Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KLHDC4	54758	broad.mit.edu	37	16	87743024	87743024	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr16:87743024G>A	ENST00000270583.5	-	10	1352	c.1294C>T	c.(1294-1296)Cgc>Tgc	p.R432C	KLHDC4_ENST00000566349.1_5'UTR|KLHDC4_ENST00000347925.5_Missense_Mutation_p.R401C|KLHDC4_ENST00000353170.5_Missense_Mutation_p.R375C	NM_017566.3	NP_060036.2	Q8TBB5	KLDC4_HUMAN	kelch domain containing 4	432										breast(2)|endometrium(3)|lung(10)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(2)	21				BRCA - Breast invasive adenocarcinoma(80;0.0283)		GCGTTGGAGCGTGGACACGGC	0.682000													42	137					0	0	1	0	0
KIF25	3834	broad.mit.edu	37	6	168430266	168430266	+	Translation_Start_Site	SNP	A	A	C			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr6:168430266A>C	ENST00000443060.2	+	3	392	c.1A>C	c.(1-3)Atg>Ctg	p.M1L	KIF25_ENST00000351261.3_Start_Codon_SNP_p.M1L|KIF25_ENST00000354419.2_Start_Codon_SNP_p.M1L			Q9UIL4	KIF25_HUMAN	kinesin family member 25	1	Kinesin-motor.				microtubule-based movement|mitotic sister chromatid segregation	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity	p.M1L(1)		NS(2)|breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		GCCTTCCCAGATGACATGGAC	0.602000													3	188					0	0	1	0	0
SLC5A1	6523	broad.mit.edu	37	22	32498214	32498214	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr22:32498214C>T	ENST00000266088.4	+	13	1905	c.1655C>T	c.(1654-1656)cCg>cTg	p.P552L	SLC5A1_ENST00000543737.1_Missense_Mutation_p.P425L	NM_000343.3	NP_000334.1	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 1	552					carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(2)|skin(4)|urinary_tract(1)	37						AAACCCATTCCGGATGTGCAT	0.403000													15	165					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38942452	38942452	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr19:38942452C>T	ENST00000355481.4	+	12	1302	c.1171C>T	c.(1171-1173)Cgc>Tgc	p.R391C	RYR1_ENST00000360985.3_Missense_Mutation_p.R391C|RYR1_ENST00000359596.3_Missense_Mutation_p.R391C	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	391	MIR 5.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GTCGCTGACCCGCTGCCAGCA	0.647000													4	184					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23527693	23527693	+	Silent	SNP	T	T	C			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr5:23527693T>C	ENST00000296682.3	+	11	2678	c.2496T>C	c.(2494-2496)taT>taC	p.Y832Y		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	832					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding	p.Y832Y(1)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						AGAAGCCCTATGTCTGCAGGG	0.587000										HNSCC(3;0.000094)			4	242					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.3_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													3	58					0	0	1	0	0
DCAF12	25853	broad.mit.edu	37	9	34107398	34107398	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr9:34107398T>C	ENST00000361264.4	-	3	840	c.499A>G	c.(499-501)Atc>Gtc	p.I167V	DCAF12_ENST00000463286.1_5'UTR	NM_015397.3	NP_056212.1	Q5T6F0	DCA12_HUMAN	DDB1 and CUL4 associated factor 12	167						centrosome|CUL4 RING ubiquitin ligase complex				breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)	11						AGTCGATAGATGGCAAGACTG	0.507000													48	55					0	0	1	0	0
OPRL1	4987	broad.mit.edu	37	20	62730140	62730140	+	Silent	SNP	G	G	A	rs138878509		TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr20:62730140G>A	ENST00000349451.3	+	6	1513	c.1101G>A	c.(1099-1101)ccG>ccA	p.P367P	OPRL1_ENST00000355631.4_Silent_p.P367P|OPRL1_ENST00000336866.2_Silent_p.P367P	NM_001200019.1	NP_001186948.1	P41146	OPRX_HUMAN	opiate receptor-like 1	367					elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					AGACGGTACCGCGGCCCGCAT	0.657000													15	76					0	0	1	0	0
