Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LMBRD2	92255	broad.mit.edu	37	5	36111293	36111293	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr5:36111293C>T	ENST00000296603.4	-	14	2170	c.1708G>A	c.(1708-1710)Gac>Aac	p.D570N		NM_001007527.1	NP_001007528.1	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	570						integral to membrane				breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TTAACTAAGTCTGATGTCATA	0.308000													17	33					0	0	1	0	0
FAM170A	340069	broad.mit.edu	37	5	118970106	118970106	+	Silent	SNP	G	G	A			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr5:118970106G>A	ENST00000515256.1	+	3	835	c.663G>A	c.(661-663)ctG>ctA	p.L221L				A1A519	F170A_HUMAN	family with sequence similarity 170, member A	221						intracellular	zinc ion binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	24						CTGACTGGCTGGTGACCATGG	0.592000													53	88					0	0	1	0	0
TRIM56	81844	broad.mit.edu	37	7	100731813	100731813	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr7:100731813G>T	ENST00000306085.6	+	3	1517	c.1220G>T	c.(1219-1221)gGa>gTa	p.G407V		NM_030961.1	NP_112223.1	Q9BRZ2	TRI56_HUMAN	tripartite motif containing 56	407					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Lung NSC(181;0.136)|all_lung(186;0.182)					AGACAGGGTGGAGTCCAGCCC	0.627000													17	24					6.49762e-13	6.75752e-13	1	1	0
DNM1P47	100216544	broad.mit.edu	37	15	102292726	102292726	+	RNA	SNP	G	G	A	rs150565409	by1000genomes	TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr15:102292726G>A	ENST00000561463.1	+	0	772																											TGGGAACAAGGAGACACTCCT	0.582000													6	28					0	0	1	0	0
TINAG	27283	broad.mit.edu	37	6	54191662	54191662	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr6:54191662G>A	ENST00000259782.4	+	4	668	c.572G>A	c.(571-573)cGc>cAc	p.R191H	TINAG_ENST00000370869.3_Missense_Mutation_p.R187H|TINAG_ENST00000370864.3_Missense_Mutation_p.R173H	NM_014464.3	NP_055279.3	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	191					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity	p.R191H(1)|p.R191L(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(4)|skin(1)	34	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			TTTAAATTTCGCCTTGGCACT	0.373000													19	47					0	0	1	0	0
SGIP1	84251	broad.mit.edu	37	1	67147598	67147598	+	Silent	SNP	C	C	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr1:67147598C>T	ENST00000371037.4	+	15	938	c.861C>T	c.(859-861)tcC>tcT	p.S287S	SGIP1_ENST00000237247.6_Silent_p.S291S|SGIP1_ENST00000371039.1_Intron|SGIP1_ENST00000371035.3_Intron|SGIP1_ENST00000371036.3_Intron	NM_032291.2	NP_115667.2	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting protein 1	287	Pro-rich.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						AACTACCATCCATCAATGACT	0.403000													14	152					0	0	1	0	0
TACC3	10460	broad.mit.edu	37	4	1746695	1746695	+	Silent	SNP	G	G	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr4:1746695G>T	ENST00000313288.4	+	16	2578	c.2472G>T	c.(2470-2472)ctG>ctT	p.L824L		NM_006342.2	NP_006333.1	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing protein 3	824						centrosome				central_nervous_system(1)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	25		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			ACGAGGAGCTGACCAGGATCT	0.607000													3	12					0.004672	0.00473268	1	1	0
PAFAH2	5051	broad.mit.edu	37	1	26308867	26308867	+	Silent	SNP	C	C	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr1:26308867C>T	ENST00000374282.3	-	7	833	c.654G>A	c.(652-654)ctG>ctA	p.L218L	PAFAH2_ENST00000374284.1_Silent_p.L218L|PAFAH2_ENST00000493892.1_5'UTR	NM_000437.3	NP_000428.2	Q99487	PAFA2_HUMAN	platelet-activating factor acetylhydrolase 2, 40kDa	218					lipid catabolic process	cytoplasm	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding			NS(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(2)|urinary_tract(1)	9		Colorectal(325;3.47e-05)|Lung NSC(340;6.23e-05)|all_lung(284;9.48e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-25)|Colorectal(126;3.57e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00155)|GBM - Glioblastoma multiforme(114;0.00717)|READ - Rectum adenocarcinoma(331;0.0649)		TCAAAGTCATCAGATCCAAGC	0.473000													23	40					0	0	1	0	0
SPTAN1	6709	broad.mit.edu	37	9	131386673	131386673	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr9:131386673G>T	ENST00000372739.3	+	46	6009	c.5899G>T	c.(5899-5901)Gag>Tag	p.E1967*	SPTAN1_ENST00000372731.4_Nonsense_Mutation_p.E1962*|SPTAN1_ENST00000358161.5_Nonsense_Mutation_p.E1967*	NM_001130438.2	NP_001123910.1	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1962					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						GTCAGACCTGGAGAAAGCTGC	0.547000													6	21					3.59834e-05	3.69303e-05	1	1	0
