Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PPP1R3D	5509	broad.mit.edu	37	20	58514322	58514322	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr20:58514322C>G	ENST00000370996.3	-	1	1030	c.665G>C	c.(664-666)cGg>cCg	p.R222P	FAM217B_ENST00000358293.3_Intron	NM_006242.3	NP_006233.1	O95685	PPR3D_HUMAN	protein phosphatase 1, regulatory subunit 3D	222	CBM21.				glycogen metabolic process		protein binding|protein serine/threonine phosphatase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|urinary_tract(1)	13	all_lung(29;0.00391)		BRCA - Breast invasive adenocarcinoma(7;5.12e-09)			CCCGCGCCACCGCGCCACCGC	0.682000													15	22					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62237148	62237148	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr1:62237148C>G	ENST00000371158.2	+	6	684	c.570C>G	c.(568-570)caC>caG	p.H190Q	INADL_ENST00000316485.6_Missense_Mutation_p.H190Q	NM_176877.2	NP_795352	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	190	PDZ 1.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						CCATTAATCACACGCCATTGG	0.348000													21	47					0	0	1	0	0
TRIM56	81844	broad.mit.edu	37	7	100732419	100732419	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr7:100732419G>C	ENST00000306085.6	+	3	2123	c.1826G>C	c.(1825-1827)gGc>gCc	p.G609A		NM_030961.1	NP_112223.1	Q9BRZ2	TRI56_HUMAN	tripartite motif containing 56	609					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Lung NSC(181;0.136)|all_lung(186;0.182)					AGCGTGGCGGGCCACGTGGAG	0.697000													26	82					0	0	1	0	0
AC096579.13	0	broad.mit.edu	37	2	89160846	89160846	+	RNA	SNP	G	G	A	rs114271391	by1000genomes	TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr2:89160846G>A	ENST00000452230.1	-	0	39				AC096579.7_ENST00000430694.1_RNA																							CCCCAATGAAGTTATTTTGAT	0.418000													2	1					0	0	1	0	0
RB1	5925	broad.mit.edu	37	13	48936995	48936995	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr13:48936995C>T	ENST00000267163.4	+	8	901	c.763C>T	c.(763-765)Cga>Tga	p.R255*		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	255					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(6)|p.R255*(1)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AACACCCAGGCGAGGTCAGAA	0.348000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			22	8					0	0	1	0	0
ALKBH5	54890	broad.mit.edu	37	17	18088087	18088087	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr17:18088087T>A	ENST00000399138.4	+	1	535	c.530T>A	c.(529-531)gTg>gAg	p.V177E	ALKBH5_ENST00000541285.1_Intron	NM_017758.3	NP_060228.3	Q6P6C2	ALKB5_HUMAN	alkB, alkylation repair homolog 5 (E. coli)	177						integral to membrane	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(2)|ovary(1)|skin(1)	10	all_neural(463;0.228)					CAAAAGCTGGTGGAGCACCGC	0.672000													10	27					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73466770	73466770	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr10:73466770G>A	ENST00000224721.6	+	25	3090	c.3085G>A	c.(3085-3087)Gtg>Atg	p.V1029M	CDH23_ENST00000299366.7_Missense_Mutation_p.V1069M	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	1024	Cadherin 10.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						GGACAACGACGTGGGCCTCAA	0.657000													5	9					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149529936	149529936	+	RNA	SNP	G	G	A			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr7:149529936G>A	ENST00000378016.2	+	0	15353							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CTGAACCTGCGCTGTCTGGGT	0.677000													25	22					0	0	1	0	0
IGLV5-45	28781	broad.mit.edu	37	22	22730716	22730716	+	RNA	SNP	T	T	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr22:22730716T>G	ENST00000390296.2	+	0	239																											TCTCCTGAGGTACAAATCAGA	0.532000													24	79					0	0	1	0	0
CCDC125	202243	broad.mit.edu	37	5	68588043	68588043	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr5:68588043C>T	ENST00000396496.2	-	10	1178	c.1071G>A	c.(1069-1071)tgG>tgA	p.W357*	CCDC125_ENST00000460090.1_Intron|CCDC125_ENST00000396499.1_Nonsense_Mutation_p.W357*|CCDC125_ENST00000383374.2_Intron|CCDC125_ENST00000511257.1_Nonsense_Mutation_p.W232*			Q86Z20	CC125_HUMAN	coiled-coil domain containing 125	357						cytoplasm				breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(7)|urinary_tract(1)	19		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.2e-56)|Epithelial(20;2.31e-52)|all cancers(19;5.85e-48)|Lung(70;0.0183)		TCCAATTCATCCATTTTGTTG	0.313000													25	51					0	0	1	0	0
STAT2	6773	broad.mit.edu	37	12	56744888	56744888	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr12:56744888C>T	ENST00000314128.4	-	10	1051	c.1028G>A	c.(1027-1029)cGa>cAa	p.R343Q	STAT2_ENST00000418572.2_Missense_Mutation_p.R339Q|STAT2_ENST00000557235.1_Missense_Mutation_p.R339Q			P52630	STAT2_HUMAN	signal transducer and activator of transcription 2, 113kDa	343					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|endometrium(2)|kidney(5)|large_intestine(7)|liver(2)|lung(10)|ovary(1)|skin(3)	31						CAACCTTGTTCGGACGGTGAA	0.517000													36	25					0	0	1	0	0
NAT16	375607	broad.mit.edu	37	7	100815663	100815663	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr7:100815663G>C	ENST00000300303.2	-	4	1045	c.807C>G	c.(805-807)gaC>gaG	p.D269E	NAT16_ENST00000455377.1_Missense_Mutation_p.D269E	NM_198571.2	NP_940973.2	Q8N8M0	CG052_HUMAN	N-acetyltransferase 16 (GCN5-related, putative)	269							N-acetyltransferase activity										GCGCGCGGCTGTCCACGCGCC	0.701000													4	11					0	0	1	0	0
BMP7	655	broad.mit.edu	37	20	55840819	55840819	+	Silent	SNP	G	G	A			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr20:55840819G>A	ENST00000395863.3	-	1	865	c.360C>T	c.(358-360)agC>agT	p.S120S	BMP7_ENST00000395864.3_Silent_p.S120S|BMP7_ENST00000450594.2_Silent_p.S120S	NM_001719.2	NP_001710.1	P18075	BMP7_HUMAN	bone morphogenetic protein 7	120					BMP signaling pathway|cartilage development|cellular response to hypoxia|epithelial to mesenchymal transition|growth|mesonephros development|negative regulation of glomerular mesangial cell proliferation|negative regulation of MAP kinase activity|negative regulation of mitosis|negative regulation of neuron differentiation|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of phosphorylation|negative regulation of striated muscle cell apoptosis|negative regulation of transcription, DNA-dependent|ossification|pathway-restricted SMAD protein phosphorylation|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|protein localization to nucleus|regulation of removal of superoxide radicals|SMAD protein signal transduction|steroid hormone mediated signaling pathway|ureteric bud development	extracellular space	cytokine activity|growth factor activity			endometrium(4)|kidney(1)|large_intestine(7)|lung(6)|prostate(1)|skin(1)	20	all_lung(29;0.0133)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;2.49e-13)|Epithelial(14;1.74e-08)|all cancers(14;2.05e-07)			TATCTTGCAGGCTGGCCAGAG	0.662000													6	5					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238277575	238277575	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr2:238277575C>T	ENST00000295550.4	-	10	4983	c.4531G>A	c.(4531-4533)Ggg>Agg	p.G1511R	COL6A3_ENST00000472056.1_Missense_Mutation_p.G904R|COL6A3_ENST00000347401.3_Missense_Mutation_p.G1310R|COL6A3_ENST00000409809.1_Missense_Mutation_p.G1305R|COL6A3_ENST00000346358.4_Missense_Mutation_p.G1311R|COL6A3_ENST00000353578.4_Missense_Mutation_p.G1305R	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1511	Nonhelical region.|VWFA 8.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		AGTGGGGACCCCCCTCTGAGC	0.562000													20	44					0	0	1	0	0
