Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CHD4	1108	broad.mit.edu	37	12	6705294	6705294	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr12:6705294C>G	ENST00000309577.6	-	13	2065	c.1902G>C	c.(1900-1902)aaG>aaC	p.K634N	CHD4_ENST00000357008.2_Missense_Mutation_p.K634N|CHD4_ENST00000544040.1_Missense_Mutation_p.K627N|CHD4_ENST00000544484.1_Missense_Mutation_p.K631N			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	634	Chromo 2.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						CGTGGCCCTTCTTGTCCACAC	0.507000													27	65					0	0	0.717897	0	0
FAM208B	54906	broad.mit.edu	37	10	5798670	5798670	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr10:5798670G>A	ENST00000328090.5	+	16	7326	c.6701G>A	c.(6700-6702)aGa>aAa	p.R2234K		NM_017782.4	NP_060252	Q5VWN6	CJ018_HUMAN	family with sequence similarity 208, member B	2234																	ATCATCATCAGAAATGAAGAT	0.393000													25	46					0	0	0.693898	0	0
OR5W2	390148	broad.mit.edu	37	11	55681259	55681259	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:55681259G>A	ENST00000344514.1	-	1	799	c.800C>T	c.(799-801)tCt>tTt	p.S267F		NM_001001960.1	NP_001001960.1	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W, member 2	267					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(28)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						TTGATCTAGAGAATAGGAAGA	0.438000													6	36					0	0	0.217242	0	0
LRRC37A3	374819	broad.mit.edu	37	17	62893332	62893332	+	Missense_Mutation	SNP	G	G	C	rs4080904		TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:62893332G>C	ENST00000584306.1	-	3	574	c.44C>G	c.(43-45)cCg>cGg	p.P15R	RP11-927P21.1_ENST00000584959.1_RNA|LRRC37A3_ENST00000339474.5_Intron|RP11-927P21.1_ENST00000584131.1_RNA|LRRC37A3_ENST00000400877.3_Intron|LRRC37A3_ENST00000319651.5_Missense_Mutation_p.P15R	NM_199340.2	NP_955372.2	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	15						integral to membrane				NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|liver(1)|lung(10)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						GAAACGCAGCGGGGACATGAC	0.602000													4	223					0	0	0.278610	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74649182	74649182	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:74649182T>C	ENST00000354431.4	-	2	378	c.187A>G	c.(187-189)Aca>Gca	p.T63A	LRRIQ3_ENST00000395089.1_Missense_Mutation_p.T63A|LRRIQ3_ENST00000370909.2_Missense_Mutation_p.T63A|LRRIQ3_ENST00000370911.3_Missense_Mutation_p.T63A	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	63										NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						TGAATATCTGTAATAAaattg	0.308000													16	18					0	0	0.557998	0	0
HSD17B1	3292	broad.mit.edu	37	17	40705230	40705230	+	Silent	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:40705230G>A	ENST00000585807.1	+	2	3906	c.186G>A	c.(184-186)acG>acA	p.T62T	RP11-400F19.8_ENST00000585572.1_RNA|RP11-400F19.6_ENST00000590513.1_RNA|HSD17B1_ENST00000225929.5_Silent_p.T62T	NM_000413.2	NP_000404.2	P14061	DHB1_HUMAN	hydroxysteroid (17-beta) dehydrogenase 1	62					estrogen biosynthetic process	cytosol	binding|estradiol 17-beta-dehydrogenase activity			NS(1)|endometrium(1)|kidney(1)|lung(2)	5		all_cancers(22;5.59e-08)|all_epithelial(22;7e-07)|Ovarian(249;0.0261)		BRCA - Breast invasive adenocarcinoma(366;0.129)	NADH(DB00157)	CCCTGGAGACGTTGCAGCTGG	0.647000													37	77					0	0	0.870114	0	0
KRT80	144501	broad.mit.edu	37	12	52574698	52574698	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr12:52574698G>A	ENST00000313234.5	-	3	656	c.559C>T	c.(559-561)Cag>Tag	p.Q187*	KRT80_ENST00000394815.2_Nonsense_Mutation_p.Q187*	NM_001081492.1	NP_001074961.1	Q6KB66	K2C80_HUMAN	keratin 80	187	Coil 1B.|Rod.					keratin filament	structural molecule activity			endometrium(2)|large_intestine(2)|lung(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.108)		TTCTTCAGCTGAACAAAGGTG	0.582000													24	40					0	0	0.717897	0	0
KMT2C	58508	broad.mit.edu	37	7	151945127	151945127	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr7:151945127G>C	ENST00000355193.2	-	14	2610	c.2392C>G	c.(2392-2394)Cat>Gat	p.H798D	KMT2C_ENST00000262189.6_Missense_Mutation_p.H798D					lysine (K)-specific methyltransferase 2C																		GGGTAATTATGCAGCATGTCA	0.443000													25	552					0	0	0.796494	0	0
RELN	5649	broad.mit.edu	37	7	103202301	103202301	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr7:103202301C>T	ENST00000424685.2	-	35	5469	c.5310G>A	c.(5308-5310)tgG>tgA	p.W1770*	RELN_ENST00000343529.5_Nonsense_Mutation_p.W1770*|RELN_ENST00000428762.1_Nonsense_Mutation_p.W1770*			P78509	RELN_HUMAN	reelin	1770	EGF-like 4.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTGAGCACATCCAAGGGCACC	0.473000													30	48					0	0	0.834066	0	0
ZNF257	113835	broad.mit.edu	37	19	22271465	22271465	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr19:22271465C>T	ENST00000594947.1	+	4	1057	c.913C>T	c.(913-915)Caa>Taa	p.Q305*		NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	305					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				TACCCTTACTCAACATAAGAG	0.393000													9	29					0	0	0.335167	0	0
OCLN	100506658	broad.mit.edu	37	5	68805036	68805036	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr5:68805036C>G	ENST00000355237.2	+	3	555	c.119C>G	c.(118-120)tCt>tGt	p.S40C	OCLN_ENST00000380766.2_Missense_Mutation_p.S40C|OCLN_ENST00000538151.1_Intron|OCLN_ENST00000542132.1_Intron|OCLN_ENST00000396442.2_Missense_Mutation_p.S40C	NM_002538.3	NP_002529.1	Q16625	OCLN_HUMAN	occludin	40					cellular component disassembly involved in apoptosis|protein complex assembly	integral to membrane|tight junction	protein binding|structural molecule activity			endometrium(2)|large_intestine(1)|liver(1)|prostate(1)|skin(1)	6		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		CCAATGCTCTCTCAGCCAGCC	0.403000													36	81					0	0	0.804634	0	0
PIM3	415116	broad.mit.edu	37	22	50356727	50356727	+	Silent	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr22:50356727C>G	ENST00000360612.4	+	6	1368	c.933C>G	c.(931-933)ctC>ctG	p.L311L		NM_001001852.3	NP_001001852.2	Q86V86	PIM3_HUMAN	pim-3 oncogene	311					cell cycle|negative regulation of apoptosis|regulation of mitotic cell cycle		ATP binding|protein binding|protein serine/threonine kinase activity						all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.196)|LUAD - Lung adenocarcinoma(64;0.247)		TGTGCACCCTCGACCCTGATG	0.677000													7	22					0	0	0.278610	0	0
DEPDC1	55635	broad.mit.edu	37	1	68949729	68949729	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:68949729C>G	ENST00000456315.2	-	7	928	c.814G>C	c.(814-816)Gaa>Caa	p.E272Q	DEPDC1_ENST00000370966.5_Missense_Mutation_p.E272Q	NM_001114120.1	NP_001107592.1	Q5TB30	DEP1A_HUMAN	DEP domain containing 1	272					intracellular signal transduction|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(397;7.21e-36)		ACATCTCGTTCAAATCCAACA	0.299000													9	29					0	0	0.435327	0	0
FRAS1	80144	broad.mit.edu	37	4	79462137	79462137	+	Silent	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:79462137G>A	ENST00000264895.6	+	74	12338	c.11898G>A	c.(11896-11898)gtG>gtA	p.V3966V		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3961					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						AGAAGAACGTGAATAGACACT	0.498000													6	98					0	0	0.278610	0	0
IGSF10	285313	broad.mit.edu	37	3	151161338	151161338	+	Silent	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:151161338C>G	ENST00000282466.3	-	5	5396	c.5397G>C	c.(5395-5397)gtG>gtC	p.V1799V		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	1799	Ig-like C2-type 4.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CGTCAACCGTCACCACAGCCT	0.512000													22	45					0	0	0.667858	0	0
ZNF646	9726	broad.mit.edu	37	16	31090309	31090309	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr16:31090309G>C	ENST00000394979.2	+	1	3087	c.2664G>C	c.(2662-2664)atG>atC	p.M888I	ZNF646_ENST00000300850.5_Missense_Mutation_p.M888I			O15015	ZN646_HUMAN	zinc finger protein 646	888					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(1)|lung(21)|ovary(1)|prostate(4)|skin(3)	49						TCTGTGGCATGATCTTCCCTG	0.637000													16	59					0	0	0.520397	0	0
TRPV2	51393	broad.mit.edu	37	17	16326850	16326850	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:16326850C>A	ENST00000338560.7	+	5	1092	c.693C>A	c.(691-693)aaC>aaA	p.N231K	TRPV2_ENST00000577397.1_Intron	NM_016113.4	NP_057197.2	Q9Y5S1	TRPV2_HUMAN	transient receptor potential cation channel, subfamily V, member 2	231	Required for interaction with SLC50A1 (By similarity).				sensory perception	integral to plasma membrane|melanosome	calcium channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|stomach(3)	28				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TCCTGGAGAACCCACACCAGC	0.607000													37	56					7.53189e-24	8.26186e-24	0.834066	1	0
ZNF425	155054	broad.mit.edu	37	7	148801424	148801424	+	Silent	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr7:148801424G>A	ENST00000378061.2	-	4	1671	c.1539C>T	c.(1537-1539)ctC>ctT	p.L513L		NM_001001661.2	NP_001001661.1	Q6IV72	ZN425_HUMAN	zinc finger protein 425	513					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	50	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			GGTGCTGCGTGAGCCGCGACT	0.637000													9	33					0	0	0.435327	0	0
PGM2L1	283209	broad.mit.edu	37	11	74053678	74053678	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:74053678G>A	ENST00000298198.4	-	12	1771	c.1460C>T	c.(1459-1461)tCa>tTa	p.S487L		NM_173582.3	NP_775853.2	Q6PCE3	PGM2L_HUMAN	phosphoglucomutase 2-like 1	487					glucose 1-phosphate metabolic process	cytosol	glucose-1,6-bisphosphate synthase activity|phosphoglucomutase activity			NS(2)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	Breast(11;3.32e-06)					GGAAGTTTTTGAAATATGATA	0.289000													9	37					0	0	0.435327	0	0
PIK3CA	5290	broad.mit.edu	37	3	178928225	178928225	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:178928225C>G	ENST00000263967.3	+	9	1568	c.1411C>G	c.(1411-1413)Cca>Gca	p.P471A		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	471	C2 PI3K-type.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.P471A(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TTAGGAAACTCCATGCTTAGA	0.368000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			26	21					0	0	0.681144	0	0
AKAP1	8165	broad.mit.edu	37	17	55183156	55183156	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:55183156C>T	ENST00000337714.3	+	2	564	c.331C>T	c.(331-333)Ctt>Ttt	p.L111F	AKAP1_ENST00000572557.1_Missense_Mutation_p.L111F|AKAP1_ENST00000314126.3_Missense_Mutation_p.L111F|AKAP1_ENST00000539273.1_Missense_Mutation_p.L111F|AKAP1_ENST00000571629.1_Missense_Mutation_p.L111F	NM_003488.3	NP_003479.1	Q92667	AKAP1_HUMAN	A kinase (PRKA) anchor protein 1	111					blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			endometrium(2)|liver(1)|lung(7)|ovary(2)|pancreas(1)|skin(1)	14	Breast(9;5.46e-08)					CTCGGGCATTCTTCCTAACAC	0.547000													34	55					0	0	0.779181	0	0
NCAN	1463	broad.mit.edu	37	19	19339025	19339025	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr19:19339025G>A	ENST00000252575.6	+	8	2695	c.2596G>A	c.(2596-2598)Gat>Aat	p.D866N	NCAN_ENST00000538881.1_Missense_Mutation_p.D317N	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan						axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			GGTGGCCCTGGATACAAGCAT	0.597000													22	96					0	0	0.717897	0	0
UBBP4	23666	broad.mit.edu	37	17	21731270	21731270	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:21731270T>C	ENST00000584755.1	+	2	969	c.572T>C	c.(571-573)aTc>aCc	p.I191T	UBBP4_ENST00000578713.1_Intron|UBBP4_ENST00000583708.1_3'UTR														p.I191T(3)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						ATCCCCCCGATCAGCAGAGGC	0.547000													3	62					0	0	0.115264	0	0
FAT4	79633	broad.mit.edu	37	4	126241103	126241103	+	Silent	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126241103C>G	ENST00000394329.3	+	1	3550	c.3537C>G	c.(3535-3537)gtC>gtG	p.V1179V		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1179	Cadherin 11.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GCTTTACAGTCATAGCAACAG	0.428000													36	69					0	0	0.853193	0	0
FAT4	79633	broad.mit.edu	37	4	126239578	126239578	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126239578C>G	ENST00000394329.3	+	1	2025	c.2012C>G	c.(2011-2013)tCa>tGa	p.S671*		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	671	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CCCCAGTCATCAATGGCTCGC	0.488000													24	51					0	0	0.706142	0	0
CASP4	837	broad.mit.edu	37	11	104815563	104815563	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:104815563C>G	ENST00000444739.2	-	8	1961	c.1051G>C	c.(1051-1053)Gaa>Caa	p.E351Q	CASP4_ENST00000393150.3_Missense_Mutation_p.E295Q	NM_001225.3	NP_001216.1	P49662	CASP4_HUMAN	caspase 4, apoptosis-related cysteine peptidase	351					apoptosis|induction of apoptosis|proteolysis	intracellular	cysteine-type endopeptidase activity|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(2)	23		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000854)|Epithelial(105;0.00879)|all cancers(92;0.0357)		CTTGGAGTTTCAAATGATTGC	0.403000													5	27					0	0	0.248553	0	0
COL10A1	1300	broad.mit.edu	37	6	116442382	116442382	+	Silent	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr6:116442382C>T	ENST00000327673.4	-	2	1304	c.897G>A	c.(895-897)ggG>ggA	p.G299G	AL121963.1_ENST00000430695.1_Silent_p.F12F|COL10A1_ENST00000243222.4_Silent_p.G299G|NT5DC1_ENST00000319550.4_Intron			Q03692	COAA1_HUMAN	collagen, type X, alpha 1	299	Triple-helical region.				skeletal system development	collagen	metal ion binding			central_nervous_system(1)|endometrium(2)|lung(6)|skin(3)|upper_aerodigestive_tract(1)	13		all_cancers(87;0.0176)|all_epithelial(87;0.0263)|Colorectal(196;0.234)		all cancers(137;0.0157)|OV - Ovarian serous cystadenocarcinoma(136;0.0325)|GBM - Glioblastoma multiforme(226;0.0446)|Epithelial(106;0.0711)		AGCCTGGTTTCCCAAAGCCAG	0.642000													8	27					0	0	0.307466	0	0
CPA3	1359	broad.mit.edu	37	3	148596524	148596524	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:148596524T>C	ENST00000296046.3	+	5	515	c.463T>C	c.(463-465)Tat>Cat	p.Y155H	RP11-680B3.2_ENST00000488190.1_RNA	NM_001870.2	NP_001861.2	P15088	CBPA3_HUMAN	carboxypeptidase A3 (mast cell)	155					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			TAATCCACTATATGTTCTGAA	0.313000													16	17					0	0	0.557998	0	0
WDR75	84128	broad.mit.edu	37	2	190334854	190334854	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:190334854C>G	ENST00000314761.4	+	17	1932	c.1872C>G	c.(1870-1872)atC>atG	p.I624M		NM_032168.1	NP_115544.1	Q8IWA0	WDR75_HUMAN	WD repeat domain 75	624						nucleolus				breast(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.00105)|Epithelial(96;0.0129)|all cancers(119;0.0456)			AAAAGGGTATCTCCAGAGAGA	0.403000													47	87					0	0	0.870114	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367767	145367767	+	Missense_Mutation	SNP	G	G	A	rs77484671		TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:145367767G>A	ENST00000342960.5	+	83	10398	c.10363G>A	c.(10363-10365)Gaa>Aaa	p.E3455K	NBPF10_ENST00000369339.3_Intron|NBPF10_ENST00000369338.1_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3455								p.E3455K(5)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		atcaaagaaggaaagaagaag	0.423000													3	34					0	0	0.184627	0	0