CNNM2	54805	broad.mit.edu	37	10	104679304	104679304	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr10:104679304G>A	ENST00000369878.4	+	1	1255	c.1067G>A	c.(1066-1068)gGa>gAa	p.G356E	CNNM2_ENST00000369875.3_Missense_Mutation_p.G356E|CNNM2_ENST00000433628.2_Missense_Mutation_p.G356E	NM_017649.4	NP_060119.3	Q9H8M5	CNNM2_HUMAN	cyclin M2		DUF21.				ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|urinary_tract(1)	19		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		GTCATCTTCGGAGAGATCGTG	0.607000													28	66					0	0	1	0	0
LIPE	3991	broad.mit.edu	37	19	42930736	42930736	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr19:42930736G>A	ENST00000244289.4	-	1	842	c.566C>T	c.(565-567)aCg>aTg	p.T189M	LIPE-AS1_ENST00000594688.1_RNA|LIPE-AS1_ENST00000594624.2_RNA|LIPE-AS1_ENST00000593740.2_RNA|LIPE-AS1_ENST00000457234.2_RNA|LIPE-AS1_ENST00000597203.1_RNA	NM_005357.2	NP_005348.2	Q05469	LIPS_HUMAN	lipase, hormone-sensitive	189					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			breast(2)|endometrium(4)|kidney(7)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		Prostate(69;0.00682)				CTGGACTGGCGTTGTTTGCTT	0.527000													38	73					0	0	1	0	0
INTS1	26173	broad.mit.edu	37	7	1542571	1542571	+	Silent	SNP	C	C	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr7:1542571C>T	ENST00000389470.4	-	4	698	c.699G>A	c.(697-699)ccG>ccA	p.P233P	INTS1_ENST00000404767.3_Silent_p.P105P			Q8N201	INT1_HUMAN	integrator complex subunit 1	105					snRNA processing	integral to membrane|integrator complex|nuclear membrane				autonomic_ganglia(1)|cervix(1)|endometrium(14)|kidney(3)|large_intestine(7)|lung(24)|ovary(1)|prostate(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	62		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		CTTTAATCGACGGAGAAATGG	0.582000													41	135					0	0	1	0	0
CHD1L	9557	broad.mit.edu	37	1	146726621	146726621	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr1:146726621G>C	ENST00000369258.4	+	3	357	c.337G>C	c.(337-339)Gaa>Caa	p.E113Q	CHD1L_ENST00000467213.1_3'UTR|CHD1L_ENST00000369259.3_Intron|CHD1L_ENST00000361293.5_Intron|CHD1L_ENST00000431239.1_Missense_Mutation_p.E113Q	NM_001256336.1|NM_004284.4|NM_024568.2	NP_001243265.1|NP_004275.4|NP_078844.2	Q86WJ1	CHD1L_HUMAN	chromodomain helicase DNA binding protein 1-like	113	Helicase ATP-binding.				chromatin remodeling|DNA repair	cytoplasm|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(15)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33	all_hematologic(923;0.0487)					CTGGAAAGAAGAAATGCAGAG	0.328000													24	52					0	0	1	0	0
KRT12	3859	broad.mit.edu	37	17	39023318	39023318	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr17:39023318C>T	ENST00000251643.4	-	1	144	c.121G>A	c.(121-123)Ggt>Agt	p.G41S		NM_000223.3	NP_000214.1	Q99456	K1C12_HUMAN	keratin 12	41	Gly-rich.|Head.				visual perception	intermediate filament	structural molecule activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(2)	15		Breast(137;0.000301)				CCCCCATAACCACTTCCAACA	0.602000													15	49					0	0	1	0	0
FGFR3	2261	broad.mit.edu	37	4	1803568	1803568	+	Missense_Mutation	SNP	C	C	G	rs121913483		TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr4:1803568C>G	ENST00000340107.4	+	7	1002	c.746C>G	c.(745-747)tCc>tGc	p.S249C	FGFR3_ENST00000412135.2_Missense_Mutation_p.S249C|FGFR3_ENST00000474521.1_3'UTR|FGFR3_ENST00000440486.2_Missense_Mutation_p.S249C|FGFR3_ENST00000481110.2_Missense_Mutation_p.S249C|FGFR3_ENST00000352904.1_Missense_Mutation_p.S249C|FGFR3_ENST00000260795.2_Missense_Mutation_p.S249C	NM_001163213.1	NP_001156685.1	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3	249			S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1204)|p.R248_S249del(1)		NS(1)|central_nervous_system(5)|cervix(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(40)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(9)|skin(339)|soft_tissue(4)|testis(2)|upper_aerodigestive_tract(58)|urinary_tract(2607)	3091		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.736000		1	"""Mis, T"""	"""IGH@, ETV6"""	"""bladder, MM, T-cell lymphoma"""		"""Hypochondroplasia, Thanatophoric dysplasia"""		Saethre-Chotzen syndrome;Muenke syndrome				8	13					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11561875	11561875	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr1:11561875G>A	ENST00000294484.6	+	2	964	c.826G>A	c.(826-828)Gag>Aag	p.E276K	PTCHD2_ENST00000389575.3_Missense_Mutation_p.E276K	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	276					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CTGGCGCATCGAGCTCATCTT	0.657000													10	18					0	0	1	0	0