INPP5E	56623	broad.mit.edu	37	9	139327638	139327638	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr9:139327638G>C	ENST00000371712.3	-	4	1530	c.1128C>G	c.(1126-1128)ttC>ttG	p.F376L		NM_019892.4	NP_063945.2	Q9NRR6	INP5E_HUMAN	inositol polyphosphate-5-phosphatase, 72 kDa	376						cilium axoneme|cytoskeleton|Golgi cisterna membrane	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity			NS(1)|endometrium(1)|lung(4)|skin(3)	9		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.36e-06)|Epithelial(140;1.4e-05)		CCCTGCGGATGAAGAGCGACA	0.682000													9	8					0	0	1	0	0
NOL6	65083	broad.mit.edu	37	9	33469023	33469023	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr9:33469023G>A	ENST00000379471.2	-	7	1046	c.959C>T	c.(958-960)tCa>tTa	p.S320L	NOL6_ENST00000464829.1_5'UTR|NOL6_ENST00000455041.2_Missense_Mutation_p.S260L			Q9H6R4	NOL6_HUMAN	nucleolar protein 6 (RNA-associated)	320					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			endometrium(4)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|skin(2)	27			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		GCCCTGGGCTGAACTCAGAAT	0.597000													59	118					0	0	1	0	0
ZNF566	84924	broad.mit.edu	37	19	36940238	36940238	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr19:36940238G>C	ENST00000454319.1	-	5	1035	c.901C>G	c.(901-903)Caa>Gaa	p.Q301E	ZNF566_ENST00000424129.2_Missense_Mutation_p.Q300E|ZNF566_ENST00000392170.2_Missense_Mutation_p.Q301E|ZNF566_ENST00000434377.2_Missense_Mutation_p.Q300E|ZNF566_ENST00000493391.1_Missense_Mutation_p.Q196E	NM_001145343.1|NM_001145344.1|NM_001145345.1	NP_001138815.1|NP_001138816.1|NP_001138817.1	Q969W8	ZN566_HUMAN	zinc finger protein 566	300					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(12)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24	Esophageal squamous(110;0.162)					CTCTGATGTTGAGTAAAGTTT	0.403000													35	77					0	0	1	0	0
LRRN4	164312	broad.mit.edu	37	20	6021797	6021797	+	Silent	SNP	G	G	A			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr20:6021797G>A	ENST00000378858.4	-	5	2318	c.2094C>T	c.(2092-2094)acC>acT	p.T698T		NM_152611.4	NP_689824.2	Q8WUT4	LRRN4_HUMAN	leucine rich repeat neuronal 4	698						integral to membrane				breast(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	27						ACAGCACCACGGTGCTGGCGA	0.687000													6	7					0	0	1	0	0
IGKJ4	28947	broad.mit.edu	37	2	89160424	89160424	+	RNA	SNP	C	C	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr2:89160424C>G	ENST00000452230.1	-	0	39				IGKJ4_ENST00000390239.2_RNA|AC096579.7_ENST00000430694.1_RNA																							GGTCCCTCCGCCGAAAGTGAG	0.418000													15	13					0	0	1	0	0
FOLH1B	219595	broad.mit.edu	37	11	89405142	89405142	+	RNA	SNP	C	C	T	rs3018757	by1000genomes	TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr11:89405142C>T	ENST00000532352.1	+	0	1082							Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						GTTCATGAAACTGTGAGGAGC	0.433000													4	110					0	0	1	0	0
IGHV3-21	28444	broad.mit.edu	37	14	106692121	106692121	+	RNA	SNP	C	C	T			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr14:106692121C>T	ENST00000390607.2	-	0	82																											AGCCCCAGTTCCATGGTGAAT	0.502000													12	33					0	0	1	0	0
ADCY5	111	broad.mit.edu	37	3	123166615	123166615	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr3:123166615G>C	ENST00000462833.1	-	1	1990	c.778C>G	c.(778-780)Cac>Gac	p.H260D		NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	260					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		CGCGCCGCGTGGAAGGCCAAC	0.677000													16	18					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144940303	144940303	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr8:144940303G>C	ENST00000525985.1	-	2	7190	c.7119C>G	c.(7117-7119)aaC>aaG	p.N2373K				P58107	EPIPL_HUMAN	epiplakin 1	2373						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCAGGACGCGGTTCATCTCCT	0.682000													23	454					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19745456	19745456	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr19:19745456C>G	ENST00000203556.4	-	18	2081	c.1944G>C	c.(1942-1944)aaG>aaC	p.K648N	GMIP_ENST00000587238.1_Missense_Mutation_p.K622N|GMIP_ENST00000445806.2_Missense_Mutation_p.K619N|GMIP_ENST00000586269.1_Intron	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	648	Rho-GAP.				negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						CATGCAAGGTCTTAGCCAGAG	0.632000													66	104					0	0	1	0	0
USP28	57646	broad.mit.edu	37	11	113679918	113679918	+	Silent	SNP	G	G	C			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr11:113679918G>C	ENST00000003302.4	-	17	2099	c.2031C>G	c.(2029-2031)ctC>ctG	p.L677L	USP28_ENST00000260188.5_Silent_p.L677L|USP28_ENST00000544967.1_Silent_p.L385L|USP28_ENST00000545540.1_Silent_p.L552L	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	677					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		TGTAATGCTTGAGTTCCACAG	0.468000													145	156					0	0	1	0	0
RALGDS	5900	broad.mit.edu	37	9	135985048	135985048	+	Silent	SNP	G	G	A			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr9:135985048G>A	ENST00000393160.3	-	4	737	c.384C>T	c.(382-384)tcC>tcT	p.S128S	RALGDS_ENST00000542690.1_Silent_p.S254S|RALGDS_ENST00000372050.3_Silent_p.S183S|RALGDS_ENST00000393157.3_Silent_p.S182S|RALGDS_ENST00000372062.3_Silent_p.S154S|RALGDS_ENST00000372047.3_Silent_p.S171S	NM_001042368.1	NP_001035827.1	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	183	N-terminal Ras-GEF.				nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		CATCCTCGTCGGAATAGGGGA	0.552000			T	CIITA	"""PMBL, Hodgkin Lymphona, """								6	56					0	0	1	0	0
IGKV5-2	28907	broad.mit.edu	37	2	89197019	89197019	+	RNA	SNP	A	A	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr2:89197019A>G	ENST00000390244.2	+	0	127																											CAGGGCAGAAACGACACTCAC	0.393000													11	5					0	0	1	0	0
IGLV7-43	28776	broad.mit.edu	37	22	22749796	22749796	+	RNA	SNP	A	A	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr22:22749796A>G	ENST00000390298.2	+	0	354																											GAGGCTGAGTATTACTGCCTG	0.557000													28	67					0	0	1	0	0