HEXIM1	10614	broad.mit.edu	37	17	43227260	43227260	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:43227260G>T	ENST00000332499.2	+	1	2577	c.703G>T	c.(703-705)Gac>Tac	p.D235Y		NM_006460.2	NP_006451.1	O94992	HEXI1_HUMAN	hexamethylene bis-acetamide inducible 1	235	Autoinhibitory acidic region; in absence of 7SK snRNA interacts with the basic region preventing interaction with P-TEFb and modulating subcellular localization.				negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding			breast(1)|kidney(2)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						CAAATCCGACGACACCAGCGA	0.612000													14	73					1.37522e-17	1.48238e-17	0.557998	1	0
SLC32A1	140679	broad.mit.edu	37	20	37357147	37357147	+	Silent	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr20:37357147C>T	ENST00000217420.1	+	2	1706	c.1443C>T	c.(1441-1443)ctC>ctT	p.L481L		NM_080552.2	NP_542119.1	Q9H598	VIAAT_HUMAN	solute carrier family 32 (GABA vesicular transporter), member 1	481					neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|urinary_tract(1)	38		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	TGCGCCTGCTCTGGCGCAAGC	0.647000													5	70					0	0	0.217242	0	0
IGSF10	285313	broad.mit.edu	37	3	151166475	151166475	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:151166475C>G	ENST00000282466.3	-	4	1293	c.1294G>C	c.(1294-1296)Gac>Cac	p.D432H		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	432					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GAAATTTGGTCTTGCATTAAC	0.428000													13	22					0	0	0.479597	0	0
FGA	2243	broad.mit.edu	37	4	155506692	155506692	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:155506692C>T	ENST00000302053.3	-	5	1967	c.1889G>A	c.(1888-1890)aGa>aAa	p.R630K	FGA_ENST00000403106.3_Missense_Mutation_p.R630K	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	630	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	gtggatacctctgaCAGGGCG	0.488000													19	51					0	0	0.575678	0	0
GBA	2629	broad.mit.edu	37	1	155207361	155207361	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:155207361T>A	ENST00000327247.5	-	8	1002	c.770A>T	c.(769-771)gAt>gTt	p.D257V	GBA_ENST00000427500.3_Missense_Mutation_p.D208V|GBA_ENST00000428024.3_Missense_Mutation_p.D170V|GBA_ENST00000536770.1_Missense_Mutation_p.D144V|GBA_ENST00000368373.3_Missense_Mutation_p.D257V	NM_001005741.2|NM_001005742.2	NP_001005741.1|NP_001005742.1	P04062	GLCM_HUMAN	glucosidase, beta, acid	257					carbohydrate metabolic process|cell death|cellular response to tumor necrosis factor|ceramide biosynthetic process|glucosylceramide catabolic process|lysosome organization|negative regulation of interleukin-6 production|negative regulation of MAP kinase activity|positive regulation of protein dephosphorylation|sphingosine biosynthetic process|termination of signal transduction	lysosomal lumen|lysosomal membrane	cation binding|glucosylceramidase activity|receptor binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	26	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)		Alglucerase(DB00088)|Imiglucerase(DB00053)	AGCATAGGCATCCAGGAACCT	0.542000									Gaucher disease type I				9	13					0	0	0.575678	0	0
TAF1D	79101	broad.mit.edu	37	11	93471531	93471531	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:93471531G>T	ENST00000448108.2	-	3	853	c.203C>A	c.(202-204)tCa>tAa	p.S68*		NM_024116.3	NP_077021.1	Q9H5J8	TAF1D_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa	68					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding	p.S68L(1)		large_intestine(1)|lung(3)|prostate(1)|skin(2)	7						TTCAAAAGATGAGTCACTTGA	0.363000													4	23					0.150653	0.152491	0.150653	1	0
VEZF1	7716	broad.mit.edu	37	17	56056663	56056663	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:56056663C>T	ENST00000584396.1	-	5	1049	c.961G>A	c.(961-963)Gaa>Aaa	p.E321K	VEZF1_ENST00000581208.1_Missense_Mutation_p.E330K			Q14119	VEZF1_HUMAN	vascular endothelial zinc finger 1	330					cellular defense response|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|lung(5)|ovary(1)	10						CTGGTCTCTTCACTCATGCAT	0.443000													25	49					0	0	0.693898	0	0
FAT4	79633	broad.mit.edu	37	4	126240606	126240606	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126240606C>G	ENST00000394329.3	+	1	3053	c.3040C>G	c.(3040-3042)Cga>Gga	p.R1014G		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1014	Cadherin 10.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TGTGAATTCTCGATTCTTTAA	0.383000													27	61					0	0	0.706142	0	0
SPEG	10290	broad.mit.edu	37	2	220309874	220309874	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:220309874C>G	ENST00000312358.7	+	3	938	c.806C>G	c.(805-807)tCt>tGt	p.S269C	SPEG_ENST00000396698.1_Missense_Mutation_p.S165C|SPEG_ENST00000396695.2_Intron	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	269					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CGGGCGCTCTCTATCCACGTG	0.612000													3	8					0	0	0.115264	0	0
ENPP2	5168	broad.mit.edu	37	8	120620215	120620215	+	Silent	SNP	T	T	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr8:120620215T>C	ENST00000427067.2	-	9	948	c.768A>G	c.(766-768)ctA>ctG	p.L256L	ENPP2_ENST00000075322.6_Silent_p.L260L|ENPP2_ENST00000259486.6_Silent_p.L260L|ENPP2_ENST00000522826.1_Silent_p.L260L			Q13822	ENPP2_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 2	260					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(30)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)	69	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			CTGTAATCCATAGCTAATGAG	0.318000													15	12					0	0	0.539581	0	0
IGHV1-18	28468	broad.mit.edu	37	14	106641807	106641807	+	RNA	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr14:106641807G>A	ENST00000390605.2	-	0	165																											GACCTTCACTGAGGCCCCAGG	0.582000													56	49					0	0	0.870114	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64536627	64536627	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:64536627G>A	ENST00000498707.1	-	31	5152	c.4810C>T	c.(4810-4812)Cgt>Tgt	p.R1604C	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.R1576C	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	1604	TSP type-1 13.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.R1604C(1)		breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CAGCTTTCACGGTCCACCGGC	0.572000													111	113					0	0	0.870114	0	0
SEMA3F	6405	broad.mit.edu	37	3	50220147	50220147	+	Silent	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:50220147C>T	ENST00000002829.3	+	9	1318	c.834C>T	c.(832-834)ttC>ttT	p.F278F	SEMA3F_ENST00000413852.1_Silent_p.F179F|SEMA3F_ENST00000434342.1_Silent_p.F247F	NM_004186.3	NP_004177.3	Q13275	SEM3F_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	278	Sema.				axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(2)	17				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		TTTACTTCTTCTTCCGTGAGC	0.627000													47	75					0	0	0.870114	0	0
HECTD2	143279	broad.mit.edu	37	10	93252132	93252132	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr10:93252132G>C	ENST00000446394.1	+	14	1435	c.1335G>C	c.(1333-1335)ttG>ttC	p.L445F	HECTD2_ENST00000298068.5_Missense_Mutation_p.L441F|HECTD2_ENST00000371667.1_Missense_Mutation_p.L91F|HECTD2_ENST00000536715.1_Missense_Mutation_p.L30F	NM_001284274.1	NP_001271203.1	Q5U5R9	HECD2_HUMAN	HECT domain containing E3 ubiquitin protein ligase 2	441	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(10)|lung(7)|skin(1)|urinary_tract(1)	27						GAGCCGATTTGAAAAAGAAGT	0.348000													12	14					0	0	0.411799	0	0
NAALAD2	10003	broad.mit.edu	37	11	89885588	89885588	+	Silent	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:89885588G>A	ENST00000534061.1	+	6	962	c.732G>A	c.(730-732)caG>caA	p.Q244Q	NAALAD2_ENST00000321955.4_Silent_p.Q244Q|NAALAD2_ENST00000525171.1_Silent_p.Q244Q|NAALAD2_ENST00000375944.3_Silent_p.Q244Q	NM_005467.3	NP_005458.1	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	244					proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(32)|pancreas(1)|prostate(3)|skin(5)|stomach(2)	59		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				CTGCAGCCCAGAGAGGAAATG	0.473000													14	72					0	0	0.539581	0	0
WDR27	253769	broad.mit.edu	37	6	170013745	170013745	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr6:170013745G>A	ENST00000333572.6	-	22	2750	c.2231C>T	c.(2230-2232)tCa>tTa	p.S744L	WDR27_ENST00000448612.1_Missense_Mutation_p.S744L|WDR27_ENST00000546525.1_5'UTR|WDR27_ENST00000423258.1_Missense_Mutation_p.S617L			A2RRH5	WDR27_HUMAN	WD repeat domain 27	714										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)|skin(1)	12		Breast(66;1.53e-05)|Ovarian(120;0.216)		OV - Ovarian serous cystadenocarcinoma(33;6.48e-20)|BRCA - Breast invasive adenocarcinoma(81;3.56e-07)|GBM - Glioblastoma multiforme(31;0.00168)		GGTTGTAAATGATGAACCCTA	0.423000													4	24					0	0	0.184627	0	0
FBXO38	81545	broad.mit.edu	37	5	147821699	147821699	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr5:147821699G>A	ENST00000340253.5	+	22	3724	c.3556G>A	c.(3556-3558)Gac>Aac	p.D1186N	FBXO38_ENST00000296701.6_Missense_Mutation_p.D941N|FBXO38_ENST00000513826.1_Missense_Mutation_p.D941N|FBXO38_ENST00000394370.3_Missense_Mutation_p.D1111N			Q6PIJ6	FBX38_HUMAN	F-box protein 38	1186						cytoplasm|nucleus			ATG4C/FBXO38(2)	NS(1)|breast(2)|endometrium(7)|kidney(5)|large_intestine(9)|lung(15)|ovary(5)|prostate(2)|skin(2)|stomach(2)|urinary_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTTGAAGATGACTACATTTA	0.458000													12	80					0	0	0.435327	0	0
MARCH6	10299	broad.mit.edu	37	5	10390534	10390534	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr5:10390534G>C	ENST00000274140.5	+	6	630	c.498G>C	c.(496-498)caG>caC	p.Q166H	MARCH6_ENST00000449913.2_Missense_Mutation_p.Q118H|MARCH6_ENST00000503788.1_Missense_Mutation_p.Q61H	NM_005885.3	NP_005876.2	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase	166					protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(35)|ovary(1)|urinary_tract(3)	54						TGAGAGAGCAGATAGTCCATG	0.488000													42	143					0	0	0.870114	0	0
ULK4	54986	broad.mit.edu	37	3	41961238	41961238	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:41961238A>G	ENST00000301831.4	-	6	1076	c.614T>C	c.(613-615)tTg>tCg	p.L205S	ULK4_ENST00000420927.1_Missense_Mutation_p.L205S	NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4	205	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		CAGACAGCCCAAAGACCAGAG	0.413000													26	83					0	0	0.796494	0	0
YTHDC2	64848	broad.mit.edu	37	5	112917321	112917321	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr5:112917321C>A	ENST00000161863.4	+	25	3775	c.3562C>A	c.(3562-3564)Cct>Act	p.P1188T		NM_022828.3	NP_073739.3	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	1188							ATP binding|ATP-dependent helicase activity|nucleic acid binding			NS(2)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(13)|lung(10)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		AGAAGAGCTTCCTTTGGCCTC	0.403000													7	13					0.0293803	0.0301058	0.248553	1	0
MTFMT	123263	broad.mit.edu	37	15	65316099	65316099	+	Silent	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr15:65316099C>T	ENST00000220058.4	-	3	466	c.453G>A	c.(451-453)ccG>ccA	p.P151P	MTFMT_ENST00000561025.1_Intron	NM_139242.3	NP_640335.2	Q96DP5	FMT_HUMAN	mitochondrial methionyl-tRNA formyltransferase	151						mitochondrion	methionyl-tRNA formyltransferase activity|methyltransferase activity			endometrium(1)|large_intestine(3)|lung(3)|ovary(3)	10					Tetrahydrofolic acid(DB00116)	CACGCCATCTCGGGAGGCAAC	0.438000													5	13					0	0	0.184627	0	0
MON2	23041	broad.mit.edu	37	12	62986494	62986494	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr12:62986494C>G	ENST00000393630.3	+	36	5513	c.5122C>G	c.(5122-5124)Cca>Gca	p.P1708A	MON2_ENST00000552738.1_Missense_Mutation_p.P1678A|MON2_ENST00000393632.2_Missense_Mutation_p.P1707A|MON2_ENST00000551397.1_Missense_Mutation_p.P81A|MON2_ENST00000546600.1_3'UTR|MON2_ENST00000393629.2_Missense_Mutation_p.P1701A	NM_001278470.1|NM_001278472.1	NP_001265399.1|NP_001265401.1	Q7Z3U7	MON2_HUMAN	MON2 homolog (S. cerevisiae)	1708					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(15)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	57			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		TTTCATGCAGCCACCAGCATC	0.393000													23	42					0	0	0.706142	0	0
SLC1A1	6505	broad.mit.edu	37	9	4574009	4574009	+	Silent	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr9:4574009G>C	ENST00000262352.3	+	8	1106	c.870G>C	c.(868-870)ctG>ctC	p.L290L		NM_004170.5	NP_004161.4	P43005	EAA3_HUMAN	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	290					D-aspartate import|L-glutamate import|synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|pancreas(1)|skin(1)	15		Acute lymphoblastic leukemia(2;0.0359)|Breast(48;0.0457)		GBM - Glioblastoma multiforme(50;0.0124)|Lung(218;0.183)	L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)	CCACAGTCCTGACTGGGTATG	0.458000													44	47					0	0	0.859065	0	0
RIMS2	9699	broad.mit.edu	37	8	104897909	104897909	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr8:104897909G>A	ENST00000507740.1	+	2	742	c.506G>A	c.(505-507)cGa>cAa	p.R169Q	RIMS2_ENST00000262231.10_Missense_Mutation_p.R169Q|RIMS2_ENST00000522174.1_3'UTR|RIMS2_ENST00000436393.2_Missense_Mutation_p.R139Q|RIMS2_ENST00000406091.3_Missense_Mutation_p.R361Q	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	392	RabBD.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GAAGTGTCCCGAGCACGGCAT	0.478000										HNSCC(12;0.0054)			12	21					0	0	0.479597	0	0
LRRC37A2	474170	broad.mit.edu	37	17	44626216	44626216	+	Silent	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:44626216C>T	ENST00000576629.1	+	10	4206	c.3711C>T	c.(3709-3711)ttC>ttT	p.F1237F	ARL17A_ENST00000329240.4_Intron|ARL17A_ENST00000445552.2_Intron|LRRC37A2_ENST00000333412.3_Silent_p.F1237F|ARL17A_ENST00000573185.1_Intron|ARL17A_ENST00000337845.7_Intron			A6NM11	L37A2_HUMAN	leucine rich repeat containing 37, member A2	1237						integral to membrane				endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|pancreas(4)|prostate(2)	15		Melanoma(429;0.211)		BRCA - Breast invasive adenocarcinoma(366;0.232)		AGCCTTCCTTCACCCAAGAGC	0.592000													15	129					0	0	0.557998	0	0
C2CD3	26005	broad.mit.edu	37	11	73814325	73814325	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:73814325C>T	ENST00000334126.7	-	14	2657	c.2431G>A	c.(2431-2433)Gtg>Atg	p.V811M	C2CD3_ENST00000313663.7_Missense_Mutation_p.V811M			Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	811						centrosome				NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(26)|ovary(4)|pancreas(2)|prostate(1)|skin(3)	64	Breast(11;4.16e-06)					CCATCTGGCACCATCAACAGC	0.413000													23	105					0	0	0.654019	0	0
ITGB4	3691	broad.mit.edu	37	17	73738710	73738710	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:73738710G>A	ENST00000200181.3	+	25	3017	c.2830G>A	c.(2830-2832)Gta>Ata	p.V944I	ITGB4_ENST00000450894.3_Missense_Mutation_p.V944I|ITGB4_ENST00000579662.1_Missense_Mutation_p.V944I|ITGB4_ENST00000584558.1_3'UTR|ITGB4_ENST00000339591.3_Missense_Mutation_p.V944I|ITGB4_ENST00000449880.2_Missense_Mutation_p.V944I	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	944					cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCTGGTGGACGTACGGGTGCC	0.692000													4	120					0	0	0.217242	0	0
