Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GAA	2548	broad.mit.edu	37	17	78082619	78082619	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:78082619A>G	ENST00000302262.3	+	8	1537	c.1318A>G	c.(1318-1320)Atg>Gtg	p.M440V	GAA_ENST00000390015.3_Missense_Mutation_p.M440V	NM_000152.3	NP_000143.2	P10253	LYAG_HUMAN	glucosidase, alpha; acid	440					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|lung(6)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	21	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	GCGCTACATGATGATCGTGGT	0.642000													7	11					0	0	1	0	0
KIAA1244	57221	broad.mit.edu	37	6	138645190	138645190	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:138645190G>C	ENST00000251691.4	+	31	5066	c.4900G>C	c.(4900-4902)Gag>Cag	p.E1634Q		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	1634					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		CAGCGGCACGGAGAGCTTCAG	0.652000													14	37					0	0	1	0	0
EED	8726	broad.mit.edu	37	11	85977208	85977208	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:85977208G>C	ENST00000263360.6	+	8	1496	c.810G>C	c.(808-810)atG>atC	p.M270I	EED_ENST00000528180.1_Intron|EED_ENST00000351625.6_Missense_Mutation_p.M270I|EED_ENST00000327320.4_Missense_Mutation_p.M270I	NM_003797.3	NP_003788.2	O75530	EED_HUMAN	embryonic ectoderm development	270	Interaction with EZH2 (By similarity).|Required for interaction with the matrix protein MA of HIV-1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	21		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				CAAAGAGAATGATGAATGCAA	0.303000													13	85					0	0	1	0	0
A1BG	1	broad.mit.edu	37	19	58862857	58862857	+	Silent	SNP	G	G	A	rs140428520		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:58862857G>A	ENST00000263100.3	-	5	871	c.810C>T	c.(808-810)gcC>gcT	p.A270A	A1BG-AS1_ENST00000594950.1_RNA|A1BG-AS1_ENST00000600379.1_RNA|CTD-2619J13.8_ENST00000599109.1_RNA|A1BG-AS1_ENST00000599728.1_RNA|A1BG-AS1_ENST00000593374.1_RNA|A1BG-AS1_ENST00000593960.1_RNA|A1BG-AS1_ENST00000600686.1_RNA	NM_130786.3	NP_570602.2	P04217	A1BG_HUMAN	alpha-1-B glycoprotein	270	Ig-like V-type 3.					extracellular region				NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|prostate(2)	15		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)		CATCCCCCAGGGCCACCGCGT	0.632000													8	46					0	0	1	0	0
HGFAC	3083	broad.mit.edu	37	4	3446124	3446124	+	Missense_Mutation	SNP	G	G	C	rs138611679		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr4:3446124G>C	ENST00000382774.3	+	6	800	c.685G>C	c.(685-687)Gag>Cag	p.E229Q	HGFAC_ENST00000511533.1_Missense_Mutation_p.E229Q	NM_001528.2	NP_001519.1	Q04756	HGFA_HUMAN	HGF activator	229	Fibronectin type-I.				proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	22				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		GGAACAGTGCGAGTGCTTCGG	0.677000													3	6					0	0	1	0	0
ZNF681	148213	broad.mit.edu	37	19	23927544	23927544	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:23927544T>C	ENST00000402377.3	-	4	949	c.808A>G	c.(808-810)Aca>Gca	p.T270A	ZNF681_ENST00000395385.3_Missense_Mutation_p.T201A	NM_138286.2	NP_612143.2	Q96N22	ZN681_HUMAN	zinc finger protein 681	270					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(3)	21		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				GTATGTGTTGTAATGTGTGAC	0.353000													17	47					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140263756	140263756	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:140263756C>T	ENST00000289272.2	+	1	1903	c.1903C>T	c.(1903-1905)Cgc>Tgc	p.R635C	PCDHA11_ENST00000398640.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA13_ENST00000409494.1_Missense_Mutation_p.R635C	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGCACGACGCGCCCTCTGGA	0.677000													42	50					0	0	1	0	0
TMEM132A	54972	broad.mit.edu	37	11	60695278	60695278	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:60695278C>T	ENST00000005286.4	+	3	634	c.481C>T	c.(481-483)Cgg>Tgg	p.R161W	TMEM132A_ENST00000453848.2_Missense_Mutation_p.R161W	NM_017870.3|NM_178031.2	NP_060340.2|NP_821174.1	Q24JP5	T132A_HUMAN	transmembrane protein 132A	161						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						GCCCTGTGCCCGGCTCCATGC	0.652000													26	45					0	0	1	0	0
CDHR1	92211	broad.mit.edu	37	10	85973956	85973956	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:85973956C>G	ENST00000372117.3	+	17	2262	c.2159C>G	c.(2158-2160)tCc>tGc	p.S720C	CDHR1_ENST00000332904.3_Intron|CDHR1_ENST00000440770.2_Missense_Mutation_p.S424C	NM_033100.2	NP_149091.1	Q96JP9	CDHR1_HUMAN	cadherin-related family member 1	720					homophilic cell adhesion		calcium ion binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(21)|ovary(1)|prostate(1)|skin(1)	36						GTCCTCATCTCCACCGCCACC	0.637000													18	59					0	0	1	0	0
LAMB1	3912	broad.mit.edu	37	7	107601691	107601691	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:107601691G>A	ENST00000393561.1	-	15	2325	c.2141C>T	c.(2140-2142)tCt>tTt	p.S714F	LAMB1_ENST00000222399.6_Missense_Mutation_p.S690F|LAMB1_ENST00000393560.1_Missense_Mutation_p.S690F			P07942	LAMB1_HUMAN	laminin, beta 1	690	Laminin IV type B.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTCGCTATCAGAGGAGGTGTA	0.547000													11	51					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53126796	53126796	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:53126796T>C	ENST00000276480.7	-	7	705	c.22A>G	c.(22-24)Aaa>Gaa	p.K8E		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	8						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CGCAGCGTTTTATCTTCAGCC	0.428000													29	47					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57548325	57548325	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:57548325G>T	ENST00000243077.3	+	8	1534	c.1068G>T	c.(1066-1068)caG>caT	p.Q356H	LRP1_ENST00000554174.1_Missense_Mutation_p.Q356H	NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	356					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TGGATGGGCAGAACCGCACCA	0.527000													10	27					2.17888e-05	2.24353e-05	1	1	0
OR10Q1	219960	broad.mit.edu	37	11	57995510	57995510	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:57995510C>T	ENST00000316770.2	-	1	880	c.838G>A	c.(838-840)Gcg>Acg	p.A280T		NM_001004471.2	NP_001004471.1	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q, member 1	280					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A280T(1)		autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)	35		Breast(21;0.0589)				TAGACCAACGCGATTTGGCTG	0.547000													23	118					0	0	1	0	0
SLC15A1	6564	broad.mit.edu	37	13	99337111	99337111	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr13:99337111A>G	ENST00000376503.5	-	23	2049	c.1994T>C	c.(1993-1995)aTc>aCc	p.I665T		NM_005073.3	NP_005064.1	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide transporter), member 1	665					digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	30	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	CCGAGCCATGATGGCAAAAAT	0.413000													6	45					0	0	1	0	0
MALAT1	378938	broad.mit.edu	37	11	65265452	65265452	+	RNA	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:65265452A>G	ENST00000534336.1	+	0	220					NR_002819.2																						AGGTGGTGGTATTTAGATAAA	0.507000													53	70					0	0	1	0	0
GCNT2	2651	broad.mit.edu	37	6	10557396	10557396	+	Missense_Mutation	SNP	C	C	T	rs55683126		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:10557396C>T	ENST00000316170.3	+	1	1157	c.740C>T	c.(739-741)gCg>gTg	p.A247V	GCNT2_ENST00000379597.3_Intron|GCNT2_ENST00000410107.1_Intron|GCNT2_ENST00000397423.2_Intron|GCNT2_ENST00000495262.1_Intron	NM_001491.2	NP_001482.1	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	249						Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)	12	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		AGAACAACAGCGTTGAAACCG	0.507000													8	175					0	0	1	0	0
KBTBD7	84078	broad.mit.edu	37	13	41766515	41766515	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr13:41766515G>A	ENST00000379483.3	-	1	2187	c.1879C>T	c.(1879-1881)Cag>Tag	p.Q627*		NM_032138.4	NP_115514.2	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	627							protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(4)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		ATAAAACTCTGACCAGGTTCA	0.438000													33	74					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10216603	10216603	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:10216603A>T	ENST00000418404.3	-	29	4216	c.4053T>A	c.(4051-4053)taT>taA	p.Y1351*	MYH13_ENST00000252172.4_Nonsense_Mutation_p.Y1351*|RP11-401O9.4_ENST00000609088.1_RNA			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1351					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						GCTCCTCCTCATACTGTTCCC	0.602000													19	80					0	0	1	0	0
MRPL40	64976	broad.mit.edu	37	22	19423455	19423455	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr22:19423455G>C	ENST00000333130.3	+	4	1244	c.591G>C	c.(589-591)aaG>aaC	p.K197N	HIRA_ENST00000541063.1_Intron|HIRA_ENST00000546308.1_Intron|MRPL40_ENST00000443660.1_3'UTR	NM_003776.2	NP_003767.2	Q9NQ50	RM40_HUMAN	mitochondrial ribosomal protein L40	197					anatomical structure morphogenesis	mitochondrial ribosome|nucleus				endometrium(1)|upper_aerodigestive_tract(1)	2	Colorectal(54;0.0993)					ACATCACCAAGGTGTACACAC	0.502000													11	50					0	0	1	0	0
GABPA	2551	broad.mit.edu	37	21	27130395	27130395	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr21:27130395A>G	ENST00000354828.3	+	6	1155	c.628A>G	c.(628-630)Ata>Gta	p.I210V	GABPA_ENST00000400075.3_Missense_Mutation_p.I210V	NM_001197297.1	NP_001184226.1	Q06546	GABPA_HUMAN	GA binding protein transcription factor, alpha subunit 60kDa	210	PNT.				positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(5)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	24						CATGACCGATATAGACCTCAC	0.438000													11	68					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140208233	140208233	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:140208233G>A	ENST00000529310.1	+	1	671	c.557G>A	c.(556-558)aGt>aAt	p.S186N	PCDHA4_ENST00000530339.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Missense_Mutation_p.S186N|PCDHA1_ENST00000394633.3_Intron	NM_018909.2|NM_031848.2|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAAATAAACAGTGATGACAAT	0.443000													34	56					0	0	1	0	0
ERCC3	2071	broad.mit.edu	37	2	128036775	128036775	+	Silent	SNP	T	T	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:128036775T>C	ENST00000493187.2	-	10	1975	c.1512A>G	c.(1510-1512)ctA>ctG	p.L504L	ERCC3_ENST00000285398.2_Silent_p.L568L			P19447	ERCC3_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 3	568					cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	31	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		CATATTCCTTTAGGGCAAACA	0.428000			"""Mis, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				17	22					0	0	1	0	0
PGBD1	84547	broad.mit.edu	37	6	28269137	28269137	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:28269137C>G	ENST00000405948.2	+	7	1926	c.1506C>G	c.(1504-1506)ttC>ttG	p.F502L	PGBD1_ENST00000259883.3_Missense_Mutation_p.F502L	NM_001184743.1|NM_032507.3	NP_001171672.1|NP_115896.1	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	502					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(16)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	41						AATTGATTTTCTCAAACCTGC	0.373000													47	117					0	0	1	0	0
SEPN1	57190	broad.mit.edu	37	1	26140386	26140386	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:26140386C>T	ENST00000361547.2	+	11	1457	c.1402C>T	c.(1402-1404)Ctc>Ttc	p.L468F	SEPN1_ENST00000374315.1_Missense_Mutation_p.L434F|SEPN1_ENST00000354177.4_Missense_Mutation_p.L434F|SEPN1_ENST00000494537.1_3'UTR	NM_020451.2	NP_065184.2	Q9NZV5	SELN_HUMAN	selenoprotein N, 1	468						endoplasmic reticulum membrane|extracellular region	protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0421)|OV - Ovarian serous cystadenocarcinoma(117;1.26e-25)|Colorectal(126;3.01e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0143)|READ - Rectum adenocarcinoma(331;0.0649)		AGGGCGGACTCTCCGGGAGAC	0.602000													11	67					0	0	1	0	0
ZNF486	90649	broad.mit.edu	37	19	20308324	20308324	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:20308324G>A	ENST00000335117.8	+	4	862	c.805G>A	c.(805-807)Gaa>Aaa	p.E269K	CTC-260E6.6_ENST00000585498.1_RNA|CTC-260E6.6_ENST00000593655.1_RNA|CTC-260E6.6_ENST00000586657.1_RNA	NM_052852.3	NP_443084.2	Q96H40	ZN486_HUMAN	zinc finger protein 486	269					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	11						CTACATTTGTGAAGAATGTGG	0.373000													8	35					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139691860	139691860	+	Splice_Site	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:139691860C>T	ENST00000303045.6	-	40	3518	c.3072G>A	c.(3070-3072)aaG>aaA	p.K1024K	COL22A1_ENST00000341807.4_Intron|COL22A1_ENST00000435777.1_Intron	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1024	Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CTTCACTGACCTTAACACATT	0.413000										HNSCC(7;0.00092)			12	70					0	0	1	0	0
SHE	126669	broad.mit.edu	37	1	154471660	154471660	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:154471660G>A	ENST00000304760.2	-	2	732	c.646C>T	c.(646-648)Caa>Taa	p.Q216*		NM_001010846.2	NP_001010846.1	Q5VZ18	SHE_HUMAN	Src homology 2 domain containing E	216										breast(4)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(2)|pancreas(1)	14	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			GCATCCCTTTGACCCTTTGTC	0.453000													26	62					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16990556	16990556	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:16990556G>A	ENST00000377833.4	-	35	5195	c.5130C>T	c.(5128-5130)agC>agT	p.S1710S		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	1710	CUB 11.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GCGTCAGGGCGCTGCTGAAGG	0.512000													15	25					0	0	1	0	0
CCDC146	57639	broad.mit.edu	37	7	76908345	76908345	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:76908345G>A	ENST00000285871.4	+	13	1748	c.1621G>A	c.(1621-1623)Gaa>Aaa	p.E541K	CCDC146_ENST00000415740.2_3'UTR|CCDC146_ENST00000431197.1_Missense_Mutation_p.E255K	NM_020879.2	NP_065930.2	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	541										breast(3)|central_nervous_system(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	34		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				GAAAGTAAATGAAATAAAAGA	0.308000													7	51					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58088057	58088057	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:58088057G>A	ENST00000357272.4	+	9	1638	c.1473G>A	c.(1471-1473)atG>atA	p.M491I	FLNB_ENST00000419752.2_Missense_Mutation_p.M322I|FLNB_ENST00000348383.5_Missense_Mutation_p.M491I|FLNB_ENST00000358537.3_Missense_Mutation_p.M491I|FLNB_ENST00000490882.1_Missense_Mutation_p.M491I|FLNB_ENST00000493452.1_Missense_Mutation_p.M322I|FLNB_ENST00000295956.4_Missense_Mutation_p.M491I|FLNB_ENST00000429972.2_Missense_Mutation_p.M491I			O75369	FLNB_HUMAN	filamin B, beta	491					actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GTGTAACCATGAAGGGTCCTA	0.522000													35	47					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152080442	152080442	+	Missense_Mutation	SNP	C	C	G	rs71585886		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:152080442C>G	ENST00000368804.1	-	2	5250	c.5251G>C	c.(5251-5253)Gag>Cag	p.E1751Q		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1751	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding	p.E1751K(1)		NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCTCTTCCTCTAGGATTTTT	0.592000													23	69					0	0	1	0	0
LGR4	55366	broad.mit.edu	37	11	27405924	27405924	+	Silent	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:27405924C>G	ENST00000379214.4	-	6	1091	c.648G>C	c.(646-648)ctG>ctC	p.L216L	LGR4_ENST00000389858.4_Silent_p.L192L	NM_018490.2	NP_060960.2	Q9BXB1	LGR4_HUMAN	leucine-rich repeat containing G protein-coupled receptor 4	216						integral to membrane|plasma membrane	protein-hormone receptor activity			NS(3)|breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(10)|ovary(1)	32						AGTGTTGACTCAGGCTTCTAA	0.323000													32	42					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31591514	31591514	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:31591514C>T	ENST00000379416.3	-	19	2041	c.1993G>A	c.(1993-1995)Ggg>Agg	p.G665R		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	665					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	ATGATATGCCCAACACAAGTA	0.443000													26	66					0	0	1	0	0
CDC16	8881	broad.mit.edu	37	13	115037904	115037904	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr13:115037904G>C	ENST00000360383.3	+	18	2047	c.1849G>C	c.(1849-1851)Gac>Cac	p.D617H	CDC16_ENST00000375308.1_Missense_Mutation_p.D523H|CDC16_ENST00000375312.3_Missense_Mutation_p.D472H|CDC16_ENST00000252457.5_Missense_Mutation_p.D616H|CDC16_ENST00000375310.1_Missense_Mutation_p.D523H|CDC16_ENST00000356221.3_Missense_Mutation_p.D617H|CDC16_ENST00000252458.6_Missense_Mutation_p.D472H|CDC16_ENST00000461716.1_3'UTR	NM_001078645.1|NM_003903.3	NP_001072113.1|NP_003894.3	Q13042	CDC16_HUMAN	cell division cycle 16	617					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cell proliferation|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	binding			endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)			ATCTATGTCAGACCACAGCAC	0.453000													36	17					0	0	1	0	0
PGBD1	84547	broad.mit.edu	37	6	28269477	28269477	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:28269477G>A	ENST00000405948.2	+	7	2266	c.1846G>A	c.(1846-1848)Gag>Aag	p.E616K	PGBD1_ENST00000259883.3_Missense_Mutation_p.E616K	NM_001184743.1|NM_032507.3	NP_001171672.1|NP_115896.1	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	616					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(16)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	41						TGTTCTTTTAGAGAGAGGTCA	0.418000													50	115					0	0	1	0	0
GPATCH8	23131	broad.mit.edu	37	17	42476849	42476849	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:42476849A>T	ENST00000434000.1	-	9	2644	c.2362T>A	c.(2362-2364)Tcc>Acc	p.S788T	GPATCH8_ENST00000591680.1_Missense_Mutation_p.S866T			Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	866						intracellular	nucleic acid binding|zinc ion binding			breast(4)|endometrium(7)|kidney(6)|large_intestine(4)|liver(2)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		GAACGCCGGGAGGAACGATGC	0.537000													35	93					0	0	1	0	0
SCAPER	49855	broad.mit.edu	37	15	76995205	76995205	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr15:76995205G>C	ENST00000538941.2	-	19	2587	c.1648C>G	c.(1648-1650)Ctc>Gtc	p.L550V	SCAPER_ENST00000324767.7_Missense_Mutation_p.L796V|SCAPER_ENST00000563290.1_Missense_Mutation_p.L796V	NM_001145923.1	NP_001139395.1	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	795	Glu-rich.			HEEKQ -> KKKKK (in Ref. 3; AAI07416).		endoplasmic reticulum|nucleus	zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(16)|ovary(2)|prostate(2)|skin(1)|urinary_tract(2)	39						ACATTGCAGAGAGAACACTGC	0.358000													17	70					0	0	1	0	0
PCDHB12	56124	broad.mit.edu	37	5	140589944	140589944	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:140589944T>A	ENST00000239450.2	+	1	1654	c.1465T>A	c.(1465-1467)Tcg>Acg	p.S489T	PCDHB12_ENST00000541609.1_Missense_Mutation_p.S152T	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		489	Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTCAACTACTCGCTGCTGCC	0.657000													16	102					0	0	1	0	0
NFATC2	4773	broad.mit.edu	37	20	50139915	50139915	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr20:50139915C>T	ENST00000371564.3	-	2	1084	c.865G>A	c.(865-867)Ggc>Agc	p.G289S	NFATC2_ENST00000414705.1_Missense_Mutation_p.G269S|NFATC2_ENST00000609943.1_Missense_Mutation_p.G269S|NFATC2_ENST00000610033.1_Missense_Mutation_p.G70S|NFATC2_ENST00000396009.3_Missense_Mutation_p.G289S|NFATC2_ENST00000609507.1_Missense_Mutation_p.G70S	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	289					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					GCCGGGGAGCCGTGGTCCTGG	0.711000													4	14					0	0	1	0	0
FGF13	2258	broad.mit.edu	37	X	137790983	137790983	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chrX:137790983A>T	ENST00000315930.6	-	2	956	c.295T>A	c.(295-297)Tac>Aac	p.Y99N	FGF13_ENST00000370603.3_Missense_Mutation_p.Y109N|FGF13_ENST00000305414.4_Missense_Mutation_p.Y46N|FGF13_ENST00000441825.2_Missense_Mutation_p.Y80N|FGF13_ENST00000541469.1_Missense_Mutation_p.Y53N	NM_004114.3	NP_004105.1	Q92913	FGF13_HUMAN	fibroblast growth factor 13	99					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)	24	Acute lymphoblastic leukemia(192;0.000127)					CACTTACTGTAAGTGCTGTCC	0.383000													31	50					0	0	1	0	0
LOC643733	643733	broad.mit.edu	37	11	104776315	104776315	+	RNA	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:104776315C>T	ENST00000532510.1	-	0	3117																											ATGCCTTGGGCTATGACCTTC	0.383000													13	14					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38743576	38743576	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:38743576C>G	ENST00000449082.2	-	26	4410	c.4411G>C	c.(4411-4413)Gac>Cac	p.D1471H		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1471					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GTCACGATGTCAAAGACAAAA	0.458000													17	80					0	0	1	0	0