KIF13A	63971	broad.mit.edu	37	6	17834270	17834270	+	Silent	SNP	G	G	A			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr6:17834270G>A	ENST00000378814.5	-	12	1187	c.1188C>T	c.(1186-1188)ctC>ctT	p.L396L	KIF13A_ENST00000378826.2_Silent_p.L396L|KIF13A_ENST00000259711.6_Silent_p.L396L|KIF13A_ENST00000378816.5_Silent_p.L396L|KIF13A_ENST00000378843.2_Silent_p.L396L	NM_001105568.2	NP_001099038.1	Q9H1H9	KI13A_HUMAN	kinesin family member 13A	396					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding	p.L396L(1)		breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			CAGACTCTTCGAGCTTCTCCT	0.383000													7	9					0	0	1	0	0
POLE	5426	broad.mit.edu	37	12	133249288	133249288	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr12:133249288C>G	ENST00000320574.5	-	15	1654	c.1611G>C	c.(1609-1611)gaG>gaC	p.E537D	POLE_ENST00000535270.1_Missense_Mutation_p.E510D	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	537					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CGACGTAGGTCTCAGAGTCCA	0.577000								DNA polymerases (catalytic subunits)					26	57					0	0	1	0	0
IRF3	3661	broad.mit.edu	37	19	50162957	50162957	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr19:50162957T>G	ENST00000597198.1	-	8	1613	c.1232A>C	c.(1231-1233)tAc>tCc	p.Y411S	IRF3_ENST00000377135.4_Missense_Mutation_p.Y284S|IRF3_ENST00000377139.3_Missense_Mutation_p.Y411S|IRF3_ENST00000600911.1_Silent_p.L372L|IRF3_ENST00000596822.1_Silent_p.L99L|IRF3_ENST00000599144.1_Missense_Mutation_p.Y265S|IRF3_ENST00000601291.1_Silent_p.L416L|IRF3_ENST00000309877.7_Missense_Mutation_p.Y411S|IRF3_ENST00000598808.1_Missense_Mutation_p.Y265S|IRF3_ENST00000593922.1_Missense_Mutation_p.Y265S|IRF3_ENST00000600022.1_Missense_Mutation_p.Y138S|IRF3_ENST00000599680.1_5'UTR|IRF3_ENST00000599223.1_Missense_Mutation_p.Y284S|IRF3_ENST00000596765.1_Missense_Mutation_p.Y138S			Q14653	IRF3_HUMAN	interferon regulatory factor 3	411					interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|endosome membrane|nucleoplasm|plasma membrane	DNA binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|large_intestine(2)|lung(4)|ovary(2)|stomach(1)	10		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.02)		GTCCTGCAGGTAGGCCTTGTA	0.632000													12	13					0	0	1	0	0
KIF26A	26153	broad.mit.edu	37	14	104642802	104642802	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr14:104642802C>G	ENST00000315264.7	+	11	3638	c.3260C>G	c.(3259-3261)gCt>gGt	p.A1087G	KIF26A_ENST00000423312.2_Missense_Mutation_p.A1226G			Q9ULI4	KI26A_HUMAN	kinesin family member 26A	1226					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	21		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		GTGGGCTGTGCTCGCCTGGGC	0.697000													10	14					0	0	1	0	0
LRP10	26020	broad.mit.edu	37	14	23344361	23344361	+	Silent	SNP	C	C	T			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr14:23344361C>T	ENST00000359591.4	+	4	1004	c.313C>T	c.(313-315)Ctg>Ttg	p.L105L	LRP10_ENST00000546834.1_Silent_p.L105L	NM_014045.3	NP_054764.2	Q7Z4F1	LRP10_HUMAN	low density lipoprotein receptor-related protein 10	105	CUB 1.				endocytosis	coated pit|integral to membrane				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(2)	32	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		TCCCAGCCCTCTGCAGCTGCC	0.622000													14	21					0	0	1	0	0
SEMA3D	223117	broad.mit.edu	37	7	84651827	84651827	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr7:84651827A>C	ENST00000284136.6	-	11	1337	c.1294T>G	c.(1294-1296)Tac>Gac	p.Y432D	SEMA3D_ENST00000484038.1_5'UTR	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	432	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						GCAACTGGGTATACGGACTTA	0.448000													51	129					0	0	1	0	0
REEP4	80346	broad.mit.edu	37	8	21997593	21997593	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr8:21997593G>C	ENST00000306306.3	-	4	654	c.186C>G	c.(184-186)ttC>ttG	p.F62L	REEP4_ENST00000523293.1_Missense_Mutation_p.F62L|REEP4_ENST00000334530.5_Missense_Mutation_p.F62L	NM_025232.2	NP_079508.2	Q9H6H4	REEP4_HUMAN	receptor accessory protein 4	62						integral to membrane				kidney(1)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	7				Colorectal(74;0.00187)|COAD - Colon adenocarcinoma(73;0.061)|READ - Rectum adenocarcinoma(644;0.0993)		AGTAGAAAGGGAACCTGTCAC	0.612000													7	13					0	0	1	0	0
ALKBH5	54890	broad.mit.edu	37	17	18088115	18088115	+	Silent	SNP	C	C	T			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr17:18088115C>T	ENST00000399138.4	+	1	563	c.558C>T	c.(556-558)ttC>ttT	p.F186F	ALKBH5_ENST00000541285.1_Intron	NM_017758.3	NP_060228.3	Q6P6C2	ALKB5_HUMAN	alkB, alkylation repair homolog 5 (E. coli)	186						integral to membrane	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(2)|ovary(1)|skin(1)	10	all_neural(463;0.228)					CCGAGGGCTTCGTCAACAGCG	0.652000													7	21					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82595143	82595143	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr7:82595143G>C	ENST00000333891.9	-	4	4298	c.3961C>G	c.(3961-3963)Cca>Gca	p.P1321A	PCLO_ENST00000423517.2_Missense_Mutation_p.P1321A	NM_033026.5	NP_149015.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein						cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GGTGGCTGTGGCTGTTCTTTT	0.403000													40	53					0	0	1	0	0
KIRREL3	84623	broad.mit.edu	37	11	126396467	126396467	+	Silent	SNP	G	G	A			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr11:126396467G>A	ENST00000525144.2	-	3	498	c.249C>T	c.(247-249)gaC>gaT	p.D83D	KIRREL3_ENST00000529097.2_Silent_p.D83D|KIRREL3_ENST00000525704.2_Silent_p.D83D	NM_032531.3	NP_115920.1	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3 (Drosophila)	83	Ig-like C2-type 1.				hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding			central_nervous_system(1)|endometrium(5)|large_intestine(11)|lung(8)|ovary(3)|prostate(1)	29	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)		GAGCCAAGCCGTCCTTGATCC	0.612000													7	8					0	0	1	0	0
IGLV7-46	28775	broad.mit.edu	37	22	22724423	22724423	+	RNA	SNP	T	T	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr22:22724423T>G	ENST00000390295.2	+	0	353																											TGAGGCTGAGTATTACTGCTT	0.567000													8	26					0	0	1	0	0
TNFRSF14	8764	broad.mit.edu	37	1	2491290	2491290	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr1:2491290C>G	ENST00000355716.4	+	4	632	c.333C>G	c.(331-333)tgC>tgG	p.C111W	TNFRSF14_ENST00000409119.1_Missense_Mutation_p.C111W	NM_003820.2	NP_003811.2	Q92956	TNR14_HUMAN	tumor necrosis factor receptor superfamily, member 14	111					immune response|interspecies interaction between organisms|T cell costimulation		tumor necrosis factor receptor activity			kidney(1)	1	all_cancers(77;0.000158)|all_epithelial(69;8.01e-05)|all_lung(157;0.0212)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.18e-20)|all_lung(118;1.67e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;1.1e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.02e-23)|GBM - Glioblastoma multiforme(42;1.11e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000326)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.199)		GCCGGAACTGCTCCAGGACAG	0.687000			"""Mis, N, F"""		follicular lymphoma								3	3					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127730942	127730942	+	Silent	SNP	C	C	T	rs138063920	by1000genomes	TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr5:127730942C>T	ENST00000508053.1	-	15	2078	c.1104G>A	c.(1102-1104)tcG>tcA	p.S368S	FBN2_ENST00000508989.1_Silent_p.S335S|FBN2_ENST00000262464.4_Silent_p.S368S			P35556	FBN2_HUMAN	fibrillin 2	368	TB 2.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TCACCAGGCCCGAGAAACACA	0.502000													14	22					0	0	1	0	0
