Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ST3GAL5	8869	broad.mit.edu	37	2	86075319	86075319	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr2:86075319C>G	ENST00000377332.3	-	4	435	c.327G>C	c.(325-327)caG>caC	p.Q109H	ST3GAL5_ENST00000393805.1_Missense_Mutation_p.Q81H|ST3GAL5_ENST00000393808.3_Missense_Mutation_p.Q86H	NM_003896.3	NP_003887.3	Q9UNP4	SIAT9_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	109					ganglioside biosynthetic process|protein glycosylation	integral to Golgi membrane|integral to plasma membrane	lactosylceramide alpha-2,3-sialyltransferase activity|neolactotetraosylceramide alpha-2,3-sialyltransferase activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	15						GAGCATATTTCTGAGCTCTCT	0.408000													4	172					0	0	1	0	0
POLD1	5424	broad.mit.edu	37	19	50905944	50905944	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr19:50905944C>T	ENST00000440232.2	+	8	969	c.916C>T	c.(916-918)Cgc>Tgc	p.R306C	POLD1_ENST00000599857.1_Missense_Mutation_p.R306C|POLD1_ENST00000595904.1_Missense_Mutation_p.R306C	NM_001256849.1|NM_002691.3	NP_001243778.1|NP_002682.2	P28340	DPOD1_HUMAN	polymerase (DNA directed), delta 1, catalytic subunit	306					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(6)|lung(8)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		GCCATGGCAGCGCATTGCGCC	0.672000								DNA polymerases (catalytic subunits)					7	9					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126398323	126398323	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr4:126398323C>T	ENST00000394329.3	+	13	12320	c.12307C>T	c.(12307-12309)Cag>Tag	p.Q4103*	FAT4_ENST00000335110.5_Nonsense_Mutation_p.Q2366*	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4103	Laminin G-like 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TCTTGATGTTCAGCCAAATAG	0.333000													41	86					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56765247	56765247	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr6:56765247G>C	ENST00000370754.5	-	3	388	c.389C>G	c.(388-390)tCt>tGt	p.S130C				Q03001	DYST_HUMAN	dystonin	0	Actin-binding.|CH 1.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ACCTTGAACAGAGTGATAAAA	0.398000													55	126					0	0	1	0	0
NBR1	4077	broad.mit.edu	37	17	41327878	41327878	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr17:41327878C>G	ENST00000422280.1	+	2	521	c.62C>G	c.(61-63)tCt>tGt	p.S21C	NBR1_ENST00000542611.1_Missense_Mutation_p.S21C|NBR1_ENST00000590996.1_Missense_Mutation_p.S21C|NBR1_ENST00000589872.1_Missense_Mutation_p.S21C|NBR1_ENST00000341165.6_Missense_Mutation_p.S21C|NBR1_ENST00000389312.4_Missense_Mutation_p.S21C	NM_031858.2	NP_114064.1	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	21					macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|kidney(4)|large_intestine(1)|lung(7)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	24		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		TTTCTGGTTTCTGATCCAGAA	0.383000													4	9					0	0	1	0	0
HTR4	3360	broad.mit.edu	37	5	147928298	147928298	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr5:147928298G>C	ENST00000360693.3	-	4	424	c.286C>G	c.(286-288)Cgg>Ggg	p.R96G	HTR4_ENST00000517929.1_Missense_Mutation_p.R96G|HTR4_ENST00000314512.6_Missense_Mutation_p.R96G|HTR4_ENST00000377888.3_Missense_Mutation_p.R96G|HTR4_ENST00000520514.1_Missense_Mutation_p.R96G|HTR4_ENST00000362016.2_Missense_Mutation_p.R96G|HTR4_ENST00000521530.1_Missense_Mutation_p.R96G|HTR4_ENST00000354217.2_Missense_Mutation_p.R96G|HTR4_ENST00000521735.1_Missense_Mutation_p.R96G	NM_001040173.2	NP_001035263.1	Q13639	5HT4R_HUMAN	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	96					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity	p.R96W(3)		endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	AGAGATGTCCGAACAAGACAA	0.502000													6	15					0	0	1	0	0
NISCH	11188	broad.mit.edu	37	3	52523380	52523380	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr3:52523380G>A	ENST00000345716.4	+	17	3276	c.3142G>A	c.(3142-3144)Gca>Aca	p.A1048T	NISCH_ENST00000479054.1_Missense_Mutation_p.A1048T	NM_007184.3	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin	1048	Ala/Pro-rich.				apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	33				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		GGAGGTCCCAGCAGAGGCTCT	0.627000													13	28					0	0	1	0	0
SLC22A14	9389	broad.mit.edu	37	3	38347691	38347691	+	Silent	SNP	G	G	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr3:38347691G>C	ENST00000273173.4	+	1	265	c.174G>C	c.(172-174)gcG>gcC	p.A58A	SLC22A14_ENST00000448498.1_Silent_p.A58A	NM_004803.3	NP_004794.2	Q9Y267	S22AE_HUMAN	solute carrier family 22, member 14	58						integral to plasma membrane	organic cation transmembrane transporter activity			central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(5)|prostate(2)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0554)|Kidney(284;0.0696)		TCCTGGATGCGGTGGGGGAGT	0.532000													22	34					0	0	1	0	0
NT5DC3	51559	broad.mit.edu	37	12	104208848	104208848	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr12:104208848G>A	ENST00000392876.3	-	2	300	c.260C>T	c.(259-261)tCa>tTa	p.S87L		NM_001031701.2	NP_001026871.1	Q86UY8	NT5D3_HUMAN	5'-nucleotidase domain containing 3	87							hydrolase activity|metal ion binding			NS(1)|breast(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(15)|ovary(2)|skin(1)|stomach(2)	30						TTCATTGTTTGAGAAAATGGC	0.328000													14	29					0	0	1	0	0
GPRASP2	114928	broad.mit.edu	37	X	101972178	101972178	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chrX:101972178G>C	ENST00000543253.1	+	5	3300	c.2381G>C	c.(2380-2382)gGa>gCa	p.G794A	GPRASP2_ENST00000332262.5_Missense_Mutation_p.G794A|GPRASP2_ENST00000535209.1_Missense_Mutation_p.G794A	NM_001004051.3|NM_001184874.2|NM_001184876.2	NP_001004051.1|NP_001171803.1|NP_001171805.1			G protein-coupled receptor associated sorting protein 2											breast(3)|endometrium(5)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	30						ATAAAAAGTGGAAAGATGTCC	0.313000													5	80					0	0	1	0	0
CCDC94	55702	broad.mit.edu	37	19	4254471	4254471	+	Silent	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr19:4254471G>A	ENST00000262962.7	+	4	458	c.390G>A	c.(388-390)ctG>ctA	p.L130L		NM_018074.4	NP_060544.2	Q9BW85	CCD94_HUMAN	coiled-coil domain containing 94	130										NS(1)|endometrium(1)|lung(2)|ovary(1)|stomach(2)	7				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0348)|STAD - Stomach adenocarcinoma(1328;0.183)		acgaggagCTGAACAACCCCA	0.592000													6	17					0	0	1	0	0
ADPRHL1	113622	broad.mit.edu	37	13	114077230	114077230	+	Silent	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr13:114077230G>A	ENST00000356501.4	-	7	901	c.726C>T	c.(724-726)ctC>ctT	p.L242L	ADPRHL1_ENST00000375418.3_Silent_p.L324L	NM_199162.1	NP_954631.1	Q8NDY3	ARHL1_HUMAN	ADP-ribosylhydrolase like 1	324					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|skin(1)	11	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.0195)|GBM - Glioblastoma multiforme(44;0.116)			CTTTGGGAACGAGGTCCAGGC	0.617000													15	32					0	0	1	0	0
SUCLG2	8801	broad.mit.edu	37	3	67546263	67546263	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr3:67546263G>C	ENST00000307227.5	-	9	1048	c.1021C>G	c.(1021-1023)Caa>Gaa	p.Q341E	SUCLG2_ENST00000493112.1_Missense_Mutation_p.Q341E|SUCLG2_ENST00000492795.1_Missense_Mutation_p.Q341E	NM_003848.3	NP_003839.2	Q96I99	SUCB2_HUMAN	succinate-CoA ligase, GDP-forming, beta subunit	341					succinyl-CoA metabolic process|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|GTP binding|succinate-CoA ligase (GDP-forming) activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(3)|skin(1)	10		Renal(2;0.00294)|Lung NSC(201;0.012)|Hepatocellular(537;0.121)		BRCA - Breast invasive adenocarcinoma(55;3.53e-05)|Epithelial(33;0.000153)	Succinic acid(DB00139)	TGATATACTTGAGCTTCCTTT	0.438000													3	55					0	0	1	0	0
MORC4	79710	broad.mit.edu	37	X	106186426	106186426	+	Silent	SNP	T	T	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chrX:106186426T>C	ENST00000355610.4	-	15	1969	c.1695A>G	c.(1693-1695)aaA>aaG	p.K565K	MORC4_ENST00000255495.7_Silent_p.K565K|MORC4_ENST00000535534.1_Silent_p.K313K	NM_001085354.2|NM_024657.4	NP_001078823.1|NP_078933.3	Q8TE76	MORC4_HUMAN	MORC family CW-type zinc finger 4	565							ATP binding|zinc ion binding			endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	28						CTAGGATCCATTTGTACTTAC	0.423000													26	9					0	0	1	0	0
TELO2	9894	broad.mit.edu	37	16	1552120	1552120	+	Silent	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr16:1552120C>T	ENST00000262319.6	+	12	1824	c.1545C>T	c.(1543-1545)gtC>gtT	p.V515V	TELO2_ENST00000564507.1_3'UTR	NM_016111.3	NP_057195.2	Q9Y4R8	TELO2_HUMAN	telomere maintenance 2	515						chromosome, telomeric region|cytoplasm|membrane|nucleus	protein binding			NS(1)|endometrium(1)|kidney(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	19		Hepatocellular(780;0.219)				CTGCCTACGTCCGGGACTGCG	0.642000													3	39					0	0	1	0	0
DCT	1638	broad.mit.edu	37	13	95121288	95121288	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr13:95121288C>A	ENST00000377028.5	-	2	720	c.307G>T	c.(307-309)Ggc>Tgc	p.G103C	DCT_ENST00000446125.1_Missense_Mutation_p.G103C	NM_001922.3	NP_001913.2	P40126	TYRP2_HUMAN	dopachrome tautomerase	103					epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	50	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		CAATTATAGCCGGCAAAGTTT	0.443000													34	73					1.36615e-20	1.51104e-20	1	1	0
PPP1R3B	79660	broad.mit.edu	37	8	8999029	8999029	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr8:8999029C>T	ENST00000310455.3	-	2	283	c.133G>A	c.(133-135)Gaa>Aaa	p.E45K	RP11-10A14.3_ENST00000520017.1_RNA|PPP1R3B_ENST00000519699.1_Missense_Mutation_p.E45K	NM_001201329.1|NM_024607.3	NP_001188258.1|NP_078883.2	Q86XI6	PPR3B_HUMAN	protein phosphatase 1, regulatory subunit 3B	45					glycogen metabolic process					endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	12				COAD - Colon adenocarcinoma(149;0.0717)|READ - Rectum adenocarcinoma(644;0.241)		CCACTGGCTTCATTCTTGCTG	0.547000													17	37					0	0	1	0	0
TTC30A	92104	broad.mit.edu	37	2	178482542	178482542	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr2:178482542C>A	ENST00000355689.5	-	1	1152	c.888G>T	c.(886-888)atG>atT	p.M296I	AC073834.3_ENST00000357045.4_RNA	NM_152275.3	NP_689488.3	Q86WT1	TT30A_HUMAN	tetratricopeptide repeat domain 30A						cell projection organization	cilium	binding			autonomic_ganglia(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	30			OV - Ovarian serous cystadenocarcinoma(117;0.000423)|Epithelial(96;0.00373)|all cancers(119;0.0169)			CATCCATGTTCATTAGTGCCT	0.502000													5	160					0.00116845	0.00120703	1	1	0
FANCE	2178	broad.mit.edu	37	6	35426205	35426205	+	Silent	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr6:35426205C>G	ENST00000229769.2	+	5	1286	c.1101C>G	c.(1099-1101)ctC>ctG	p.L367L		NM_021922.2	NP_068741.1	Q9HB96	FANCE_HUMAN	Fanconi anemia, complementation group E	367	Interaction with FANCC.				DNA repair	nucleoplasm	protein binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(3)|ovary(1)|skin(2)	13						CCAGAAGCCTCTTTCTTGGAC	0.572000			"""N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				71	131					0	0	1	0	0
GOLGA4	2803	broad.mit.edu	37	3	37368554	37368554	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr3:37368554C>T	ENST00000361924.2	+	14	5551	c.5177C>T	c.(5176-5178)tCc>tTc	p.S1726F	GOLGA4_ENST00000356847.4_Missense_Mutation_p.S1748F|GOLGA4_ENST00000444882.1_Intron	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	1726	Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						GAAGCAGATTCCCAAGGCTGT	0.368000													6	114					0	0	1	0	0
CCNO	10309	broad.mit.edu	37	5	54529236	54529236	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr5:54529236C>T	ENST00000282572.4	-	1	272	c.116G>A	c.(115-117)aGg>aAg	p.R39K		NM_021147.3	NP_066970.3	P22674	CCNO_HUMAN	cyclin O	39					cell cycle|cell division|depyrimidination|regulation of cyclin-dependent protein kinase activity	nucleoplasm	protein kinase binding|uracil DNA N-glycosylase activity			endometrium(1)|lung(3)|skin(1)	5		Lung NSC(810;4.08e-05)|Breast(144;0.0735)|Prostate(74;0.183)	LUSC - Lung squamous cell carcinoma(15;0.142)|Lung(15;0.161)			CGGCTGCTTCCTCCGGAGGCG	0.721000													9	12					0	0	1	0	0
MAST4	375449	broad.mit.edu	37	5	66448516	66448516	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr5:66448516C>G	ENST00000404260.3	+	25	3664	c.3356C>G	c.(3355-3357)tCc>tGc	p.S1119C	MAST4_ENST00000403666.1_Missense_Mutation_p.S927C|MAST4_ENST00000405643.1_Missense_Mutation_p.S937C|MAST4_ENST00000403625.2_Missense_Mutation_p.S1116C|MAST4_ENST00000261569.7_Missense_Mutation_p.S922C			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	1119	Ser-rich.					cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		CATTCCCTGTCCTCGGACCCT	0.522000													5	125					0	0	1	0	0
AGXT	189	broad.mit.edu	37	2	241808420	241808420	+	Silent	SNP	C	C	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr2:241808420C>A	ENST00000307503.3	+	1	525	c.138C>A	c.(136-138)atC>atA	p.I46I		NM_000030.2	NP_000021.1	P21549	SPYA_HUMAN	alanine-glyoxylate aminotransferase	46					glyoxylate metabolic process|protein targeting to peroxisome	mitochondrial matrix|peroxisomal matrix	alanine-glyoxylate transaminase activity|protein homodimerization activity|pyridoxal phosphate binding|serine-pyruvate transaminase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)	18		all_epithelial(40;1.61e-15)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)	Glycine(DB00145)|L-Alanine(DB00160)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	TGCAGATGATCGGGTCCATGA	0.642000													12	34					9.31168e-06	9.75721e-06	1	1	0
PLXNB1	5364	broad.mit.edu	37	3	48457566	48457566	+	Missense_Mutation	SNP	A	A	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr3:48457566A>T	ENST00000358536.4	-	18	3760	c.3491T>A	c.(3490-3492)gTc>gAc	p.V1164D	PLXNB1_ENST00000456774.1_Missense_Mutation_p.V981D|PLXNB1_ENST00000296440.6_Missense_Mutation_p.V1164D|PLXNB1_ENST00000358459.4_Missense_Mutation_p.V981D|PLXNB1_ENST00000448774.2_Intron	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	1164	IPT/TIG 2.				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GATGGAATGGACCTTCGGATC	0.642000													3	7					0	0	1	0	0
TBL2	26608	broad.mit.edu	37	7	72987257	72987257	+	Silent	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr7:72987257G>A	ENST00000305632.5	-	5	883	c.642C>T	c.(640-642)atC>atT	p.I214I	TBL2_ENST00000452475.1_Silent_p.I214I|TBL2_ENST00000432538.1_Silent_p.I178I|TBL2_ENST00000459913.1_5'UTR	NM_012453.2	NP_036585.1	Q9Y4P3	TBL2_HUMAN	transducin (beta)-like 2	214										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	19		Lung NSC(55;0.0659)|all_lung(88;0.152)				TCAGGCTCCAGATGAGGACAG	0.552000													4	25					0	0	1	0	0