CLASP2	23122	broad.mit.edu	37	3	33626305	33626305	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:33626305T>C	ENST00000399362.4	-	22	2529	c.2176A>G	c.(2176-2178)Aga>Gga	p.R726G	CLASP2_ENST00000539981.1_Missense_Mutation_p.R496G|CLASP2_ENST00000480013.1_Missense_Mutation_p.R493G|CLASP2_ENST00000307312.7_Missense_Mutation_p.R215G|CLASP2_ENST00000359576.5_Missense_Mutation_p.R726G|CLASP2_ENST00000468888.2_Missense_Mutation_p.R727G|CLASP2_ENST00000461133.3_Missense_Mutation_p.R493G	NM_015097.2	NP_055912.2	B2RTR1	B2RTR1_HUMAN	cytoplasmic linker associated protein 2	727										breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	48						ATCTTGCTTCTTTTTTGTGCT	0.473000													31	38					0	0	1	0	0
WNK3	65267	broad.mit.edu	37	X	54265480	54265480	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chrX:54265480G>A	ENST00000354646.2	-	18	4142	c.3704C>T	c.(3703-3705)gCt>gTt	p.A1235V	WNK3_ENST00000375159.2_Missense_Mutation_p.A1235V|WNK3_ENST00000375169.3_Missense_Mutation_p.A1235V	NM_020922.4	NP_065973.2	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3	1235					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			autonomic_ganglia(1)|biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(24)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80						GCTTGACACAGCAGCAGGATA	0.428000													3	17					0	0	1	0	0
LPCAT1	79888	broad.mit.edu	37	5	1479749	1479749	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:1479749T>A	ENST00000283415.3	-	8	935	c.803A>T	c.(802-804)cAa>cTa	p.Q268L		NM_024830.3	NP_079106.3	Q8NF37	PCAT1_HUMAN	lysophosphatidylcholine acyltransferase 1	268					phospholipid biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		GATTTCCACTTGGTTGTGAAA	0.448000											OREG0016481	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	26					0	0	1	0	0
KCNA4	3739	broad.mit.edu	37	11	30032651	30032651	+	Silent	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:30032651C>G	ENST00000328224.6	-	2	2808	c.1575G>C	c.(1573-1575)gtG>gtC	p.V525V		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	525						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						CCCCATAGCCCACAGTTGTCA	0.517000													14	40					0	0	1	0	0
MCHR1	2847	broad.mit.edu	37	22	41077323	41077323	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr22:41077323C>T	ENST00000249016.4	+	2	1356	c.660C>T	c.(658-660)tcC>tcT	p.S220S	MCHR1_ENST00000498400.1_3'UTR|MCHR1_ENST00000381433.2_Intron	NM_005297.3	NP_005288.3	Q99705	MCHR1_HUMAN	melanin-concentrating hormone receptor 1	220					elevation of cytosolic calcium ion concentration|feeding behavior|generation of precursor metabolites and energy|inhibition of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane|nonmotile primary cilium	neuropeptide receptor activity			endometrium(5)|large_intestine(7)|lung(6)|pancreas(1)|urinary_tract(1)	20						CCATCTCTTCCACGAAGTTCC	0.587000													26	51					0	0	1	0	0
CABP4	57010	broad.mit.edu	37	11	67222934	67222934	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:67222934C>G	ENST00000325656.5	+	1	117	c.40C>G	c.(40-42)Ctg>Gtg	p.L14V	CABP4_ENST00000542025.2_3'UTR|CABP4_ENST00000438189.2_Intron	NM_145200.3	NP_660201.1	P57796	CABP4_HUMAN	calcium binding protein 4	14					visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding			central_nervous_system(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(2)	11			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			GGGCCCAAATCTGGCCATTGG	0.632000													5	5					0	0	1	0	0
CD244	51744	broad.mit.edu	37	1	160808273	160808273	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:160808273C>G	ENST00000368034.4	-	5	979	c.802G>C	c.(802-804)Gat>Cat	p.D268H	CD244_ENST00000368033.3_Missense_Mutation_p.D273H|CD244_ENST00000322302.7_Missense_Mutation_p.D176H|CD244_ENST00000481677.1_5'UTR|CD244_ENST00000368032.2_Missense_Mutation_p.D268H	NM_001166663.1|NM_001166664.1|NM_016382.3	NP_001160135.1|NP_001160136.1|NP_057466.1	Q9BZW8	CD244_HUMAN	CD244 molecule, natural killer cell receptor 2B4	273					blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|large_intestine(3)|lung(12)|ovary(1)|urinary_tract(1)	18	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			TCCTTGACATCTTCGTAAATT	0.453000													140	80					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151902229	151902229	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:151902229G>C	ENST00000355193.2	-	25	4141	c.3923C>G	c.(3922-3924)tCa>tGa	p.S1308*	KMT2C_ENST00000262189.6_Nonsense_Mutation_p.S1308*					lysine (K)-specific methyltransferase 2C																		AATAGAGCCTGAGGAATCTTT	0.358000													5	25					0	0	1	0	0
PSD	5662	broad.mit.edu	37	10	104174879	104174879	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:104174879C>T	ENST00000020673.5	-	4	1391	c.865G>A	c.(865-867)Gac>Aac	p.D289N	PSD_ENST00000406432.1_Missense_Mutation_p.D289N	NM_001270966.1|NM_002779.4	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	289					regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|endometrium(2)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		GGCACCGTGTCCAGGTCTGTC	0.672000													8	43					0	0	1	0	0
MYO19	80179	broad.mit.edu	37	17	34864917	34864917	+	Silent	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:34864917C>A	ENST00000431794.3	-	14	1737	c.1215G>T	c.(1213-1215)tcG>tcT	p.S405S	MYO19_ENST00000268852.9_Silent_p.S405S	NM_001163735.1	NP_001157207.1	Q96H55	MYO19_HUMAN	myosin XIX	405	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|urinary_tract(1)	20		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		AAGTGGTCCACGAGTCGGTGT	0.547000													12	17					9.05144e-12	1.00027e-11	1	1	0
MIRLET7E	406887	broad.mit.edu	37	19	52196182	52196182	+	RNA	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:52196182A>G	ENST00000602324.1	-	0	527					NR_029482.1|NR_029693.1																						CCTTAGCCCCACTGGGCTGCC	0.652000													11	15					0	0	1	0	0
MATN2	4147	broad.mit.edu	37	8	98943551	98943551	+	Silent	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:98943551G>C	ENST00000254898.5	+	3	744	c.513G>C	c.(511-513)ggG>ggC	p.G171G	MATN2_ENST00000520016.1_Silent_p.G171G|MATN2_ENST00000521689.1_Silent_p.G171G|MATN2_ENST00000524308.1_Silent_p.G171G|MATN2_ENST00000522025.2_Intron	NM_002380.3|NM_030583.2	NP_002371.3|NP_085072.2	O00339	MATN2_HUMAN	matrilin 2	171	VWFA 1.					proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(17)|ovary(2)|urinary_tract(1)	31	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			TGACAGATGGGAGACCTCAGG	0.582000													7	31					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176564283	176564283	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:176564283G>T	ENST00000367662.3	+	3	2707	c.1543G>T	c.(1543-1545)Gga>Tga	p.G515*	PAPPA2_ENST00000367661.3_Nonsense_Mutation_p.G515*	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	515	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CCAGTACAATGGATACTGGCC	0.537000													13	118					5.50884e-06	5.72325e-06	1	1	0
ROPN1L	83853	broad.mit.edu	37	5	10461368	10461368	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:10461368C>T	ENST00000503804.1	+	5	1011	c.490C>T	c.(490-492)Ccc>Tcc	p.P164S	ROPN1L_ENST00000274134.4_Missense_Mutation_p.P164S|ROPN1L_ENST00000510520.1_3'UTR			Q96C74	ROP1L_HUMAN	rhophilin associated tail protein 1-like	164					ciliary or flagellar motility|signal transduction	cytoplasm|motile cilium	cAMP-dependent protein kinase regulator activity|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)	14						CGCTCGCATCCCCTTCAAGAC	0.567000													18	105					0	0	1	0	0
TRUB1	142940	broad.mit.edu	37	10	116732026	116732026	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:116732026C>T	ENST00000298746.3	+	6	790	c.729C>T	c.(727-729)ttC>ttT	p.F243F		NM_139169.4	NP_631908.1	Q8WWH5	TRUB1_HUMAN	TruB pseudouridine (psi) synthase family member 1	243					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(2)|kidney(2)|large_intestine(1)|lung(5)|urinary_tract(2)	12		Colorectal(252;0.09)|Breast(234;0.174)|Lung NSC(174;0.245)		Epithelial(162;0.00879)|all cancers(201;0.0243)		CACCATTTTTCACATTAGGTA	0.358000													30	52					0	0	1	0	0
RNF180	285671	broad.mit.edu	37	5	63509826	63509826	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:63509826C>A	ENST00000389100.4	+	4	745	c.673C>A	c.(673-675)Cat>Aat	p.H225N	RNF180_ENST00000296615.6_Missense_Mutation_p.H225N|RNF180_ENST00000381081.2_Intron	NM_001113561.1	NP_001107033.1	Q86T96	RN180_HUMAN	ring finger protein 180	225						integral to membrane|nuclear envelope	zinc ion binding			breast(1)|kidney(1)|large_intestine(4)|lung(9)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	20		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0848)|Colorectal(97;0.234)		Lung(70;0.114)		AAGAGCTTTTCATAGAAAATC	0.388000													31	46					1.08312e-15	1.20462e-15	1	1	0
MXD1	4084	broad.mit.edu	37	2	70164512	70164512	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:70164512C>G	ENST00000264444.2	+	5	724	c.464C>G	c.(463-465)tCc>tGc	p.S155C	MXD1_ENST00000540449.1_Missense_Mutation_p.S145C	NM_001202513.1|NM_001202514.1|NM_002357.3	NP_001189442.1|NP_001189443.1|NP_002348.1	Q05195	MAD1_HUMAN	MAX dimerization protein 1	155					cell proliferation|multicellular organismal development	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(1)|upper_aerodigestive_tract(1)	7						TCGGAGCGCTCCGACTCCGAC	0.627000													19	42					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79441572	79441572	+	Silent	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:79441572C>G	ENST00000376718.3	-	5	708	c.585G>C	c.(583-585)ctG>ctC	p.L195L	PRUNE2_ENST00000376713.3_Silent_p.L195L|PRUNE2_ENST00000428286.1_5'UTR	NM_015225.2	NP_056040.2	Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	195					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						ATTTTTCTTCCAGGATAGAAA	0.443000													16	88					0	0	1	0	0
ZMYM1	79830	broad.mit.edu	37	1	35580244	35580244	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:35580244G>C	ENST00000373330.1	+	11	2987	c.2813G>C	c.(2812-2814)aGa>aCa	p.R938T	ZMYM1_ENST00000359858.4_Missense_Mutation_p.R938T|ZMYM1_ENST00000373329.1_3'UTR			Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM-type 1	938						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(5)|lung(8)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CTTCAGAAAAGAAGAAAAATT	0.284000													4	54					0	0	1	0	0
DPP6	1804	broad.mit.edu	37	7	154659794	154659794	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:154659794G>T	ENST00000404039.1	+	18	2199	c.1612G>T	c.(1612-1614)Gat>Tat	p.D538Y	DPP6_ENST00000377770.3_Missense_Mutation_p.D602Y|DPP6_ENST00000332007.3_Missense_Mutation_p.D540Y|DPP6_ENST00000427557.1_Missense_Mutation_p.D495Y	NM_001039350.1|NM_001936.3|NM_130797.2	NP_001034439.1|NP_001927.3|NP_570629.2	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	602					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			CATTGAGATTGATGATTACAG	0.413000													4	12					0.00909568	0.009175	1	1	0
UBASH3A	53347	broad.mit.edu	37	21	43836631	43836631	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr21:43836631G>C	ENST00000319294.6	+	6	779	c.748G>C	c.(748-750)Gag>Cag	p.E250Q	UBASH3A_ENST00000291535.6_Missense_Mutation_p.E212Q|UBASH3A_ENST00000398367.1_Missense_Mutation_p.E212Q	NM_018961.3	NP_061834.1	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing A	250						cytosol|nucleus				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(9)|lung(12)|ovary(3)	28						GAGGACGCTGGAGCAGCTGGC	0.597000													16	21					0	0	1	0	0
SIDT2	51092	broad.mit.edu	37	11	117063363	117063363	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:117063363C>T	ENST00000324225.4	+	21	2586	c.2055C>T	c.(2053-2055)taC>taT	p.Y685Y	SIDT2_ENST00000532062.1_5'UTR|SIDT2_ENST00000431081.2_Silent_p.Y682Y	NM_001040455.1	NP_001035545.1	Q8NBJ9	SIDT2_HUMAN	SID1 transmembrane family, member 2	685						integral to membrane|lysosomal membrane				NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	36	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000219)|all cancers(92;0.00144)		GGCCGCTCTACGTGGTACCTG	0.632000													11	26					0	0	1	0	0
HIST2H2AB	317772	broad.mit.edu	37	1	149859361	149859361	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:149859361G>C	ENST00000331128.3	-	1	105	c.106C>G	c.(106-108)Cgc>Ggc	p.R36G		NM_175065.2	NP_778235.1	Q8IUE6	H2A2B_HUMAN	histone cluster 2, H2ab	36					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	15	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			TTGCCTTTGCGCAGCAAGCGG	0.697000													20	99					0	0	1	0	0
ZIC1	7545	broad.mit.edu	37	3	147128322	147128322	+	Silent	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:147128322C>G	ENST00000282928.4	+	1	1152	c.423C>G	c.(421-423)ctC>ctG	p.L141L		NM_003412.3	NP_003403.2	Q15915	ZIC1_HUMAN	Zic family member 1	141					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(4)|cervix(1)|endometrium(2)|large_intestine(8)|lung(38)|ovary(1)|prostate(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	63						CGGGCCACCTCCTCTTCCCCG	0.726000													3	18					0	0	1	0	0
KDM5B	10765	broad.mit.edu	37	1	202702685	202702685	+	Silent	SNP	T	T	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:202702685T>A	ENST00000367265.3	-	23	4917	c.3753A>T	c.(3751-3753)gcA>gcT	p.A1251A	KDM5B_ENST00000367264.2_Silent_p.A1287A	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	1251					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						TATATCGAAGTGCATCTCCCT	0.512000													14	57					0	0	1	0	0
OR4M2	390538	broad.mit.edu	37	15	22368693	22368693	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr15:22368693C>A	ENST00000332663.2	+	1	216	c.118C>A	c.(118-120)Cca>Aca	p.P40T	RP11-69H14.6_ENST00000558896.1_RNA	NM_001004719.2	NP_001004719.2	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M, member 2	40					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(38)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	63		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		GTTCATCCTACCAGGAAATAT	0.418000													44	389					1.62957e-23	1.84189e-23	1	1	0
MGAT4A	11320	broad.mit.edu	37	2	99294780	99294780	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:99294780C>G	ENST00000264968.3	-	2	612	c.249G>C	c.(247-249)ttG>ttC	p.L83F	MGAT4A_ENST00000409391.1_Missense_Mutation_p.L83F|MGAT4A_ENST00000393487.1_Missense_Mutation_p.L83F			Q9UM21	MGT4A_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A						N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|stomach(1)	19						AAAACTTATTCAACGCATCCT	0.294000													17	108					0	0	1	0	0
RASSF9	9182	broad.mit.edu	37	12	86199049	86199049	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:86199049G>T	ENST00000361228.3	-	2	1107	c.739C>A	c.(739-741)Cta>Ata	p.L247I		NM_005447.3	NP_005438.2	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family (N-terminal) member 9	247					endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TGCAAGTCTAGATTTTGCTCA	0.403000													19	85					1.01871e-10	1.11512e-10	1	1	0
CSTF2T	23283	broad.mit.edu	37	10	53457995	53457995	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:53457995C>G	ENST00000331173.4	-	1	1360	c.1315G>C	c.(1315-1317)Gag>Cag	p.E439Q	PRKG1_ENST00000373980.4_Intron|PRKG1_ENST00000401604.2_Intron|PRKG1_ENST00000373985.1_Intron	NM_015235.2	NP_056050.1	Q9H0L4	CSTFT_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant	439	9 X 5 AA tandem repeats of M-E-T-R-[AG].|Gly-rich.				mRNA processing	nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	30				COAD - Colon adenocarcinoma(2;0.00736)|Colorectal(2;0.00898)|all cancers(4;0.0188)|GBM - Glioblastoma multiforme(4;0.0778)|Epithelial(53;0.122)		GCACAGGTCTCCATTCCTCTC	0.537000													19	66					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38743492	38743492	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:38743492C>G	ENST00000449082.2	-	26	4494	c.4495G>C	c.(4495-4497)Gac>Cac	p.D1499H		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1499					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TCACTTTGGTCATCAGTCTCC	0.458000													31	89					0	0	1	0	0
ZC3HC1	51530	broad.mit.edu	37	7	129688905	129688905	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:129688905C>G	ENST00000358303.4	-	2	310	c.226G>C	c.(226-228)Gaa>Caa	p.E76Q	ZC3HC1_ENST00000311873.5_Missense_Mutation_p.E55Q|ZC3HC1_ENST00000360708.5_Missense_Mutation_p.E76Q|ZC3HC1_ENST00000481503.1_Missense_Mutation_p.E76Q	NM_016478.3	NP_057562.3	Q86WB0	NIPA_HUMAN	zinc finger, C3HC-type containing 1	76					cell division|mitosis	nucleus	protein kinase binding|zinc ion binding			endometrium(2)|kidney(6)|large_intestine(10)|lung(2)|prostate(1)|urinary_tract(1)	22	Melanoma(18;0.0435)					AAGAAGGCTTCTTTGCTTGTA	0.408000													32	61					0	0	1	0	0
CGN	57530	broad.mit.edu	37	1	151491799	151491799	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:151491799G>A	ENST00000271636.7	+	2	937	c.804G>A	c.(802-804)caG>caA	p.Q268Q		NM_020770.2	NP_065821.1	Q9P2M7	CING_HUMAN	cingulin	262	Head.|Interacts with ZO-2.					myosin complex|tight junction	actin binding|motor activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GTTCTCGTCAGACTCAGGACT	0.567000													13	31					0	0	1	0	0
DEK	7913	broad.mit.edu	37	6	18256002	18256002	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:18256002C>G	ENST00000397239.3	-	6	980	c.533G>C	c.(532-534)aGg>aCg	p.R178T	DEK_ENST00000244776.7_Missense_Mutation_p.R144T	NM_003472.3	NP_003463.1	P35659	DEK_HUMAN	DEK oncogene	178	SAP.				chromatin modification|regulation of transcription from RNA polymerase II promoter|signal transduction|transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|histone binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	7	Ovarian(93;0.00769)|Breast(50;0.0495)	all_hematologic(90;0.053)	OV - Ovarian serous cystadenocarcinoma(7;0.00291)|all cancers(50;0.031)|Epithelial(50;0.0332)			ATTCAAGATCCTCTTCACTAG	0.333000			T	NUP214	AML								14	231					0	0	1	0	0
TRAF6	7189	broad.mit.edu	37	11	36512195	36512195	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:36512195C>T	ENST00000526995.1	-	7	1008	c.762G>A	c.(760-762)caG>caA	p.Q254Q	TRAF6_ENST00000348124.5_Silent_p.Q254Q|TRAF6_ENST00000529150.1_5'UTR	NM_004620.3	NP_004611.1	Q9Y4K3	TRAF6_HUMAN	TNF receptor-associated factor 6, E3 ubiquitin protein ligase	254	Interaction with TAX1BP1.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|ossification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell cytokine production|protein autoubiquitination|protein K63-linked ubiquitination|response to interleukin-1|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cell cortex|cytosol|endosome membrane|internal side of plasma membrane|nuclear membrane	histone deacetylase binding|mitogen-activated protein kinase kinase kinase binding|protein kinase B binding|protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(13)|ovary(2)|pancreas(1)	27	all_lung(20;0.211)	all_hematologic(20;0.107)				AGTGATTCCTCTGCATCTAAA	0.473000													28	57					0	0	1	0	0
RIPK1	8737	broad.mit.edu	37	6	3077181	3077181	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:3077181A>G	ENST00000259808.4	+	2	422	c.124A>G	c.(124-126)Atg>Gtg	p.M42V	RIPK1_ENST00000380409.2_Missense_Mutation_p.M42V|RIPK1_ENST00000479389.1_Intron|RIPK1_ENST00000541791.1_Missense_Mutation_p.M42V			Q13546	RIPK1_HUMAN	receptor (TNFRSF)-interacting serine-threonine kinase 1	42	Protein kinase.				activation of caspase activity|activation of JUN kinase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of necroptosis by extracellular signals|innate immune response|MyD88-independent toll-like receptor signaling pathway|positive regulation of anti-apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|protein autophosphorylation|regulation of ATP:ADP antiporter activity|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|death-inducing signaling complex|endosome membrane|mitochondrion|receptor complex	ATP binding|death domain binding|death receptor binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	23	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				CCAGGGACTCATGATCATGAA	0.527000													17	33					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6679429	6679429	+	Missense_Mutation	SNP	C	C	T	rs142868256		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:6679429C>T	ENST00000245907.6	-	37	4627	c.4535G>A	c.(4534-4536)cGc>cAc	p.R1512H	C3_ENST00000599668.1_5'UTR	NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	1512					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CTCAGCACAGCGGCACAGTTC	0.572000													38	77					0	0	1	0	0
GRM1	2911	broad.mit.edu	37	6	146673612	146673612	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:146673612G>C	ENST00000392299.2	+	5	1883	c.1413G>C	c.(1411-1413)gaG>gaC	p.E471D	GRM1_ENST00000361719.2_Missense_Mutation_p.E471D|GRM1_ENST00000355289.4_Missense_Mutation_p.E471D|GRM1_ENST00000492807.2_Missense_Mutation_p.E471D|GRM1_ENST00000282753.1_Missense_Mutation_p.E471D|GRM1_ENST00000507907.1_Missense_Mutation_p.E471D			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	471					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GGTTTGATGAGAAAGGAGACG	0.493000													54	110					0	0	1	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20890060	20890060	+	Missense_Mutation	SNP	C	C	A	rs148373790		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:20890060C>A	ENST00000381552.1	+	11	1770	c.1402C>A	c.(1402-1404)Cat>Aat	p.H468N	SLCO1C1_ENST00000545604.1_Missense_Mutation_p.H468N|SLCO1C1_ENST00000540354.1_Missense_Mutation_p.H419N|SLCO1C1_ENST00000266509.2_Missense_Mutation_p.H468N|SLCO1C1_ENST00000545102.1_Missense_Mutation_p.H350N			Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1	468					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity	p.H468Y(1)		NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					TGTCTCTTATCATGAACGAGC	0.358000													4	27					1	1	1	1	0
PNLIP	5406	broad.mit.edu	37	10	118306905	118306905	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:118306905A>G	ENST00000369221.2	+	3	174	c.146A>G	c.(145-147)aAa>aGa	p.K49R	PNLIP_ENST00000470562.1_3'UTR	NM_000936.2	NP_000927.1	P16233	LIPP_HUMAN	pancreatic lipase	49					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	43				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	TGGTCTCCAAAAGATGTCAAC	0.443000													11	65					0	0	1	0	0