SURF6	6838	broad.mit.edu	37	9	136198951	136198951	+	Silent	SNP	C	C	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr9:136198951C>G	ENST00000372022.4	-	5	1105	c.840G>C	c.(838-840)gtG>gtC	p.V280V	SURF6_ENST00000468290.1_5'UTR	NM_006753.4	NP_006744.2	O75683	SURF6_HUMAN	surfeit 6	280						granular component	DNA binding|RNA binding			endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	12				OV - Ovarian serous cystadenocarcinoma(145;1.16e-06)|Epithelial(140;8.34e-06)|all cancers(34;7.08e-05)		CACGGATCTTCACGCCCTCCG	0.687000													26	31					0	0	1	0	0
CT47B1	643311	broad.mit.edu	37	X	120008748	120008748	+	Splice_Site	SNP	A	A	T			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chrX:120008748A>T	ENST00000371311.3	-	1	1030		c.e1+1			NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1											breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						TAGCCCCCTTACCCTCGGGGG	0.687000													40	8					0	0	1	0	0
PDILT	204474	broad.mit.edu	37	16	20410468	20410468	+	Missense_Mutation	SNP	C	C	T	rs150116953	byFrequency	TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr16:20410468C>T	ENST00000302451.4	-	2	403	c.155G>A	c.(154-156)gGc>gAc	p.G52D		NM_174924.1	NP_777584.1	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis expressed	52					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(33)|prostate(3)|skin(1)|urinary_tract(1)	61						CTGGGTCAGGCCAGCGGGCGT	0.582000													29	47					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28992878	28992878	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr18:28992878G>A	ENST00000359747.4	+	15	2529	c.2500G>A	c.(2500-2502)Gta>Ata	p.V834I	DSG4_ENST00000308128.4_Missense_Mutation_p.V815I|RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	815					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CGGGTCTCCCGTAGGCTCTAT	0.433000													4	97					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65074702	65074702	+	Splice_Site	SNP	G	G	A			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr17:65074702G>A	ENST00000358691.5	-	33	5661	c.5495C>T	c.(5494-5496)gCg>gTg	p.A1832V	HELZ_ENST00000580168.1_Splice_Site_p.A1833V	NM_014877.3	NP_055692			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					CTTGGGTGGCGCTAAAAGCAG	0.507000													4	102					0	0	1	0	0
C10orf128	170371	broad.mit.edu	37	10	50373838	50373838	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr10:50373838G>A	ENST00000374148.1	-	4	296	c.242C>T	c.(241-243)aCc>aTc	p.T81I	C10orf128_ENST00000374151.3_Missense_Mutation_p.T81I|C10orf128_ENST00000474718.1_Missense_Mutation_p.T81I|C10orf128_ENST00000374153.2_Missense_Mutation_p.T81I			Q5T292	CJ128_HUMAN	chromosome 10 open reading frame 128	81						integral to membrane				breast(1)|large_intestine(1)|lung(1)	3						TAGCGGGATGGTGTCTAAACA	0.557000													19	35					0	0	1	0	0
TM4SF5	9032	broad.mit.edu	37	17	4686287	4686287	+	Silent	SNP	G	G	C			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr17:4686287G>C	ENST00000270560.3	+	4	565	c.534G>C	c.(532-534)gtG>gtC	p.V178V		NM_003963.2	NP_003954.2	O14894	T4S5_HUMAN	transmembrane 4 L six family member 5	178						integral to plasma membrane				large_intestine(2)|lung(3)|ovary(1)	6						TCCAGCTGGTGAACGCGACCA	0.597000													25	46					0	0	1	0	0
IGLV7-46	28775	broad.mit.edu	37	22	22724338	22724338	+	RNA	SNP	G	G	C			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr22:22724338G>C	ENST00000390295.2	+	0	268																											AACACTCCTGGACACCTGCCC	0.562000													7	14					0	0	1	0	0
FERMT3	83706	broad.mit.edu	37	11	63979189	63979189	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr11:63979189G>C	ENST00000279227.5	+	6	851	c.756G>C	c.(754-756)aaG>aaC	p.K252N	FERMT3_ENST00000345728.5_Missense_Mutation_p.K252N	NM_178443.2	NP_848537.1	Q86UX7	URP2_HUMAN	fermitin family member 3	252	FERM.				integrin activation|leukocyte cell-cell adhesion|platelet aggregation|regulation of cell-cell adhesion mediated by integrin	cell junction|cell projection|podosome	integrin binding			breast(1)|cervix(1)|endometrium(4)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	18						TGCGCTTCAAGTACTACAGCT	0.632000													19	28					0	0	1	0	0
SLFN11	91607	broad.mit.edu	37	17	33689794	33689794	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr17:33689794C>G	ENST00000394566.1	-	4	1305	c.1033G>C	c.(1033-1035)Gag>Cag	p.E345Q	SLFN11_ENST00000308377.4_Missense_Mutation_p.E345Q	NM_001104587.1|NM_001104588.1|NM_001104589.1|NM_001104590.1	NP_001098057.1|NP_001098058.1|NP_001098059.1|NP_001098060.1	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	345						nucleus	ATP binding			autonomic_ganglia(1)|breast(1)|kidney(3)|large_intestine(14)|lung(17)|ovary(1)|prostate(4)|skin(2)|stomach(5)|upper_aerodigestive_tract(2)	50		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		ACCCATTTCTCGGTTGTCAGG	0.488000													31	65					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140807667	140807667	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr9:140807667G>A	ENST00000371372.1	+	4	711	c.566G>A	c.(565-567)cGa>cAa	p.R189Q	CACNA1B_ENST00000371355.4_Missense_Mutation_p.R189Q|CACNA1B_ENST00000277549.5_5'UTR|CACNA1B_ENST00000371363.1_Missense_Mutation_p.R189Q|CACNA1B_ENST00000371357.1_Missense_Mutation_p.R189Q|CACNA1B_ENST00000277551.2_Missense_Mutation_p.R189Q	NM_000718.3|NM_001243812.1	NP_000709.1|NP_001230741.1	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	189					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TTCGACCTGCGAACACTGAGG	0.557000													17	37					0	0	1	0	0
ALKBH5	54890	broad.mit.edu	37	17	18088248	18088248	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr17:18088248A>G	ENST00000399138.4	+	1	696	c.691A>G	c.(691-693)Aag>Gag	p.K231E	ALKBH5_ENST00000541285.1_Intron	NM_017758.3	NP_060228.3	Q6P6C2	ALKB5_HUMAN	alkB, alkylation repair homolog 5 (E. coli)	231						integral to membrane	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(2)|ovary(1)|skin(1)	10	all_neural(463;0.228)					CTTCGGCTGCAAGTTCCAGTT	0.622000													27	36					0	0	1	0	0
IGKV5-2	28907	broad.mit.edu	37	2	89197141	89197141	+	RNA	SNP	A	A	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr2:89197141A>G	ENST00000390244.2	+	0	249																											AACCAGGAGAAGCTGCTATTT	0.448000													27	22					0	0	1	0	0