UHRF1BP1L	23074	broad.mit.edu	37	12	100452269	100452269	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr12:100452269G>A	ENST00000279907.7	-	14	2998	c.2786C>T	c.(2785-2787)tCa>tTa	p.S929L	UHRF1BP1L_ENST00000545232.2_Missense_Mutation_p.S579L	NM_015054.1	NP_055869.1	A0JNW5	UH1BL_HUMAN	UHRF1 binding protein 1-like	929										breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(21)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	50						TCTGTTGTCTGACATATGATT	0.318000													17	52					0	0	1	0	0
KRT15	3866	broad.mit.edu	37	17	39674669	39674669	+	Silent	SNP	G	G	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr17:39674669G>T	ENST00000254043.3	-	1	3996	c.411C>A	c.(409-411)atC>atA	p.I137I	KRT15_ENST00000393981.3_5'UTR|KRT15_ENST00000393976.2_Silent_p.I137I|KRT15_ENST00000393974.3_5'UTR	NM_002275.3	NP_002266	P19012	K1C15_HUMAN	keratin 15	137	Coil 1A.|Rod.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16		Breast(137;0.000286)				ACCAGTCATGGATCTTCACCT	0.542000													46	110					5.48756e-27	6.02859e-27	1	1	0
AGBL1	123624	broad.mit.edu	37	15	87066137	87066137	+	Silent	SNP	C	C	G			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr15:87066137C>G	ENST00000441037.2	+	18	2609	c.2514C>G	c.(2512-2514)ctC>ctG	p.L838L	AGBL1_ENST00000421325.2_Silent_p.L838L|AGBL1_ENST00000389298.3_Silent_p.L569L	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	838					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						AAGGCCTCCTCTACCACCTGA	0.537000													32	60					0	0	1	0	0
TTF2	8458	broad.mit.edu	37	1	117617996	117617996	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr1:117617996C>G	ENST00000369466.4	+	5	834	c.790C>G	c.(790-792)Caa>Gaa	p.Q264E		NM_003594.3	NP_003585.3	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase II						mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(24)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	50	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		GCTTTTGCCTCAAAATGTTCA	0.453000													64	113					0	0	1	0	0
FAM193A	8603	broad.mit.edu	37	4	2695412	2695412	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr4:2695412C>T	ENST00000324666.5	+	14	2381	c.2030C>T	c.(2029-2031)tCg>tTg	p.S677L	FAM193A_ENST00000505311.1_Missense_Mutation_p.S677L|FAM193A_ENST00000382839.3_Missense_Mutation_p.S677L|FAM193A_ENST00000502458.1_Missense_Mutation_p.S699L|FAM193A_ENST00000545951.1_Missense_Mutation_p.S677L	NM_001256666.1	NP_001243595.1	P78312	F193A_HUMAN	family with sequence similarity 193, member A	677										NS(2)|breast(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(12)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	40						CCAGCGCTCTCGCCTGCTGCG	0.627000													32	83					0	0	1	0	0
FAM214A	56204	broad.mit.edu	37	15	52905938	52905938	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr15:52905938G>C	ENST00000261844.7	-	3	285	c.133C>G	c.(133-135)Cat>Gat	p.H45D	FAM214A_ENST00000546305.2_Missense_Mutation_p.H52D	NM_019600.2	NP_062546.2	Q32MH5	K1370_HUMAN	family with sequence similarity 214, member A	45																	GGAGGGCAATGAAAGCTTTCT	0.428000													13	15					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49672361	49672361	+	Silent	SNP	G	G	A			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr16:49672361G>A	ENST00000561648.1	-	4	755	c.702C>T	c.(700-702)acC>acT	p.T234T	ZNF423_ENST00000535559.1_Silent_p.T117T|ZNF423_ENST00000262383.2_Silent_p.T234T|ZNF423_ENST00000562520.1_Silent_p.T174T|ZNF423_ENST00000563137.2_Silent_p.T174T|ZNF423_ENST00000567169.1_Silent_p.T117T|ZNF423_ENST00000562871.1_Silent_p.T174T	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	234					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				GCAGCGAGCTGGTGGAGGAGA	0.577000													17	30					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190068042	190068042	+	Silent	SNP	G	G	A			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr1:190068042G>A	ENST00000367462.3	-	8	1638	c.1407C>T	c.(1405-1407)ctC>ctT	p.L469L	BRINP3_ENST00000534846.1_Silent_p.L367L	NM_199051.1	NP_950252.1			bone morphogenetic protein/retinoic acid inducible neural-specific 3	469																	GCCCCTGGCTGAGCATGTAGC	0.592000													52	78					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802577	185802577	+	Silent	SNP	A	A	G			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr2:185802577A>G	ENST00000302277.6	+	4	3048	c.2454A>G	c.(2452-2454)agA>agG	p.R818R		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	818						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						AAAGAGGCAGATTCCACCCCG	0.393000													14	17					0	0	1	0	0