KIAA1522	57648	broad.mit.edu	37	1	33235330	33235330	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:33235330C>T	ENST00000401073.2	+	5	713	c.643C>T	c.(643-645)Cgg>Tgg	p.R215W	KIAA1522_ENST00000373480.1_Missense_Mutation_p.R156W|KIAA1522_ENST00000294521.3_Intron|KIAA1522_ENST00000373481.3_Missense_Mutation_p.R167W	NM_020888.2	NP_065939.2	Q9P206	K1522_HUMAN	KIAA1522	156										breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				AGGGCGGCGTCGGCGGGAGCG	0.627000													9	45					0	0	0.387290	0	0
EIF4G3	8672	broad.mit.edu	37	1	21329220	21329220	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:21329220G>A	ENST00000602326.1	-	5	599	c.16C>T	c.(16-18)Caa>Taa	p.Q6*	EIF4G3_ENST00000374937.3_Nonsense_Mutation_p.Q6*|EIF4G3_ENST00000400422.1_Nonsense_Mutation_p.Q6*|EIF4G3_ENST00000374935.3_Nonsense_Mutation_p.Q6*|EIF4G3_ENST00000264211.8_Nonsense_Mutation_p.Q6*|EIF4G3_ENST00000374927.4_Nonsense_Mutation_p.Q6*|EIF4G3_ENST00000356916.3_Nonsense_Mutation_p.Q6*	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	6					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		GAACGGGTTTGAGGTTGTGAA	0.443000													70	143					0	0	0.870114	0	0
CHAT	1103	broad.mit.edu	37	10	50873030	50873030	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr10:50873030G>A	ENST00000395562.2	+	16	2408	c.1939G>A	c.(1939-1941)Gag>Aag	p.E647K	CHAT_ENST00000339797.1_Missense_Mutation_p.E611K|CHAT_ENST00000351556.3_Missense_Mutation_p.E611K|CHAT_ENST00000395559.2_Missense_Mutation_p.E611K|CHAT_ENST00000337653.2_Missense_Mutation_p.E729K|CHAT_ENST00000455728.2_Intron	NM_001142933.1|NM_001142934.1	NP_001136405|NP_001136406.1	P28329	CLAT_HUMAN	choline O-acetyltransferase	729					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(11)|lung(34)|prostate(3)|urinary_tract(1)	56		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	GCCGCCTACTGAGAGCAAGCC	0.522000													54	60					0	0	0.870114	0	0
SIGLEC16	400709	broad.mit.edu	37	19	50473221	50473221	+	RNA	SNP	T	T	C	rs117072442	by1000genomes	TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr19:50473221T>C	ENST00000602139.1	+	0	222									sialic acid binding Ig-like lectin 16 (gene/pseudogene)									p.W65R(3)		endometrium(2)|kidney(2)|lung(6)	10						GTTCAAAGGATGGACCAGCCC	0.602000													3	38					0	0	0.115264	0	0
WAC	51322	broad.mit.edu	37	10	28897274	28897274	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr10:28897274C>T	ENST00000375664.4	+	8	1553	c.944C>T	c.(943-945)cCa>cTa	p.P315L	WAC_ENST00000354911.4_Missense_Mutation_p.P360L|WAC_ENST00000375646.1_Missense_Mutation_p.P212L|WAC_ENST00000428935.1_Missense_Mutation_p.P315L|WAC_ENST00000347934.4_Missense_Mutation_p.P257L			Q9BTA9	WAC_HUMAN	WW domain containing adaptor with coiled-coil						cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|urinary_tract(1)	32						CTTCAGGACCCAAATCTTCTT	0.448000													11	11					0	0	0.387290	0	0
CCDC150	284992	broad.mit.edu	37	2	197590756	197590756	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:197590756C>A	ENST00000389175.4	+	22	2624	c.2489C>A	c.(2488-2490)gCt>gAt	p.A830D	CCDC150_ENST00000487663.1_3'UTR|CCDC150_ENST00000272831.7_Missense_Mutation_p.A477D|CCDC150_ENST00000409270.1_Missense_Mutation_p.A317D	NM_001080539.1	NP_001074008.1	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	830										breast(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(14)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	33						CGCATAGAAGCTCTAAGAAAG	0.423000													7	16					1.06961e-07	1.11437e-07	0.278610	1	0
TENM3	55714	broad.mit.edu	37	4	183710449	183710449	+	Silent	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:183710449C>T	ENST00000511685.1	+	25	5631	c.5508C>T	c.(5506-5508)acC>acT	p.T1836T	TENM3_ENST00000406950.2_Silent_p.T1836T					teneurin transmembrane protein 3																		AGCGAGGCACCACTAGCGAGA	0.512000													7	43					0	0	0.335167	0	0
GATSL3	652968	broad.mit.edu	37	22	30682066	30682066	+	Silent	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr22:30682066C>T	ENST00000407689.3	-	7	894	c.765G>A	c.(763-765)ctG>ctA	p.L255L	GATSL3_ENST00000459785.1_Intron|RP1-130H16.18_ENST00000447976.1_3'UTR|GATSL3_ENST00000404953.3_Silent_p.L217L	NM_001037666.2	NP_001032755.1			GATS protein-like 3											breast(1)|endometrium(1)|lung(1)	3						AGGAGCTGGTCAGCAGGAGGT	0.672000													4	21					0	0	0.217242	0	0
PCSK9	255738	broad.mit.edu	37	1	55521852	55521852	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:55521852C>T	ENST00000302118.5	+	6	1276	c.986C>T	c.(985-987)tCa>tTa	p.S329L	PCSK9_ENST00000490692.1_3'UTR|PCSK9_ENST00000543384.1_Missense_Mutation_p.S129L	NM_174936.3	NP_777596.2	Q8NBP7	PCSK9_HUMAN	proprotein convertase subtilisin/kexin type 9	329	Peptidase S8.				cellular response to insulin stimulus|cellular response to starvation|cholesterol homeostasis|cholesterol metabolic process|kidney development|liver development|low-density lipoprotein particle receptor catabolic process|lysosomal transport|negative regulation of catalytic activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor recycling|neuron differentiation|positive regulation of neuron apoptosis|positive regulation of receptor internalization|protein autoprocessing|regulation of receptor activity	extracellular space|late endosome|lysosome|perinuclear region of cytoplasm	apolipoprotein receptor binding|identical protein binding|low-density lipoprotein particle receptor binding|serine-type endopeptidase activity|very-low-density lipoprotein particle receptor binding			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(1)|liver(2)|lung(4)|ovary(3)|prostate(3)|skin(1)|urinary_tract(1)	32						TCCCCAGCCTCAGCTCCCGAG	0.741000													8	9					0	0	0.361761	0	0
SYTL2	54843	broad.mit.edu	37	11	85445049	85445049	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:85445049G>C	ENST00000316356.4	-	7	1887	c.1323C>G	c.(1321-1323)atC>atG	p.I441M	SYTL2_ENST00000528231.1_Missense_Mutation_p.I440M|SYTL2_ENST00000389960.4_Missense_Mutation_p.I440M|SYTL2_ENST00000524452.1_Missense_Mutation_p.I440M|SYTL2_ENST00000527523.1_Missense_Mutation_p.I392M			Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2	440					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(22)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		TGGGTTCATTGATGGTTGGTG	0.383000													39	80					0	0	0.870114	0	0
NT5E	4907	broad.mit.edu	37	6	86194979	86194979	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr6:86194979G>A	ENST00000257770.3	+	4	827	c.778G>A	c.(778-780)Gct>Act	p.A260T	NT5E_ENST00000369651.3_Missense_Mutation_p.A260T	NM_002526.3	NP_002517.1	P21589	5NTD_HUMAN	5'-nucleotidase, ecto (CD73)	260					DNA metabolic process|purine base metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	5'-nucleotidase activity|nucleotide binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(76;0.000215)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0427)		BRCA - Breast invasive adenocarcinoma(108;0.0417)	Pentoxifylline(DB00806)	AGAGGTGCCTGCTGGGAAGTA	0.502000													9	55					0	0	0.335167	0	0
DLX4	1748	broad.mit.edu	37	17	48047109	48047109	+	Missense_Mutation	SNP	G	G	A	rs145736583		TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:48047109G>A	ENST00000240306.3	+	1	572	c.277G>A	c.(277-279)Gag>Aag	p.E93K	DLX4_ENST00000505318.2_Missense_Mutation_p.E93K|DLX4_ENST00000503410.1_3'UTR	NM_138281.2	NP_612138.1	Q92988	DLX4_HUMAN	distal-less homeobox 4	93				MTSLPCPLPGRDASKAVFPDLAPVPSVAAAYPLGLSPTTAA SPNLSYSRPYGHLLSYPYTEPANPGDSYLSCQQPAALSQPL CGPAEHPQELEA -> GGSLSLPPEPLCARCPTKEGAAPRR PGFWGSLETQAATVWRGRHGHFSCRVRLSRGAARYSRRGQG KPGVTISAARLVFKVLSAGPLTHPAGRSRRLPRGHRLKPLS IALSLCLQCPSSVISRPRLSPGPSLSAPPYPKLAPPPVAEL RPPTAGAAVPWLWPSARFLPRVTGPIRVGAPLGAELRLVSP GAVNVGVETLHAE (in Ref. 9).	multicellular organismal development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(3)	10						TCAGGAACTCGAGGCAGGTAA	0.667000													14	108					0	0	0.457914	0	0
PPP2R3A	5523	broad.mit.edu	37	3	135720804	135720804	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:135720804C>T	ENST00000264977.3	+	2	1081	c.464C>T	c.(463-465)tCa>tTa	p.S155L	PPP2R3A_ENST00000490467.1_Intron	NM_001190447.1|NM_002718.4	NP_001177376.1|NP_002709.2	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'', alpha	155					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			breast(2)|cervix(1)|endometrium(2)|large_intestine(7)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						AATAGGAGGTCAGTTGATTTG	0.398000													6	34					0	0	0.248553	0	0
NIPSNAP1	8508	broad.mit.edu	37	22	29957498	29957498	+	Silent	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr22:29957498G>C	ENST00000216121.7	-	6	830	c.576C>G	c.(574-576)ctC>ctG	p.L192L		NM_001202502.1|NM_003634.3	NP_001189431.1|NP_003625.2	Q9BPW8	NIPS1_HUMAN	nipsnap homolog 1 (C. elegans)	192								p.?(1)		large_intestine(2)|lung(2)|skin(1)	5						GAGGCACCTTGAGCTTGTATG	0.577000													44	83					0	0	0.870114	0	0
KRT80	144501	broad.mit.edu	37	12	52574708	52574708	+	Silent	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr12:52574708G>A	ENST00000313234.5	-	3	646	c.549C>T	c.(547-549)ttC>ttT	p.F183F	KRT80_ENST00000394815.2_Silent_p.F183F	NM_001081492.1	NP_001074961.1	Q6KB66	K2C80_HUMAN	keratin 80	183	Coil 1B.|Rod.					keratin filament	structural molecule activity			endometrium(2)|large_intestine(2)|lung(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.108)		GAACAAAGGTGAACTCCATGT	0.592000													24	43					0	0	0.729181	0	0
MUC16	94025	broad.mit.edu	37	19	9077046	9077046	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr19:9077046C>G	ENST00000397910.4	-	3	10603	c.10400G>C	c.(10399-10401)gGa>gCa	p.G3467A		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3468	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCCTTGGTCTCCAGAGGGCAG	0.507000													5	24					0	0	0.248553	0	0
HS3ST4	9951	broad.mit.edu	37	16	26147147	26147147	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr16:26147147A>C	ENST00000331351.5	+	2	1341	c.949A>C	c.(949-951)Aaa>Caa	p.K317Q	HS3ST4_ENST00000475436.1_3'UTR	NM_006040.2	NP_006031.2	Q9Y661	HS3S4_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 4	317					heparan sulfate proteoglycan metabolic process	extracellular region|Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			breast(2)|endometrium(3)|large_intestine(1)|lung(9)	15				GBM - Glioblastoma multiforme(48;0.0988)		GCTGGCCTTCAAAAACCGGAC	0.547000													72	170					0	0	0.870114	0	0
NUP85	79902	broad.mit.edu	37	17	73231253	73231253	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:73231253C>G	ENST00000245544.4	+	18	1897	c.1826C>G	c.(1825-1827)tCa>tGa	p.S609*	NUP85_ENST00000579324.1_Nonsense_Mutation_p.S497*|NUP85_ENST00000541827.1_Nonsense_Mutation_p.S563*|NUP85_ENST00000540768.1_Nonsense_Mutation_p.S212*|NUP85_ENST00000447371.2_3'UTR|NUP85_ENST00000579298.1_Nonsense_Mutation_p.S564*	NM_024844.3	NP_079120.1	Q9BW27	NUP85_HUMAN	nucleoporin 85kDa	609					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|nuclear membrane|Nup107-160 complex|spindle	protein binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	16	all_lung(278;0.14)|Lung NSC(278;0.168)		all cancers(21;3.45e-06)			GACTTGACGTCAAGAAGACCT	0.522000													8	75					0	0	0.457914	0	0
FAT4	79633	broad.mit.edu	37	4	126238826	126238826	+	Silent	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126238826C>T	ENST00000394329.3	+	1	1273	c.1260C>T	c.(1258-1260)atC>atT	p.I420I		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	420	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TGAGCCTAATCAAGGTGGCCA	0.607000											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	29					0	0	0.457914	0	0
FNDC1	84624	broad.mit.edu	37	6	159653433	159653433	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr6:159653433C>G	ENST00000297267.9	+	11	2089	c.1889C>G	c.(1888-1890)tCt>tGt	p.S630C	FNDC1_ENST00000340366.6_Missense_Mutation_p.S567C	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	630						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		CAGGGCACCTCTCATCGTCCT	0.667000													12	96					0	0	0.539581	0	0
PRG4	10216	broad.mit.edu	37	1	186276100	186276100	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:186276100A>C	ENST00000445192.2	+	7	1294	c.1249A>C	c.(1249-1251)Acc>Ccc	p.T417P	PRG4_ENST00000367486.3_Missense_Mutation_p.T374P|PRG4_ENST00000367483.4_Missense_Mutation_p.T376P|PRG4_ENST00000367484.3_Intron|PRG4_ENST00000367485.4_Missense_Mutation_p.T324P	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	417	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity	p.T417P(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						ACCCACCACCACCAAGGAGCC	0.652000													5	105					0	0	0.335167	0	0
FAT4	79633	broad.mit.edu	37	4	126239094	126239094	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126239094C>G	ENST00000394329.3	+	1	1541	c.1528C>G	c.(1528-1530)Ctg>Gtg	p.L510V		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	510	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CAATGCTAATCTGCGTTACAG	0.557000											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	53					0	0	0.639603	0	0
C2orf44	80304	broad.mit.edu	37	2	24260579	24260579	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:24260579G>C	ENST00000295148.4	-	2	1843	c.1786C>G	c.(1786-1788)Caa>Gaa	p.Q596E	C2orf44_ENST00000406895.3_Missense_Mutation_p.Q596E	NM_025203.2	NP_079479.1	Q9H6R7	CB044_HUMAN	chromosome 2 open reading frame 44	596							protein binding	p.Q596E(1)	C2orf44/ALK(2)	breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGAAGATCTTGAGAGAGTGGA	0.403000			T	ALK	NSCLC								34	91					0	0	0.853193	0	0
INTS4	92105	broad.mit.edu	37	11	77669853	77669853	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:77669853C>T	ENST00000534064.1	-	7	770	c.736G>A	c.(736-738)Gaa>Aaa	p.E246K	INTS4_ENST00000529807.1_Missense_Mutation_p.E246K	NM_033547.3	NP_291025.3	Q96HW7	INT4_HUMAN	integrator complex subunit 4	246					snRNA processing	integrator complex	protein binding		INTS4/GAB2(2)	NS(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(5)|upper_aerodigestive_tract(1)	32	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			CGCACTTGTTCATAGTCATCA	0.428000													6	31					0	0	0.248553	0	0
SPTBN1	6711	broad.mit.edu	37	2	54855387	54855387	+	Splice_Site	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:54855387G>A	ENST00000333896.5	+	12	2144	c.1759G>A	c.(1759-1761)Ggt>Agt	p.G587S	SPTBN1_ENST00000356805.4_Splice_Site_p.G600S	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	600					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			AGACGGGGAAGGTAAGGATGG	0.507000													3	47					0	0	0.150653	0	0
ZNF646	9726	broad.mit.edu	37	16	31090265	31090265	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr16:31090265G>A	ENST00000394979.2	+	1	3043	c.2620G>A	c.(2620-2622)Gag>Aag	p.E874K	ZNF646_ENST00000300850.5_Missense_Mutation_p.E874K			O15015	ZN646_HUMAN	zinc finger protein 646	874					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(1)|lung(21)|ovary(1)|prostate(4)|skin(3)	49						TAGGCCTGGGGAGGCGACCTC	0.647000													33	87					0	0	0.779181	0	0
FRG1B	284802	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	G	A	rs7266938	by1000genomes	TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr20:29625877G>A	ENST00000278882.3	+	5	501	c.121G>A	c.(121-123)Gcc>Acc	p.A41T	FRG1B_ENST00000358464.4_Missense_Mutation_p.A41T|FRG1B_ENST00000439954.2_Missense_Mutation_p.A46T														p.A41T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTACAGAATCGCCCTGAAATC	0.358000													5	39					0	0	0.184627	0	0
