Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MST1L	11223	broad.mit.edu	37	1	17083621	17083621	+	RNA	SNP	A	A	G			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr1:17083621A>G	ENST00000455405.2	-	0	967																											ttggtgaagtagtaaaaatat	0.363000													3	27					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113558488	113558488	+	Silent	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr7:113558488G>A	ENST00000284601.3	-	1	632	c.564C>T	c.(562-564)ttC>ttT	p.F188F		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	188	CBM21.				glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TCTTAAAGGAGAACTGGTCAG	0.333000													31	45					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216243500	216243500	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr1:216243500G>A	ENST00000366943.2	-	30	6378	c.5992C>T	c.(5992-5994)Cgt>Tgt	p.R1998C	USH2A_ENST00000307340.3_Missense_Mutation_p.R1998C			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1998	Fibronectin type-III 6.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CGGGGTGGACGGGTGCTGTCC	0.458000										HNSCC(13;0.011)			20	39					0	0	1	0	0
TRIM46	80128	broad.mit.edu	37	1	155154441	155154441	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr1:155154441G>A	ENST00000368382.1	+	9	1770	c.1633G>A	c.(1633-1635)Gac>Aac	p.D545N	TRIM46_ENST00000545012.1_Missense_Mutation_p.D442N|TRIM46_ENST00000334634.4_Missense_Mutation_p.D568N|TRIM46_ENST00000468878.1_3'UTR|TRIM46_ENST00000543729.1_3'UTR|TRIM46_ENST00000392451.2_3'UTR|RP11-201K10.3_ENST00000473363.2_Intron|TRIM46_ENST00000368383.3_Missense_Mutation_p.D568N	NM_001256599.1|NM_001256600.1|NM_001256601.1|NM_025058.4	NP_001243528.1|NP_001243529.1|NP_001243530.1|NP_079334.3	Q7Z4K8	TRI46_HUMAN	tripartite motif containing 46	568	B30.2/SPRY.					intracellular	zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	29	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GCTggctgctgaccggctgct	0.687000													83	36					0	0	1	0	0
CDK18	5129	broad.mit.edu	37	1	205495908	205495908	+	Silent	SNP	T	T	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr1:205495908T>C	ENST00000360066.2	+	8	973	c.672T>C	c.(670-672)agT>agC	p.S224S	CDK18_ENST00000509056.1_3'UTR|CDK18_ENST00000429964.2_Silent_p.S224S|CDK18_ENST00000506784.1_Silent_p.S254S	NM_002596.3|NM_212502.2|NM_212503.2	NP_002587.2|NP_997667.1|NP_997668.1	Q07002	CDK18_HUMAN	cyclin-dependent kinase 18	222	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|protein binding|signal transducer activity			breast(2)|endometrium(2)|large_intestine(2)|lung(10)|stomach(2)|urinary_tract(1)	19						TCCAGGACAGTGACCTGAAGC	0.627000													8	143					0	0	1	0	0
THEG	51298	broad.mit.edu	37	19	367166	367166	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr19:367166A>G	ENST00000342640.4	-	7	854	c.812T>C	c.(811-813)tTg>tCg	p.L271S	THEG_ENST00000346878.2_Missense_Mutation_p.L247S	NM_016585.4	NP_057669.1	Q9P2T0	THEG_HUMAN	theg spermatid protein	271					cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)|soft_tissue(1)	29		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGCTTTGACAACTGGAGGAT	0.572000													28	215					0	0	1	0	0
KCNT1	57582	broad.mit.edu	37	9	138662244	138662244	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr9:138662244G>A	ENST00000298480.5	+	17	1794	c.1720G>A	c.(1720-1722)Gag>Aag	p.E574K	KCNT1_ENST00000491806.2_Missense_Mutation_p.E541K|KCNT1_ENST00000487664.1_Missense_Mutation_p.E529K|KCNT1_ENST00000371757.2_Missense_Mutation_p.E574K|KCNT1_ENST00000263604.3_Missense_Mutation_p.E555K|KCNT1_ENST00000486577.2_Missense_Mutation_p.E535K|KCNT1_ENST00000490355.2_Missense_Mutation_p.E555K|KCNT1_ENST00000488444.2_Missense_Mutation_p.E555K			B7ZVY4	B7ZVY4_HUMAN	potassium channel, subfamily T, member 1	574						membrane	binding|calcium-activated potassium channel activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		GTTCTTCCGCGAGTACGAGGG	0.637000													5	147					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135161869	135161869	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr9:135161869C>G	ENST00000372169.2	-	18	6519	c.6337G>C	c.(6337-6339)Gat>Cat	p.D2113H	SETX_ENST00000224140.5_Missense_Mutation_p.D2113H|SETX_ENST00000393220.1_Missense_Mutation_p.D2113H			Q7Z333	SETX_HUMAN	senataxin	2113					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		ATGTTTTCATCTAATTCTTGC	0.303000													10	43					0	0	1	0	0
RPS6KA4	8986	broad.mit.edu	37	11	64129169	64129169	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr11:64129169C>T	ENST00000528057.1	+	7	795	c.707C>T	c.(706-708)tCg>tTg	p.S236L	RPS6KA4_ENST00000294261.4_Missense_Mutation_p.S236L|RPS6KA4_ENST00000334205.4_Missense_Mutation_p.S236L	NM_001006944.1	NP_001006945.1	O75676	KS6A4_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 4	236	Protein kinase 1.		S -> L (in a breast infiltrating ductal carcinoma sample; somatic mutation).		axon guidance|histone phosphorylation|interleukin-1-mediated signaling pathway|intracellular protein kinase cascade|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|magnesium ion binding|mitogen-activated protein kinase p38 binding|ribosomal protein S6 kinase activity	p.S236L(1)		breast(1)|endometrium(3)|lung(7)|ovary(1)|prostate(1)	13						ACGGGGGCCTCGCCCTTCACC	0.697000													31	24					0	0	1	0	0
ZNF627	199692	broad.mit.edu	37	19	11728286	11728286	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr19:11728286G>T	ENST00000361113.5	+	4	1176	c.968G>T	c.(967-969)aGa>aTa	p.R323I	ZNF627_ENST00000588174.1_3'UTR	NM_145295.3	NP_660338.1	Q7L945	ZN627_HUMAN	zinc finger protein 627	323					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	14						GCAAGTGTTAGAAGACACATG	0.448000													18	80					1.45105e-14	1.58822e-14	1	1	0
SPRY1	10252	broad.mit.edu	37	4	124322846	124322846	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr4:124322846C>T	ENST00000394339.2	+	2	440	c.100C>T	c.(100-102)Cag>Tag	p.Q34*	SPRY1_ENST00000339241.1_Nonsense_Mutation_p.Q34*	NM_001258039.1|NM_005841.2	NP_001244968.1|NP_005832.1	O43609	SPY1_HUMAN	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	34					epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|lamellipodium|plasma membrane				NS(1)|large_intestine(4)|lung(2)|ovary(1)|skin(3)	11						GAGAGAGATTCAGCCTACTGC	0.483000													12	246					0	0	1	0	0
SMPD3	55512	broad.mit.edu	37	16	68395554	68395554	+	Silent	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr16:68395554G>A	ENST00000219334.5	-	8	2421	c.1818C>T	c.(1816-1818)atC>atT	p.I606I	SMPD3_ENST00000568373.1_Silent_p.I589I|SMPD3_ENST00000563226.1_Silent_p.I598I	NM_018667.3	NP_061137.1	Q9NY59	NSMA2_HUMAN	sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)	606					cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)	GCATGTAGTCGATGCGCCGGC	0.662000													25	73					0	0	1	0	0
GCM1	8521	broad.mit.edu	37	6	52993371	52993371	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr6:52993371T>C	ENST00000259803.7	-	6	1155	c.944A>G	c.(943-945)aAt>aGt	p.N315S		NM_003643.3	NP_003634.2	Q9NP62	GCM1_HUMAN	glial cells missing homolog 1 (Drosophila)	315						transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|skin(1)	24	Lung NSC(77;0.0755)					AAAAGGATAATTGGAATAACA	0.493000													16	46					0	0	1	0	0
TCTEX1D1	200132	broad.mit.edu	37	1	67236080	67236080	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr1:67236080A>T	ENST00000282670.2	+	3	258	c.130A>T	c.(130-132)Act>Tct	p.T44S	TCTEX1D1_ENST00000491611.1_3'UTR	NM_152665.2	NP_689878.2	Q8N7M0	TC1D1_HUMAN	Tctex1 domain containing 1	44										large_intestine(2)|lung(10)|skin(1)	13						TTCTATGAGTACTGTGTCTTA	0.323000													24	58					0	0	1	0	0
ZZEF1	23140	broad.mit.edu	37	17	3920921	3920921	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr17:3920921T>A	ENST00000381638.2	-	48	7869	c.7745A>T	c.(7744-7746)cAg>cTg	p.Q2582L		NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	2582							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						GCTACGGCGCTGCTTGGCATA	0.602000													25	86					0	0	1	0	0
CHCHD1	118487	broad.mit.edu	37	10	75541896	75541896	+	Silent	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr10:75541896G>A	ENST00000372837.3	+	1	92	c.63G>A	c.(61-63)ctG>ctA	p.L21L	CHCHD1_ENST00000372833.5_Silent_p.L21L			Q96BP2	CHCH1_HUMAN	coiled-coil-helix-coiled-coil-helix domain containing 1	21						nucleus				breast(1)	1	Prostate(51;0.0112)					AGCCTGTGCTGAAGCCCAATA	0.677000													44	40					0	0	1	0	0
GPS2	2874	broad.mit.edu	37	17	7217235	7217235	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr17:7217235T>C	ENST00000380728.2	-	6	770	c.470A>G	c.(469-471)cAa>cGa	p.Q157R	GPS2_ENST00000389167.5_Missense_Mutation_p.Q157R|GPS2_ENST00000391950.3_Missense_Mutation_p.Q157R|RP11-542C16.2_ENST00000575474.1_3'UTR			Q13227	GPS2_HUMAN	G protein pathway suppressor 2	157					cell cycle|inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter	transcriptional repressor complex	GTPase inhibitor activity|protein binding|transcription corepressor activity			breast(1)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(1)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(4)	24		Prostate(122;0.157)				CGTAAGCACTTGGGGTCCAAA	0.512000													5	152					0	0	1	0	0
TP53BP2	7159	broad.mit.edu	37	1	223971891	223971891	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr1:223971891C>G	ENST00000391878.2	-	18	3670	c.2902G>C	c.(2902-2904)Gac>Cac	p.D968H	TP53BP2_ENST00000391879.2_Missense_Mutation_p.D330H|TP53BP2_ENST00000343537.7_Missense_Mutation_p.D1097H|TP53BP2_ENST00000498843.1_5'UTR	NM_005426.2	NP_005417.1	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2	1091	Mediates interaction with APC2.				apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(2)	29				GBM - Glioblastoma multiforme(131;0.0958)		TCATCTTCGTCTTCCCTGTGG	0.453000													23	113					0	0	1	0	0
TP53BP2	7159	broad.mit.edu	37	1	224008929	224008929	+	Silent	SNP	A	A	G			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr1:224008929A>G	ENST00000343537.7	-	2	459	c.168T>C	c.(166-168)tgT>tgC	p.C56C	TP53BP2_ENST00000391878.2_5'UTR	NM_001031685.2	NP_001026855.2	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2	50					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(2)	29				GBM - Glioblastoma multiforme(131;0.0958)		CACCAGAGCCACACCACACTT	0.478000													6	79					0	0	1	0	0
MARCH8	220972	broad.mit.edu	37	10	46028655	46028655	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr10:46028655C>T	ENST00000453424.2	-	2	266	c.5G>A	c.(4-6)aGc>aAc	p.S2N	MARCH8_ENST00000395769.2_Missense_Mutation_p.S2N|MARCH8_ENST00000395771.3_Missense_Mutation_p.S2N|MARCH8_ENST00000319836.3_Missense_Mutation_p.S2N	NM_001282866.1	NP_001269795.1	Q5T0T0	MARH8_HUMAN	membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase	2						cytoplasmic vesicle membrane|early endosome membrane|integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(4)	12						CAGTGGCATGCTCATCCCAAC	0.468000													3	16					0	0	1	0	0
UTRN	7402	broad.mit.edu	37	6	144869907	144869907	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr6:144869907G>T	ENST00000367545.3	+	46	6727	c.6727G>T	c.(6727-6729)Gta>Tta	p.V2243L		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	2243					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CGACTGGCTGGTATTAATCGA	0.413000													9	23					1.12685e-05	1.16388e-05	1	1	0
CALD1	800	broad.mit.edu	37	7	134617839	134617839	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr7:134617839C>T	ENST00000361388.2	+	5	785	c.319C>T	c.(319-321)Cgc>Tgc	p.R107C	CALD1_ENST00000543443.1_Missense_Mutation_p.R112C|CALD1_ENST00000422748.1_Missense_Mutation_p.R107C|CALD1_ENST00000361901.2_Missense_Mutation_p.R107C|CALD1_ENST00000495522.1_Missense_Mutation_p.R101C|CALD1_ENST00000424922.1_Missense_Mutation_p.R101C|CALD1_ENST00000361675.2_Missense_Mutation_p.R107C|CALD1_ENST00000393118.2_Missense_Mutation_p.R101C|CALD1_ENST00000417172.1_Missense_Mutation_p.R107C	NM_033138.3|NM_033157.3	NP_149129.2|NP_149347.2	Q05682	CALD1_HUMAN	caldesmon 1	314	Myosin and calmodulin-binding (By similarity).				cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(15)|lung(10)	43						TGAGGAAAGACGCCAAAAACG	0.552000													32	38					0	0	1	0	0
EFHC1	114327	broad.mit.edu	37	6	52344502	52344502	+	Silent	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr6:52344502C>T	ENST00000371068.5	+	9	1660	c.1557C>T	c.(1555-1557)aaC>aaT	p.N519N	EFHC1_ENST00000433625.2_Silent_p.N428N|EFHC1_ENST00000538167.1_Silent_p.N500N	NM_018100.3	NP_060570.2	Q5JVL4	EFHC1_HUMAN	EF-hand domain (C-terminal) containing 1	519	DM10 3.					axoneme|neuronal cell body	calcium ion binding|protein C-terminus binding			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(8)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	27	Lung NSC(77;0.109)					TGGAGAGCAACGCTGCCCAGT	0.478000													26	53					0	0	1	0	0
SLFN12	55106	broad.mit.edu	37	17	33749394	33749394	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr17:33749394A>C	ENST00000394562.1	-	4	1177	c.654T>G	c.(652-654)atT>atG	p.I218M	SLFN12_ENST00000452764.3_Missense_Mutation_p.I218M|SLFN12_ENST00000304905.5_Missense_Mutation_p.I218M			Q8IYM2	SLN12_HUMAN	schlafen family member 12	218							ATP binding			breast(1)|kidney(2)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GAATCTCTTTAATTCGTTGTA	0.308000													30	118					0	0	1	0	0
POU4F2	5458	broad.mit.edu	37	4	147560402	147560402	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr4:147560402C>G	ENST00000281321.3	+	1	358	c.110C>G	c.(109-111)tCg>tGg	p.S37W		NM_004575.2	NP_004566.2	Q12837	PO4F2_HUMAN	POU class 4 homeobox 2	37					estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			NS(1)|breast(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)					CCGGGCTCCTCGGCTCCCATC	0.736000													11	7					0	0	1	0	0
PCBP4	57060	broad.mit.edu	37	3	51994080	51994080	+	Nonsense_Mutation	SNP	A	A	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr3:51994080A>T	ENST00000395014.2	-	2	409	c.410T>A	c.(409-411)tTa>tAa	p.L137*	PCBP4_ENST00000484633.1_Intron|PCBP4_ENST00000355852.2_Intron|PCBP4_ENST00000471622.1_Intron|PCBP4_ENST00000322099.7_Intron|PCBP4_ENST00000428823.2_Intron|PCBP4_ENST00000461554.1_Intron|PCBP4_ENST00000395013.3_Intron			P57723	PCBP4_HUMAN	poly(rC) binding protein 4	128	KH 2.					cytoplasm|ribonucleoprotein complex	DNA binding|RNA binding			endometrium(2)|large_intestine(2)|lung(2)|prostate(1)|stomach(1)	8				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CTGCTCCCATAACCCAGAAAA	0.612000													5	71					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95522815	95522815	+	RNA	SNP	A	A	G			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr2:95522815A>G	ENST00000432432.2	-	0	212					NR_040113.1																						ATCTTCTGCAATTCGGAGTCC	0.652000													4	53					0	0	1	0	0