DCLK1	9201	broad.mit.edu	37	13	36445426	36445426	+	Missense_Mutation	SNP	C	C	T	rs56185003		TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr13:36445426C>T	ENST00000255448.4	-	5	1086	c.875G>A	c.(874-876)cGc>cAc	p.R292H	DCLK1_ENST00000360631.3_Missense_Mutation_p.R292H|DCLK1_ENST00000379892.4_Missense_Mutation_p.R292H	NM_004734.4	NP_004725.1	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	292	Pro/Ser-rich.		R -> H (in dbSNP:rs56185003).		cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(18)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(6)|urinary_tract(1)	64		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		GGTGCTCCTGCGGGATGATGA	0.507000													31	77					0	0	1	0	0
ZBTB32	27033	broad.mit.edu	37	19	36207413	36207413	+	Missense_Mutation	SNP	A	A	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr19:36207413A>T	ENST00000392197.2	+	7	1541	c.1223A>T	c.(1222-1224)cAg>cTg	p.Q408L	ZBTB32_ENST00000262630.3_Missense_Mutation_p.Q408L			Q9Y2Y4	ZBT32_HUMAN	zinc finger and BTB domain containing 32	408					DNA repair|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			large_intestine(5)|lung(1)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	14	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTTTGTCCTCAGCGCTCCCGG	0.667000											OREG0025433	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	77					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140264082	140264082	+	Silent	SNP	C	C	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr5:140264082C>T	ENST00000289272.2	+	1	2229	c.2229C>T	c.(2227-2229)agC>agT	p.S743S	PCDHA5_ENST00000529619.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA13_ENST00000409494.1_Silent_p.S743S	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTGCTCCAGCGCGGCAGGGA	0.677000													7	122					0	0	1	0	0
HTR6	3362	broad.mit.edu	37	1	20005443	20005443	+	Missense_Mutation	SNP	T	T	A			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr1:20005443T>A	ENST00000289753.1	+	3	1372	c.905T>A	c.(904-906)tTc>tAc	p.F302Y		NM_000871.1	NP_000862.1	P50406	5HT6R_HUMAN	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled	302					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	histamine receptor activity|protein binding			endometrium(1)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.81e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00117)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)	Granisetron(DB00889)|Ondansetron(DB00904)|Sertindole(DB06144)	CCAGGCCTCTTCGATGTCCTC	0.617000													43	79					0	0	1	0	0
SLC6A19	340024	broad.mit.edu	37	5	1201811	1201811	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr5:1201811C>T	ENST00000304460.10	+	1	102	c.46C>T	c.(46-48)Ccg>Tcg	p.P16S		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	16					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CGCCCGGATCCCGTCCCTGGC	0.677000													12	19					0	0	1	0	0
GPRIN3	285513	broad.mit.edu	37	4	90169782	90169782	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr4:90169782C>T	ENST00000609438.1	-	2	1998	c.1480G>A	c.(1480-1482)Gag>Aag	p.E494K	GPRIN3_ENST00000333209.4_Missense_Mutation_p.E494K	NM_198281.2	NP_938022.2	Q6ZVF9	GRIN3_HUMAN	GPRIN family member 3											breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(5)|prostate(2)|skin(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		TCTGCAAACTCAGATGGCCTG	0.453000													40	103					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48462746	48462746	+	Silent	SNP	T	T	C			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr3:48462746T>C	ENST00000358536.4	-	8	1970	c.1701A>G	c.(1699-1701)tcA>tcG	p.S567S	PLXNB1_ENST00000358459.4_Silent_p.S567S|PLXNB1_ENST00000456774.1_Silent_p.S567S|PLXNB1_ENST00000296440.6_Silent_p.S567S|PLXNB1_ENST00000448774.2_Intron	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	567					axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGCAGGAATATGACTCCCCTG	0.612000													14	49					0	0	1	0	0
CYP8B1	1582	broad.mit.edu	37	3	42917160	42917160	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr3:42917160C>T	ENST00000316161.4	-	1	473	c.149G>A	c.(148-150)cGg>cAg	p.R50Q	CYP8B1_ENST00000437102.1_Missense_Mutation_p.R50Q|KRBOX1_ENST00000426937.1_Intron|RP11-141M3.5_ENST00000471537.1_RNA	NM_004391.2	NP_004382.2	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B, polypeptide 1	50					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|prostate(2)|skin(5)	23				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		CATATTCTTCCGGAAAGCCAT	0.582000													22	57					0	0	1	0	0
ARHGEF3	50650	broad.mit.edu	37	3	56779360	56779360	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr3:56779360C>T	ENST00000413728.2	-	7	1304	c.761G>A	c.(760-762)cGc>cAc	p.R254H	ARHGEF3_ENST00000495373.1_Missense_Mutation_p.R248H|ARHGEF3_ENST00000338458.4_Missense_Mutation_p.R280H|ARHGEF3_ENST00000497267.1_Missense_Mutation_p.R219H|ARHGEF3_ENST00000496106.1_Missense_Mutation_p.R254H|ARHGEF3_ENST00000296315.3_Missense_Mutation_p.R248H	NM_001128616.1	NP_001122088.1	Q9NR81	ARHG3_HUMAN	Rho guanine nucleotide exchange factor (GEF) 3	248	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	25				KIRC - Kidney renal clear cell carcinoma(284;0.0161)|Kidney(284;0.019)|OV - Ovarian serous cystadenocarcinoma(275;0.193)		ATCTAGTTTGCGGCTAAAGGG	0.468000													4	173					0	0	1	0	0