TMEM132D	121256	broad.mit.edu	37	12	129822249	129822249	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr12:129822249G>A	ENST00000422113.2	-	4	1555	c.1229C>T	c.(1228-1230)aCg>aTg	p.T410M		NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	410						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CAAGTCAGACGTGATCTCTCC	0.572000													9	502					0	0	1	0	0
KDM6B	23135	broad.mit.edu	37	17	7751016	7751016	+	Silent	SNP	A	A	C			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr17:7751016A>C	ENST00000254846.5	+	11	1799	c.1410A>C	c.(1408-1410)ccA>ccC	p.P470P	KDM6B_ENST00000448097.2_Silent_p.P470P	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	470	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						caccccctccacccccctgtc	0.687000													6	11					0	0	1	0	0
MDGA1	266727	broad.mit.edu	37	6	37605212	37605212	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr6:37605212C>T	ENST00000297153.7	-	18	3990	c.2812G>A	c.(2812-2814)Gcc>Acc	p.A938T	MDGA1_ENST00000434837.3_Missense_Mutation_p.A934T			Q8NFP4	MDGA1_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 1	934					brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	38						TGGCAGGGGGCTCCACTGCCC	0.652000													27	65					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61525841	61525841	+	Silent	SNP	G	G	A			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr20:61525841G>A	ENST00000266070.4	-	11	2821	c.2496C>T	c.(2494-2496)gtC>gtT	p.V832V	DIDO1_ENST00000395335.2_Silent_p.V832V|DIDO1_ENST00000395340.1_Silent_p.V832V|DIDO1_ENST00000395343.1_Silent_p.V832V	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	832					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					TGCTGCTGAAGACGTCGAGAA	0.498000													18	69					0	0	1	0	0
KRI1	65095	broad.mit.edu	37	19	10664773	10664773	+	Missense_Mutation	SNP	G	G	A	rs147727983		TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr19:10664773G>A	ENST00000312962.6	-	19	2003	c.1984C>T	c.(1984-1986)Cgg>Tgg	p.R662W	KRI1_ENST00000361821.5_Missense_Mutation_p.R658W	NM_023008.3	NP_075384.3	Q8N9T8	KRI1_HUMAN	KRI1 homolog (S. cerevisiae)	662										NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	26			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			CCCAGCAGCCGTGCCTTCTTG	0.642000													49	183					0	0	1	0	0
CDCA7	83879	broad.mit.edu	37	2	174223511	174223511	+	Silent	SNP	G	G	A	rs142079460		TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr2:174223511G>A	ENST00000306721.3	+	2	196	c.93G>A	c.(91-93)tcG>tcA	p.S31S	CDCA7_ENST00000410101.3_Silent_p.S31S|CDCA7_ENST00000410019.3_Intron|CDCA7_ENST00000392567.2_Silent_p.S31S|CDCA7_ENST00000347703.3_Silent_p.S31S	NM_031942.4	NP_114148.3	Q9BWT1	CDCA7_HUMAN	cell division cycle associated 7	0					regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)	18			OV - Ovarian serous cystadenocarcinoma(117;0.116)			TGGAAACCTCGTCATCCTCTG	0.383000													16	24					0	0	1	0	0
DNAJB6	10049	broad.mit.edu	37	7	157178324	157178324	+	Missense_Mutation	SNP	G	G	A	rs148391683	by1000genomes	TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr7:157178324G>A	ENST00000429029.2	+	8	915	c.710G>A	c.(709-711)cGc>cAc	p.R237H	DNAJB6_ENST00000443280.1_Intron|DNAJB6_ENST00000262177.4_Intron|DNAJB6_ENST00000452797.2_Intron	NM_005494.2	NP_005485.1	O75190	DNJB6_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 6	0	Interaction with KRT18.				intermediate filament organization|negative regulation of caspase activity|protein folding|response to unfolded protein	nucleus|perinuclear region of cytoplasm	ATPase activator activity|chaperone binding|heat shock protein binding|unfolded protein binding			central_nervous_system(1)|lung(1)|ovary(2)|stomach(1)	5	all_neural(206;0.181)	all_epithelial(9;0.000606)|all_hematologic(28;0.00287)|Acute lymphoblastic leukemia(9;0.0647)|Ovarian(593;0.196)	OV - Ovarian serous cystadenocarcinoma(82;0.00399)	UCEC - Uterine corpus endometrioid carcinoma (81;0.172)		CAGCTGCTGCGCTTGGATAAC	0.368000													9	59					0	0	1	0	0