DYX1C1	161582	broad.mit.edu	37	15	55790469	55790469	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr15:55790469G>A	ENST00000321149.3	-	2	426	c.59C>T	c.(58-60)tCt>tTt	p.S20F	DYX1C1-CCPG1_ENST00000565113.1_RNA|DYX1C1_ENST00000448430.2_Missense_Mutation_p.S20F|DYX1C1_ENST00000457155.2_Missense_Mutation_p.S20F|DYX1C1_ENST00000380679.1_Missense_Mutation_p.S20F|DYX1C1_ENST00000348518.3_Missense_Mutation_p.S20F	NM_130810.3	NP_570722.2	Q8WXU2	DYXC1_HUMAN	dyslexia susceptibility 1 candidate 1	20	CS.|Mediates interaction with ESR1 and STUB1.				neuron migration|regulation of estrogen receptor signaling pathway|regulation of proteasomal protein catabolic process	cytoplasm|nucleus	estrogen receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18				all cancers(107;0.0118)|GBM - Glioblastoma multiforme(80;0.171)		GAGGGGCAGAGACAGAAAGAC	0.567000													11	35					0	0	1	0	0
KIFC3	3801	broad.mit.edu	37	16	57796128	57796128	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr16:57796128C>T	ENST00000379655.4	-	13	1929	c.1672G>A	c.(1672-1674)Gag>Aag	p.E558K	KIFC3_ENST00000539578.1_Missense_Mutation_p.E500K|KIFC3_ENST00000541240.1_Missense_Mutation_p.E580K|KIFC3_ENST00000543930.1_Missense_Mutation_p.E416K|KIFC3_ENST00000465878.2_Missense_Mutation_p.E419K|KIFC3_ENST00000445690.2_Missense_Mutation_p.E558K|KIFC3_ENST00000421376.2_Missense_Mutation_p.E419K|KIFC3_ENST00000562903.1_Missense_Mutation_p.E419K|KIFC3_ENST00000540079.2_Missense_Mutation_p.E456K	NM_005550.3	NP_005541.3	Q9BVG8	KIFC3_HUMAN	kinesin family member C3	558	Kinesin-motor.				epithelial cell-cell adhesion|microtubule-based movement|visual perception|zonula adherens maintenance	centrosome|cytoplasmic vesicle membrane|kinesin complex|microtubule|zonula adherens	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(3)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23		all_neural(199;0.224)				TCCTGCACCTCGGAGAAGAGC	0.627000													7	20					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29628243	29628243	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr20:29628243T>C	ENST00000278882.3	+	6	625	c.245T>C	c.(244-246)tTg>tCg	p.L82S	FRG1B_ENST00000439954.2_Missense_Mutation_p.L87S|FRG1B_ENST00000358464.4_Missense_Mutation_p.L82S														p.L82S(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGGCTTTGTTGGCCTCAAAT	0.363000													4	153					0	0	1	0	0
FAM19A5	25817	broad.mit.edu	37	22	49042442	49042442	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr22:49042442C>G	ENST00000358295.5	+	2	300	c.125C>G	c.(124-126)aCc>aGc	p.T42S	FAM19A5_ENST00000473898.1_Intron|FAM19A5_ENST00000402357.1_Missense_Mutation_p.T49S	NM_015381.5	NP_056196.2	Q7Z5A7	F19A5_HUMAN	family with sequence similarity 19 (chemokine (C-C motif)-like), member A5	49						extracellular region|integral to membrane				large_intestine(1)|lung(6)	7		all_cancers(38;2.95e-11)|all_epithelial(38;3.07e-10)|all_lung(38;2.89e-05)|Breast(42;0.000396)|Lung NSC(38;0.000471)|Ovarian(80;0.00934)|Lung SC(80;0.195)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0227)|BRCA - Breast invasive adenocarcinoma(115;0.119)		GAGATTGTGACCTTGGACCGG	0.677000													5	26					0	0	1	0	0
OTUD5	55593	broad.mit.edu	37	X	48781020	48781020	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chrX:48781020G>A	ENST00000156084.4	-	8	1544	c.1484C>T	c.(1483-1485)aCa>aTa	p.T495I	OTUD5_ENST00000428668.2_Missense_Mutation_p.T273I|OTUD5_ENST00000396743.3_Missense_Mutation_p.T490I|OTUD5_ENST00000376488.3_Missense_Mutation_p.T490I	NM_017602.3	NP_060072.1	Q96G74	OTUD5_HUMAN	OTU domain containing 5	495					negative regulation of type I interferon production		cysteine-type peptidase activity			endometrium(2)|large_intestine(3)|lung(6)|pancreas(2)	13						CTGACTGCTTGTACCTGAAGC	0.617000													10	7					0	0	1	0	0
LTN1	26046	broad.mit.edu	37	21	30338214	30338214	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr21:30338214C>A	ENST00000389194.2	-	11	2279	c.2274G>T	c.(2272-2274)tgG>tgT	p.W758C	LTN1_ENST00000389195.2_Missense_Mutation_p.W758C|LTN1_ENST00000361371.5_Missense_Mutation_p.W712C	NM_015565.2	NP_056380.2	O94822	LTN1_HUMAN	listerin E3 ubiquitin protein ligase 1	712							ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(19)|ovary(5)|pancreas(1)|prostate(2)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)	60						GAAGAGAATTCCATTTCAAGT	0.303000													6	14					8.12818e-05	8.24056e-05	1	1	0
LRRK2	120892	broad.mit.edu	37	12	40757337	40757337	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr12:40757337G>A	ENST00000298910.7	+	48	7220	c.7162G>A	c.(7162-7164)Gac>Aac	p.D2388N		NM_198578.3	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2388					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TGGACTAATAGACTGCGTGCA	0.373000													7	28					0	0	1	0	0
CROCCP2	84809	broad.mit.edu	37	1	16946438	16946438	+	RNA	SNP	G	G	A	rs28392876	by1000genomes	TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr1:16946438G>A	ENST00000412962.1	-	0	1081																											GCCTTCCGCCGGGCCAGCAGC	0.672000													3	24					0	0	1	0	0
RHCG	51458	broad.mit.edu	37	15	90022685	90022685	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr15:90022685G>C	ENST00000268122.4	-	5	773	c.705C>G	c.(703-705)ttC>ttG	p.F235L	RHCG_ENST00000544600.1_Missense_Mutation_p.F235L	NM_016321.1	NP_057405.1	Q9UBD6	RHCG_HUMAN	Rh family, C glycoprotein	235					amine transport|cellular ion homeostasis|epithelial cell differentiation|transepithelial ammonium transport	apical plasma membrane|basolateral plasma membrane|cytoplasmic vesicle|integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Lung NSC(78;0.0237)|all_lung(78;0.0478)					TGGCTGAGTTGAAGCTGGGCC	0.597000													22	27					0	0	1	0	0
MEF2A	4205	broad.mit.edu	37	15	100214790	100214790	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr15:100214790C>T	ENST00000354410.5	+	6	1218	c.589C>T	c.(589-591)Cag>Tag	p.Q197*	MEF2A_ENST00000453228.2_Nonsense_Mutation_p.Q195*|MEF2A_ENST00000557785.1_Nonsense_Mutation_p.Q195*|MEF2A_ENST00000449277.2_Nonsense_Mutation_p.Q127*|MEF2A_ENST00000558812.1_Nonsense_Mutation_p.Q127*|MEF2A_ENST00000557942.1_Nonsense_Mutation_p.Q195*|MEF2A_ENST00000338042.6_Nonsense_Mutation_p.Q195*	NM_005587.2	NP_005578.2	Q02078	MEF2A_HUMAN	myocyte enhancer factor 2A	197					apoptosis|BMK cascade|cardiac conduction|cellular response to calcium ion|dendrite morphogenesis|innate immune response|mitochondrial genome maintenance|mitochondrion distribution|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|ventricular cardiac myofibril development	nuclear chromatin|nucleoplasm	activating transcription factor binding|histone acetyltransferase binding|histone deacetylase binding|protein heterodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|SMAD binding			endometrium(2)|large_intestine(2)|lung(7)|ovary(1)	12	Lung NSC(78;0.00335)|all_lung(78;0.00659)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00085)			TGGAGCTCCTCAGAGACCACC	0.433000													39	144					0	0	1	0	0
DNER	92737	broad.mit.edu	37	2	230456365	230456365	+	Silent	SNP	C	C	T	rs138325902		TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr2:230456365C>T	ENST00000341772.4	-	2	650	c.516G>A	c.(514-516)acG>acA	p.T172T		NM_139072.3	NP_620711.3	Q8NFT8	DNER_HUMAN	delta/notch-like EGF repeat containing	172					central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	63		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		GCAGTGTCACCGTTGCCTGAG	0.522000													10	12					0	0	1	0	0
NKG7	4818	broad.mit.edu	37	19	51875546	51875546	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr19:51875546G>A	ENST00000221978.5	-	2	352	c.173C>T	c.(172-174)aCg>aTg	p.T58M	NKG7_ENST00000600427.1_Intron|NKG7_ENST00000595217.1_Intron	NM_005601.3	NP_005592.1	Q16617	NKG7_HUMAN	natural killer cell group 7 sequence	58						integral to plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000211)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GAAGGTCTGCGTCACGTGGAT	0.607000													44	228					0	0	1	0	0
ZNF419	79744	broad.mit.edu	37	19	57999139	57999139	+	Translation_Start_Site	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr19:57999139G>A	ENST00000424930.2	+	0	50				ZNF419_ENST00000520540.1_De_novo_Start_OutOfFrame|ZNF419_ENST00000347466.6_De_novo_Start_OutOfFrame|ZNF419_ENST00000415379.2_De_novo_Start_OutOfFrame|ZNF419_ENST00000354197.4_De_novo_Start_OutOfFrame|ZNF419_ENST00000442920.2_De_novo_Start_OutOfFrame|AC003005.4_ENST00000601674.1_De_novo_Start_OutOfFrame|ZNF419_ENST00000426954.2_De_novo_Start_OutOfFrame|ZNF419_ENST00000221735.7_De_novo_Start_OutOfFrame|ZNF419_ENST00000518999.1_5'UTR	NM_001098491.1|NM_024691.3	NP_001091961.1|NP_078967.3	Q96HQ0	ZN419_HUMAN	zinc finger protein 419						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0252)|Lung(386;0.171)		TCGCGACTCAGGTGAACTAAC	0.627000													7	8					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95480631	95480631	+	RNA	SNP	T	T	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr2:95480631T>C	ENST00000432432.2	-	0	2729					NR_040113.1																						ccccagccccttgcaaacatt	0.393000													4	11					0	0	1	0	0
PDGFD	80310	broad.mit.edu	37	11	103870975	103870975	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr11:103870975G>A	ENST00000393158.2	-	2	312	c.133C>T	c.(133-135)Cac>Tac	p.H45Y	PDGFD_ENST00000302251.5_Intron			Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D	45					positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)	23		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		TCTGTGAGGTGATTGCTCTCT	0.433000													26	65					0	0	1	0	0
ERBB3	2065	broad.mit.edu	37	12	56478852	56478852	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr12:56478852G>A	ENST00000267101.3	+	3	748	c.308G>A	c.(307-309)cGc>cAc	p.R103H	ERBB3_ENST00000450146.2_Intron|ERBB3_ENST00000415288.2_Missense_Mutation_p.R44H|ERBB3_ENST00000411731.2_Missense_Mutation_p.R103H	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	103					cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity	p.R103H(1)		central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CCCAACCTCCGCGTGGTGCGA	0.517000													13	140					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124237266	124237266	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr3:124237266G>A	ENST00000240874.3	+	34	5106	c.4949G>A	c.(4948-4950)cGg>cAg	p.R1650Q	KALRN_ENST00000360013.3_Intron|KALRN_ENST00000393496.1_Intron|KALRN_ENST00000460856.1_Missense_Mutation_p.R1641Q	NM_003947.4	NP_003938.1	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	0	SH3 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						CTTGTTCCTCGGTGGCACCTG	0.527000													34	86					0	0	1	0	0
DLGAP1	9229	broad.mit.edu	37	18	3582077	3582077	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr18:3582077G>T	ENST00000315677.3	-	8	2356	c.1761C>A	c.(1759-1761)agC>agA	p.S587R	DLGAP1_ENST00000400149.3_Missense_Mutation_p.S277R|DLGAP1_ENST00000400147.2_Missense_Mutation_p.S285R|DLGAP1_ENST00000539435.1_Missense_Mutation_p.S295R|DLGAP1_ENST00000584874.1_Missense_Mutation_p.S587R|DLGAP1_ENST00000581699.1_Missense_Mutation_p.S293R|DLGAP1_ENST00000400155.1_Missense_Mutation_p.S293R|DLGAP1_ENST00000400145.2_Missense_Mutation_p.S285R|DLGAP1_ENST00000534970.1_Missense_Mutation_p.S271R|DLGAP1_ENST00000581527.1_Missense_Mutation_p.S587R|DLGAP1_ENST00000400150.3_Missense_Mutation_p.S303R|DLGAP1_ENST00000515196.2_Missense_Mutation_p.S587R	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	587					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				CGGTGGAGTTGCTGAGTCCAG	0.557000													25	53					5.35047e-06	5.57869e-06	1	1	0
WHAMM	123720	broad.mit.edu	37	15	83481871	83481871	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr15:83481871G>A	ENST00000286760.4	+	2	725	c.626G>A	c.(625-627)gGa>gAa	p.G209E		NM_001080435.1	NP_001073904.1	Q8TF30	WHAMM_HUMAN	WAS protein homolog associated with actin, golgi membranes and microtubules	209						cytoplasmic vesicle membrane|ER-Golgi intermediate compartment|Golgi apparatus	actin binding			endometrium(6)|large_intestine(5)|lung(1)|prostate(1)	13						CAAGGACACGGAAAAGCCAAC	0.378000													12	26					0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23545443	23545443	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr19:23545443T>C	ENST00000300619.7	-	4	543	c.338A>G	c.(337-339)gAa>gGa	p.E113G	ZNF91_ENST00000397082.2_Missense_Mutation_p.E81G|ZNF91_ENST00000599743.1_Intron	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	113						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TCCACATTTTTCATATTTTCT	0.333000													23	94					0	0	1	0	0
CLEC16A	23274	broad.mit.edu	37	16	11071190	11071190	+	Silent	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr16:11071190C>T	ENST00000409790.1	+	8	1067	c.837C>T	c.(835-837)ctC>ctT	p.L279L	CLEC16A_ENST00000409552.3_Silent_p.L277L	NM_015226.2	NP_056041.1	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	279										breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						ACGATGTGCTCACTGACCACC	0.557000													5	234					0	0	1	0	0
PCBP4	57060	broad.mit.edu	37	3	51992103	51992103	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr3:51992103C>T	ENST00000461554.1	-	14	1517	c.1186G>A	c.(1186-1188)Gag>Aag	p.E396K	PCBP4_ENST00000484633.1_Missense_Mutation_p.E353K|PCBP4_ENST00000355852.2_Missense_Mutation_p.E396K|PCBP4_ENST00000471622.1_3'UTR|PCBP4_ENST00000322099.7_Missense_Mutation_p.E396K|PCBP4_ENST00000428823.2_Missense_Mutation_p.E353K|PCBP4_ENST00000395014.2_Missense_Mutation_p.E417K|PCBP4_ENST00000395013.3_Missense_Mutation_p.E236K	NM_001174100.1	NP_001167571.1	P57723	PCBP4_HUMAN	poly(rC) binding protein 4	396						cytoplasm|ribonucleoprotein complex	DNA binding|RNA binding			endometrium(2)|large_intestine(2)|lung(2)|prostate(1)|stomach(1)	8				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		TTCTGCCGCTCAGCCTTCTTG	0.652000													56	129					0	0	1	0	0