AC096579.13	0	broad.mit.edu	37	2	89160361	89160361	+	RNA	SNP	A	A	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr2:89160361A>G	ENST00000452230.1	-	0	39				AC096579.7_ENST00000430694.1_RNA																							CCAAATTTAAAACCTTATAAG	0.408000													7	8					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29625905	29625905	+	Missense_Mutation	SNP	T	T	C	rs137871677	by1000genomes	TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr20:29625905T>C	ENST00000278882.3	+	5	529	c.149T>C	c.(148-150)cTt>cCt	p.L50P	FRG1B_ENST00000439954.2_Missense_Mutation_p.L55P|FRG1B_ENST00000358464.4_Missense_Mutation_p.L50P														p.L50P(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGAAAATATCTTGGTATAAAT	0.333000													4	94					0	0	1	0	0
AC096579.13	0	broad.mit.edu	37	2	89160809	89160809	+	RNA	SNP	T	T	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr2:89160809T>G	ENST00000452230.1	-	0	39				AC096579.7_ENST00000430694.1_RNA																							TACAAAAACCTCCCTGAAAGC	0.403000													3	3					0	0	1	0	0
CLEC16A	23274	broad.mit.edu	37	16	11219835	11219835	+	Splice_Site	SNP	G	G	A			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr16:11219835G>A	ENST00000409790.1	+	22	2703		c.e22-1		CLEC16A_ENST00000409552.3_Splice_Site	NM_015226.2	NP_056041.1	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A									p.0?(1)		breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						TTTGACCGTAGCCCTCCTGGA	0.597000													78	96					0	0	1	0	0
IGKV4-1	28908	broad.mit.edu	37	2	89185474	89185474	+	RNA	SNP	G	G	C	rs142402063	by1000genomes	TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr2:89185474G>C	ENST00000390243.2	+	0	343																											CCAACAATAAGAACTACTTAG	0.537000													12	7					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	147743505	147743505	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chrX:147743505C>G	ENST00000370460.2	+	3	736	c.257C>G	c.(256-258)aCt>aGt	p.T86S	AFF2_ENST00000342251.3_Missense_Mutation_p.T82S|AFF2_ENST00000370457.5_Missense_Mutation_p.T82S|AFF2_ENST00000370458.1_Missense_Mutation_p.T82S	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	86					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					AATTTGCTAACTAACCATTCT	0.388000													83	27					0	0	1	0	0
CYP2D6	1565	broad.mit.edu	37	22	42524897	42524897	+	Silent	SNP	C	C	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr22:42524897C>G	ENST00000360608.5	-	4	669	c.555G>C	c.(553-555)gtG>gtC	p.V185V	CYP2D6_ENST00000359033.4_Silent_p.V134V|CYP2D6_ENST00000389970.3_Silent_p.V185V|NDUFA6-AS1_ENST00000439129.1_RNA|NDUFA6-AS1_ENST00000416037.2_RNA	NM_000106.5	NP_000097	Q6NWU0	Q6NWU0_HUMAN	cytochrome P450, family 2, subfamily D, polypeptide 6	185							electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(4)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GGGAGGCGATCACGTTGCTCA	0.667000													3	9					0	0	1	0	0
SYK	6850	broad.mit.edu	37	9	93637076	93637076	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr9:93637076G>T	ENST00000375754.4	+	9	1274	c.1126G>T	c.(1126-1128)Gaa>Taa	p.E376*	SYK_ENST00000375746.1_Nonsense_Mutation_p.E376*|SYK_ENST00000375751.4_Nonsense_Mutation_p.E353*|SYK_ENST00000375747.1_Nonsense_Mutation_p.E353*	NM_003177.5	NP_003168.2	P43405	KSYK_HUMAN	spleen tyrosine kinase	376	Protein kinase.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)|skin(2)|stomach(2)	26						GGAAGACAAAGAACTGGGCTC	0.522000			T	"""ETV6, ITK"""	"""MDS, peripheral T-cell lymphoma"""								51	95					1.05386e-31	1.07799e-31	1	1	0
LMNB2	84823	broad.mit.edu	37	19	2438182	2438182	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr19:2438182G>C	ENST00000325327.3	-	4	725	c.663C>G	c.(661-663)ttC>ttG	p.F221L	LMNB2_ENST00000582871.1_Missense_Mutation_p.F201L			Q03252	LMNB2_HUMAN	lamin B2	201	Linker 2.|Rod.					nuclear inner membrane	structural molecule activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACTCTTCCGGAAGTCCAGCT	0.617000													21	31					0	0	1	0	0
IGLV7-46	28775	broad.mit.edu	37	22	22724431	22724431	+	RNA	SNP	C	C	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr22:22724431C>G	ENST00000390295.2	+	0	361																											AGTATTACTGCTTGCTCTCCT	0.567000													9	25					0	0	1	0	0
IGLV4-3	28786	broad.mit.edu	37	22	23213919	23213919	+	RNA	SNP	C	C	T			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr22:23213919C>T	ENST00000390318.2	+	0	108																											GCTGACTCAGCCCCCGTCTGC	0.532000													34	19					0	0	1	0	0
ALKBH5	54890	broad.mit.edu	37	17	18088080	18088080	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr17:18088080A>G	ENST00000399138.4	+	1	528	c.523A>G	c.(523-525)Aag>Gag	p.K175E	ALKBH5_ENST00000541285.1_Intron	NM_017758.3	NP_060228.3	Q6P6C2	ALKB5_HUMAN	alkB, alkylation repair homolog 5 (E. coli)	175						integral to membrane	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(2)|ovary(1)|skin(1)	10	all_neural(463;0.228)					GGTGATCCAAAAGCTGGTGGA	0.687000													11	29					0	0	1	0	0
SEC23A	10484	broad.mit.edu	37	14	39534130	39534130	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr14:39534130C>T	ENST00000537403.1	-	7	1891	c.689G>A	c.(688-690)tGt>tAt	p.C230Y	SEC23A_ENST00000545328.2_Missense_Mutation_p.C403Y|SEC23A_ENST00000536508.1_Missense_Mutation_p.C306Y|SEC23A_ENST00000553925.1_5'UTR|SEC23A_ENST00000307712.6_Missense_Mutation_p.C432Y			Q15436	SC23A_HUMAN	Sec23 homolog A (S. cerevisiae)	432					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			kidney(2)|large_intestine(3)|liver(1)|lung(11)|ovary(4)|pancreas(1)|upper_aerodigestive_tract(1)	23	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)		TTCAGACACACAGGGTCCTTT	0.423000													23	53					0	0	1	0	0
C7	730	broad.mit.edu	37	5	40972561	40972561	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr5:40972561C>G	ENST00000313164.9	+	15	2298	c.1939C>G	c.(1939-1941)Cct>Gct	p.P647A		NM_000587.2	NP_000578.2	P10643	CO7_HUMAN	complement component 7	647	Sushi 2.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex							Ovarian(839;0.0112)				CCCCCAAAAACCTTTCTACAC	0.453000													28	50					0	0	1	0	0
BOD1L1	259282	broad.mit.edu	37	4	13602997	13602997	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr4:13602997A>T	ENST00000040738.5	-	10	5662	c.5527T>A	c.(5527-5529)Tta>Ata	p.L1843I		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	1843							DNA binding										GCAGCAACTAATGGTACATTA	0.473000													25	30					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70333403	70333403	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr11:70333403C>G	ENST00000338508.4	-	32	2997	c.2998G>C	c.(2998-3000)Gcc>Ccc	p.A1000P	SHANK2_ENST00000449833.2_Missense_Mutation_p.A404P|SHANK2_ENST00000409161.1_Missense_Mutation_p.A403P|SHANK2_ENST00000423696.2_Missense_Mutation_p.A620P			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	620					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			ACGTAGACGGCTTTGCTGGCG	0.617000													54	79					0	0	1	0	0
