Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CPNE6	9362	broad.mit.edu	37	14	24546221	24546221	+	Splice_Site	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr14:24546221G>A	ENST00000397016.2	+	15	1610	c.1299G>A	c.(1297-1299)acG>acA	p.T433T	CPNE6_ENST00000537691.1_Splice_Site_p.T488T|CPNE6_ENST00000216775.2_Splice_Site_p.T433T	NM_001280558.1	NP_001267487.1	O95741	CPNE6_HUMAN	copine VI (neuronal)	433	VWFA.				lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			endometrium(4)|large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	22				GBM - Glioblastoma multiforme(265;0.0184)		GCCAAGCCACGGTAGGAAGAC	0.637000													5	12					0	0	1	0	0
MYO1D	4642	broad.mit.edu	37	17	30986217	30986217	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr17:30986217C>T	ENST00000318217.5	-	17	2565	c.2261G>A	c.(2260-2262)cGa>cAa	p.R754Q	MYO1D_ENST00000394649.4_Missense_Mutation_p.R666Q|MYO1D_ENST00000579584.1_Missense_Mutation_p.R754Q|RP11-220C2.1_ENST00000582272.1_RNA	NM_015194.1	NP_056009.1	O94832	MYO1D_HUMAN	myosin ID	754						myosin complex	actin binding|ATP binding|calmodulin binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(14)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39			BRCA - Breast invasive adenocarcinoma(9;0.0362)			CCCGTAGTCTCGCATGGTCTT	0.532000											OREG0024311	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	94					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70504189	70504189	+	Silent	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:70504189C>T	ENST00000310961.5	+	22	3001	c.2583C>T	c.(2581-2583)acC>acT	p.T861T	LRRC7_ENST00000415775.2_Silent_p.T140T|LRRC7_ENST00000035383.5_Silent_p.T856T			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	856						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						AAGACAGGACCGCTTTTCCTT	0.463000													13	154					0	0	1	0	0
LOC100289333	100289333	broad.mit.edu	37	19	12318282	12318282	+	RNA	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr19:12318282G>A	ENST00000426044.1	+	0	127																											AGGTGATGACGACAACATTCC	0.453000													4	42					0	0	1	0	0
WBP2NL	164684	broad.mit.edu	37	22	42415340	42415340	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr22:42415340G>A	ENST00000328823.9	+	2	119	c.88G>A	c.(88-90)Gag>Aag	p.E30K		NM_152613.2	NP_689826.2	Q6ICG8	WBP2L_HUMAN	WBP2 N-terminal like	30					egg activation|male pronucleus assembly|meiosis	perinuclear theca	WW domain binding			breast(2)|large_intestine(3)|lung(5)|ovary(3)|prostate(1)	14						TCCGAATGTGGAGCTCTCCTT	0.413000													6	75					0	0	1	0	0
BMP4	652	broad.mit.edu	37	14	54417548	54417548	+	Silent	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr14:54417548G>A	ENST00000245451.4	-	4	822	c.429C>T	c.(427-429)aaC>aaT	p.N143N	BMP4_ENST00000417573.1_Silent_p.N143N|BMP4_ENST00000559087.1_Silent_p.N143N|BMP4_ENST00000558984.1_Silent_p.N143N	NM_001202.3	NP_001193.2	P12644	BMP4_HUMAN	bone morphogenetic protein 4	143					activation of MAPKK activity|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|BMP signaling pathway involved in heart induction|BMP signaling pathway involved in nephric duct formation|branching involved in ureteric bud morphogenesis|bronchus development|bud dilation involved in lung branching|cardiac septum development|cartilage development|endocardial cushion development|epithelial cell proliferation involved in lung morphogenesis|intermediate mesodermal cell differentiation|lung alveolus development|lymphoid progenitor cell differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of cell proliferation involved in heart morphogenesis|negative regulation of glomerular mesangial cell proliferation|negative regulation of glomerulus development|negative regulation of immature T cell proliferation in thymus|negative regulation of MAP kinase activity|negative regulation of metanephric comma-shaped body morphogenesis|negative regulation of metanephric S-shaped body morphogenesis|negative regulation of mitosis|negative regulation of myoblast differentiation|negative regulation of phosphorylation|negative regulation of striated muscle tissue development|negative regulation of thymocyte apoptosis|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cardiac muscle fiber development|positive regulation of cartilage development|positive regulation of collagen biosynthetic