WASH2P	375260	broad.mit.edu	37	2	114355129	114355129	+	RNA	SNP	G	G	A			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr2:114355129G>A	ENST00000538033.2	+	0	2068																											GAGTCCATCCGCCAAGCTGGG	0.657000													5	19					0	0	1	0	0
PNLIP	5406	broad.mit.edu	37	10	118314751	118314751	+	Silent	SNP	C	C	T			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr10:118314751C>T	ENST00000369221.2	+	7	661	c.633C>T	c.(631-633)agC>agT	p.S211S		NM_000936.2	NP_000927.1	P16233	LIPP_HUMAN	pancreatic lipase	211					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	43				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	TGGACCCCAGCGATGCCAAAT	0.483000													14	56					0	0	1	0	0
PGAM5	192111	broad.mit.edu	37	12	133294647	133294647	+	Silent	SNP	G	G	A			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr12:133294647G>A	ENST00000498926.2	+	5	718	c.660G>A	c.(658-660)gaG>gaA	p.E220E	PGAM5_ENST00000543955.1_Silent_p.E71E|PGAM5_ENST00000317555.2_Silent_p.E220E|PGAM5_ENST00000454808.2_Silent_p.E71E|PXMP2_ENST00000545677.1_3'UTR|PGAM5_ENST00000541034.1_3'UTR	NM_001170543.1|NM_001170544.1	NP_001164014.1|NP_001164015.1	Q96HS1	PGAM5_HUMAN	phosphoglycerate mutase family member 5	220						integral to membrane|mitochondrial outer membrane	phosphoprotein phosphatase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)	5	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.89e-08)|Epithelial(86;1.14e-07)|all cancers(50;3.57e-06)		CCAGGCAGGAGGAGGACAGTT	0.582000													5	293					0	0	1	0	0
XG	7499	broad.mit.edu	37	X	2729397	2729397	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chrX:2729397G>A	ENST00000426774.1	+	9	656	c.433G>A	c.(433-435)Gtg>Atg	p.V145M	XG_ENST00000419513.2_Missense_Mutation_p.V159M|XG_ENST00000381174.5_Missense_Mutation_p.V144M	NM_001141920.1|NM_175569.2	NP_001135392.1|NP_780778.1	P55808	XG_HUMAN	Xg blood group	144						integral to membrane|plasma membrane		p.V144M(1)		endometrium(1)|large_intestine(3)|lung(3)|ovary(1)	8		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				AGCAAAAATCGTGTCTCCCAT	0.448000													18	18					0	0	1	0	0
ATP1A2	477	broad.mit.edu	37	1	160098456	160098456	+	Silent	SNP	G	G	C			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr1:160098456G>C	ENST00000361216.3	+	9	1121	c.1032G>C	c.(1030-1032)ctG>ctC	p.L344L	ATP1A2_ENST00000392233.3_Silent_p.L344L	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	344					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			GCCTGACCCTGACAGCCAAGC	0.572000													3	104					0	0	1	0	0
DEFB131	644414	broad.mit.edu	37	4	9452168	9452168	+	Silent	SNP	T	T	C			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr4:9452168T>C	ENST00000334879.1	+	2	141	c.141T>C	c.(139-141)atT>atC	p.I47I		NM_001040448.2|NM_001242853.1	NP_001035538.2|NP_001229782.1	P59861	DB131_HUMAN	defensin, beta 131	47					defense response to bacterium	extracellular region				lung(2)	2						AACATGCAATTAGATACTGTG	0.373000													4	24					0	0	1	0	0
RNF169	254225	broad.mit.edu	37	11	74547713	74547713	+	Silent	SNP	C	C	A			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr11:74547713C>A	ENST00000299563.4	+	6	2078	c.2065C>A	c.(2065-2067)Cgg>Agg	p.R689R		NM_001098638.1	NP_001092108.1	Q8NCN4	RN169_HUMAN	ring finger protein 169	689							zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|urinary_tract(1)	15						GACTGTGAGCCGGCGAAAAGG	0.517000													4	94					0.014758	0.0153367	1	1	0
NBPF8	728841	broad.mit.edu	37	1	144220816	144220816	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr1:144220816A>G	ENST00000369373.5	+	2	83	c.83A>G	c.(82-84)gAg>gGg	p.E28G						neuroblastoma breakpoint family, member 8																		GATGAGAAAGAGCCTGAAGTC	0.483000													5	254					0	0	1	0	0