LEPR	3953	broad.mit.edu	37	1	66083712	66083712	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:66083712C>G	ENST00000349533.6	+	16	2463	c.2278C>G	c.(2278-2280)Cta>Gta	p.L760V	LEPR_ENST00000371059.3_Missense_Mutation_p.L760V|LEPR_ENST00000406510.3_Intron|LEPR_ENST00000371060.3_Missense_Mutation_p.L760V|LEPR_ENST00000344610.8_Missense_Mutation_p.L760V|LEPR_ENST00000371058.1_Missense_Mutation_p.L760V	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	760	Fibronectin type-III 4.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TTCCTGGATACTATCACCCAG	0.318000													13	55					0	0	1	0	0
GK2	2712	broad.mit.edu	37	4	80328580	80328580	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr4:80328580C>T	ENST00000358842.3	-	1	792	c.775G>A	c.(775-777)Gac>Aac	p.D259N		NM_033214.2	NP_149991.2	Q14410	GLPK2_HUMAN	glycerol kinase 2	259					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			autonomic_ganglia(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	39						GCACATTGGTCCCCCAAACAC	0.458000													29	68					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176659424	176659424	+	Silent	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:176659424A>G	ENST00000367662.3	+	5	3453	c.2289A>G	c.(2287-2289)ccA>ccG	p.P763P	PAPPA2_ENST00000367661.3_Silent_p.P763P	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	763					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						AGACAGTGCCATCCATGGAAA	0.552000													19	339					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152080319	152080319	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:152080319C>G	ENST00000368804.1	-	2	5373	c.5374G>C	c.(5374-5376)Gag>Cag	p.E1792Q		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1792	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGTCAGACTCTTGGCTGCGC	0.602000													25	75					0	0	1	0	0
GDF5OS	554250	broad.mit.edu	37	20	34022096	34022096	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr20:34022096G>A	ENST00000374375.1	+	2	582	c.140G>A	c.(139-141)aGg>aAg	p.R47K	GDF5_ENST00000374369.3_Silent_p.L373L|GDF5_ENST00000374372.1_Silent_p.L373L																cervix(1)|endometrium(4)|lung(4)	9						TGGCTGAACAGGTACTCATAC	0.597000													57	114					0	0	1	0	0
OR11H4	390442	broad.mit.edu	37	14	20711554	20711554	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr14:20711554G>T	ENST00000315409.2	+	1	657	c.604G>T	c.(604-606)Gct>Tct	p.A202S		NM_001004479.1	NP_001004479.1	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H, member 4	202					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	29	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		CTGTGCCCCAGCTCCCATAAC	0.433000													66	98					2.01871e-26	2.28919e-26	1	1	0
AC005609.1	0	broad.mit.edu	37	5	140242768	140242768	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:140242768C>G	ENST00000502505.1	-	1	456	c.208G>C	c.(208-210)Gtg>Ctg	p.V70L	PCDHA9_ENST00000532602.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA14_ENST00000562220.1_RNA|PCDHA1_ENST00000394633.3_Intron|PCDHA7_ENST00000525929.1_Intron																							GCCACCGTCACCGTGGTGGCG	0.677000													10	25					0	0	1	0	0
C2CD5	9847	broad.mit.edu	37	12	22646159	22646159	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:22646159G>C	ENST00000333957.4	-	11	1515	c.1260C>G	c.(1258-1260)atC>atG	p.I420M	C2CD5_ENST00000396028.2_Missense_Mutation_p.I411M|C2CD5_ENST00000542676.1_Missense_Mutation_p.I420M|C2CD5_ENST00000536386.1_Missense_Mutation_p.I422M|C2CD5_ENST00000446597.1_Missense_Mutation_p.I420M|C2CD5_ENST00000545552.1_Missense_Mutation_p.I433M|C2CD5_ENST00000544930.1_Missense_Mutation_p.I235M	NM_014802.1	NP_055617.1			C2 calcium-dependent domain containing 5																		TCATTTACCAGATGCTAGTTG	0.383000													17	92					0	0	1	0	0
HAS1	3036	broad.mit.edu	37	19	52220265	52220265	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:52220265C>T	ENST00000540069.2	-	3	941	c.881G>A	c.(880-882)tGt>tAt	p.C294Y	HAS1_ENST00000222115.1_Missense_Mutation_p.C295Y|HAS1_ENST00000594621.1_Missense_Mutation_p.C149Y|HAS1_ENST00000601714.1_Missense_Mutation_p.C302Y			Q92839	HAS1_HUMAN	hyaluronan synthase 1	295					cell adhesion	integral to plasma membrane	hyaluronan synthase activity|protein binding			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	40		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00102)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		GTAGCTCTGACAAGCCCGCTC	0.577000													53	159					0	0	1	0	0
OGN	4969	broad.mit.edu	37	9	95152326	95152326	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:95152326C>G	ENST00000262551.4	-	5	860	c.440G>C	c.(439-441)aGa>aCa	p.R147T	OGN_ENST00000468743.1_5'UTR|CENPP_ENST00000375587.3_Intron|OGN_ENST00000375561.5_Missense_Mutation_p.R147T	NM_033014.2	NP_148935.1	P20774	MIME_HUMAN	osteoglycin	147						extracellular space|proteinaceous extracellular matrix	growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|prostate(1)|urinary_tract(1)	13						AAAATCGAGTCTTCTTAAGTT	0.294000													13	33					0	0	1	0	0
ZNF229	7772	broad.mit.edu	37	19	44933335	44933335	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:44933335C>T	ENST00000291187.4	-	6	1925	c.1603G>A	c.(1603-1605)Gga>Aga	p.G535R	ZNF229_ENST00000588931.1_Missense_Mutation_p.G541R|ZNF229_ENST00000591289.1_Intron|CTC-512J12.4_ENST00000588655.1_RNA	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	541					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.G541*(1)		breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				GGTTTCTCTCCTGTGTGCAGT	0.512000													145	87					0	0	1	0	0
IGKV1D-16	28901	broad.mit.edu	37	2	90139389	90139389	+	RNA	SNP	T	T	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:90139389T>C	ENST00000492446.1	+	0	187																											TATTAGCAGCTGGTTAGCCTG	0.527000													53	169					0	0	1	0	0
RPUSD4	84881	broad.mit.edu	37	11	126081382	126081382	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:126081382C>T	ENST00000298317.4	-	1	205	c.152G>A	c.(151-153)cGa>cAa	p.R51Q	RPUSD4_ENST00000533628.1_Missense_Mutation_p.R51Q|FAM118B_ENST00000533050.1_5'UTR	NM_032795.2	NP_116184.2	Q96CM3	RUSD4_HUMAN	RNA pseudouridylate synthase domain containing 4	51					pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(8)|skin(1)	17	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0761)		TTTCTGGGCTCGGAGCTTCTC	0.567000													61	80					0	0	1	0	0
STAG1	10274	broad.mit.edu	37	3	136192446	136192446	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:136192446G>C	ENST00000383202.2	-	11	1316	c.1060C>G	c.(1060-1062)Ctg>Gtg	p.L354V	STAG1_ENST00000236698.5_Missense_Mutation_p.L354V|STAG1_ENST00000434713.2_Missense_Mutation_p.L128V	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	354	SCD.				cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						AGACTCTGCAGAGCTTTCAAA	0.338000													22	49					0	0	1	0	0
OR51G1	79324	broad.mit.edu	37	11	4944672	4944672	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:4944672G>T	ENST00000321961.2	-	1	965	c.898C>A	c.(898-900)Caa>Aaa	p.Q300K	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005237.1	NP_001005237.1	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G, member 1	300					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(3)|skin(4)|soft_tissue(1)	25		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGCGAATTTGCTTGGTCTTG	0.423000													16	42					0.000308642	0.000315926	1	1	0
IRGQ	126298	broad.mit.edu	37	19	44097062	44097062	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:44097062G>A	ENST00000422989.1	-	3	1143	c.988C>T	c.(988-990)Cgc>Tgc	p.R330C	IRGQ_ENST00000602269.1_Missense_Mutation_p.R330C|IRGQ_ENST00000601520.1_5'UTR|L34079.2_ENST00000594374.1_Missense_Mutation_p.R43C	NM_001007561.2	NP_001007562.1	Q8WZA9	IRGQ_HUMAN	immunity-related GTPase family, Q	330							protein binding			endometrium(2)|large_intestine(4)|lung(6)|ovary(2)|pancreas(1)|prostate(3)	18		Prostate(69;0.0199)				CCGTCTGTGCGCACGCAGACA	0.632000													13	264					0	0	1	0	0
TBX5	6910	broad.mit.edu	37	12	114823367	114823367	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:114823367C>T	ENST00000310346.4	-	7	1335	c.669G>A	c.(667-669)acG>acA	p.T223T	TBX5_ENST00000405440.2_Silent_p.T223T|TBX5_ENST00000349716.5_Silent_p.T173T|TBX5_ENST00000526441.1_Silent_p.T223T	NM_000192.3	NP_000183.2	Q99593	TBX5_HUMAN	T-box 5	223					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding	p.T223T(2)		endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(29)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		TCTTTAATTGCGTGATCTGAA	0.418000													5	23					0	0	1	0	0
IFIT3	3437	broad.mit.edu	37	10	91099693	91099693	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:91099693G>A	ENST00000371818.4	+	2	1461	c.1281G>A	c.(1279-1281)caG>caA	p.Q427Q	LIPA_ENST00000371837.1_Intron|LIPA_ENST00000487618.1_Intron|IFIT3_ENST00000371811.4_Silent_p.Q427Q	NM_001549.4	NP_001540.2	O14879	IFIT3_HUMAN	interferon-induced protein with tetratricopeptide repeats 3	427					type I interferon-mediated signaling pathway		protein binding			breast(1)|central_nervous_system(3)|endometrium(1)|large_intestine(4)|lung(3)|skin(2)|urinary_tract(1)	15						TTCATAAGCAGAATGGAGATC	0.433000													8	51					0	0	1	0	0
ZNF223	7766	broad.mit.edu	37	19	44531625	44531625	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:44531625A>T	ENST00000591793.1	+	3	328	c.245A>T	c.(244-246)cAa>cTa	p.Q82L	ZNF222_ENST00000587846.1_Missense_Mutation_p.Q82L|ZNF222_ENST00000187879.8_Intron|ZNF222_ENST00000391960.3_Missense_Mutation_p.Q82L|ZNF222_ENST00000590160.1_3'UTR			Q9UK11	ZN223_HUMAN	zinc finger protein 223	73					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	18		Prostate(69;0.0352)				ACAACAAGCCAAAGAGAAGGG	0.453000													107	57					0	0	1	0	0
PLOD2	5352	broad.mit.edu	37	3	145790403	145790403	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:145790403T>A	ENST00000282903.5	-	17	1970	c.1793A>T	c.(1792-1794)gAt>gTt	p.D598V	RP11-274H2.2_ENST00000480247.1_RNA|PLOD2_ENST00000494950.1_Missense_Mutation_p.D543V|PLOD2_ENST00000360060.3_Missense_Mutation_p.D577V|PLOD2_ENST00000461497.1_Missense_Mutation_p.D258V	NM_182943.2	NP_891988.1	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	577			R -> H (in BRKS2).		protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29					Vitamin C(DB00126)	TACCAATTCATCACAGGCTTT	0.363000													12	39					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38743601	38743601	+	Splice_Site	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:38743601C>G	ENST00000449082.2	-	26	4386		c.e26-1			NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit						sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GGAACTTGTTCTGAGAAAACA	0.468000													16	66					0	0	1	0	0
RPTOR	57521	broad.mit.edu	37	17	78519560	78519560	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:78519560C>G	ENST00000306801.3	+	1	493	c.131C>G	c.(130-132)tCc>tGc	p.S44C	RPTOR_ENST00000570891.1_Missense_Mutation_p.S44C|RPTOR_ENST00000544334.2_Missense_Mutation_p.S44C|RPTOR_ENST00000537330.1_5'UTR	NM_020761.2	NP_065812.1	Q8N122	RPTOR_HUMAN	regulatory associated protein of MTOR, complex 1	44					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(3)	44						GGCTCCAAATCCTTAGCTCAG	0.478000													20	91					0	0	1	0	0
PBLD	64081	broad.mit.edu	37	10	70048284	70048284	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:70048284C>G	ENST00000358769.2	-	8	849	c.647G>C	c.(646-648)aGa>aCa	p.R216T	PBLD_ENST00000336578.1_Missense_Mutation_p.R183T|PBLD_ENST00000432941.1_Missense_Mutation_p.R216T|PBLD_ENST00000495025.2_Missense_Mutation_p.R216T|PBLD_ENST00000309049.4_Missense_Mutation_p.R216T	NM_022129.3	NP_071412.2	P30039	PBLD_HUMAN	phenazine biosynthesis-like protein domain containing	216					biosynthetic process		isomerase activity			endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	21						TGCAAAATATCTTGAGTAAAA	0.468000													16	50					0	0	1	0	0
OR5D18	219438	broad.mit.edu	37	11	55587908	55587908	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:55587908C>G	ENST00000333976.4	+	1	823	c.803C>G	c.(802-804)tCc>tGc	p.S268C		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	268					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				TCCAAAAACTCCAGGCACACA	0.507000													32	59					0	0	1	0	0
C7orf33	202865	broad.mit.edu	37	7	148312489	148312489	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:148312489G>A	ENST00000307003.2	+	3	891	c.530G>A	c.(529-531)aGt>aAt	p.S177N		NM_145304.2	NP_660347.1	Q8WU49	CG033_HUMAN	chromosome 7 open reading frame 33	177										central_nervous_system(1)|large_intestine(4)|lung(7)|prostate(2)	14	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			ACTGACAGCAGTTAAGAATTT	0.378000													20	72					0	0	1	0	0
WDR11	55717	broad.mit.edu	37	10	122626260	122626260	+	Silent	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:122626260C>A	ENST00000263461.6	+	8	1420	c.1174C>A	c.(1174-1176)Cga>Aga	p.R392R		NM_018117.11	NP_060587.8	Q9BZH6	WDR11_HUMAN	WD repeat domain 11	392						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(9)|prostate(2)|skin(2)|stomach(5)	38						AGTTTGTAATCGAAATTCACG	0.393000													31	56					2.81731e-10	3.0646e-10	1	1	0
PSG2	5670	broad.mit.edu	37	19	43579628	43579628	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:43579628G>C	ENST00000406487.1	-	3	685	c.587C>G	c.(586-588)tCc>tGc	p.S196C		NM_031246.3	NP_112536.2	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	196	Ig-like C2-type 1.				cell migration|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(24)|ovary(1)|pancreas(2)|prostate(6)|stomach(2)|urinary_tract(2)	49		Prostate(69;0.00682)				GTTGGTTTCGGACAGCTGAAA	0.493000													126	814					0	0	1	0	0
RPL3L	6123	broad.mit.edu	37	16	1996698	1996698	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr16:1996698C>T	ENST00000268661.7	-	7	973	c.879G>A	c.(877-879)atG>atA	p.M293I		NM_005061.2	NP_005052.1	Q92901	RL3L_HUMAN	ribosomal protein L3-like	293					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	17						TCCCGTCCTCCATGTGCGGGC	0.652000													9	30					0	0	1	0	0
IMPG2	50939	broad.mit.edu	37	3	100992518	100992518	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:100992518G>A	ENST00000193391.7	-	7	922	c.735C>T	c.(733-735)ttC>ttT	p.F245F		NM_016247.3	NP_057331.2	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	245	SEA 1.				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			NS(1)|breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(14)|lung(32)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						GGTGGATACTGAATTCTGCAA	0.403000													11	24					0	0	1	0	0
DDX31	64794	broad.mit.edu	37	9	135523856	135523856	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:135523856T>A	ENST00000372159.3	-	10	1289	c.1138A>T	c.(1138-1140)Agt>Tgt	p.S380C	DDX31_ENST00000372153.1_Missense_Mutation_p.S380C|DDX31_ENST00000438527.3_Missense_Mutation_p.S251C|DDX31_ENST00000310532.2_Missense_Mutation_p.S380C	NM_022779.7	NP_073616.6	Q9H8H2	DDX31_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 31	380	Helicase ATP-binding.					nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(1)	27				OV - Ovarian serous cystadenocarcinoma(145;2.67e-06)|Epithelial(140;7.61e-05)		CGCAGCCGACTAAAATGAATG	0.433000													37	112					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30934813	30934813	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:30934813C>A	ENST00000355537.3	+	2	491	c.344C>A	c.(343-345)tCc>tAc	p.S115Y		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	115					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GGCATCATGTCCCAGATGAGC	0.642000													6	70					0.0215528	0.0216777	1	1	0
CYP27B1	1594	broad.mit.edu	37	12	58158842	58158842	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:58158842C>A	ENST00000228606.4	-	4	951	c.742G>T	c.(742-744)Ggg>Tgg	p.G248W		NM_000785.3	NP_000776.1	O15528	CP27B_HUMAN	cytochrome P450, family 27, subfamily B, polypeptide 1	248					bone mineralization|calcium ion homeostasis|calcium ion transport|decidualization|G1 to G0 transition|hormone biosynthetic process|negative regulation of calcidiol 1-monooxygenase activity|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of keratinocyte differentiation|positive regulation of vitamin D 24-hydroxylase activity|positive regulation of vitamin D receptor signaling pathway|regulation of bone mineralization|response to estrogen stimulus|response to interferon-gamma|response to lipopolysaccharide|response to tumor necrosis factor|response to vitamin D|vitamin D biosynthetic process|xenobiotic metabolic process	mitochondrial outer membrane	calcidiol 1-monooxygenase activity|electron carrier activity|heme binding			central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|urinary_tract(1)	15	all_cancers(7;8.09e-80)|Lung NSC(6;2.26e-27)|all_lung(6;1.99e-25)|all_epithelial(6;3.62e-18)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;1.97e-113)|all cancers(5;1.54e-78)|BRCA - Breast invasive adenocarcinoma(9;0.0294)		Calcidiol(DB00146)|Calcitriol(DB00136)|Ergocalciferol(DB00153)	CCCCAGGGCCCAGGCACAAGG	0.622000											OREG0021953	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	54					7.93312e-07	8.44415e-07	1	1	0
KCNQ4	9132	broad.mit.edu	37	1	41282936	41282936	+	Splice_Site	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:41282936G>C	ENST00000347132.5	+	2	396		c.e2-1		KCNQ4_ENST00000509682.2_Splice_Site	NM_004700.3|NM_172163.2	NP_004691.2|NP_751895.1	P56696	KCNQ4_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 4						sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(13)|skin(1)	26	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			TGTAATTGCAGATTTTTGCTG	0.522000													4	28					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178952085	178952085	+	Missense_Mutation	SNP	A	A	T	rs121913279		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:178952085A>T	ENST00000263967.3	+	21	3297	c.3140A>T	c.(3139-3141)cAt>cTt	p.H1047L		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1387)|p.H1047L(194)|p.H1047P(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378000	H1047L(EFM19_BREAST)|H1047R(BT20_BREAST)|H1047R(CAL29_URINARY_TRACT)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(HCC1954_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(MCAS_OVARY)|H1047R(MDAMB453_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(RKO_LARGE_INTESTINE)|H1047R(SKOV3_OVARY)|H1047R(T47D_BREAST)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			41	55					0	0	1	0	0
PPFIA3	8541	broad.mit.edu	37	19	49643235	49643235	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:49643235C>T	ENST00000334186.4	+	18	2607	c.2258C>T	c.(2257-2259)tCt>tTt	p.S753F	PPFIA3_ENST00000602351.1_Missense_Mutation_p.S753F	NM_003660.2	NP_003651.1	O75145	LIPA3_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	753						cell surface|cytoplasm	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(16)|pancreas(1)|prostate(1)|skin(4)|urinary_tract(1)	35		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		ACCCCAGATTCTCTGCACAAA	0.562000													68	110					0	0	1	0	0
MEFV	4210	broad.mit.edu	37	16	3298929	3298929	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr16:3298929C>G	ENST00000219596.1	-	4	1375	c.1336G>C	c.(1336-1338)Gag>Cag	p.E446Q	MEFV_ENST00000339854.4_Missense_Mutation_p.E266Q|MEFV_ENST00000536379.1_Missense_Mutation_p.E235Q|MEFV_ENST00000541159.1_Missense_Mutation_p.E235Q	NM_000243.2	NP_000234.1	O15553	MEFV_HUMAN	Mediterranean fever	446					inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			NS(2)|biliary_tract(1)|breast(5)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(3)|prostate(1)|skin(6)	50					Colchicine(DB01394)	ACTGCCTTCTCCTCCCCATAG	0.532000													20	128					0	0	1	0	0
OOSP2	219990	broad.mit.edu	37	11	59807984	59807984	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:59807984G>A	ENST00000278855.2	+	1	237	c.52G>A	c.(52-54)Gag>Aag	p.E18K	PLAC1L_ENST00000532905.1_5'UTR	NM_173801.3	NP_776162.2	Q86WS3	PLACL_HUMAN		18						extracellular region				breast(1)|lung(9)|ovary(2)|prostate(2)|skin(1)	15						GACCGGTGCTGAGAACCTCCA	0.458000													31	79					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80658990	80658990	+	Splice_Site	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:80658990G>T	ENST00000458043.2	+	19	2203	c.2197G>T	c.(2197-2199)Gct>Tct	p.A733S	OTOGL_ENST00000547103.1_Splice_Site_p.A733S	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						TTCTTTCTGTGGTGAGTACAA	0.418000													13	17					2.27111e-07	2.43986e-07	1	1	0
CHD2	1106	broad.mit.edu	37	15	93563489	93563489	+	Splice_Site	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr15:93563489G>A	ENST00000394196.4	+	38	6221		c.e38+1		CHD2_ENST00000557381.1_Silent_p.R1718R	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2						regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			ATTATGACAGGTATGCAAAAG	0.463000													17	26					0	0	1	0	0
PFKL	5211	broad.mit.edu	37	21	45746744	45746744	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr21:45746744G>A	ENST00000403390.1	+	23	2483	c.2483G>A	c.(2482-2484)tGa>tAa	p.*828*	PFKL_ENST00000349048.4_Silent_p.*781*			P17858	K6PL_HUMAN	phosphofructokinase, liver	0					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	23				Colorectal(79;0.0811)		AAGGGCTTCTGAGGCCAGCCA	0.667000													5	4					0	0	1	0	0