UBR2	23304	broad.mit.edu	37	6	42641590	42641590	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr6:42641590C>T	ENST00000372899.1	+	37	4406	c.4148C>T	c.(4147-4149)tCa>tTa	p.S1383L	UBR2_ENST00000372901.1_Missense_Mutation_p.S1383L|UBR2_ENST00000372883.3_3'UTR	NM_015255.2	NP_056070.1	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin 2	1383					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(7)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|skin(5)	64	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			GCATCAGTTTCAGTGGTGCAA	0.338000													17	34					0	0	1	0	0
GAB2	9846	broad.mit.edu	37	11	78128693	78128693	+	Splice_Site	SNP	T	T	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr11:78128693T>C	ENST00000361507.4	-	1	159	c.74A>G	c.(73-75)tAt>tGt	p.Y25C	GAB2_ENST00000526030.1_5'UTR|RP11-452H21.1_ENST00000534168.1_RNA	NM_080491.2	NP_536739.1	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2	25	PH.				osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity		INTS4/GAB2(2)	NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(8)|ovary(5)|skin(1)|upper_aerodigestive_tract(1)	24	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)			cgcACTCACATAGCGCCTCAA	0.781000													2	2					0	0	1	0	0
SPOP	8405	broad.mit.edu	37	17	47685289	47685289	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr17:47685289G>A	ENST00000393331.3	-	9	1131	c.661C>T	c.(661-663)Cgt>Tgt	p.R221C	SPOP_ENST00000504102.1_Missense_Mutation_p.R221C|SPOP_ENST00000347630.2_Missense_Mutation_p.R221C|SPOP_ENST00000393328.2_Missense_Mutation_p.R221C|SPOP_ENST00000503676.1_Missense_Mutation_p.R221C	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	221	BTB.				mRNA processing	nucleus	protein binding			endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						ACCGGAGAACGAGCTACAAAG	0.403000										Prostate(2;0.17)			41	80					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21603978	21603978	+	Missense_Mutation	SNP	T	T	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr7:21603978T>G	ENST00000328843.6	+	6	1188	c.1157T>G	c.(1156-1158)gTt>gGt	p.V386G	DNAH11_ENST00000409508.3_Missense_Mutation_p.V386G			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	386	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						CGGGTTATAGTTTTATTGCAA	0.378000									Kartagener syndrome				13	37					0	0	1	0	0
GAPDH	2597	broad.mit.edu	37	12	6645750	6645750	+	Silent	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr12:6645750C>G	ENST00000229239.5	+	3	786	c.120C>G	c.(118-120)ctC>ctG	p.L40L	GAPDH_ENST00000396859.1_Silent_p.L40L|GAPDH_ENST00000396861.1_Silent_p.L40L|GAPDH_ENST00000396858.1_5'UTR|GAPDH_ENST00000396856.1_5'UTR	NM_002046.4	NP_002037.2	P04406	G3P_HUMAN	glyceraldehyde-3-phosphate dehydrogenase	40	Interaction with WARS.				gluconeogenesis|glycolysis|neuron apoptosis|peptidyl-cysteine S-trans-nitrosylation|protein stabilization	cytosol|membrane|nucleus|perinuclear region of cytoplasm	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|peptidyl-cysteine S-nitrosylase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|lung(4)	7					NADH(DB00157)	TCATTGACCTCAACTACATGG	0.532000													3	86					0	0	1	0	0
L3MBTL2	83746	broad.mit.edu	37	22	41605777	41605777	+	Silent	SNP	G	G	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr22:41605777G>C	ENST00000216237.5	+	2	260	c.102G>C	c.(100-102)cgG>cgC	p.R34R	RP4-756G23.5_ENST00000451176.1_RNA|RP4-756G23.5_ENST00000441316.1_RNA|L3MBTL2_ENST00000489136.1_3'UTR	NM_031488.4	NP_113676.2	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2 (Drosophila)	34					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						ATAGTTTCCGGAGTTATAACA	0.512000													3	74					0	0	1	0	0
EPHA5	2044	broad.mit.edu	37	4	66286281	66286281	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr4:66286281G>T	ENST00000273854.3	-	6	2005	c.1405C>A	c.(1405-1407)Cca>Aca	p.P469T	EPHA5_ENST00000354839.4_Missense_Mutation_p.P469T|EPHA5_ENST00000511294.1_Missense_Mutation_p.P469T|EPHA5_ENST00000432638.2_Missense_Mutation_p.P305T	NM_001281765.1|NM_004439.5	NP_001268694.1|NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	469	Fibronectin type-III 2.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						ACTGGAGATGGAGCTGCAAAA	0.368000										TSP Lung(17;0.13)			4	24					0.184627	0.185474	1	1	0
OR5M10	390167	broad.mit.edu	37	11	56344620	56344620	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr11:56344620C>G	ENST00000526812.2	-	1	643	c.578G>C	c.(577-579)cGt>cCt	p.R193P		NM_001004741.1	NP_001004741.1	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M, member 10	193					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(2)	25						CTTTTTGACACGGGTGTCAGA	0.443000													23	35					0	0	1	0	0
PPARG	5468	broad.mit.edu	37	3	12475550	12475550	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr3:12475550C>T	ENST00000397026.2	+	9	1741	c.1358C>T	c.(1357-1359)aCg>aTg	p.T453M	PPARG_ENST00000539812.1_3'UTR|PPARG_ENST00000397010.2_Missense_Mutation_p.T447M|PPARG_ENST00000397012.2_Missense_Mutation_p.T447M|PPARG_ENST00000397000.1_3'UTR|PPARG_ENST00000287820.6_Missense_Mutation_p.T475M|PPARG_ENST00000309576.6_Missense_Mutation_p.T447M|PPARG_ENST00000397015.2_Missense_Mutation_p.T447M			P37231	PPARG_HUMAN	peroxisome proliferator-activated receptor gamma	475	Ligand-binding.				activation of caspase activity|cell fate commitment|cell maturation|cellular response to insulin stimulus|epithelial cell differentiation|glucose homeostasis|induction of apoptosis|innate immune response|lipid homeostasis|lipoprotein transport|long-chain fatty acid transport|low-density lipoprotein particle receptor biosynthetic process|monocyte differentiation|negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|placenta development|positive regulation of fat cell differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to lipid|response to low-density lipoprotein particle stimulus|white fat cell differentiation	cytosol|nucleoplasm	activating transcription factor binding|arachidonic acid binding|drug binding|enzyme binding|prostaglandin receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding		PAX8/PPARG(117)	breast(2)|endometrium(4)|kidney(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)	20					Atorvastatin(DB01076)|Icosapent(DB00159)|Pioglitazone(DB01132)|Rosiglitazone(DB00412)|Troglitazone(DB00197)	CAGATTGTCACGGAACACGTG	0.527000			T	PAX8	follicular thyroid		"""Insulin resistance ; lipodystrophy, familial partial L;diabetes mellitus, insulin-resistantI, with acanthosis nigricans and hypertension"""						18	40					0	0	1	0	0
SLC39A14	23516	broad.mit.edu	37	8	22275164	22275164	+	Splice_Site	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr8:22275164G>A	ENST00000381237.1	+	8	1267	c.1148G>A	c.(1147-1149)gGa>gAa	p.G383E	SLC39A14_ENST00000289952.5_Splice_Site_p.G383E|SLC39A14_ENST00000240095.6_Splice_Site_p.G383E|SLC39A14_ENST00000359741.5_Splice_Site_p.G383E	NM_001128431.2	NP_001121903.1	Q15043	S39AE_HUMAN	solute carrier family 39 (zinc transporter), member 14	383						endoplasmic reticulum|Golgi apparatus|integral to membrane|lamellipodium|plasma membrane	zinc ion transmembrane transporter activity			NS(1)|endometrium(4)|large_intestine(2)|lung(4)|prostate(1)	12				Colorectal(74;0.019)|COAD - Colon adenocarcinoma(73;0.0731)		GCTGCTGTAGGAGACTTTGTC	0.537000													17	37					0	0	1	0	0
BPIFB3	359710	broad.mit.edu	37	20	31647768	31647768	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr20:31647768C>G	ENST00000375494.3	+	4	458	c.458C>G	c.(457-459)tCa>tGa	p.S153*		NM_182658.1	NP_872599.1	P59826	LPLC3_HUMAN	BPI fold containing family B, member 3	153	Leu-rich.				innate immune response	cytoplasm|extracellular region	lipid binding|protein binding										GCCGTGAGCTCAAGGGGCACA	0.642000													20	33					0	0	1	0	0
KAT8	84148	broad.mit.edu	37	16	31131791	31131791	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr16:31131791C>T	ENST00000543774.2	+	4	753	c.418C>T	c.(418-420)Cgc>Tgc	p.R140C	KAT8_ENST00000219797.4_Missense_Mutation_p.R140C|KAT8_ENST00000448516.2_Missense_Mutation_p.R140C			Q9H7Z6	MYST1_HUMAN	K(lysine) acetyltransferase 8	140					histone H4-K16 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex|MSL complex	histone acetyltransferase activity|metal ion binding|methylated histone residue binding|transcription factor binding										CAAGATCACTCGCAACCAAAA	0.577000													15	22					0	0	1	0	0
NIPA2	81614	broad.mit.edu	37	15	23019854	23019854	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr15:23019854G>A	ENST00000337451.3	-	5	754	c.142C>T	c.(142-144)Caa>Taa	p.Q48*	NIPA2_ENST00000539711.2_Intron|NIPA2_ENST00000359727.4_Intron|NIPA2_ENST00000398014.2_Nonsense_Mutation_p.Q48*|NIPA2_ENST00000398013.3_Nonsense_Mutation_p.Q48*	NM_030922.6	NP_112184.4	Q8N8Q9	NIPA2_HUMAN	non imprinted in Prader-Willi/Angelman syndrome 2	48						early endosome|integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(2)|prostate(4)|skin(1)	15		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;1.48e-06)|Epithelial(43;1.44e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000353)		TGGCCACCTTGACCTGTGAAT	0.323000													17	34					0	0	1	0	0
RAB4B-EGLN2	100529264	broad.mit.edu	37	19	41292605	41292605	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr19:41292605G>A	ENST00000594136.1	+	6	571	c.466G>A	c.(466-468)Gag>Aag	p.E156K	RAB4B-EGLN2_ENST00000601949.1_3'UTR|RAB4B_ENST00000602069.1_3'UTR|RAB4B_ENST00000357052.2_Missense_Mutation_p.E156K|RAB4B_ENST00000594800.1_Missense_Mutation_p.E156K																							TCTCACAGGCGAGAACGTGGA	0.632000													10	22					0	0	1	0	0
USP48	84196	broad.mit.edu	37	1	22056206	22056206	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr1:22056206G>A	ENST00000308271.9	-	10	1939	c.1291C>T	c.(1291-1293)Caa>Taa	p.Q431*	USP48_ENST00000400301.1_Nonsense_Mutation_p.Q431*|USP48_ENST00000529637.1_Nonsense_Mutation_p.Q430*|USP48_ENST00000421625.2_Nonsense_Mutation_p.Q431*	NM_032236.5	NP_115612.4	Q86UV5	UBP48_HUMAN	ubiquitin specific peptidase 48	431					ubiquitin-dependent protein catabolic process	mitochondrion|nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(14)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;4.66e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|OV - Ovarian serous cystadenocarcinoma(117;4.74e-26)|COAD - Colon adenocarcinoma(152;1.3e-05)|GBM - Glioblastoma multiforme(114;1.86e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000614)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00711)|Lung(427;0.0327)|READ - Rectum adenocarcinoma(331;0.0657)|LUSC - Lung squamous cell carcinoma(448;0.0753)		CCTGGAACTTGAACAGTAGTG	0.373000													28	72					0	0	1	0	0
PRKCZ	5590	broad.mit.edu	37	1	2103575	2103575	+	Silent	SNP	C	C	T	rs113412246	byFrequency	TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr1:2103575C>T	ENST00000400921.2	+	9	1277	c.594C>T	c.(592-594)aaC>aaT	p.N198N	PRKCZ_ENST00000479263.1_3'UTR|PRKCZ_ENST00000400920.1_Silent_p.N198N	NM_001033581.1	NP_001028753.1	Q05513	KPCZ_HUMAN	protein kinase C, zeta	381				K -> R (in Ref. 3; BAF83684).	anti-apoptosis|intracellular signal transduction|negative regulation of insulin receptor signaling pathway|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein complex assembly|peptidyl-serine phosphorylation|platelet activation	endosome	ATP binding|protein kinase C activity|zinc ion binding			breast(2)|central_nervous_system(4)|endometrium(1)|large_intestine(5)|lung(5)|stomach(1)	18	all_cancers(77;0.000177)|all_epithelial(69;6.41e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.96e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.3e-23)|GBM - Glioblastoma multiforme(42;2.85e-08)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00294)|BRCA - Breast invasive adenocarcinoma(365;0.00493)|STAD - Stomach adenocarcinoma(132;0.00669)|KIRC - Kidney renal clear cell carcinoma(229;0.0411)|Lung(427;0.213)		AGCTGGACAACGTCCTCCTGG	0.622000													9	29					0	0	1	0	0
WDR44	54521	broad.mit.edu	37	X	117578406	117578406	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chrX:117578406G>A	ENST00000254029.3	+	19	2991	c.2596G>A	c.(2596-2598)Gaa>Aaa	p.E866K	WDR44_ENST00000371825.3_Missense_Mutation_p.E858K|WDR44_ENST00000371822.5_Missense_Mutation_p.E777K	NM_019045.4	NP_061918.3	Q5JSH3	WDR44_HUMAN	WD repeat domain 44	866						cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				breast(4)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	33						TGAAAAATCAGAAGGGAACGA	0.388000													7	47					0	0	1	0	0
HIGD2A	192286	broad.mit.edu	37	5	175816396	175816396	+	Silent	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr5:175816396G>A	ENST00000274787.2	+	2	292	c.219G>A	c.(217-219)caG>caA	p.Q73Q		NM_138820.2	NP_620175.1	Q9BW72	HIG2A_HUMAN	HIG1 hypoxia inducible domain family, member 2A	73	HIG1.					integral to membrane				large_intestine(1)	1	all_cancers(89;0.00522)|Renal(175;0.000269)|Lung NSC(126;0.0105)|all_lung(126;0.0168)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.0965)		GCAACAGCCAGCGCTCTCAGC	0.637000													6	122					0	0	1	0	0
CAMKK1	84254	broad.mit.edu	37	17	3779690	3779690	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr17:3779690C>A	ENST00000381771.2	-	11	1084	c.937G>T	c.(937-939)Gac>Tac	p.D313Y	CAMKK1_ENST00000381769.2_Missense_Mutation_p.D302Y|CAMKK1_ENST00000348335.2_Missense_Mutation_p.D275Y|CAMKK1_ENST00000158166.5_Missense_Mutation_p.D313Y			Q8N5S9	KKCC1_HUMAN	calcium/calmodulin-dependent protein kinase kinase 1, alpha	275	Protein kinase.				synaptic transmission	cytosol|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)	11				LUAD - Lung adenocarcinoma(2;2.11e-05)|Lung(3;0.0176)		GGCTTGATGTCCCTGTGGACG	0.622000													22	46					7.92952e-12	8.51258e-12	1	1	0
SLC26A10	65012	broad.mit.edu	37	12	58019211	58019211	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr12:58019211G>A	ENST00000320442.4	+	13	1803	c.1492G>A	c.(1492-1494)Gat>Aat	p.D498N	SLC26A10_ENST00000379218.2_3'UTR|SLC26A10_ENST00000490243.1_3'UTR	NM_133489.2	NP_597996.2	Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	498	STAS.					integral to membrane	antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(7)	19	Melanoma(17;0.122)					CCGATGTCGAGATGCTAGGAT	0.582000													13	37					0	0	1	0	0
RTEL1	51750	broad.mit.edu	37	20	62324557	62324557	+	Silent	SNP	G	G	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr20:62324557G>C	ENST00000318100.4	+	30	3740	c.2913G>C	c.(2911-2913)ctG>ctC	p.L971L	RTEL1_ENST00000508582.2_Silent_p.L995L|RTEL1_ENST00000370018.3_Silent_p.L971L|RTEL1-TNFRSF6B_ENST00000482936.1_Silent_p.L971L|RTEL1_ENST00000360203.5_Silent_p.L971L|RTEL1_ENST00000370003.1_Silent_p.L216L	NM_001283009.1	NP_001269938.1	Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	971					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			GTATCCAGCTGACAGGACGAG	0.617000													41	46					0	0	1	0	0