CDKN1A	1026	broad.mit.edu	37	6	36652024	36652024	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr6:36652024G>A	ENST00000405375.1	+	2	381	c.146G>A	c.(145-147)tGg>tAg	p.W49*	CDKN1A_ENST00000478800.1_3'UTR|CDKN1A_ENST00000244741.5_Nonsense_Mutation_p.W49*|CDKN1A_ENST00000373711.2_Nonsense_Mutation_p.W49*|CDKN1A_ENST00000448526.2_Nonsense_Mutation_p.W83*	NM_001220778.1	NP_001207707.1	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	49					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding	p.W49*(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|urinary_tract(5)	15						CGTGAGCGATGGAACTTCGAC	0.667000													82	12					0	0	1	0	0
TMEM104	54868	broad.mit.edu	37	17	72832099	72832099	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr17:72832099G>A	ENST00000335464.5	+	10	926	c.764G>A	c.(763-765)cGc>cAc	p.R255H	TMEM104_ENST00000582773.1_Intron|TMEM104_ENST00000417024.2_Intron|TMEM104_ENST00000582330.1_Missense_Mutation_p.R255H	NM_017728.3	NP_060198.3	Q8NE00	TM104_HUMAN	transmembrane protein 104	255						integral to membrane				NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(5)|ovary(1)	19	all_lung(278;0.23)					GCCCTGATCCGCATCGGGCAC	0.627000													5	272					0	0	1	0	0
TLN1	7094	broad.mit.edu	37	9	35706250	35706250	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr9:35706250C>G	ENST00000314888.9	-	40	5657	c.5304G>C	c.(5302-5304)ttG>ttC	p.L1768F	TLN1_ENST00000540444.1_Missense_Mutation_p.L1752F|TLN1_ENST00000464379.1_Intron	NM_006289.3	NP_006280.3	Q9Y490	TLN1_HUMAN	talin 1	1768	Interaction with SYNM.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			NS(2)|breast(8)|central_nervous_system(2)|endometrium(10)|kidney(5)|large_intestine(9)|lung(32)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(6)	85	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CAGACTCTGCCAATGTTTTAG	0.582000													5	196					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151962205	151962205	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr7:151962205C>G	ENST00000355193.2	-	8	1320	c.1102G>C	c.(1102-1104)Gga>Cga	p.G368R	KMT2C_ENST00000262189.6_Missense_Mutation_p.G368R					lysine (K)-specific methyltransferase 2C																		AGGCACATTCCATGATAGTGC	0.443000													25	636					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90162555	90162555	+	RNA	SNP	C	C	T			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr16:90162555C>T	ENST00000564451.1	+	0	1908				TUBB8P7_ENST00000567960.1_RNA																							ATGCCACGGCCGAGGAGGAGG	0.522000													4	144					0	0	1	0	0
ANKRD2	26287	broad.mit.edu	37	10	99338106	99338106	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr10:99338106G>A	ENST00000307518.5	+	3	647	c.380G>A	c.(379-381)cGg>cAg	p.R127Q	ANKRD2_ENST00000370655.1_Missense_Mutation_p.R100Q|ANKRD2_ENST00000298808.5_Missense_Mutation_p.R127Q|ANKRD2_ENST00000455090.1_Missense_Mutation_p.R100Q			Q9GZV1	ANKR2_HUMAN	ankyrin repeat domain 2 (stretch responsive muscle)	127					muscle contraction|muscle organ development		structural constituent of muscle			breast(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|stomach(1)	7		all_hematologic(284;1.95e-06)|Colorectal(252;0.0163)		Epithelial(162;1.18e-94)|all cancers(201;9.31e-86)|BRCA - Breast invasive adenocarcinoma(275;0.0233)|STAD - Stomach adenocarcinoma(243;0.181)|KIRC - Kidney renal clear cell carcinoma(50;0.206)|Kidney(138;0.241)		CAGAAGAAGCGGGACGCTCTG	0.687000													9	60					0	0	1	0	0
NBPF14	25832	broad.mit.edu	37	1	148015635	148015635	+	Silent	SNP	A	A	C			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr1:148015635A>C	ENST00000369219.1	-	8	1012	c.996T>G	c.(994-996)gtT>gtG	p.V332V				Q5TI25	NBPFE_HUMAN	neuroblastoma breakpoint family, member 14	332	NBPF 3.					cytoplasm				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(23)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	42	all_hematologic(923;0.032)					CATCCATGTTAACAGCCAAGC	0.468000													2	3					0	0	1	0	0