PBX1	5087	broad.mit.edu	37	1	164769086	164769086	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:164769086G>A	ENST00000420696.2	+	4	849	c.661G>A	c.(661-663)Gag>Aag	p.E221K	PBX1_ENST00000367897.1_Missense_Mutation_p.E221K|PBX1_ENST00000559240.1_Missense_Mutation_p.E221K|PBX1_ENST00000540236.1_Missense_Mutation_p.E221K|PBX1_ENST00000401534.1_Missense_Mutation_p.E221K|PBX1_ENST00000540246.1_Missense_Mutation_p.E116K|PBX1_ENST00000560641.1_Missense_Mutation_p.E116K	NM_001204961.1|NM_001204963.1|NM_002585.3	NP_001191890.1|NP_001191892.1|NP_002576.1	P40424	PBX1_HUMAN	pre-B-cell leukemia homeobox 1	221					negative regulation of sequence-specific DNA binding transcription factor activity|sex differentiation|steroid biosynthetic process	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription factor binding		EWSR1/PBX1(3)	large_intestine(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	4						GAGCACGTGCGAGGCGGTGAT	0.612000			T	"""TCF3, EWSR1"""	"""pre B-ALL, myoepithelioma"""								8	112					0	0	1	0	0
NFATC3	4775	broad.mit.edu	37	16	68248244	68248244	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr16:68248244C>T	ENST00000329524.4	+	10	3143	c.3119C>T	c.(3118-3120)tCt>tTt	p.S1040F	NFATC3_ENST00000535127.2_3'UTR|RP11-96D1.5_ENST00000569088.1_RNA|NFATC3_ENST00000575270.1_Intron|NFATC3_ENST00000349223.5_Intron|NFATC3_ENST00000346183.3_Intron	NM_004555.3	NP_004546.1	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	0					inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	44		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		CAATTTATATCTGACTTGGAA	0.443000													6	47					0	0	1	0	0
VPS52	6293	broad.mit.edu	37	6	33235699	33235699	+	Silent	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:33235699C>G	ENST00000445902.2	-	9	1094	c.876G>C	c.(874-876)ctG>ctC	p.L292L	VPS52_ENST00000478934.1_5'UTR|VPS52_ENST00000436044.2_Silent_p.L167L|VPS52_ENST00000482399.1_3'UTR	NM_022553.4	NP_072047.4	Q8N1B4	VPS52_HUMAN	vacuolar protein sorting 52 homolog (S. cerevisiae)	292					protein transport	endosome membrane|Golgi apparatus				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(8)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	28						AAATCTTGCTCAGCGTCTCCA	0.522000													29	44					0	0	1	0	0
RPS20	6224	broad.mit.edu	37	8	56986683	56986683	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:56986683C>T	ENST00000519807.1	-	2	164	c.39G>A	c.(37-39)ccG>ccA	p.P13P	RPS20_ENST00000519606.1_Silent_p.P13P|RPS20_ENST00000520627.1_Intron|RPS20_ENST00000524349.1_5'UTR|RPS20_ENST00000521262.1_Silent_p.P13P|RPS20_ENST00000518875.1_Silent_p.P13P|RPS20_ENST00000523936.1_Silent_p.P13P|RPS20_ENST00000520490.1_5'UTR|RPS20_ENST00000009589.3_Silent_p.P13P	NM_001146227.1	NP_001139699.1	P60866	RS20_HUMAN	ribosomal protein S20	13					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome						all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.155)	Epithelial(17;0.00117)|all cancers(17;0.00879)			TTGCCACCTCCGGCTCCACGG	0.463000													11	98					0	0	1	0	0
CDR1	1038	broad.mit.edu	37	X	139866323	139866323	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chrX:139866323G>A	ENST00000370532.2	-	1	400	c.209C>T	c.(208-210)tCg>tTg	p.S70L		NM_004065.2	NP_004056.2	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1, 34kDa	70	23 X 6 AA approximate repeats.									breast(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(2)|skin(4)|urinary_tract(1)	25	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				CATAGCTTCCGAAAAATCCAG	0.453000													34	40					0	0	1	0	0
THEMIS2	9473	broad.mit.edu	37	1	28208582	28208582	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:28208582G>A	ENST00000373921.3	+	4	751	c.747G>A	c.(745-747)ctG>ctA	p.L249L	THEMIS2_ENST00000328928.7_Silent_p.L249L|THEMIS2_ENST00000373925.1_Intron|THEMIS2_ENST00000373927.3_Intron	NM_001105556.1	NP_001099026.1			thymocyte selection associated family member 2																		CGCTGCTGCTGAGCGAGGTCC	0.637000													15	46					0	0	1	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73067780	73067780	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:73067780G>A	ENST00000263674.3	+	7	4217	c.3867G>A	c.(3865-3867)ctG>ctA	p.L1289L		NM_014786.3	NP_055601.2	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1289					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(2)	32						GGCGGTTCCTGAGACAGGAGA	0.552000													7	35					0	0	1	0	0
TMEM132D	121256	broad.mit.edu	37	12	130184385	130184385	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:130184385C>G	ENST00000422113.2	-	2	1264	c.938G>C	c.(937-939)aGa>aCa	p.R313T		NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	313						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		AGTGGAATTTCTGGAGATGGA	0.502000													6	39					0	0	1	0	0
ZNF33B	7582	broad.mit.edu	37	10	43088096	43088096	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:43088096G>A	ENST00000359467.3	-	5	2416	c.2302C>T	c.(2302-2304)Cag>Tag	p.Q768*	ZNF33B_ENST00000486187.1_RNA	NM_006955.1	NP_008886.1	Q06732	ZN33B_HUMAN	zinc finger protein 33B	768						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(15)|skin(1)|stomach(1)	29						TGTGTTCTCTGATGTACAATG	0.398000													26	175					0	0	1	0	0
C10orf88	80007	broad.mit.edu	37	10	124708192	124708192	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:124708192C>T	ENST00000481909.1	-	4	845	c.621G>A	c.(619-621)ttG>ttA	p.L207L	C10orf88_ENST00000368891.5_5'UTR	NM_024942.3	NP_079218.2	Q9H8K7	CJ088_HUMAN	chromosome 10 open reading frame 88	207										breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)	18		all_neural(114;0.0765)|Lung NSC(174;0.163)|all_lung(145;0.205)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0735)		CCATATCCATCAACTGCTGAG	0.413000													10	42					0	0	1	0	0
PPM1G	5496	broad.mit.edu	37	2	27608625	27608625	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:27608625T>A	ENST00000344034.4	-	4	662	c.398A>T	c.(397-399)gAt>gTt	p.D133V	PPM1G_ENST00000350803.4_Missense_Mutation_p.D133V	NM_177983.2	NP_817092.1	O15355	PPM1G_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1G	133					cell cycle arrest|protein dephosphorylation	cytoplasm|nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	19	Acute lymphoblastic leukemia(172;0.155)					ATCATCTTCATCAGCTACTTT	0.393000													32	66					0	0	1	0	0
LST3	0	broad.mit.edu	37	12	21229431	21229431	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:21229431C>T	ENST00000540229.1	+	15	2041	c.1976C>T	c.(1975-1977)aCg>aTg	p.T659M	LST3_ENST00000381541.3_Missense_Mutation_p.T598M|RP11-125O5.2_ENST00000590779.1_Missense_Mutation_p.R52C|SLCO1B7_ENST00000421593.2_Missense_Mutation_p.T551M|SLCO1B3_ENST00000553473.1_Missense_Mutation_p.T659M|SLCO1B7_ENST00000554957.1_Missense_Mutation_p.T598M																							ATTGATACAACGTGTATGAAG	0.363000													29	84					0	0	1	0	0
ZMIZ1	57178	broad.mit.edu	37	10	81063832	81063832	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:81063832A>C	ENST00000334512.5	+	19	2758	c.2186A>C	c.(2185-2187)gAt>gCt	p.D729A		NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	729					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			AACGGGGAGGATGGGGTGGAG	0.617000													10	36					0	0	1	0	0
CCNT1	904	broad.mit.edu	37	12	49087819	49087819	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:49087819C>A	ENST00000261900.3	-	9	1400	c.1178G>T	c.(1177-1179)cGc>cTc	p.R393L		NM_001240.3	NP_001231.2	O60563	CCNT1_HUMAN	cyclin T1	393					cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|skin(2)	27						ATGCTTCGCGCGGTATTCTTT	0.448000													32	160					3.99451e-17	4.50031e-17	1	1	0
UNC93B1	81622	broad.mit.edu	37	11	67766749	67766749	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:67766749G>C	ENST00000227471.2	-	5	660	c.581C>G	c.(580-582)tCc>tGc	p.S194C	UNC93B1_ENST00000530331.1_5'UTR	NM_030930.2	NP_112192.2	Q9H1C4	UN93B_HUMAN	unc-93 homolog B1 (C. elegans)	194					innate immune response|intracellular protein transport|response to virus|toll-like receptor 3 signaling pathway|toll-like receptor 7 signaling pathway|toll-like receptor 9 signaling pathway	early phagosome|endoplasmic reticulum membrane|endosome|integral to membrane|lysosome											CTTGTAGTGGGAGTACTCATG	0.612000													17	17					0	0	1	0	0
FCRL3	115352	broad.mit.edu	37	1	157650526	157650526	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:157650526C>T	ENST00000368184.3	-	13	2283	c.1992G>A	c.(1990-1992)caG>caA	p.Q664Q	FCRL3_ENST00000473231.1_5'UTR|FCRL3_ENST00000368186.5_Silent_p.Q664Q	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	664						integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					TGCTCCAGATCTGGGAATAAA	0.433000													31	53					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167674760	167674760	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:167674760G>C	ENST00000519204.1	+	26	6571	c.6453G>C	c.(6451-6453)caG>caC	p.Q2151H	TENM2_ENST00000520394.1_Missense_Mutation_p.Q2033H|TENM2_ENST00000518659.1_Missense_Mutation_p.Q2272H|TENM2_ENST00000545108.1_Missense_Mutation_p.Q2271H|TENM2_ENST00000403607.2_Missense_Mutation_p.Q2096H					teneurin transmembrane protein 2																		ATCTGTGCCAGAGAGGGTCTG	0.542000													12	58					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41076526	41076526	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:41076526A>T	ENST00000352632.3	+	33	7297	c.7211A>T	c.(7210-7212)cAg>cTg	p.Q2404L	SPTBN4_ENST00000392025.1_Missense_Mutation_p.Q1147L|SPTBN4_ENST00000598249.1_Missense_Mutation_p.Q2404L			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	2404					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			gccccggcccagggcggctcc	0.786000													4	2					0	0	1	0	0
TRIM68	55128	broad.mit.edu	37	11	4623543	4623543	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:4623543C>T	ENST00000300747.5	-	4	911	c.622G>A	c.(622-624)Gag>Aag	p.E208K		NM_018073.6	NP_060543.5	Q6AZZ1	TRI68_HUMAN	tripartite motif containing 68	208					protein autoubiquitination|regulation of androgen receptor signaling pathway	Golgi apparatus|nucleolus|perinuclear region of cytoplasm	androgen receptor binding|histone acetyltransferase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(4)|ovary(1)|urinary_tract(1)	15		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;9.49e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		GCTGCTACCTCTGCCCCCAGC	0.537000													18	24					0	0	1	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57069342	57069342	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:57069342G>A	ENST00000532437.1	-	8	5221	c.4910C>T	c.(4909-4911)tCg>tTg	p.S1637L	TNKS1BP1_ENST00000358252.3_Missense_Mutation_p.S1637L			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	1637	Arg/Glu/Lys-rich (charged).				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				GGTGCCCAACGACATCCGTGT	0.582000													4	56					0	0	1	0	0
GARNL3	84253	broad.mit.edu	37	9	130145727	130145727	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:130145727C>G	ENST00000373387.4	+	23	2524	c.2172C>G	c.(2170-2172)atC>atG	p.I724M	GARNL3_ENST00000314904.5_Missense_Mutation_p.I724M|GARNL3_ENST00000496711.1_3'UTR|GARNL3_ENST00000435213.2_Missense_Mutation_p.I702M	NM_032293.4	NP_115669.3	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	724	CNH.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			NS(1)|central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(24)|ovary(1)|skin(1)|urinary_tract(2)	41						ACAGTTGCATCTATAAAAAGG	0.383000													21	16					0	0	1	0	0
SHARPIN	81858	broad.mit.edu	37	8	145154091	145154091	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:145154091G>A	ENST00000398712.2	-	7	1376	c.940C>T	c.(940-942)Cag>Tag	p.Q314*		NM_030974.3	NP_112236.3	Q9H0F6	SHRPN_HUMAN	SHANK-associated RH domain interactor	314					negative regulation of inflammatory response|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein linear polyubiquitination|regulation of CD40 signaling pathway|regulation of tumor necrosis factor-mediated signaling pathway	cytosol|LUBAC complex	polyubiquitin binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|lung(2)|ovary(2)	7	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.1e-42)|Epithelial(56;1.58e-40)|all cancers(56;6.12e-36)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGGGGGTGCTGAGGGCTAGGT	0.672000													13	18					0	0	1	0	0
EED	8726	broad.mit.edu	37	11	85977209	85977209	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:85977209A>T	ENST00000263360.6	+	8	1497	c.811A>T	c.(811-813)Atg>Ttg	p.M271L	EED_ENST00000528180.1_Intron|EED_ENST00000351625.6_Missense_Mutation_p.M271L|EED_ENST00000327320.4_Missense_Mutation_p.M271L	NM_003797.3	NP_003788.2	O75530	EED_HUMAN	embryonic ectoderm development	271	Interaction with EZH2 (By similarity).|Required for interaction with the matrix protein MA of HIV-1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	21		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				AAAGAGAATGATGAATGCAAT	0.303000													13	87					0	0	1	0	0
TCP11L2	255394	broad.mit.edu	37	12	106712230	106712230	+	Silent	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:106712230A>G	ENST00000546625.1	+	4	561	c.402A>G	c.(400-402)gaA>gaG	p.E134E	TCP11L2_ENST00000299045.3_Silent_p.E134E|TCP11L2_ENST00000547153.1_Silent_p.E134E			Q8N4U5	T11L2_HUMAN	t-complex 11, testis-specific-like 2	134										endometrium(2)|kidney(2)|large_intestine(5)|ovary(3)|prostate(1)|urinary_tract(2)	15						AACTGTTTGAAGAAATCAGAG	0.473000													15	46					0	0	1	0	0
ATF7IP	55729	broad.mit.edu	37	12	14589126	14589126	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:14589126G>A	ENST00000544627.1	+	4	2076	c.1756G>A	c.(1756-1758)Gag>Aag	p.E586K	ATF7IP_ENST00000536444.1_Missense_Mutation_p.E577K|ATF7IP_ENST00000541654.1_3'UTR|ATF7IP_ENST00000540793.1_Missense_Mutation_p.E578K|ATF7IP_ENST00000261168.4_Missense_Mutation_p.E578K|ATF7IP_ENST00000543189.1_Missense_Mutation_p.E577K			Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting protein	578	Interaction with SETDB1.				DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			cervix(1)|endometrium(7)|kidney(5)|large_intestine(10)|liver(2)|lung(22)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	54						AGAAGAATATGAGGCAGAATT	0.323000													31	51					0	0	1	0	0
PON3	5446	broad.mit.edu	37	7	94989396	94989396	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:94989396G>A	ENST00000265627.5	-	9	964	c.954C>T	c.(952-954)acC>acT	p.T318T	PON1_ENST00000542556.1_Intron|PON3_ENST00000451904.1_3'UTR|PON3_ENST00000427422.1_3'UTR	NM_000940.2	NP_000931.1			paraoxonase 3											breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	24	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			TGGCATACACGGTGCTCACCC	0.443000													30	46					0	0	1	0	0
KRT5	3852	broad.mit.edu	37	12	52910468	52910468	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:52910468G>A	ENST00000252242.4	-	7	1782	c.1392C>T	c.(1390-1392)gaC>gaT	p.D464D		NM_000424.3	NP_000415.2	P13647	K2C5_HUMAN	keratin 5	464	Coil 2.|Rod.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(5)|kidney(1)|large_intestine(8)|lung(15)|prostate(4)|skin(2)	35				BRCA - Breast invasive adenocarcinoma(357;0.189)		CGATCTCCACGTCCAGGGCCA	0.602000													30	105					0	0	1	0	0
SLC2A1	6513	broad.mit.edu	37	1	43395392	43395392	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:43395392C>T	ENST00000426263.3	-	6	917	c.739G>A	c.(739-741)Gag>Aag	p.E247K	SLC2A1_ENST00000475162.1_Intron|SLC2A1_ENST00000415851.2_Intron	NM_006516.2	NP_006507.2	P11166	GTR1_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 1	247					carbohydrate metabolic process|energy reserve metabolic process|regulation of insulin secretion|water-soluble vitamin metabolic process	integral to membrane|melanosome|membrane fraction|midbody	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|pancreas(2)	13	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0122)			Etomidate(DB00292)	TGCCGACTCTCTTCCTTCATC	0.627000													60	124					0	0	1	0	0
ERBB3	2065	broad.mit.edu	37	12	56477672	56477672	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:56477672C>T	ENST00000267101.3	+	2	660	c.220C>T	c.(220-222)Ctc>Ttc	p.L74F	ERBB3_ENST00000450146.2_Intron|ERBB3_ENST00000411731.2_Missense_Mutation_p.L74F|ERBB3_ENST00000415288.2_Missense_Mutation_p.L15F	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	74					cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CAATGCCGACCTCTCCTTCCT	0.537000													27	71					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71500195	71500195	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr4:71500195G>A	ENST00000396073.3	+	6	662	c.381G>A	c.(379-381)caG>caA	p.Q127Q		NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	127					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			AACCCAACCAGACTCAGTCAA	0.522000													11	23					0	0	1	0	0
PCDHA12	56137	broad.mit.edu	37	5	140256681	140256681	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:140256681G>T	ENST00000398631.2	+	1	1624	c.1624G>T	c.(1624-1626)Gtg>Ttg	p.V542L	PCDHA11_ENST00000398640.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA6_ENST00000527624.1_Intron	NM_018903.2|NM_031864.2	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGACGCCGGCGTGCCGCCTCT	0.701000													43	79					2.24893e-16	2.51735e-16	1	1	0
ALAS2	212	broad.mit.edu	37	X	55050275	55050275	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chrX:55050275G>A	ENST00000330807.5	-	4	467	c.330C>T	c.(328-330)gtC>gtT	p.V110V	ALAS2_ENST00000396198.3_Intron|ALAS2_ENST00000335854.4_Intron	NM_000032.4	NP_000023.2	P22557	HEM0_HUMAN	aminolevulinate, delta-, synthase 2	110					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			central_nervous_system(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|prostate(2)|skin(1)	17					Glycine(DB00145)	TCCTTAGGCTGACTGAGACCA	0.507000													3	6					0	0	1	0	0
DENND2A	27147	broad.mit.edu	37	7	140255469	140255469	+	Silent	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:140255469C>G	ENST00000275884.6	-	11	2421	c.2004G>C	c.(2002-2004)gtG>gtC	p.V668V	DENND2A_ENST00000496613.1_Silent_p.V668V|DENND2A_ENST00000537639.1_Silent_p.V668V|DENND2A_ENST00000492720.1_Silent_p.V668V			Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	668	DENN.									breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(22)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49	Melanoma(164;0.00956)					CCAGGCGGCTCACAATGCAGT	0.522000													20	72					0	0	1	0	0
C5orf42	65250	broad.mit.edu	37	5	37195984	37195984	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:37195984C>T	ENST00000274258.7	-	21	4017	c.430G>A	c.(430-432)Gat>Aat	p.D144N	C5orf42_ENST00000508244.1_Missense_Mutation_p.D1263N|C5orf42_ENST00000425232.2_Missense_Mutation_p.D1263N			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	1263										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			GAAACTTCATCAAGCTTGTGG	0.378000													10	70					0	0	1	0	0
RBM15	64783	broad.mit.edu	37	1	110882503	110882503	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:110882503C>G	ENST00000369784.3	+	1	1376	c.476C>G	c.(475-477)tCa>tGa	p.S159*	RBM15_ENST00000487146.2_Nonsense_Mutation_p.S159*|RBM15_ENST00000602849.1_Nonsense_Mutation_p.S159*	NM_022768.4	NP_073605.4	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	159	Gly/Ser-rich.				interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		GCCGCCTCCTCAGCTCCCGGC	0.642000			T	MKL1	acute megakaryocytic leukemia						OREG0013656	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	32					0	0	1	0	0
ITM2C	81618	broad.mit.edu	37	2	231738161	231738161	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:231738161G>C	ENST00000326427.6	+	2	276	c.150G>C	c.(148-150)aaG>aaC	p.K50N	ITM2C_ENST00000492029.1_3'UTR|ITM2C_ENST00000409704.2_5'UTR|ITM2C_ENST00000326407.6_Missense_Mutation_p.K50N|ITM2C_ENST00000335005.6_Intron	NM_030926.4	NP_112188.1	Q9NQX7	ITM2C_HUMAN	integral membrane protein 2C	50					negative regulation of neuron projection development|neuron differentiation	Golgi apparatus|integral to membrane|lysosomal membrane|perinuclear region of cytoplasm	beta-amyloid binding			cervix(2)|lung(1)|ovary(1)|skin(1)	5		Renal(207;0.0112)|all_lung(227;0.0741)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)|Lung NSC(271;0.204)		Epithelial(121;8.47e-12)|all cancers(144;3.44e-09)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		ATCGATCCAAGAGGGGGGGCT	0.612000													6	27					0	0	1	0	0
TRPC6	7225	broad.mit.edu	37	11	101347251	101347251	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:101347251C>T	ENST00000344327.3	-	6	1949	c.1525G>A	c.(1525-1527)Gaa>Aaa	p.E509K	TRPC6_ENST00000532133.1_Intron|TRPC6_ENST00000348423.4_Missense_Mutation_p.E393K|TRPC6_ENST00000360497.4_Missense_Mutation_p.E454K	NM_004621.5	NP_004612.2	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel, subfamily C, member 6	509					axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(14)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		TCTTTACATTCAGCCCATATC	0.378000													25	27					0	0	1	0	0
ZBTB41	360023	broad.mit.edu	37	1	197160945	197160945	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:197160945G>C	ENST00000367405.4	-	2	1273	c.1205C>G	c.(1204-1206)tCt>tGt	p.S402C	ZBTB41_ENST00000467322.1_5'UTR	NM_194314.2	NP_919290.2	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	402					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(11)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	40						AGTTAGGTTAGACTTTGTTGA	0.383000													10	28					0	0	1	0	0
DDA1	79016	broad.mit.edu	37	19	17426805	17426805	+	Splice_Site	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:17426805G>T	ENST00000359866.4	+	4	322		c.e4+1			NM_024050.5	NP_076955.1	Q9BW61	DDA1_HUMAN	DET1 and DDB1 associated 1											kidney(1)|large_intestine(1)|lung(1)|ovary(1)	4						GGACAAAAAGGTGAGGCCCAC	0.552000													34	175					3.90053e-15	4.32423e-15	1	1	0