ATP5B	506	broad.mit.edu	37	12	57039721	57039721	+	Silent	SNP	G	G	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr12:57039721G>T	ENST00000262030.3	-	1	77	c.27C>A	c.(25-27)gcC>gcA	p.A9A	ATP5B_ENST00000552919.1_Silent_p.A9A	NM_001686.3	NP_001677.2	P06576	ATPB_HUMAN	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	9					angiogenesis|ATP hydrolysis coupled proton transport|regulation of intracellular pH|respiratory electron transport chain	cell surface|mitochondrial nucleoid|mitochondrial proton-transporting ATP synthase, catalytic core|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|hydrogen-exporting ATPase activity, phosphorylative mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CCGGAGCAGCGGCCACCCGAC	0.692000													3	6					6.4e-05	6.54884e-05	1	1	0
ITGB8	3696	broad.mit.edu	37	7	20444283	20444283	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr7:20444283T>A	ENST00000222573.4	+	11	2404	c.1720T>A	c.(1720-1722)Tgc>Agc	p.C574S	ITGB8_ENST00000537992.1_Missense_Mutation_p.C439S	NM_002214.2	NP_002205.1	P26012	ITB8_HUMAN	integrin, beta 8		Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(17)|prostate(2)|skin(4)|stomach(2)|urinary_tract(1)	37						CAGATGCCAATGCTTCAGTGG	0.527000													10	26					0	0	1	0	0
NPSR1	387129	broad.mit.edu	37	7	34888169	34888169	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr7:34888169G>A	ENST00000360581.1	+	8	1047	c.919G>A	c.(919-921)Gag>Aag	p.E307K	NPSR1_ENST00000531252.1_Missense_Mutation_p.E296K|NPSR1_ENST00000381542.1_Missense_Mutation_p.E241K|NPSR1_ENST00000381539.3_Missense_Mutation_p.E307K|NPSR1_ENST00000359791.1_Missense_Mutation_p.E307K	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	307						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	AGACACCCAGGAGCGTTTCTA	0.488000													75	210					0	0	1	0	0
SYT2	127833	broad.mit.edu	37	1	202568473	202568473	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr1:202568473T>C	ENST00000367267.1	-	8	1118	c.926A>G	c.(925-927)tAc>tGc	p.Y309C	SYT2_ENST00000367268.4_Missense_Mutation_p.Y309C	NM_001136504.1	NP_001129976.1	Q8N9I0	SYT2_HUMAN	synaptotagmin II	309	C2 2.|Phospholipid binding (By similarity).				neurotransmitter secretion	cell junction|chromaffin granule membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	protein binding|transporter activity			NS(1)|breast(4)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(9)|ovary(2)|skin(2)|urinary_tract(1)	29			BRCA - Breast invasive adenocarcinoma(75;0.169)		Botulinum Toxin Type B(DB00042)	GATCTTCACGTACGGGTCTGC	0.552000													35	98					0	0	1	0	0
FASTK	10922	broad.mit.edu	37	7	150776703	150776703	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr7:150776703C>T	ENST00000540185.1	-	2	891	c.287G>A	c.(286-288)cGg>cAg	p.R96Q	FASTK_ENST00000489884.1_Intron|FASTK_ENST00000482571.1_Missense_Mutation_p.R130Q|FASTK_ENST00000297532.6_Missense_Mutation_p.R130Q|FASTK_ENST00000353841.2_Intron			Q14296	FASTK_HUMAN	Fas-activated serine/threonine kinase	130					apoptosis|induction of apoptosis by extracellular signals|regulation of RNA splicing		ATP binding|Fas-activated serine/threonine kinase activity|protein binding			lung(4)|stomach(2)	6			OV - Ovarian serous cystadenocarcinoma(82;0.00989)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)|LUSC - Lung squamous cell carcinoma(290;0.0718)|Lung(243;0.138)		AGGAGGGGGCCGTGGCCGAGA	0.637000													4	38					0	0	1	0	0
C1QTNF7	114905	broad.mit.edu	37	4	15444237	15444237	+	Silent	SNP	T	T	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr4:15444237T>C	ENST00000295297.4	+	3	964	c.705T>C	c.(703-705)caT>caC	p.H235H	C1QTNF7_ENST00000429690.1_Silent_p.H228H|C1QTNF7_ENST00000444304.2_Silent_p.H228H	NM_001135170.1	NP_001128642.1	Q9BXJ2	C1QT7_HUMAN	C1q and tumor necrosis factor related protein 7	228	C1q.					collagen				endometrium(5)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|stomach(1)	16						CAGGAAACCATGATGTGGCTT	0.478000													32	153					0	0	1	0	0
HSPA4L	22824	broad.mit.edu	37	4	128703775	128703775	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr4:128703775G>T	ENST00000296464.4	+	1	481	c.70G>T	c.(70-72)Gag>Tag	p.E24*	HSPA4L_ENST00000439123.2_Nonsense_Mutation_p.E55*|HSPA4L_ENST00000508776.1_Nonsense_Mutation_p.E24*	NM_014278.2	NP_055093.2	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like						protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	31						TGGCGGCATCGAGACCATCGC	0.562000											OREG0016319	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	25					3.27435e-08	3.47999e-08	1	1	0
POLA2	23649	broad.mit.edu	37	11	65046299	65046299	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr11:65046299G>A	ENST00000265465.3	+	6	1091	c.560G>A	c.(559-561)gGa>gAa	p.G187E	POLA2_ENST00000541089.1_5'UTR	NM_002689.2	NP_002680.2	Q14181	DPOA2_HUMAN	polymerase (DNA directed), alpha 2, accessory subunit	187					DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	nucleoplasm	DNA binding			endometrium(1)|large_intestine(2)|lung(7)|urinary_tract(1)	11					Dacarbazine(DB00851)	GGGAGAGGAGGAGCTGGAAAC	0.507000													41	99					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1101652	1101652	+	Silent	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr11:1101652C>T	ENST00000441003.2	+	42	7692	c.7665C>T	c.(7663-7665)ttC>ttT	p.F2555F		NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	4917						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	GCTGTCCTTTCTACTGGTGTG	0.632000													28	61					0	0	1	0	0
HCG17	414778	broad.mit.edu	37	6	30231143	30231143	+	RNA	SNP	T	T	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr6:30231143T>C	ENST00000453558.1	-	0	126				HLA-L_ENST00000463348.1_RNA																							GGAGTCATTTTTCCTGTCATT	0.488000													14	235					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140176085	140176085	+	Silent	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr5:140176085G>A	ENST00000526136.1	+	1	1536	c.1536G>A	c.(1534-1536)gcG>gcA	p.A512A	PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000378132.1_Silent_p.A512A|PCDHA2_ENST00000520672.2_Silent_p.A512A|PCDHA1_ENST00000504120.2_Intron	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGTGCACGCGGAGAGCGGCA	0.701000													6	145					0	0	1	0	0
TNRC6A	27327	broad.mit.edu	37	16	24808846	24808846	+	Silent	SNP	G	G	A	rs150034813		TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr16:24808846G>A	ENST00000395799.3	+	10	3726	c.3597G>A	c.(3595-3597)gcG>gcA	p.A1199A	TNRC6A_ENST00000315183.7_Silent_p.A1199A	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1199	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		AAGAAGAAGCGTGGATAAATC	0.363000													10	27					0	0	1	0	0
ANKRD13C	81573	broad.mit.edu	37	1	70819715	70819715	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr1:70819715C>T	ENST00000370944.4	-	1	690	c.377G>A	c.(376-378)aGg>aAg	p.R126K	ANKRD13C_ENST00000262346.6_Missense_Mutation_p.R126K	NM_030816.4	NP_110443.3	Q8N6S4	AN13C_HUMAN	ankyrin repeat domain 13C	126					protein retention in ER lumen|regulation of anoikis|regulation of receptor biosynthetic process	endoplasmic reticulum membrane|perinuclear region of cytoplasm	receptor binding			endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(1)	19						GGAGAGTCTCCTCACATCCCC	0.617000													14	13					0	0	1	0	0
NFATC2	4773	broad.mit.edu	37	20	50140482	50140482	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr20:50140482C>T	ENST00000371564.3	-	2	517	c.298G>A	c.(298-300)Gcg>Acg	p.A100T	NFATC2_ENST00000609943.1_Missense_Mutation_p.A80T|NFATC2_ENST00000610033.1_Intron|NFATC2_ENST00000609507.1_Intron|NFATC2_ENST00000396009.3_Missense_Mutation_p.A100T|NFATC2_ENST00000414705.1_Missense_Mutation_p.A80T	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	100					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					GGCTTGGCCGCGCTCAGAAAC	0.662000													22	89					0	0	1	0	0
PLEKHG3	26030	broad.mit.edu	37	14	65210004	65210004	+	Silent	SNP	G	G	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr14:65210004G>T	ENST00000247226.7	+	15	3383	c.3075G>T	c.(3073-3075)tcG>tcT	p.S1025S	PLEKHG3_ENST00000484731.2_Silent_p.S586S|PLEKHG3_ENST00000471182.2_Silent_p.S614S|PLEKHG3_ENST00000492928.1_Intron|PLEKHG3_ENST00000394691.1_Silent_p.S1081S	NM_015549.1	NP_056364.1	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	1081					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(5)|kidney(2)|large_intestine(1)|lung(14)|prostate(2)|skin(3)|urinary_tract(2)	29				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		GGAGCCACTCGGTGCCGGAGA	0.716000													23	37					7.87624e-14	8.53583e-14	1	1	0
ASXL2	55252	broad.mit.edu	37	2	25972633	25972633	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr2:25972633G>A	ENST00000435504.4	-	12	2085	c.1792C>T	c.(1792-1794)Cag>Tag	p.Q598*	ASXL2_ENST00000404843.1_Nonsense_Mutation_p.Q338*|ASXL2_ENST00000272341.4_Nonsense_Mutation_p.Q338*|ASXL2_ENST00000336112.4_Nonsense_Mutation_p.Q570*			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	598					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGTGAGACCTGAAATGGCTGC	0.522000													9	42					0	0	1	0	0
FBXW2	26190	broad.mit.edu	37	9	123526953	123526953	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr9:123526953C>T	ENST00000608872.1	-	8	1436	c.1249G>A	c.(1249-1251)Gca>Aca	p.A417T	FBXW2_ENST00000493559.1_Intron|FBXW2_ENST00000340778.5_Missense_Mutation_p.A352T	NM_012164.3	NP_036296.2	Q9UKT8	FBXW2_HUMAN	F-box and WD repeat domain containing 2						proteolysis		protein binding|ubiquitin-protein ligase activity			ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	4						GCTTCGCCTGCCAGGAAGCTT	0.547000													51	131					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183245281	183245281	+	Silent	SNP	C	C	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr4:183245281C>A	ENST00000511685.1	+	2	231	c.108C>A	c.(106-108)ccC>ccA	p.P36P	TENM3_ENST00000406950.2_Silent_p.P36P					teneurin transmembrane protein 3																		GCCGGGTACCCACACAGAAGT	0.517000													23	60					2.21704e-12	2.39092e-12	1	1	0
SDK1	221935	broad.mit.edu	37	7	4050746	4050746	+	Splice_Site	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr7:4050746G>A	ENST00000404826.2	+	15	2418		c.e15+1		SDK1_ENST00000389531.3_Splice_Site	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1						cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		AGACAAGCAGGTGCGTGAATC	0.607000													24	8					0	0	1	0	0
STK32B	55351	broad.mit.edu	37	4	5461922	5461922	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr4:5461922C>A	ENST00000282908.5	+	9	1298	c.876C>A	c.(874-876)ttC>ttA	p.F292L	STK32B_ENST00000508728.1_3'UTR|STK32B_ENST00000512636.1_Missense_Mutation_p.F215L|STK32B_ENST00000510398.1_Missense_Mutation_p.F245L	NM_018401.1	NP_060871.1	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	292							ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	39						ACGCGGTGTTCAAGAAGGCAC	0.587000											OREG0016061	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	114					1.9806e-07	2.07491e-07	1	1	0
EFTUD2	9343	broad.mit.edu	37	17	42937369	42937369	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr17:42937369G>C	ENST00000426333.2	-	18	2061	c.1764C>G	c.(1762-1764)atC>atG	p.I588M	EFTUD2_ENST00000591382.1_Missense_Mutation_p.I588M|EFTUD2_ENST00000592576.1_Missense_Mutation_p.I578M|EFTUD2_ENST00000402521.3_Missense_Mutation_p.I553M	NM_001142605.1|NM_001258354.1|NM_004247.3	NP_001136077.1|NP_001245283.1|NP_004238.3	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain containing 2	588						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	32		Prostate(33;0.109)				CAGCAATCTTGATAACAGATG	0.507000													67	168					0	0	1	0	0
LRRC37A11P	342666	broad.mit.edu	37	17	37188442	37188442	+	RNA	SNP	G	G	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr17:37188442G>C	ENST00000425901.2	+	0	2284					NR_033753.2																						ATCGAAACCTGACTGAAGTCA	0.483000													50	134					0	0	1	0	0
ADH1A	124	broad.mit.edu	37	4	100201316	100201316	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr4:100201316C>T	ENST00000209668.2	-	7	1062	c.949G>A	c.(949-951)Gga>Aga	p.G317R	RP11-696N14.1_ENST00000500358.2_RNA|RP11-696N14.1_ENST00000506160.1_RNA	NM_000667.3	NP_000658.1	P07327	ADH1A_HUMAN	alcohol dehydrogenase 1A (class I), alpha polypeptide	317					ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)	25				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)	AGAATAGCTCCCTTCCAGGTA	0.463000													113	171					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167802338	167802338	+	Silent	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr1:167802338G>A	ENST00000367848.1	-	25	3701	c.3204C>T	c.(3202-3204)ctC>ctT	p.L1068L	ADCY10_ENST00000367851.4_Silent_p.L1160L|ADCY10_ENST00000545172.1_Silent_p.L1007L			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	1160					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						TTCGGTTGAGGAGCTTCAGTG	0.453000													13	276					0	0	1	0	0
UNC119	9094	broad.mit.edu	37	17	26874858	26874858	+	Silent	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr17:26874858G>A	ENST00000484980.1	-	3	3323	c.162C>T	c.(160-162)ttC>ttT	p.F54F	UNC119_ENST00000301032.4_Silent_p.F149F|UNC119_ENST00000470125.1_Silent_p.F54F|UNC119_ENST00000335765.4_Silent_p.F149F			Q13432	U119A_HUMAN	unc-119 homolog (C. elegans)	149					phototransduction|synaptic transmission|visual perception	cytosol|soluble fraction				breast(1)|large_intestine(1)|lung(3)|prostate(1)|stomach(1)	7	Lung NSC(42;0.00431)					CTCCCACTGTGAACTCCACCC	0.542000											OREG0024277	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	59	99					0	0	1	0	0
KCNA3	3738	broad.mit.edu	37	1	111216889	111216889	+	Silent	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr1:111216889G>A	ENST00000369769.2	-	1	766	c.543C>T	c.(541-543)tcC>tcT	p.S181S		NM_002232.3	NP_002223.3	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 3	181						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(7)|ovary(4)|pancreas(1)|prostate(3)|skin(1)	38		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGATCTCCTCGGAGAAAATGT	0.667000													30	122					0	0	1	0	0
GPX7	2882	broad.mit.edu	37	1	53072441	53072441	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr1:53072441G>A	ENST00000361314.4	+	2	262	c.224G>A	c.(223-225)gGc>gAc	p.G75D	GPX7_ENST00000459779.1_3'UTR	NM_015696.4	NP_056511.2	Q96SL4	GPX7_HUMAN	glutathione peroxidase 7	75				GPH -> HED (in Ref. 7).	response to oxidative stress	extracellular region	glutathione peroxidase activity			breast(1)|kidney(1)|lung(4)|upper_aerodigestive_tract(1)	7					Glutathione(DB00143)	CGAGACCTGGGCCCCCACCAC	0.602000													13	101					0	0	1	0	0