AXIN2	8313	broad.mit.edu	37	17	63532493	63532493	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr17:63532493G>A	ENST00000307078.5	-	8	2399	c.2086C>T	c.(2086-2088)Cag>Tag	p.Q696*	AXIN2_ENST00000375702.5_Nonsense_Mutation_p.Q631*	NM_004655.3	NP_004646.3	Q9Y2T1	AXIN2_HUMAN	axin 2	696				Q -> H (in Ref. 2; AAF22799).	cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	34						TCCTCCAGCTGAGCCAGCGTG	0.667000									Oligodontia, Ectodermal Dysplasia and Colorectal Polyp syndrome				5	73					0	0	1	0	0
GATAD2A	54815	broad.mit.edu	37	19	19606680	19606680	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr19:19606680G>A	ENST00000404158.1	+	8	1160	c.742G>A	c.(742-744)Gtc>Atc	p.V248I	GATAD2A_ENST00000537887.1_Intron|GATAD2A_ENST00000360315.3_Missense_Mutation_p.V248I|GATAD2A_ENST00000358713.3_Missense_Mutation_p.V248I|GATAD2A_ENST00000252577.5_Missense_Mutation_p.V248I|GATAD2A_ENST00000429563.2_Missense_Mutation_p.V75I			Q86YP4	P66A_HUMAN	GATA zinc finger domain containing 2A	248					DNA methylation|negative regulation of transcription, DNA-dependent	nuclear speck|NuRD complex	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	13						GCCCCCACTCGTCAGGGGGGC	0.672000													17	56					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13338283	13338283	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr19:13338283C>T	ENST00000360228.5	-	37	5586	c.5587G>A	c.(5587-5589)Ggt>Agt	p.G1863S	CACNA1A_ENST00000573710.2_Intron	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1864					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TTCCCCAGACCCAGGGGCGGA	0.502000													25	143					0	0	1	0	0
ZNF568	374900	broad.mit.edu	37	19	37441625	37441625	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr19:37441625C>A	ENST00000415168.1	+	5	1754	c.1378C>A	c.(1378-1380)Cat>Aat	p.H460N	ZNF568_ENST00000427117.1_Intron|ZNF568_ENST00000333987.7_Missense_Mutation_p.H524N|ZNF568_ENST00000455427.2_Intron	NM_001204837.1	NP_001191766.1	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	524					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(9)|ovary(1)	29	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGAGAAAATTCATACTGGAGA	0.383000													3	49					0.014758	0.0153367	1	1	0
SMTN	6525	broad.mit.edu	37	22	31500334	31500334	+	Missense_Mutation	SNP	T	T	A			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr22:31500334T>A	ENST00000358743.1	+	21	2923	c.2705T>A	c.(2704-2706)gTg>gAg	p.V902E	SMTN_ENST00000404574.1_3'UTR|SMTN_ENST00000333137.7_3'UTR|SMTN_ENST00000347557.2_Missense_Mutation_p.V879E	NM_134270.2	NP_599032.2	P53814	SMTN_HUMAN	smoothelin	879	CH.				muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			breast(2)|endometrium(2)|large_intestine(5)|lung(9)|ovary(3)|pancreas(1)|prostate(3)	25						CTGGTGGAGGTGGACGACATG	0.632000													40	170					0	0	1	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2341289	2341289	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr4:2341289C>A	ENST00000290974.2	-	4	751	c.412G>T	c.(412-414)Gtg>Ttg	p.V138L	ZFYVE28_ENST00000515312.1_Missense_Mutation_p.V68L|ZFYVE28_ENST00000511071.1_Missense_Mutation_p.V138L|ZFYVE28_ENST00000515169.1_Missense_Mutation_p.V68L|ZFYVE28_ENST00000503000.1_Missense_Mutation_p.V138L|ZFYVE28_ENST00000509171.1_Missense_Mutation_p.V91L	NM_020972.2	NP_066023.2	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	138					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	31						GCGCCCCGCACGTCCTCCAGG	0.667000													21	9					1.55795e-14	1.75683e-14	1	1	0