NME8	51314	broad.mit.edu	37	7	37934072	37934072	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:37934072G>C	ENST00000199447.4	+	16	1776	c.1404G>C	c.(1402-1404)caG>caC	p.Q468H	NME8_ENST00000440017.1_Missense_Mutation_p.Q468H|EPDR1_ENST00000476620.1_Intron	NM_016616.4	NP_057700.3	Q8N427	TXND3_HUMAN	NME/NM23 family member 8	468	NDK 3.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity										TCTTAGAGCAGATCCTGAAGA	0.328000													13	40					0	0	1	0	0
GRK6	2870	broad.mit.edu	37	5	176863486	176863486	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:176863486C>T	ENST00000355472.5	+	13	1527	c.1359C>T	c.(1357-1359)ttC>ttT	p.F453F	GRK6_ENST00000507633.1_Silent_p.F453F|GRK6_ENST00000393576.3_Silent_p.F419F|GRK6_ENST00000528793.1_Silent_p.F453F|GRK6_ENST00000355958.5_Silent_p.F453F	NM_001004106.2|NM_002082.3	NP_001004106.1|NP_002073.2	P43250	GRK6_HUMAN	G protein-coupled receptor kinase 6	453	AGC-kinase C-terminal.				regulation of G-protein coupled receptor protein signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(5)|stomach(1)	25	all_cancers(89;1.15e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGCTGAACTTCAAGCGGCTGG	0.672000													20	32					0	0	1	0	0
MICAL2	9645	broad.mit.edu	37	11	12231097	12231097	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:12231097G>C	ENST00000256194.4	+	6	931	c.643G>C	c.(643-645)Gag>Cag	p.E215Q	MICAL2_ENST00000342902.5_Missense_Mutation_p.E215Q|MICAL2_ENST00000379612.3_Missense_Mutation_p.E215Q|MICAL2_ENST00000537344.1_Missense_Mutation_p.E215Q|MICAL2_ENST00000527546.1_Missense_Mutation_p.E215Q	NM_001282663.1|NM_014632.2	NP_001269592.1|NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	215						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		GTCGGAGTTTGAGTTTGACGT	0.532000													29	33					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238303321	238303321	+	Silent	SNP	A	A	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:238303321A>C	ENST00000295550.4	-	3	1070	c.618T>G	c.(616-618)ctT>ctG	p.L206L	COL6A3_ENST00000347401.3_Silent_p.L206L|COL6A3_ENST00000392003.2_Intron|COL6A3_ENST00000409809.1_Intron|COL6A3_ENST00000353578.4_Intron|COL6A3_ENST00000392004.3_Intron|COL6A3_ENST00000346358.4_Silent_p.L206L|COL6A3_ENST00000472056.1_Intron	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	206	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CTATGTCATGAAGTGAGGTAA	0.433000													11	37					0	0	1	0	0
TECPR1	25851	broad.mit.edu	37	7	97862208	97862208	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:97862208G>A	ENST00000447648.2	-	12	2048	c.1749C>T	c.(1747-1749)ttC>ttT	p.F583F	TECPR1_ENST00000379795.3_Silent_p.F584F|TECPR1_ENST00000542604.1_Silent_p.F513F			Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	583						integral to membrane	protein binding			central_nervous_system(2)|endometrium(8)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						TGAGCTGCTGGAAGATCTGCT	0.632000													5	21					0	0	1	0	0
OR8A1	390275	broad.mit.edu	37	11	124440753	124440753	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:124440753C>T	ENST00000284287.3	+	1	861	c.789C>T	c.(787-789)gcC>gcT	p.A263A		NM_001005194.1	NP_001005194.1	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A, member 1	263					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			haematopoietic_and_lymphoid_tissue(1)|lung(16)|ovary(2)|prostate(1)|skin(2)	22		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		ACCTTGCAGCCGTGGGAATGT	0.507000													28	31					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71500192	71500192	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr4:71500192C>A	ENST00000396073.3	+	6	659	c.378C>A	c.(376-378)aaC>aaA	p.N126K		NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	126					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			AGAAACCCAACCAGACTCAGT	0.522000													11	24					3.8784e-16	4.32735e-16	1	1	0
SLC6A15	55117	broad.mit.edu	37	12	85266933	85266933	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:85266933C>A	ENST00000266682.5	-	7	1583	c.1042G>T	c.(1042-1044)Gca>Tca	p.A348S	SLC6A15_ENST00000552192.1_Missense_Mutation_p.A241S|SLC6A15_ENST00000551388.1_5'UTR|SLC6A15_ENST00000309283.7_Missense_Mutation_p.A56S	NM_182767.5	NP_877499.1	Q9H2J7	S6A15_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 15	348					cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						ACCAATGTTGCCAGGACAGAA	0.393000													8	56					0.00307968	0.00313387	1	1	0
ST6GALNAC5	81849	broad.mit.edu	37	1	77516012	77516012	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:77516012G>C	ENST00000477717.1	+	4	976	c.741G>C	c.(739-741)agG>agC	p.R247S		NM_030965.1	NP_112227.1	Q9BVH7	SIA7E_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	247					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	18						TCTGTGACAGGATCAATGTTT	0.433000													40	82					0	0	1	0	0
DLC1	10395	broad.mit.edu	37	8	12957784	12957784	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:12957784A>T	ENST00000276297.4	-	9	2471	c.2062T>A	c.(2062-2064)Tca>Aca	p.S688T	DLC1_ENST00000358919.2_Missense_Mutation_p.S251T|DLC1_ENST00000520226.1_Missense_Mutation_p.S177T|DLC1_ENST00000512044.2_Missense_Mutation_p.S285T	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	688					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						CCCAGCTTTGAGGGCGCTTTG	0.562000													19	28					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121744054	121744054	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:121744054G>A	ENST00000452319.1	+	13	2217	c.2157G>A	c.(2155-2157)ctG>ctA	p.L719L	GLI2_ENST00000361492.4_Silent_p.L719L|GLI2_ENST00000314490.11_Silent_p.L391L			P10070	GLI2_HUMAN	GLI family zinc finger 2	719				QL -> HV (in Ref. 4; BAA03568/BAA03569).	axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				GCCTCCAGCTGCGCAAACACA	0.657000													6	21					0	0	1	0	0
ZAP70	7535	broad.mit.edu	37	2	98340656	98340656	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:98340656G>C	ENST00000264972.5	+	3	372	c.157G>C	c.(157-159)Gat>Cat	p.D53H		NM_001079.3	NP_001070.2	P43403	ZAP70_HUMAN	zeta-chain (TCR) associated protein kinase 70kDa	53	SH2 1.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	29						GCTCGTGCACGATGTGCGCTT	0.672000													13	11					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9090928	9090928	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:9090928G>A	ENST00000397910.4	-	1	1090	c.887C>T	c.(886-888)tCa>tTa	p.S296L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	296	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCTGGTCTCTGATATTTTATT	0.517000													43	46					0	0	1	0	0
ACRC	93953	broad.mit.edu	37	X	70811992	70811992	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chrX:70811992C>G	ENST00000373695.1	+	2	617	c.80C>G	c.(79-81)tCa>tGa	p.S27*	ACRC_ENST00000373696.3_Nonsense_Mutation_p.S27*			Q96QF7	ACRC_HUMAN	acidic repeat containing	27						nucleus				autonomic_ganglia(1)|breast(1)|endometrium(15)|kidney(4)|large_intestine(4)|lung(20)|ovary(5)|prostate(1)|skin(2)|stomach(1)	54	Renal(35;0.156)					AATGTTCAGTCAAGCAGTGAT	0.383000													15	16					0	0	1	0	0
PRG3	10394	broad.mit.edu	37	11	57147185	57147185	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:57147185T>A	ENST00000287143.2	-	3	266	c.157A>T	c.(157-159)Acg>Tcg	p.T53S		NM_006093.3	NP_006084.2	Q9Y2Y8	PRG3_HUMAN	proteoglycan 3	53					basophil activation|histamine biosynthetic process|immune response|leukotriene biosynthetic process|negative regulation of translation|neutrophil activation|positive regulation of interleukin-8 biosynthetic process|superoxide anion generation		sugar binding			large_intestine(3)|lung(5)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	13						ACCTCCTCCGTCAGAGCCAAG	0.562000													26	82					0	0	1	0	0
MGMT	4255	broad.mit.edu	37	10	131565235	131565235	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:131565235G>T	ENST00000306010.7	+	5	723	c.691G>T	c.(691-693)Ggc>Tgc	p.G231C		NM_002412.3	NP_002403.2	B4DEE8	B4DEE8_HUMAN	O-6-methylguanine-DNA methyltransferase	231										breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	10		all_cancers(35;9.44e-09)|all_epithelial(44;6.98e-08)|Lung NSC(174;0.0157)|all_lung(145;0.0201)|all_neural(114;0.0732)|Colorectal(57;0.0792)|Breast(234;0.167)		OV - Ovarian serous cystadenocarcinoma(35;0.00291)		AGCTACCTCGGGCTCCCCGCC	0.637000								Direct reversal of damage					8	17					5.18039e-06	5.39819e-06	1	1	0
LRP12	29967	broad.mit.edu	37	8	105511547	105511547	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:105511547G>A	ENST00000276654.5	-	4	581	c.473C>T	c.(472-474)tCa>tTa	p.S158L	LRP12_ENST00000424843.2_Missense_Mutation_p.S139L	NM_013437.4	NP_038465.1	Q9Y561	LRP12_HUMAN	low density lipoprotein receptor-related protein 12	158	CUB 1.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			AAACACACCTGAAAAATATGC	0.353000													8	123					0	0	1	0	0
MGAT4A	11320	broad.mit.edu	37	2	99294911	99294911	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:99294911C>T	ENST00000264968.3	-	2	481	c.118G>A	c.(118-120)Gaa>Aaa	p.E40K	MGAT4A_ENST00000409391.1_Missense_Mutation_p.E40K|MGAT4A_ENST00000393487.1_Missense_Mutation_p.E40K			Q9UM21	MGT4A_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A						N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|stomach(1)	19						GCAAGGAATTCTCGTTGATAA	0.338000													17	85					0	0	1	0	0
FAM101A	144347	broad.mit.edu	37	12	124798930	124798930	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:124798930C>G	ENST00000324038.3	+	3	510	c.267C>G	c.(265-267)atC>atG	p.I89M	FAM101A_ENST00000338359.4_Missense_Mutation_p.I89M|FAM101A_ENST00000389727.3_Missense_Mutation_p.I170M|FAM101A_ENST00000546355.1_Missense_Mutation_p.I89M	NM_181709.4	NP_859060.3	Q6ZTI6	F101A_HUMAN	family with sequence similarity 101, member A	170										endometrium(1)|kidney(1)|lung(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;2.38e-05)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-05)|all cancers(50;0.000361)|BRCA - Breast invasive adenocarcinoma(302;0.059)		CCACCATCATCTTCCCCAAGC	0.687000													28	40					0	0	1	0	0
TMEM200A	114801	broad.mit.edu	37	6	130762710	130762710	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:130762710G>T	ENST00000392429.1	+	2	3521	c.1143G>T	c.(1141-1143)caG>caT	p.Q381H	TMEM200A_ENST00000545622.1_Missense_Mutation_p.Q381H|TMEM200A_ENST00000296978.3_Missense_Mutation_p.Q381H	NM_052913.2	NP_443145.1	Q86VY9	T200A_HUMAN	transmembrane protein 200A	381						integral to membrane				NS(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(30)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		CCAGAAGACAGTTTGGGTCCA	0.522000													19	35					2.35188e-11	2.5826e-11	1	1	0
LPPR1	54886	broad.mit.edu	37	9	104048468	104048468	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:104048468G>C	ENST00000374874.3	+	4	774	c.335G>C	c.(334-336)gGa>gCa	p.G112A	LPPR1_ENST00000395056.2_Missense_Mutation_p.G112A	NM_207299.1	NP_997182.1	Q8TBJ4	LPPR1_HUMAN		112						integral to membrane	catalytic activity										ATTCTGACCGGAGAATGCTGT	0.373000													15	53					0	0	1	0	0
POTEH	23784	broad.mit.edu	37	22	16287675	16287675	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr22:16287675A>G	ENST00000343518.6	-	1	262	c.211T>C	c.(211-213)Tgg>Cgg	p.W71R		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	71										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						CCCCTGCACCAGGGGAAGCAG	0.582000													53	140					0	0	1	0	0
RELL1	768211	broad.mit.edu	37	4	37687844	37687844	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr4:37687844C>T	ENST00000454158.2	-	1	154	c.66G>A	c.(64-66)gtG>gtA	p.V22V	RELL1_ENST00000314117.4_Silent_p.V22V	NM_001085400.1	NP_001078869.1	Q8IUW5	RELL1_HUMAN	RELT-like 1	22						cytoplasm|integral to membrane|microtubule cytoskeleton|plasma membrane				endometrium(1)|large_intestine(3)|lung(1)|skin(1)	6						GCGGCGAACTCACGGCGCCTC	0.761000													3	8					0	0	1	0	0
KCNAB2	8514	broad.mit.edu	37	1	6156774	6156774	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:6156774A>G	ENST00000164247.1	+	14	1447	c.883A>G	c.(883-885)Atc>Gtc	p.I295V	KCNAB2_ENST00000458166.2_Missense_Mutation_p.I228V|KCNAB2_ENST00000378087.3_Intron|KCNAB2_ENST00000352527.1_Missense_Mutation_p.I281V|KCNAB2_ENST00000602612.1_Missense_Mutation_p.I295V|KCNAB2_ENST00000378083.3_Missense_Mutation_p.I343V|KCNAB2_ENST00000378092.1_Missense_Mutation_p.I281V|KCNAB2_ENST00000378111.1_Intron|KCNAB2_ENST00000341524.1_Missense_Mutation_p.I295V|KCNAB2_ENST00000378097.1_Missense_Mutation_p.I295V	NM_001199860.1	NP_001186789.1	Q13303	KCAB2_HUMAN	potassium voltage-gated channel, shaker-related subfamily, beta member 2	295						cytoplasm|integral to membrane|juxtaparanode region of axon	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			large_intestine(1)|lung(4)|skin(3)	8	Ovarian(185;0.0634)	all_cancers(23;5.85e-39)|all_epithelial(116;4.88e-22)|all_lung(118;4.21e-08)|Lung NSC(185;9.77e-07)|all_hematologic(16;2.78e-06)|all_neural(13;3.18e-06)|Acute lymphoblastic leukemia(12;0.000272)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00106)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0393)|Medulloblastoma(700;0.211)		Epithelial(90;6.9e-37)|GBM - Glioblastoma multiforme(13;8.8e-31)|OV - Ovarian serous cystadenocarcinoma(86;1.45e-19)|Colorectal(212;2.46e-07)|COAD - Colon adenocarcinoma(227;2.07e-05)|Kidney(185;7.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00131)|BRCA - Breast invasive adenocarcinoma(365;0.00133)|STAD - Stomach adenocarcinoma(132;0.00391)|READ - Rectum adenocarcinoma(331;0.0649)		GCTGCAGGCCATCGCCGAGCG	0.692000													5	7					0	0	1	0	0
SLCO2A1	6578	broad.mit.edu	37	3	133698434	133698434	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:133698434T>A	ENST00000310926.4	-	2	398	c.125A>T	c.(124-126)cAg>cTg	p.Q42L	SLCO2A1_ENST00000478651.1_5'UTR|SLCO2A1_ENST00000493729.1_Missense_Mutation_p.Q42L	NM_005630.2	NP_005621.2	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family, member 2A1	42					sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(2)	30						TTGGCAGAGCTGCAGGAGGCC	0.587000													27	74					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45811248	45811248	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr21:45811248G>A	ENST00000397928.1	+	11	1979	c.1534G>A	c.(1534-1536)Gag>Aag	p.E512K	TRPM2_ENST00000300481.9_Missense_Mutation_p.E512K|TRPM2_ENST00000397932.2_Missense_Mutation_p.E512K|TRPM2_ENST00000300482.5_Missense_Mutation_p.E512K|TRPM2_ENST00000498430.1_3'UTR	NM_003307.3	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	512						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						GCAGCTGAAGGAGTTTGTCAC	0.567000													33	60					0	0	1	0	0
TCN2	6948	broad.mit.edu	37	22	31010392	31010392	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr22:31010392C>G	ENST00000215838.3	+	4	978	c.484C>G	c.(484-486)Ctg>Gtg	p.L162V	TCN2_ENST00000407817.3_Missense_Mutation_p.L135V|TCN2_ENST00000405742.3_Missense_Mutation_p.L158V			P20062	TCO2_HUMAN	transcobalamin II	162					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular space	cobalamin binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|prostate(2)|urinary_tract(1)	22					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CCTGGGCATTCTGGCCCTGTG	0.577000													29	25					0	0	1	0	0
ZP2	7783	broad.mit.edu	37	16	21211121	21211121	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr16:21211121C>T	ENST00000574002.1	-	16	2255	c.1773G>A	c.(1771-1773)caG>caA	p.Q591Q	AF001550.7_ENST00000572747.1_RNA|ZP2_ENST00000574091.1_Silent_p.Q582Q|ZP2_ENST00000219593.4_Silent_p.Q591Q			Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 (sperm receptor)	591	ZP.				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(16)|ovary(1)|prostate(1)|stomach(1)	41				GBM - Glioblastoma multiforme(48;0.0573)		TGTCAAACCTCTGATAGTGAT	0.502000													22	39					0	0	1	0	0
IRX4	50805	broad.mit.edu	37	5	1879903	1879903	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:1879903G>A	ENST00000505790.1	-	5	907	c.451C>T	c.(451-453)Cgc>Tgc	p.R151C	IRX4_ENST00000231357.2_Missense_Mutation_p.R151C|IRX4_ENST00000505938.1_5'UTR|IRX4_ENST00000513692.1_Missense_Mutation_p.R151C	NM_001278634.1	NP_001265563.1	P78413	IRX4_HUMAN	iroquois homeobox 4	151					heart development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|lung(7)|ovary(1)|prostate(1)	10				GBM - Glioblastoma multiforme(108;0.242)		GTGGTCTCGCGCGTGGCGTTC	0.637000													21	38					0	0	1	0	0
GPR150	285601	broad.mit.edu	37	5	94956089	94956089	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:94956089C>G	ENST00000380007.2	+	1	308	c.110C>G	c.(109-111)tCt>tGt	p.S37C		NM_199243.1	NP_954713.1	Q8NGU9	GP150_HUMAN	G protein-coupled receptor 150	37						integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(2)	2		all_cancers(142;0.000462)|all_epithelial(76;2.44e-06)|all_lung(232;0.0318)|Lung NSC(167;0.041)|Ovarian(225;0.051)		all cancers(79;1.82e-16)		GCCCCTGCCTCTGGGCCGCCC	0.687000													7	5					0	0	1	0	0
VKORC1	79001	broad.mit.edu	37	16	31105701	31105701	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr16:31105701C>G	ENST00000394971.3	-	1	169	c.122G>C	c.(121-123)cGa>cCa	p.R41P	VKORC1_ENST00000394975.2_Intron|VKORC1_ENST00000498155.1_Intron|VKORC1_ENST00000319788.7_Intron|RP11-196G11.1_ENST00000529564.1_Intron|VKORC1_ENST00000354895.4_Intron|VKORC1_ENST00000300851.6_Intron			Q9BQB6	VKOR1_HUMAN	vitamin K epoxide reductase complex, subunit 1	0					peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane	vitamin-K-epoxide reductase (warfarin-sensitive) activity			lung(3)|urinary_tract(1)	4					Acenocoumarol(DB01418)|Dicumarol(DB00266)|Menadione(DB00170)|Phenindione(DB00498)|Phenprocoumon(DB00946)|Warfarin(DB00682)	TCCCTTGCCTCGCACTCTTAT	0.612000													26	47					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124352470	124352470	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:124352470G>T	ENST00000409039.3	+	42	6994	c.6969G>T	c.(6967-6969)atG>atT	p.M2323I		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2323					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TAGCCAAGATGTTGGATGCGT	0.512000													11	14					0.00010058	0.000103258	1	1	0
ITGB4	3691	broad.mit.edu	37	17	73738530	73738530	+	Silent	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:73738530C>G	ENST00000200181.3	+	24	2929	c.2742C>G	c.(2740-2742)ctC>ctG	p.L914L	ITGB4_ENST00000450894.3_Silent_p.L914L|ITGB4_ENST00000449880.2_Silent_p.L914L|ITGB4_ENST00000579662.1_Silent_p.L914L|ITGB4_ENST00000584558.1_3'UTR|ITGB4_ENST00000339591.3_Silent_p.L914L	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	914					cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			TCCACGACCTCAAGGTGGCCC	0.657000													8	14					0	0	1	0	0
TNIK	23043	broad.mit.edu	37	3	170858210	170858210	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:170858210C>T	ENST00000436636.2	-	13	1654	c.1310G>A	c.(1309-1311)aGg>aAg	p.R437K	TNIK_ENST00000460047.1_Missense_Mutation_p.R437K|TNIK_ENST00000488470.1_Missense_Mutation_p.R437K|TNIK_ENST00000284483.8_Missense_Mutation_p.R437K|TNIK_ENST00000470834.1_Missense_Mutation_p.R437K|TNIK_ENST00000357327.5_Missense_Mutation_p.R437K|TNIK_ENST00000538048.1_Missense_Mutation_p.R437K|TNIK_ENST00000369326.5_Missense_Mutation_p.R437K|TNIK_ENST00000341852.6_Missense_Mutation_p.R437K|TNIK_ENST00000475336.1_Missense_Mutation_p.R437K	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	437	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			CGCACGCCTCCTCTCCTCCTC	0.662000													52	108					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152487762	152487762	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:152487762C>T	ENST00000397345.3	-	66	9715	c.9513G>A	c.(9511-9513)ctG>ctA	p.L3171L	NEB_ENST00000604864.1_Silent_p.L3171L|NEB_ENST00000409198.1_Intron|NEB_ENST00000172853.10_Intron|NEB_ENST00000603639.1_Silent_p.L3171L|NEB_ENST00000427231.2_Silent_p.L3171L	NM_001164508.1	NP_001157980	P20929	NEBU_HUMAN	nebulin	3171					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TGTTATCACTCAGTATTTCGG	0.483000													55	48					0	0	1	0	0
MTIF2	4528	broad.mit.edu	37	2	55479634	55479634	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:55479634G>C	ENST00000394600.3	-	9	1556	c.820C>G	c.(820-822)Cag>Gag	p.Q274E	MTIF2_ENST00000403721.1_Missense_Mutation_p.Q274E|MTIF2_ENST00000263629.4_Missense_Mutation_p.Q274E	NM_001005369.1	NP_001005369.1	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	274	G-domain.				regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	24						TTGGCATGCTGAATAGATTCT	0.423000													28	74					0	0	1	0	0
NPAS4	266743	broad.mit.edu	37	11	66191516	66191516	+	Silent	SNP	T	T	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:66191516T>C	ENST00000311034.2	+	7	1331	c.1155T>C	c.(1153-1155)tcT>tcC	p.S385S		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	385					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						GTGTTGTCTCTGCATCAGAAG	0.562000													31	193					0	0	1	0	0
IQCF2	389123	broad.mit.edu	37	3	51895685	51895685	+	Translation_Start_Site	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:51895685G>C	ENST00000333127.3	+	1	32	c.3G>C	c.(1-3)atG>atC	p.M1I	IQCF2_ENST00000429548.1_3'UTR	NM_203424.1	NP_982248.1	Q8IXL9	IQCF2_HUMAN	IQ motif containing F2	1										endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	10				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GACAGGCCATGAGGGTTCGAT	0.483000													18	26					0	0	1	0	0
RASAL1	8437	broad.mit.edu	37	12	113554886	113554886	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:113554886C>T	ENST00000546530.1	-	9	1008	c.723G>A	c.(721-723)gaG>gaA	p.E241E	RASAL1_ENST00000446861.3_Silent_p.E241E|RASAL1_ENST00000418411.2_5'UTR|RASAL1_ENST00000548055.1_Silent_p.E241E|RASAL1_ENST00000261729.5_Silent_p.E241E	NM_001193520.1|NM_004658.2	NP_001180449.1|NP_004649.2	O95294	RASL1_HUMAN	RAS protein activator like 1 (GAP1 like)	241					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(3)|prostate(2)|skin(2)	43						ACCCAGAATCCTCCTCGGCTC	0.607000													6	24					0	0	1	0	0