RPS6KA6	27330	broad.mit.edu	37	X	83362045	83362045	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chrX:83362045G>A	ENST00000262752.2	-	14	1122	c.1115C>T	c.(1114-1116)tCt>tTt	p.S372F	RPS6KA6_ENST00000543399.1_Missense_Mutation_p.S372F	NM_014496.4	NP_055311.1	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 6	372	AGC-kinase C-terminal.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.S372Y(1)		NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(26)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	46						CAAACCGGGAGAATCTAATGT	0.328000													11	12					0	0	1	0	0
ERCC6-PGBD3	101243544	broad.mit.edu	37	10	50724323	50724323	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr10:50724323G>A	ENST00000515869.1	-	6	2362	c.2242C>T	c.(2242-2244)Cac>Tac	p.H748Y	PGBD3_ENST00000374127.3_Missense_Mutation_p.H280Y|ERCC6_ENST00000355832.5_Intron|PGBD3_ENST00000508005.2_Missense_Mutation_p.H280Y|PGBD3_ENST00000603152.1_Missense_Mutation_p.H748Y|ERCC6-PGBD3_ENST00000447839.2_Missense_Mutation_p.H748Y	NM_001277059.1	NP_001263988.1																					TTGCACCCGTGACGACCAAAA	0.423000													12	17					0	0	1	0	0
ARSI	340075	broad.mit.edu	37	5	149677614	149677614	+	Silent	SNP	G	G	A	rs147391838		TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr5:149677614G>A	ENST00000328668.7	-	2	1452	c.873C>T	c.(871-873)gtC>gtT	p.V291V		NM_001012301.2	NP_001012301.1	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I	291						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGAAGATGATGACACTGTTGT	0.607000													12	29					0	0	1	0	0
RIMBP2	23504	broad.mit.edu	37	12	130934768	130934768	+	Silent	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr12:130934768G>A	ENST00000261655.4	-	6	670	c.507C>T	c.(505-507)gtC>gtT	p.V169V	RIMBP2_ENST00000535703.1_Silent_p.V77V|RIMBP2_ENST00000536002.1_Silent_p.V77V	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	169	SH3 1.					cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		CACAGAGGTGGACCTTCCCCG	0.557000													3	10					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62545169	62545169	+	Silent	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr1:62545169C>T	ENST00000371158.2	+	32	4287	c.4173C>T	c.(4171-4173)ttC>ttT	p.F1391F	INADL_ENST00000316485.6_Silent_p.F1391F|INADL_ENST00000543708.1_Silent_p.F175F|INADL_ENST00000545929.1_Silent_p.F64F	NM_176877.2	NP_795352	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	1391					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						AAGTCTCCTTCAGTTCACAAG	0.388000													44	38					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220334073	220334073	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr2:220334073G>C	ENST00000312358.7	+	13	3819	c.3687G>C	c.(3685-3687)caG>caC	p.Q1229H	SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	1229	Ig-like 6.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		ACCGCATCCAGAGCAGCGACG	0.642000													10	22					0	0	1	0	0
PPP2R2C	5522	broad.mit.edu	37	4	6380209	6380209	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr4:6380209C>T	ENST00000335585.5	-	3	282	c.259G>A	c.(259-261)Gag>Aag	p.E87K	PPP2R2C_ENST00000515571.1_Missense_Mutation_p.E70K|PPP2R2C_ENST00000314348.8_Intron|PPP2R2C_ENST00000506140.1_Missense_Mutation_p.E80K|PPP2R2C_ENST00000382599.4_Missense_Mutation_p.E87K|PPP2R2C_ENST00000507294.1_Missense_Mutation_p.E80K	NM_181876.2	NP_870991.1	Q9Y2T4	2ABG_HUMAN	protein phosphatase 2, regulatory subunit B, gamma	87					signal transduction	protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	28						TCCTCTATCTCCAGGCTCTTG	0.577000													31	125					0	0	1	0	0
TIMD4	91937	broad.mit.edu	37	5	156375475	156375475	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr5:156375475C>T	ENST00000274532.2	-	5	852	c.796G>A	c.(796-798)Gtg>Atg	p.V266M	TIMD4_ENST00000407087.3_Intron	NM_138379.2	NP_612388.2	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain containing 4	266	Ser-rich.					integral to membrane				NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(23)|ovary(2)|skin(2)	37	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CACATTGACACGTGGGATGTT	0.373000													8	15					0	0	1	0	0
ZNF461	92283	broad.mit.edu	37	19	37129879	37129879	+	Silent	SNP	G	G	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr19:37129879G>C	ENST00000588268.1	-	6	1595	c.1368C>G	c.(1366-1368)ctC>ctG	p.L456L	ZNF461_ENST00000360357.4_Silent_p.L433L|ZNF461_ENST00000540605.2_5'UTR	NM_153257.2	NP_694989.2	Q8TAF7	ZN461_HUMAN	zinc finger protein 461	456					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|prostate(1)|urinary_tract(2)	29	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			GATGTCTTTTGAGGTGTGAAC	0.398000													26	47					0	0	1	0	0
SLC45A2	51151	broad.mit.edu	37	5	33954552	33954552	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr5:33954552G>A	ENST00000382102.3	-	4	1003	c.946C>T	c.(946-948)Cac>Tac	p.H316Y	SLC45A2_ENST00000296589.4_Missense_Mutation_p.H316Y|SLC45A2_ENST00000345083.5_Missense_Mutation_p.H208Y|SLC45A2_ENST00000509381.1_Missense_Mutation_p.S207L|SLC45A2_ENST00000342059.3_Missense_Mutation_p.H257Y	NM_001012509.2	NP_001012527	Q9UMX9	S45A2_HUMAN	solute carrier family 45, member 2	316					melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane		p.H316Y(2)		breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(25)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48						TAGCGGTAGTGAGGAGGCATG	0.478000													13	61					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49695493	49695493	+	Missense_Mutation	SNP	G	G	A	rs147846190		TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr3:49695493G>A	ENST00000296452.4	+	5	8618	c.8504G>A	c.(8503-8505)cGc>cAc	p.R2835H		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	2835					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		AGCGCTCTCCGCCAGCAGACG	0.622000													76	42					0	0	1	0	0
MAP3K12	7786	broad.mit.edu	37	12	53875051	53875051	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr12:53875051G>C	ENST00000267079.2	-	15	2720	c.2495C>G	c.(2494-2496)tCt>tGt	p.S832C	MAP3K12_ENST00000547035.1_Missense_Mutation_p.S865C|MAP3K12_ENST00000547488.1_Missense_Mutation_p.S865C	NM_001193511.1|NM_006301.3	NP_001180440.1|NP_006292.3	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase 12	832					histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(2)|breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	37						TGAGTCCTCAGAATTGGGAGG	0.498000													3	15					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190423875	190423875	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr1:190423875G>C	ENST00000367462.3	-	2	377	c.146C>G	c.(145-147)tCt>tGt	p.S49C	BRINP3_ENST00000534846.1_Missense_Mutation_p.L11V	NM_199051.1	NP_950252.1			bone morphogenetic protein/retinoic acid inducible neural-specific 3	49																	TCCCTTATCAGAGAGGAGCCA	0.498000													19	37					0	0	1	0	0
SPATS1	221409	broad.mit.edu	37	6	44329600	44329600	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr6:44329600C>T	ENST00000288390.2	+	4	792	c.445C>T	c.(445-447)Cca>Tca	p.P149S	RP11-444E17.6_ENST00000505802.1_3'UTR|SPATS1_ENST00000323108.8_Missense_Mutation_p.P149S			Q496A3	SPAS1_HUMAN	spermatogenesis associated, serine-rich 1	149										NS(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(2)|lung(5)|skin(1)|urinary_tract(1)	14	all_lung(25;0.00469)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GACATTTTACCCAAGGTTTAG	0.478000													51	127					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33290975	33290975	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr14:33290975T>C	ENST00000280979.4	+	13	4126	c.3956T>C	c.(3955-3957)gTt>gCt	p.V1319A	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1319					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		CAGCCTAATGTTTTAACTAAG	0.418000													4	44					0	0	1	0	0
TAS2R46	259292	broad.mit.edu	37	12	11214588	11214588	+	Silent	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr12:11214588G>A	ENST00000533467.1	-	1	305	c.306C>T	c.(304-306)ctC>ctT	p.L102L	TAS2R14_ENST00000381852.4_Intron|PRR4_ENST00000536668.1_Intron	NM_176887.2	NP_795368.2	P59540	T2R46_HUMAN	taste receptor, type 2, member 46	102					sensory perception of taste	cilium membrane|integral to membrane	G-protein coupled receptor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(49;0.0344)	BRCA - Breast invasive adenocarcinoma(232;0.196)		AAAATATGCTGAGGCTAGTAG	0.383000													75	68					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	141010092	141010092	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr9:141010092G>A	ENST00000277549.5	+	42	5889	c.3320G>A	c.(3319-3321)cGa>cAa	p.R1107Q	CACNA1B_ENST00000371363.1_Missense_Mutation_p.R1911Q|CACNA1B_ENST00000371357.1_Missense_Mutation_p.R1912Q|CACNA1B_ENST00000371355.4_Missense_Mutation_p.R1914Q|CACNA1B_ENST00000371372.1_Missense_Mutation_p.R1913Q|CACNA1B_ENST00000277551.2_Missense_Mutation_p.R1913Q			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1913					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	GTTTTCCTTCGACAGAAGAGT	0.592000													30	61					0	0	1	0	0
PDE4C	5143	broad.mit.edu	37	19	18327678	18327678	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr19:18327678T>A	ENST00000355502.3	-	16	2229	c.1358A>T	c.(1357-1359)gAc>gTc	p.D453V	PDE4C_ENST00000597297.1_Missense_Mutation_p.D223V|PDE4C_ENST00000262805.12_Missense_Mutation_p.D421V|PDE4C_ENST00000594617.3_Missense_Mutation_p.D453V|AC068499.10_ENST00000594805.3_RNA|PDE4C_ENST00000598111.2_Missense_Mutation_p.D168V|PDE4C_ENST00000539010.1_Missense_Mutation_p.D222V|PDE4C_ENST00000447275.3_Missense_Mutation_p.D347V|PDE4C_ENST00000594465.3_Missense_Mutation_p.D453V			Q08493	PDE4C_HUMAN	phosphodiesterase 4C, cAMP-specific	453					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	33					Dyphylline(DB00651)	CACCGAGGCGTCGTTGTACAT	0.577000													27	91					0	0	1	0	0
LMTK2	22853	broad.mit.edu	37	7	97822764	97822764	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr7:97822764C>G	ENST00000297293.5	+	11	3280	c.2987C>G	c.(2986-2988)aCc>aGc	p.T996S		NM_014916.3	NP_055731.2	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2	996					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|pancreas(2)|skin(2)|stomach(3)	59	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					TCCCTGGAAACCCCGGACTCT	0.602000													40	187					0	0	1	0	0
MYO5A	4644	broad.mit.edu	37	15	52656895	52656895	+	Silent	SNP	A	A	G			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr15:52656895A>G	ENST00000399231.3	-	24	3408	c.3165T>C	c.(3163-3165)acT>acC	p.T1055T	MYO5A_ENST00000399233.2_Silent_p.T1055T|MYO5A_ENST00000358212.6_Silent_p.T1055T|MYO5A_ENST00000553916.1_Silent_p.T1055T|MYO5A_ENST00000356338.6_Silent_p.T1055T	NM_000259.3	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA (heavy chain 12, myoxin)	1055					actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		TCTTCTCCATAGTTTCTGAAA	0.378000													35	42					0	0	1	0	0
ZBTB4	57659	broad.mit.edu	37	17	7365908	7365908	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr17:7365908G>C	ENST00000311403.4	-	4	2732	c.2393C>G	c.(2392-2394)cCt>cGt	p.P798R	ZBTB4_ENST00000380599.4_Missense_Mutation_p.P798R	NM_020899.3	NP_065950.2	Q9P1Z0	ZBTB4_HUMAN	zinc finger and BTB domain containing 4	798					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(3)|skin(6)	36		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;4.1e-06)|READ - Rectum adenocarcinoma(115;0.0642)		GGCAATGACAGGGGTTGGGGT	0.662000													21	117					0	0	1	0	0
HSPA2	3306	broad.mit.edu	37	14	65007942	65007942	+	Silent	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr14:65007942C>T	ENST00000247207.6	+	1	757	c.375C>T	c.(373-375)ctC>ctT	p.L125L	HSPA2_ENST00000394709.1_Silent_p.L125L|HSPA2_ENST00000554883.1_Intron	NM_021979.3	NP_068814.2	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	125					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			breast(1)|endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	22				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		CCATGGTCCTCACGAAGATGA	0.597000													16	31					0	0	1	0	0
C10orf90	118611	broad.mit.edu	37	10	128193313	128193313	+	Silent	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr10:128193313G>A	ENST00000284694.7	-	3	576	c.456C>T	c.(454-456)cgC>cgT	p.R152R	C10orf90_ENST00000454341.1_Silent_p.R152R|C10orf90_ENST00000368674.1_5'UTR|C10orf90_ENST00000392694.1_Silent_p.R105R|C10orf90_ENST00000356858.3_Silent_p.R105R|C10orf90_ENST00000544758.1_Silent_p.R249R	NM_001004298.2	NP_001004298.2	Q96M02	CJ090_HUMAN	chromosome 10 open reading frame 90	152								p.R152R(2)		NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(19)|liver(1)|lung(29)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	65		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)		ACACCAGGGCGCGGGCTGGGG	0.697000											OREG0020616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	57					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345756	33345756	+	Silent	SNP	T	T	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr20:33345756T>C	ENST00000374796.2	-	8	3365	c.795A>G	c.(793-795)caA>caG	p.Q265Q	NCOA6_ENST00000359003.2_Silent_p.Q265Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	265	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q265Q(1)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gttgttgttgttgctgctgct	0.537000													5	78					0	0	1	0	0
TRIM28	10155	broad.mit.edu	37	19	59059228	59059228	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr19:59059228G>A	ENST00000253024.5	+	6	1198	c.909G>A	c.(907-909)atG>atA	p.M303I	TRIM28_ENST00000341753.6_Missense_Mutation_p.M221I	NM_005762.2	NP_005753.1	Q13263	TIF1B_HUMAN	tripartite motif containing 28	303	Leucine zipper alpha helical coiled-coil region.|RBCC domain.				epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent	nucleoplasm	chromo shadow domain binding|ligase activity|transcription corepressor activity|zinc ion binding			biliary_tract(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|urinary_tract(1)	19		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		TGCAGATCATGAAGGAGCTGA	0.567000													49	48					0	0	1	0	0