C9orf43	257169	broad.mit.edu	37	9	116190476	116190476	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr9:116190476G>C	ENST00000288462.4	+	12	1526	c.1080G>C	c.(1078-1080)caG>caC	p.Q360H	C9orf43_ENST00000374165.1_Missense_Mutation_p.Q360H	NM_152786.1	NP_689999.1	Q8TAL5	CI043_HUMAN	chromosome 9 open reading frame 43	360										breast(2)|large_intestine(6)|lung(2)|ovary(1)|pancreas(1)|prostate(3)	15						AGCAGCAGCAGATGGAAAAAG	0.438000													3	127					0	0	0.115264	0	0
FAT4	79633	broad.mit.edu	37	4	126239494	126239494	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126239494C>G	ENST00000394329.3	+	1	1941	c.1928C>G	c.(1927-1929)aCt>aGt	p.T643S		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	643	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AGGTTGAGTACTATTTCCTCC	0.552000													17	29					0	0	0.539581	0	0
OR3A2	4995	broad.mit.edu	37	17	3181440	3181440	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:3181440C>A	ENST00000408891.2	-	1	828	c.790G>T	c.(790-792)Ggt>Tgt	p.G264C		NM_002551.3	NP_002542.3	P47893	OR3A2_HUMAN	olfactory receptor, family 3, subfamily A, member 2	264					sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						TTGAAGATACCTCTTCCAAAG	0.502000													3	27					0.150653	0.152491	0.150653	1	0
COL6A6	131873	broad.mit.edu	37	3	130282320	130282320	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:130282320G>A	ENST00000358511.6	+	2	504	c.473G>A	c.(472-474)gGa>gAa	p.G158E	COL6A6_ENST00000453409.2_Missense_Mutation_p.G158E	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	158	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						CGGAAAGACGGAGTGAAAATC	0.498000													4	30					0	0	0.150653	0	0
MFF	56947	broad.mit.edu	37	2	228194464	228194464	+	Translation_Start_Site	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:228194464G>A	ENST00000353339.3	+	3	444	c.3G>A	c.(1-3)atG>atA	p.M1I	MFF_ENST00000409616.1_5'UTR|MFF_ENST00000392059.1_Start_Codon_SNP_p.M1I|MFF_ENST00000337110.7_Intron|MFF_ENST00000304593.9_Intron|MFF_ENST00000476924.1_Intron|MFF_ENST00000349901.7_Intron|MFF_ENST00000524634.1_Intron|MFF_ENST00000409565.1_Intron|MFF_ENST00000354503.6_Intron	NM_001277061.1	NP_001263990.1	Q9GZY8	MFF_HUMAN	mitochondrial fission factor	1						integral to membrane|mitochondrial outer membrane				breast(3)|endometrium(2)|kidney(3)|large_intestine(7)|lung(4)|stomach(2)	21						GTATTTAAATGAGTAAAGGAA	0.343000													17	53					0	0	0.608945	0	0
LENG8	114823	broad.mit.edu	37	19	54972001	54972001	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr19:54972001G>A	ENST00000326764.5	+	16	2775	c.2296G>A	c.(2296-2298)Gag>Aag	p.E766K	LENG8_ENST00000376514.2_Intron	NM_052925.2	NP_443157.1	Q96PV6	LENG8_HUMAN	leukocyte receptor cluster (LRC) member 8	0							protein binding			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		CTTCGAGGGCGAGGCCGCCTG	0.701000													4	14					0	0	0.150653	0	0
FAT4	79633	broad.mit.edu	37	4	126240492	126240492	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126240492C>T	ENST00000394329.3	+	1	2939	c.2926C>T	c.(2926-2928)Ctc>Ttc	p.L976F		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	976	Cadherin 9.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TGTCCCACAGCTCTCCTCTAG	0.443000													20	53					0	0	0.624587	0	0
DCST2	127579	broad.mit.edu	37	1	154995858	154995858	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:154995858C>A	ENST00000368424.3	-	13	2004	c.1946G>T	c.(1945-1947)gGg>gTg	p.G649V		NM_144622.2	NP_653223.2	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	649						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|prostate(1)|skin(1)	38	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GTCCAGGTCCCCCTGGTAGGA	0.602000													11	21					2.62699e-14	2.79538e-14	0.479597	1	0
NF1	4763	broad.mit.edu	37	17	29701127	29701127	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:29701127G>C	ENST00000358273.4	+	58	8857	c.8474G>C	c.(8473-8475)aGa>aCa	p.R2825T	NF1_ENST00000356175.3_Missense_Mutation_p.R2804T|NF1_ENST00000444181.2_Missense_Mutation_p.R618T	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	2825					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(3)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CAGAAGCAAAGAAGCGCTGGC	0.468000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			9	49					0	0	0.387290	0	0
HSPA4L	22824	broad.mit.edu	37	4	128722997	128722997	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:128722997G>C	ENST00000296464.4	+	6	998	c.587G>C	c.(586-588)aGa>aCa	p.R196T	HSPA4L_ENST00000505726.1_Missense_Mutation_p.R170T|HSPA4L_ENST00000439123.2_Missense_Mutation_p.R227T|HSPA4L_ENST00000508776.1_Missense_Mutation_p.R196T	NM_014278.2	NP_055093.2	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like						protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	31						GAGAAACCAAGAAATGTAGTA	0.328000													15	13					0	0	0.539581	0	0
CD163	9332	broad.mit.edu	37	12	7640120	7640120	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr12:7640120C>A	ENST00000359156.4	-	8	2087	c.1885G>T	c.(1885-1887)Gcc>Tcc	p.A629S	CD163_ENST00000396620.3_Missense_Mutation_p.A662S|CD163_ENST00000432237.2_Missense_Mutation_p.A629S|CD163_ENST00000541972.1_Missense_Mutation_p.A617S	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	629	SRCR 6.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						GTAGAAAGGGCAACTCCACAT	0.507000													28	116					2.61193e-14	2.79129e-14	0.740014	1	0
DHX29	54505	broad.mit.edu	37	5	54593198	54593198	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr5:54593198C>A	ENST00000251636.5	-	3	438	c.290G>T	c.(289-291)aGa>aTa	p.R97I		NM_019030.2	NP_061903.2	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	97							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|lung(6)|ovary(4)|prostate(1)|skin(3)|urinary_tract(2)	46		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				TCCAATAATTCTTTGCTCTAG	0.299000													3	13					0.115264	0.117626	0.115264	1	0
TPRG1	285386	broad.mit.edu	37	3	188933083	188933083	+	Silent	SNP	G	G	A	rs141310543		TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:188933083G>A	ENST00000345063.3	+	3	380	c.213G>A	c.(211-213)ccG>ccA	p.P71P	TPRG1_ENST00000433971.1_Silent_p.P71P	NM_198485.3	NP_940887.1	Q6ZUI0	TPRG1_HUMAN	tumor protein p63 regulated 1	71										endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|skin(2)|urinary_tract(1)	16	all_cancers(143;6.12e-12)|all_hematologic(3;0.0359)|Ovarian(172;0.0925)	all_lung(153;8.23e-09)|Lung NSC(153;3.55e-06)|all_neural(597;0.0019)|Myeloproliferative disorder(1037;0.0255)	Lung(62;6.93e-06)	GBM - Glioblastoma multiforme(93;4.77e-14)		CCACACAGCCGGGGGCCATTG	0.488000													25	23					0	0	0.788014	0	0
IFRD1	3475	broad.mit.edu	37	7	112096991	112096991	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr7:112096991C>A	ENST00000403825.3	+	4	568	c.307C>A	c.(307-309)Ctt>Att	p.L103I	IFRD1_ENST00000005558.4_Missense_Mutation_p.L103I|IFRD1_ENST00000535603.1_Missense_Mutation_p.L53I|IFRD1_ENST00000429071.1_Missense_Mutation_p.L103I	NM_001550.3	NP_001541.2	O00458	IFRD1_HUMAN	interferon-related developmental regulator 1	103					multicellular organismal development|myoblast cell fate determination		binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(5)|urinary_tract(1)	15						GCAAGCAGCTCTTGAAGGTAT	0.338000													3	39					0.00024832	0.000257632	0.150653	1	0
OR9K2	441639	broad.mit.edu	37	12	55523876	55523876	+	Silent	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr12:55523876C>T	ENST00000305377.5	+	1	412	c.324C>T	c.(322-324)atC>atT	p.I108I		NM_001005243.1	NP_001005243.1	Q8NGE7	OR9K2_HUMAN	olfactory receptor, family 9, subfamily K, member 2	108					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(3)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(2)	31						AGGCTATGATCAACTTCTGGT	0.453000													16	64					0	0	0.500413	0	0
IKBKB	3551	broad.mit.edu	37	8	42183487	42183487	+	Splice_Site	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr8:42183487G>C	ENST00000520810.1	+	20	2172		c.e20-1		IKBKB_ENST00000379708.3_Splice_Site|IKBKB_ENST00000520835.1_Splice_Site|IKBKB_ENST00000522147.1_Intron|IKBKB_ENST00000416505.2_Splice_Site	NM_001556.2	NP_001547.1	O14920	IKKB_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta						anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(4)|lung(1)|ovary(2)|skin(1)	8	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	TTGTCCCCTAGAGCAAGGTCC	0.522000													44	157					0	0	0.870114	0	0
HDDC2	51020	broad.mit.edu	37	6	125621706	125621706	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr6:125621706C>T	ENST00000368377.4	-	2	387	c.184G>A	c.(184-186)Gat>Aat	p.D62N	HDDC2_ENST00000608284.1_Missense_Mutation_p.D62N|HDDC2_ENST00000608295.1_Missense_Mutation_p.D62N|HDDC2_ENST00000398153.2_Missense_Mutation_p.D62N			Q7Z4H3	HDDC2_HUMAN	HD domain containing 2	62	HD.						metal ion binding|phosphoric diester hydrolase activity			endometrium(1)|large_intestine(1)|lung(4)	6			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0186)		AGACGGTCATCTTTGATCACC	0.498000													15	61					0	0	0.500413	0	0
ASH1L	55870	broad.mit.edu	37	1	155449222	155449222	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:155449222G>A	ENST00000368346.3	-	3	4078	c.3439C>T	c.(3439-3441)Cag>Tag	p.Q1147*	ASH1L_ENST00000392403.3_Nonsense_Mutation_p.Q1147*			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	1147					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			GCAAGAGTCTGAATCATACTG	0.473000													16	46					0	0	0.520397	0	0
SLFN5	162394	broad.mit.edu	37	17	33586688	33586688	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:33586688G>C	ENST00000299977.4	+	2	1127	c.979G>C	c.(979-981)Gaa>Caa	p.E327Q	SLFN5_ENST00000542451.1_Missense_Mutation_p.E327Q|SLFN5_ENST00000592325.1_Missense_Mutation_p.E327Q	NM_144975.3	NP_659412.3	Q08AF3	SLFN5_HUMAN	schlafen family member 5	327					cell differentiation		ATP binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(8)|liver(2)|lung(6)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	34		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		GCCCACAAGAGAATGGACTGC	0.517000													29	107					0	0	0.740014	0	0
MUC6	4588	broad.mit.edu	37	11	1017507	1017507	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:1017507G>A	ENST00000421673.2	-	31	5344	c.5294C>T	c.(5293-5295)tCt>tTt	p.S1765F		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	1765	Approximate repeats.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCTGGTGGTAGAAGTTGAGGT	0.577000													33	1082					0	0	0.654019	0	0
TP53	7157	broad.mit.edu	37	17	7578275	7578275	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:7578275G>A	ENST00000420246.2	-	6	706	c.574C>T	c.(574-576)Cag>Tag	p.Q192*	TP53_ENST00000445888.2_Nonsense_Mutation_p.Q192*|TP53_ENST00000359597.4_Nonsense_Mutation_p.Q192*|TP53_ENST00000574684.1_Intron|TP53_ENST00000413465.2_Nonsense_Mutation_p.Q192*|TP53_ENST00000455263.2_Nonsense_Mutation_p.Q192*|TP53_ENST00000269305.4_Nonsense_Mutation_p.Q192*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	192	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		Q -> H (in sporadic cancers; somatic mutation).|Q -> K (in a sporadic cancer; somatic mutation).|Q -> L (in sporadic cancers; somatic mutation).|Q -> P (in sporadic cancers; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q192*(83)|p.0?(8)|p.Q99*(6)|p.?(6)|p.Q60*(6)|p.P191del(4)|p.P191delP(4)|p.A189_V197delAPPQHLIRV(4)|p.P191_E198>Q(3)|p.P191fs*53(2)|p.G187fs*16(2)|p.P59delP(2)|p.P98delP(2)|p.P191fs*6(1)|p.A189_Q192>E(1)|p.P59_E66>Q(1)|p.P191fs*15(1)|p.P191_Q192delPQ(1)|p.Q192K(1)|p.P98_E105>Q(1)|p.A189fs*53(1)|p.Q192del(1)|p.Q192fs*16(1)|p.L188_P191del(1)|p.Q192fs*30(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATAAGATGCTGAGGAGGGGCC	0.557000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	32					0	0	0.539581	0	0
SRRM2	23524	broad.mit.edu	37	16	2813668	2813668	+	Missense_Mutation	SNP	G	G	A	rs150618420	by1000genomes	TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr16:2813668G>A	ENST00000301740.8	+	11	3688	c.3139G>A	c.(3139-3141)Gag>Aag	p.E1047K		NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	1047	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						ACCACCAGGCGAGAGCTATTT	0.468000													12	83					0	0	0.479597	0	0
KDM4B	23030	broad.mit.edu	37	19	5135468	5135468	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr19:5135468C>G	ENST00000159111.4	+	15	2422	c.2204C>G	c.(2203-2205)tCt>tGt	p.S735C	KDM4B_ENST00000536461.1_Missense_Mutation_p.S769C	NM_015015.2	NP_055830	O94953	KDM4B_HUMAN	lysine (K)-specific demethylase 4B	735					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(1)|liver(1)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						TGCTTCACCTCTGGCGGTGAG	0.642000													13	37					0	0	0.435327	0	0
PLEKHF2	79666	broad.mit.edu	37	8	96166849	96166849	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr8:96166849C>T	ENST00000315367.3	+	2	818	c.577C>T	c.(577-579)Ctt>Ttt	p.L193F	PLEKHF2_ENST00000519516.1_Missense_Mutation_p.L193F	NM_024613.3	NP_078889.1	Q9H8W4	PKHF2_HUMAN	pleckstrin homology domain containing, family F (with FYVE domain) member 2	193						transport vesicle	metal ion binding|protein binding			breast(1)|large_intestine(1)|lung(1)|ovary(2)	5	Breast(36;3.18e-05)					GAGATTTCTTCTTCCCAGCCA	0.507000													51	98					0	0	0.870114	0	0
ATP2B2	491	broad.mit.edu	37	3	10401790	10401790	+	Silent	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:10401790G>C	ENST00000397077.1	-	12	2117	c.1542C>G	c.(1540-1542)ggC>ggG	p.G514G	ATP2B2_ENST00000360273.2_Silent_p.G559G|ATP2B2_ENST00000352432.4_Silent_p.G559G|ATP2B2_ENST00000383800.4_Silent_p.G514G|ATP2B2_ENST00000343816.4_Silent_p.G545G			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	559					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						GAGGCAGGGCGCCCTCCTTCT	0.687000													30	53					0	0	0.840704	0	0
PLXNB2	23654	broad.mit.edu	37	22	50714172	50714172	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr22:50714172C>G	ENST00000449103.1	-	37	5618	c.5478G>C	c.(5476-5478)caG>caC	p.Q1826H	PLXNB2_ENST00000359337.4_Missense_Mutation_p.Q1826H|AL022328.1_ENST00000595015.1_Missense_Mutation_p.L24V			O15031	PLXB2_HUMAN	plexin B2	1826					regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CAGCGGCAATCTGCTGCAGGC	0.597000											OREG0026679	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	55					0	0	0.411799	0	0
GPR45	11250	broad.mit.edu	37	2	105858447	105858447	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:105858447G>A	ENST00000258456.1	+	1	248	c.132G>A	c.(130-132)atG>atA	p.M44I		NM_007227.3	NP_009158.3	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	44						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	28						TGCTGCTGATGACCGTGGTGG	0.617000													74	193					0	0	0.870114	0	0
EPHB4	2050	broad.mit.edu	37	7	100417263	100417263	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr7:100417263C>G	ENST00000358173.3	-	6	1681	c.1213G>C	c.(1213-1215)Gag>Cag	p.E405Q	EPHB4_ENST00000360620.3_Missense_Mutation_p.E405Q|EPHB4_ENST00000477446.1_5'UTR	NM_004444.4	NP_004435.3	P54760	EPHB4_HUMAN	EPH receptor B4	405	Fibronectin type-III 1.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(3)	47	Lung NSC(181;0.041)|all_lung(186;0.0581)					GCAGTGACCTCAAAGGTATAG	0.622000													13	146					0	0	0.479597	0	0
THAP4	51078	broad.mit.edu	37	2	242572898	242572898	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:242572898C>T	ENST00000407315.1	-	2	1105	c.674G>A	c.(673-675)gGa>gAa	p.G225E		NM_015963.5	NP_057047.4	Q8WY91	THAP4_HUMAN	THAP domain containing 4	225							DNA binding|metal ion binding			kidney(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)	9		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;2.3e-33)|all cancers(36;8.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.68e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0844)		CGCCCCAGATCCTGGGGGCGT	0.557000													28	63					0	0	0.729181	0	0