SLC5A9	200010	broad.mit.edu	37	1	48701486	48701486	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:48701486C>T	ENST00000236495.5	+	11	1352	c.1302C>T	c.(1300-1302)ttC>ttT	p.F434F	SLC5A9_ENST00000420136.2_3'UTR|SLC5A9_ENST00000533824.1_Silent_p.F430F|SLC5A9_ENST00000438567.2_Silent_p.F409F	NM_001135181.1	NP_001128653.1	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 9	409						integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			breast(1)|endometrium(3)|large_intestine(4)|liver(2)|lung(11)|ovary(3)|prostate(1)|urinary_tract(1)	26						GCACCCTGTTCACCATTGATG	0.612000													30	48					0	0	1	0	0
PIGK	10026	broad.mit.edu	37	1	77629564	77629564	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:77629564G>A	ENST00000370812.3	-	6	574	c.551C>T	c.(550-552)gCg>gTg	p.A184V	PIGK_ENST00000359130.1_Missense_Mutation_p.A184V|PIGK_ENST00000478391.1_5'UTR|PIGK_ENST00000445065.1_Missense_Mutation_p.A90V|PIGK_ENST00000370813.5_Missense_Mutation_p.A108V	NM_005482.2	NP_005473.1	Q92643	GPI8_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class K	184					attachment of GPI anchor to protein|C-terminal protein lipidation|protein thiol-disulfide exchange|proteolysis	GPI-anchor transamidase complex	cysteine-type endopeptidase activity|GPI-anchor transamidase activity|protein binding			endometrium(5)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	19						AAAAGCATCCGCGAGTTCTAT	0.308000													15	40					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24921968	24921968	+	Silent	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr15:24921968C>G	ENST00000329468.2	+	1	1428	c.954C>G	c.(952-954)ccC>ccG	p.P318P		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CTGCTCCTCCCAGAGCTGCCC	0.587000													6	50					0	0	1	0	0
FAM13C	220965	broad.mit.edu	37	10	61028376	61028376	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:61028376G>A	ENST00000373867.3	-	9	1095	c.630C>T	c.(628-630)atC>atT	p.I210I	FAM13C_ENST00000435852.2_Silent_p.I293I|FAM13C_ENST00000373868.2_Silent_p.I293I|FAM13C_ENST00000277705.6_Silent_p.I314I|FAM13C_ENST00000419214.2_Silent_p.I293I|FAM13C_ENST00000422313.2_Silent_p.I293I|FAM13C_ENST00000468840.2_Silent_p.I210I|FAM13C_ENST00000442566.3_Silent_p.I314I	NM_001166698.1	NP_001160170.1	Q8NE31	FA13C_HUMAN	family with sequence similarity 13, member C	293										NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						TGAGGCTCTGGATGTGCTTGG	0.498000													11	24					0	0	1	0	0
ZNF606	80095	broad.mit.edu	37	19	58491154	58491154	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:58491154G>A	ENST00000341164.4	-	7	1514	c.894C>T	c.(892-894)ttC>ttT	p.F298F	ZNF606_ENST00000536132.1_Silent_p.F208F	NM_025027.3	NP_079303.2	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	298					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		TTATATGATTGAAAGATTTAA	0.318000													21	49					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118352808	118352808	+	Splice_Site	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:118352808G>A	ENST00000534358.1	+	7	4035		c.e7+1		KMT2A_ENST00000389506.5_Splice_Site|KMT2A_ENST00000354520.4_Splice_Site|KMT2A_ENST00000420751.2_Splice_Site	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		CCAGAATCAGGTGAGTGAGGA	0.463000													10	13					0	0	1	0	0
ZNF7	7553	broad.mit.edu	37	8	146068516	146068516	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:146068516C>G	ENST00000528372.1	+	5	2264	c.2024C>G	c.(2023-2025)tCa>tGa	p.S675*	ZNF7_ENST00000544249.1_Nonsense_Mutation_p.S579*|ZNF7_ENST00000446747.2_Nonsense_Mutation_p.S686*|ZNF7_ENST00000325241.6_Nonsense_Mutation_p.S675*|ZNF7_ENST00000325217.5_Intron|ZNF7_ENST00000525266.1_Intron			P17097	ZNF7_HUMAN	zinc finger protein 7	675					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(7)|lung(6)|ovary(5)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.0812)|Ovarian(118;0.0822)|Acute lymphoblastic leukemia(644;0.143)	Epithelial(56;8.75e-39)|OV - Ovarian serous cystadenocarcinoma(54;1.13e-38)|all cancers(56;8.48e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;2.11e-07)		AATCGTAGCTCAAGGCTTACC	0.358000													62	83					0	0	1	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14851705	14851705	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr18:14851705A>T	ENST00000358984.4	+	36	3585	c.3405A>T	c.(3403-3405)aaA>aaT	p.K1135N		NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1220										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						TGAAACAGAAAACAGTAACAA	0.358000													19	22					0	0	1	0	0
MMACHC	25974	broad.mit.edu	37	1	45966020	45966020	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:45966020G>T	ENST00000401061.4	+	1	296	c.16G>T	c.(16-18)Gca>Tca	p.A6S		NM_015506.2	NP_056321.2	Q9Y4U1	MMAC_HUMAN	methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria	6							cobalamin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	8	Acute lymphoblastic leukemia(166;0.155)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GCCGAAAGTCGCAGAGCTGAA	0.512000													17	131					3.52763e-06	3.69815e-06	1	1	0
CYP2B7P	1556	broad.mit.edu	37	19	41447325	41447325	+	RNA	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:41447325A>G	ENST00000599198.1	+	0	824					NR_001278.1															NS(1)|endometrium(6)|kidney(1)|lung(2)|ovary(1)|skin(1)	12						GAAACCCTGGACCCCAGCGCC	0.537000													19	142					0	0	1	0	0
PPFIBP1	8496	broad.mit.edu	37	12	27787986	27787986	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:27787986T>A	ENST00000318304.8	+	4	491	c.208T>A	c.(208-210)Ttg>Atg	p.L70M	PPFIBP1_ENST00000542629.1_Missense_Mutation_p.L70M|PPFIBP1_ENST00000537927.1_Intron|PPFIBP1_ENST00000228425.6_Missense_Mutation_p.L70M|PPFIBP1_ENST00000545334.1_Missense_Mutation_p.L70M|PPFIBP1_ENST00000535047.1_Missense_Mutation_p.L70M	NM_001198916.1|NM_177444.2	NP_001185845.1|NP_803193	Q86W92	LIPB1_HUMAN	PTPRF interacting protein, binding protein 1 (liprin beta 1)	70					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(13)|prostate(2)|skin(1)	32	Lung SC(9;0.0873)					GAAAGAAGGCTTGAGATGCCA	0.458000													13	64					0	0	1	0	0
NPIPB6	728741	broad.mit.edu	37	16	28354353	28354353	+	Missense_Mutation	SNP	T	T	G	rs1794256	by1000genomes	TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr16:28354353T>G	ENST00000532254.1	-	7	1538	c.853A>C	c.(853-855)Act>Cct	p.T285P	NPIPB6_ENST00000533640.1_Missense_Mutation_p.T267P	NM_001282524.1	NP_001269453.1			nuclear pore complex interacting protein family, member B6									p.T285P(4)									AGACACTCAGTAGGTGTCTTG	0.507000													6	49					0	0	1	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36278140	36278140	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:36278140G>A	ENST00000007510.4	+	21	2817	c.2673G>A	c.(2671-2673)ccG>ccA	p.P891P	ARHGAP33_ENST00000378944.5_Silent_p.P755P|ARHGAP33_ENST00000314737.5_Silent_p.P730P			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	891	Poly-Pro.				cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						CCCCACCCCCGCCCCCTAAGA	0.657000													41	17					0	0	1	0	0
LOC441666	441666	broad.mit.edu	37	10	42832385	42832385	+	RNA	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:42832385C>G	ENST00000609841.1	-	0	1518					NR_024380.1																						TTGCCACATTCTTCACATTTG	0.378000													4	7					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143039032	143039032	+	Silent	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:143039032G>T	ENST00000343257.2	+	15	1680	c.1593G>T	c.(1591-1593)gcG>gcT	p.A531A		NM_000083.2	NP_000074	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	531					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					GAGCAGCAGCGCTGACTGGTG	0.507000													10	35					0.0581538	0.0583218	1	1	0
ACACB	32	broad.mit.edu	37	12	109654448	109654448	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:109654448A>G	ENST00000338432.7	+	23	3495	c.3376A>G	c.(3376-3378)Atg>Gtg	p.M1126V	ACACB_ENST00000377854.5_Intron|ACACB_ENST00000377848.3_Missense_Mutation_p.M1126V			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	1126					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	CCGCGGCTATATGAAAACAGT	0.473000													10	32					0	0	1	0	0
CNTNAP3	79937	broad.mit.edu	37	9	39109271	39109271	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:39109271T>C	ENST00000297668.6	-	15	2324	c.2251A>G	c.(2251-2253)Ata>Gta	p.I751V	CNTNAP3_ENST00000377656.2_Missense_Mutation_p.I750V|CNTNAP3_ENST00000358144.2_Missense_Mutation_p.I663V	NM_033655.3	NP_387504.2	Q9BZ76	CNTP3_HUMAN	contactin associated protein-like 3	751	Fibrinogen C-terminal.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	24				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GAAAGGACTATTGTGTCACTA	0.433000													11	8					0	0	1	0	0
RFX3	5991	broad.mit.edu	37	9	3263030	3263030	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:3263030G>A	ENST00000382004.3	-	14	1821	c.1510C>T	c.(1510-1512)Cac>Tac	p.H504Y	RFX3_ENST00000358730.2_Missense_Mutation_p.H504Y|RFX3_ENST00000302303.1_Missense_Mutation_p.H504Y	NM_001282116.1|NM_134428.1	NP_001269045.1|NP_602304.1	P48380	RFX3_HUMAN	regulatory factor X, 3 (influences HLA class II expression)	504					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(11)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		TGGGCCAGGTGATTAAGCGAC	0.493000													42	38					0	0	1	0	0
LMBRD2	92255	broad.mit.edu	37	5	36143342	36143342	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:36143342C>G	ENST00000296603.4	-	2	572	c.110G>C	c.(109-111)gGa>gCa	p.G37A		NM_001007527.1	NP_001007528.1	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	37						integral to membrane				breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AAGCAGTGTTCCAATAATCAC	0.363000													16	44					0	0	1	0	0
SAMHD1	25939	broad.mit.edu	37	20	35547851	35547851	+	Silent	SNP	T	T	C	rs140804613	byFrequency	TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr20:35547851T>C	ENST00000262878.4	-	7	967	c.768A>G	c.(766-768)caA>caG	p.Q256Q	SAMHD1_ENST00000373694.5_Silent_p.Q41Q	NM_015474.3	NP_056289.2	Q9Y3Z3	SAMH1_HUMAN	SAM domain and HD domain 1	256	HD.				defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	20		Myeloproliferative disorder(115;0.00878)				TGAGACCATATTGTTCCATGA	0.358000													13	41					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577559	7577559	+	Missense_Mutation	SNP	G	G	A	rs28934573		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:7577559G>A	ENST00000420246.2	-	7	854	c.722C>T	c.(721-723)tCc>tTc	p.S241F	TP53_ENST00000445888.2_Missense_Mutation_p.S241F|TP53_ENST00000269305.4_Missense_Mutation_p.S241F|TP53_ENST00000413465.2_Missense_Mutation_p.S241F|TP53_ENST00000359597.4_Missense_Mutation_p.S241F|TP53_ENST00000455263.2_Missense_Mutation_p.S241F	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	241	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		S -> A (in sporadic cancers; somatic mutation).|S -> C (in sporadic cancers; somatic mutation).|S -> F (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934573).|S -> P (in sporadic cancers; somatic mutation).|S -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).|S -> Y (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.S241F(85)|p.S241C(26)|p.0?(8)|p.S241Y(8)|p.C242fs*5(6)|p.?(5)|p.S241del(5)|p.S148F(4)|p.N239_C242delNSSC(3)|p.N239_C242>S(1)|p.C238fs*21(1)|p.S241fs*22(1)|p.N239_C242del(1)|p.Y236_M243delYMCNSSCM(1)|p.S241_G245delSCMGG(1)|p.S148C(1)|p.N239fs*4(1)|p.C238_M246delCNSSCMGGM(1)|p.H233_C242del10(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCCATGCAGGAACTGTTACA	0.572000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			13	21					0	0	1	0	0
CNTN1	1272	broad.mit.edu	37	12	41421762	41421762	+	Silent	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:41421762G>T	ENST00000551295.2	+	22	2931	c.2814G>T	c.(2812-2814)acG>acT	p.T938T	CNTN1_ENST00000347616.1_Silent_p.T938T|CNTN1_ENST00000348761.2_Silent_p.T927T	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	938	Fibronectin type-III 4.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				CTACAGTGACGGGATATAAGG	0.378000													16	37					1.5739e-10	1.71743e-10	1	1	0
TTN	7273	broad.mit.edu	37	2	179448568	179448568	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:179448568G>C	ENST00000589042.1	-	312	65565	c.65341C>G	c.(65341-65343)Cca>Gca	p.P21781A	TTN_ENST00000342175.6_Missense_Mutation_p.P12908A|TTN_ENST00000591111.1_Missense_Mutation_p.P20140A|TTN_ENST00000342992.6_Missense_Mutation_p.P19213A|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.P12716A|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.P12841A|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	20140	Ig-like 114.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCATGCTTTGGACGAGCCCAG	0.428000													6	10					0	0	1	0	0
CACNG2	10369	broad.mit.edu	37	22	37098579	37098579	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr22:37098579C>T	ENST00000300105.6	-	1	1024	c.43G>A	c.(43-45)Gtt>Att	p.V15I		NM_006078.3	NP_006069.1	Q9Y698	CCG2_HUMAN	calcium channel, voltage-dependent, gamma subunit 2	15					membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	18						AAAGCACCAACGGTGGTTAAA	0.478000													57	60					0	0	1	0	0
RGS3	5998	broad.mit.edu	37	9	116346235	116346235	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:116346235C>T	ENST00000374140.2	+	21	2752	c.2543C>T	c.(2542-2544)gCg>gTg	p.A848V	RGS3_ENST00000394646.3_Intron|RGS3_ENST00000342620.5_Intron|RGS3_ENST00000462143.1_Missense_Mutation_p.A169V|RP11-168K11.2_ENST00000428429.1_RNA|RGS3_ENST00000350696.5_Missense_Mutation_p.A848V|RGS3_ENST00000374134.3_Missense_Mutation_p.A169V|RGS3_ENST00000343817.5_Missense_Mutation_p.A567V	NM_001282923.1|NM_144488.4	NP_001269852.1|NP_652759.3	P49796	RGS3_HUMAN	regulator of G-protein signaling 3	848					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			cervix(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	48						GACCCACCTGCGGCCCCCAGG	0.642000													41	49					0	0	1	0	0
SYT4	6860	broad.mit.edu	37	18	40851713	40851713	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr18:40851713G>C	ENST00000255224.3	-	3	1302	c.934C>G	c.(934-936)Cga>Gga	p.R312G	SYT4_ENST00000586678.1_Intron|SYT4_ENST00000590752.1_Missense_Mutation_p.R294G	NM_020783.3	NP_065834.1	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	312	C2 2.					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44						GGCAGATGTCGAGCTTTTAAG	0.413000													12	65					0	0	1	0	0
COPG1	22820	broad.mit.edu	37	3	128979195	128979195	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:128979195C>T	ENST00000314797.6	+	11	995	c.891C>T	c.(889-891)agC>agT	p.S297S		NM_016128.3	NP_057212.1	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	297					COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity										TTTTCTGCAGCTCACCCAAGG	0.562000													21	101					0	0	1	0	0
ICT1	3396	broad.mit.edu	37	17	73016618	73016618	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:73016618C>G	ENST00000301585.5	+	5	415	c.402C>G	c.(400-402)atC>atG	p.I134M		NM_001545.1	NP_001536.1	Q14197	ICT1_HUMAN	immature colon carcinoma transcript 1	134					mitochondrial translational termination	mitochondrial large ribosomal subunit	aminoacyl-tRNA hydrolase activity|translation release factor activity, codon nonspecific			NS(1)|central_nervous_system(1)|lung(2)|ovary(1)|urinary_tract(1)	6	all_lung(278;0.226)					GAGAGTTGATCCTCACCTCTG	0.468000													10	61					0	0	1	0	0
OVGP1	5016	broad.mit.edu	37	1	111957832	111957832	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:111957832C>A	ENST00000369732.3	-	11	1346	c.1291G>T	c.(1291-1293)Ggg>Tgg	p.G431W		NM_002557.3	NP_002548.3	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1, 120kDa	431					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	39		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		TCAGTGACCCCAGCCTCTCCT	0.498000													15	77					2.23348e-06	2.35568e-06	1	1	0
FUT8	2530	broad.mit.edu	37	14	66136117	66136117	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr14:66136117A>G	ENST00000360689.5	+	7	2481	c.754A>G	c.(754-756)Act>Gct	p.T252A	FUT8_ENST00000557164.1_Missense_Mutation_p.T89A|FUT8_ENST00000394586.2_Missense_Mutation_p.T252A|FUT8_ENST00000358307.2_Missense_Mutation_p.T123A|FUT8_ENST00000554765.1_3'UTR|FUT8_ENST00000394585.1_Missense_Mutation_p.T252A	NM_004480.4|NM_178155.2	NP_004471.4|NP_835368.1	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 (alpha (1,6) fucosyltransferase)	252					in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	22				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		GCGCTATGCTACTGGTGGATG	0.502000													10	48					0	0	1	0	0
NKTR	4820	broad.mit.edu	37	3	42678832	42678832	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr3:42678832C>G	ENST00000232978.8	+	13	1824	c.1636C>G	c.(1636-1638)Cga>Gga	p.R546G	RP4-613B23.1_ENST00000445452.1_RNA|RP4-613B23.1_ENST00000438017.1_RNA|RP4-613B23.1_ENST00000434363.1_RNA	NM_005385.3	NP_005376.2	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	546	Arg/Ser-rich.				protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	41				KIRC - Kidney renal clear cell carcinoma(284;0.24)		ATCACATTCTCGAAGTAGATC	0.418000													39	117					0	0	1	0	0
GPR17	2840	broad.mit.edu	37	2	128408390	128408390	+	Silent	SNP	G	G	A	rs145234598		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:128408390G>A	ENST00000544369.1	+	4	776	c.165G>A	c.(163-165)acG>acA	p.T55T	LIMS2_ENST00000409455.1_Intron|GPR17_ENST00000272644.3_Silent_p.T55T|GPR17_ENST00000393018.3_Silent_p.T55T|LIMS2_ENST00000545738.2_Intron|LIMS2_ENST00000410011.1_Intron|LIMS2_ENST00000324938.5_Intron|LIMS2_ENST00000409808.2_Intron|LIMS2_ENST00000355119.4_Intron|GPR17_ENST00000486700.1_3'UTR	NM_001161415.1	NP_001154887.1	Q13304	GPR17_HUMAN	G protein-coupled receptor 17	55						integral to plasma membrane	chemokine receptor activity|purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(11)|prostate(2)|urinary_tract(1)	19	Colorectal(110;0.1)	Ovarian(717;0.15)		BRCA - Breast invasive adenocarcinoma(221;0.0677)		gccaggagacgccactggaga	0.547000											OREG0014966	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	56					0	0	1	0	0
PENK	5179	broad.mit.edu	37	8	57354059	57354059	+	Silent	SNP	G	G	A	rs145346210		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:57354059G>A	ENST00000314922.3	-	2	652	c.576C>T	c.(574-576)ggC>ggT	p.G192G	PENK_ENST00000451791.2_Silent_p.G192G|PENK_ENST00000523274.1_5'UTR	NM_006211.3	NP_006202.1	P01210	PENK_HUMAN	proenkephalin	192					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	21		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			TTCTCTTTAAGCCTCTCATGA	0.527000													60	78					0	0	1	0	0
TIAM2	26230	broad.mit.edu	37	6	155485726	155485726	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:155485726C>T	ENST00000461783.3	+	10	3479	c.2206C>T	c.(2206-2208)Cat>Tat	p.H736Y	TIAM2_ENST00000456144.1_Missense_Mutation_p.H736Y|TIAM2_ENST00000360366.4_Missense_Mutation_p.H736Y|TIAM2_ENST00000456877.2_Missense_Mutation_p.H48Y|TIAM2_ENST00000528391.2_Missense_Mutation_p.H48Y|TIAM2_ENST00000529824.2_Missense_Mutation_p.H736Y|TIAM2_ENST00000367174.2_Missense_Mutation_p.H88Y|TIAM2_ENST00000318981.5_Missense_Mutation_p.H736Y			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	736					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		TTCCTCTTTCCATGCTCTGGT	0.597000													23	117					0	0	1	0	0
SLC45A1	50651	broad.mit.edu	37	1	8385897	8385897	+	Silent	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:8385897G>T	ENST00000471889.1	+	4	895	c.510G>T	c.(508-510)tcG>tcT	p.S170S	SLC45A1_ENST00000289877.8_Silent_p.S170S|SLC45A1_ENST00000377479.2_Silent_p.S204S			Q9Y2W3	S45A1_HUMAN	solute carrier family 45, member 1	170					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(2)	33	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		TGGGCCTCTCGCTCTTGCTGA	0.597000													14	60					7.93312e-07	8.44415e-07	1	1	0
SLC35G3	146861	broad.mit.edu	37	17	33520951	33520951	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:33520951G>A	ENST00000297307.5	-	1	461	c.376C>T	c.(376-378)Ccc>Tcc	p.P126S		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	126	DUF6 1.					integral to membrane											TTGCCAGCGGGCACCACCTGA	0.607000													93	156					0	0	1	0	0
MAN2A1	4124	broad.mit.edu	37	5	109152978	109152978	+	Missense_Mutation	SNP	C	C	T	rs142458296		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:109152978C>T	ENST00000261483.4	+	13	3000	c.1948C>T	c.(1948-1950)Ctt>Ttt	p.L650F		NM_002372.2	NP_002363.2	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	650					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		TTGCAGGTACCTTGTGGTCTA	0.363000													11	81					0	0	1	0	0
MAP1LC3A	84557	broad.mit.edu	37	20	33147573	33147573	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr20:33147573C>T	ENST00000360668.3	+	4	998	c.237C>T	c.(235-237)ttC>ttT	p.F79F	MAP1LC3A_ENST00000476428.1_3'UTR|MAP1LC3A_ENST00000397709.1_Silent_p.F79F|MAP1LC3A_ENST00000374837.3_Silent_p.F83F			Q9H492	MLP3A_HUMAN	microtubule-associated protein 1 light chain 3 alpha	79					autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|cytosol|endomembrane system|microtubule	phosphatidylethanolamine binding|protein binding			cervix(1)|kidney(1)|large_intestine(1)|upper_aerodigestive_tract(2)	5						CGCAGGCCTTCTTCCTGCTGG	0.632000													26	69					0	0	1	0	0
GCNT2	2651	broad.mit.edu	37	6	10626656	10626656	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:10626656A>G	ENST00000379597.3	+	3	1581	c.1025A>G	c.(1024-1026)tAt>tGt	p.Y342C	GCNT2_ENST00000265012.4_Missense_Mutation_p.Y342C|GCNT2_ENST00000316170.3_Missense_Mutation_p.Y340C|GCNT2_ENST00000410107.1_Missense_Mutation_p.Y56C|GCNT2_ENST00000397423.2_3'UTR|GCNT2_ENST00000495262.1_Missense_Mutation_p.Y342C			Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	342						Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)	12	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		GCAGGCCACTATGTACATGGT	0.398000													17	167					0	0	1	0	0