COPB2	9276	broad.mit.edu	37	3	139081296	139081296	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr3:139081296G>A	ENST00000333188.5	-	16	2129	c.1948C>T	c.(1948-1950)Cag>Tag	p.Q650*	COPB2_ENST00000507777.1_Nonsense_Mutation_p.Q621*	NM_004766.2	NP_004757.1	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta prime)	650					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	24						TCTCCAAGCTGAAGAGCAAGC	0.358000													5	31					0	0	1	0	0
IER5	51278	broad.mit.edu	37	1	181058345	181058345	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr1:181058345G>A	ENST00000367577.4	+	1	708	c.307G>A	c.(307-309)Gag>Aag	p.E103K		NM_016545.4	NP_057629.2	Q5VY09	IER5_HUMAN	immediate early response 5	103										lung(1)|ovary(1)|pancreas(1)|urinary_tract(1)	4						GCCGCAGCCGGAGCGCTCCTC	0.776000													4	12					0	0	1	0	0
GRSF1	2926	broad.mit.edu	37	4	71693748	71693748	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr4:71693748A>G	ENST00000254799.6	-	6	1073	c.956T>C	c.(955-957)aTc>aCc	p.I319T	GRSF1_ENST00000502323.1_Missense_Mutation_p.I157T|GRSF1_ENST00000439371.1_Missense_Mutation_p.I157T|GRSF1_ENST00000508091.1_Intron|GRSF1_ENST00000545193.1_Missense_Mutation_p.I201T	NM_002092.3	NP_002083	Q12849	GRSF1_HUMAN	G-rich RNA sequence binding factor 1	319	RRM 2.				mRNA polyadenylation		mRNA binding|nucleotide binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|upper_aerodigestive_tract(2)	17		all_hematologic(202;0.21)	Lung(101;0.235)			AAATATCTCGATGTATCTATG	0.328000													13	37					0	0	1	0	0
TRAV30	28652	broad.mit.edu	37	14	22636742	22636742	+	RNA	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr14:22636742C>T	ENST00000557168.1	+	0	195																											CACCCGTCTTCCTGATGATAT	0.453000													20	33					0	0	1	0	0
ZNF518A	9849	broad.mit.edu	37	10	97918151	97918151	+	RNA	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr10:97918151C>T	ENST00000534948.1	+	0	2929							Q6AHZ1	Z518A_HUMAN	zinc finger protein 518A						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	24		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		CAGGAGAGCTCAAAACCAGAT	0.338000													17	28					0	0	1	0	0
GPR75	10936	broad.mit.edu	37	2	54081652	54081652	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr2:54081652A>G	ENST00000394705.2	-	2	512	c.242T>C	c.(241-243)tTc>tCc	p.F81S	ASB3_ENST00000498475.2_Intron|ASB3_ENST00000406625.2_Intron|GPR75-ASB3_ENST00000352846.3_Intron	NM_006794.3	NP_006785.1	O95800	GPR75_HUMAN	G protein-coupled receptor 75	81	Phe-rich.					integral to plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	18			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			CAGGATCATGAAATCAAAGTT	0.473000													45	41					0	0	1	0	0
IQCK	124152	broad.mit.edu	37	16	19746716	19746716	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr16:19746716C>A	ENST00000320394.6	+	5	1117	c.418C>A	c.(418-420)Ctg>Atg	p.L140M	IQCK_ENST00000564186.1_Missense_Mutation_p.L140M|IQCK_ENST00000541926.1_Missense_Mutation_p.L140M|IQCK_ENST00000433597.2_Missense_Mutation_p.L52M	NM_153208.1	NP_694940.1	Q8N0W5	IQCK_HUMAN	IQ motif containing K	140										kidney(1)|large_intestine(2)|lung(2)|skin(1)	6						CTTTCCTGTTCTGCTTCCCGG	0.423000													16	53					7.07596e-05	7.207e-05	1	1	0
PNLDC1	154197	broad.mit.edu	37	6	160240056	160240056	+	Missense_Mutation	SNP	G	G	A	rs145458684		TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr6:160240056G>A	ENST00000610273.1	+	17	1474	c.1303G>A	c.(1303-1305)Gag>Aag	p.E435K	PNLDC1_ENST00000392167.3_Missense_Mutation_p.E446K	NM_001271862.1|NM_173516.1	NP_001258791.1|NP_775787.1	Q8NA58	PNDC1_HUMAN	poly(A)-specific ribonuclease (PARN)-like domain containing 1							integral to membrane|nucleus	nucleic acid binding	p.E435K(1)		autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(9)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	31		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;1.55e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		TGGGGTCAGCGAGCAGCAAGT	0.458000													71	51					0	0	1	0	0
PIWIL1	9271	broad.mit.edu	37	12	130839086	130839086	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr12:130839086A>C	ENST00000245255.3	+	10	1321	c.1049A>C	c.(1048-1050)tAc>tCc	p.Y350S		NM_001190971.1|NM_004764.4	NP_001177900.1|NP_004755.2	Q96J94	PIWL1_HUMAN	piwi-like RNA-mediated gene silencing 1	350	PAZ.				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		GAGCAGCAATACAACCAAGAG	0.522000													6	216					0	0	1	0	0
KCNT1	57582	broad.mit.edu	37	9	138676432	138676432	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr9:138676432G>C	ENST00000298480.5	+	26	3069	c.2995G>C	c.(2995-2997)Gac>Cac	p.D999H	KCNT1_ENST00000491806.2_Missense_Mutation_p.D966H|KCNT1_ENST00000487664.1_Missense_Mutation_p.D954H|KCNT1_ENST00000371757.2_Missense_Mutation_p.D999H|KCNT1_ENST00000263604.3_Missense_Mutation_p.D980H|KCNT1_ENST00000486577.2_Missense_Mutation_p.D958H|KCNT1_ENST00000490355.2_Missense_Mutation_p.D978H|KCNT1_ENST00000488444.2_Missense_Mutation_p.D980H			B7ZVY4	B7ZVY4_HUMAN	potassium channel, subfamily T, member 1	999						membrane	binding|calcium-activated potassium channel activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		GCTGGGCCTGGACACCACGCC	0.692000													18	6					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95480633	95480633	+	RNA	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr2:95480633G>A	ENST00000432432.2	-	0	2727					NR_040113.1																						ccagccccttgcaaacattaa	0.388000													4	11					0	0	1	0	0
ZNF627	199692	broad.mit.edu	37	19	11728072	11728072	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr19:11728072G>C	ENST00000361113.5	+	4	962	c.754G>C	c.(754-756)Gaa>Caa	p.E252Q	ZNF627_ENST00000588174.1_3'UTR	NM_145295.3	NP_660338.1	Q7L945	ZN627_HUMAN	zinc finger protein 627	252					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	14						TAAACCCTATGAATGCAAGCA	0.428000													13	54					0	0	1	0	0
ZNF638	27332	broad.mit.edu	37	2	71650620	71650620	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr2:71650620A>G	ENST00000409544.1	+	22	4606	c.3976A>G	c.(3976-3978)Ata>Gta	p.I1326V	ZNF638_ENST00000355812.3_Intron|ZNF638_ENST00000409407.1_Missense_Mutation_p.I266V|ZNF638_ENST00000264447.4_Missense_Mutation_p.I1326V	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	1326	Glu-rich.				RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						GGATCTTCAAATAGGAACAGA	0.363000													12	63					0	0	1	0	0
ORC5	5001	broad.mit.edu	37	7	103841286	103841286	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr7:103841286A>T	ENST00000297431.4	-	3	428	c.286T>A	c.(286-288)Tgt>Agt	p.C96S	ORC5_ENST00000545943.1_5'UTR|ORC5_ENST00000485726.1_5'UTR|ORC5_ENST00000447452.2_Missense_Mutation_p.C96S	NM_002553.3	NP_002544.1	O43913	ORC5_HUMAN	origin recognition complex, subunit 5	96					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	cytoplasm|nuclear origin of replication recognition complex|nucleoplasm	ATP binding|DNA replication origin binding|identical protein binding			kidney(1)|large_intestine(2)|lung(9)|pancreas(1)|upper_aerodigestive_tract(1)	14						AATGTTTCACAGGTTATTTCA	0.303000													16	14					0	0	1	0	0
WARS	7453	broad.mit.edu	37	14	100803431	100803431	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr14:100803431C>T	ENST00000355338.2	-	10	1840	c.1222G>A	c.(1222-1224)Gag>Aag	p.E408K	WARS_ENST00000557135.1_Missense_Mutation_p.E408K|WARS_ENST00000344102.5_Missense_Mutation_p.E367K|WARS_ENST00000556645.1_Missense_Mutation_p.E367K|WARS_ENST00000358655.4_Missense_Mutation_p.E367K|RP11-638I2.8_ENST00000557226.1_RNA|WARS_ENST00000392882.2_Missense_Mutation_p.E408K	NM_173701.1	NP_776049.1	P23381	SYWC_HUMAN	tryptophanyl-tRNA synthetase	408					angiogenesis|negative regulation of cell proliferation|regulation of angiogenesis|tryptophanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|protein binding|tryptophan-tRNA ligase activity			breast(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	20		all_cancers(154;0.00223)|all_lung(585;2.48e-06)|all_epithelial(191;0.000564)|Melanoma(154;0.152)			L-Tryptophan(DB00150)	TCGTCGTCCTCGAGGAAGAAG	0.597000													75	185					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	118982272	118982272	+	Silent	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr9:118982272C>T	ENST00000328252.3	+	5	2344	c.1975C>T	c.(1975-1977)Ctg>Ttg	p.L659L	PAPPA_ENST00000534838.1_Intron	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	659					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						GCACTGTTACCTGGACCTGGT	0.597000													86	67					0	0	1	0	0
MFSD5	84975	broad.mit.edu	37	12	53646949	53646949	+	Silent	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr12:53646949C>T	ENST00000534842.1	+	2	798	c.651C>T	c.(649-651)ctC>ctT	p.L217L	MFSD5_ENST00000329548.4_Silent_p.L110L	NM_001170790.1	NP_001164261.1	Q6N075	MFSD5_HUMAN	major facilitator superfamily domain containing 5	110					transport	integral to membrane				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|skin(3)|urinary_tract(1)	16						CTTGTGTCCTCTTCTCCCTGA	0.537000													113	266					0	0	1	0	0
SUPT7L	9913	broad.mit.edu	37	2	27880452	27880452	+	Silent	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr2:27880452G>A	ENST00000337768.5	-	4	1073	c.504C>T	c.(502-504)caC>caT	p.H168H	SUPT7L_ENST00000406540.1_Silent_p.H166H|SUPT7L_ENST00000464789.2_Silent_p.H166H|SUPT7L_ENST00000405491.1_Silent_p.H166H|SUPT7L_ENST00000404798.2_Silent_p.H33H	NM_001282729.1|NM_014860.1	NP_001269658.1|NP_055675.1	O94864	ST65G_HUMAN	suppressor of Ty 7 (S. cerevisiae)-like	168					histone H3 acetylation|maintenance of protein location in nucleus|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|prostate(2)|skin(2)|urinary_tract(1)	16	Acute lymphoblastic leukemia(172;0.155)					CAAAGCCCGCGTGGGCCAGGA	0.537000													32	39					0	0	1	0	0
RRN3	54700	broad.mit.edu	37	16	15155703	15155703	+	Silent	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr16:15155703G>A	ENST00000198767.6	-	18	1937	c.1854C>T	c.(1852-1854)acC>acT	p.T618T	RRN3_ENST00000540462.1_Silent_p.T436T|RRN3_ENST00000327307.7_Silent_p.T585T|RRN3_ENST00000563559.1_Silent_p.T618T|PDXDC1_ENST00000535621.2_Intron|RRN3_ENST00000429751.2_Silent_p.T588T	NM_018427.3	NP_060897.3	Q9NYV6	RRN3_HUMAN	RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)	618	Interaction with EIF3L.|Interaction with TWISTNB.				regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm				NS(2)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)	20						TCCCAATCACGGTATCATTCT	0.488000													12	38					0	0	1	0	0
UGGT2	55757	broad.mit.edu	37	13	96637534	96637534	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr13:96637534C>G	ENST00000397618.3	-	10	1176	c.1089G>C	c.(1087-1089)ttG>ttC	p.L363F	UGGT2_ENST00000467305.1_5'UTR|UGGT2_ENST00000376747.3_Intron|UGGT2_ENST00000376714.3_Intron			Q9NYU1	UGGG2_HUMAN	UDP-glucose glycoprotein glucosyltransferase 2	1236					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(17)|lung(20)|ovary(3)|pancreas(1)|prostate(4)|urinary_tract(2)	60						GACGACTTCTCAAATTCTTGA	0.269000													5	16					0	0	1	0	0
LGALS13	29124	broad.mit.edu	37	19	40095307	40095307	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr19:40095307C>G	ENST00000221797.4	+	2	126	c.81C>G	c.(79-81)atC>atG	p.I27M		NM_013268.2	NP_037400.1	Q9UHV8	PP13_HUMAN	lectin, galactoside-binding, soluble, 13	27	Galectin.				lipid catabolic process|phospholipid metabolic process		carboxylesterase activity|lysophospholipase activity|sugar binding			lung(5)|ovary(1)|urinary_tract(1)	7	all_cancers(60;1.77e-05)|all_lung(34;5.38e-08)|Lung NSC(34;6.37e-08)|Ovarian(47;0.116)		Epithelial(26;3.28e-26)|OV - Ovarian serous cystadenocarcinoma(5;7.31e-25)|all cancers(26;1.15e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			GGACACCAATCCACTCTTTTA	0.463000													31	83					0	0	1	0	0
TM9SF4	9777	broad.mit.edu	37	20	30746281	30746281	+	Silent	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr20:30746281C>T	ENST00000217315.5	+	15	1822	c.1482C>T	c.(1480-1482)ttC>ttT	p.F494F	TM9SF4_ENST00000398022.2_Silent_p.F511F			Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	511						integral to membrane		p.F494F(1)		central_nervous_system(2)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TCTTGCCCTTCGGCGCCATGT	0.592000													65	67					0	0	1	0	0
ANO5	203859	broad.mit.edu	37	11	22283797	22283797	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr11:22283797T>G	ENST00000324559.8	+	16	2070	c.1753T>G	c.(1753-1755)Tat>Gat	p.Y585D	CTD-3064C13.1_ENST00000526935.1_RNA	NM_001142649.1|NM_213599.2	NP_001136121.1|NP_998764.1	Q75V66	ANO5_HUMAN	anoctamin 5	585						chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(12)|lung(36)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GTTCGTAGGCTATCCTGGAAA	0.363000													13	73					0	0	1	0	0
SMAD6	4091	broad.mit.edu	37	15	67073705	67073705	+	Silent	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr15:67073705C>T	ENST00000288840.5	+	4	2354	c.1323C>T	c.(1321-1323)ttC>ttT	p.F441F	SMAD6_ENST00000338426.4_Silent_p.F180F	NM_005585.4	NP_005576.3	O43541	SMAD6_HUMAN	SMAD family member 6	441	MH2.				BMP signaling pathway|immune response|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of caspase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of SMAD protein complex assembly|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of S phase of mitotic cell cycle|response to laminar fluid shear stress|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	cytosol|transcription factor complex	co-SMAD binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|type I activin receptor binding|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			lung(1)|skin(1)	2						TGTTCGACTTCGAGCGCTCGG	0.726000													32	37					0	0	1	0	0
KPNA2	3838	broad.mit.edu	37	17	66038302	66038302	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr17:66038302C>A	ENST00000537025.2	+	5	1024	c.404C>A	c.(403-405)cCc>cAc	p.P135H	KPNA2_ENST00000330459.3_Missense_Mutation_p.P135H			P52292	IMA2_HUMAN	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	135					DNA metabolic process|G2 phase of mitotic cell cycle|interspecies interaction between organisms|M phase specific microtubule process|NLS-bearing substrate import into nucleus|regulation of DNA recombination	cytoplasm|nuclear pore|nucleoplasm	histone deacetylase binding|nuclear localization sequence binding|protein transporter activity			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|kidney(2)|lung(9)|prostate(1)|urinary_tract(2)	22	all_cancers(12;1.18e-09)		BRCA - Breast invasive adenocarcinoma(8;1.03e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			GATTGTAGTCCCATTCAGTTT	0.458000													32	193					2.85442e-18	3.13986e-18	1	1	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S165S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								4	63					0	0	1	0	0