SMURF1	57154	broad.mit.edu	37	7	98649958	98649958	+	Silent	SNP	G	G	A			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr7:98649958G>A	ENST00000361125.1	-	7	910	c.591C>T	c.(589-591)ttC>ttT	p.F197F	SMURF1_ENST00000361368.2_Silent_p.F197F|SMURF1_ENST00000480055.1_5'UTR	NM_020429.2	NP_065162.1	Q9HCE7	SMUF1_HUMAN	SMAD specific E3 ubiquitin protein ligase 1	197					BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|urinary_tract(1)	25	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			GGGACTCCACGAACCTGCAAT	0.597000													27	47					0	0	1	0	0
ZMYM4	9202	broad.mit.edu	37	1	35858283	35858283	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr1:35858283G>T	ENST00000314607.6	+	17	2844	c.2764G>T	c.(2764-2766)Gat>Tat	p.D922Y	ZMYM4_ENST00000373297.2_Missense_Mutation_p.D833Y	NM_005095.2	NP_005086.2	Q5VZL5	ZMYM4_HUMAN	zinc finger, MYM-type 4	922					multicellular organismal development		DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(16)|ovary(2)|prostate(3)|skin(2)	54		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AATCATCGGTGATGTAAGTTT	0.264000													37	71					2.66277e-13	2.8067e-13	1	1	0
RMI2	116028	broad.mit.edu	37	16	11444539	11444539	+	Silent	SNP	C	C	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr16:11444539C>T	ENST00000572173.1	+	5	792	c.147C>T	c.(145-147)agC>agT	p.S49S	RMI2_ENST00000381820.2_Silent_p.S49S|RMI2_ENST00000576027.1_3'UTR|RMI2_ENST00000312499.5_Silent_p.S112S			Q96E14	RMI2_HUMAN	RecQ mediated genome instability 2	112					DNA replication	nucleus	DNA binding			endometrium(1)|kidney(1)|ovary(1)	3						AGGCCTGCAGCCCTGAGCCCT	0.428000													40	88					0	0	1	0	0
CCDC27	148870	broad.mit.edu	37	1	3677874	3677874	+	Silent	SNP	G	G	A			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr1:3677874G>A	ENST00000294600.2	+	5	825	c.741G>A	c.(739-741)caG>caA	p.Q247Q		NM_152492.2	NP_689705.2	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	247										breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(2)|lung(17)|prostate(1)|skin(2)|urinary_tract(2)	36	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		TGGAGATACAGGTTCAGAAGA	0.577000													12	33					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9984937	9984937	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr16:9984937C>T	ENST00000396573.2	-	5	1337	c.1028G>A	c.(1027-1029)tGg>tAg	p.W343*	GRIN2A_ENST00000330684.3_Nonsense_Mutation_p.W343*|GRIN2A_ENST00000562109.1_Nonsense_Mutation_p.W343*|GRIN2A_ENST00000535259.1_Nonsense_Mutation_p.W186*|GRIN2A_ENST00000404927.2_Nonsense_Mutation_p.W343*|GRIN2A_ENST00000396575.2_Nonsense_Mutation_p.W343*	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	343					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding	p.W343*(1)		NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TTTGCCATCCCATGTAACATT	0.438000													23	43					0	0	1	0	0
KATNA1	11104	broad.mit.edu	37	6	149918645	149918645	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr6:149918645G>A	ENST00000367411.2	-	9	1406	c.1148C>T	c.(1147-1149)tCa>tTa	p.S383L	KATNA1_ENST00000335643.8_Missense_Mutation_p.S307L|KATNA1_ENST00000335647.5_Missense_Mutation_p.S383L|KATNA1_ENST00000494504.1_5'UTR	NM_007044.3	NP_008975.1	O75449	KTNA1_HUMAN	katanin p60 (ATPase containing) subunit A 1	383					cell division|interphase of mitotic cell cycle|mitosis	microtubule|microtubule organizing center|spindle pole	ATP binding|microtubule binding|microtubule-severing ATPase activity|protein heterodimerization activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	12		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;2.95e-12)|GBM - Glioblastoma multiforme(68;0.173)		GAAGATACCTGACGGCAAAGG	0.358000													19	47					0	0	1	0	0
BRF2	55290	broad.mit.edu	37	8	37706159	37706159	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr8:37706159G>A	ENST00000220659.6	-	2	289	c.169C>T	c.(169-171)Cga>Tga	p.R57*	BRF2_ENST00000520601.1_Nonsense_Mutation_p.R57*|BRF2_ENST00000521170.1_Nonsense_Mutation_p.R57*	NM_018310.3	NP_060780.2	Q9HAW0	BRF2_HUMAN	BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit	57					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter|transcription initiation, DNA-dependent	nucleoplasm	protein binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(5)|ovary(1)	12		Lung NSC(58;0.118)|all_lung(54;0.195)	BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;1.81e-10)			CCTGTGCTTCGGGAATATGTT	0.443000													29	49					0	0	1	0	0
ZNF733P	643955	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													5	42					0	0	1	0	0