KIAA1522	57648	broad.mit.edu	37	1	33236198	33236198	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:33236198C>G	ENST00000401073.2	+	6	1488	c.1418C>G	c.(1417-1419)tCa>tGa	p.S473*	KIAA1522_ENST00000373480.1_Nonsense_Mutation_p.S414*|KIAA1522_ENST00000294521.3_Intron|KIAA1522_ENST00000373481.3_Nonsense_Mutation_p.S425*	NM_020888.2	NP_065939.2	Q9P206	K1522_HUMAN	KIAA1522	414	Pro-rich.									breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				GCTGAGGCCTCAGACACACTC	0.677000													7	67					0	0	0.335167	0	0
FAT4	79633	broad.mit.edu	37	4	126239141	126239141	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126239141C>G	ENST00000394329.3	+	1	1588	c.1575C>G	c.(1573-1575)atC>atG	p.I525M		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	525	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GGTTCCATATCAGTGAACATA	0.537000											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	71					0	0	0.779181	0	0
CACNA1F	778	broad.mit.edu	37	X	49071570	49071570	+	Silent	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chrX:49071570G>C	ENST00000376265.2	-	29	3667	c.3606C>G	c.(3604-3606)ctC>ctG	p.L1202L	CACNA1F_ENST00000323022.5_Silent_p.L1191L|CACNA1F_ENST00000376251.1_Silent_p.L1137L	NM_005183.2	NP_005174.2	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type, alpha 1F subunit	1202					axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(8)|central_nervous_system(3)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(4)|urinary_tract(1)	85					Verapamil(DB00661)	CAACTGTGTTGAGCAGGATGA	0.552000													29	29					0	0	0.827153	0	0
CFHR1	3078	broad.mit.edu	37	1	196794771	196794771	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:196794771G>C	ENST00000320493.5	+	2	311	c.223G>C	c.(223-225)Gaa>Caa	p.E75Q	CFHR2_ENST00000367421.3_Intron|CFHR1_ENST00000367424.4_Missense_Mutation_p.E75Q	NM_002113.2	NP_002104.2	Q03591	FHR1_HUMAN	complement factor H-related 1	75	Sushi 1.				complement activation	extracellular space				NS(1)|kidney(1)|large_intestine(2)|lung(7)	11						ATGCACAGAAGAAGGATGGTC	0.388000													21	46					0	0	0.729181	0	0
FBN1	2200	broad.mit.edu	37	15	48779383	48779383	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr15:48779383C>T	ENST00000316623.5	-	29	3933	c.3478G>A	c.(3478-3480)Gag>Aag	p.E1160K		NM_000138.4	NP_000129	P35555	FBN1_HUMAN	fibrillin 1	1160	EGF-like 18; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		GCACTCAGCTCACATTCATTG	0.468000													7	63					0	0	0.361761	0	0
FLNC	2318	broad.mit.edu	37	7	128488646	128488646	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr7:128488646G>C	ENST00000325888.8	+	27	4873	c.4612G>C	c.(4612-4614)Gat>Cat	p.D1538H	FLNC_ENST00000346177.6_Missense_Mutation_p.D1538H	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1538					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CCCAGCTCATGATGCCAGCAA	0.642000													54	254					0	0	0.870114	0	0
DOCK9	23348	broad.mit.edu	37	13	99459962	99459962	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr13:99459962C>G	ENST00000376460.1	-	51	5589	c.5509G>C	c.(5509-5511)Gat>Cat	p.D1837H	DOCK9_ENST00000339416.2_Missense_Mutation_p.D1824H	NM_001130048.1|NM_015296.2	NP_001123520.1|NP_056111.1	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	1838	DHR-2.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CCAAATTTATCCGAGTACAGT	0.373000													9	39					0	0	0.361761	0	0
CENPE	1062	broad.mit.edu	37	4	104082321	104082321	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:104082321C>T	ENST00000265148.3	-	20	2142	c.2053G>A	c.(2053-2055)Gat>Aat	p.D685N	CENPE_ENST00000380026.3_Missense_Mutation_p.D660N	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	685					blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TTCTCCAGATCAACTTGCATT	0.313000													6	16					0	0	0.248553	0	0
FAT4	79633	broad.mit.edu	37	4	126240344	126240344	+	Silent	SNP	C	C	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126240344C>A	ENST00000394329.3	+	1	2791	c.2778C>A	c.(2776-2778)ggC>ggA	p.G926G		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	926	Cadherin 9.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GTGTCAATGGCATGGTACTCT	0.473000													8	40					0.000978159	0.00101063	0.387290	1	0
CHD4	1108	broad.mit.edu	37	12	6705273	6705273	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr12:6705273C>G	ENST00000309577.6	-	13	2086	c.1923G>C	c.(1921-1923)ttG>ttC	p.L641F	CHD4_ENST00000357008.2_Missense_Mutation_p.L641F|CHD4_ENST00000544040.1_Missense_Mutation_p.L634F|CHD4_ENST00000544484.1_Missense_Mutation_p.L638F			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	641	Chromo 2.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						GCCACTTGATCAAGTAGTGGA	0.507000													31	75					0	0	0.769981	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64599095	64599095	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:64599095C>T	ENST00000498707.1	-	22	3622	c.3280G>A	c.(3280-3282)Gag>Aag	p.E1094K	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.E1066K	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	1094	TSP type-1 5.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GGCTTGGTCTCAGGGTCACAC	0.488000													17	102					0	0	0.592651	0	0
MYO1G	64005	broad.mit.edu	37	7	45015119	45015119	+	Silent	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr7:45015119C>T	ENST00000258787.7	-	4	664	c.528G>A	c.(526-528)ccG>ccA	p.P176P		NM_033054.2	NP_149043.2	B0I1T2	MYO1G_HUMAN	myosin IG	176	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|skin(4)	28						GTCCTCCGATCGGGTCCCCCT	0.607000													16	28					0	0	0.654019	0	0
CENPE	1062	broad.mit.edu	37	4	104082409	104082409	+	Splice_Site	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:104082409C>T	ENST00000265148.3	-	20	2055		c.e20-1		CENPE_ENST00000380026.3_Splice_Site	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa						blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		CAAGTTCTTTCTATTGAGAAA	0.303000													3	13					0	0	0.150653	0	0
PLEKHA8	84725	broad.mit.edu	37	7	30094402	30094402	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr7:30094402G>A	ENST00000449726.1	+	8	1224	c.874G>A	c.(874-876)Gac>Aac	p.D292N	PLEKHA8_ENST00000396259.1_Missense_Mutation_p.D292N|PLEKHA8_ENST00000258679.7_Missense_Mutation_p.D292N|PLEKHA8_ENST00000396257.2_Missense_Mutation_p.D292N	NM_001197027.1	NP_001183956.1	Q96JA3	PKHA8_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8	292					protein transport	cytoplasm	glycolipid binding|glycolipid transporter activity			breast(4)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)	17						GTCTGGATCAGACTCAAGTTG	0.383000													22	79					0	0	0.667858	0	0
LRRCC1	85444	broad.mit.edu	37	8	86050700	86050700	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr8:86050700G>C	ENST00000414626.2	+	16	3659	c.2770G>C	c.(2770-2772)Gaa>Caa	p.E924Q	LRRCC1_ENST00000360375.3_Missense_Mutation_p.E944Q			Q9C099	LRCC1_HUMAN	leucine rich repeat and coiled-coil centrosomal protein 1	944					cell division|mitosis	centriole|nucleus				breast(3)|central_nervous_system(1)|endometrium(4)|kidney(9)|large_intestine(7)|lung(16)|skin(1)|upper_aerodigestive_tract(2)	43						CAAAAGTATTGAACTACAAAA	0.333000													13	20					0	0	0.500413	0	0
RBBP6	5930	broad.mit.edu	37	16	24583041	24583041	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr16:24583041A>G	ENST00000319715.4	+	18	5086	c.4654A>G	c.(4654-4656)Aaa>Gaa	p.K1552E	RBBP6_ENST00000348022.2_Missense_Mutation_p.K1518E|RBBP6_ENST00000381039.3_Missense_Mutation_p.K712E	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	1552					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		TTATGATACTAAACGGCCAAA	0.368000													13	33					0	0	0.479597	0	0
FAT4	79633	broad.mit.edu	37	4	126240563	126240563	+	Silent	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126240563C>G	ENST00000394329.3	+	1	3010	c.2997C>G	c.(2995-2997)ctC>ctG	p.L999L		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	999	Cadherin 10.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TTGACCAACTCTCTTATGAAG	0.408000													34	85					0	0	0.853193	0	0
PCDHB10	56126	broad.mit.edu	37	5	140572567	140572567	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr5:140572567G>A	ENST00000239446.4	+	1	626	c.442G>A	c.(442-444)Gaa>Aaa	p.E148K		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		148	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAATACAGCTGAAGGGACAGC	0.413000													27	42					0	0	0.706142	0	0
FMNL2	114793	broad.mit.edu	37	2	153483060	153483060	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:153483060G>C	ENST00000288670.9	+	17	2351	c.1984G>C	c.(1984-1986)Gag>Cag	p.E662Q	FMNL2_ENST00000475377.2_Missense_Mutation_p.E37Q|FMNL2_ENST00000497192.1_3'UTR	NM_052905.3	NP_443137.2	Q96PY5	FMNL2_HUMAN	formin-like 2	662	FH2.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(2)|lung(3)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	23						GGATGAATTTGAGGAAATATT	0.358000													5	9					0	0	0.184627	0	0
MMP25	64386	broad.mit.edu	37	16	3100442	3100442	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr16:3100442G>A	ENST00000336577.4	+	4	793	c.556G>A	c.(556-558)Gac>Aac	p.D186N	MMP25_ENST00000570755.1_3'UTR	NM_022468.4	NP_071913.1	Q9NPA2	MMP25_HUMAN	matrix metallopeptidase 25	186					inflammatory response|proteolysis	anchored to membrane|cell surface|plasma membrane|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	14						CTACCCCTTCGACGGGTTGGG	0.622000													34	62					0	0	0.834066	0	0
N4BP2	55728	broad.mit.edu	37	4	40146258	40146258	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:40146258C>G	ENST00000261435.6	+	16	5397	c.4981C>G	c.(4981-4983)Ctt>Gtt	p.L1661V		NM_018177.4	NP_060647.2	Q86UW6	N4BP2_HUMAN	NEDD4 binding protein 2	1661						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			breast(4)|endometrium(3)|kidney(12)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	60						TTAGGGTACTCTTCATGAGCA	0.428000													24	62					0	0	0.717897	0	0
MAPK15	225689	broad.mit.edu	37	8	144803789	144803789	+	Silent	SNP	G	G	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr8:144803789G>T	ENST00000338033.4	+	12	1394	c.1275G>T	c.(1273-1275)ggG>ggT	p.G425G		NM_139021.2	NP_620590.2	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	425					protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|stomach(1)	12	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CTCTCCTAGGGAATGGGGAAA	0.662000													60	64					2.41358e-16	2.59043e-16	0.870114	1	0
PDXDC2P	283970	broad.mit.edu	37	16	70010650	70010650	+	RNA	SNP	A	A	G	rs144900726	by1000genomes	TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr16:70010650A>G	ENST00000531894.1	-	0	3748					NR_003610.1																						AGGGCCGAAGAAGGGAATGTT	0.468000													4	111					0	0	0.184627	0	0
FAT4	79633	broad.mit.edu	37	4	126239282	126239282	+	Silent	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126239282C>G	ENST00000394329.3	+	1	1729	c.1716C>G	c.(1714-1716)ctC>ctG	p.L572L		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	572	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TAGTAACTCTCCTAGATGTGA	0.498000											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	44					0	0	0.575678	0	0
PTPRS	5802	broad.mit.edu	37	19	5244216	5244216	+	Silent	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr19:5244216G>A	ENST00000372412.4	-	11	1502	c.1269C>T	c.(1267-1269)ggC>ggT	p.G423G	PTPRS_ENST00000592099.1_Silent_p.G409G|PTPRS_ENST00000588012.1_Silent_p.G409G|PTPRS_ENST00000357368.4_Silent_p.G422G|PTPRS_ENST00000348075.2_Silent_p.G409G|PTPRS_ENST00000588552.1_5'UTR|PTPRS_ENST00000353284.2_Silent_p.G409G|PTPRS_ENST00000587303.1_Silent_p.G422G|PTPRS_ENST00000262963.6_Silent_p.G418G			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	422					cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GGGCCTGCTCGCCTGTGCGGG	0.711000													21	86					0	0	0.624587	0	0
MYOF	26509	broad.mit.edu	37	10	95123738	95123738	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr10:95123738C>T	ENST00000371501.4	-	27	2970	c.2848G>A	c.(2848-2850)Gag>Aag	p.E950K	MYOF_ENST00000358334.5_Missense_Mutation_p.E937K|MYOF_ENST00000359263.4_Missense_Mutation_p.E950K|MYOF_ENST00000371502.4_Missense_Mutation_p.E950K			Q9NZM1	MYOF_HUMAN	myoferlin	950					blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						TAGGTGTCCTCGGCCGGCTTC	0.612000													70	63					0	0	0.870114	0	0
FAM162A	26355	broad.mit.edu	37	3	122123148	122123148	+	Silent	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:122123148G>A	ENST00000477892.1	+	3	285	c.201G>A	c.(199-201)caG>caA	p.Q67Q	FAM162A_ENST00000232125.5_Silent_p.Q57Q|FAM162A_ENST00000469967.1_Silent_p.Q67Q	NM_014367.3	NP_055182.3	Q96A26	F162A_HUMAN	family with sequence similarity 162, member A	67						integral to membrane				breast(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)	6						CGGATTGGCAGAAAAAGATCC	0.373000													9	20					0	0	0.361761	0	0
CSMD3	114788	broad.mit.edu	37	8	113241090	113241090	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr8:113241090G>T	ENST00000297405.5	-	70	11103	c.10859C>A	c.(10858-10860)tCa>tAa	p.S3620*	CSMD3_ENST00000352409.3_Nonsense_Mutation_p.S3550*|CSMD3_ENST00000455883.2_Nonsense_Mutation_p.S3451*|CSMD3_ENST00000343508.3_Nonsense_Mutation_p.S3580*	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3620						integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AGGTTGATTTGAAGAATTTGA	0.279000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			15	18					1.20859e-23	1.31991e-23	0.557998	1	0
PSG3	5671	broad.mit.edu	37	19	43236936	43236936	+	Splice_Site	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr19:43236936G>A	ENST00000327495.5	-	3	893	c.709C>T	c.(709-711)Ccg>Tcg	p.P237S	PSG3_ENST00000595140.1_Splice_Site_p.P237S	NM_021016.3	NP_066296.2	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	237					defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36		Prostate(69;0.00682)				AGATACTCACGGAGGAGATTC	0.542000													141	277					0	0	0.870114	0	0
ZNF141	7700	broad.mit.edu	37	4	367226	367226	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:367226A>G	ENST00000240499.7	+	4	1149	c.1000A>G	c.(1000-1002)Act>Gct	p.T334A	ZNF141_ENST00000512994.1_Intron|ZNF141_ENST00000505939.1_Intron	NM_003441.2	NP_003432.1	Q15928	ZN141_HUMAN	zinc finger protein 141	334					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(3)|large_intestine(5)|lung(8)|upper_aerodigestive_tract(1)	18						GAGAATTCATACTGGAGAGAA	0.398000													3	59					0	0	0.115264	0	0
FAT4	79633	broad.mit.edu	37	4	126240826	126240826	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126240826C>G	ENST00000394329.3	+	1	3273	c.3260C>G	c.(3259-3261)aCt>aGt	p.T1087S		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1087	Cadherin 10.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GTGAATGTTACTGTAATTTTA	0.393000													38	100					0	0	0.864702	0	0
AMZ1	155185	broad.mit.edu	37	7	2749415	2749415	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr7:2749415C>A	ENST00000312371.4	+	6	1281	c.913C>A	c.(913-915)Cat>Aat	p.H305N	AMZ1_ENST00000407112.1_Missense_Mutation_p.A248E|AMZ1_ENST00000489665.1_3'UTR	NM_133463.1	NP_597720.1	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	305							metallopeptidase activity|zinc ion binding			breast(2)|kidney(1)|large_intestine(4)|lung(8)|skin(1)	16		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		GAAGCTGCAGCATGTCCTGGG	0.701000											OREG0017838	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	31					2.4624e-09	2.58707e-09	0.575678	1	0