IGKV1-17	28937	broad.mit.edu	37	2	89417306	89417306	+	RNA	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr2:89417306C>T	ENST00000490686.1	-	0	29																											CCCTCATGTCCATGCTGTGTC	0.547000													5	277					0	0	1	0	0
TCFL5	10732	broad.mit.edu	37	20	61488812	61488812	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr20:61488812C>G	ENST00000335351.3	-	4	1265	c.1173G>C	c.(1171-1173)caG>caC	p.Q391H	TCFL5_ENST00000217162.5_Missense_Mutation_p.Q343H	NM_006602.2	NP_006593.2	Q9UL49	TCFL5_HUMAN	transcription factor-like 5 (basic helix-loop-helix)	391					cell differentiation|multicellular organismal development|regulation of cell differentiation|regulation of cell proliferation|spermatogenesis|transcription from RNA polymerase II promoter		DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(1)|urinary_tract(1)	9	Breast(26;5.68e-08)					GGGGCCCACTCTGGGCCTGCT	0.572000													71	99					0	0	1	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140745833	140745833	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr5:140745833G>T	ENST00000518069.1	+	1	1936	c.1936G>T	c.(1936-1938)Gtc>Ttc	p.V646F	PCDHGB2_ENST00000522605.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018918.2|NM_032054.1	NP_061741.1|NP_114443.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|upper_aerodigestive_tract(3)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGGTGGCCGTCGAAGACCA	0.652000													5	233					0.014758	0.0148254	1	1	0
KCNH3	23416	broad.mit.edu	37	12	49951242	49951242	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr12:49951242C>T	ENST00000257981.6	+	15	3018	c.2758C>T	c.(2758-2760)Cgg>Tgg	p.R920W		NM_012284.1	NP_036416.1	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 3	920					regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36						TCCGTGCCCTCGGGCATCGGG	0.677000													4	28					0	0	1	0	0
IQGAP1	8826	broad.mit.edu	37	15	91021105	91021105	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr15:91021105C>T	ENST00000268182.5	+	26	3437	c.3313C>T	c.(3313-3315)Cag>Tag	p.Q1105*	IQGAP1_ENST00000560738.1_Nonsense_Mutation_p.Q533*	NM_003870.3	NP_003861.1	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	1105	C1.|Ras-GAP.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			GATGGAGTCTCAGACAGGAGA	0.373000													41	57					0	0	1	0	0
PCDHGB2	56103	broad.mit.edu	37	5	140739726	140739726	+	Silent	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr5:140739726C>T	ENST00000522605.1	+	1	24	c.24C>T	c.(22-24)tgC>tgT	p.C8C	PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018923.2|NM_032096.1	NP_061746.1|NP_115267.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGGGAGGTGCGGGCTGGTGC	0.582000											OREG0016857	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	9					0	0	1	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140745832	140745832	+	Silent	SNP	C	C	G			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr5:140745832C>G	ENST00000518069.1	+	1	1935	c.1935C>G	c.(1933-1935)gcC>gcG	p.A645A	PCDHGB2_ENST00000522605.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018918.2|NM_032054.1	NP_061741.1|NP_114443.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|upper_aerodigestive_tract(3)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGTGGTGGCCGTCGAAGACC	0.657000													5	233					0	0	1	0	0
PRKRA	8575	broad.mit.edu	37	2	179296957	179296957	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr2:179296957T>A	ENST00000325748.4	-	8	1009	c.809A>T	c.(808-810)tAt>tTt	p.Y270F	PRKRA_ENST00000432031.2_Missense_Mutation_p.Y259F|PRKRA_ENST00000438687.3_Missense_Mutation_p.Y157F|AC009948.5_ENST00000453026.2_RNA|PRKRA_ENST00000487082.1_Missense_Mutation_p.Y245F|AC009948.5_ENST00000415236.1_RNA|AC009948.5_ENST00000454488.1_RNA|AC009948.5_ENST00000436616.2_RNA	NM_003690.4	NP_003681.1	O75569	PRKRA_HUMAN	protein kinase, interferon-inducible double stranded RNA dependent activator	270	DRBM 3.|Sufficient for self-association and interaction with TARBP2.				immune response|negative regulation of cell proliferation|production of siRNA involved in RNA interference|response to virus	perinuclear region of cytoplasm	double-stranded RNA binding|enzyme activator activity|protein homodimerization activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|skin(2)	19			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.00634)|all cancers(119;0.0265)			AAGACATTGATATTGTCCATT	0.428000													6	63					0	0	1	0	0
RTN4RL2	349667	broad.mit.edu	37	11	57243854	57243854	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr11:57243854G>A	ENST00000335099.3	+	3	1050	c.733G>A	c.(733-735)Gag>Aag	p.E245K		NM_178570.1	NP_848665.1	Q86UN3	R4RL2_HUMAN	reticulon 4 receptor-like 2	245					axon regeneration	anchored to plasma membrane	receptor activity			NS(1)|endometrium(1)|large_intestine(2)|lung(2)	6						GCTGCCCGGCGAGGCGCTCGC	0.731000													7	25					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228473993	228473993	+	Silent	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr1:228473993G>A	ENST00000570156.2	+	39	10580	c.10506G>A	c.(10504-10506)tcG>tcA	p.S3502S	OBSCN_ENST00000359599.6_Silent_p.S1920S|OBSCN_ENST00000422127.1_Silent_p.S3073S|OBSCN_ENST00000366707.4_Silent_p.S192S|OBSCN_ENST00000366709.4_Silent_p.S192S|OBSCN_ENST00000284548.11_Silent_p.S3073S	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	2535	Ig-like 35.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TCAAGGACTCGGGCACCATCT	0.647000													3	14					0	0	1	0	0
FAM13B	51306	broad.mit.edu	37	5	137354722	137354722	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr5:137354722C>T	ENST00000033079.3	-	3	530	c.79G>A	c.(79-81)Gag>Aag	p.E27K	FAM13B_ENST00000425075.2_Intron|FAM13B_ENST00000420893.2_Missense_Mutation_p.E27K	NM_016603.2	NP_057687.2	Q9NYF5	FA13B_HUMAN	family with sequence similarity 13, member B	27	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			endometrium(4)|kidney(2)|lung(5)	11						TGCTGCAGCTCATCAAGTGGA	0.438000													55	28					0	0	1	0	0
ZXDB	158586	broad.mit.edu	37	X	57619097	57619097	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chrX:57619097G>A	ENST00000374888.1	+	1	829	c.616G>A	c.(616-618)Ggg>Agg	p.G206R		NM_007157.3	NP_009088.1	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	206					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding	p.G206R(2)		NS(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(2)|skin(6)	27						CCAGCAGCCCGGGTGTCTGAT	0.711000													4	22					0	0	1	0	0
TRAF5	7188	broad.mit.edu	37	1	211533413	211533413	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr1:211533413C>A	ENST00000261464.5	+	5	592	c.538C>A	c.(538-540)Cta>Ata	p.L180I	TRAF5_ENST00000427925.2_Intron|TRAF5_ENST00000336184.2_Missense_Mutation_p.L180I|TRAF5_ENST00000462410.1_3'UTR|TRAF5_ENST00000367004.3_Missense_Mutation_p.L180I	NM_001033910.2	NP_001029082.1	O00463	TRAF5_HUMAN	TNF receptor-associated factor 5	180					apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis	CD40 receptor complex|centrosome|internal side of plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				OV - Ovarian serous cystadenocarcinoma(81;0.00946)|all cancers(67;0.0808)|Epithelial(68;0.144)		AGTCATCAATCTACAGGTGAA	0.418000													28	28					1.50538e-07	1.58461e-07	1	1	0
TRBV7-7	28591	broad.mit.edu	37	7	142120047	142120047	+	RNA	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr7:142120047G>A	ENST00000390377.1	-	0	119																											GATCACACCTGAGAGTTACAT	0.478000													16	52					0	0	1	0	0
ANKHD1	54882	broad.mit.edu	37	5	139905607	139905607	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr5:139905607C>T	ENST00000297183.6	+	26	4643	c.4519C>T	c.(4519-4521)Cct>Tct	p.P1507S	ANKHD1-EIF4EBP3_ENST00000532219.1_Missense_Mutation_p.P1507S|ANKHD1_ENST00000360839.2_Missense_Mutation_p.P1507S	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATAGAACCTCCTAGTGCAAC	0.388000													24	87					0	0	1	0	0
ROCK2	9475	broad.mit.edu	37	2	11332352	11332352	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr2:11332352G>C	ENST00000315872.6	-	32	4533	c.4085C>G	c.(4084-4086)tCt>tGt	p.S1362C	ROCK2_ENST00000401753.1_Missense_Mutation_p.S1119C	NM_004850.3	NP_004841.2	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein kinase 2	1362					axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(6)|lung(10)|prostate(1)|skin(4)|stomach(3)|urinary_tract(2)	43	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		AGTTCTAGGAGATGATCGGGC	0.433000													54	190					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	145075751	145075751	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr1:145075751G>A	ENST00000369359.4	-	1	150	c.112C>T	c.(112-114)Cga>Tga	p.R38*	PDE4DIP_ENST00000369345.4_Nonsense_Mutation_p.R38*|PDE4DIP_ENST00000530740.1_Nonsense_Mutation_p.R38*|PDE4DIP_ENST00000369348.3_Nonsense_Mutation_p.R38*			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TGAGGGGTTCGCGTCGCGTCC	0.726000			T	PDGFRB	MPD								8	157					0	0	1	0	0
HUS1B	135458	broad.mit.edu	37	6	656428	656428	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr6:656428C>T	ENST00000380907.2	-	1	535	c.517G>A	c.(517-519)Gcg>Acg	p.A173T	EXOC2_ENST00000448181.3_Intron|EXOC2_ENST00000230449.4_Intron	NM_148959.3	NP_683762.2	Q8NHY5	HUS1B_HUMAN	HUS1 checkpoint homolog b (S. pombe)	173										endometrium(3)|large_intestine(1)|lung(7)	11	Ovarian(93;0.0733)	Breast(5;0.00139)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.041)|BRCA - Breast invasive adenocarcinoma(62;0.0965)		CCCACGTTCGCCATCCTCTCC	0.607000													15	130					0	0	1	0	0
TARS	6897	broad.mit.edu	37	5	33459922	33459922	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr5:33459922G>C	ENST00000265112.3	+	11	1517	c.1206G>C	c.(1204-1206)gaG>gaC	p.E402D	TARS_ENST00000455217.2_Missense_Mutation_p.E435D|TARS_ENST00000414361.2_Missense_Mutation_p.E281D|TARS_ENST00000541634.1_Missense_Mutation_p.E298D|TARS_ENST00000502553.1_Missense_Mutation_p.E402D	NM_152295.4	NP_689508.3	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	402					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity			NS(1)|biliary_tract(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)	29					L-Threonine(DB00156)	TTGAGGTGGAGAAGGAGCTGT	0.502000													30	116					0	0	1	0	0
MEPE	56955	broad.mit.edu	37	4	88766393	88766393	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr4:88766393G>A	ENST00000497649.2	+	6	679	c.301G>A	c.(301-303)Ggg>Agg	p.G101R	MEPE_ENST00000361056.3_Missense_Mutation_p.G125R|MEPE_ENST00000540395.1_Missense_Mutation_p.G12R|MEPE_ENST00000508016.1_3'UTR|MEPE_ENST00000395102.4_Missense_Mutation_p.G156R|MEPE_ENST00000560249.1_Missense_Mutation_p.G12R|MEPE_ENST00000424957.3_Missense_Mutation_p.G125R			Q9NQ76	MEPE_HUMAN	matrix extracellular phosphoglycoprotein	125					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		TGGGAATAAAGGGTTTGAGGA	0.383000													34	56					0	0	1	0	0
WASH3P	374666	broad.mit.edu	37	15	102516480	102516480	+	RNA	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr15:102516480G>A	ENST00000557932.1	+	0	1428																				central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						GGGGCTCCATGACACCTTCCC	0.637000													4	78					0	0	1	0	0
HEATR5B	54497	broad.mit.edu	37	2	37280725	37280725	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr2:37280725C>T	ENST00000233099.5	-	17	2520	c.2425G>A	c.(2425-2427)Gaa>Aaa	p.E809K	HEATR5B_ENST00000354531.2_Missense_Mutation_p.E809K	NM_019024.1	NP_061897.1	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	809							binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|pancreas(1)|prostate(1)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	77		all_hematologic(82;0.21)				TTAACACATTCAGCAAAGTGA	0.328000													12	25					0	0	1	0	0
DLGAP1	9229	broad.mit.edu	37	18	3582034	3582034	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr18:3582034C>T	ENST00000315677.3	-	8	2399	c.1804G>A	c.(1804-1806)Gcc>Acc	p.A602T	DLGAP1_ENST00000400149.3_Missense_Mutation_p.A292T|DLGAP1_ENST00000400147.2_Missense_Mutation_p.A300T|DLGAP1_ENST00000539435.1_Missense_Mutation_p.A310T|DLGAP1_ENST00000584874.1_Missense_Mutation_p.A602T|DLGAP1_ENST00000581699.1_Missense_Mutation_p.A308T|DLGAP1_ENST00000400155.1_Missense_Mutation_p.A308T|DLGAP1_ENST00000400145.2_Missense_Mutation_p.A300T|DLGAP1_ENST00000534970.1_Missense_Mutation_p.A286T|DLGAP1_ENST00000581527.1_Missense_Mutation_p.A602T|DLGAP1_ENST00000400150.3_Missense_Mutation_p.A318T|DLGAP1_ENST00000515196.2_Missense_Mutation_p.A602T	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	602					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				GCTTCGATGGCGGCTGTCAGA	0.577000													25	46					0	0	1	0	0
ITCH	83737	broad.mit.edu	37	20	33030012	33030012	+	Splice_Site	SNP	G	G	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr20:33030012G>C	ENST00000374864.4	+	10	1082		c.e10-1		ITCH_ENST00000535650.1_Splice_Site|ITCH_ENST00000262650.6_Splice_Site	NM_001257137.1|NM_001257138.1|NM_031483.5	NP_001244066.1|NP_001244067.1|NP_113671.3	Q96J02	ITCH_HUMAN	itchy E3 ubiquitin protein ligase						apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			NS(1)|breast(9)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(13)|skin(1)|upper_aerodigestive_tract(1)	36						TTGTATTTAAGTTGGGAGCAG	0.393000													12	45					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14794015	14794015	+	Splice_Site	SNP	C	C	G			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr12:14794015C>G	ENST00000261170.3	-	18	2205		c.e18+1			NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)						intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						TTTAGATGTACCATTCCGGTC	0.478000													14	44					0	0	1	0	0
ZNF548	147694	broad.mit.edu	37	19	57911159	57911159	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr19:57911159G>A	ENST00000366197.5	+	3	1754	c.1504G>A	c.(1504-1506)Gag>Aag	p.E502K	AC003002.6_ENST00000600421.1_Intron|AC003002.6_ENST00000596400.1_Intron|AC004076.7_ENST00000597410.1_Intron|ZNF548_ENST00000336128.7_Missense_Mutation_p.E514K	NM_152909.3	NP_690873.2	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	502					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CCACAGTGAAGAGAGGCTTGT	0.418000													22	83					0	0	1	0	0