COIL	8161	broad.mit.edu	37	17	55019443	55019443	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr17:55019443C>T	ENST00000240316.4	-	6	1634	c.1600G>A	c.(1600-1602)Gaa>Aaa	p.E534K		NM_004645.2	NP_004636.1	P38432	COIL_HUMAN	coilin	534						Cajal body|nucleolus	protein C-terminus binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	15	Breast(9;6.15e-08)					GCTCCATTTTCATTGTGATAA	0.418000													30	48					0	0	1	0	0
ESPNP	284729	broad.mit.edu	37	1	17023143	17023143	+	RNA	SNP	C	C	T	rs559507	by1000genomes	TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr1:17023143C>T	ENST00000492551.1	-	0	1720					NR_026567.1																						TGTGGGGCTCCGGACTGGTAA	0.692000													6	18					0	0	1	0	0
CD27	939	broad.mit.edu	37	12	6559751	6559751	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr12:6559751G>A	ENST00000266557.3	+	4	722	c.493G>A	c.(493-495)Gac>Aac	p.D165N	CD27-AS1_ENST00000545339.1_RNA|CD27-AS1_ENST00000399492.2_RNA|CD27_ENST00000541233.1_3'UTR	NM_001242.4	NP_001233	P26842	CD27_HUMAN	CD27 molecule	165					anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway|immunoglobulin mediated immune response|induction of apoptosis|positive regulation of B cell differentiation|positive regulation of JNK cascade|release of cytoplasmic sequestered NF-kappaB	extracellular region|integral to plasma membrane	caspase inhibitor activity|protein binding|transmembrane receptor activity			kidney(1)|large_intestine(5)|lung(1)|urinary_tract(3)	10						GACTCTGGCTGACTTCAGGCA	0.572000													27	51					0	0	1	0	0
AFF4	27125	broad.mit.edu	37	5	132219228	132219228	+	Silent	SNP	A	A	G			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr5:132219228A>G	ENST00000265343.5	-	20	3547	c.3168T>C	c.(3166-3168)ccT>ccC	p.P1056P		NM_014423.3	NP_055238.1	Q9UHB7	AFF4_HUMAN	AF4/FMR2 family, member 4	1056					transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity		SEPT8/AFF4(2)	breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(7)|lung(11)|ovary(3)|pancreas(1)|prostate(3)|skin(2)	43		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTGGAGAAACAGGGGAAGGCA	0.438000													11	30					0	0	1	0	0
OR7D4	125958	broad.mit.edu	37	19	9324997	9324997	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr19:9324997C>T	ENST00000308682.2	-	1	545	c.517G>A	c.(517-519)Gag>Aag	p.E173K		NM_001005191.2	NP_001005191.1	Q8NG98	OR7D4_HUMAN	olfactory receptor, family 7, subfamily D, member 4	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E173K(1)		breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(2)|skin(3)|stomach(1)	26						TGCGGAATCTCAGTGCCTGTG	0.507000													23	55					0	0	1	0	0
RASSF1	11186	broad.mit.edu	37	3	50368087	50368087	+	Silent	SNP	G	G	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr3:50368087G>T	ENST00000359365.4	-	6	1054	c.948C>A	c.(946-948)ctC>ctA	p.L316L	RASSF1_ENST00000327761.3_Silent_p.L246L|RASSF1_ENST00000395126.3_Silent_p.L165L|RASSF1_ENST00000357043.2_Silent_p.L320L	NM_001206957.1|NM_007182.4|NM_170714.1	NP_001193886.1|NP_009113.3|NP_733832.1	Q9NS23	RASF1_HUMAN	Ras association (RalGDS/AF-6) domain family member 1	320	MOAP1-binding.|SARAH.				cell cycle arrest|negative regulation of cell cycle arrest|positive regulation of protein ubiquitination|protein stabilization|Ras protein signal transduction|response to DNA damage stimulus	microtubule|microtubule cytoskeleton|microtubule organizing center|nucleus|spindle pole	identical protein binding|protein binding|protein N-terminus binding|zinc ion binding			lung(2)|ovary(1)|skin(1)|urinary_tract(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000278)|OV - Ovarian serous cystadenocarcinoma(275;0.0015)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GGATCTGGCGGAGGTGCTCCT	0.597000													26	58					8.58068e-18	9.29574e-18	1	1	0
SMAD7	4092	broad.mit.edu	37	18	46448213	46448213	+	Silent	SNP	C	C	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr18:46448213C>T	ENST00000262158.2	-	4	1096	c.810G>A	c.(808-810)aaG>aaA	p.K270K	SMAD7_ENST00000591805.1_Silent_p.K55K|SMAD7_ENST00000585986.1_5'UTR|SMAD7_ENST00000589634.1_Silent_p.K269K	NM_001190821.1|NM_005904.3	NP_001177750.1|NP_005895.1	O15105	SMAD7_HUMAN	SMAD family member 7	270	MH2.				adherens junction assembly|artery morphogenesis|BMP signaling pathway|cellular protein complex localization|negative regulation of BMP signaling pathway|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of peptidyl-serine phosphorylation|negative regulation of peptidyl-threonine phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity|pathway-restricted SMAD protein phosphorylation|positive regulation of anti-apoptosis|positive regulation of cell-cell adhesion|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein stabilization|regulation of activin receptor signaling pathway|response to laminar fluid shear stress|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	centrosome|cytosol|nucleolus|plasma membrane|transcription factor complex	activin binding|beta-catenin binding|I-SMAD binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)	10	Colorectal(1;0.0518)					CCACTCTCGTCTTCTCCTCCC	0.542000													25	25					0	0	1	0	0