RFX4	5992	broad.mit.edu	37	12	107155161	107155161	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr12:107155161C>T	ENST00000392842.1	+	18	2536	c.2122C>T	c.(2122-2124)Cgc>Tgc	p.R708C	RP11-144F15.1_ENST00000551505.1_Intron|RFX4_ENST00000357881.4_Missense_Mutation_p.R717C|RFX4_ENST00000229387.5_Missense_Mutation_p.R614C	NM_213594.2	NP_998759.1	Q33E94	RFX4_HUMAN	regulatory factor X, 4 (influences HLA class II expression)	708					transcription, DNA-dependent	nucleus	DNA binding			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(20)|pancreas(1)|upper_aerodigestive_tract(1)	35						TCTGACAACGCGCAGGAATTC	0.512000													16	81					0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23544783	23544783	+	Missense_Mutation	SNP	C	C	T	rs410211		TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr19:23544783C>T	ENST00000300619.7	-	4	1203	c.998G>A	c.(997-999)cGt>cAt	p.R333H	ZNF91_ENST00000599743.1_Intron|ZNF91_ENST00000397082.2_Missense_Mutation_p.R301H	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	333				R -> H (in Ref. 1; AAA59469).		nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R333H(1)					all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				GGTTGAAGAACGGCTAAAAGC	0.393000													5	113					0	0	1	0	0
ZNF10	7556	broad.mit.edu	37	12	133732511	133732511	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr12:133732511C>T	ENST00000248211.6	+	5	901	c.679C>T	c.(679-681)Cag>Tag	p.Q227*	ZNF268_ENST00000416488.1_Intron|CTD-2140B24.4_ENST00000540096.2_Intron|ZNF10_ENST00000402932.2_Intron|ZNF10_ENST00000426665.2_Nonsense_Mutation_p.Q227*	NM_015394.4	NP_056209.2	P21506	ZNF10_HUMAN	zinc finger protein 10	227			Q -> R (in dbSNP:rs11147259).	Missing (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|prostate(1)|skin(5)|urinary_tract(1)	26	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		TCACCTTATTCAGTTTGCAAG	0.358000													13	73					0	0	1	0	0
SEMA5B	54437	broad.mit.edu	37	3	122642517	122642517	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr3:122642517C>T	ENST00000195173.4	-	10	1522	c.1219G>A	c.(1219-1221)Gag>Aag	p.E407K	SEMA5B_ENST00000451055.2_Missense_Mutation_p.E461K|SEMA5B_ENST00000357599.3_Missense_Mutation_p.E407K			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	407	Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		CTGGGGTTCTCCTGGTAGCGA	0.557000													57	146					0	0	1	0	0
ZNF563	147837	broad.mit.edu	37	19	12429722	12429722	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr19:12429722T>C	ENST00000293725.5	-	4	1322	c.1117A>G	c.(1117-1119)Acg>Gcg	p.T373A		NM_145276.2	NP_660319.1	Q8TA94	ZN563_HUMAN	zinc finger protein 563	373					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						TGAGATAACGTTTTCCCACAC	0.413000													4	194					0	0	1	0	0
ZMYND8	23613	broad.mit.edu	37	20	45853033	45853033	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr20:45853033A>G	ENST00000311275.7	-	19	3386	c.3133T>C	c.(3133-3135)Tac>Cac	p.Y1045H	ZMYND8_ENST00000352431.2_Missense_Mutation_p.Y1019H|ZMYND8_ENST00000446994.2_Missense_Mutation_p.Y936H|ZMYND8_ENST00000458360.2_Missense_Mutation_p.Y913H|ZMYND8_ENST00000536340.1_Missense_Mutation_p.Y1072H|ZMYND8_ENST00000461685.1_Missense_Mutation_p.Y1019H|ZMYND8_ENST00000540497.1_Missense_Mutation_p.Y993H|ZMYND8_ENST00000355972.4_Missense_Mutation_p.Y1045H|ZMYND8_ENST00000396281.4_Missense_Mutation_p.Y1045H|ZMYND8_ENST00000360911.3_Missense_Mutation_p.Y994H|ZMYND8_ENST00000262975.4_Missense_Mutation_p.Y999H|ZMYND8_ENST00000471951.2_Missense_Mutation_p.Y1065H|ZMYND8_ENST00000372023.3_Missense_Mutation_p.Y967H	NM_001281772.1|NM_001281778.1|NM_001281783.1	NP_001268701.1|NP_001268707.1|NP_001268712.1	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8	1045							protein binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|prostate(3)|skin(2)|urinary_tract(8)	62			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			TAGTCACAGTAGCTAGTGTTC	0.587000													50	202					0	0	1	0	0
HSD11B2	3291	broad.mit.edu	37	16	67470804	67470804	+	Silent	SNP	G	G	A			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr16:67470804G>A	ENST00000326152.5	+	5	1248	c.1116G>A	c.(1114-1116)ctG>ctA	p.L372L		NM_000196.3	NP_000187.3	P80365	DHI2_HUMAN	hydroxysteroid (11-beta) dehydrogenase 2	372					glucocorticoid biosynthetic process	endoplasmic reticulum|microsome				breast(1)|endometrium(1)|liver(2)|lung(3)|upper_aerodigestive_tract(1)	8		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0401)|Epithelial(162;0.0891)	NADH(DB00157)	GTCACTGTCTGCCTCGAGCAC	0.662000													49	134					0	0	1	0	0