NSF	4905	broad.mit.edu	37	17	44791224	44791224	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr17:44791224C>T	ENST00000398238.4	+	15	1740	c.1633C>T	c.(1633-1635)Cct>Tct	p.P545S	NSF_ENST00000575068.1_Missense_Mutation_p.P540S|NSF_ENST00000225282.8_Missense_Mutation_p.P451S	NM_006178.3	NP_006169.2	P46459	NSF_HUMAN	N-ethylmaleimide-sensitive factor	545					protein transport|synaptic transmission	cytosol	ATP binding|metal ion binding			kidney(2)|large_intestine(1)|liver(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	14		Melanoma(429;0.203)	BRCA - Breast invasive adenocarcinoma(9;0.0257)	BRCA - Breast invasive adenocarcinoma(366;0.241)		TGCAGGCCCTCCTCACAGTGG	0.408000													6	19					0	0	1	0	0
ZNF329	79673	broad.mit.edu	37	19	58640856	58640856	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr19:58640856C>A	ENST00000598312.1	-	4	248	c.15G>T	c.(13-15)atG>atT	p.M5I	ZNF329_ENST00000358067.4_Missense_Mutation_p.M5I	NM_024620.3	NP_078896.3	Q86UD4	ZN329_HUMAN	zinc finger protein 329	5					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(10)|lung(5)|skin(3)|urinary_tract(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		TCCGAGTCGTCATTTTCAATC	0.408000													5	140					0.184627	0.185474	1	1	0
IL37	27178	broad.mit.edu	37	2	113676357	113676357	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr2:113676357G>A	ENST00000263326.3	+	5	670	c.628G>A	c.(628-630)Gaa>Aaa	p.E210K	IL37_ENST00000352179.3_Missense_Mutation_p.E189K|IL37_ENST00000349806.3_Missense_Mutation_p.E149K|IL37_ENST00000353225.3_Missense_Mutation_p.E170K|IL37_ENST00000311328.2_Missense_Mutation_p.E184K	NM_014439.3	NP_055254.2	Q9NZH6	IL37_HUMAN	interleukin 37	210					immune response	cytosol|extracellular space|nucleus	cytokine activity|interleukin-1 receptor antagonist activity|interleukin-1 receptor binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(1)|lung(7)|ovary(2)|skin(3)	19						TTGCAAAGCTGAAATGAGCCC	0.423000													13	39					0	0	1	0	0
DNAJC13	23317	broad.mit.edu	37	3	132235271	132235271	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr3:132235271C>T	ENST00000260818.6	+	47	5739	c.5491C>T	c.(5491-5493)Cag>Tag	p.Q1831*		NM_015268.3	NP_056083.3	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1831							heat shock protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|urinary_tract(1)	34						TGCAGGTCGTCAGCTTGTTCT	0.393000													13	36					0	0	1	0	0
SCML1	6322	broad.mit.edu	37	X	17763599	17763599	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chrX:17763599C>A	ENST00000380041.3	+	3	385	c.57C>A	c.(55-57)taC>taA	p.Y19*	SCML1_ENST00000380043.3_Intron|SCML1_ENST00000380045.3_Intron|SCML1_ENST00000398080.1_Intron	NM_001037540.1	NP_001032629.1	Q9UN30	SCML1_HUMAN	sex comb on midleg-like 1 (Drosophila)	19					anatomical structure morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|ovary(1)	10	Hepatocellular(33;0.183)					TACCTACTTACGATGAAGATG	0.289000													8	6					3.09899e-07	3.26287e-07	1	1	0
RGMA	56963	broad.mit.edu	37	15	93595604	93595604	+	Silent	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr15:93595604C>T	ENST00000329082.7	-	3	535	c.264G>A	c.(262-264)cgG>cgA	p.R88R	RGMA_ENST00000425933.2_Silent_p.R72R|RGMA_ENST00000538818.1_5'UTR|RGMA_ENST00000556658.1_5'UTR|RGMA_ENST00000556087.1_Silent_p.R72R|RGMA_ENST00000557420.1_Intron|RGMA_ENST00000543599.1_Silent_p.R72R|RGMA_ENST00000555584.1_5'UTR|RGMA_ENST00000557301.1_Silent_p.R96R|RGMA_ENST00000542321.2_Silent_p.R72R	NM_020211.2	NP_064596	Q96B86	RGMA_HUMAN	repulsive guidance molecule family member a	88					axon guidance	anchored to membrane|endoplasmic reticulum|plasma membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	9	Lung NSC(78;0.0542)|all_lung(78;0.0786)		BRCA - Breast invasive adenocarcinoma(143;0.0312)|OV - Ovarian serous cystadenocarcinoma(32;0.108)			TGCGGGCCGTCCGCCGCGTGC	0.682000													12	8					0	0	1	0	0
ADAM15	8751	broad.mit.edu	37	1	155026830	155026830	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr1:155026830G>C	ENST00000356955.2	+	6	561	c.460G>C	c.(460-462)Gag>Cag	p.E154Q	ADAM15_ENST00000271836.6_Missense_Mutation_p.E154Q|ADAM15_ENST00000368410.2_Intron|ADAM15_ENST00000360674.4_Missense_Mutation_p.E154Q|ADAM15_ENST00000368413.1_Intron|ADAM15_ENST00000531455.1_Missense_Mutation_p.E164Q|ADAM15_ENST00000359280.4_Missense_Mutation_p.E154Q|ADAM15_ENST00000368412.3_Missense_Mutation_p.E154Q|ADAM15_ENST00000449910.2_Missense_Mutation_p.E154Q|ADAM15_ENST00000472434.1_3'UTR|ADAM15_ENST00000355956.2_Missense_Mutation_p.E154Q|ADAM15_ENST00000447332.3_Missense_Mutation_p.E138Q	NM_207197.2	NP_997080.1	Q13444	ADA15_HUMAN	ADAM metallopeptidase domain 15	154					angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(5)|urinary_tract(1)	39	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			CTATACCCTGGAGCAGGGGCC	0.547000													38	74					0	0	1	0	0
CYP4Z1	199974	broad.mit.edu	37	1	47571870	47571870	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr1:47571870G>A	ENST00000334194.3	+	9	1141	c.1138G>A	c.(1138-1140)Gta>Ata	p.V380I	CYP4A22-AS1_ENST00000444042.2_lincRNA	NM_178134.2	NP_835235.1	Q86W10	CP4Z1_HUMAN	cytochrome P450, family 4, subfamily Z, polypeptide 1	380						endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			cervix(1)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	11						CGCACCGGTAGTAAACATATC	0.473000													6	77					0	0	1	0	0
PHF20	51230	broad.mit.edu	37	20	34459715	34459715	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr20:34459715C>T	ENST00000374012.3	+	9	1375	c.1246C>T	c.(1246-1248)Ccc>Tcc	p.P416S	PHF20_ENST00000481202.1_3'UTR|PHF20_ENST00000439301.1_3'UTR			Q9BVI0	PHF20_HUMAN	PHD finger protein 20	416					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			breast(5)|endometrium(1)|kidney(7)|large_intestine(6)|lung(11)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(12;0.00631)|all_lung(11;0.0145)					ACCGACTTCTCCCCTTGTGGA	0.423000													34	70					0	0	1	0	0
ELMO1	9844	broad.mit.edu	37	7	37298882	37298882	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr7:37298882T>C	ENST00000310758.4	-	6	964	c.317A>G	c.(316-318)gAc>gGc	p.D106G	ELMO1_ENST00000448602.1_Missense_Mutation_p.D106G|ELMO1_ENST00000442504.1_Missense_Mutation_p.D106G	NM_001206480.1|NM_014800.10	NP_001193409.1|NP_055615.8	Q92556	ELMO1_HUMAN	engulfment and cell motility 1	106					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						GCTGGCCAAGTCCTTCAGGGC	0.552000													14	36					0	0	1	0	0
FXR2	9513	broad.mit.edu	37	17	7496403	7496403	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr17:7496403C>T	ENST00000250113.7	-	13	1761	c.1427G>A	c.(1426-1428)cGa>cAa	p.R476Q		NM_004860.3	NP_004851.2	P51116	FXR2_HUMAN	fragile X mental retardation, autosomal homolog 2	476						cytosolic large ribosomal subunit	protein binding|RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)	26				READ - Rectum adenocarcinoma(115;0.17)		TTCTTCCCCTCGGGTTGGGGG	0.627000													10	10					0	0	1	0	0
GRB7	2886	broad.mit.edu	37	17	37898867	37898867	+	Silent	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr17:37898867C>T	ENST00000309156.4	+	3	461	c.204C>T	c.(202-204)ccC>ccT	p.P68P	GRB7_ENST00000394211.3_Silent_p.P68P|GRB7_ENST00000445327.2_Silent_p.P91P|GRB7_ENST00000578702.1_3'UTR|GRB7_ENST00000309185.3_Silent_p.P68P|GRB7_ENST00000394209.2_Silent_p.P68P|GRB7_ENST00000394204.1_Silent_p.P68P	NM_005310.3	NP_005301.2	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	68					blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CCTCTATCCCCAACCCCTTCC	0.652000													4	89					0	0	1	0	0
CENPI	2491	broad.mit.edu	37	X	100364525	100364525	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chrX:100364525C>G	ENST00000372927.1	+	4	705	c.428C>G	c.(427-429)tCt>tGt	p.S143C	CENPI_ENST00000218507.5_Missense_Mutation_p.S143C|CENPI_ENST00000423383.1_Missense_Mutation_p.S143C|CENPI_ENST00000372926.1_Missense_Mutation_p.S143C	NM_006733.2	NP_006724.2	Q92674	CENPI_HUMAN	centromere protein I	143					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding	p.S143Y(1)		breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(19)|prostate(1)|skin(2)	30						TCAGAAGATTCTGTGGTTAAG	0.393000													5	131					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100683704	100683704	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr7:100683704G>A	ENST00000306151.4	+	3	9071	c.9007G>A	c.(9007-9009)Gag>Aag	p.E3003K		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3003	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity	p.E3003Q(1)		NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GGCCAGTTCTGAGGCTAGCAC	0.512000													6	324					0	0	1	0	0
ZFYVE21	79038	broad.mit.edu	37	14	104194185	104194185	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr14:104194185G>C	ENST00000216602.6	+	3	404	c.292G>C	c.(292-294)Gag>Cag	p.E98Q	ZFYVE21_ENST00000311141.2_Missense_Mutation_p.E98Q	NM_001198953.1	NP_001185882.1	Q9BQ24	ZFY21_HUMAN	zinc finger, FYVE domain containing 21	98						cytoplasmic membrane-bounded vesicle|focal adhesion	metal ion binding			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|skin(2)	8		Melanoma(154;0.226)		Epithelial(152;0.245)		GCAGTGCGCGGAGTGCGCCCT	0.662000													20	30					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55948763	55948763	+	Silent	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr4:55948763C>G	ENST00000263923.4	-	28	3997	c.3702G>C	c.(3700-3702)gtG>gtC	p.V1234V	RP11-530I17.1_ENST00000511222.1_RNA	NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	1234					angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TTTTTACACTCACAGGCCGGC	0.353000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			19	56					0	0	1	0	0
PIK3R6	146850	broad.mit.edu	37	17	8738745	8738745	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr17:8738745C>A	ENST00000311434.9	-	8	729	c.490G>T	c.(490-492)Gtg>Ttg	p.V164L	PIK3R6_ENST00000434064.2_5'UTR	NM_001010855.2	NP_001010855.1	Q5UE93	PI3R6_HUMAN	phosphoinositide-3-kinase, regulatory subunit 6	164					platelet activation	cytosol											GACGCAGACACCAGCTCAGGA	0.617000													12	26					0.105934	0.107905	1	1	0
MAGI1	9223	broad.mit.edu	37	3	65361561	65361561	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr3:65361561C>T	ENST00000330909.8	-	19	3138	c.3139G>A	c.(3139-3141)Gac>Aac	p.D1047N	MAGI1_ENST00000402939.2_Missense_Mutation_p.D1019N|MAGI1_ENST00000483466.1_Missense_Mutation_p.D1048N|MAGI1_ENST00000497477.2_Intron	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	1048	Interaction with FCHSD2.|PDZ 5.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		CCACAGCGGTCAGCAGGGCTC	0.438000													3	50					0	0	1	0	0
GATA3-AS1	399717	broad.mit.edu	37	10	8092767	8092767	+	RNA	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr10:8092767C>G	ENST00000355358.1	-	0	1859					NR_024256.1																						TAAACACGCTCAAATGACCGC	0.582000													5	13					0	0	1	0	0
HIST1H2AE	3012	broad.mit.edu	37	6	26217236	26217236	+	Silent	SNP	C	C	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr6:26217236C>A	ENST00000303910.2	+	1	72	c.34C>A	c.(34-36)Cgg>Agg	p.R12R		NM_021052.2	NP_066390.1	P04908	H2A1B_HUMAN	histone cluster 1, H2ae	12					nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|skin(2)	10		all_hematologic(11;0.196)				CGGCAAAGCTCGGGCAAAAGC	0.527000													13	30					1.49906e-05	1.5633e-05	1	1	0
CCDC47	57003	broad.mit.edu	37	17	61838298	61838298	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr17:61838298C>T	ENST00000225726.5	-	6	1093	c.711G>A	c.(709-711)atG>atA	p.M237I	CCDC47_ENST00000403162.3_Missense_Mutation_p.M237I|CCDC47_ENST00000582252.1_Missense_Mutation_p.M237I	NM_020198.2	NP_064583.2	Q96A33	CCD47_HUMAN	coiled-coil domain containing 47	237						integral to membrane	protein binding			endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	18						CTGGCCTCATCATCCGGGCCA	0.353000													10	18					0	0	1	0	0
SH3GL1	6455	broad.mit.edu	37	19	4361657	4361657	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr19:4361657G>C	ENST00000269886.3	-	10	1225	c.1047C>G	c.(1045-1047)gaC>gaG	p.D349E	SH3GL1_ENST00000598564.1_Missense_Mutation_p.D285E|SH3GL1_ENST00000417295.2_Missense_Mutation_p.D301E	NM_003025.3	NP_003016.1	Q99961	SH3G1_HUMAN	SH3-domain GRB2-like 1	349	SH3.				central nervous system development|endocytosis|signal transduction	early endosome membrane	lipid binding|protein binding			NS(1)|endometrium(2)|kidney(16)|large_intestine(3)|lung(2)|ovary(2)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0152)|STAD - Stomach adenocarcinoma(1328;0.182)		CCGACTGGCCGTCCAGCATGC	0.657000			T	MLL	AL								3	32					0	0	1	0	0
CASC3	22794	broad.mit.edu	37	17	38320417	38320417	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr17:38320417G>A	ENST00000264645.7	+	7	1695	c.1469G>A	c.(1468-1470)cGa>cAa	p.R490Q		NM_007359.4	NP_031385.2	O15234	CASC3_HUMAN	cancer susceptibility candidate 3	490	Necessary for localization in cytoplasmic stress granules.				mRNA processing|mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|response to stress|RNA splicing	exon-exon junction complex|nuclear speck|perinuclear region of cytoplasm	identical protein binding|RNA binding|ubiquitin protein ligase binding			endometrium(4)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|urinary_tract(2)	16						CGGGAACTTCGAGGTAGGTAT	0.483000													7	13					0	0	1	0	0
TRIP12	9320	broad.mit.edu	37	2	230724018	230724018	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr2:230724018G>C	ENST00000283943.5	-	3	549	c.371C>G	c.(370-372)tCt>tGt	p.S124C	TRIP12_ENST00000409677.1_Missense_Mutation_p.S166C|TRIP12_ENST00000543084.1_Missense_Mutation_p.S166C|TRIP12_ENST00000389044.4_Missense_Mutation_p.S166C|TRIP12_ENST00000389045.3_Intron	NM_001284214.1|NM_004238.1	NP_001271143.1|NP_004229.1	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	124					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(19)|lung(32)|ovary(5)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		TGATTGTGCAGATTTCAGTTG	0.438000													26	77					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222551	140222551	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr5:140222551G>A	ENST00000531613.1	+	1	1645	c.1645G>A	c.(1645-1647)Gtg>Atg	p.V549M	PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA8_ENST00000378123.3_Missense_Mutation_p.V549M|PCDHA4_ENST00000512229.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCAGCAACGTGACGCTGCA	0.687000													8	138					0	0	1	0	0
CAMKK1	84254	broad.mit.edu	37	17	3779703	3779703	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr17:3779703C>G	ENST00000381771.2	-	11	1071	c.924G>C	c.(922-924)aaG>aaC	p.K308N	CAMKK1_ENST00000381769.2_Missense_Mutation_p.K297N|CAMKK1_ENST00000348335.2_Missense_Mutation_p.K270N|CAMKK1_ENST00000158166.5_Missense_Mutation_p.K308N			Q8N5S9	KKCC1_HUMAN	calcium/calmodulin-dependent protein kinase kinase 1, alpha	270	Protein kinase.				synaptic transmission	cytosol|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)	11				LUAD - Lung adenocarcinoma(2;2.11e-05)|Lung(3;0.0176)		TGTGGACGATCTTCTGGCAGT	0.632000													19	38					0	0	1	0	0