process|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of kidney development|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|protein localization to nucleus|pulmonary artery endothelial tube morphogenesis|secondary heart field specification|SMAD protein signal transduction|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway|steroid hormone mediated signaling pathway	extracellular space|proteinaceous extracellular matrix	BMP receptor binding|chemoattractant activity|cytokine activity|growth factor activity			breast(1)|endometrium(3)|large_intestine(2)|lung(9)|prostate(3)|urinary_tract(1)	19						TGCTGCTGAGGTTAAAGAGGA	0.527000													16	43					0	0	1	0	0
OR2T10	127069	broad.mit.edu	37	1	248756267	248756267	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:248756267G>A	ENST00000330500.2	-	1	833	c.803C>T	c.(802-804)cCt>cTt	p.P268L		NM_001004693.1	NP_001004693.1	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T, member 10	268					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(17)|skin(3)|upper_aerodigestive_tract(1)	26	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATCTTTCTCAGGAGTTTGGTA	0.438000													10	53					0	0	1	0	0
ZNF615	284370	broad.mit.edu	37	19	52497324	52497324	+	Silent	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr19:52497324C>T	ENST00000602063.1	-	6	1354	c.1005G>A	c.(1003-1005)caG>caA	p.Q335Q	ZNF615_ENST00000391795.3_Silent_p.Q340Q|ZNF615_ENST00000376716.5_Silent_p.Q335Q|ZNF615_ENST00000594083.1_Silent_p.Q346Q|ZNF615_ENST00000598071.1_Silent_p.Q346Q			Q8N8J6	ZN615_HUMAN	zinc finger protein 615	335					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(5)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	42		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		TATGAGTTTTCTGATGTGTAG	0.423000													33	101					0	0	1	0	0
ATP7A	538	broad.mit.edu	37	X	77275742	77275742	+	Splice_Site	SNP	G	G	C	rs150976855		TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chrX:77275742G>C	ENST00000341514.6	+	13	2783	c.2628G>C	c.(2626-2628)ggG>ggC	p.G876G	ATP7A_ENST00000350425.4_Intron|ATP7A_ENST00000343533.5_Splice_Site_p.G798G	NM_000052.5	NP_000043.4	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	876			G -> E (in MNKD).|G -> R (in MNKD).		ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity			breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(26)|pancreas(1)|prostate(1)|urinary_tract(1)	53						TCCATACAGGGGAGGCAATGC	0.393000													10	46					0	0	1	0	0
CRABP1	1381	broad.mit.edu	37	15	78640302	78640302	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr15:78640302A>G	ENST00000299529.6	+	4	502	c.397A>G	c.(397-399)Att>Gtt	p.I133V		NM_004378.2	NP_004369.1	P29762	RABP1_HUMAN	cellular retinoic acid binding protein 1	133	Retinoic acid binding (By similarity).				multicellular organismal development|signal transduction	cytoplasm	retinal binding|retinol binding|transporter activity			breast(1)|lung(4)|skin(1)	6					Alitretinoin(DB00523)|Etretinate(DB00926)	CTGCACCAGAATTTATGTCCG	0.493000													10	63					0	0	1	0	0
DGCR8	54487	broad.mit.edu	37	22	20073753	20073753	+	Silent	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr22:20073753G>A	ENST00000351989.3	+	2	696	c.267G>A	c.(265-267)ccG>ccA	p.P89P	DGCR8_ENST00000407755.1_Silent_p.P89P|DGCR8_ENST00000383024.2_Silent_p.P89P	NM_022720.6	NP_073557.3	Q8WYQ5	DGCR8_HUMAN	DGCR8 microprocessor complex subunit	89	Necessary for interaction with NCL.|Necessary for nuclear localization and retention.				primary miRNA processing	cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding			NS(2)|breast(1)|endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	Colorectal(54;0.0993)					TCATAGACCCGAACTGTAGTG	0.567000													9	66					0	0	1	0	0
COG4	25839	broad.mit.edu	37	16	70516007	70516007	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr16:70516007C>G	ENST00000323786.5	-	16	2013	c.1992G>C	c.(1990-1992)atG>atC	p.M664I		NM_001195139.1|NM_015386.2	NP_001182068.1|NP_056201.2	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	660	D domain.				Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(12)|pancreas(1)|prostate(2)	33		Ovarian(137;0.0694)				TGAACTCTGCCATTTGCTGCT	0.532000													10	55					0	0	1	0	0