SUPT7L	9913	broad.mit.edu	37	2	27876591	27876591	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:27876591G>C	ENST00000337768.5	-	6	1575	c.1006C>G	c.(1006-1008)Ctt>Gtt	p.L336V	SUPT7L_ENST00000406540.1_Missense_Mutation_p.L334V|SUPT7L_ENST00000405491.1_Missense_Mutation_p.L334V|SUPT7L_ENST00000464789.2_Missense_Mutation_p.L334V|SUPT7L_ENST00000404798.2_Missense_Mutation_p.L201V	NM_001282729.1|NM_014860.1	NP_001269658.1|NP_055675.1	O94864	ST65G_HUMAN	suppressor of Ty 7 (S. cerevisiae)-like	336					histone H3 acetylation|maintenance of protein location in nucleus|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|prostate(2)|skin(2)|urinary_tract(1)	16	Acute lymphoblastic leukemia(172;0.155)					AGATTCCAAAGAGGAGAAGCA	0.448000													39	93					0	0	1	0	0
N4BP2L2	10443	broad.mit.edu	37	13	33018121	33018121	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr13:33018121C>G	ENST00000357505.6	-	7	612	c.508G>C	c.(508-510)Gat>Cat	p.D170H	N4BP2L2_ENST00000380121.3_5'UTR|N4BP2L2_ENST00000446957.2_Intron|N4BP2L2_ENST00000504114.1_Missense_Mutation_p.D170H|N4BP2L2_ENST00000399396.3_Missense_Mutation_p.D185H	NM_001278432.1	NP_001265361.1	Q92802	N42L2_HUMAN	NEDD4 binding protein 2-like 2	179										kidney(4)|large_intestine(3)|liver(1)|lung(6)|skin(1)|urinary_tract(1)	16		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		GGGTCCTGATCTCCCGGTGTA	0.383000													4	9					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216237060	216237060	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:216237060G>C	ENST00000354785.4	-	40	6655	c.6286C>G	c.(6286-6288)Ctt>Gtt	p.L2096V	FN1_ENST00000336916.4_Missense_Mutation_p.L2005V|FN1_ENST00000359671.1_Missense_Mutation_p.L2005V|FN1_ENST00000346544.3_Intron|FN1_ENST00000357009.2_Intron|FN1_ENST00000323926.6_Missense_Mutation_p.L2096V|FN1_ENST00000345488.5_Intron|FN1_ENST00000421182.1_Intron|FN1_ENST00000356005.4_Missense_Mutation_p.L1915V|FN1_ENST00000432072.2_Intron|FN1_ENST00000357867.4_Intron|FN1_ENST00000446046.1_Intron|FN1_ENST00000443816.1_Missense_Mutation_p.L1915V			P02751	FINC_HUMAN	fibronectin 1	2005	Connecting strand 3 (CS-3) (V region).				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGTCCATGAAGATTGGGGTGT	0.502000													34	29					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78321834	78321834	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr17:78321834C>T	ENST00000582970.1	+	29	9842	c.9699C>T	c.(9697-9699)gtC>gtT	p.V3233V	RNF213_ENST00000336301.6_Silent_p.V1306V|RNF213_ENST00000508628.2_Silent_p.V3282V	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TGCTGCAGGTCATAGAGAGGC	0.582000													21	66					0	0	1	0	0
MGAT4A	11320	broad.mit.edu	37	2	99294910	99294910	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:99294910T>A	ENST00000264968.3	-	2	482	c.119A>T	c.(118-120)gAa>gTa	p.E40V	MGAT4A_ENST00000409391.1_Missense_Mutation_p.E40V|MGAT4A_ENST00000393487.1_Missense_Mutation_p.E40V			Q9UM21	MGT4A_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A						N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|stomach(1)	19						AGCAAGGAATTCTCGTTGATA	0.338000													18	85					0	0	1	0	0
UVRAG	7405	broad.mit.edu	37	11	75852128	75852128	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:75852128G>A	ENST00000356136.3	+	15	2012	c.1771G>A	c.(1771-1773)Ggg>Agg	p.G591R	UVRAG_ENST00000539288.1_Missense_Mutation_p.G219R|UVRAG_ENST00000528420.1_Missense_Mutation_p.G490R|UVRAG_ENST00000531818.1_Missense_Mutation_p.G219R|UVRAG_ENST00000532130.1_Missense_Mutation_p.G219R|UVRAG_ENST00000538870.1_Missense_Mutation_p.G147R|UVRAG_ENST00000533454.1_Missense_Mutation_p.G219R	NM_003369.3	NP_003360.2	Q9P2Y5	UVRAG_HUMAN	UV radiation resistance associated	591					DNA repair|positive regulation of autophagy	early endosome|late endosome|lysosome	protein binding			central_nervous_system(1)|cervix(3)|endometrium(3)|kidney(1)|large_intestine(2)|lung(15)|skin(5)|urinary_tract(2)	32						AGCCCTCTCCGGGCACCGGGC	0.577000													9	28					0	0	1	0	0
NPAS4	266743	broad.mit.edu	37	11	66190264	66190264	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:66190264G>T	ENST00000311034.2	+	4	726	c.550G>T	c.(550-552)Gga>Tga	p.G184*		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	184					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						CTACTGGGCAGGAAATCCCGT	0.622000													25	97					2.98393e-07	3.19575e-07	1	1	0
PCSK6	5046	broad.mit.edu	37	15	101938656	101938656	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr15:101938656C>A	ENST00000348070.1	-	8	945	c.946G>T	c.(946-948)Ggg>Tgg	p.G316W	PCSK6_ENST00000358417.3_Missense_Mutation_p.G316W|PCSK6_ENST00000398181.2_Missense_Mutation_p.G316W|PCSK6_ENST00000331826.7_Missense_Mutation_p.G151W|PCSK6_ENST00000344273.2_Missense_Mutation_p.G316W|PCSK6_ENST00000561177.1_5'UTR	NM_002570.3|NM_138320.1	NP_002561.1|NP_612193.1	P29122	PCSK6_HUMAN	proprotein convertase subtilisin/kexin type 6	317	Catalytic.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CGGCCGGGCCCGTCCACCGTC	0.582000													15	111					6.94344e-10	7.5293e-10	1	1	0
SIVA1	10572	broad.mit.edu	37	14	105222038	105222038	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr14:105222038G>A	ENST00000329967.6	+	2	292	c.190G>A	c.(190-192)Gtc>Atc	p.V64I	SIVA1_ENST00000347067.5_Intron	NM_006427.3	NP_006418.2	O15304	SIVA_HUMAN	SIVA1, apoptosis-inducing factor	64					activation of caspase activity by cytochrome c|activation-induced cell death of T cells|apoptosis|induction of apoptosis|interspecies interaction between organisms|negative regulation of anti-apoptosis|negative regulation of NF-kappaB transcription factor activity	cytoplasm|mitochondrion|nucleoplasm|nucleus	caspase activator activity|CD27 receptor binding|metal ion binding|viral receptor activity|zinc ion binding			large_intestine(1)|lung(1)|prostate(1)	3		all_cancers(154;0.14)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.173)		AGGCTGTGCCGTCGTTCACCT	0.627000													10	51					0	0	1	0	0
ILF3	3609	broad.mit.edu	37	19	10798322	10798322	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:10798322C>T	ENST00000449870.1	+	18	2689	c.2372C>T	c.(2371-2373)tCg>tTg	p.S791L	ILF3_ENST00000590261.1_Missense_Mutation_p.S787L|ILF3_ENST00000588657.1_Missense_Mutation_p.S791L|ILF3_ENST00000318511.3_Missense_Mutation_p.S787L|ILF3_ENST00000586544.1_3'UTR	NM_017620.2	NP_060090.2	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3, 90kDa	787	Interaction with PRMT1.				M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			TACTCCTACTCGAACTCCTAC	0.597000													21	14					0	0	1	0	0
GLIS3	169792	broad.mit.edu	37	9	4118290	4118290	+	Silent	SNP	T	T	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:4118290T>C	ENST00000324333.10	-	3	916	c.723A>G	c.(721-723)caA>caG	p.Q241Q	GLIS3_ENST00000381971.3_Silent_p.Q396Q	NM_152629.3	NP_689842.3	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3	241					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(12)|lung(4)|ovary(2)|prostate(1)|skin(1)	26		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		GCTCCAGCTGTTGCATGCGCT	0.731000													3	1					0	0	1	0	0
SLC2A1	6513	broad.mit.edu	37	1	43395395	43395395	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:43395395C>T	ENST00000426263.3	-	6	914	c.736G>A	c.(736-738)Gaa>Aaa	p.E246K	SLC2A1_ENST00000475162.1_Intron|SLC2A1_ENST00000415851.2_Intron	NM_006516.2	NP_006507.2	P11166	GTR1_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 1	246					carbohydrate metabolic process|energy reserve metabolic process|regulation of insulin secretion|water-soluble vitamin metabolic process	integral to membrane|melanosome|membrane fraction|midbody	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|pancreas(2)	13	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0122)			Etomidate(DB00292)	CGACTCTCTTCCTTCATCTCC	0.622000													61	122					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	69005891	69005891	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:69005891C>T	ENST00000288368.4	+	21	2579	c.2302C>T	c.(2302-2304)Ctt>Ttt	p.L768F	PREX2_ENST00000529398.1_3'UTR|RP11-403D15.2_ENST00000526901.1_RNA	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	768					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity	p.L768I(1)		NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						TCAAGAAGACCTTCAAAAATC	0.408000													18	141					0	0	1	0	0
ZC3H7A	29066	broad.mit.edu	37	16	11850213	11850213	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr16:11850213C>T	ENST00000396516.2	-	20	2639	c.2442G>A	c.(2440-2442)gaG>gaA	p.E814E	ZC3H7A_ENST00000575984.1_Silent_p.E10E|ZC3H7A_ENST00000355758.4_Silent_p.E814E			Q8IWR0	Z3H7A_HUMAN	zinc finger CCCH-type containing 7A	814						nucleus	nucleic acid binding|zinc ion binding			breast(2)|endometrium(3)|kidney(5)|large_intestine(2)|liver(1)|lung(3)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(2)	25						CGTAAAATTGCTCCATATCTT	0.338000													14	35					0	0	1	0	0
RGS22	26166	broad.mit.edu	37	8	101074973	101074973	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:101074973C>T	ENST00000360863.6	-	9	1554	c.1360G>A	c.(1360-1362)Gag>Aag	p.E454K	RGS22_ENST00000523287.1_Missense_Mutation_p.E273K|RGS22_ENST00000523437.1_Missense_Mutation_p.E442K	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	454					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TTCATCTTCTCAAGATGTCTG	0.313000													5	92					0	0	1	0	0
KDM6A	7403	broad.mit.edu	37	X	44870231	44870231	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chrX:44870231G>T	ENST00000377967.4	+	5	451	c.410G>T	c.(409-411)gGt>gTt	p.G137V	KDM6A_ENST00000536777.1_Missense_Mutation_p.G137V|KDM6A_ENST00000382899.4_Missense_Mutation_p.G137V|KDM6A_ENST00000543216.1_Missense_Mutation_p.G137V	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	137					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0(12)|p.0?(6)|p.?(1)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						TATGGTCTTGGTTTGGTCTAC	0.299000			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								6	6					5.18039e-06	5.39819e-06	1	1	0
BRD9	65980	broad.mit.edu	37	5	887497	887497	+	Silent	SNP	T	T	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:887497T>A	ENST00000323510.4	-	3	347	c.348A>T	c.(346-348)gcA>gcT	p.A116A	BRD9_ENST00000467963.1_Silent_p.A232A|BRD9_ENST00000435709.2_Silent_p.A116A|BRD9_ENST00000483173.1_Silent_p.A179A|BRD9_ENST00000388890.4_Silent_p.A116A			Q9H8M2	BRD9_HUMAN	bromodomain containing 9	232							nucleic acid binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|pancreas(1)|prostate(3)	29			Epithelial(17;0.00202)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00815)|Lung(60;0.185)			TCTTAAAGCCTGCGTGAAGGA	0.498000													23	130					0	0	1	0	0
SEMA3D	223117	broad.mit.edu	37	7	84628906	84628906	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:84628906G>A	ENST00000284136.6	-	17	2227	c.2184C>T	c.(2182-2184)gaC>gaT	p.D728D	SEMA3D_ENST00000484038.1_5'UTR	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	728					cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						CGCAGTACTGGTCGAGGCTGA	0.502000													17	64					0	0	1	0	0
NTS	4922	broad.mit.edu	37	12	86272172	86272172	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:86272172G>T	ENST00000256010.6	+	3	292	c.185G>T	c.(184-186)tGc>tTc	p.C62F	NTS_ENST00000551529.1_Intron	NM_006183.4	NP_006174.1	P30990	NEUT_HUMAN	neurotensin	62					regulation of blood vessel size|signal transduction	extracellular region|soluble fraction|transport vesicle	neuropeptide hormone activity			large_intestine(2)|lung(6)	8						CTAAATGTTTGCAGTCTTGTA	0.383000													21	107					1.50039e-11	1.65281e-11	1	1	0
DST	667	broad.mit.edu	37	6	56464869	56464869	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:56464869C>A	ENST00000370754.5	-	45	11598	c.11599G>T	c.(11599-11601)Gag>Tag	p.E3867*	DST_ENST00000312431.6_Nonsense_Mutation_p.E3687*|DST_ENST00000421834.2_Nonsense_Mutation_p.E1601*|DST_ENST00000370788.2_Nonsense_Mutation_p.E1601*|DST_ENST00000370769.4_Nonsense_Mutation_p.E3689*|DST_ENST00000446842.2_Nonsense_Mutation_p.E3363*|DST_ENST00000361203.3_Nonsense_Mutation_p.E3687*|DST_ENST00000244364.6_Nonsense_Mutation_p.E1275*			Q03001	DYST_HUMAN	dystonin	3687					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AATTCTACCTCTTGCTTGGAC	0.358000													9	65					2.17888e-05	2.24353e-05	1	1	0
C10orf76	79591	broad.mit.edu	37	10	103649229	103649229	+	Silent	SNP	A	A	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:103649229A>G	ENST00000370033.4	-	24	1919	c.1800T>C	c.(1798-1800)ttT>ttC	p.F600F	C10orf76_ENST00000495001.1_5'UTR	NM_024541.2	NP_078817.2	Q5T2E6	CJ076_HUMAN	chromosome 10 open reading frame 76	600						integral to membrane				autonomic_ganglia(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(7)|prostate(2)|upper_aerodigestive_tract(2)	24		Colorectal(252;0.123)		Epithelial(162;2.41e-08)|all cancers(201;6.41e-07)		TTTTGGGGTTAAAGTGGTTGA	0.428000													51	180					0	0	1	0	0
EMB	133418	broad.mit.edu	37	5	49695706	49695706	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:49695706C>T	ENST00000303221.5	-	8	1168	c.953G>A	c.(952-954)aGg>aAg	p.R318K	EMB_ENST00000514111.1_Missense_Mutation_p.R268K|EMB_ENST00000508934.1_Missense_Mutation_p.R264K	NM_198449.2	NP_940851.1	Q6PCB8	EMB_HUMAN	embigin	318						integral to membrane				breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	15	Lung SC(58;0.218)	Lung NSC(810;0.0795)				TTTTCTATGCCTGGGGACATT	0.269000													7	44					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85382285	85382285	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr15:85382285G>A	ENST00000258888.5	+	4	1152	c.985G>A	c.(985-987)Gag>Aag	p.E329K		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	329	Ig-like 1.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GCCAAAATATGAGATCACTCA	0.572000													12	10					0	0	1	0	0
SLC3A1	6519	broad.mit.edu	37	2	44528286	44528286	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:44528286C>T	ENST00000410056.3	+	6	1156	c.1156C>T	c.(1156-1158)Ctc>Ttc	p.L386F	SLC3A1_ENST00000409229.3_Intron|SLC3A1_ENST00000409387.1_Intron|SLC3A1_ENST00000409294.1_Intron|SLC3A1_ENST00000260649.6_Intron|SLC3A1_ENST00000409380.1_Intron|SLC3A1_ENST00000409741.1_Intron			Q07837	SLC31_HUMAN	solute carrier family 3 (amino acid transporter heavy chain), member 1	0					carbohydrate metabolic process|cellular amino acid metabolic process|ion transport	integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity|catalytic activity|cation binding|L-cystine transmembrane transporter activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(1)|skin(3)	26		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)			L-Cystine(DB00138)	GGCATATGCTCTCATTTCTTC	0.502000													9	23					0	0	1	0	0
DPEP2	64174	broad.mit.edu	37	16	68021779	68021779	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr16:68021779C>T	ENST00000412757.2	-	11	1847	c.1182G>A	c.(1180-1182)ctG>ctA	p.L394L	DPEP2_ENST00000572888.1_Silent_p.L394L|DPEP2_ENST00000393847.1_Silent_p.L394L			Q9H4A9	DPEP2_HUMAN	dipeptidase 2	394					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|proteolysis	anchored to membrane|plasma membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(10)|skin(2)|upper_aerodigestive_tract(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0489)|all cancers(182;0.239)		TGAAGACCCGCAGCAGGTTTC	0.567000													30	186					0	0	1	0	0
ANXA8L1	728113	broad.mit.edu	37	10	47158846	47158846	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr10:47158846G>A	ENST00000359178.4	-	12	1096	c.975C>T	c.(973-975)agC>agT	p.S325S	ANXA8L1_ENST00000358140.4_Silent_p.S274S|ANXA8L1_ENST00000414655.2_Silent_p.S263S|ANXA8L1_ENST00000545298.1_3'UTR	NM_001098845.1	NP_001092315	Q5T2P8	AXA81_HUMAN	annexin A8-like 1	325							calcium ion binding|calcium-dependent phospholipid binding			large_intestine(1)|lung(1)	2						CTCAGGGGTCGCTGCCCACCA	0.607000													3	8					0	0	1	0	0
RGS22	26166	broad.mit.edu	37	8	101074892	101074892	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:101074892C>G	ENST00000360863.6	-	9	1635	c.1441G>C	c.(1441-1443)Gat>Cat	p.D481H	RGS22_ENST00000523287.1_Missense_Mutation_p.D300H|RGS22_ENST00000523437.1_Missense_Mutation_p.D469H	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	481					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TGTGATCCATCTAACAGTTTA	0.308000													5	115					0	0	1	0	0
ZNF548	147694	broad.mit.edu	37	19	57908460	57908460	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:57908460G>T	ENST00000366197.5	+	2	310	c.60G>T	c.(58-60)gaG>gaT	p.E20D	ZNF548_ENST00000597400.1_Missense_Mutation_p.E32D|AC003002.4_ENST00000597658.1_Intron|ZNF548_ENST00000598895.1_Missense_Mutation_p.E32D|AC003002.6_ENST00000596400.1_Intron|AC003002.6_ENST00000600421.1_3'UTR|AC004076.7_ENST00000597410.1_Intron|ZNF548_ENST00000336128.7_Missense_Mutation_p.E32D	NM_152909.3	NP_690873.2	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	20	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCTCCCAGGAGGAGTGGGGGC	0.488000													96	171					1.15966e-41	1.32369e-41	1	1	0
MAPKBP1	23005	broad.mit.edu	37	15	42113042	42113042	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr15:42113042G>A	ENST00000457542.2	+	23	2780	c.2494G>A	c.(2494-2496)Gtg>Atg	p.V832M	MAPKBP1_ENST00000260357.7_Missense_Mutation_p.V671M|MAPKBP1_ENST00000456763.2_Missense_Mutation_p.V838M|MAPKBP1_ENST00000221214.6_Missense_Mutation_p.V715M|MAPKBP1_ENST00000514566.1_Missense_Mutation_p.V832M	NM_014994.2	NP_055809.2	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein 1	838										breast(6)|central_nervous_system(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		ACAGGAGTCCGTGGGGTTCCT	0.567000													6	13					0	0	1	0	0
TAF4B	6875	broad.mit.edu	37	18	23854694	23854694	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr18:23854694T>A	ENST00000269142.5	+	4	1663	c.665T>A	c.(664-666)cTg>cAg	p.L222Q	TAF4B_ENST00000578121.1_Missense_Mutation_p.L222Q|TAF4B_ENST00000400466.2_Missense_Mutation_p.L222Q	NM_005640.1	NP_005631.1	Q92750	TAF4B_HUMAN	TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa	222					transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleolus|transcription factor TFIID complex	DNA binding|NF-kappaB binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(13)|prostate(1)|skin(1)	29	all_cancers(21;0.00151)|Lung NSC(5;0.000401)|all_lung(6;0.00115)|Ovarian(20;0.124)		Epithelial(2;9.57e-07)|all cancers(3;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(3;1.96e-05)|LUSC - Lung squamous cell carcinoma(2;0.00594)|Lung(2;0.0267)			GTAACTACCCTGAAGCCTTCA	0.428000													16	101					0	0	1	0	0
FUT2	2524	broad.mit.edu	37	19	49206253	49206253	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:49206253C>A	ENST00000425340.2	+	2	157	c.40C>A	c.(40-42)Cac>Aac	p.H14N	FUT2_ENST00000391876.4_Missense_Mutation_p.H14N	NM_000511.5|NM_001097638.2	NP_000502.4|NP_001091107.1	Q10981	FUT2_HUMAN	fucosyltransferase 2 (secretor status included)	14					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	galactoside 2-alpha-L-fucosyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(2)	7		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.00011)|all cancers(93;0.000238)|GBM - Glioblastoma multiforme(486;0.0164)|Epithelial(262;0.017)		TCCCATGGCCCACTTCATCCT	0.547000													61	184					1.1362e-29	1.29266e-29	1	1	0
CLDN8	9073	broad.mit.edu	37	21	31587705	31587705	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr21:31587705G>T	ENST00000399899.1	-	1	686	c.539C>A	c.(538-540)gCt>gAt	p.A180D	CLDN8_ENST00000286809.1_Missense_Mutation_p.A180D	NM_199328.2	NP_955360.1	P56748	CLD8_HUMAN	claudin 8	180					calcium-independent cell-cell adhesion	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity			NS(1)|endometrium(2)|large_intestine(6)|lung(6)	15						GCAGAACAGAGCTCCTCCAAC	0.453000													4	65					0.00909568	0.009175	1	1	0
KRBA1	84626	broad.mit.edu	37	7	149421876	149421876	+	Silent	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr7:149421876C>G	ENST00000255992.10	+	9	1461	c.1062C>G	c.(1060-1062)ctC>ctG	p.L354L	KRBA1_ENST00000319551.8_Silent_p.L354L|KRBA1_ENST00000485033.2_Silent_p.L354L|KRBA1_ENST00000479560.1_3'UTR	NM_032534.2	NP_115923.2	A5PL33	KRBA1_HUMAN	KRAB-A domain containing 1	354										breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(17)|ovary(1)|prostate(1)	27	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGCAGCCCCTCAGTCCCTCAG	0.642000													4	7					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220326632	220326632	+	Silent	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:220326632C>G	ENST00000312358.7	+	7	2601	c.2469C>G	c.(2467-2469)ccC>ccG	p.P823P	SPEG_ENST00000485813.1_3'UTR|SPEG_ENST00000396698.1_Silent_p.P719P|SPEG_ENST00000396686.1_5'UTR|SPEG_ENST00000396689.2_5'UTR|SPEG_ENST00000396695.2_Silent_p.P31P|SPEG_ENST00000396688.1_5'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	823					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		TCAGCAGCCCCATCACCTCCG	0.627000													36	46					0	0	1	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735793	55735793	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:55735793G>A	ENST00000312345.2	-	1	197	c.147C>T	c.(145-147)ccC>ccT	p.P49P		NM_001005491.1	NP_001005491.1	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG, member 1	49					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(24)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	40	Esophageal squamous(21;0.0137)					AAAAATACATGGGAGTCTGGA	0.333000													48	54					0	0	1	0	0