C21orf59	56683	broad.mit.edu	37	21	33976579	33976579	+	Silent	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr21:33976579G>A	ENST00000382549.4	-	4	732	c.390C>T	c.(388-390)gcC>gcT	p.A130A	C21orf59_ENST00000290155.3_Silent_p.A130A|C21orf59_ENST00000540881.1_Silent_p.A74A|AP000275.65_ENST00000553001.1_Silent_p.A130A			P57076	CU059_HUMAN	chromosome 21 open reading frame 59	130						cytosol|nucleus				endometrium(2)|large_intestine(1)|prostate(1)|skin(1)	5						CACAGACACCGGCTTCCACTT	0.488000													4	49					0	0	1	0	0
RGMA	56963	broad.mit.edu	37	15	93588794	93588794	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr15:93588794C>A	ENST00000329082.7	-	4	1058	c.787G>T	c.(787-789)Gag>Tag	p.E263*	RGMA_ENST00000425933.2_Nonsense_Mutation_p.E247*|RGMA_ENST00000538818.1_Nonsense_Mutation_p.E154*|RGMA_ENST00000556658.1_Nonsense_Mutation_p.E154*|RGMA_ENST00000557420.1_3'UTR|RGMA_ENST00000543599.1_Nonsense_Mutation_p.E247*|RGMA_ENST00000557301.1_Nonsense_Mutation_p.E271*|RGMA_ENST00000542321.2_Nonsense_Mutation_p.E247*	NM_020211.2	NP_064596	Q96B86	RGMA_HUMAN	repulsive guidance molecule family member a	263					axon guidance	anchored to membrane|endoplasmic reticulum|plasma membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	9	Lung NSC(78;0.0542)|all_lung(78;0.0786)		BRCA - Breast invasive adenocarcinoma(143;0.0312)|OV - Ovarian serous cystadenocarcinoma(32;0.108)			GACACCTTCTCAGTGATCTTC	0.622000													10	26					9.70103e-10	1.03635e-09	1	1	0
ADCK3	56997	broad.mit.edu	37	1	227173038	227173038	+	Silent	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr1:227173038C>G	ENST00000366779.1	+	19	4427	c.1656C>G	c.(1654-1656)gtC>gtG	p.V552V	ADCK3_ENST00000433743.2_Silent_p.V226V|ADCK3_ENST00000458507.2_Silent_p.V273V|ADCK3_ENST00000478406.1_3'UTR|ADCK3_ENST00000366777.3_Silent_p.V552V|ADCK3_ENST00000366778.1_Silent_p.V500V			Q8NI60	ADCK3_HUMAN	aarF domain containing kinase 3	552					cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity			endometrium(1)|kidney(2)|large_intestine(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	9						GCTACGAGGTCAAGGTGAGCA	0.627000													37	58					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56466686	56466686	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr19:56466686C>G	ENST00000291971.3	+	3	1333	c.1262C>G	c.(1261-1263)cCa>cGa	p.P421R	NLRP8_ENST00000590542.1_Missense_Mutation_p.P421R	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	421	NACHT.					cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		CAGTCATGTCCAAATGCCACC	0.488000													3	68					0	0	1	0	0
EPHA4	2043	broad.mit.edu	37	2	222298867	222298867	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr2:222298867G>A	ENST00000281821.2	-	14	2532	c.2491C>T	c.(2491-2493)Caa>Taa	p.Q831*	EPHA4_ENST00000392071.4_Nonsense_Mutation_p.Q780*|EPHA4_ENST00000409854.1_Nonsense_Mutation_p.Q831*|EPHA4_ENST00000409938.1_Nonsense_Mutation_p.Q831*	NM_004438.3	NP_004429.1	P54764	EPHA4_HUMAN	EPH receptor A4	831	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		CTTACATCTTGATTGGACATA	0.408000													9	30					0	0	1	0	0
VPS11	55823	broad.mit.edu	37	11	118948933	118948933	+	Silent	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr11:118948933G>A	ENST00000300793.6	+	12	1851	c.1809G>A	c.(1807-1809)ctG>ctA	p.L603L	VPS11_ENST00000527798.1_3'UTR	NM_021729.4	NP_068375.3	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11 homolog (S. cerevisiae)	604					protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	29	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		CGCGAGAGCTGAAAGCCTTCC	0.542000													7	220					0	0	1	0	0
NOD2	64127	broad.mit.edu	37	16	50745099	50745099	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr16:50745099G>A	ENST00000300589.2	+	4	1382	c.1277G>A	c.(1276-1278)cGt>cAt	p.R426H		NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	426	NACHT.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				GTGACCAGCCGTCCGGCCGCT	0.622000													7	38					0	0	1	0	0
QARS	5859	broad.mit.edu	37	3	49135810	49135810	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr3:49135810C>T	ENST00000306125.6	-	21	2397	c.2060G>A	c.(2059-2061)tGt>tAt	p.C687Y	QARS_ENST00000414533.1_Missense_Mutation_p.C676Y			P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	687					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			breast(1)|endometrium(1)|large_intestine(9)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	GCGAACCTCACACATCAAAGG	0.562000													34	57					0	0	1	0	0
SATB2	23314	broad.mit.edu	37	2	200136952	200136952	+	Silent	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr2:200136952G>A	ENST00000443023.1	-	10	3472	c.2007C>T	c.(2005-2007)gcC>gcT	p.A669A	SATB2_ENST00000417098.1_Silent_p.A728A|SATB2_ENST00000260926.5_Silent_p.A728A|SATB2_ENST00000457245.1_Silent_p.A728A|SATB2_ENST00000428695.1_Silent_p.A610A			Q9UPW6	SATB2_HUMAN	SATB homeobox 2	728						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(40)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						GGTCAATTTCGGCAGGTGCTG	0.443000													4	92					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178952085	178952085	+	Missense_Mutation	SNP	A	A	G	rs121913279		TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr3:178952085A>G	ENST00000263967.3	+	21	3297	c.3140A>G	c.(3139-3141)cAt>cGt	p.H1047R		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1387)|p.H1047L(194)|p.H1047P(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378000	H1047L(EFM19_BREAST)|H1047R(BT20_BREAST)|H1047R(CAL29_URINARY_TRACT)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(HCC1954_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(MCAS_OVARY)|H1047R(MDAMB453_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(RKO_LARGE_INTESTINE)|H1047R(SKOV3_OVARY)|H1047R(T47D_BREAST)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			18	36					0	0	1	0	0
CYP4Z2P	163720	broad.mit.edu	37	1	47325287	47325287	+	RNA	SNP	T	T	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr1:47325287T>C	ENST00000505841.1	-	0	1204					NR_002788.2																						AATCCAAACATAGCTGCATTG	0.388000													3	49					0	0	1	0	0
PRKCZ	5590	broad.mit.edu	37	1	2103551	2103551	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr1:2103551C>G	ENST00000400921.2	+	9	1253	c.570C>G	c.(568-570)atC>atG	p.I190M	PRKCZ_ENST00000479263.1_3'UTR|PRKCZ_ENST00000400920.1_Missense_Mutation_p.I190M	NM_001033581.1	NP_001028753.1	Q05513	KPCZ_HUMAN	protein kinase C, zeta	373					anti-apoptosis|intracellular signal transduction|negative regulation of insulin receptor signaling pathway|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein complex assembly|peptidyl-serine phosphorylation|platelet activation	endosome	ATP binding|protein kinase C activity|zinc ion binding			breast(2)|central_nervous_system(4)|endometrium(1)|large_intestine(5)|lung(5)|stomach(1)	18	all_cancers(77;0.000177)|all_epithelial(69;6.41e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.96e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.3e-23)|GBM - Glioblastoma multiforme(42;2.85e-08)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00294)|BRCA - Breast invasive adenocarcinoma(365;0.00493)|STAD - Stomach adenocarcinoma(132;0.00669)|KIRC - Kidney renal clear cell carcinoma(229;0.0411)|Lung(427;0.213)		GGGGGATCATCTACAGGGACC	0.627000													9	25					0	0	1	0	0
CSNK1D	1453	broad.mit.edu	37	17	80210377	80210377	+	Silent	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr17:80210377C>T	ENST00000314028.6	-	5	1018	c.669G>A	c.(667-669)caG>caA	p.Q223Q	CSNK1D_ENST00000392334.2_Silent_p.Q223Q|CSNK1D_ENST00000578904.1_5'UTR|CSNK1D_ENST00000398519.5_Silent_p.Q223Q	NM_001893.4	NP_001884.2	P48730	KC1D_HUMAN	casein kinase 1, delta	223	Protein kinase.				circadian regulation of gene expression|DNA repair|G2/M transition of mitotic cell cycle|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|regulation of circadian rhythm|Wnt receptor signaling pathway	centrosome|cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|large_intestine(2)|lung(7)	11	Breast(20;0.00136)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0155)			TTTCGTATTTCTGTCTCTTGG	0.522000													49	50					0	0	1	0	0
MED23	9439	broad.mit.edu	37	6	131917800	131917800	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr6:131917800G>A	ENST00000403834.3	-	21	2827	c.2654C>T	c.(2653-2655)gCc>gTc	p.A885V	MED23_ENST00000354577.4_Missense_Mutation_p.A885V|MED23_ENST00000368068.3_Missense_Mutation_p.A879V|MED23_ENST00000368060.3_Missense_Mutation_p.A879V|MED23_ENST00000545957.1_Missense_Mutation_p.A520V|MED23_ENST00000368058.1_Missense_Mutation_p.A885V			Q9ULK4	MED23_HUMAN	mediator complex subunit 23	879					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(12)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	44	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		ACAAACCTGGGCTTCATTTCC	0.383000													4	46					0	0	1	0	0
EPHA5	2044	broad.mit.edu	37	4	66286280	66286280	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr4:66286280G>T	ENST00000273854.3	-	6	2006	c.1406C>A	c.(1405-1407)cCa>cAa	p.P469Q	EPHA5_ENST00000354839.4_Missense_Mutation_p.P469Q|EPHA5_ENST00000511294.1_Missense_Mutation_p.P469Q|EPHA5_ENST00000432638.2_Missense_Mutation_p.P305Q	NM_001281765.1|NM_004439.5	NP_001268694.1|NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	469	Fibronectin type-III 2.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						GACTGGAGATGGAGCTGCAAA	0.368000										TSP Lung(17;0.13)			4	23					0.184627	0.185474	1	1	0
ADAMTS14	140766	broad.mit.edu	37	10	72434641	72434641	+	Nonsense_Mutation	SNP	G	G	T	rs144062605	by1000genomes	TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr10:72434641G>T	ENST00000373208.1	+	2	412	c.412G>T	c.(412-414)Gag>Tag	p.E138*	ADAMTS14_ENST00000373207.1_Nonsense_Mutation_p.E138*	NM_139155.2	NP_631894.2	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 14	138					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(15)|ovary(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50						GGAGTGGCAGGAGGATTTTCG	0.577000													15	17					0.00316338	0.00325249	1	1	0
BAGE2	85319	broad.mit.edu	37	21	11039343	11039343	+	RNA	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr21:11039343C>T	ENST00000470054.1	-	0	860									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATTTGATCTTCGCCACAAATA	0.383000													12	243					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50918166	50918166	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr18:50918166A>G	ENST00000442544.2	+	17	3213	c.2597A>G	c.(2596-2598)gAc>gGc	p.D866G	DCC_ENST00000412726.1_Missense_Mutation_p.D694G|DCC_ENST00000581580.1_Missense_Mutation_p.D501G	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	866	Fibronectin type-III 5.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		AGCTGGGCAGACAACTCTGTC	0.542000													5	41					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24413161	24413161	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr1:24413161C>T	ENST00000330966.7	-	15	1936	c.1774G>A	c.(1774-1776)Gaa>Aaa	p.E592K	MYOM3_ENST00000329601.7_Missense_Mutation_p.E591K|MYOM3_ENST00000374434.3_Missense_Mutation_p.E591K|MYOM3_ENST00000475306.1_5'UTR|RP11-293P20.2_ENST00000439239.2_RNA			Q5VTT5	MYOM3_HUMAN	myomesin 3	591	Fibronectin type-III 2.									NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		GCGATGGGTTCGCTGGGCTCC	0.632000													5	48					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77742607	77742607	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr13:77742607C>G	ENST00000407578.2	-	40	6336	c.6070G>C	c.(6070-6072)Gag>Cag	p.E2024Q	MYCBP2_ENST00000357337.6_Missense_Mutation_p.E1986Q|MYCBP2_ENST00000360084.5_5'UTR|MYCBP2_ENST00000544440.2_Missense_Mutation_p.E1986Q	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	1986					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TGCTCACTCTCTATGACAGCA	0.493000													31	46					0	0	1	0	0
CLSTN3	9746	broad.mit.edu	37	12	7303257	7303257	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr12:7303257G>A	ENST00000537408.1	+	14	2937	c.2399G>A	c.(2398-2400)cGt>cAt	p.R800H	CLSTN3_ENST00000266546.6_Missense_Mutation_p.R788H			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	788					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						ATGAATGGCCGTTACTCCAGC	0.542000													4	62					0	0	1	0	0
CCNF	899	broad.mit.edu	37	16	2487194	2487194	+	Silent	SNP	C	C	T	rs148977637		TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr16:2487194C>T	ENST00000397066.4	+	5	499	c.411C>T	c.(409-411)ctC>ctT	p.L137L		NM_001761.2	NP_001752.2	P41002	CCNF_HUMAN	cyclin F	137					cell division|mitosis|negative regulation of centrosome duplication|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	centriole|nucleus|SCF ubiquitin ligase complex	protein binding			breast(3)|central_nervous_system(1)|kidney(4)|large_intestine(2)|lung(5)|prostate(4)|skin(1)	20		Ovarian(90;0.17)				TCTTCAGTCTCGCTGAGCGGC	0.612000													6	68					0	0	1	0	0
MAP4K3	8491	broad.mit.edu	37	2	39552953	39552953	+	Splice_Site	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr2:39552953C>T	ENST00000263881.3	-	11	1050		c.e11-1		MAP4K3_ENST00000341681.5_Splice_Site|MAP4K3_ENST00000536018.1_Splice_Site|MAP4K3_ENST00000437545.1_Splice_Site	NM_003618.3	NP_003609.2	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase kinase 3						JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_hematologic(82;0.211)				ACTATTTGACCTAAGAAATTT	0.274000													9	31					0	0	1	0	0
NYAP2	57624	broad.mit.edu	37	2	226447597	226447597	+	Silent	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr2:226447597C>T	ENST00000272907.6	+	4	1877	c.1464C>T	c.(1462-1464)gtC>gtT	p.V488V	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	488																	CCAAGATGGTCAACGCCGCGG	0.677000													8	25					0	0	1	0	0
CHPF2	54480	broad.mit.edu	37	7	150935045	150935045	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr7:150935045G>A	ENST00000035307.2	+	4	3110	c.1597G>A	c.(1597-1599)Gaa>Aaa	p.E533K	CHPF2_ENST00000495645.1_Missense_Mutation_p.E525K	NM_019015.1	NP_061888.1	Q9P2E5	CHPF2_HUMAN	chondroitin polymerizing factor 2	533						Golgi cisterna membrane|integral to membrane	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(4)|prostate(1)|skin(3)	17						CGGGCCACGAGAAGGTGGCCG	0.627000													17	42					0	0	1	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23833308	23833308	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr4:23833308C>T	ENST00000264867.2	-	3	420	c.301G>A	c.(301-303)Gtg>Atg	p.V101M	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	101					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				TCTTCATCCACAGGGAGACTG	0.493000													9	320					0	0	1	0	0