IGLV3-1	28809	broad.mit.edu	37	22	23223523	23223523	+	RNA	SNP	C	C	T			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr22:23223523C>T	ENST00000390319.2	+	0	345																											GGGACCCAGGCTATGGATGAG	0.572000													16	9					0	0	1	0	0
ZC2HC1C	79696	broad.mit.edu	37	14	75538463	75538463	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr14:75538463G>A	ENST00000524913.1	+	2	1676	c.1187G>A	c.(1186-1188)cGc>cAc	p.R396H	ZC2HC1C_ENST00000439583.2_Intron|ZC2HC1C_ENST00000238686.8_Intron|ZC2HC1C_ENST00000526748.1_Intron	NM_024643.2	NP_078919.2	Q53FD0	F164C_HUMAN	zinc finger, C2HC-type containing 1C	0																	CACTGTGGGCGCAAATTCCTC	0.587000													3	29					0	0	1	0	0
EPRS	2058	broad.mit.edu	37	1	220179552	220179552	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr1:220179552C>T	ENST00000366923.3	-	15	2115	c.1846G>A	c.(1846-1848)Gct>Act	p.A616T		NM_004446.2	NP_004437.2	P07814	SYEP_HUMAN	glutamyl-prolyl-tRNA synthetase	616	Glutamyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			breast(2)|endometrium(11)|kidney(2)|large_intestine(13)|lung(24)|ovary(1)|prostate(3)|skin(2)|stomach(2)|urinary_tract(3)	63				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	ATAGGAAGAGCATGTGTAGTC	0.398000													46	109					0	0	1	0	0
FBF1	85302	broad.mit.edu	37	17	73929085	73929085	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr17:73929085G>A	ENST00000586717.1	-	4	389	c.116C>T	c.(115-117)gCg>gTg	p.A39V	FBF1_ENST00000319129.5_Missense_Mutation_p.A39V|FBF1_ENST00000389570.4_Missense_Mutation_p.A39V			A6NLR5	A6NLR5_HUMAN	Fas (TNFRSF6) binding factor 1	39										large_intestine(2)|ovary(1)|upper_aerodigestive_tract(1)	4						CTTTGTTCTCGCCTTTGAAGA	0.468000													4	28					0	0	1	0	0
BCL11A	53335	broad.mit.edu	37	2	60780359	60780359	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr2:60780359T>G	ENST00000335712.6	-	1	274	c.47A>C	c.(46-48)gAa>gCa	p.E16A	BCL11A_ENST00000359629.5_Missense_Mutation_p.E16A|BCL11A_ENST00000356842.4_Missense_Mutation_p.E16A|BCL11A_ENST00000538214.1_Missense_Mutation_p.E16A|BCL11A_ENST00000358510.4_Missense_Mutation_p.E16A|BCL11A_ENST00000537768.1_5'UTR	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	16	Required for nuclear body formation and for SUMO1 recruitment (By similarity).				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			ACGCGAGAATTCCCGTTTGCT	0.592000			T	IGH@	B-CLL								11	22					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104433030	104433030	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr9:104433030T>C	ENST00000361820.3	-	3	2264	c.1664A>G	c.(1663-1665)gAc>gGc	p.D555G		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	555					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	AAAAAGGCTGTCCAATGTGGA	0.453000													23	47					0	0	1	0	0
RBM17	84991	broad.mit.edu	37	10	6148184	6148184	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr10:6148184G>A	ENST00000446108.1	+	5	1132	c.488G>A	c.(487-489)cGa>cAa	p.R163Q	RBM17_ENST00000379888.4_Missense_Mutation_p.R163Q	NM_001145547.1	NP_001139019.1	Q96I25	SPF45_HUMAN	RNA binding motif protein 17	163					mRNA processing|RNA splicing	spliceosomal complex	nucleotide binding|protein binding|RNA binding			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(2)	19						GATTATGAGCGAGAGAGGAGG	0.368000													18	35					0	0	1	0	0
BBS9	27241	broad.mit.edu	37	7	33427661	33427661	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr7:33427661C>T	ENST00000242067.6	+	19	2541	c.2020C>T	c.(2020-2022)Cgg>Tgg	p.R674W	BBS9_ENST00000396127.2_Missense_Mutation_p.R639W|BBS9_ENST00000355070.2_Missense_Mutation_p.R669W|BBS9_ENST00000350941.3_Missense_Mutation_p.R634W|BBS9_ENST00000354265.4_Missense_Mutation_p.R639W	NM_198428.2	NP_940820.1	Q3SYG4	PTHB1_HUMAN	Bardet-Biedl syndrome 9	674					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding		BBS9/PKD1L1(2)	NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	50			GBM - Glioblastoma multiforme(11;0.0894)			TGTACAATTTCGGGCCATTCA	0.403000									Bardet-Biedl syndrome				55	84					0	0	1	0	0
LRRC4C	57689	broad.mit.edu	37	11	40137458	40137458	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr11:40137458G>C	ENST00000278198.2	-	2	2348	c.385C>G	c.(385-387)Ctg>Gtg	p.L129V	LRRC4C_ENST00000530763.1_Missense_Mutation_p.L129V|LRRC4C_ENST00000527150.1_Missense_Mutation_p.L129V|LRRC4C_ENST00000528697.1_Missense_Mutation_p.L129V			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	129					regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				AAGAGTTCCAGAGTGTTGAGG	0.438000													15	35					0	0	1	0	0
IGLV3-1	28809	broad.mit.edu	37	22	23223511	23223511	+	RNA	SNP	G	G	C			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr22:23223511G>C	ENST00000390319.2	+	0	333																											CTGACCATCAGCGGGACCCAG	0.567000													15	11					0	0	1	0	0
PIK3CD	5293	broad.mit.edu	37	1	9775912	9775912	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr1:9775912C>G	ENST00000536656.1	+	5	584	c.376C>G	c.(376-378)Cac>Gac	p.H126D	PIK3CD_ENST00000361110.2_Missense_Mutation_p.H126D|PIK3CD_ENST00000377346.4_Missense_Mutation_p.H126D			O00329	PK3CD_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	126					phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(12)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		CGCAGGCCTCCACGAGTTTGA	0.687000													9	11					0	0	1	0	0
IGLC3	3539	broad.mit.edu	37	22	23248700	23248700	+	RNA	SNP	A	A	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr22:23248700A>G	ENST00000390325.2	+	0	189																											ACAAAGCAACAACAAGTACGC	0.602000													11	22					0	0	1	0	0
SLC2A8	29988	broad.mit.edu	37	9	130166057	130166057	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr9:130166057C>G	ENST00000373371.3	+	6	931	c.842C>G	c.(841-843)aCc>aGc	p.T281S	SLC2A8_ENST00000373352.1_Missense_Mutation_p.T18S|SLC2A8_ENST00000373360.3_Missense_Mutation_p.T281S	NM_001271712.1|NM_014580.3	NP_001258641.1|NP_055395.2	Q9NY64	GTR8_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 8	281						cytoplasmic vesicle membrane|integral to plasma membrane	D-glucose transmembrane transporter activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)	11						TATGCAGAGACCATCTTTGAA	0.612000													6	15					0	0	1	0	0
DAGLB	221955	broad.mit.edu	37	7	6465739	6465739	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr7:6465739T>G	ENST00000297056.6	-	7	1105	c.936A>C	c.(934-936)agA>agC	p.R312S	DAGLB_ENST00000436575.1_Missense_Mutation_p.R271S|DAGLB_ENST00000421761.2_Missense_Mutation_p.R56S|DAGLB_ENST00000428902.2_Missense_Mutation_p.R185S|DAGLB_ENST00000425398.2_Missense_Mutation_p.R183S	NM_139179.3	NP_631918.3	Q8NCG7	DGLB_HUMAN	diacylglycerol lipase, beta	312					lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|urinary_tract(2)	26		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)		TGGTTCTGCTTCTGCAGCTAA	0.542000													38	93					0	0	1	0	0