C11orf82	220042	broad.mit.edu	37	11	82644614	82644614	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr11:82644614C>A	ENST00000533655.1	+	6	2446	c.2234C>A	c.(2233-2235)tCa>tAa	p.S745*	C11orf82_ENST00000528759.1_3'UTR|C11orf82_ENST00000329143.3_Nonsense_Mutation_p.S444*|C11orf82_ENST00000430323.2_Nonsense_Mutation_p.S745*|C11orf82_ENST00000525361.1_Intron	NM_145018.3	NP_659455.3	Q8IXT1	NOXIN_HUMAN	chromosome 11 open reading frame 82	745					apoptosis|cell cycle arrest	cytoplasm|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	33						TCTAGGCATTCAAGAACATGC	0.373000													3	37					1	1	1	1	0
PTGFR	5737	broad.mit.edu	37	1	78958508	78958508	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr1:78958508G>A	ENST00000370756.3	+	2	317	c.80G>A	c.(79-81)cGg>cAg	p.R27Q	PTGFR_ENST00000370758.1_Missense_Mutation_p.R27Q|PTGFR_ENST00000370757.3_Missense_Mutation_p.R27Q	NM_001039585.1	NP_001034674.1	P43088	PF2R_HUMAN	prostaglandin F receptor (FP)	27					parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			breast(6)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	33				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	ACGGAAAACCGGCTTTCCGTA	0.438000													5	54					0	0	1	0	0
UPF3A	65110	broad.mit.edu	37	13	115047559	115047559	+	Silent	SNP	C	C	T			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr13:115047559C>T	ENST00000375299.3	+	2	327	c.271C>T	c.(271-273)Ctg>Ttg	p.L91L	UPF3A_ENST00000351487.5_Silent_p.L91L	NM_023011.3	NP_075387.1	Q9H1J1	REN3A_HUMAN	UPF3 regulator of nonsense transcripts homolog A (yeast)	91	Required for interaction with UPF2.				mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation	cytoplasm|nucleus|plasma membrane	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding	p.L91L(8)		autonomic_ganglia(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	16	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)	OV - Ovarian serous cystadenocarcinoma(48;0.195)|Epithelial(10;0.2)		GCTGCGCCCGCTGCCAGCACA	0.731000													4	16					0	0	1	0	0
ATG16L2	89849	broad.mit.edu	37	11	72536397	72536397	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr11:72536397C>A	ENST00000321297.5	+	10	1185	c.1047C>A	c.(1045-1047)agC>agA	p.S349R	ATG16L2_ENST00000534905.1_Intron	NM_033388.1	NP_203746.1	Q8NAA4	A16L2_HUMAN	autophagy related 16-like 2 (S. cerevisiae)	349					autophagy|protein transport	cytoplasm	protein binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(1)|lung(9)	14			BRCA - Breast invasive adenocarcinoma(5;2.73e-06)			CCAACAGCAGCCTCCTGGCCA	0.627000													39	84					1.39924e-13	1.54499e-13	1	1	0
ACSS1	84532	broad.mit.edu	37	20	25002034	25002034	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr20:25002034G>T	ENST00000537502.1	-	4	2381	c.850C>A	c.(850-852)Ccc>Acc	p.P284T	ACSS1_ENST00000542618.1_Missense_Mutation_p.P246T|ACSS1_ENST00000323482.4_Missense_Mutation_p.P367T|ACSS1_ENST00000432802.2_Missense_Mutation_p.P367T			Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	367					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	26					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CCAGCATTGGGATAAACTGGG	0.567000													3	43					1	1	1	1	0
PLOD3	8985	broad.mit.edu	37	7	100850912	100850912	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr7:100850912G>A	ENST00000223127.3	-	17	2280	c.1882C>T	c.(1882-1884)Cgg>Tgg	p.R628W		NM_001084.4	NP_001075.1	O60568	PLOD3_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	628					protein modification process	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	31	Lung NSC(181;0.168)|all_lung(186;0.215)				Succinic acid(DB00139)|Vitamin C(DB00126)	ACATACGTCCGCAGCAGCTGC	0.642000													4	101					0	0	1	0	0