WDR78	79819	broad.mit.edu	37	1	67293551	67293551	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr1:67293551G>C	ENST00000371026.3	-	14	2111	c.2056C>G	c.(2056-2058)Cac>Gac	p.H686D	RP11-342H21.2_ENST00000456389.1_RNA|WDR78_ENST00000431318.1_Intron	NM_024763.4	NP_079039.4	Q5VTH9	WDR78_HUMAN	WD repeat domain 78	686										NS(1)|endometrium(3)|kidney(6)|large_intestine(6)|lung(10)|ovary(3)|skin(3)	32						GAACATTTGTGAATATGACCT	0.313000													18	173					0	0	1	0	0
RGMA	56963	broad.mit.edu	37	15	93588668	93588668	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr15:93588668C>T	ENST00000329082.7	-	4	1184	c.913G>A	c.(913-915)Gag>Aag	p.E305K	RGMA_ENST00000425933.2_Missense_Mutation_p.E289K|RGMA_ENST00000538818.1_Missense_Mutation_p.E196K|RGMA_ENST00000556658.1_Missense_Mutation_p.E196K|RGMA_ENST00000557420.1_3'UTR|RGMA_ENST00000543599.1_Missense_Mutation_p.E289K|RGMA_ENST00000557301.1_Missense_Mutation_p.E313K|RGMA_ENST00000542321.2_Missense_Mutation_p.E289K	NM_020211.2	NP_064596	Q96B86	RGMA_HUMAN	repulsive guidance molecule family member a	305					axon guidance	anchored to membrane|endoplasmic reticulum|plasma membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	9	Lung NSC(78;0.0542)|all_lung(78;0.0786)		BRCA - Breast invasive adenocarcinoma(143;0.0312)|OV - Ovarian serous cystadenocarcinoma(32;0.108)			TCCCAGTCCTCCACAGCATTG	0.637000													4	16					0	0	1	0	0
RC3H2	54542	broad.mit.edu	37	9	125621070	125621070	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr9:125621070C>G	ENST00000373670.1	-	11	2761	c.2161G>C	c.(2161-2163)Gat>Cat	p.D721H	RC3H2_ENST00000423239.2_Missense_Mutation_p.D721H|RC3H2_ENST00000357244.2_Missense_Mutation_p.D721H			Q9HBD1	RC3H2_HUMAN	ring finger and CCCH-type domains 2	721						cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|large_intestine(4)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						TGCATCACATCCATTGGAGGT	0.453000													19	30					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47817295	47817295	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr21:47817295G>A	ENST00000359568.5	+	22	4440	c.4333G>A	c.(4333-4335)Gaa>Aaa	p.E1445K	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	1445					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					TGAGTTAGAAGAACAGCTGTC	0.577000													23	29					0	0	1	0	0
FUT1	2523	broad.mit.edu	37	19	49253609	49253609	+	Silent	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr19:49253609G>A	ENST00000310160.3	-	4	1904	c.930C>T	c.(928-930)ttC>ttT	p.F310F		NM_000148.3	NP_000139.1	P19526	FUT1_HUMAN	fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)	310					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to plasma membrane|membrane fraction	galactoside 2-alpha-L-fucosyltransferase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(3)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	17		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000135)|all cancers(93;0.000354)|Epithelial(262;0.0191)|GBM - Glioblastoma multiforme(486;0.0222)		CCCAGAAGCCGAAGGTGCCAA	0.572000													17	36					0	0	1	0	0
MROH7-TTC4	100527960	broad.mit.edu	37	1	55118794	55118794	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr1:55118794G>C	ENST00000414150.2	+	3	473	c.195G>C	c.(193-195)ttG>ttC	p.L65F	MROH7_ENST00000472987.1_3'UTR|MROH7_ENST00000454855.2_Intron|MROH7_ENST00000395690.2_Missense_Mutation_p.L65F|MROH7_ENST00000545244.1_Intron|MROH7_ENST00000339553.5_Missense_Mutation_p.L65F|MROH7_ENST00000409996.1_Intron|MROH7_ENST00000421030.2_Missense_Mutation_p.L65F																							ATGATTCTTTGAGTCCAGTCT	0.557000													18	47					0	0	1	0	0
ASXL2	55252	broad.mit.edu	37	2	25978935	25978935	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr2:25978935C>T	ENST00000435504.4	-	10	1281	c.988G>A	c.(988-990)Gaa>Aaa	p.E330K	ASXL2_ENST00000272341.4_Missense_Mutation_p.E70K|ASXL2_ENST00000404843.1_Missense_Mutation_p.E70K|ASXL2_ENST00000336112.4_Missense_Mutation_p.E302K			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	330					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding	p.E70Q(1)|p.E330Q(1)		NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTGAAGAATTCATTGTTAAGG	0.448000													27	35					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61526407	61526407	+	Silent	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr20:61526407C>T	ENST00000266070.4	-	9	2650	c.2325G>A	c.(2323-2325)gcG>gcA	p.A775A	DIDO1_ENST00000395340.1_Silent_p.A775A|DIDO1_ENST00000395343.1_Silent_p.A775A|DIDO1_ENST00000395335.2_Silent_p.A775A	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	775	TFIIS central.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					TCACAGATCTCGCTGGCCTCT	0.488000													6	230					0	0	1	0	0
PHACTR1	221692	broad.mit.edu	37	6	13206063	13206063	+	Silent	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr6:13206063G>A	ENST00000379350.1	+	7	810	c.681G>A	c.(679-681)gtG>gtA	p.V227V	PHACTR1_ENST00000332995.7_Silent_p.V227V|PHACTR1_ENST00000457702.2_Silent_p.V82V|PHACTR1_ENST00000379345.2_Intron			Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	227						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	26	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			GCGCCCCTGTGAAATTGCCTT	0.562000													17	38					0	0	1	0	0
SH3KBP1	30011	broad.mit.edu	37	X	19606875	19606875	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chrX:19606875A>G	ENST00000397821.3	-	12	1474	c.1184T>C	c.(1183-1185)gTt>gCt	p.V395A	SH3KBP1_ENST00000379698.4_Missense_Mutation_p.V358A|SH3KBP1_ENST00000379716.1_Missense_Mutation_p.V157A|SH3KBP1_ENST00000541422.1_Missense_Mutation_p.V134A|SH3KBP1_ENST00000379697.3_Missense_Mutation_p.V439A	NM_031892.2	NP_114098.1	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1	395	Pro-rich.				apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|skin(4)	29						TATGGCAGGAACGGAGGGCTT	0.502000													6	79					0	0	1	0	0
PI4KA	5297	broad.mit.edu	37	22	21156327	21156327	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr22:21156327G>A	ENST00000255882.6	-	14	1744	c.1658C>T	c.(1657-1659)tCg>tTg	p.S553L	PI4KA_ENST00000572273.1_Missense_Mutation_p.S495L	NM_058004.3	NP_477352.3	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase, catalytic, alpha	495					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(8)|kidney(9)|large_intestine(19)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|salivary_gland(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	79	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			CTTCTTACCCGACATGACGTT	0.463000													13	46					0	0	1	0	0
PRRC2A	7916	broad.mit.edu	37	6	31598376	31598376	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr6:31598376C>T	ENST00000376033.2	+	15	2497	c.2263C>T	c.(2263-2265)Ccc>Tcc	p.P755S	PRRC2A_ENST00000376007.4_Missense_Mutation_p.P755S	NM_004638.3	NP_004629.3	P48634	PRC2A_HUMAN	proline-rich coiled-coil 2A	755	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						AGGCCTAGTTCCCCGAGAGCG	0.522000													12	30					0	0	1	0	0
FAM184A	79632	broad.mit.edu	37	6	119297190	119297190	+	Silent	SNP	G	G	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr6:119297190G>C	ENST00000338891.7	-	12	2918	c.2475C>G	c.(2473-2475)ctC>ctG	p.L825L	FAM184A_ENST00000368475.4_Silent_p.L705L|FAM184A_ENST00000352896.5_Silent_p.L705L|FAM184A_ENST00000521531.1_Silent_p.L825L|RP11-351A11.1_ENST00000518570.1_RNA	NM_024581.4	NP_078857.5	Q8NB25	F184A_HUMAN	family with sequence similarity 184, member A	825										breast(2)|central_nervous_system(2)|endometrium(2)|kidney(5)|large_intestine(19)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(5)	52						GTTGATGGTTGAGTTCTGAGC	0.338000													19	30					0	0	1	0	0
AZI1	22994	broad.mit.edu	37	17	79164521	79164521	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr17:79164521C>T	ENST00000269392.4	-	24	3281	c.3034G>A	c.(3034-3036)Gag>Aag	p.E1012K	AZI1_ENST00000450824.2_Missense_Mutation_p.E1009K|AZI1_ENST00000575907.1_Missense_Mutation_p.E976K|AZI1_ENST00000374782.3_Missense_Mutation_p.E973K	NM_014984.2	NP_055799.2	Q9UPN4	AZI1_HUMAN	5-azacytidine induced 1	1012					cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centrosome|cytosol|intracellular membrane-bounded organelle				breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(1)|lung(12)|ovary(2)|prostate(3)|urinary_tract(5)	36	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			GTCTCCTCCTCAGAGGCTGCC	0.706000													8	8					0	0	1	0	0
HIP1	3092	broad.mit.edu	37	7	75182856	75182856	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr7:75182856C>T	ENST00000336926.6	-	22	2217	c.2191G>A	c.(2191-2193)Gaa>Aaa	p.E731K	HIP1_ENST00000434438.2_Missense_Mutation_p.E731K	NM_005338.5	NP_005329.3	O00291	HIP1_HUMAN	huntingtin interacting protein 1	731					activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						GCGAGGGTTTCCCTGCCATAC	0.552000			T	PDGFRB	CMML								11	36					0	0	1	0	0
ANKRD20A4	728747	broad.mit.edu	37	9	69420336	69420336	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr9:69420336C>T	ENST00000357336.3	+	13	1507	c.1226C>T	c.(1225-1227)tCt>tTt	p.S409F		NM_001098805.1	NP_001092275.1	Q4UJ75	A20A4_HUMAN	ankyrin repeat domain 20 family, member A4	409										breast(1)|large_intestine(1)|liver(1)|lung(9)|pancreas(2)|skin(2)	16						AGTACATCTTCTGCTGCTGCT	0.333000													26	49					0	0	1	0	0
TBC1D12	23232	broad.mit.edu	37	10	96162370	96162370	+	Translation_Start_Site	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr10:96162370G>A	ENST00000225235.4	+	0	110					NM_015188.1	NP_056003.1	O60347	TBC12_HUMAN	TBC1 domain family, member 12							intracellular	Rab GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	20		Colorectal(252;0.0429)				CCCACCCCCAGATGGTGGGTC	0.697000													9	11					0	0	1	0	0
IL37	27178	broad.mit.edu	37	2	113676221	113676221	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr2:113676221G>A	ENST00000263326.3	+	5	534	c.492G>A	c.(490-492)tgG>tgA	p.W164*	IL37_ENST00000352179.3_Nonsense_Mutation_p.W143*|IL37_ENST00000349806.3_Nonsense_Mutation_p.W103*|IL37_ENST00000353225.3_Nonsense_Mutation_p.W124*|IL37_ENST00000311328.2_Nonsense_Mutation_p.W138*	NM_014439.3	NP_055254.2	Q9NZH6	IL37_HUMAN	interleukin 37	164			W -> R (in dbSNP:rs2708947).		immune response	cytosol|extracellular space|nucleus	cytokine activity|interleukin-1 receptor antagonist activity|interleukin-1 receptor binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(1)|lung(7)|ovary(2)|skin(3)	19						TGGGCTCCTGGAACATGCTGG	0.522000													16	39					0	0	1	0	0
DGKI	9162	broad.mit.edu	37	7	137284588	137284588	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr7:137284588G>C	ENST00000453654.2	-	11	870	c.331C>G	c.(331-333)Cag>Gag	p.Q111E	DGKI_ENST00000446122.1_Missense_Mutation_p.Q411E|DGKI_ENST00000424189.2_Missense_Mutation_p.Q411E|DGKI_ENST00000288490.5_Missense_Mutation_p.Q411E			O75912	DGKI_HUMAN	diacylglycerol kinase, iota						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						GGCCCTTCCTGAGAAAGATCA	0.383000													3	69					0	0	1	0	0
GLTP	51228	broad.mit.edu	37	12	110318078	110318078	+	Splice_Site	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr12:110318078G>A	ENST00000318348.4	-	1	215	c.102C>T	c.(100-102)ttC>ttT	p.F34F	GLTP_ENST00000544393.1_Splice_Site_p.F34F	NM_016433.3	NP_057517.1	Q9NZD2	GLTP_HUMAN	glycolipid transfer protein	34						cytoplasm	glycolipid binding|glycolipid transporter activity			endometrium(1)|kidney(1)|lung(1)|upper_aerodigestive_tract(1)	4		Lung NSC(355;2.38e-06)|Breast(359;0.00354)|Myeloproliferative disorder(1001;0.0122)		BRCA - Breast invasive adenocarcinoma(302;0.0025)		CCGGCTCACCGAAGAAGGGCG	0.692000													5	8					0	0	1	0	0
CRYBB1	1414	broad.mit.edu	37	22	26997881	26997881	+	Silent	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr22:26997881G>A	ENST00000215939.2	-	5	667	c.537C>T	c.(535-537)ttC>ttT	p.F179F		NM_001887.3	NP_001878.1	P53674	CRBB1_HUMAN	crystallin, beta B1	179	Beta/gamma crystallin 'Greek key' 3.				visual perception		structural constituent of eye lens			breast(1)|endometrium(4)|large_intestine(8)|lung(8)|ovary(1)|prostate(3)|skin(2)|urinary_tract(4)	31						CGCGGTCACTGAAGCCGTAGA	0.597000													11	28					0	0	1	0	0
DIAPH2	1730	broad.mit.edu	37	X	96167542	96167542	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chrX:96167542G>A	ENST00000324765.8	+	7	1070	c.723G>A	c.(721-723)atG>atA	p.M241I	DIAPH2_ENST00000373061.3_Missense_Mutation_p.M241I|DIAPH2_ENST00000355827.4_Missense_Mutation_p.M241I|DIAPH2_ENST00000373054.4_Missense_Mutation_p.M237I|DIAPH2_ENST00000373049.4_Missense_Mutation_p.M241I			O60879	DIAP2_HUMAN	diaphanous-related formin 2	241	GBD/FH3.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51						AAGCATTTATGAATAATAAGG	0.284000													14	8					0	0	1	0	0
RNASEH2B	79621	broad.mit.edu	37	13	51519637	51519637	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr13:51519637C>G	ENST00000336617.3	+	7	984	c.585C>G	c.(583-585)ttC>ttG	p.F195L	RNASEH2B_ENST00000495244.2_3'UTR|RNASEH2B_ENST00000422660.1_Missense_Mutation_p.F195L	NM_024570.3	NP_078846.2	Q5TBB1	RNH2B_HUMAN	ribonuclease H2, subunit B	195					RNA catabolic process	nucleus|ribonuclease H2 complex				endometrium(2)|liver(1)|lung(1)|upper_aerodigestive_tract(1)	5		Acute lymphoblastic leukemia(7;1.03e-07)|Breast(56;0.00122)|Lung NSC(96;0.00143)|Prostate(109;0.0047)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;9e-08)		CTGCATTTTTCTCTGGTGACC	0.393000													15	45					0	0	1	0	0
FAP	2191	broad.mit.edu	37	2	163075645	163075645	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr2:163075645G>A	ENST00000188790.4	-	8	742	c.535C>T	c.(535-537)Cca>Tca	p.P179S	FAP_ENST00000443424.1_Missense_Mutation_p.P154S	NM_004460.2	NP_004451.2	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha	179					endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(34)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)	63						TGAAAAGGTGGATCTCCTGGT	0.328000													27	39					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152192079	152192079	+	Missense_Mutation	SNP	C	C	T	rs141565920		TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr1:152192079C>T	ENST00000368801.2	-	3	2101	c.2026G>A	c.(2026-2028)Ggc>Agc	p.G676S	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	676					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCATGTTGGCCGTAGCTGGAA	0.587000													107	155					0	0	1	0	0
MFSD6	54842	broad.mit.edu	37	2	191301091	191301091	+	Silent	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr2:191301091C>T	ENST00000392328.1	+	3	660	c.336C>T	c.(334-336)ttC>ttT	p.F112F	MFSD6_ENST00000281416.7_Silent_p.F112F	NM_017694.3	NP_060164.3	Q6ZSS7	MFSD6_HUMAN	major facilitator superfamily domain containing 6	112					transmembrane transport	integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(3)|stomach(1)	23						TTCGTTACTTCATTGAATTCT	0.438000													5	93					0	0	1	0	0