UTRN	7402	broad.mit.edu	37	6	144869906	144869906	+	Silent	SNP	G	G	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr6:144869906G>T	ENST00000367545.3	+	46	6726	c.6726G>T	c.(6724-6726)ctG>ctT	p.L2242L		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	2242					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CCGACTGGCTGGTATTAATCG	0.413000													9	23					1.12685e-05	1.16388e-05	1	1	0
CLDN14	23562	broad.mit.edu	37	21	37833622	37833622	+	Silent	SNP	G	G	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr21:37833622G>C	ENST00000399137.1	-	3	1238	c.372C>G	c.(370-372)ctC>ctG	p.L124L	CLDN14_ENST00000399139.1_Silent_p.L124L|CLDN14_ENST00000399135.1_Silent_p.L124L|AP000695.4_ENST00000428667.1_RNA|CLDN14_ENST00000342108.2_Silent_p.L124L|AP000695.6_ENST00000429588.1_RNA|CLDN14_ENST00000399136.1_Silent_p.L124L	NM_144492.2	NP_652763.1	O95500	CLD14_HUMAN	claudin 14	124					calcium-independent cell-cell adhesion|protein complex assembly|tight junction assembly	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|lung(5)|skin(1)	7						CCAGGATGAAGAGGGTGCCGC	0.657000													34	121					0	0	1	0	0
ZNF135	7694	broad.mit.edu	37	19	58578626	58578626	+	Silent	SNP	C	C	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr19:58578626C>A	ENST00000506786.1	+	5	1202	c.648C>A	c.(646-648)acC>acA	p.T216T	ZNF135_ENST00000313434.5_Silent_p.T258T|ZNF135_ENST00000511556.1_Silent_p.T270T|ZNF135_ENST00000439855.2_Silent_p.T258T|ZNF135_ENST00000401053.4_Silent_p.T282T|ZNF135_ENST00000359978.6_Silent_p.T270T			B4DHH9	B4DHH9_HUMAN	zinc finger protein 135	270					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(26)|ovary(1)|skin(1)|urinary_tract(1)	41		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		CGGCACTTACCAAACACCAGA	0.507000													48	197					2.46787e-29	2.7283e-29	1	1	0
TPCN1	53373	broad.mit.edu	37	12	113707634	113707634	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr12:113707634C>G	ENST00000550785.1	+	8	1117	c.948C>G	c.(946-948)atC>atG	p.I316M	TPCN1_ENST00000335509.6_Missense_Mutation_p.I244M|TPCN1_ENST00000392569.4_Missense_Mutation_p.I176M|TPCN1_ENST00000541517.1_Missense_Mutation_p.I316M	NM_001143819.1	NP_001137291.1	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1	244						endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(1)	40						TCTTCATGATCATCTTTGCCA	0.572000													49	77					0	0	1	0	0
LMX1B	4010	broad.mit.edu	37	9	129455523	129455523	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr9:129455523G>T	ENST00000355497.5	+	4	669	c.662G>T	c.(661-663)cGa>cTa	p.R221L	LMX1B_ENST00000373474.4_Missense_Mutation_p.R221L|LMX1B_ENST00000526117.1_Missense_Mutation_p.R221L|LMX1B_ENST00000561065.1_Missense_Mutation_p.R198L|LMX1B_ENST00000425646.2_Missense_Mutation_p.R198L	NM_001174146.1	NP_001167617.1	O60663	LMX1B_HUMAN	LIM homeobox transcription factor 1, beta	198					dorsal/ventral pattern formation|in utero embryonic development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	15						AGGCCCAAGCGACCCCGGACC	0.672000									Nail-Patella Syndrome				5	16					1.024e-07	1.08308e-07	1	1	0
TPTE2P6	374491	broad.mit.edu	37	13	25161397	25161397	+	RNA	SNP	C	C	G	rs3874227	by1000genomes	TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr13:25161397C>G	ENST00000453498.1	+	0	921				TPTE2P6_ENST00000440905.1_RNA																							TGAAACATCTCTACAACTGGA	0.343000													4	48					0	0	1	0	0
GABRG3	2567	broad.mit.edu	37	15	27271920	27271920	+	Silent	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr15:27271920C>T	ENST00000333743.6	+	3	476	c.222C>T	c.(220-222)gaC>gaT	p.D74D	GABRG3_ENST00000555083.1_Silent_p.D74D	NM_033223.4	NP_150092.2	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 3	74					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(23)|skin(1)|upper_aerodigestive_tract(4)	42		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		CCGTAATTGACGTTGACATTT	0.393000													3	23					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123207876	123207876	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr4:123207876T>C	ENST00000264501.4	+	53	9591	c.9218T>C	c.(9217-9219)aTa>aCa	p.I3073T	KIAA1109_ENST00000388738.3_Missense_Mutation_p.I3073T|KIAA1109_ENST00000455637.1_Missense_Mutation_p.I3073T			Q2LD37	K1109_HUMAN	KIAA1109	3073					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						GTGTGGAGTATAGATGAACTG	0.378000													16	57					0	0	1	0	0
ESR1	2099	broad.mit.edu	37	6	152265629	152265629	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr6:152265629C>T	ENST00000440973.1	+	6	1452	c.1082C>T	c.(1081-1083)gCg>gTg	p.A361V	ESR1_ENST00000406599.1_Intron|ESR1_ENST00000338799.5_Missense_Mutation_p.A361V|ESR1_ENST00000427531.2_Missense_Mutation_p.A188V|ESR1_ENST00000456483.2_Intron|ESR1_ENST00000443427.1_Missense_Mutation_p.A361V|ESR1_ENST00000206249.3_Missense_Mutation_p.A361V|ESR1_ENST00000482101.1_3'UTR	NM_001122742.1	NP_001116214.1	P03372	ESR1_HUMAN	estrogen receptor 1	361	Interaction with AKAP13.|Steroid-binding.				positive regulation of retinoic acid receptor signaling pathway|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	chromatin remodeling complex|cytoplasm|nucleoplasm	beta-catenin binding|enzyme binding|estrogen receptor activity|estrogen response element binding|nitric-oxide synthase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(19)|ovary(1)|prostate(2)|skin(1)	49		Ovarian(120;0.0448)	BRCA - Breast invasive adenocarcinoma(37;0.0841)	OV - Ovarian serous cystadenocarcinoma(155;4.55e-10)	Chlorotrianisene(DB00269)|Clomifene(DB00882)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Desogestrel(DB00304)|Dienestrol(DB00890)|Diethylstilbestrol(DB00255)|Dromostanolone(DB00858)|Drospirenone(DB01395)|Estradiol(DB00783)|Estramustine(DB01196)|Estriol(DB04573)|Estrone(DB00655)|Ethinyl Estradiol(DB00977)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Fluoxymesterone(DB01185)|Fulvestrant(DB00947)|Letrozole(DB01006)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Melatonin(DB01065)|Mestranol(DB01357)|Naloxone(DB01183)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)|Quinestrol(DB04575)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Toremifene(DB00539)	ATCAACTGGGCGAAGAGGGTG	0.478000													19	70					0	0	1	0	0
UGT2B17	7367	broad.mit.edu	37	4	69403562	69403562	+	Silent	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr4:69403562C>T	ENST00000317746.2	-	6	1416	c.1374G>A	c.(1372-1374)ctG>ctA	p.L458L		NM_001077.3	NP_001068.1	O75795	UDB17_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B17	458					steroid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(14)|ovary(2)|prostate(1)	30						CTGCTCGATCCAGGGGCTTCA	0.418000													98	113					0	0	1	0	0
ERBB3	2065	broad.mit.edu	37	12	56492632	56492632	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr12:56492632G>A	ENST00000267101.3	+	23	3222	c.2782G>A	c.(2782-2784)Gag>Aag	p.E928K	ERBB3_ENST00000549832.1_Missense_Mutation_p.E48K|ERBB3_ENST00000450146.2_Missense_Mutation_p.E285K|ERBB3_ENST00000553131.1_Missense_Mutation_p.E169K|ERBB3_ENST00000415288.2_Missense_Mutation_p.E869K	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	928	Protein kinase.				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			AGAGAAGGGGGAGCGGTTGGC	0.512000													28	78					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7639260	7639260	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr12:7639260C>T	ENST00000359156.4	-	10	2495	c.2293G>A	c.(2293-2295)Gcc>Acc	p.A765T	CD163_ENST00000541972.1_Missense_Mutation_p.A753T|CD163_ENST00000396620.3_Missense_Mutation_p.A798T|CD163_ENST00000432237.2_Missense_Mutation_p.A765T	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	765	SRCR 7.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						GCATTAATGGCCTCTCCACAG	0.532000													80	176					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135498612	135498612	+	Splice_Site	SNP	G	G	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chrX:135498612G>C	ENST00000394143.1	+	26	9496		c.e26-1		GPR112_ENST00000287534.4_Intron|GPR112_ENST00000370652.1_Splice_Site|GPR112_ENST00000412101.1_Splice_Site|GPR112_ENST00000394141.1_Splice_Site	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112						neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CTTTACTGCAGATGACTTTGA	0.313000													11	28					0	0	1	0	0
ZNF365	22891	broad.mit.edu	37	10	64136649	64136649	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr10:64136649A>T	ENST00000395254.3	+	2	977	c.697A>T	c.(697-699)Agg>Tgg	p.R233W	ZNF365_ENST00000466727.1_Intron|ZNF365_ENST00000410046.3_Missense_Mutation_p.R233W|ZNF365_ENST00000395255.3_Missense_Mutation_p.R233W	NM_014951.2	NP_055766.2	Q70YC4	TALAN_HUMAN	zinc finger protein 365	0										breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	Prostate(12;0.0297)|all_hematologic(501;0.228)					AGCTGTACTGAGGCAACGCCT	0.507000													65	16					0	0	1	0	0
TRMT6	51605	broad.mit.edu	37	20	5923388	5923388	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr20:5923388G>A	ENST00000203001.2	-	7	842	c.712C>T	c.(712-714)Cgg>Tgg	p.R238W	TRMT6_ENST00000453074.2_Missense_Mutation_p.R68W|TRMT6_ENST00000473131.1_5'UTR	NM_015939.3	NP_057023.2	Q9UJA5	TRM6_HUMAN	tRNA methyltransferase 6 homolog (S. cerevisiae)	238					regulation of translational initiation|tRNA processing	nucleus	protein binding|translation initiation factor activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)	15						GTTGCTGCCCGAACAGGTCCT	0.428000													38	212					0	0	1	0	0
PLIN4	729359	broad.mit.edu	37	19	4512107	4512107	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr19:4512107G>T	ENST00000301286.3	-	3	1822	c.1823C>A	c.(1822-1824)aCc>aAc	p.T608N		NM_001080400.1	NP_001073869.1	Q96Q06	PLIN4_HUMAN	perilipin 4	608	27 X 33 AA approximate tandem repeat.					lipid particle|plasma membrane				NS(2)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|soft_tissue(1)|stomach(2)	41						AGTTTTGGTGGTGTCCATGCC	0.592000													6	439					0.00116845	0.00117917	1	1	0
CEP112	201134	broad.mit.edu	37	17	64024480	64024480	+	Nonsense_Mutation	SNP	A	A	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr17:64024480A>C	ENST00000392769.2	-	15	1765	c.1547T>G	c.(1546-1548)tTa>tGa	p.L516*	CEP112_ENST00000541355.1_Nonsense_Mutation_p.L151*|CEP112_ENST00000535342.2_Nonsense_Mutation_p.L516*|CEP112_ENST00000537949.1_Nonsense_Mutation_p.L474*	NM_145036.3	NP_659473.2	Q8N8E3	CE112_HUMAN	centrosomal protein 112kDa	516						centrosome				NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(8)|lung(11)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	28						CTGCTGTTTTAATTGACAGAC	0.318000													55	42					0	0	1	0	0
NCOA4	8031	broad.mit.edu	37	10	51580916	51580916	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr10:51580916G>A	ENST00000452682.1	+	5	619	c.367G>A	c.(367-369)Gag>Aag	p.E123K	NCOA4_ENST00000414907.2_Intron|NCOA4_ENST00000443446.1_Missense_Mutation_p.E107K|NCOA4_ENST00000438493.1_Missense_Mutation_p.E123K|NCOA4_ENST00000344348.6_Missense_Mutation_p.E107K|NCOA4_ENST00000374087.4_Missense_Mutation_p.E107K|NCOA4_ENST00000430396.2_Intron|NCOA4_ENST00000374082.1_Missense_Mutation_p.E107K|NCOA4_ENST00000498586.1_3'UTR	NM_001145260.1	NP_001138732.1	Q13772	NCOA4_HUMAN	nuclear receptor coactivator 4	107					androgen receptor signaling pathway|male gonad development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	androgen receptor binding|transcription coactivator activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|skin(1)	5						TCATCAACTGGAGTGTACCCA	0.388000			T	RET	papillary thyroid								15	2					0	0	1	0	0
ADH1A	124	broad.mit.edu	37	4	100201315	100201315	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr4:100201315C>T	ENST00000209668.2	-	7	1063	c.950G>A	c.(949-951)gGa>gAa	p.G317E	RP11-696N14.1_ENST00000500358.2_RNA|RP11-696N14.1_ENST00000506160.1_RNA	NM_000667.3	NP_000658.1	P07327	ADH1A_HUMAN	alcohol dehydrogenase 1A (class I), alpha polypeptide	317					ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)	25				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)	AAGAATAGCTCCCTTCCAGGT	0.468000													113	169					0	0	1	0	0
EFTUD2	9343	broad.mit.edu	37	17	42937886	42937886	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr17:42937886G>A	ENST00000426333.2	-	17	1930	c.1633C>T	c.(1633-1635)Cct>Tct	p.P545S	EFTUD2_ENST00000591382.1_Missense_Mutation_p.P545S|EFTUD2_ENST00000592576.1_Missense_Mutation_p.P535S|EFTUD2_ENST00000402521.3_Missense_Mutation_p.P510S	NM_001142605.1|NM_001258354.1|NM_004247.3	NP_001136077.1|NP_001245283.1|NP_004238.3	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain containing 2	545						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	32		Prostate(33;0.109)				TTGCCAGCAGGAACACGGTTC	0.428000													19	46					0	0	1	0	0
OPA1	4976	broad.mit.edu	37	3	193332657	193332657	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr3:193332657C>T	ENST00000361510.2	+	2	412	c.178C>T	c.(178-180)Cag>Tag	p.Q60*	OPA1_ENST00000361715.2_Nonsense_Mutation_p.Q60*|OPA1_ENST00000392438.3_Nonsense_Mutation_p.Q60*|OPA1_ENST00000361908.3_Nonsense_Mutation_p.Q60*|OPA1_ENST00000487986.1_3'UTR|OPA1_ENST00000361150.2_Nonsense_Mutation_p.Q60*|OPA1_ENST00000361828.2_Nonsense_Mutation_p.Q60*	NM_130837.2	NP_570850.2	O60313	OPA1_HUMAN	optic atrophy 1 (autosomal dominant)	60					apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(4)|lung(15)|upper_aerodigestive_tract(1)|urinary_tract(2)	31	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)		gacatcctttcagcagttctc	0.393000													13	34					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131887583	131887583	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr7:131887583T>C	ENST00000359827.3	-	12	3370	c.2408A>G	c.(2407-2409)aAg>aGg	p.K803R	PLXNA4_ENST00000321063.4_Missense_Mutation_p.K803R			Q9HCM2	PLXA4_HUMAN	plexin A4	803	PSI 3.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						GGCTCCACACTTGTAGAGGTG	0.632000													4	21					0	0	1	0	0