RIPK4	54101	broad.mit.edu	37	21	43161747	43161747	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr21:43161747C>T	ENST00000352483.2	-	9	1814	c.1750G>A	c.(1750-1752)Gag>Aag	p.E584K	RIPK4_ENST00000332512.3_Missense_Mutation_p.E536K|RIPK4_ENST00000544709.1_Missense_Mutation_p.E473K|RIPK4_ENST00000542057.1_Missense_Mutation_p.E473K			Q96T11	Q96T11_HUMAN	receptor-interacting serine-threonine kinase 4	536						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						GTCCGGCCCTCAAAGTCCACC	0.647000													17	47					0	0	1	0	0
ZNF805	390980	broad.mit.edu	37	19	57764890	57764890	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:57764890G>A	ENST00000535550.1	+	4	800	c.304G>A	c.(304-306)Gag>Aag	p.E102K	ZNF805_ENST00000414468.2_Missense_Mutation_p.E235K|ZNF805_ENST00000354309.4_Missense_Mutation_p.E102K	NM_001145078.1	NP_001138550.1	Q5CZA5	ZN805_HUMAN	zinc finger protein 805	235					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|lung(1)|stomach(1)	9						TGAATGCACAGAGTGTGGAAA	0.458000													3	18					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154396083	154396083	+	Silent	SNP	G	G	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr5:154396083G>T	ENST00000435029.4	+	1	2824	c.2664G>T	c.(2662-2664)ctG>ctT	p.L888L		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	888	Interaction with PRC1 (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AAAACAGCCTGAGACAGAGCA	0.438000													20	34					4.35082e-09	4.68861e-09	1	1	0
PPP3R1	5534	broad.mit.edu	37	2	68408096	68408096	+	Nonstop_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr2:68408096C>G	ENST00000234310.3	-	6	915	c.512G>C	c.(511-513)tGa>tCa	p.*171S	RP11-474G23.1_ENST00000406334.3_Intron|PPP3R1_ENST00000409752.1_Nonstop_Mutation_p.*190S|PPP3R1_ENST00000409377.1_Nonstop_Mutation_p.*161S	NM_000945.3	NP_000936.1	P63098	CANB1_HUMAN	protein phosphatase 3, regulatory subunit B, alpha	0					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals	calcineurin complex|cytosol	calcium ion binding|calcium-dependent protein serine/threonine phosphatase activity|calmodulin binding			large_intestine(1)	1					Pimecrolimus(DB00337)	TGATAAGAGTCACACATCTAC	0.433000													5	23					0	0	1	0	0
OR4K17	390436	broad.mit.edu	37	14	20586060	20586060	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr14:20586060C>T	ENST00000315543.4	+	1	495	c.495C>T	c.(493-495)acC>acT	p.T165T		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	137					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		ACTACATGACCATCATGAACA	0.453000													11	95					0	0	1	0	0
ORC1	4998	broad.mit.edu	37	1	52861995	52861995	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:52861995C>T	ENST00000371568.3	-	5	662	c.444G>A	c.(442-444)ctG>ctA	p.L148L	ORC1_ENST00000371566.1_Silent_p.L148L	NM_001190818.1|NM_001190819.1|NM_004153.3	NP_001177747.1|NP_001177748.1|NP_004144.2	Q13415	ORC1_HUMAN	origin recognition complex, subunit 1	148	BAH.				cell cycle checkpoint|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nuclear origin of replication recognition complex|nucleolus|nucleoplasm|plasma membrane	ATP binding|DNA binding|nucleoside-triphosphatase activity|protein binding			breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						TCTCATTTTTCAGATTCGTCG	0.418000													63	77					0	0	1	0	0
TMEM14C	51522	broad.mit.edu	37	6	10726149	10726149	+	Missense_Mutation	SNP	C	C	T	rs146638335		TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr6:10726149C>T	ENST00000541412.1	+	4	492	c.107C>T	c.(106-108)cCg>cTg	p.P36L	TMEM14C_ENST00000229563.5_Missense_Mutation_p.P36L|TMEM14C_ENST00000467415.1_3'UTR	NM_001165258.1	NP_001158730.1	Q9P0S9	TM14C_HUMAN	transmembrane protein 14C	36					heme biosynthetic process	integral to membrane|mitochondrial membrane				large_intestine(2)|lung(3)	5	Ovarian(93;0.107)|Breast(50;0.137)	all_hematologic(90;0.135)	Epithelial(50;0.246)			GGCAGCGTGCCGTCCCTGGCT	0.547000													11	178					0	0	1	0	0
DEDD	9191	broad.mit.edu	37	1	161094073	161094073	+	Silent	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:161094073G>A	ENST00000392188.1	-	3	414	c.180C>T	c.(178-180)ctC>ctT	p.L60L	DEDD_ENST00000458050.2_Silent_p.L60L|NIT1_ENST00000368008.1_3'UTR|DEDD_ENST00000545495.1_Silent_p.L60L|DEDD_ENST00000368005.1_Silent_p.L60L|DEDD_ENST00000490843.2_Silent_p.L60L|DEDD_ENST00000489249.1_Intron|DEDD_ENST00000368006.3_Silent_p.L60L			O75618	DEDD_HUMAN	death effector domain containing	60	DED.				apoptosis|induction of apoptosis via death domain receptors|negative regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			cervix(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(2)|skin(1)	10	all_cancers(52;3.39e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			CATTTCGGATGAGTCCACGCT	0.527000													64	29					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80626769	80626769	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:80626769G>A	ENST00000458043.2	+	8	688	c.682G>A	c.(682-684)Ggg>Agg	p.G228R	OTOGL_ENST00000547103.1_Missense_Mutation_p.G228R	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						GGCTTGGGACGGGATATCTGG	0.398000													14	24					0	0	1	0	0
SSTR5	6755	broad.mit.edu	37	16	1129228	1129228	+	Silent	SNP	C	C	T	rs35742768	byFrequency	TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr16:1129228C>T	ENST00000293897.4	+	1	448	c.360C>T	c.(358-360)ggC>ggT	p.G120G	SSTR5_ENST00000562758.1_Silent_p.G120G|SSTR5_ENST00000397547.2_Silent_p.G120G	NM_001053.3	NP_001044.1	P35346	SSR5_HUMAN	somatostatin receptor 5	120					negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			endometrium(2)|lung(5)|prostate(1)|skin(1)	9		Hepatocellular(780;0.00369)			Octreotide(DB00104)	CGCTGGACGGCGTCAACCAGT	0.677000													4	38					0	0	1	0	0
HERC2P3	283755	broad.mit.edu	37	15	20588458	20588458	+	RNA	SNP	G	G	C	rs2291971	by1000genomes	TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr15:20588458G>C	ENST00000428453.1	-	0	4292																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						TGCTGGCCATGACTGCAGTGC	0.458000													4	17					0	0	1	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73066945	73066945	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:73066945G>A	ENST00000263674.3	+	5	3960	c.3610G>A	c.(3610-3612)Gac>Aac	p.D1204N		NM_014786.3	NP_055601.2	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1204	DH.				actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(2)	32						GGCGCTGTCTGACCTCATGAT	0.567000													28	99					0	0	1	0	0
JPH1	56704	broad.mit.edu	37	8	75156998	75156998	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:75156998C>T	ENST00000342232.4	-	4	1711	c.1671G>A	c.(1669-1671)ctG>ctA	p.L557L	JPH1_ENST00000518195.1_5'UTR	NM_020647.2	NP_065698.1	Q9HDC5	JPH1_HUMAN	junctophilin 1	557					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	24	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			GGGGGGCGTTCAGCTTCACGT	0.602000													18	97					0	0	1	0	0
EYA1	2138	broad.mit.edu	37	8	72211939	72211939	+	Silent	SNP	T	T	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:72211939T>A	ENST00000340726.3	-	8	1212	c.573A>T	c.(571-573)acA>acT	p.T191T	EYA1_ENST00000388742.4_Silent_p.T191T|EYA1_ENST00000419131.1_Silent_p.T186T|EYA1_ENST00000388743.2_Silent_p.T190T|EYA1_ENST00000303824.7_Silent_p.T185T|EYA1_ENST00000388741.2_Silent_p.T157T|EYA1_ENST00000388740.3_Silent_p.T158T	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	191					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			TTCCTGATGATGTTGTAAAAC	0.318000													13	91					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46244661	46244661	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr12:46244661C>G	ENST00000334344.6	+	15	2927	c.2755C>G	c.(2755-2757)Cag>Gag	p.Q919E	ARID2_ENST00000444670.1_Missense_Mutation_p.Q529E|ARID2_ENST00000422737.1_Missense_Mutation_p.Q770E|ARID2_ENST00000479608.1_3'UTR	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	919	Gln-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TCAACAACCACAGCAGCCAAC	0.473000			"""N, S, F"""		hepatocellular carcinoma								17	123					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109817341	109817341	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr13:109817341G>A	ENST00000356711.2	+	33	5317	c.5191G>A	c.(5191-5193)Gga>Aga	p.G1731R	MYO16_ENST00000357550.2_Missense_Mutation_p.G1731R|MYO16-AS1_ENST00000439299.1_RNA	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	1731					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			AAATAACCATGGAATTCAGTT	0.338000													5	69					0	0	1	0	0
GALNTL6	442117	broad.mit.edu	37	4	173150860	173150860	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr4:173150860G>C	ENST00000506823.1	+	3	849	c.192G>C	c.(190-192)ttG>ttC	p.L64F	GALNTL6_ENST00000508122.1_Missense_Mutation_p.L47F	NM_001034845.2	NP_001030017.2	Q49A17	GLTL6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	64						Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(2)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	45						CAGATGGTTTGAGAAGAAAGG	0.443000													7	23					0	0	1	0	0
CRX	1406	broad.mit.edu	37	19	48342712	48342712	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:48342712G>A	ENST00000221996.7	+	4	594	c.388G>A	c.(388-390)Gat>Aat	p.D130N	CRX_ENST00000539067.1_Missense_Mutation_p.D130N|TPRX2P_ENST00000535362.1_Intron	NM_000554.4	NP_000545.1	O43186	CRX_HUMAN	cone-rod homeobox	130					organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|urinary_tract(1)	23		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		ACCCTCCACAGATGTGTGTCC	0.667000													37	81					0	0	1	0	0
ZNF486	90649	broad.mit.edu	37	19	20308312	20308312	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:20308312C>A	ENST00000335117.8	+	4	850	c.793C>A	c.(793-795)Ccc>Acc	p.P265T	CTC-260E6.6_ENST00000585498.1_RNA|CTC-260E6.6_ENST00000593655.1_RNA|CTC-260E6.6_ENST00000586657.1_RNA	NM_052852.3	NP_443084.2	Q96H40	ZN486_HUMAN	zinc finger protein 486	265					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	11						TGGAGAGAAACCCTACATTTG	0.368000													7	31					0.00198382	0.00202466	1	1	0
GALE	2582	broad.mit.edu	37	1	24124667	24124667	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:24124667C>T	ENST00000374497.3	-	5	382	c.291G>A	c.(289-291)tcG>tcA	p.S97S		NM_000403.3|NM_001008216.1|NM_001127621.1	NP_000394.2|NP_001008217.1|NP_001121093.1	Q14376	GALE_HUMAN	UDP-galactose-4-epimerase	97					galactose catabolic process	cytosol	coenzyme binding|protein homodimerization activity|UDP-glucose 4-epimerase activity			endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(2)	8		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;1.79e-24)|Colorectal(126;4.8e-08)|COAD - Colon adenocarcinoma(152;2.83e-06)|GBM - Glioblastoma multiforme(114;4.22e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0827)|LUSC - Lung squamous cell carcinoma(448;0.184)		GCTTCTGCACCGACTCGCCCA	0.562000													5	96					0	0	1	0	0
PLEKHG5	57449	broad.mit.edu	37	1	6529488	6529488	+	Silent	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:6529488C>T	ENST00000377748.1	-	19	2684	c.2187G>A	c.(2185-2187)ctG>ctA	p.L729L	PLEKHG5_ENST00000377740.3_Silent_p.L729L|PLEKHG5_ENST00000400913.1_Silent_p.L652L|PLEKHG5_ENST00000340850.5_Silent_p.L652L|PLEKHG5_ENST00000400915.3_Silent_p.L708L|PLEKHG5_ENST00000377728.3_Silent_p.L652L|PLEKHG5_ENST00000544978.1_Silent_p.L652L|PLEKHG5_ENST00000377737.2_Silent_p.L652L|PLEKHG5_ENST00000535355.1_Silent_p.L721L|PLEKHG5_ENST00000377732.1_Silent_p.L689L|PLEKHG5_ENST00000537245.1_Silent_p.L731L|PLEKHG5_ENST00000377725.1_Silent_p.L652L	NM_198681.3	NP_941374.2	O94827	PKHG5_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 5	708	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		GAAACTCATTCAGGTAGATAA	0.592000													39	140					0	0	1	0	0
AASDH	132949	broad.mit.edu	37	4	57221444	57221444	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr4:57221444T>C	ENST00000205214.6	-	6	1187	c.1007A>G	c.(1006-1008)aAt>aGt	p.N336S	AASDH_ENST00000502617.1_Missense_Mutation_p.N336S|AASDH_ENST00000434343.2_5'UTR|AASDH_ENST00000602986.1_Missense_Mutation_p.N183S|AASDH_ENST00000451613.1_Missense_Mutation_p.N336S|AASDH_ENST00000513376.1_Missense_Mutation_p.N236S	NM_181806.2	NP_861522.2	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	336					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			endometrium(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	40	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				TTGTGTTTTATTGCCTTCTCC	0.403000													31	139					0	0	1	0	0
APOA2	336	broad.mit.edu	37	1	161193191	161193191	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:161193191T>C	ENST00000464492.1	-	2	138	c.100A>G	c.(100-102)Atg>Gtg	p.M34V	APOA2_ENST00000470459.2_Start_Codon_SNP_p.M1V|APOA2_ENST00000463812.1_Intron|APOA2_ENST00000468465.1_5'UTR|APOA2_ENST00000491350.1_Start_Codon_SNP_p.M1V|APOA2_ENST00000367990.3_Start_Codon_SNP_p.M1V			P02652	APOA2_HUMAN	apolipoprotein A-II						cholesterol efflux|cholesterol homeostasis|diacylglycerol catabolic process|high-density lipoprotein particle assembly|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|interspecies interaction between organisms|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol import|negative regulation of cholesterol transporter activity|negative regulation of cytokine secretion involved in immune response|negative regulation of lipase activity|negative regulation of lipid catabolic process|negative regulation of very-low-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|phospholipid catabolic process|phospholipid efflux|positive regulation of cholesterol esterification|positive regulation of interleukin-8 biosynthetic process|positive regulation of lipid catabolic process|protein folding|regulation of protein stability|response to glucose stimulus|reverse cholesterol transport|triglyceride metabolic process|triglyceride-rich lipoprotein particle remodeling	chylomicron|endoplasmic reticulum lumen|spherical high-density lipoprotein particle|very-low-density lipoprotein particle	apolipoprotein receptor binding|cholesterol binding|high-density lipoprotein particle receptor binding|lipase inhibitor activity|phosphatidylcholine binding|phosphatidylcholine-sterol O-acyltransferase activator activity|protein heterodimerization activity|protein homodimerization activity			endometrium(1)|large_intestine(1)|lung(2)|skin(2)	6	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			AGCAGCTTCATGTTGGTAACA	0.582000													8	40					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71500193	71500193	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr4:71500193C>A	ENST00000396073.3	+	6	660	c.379C>A	c.(379-381)Cag>Aag	p.Q127K		NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	127					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			GAAACCCAACCAGACTCAGTC	0.522000													10	23					1.40151e-16	1.57386e-16	1	1	0
BICD2	23299	broad.mit.edu	37	9	95481333	95481333	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr9:95481333C>T	ENST00000356884.6	-	5	1661	c.1594G>A	c.(1594-1596)Gag>Aag	p.E532K	BICD2_ENST00000375512.3_Missense_Mutation_p.E532K	NM_001003800.1	NP_001003800.1	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 (Drosophila)	532					microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			cervix(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23						GCCAGCTCCTCACTGAAGGTC	0.632000													28	28					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3160668	3160668	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:3160668delG	ENST00000378398.3	+	3	487	c.405delG	c.(403-405)gtgfs	p.V135fs	PRDM16_ENST00000270722.5_Frame_Shift_Del_p.V135fs|PRDM16_ENST00000378391.2_Frame_Shift_Del_p.V135fs|PRDM16_ENST00000442529.2_Frame_Shift_Del_p.V135fs|PRDM16_ENST00000511072.1_Frame_Shift_Del_p.V135fs|PRDM16_ENST00000441472.2_Frame_Shift_Del_p.V135fs|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000514189.1_Frame_Shift_Del_p.V135fs			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	135	SET.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		TGACGGACGTGGAAGTGTCGC	0.557			T	EVI1	"""MDS, AML"""								23	67	---	---	---	---					
NOS1AP	9722	broad.mit.edu	37	1	162326888	162326890	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr1:162326888_162326890delCAG	ENST00000361897.5	+	8	1303_1305	c.901_903delCAG	c.(901-903)cagdel	p.Q306del	NOS1AP_ENST00000530878.1_In_Frame_Del_p.Q301del	NM_001164757.1|NM_014697.2	NP_001158229.1|NP_055512.1	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor protein	306	Poly-Gln.				regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|skin(1)|upper_aerodigestive_tract(2)	32	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			gcagctcctccagcagcAGCAGC	0.611													9	227	---	---	---	---					
MROH5	389690	broad.mit.edu	37	8	142459777	142459778	+	RNA	INS	-	-	A	rs144781370	by1000genomes	TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr8:142459777_142459778insA	ENST00000430863.1	-	0	2629_2630					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		GCAGACAGGCCAGCAGTGTGGT	0.678													8	2	---	---	---	---					
OR51I2	390064	broad.mit.edu	37	11	5475260	5475261	+	Frame_Shift_Ins	INS	-	-	C			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:5475260_5475261insC	ENST00000341449.2	+	1	623_624	c.542_543insC	c.(541-546)cacccafs	p.HP181fs	HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron|HBG2_ENST00000380259.2_Intron|AC104389.28_ENST00000415970.1_RNA	NM_001004754.2	NP_001004754.1	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I, member 2	181					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TACTGCCTGCACCCAGACATGA	0.460													34	41	---	---	---	---					
PPP6R3	55291	broad.mit.edu	37	11	68331787	68331788	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr11:68331787_68331788insA	ENST00000393799.2	+	9	1129_1130	c.862_863insA	c.(862-864)gagfs	p.E288fs	PPP6R3_ENST00000529710.1_Frame_Shift_Ins_p.E288fs|PPP6R3_ENST00000524904.1_Frame_Shift_Ins_p.E288fs|PPP6R3_ENST00000265636.5_Frame_Shift_Ins_p.E288fs|PPP6R3_ENST00000265637.4_Frame_Shift_Ins_p.E288fs|PPP6R3_ENST00000393801.3_Frame_Shift_Ins_p.E288fs|PPP6R3_ENST00000524845.1_Frame_Shift_Ins_p.E288fs|PPP6R3_ENST00000527403.2_Frame_Shift_Ins_p.E288fs|PPP6R3_ENST00000393800.2_Frame_Shift_Ins_p.E288fs|PPP6R3_ENST00000534534.1_Intron			Q5H9R7	PP6R3_HUMAN	protein phosphatase 6, regulatory subunit 3	288					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(10)|liver(2)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						AGGCCATATAGAGATCTGCCCA	0.376													55	94	---	---	---	---					
SIAH1	6477	broad.mit.edu	37	16	48399335	48399336	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr16:48399335_48399336insA	ENST00000356721.3	-	1	476_477	c.53_54insT	c.(52-54)ttcfs	p.F18fs	SIAH1_ENST00000573005.1_5'UTR|SIAH1_ENST00000394725.2_Intron	NM_001006610.1	NP_001006611.1	Q8IUQ4	SIAH1_HUMAN	siah E3 ubiquitin protein ligase 1	0					axon guidance|cell cycle|neuron apoptosis|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	beta-catenin destruction complex|cytosol|nucleus	protein C-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|large_intestine(2)|lung(1)|ovary(1)|stomach(1)	7		all_cancers(37;0.157)|all_lung(18;0.11)|Breast(268;0.238)				GTAAACATGTGAACAAGACTCC	0.485													12	17	---	---	---	---					
ZNF317	57693	broad.mit.edu	37	19	9272093	9272093	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr19:9272093delG	ENST00000247956.6	+	7	2077	c.1772delG	c.(1771-1773)tggfs	p.W591fs	ZNF317_ENST00000360385.3_Frame_Shift_Del_p.W559fs	NM_020933.4	NP_065984.3	Q96PQ6	ZN317_HUMAN	zinc finger protein 317	591					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(3)	27						TCATCCGTGTGGAAAAGGCTC	0.557													17	28	---	---	---	---					
SPATA2	9825	broad.mit.edu	37	20	48522186	48522187	+	Frame_Shift_Del	DEL	GG	GG	-			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr20:48522186_48522187delGG	ENST00000422556.1	-	3	1881_1882	c.1532_1533delCC	c.(1531-1533)tccfs	p.S511fs	SPATA2_ENST00000543716.1_Frame_Shift_Del_p.S374fs|SPATA2_ENST00000289431.5_Frame_Shift_Del_p.S511fs	NM_001135773.1	NP_001129245.1	Q9UM82	SPAT2_HUMAN	spermatogenesis associated 2	511					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus				central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(1)	20	Hepatocellular(150;0.133)		BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			AGAGCTGGGTGGACTTGTAGTT	0.540													10	100	---	---	---	---					
EIF4ENIF1	56478	broad.mit.edu	37	22	31884623	31884623	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chr22:31884623delG	ENST00000397525.1	-	2	305	c.82delC	c.(82-84)catfs	p.H28fs	EIF4ENIF1_ENST00000330125.5_Frame_Shift_Del_p.H28fs|EIF4ENIF1_ENST00000397523.1_Frame_Shift_Del_p.H28fs|EIF4ENIF1_ENST00000344710.5_Frame_Shift_Del_p.H28fs	NM_001164501.1	NP_001157973.1	Q9NRA8	4ET_HUMAN	eukaryotic translation initiation factor 4E nuclear import factor 1	28						nucleus	protein binding|protein transporter activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						GTATAGCGATGGGGGCATTTG	0.413													33	21	---	---	---	---					
MAP3K15	389840	broad.mit.edu	37	X	19390910	19390910	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FD-A3SJ-01A-12D-A22Z-08	TCGA-FD-A3SJ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e6c1352a-5aef-4cde-abf0-be423ff182ca	73723653-3c35-4915-9c0a-3298a6251202	g.chrX:19390910delC	ENST00000338883.4	-	22	2968	c.2969delG	c.(2968-2970)ggcfs	p.G990fs	MAP3K15_ENST00000469203.2_Frame_Shift_Del_p.G822fs|MAP3K15_ENST00000518578.1_5'UTR|MAP3K15_ENST00000359173.3_Frame_Shift_Del_p.G425fs	NM_001001671.3	NP_001001671.3	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase 15	990							ATP binding|MAP kinase kinase kinase activity|metal ion binding			NS(2)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(13)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	Hepatocellular(33;0.183)					CGAGGCCAAGCCCCGGTCTTC	0.612													20	37	---	---	---	---					