RPS6KA6	27330	broad.mit.edu	37	X	83361948	83361948	+	Silent	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chrX:83361948G>A	ENST00000262752.2	-	14	1219	c.1212C>T	c.(1210-1212)atC>atT	p.I404I	RPS6KA6_ENST00000543399.1_Silent_p.I404I	NM_014496.4	NP_055311.1	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 6	404					axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(26)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	46						TTGCACTTGTGATAGGAGTGA	0.348000													9	7					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9923342	9923342	+	Silent	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr16:9923342G>A	ENST00000396573.2	-	10	2254	c.1945C>T	c.(1945-1947)Ctg>Ttg	p.L649L	GRIN2A_ENST00000404927.2_Silent_p.L649L|GRIN2A_ENST00000396575.2_Silent_p.L649L|GRIN2A_ENST00000562109.1_Silent_p.L649L|GRIN2A_ENST00000330684.3_Silent_p.L649L|GRIN2A_ENST00000535259.1_Silent_p.L492L	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	649					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AAGGCAGCCAGATTGGCTGTG	0.512000													60	56					0	0	1	0	0
TRIP6	7205	broad.mit.edu	37	7	100468338	100468338	+	Silent	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr7:100468338G>A	ENST00000200457.4	+	6	1332	c.972G>A	c.(970-972)agG>agA	p.R324R		NM_003302.2	NP_003293.2	Q15654	TRIP6_HUMAN	thyroid hormone receptor interactor 6	324					focal adhesion assembly|positive regulation of cell migration|regulation of transcription, DNA-dependent|release of cytoplasmic sequestered NF-kappaB|transcription, DNA-dependent	cytoplasm|cytoskeleton|focal adhesion|nucleus	identical protein binding|interleukin-1 receptor binding|kinase binding|thyroid hormone receptor binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|liver(1)|lung(5)	14	Lung NSC(181;0.041)|all_lung(186;0.0581)					CCGTGGAGAGGAGGGCATATT	0.607000													10	24					0	0	1	0	0
IRAK1BP1	134728	broad.mit.edu	37	6	79607666	79607666	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr6:79607666G>A	ENST00000369940.2	+	3	607	c.502G>A	c.(502-504)Gag>Aag	p.E168K	IRAK1BP1_ENST00000607739.1_Missense_Mutation_p.E81K	NM_001010844.2	NP_001010844.1	Q5VVH5	IKBP1_HUMAN	interleukin-1 receptor-associated kinase 1 binding protein 1	168					I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(3)	12		all_cancers(76;0.0398)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)		BRCA - Breast invasive adenocarcinoma(397;0.21)		AGGTTCTGTTGAGAATCTTCG	0.338000													20	55					0	0	1	0	0
DISP2	85455	broad.mit.edu	37	15	40657451	40657451	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr15:40657451G>C	ENST00000267889.3	+	6	910	c.823G>C	c.(823-825)Gag>Cag	p.E275Q		NM_033510.1	NP_277045.1	A7MBM2	DISP2_HUMAN	dispatched homolog 2 (Drosophila)	275					smoothened signaling pathway	integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)	30		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		CAGAAGGCAAGAGAACTTCTT	0.617000													11	31					0	0	1	0	0
GFRAL	389400	broad.mit.edu	37	6	55216139	55216139	+	Missense_Mutation	SNP	A	A	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr6:55216139A>C	ENST00000340465.2	+	5	545	c.459A>C	c.(457-459)aaA>aaC	p.K153N		NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like	153						integral to membrane	receptor activity			NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CTTACCTTAAAGCTTGCTCAG	0.453000													41	99					0	0	1	0	0
EXOC4	60412	broad.mit.edu	37	7	133059751	133059751	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr7:133059751C>G	ENST00000253861.4	+	7	1206	c.1177C>G	c.(1177-1179)Cta>Gta	p.L393V	EXOC4_ENST00000393161.2_Missense_Mutation_p.L393V|EXOC4_ENST00000539845.1_Missense_Mutation_p.L292V	NM_021807.3	NP_068579.3	Q96A65	EXOC4_HUMAN	exocyst complex component 4	393					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(16)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	50		Esophageal squamous(399;0.129)				CCAAGATGTTCTACAGGTAAG	0.418000													16	28					0	0	1	0	0
PHLDA3	23612	broad.mit.edu	37	1	201437628	201437628	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr1:201437628G>C	ENST00000367311.3	-	1	684	c.287C>G	c.(286-288)gCc>gGc	p.A96G	PHLDA3_ENST00000367309.1_Missense_Mutation_p.A96G|PHLDA3_ENST00000485436.1_5'UTR	NM_012396.3	NP_036528.1	Q9Y5J5	PHLA3_HUMAN	pleckstrin homology-like domain, family A, member 3	96	PH.				anatomical structure morphogenesis|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of protein kinase B signaling cascade	cytoplasm|intracellular membrane-bounded organelle|plasma membrane	identical protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding			lung(1)|prostate(1)	2						GGTGATCTGGGCGTTCCAGCC	0.657000													48	73					0	0	1	0	0
CDKN1A	1026	broad.mit.edu	37	6	36651906	36651906	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr6:36651906C>T	ENST00000405375.1	+	2	263	c.28C>T	c.(28-30)Cag>Tag	p.Q10*	CDKN1A_ENST00000373711.2_Nonsense_Mutation_p.Q10*|CDKN1A_ENST00000244741.5_Nonsense_Mutation_p.Q10*|CDKN1A_ENST00000448526.2_Nonsense_Mutation_p.Q44*|CDKN1A_ENST00000478800.1_3'UTR	NM_001220778.1	NP_001207707.1	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	10					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|urinary_tract(5)	15						GGATGTCCGTCAGAACCCATG	0.637000													6	23					0	0	1	0	0
PHLDB1	23187	broad.mit.edu	37	11	118526323	118526323	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr11:118526323G>A	ENST00000361417.2	+	22	4294	c.3883G>A	c.(3883-3885)Gag>Aag	p.E1295K	PHLDB1_ENST00000534672.1_3'UTR|PHLDB1_ENST00000527898.1_Missense_Mutation_p.E346K|PHLDB1_ENST00000356063.5_Missense_Mutation_p.E1248K|PHLDB1_ENST00000524713.1_Missense_Mutation_p.E438K	NM_015157.3	NP_055972.1	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B, member 1	1295	PH.									breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(10)|liver(3)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(1)	46	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		AGACAAGCATGAGACGAAGCT	0.547000													4	61					0	0	1	0	0
TRPC4AP	26133	broad.mit.edu	37	20	33637720	33637720	+	Silent	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr20:33637720C>T	ENST00000252015.2	-	6	695	c.606G>A	c.(604-606)aaG>aaA	p.K202K	TRPC4AP_ENST00000432634.2_Silent_p.K163K|TRPC4AP_ENST00000451813.2_Silent_p.K202K			Q8TEL6	TP4AP_HUMAN	transient receptor potential cation channel, subfamily C, member 4 associated protein	202	Interaction with TNFRSF1A (By similarity).				protein ubiquitination|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	protein binding			breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|skin(1)|stomach(1)|urinary_tract(1)	32			BRCA - Breast invasive adenocarcinoma(18;0.00936)			GTAAGAATGTCTTCTTACTTG	0.423000													27	51					0	0	1	0	0
SPTAN1	6709	broad.mit.edu	37	9	131339475	131339475	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr9:131339475C>T	ENST00000372739.3	+	7	963	c.853C>T	c.(853-855)Cga>Tga	p.R285*	SPTAN1_ENST00000372731.4_Nonsense_Mutation_p.R285*|SPTAN1_ENST00000358161.5_Nonsense_Mutation_p.R285*	NM_001130438.2	NP_001123910.1	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	285					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						TGATTTTGGCCGAGACCTGGC	0.483000													47	37					0	0	1	0	0
LIFR	3977	broad.mit.edu	37	5	38481878	38481878	+	Missense_Mutation	SNP	T	T	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr5:38481878T>G	ENST00000263409.4	-	20	3275	c.3113A>C	c.(3112-3114)aAt>aCt	p.N1038T	LIFR_ENST00000453190.2_Missense_Mutation_p.N1038T	NM_002310.5	NP_002301.1	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor alpha	1038					positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			NS(2)|breast(4)|endometrium(6)|kidney(2)|large_intestine(30)|liver(2)|lung(21)|ovary(3)|skin(5)|stomach(1)|urinary_tract(2)	78	all_lung(31;0.00021)					AGACACTAAATTCCATGTATT	0.418000			T	PLAG1	salivary adenoma								5	64					0	0	1	0	0
CPA3	1359	broad.mit.edu	37	3	148614342	148614342	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr3:148614342G>A	ENST00000296046.3	+	11	1154	c.1102G>A	c.(1102-1104)Gac>Aac	p.D368N	RP11-680B3.2_ENST00000488190.1_RNA	NM_001870.2	NP_001861.2	P15088	CBPA3_HUMAN	carboxypeptidase A3 (mast cell)	368					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			CTGGGCTTATGACCTGGGCAT	0.393000													43	60					0	0	1	0	0
RREB1	6239	broad.mit.edu	37	6	7229536	7229536	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr6:7229536C>T	ENST00000379938.2	+	10	1741	c.1204C>T	c.(1204-1206)Cag>Tag	p.Q402*	RREB1_ENST00000349384.6_Nonsense_Mutation_p.Q402*|RREB1_ENST00000379933.3_Nonsense_Mutation_p.Q402*|RREB1_ENST00000334984.6_Nonsense_Mutation_p.Q402*	NM_001003699.3|NM_001003700.1	NP_001003699.1|NP_001003700.1	Q92766	RREB1_HUMAN	ras responsive element binding protein 1	402					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(18)|ovary(5)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				TCAGCTACCTCAGGACCCCGG	0.607000													7	15					0	0	1	0	0
TMTC2	160335	broad.mit.edu	37	12	83290148	83290148	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr12:83290148C>G	ENST00000549919.1	+	4	2993	c.1188C>G	c.(1186-1188)atC>atG	p.I396M	TMTC2_ENST00000321196.3_Missense_Mutation_p.I402M|TMTC2_ENST00000548305.1_Missense_Mutation_p.I402M			Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat containing 2	402						endoplasmic reticulum|integral to membrane	binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(7)|lung(13)|ovary(2)|skin(1)|urinary_tract(1)	39						CTTTGTTAATCATACCCTTTG	0.388000													38	80					0	0	1	0	0
SPECC1	92521	broad.mit.edu	37	17	20108131	20108131	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr17:20108131C>T	ENST00000395530.2	+	2	734	c.526C>T	c.(526-528)Ctt>Ttt	p.L176F	AC004702.2_ENST00000580225.1_lincRNA|SPECC1_ENST00000472876.1_Intron|SPECC1_ENST00000261503.5_Missense_Mutation_p.L257F|SPECC1_ENST00000395525.3_Missense_Mutation_p.L176F|SPECC1_ENST00000395529.3_Missense_Mutation_p.L257F|SPECC1_ENST00000536879.1_Intron|SPECC1_ENST00000395527.4_Missense_Mutation_p.L257F|SPECC1_ENST00000395522.2_Missense_Mutation_p.L176F	NM_001033555.2	NP_001028727.1	Q5M775	CYTSB_HUMAN	sperm antigen with calponin homology and coiled-coil domains 1	257						nucleus				breast(1)|large_intestine(3)|ovary(4)	8				KIRC - Kidney renal clear cell carcinoma(2;0.166)|Kidney(2;0.196)		ACTGATCTATCTTGAGCACTC	0.483000													33	79					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170019075	170019075	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr2:170019075C>T	ENST00000263816.3	-	63	12079	c.11794G>A	c.(11794-11796)Gaa>Aaa	p.E3932K		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3932	LDL-receptor class A 36.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CACTTATATTCATATTCTGTA	0.388000													47	44					0	0	1	0	0
RBM27	54439	broad.mit.edu	37	5	145651076	145651076	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr5:145651076C>T	ENST00000265271.5	+	19	2993	c.2827C>T	c.(2827-2829)Cga>Tga	p.R943*	RBM27_ENST00000506502.1_Nonsense_Mutation_p.R888*	NM_018989.1	NP_061862.1	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27	943					mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(3)|endometrium(4)|kidney(5)|large_intestine(7)|liver(2)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACCTGTGGGTCGAGGAAAGAC	0.453000													15	24					0	0	1	0	0
CCDC178	374864	broad.mit.edu	37	18	30950114	30950114	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr18:30950114C>G	ENST00000383096.3	-	6	430	c.248G>C	c.(247-249)cGt>cCt	p.R83P	CCDC178_ENST00000406524.2_Missense_Mutation_p.R83P|CCDC178_ENST00000403303.1_Missense_Mutation_p.R83P|CCDC178_ENST00000402325.1_Missense_Mutation_p.R83P|CCDC178_ENST00000579947.1_Missense_Mutation_p.R83P|CCDC178_ENST00000579916.1_Missense_Mutation_p.R83P|CCDC178_ENST00000300227.8_Missense_Mutation_p.R83P|CCDC178_ENST00000583930.1_Missense_Mutation_p.R83P					coiled-coil domain containing 178																		ACAGCTGTGACGTCGACATGG	0.373000													14	37					0	0	1	0	0
TMEM248	55069	broad.mit.edu	37	7	66418223	66418223	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr7:66418223C>T	ENST00000341567.4	+	6	1046	c.791C>T	c.(790-792)tCa>tTa	p.S264L		NM_017994.4	NP_060464.1			transmembrane protein 248																		GATGACCGTTCATTAATAAAT	0.378000													33	75					0	0	1	0	0
FAM208B	54906	broad.mit.edu	37	10	5789319	5789319	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr10:5789319C>G	ENST00000328090.5	+	15	4560	c.3935C>G	c.(3934-3936)tCa>tGa	p.S1312*		NM_017782.4	NP_060252	Q5VWN6	CJ018_HUMAN	family with sequence similarity 208, member B	1312																	GCCCCATTCTCAAATTTAGAA	0.443000													40	95					0	0	1	0	0
USP9Y	8287	broad.mit.edu	37	Y	14848137	14848137	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chrY:14848137G>A	ENST00000338981.3	+	9	1924	c.979G>A	c.(979-981)Gag>Aag	p.E327K	USP9Y_ENST00000426564.2_3'UTR	NM_004654.3	NP_004645.2	O00507	USP9Y_HUMAN	ubiquitin specific peptidase 9, Y-linked	327					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			kidney(1)|large_intestine(8)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						AGGACAAGATGAGACTATAAA	0.289000													12	2					0	0	1	0	0
C20orf195	79025	broad.mit.edu	37	20	62187952	62187952	+	Silent	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr20:62187952C>T	ENST00000370098.3	+	2	1028	c.936C>T	c.(934-936)ccC>ccT	p.P312P	C20orf195_ENST00000370097.1_Silent_p.P312P	NM_024059.2	NP_076964.1	Q9BVV2	CT195_HUMAN	chromosome 20 open reading frame 195	312										large_intestine(3)|lung(4)	7	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			TGGAGGGGCCCGCCCTCAGCC	0.498000													42	71					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94060057	94060057	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr14:94060057C>G	ENST00000553484.1	+	23	3218	c.3064C>G	c.(3064-3066)Cag>Gag	p.Q1022E	UNC79_ENST00000256339.4_Missense_Mutation_p.Q845E|UNC79_ENST00000555664.1_Missense_Mutation_p.Q1022E|UNC79_ENST00000393151.2_Missense_Mutation_p.Q1022E			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1022						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						CGAGTTCTCTCAGCTGTCTTC	0.478000													4	54					0	0	1	0	0
NGEF	25791	broad.mit.edu	37	2	233748753	233748753	+	Silent	SNP	G	G	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr2:233748753G>C	ENST00000264051.3	-	11	1817	c.1539C>G	c.(1537-1539)ctC>ctG	p.L513L	NGEF_ENST00000539537.1_Silent_p.L236L|NGEF_ENST00000373552.4_Silent_p.L421L	NM_019850.2	NP_062824.2	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	513	PH.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(4)|endometrium(8)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|skin(4)	35		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		TTTCGTGGAAGAGCTTCTTGG	0.622000													3	15					0	0	1	0	0