BZW1	9689	broad.mit.edu	37	2	201683058	201683058	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr2:201683058G>A	ENST00000409600.1	+	8	1216	c.761G>A	c.(760-762)cGt>cAt	p.R254H	BZW1_ENST00000452790.2_Missense_Mutation_p.R286H|BZW1_ENST00000409226.1_Missense_Mutation_p.R258H	NM_001207067.1|NM_014670.3	NP_001193996.1|NP_055485.2	Q7L1Q6	BZW1_HUMAN	basic leucine zipper and W2 domains 1	254	W2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	protein binding			breast(1)|kidney(2)|large_intestine(1)|lung(2)	6						ATCGGAGCTCGTAAGGAGCTC	0.403000													14	12					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95480630	95480630	+	RNA	SNP	C	C	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr2:95480630C>T	ENST00000432432.2	-	0	2730					NR_040113.1																						gccccagccccttgcaaacat	0.393000													4	11					0	0	1	0	0
GIMAP7	168537	broad.mit.edu	37	7	150217209	150217209	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr7:150217209A>C	ENST00000313543.4	+	2	304	c.147A>C	c.(145-147)aaA>aaC	p.K49N		NM_153236.3	NP_694968.1	Q8NHV1	GIMA7_HUMAN	GTPase, IMAP family member 7	49							GTP binding			breast(1)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	17			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ACTGTCAAAAAGCATCCCGGG	0.498000													6	75					0	0	1	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587576	43587576	+	RNA	SNP	A	A	G	rs145439557	by1000genomes	TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr17:43587576A>G	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							tctgaaaagaaaagaaaaaaa	0.428000													3	27					0	0	1	0	0
PRKAG3	53632	broad.mit.edu	37	2	219688987	219688987	+	Silent	SNP	G	G	A			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr2:219688987G>A	ENST00000439262.2	-	12	1331	c.1236C>T	c.(1234-1236)caC>caT	p.H412H	PRKAG3_ENST00000545803.1_Silent_p.H253H|PRKAG3_ENST00000529249.1_Silent_p.H437H	NM_017431.2	NP_059127.2	Q9UGI9	AAKG3_HUMAN	protein kinase, AMP-activated, gamma 3 non-catalytic subunit	437	CBS 3.				cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|intracellular protein kinase cascade|regulation of fatty acid oxidation	cytosol	AMP-activated protein kinase activity|protein kinase binding			large_intestine(7)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	20		Renal(207;0.0474)		Epithelial(149;4.35e-07)|all cancers(144;8.96e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCAAGCTCTCGTGGGGCTGGC	0.582000													4	25					0	0	1	0	0
LTN1	26046	broad.mit.edu	37	21	30338215	30338215	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr21:30338215C>G	ENST00000389194.2	-	11	2278	c.2273G>C	c.(2272-2274)tGg>tCg	p.W758S	LTN1_ENST00000389195.2_Missense_Mutation_p.W758S|LTN1_ENST00000361371.5_Missense_Mutation_p.W712S	NM_015565.2	NP_056380.2	O94822	LTN1_HUMAN	listerin E3 ubiquitin protein ligase 1	712							ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(19)|ovary(5)|pancreas(1)|prostate(2)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)	60						AAGAGAATTCCATTTCAAGTC	0.308000													6	14					0	0	1	0	0
CGN	57530	broad.mit.edu	37	1	151491776	151491777	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr1:151491776_151491777delAG	ENST00000271636.7	+	2	914_915	c.781_782delAG	c.(781-783)agtfs	p.S261fs		NM_020770.2	NP_065821.1	Q9P2M7	CING_HUMAN	cingulin	255	Head.|Interacts with ZO-2.					myosin complex|tight junction	actin binding|motor activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GAGTCCTCTCAGTGGCTTTAGC	0.584													9	187	---	---	---	---					
PVRL4	81607	broad.mit.edu	37	1	161059028	161059030	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr1:161059028_161059030delAGC	ENST00000368012.3	-	1	359_361	c.57_59delGCT	c.(55-60)ctgcta>cta	p.19_20LL>L		NM_030916.2	NP_112178.2	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4	19					adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|urinary_tract(1)	20	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			TGCCAGCAGTAGCAGCAGCAGCA	0.567													7	179	---	---	---	---					
ANKRD20A8P	729171	broad.mit.edu	37	2	95515230	95515230	+	RNA	DEL	A	A	-			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr2:95515230delA	ENST00000432432.2	-	0	605					NR_040113.1																						TCTGCCTTGCAAACAACCCTC	0.438													2	4	---	---	---	---					
CAMK1	8536	broad.mit.edu	37	3	9803349	9803350	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr3:9803349_9803350delCA	ENST00000256460.3	-	6	698_699	c.521_522delTG	c.(520-522)gtgfs	p.V174fs	OGG1_ENST00000302008.8_Intron|OGG1_ENST00000383826.5_Intron|OGG1_ENST00000349503.5_Intron|OGG1_ENST00000449570.2_Intron|OGG1_ENST00000302036.7_Intron	NM_003656.4	NP_003647.1	Q14012	KCC1A_HUMAN	calcium/calmodulin-dependent protein kinase I	174	Protein kinase.				cell differentiation|nervous system development|positive regulation of muscle cell differentiation|signal transduction	cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	12	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.0475)		CGGTGGAGAGCACACTGCCCGG	0.589													15	91	---	---	---	---					
SYN2	6854	broad.mit.edu	37	3	12046124	12046126	+	RNA	DEL	AGC	AGC	-	rs76272937		TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr3:12046124_12046126delAGC	ENST00000432424.2	+	0	245_247							Q86VA8	Q86VA8_HUMAN	synapsin II						neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			breast(5)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	18						AGCCCCAGCAAGCGCCGAcgccg	0.764													2	4	---	---	---	---					
EPHA3	2042	broad.mit.edu	37	3	89448632	89448633	+	Frame_Shift_Del	DEL	TA	TA	-			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr3:89448632_89448633delTA	ENST00000452448.2	+	7	1683_1684	c.1596_1597delTA	c.(1594-1599)tgtatgfs	p.M533fs	EPHA3_ENST00000494014.1_Splice_Site|EPHA3_ENST00000336596.2_Splice_Site	NM_182644.2	NP_872585.1	P29320	EPHA3_HUMAN	EPH receptor A3	0						extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		GTCCAGACTGTATGTATTATTT	0.426										TSP Lung(6;0.00050)			18	47	---	---	---	---					
HIST1H1E	3008	broad.mit.edu	37	6	26156678	26156680	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr6:26156678_26156680delGAA	ENST00000304218.3	+	1	120_122	c.60_62delGAA	c.(58-63)gtgaag>gtg	p.K23del		NM_005321.2	NP_005312.1	P10412	H14_HUMAN	histone cluster 1, H1e	23					nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			NS(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|liver(1)|lung(9)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	26						AGACTCCCGTGAAGAAGAAGGCC	0.650													37	213	---	---	---	---					
TNFRSF10C	8794	broad.mit.edu	37	8	22969274	22969275	+	Frame_Shift_Ins	INS	-	-	C			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr8:22969274_22969275insC	ENST00000356864.3	+	2	634_635	c.102_103insC	c.(103-105)cccfs	p.P35fs	TNFRSF10C_ENST00000520607.1_3'UTR|TNFRSF10C_ENST00000540813.1_Intron	NM_003841.3	NP_003832	O14798	TR10C_HUMAN	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	35					apoptosis	anchored to membrane|integral to plasma membrane	TRAIL binding|transmembrane receptor activity			endometrium(1)|large_intestine(6)|lung(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	15		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0147)|COAD - Colon adenocarcinoma(73;0.0612)		AGGAGGAAGTTCCCCAGCAGAC	0.535													12	35	---	---	---	---					
MAFA	389692	broad.mit.edu	37	8	144511954	144511956	+	In_Frame_Del	DEL	TGG	TGG	-			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr8:144511954_144511956delTGG	ENST00000333480.2	-	1	620_622	c.621_623delCCA	c.(619-624)caccat>cat	p.207_208HH>H	MAFA_ENST00000528185.1_5'UTR	NM_201589.3	NP_963883.2	Q8NHW3	MAFA_HUMAN	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A	207	His-rich.				insulin secretion|nitric oxide mediated signal transduction|response to glucose stimulus	nucleus	protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.H208delH(3)		breast(1)|lung(1)|upper_aerodigestive_tract(2)	4	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.237)			CGCGCCGCCAtggtggtggtggt	0.744										HNSCC(29;0.082)			5	3	---	---	---	---					
TSTD2	158427	broad.mit.edu	37	9	100372706	100372722	+	Frame_Shift_Del	DEL	GAAAACAGTGAGCTCCT	GAAAACAGTGAGCTCCT	-			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr9:100372706_100372722delGAAAACAGTGAGCTCCT	ENST00000341170.4	-	6	1123_1139	c.741_757delAGGAGCTCACTGTTTTC	c.(739-759)ggaggagctcactgttttccafs	p.GAHCFP248fs	TSTD2_ENST00000354801.2_Intron	NM_139246.4	NP_640339.4	Q5T7W7	TSTD2_HUMAN	thiosulfate sulfurtransferase (rhodanese)-like domain containing 2	248										large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	15						CGCAATTCTGGAAAACAGTGAGCTCCTCCTTTGCTGG	0.429													14	34	---	---	---	---					
CSAD	51380	broad.mit.edu	37	12	53553938	53553939	+	Frame_Shift_Ins	INS	-	-	T			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr12:53553938_53553939insT	ENST00000267085.4	-	14	1445_1446	c.1212_1213insA	c.(1210-1215)ctggagfs	p.E405fs	RP11-1136G11.8_ENST00000550908.1_lincRNA|CSAD_ENST00000444623.1_Frame_Shift_Ins_p.E378fs|CSAD_ENST00000379843.3_Frame_Shift_Ins_p.E231fs|CSAD_ENST00000379846.1_Frame_Shift_Ins_p.E231fs|CSAD_ENST00000453446.2_Frame_Shift_Ins_p.E378fs	NM_001244706.1|NM_015989.4	NP_001231635.1|NP_057073.4	Q9Y600	CSAD_HUMAN	cysteine sulfinic acid decarboxylase	378					carboxylic acid metabolic process		pyridoxal phosphate binding|sulfinoalanine decarboxylase activity			kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(4)	14					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	ATGCGCCGCTCCAGCCCTTGAT	0.649											OREG0021859	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	81	---	---	---	---					
NID2	22795	broad.mit.edu	37	14	52520521	52520522	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr14:52520521_52520522delTC	ENST00000216286.5	-	5	1203_1204	c.1204_1205delGA	c.(1204-1206)gatfs	p.D402fs	NID2_ENST00000541773.1_Frame_Shift_Del_p.D349fs	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	402						basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					AGCCAGTGAATCTCTGTCTACC	0.564													29	66	---	---	---	---					
GRIN2A	2903	broad.mit.edu	37	16	9984931	9984931	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr16:9984931delC	ENST00000396573.2	-	5	1343	c.1034delG	c.(1033-1035)ggcfs	p.G345fs	GRIN2A_ENST00000330684.3_Frame_Shift_Del_p.G345fs|GRIN2A_ENST00000404927.2_Frame_Shift_Del_p.G345fs|GRIN2A_ENST00000562109.1_Frame_Shift_Del_p.G345fs|GRIN2A_ENST00000396575.2_Frame_Shift_Del_p.G345fs|GRIN2A_ENST00000535259.1_Frame_Shift_Del_p.G188fs	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	345					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TAAGTCTTTGCCATCCCATGT	0.448													333	65	---	---	---	---					
KRTAP2-4	85294	broad.mit.edu	37	17	39221759	39221773	+	In_Frame_Del	DEL	GCAGGGGGGCCGGCA	GCAGGGGGGCCGGCA	-	rs349782	by1000genomes	TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr17:39221759_39221773delGCAGGGGGGCCGGCA	ENST00000394015.2	-	1	358_372	c.325_339delTGCCGGCCCCCCTGC	c.(325-339)tgccggcccccctgcdel	p.CRPPC109del		NM_033184.3	NP_149440.1	Q9BYR9	KRA24_HUMAN	keratin associated protein 2-4	109	10 X 5 AA repeats of C-C-[CDPQRW]- [ADPRS]-[CIPSTV].					keratin filament				skin(1)	1		Breast(137;0.000496)|Myeloproliferative disorder(1115;0.204)	STAD - Stomach adenocarcinoma(17;0.000371)			TCGGCTGGCCGCAGGGGGGCCGGCAGCAGGGGGAC	0.660													3	5	---	---	---	---					
FTSJ3	117246	broad.mit.edu	37	17	61899155	61899157	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr17:61899155_61899157delCTC	ENST00000427159.2	-	15	2167_2169	c.1522_1524delGAG	c.(1522-1524)gagdel	p.E508del		NM_017647.3	NP_060117.3	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3 (E. coli)	508					RNA methylation|rRNA processing	nucleolus	methyltransferase activity|nucleic acid binding			breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	27						GCAGTGGATTCTCCTCCTCCTCC	0.537													7	288	---	---	---	---					
CEP192	55125	broad.mit.edu	37	18	13087586	13087587	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr18:13087586_13087587delAG	ENST00000506447.1	+	32	6014_6015	c.5934_5935delAG	c.(5932-5937)acagaafs	p.E1979fs	CEP192_ENST00000325971.8_Frame_Shift_Del_p.E1383fs|CEP192_ENST00000540847.2_3'UTR|CEP192_ENST00000430049.2_Frame_Shift_Del_p.E1504fs	NM_032142.3	NP_115518.3	B7ZMF0	B7ZMF0_HUMAN	centrosomal protein 192kDa	1574										NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(36)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						AAACTGCAACAGAACTATCAAC	0.312													17	60	---	---	---	---					
RPL17-C18orf32	100526842	broad.mit.edu	37	18	47017211	47017212	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr18:47017211_47017212delCT	ENST00000584895.1	-	3	181_182	c.167_168delAG	c.(166-168)cagfs	p.Q56fs	RPL17-C18orf32_ENST00000332968.6_Frame_Shift_Del_p.Q18fs|MIR1539_ENST00000581232.1_RNA|RPL17_ENST00000580261.1_Frame_Shift_Del_p.Q56fs|RPL17_ENST00000580210.1_Frame_Shift_Del_p.Q46fs|RPL17_ENST00000579408.1_Frame_Shift_Del_p.Q56fs|RPL17_ENST00000579248.1_Frame_Shift_Del_p.Q56fs|RPL17_ENST00000581091.1_5'UTR|RPL17_ENST00000418495.1_Frame_Shift_Del_p.Q56fs|RPL17_ENST00000581373.1_Frame_Shift_Del_p.Q18fs	NM_001199355.1|NM_001199356.1	NP_001186284.1|NP_001186285.1																					ATGGTACACACTGTTTCTGTAA	0.411													18	82	---	---	---	---					
KANK3	256949	broad.mit.edu	37	19	8398950	8398961	+	In_Frame_Del	DEL	TCGCTGTCGCCA	TCGCTGTCGCCA	-	rs111751275		TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr19:8398950_8398961delTCGCTGTCGCCA	ENST00000330915.3	-	5	1532_1543	c.1467_1478delTGGCGACAGCGA	c.(1465-1479)gatggcgacagcgag>gag	p.DGDS489del	KANK3_ENST00000593649.1_In_Frame_Del_p.DGDS489del	NM_198471.2	NP_940873.2	Q6NY19	KANK3_HUMAN	KN motif and ankyrin repeat domains 3	489								p.D489_S492delDGDS(2)		breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	9						GCCACCGTTCTCGCTGTCGCCATCGCTGTCGC	0.717													2	4	---	---	---	---					
FAM83D	81610	broad.mit.edu	37	20	37555322	37555323	+	In_Frame_Ins	INS	-	-	GCG			TCGA-DK-A6B1-01A-12D-A30E-08	TCGA-DK-A6B1-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d81e9174-a1c0-469b-9ab6-1b2e8622a646	6d78964f-aa0d-4062-980d-db9e8ca784c1	g.chr20:37555322_37555323insGCG	ENST00000217429.4	+	1	368_369	c.327_328insGCG	c.(328-330)gcg>GCGgcg	p.110_110A>AA		NM_030919.2	NP_112181.2	Q9H4H8	FA83D_HUMAN	family with sequence similarity 83, member D	80					cell division|mitosis	cytoplasm|spindle pole				endometrium(2)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)|stomach(1)	28		Myeloproliferative disorder(115;0.00878)				GAGAGGAGGGCgcggcggcggc	0.718													3	4	---	---	---	---					