TXLNA	200081	broad.mit.edu	37	1	32650145	32650145	+	Silent	SNP	G	G	A			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr1:32650145G>A	ENST00000373609.1	+	3	806	c.525G>A	c.(523-525)ctG>ctA	p.L175L	TXLNA_ENST00000373610.3_Silent_p.L175L			P40222	TXLNA_HUMAN	taxilin alpha	175					cell proliferation|exocytosis	cytoplasm|extracellular region	cytokine activity|high molecular weight B cell growth factor receptor binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				TCACGTTGCTGATGCAGACAT	0.557000													35	82					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189871696	189871696	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr2:189871696G>A	ENST00000304636.3	+	44	3405	c.3235G>A	c.(3235-3237)Gct>Act	p.A1079T	COL3A1_ENST00000317840.5_Intron	NM_000090.3	NP_000081	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	1079	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TCCCGGTCCTGCTGGTTCCCG	0.388000													10	12					0	0	1	0	0
POLR3A	11128	broad.mit.edu	37	10	79745871	79745871	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr10:79745871G>T	ENST00000372371.3	-	22	3085	c.2948C>A	c.(2947-2949)aCc>aAc	p.T983N		NM_007055.3	NP_008986.2	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide A, 155kDa	983					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding			breast(1)|endometrium(7)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			TTTATCTCTGGTTTTCTTGAT	0.413000													50	138					2.74695e-27	3.06089e-27	1	1	0
ABCA4	24	broad.mit.edu	37	1	94496055	94496055	+	Silent	SNP	G	G	A			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr1:94496055G>A	ENST00000370225.3	-	29	4367	c.4281C>T	c.(4279-4281)ttC>ttT	p.F1427F		NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	1427					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CAAGTACCGTGAACTGCTCAC	0.557000													28	51					0	0	1	0	0
SHROOM1	134549	broad.mit.edu	37	5	132160030	132160030	+	Silent	SNP	G	G	C			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr5:132160030G>C	ENST00000378679.3	-	7	2127	c.1323C>G	c.(1321-1323)ctC>ctG	p.L441L	SHROOM1_ENST00000378676.1_Silent_p.L372L|SHROOM1_ENST00000319854.3_Silent_p.L441L	NM_001172700.1	NP_001166171.1	Q2M3G4	SHRM1_HUMAN	shroom family member 1	441					actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			endometrium(1)|kidney(4)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	17			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GACACTCATGGAGCGGGTACT	0.572000													17	19					0	0	1	0	0
TFAP2E	339488	broad.mit.edu	37	1	36055608	36055608	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr1:36055608G>A	ENST00000373235.3	+	5	1071	c.863G>A	c.(862-864)cGc>cAc	p.R288H		NM_178548.3	NP_848643.2	Q6VUC0	AP2E_HUMAN	transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)	288	H-S-H (helix-span-helix), dimerization.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)	2		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				GCTGGCCGTCGCAAGGCCGCC	0.577000													3	33					0	0	1	0	0
REG1P	5969	broad.mit.edu	37	2	79363900	79363900	+	RNA	SNP	G	G	A			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr2:79363900G>A	ENST00000444841.1	-	0	438																											GGAGGTAGAAGATGCAGCAGA	0.463000													10	9					0	0	1	0	0
SHROOM1	134549	broad.mit.edu	37	5	132160503	132160503	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr5:132160503G>C	ENST00000378679.3	-	6	1849	c.1045C>G	c.(1045-1047)Cag>Gag	p.Q349E	SHROOM1_ENST00000378676.1_Intron|SHROOM1_ENST00000319854.3_Missense_Mutation_p.Q349E	NM_001172700.1	NP_001166171.1	Q2M3G4	SHRM1_HUMAN	shroom family member 1	349					actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			endometrium(1)|kidney(4)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	17			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GCCTCTTTCTGAGGCAAGAAC	0.537000													9	14					0	0	1	0	0