PHKG2	5261	broad.mit.edu	37	16	30764566	30764566	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr16:30764566G>A	ENST00000563588.1	+	5	579	c.340G>A	c.(340-342)Gag>Aag	p.E114K	PHKG2_ENST00000424889.3_Missense_Mutation_p.E114K|PHKG2_ENST00000328273.7_Missense_Mutation_p.E114K	NM_000294.2	NP_000285.1	P15735	PHKG2_HUMAN	phosphorylase kinase, gamma 2 (testis)	114	Protein kinase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	ATP binding|calmodulin binding|phosphorylase kinase activity			ovary(1)|skin(1)	2			Colorectal(24;0.198)			GCGGAAGGGAGAGCTGTTTGA	0.552000													13	39					0	0	0.500413	0	0
SAR1B	51128	broad.mit.edu	37	5	133942733	133942733	+	Silent	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr5:133942733C>G	ENST00000402673.2	-	7	782	c.504G>C	c.(502-504)ctG>ctC	p.L168L	SAR1B_ENST00000509937.1_Silent_p.L100L|SAR1B_ENST00000439578.1_Silent_p.L168L|SAR1B_ENST00000502539.1_Silent_p.L100L|SAR1B_ENST00000507419.1_Silent_p.L100L	NM_016103.3	NP_057187.1	Q9Y6B6	SAR1B_HUMAN	SAR1 homolog B (S. cerevisiae)	168					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi cisterna membrane	GTP binding|GTPase activity|metal ion binding			kidney(2)|lung(2)|urinary_tract(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GTCGGGCATTCAGTTCTTTCA	0.403000													24	62					0	0	0.717897	0	0
FAT4	79633	broad.mit.edu	37	4	126240499	126240499	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126240499C>A	ENST00000394329.3	+	1	2946	c.2933C>A	c.(2932-2934)tCt>tAt	p.S978Y		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	978	Cadherin 9.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CAGCTCTCCTCTAGTGTCATC	0.453000													22	55					4.26978e-12	4.52415e-12	0.654019	1	0
CLDN1	9076	broad.mit.edu	37	3	190026071	190026071	+	Missense_Mutation	SNP	C	C	G	rs147881276		TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:190026071C>G	ENST00000295522.3	-	4	899	c.631G>C	c.(631-633)Gtg>Ctg	p.V211L		NM_021101.4	NP_066924.1	O95832	CLD1_HUMAN	claudin 1	211	Interactions with TJP1, TJP2, TJP3 and INADL (By similarity).				calcium-independent cell-cell adhesion|interspecies interaction between organisms	integral to plasma membrane|tight junction	identical protein binding|structural molecule activity			lung(9)	9	all_cancers(143;2.95e-10)|Ovarian(172;0.0512)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.015)		CTGTGTCACACGTAGTCTTTC	0.448000													22	150					0	0	0.750413	0	0
RTCA	8634	broad.mit.edu	37	1	100756986	100756986	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:100756986G>C	ENST00000370128.4	+	11	1196	c.1027G>C	c.(1027-1029)Gat>Cat	p.D343H	RTCA_ENST00000260563.4_Missense_Mutation_p.D356H	NM_003729.3	NP_003720.1	O00442	RTC1_HUMAN	RNA 3'-terminal phosphate cyclase	343					RNA processing	mitochondrion|nucleoplasm	ATP binding|protein binding|RNA binding|RNA-3'-phosphate cyclase activity										GAAATCAGAAGATGAAGAAGA	0.358000													13	51					0	0	0.500413	0	0
TTN	7273	broad.mit.edu	37	2	179436844	179436844	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:179436844G>T	ENST00000589042.1	-	326	74239	c.74015C>A	c.(74014-74016)aCt>aAt	p.T24672N	TTN_ENST00000460472.2_Missense_Mutation_p.T15607N|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.T15799N|TTN_ENST00000591111.1_Missense_Mutation_p.T23031N|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.T22104N|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.T15732N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	23031	Fibronectin type-III 79.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTGGCTTCAGTGACCTTGAC	0.478000													13	22					1.02788e-11	1.0845e-11	0.520397	1	0
CYP4B1	1580	broad.mit.edu	37	1	47283813	47283813	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:47283813C>G	ENST00000271153.4	+	11	1316	c.1280C>G	c.(1279-1281)tCt>tGt	p.S427C	CYP4B1_ENST00000371919.4_Missense_Mutation_p.S413C|CYP4B1_ENST00000371923.4_Missense_Mutation_p.S428C|CYP4B1_ENST00000452782.2_Missense_Mutation_p.S265C			P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B, polypeptide 1	427					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding	p.S427F(1)		NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	36	Acute lymphoblastic leukemia(166;0.155)					GTCTTTGACTCTCTGCGCTTT	0.582000													16	107					0	0	0.557998	0	0
FBN1	2200	broad.mit.edu	37	15	48888548	48888548	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr15:48888548C>G	ENST00000316623.5	-	6	925	c.470G>C	c.(469-471)gGa>gCa	p.G157A		NM_000138.4	NP_000129	P35555	FBN1_HUMAN	fibrillin 1	157	EGF-like 3.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		ACACCTTCCTCCATTGAGACA	0.418000													3	60					0	0	0.150653	0	0
NOB1	28987	broad.mit.edu	37	16	69776286	69776286	+	Silent	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr16:69776286C>T	ENST00000268802.5	-	9	1217	c.1188G>A	c.(1186-1188)cgG>cgA	p.R396R	CTD-2033A16.3_ENST00000575838.1_RNA	NM_014062.1	NP_054781.1	Q9ULX3	NOB1_HUMAN	NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)	396						nucleus	metal ion binding|protein binding	p.R396R(1)		breast(2)|cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						TTAAGCGTCTCCGCCCAGCTC	0.587000													11	37					0	0	0.457914	0	0
TNN	63923	broad.mit.edu	37	1	175066815	175066815	+	Silent	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:175066815G>A	ENST00000239462.4	+	8	1964	c.1851G>A	c.(1849-1851)ccG>ccA	p.P617P		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	617	Fibronectin type-III 4.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CCAACGCCCCGACAGGTAACA	0.512000													4	94					0	0	0.217242	0	0
FOXO3	2309	broad.mit.edu	37	6	108984897	108984897	+	Silent	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr6:108984897G>A	ENST00000406360.1	+	2	1204	c.861G>A	c.(859-861)caG>caA	p.Q287Q	FOXO3_ENST00000540898.1_Silent_p.Q67Q|FOXO3_ENST00000343882.6_Silent_p.Q287Q	NM_001455.3	NP_001446.1	O43524	FOXO3_HUMAN	forkhead box O3	287					antral ovarian follicle growth|apoptosis|embryo development|glucose homeostasis|induction of apoptosis|initiation of primordial ovarian follicle growth|insulin receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|oocyte maturation|ovulation from ovarian follicle|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			central_nervous_system(5)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	26		all_cancers(87;1.78e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;3.88e-05)|Colorectal(196;0.0294)|all_lung(197;0.0487)|Lung SC(18;0.152)		Epithelial(106;0.000759)|all cancers(137;0.00121)|BRCA - Breast invasive adenocarcinoma(108;0.00163)|OV - Ovarian serous cystadenocarcinoma(136;0.00718)		GTCCCTCCCAGCTCTCCAAGT	0.597000													12	18					0	0	0.539581	0	0
HEXIM1	10614	broad.mit.edu	37	17	43226833	43226833	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:43226833G>C	ENST00000332499.2	+	1	2150	c.276G>C	c.(274-276)caG>caC	p.Q92H		NM_006460.2	NP_006451.1	O94992	HEXI1_HUMAN	hexamethylene bis-acetamide inducible 1	92					negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding			breast(1)|kidney(2)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						AGAAGGGCCAGAATGGGGACG	0.682000											OREG0024474	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	29					0	0	0.150653	0	0
SCAF4	57466	broad.mit.edu	37	21	33043774	33043774	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr21:33043774C>T	ENST00000286835.7	-	20	3764	c.3382G>A	c.(3382-3384)Gag>Aag	p.E1128K	SCAF4_ENST00000399804.1_Missense_Mutation_p.E1106K|SCAF4_ENST00000434667.3_Missense_Mutation_p.E1113K	NM_020706.2	NP_065757.1	O95104	SFR15_HUMAN	SR-related CTD-associated factor 4	1128						nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(11)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						GAGGTAGCCTCAGCAGGTAAC	0.498000													12	36					0	0	0.500413	0	0
PDPR	55066	broad.mit.edu	37	16	70190728	70190728	+	Silent	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr16:70190728C>T	ENST00000288050.4	+	19	3543	c.2586C>T	c.(2584-2586)ttC>ttT	p.F862F	PDPR_ENST00000542659.1_Silent_p.F207F|PDPR_ENST00000568530.1_Silent_p.F862F|RP11-296I10.3_ENST00000566989.1_RNA|PDPR_ENST00000562100.1_3'UTR|PDPR_ENST00000567046.1_Silent_p.F220F|PDPR_ENST00000398122.3_Silent_p.F762F	NM_017990.3	NP_060460.4	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory subunit	862					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|skin(2)|stomach(3)	33				BRCA - Breast invasive adenocarcinoma(221;0.124)		CCTCCCTCTTCACCCAGAAGC	0.562000													4	30					0	0	0.217242	0	0
TDRD6	221400	broad.mit.edu	37	6	46657989	46657989	+	Silent	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr6:46657989G>A	ENST00000544460.1	+	1	2378	c.2124G>A	c.(2122-2124)caG>caA	p.Q708Q	TDRD6_ENST00000316081.6_Silent_p.Q708Q	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	708					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			AAGGAGAGCAGAAAGCCAAGA	0.408000													15	24					0	0	0.539581	0	0
SNX22	79856	broad.mit.edu	37	15	64446167	64446167	+	Silent	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr15:64446167C>T	ENST00000325881.4	+	6	485	c.426C>T	c.(424-426)ttC>ttT	p.F142F		NM_024798.2	NP_079074.2	Q96L94	SNX22_HUMAN	sorting nexin 22	142					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding			large_intestine(3)|lung(1)|urinary_tract(2)	6						TCCTGAGCTTCCATGTGGATC	0.612000											OREG0023180	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	176					0	0	0.859065	0	0
UROC1	131669	broad.mit.edu	37	3	126202223	126202223	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:126202223C>G	ENST00000290868.2	-	19	1932	c.1879G>C	c.(1879-1881)Gtc>Ctc	p.V627L	UROC1_ENST00000383579.3_Missense_Mutation_p.V687L	NM_144639.2	NP_653240.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1	627					histidine catabolic process	cytosol	urocanate hydratase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(1)|skin(1)	39				GBM - Glioblastoma multiforme(114;0.17)		CCATTGGAGACATCCCAGCTG	0.617000													6	43					0	0	0.217242	0	0
SEC24B	10427	broad.mit.edu	37	4	110415839	110415839	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:110415839C>T	ENST00000265175.5	+	6	1370	c.1315C>T	c.(1315-1317)Cca>Tca	p.P439S	SEC24B_ENST00000399100.2_Missense_Mutation_p.P404S|SEC24B_ENST00000504968.2_Missense_Mutation_p.P470S	NM_006323.2	NP_006314.2	O95487	SC24B_HUMAN	SEC24 family member B	439					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			breast(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		TGCTTCTGCTCCAGCTCCAGC	0.488000													40	107					0	0	0.870114	0	0
AGPS	8540	broad.mit.edu	37	2	178402841	178402841	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:178402841C>G	ENST00000264167.4	+	20	2041	c.1895C>G	c.(1894-1896)tCt>tGt	p.S632C	AGPS_ENST00000409888.1_Missense_Mutation_p.S163C	NM_003659.3	NP_003650.1	O00116	ADAS_HUMAN	alkylglycerone phosphate synthase	632					ether lipid biosynthetic process	peroxisomal matrix|peroxisomal membrane|plasma membrane	alkylglycerone-phosphate synthase activity|flavin adenine dinucleotide binding|oxidoreductase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0018)|Epithelial(96;0.00919)|all cancers(119;0.0358)			GAAAGTATCTCTGATGTCGGC	0.378000													25	64					0	0	0.706142	0	0
GLB1L3	112937	broad.mit.edu	37	11	134180464	134180464	+	Splice_Site	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:134180464G>C	ENST00000431683.2	+	12	1099		c.e12-1			NM_001080407.2	NP_001073876.2	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3						carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		GTGTCTTGCAGACTATGATGC	0.522000													6	17					0	0	0.278610	0	0
PARD3B	117583	broad.mit.edu	37	2	205983760	205983760	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:205983760A>C	ENST00000406610.2	+	7	1003	c.796A>C	c.(796-798)Acc>Ccc	p.T266P	PARD3B_ENST00000358768.2_Missense_Mutation_p.T266P|PARD3B_ENST00000349953.3_Missense_Mutation_p.T266P|PARD3B_ENST00000462231.1_Missense_Mutation_p.T266P|PARD3B_ENST00000351153.1_Missense_Mutation_p.T266P	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	266	PDZ 1.				cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		CGTAGACAAAACCTTTGCTCA	0.363000													17	65					0	0	0.592651	0	0
DSCAM	1826	broad.mit.edu	37	21	41450881	41450881	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr21:41450881C>T	ENST00000400454.1	-	26	4921	c.4444G>A	c.(4444-4446)Gag>Aag	p.E1482K		NM_001271534.1|NM_001389.3	NP_001258463.1|NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1482	Fibronectin type-III 6.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GCAAACAGCTCCTGCTCCTTT	0.582000													19	47					0	0	0.717897	0	0
CCDC61	729440	broad.mit.edu	37	19	46509948	46509948	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr19:46509948C>G	ENST00000263284.2	+	5	534	c.534C>G	c.(532-534)atC>atG	p.I178M	CCDC61_ENST00000595358.1_Missense_Mutation_p.I121M|CCDC61_ENST00000536603.1_Missense_Mutation_p.I121M|CCDC61_ENST00000594087.1_Missense_Mutation_p.I121M					coiled-coil domain containing 61											endometrium(3)|kidney(3)|large_intestine(1)|lung(5)|ovary(1)	13		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00221)|GBM - Glioblastoma multiforme(486;0.0233)|Epithelial(262;0.164)		GCTACCTGATCCTCATCTACT	0.652000													58	110					0	0	0.870114	0	0
ANKRD54	129138	broad.mit.edu	37	22	38234561	38234561	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr22:38234561C>T	ENST00000215941.4	-	3	613	c.421G>A	c.(421-423)Gac>Aac	p.D141N	ANKRD54_ENST00000406423.1_Missense_Mutation_p.D21N|ANKRD54_ENST00000609454.1_Intron|ANKRD54_ENST00000411961.2_Missense_Mutation_p.D125N	NM_138797.2	NP_620152.1	Q6NXT1	ANR54_HUMAN	ankyrin repeat domain 54	141										lung(1)	1	Melanoma(58;0.045)					CGGCCCTTGTCATCAGCTGCA	0.577000													9	23					0	0	0.387290	0	0
OTUD4	54726	broad.mit.edu	37	4	146059006	146059006	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:146059006G>A	ENST00000454497.2	-	21	2863	c.2726C>T	c.(2725-2727)aCt>aTt	p.T909I	OTUD4_ENST00000447906.2_Missense_Mutation_p.T974I|OTUD4_ENST00000455611.2_Intron	NM_001102653.1	NP_001096123.1	Q01804	OTUD4_HUMAN	OTU domain containing 4	973							protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33	all_hematologic(180;0.151)					AACAGGCACAGTTTCTCTCTC	0.463000													5	137					0	0	0.248553	0	0
LTF	4057	broad.mit.edu	37	3	46497843	46497843	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:46497843C>T	ENST00000231751.4	-	3	548	c.253G>A	c.(253-255)Gag>Aag	p.E85K	LTF_ENST00000417439.1_Missense_Mutation_p.E85K|LTF_ENST00000426532.2_Missense_Mutation_p.E41K	NM_002343.3	NP_002334.2	P02788	TRFL_HUMAN	lactotransferrin	85	Transferrin-like 1.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity	p.E85K(1)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	40				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	AGGCCTGCCTCGTATATGAAA	0.577000													25	84					0	0	0.796494	0	0
IL12A-AS1	101928376	broad.mit.edu	37	3	159819513	159819513	+	RNA	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:159819513G>C	ENST00000497452.1	-	0	517																											CAAAGAAAAAGAAAAAGATAC	0.483000													36	72					0	0	0.796494	0	0