VWA8	23078	broad.mit.edu	37	13	42442563	42442563	+	Silent	SNP	T	T	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr13:42442563T>C	ENST00000379310.3	-	10	1199	c.1131A>G	c.(1129-1131)gtA>gtG	p.V377V	VWA8_ENST00000281496.6_Silent_p.V377V	NM_015058.1	NP_055873.1			von Willebrand factor A domain containing 8																		TCTCTACTTTTACAATCTCTT	0.353000													23	36					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227895264	227895264	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr2:227895264C>T	ENST00000396625.3	-	41	4075	c.3868G>A	c.(3868-3870)Gag>Aag	p.E1290K	COL4A4_ENST00000329662.7_Missense_Mutation_p.E1290K	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1290	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TCACCTGGCTCCCCTCTCAGA	0.557000													6	44					0	0	1	0	0
ENO3	2027	broad.mit.edu	37	17	4858805	4858805	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr17:4858805C>A	ENST00000323997.6	+	8	903	c.771C>A	c.(769-771)taC>taA	p.Y257*	ENO3_ENST00000518175.1_Nonsense_Mutation_p.Y257*|ENO3_ENST00000519584.1_Nonsense_Mutation_p.Y214*	NM_001976.4|NM_053013.3	NP_001967.3|NP_443739.3	P13929	ENOB_HUMAN	enolase 3 (beta, muscle)	257					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex	magnesium ion binding|phosphopyruvate hydratase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)	15						ATGGGAAGTACGATCTTGACT	0.537000													12	227					7.03913e-09	7.44719e-09	1	1	0
FGFR3	2261	broad.mit.edu	37	4	1803568	1803568	+	Missense_Mutation	SNP	C	C	G	rs121913483		TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr4:1803568C>G	ENST00000340107.4	+	7	1002	c.746C>G	c.(745-747)tCc>tGc	p.S249C	FGFR3_ENST00000474521.1_3'UTR|FGFR3_ENST00000352904.1_Missense_Mutation_p.S249C|FGFR3_ENST00000260795.2_Missense_Mutation_p.S249C|FGFR3_ENST00000440486.2_Missense_Mutation_p.S249C|FGFR3_ENST00000412135.2_Missense_Mutation_p.S249C|FGFR3_ENST00000481110.2_Missense_Mutation_p.S249C	NM_001163213.1	NP_001156685.1	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3	249			S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1204)|p.R248_S249del(1)		NS(1)|central_nervous_system(5)|cervix(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(40)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(9)|skin(339)|soft_tissue(4)|testis(2)|upper_aerodigestive_tract(58)|urinary_tract(2607)	3091		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.736000		1	"""Mis, T"""	"""IGH@, ETV6"""	"""bladder, MM, T-cell lymphoma"""		"""Hypochondroplasia, Thanatophoric dysplasia"""		Saethre-Chotzen syndrome;Muenke syndrome				13	15					0	0	1	0	0
LRRC18	474354	broad.mit.edu	37	10	50121548	50121548	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr10:50121548C>T	ENST00000374160.3	-	1	729	c.653G>A	c.(652-654)cGg>cAg	p.R218Q	WDFY4_ENST00000325239.5_Intron|RP11-523O18.7_ENST00000430438.1_RNA|LRRC18_ENST00000298124.3_Missense_Mutation_p.R218Q|WDFY4_ENST00000413659.2_Intron	NM_001006939.3	NP_001006940.3	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	218						cytoplasm				NS(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	18						CAGGTTGTCCCGGGCGTTTTG	0.498000													20	61					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189873943	189873943	+	Silent	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr2:189873943G>A	ENST00000304636.3	+	48	3989	c.3819G>A	c.(3817-3819)aaG>aaA	p.K1273K	COL3A1_ENST00000317840.5_Silent_p.K970K	NM_000090.3	NP_000081	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	1273	Fibrillar collagen NC1.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CTGAACTCAAGAGTGGTATGT	0.398000													20	27					0	0	1	0	0
PRR12	57479	broad.mit.edu	37	19	50123664	50123664	+	Silent	SNP	G	G	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr19:50123664G>C	ENST00000418929.2	+	10	5565	c.5553G>C	c.(5551-5553)cgG>cgC	p.R1851R		NM_020719.1	NP_065770.1	Q9ULL5	PRR12_HUMAN	proline rich 12	1030							DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)|prostate(2)	11		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		AGATGTACCGGAGCTACGTGG	0.607000													2	4					0	0	1	0	0
LRRC16B	90668	broad.mit.edu	37	14	24535666	24535666	+	Silent	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr14:24535666C>T	ENST00000342740.5	+	35	3739	c.3585C>T	c.(3583-3585)gaC>gaT	p.D1195D	LRRC16B_ENST00000334420.7_Silent_p.D248D	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	1195										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		GCTCTTCAGACGACGCAGGTA	0.542000													25	53					0	0	1	0	0
DOPEY1	23033	broad.mit.edu	37	6	83841922	83841922	+	Silent	SNP	T	T	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr6:83841922T>C	ENST00000349129.2	+	18	2904	c.2644T>C	c.(2644-2646)Ttg>Ctg	p.L882L	DOPEY1_ENST00000369739.3_Silent_p.L873L|DOPEY1_ENST00000237163.5_Silent_p.L863L	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	882					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		GTGGGACCAGTTGGGAGATGG	0.353000													23	43					0	0	1	0	0
GPRASP2	114928	broad.mit.edu	37	X	101972243	101972243	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chrX:101972243G>C	ENST00000543253.1	+	5	3365	c.2446G>C	c.(2446-2448)Gag>Cag	p.E816Q	GPRASP2_ENST00000332262.5_Missense_Mutation_p.E816Q|GPRASP2_ENST00000535209.1_Missense_Mutation_p.E816Q	NM_001004051.3|NM_001184874.2|NM_001184876.2	NP_001004051.1|NP_001171803.1|NP_001171805.1			G protein-coupled receptor associated sorting protein 2											breast(3)|endometrium(5)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	30						TCGTGAATTTGAGGAGTTAGC	0.378000													5	69					0	0	1	0	0
SGSM2	9905	broad.mit.edu	37	17	2266166	2266166	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr17:2266166C>A	ENST00000268989.3	+	5	670	c.493C>A	c.(493-495)Cct>Act	p.P165T	SGSM2_ENST00000574563.1_Missense_Mutation_p.P165T|SGSM2_ENST00000426855.2_Missense_Mutation_p.P165T	NM_014853.2	NP_055668.2	O43147	SGSM2_HUMAN	small G protein signaling modulator 2	165	RUN.					intracellular	Rab GTPase activator activity			biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(2;5.15e-05)|READ - Rectum adenocarcinoma(2;0.000115)		GCTGGCAGACCCTGTGTTCGG	0.627000													18	40					6.49762e-13	7.0795e-13	1	1	0
PRRC2C	23215	broad.mit.edu	37	1	171556229	171556229	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr1:171556229C>T	ENST00000367742.3	+	31	8079	c.7837C>T	c.(7837-7839)Cag>Tag	p.Q2613*	PRRC2C_ENST00000426496.2_Nonsense_Mutation_p.Q2546*|PRRC2C_ENST00000338920.4_Nonsense_Mutation_p.Q2611*|PRRC2C_ENST00000392078.3_Nonsense_Mutation_p.Q2613*			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	2611	Gln-rich.						protein C-terminus binding										TCAGACTCTTCAGCCCCCATT	0.478000													3	16					0	0	1	0	0
NKX2-2	4821	broad.mit.edu	37	20	21492988	21492988	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr20:21492988C>G	ENST00000377142.4	-	2	751	c.395G>C	c.(394-396)cGa>cCa	p.R132P		NM_002509.3	NP_002500.1	O95096	NKX22_HUMAN	NK2 homeobox 2	132					brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21						GAAAAGCACTCGCCGCTTTCG	0.682000													5	17					0	0	1	0	0
AOX1	316	broad.mit.edu	37	2	201450847	201450847	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr2:201450847G>C	ENST00000374700.2	+	1	257	c.16G>C	c.(16-18)Gag>Cag	p.E6Q		NM_001159.3	NP_001150.3	Q06278	ADO_HUMAN	aldehyde oxidase 1	6	2Fe-2S ferredoxin-type.				inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			breast(5)|endometrium(3)|kidney(4)|large_intestine(13)|lung(38)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	81					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	CCGGGCGTCCGAGCTGCTCTT	0.726000													3	1					0	0	1	0	0
CCDC17	149483	broad.mit.edu	37	1	46088753	46088753	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr1:46088753C>T	ENST00000421127.2	-	4	646	c.503G>A	c.(502-504)cGg>cAg	p.R168Q	CCDC17_ENST00000528266.1_Missense_Mutation_p.R177Q|CCDC17_ENST00000445048.2_Intron|CCDC17_ENST00000343901.2_Missense_Mutation_p.R145Q	NM_001114938.2|NM_001190182.1	NP_001108410.2|NP_001177111.1	Q96LX7	CCD17_HUMAN	coiled-coil domain containing 17	177										kidney(1)|large_intestine(1)|lung(1)|ovary(2)	5	Acute lymphoblastic leukemia(166;0.155)					CATCCCGCCCCGCGTACAGGC	0.657000													6	11					0	0	1	0	0
VWA5A	4013	broad.mit.edu	37	11	124006841	124006841	+	Silent	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr11:124006841C>T	ENST00000456829.2	+	13	1616	c.1365C>T	c.(1363-1365)ctC>ctT	p.L455L	VWA5A_ENST00000360334.4_Intron|VWA5A_ENST00000392748.1_Silent_p.L455L	NM_001130142.1	NP_001123614.1	O00534	VMA5A_HUMAN	von Willebrand factor A domain containing 5A	455	VWFA.									autonomic_ganglia(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(17)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	47						ATTAGGCTCTCAGGACTCTGA	0.438000													56	88					0	0	1	0	0
FSIP2	401024	broad.mit.edu	37	2	186672259	186672259	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr2:186672259G>A	ENST00000343098.5	+	17	18493	c.18493G>A	c.(18493-18495)Gat>Aat	p.D6165N	FSIP2_ENST00000424728.1_Missense_Mutation_p.D6076N	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						CTTACAATCTGATGATGATGA	0.328000													33	97					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52588011	52588011	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr10:52588011C>G	ENST00000374001.2	-	6	788	c.649G>C	c.(649-651)Gag>Cag	p.E217Q	A1CF_ENST00000493415.1_5'UTR|A1CF_ENST00000282641.2_Missense_Mutation_p.E217Q|A1CF_ENST00000395495.1_Intron|A1CF_ENST00000373997.3_Missense_Mutation_p.E217Q|A1CF_ENST00000373995.3_Missense_Mutation_p.E225Q|A1CF_ENST00000395489.2_Missense_Mutation_p.E210Q|A1CF_ENST00000373993.1_Missense_Mutation_p.E217Q			Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor		RRM 2.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						ACTTCTGGCTCTGCCCAGTCT	0.368000													4	96					0	0	1	0	0
C14orf166B	145497	broad.mit.edu	37	14	77319640	77319640	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr14:77319640C>T	ENST00000393774.3	+	9	1019	c.895C>T	c.(895-897)Cga>Tga	p.R299*	C14orf166B_ENST00000450042.2_3'UTR	NM_194287.2	NP_919263.2	Q0VAA2	CN16B_HUMAN	chromosome 14 open reading frame 166B	299										breast(1)|kidney(2)|large_intestine(3)|lung(9)|prostate(2)|skin(1)	18			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0306)		GGAAGTCCTCCGACTCAACCG	0.537000													28	38					0	0	1	0	0
IL37	27178	broad.mit.edu	37	2	113676300	113676300	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr2:113676300G>T	ENST00000263326.3	+	5	613	c.571G>T	c.(571-573)Gat>Tat	p.D191Y	IL37_ENST00000352179.3_Missense_Mutation_p.D170Y|IL37_ENST00000349806.3_Missense_Mutation_p.D130Y|IL37_ENST00000353225.3_Missense_Mutation_p.D151Y|IL37_ENST00000311328.2_Missense_Mutation_p.D165Y	NM_014439.3	NP_055254.2	Q9NZH6	IL37_HUMAN	interleukin 37	191					immune response	cytosol|extracellular space|nucleus	cytokine activity|interleukin-1 receptor antagonist activity|interleukin-1 receptor binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(1)|lung(7)|ovary(2)|skin(3)	19						TGGGGTGACAGATAAATTTGA	0.498000													15	31					1.05317e-09	1.11963e-09	1	1	0
GTF2B	2959	broad.mit.edu	37	1	89323155	89323155	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr1:89323155G>T	ENST00000370500.5	-	6	669	c.551C>A	c.(550-552)tCa>tAa	p.S184*	GTF2B_ENST00000494819.1_5'UTR	NM_001514.5	NP_001505.1	Q00403	TF2B_HUMAN	general transcription factor IIB	184					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	thyroid hormone receptor binding|translation initiation factor activity|zinc ion binding			endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10		Lung NSC(277;0.123)		all cancers(265;0.0131)|Epithelial(280;0.0255)		AGAAATTCGTGATACGGCACA	0.299000													31	45					1.55811e-20	1.7147e-20	1	1	0
SPNS1	83985	broad.mit.edu	37	16	28994238	28994238	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr16:28994238C>A	ENST00000311008.11	+	9	1593	c.1216C>A	c.(1216-1218)Ctg>Atg	p.L406M	SPNS1_ENST00000352260.7_Missense_Mutation_p.L332M|SPNS1_ENST00000334536.8_Missense_Mutation_p.L354M|SPNS1_ENST00000323081.8_Missense_Mutation_p.L333M|RP11-264B17.3_ENST00000569969.1_RNA|SPNS1_ENST00000565975.1_Missense_Mutation_p.L451M	NM_032038.2	NP_114427.1	Q9H2V7	SPNS1_HUMAN	spinster homolog 1 (Drosophila)	406					lipid transport|transmembrane transport	integral to membrane|mitochondrial inner membrane	protein binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)|urinary_tract(1)	21						GGCCGACATTCTGCTGGTGAG	0.582000													28	41					1.17739e-12	1.27648e-12	1	1	0
NCKAP5	344148	broad.mit.edu	37	2	133542664	133542664	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr2:133542664C>T	ENST00000409261.1	-	14	2093	c.1720G>A	c.(1720-1722)Gct>Act	p.A574T	NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Missense_Mutation_p.A574T	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	574							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						AGGTTGAGAGCCATGCGGCCA	0.552000													4	91					0	0	1	0	0
ETNPPL	64850	broad.mit.edu	37	4	109669170	109669170	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr4:109669170C>T	ENST00000296486.3	-	9	1227	c.1073G>A	c.(1072-1074)gGa>gAa	p.G358E	ETNPPL_ENST00000411864.2_Missense_Mutation_p.G352E|ETNPPL_ENST00000510706.1_Missense_Mutation_p.G318E|ETNPPL_ENST00000512646.1_Missense_Mutation_p.G300E	NM_001146590.1|NM_031279.3	NP_001140062.1|NP_112569.2			ethanolamine-phosphate phospho-lyase									p.G358V(1)									CCTAATATCTCCTATCAAAGT	0.348000													3	43					0	0	1	0	0
NFKBIZ	64332	broad.mit.edu	37	3	101578176	101578176	+	Silent	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr3:101578176G>A	ENST00000326172.5	+	12	2233	c.2118G>A	c.(2116-2118)ctG>ctA	p.L706L	NFKBIZ_ENST00000394054.2_Silent_p.L606L|NFKBIZ_ENST00000326151.5_Silent_p.L584L	NM_031419.3	NP_113607.1	Q9BYH8	IKBZ_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	706	Interaction with NFKB1/p50 (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24						GACGTATCCTGAAGGGAAAGT	0.428000													6	26					0	0	1	0	0
SLC35B2	347734	broad.mit.edu	37	6	44223148	44223148	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr6:44223148C>T	ENST00000393812.3	-	4	737	c.594G>A	c.(592-594)tgG>tgA	p.W198*	SLC35B2_ENST00000537814.1_Nonsense_Mutation_p.W65*|SLC35B2_ENST00000393810.1_3'UTR|SLC35B2_ENST00000495706.1_5'UTR|SLC35B2_ENST00000538577.1_Nonsense_Mutation_p.W105*	NM_178148.2	NP_835361.1	Q8TB61	S35B2_HUMAN	solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2	198					positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity|signal transducer activity			breast(1)|central_nervous_system(2)|kidney(3)|large_intestine(2)|lung(4)|ovary(2)|urinary_tract(1)	15	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CGTATTGGCACCAGCTGCTAA	0.572000													44	61					0	0	1	0	0
FAM177A1	283635	broad.mit.edu	37	14	35546420	35546420	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr14:35546420C>A	ENST00000396472.1	+	5	794	c.335C>A	c.(334-336)tCa>tAa	p.S112*	FAM177A1_ENST00000280987.4_Nonsense_Mutation_p.S135*|FAM177A1_ENST00000382406.3_Nonsense_Mutation_p.S112*	NM_001079519.1	NP_001072987.1	Q8N128	F177A_HUMAN	family with sequence similarity 177, member A1	112										breast(1)|large_intestine(1)|lung(2)|urinary_tract(1)	5						TCAACTCTCTCAGGTATTGCT	0.388000													56	115					1.74971e-23	1.94511e-23	1	1	0