APOBEC3F	200316	broad.mit.edu	37	22	39441047	39441047	+	Silent	SNP	A	A	C			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr22:39441047A>C	ENST00000308521.5	+	3	630	c.273A>C	c.(271-273)gtA>gtC	p.V91V	APOBEC3F_ENST00000491387.1_3'UTR|APOBEC3G_ENST00000452957.2_Intron	NM_145298.5	NP_660341.2	Q9HC16	ABC3G_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F	92					base conversion or substitution editing|DNA cytosine deamination|innate immune response|interspecies interaction between organisms|negative regulation of retroviral genome replication|negative regulation of transposition|positive regulation of defense response to virus by host|response to virus|viral reproduction	apolipoprotein B mRNA editing enzyme complex|cytosol|mitochondrion	cytidine deaminase activity|dCTP deaminase activity|protein homodimerization activity|RNA binding|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|skin(2)	16	Melanoma(58;0.04)					CCTGGTTTGTATCCTGGACCC	0.577000													49	33					0	0	1	0	0
SEMA3E	9723	broad.mit.edu	37	7	82997071	82997071	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr7:82997071C>G	ENST00000307792.3	-	17	2626	c.2159G>C	c.(2158-2160)aGc>aCc	p.S720T	SEMA3E_ENST00000427262.1_Missense_Mutation_p.S660T	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	720					axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				CTGGAAGTTGCTATAACCGAT	0.473000													40	134					0	0	1	0	0
IGHV3-21	28444	broad.mit.edu	37	14	106692118	106692118	+	RNA	SNP	G	G	C			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr14:106692118G>C	ENST00000390607.2	-	0	85																											CGGAGCCCCAGTTCCATGGTG	0.502000													12	35					0	0	1	0	0
IGLV7-43	28776	broad.mit.edu	37	22	22749617	22749617	+	RNA	SNP	A	A	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr22:22749617A>G	ENST00000390298.2	+	0	175																											GCACTGGAGCAGTCACCAGTG	0.532000													9	28					0	0	1	0	0
DNMBP	23268	broad.mit.edu	37	10	101648614	101648614	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr10:101648614G>A	ENST00000342239.3	-	12	3416	c.3325C>T	c.(3325-3327)Cgc>Tgc	p.R1109C	DNMBP_ENST00000472036.1_5'UTR|DNMBP_ENST00000324109.4_Missense_Mutation_p.R1085C|DNMBP_ENST00000543621.1_Missense_Mutation_p.R331C|DNMBP_ENST00000540316.1_Missense_Mutation_p.R21C			Q6XZF7	DNMBP_HUMAN	dynamin binding protein	1085	BAR.				intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(4)|endometrium(9)|large_intestine(14)|lung(19)|ovary(5)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	61		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		CTGATGTAGCGATGCACCCTC	0.507000													21	30					0	0	1	0	0
CNST	163882	broad.mit.edu	37	1	246823529	246823529	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr1:246823529T>C	ENST00000366513.4	+	10	2134	c.1865T>C	c.(1864-1866)aTa>aCa	p.I622T		NM_152609.2	NP_689822.2	Q6PJW8	CNST_HUMAN	consortin, connexin sorting protein	622					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|urinary_tract(2)	28						TTGGTCTCCATATTAAAGAAG	0.383000													98	79					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117710315	117710315	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr12:117710315C>T	ENST00000317775.6	-	10	2399	c.1714G>A	c.(1714-1716)Gtg>Atg	p.V572M	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Missense_Mutation_p.V572M	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	572					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding	p.V572M(1)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	ATGTTGGACACGGCGGGGAGG	0.617000													16	51					0	0	1	0	0
IGKV5-2	28907	broad.mit.edu	37	2	89197076	89197076	+	RNA	SNP	A	A	C			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr2:89197076A>C	ENST00000390244.2	+	0	184																											CAAAGTCAACATCTCCTGCAA	0.428000													19	11					0	0	1	0	0
ZFP36L1	677	broad.mit.edu	37	14	69259601	69259601	+	Nonsense_Mutation	SNP	T	T	A			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr14:69259601T>A	ENST00000439696.2	-	1	356	c.55A>T	c.(55-57)Aag>Tag	p.K19*	ZFP36L1_ENST00000336440.3_Nonsense_Mutation_p.K19*	NM_001244701.1|NM_004926.3	NP_001231630.1|NP_004917.2	Q07352	TISB_HUMAN	ZFP36 ring finger protein-like 1	19					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|kidney(1)|large_intestine(1)|liver(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(1)	21				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		CCCTTTACCTTGCATAAAACT	0.517000													73	79					0	0	1	0	0
SLC6A15	55117	broad.mit.edu	37	12	85255517	85255517	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr12:85255517C>T	ENST00000266682.5	-	12	2628	c.2087G>A	c.(2086-2088)cGa>cAa	p.R696Q	SLC6A15_ENST00000552192.1_Missense_Mutation_p.R589Q|SLC6A15_ENST00000309283.7_3'UTR	NM_182767.5	NP_877499.1	Q9H2J7	S6A15_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 15	696					cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						ACTCTGTTTTCGATAAATATT	0.433000													96	67					0	0	1	0	0
ADCY6	112	broad.mit.edu	37	12	49177118	49177118	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr12:49177118G>C	ENST00000307885.4	-	1	794	c.100C>G	c.(100-102)Cgg>Ggg	p.R34G	ADCY6_ENST00000550422.1_Missense_Mutation_p.R34G|ADCY6_ENST00000357869.3_Missense_Mutation_p.R34G	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	34					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						CCACCTGCCCGAGTGCCACGG	0.657000													20	19					0	0	1	0	0
DMRTB1	63948	broad.mit.edu	37	1	53927225	53927225	+	Silent	SNP	G	G	A			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr1:53927225G>A	ENST00000371445.3	+	2	712	c.657G>A	c.(655-657)ccG>ccA	p.P219P	DMRTB1_ENST00000463126.1_3'UTR	NM_033067.1	NP_149056.1	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal, 1	219	Pro-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(3)|lung(5)|ovary(1)|skin(1)	10						CCTACTGCCCGTTCCCGCTGG	0.657000													24	45					0	0	1	0	0
KRTAP5-8	57830	broad.mit.edu	37	11	71249545	71249545	+	Silent	SNP	C	C	T			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr11:71249545C>T	ENST00000398534.3	+	1	475	c.444C>T	c.(442-444)tgC>tgT	p.C148C		NM_021046.2	NP_066384.2	O75690	KRA58_HUMAN	keratin associated protein 5-8	148	9 X 4 AA repeats of C-C-X-P.					extracellular region|keratin filament	structural constituent of epidermis			cervix(1)|endometrium(1)|lung(2)|skin(1)|stomach(1)	6						AGTCCAGCTGCTGTAAGCCCT	0.607000													5	234					0	0	1	0	0
ZNF70	7621	broad.mit.edu	37	22	24086730	24086730	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr22:24086730C>G	ENST00000341976.3	-	2	1058	c.598G>C	c.(598-600)Gag>Cag	p.E200Q		NM_021916.2	NP_068735.1	Q9UC06	ZNF70_HUMAN	zinc finger protein 70	200						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|urinary_tract(1)	21						TTCCCACACTCCCGGCACTCG	0.607000													17	15					0	0	1	0	0