DENND1A	57706	broad.mit.edu	37	9	126144610	126144610	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr9:126144610C>T	ENST00000373624.2	-	22	2332	c.2131G>A	c.(2131-2133)Ggc>Agc	p.G711S	DENND1A_ENST00000542603.1_Missense_Mutation_p.G496S|DENND1A_ENST00000473039.1_5'UTR|DENND1A_ENST00000394219.3_Missense_Mutation_p.G722S	NM_020946.1	NP_065997.1	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A	711	Pro-rich.					cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|liver(2)|lung(18)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43						GGCACGATGCCCAGCTCTGGG	0.682000													7	18					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109577201	109577201	+	Splice_Site	SNP	G	G	C			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr12:109577201G>C	ENST00000338432.7	+	2	110		c.e2-1		ACACB_ENST00000377854.5_5'Flank|ACACB_ENST00000377848.3_5'Flank			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta						acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	TCTCCTTACAGATTTTCTGAA	0.418000													23	55					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29599705	29599705	+	Silent	SNP	G	G	C			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr13:29599705G>C	ENST00000431530.3	+	1	958	c.900G>C	c.(898-900)tcG>tcC	p.S300S		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	290						cytoplasm|microtubule	microtubule binding|protein homodimerization activity	p.S300S(1)		NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						CTTTGGCATCGAAGGAAATCC	0.512000													8	20					0	0	1	0	0
RIF1	55183	broad.mit.edu	37	2	152276858	152276858	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr2:152276858G>A	ENST00000243326.5	+	6	1141	c.658G>A	c.(658-660)Gaa>Aaa	p.E220K	RIF1_ENST00000433166.2_Missense_Mutation_p.E220K|RIF1_ENST00000430328.2_Missense_Mutation_p.E220K|RIF1_ENST00000444746.2_Missense_Mutation_p.E220K|RIF1_ENST00000428287.2_Missense_Mutation_p.E220K|RIF1_ENST00000453091.2_Missense_Mutation_p.E220K			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)						cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		GAAACAGCAAGAAATAGCATC	0.413000													28	34					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21508633	21508633	+	Silent	SNP	C	C	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr18:21508633C>T	ENST00000313654.9	+	64	8581	c.8340C>T	c.(8338-8340)ttC>ttT	p.F2780F	LAMA3_ENST00000399516.3_Silent_p.F2724F|LAMA3_ENST00000269217.6_Silent_p.F1171F|LAMA3_ENST00000588770.1_3'UTR|LAMA3_ENST00000587184.1_Silent_p.F1115F	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	2780	Laminin G-like 3.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AATTGAGTTTCACTGATTTGG	0.423000													43	90					0	0	1	0	0
MFSD6L	162387	broad.mit.edu	37	17	8701572	8701572	+	Silent	SNP	G	G	T			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr17:8701572G>T	ENST00000329805.4	-	1	1095	c.867C>A	c.(865-867)gtC>gtA	p.V289V		NM_152599.3	NP_689812.3	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing 6-like	289						integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(7)|skin(4)	17						GCAACCTCCAGACCCACAGGC	0.607000													20	42					6.33239e-15	6.76611e-15	1	1	0
APOB	338	broad.mit.edu	37	2	21247750	21247751	+	Splice_Site	INS	-	-	A	rs35442885		TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr2:21247750_21247751insA	ENST00000399256.4	-	17	2421		c.e17-2		APOB_ENST00000233242.1_Intron			P04114	APOB_HUMAN	apolipoprotein B						cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTGGGCGATCTAAAAAAAAACC	0.530													8	60	---	---	---	---					
CDKN1A	1026	broad.mit.edu	37	6	36651956	36651957	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr6:36651956_36651957insA	ENST00000405375.1	+	2	313_314	c.78_79insA	c.(79-81)agcfs	p.S27fs	CDKN1A_ENST00000448526.2_Frame_Shift_Ins_p.S61fs|CDKN1A_ENST00000244741.5_Frame_Shift_Ins_p.S27fs|CDKN1A_ENST00000373711.2_Frame_Shift_Ins_p.S27fs|CDKN1A_ENST00000478800.1_3'UTR	NM_001220778.1	NP_001207707.1	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	27					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|urinary_tract(5)	15						GCCCAGTGGACAGCGAGCAGCT	0.634													15	34	---	---	---	---					
CCT6P1	643253	broad.mit.edu	37	7	65222951	65222951	+	RNA	DEL	T	T	-			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr7:65222951delT	ENST00000442266.1	+	0	561																											TTTCTGTAACTTTTTTTTTTT	0.323													2	4	---	---	---	---					
CACFD1	11094	broad.mit.edu	37	9	136325291	136325291	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr9:136325291delG	ENST00000316948.4	+	1	183	c.103delG	c.(103-105)gggfs	p.G35fs	CACFD1_ENST00000291722.7_Frame_Shift_Del_p.G35fs|CACFD1_ENST00000540581.1_Frame_Shift_Del_p.G35fs|CACFD1_ENST00000542192.1_Frame_Shift_Del_p.G35fs|CACFD1_ENST00000489519.1_3'UTR	NM_017586.3	NP_060056.1	Q9UGQ2	FLOWR_HUMAN	calcium channel flower domain containing 1	35						integral to membrane											TCGCCTGTCTGGGGTGCTGGG	0.766													2	4	---	---	---	---					
LRRC37A16P	651250	broad.mit.edu	37	17	66141015	66141016	+	RNA	INS	-	-	A			TCGA-CF-A7I0-01A-22D-A34U-08	TCGA-CF-A7I0-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	111978f9-3761-4265-8166-7d5d60c51cff	d5d1e64d-dcbc-48d7-9dcc-574a09af4eab	g.chr17:66141015_66141016insA	ENST00000590019.1	-	0	70																											CCAAGATTTCTACAAAAAAAAA	0.322													7	72	---	---	---	---					