PAN2	9924	broad.mit.edu	37	12	56721825	56721825	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr12:56721825A>T	ENST00000425394.2	-	5	981	c.605T>A	c.(604-606)aTg>aAg	p.M202K	PAN2_ENST00000440411.3_Missense_Mutation_p.M202K|PAN2_ENST00000257931.5_Missense_Mutation_p.M202K|PAN2_ENST00000548043.1_Missense_Mutation_p.M202K	NM_001127460.2	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	202					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						TGTCTGTCTCATGATGGTGAC	0.507000													6	33					0	0	0.248553	0	0
PKP2	5318	broad.mit.edu	37	12	32977077	32977077	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr12:32977077C>T	ENST00000340811.4	-	7	1684	c.1576G>A	c.(1576-1578)Gct>Act	p.A526T	PKP2_ENST00000070846.6_Missense_Mutation_p.A570T	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2	570			T -> M.		cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					CTCCCATCAGCGCCAGCAGAA	0.413000													23	40					0	0	0.667858	0	0
CDH26	60437	broad.mit.edu	37	20	58545159	58545159	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr20:58545159G>A	ENST00000348616.4	+	3	449	c.149G>A	c.(148-150)cGg>cAg	p.R50Q	CDH26_ENST00000244047.5_Missense_Mutation_p.R50Q	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	50	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			CAGCCTCTACGGCGATCCAAG	0.498000													42	98					0	0	0.870114	0	0
BAGE2	85319	broad.mit.edu	37	21	11038869	11038869	+	RNA	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr21:11038869G>C	ENST00000470054.1	-	0	1334									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GGGTAATTACGCAGCATGTCA	0.443000													5	265					0	0	0.557998	0	0
NR3C1	2908	broad.mit.edu	37	5	142680325	142680325	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr5:142680325C>T	ENST00000343796.2	-	5	2465	c.1472G>A	c.(1471-1473)cGa>cAa	p.R491Q	NR3C1_ENST00000394466.2_Missense_Mutation_p.R492Q|NR3C1_ENST00000504572.1_Missense_Mutation_p.R492Q|NR3C1_ENST00000416954.2_Missense_Mutation_p.R94Q|NR3C1_ENST00000231509.3_Missense_Mutation_p.R492Q|NR3C1_ENST00000504336.1_5'UTR|NR3C1_ENST00000394464.2_Missense_Mutation_p.R491Q|NR3C1_ENST00000415690.2_Missense_Mutation_p.R491Q|NR3C1_ENST00000424646.2_Missense_Mutation_p.R465Q|NR3C1_ENST00000503201.1_Missense_Mutation_p.R491Q	NM_001018074.1|NM_001018075.1|NM_001018077.1	NP_001018084.1|NP_001018085.1|NP_001018087.1	P04150	GCR_HUMAN	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	491	Hinge.				chromatin modification|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus|transcription from RNA polymerase II promoter	mitochondrial matrix|nucleoplasm	glucocorticoid receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	35		Acute lymphoblastic leukemia(2;3.2e-05)|all_hematologic(2;0.000361)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)		Amcinonide(DB00288)|Betamethasone(DB00443)|Budesonide(DB01222)|Dexamethasone(DB01234)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluticasone Propionate(DB00588)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mifepristone(DB00834)|Mometasone(DB00764)|Prednisone(DB00635)	CTTTGTTTTTCGAGCTGTGGG	0.348000													3	7					0	0	0.115264	0	0
C20orf96	140680	broad.mit.edu	37	20	259903	259903	+	Silent	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr20:259903G>A	ENST00000360321.2	-	5	513	c.375C>T	c.(373-375)ctC>ctT	p.L125L	C20orf96_ENST00000400269.3_Silent_p.L67L|C20orf96_ENST00000382369.5_Silent_p.L90L	NM_080571.1|NM_153269.2	NP_542138.1|NP_695001.2	Q9NUD7	CT096_HUMAN	chromosome 20 open reading frame 96	125										endometrium(3)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	12		all_cancers(10;0.00959)|Lung NSC(37;0.227)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			GCTCCCGGTTGAGCTTGCTGA	0.672000													23	187					0	0	0.693898	0	0
GRIN2D	2906	broad.mit.edu	37	19	48945175	48945175	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr19:48945175G>A	ENST00000263269.3	+	11	2490	c.2402G>A	c.(2401-2403)cGg>cAg	p.R801Q		NM_000836.2	NP_000827.2	O15399	NMDE4_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	801						cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			autonomic_ganglia(1)|breast(6)|endometrium(2)|large_intestine(9)|lung(12)|ovary(5)|pancreas(1)|prostate(1)	37		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	CGCTGGAAGCGGCCCATCGAC	0.672000													3	37					0	0	0.150653	0	0
PDXDC2P	283970	broad.mit.edu	37	16	70010646	70010646	+	RNA	SNP	G	G	A	rs149870591	by1000genomes	TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr16:70010646G>A	ENST00000531894.1	-	0	3748					NR_003610.1																						CTGTAGGGCCGAAGAAGGGAA	0.478000													4	121					0	0	0.150653	0	0
PPARD	5467	broad.mit.edu	37	6	35392554	35392554	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr6:35392554G>C	ENST00000311565.4	+	8	1425	c.1076G>C	c.(1075-1077)gGa>gCa	p.G359A	PPARD_ENST00000337400.2_Missense_Mutation_p.G359A|PPARD_ENST00000448077.2_Missense_Mutation_p.G320A|PPARD_ENST00000418635.2_Missense_Mutation_p.G261A|PPARD_ENST00000360694.3_Missense_Mutation_p.G359A|PPARD_ENST00000444397.1_Missense_Mutation_p.G359A|PPARD_ENST00000540939.1_Missense_Mutation_p.G256A	NM_001171818.1	NP_001165289.1	Q03181	PPARD_HUMAN	peroxisome proliferator-activated receptor delta	359	Ligand-binding.				apoptosis|axon ensheathment|cholesterol metabolic process|decidualization|embryo implantation|fatty acid beta-oxidation|fatty acid transport|generation of precursor metabolites and energy|glucose metabolic process|glucose transport|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|linoleic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(4)|liver(2)|lung(9)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23					Icosapent(DB00159)|Sulindac(DB00605)|Treprostinil(DB00374)	ATTCTGTGTGGAGGTGAGTGA	0.562000													15	22					0	0	0.575678	0	0
STAG2	10735	broad.mit.edu	37	X	123185061	123185061	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chrX:123185061C>T	ENST00000371160.1	+	12	1398	c.1108C>T	c.(1108-1110)Cgg>Tgg	p.R370W	STAG2_ENST00000371145.3_Missense_Mutation_p.R370W|STAG2_ENST00000354548.5_Missense_Mutation_p.R301W|STAG2_ENST00000469481.1_Intron|STAG2_ENST00000371144.3_Missense_Mutation_p.R370W|STAG2_ENST00000218089.9_Missense_Mutation_p.R370W|STAG2_ENST00000371157.3_Missense_Mutation_p.R370W	NM_001282418.1	NP_001269347.1	Q8N3U4	STAG2_HUMAN	stromal antigen 2	370	SCD.				cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding	p.R370G(1)|p.R370W(1)		breast(5)|central_nervous_system(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(9)|lung(21)|ovary(5)|prostate(2)|skin(5)|urinary_tract(4)	78						TTTTACCAGTCGGTTCAAGGT	0.294000													4	5					0	0	0.184627	0	0
FAH	2184	broad.mit.edu	37	15	80465390	80465390	+	Silent	SNP	C	C	T	rs145851627		TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr15:80465390C>T	ENST00000539156.1	+	8	2769	c.531C>T	c.(529-531)ctC>ctT	p.L177L	FAH_ENST00000261755.5_Silent_p.L247L|FAH_ENST00000407106.1_Silent_p.L247L|FAH_ENST00000561421.1_Silent_p.L247L|FAH_ENST00000558627.1_3'UTR			P16930	FAAA_HUMAN	fumarylacetoacetate hydrolase (fumarylacetoacetase)	247					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	fumarylacetoacetase activity|metal ion binding	p.L247L(1)		endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						ATGTCCCTCTCGGGCCATTCC	0.572000									Tyrosinemia, type 1		OREG0023354	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	88					0	0	0.639603	0	0
PHLPP1	23239	broad.mit.edu	37	18	60642723	60642723	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr18:60642723G>C	ENST00000400316.4	+	16	4094	c.2313G>C	c.(2311-2313)ttG>ttC	p.L771F	PHLPP1_ENST00000262719.5_Missense_Mutation_p.L1283F	NM_194449.3	NP_919431.2	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein phosphatase 1	1283					apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity			endometrium(2)|kidney(2)|lung(13)	17						CCTTCACCTTGACCTCTGCTA	0.507000													27	91					0	0	0.740014	0	0
TMEM150B	284417	broad.mit.edu	37	19	55828287	55828287	+	Silent	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr19:55828287G>A	ENST00000326652.4	-	7	554	c.372C>T	c.(370-372)ttC>ttT	p.F124F	TMEM150B_ENST00000438693.1_Silent_p.F124F	NM_001282011.1	NP_001268940.1	A6NC51	T150B_HUMAN	transmembrane protein 150B	124						integral to membrane				endometrium(1)|large_intestine(1)|lung(1)	3						TACCCAAGATGAAGGCAAGGA	0.637000													6	14					0	0	0.278610	0	0
TAZ	6901	broad.mit.edu	37	X	153640483	153640483	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chrX:153640483G>A	ENST00000299328.5	+	2	459	c.170G>A	c.(169-171)cGa>cAa	p.R57Q	TAZ_ENST00000369776.4_Intron|TAZ_ENST00000351413.4_Missense_Mutation_p.R57Q|TAZ_ENST00000350743.4_Missense_Mutation_p.R57Q|TAZ_ENST00000369790.4_Missense_Mutation_p.R57Q|TAZ_ENST00000475699.1_Missense_Mutation_p.R57Q	NM_000116.3	NP_000107.1	Q16635	TAZ_HUMAN	tafazzin	57					cardiac muscle contraction|cardiac muscle tissue development|cardiolipin biosynthetic process|cristae formation|hemopoiesis|mitochondrial ATP synthesis coupled electron transport|mitochondrial respiratory chain complex I assembly|skeletal muscle tissue development	integral to membrane|mitochondrion	1-acylglycerophosphocholine O-acyltransferase activity			lung(1)	1	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ATCGAGAAGCGAGGCCCGGCC	0.662000											OREG0003602	type=REGULATORY REGION|Gene=DNASE1L1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	14	6					0	0	0.500413	0	0
APOBEC1	339	broad.mit.edu	37	12	7805382	7805382	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr12:7805382G>T	ENST00000229304.4	-	3	114	c.94C>A	c.(94-96)Ctt>Att	p.L32I		NM_001644.3	NP_001635.2	P41238	ABEC1_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	32					cytidine to uridine editing|DNA demethylation|lipid metabolic process|mRNA modification|mRNA processing|negative regulation of methylation-dependent chromatin silencing	nucleoplasm	cytidine deaminase activity|RNA binding|zinc ion binding			kidney(2)|large_intestine(2)|lung(10)|prostate(1)|skin(1)|stomach(1)	17						TCTTTACGAAGTTCTCTGGGG	0.478000													20	54					2.24059e-21	2.43628e-21	0.706142	1	0
ARRDC3	57561	broad.mit.edu	37	5	90670966	90670966	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr5:90670966C>G	ENST00000265138.3	-	5	909	c.643G>C	c.(643-645)Gag>Cag	p.E215Q		NM_020801.2	NP_065852.1	Q96B67	ARRD3_HUMAN	arrestin domain containing 3	215					signal transduction	cytoplasm	protein binding			breast(2)|endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|urinary_tract(1)	18		all_cancers(142;2.22e-05)|all_epithelial(76;1.58e-07)|all_lung(232;0.000521)|Lung NSC(167;0.000548)|Ovarian(174;0.0798)|Colorectal(57;0.207)		OV - Ovarian serous cystadenocarcinoma(54;4.56e-30)|Epithelial(54;7.55e-26)|all cancers(79;3.63e-22)		GAGCAGTTCTCAATCTCAGCA	0.388000													4	33					0	0	0.150653	0	0
MTR	4548	broad.mit.edu	37	1	236978926	236978926	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:236978926A>G	ENST00000366577.5	+	7	1026	c.632A>G	c.(631-633)aAt>aGt	p.N211S	MTR_ENST00000418145.2_3'UTR|MTR_ENST00000535889.1_Missense_Mutation_p.N211S	NM_000254.2	NP_000245.2	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase	211	Hcy-binding.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	67	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	GCACTCCAAAATCTTTTTGAG	0.363000													17	50					0	0	0.624587	0	0
TOB1	10140	broad.mit.edu	37	17	48941096	48941096	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:48941096C>T	ENST00000499247.2	-	2	716	c.283G>A	c.(283-285)Gac>Aac	p.D95N	TOB1_ENST00000509385.1_5'UTR|TOB1_ENST00000268957.3_Missense_Mutation_p.D95N	NM_001243885.1|NM_005749.3	NP_001230814.1|NP_005740.1	P50616	TOB1_HUMAN	transducer of ERBB2, 1	95					negative regulation of cell proliferation		SH3/SH2 adaptor activity			breast(1)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			TCAAATGGGTCGATCCAAACA	0.428000											OREG0024576	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	73					0	0	0.307466	0	0
CCDC88A	55704	broad.mit.edu	37	2	55522809	55522809	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:55522809C>G	ENST00000436346.1	-	31	6316	c.5475G>C	c.(5473-5475)ttG>ttC	p.L1825F	CCDC88A_ENST00000422883.2_Missense_Mutation_p.L326F|CCDC88A_ENST00000263630.8_Missense_Mutation_p.L1797F|CCDC88A_ENST00000336838.6_Missense_Mutation_p.L1824F|CCDC88A_ENST00000413716.2_Missense_Mutation_p.L1750F	NM_001135597.1|NM_001254943.1	NP_001129069.1|NP_001241872.1	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A	1825					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(22)|lung(23)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	69						TGTCCTTGGTCAAAAAATCAT	0.458000													43	147					0	0	0.870114	0	0
ESRP1	54845	broad.mit.edu	37	8	95655543	95655543	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr8:95655543G>A	ENST00000433389.2	+	3	464	c.274G>A	c.(274-276)Gtg>Atg	p.V92M	ESRP1_ENST00000423620.2_Missense_Mutation_p.V92M|ESRP1_ENST00000358397.5_Missense_Mutation_p.V92M|ESRP1_ENST00000454170.2_Missense_Mutation_p.V92M	NM_001034915.2|NM_017697.3	NP_001030087.2|NP_060167.2	Q6NXG1	ESRP1_HUMAN	epithelial splicing regulatory protein 1	92					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	NS(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(2)	20						TAACCAGTCAGTGAGCAATGA	0.453000													4	87					0	0	0.184627	0	0
CCDC33	80125	broad.mit.edu	37	15	74554886	74554886	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr15:74554886G>C	ENST00000321288.5	+	5	900	c.900G>C	c.(898-900)gaG>gaC	p.E300D	CCDC33_ENST00000398814.3_Missense_Mutation_p.E97D			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	300	C2.						protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						TGAATGTGGAGATCCAAGCTG	0.572000													10	12					0	0	0.387290	0	0
SCGB2A1	4246	broad.mit.edu	37	11	61978051	61978051	+	Silent	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:61978051G>A	ENST00000244930.4	+	2	286	c.222G>A	c.(220-222)ctG>ctA	p.L74L		NM_002407.2	NP_002398.1	O75556	SG2A1_HUMAN	secretoglobin, family 2A, member 1	74						extracellular region	androgen binding			breast(1)|kidney(1)|large_intestine(2)|lung(2)	6						ATAGAACTCTGAAAAACTTTG	0.418000													15	41					0	0	0.520397	0	0
SLC34A2	10568	broad.mit.edu	37	4	25664188	25664188	+	Silent	SNP	A	A	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:25664188A>G	ENST00000382051.3	+	2	116	c.66A>G	c.(64-66)gcA>gcG	p.A22A	SLC34A2_ENST00000503434.1_Silent_p.A22A|SLC34A2_ENST00000504570.1_Silent_p.A22A	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	22					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				AAGGGGCCGCAGGTCAGCAGC	0.547000			T	ROS1	NSCLC								3	102					0	0	0.184627	0	0
LIG3	3980	broad.mit.edu	37	17	33318055	33318055	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:33318055G>C	ENST00000378526.4	+	5	1096	c.963G>C	c.(961-963)ttG>ttC	p.L321F	LIG3_ENST00000262327.5_Missense_Mutation_p.L321F	NM_013975.3	NP_039269.2	P49916	DNLI3_HUMAN	ligase III, DNA, ATP-dependent	321					base-excision repair|cell division|DNA ligation involved in DNA repair|DNA replication|reciprocal meiotic recombination|spermatogenesis	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|protein binding|zinc ion binding			endometrium(4)|large_intestine(8)|lung(9)|ovary(3)|pancreas(2)|prostate(1)|skin(3)|stomach(1)	31		Ovarian(249;0.17)			Bleomycin(DB00290)	TTTACAACTTGAACGATAAGC	0.488000								Other BER factors					35	66					0	0	0.827153	0	0
FAT4	79633	broad.mit.edu	37	4	126239473	126239473	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126239473C>T	ENST00000394329.3	+	1	1920	c.1907C>T	c.(1906-1908)cCt>cTt	p.P636L		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	636	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CGTCTGGATCCTGTGTCTGGG	0.567000													21	34					0	0	0.608945	0	0