C12orf55	144535	broad.mit.edu	37	12	97051849	97051849	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr12:97051849G>C	ENST00000524981.4	+	37	5313	c.5290G>C	c.(5290-5292)Gta>Cta	p.V1764L						chromosome 12 open reading frame 55																		GGAAACACTAGTATCTCTTGC	0.323000													48	31					0	0	1	0	0
OR5H14	403273	broad.mit.edu	37	3	97868649	97868649	+	Silent	SNP	G	G	A	rs142399115	byFrequency	TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr3:97868649G>A	ENST00000437310.1	+	1	480	c.420G>A	c.(418-420)ctG>ctA	p.L140L		NM_001005514.1	NP_001005514.1	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H, member 14	140					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						CCAATGGACTGTGCATCCGGC	0.393000													9	199					0	0	1	0	0
LRRC56	115399	broad.mit.edu	37	11	554045	554045	+	Silent	SNP	G	G	A			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr11:554045G>A	ENST00000270115.7	+	14	1898	c.1398G>A	c.(1396-1398)ccG>ccA	p.P466P		NM_198075.3	NP_932341.1	Q8IYG6	LRC56_HUMAN	leucine rich repeat containing 56	466										kidney(1)|lung(4)|skin(1)	6		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCAGCTCCCCGCGGTGGTCGA	0.672000													30	42					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145293471	145293471	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr1:145293471G>C	ENST00000342960.5	+	1	101	c.66G>C	c.(64-66)gaG>gaC	p.E22D	RP11-458D21.5_ENST00000468030.1_3'UTR|NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.3_Missense_Mutation_p.E22D	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	22										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AAATCAACGAGACATTGCGCC	0.517000													90	1049					0	0	1	0	0
BMP7	655	broad.mit.edu	37	20	55840815	55840815	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr20:55840815G>A	ENST00000395863.3	-	1	869	c.364C>T	c.(364-366)Caa>Taa	p.Q122*	BMP7_ENST00000395864.3_Nonsense_Mutation_p.Q122*|BMP7_ENST00000450594.2_Nonsense_Mutation_p.Q122*	NM_001719.2	NP_001710.1	P18075	BMP7_HUMAN	bone morphogenetic protein 7	122					BMP signaling pathway|cartilage development|cellular response to hypoxia|epithelial to mesenchymal transition|growth|mesonephros development|negative regulation of glomerular mesangial cell proliferation|negative regulation of MAP kinase activity|negative regulation of mitosis|negative regulation of neuron differentiation|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of phosphorylation|negative regulation of striated muscle cell apoptosis|negative regulation of transcription, DNA-dependent|ossification|pathway-restricted SMAD protein phosphorylation|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|protein localization to nucleus|regulation of removal of superoxide radicals|SMAD protein signal transduction|steroid hormone mediated signaling pathway|ureteric bud development	extracellular space	cytokine activity|growth factor activity			endometrium(4)|kidney(1)|large_intestine(7)|lung(6)|prostate(1)|skin(1)	20	all_lung(29;0.0133)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;2.49e-13)|Epithelial(14;1.74e-08)|all cancers(14;2.05e-07)			TGGCTATCTTGCAGGCTGGCC	0.662000													7	6					0	0	1	0	0
SLC9B2	133308	broad.mit.edu	37	4	103988643	103988643	+	Missense_Mutation	SNP	G	G	A	rs142037979		TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr4:103988643G>A	ENST00000394785.3	-	2	696	c.65C>T	c.(64-66)aCg>aTg	p.T22M	SLC9B2_ENST00000362026.3_Missense_Mutation_p.T22M|SLC9B2_ENST00000503103.1_Missense_Mutation_p.T22M|SLC9B2_ENST00000339611.4_Missense_Mutation_p.T22M|SLC9B2_ENST00000505838.1_5'UTR|SLC9B2_ENST00000503230.1_Missense_Mutation_p.T22M	NM_178833.4	NP_849155.2	Q86UD5	NHDC2_HUMAN	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2	22					sodium ion transport	integral to membrane|mitochondrial membrane	solute:hydrogen antiporter activity										CATGGAGGGCGTGTAATTCAT	0.368000													27	56					0	0	1	0	0
C4BPB	725	broad.mit.edu	37	1	207271519	207271519	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr1:207271519G>C	ENST00000243611.5	+	5	822	c.528G>C	c.(526-528)gaG>gaC	p.E176D	C4BPB_ENST00000367076.3_Missense_Mutation_p.E175D|C4BPB_ENST00000470767.1_3'UTR|C4BPB_ENST00000367078.3_Missense_Mutation_p.E176D|C4BPB_ENST00000391923.1_Missense_Mutation_p.E176D	NM_000716.3	NP_000707.1	P20851	C4BPB_HUMAN	complement component 4 binding protein, beta	176	Sushi 3.				blood coagulation|complement activation, classical pathway|innate immune response	extracellular region				breast(2)|lung(1)|ovary(1)	4						GCGTGCAGGAGCAGCAATGCG	0.473000													44	44					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	G	A	rs7266938	by1000genomes	TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr20:29625877G>A	ENST00000278882.3	+	5	501	c.121G>A	c.(121-123)Gcc>Acc	p.A41T	FRG1B_ENST00000439954.2_Missense_Mutation_p.A46T|FRG1B_ENST00000358464.4_Missense_Mutation_p.A41T														p.A41T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTACAGAATCGCCCTGAAATC	0.358000													4	83					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52320896	52320896	+	Silent	SNP	C	C	A			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr8:52320896C>A	ENST00000356297.4	-	17	3388	c.3288G>T	c.(3286-3288)ggG>ggT	p.G1096G	PXDNL_ENST00000543296.1_Silent_p.G1096G	NM_144651.4	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	1096					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CCGGGTCTATCCCACCTTCCT	0.552000													26	29					1.85244e-09	1.88051e-09	1	1	0
SYCP1	6847	broad.mit.edu	37	1	115537600	115537601	+	Frame_Shift_Ins	INS	-	-	A			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr1:115537600_115537601insA	ENST00000369522.3	+	32	3131_3132	c.2891_2892insA	c.(2890-2895)agaaaafs	p.RK964fs	SYCP1_ENST00000369518.1_Frame_Shift_Ins_p.RK964fs|SYCP1_ENST00000477590.1_3'UTR	NM_001282541.1|NM_003176.2	NP_001269470.1|NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	964	Arg/Lys-rich (basic).				cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAAATGGATAGAAAAAAAAAAC	0.356													9	68	---	---	---	---					
PYCRL	65263	broad.mit.edu	37	8	144688646	144688651	+	In_Frame_Del	DEL	GCCACT	GCCACT	-			TCGA-DK-AA6T-01A-11D-A391-08	TCGA-DK-AA6T-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db9a3743-9af2-4153-9c8c-e0f8d9f22326	dfc5766d-eeb3-49c0-9a53-0488c3d26921	g.chr8:144688646_144688651delGCCACT	ENST00000220966.6	-	4	600_605	c.571_576delAGTGGC	c.(571-576)agtggcdel	p.SG191del	PYCRL_ENST00000495276.1_5'UTR|PYCRL_ENST00000377579.3_In_Frame_Del_p.SG42del	NM_023078.3	NP_075566.2	Q53H96	P5CR3_HUMAN	pyrroline-5-carboxylate reductase-like	179					proline biosynthetic process		pyrroline-5-carboxylate reductase activity			central_nervous_system(1)|endometrium(1)|lung(2)|ovary(1)	5	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.17e-38)|Epithelial(56;7.17e-37)|all cancers(56;2.46e-32)|Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			CGAAGGCCACGCCACTGCCACTGAGG	0.650													9	46	---	---	---	---					