BZRAP1	9256	broad.mit.edu	37	17	56389782	56389782	+	Silent	SNP	G	G	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr17:56389782G>C	ENST00000355701.3	-	17	3270	c.2400C>G	c.(2398-2400)ctC>ctG	p.L800L	BZRAP1_ENST00000268893.6_Silent_p.L740L|BZRAP1_ENST00000343736.4_Silent_p.L800L	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	800	Fibronectin type-III 1.					mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCAGCTGCTTGAGGACCACCA	0.662000													10	19					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	107937752	107937752	+	Silent	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr12:107937752C>G	ENST00000280758.5	+	3	1854	c.1326C>G	c.(1324-1326)ctC>ctG	p.L442L	BTBD11_ENST00000420571.2_Silent_p.L442L|BTBD11_ENST00000490090.2_Silent_p.L442L	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	442						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						TGCAGCCCCTCAATGCCAAGC	0.567000													11	10					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21230763	21230763	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr2:21230763C>G	ENST00000233242.1	-	26	9104	c.8977G>C	c.(8977-8979)Gat>Cat	p.D2993H		NM_000384.2	NP_000375	P04114	APOB_HUMAN	apolipoprotein B	2993					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGCTGGGAATCGACTTGTGAT	0.418000													19	41					0	0	1	0	0
VPS13A	23230	broad.mit.edu	37	9	80020847	80020847	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr9:80020847G>A	ENST00000360280.3	+	70	9603	c.9343G>A	c.(9343-9345)Gaa>Aaa	p.E3115K	VPS13A_ENST00000376646.3_Missense_Mutation_p.E51K|VPS13A_ENST00000376636.3_Missense_Mutation_p.E3076K|VPS13A_ENST00000484581.2_Missense_Mutation_p.E51K	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)	3115					Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						TAGTTTTGATGAATTTACCAA	0.338000													29	24					0	0	1	0	0
NOL3	8996	broad.mit.edu	37	16	67208956	67208956	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr16:67208956G>A	ENST00000568146.1	+	4	669	c.616G>A	c.(616-618)Gaa>Aaa	p.E206K	NOL3_ENST00000564053.1_Silent_p.*271*|NOL3_ENST00000268605.7_Silent_p.*209*|NOL3_ENST00000432069.2_Silent_p.*209*			O60936	NOL3_HUMAN	nucleolar protein 3 (apoptosis repressor with CARD domain)	206					anti-apoptosis|apoptosis|mRNA processing|RNA splicing	cytosol|nucleolus	identical protein binding|RNA binding			ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		CTAGATTCCTGAAGGCCAGAG	0.647000													4	129					0	0	1	0	0
CEP192	55125	broad.mit.edu	37	18	13072797	13072797	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr18:13072797C>G	ENST00000506447.1	+	29	5472	c.5392C>G	c.(5392-5394)Caa>Gaa	p.Q1798E	CEP192_ENST00000325971.8_Missense_Mutation_p.Q1202E|CEP192_ENST00000430049.2_Missense_Mutation_p.Q1323E	NM_032142.3	NP_115518.3	B7ZMF0	B7ZMF0_HUMAN	centrosomal protein 192kDa	1393										NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(36)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						ATCTACAACTCAACATTTACG	0.363000													22	52					0	0	1	0	0
NUP205	23165	broad.mit.edu	37	7	135304280	135304280	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr7:135304280C>T	ENST00000285968.6	+	29	4099	c.4073C>T	c.(4072-4074)tCa>tTa	p.S1358L		NM_015135.2	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1358					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						AAGGAAACATCAGTCTTGGGA	0.512000													15	38					0	0	1	0	0
NMI	9111	broad.mit.edu	37	2	152132312	152132312	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr2:152132312G>A	ENST00000243346.5	-	5	877	c.407C>T	c.(406-408)aCg>aTg	p.T136M		NM_004688.2	NP_004679.2	Q13287	NMI_HUMAN	N-myc (and STAT) interactor	136					inflammatory response|JAK-STAT cascade|transcription from RNA polymerase II promoter	cytoplasm|nucleus	nucleotide binding|protein binding|transcription cofactor activity			endometrium(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	11				BRCA - Breast invasive adenocarcinoma(221;0.0571)		TGGCTTGGCCGTAACCTCCAG	0.353000													3	53					0	0	1	0	0
LIG4	3981	broad.mit.edu	37	13	108861580	108861580	+	Silent	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr13:108861580C>T	ENST00000356922.4	-	2	2309	c.2037G>A	c.(2035-2037)gaG>gaA	p.E679E	LIG4_ENST00000442234.1_Silent_p.E679E|LIG4_ENST00000405925.1_Silent_p.E679E	NM_002312.3|NM_206937.1	NP_002303.2|NP_996820.1	P49917	DNLI4_HUMAN	ligase IV, DNA, ATP-dependent	679	BRCT 1.				cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					CAATTCTGTTCTCCAGGTCAG	0.383000								Non-homologous end-joining					26	47					0	0	1	0	0
KDM3A	55818	broad.mit.edu	37	2	86705339	86705339	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr2:86705339G>C	ENST00000409556.1	+	15	2504	c.2139G>C	c.(2137-2139)caG>caC	p.Q713H	KDM3A_ENST00000542128.1_Missense_Mutation_p.Q661H|KDM3A_ENST00000312912.5_Missense_Mutation_p.Q713H|KDM3A_ENST00000409064.1_Missense_Mutation_p.Q713H			Q9Y4C1	KDM3A_HUMAN	lysine (K)-specific demethylase 3A	713					androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(3)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|liver(1)|lung(13)|ovary(1)|prostate(3)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	47						TGAAGAGTCAGATACATGAAC	0.403000													3	61					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228495952	228495952	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr1:228495952G>A	ENST00000570156.2	+	58	15552	c.15478G>A	c.(15478-15480)Gag>Aag	p.E5160K	OBSCN_ENST00000366709.4_Missense_Mutation_p.E1322K|OBSCN_ENST00000366707.4_Missense_Mutation_p.E1837K|OBSCN_ENST00000422127.1_Missense_Mutation_p.E4203K|OBSCN_ENST00000284548.11_Missense_Mutation_p.E4203K	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	4203	Ig-like 49.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GCAAAGCAATGAGGTGACAGA	0.627000													18	31					0	0	1	0	0
S100A7L2	645922	broad.mit.edu	37	1	153410822	153410822	+	Splice_Site	SNP	C	C	A	rs10888561	by1000genomes	TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr1:153410822C>A	ENST00000368725.2	-	2	16	c.17G>T	c.(16-18)gGc>gTc	p.G6V		NM_001045479.1	NP_001038944.2			S100 calcium binding protein A7-like 2											NS(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	8	all_lung(78;2.4e-33)|Lung NSC(65;8.13e-32)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			TTTCAAAAAGCCTTCAGGAAA	0.408000													22	41					7.45023e-12	8.03743e-12	1	1	0
CSNK1D	1453	broad.mit.edu	37	17	80210471	80210471	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr17:80210471C>T	ENST00000314028.6	-	5	924	c.575G>A	c.(574-576)cGa>cAa	p.R192Q	CSNK1D_ENST00000392334.2_Missense_Mutation_p.R192Q|CSNK1D_ENST00000578904.1_5'UTR|CSNK1D_ENST00000398519.5_Missense_Mutation_p.R192Q	NM_001893.4	NP_001884.2	P48730	KC1D_HUMAN	casein kinase 1, delta	192	Protein kinase.				circadian regulation of gene expression|DNA repair|G2/M transition of mitotic cell cycle|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|regulation of circadian rhythm|Wnt receptor signaling pathway	centrosome|cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|large_intestine(2)|lung(7)	11	Breast(20;0.00136)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0155)			GTCATCTCTTCGGGATTGTTC	0.542000													8	32					0	0	1	0	0
IRX5	10265	broad.mit.edu	37	16	54966534	54966534	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr16:54966534C>T	ENST00000394636.4	+	2	711	c.374C>T	c.(373-375)aCg>aTg	p.T125M	IRX5_ENST00000558597.1_Missense_Mutation_p.T59M|IRX5_ENST00000320990.5_Missense_Mutation_p.T125M|IRX5_ENST00000560154.1_Intron			P78411	IRX5_HUMAN	iroquois homeobox 5	125					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding			kidney(3)|large_intestine(6)|lung(4)|prostate(1)	14						AGGGACGCCACGGCTACCCTC	0.637000													5	73					0	0	1	0	0
SEMA5B	54437	broad.mit.edu	37	3	122645406	122645406	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr3:122645406C>G	ENST00000195173.4	-	9	1272	c.969G>C	c.(967-969)aaG>aaC	p.K323N	SEMA5B_ENST00000451055.2_Missense_Mutation_p.K377N|SEMA5B_ENST00000357599.3_Missense_Mutation_p.K323N			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	323	Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		CCACGTCATTCTTGCACACGC	0.597000													5	15					0	0	1	0	0
WDR90	197335	broad.mit.edu	37	16	705107	705107	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr16:705107G>C	ENST00000549091.1	+	14	1608	c.1516G>C	c.(1516-1518)Gac>Cac	p.D506H	LA16c-349E10.1_ENST00000573609.1_RNA|WDR90_ENST00000293879.4_Missense_Mutation_p.D506H	NM_145294.4	NP_660337.3	Q96KV7	WDR90_HUMAN	WD repeat domain 90	506										endometrium(4)|kidney(3)|large_intestine(2)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	37		Hepatocellular(780;0.0218)				CACTGACTTTGACGTCCAGGC	0.647000													13	32					0	0	1	0	0
MUC7	4589	broad.mit.edu	37	4	71346978	71346978	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr4:71346978T>C	ENST00000413702.1	+	4	805	c.517T>C	c.(517-519)Tct>Cct	p.S173P	MUC7_ENST00000514512.1_3'UTR|MUC7_ENST00000456088.1_Missense_Mutation_p.S173P|MUC7_ENST00000304887.5_Missense_Mutation_p.S173P	NM_001145006.1	NP_001138478.1	Q8TAX7	MUC7_HUMAN	mucin 7, secreted	173	Thr-rich.					extracellular region	protein binding	p.S173P(3)		central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(2)|lung(23)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42			Lung(101;0.211)			ACCCACACCTTCTGCAACTAC	0.522000													4	90					0	0	1	0	0
APC	324	broad.mit.edu	37	5	112174588	112174588	+	Silent	SNP	T	T	G			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr5:112174588T>G	ENST00000457016.1	+	16	3677	c.3297T>G	c.(3295-3297)gtT>gtG	p.V1099V	CTC-554D6.1_ENST00000520401.1_Intron|APC_ENST00000508376.2_Silent_p.V1099V|APC_ENST00000257430.4_Silent_p.V1099V			P25054	APC_HUMAN	adenomatous polyposis coli	1099	Responsible for down-regulation through a process mediated by direct ubiquitination.|Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		AGGAATGTGTTTCTCCATACA	0.403000		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			20	52					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152324558	152324559	+	Frame_Shift_Del	DEL	TG	TG	-	rs140875805	byFrequency	TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr1:152324558_152324559delTG	ENST00000388718.5	-	3	5775_5776	c.5703_5704delCA	c.(5701-5706)cacagcfs	p.HS1901fs	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1901							calcium ion binding|structural molecule activity	p.H1901fs*30(1)		NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGGCTTGGCTGTGTGTGTGTC	0.515													8	342	---	---	---	---					
CAMLG	819	broad.mit.edu	37	5	134076756	134076759	+	Frame_Shift_Del	DEL	AAGA	AAGA	-			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr5:134076756_134076759delAAGA	ENST00000297156.2	+	2	296_299	c.176_179delAAGA	c.(175-180)gaagaafs	p.EE59fs	CAMLG_ENST00000514518.1_Intron	NM_001745.3	NP_001736.1	P49069	CAMLG_HUMAN	calcium modulating ligand	59					defense response	endoplasmic reticulum|integral to membrane				NS(1)|cervix(1)|kidney(3)|lung(3)|prostate(1)	9			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Cyclosporine(DB00091)	TTCTCAGAAGAAGAAAGTCAAACA	0.382													10	16	---	---	---	---					
CDKN1A	1026	broad.mit.edu	37	6	36652053	36652068	+	Frame_Shift_Del	DEL	CTGGAGGGTGACTTCG	CTGGAGGGTGACTTCG	-	rs4986867	byFrequency	TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr6:36652053_36652068delCTGGAGGGTGACTTCG	ENST00000405375.1	+	2	410_425	c.175_190delCTGGAGGGTGACTTCG	c.(175-192)ctggagggtgacttcgccfs	p.LEGDFA59fs	CDKN1A_ENST00000448526.2_Frame_Shift_Del_p.LEGDFA93fs|CDKN1A_ENST00000478800.1_3'UTR|CDKN1A_ENST00000373711.2_Frame_Shift_Del_p.LEGDFA59fs|CDKN1A_ENST00000244741.5_Frame_Shift_Del_p.LEGDFA59fs	NM_001220778.1	NP_001207707.1	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	59					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding	p.G61V(1)|p.A64fs*25(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|urinary_tract(5)	15						CGAGACACCACTGGAGGGTGACTTCGCCTGGGAGCG	0.676													9	32	---	---	---	---					
TSC1	7248	broad.mit.edu	37	9	135787750	135787751	+	Frame_Shift_Del	DEL	AC	AC	-	rs118203456		TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr9:135787750_135787751delAC	ENST00000298552.3	-	9	1052_1053	c.831_832delGT	c.(829-834)gtgtctfs	p.S278fs	TSC1_ENST00000545250.1_Frame_Shift_Del_p.S227fs|TSC1_ENST00000403810.1_Frame_Shift_Del_p.S278fs|TSC1_ENST00000440111.2_Frame_Shift_Del_p.S278fs	NM_000368.4|NM_001162426.1|NM_001162427.1	NP_000359.1|NP_001155898.1|NP_001155899.1	Q92574	TSC1_HUMAN	tuberous sclerosis 1	278					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		NS(1)|bone(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(9)|lung(20)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	65				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		ATTTGGTGAGACACAGAATAGC	0.450			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				11	16	---	---	---	---					
SOX5	6660	broad.mit.edu	37	12	23999053	23999053	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr12:23999053delT	ENST00000546136.1	-	2	308	c.306delA	c.(304-306)gaafs	p.E102fs	SOX5_ENST00000541847.1_Frame_Shift_Del_p.E105fs|SOX5_ENST00000541536.1_Frame_Shift_Del_p.E102fs|SOX5_ENST00000537393.1_Frame_Shift_Del_p.E80fs|SOX5_ENST00000309359.1_Frame_Shift_Del_p.E102fs|SOX5_ENST00000451604.2_Frame_Shift_Del_p.E115fs|SOX5_ENST00000545921.1_Frame_Shift_Del_p.E105fs|SOX5_ENST00000381381.2_Frame_Shift_Del_p.E102fs|SOX5_ENST00000441133.2_Frame_Shift_Del_p.E80fs			P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5	115					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(25)|ovary(5)|skin(2)|upper_aerodigestive_tract(3)	57						GTCGCCCACCTTCTTCTGCCT	0.478													31	41	---	---	---	---					
ARID2	196528	broad.mit.edu	37	12	46243452	46243452	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr12:46243452delG	ENST00000334344.6	+	14	1977	c.1805delG	c.(1804-1806)aggfs	p.R602fs	ARID2_ENST00000444670.1_Frame_Shift_Del_p.R212fs|ARID2_ENST00000422737.1_Frame_Shift_Del_p.R453fs|ARID2_ENST00000479608.1_3'UTR	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	602					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		GTAAAACGGAGGGCTATACCA	0.443			"""N, S, F"""		hepatocellular carcinoma								49	125	---	---	---	---					
LILRB5	10990	broad.mit.edu	37	19	54754838	54754839	+	Frame_Shift_Ins	INS	-	-	G	rs11375503		TCGA-CF-A9FF-01A-11D-A38G-08	TCGA-CF-A9FF-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3e957106-6640-40e8-b34f-d7be77ed8a3d	a26ae277-b5b8-4c1e-80c9-34e2ffee09b7	g.chr19:54754838_54754839insG	ENST00000450632.1	-	13	1873_1874	c.1796_1797insC	c.(1795-1797)ccafs	p.P599fs	LILRB5_ENST00000449561.2_Intron|LILRB5_ENST00000345866.6_Intron|LILRB5_ENST00000316219.5_Intron			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	424					cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GTGGTGGGGGTGGGGAGGCCTG	0.604													4	9	---	---	---	---					
