit.edu	37	16	74372915	74372915	+	RNA	DEL	T	T	-	rs67181940		TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr16:74372915delT	ENST00000429810.2	-	0	1404																											ACGTAGtttgttttttttttt	0.438													5	8	---	---	---	---					
MEX3D	399664	broad.mit.edu	37	19	1556090	1556090	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:1556090delA	ENST00000402693.4	-	2	1427	c.1428delT	c.(1426-1428)tttfs	p.F476fs	MEX3D_ENST00000388824.6_Frame_Shift_Del_p.F476fs	NM_203304.3	NP_976049.3	Q86XN8	MEX3D_HUMAN	mex-3 RNA binding family member D	476					mRNA destabilization|posttranscriptional regulation of gene expression by mRNA localization|regulation of anti-apoptosis	nucleus|perinuclear region of cytoplasm	AU-rich element binding|zinc ion binding			endometrium(1)|lung(3)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGCGCGCTCAAAAGGCGCCC	0.756													2	4	---	---	---	---					
RASIP1	54922	broad.mit.edu	37	19	49232663	49232663	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr19:49232663delC	ENST00000222145.4	-	5	1568	c.1364delG	c.(1363-1365)ggcfs	p.G455fs		NM_017805.2	NP_060275.2	Q5U651	RAIN_HUMAN	Ras interacting protein 1	455					signal transduction	Golgi stack|perinuclear region of cytoplasm				central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	21		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		GACTGGGGCGCCCCGGGACGG	0.701													2	4	---	---	---	---					
RP13-329D4.3	0	broad.mit.edu	37	20	26113543	26113543	+	RNA	DEL	A	A	-			TCGA-CF-A27C-01A-11D-A16O-08	TCGA-CF-A27C-10A-01D-A16O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	acc629cb-ad03-4cec-9b21-922e4932ef3e	7c729b94-1488-4dec-b534-5d73530e535c	g.chr20:26113543delA	ENST00000416563.1	-	0	250																											TCTTTGCCTTAACAACATTAT	0.363													2	4	---	---	---	---					