RP11-371F15.3	0	broad.mit.edu	37	4	139790284	139790288	+	RNA	DEL	GGGAG	GGGAG	-	rs113211271		TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr4:139790284_139790288delGGGAG	ENST00000507038.1	-	0	158				RP11-371F15.3_ENST00000511951.1_RNA																							gggaagggatgggaggggagggaag	0.595													3	5	---	---	---	---					
ADAMTS2	9509	broad.mit.edu	37	5	178772259	178772260	+	In_Frame_Ins	INS	-	-	GCA			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr5:178772259_178772260insGCA	ENST00000251582.7	-	1	171_172	c.70_71insTGC	c.(70-72)ccg>cTGCcg	p.23_24insL	ADAMTS2_ENST00000274609.5_In_Frame_Ins_p.23_24insL	NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	23					collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		gagcggcggcggcagcagcagc	0.812													7	11	---	---	---	---					
RP11-525A16.4	0	broad.mit.edu	37	10	112211001	112211001	+	RNA	DEL	A	A	-	rs76804216		TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr10:112211001delA	ENST00000609514.1	-	0	69																											aggaTGAATTaaaaaaaaaaa	0.403													3	4	---	---	---	---					
TAF1C	9013	broad.mit.edu	37	16	84213650	84213651	+	Frame_Shift_Ins	INS	-	-	G			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr16:84213650_84213651insG	ENST00000567759.1	-	13	1782_1783	c.1600_1601insC	c.(1600-1602)cagfs	p.Q534fs	TAF1C_ENST00000541676.1_Frame_Shift_Ins_p.Q441fs|TAF1C_ENST00000378541.4_Frame_Shift_Ins_p.Q534fs|TAF1C_ENST00000570117.1_Frame_Shift_Ins_p.Q202fs|TAF1C_ENST00000566732.1_Frame_Shift_Ins_p.Q508fs|TAF1C_ENST00000341690.6_Frame_Shift_Ins_p.Q440fs	NM_005679.3	NP_005670	Q15572	TAF1C_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa	534					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding	p.Q534fs*19(1)		endometrium(1)|kidney(3)|large_intestine(3)|lung(11)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	26						AGGAAGAGACTGGGGGGGGCCT	0.663													7	87	---	---	---	---					
MYOCD	93649	broad.mit.edu	37	17	12647692	12647694	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr17:12647692_12647694delCAG	ENST00000425538.1	+	8	1110_1112	c.910_912delCAG	c.(910-912)cagdel	p.Q310del	AC005358.1_ENST00000609971.1_In_Frame_Del_p.Q214del|MYOCD_ENST00000395988.1_3'UTR|MYOCD_ENST00000343344.4_In_Frame_Del_p.Q310del	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	310	Gln-rich.				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		AATCCTCAGCcagcagcagcagc	0.596													7	78	---	---	---	---					
ACPT	93650	broad.mit.edu	37	19	51298106	51298106	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr19:51298106delC	ENST00000270593.1	+	10	1050	c.1050delC	c.(1048-1050)ctcfs	p.L350fs	ACPT_ENST00000270594.3_Frame_Shift_Del_p.L257fs	NM_033068.2	NP_149059.1	Q9BZG2	PPAT_HUMAN	acid phosphatase, testicular	350						integral to membrane	acid phosphatase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|skin(3)	11		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		CTCTCAGCCTCCCCGGGTGCC	0.682													7	828	---	---	---	---					
ZDHHC8P1	150244	broad.mit.edu	37	22	23735678	23735679	+	RNA	INS	-	-	G			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chr22:23735678_23735679insG	ENST00000255890.4	-	0	1263																											GGAGGGGCTGTGGGGGGAGGAA	0.678													3	4	---	---	---	---					
MAGEC1	9947	broad.mit.edu	37	X	140994844	140994846	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chrX:140994844_140994846delCCT	ENST00000285879.4	+	4	1940_1942	c.1654_1656delCCT	c.(1654-1656)cctdel	p.P553del	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	553							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCAGAGCCCTCCTCAGGGGG	0.567										HNSCC(15;0.026)			9	442	---	---	---	---					
RBMY2EP	159125	broad.mit.edu	37	Y	23563322	23563323	+	RNA	DEL	AC	AC	-			TCGA-CF-A3MF-01A-12D-A21A-08	TCGA-CF-A3MF-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c66c92d5-df65-46e6-861d-d8a98808e6a3	d6e91f4c-38c0-4393-9cb7-be076663dff3	g.chrY:23563322_23563323delAC	ENST00000444169.1	-	0	86					NR_001574.2																						ATATGAAAATacacacacacac	0.302													3	6	---	---	---	---					