SESN1	27244	broad.mit.edu	37	6	109308772	109308772	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr6:109308772C>G	ENST00000436639.2	-	10	2376	c.1631G>C	c.(1630-1632)aGa>aCa	p.R544T	SESN1_ENST00000356644.7_Missense_Mutation_p.R485T|SESN1_ENST00000302071.2_Missense_Mutation_p.R419T	NM_014454.2	NP_055269.1	Q9Y6P5	SESN1_HUMAN	sestrin 1	485					cell cycle arrest|negative regulation of cell proliferation|response to DNA damage stimulus	nucleus				cervix(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	10		all_cancers(87;6.45e-05)|Acute lymphoblastic leukemia(125;3.55e-10)|all_hematologic(75;1.68e-07)|all_epithelial(87;0.0106)|Colorectal(196;0.0637)		Epithelial(106;0.0014)|BRCA - Breast invasive adenocarcinoma(108;0.00146)|all cancers(137;0.0031)|OV - Ovarian serous cystadenocarcinoma(136;0.0117)		GGTAATGGCTCTCAGAGCATA	0.398000													20	55					0	0	0.706142	0	0
FAT4	79633	broad.mit.edu	37	4	126239780	126239780	+	Silent	SNP	C	C	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126239780C>A	ENST00000394329.3	+	1	2227	c.2214C>A	c.(2212-2214)gtC>gtA	p.V738V		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	738	Cadherin 7.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GGTTTCAGGTCAATGCTCAGA	0.453000													15	39					3.27435e-08	3.42569e-08	0.457914	1	0
DEPDC5	9681	broad.mit.edu	37	22	32242914	32242914	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr22:32242914C>T	ENST00000400246.1	+	31	3258	c.3116C>T	c.(3115-3117)tCa>tTa	p.S1039L	DEPDC5_ENST00000400249.2_Missense_Mutation_p.S1030L|DEPDC5_ENST00000266091.3_Missense_Mutation_p.S1039L|DEPDC5_ENST00000382112.3_Missense_Mutation_p.S1030L|DEPDC5_ENST00000382105.2_Missense_Mutation_p.S961L|DEPDC5_ENST00000400248.2_Missense_Mutation_p.S1030L|DEPDC5_ENST00000535622.1_Missense_Mutation_p.S961L|DEPDC5_ENST00000382111.2_Missense_Mutation_p.S1039L			O75140	DEPD5_HUMAN	DEP domain containing 5	1030					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						AAGGGAACCTCAGCTCTCTCT	0.552000													14	68					0	0	0.500413	0	0
RBM10	8241	broad.mit.edu	37	X	47045491	47045491	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chrX:47045491G>A	ENST00000377604.3	+	22	3200	c.2458G>A	c.(2458-2460)Gaa>Aaa	p.E820K	RBM10_ENST00000345781.6_Missense_Mutation_p.E743K|RBM10_ENST00000329236.7_Missense_Mutation_p.E742K	NM_001204467.1|NM_001204468.1|NM_005676.4	NP_001191396.1|NP_001191397.1|NP_005667.2	P98175	RBM10_HUMAN	RNA binding motif protein 10	820					mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	48						CCGTGCAGCTGAACGCAGAGA	0.552000													16	17					0	0	0.557998	0	0
ISY1-RAB43	100534599	broad.mit.edu	37	3	128853792	128853792	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:128853792G>A	ENST00000418265.1	-	8	484	c.424C>T	c.(424-426)Cct>Tct	p.P142S	ISY1_ENST00000393295.3_Missense_Mutation_p.P142S|ISY1_ENST00000273541.8_Missense_Mutation_p.P164S|ISY1_ENST00000393292.3_Missense_Mutation_p.P142S|ISY1_ENST00000471497.1_Intron	NM_001204890.1	NP_001191819.1	Q9ULR0	ISY1_HUMAN		142						catalytic step 2 spliceosome											CTGGGAGGAGGAAGAGCTATA	0.453000													14	30					0	0	0.500413	0	0
LVRN	206338	broad.mit.edu	37	5	115320284	115320284	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr5:115320284G>T	ENST00000357872.4	+	3	980	c.856G>T	c.(856-858)Gat>Tat	p.D286Y	AQPEP_ENST00000395528.2_5'UTR	NM_173800.4	NP_776161.3	Q6Q4G3	AMPQ_HUMAN		286					proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding										TGAAAAAGAAGATGTGAATGG	0.358000													4	18					0.217242	0.219001	0.217242	1	0
IGF1R	3480	broad.mit.edu	37	15	99452048	99452048	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr15:99452048G>A	ENST00000268035.6	+	6	1993	c.1382G>A	c.(1381-1383)cGc>cAc	p.R461H	IGF1R_ENST00000558762.1_Missense_Mutation_p.R461H	NM_000875.3	NP_000866.1	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor	461					anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(13)|lung(20)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	GAAATTTACCGCATGGAGGAA	0.498000													3	25					0	0	0.184627	0	0
SLC38A10	124565	broad.mit.edu	37	17	79256117	79256117	+	Missense_Mutation	SNP	G	G	A	rs141053452	byFrequency	TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:79256117G>A	ENST00000374759.3	-	5	756	c.373C>T	c.(373-375)Cgc>Tgc	p.R125C	SLC38A10_ENST00000288439.5_Missense_Mutation_p.R125C	NM_001037984.1	NP_001033073.1	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10	125					amino acid transport|sodium ion transport	integral to membrane				NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(2)|lung(7)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			AGGAACATGCGGAAGGTGCCG	0.682000													9	16					0	0	0.335167	0	0
USP8	9101	broad.mit.edu	37	15	50782585	50782585	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr15:50782585G>C	ENST00000433963.1	+	15	2597	c.2097G>C	c.(2095-2097)aaG>aaC	p.K699N	USP8_ENST00000396444.3_Missense_Mutation_p.K699N|USP8_ENST00000307179.4_Missense_Mutation_p.K699N|USP8_ENST00000425032.3_Missense_Mutation_p.K593N			P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	699					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		ATAAAGCCAAGCCACAGATTC	0.498000													17	64					0	0	0.592651	0	0
IDH1	3417	broad.mit.edu	37	2	209104705	209104705	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:209104705C>T	ENST00000415913.1	-	8	1254	c.873G>A	c.(871-873)atG>atA	p.M291I	IDH1_ENST00000345146.2_Missense_Mutation_p.M291I|IDH1_ENST00000446179.1_Missense_Mutation_p.M291I	NM_001282387.1	NP_001269316.1	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	291					2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity			NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		GCACGCTGGTCATCATGCCGA	0.527000			Mis		gliobastoma								15	60					0	0	0.557998	0	0
ATP6AP1L	92270	broad.mit.edu	37	5	81608660	81608660	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr5:81608660T>C	ENST00000380167.4	+	9	1687	c.362T>C	c.(361-363)aTt>aCt	p.I121T	ATP6AP1L_ENST00000508366.1_3'UTR|ATP6AP1L_ENST00000439350.1_Missense_Mutation_p.I121T			Q52LC2	VAS1L_HUMAN	ATPase, H+ transporting, lysosomal accessory protein 1-like	121					ATP hydrolysis coupled proton transport	integral to membrane|proton-transporting V-type ATPase, V1 domain	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|urinary_tract(1)	12						GTCACTTTTATTGATTTCCAG	0.502000											OREG0016689	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	38					0	0	0.411799	0	0
BRINP2	57795	broad.mit.edu	37	1	177245417	177245417	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:177245417G>A	ENST00000361539.4	+	6	1171	c.859G>A	c.(859-861)Gag>Aag	p.E287K	BRINP2_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1			bone morphogenetic protein/retinoic acid inducible neural-specific 2	287																	CTCTGAGGGTGAGCTCGTCTG	0.572000													18	54					0	0	0.592651	0	0
FAT4	79633	broad.mit.edu	37	4	126238820	126238820	+	Silent	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126238820C>T	ENST00000394329.3	+	1	1267	c.1254C>T	c.(1252-1254)agC>agT	p.S418S		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	418	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CGAACCTGAGCCTAATCAAGG	0.597000											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	27					0	0	0.411799	0	0
SORCS1	114815	broad.mit.edu	37	10	108338909	108338909	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr10:108338909G>C	ENST00000344440.6	-	26	3471	c.3472C>G	c.(3472-3474)Cag>Gag	p.Q1158E	SORCS1_ENST00000369698.1_Missense_Mutation_p.Q693E|SORCS1_ENST00000263054.6_Intron	NM_001013031.2|NM_001206569.1|NM_001206571.1|NM_001206572.1	NP_001013049.1|NP_001193498.1|NP_001193500.1|NP_001193501.1	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	0						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		AGTTCAGTCTGAGGGACATTG	0.488000													33	38					0	0	0.769981	0	0
PLXNB1	5364	broad.mit.edu	37	3	48465275	48465275	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr3:48465275G>A	ENST00000358536.4	-	3	1015	c.746C>T	c.(745-747)tCt>tTt	p.S249F	PLXNB1_ENST00000358459.4_Missense_Mutation_p.S249F|PLXNB1_ENST00000456774.1_Missense_Mutation_p.S249F|PLXNB1_ENST00000296440.6_Missense_Mutation_p.S249F|PLXNB1_ENST00000448774.2_Intron	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	249	Sema.				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ACACACTCGAGATACATAGGC	0.612000													36	74					0	0	0.827153	0	0
FBXO48	554251	broad.mit.edu	37	2	68692016	68692016	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr2:68692016G>C	ENST00000377957.3	-	3	669	c.262C>G	c.(262-264)Cga>Gga	p.R88G		NM_001024680.1	NP_001019851.1	Q5FWF7	FBX48_HUMAN	F-box protein 48											endometrium(1)|large_intestine(1)|lung(1)|urinary_tract(1)	4						ATTTCTCTTCGGCACACAGCT	0.428000													23	140					0	0	0.706142	0	0
SLC22A10	387775	broad.mit.edu	37	11	63072221	63072221	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:63072221G>C	ENST00000332793.6	+	9	1460	c.1458G>C	c.(1456-1458)ttG>ttC	p.L486F	SLC22A10_ENST00000535888.1_Intron|SLC22A10_ENST00000544661.1_3'UTR|SLC22A10_ENST00000525620.1_Intron|SLC22A10_ENST00000526800.1_Intron	NM_001039752.3	NP_001034841.3	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	486						integral to membrane	transmembrane transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CTCCCCTCTTGATGACCTTAA	0.408000													11	68					0	0	0.387290	0	0
FAT4	79633	broad.mit.edu	37	4	126240753	126240753	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr4:126240753C>G	ENST00000394329.3	+	1	3200	c.3187C>G	c.(3187-3189)Caa>Gaa	p.Q1063E		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1063	Cadherin 10.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CCGTGAACTTCAAGACAGATA	0.373000													46	86					0	0	0.870114	0	0
DNAH17	8632	broad.mit.edu	37	17	76547693	76547693	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:76547693C>T	ENST00000389840.5	-	16	2439	c.2315G>A	c.(2314-2316)cGa>cAa	p.R772Q	DNAH17_ENST00000585328.1_Missense_Mutation_p.R772Q					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CAGAATTTCTCGCACCTCTTG	0.433000													7	76					0	0	0.335167	0	0
PDE3B	5140	broad.mit.edu	37	11	14839736	14839736	+	Silent	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:14839736G>A	ENST00000282096.4	+	6	1883	c.1530G>A	c.(1528-1530)ttG>ttA	p.L510L	PDE3B_ENST00000455098.2_Silent_p.L459L	NM_000922.3	NP_000913.2	Q13370	PDE3B_HUMAN	phosphodiesterase 3B, cGMP-inhibited	510					cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding			NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						AAGGTGTTTTGTCCAGTCTGA	0.323000													3	11					0	0	0.115264	0	0
ASH1L	55870	broad.mit.edu	37	1	155449087	155449087	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr1:155449087G>A	ENST00000368346.3	-	3	4213	c.3574C>T	c.(3574-3576)Cat>Tat	p.H1192Y	ASH1L_ENST00000392403.3_Missense_Mutation_p.H1192Y			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	1192					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			TCATCACTATGAGACTCACTG	0.443000													28	47					0	0	0.769981	0	0
C11orf63	79864	broad.mit.edu	37	11	122775122	122775123	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr11:122775122_122775123insA	ENST00000227349.2	+	3	1131_1132	c.834_835insA	c.(835-837)aaafs	p.K279fs	C11orf63_ENST00000307257.6_Frame_Shift_Ins_p.K279fs|C11orf63_ENST00000531316.1_Frame_Shift_Ins_p.K279fs	NM_024806.2	NP_079082.2	Q6NUN7	CK063_HUMAN	chromosome 11 open reading frame 63	279										breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(13)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	47		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		AACTTCACAATAAAAAAAGAGG	0.406													86	152	---	---	---	---					
SOX1	6656	broad.mit.edu	37	13	112722081	112722083	+	In_Frame_Del	DEL	GGC	GGC	-			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr13:112722081_112722083delGGC	ENST00000330949.1	+	1	169_171	c.109_111delGGC	c.(109-111)ggcdel	p.G43del		NM_005986.2	NP_005977.2	O00570	SOX1_HUMAN	SRY (sex determining region Y)-box 1	43	Poly-Gly.				chromatin organization	nucleus	core promoter sequence-specific DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)	4	all_lung(23;0.000652)|Lung NSC(43;0.017)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	all_cancers(25;0.000331)|Lung NSC(25;0.0496)|all_lung(25;0.0831)|all_epithelial(44;0.0868)|Breast(118;0.231)		OV - Ovarian serous cystadenocarcinoma(48;0.132)		cggaggcgggggcggcggcggcg	0.778													5	10	---	---	---	---					
UACA	55075	broad.mit.edu	37	15	70979935	70979935	+	Frame_Shift_Del	DEL	T	T	-	rs147378902		TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr15:70979935delT	ENST00000322954.6	-	7	731	c.546delA	c.(544-546)atafs	p.I182fs	UACA_ENST00000560441.1_Frame_Shift_Del_p.I169fs|UACA_ENST00000379983.2_Frame_Shift_Del_p.I169fs|UACA_ENST00000539319.1_Intron	NM_018003.2	NP_060473.2	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and ankyrin repeats	182						cytoskeleton|extracellular region				breast(2)|endometrium(7)|kidney(4)|large_intestine(13)|lung(17)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	50						GCAGTTGACATATTGTTGGCC	0.428													21	96	---	---	---	---					
RP11-863P13.2	0	broad.mit.edu	37	16	88226895	88226897	+	RNA	DEL	TGG	TGG	-	rs62047004		TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr16:88226895_88226897delTGG	ENST00000568587.1	-	0	91																											gtggtggagatggtggtggtggg	0.537													5	7	---	---	---	---					
GGA3	23163	broad.mit.edu	37	17	73239175	73239175	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr17:73239175delT	ENST00000245541.6	-	6	713	c.497delA	c.(496-498)aacfs	p.N166fs	GGA3_ENST00000537686.1_Intron|GGA3_ENST00000538886.1_Frame_Shift_Del_p.N44fs|GGA3_ENST00000582717.1_Frame_Shift_Del_p.N94fs|GGA3_ENST00000578348.1_Frame_Shift_Del_p.N44fs|GGA3_ENST00000582486.1_Frame_Shift_Del_p.N94fs|GGA3_ENST00000351904.7_Frame_Shift_Del_p.N133fs	NM_138619.2	NP_619525.1	Q9NZ52	GGA3_HUMAN	golgi-associated, gamma adaptin ear containing, ARF binding protein 3	166	Binds to ARF1 (in long isoform).				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			breast(2)|endometrium(3)|large_intestine(4)|liver(1)|lung(4)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	20			all cancers(21;2.39e-06)|Epithelial(20;2.38e-05)			AAAAACAGGGTTTTTGGGACG	0.542													7	303	---	---	---	---					
HCN2	610	broad.mit.edu	37	19	616296	616296	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr19:616296delC	ENST00000251287.2	+	8	2545	c.2492delC	c.(2491-2493)gccfs	p.A831fs	AC005559.2_ENST00000591847.1_RNA	NM_001194.3	NP_001185.3	Q9UL51	HCN2_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 2	831	Pro-rich.				cell-cell signaling|muscle contraction	voltage-gated potassium channel complex	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			endometrium(5)|lung(4)	9		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCAcggcgcccccggcccc	0.841													2	4	---	---	---	---					
CTC-513N18.7	0	broad.mit.edu	37	19	20799471	20799471	+	RNA	DEL	C	C	-			TCGA-FD-A3NA-01A-11D-A21A-08	TCGA-FD-A3NA-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d079a32c-270b-4c43-8372-884e8d0c48ed	364bca7a-3890-45cb-a284-d681100ea5e0	g.chr19:20799471delC	ENST00000595094.1	-	0	363																											ttggcaagcacccccggtctt	0.453													2	4	---	---	---	---					