SUSD3	203328	broad.mit.edu	37	9	95841805	95841805	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr9:95841805G>A	ENST00000375472.3	+	4	514	c.478G>A	c.(478-480)Gcc>Acc	p.A160T	SUSD3_ENST00000375469.1_Missense_Mutation_p.A147T	NM_145006.2	NP_659443.1	Q96L08	SUSD3_HUMAN	sushi domain containing 3	160						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(2)	13						GACGGTGCAGGCCGCATACCT	0.612000													13	32					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222221	140222221	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr5:140222221G>A	ENST00000531613.1	+	1	1315	c.1315G>A	c.(1315-1317)Gcc>Acc	p.A439T	PCDHA5_ENST00000529619.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA8_ENST00000378123.3_Missense_Mutation_p.A439T|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGGGCCACCGCCAGCTTGTC	0.667000													17	108					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9087678	9087678	+	Silent	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr19:9087678C>T	ENST00000397910.4	-	1	4340	c.4137G>A	c.(4135-4137)ccG>ccA	p.P1379P		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1379	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTTTTGTGGCCGGACTGGTGA	0.458000													6	86					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48694483	48694483	+	Silent	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr3:48694483G>A	ENST00000544264.1	-	2	4327	c.4047C>T	c.(4045-4047)tcC>tcT	p.S1349S	CELSR3_ENST00000164024.4_Silent_p.S1349S			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	1349					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GCAGCTCCTCGGAGCTGAACC	0.682000													5	40					0	0	1	0	0
ITGA7	3679	broad.mit.edu	37	12	56086673	56086673	+	Silent	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr12:56086673G>A	ENST00000257880.7	-	22	3150	c.2931C>T	c.(2929-2931)tcC>tcT	p.S977S	ITGA7_ENST00000257879.6_Silent_p.S933S|ITGA7_ENST00000394230.2_Silent_p.S937S|ITGA7_ENST00000452168.2_Silent_p.S840S|ITGA7_ENST00000553804.1_Silent_p.S937S|ITGA7_ENST00000555728.1_Silent_p.S977S|ITGA7_ENST00000347027.6_Silent_p.S927S|ITGA7_ENST00000394229.2_Silent_p.S933S			Q13683	ITA7_HUMAN	integrin, alpha 7	977					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						CTGGCCACCAGGACATGCTGG	0.642000													4	24					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43817292	43817292	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr15:43817292G>C	ENST00000382031.1	+	5	4366	c.4335G>C	c.(4333-4335)gaG>gaC	p.E1445D	MAP1A_ENST00000399453.1_Missense_Mutation_p.E1207D|MAP1A_ENST00000300231.5_Missense_Mutation_p.E1207D			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1207						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity	p.E1207E(1)		breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CCAGCAAGGAGACCTCCCTGG	0.522000													13	84					0	0	1	0	0
CCR10	2826	broad.mit.edu	37	17	40831910	40831910	+	Silent	SNP	C	C	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr17:40831910C>A	ENST00000591765.1	-	2	1469	c.84G>T	c.(82-84)gtG>gtT	p.V28V	CCR10_ENST00000332438.4_Silent_p.V250V			P46092	CCR10_HUMAN	chemokine (C-C motif) receptor 10	250						integral to plasma membrane				lung(1)|ovary(1)|skin(1)	3		Breast(137;0.000153)		BRCA - Breast invasive adenocarcinoma(366;0.14)		CCACCAGAGCCACCACGACGC	0.731000													3	9					0.004672	0.00475396	1	1	0
LRRFIP1	9208	broad.mit.edu	37	2	238626428	238626428	+	Silent	SNP	A	A	G			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:238626428A>G	ENST00000308482.9	+	4	294	c.225A>G	c.(223-225)aaA>aaG	p.K75K	LRRFIP1_ENST00000392000.4_Intron|LRRFIP1_ENST00000289175.6_Intron|LRRFIP1_ENST00000244815.5_Intron	NM_001137550.1	NP_001131022.1	Q32MZ4	LRRF1_HUMAN	leucine rich repeat (in FLII) interacting protein 1	51					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|cytoskeleton|nucleus	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	29		Breast(86;0.00257)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;9.75e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.01e-10)|Kidney(56;4.85e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.31e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000151)|Lung(119;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0325)|COAD - Colon adenocarcinoma(134;0.228)		TGGATACAAAATGGGGTGACA	0.373000													24	98					0	0	1	0	0
DENND6A	201627	broad.mit.edu	37	3	57658153	57658153	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr3:57658153G>A	ENST00000311128.5	-	2	320	c.250C>T	c.(250-252)Cag>Tag	p.Q84*		NM_152678.2	NP_689891.1			DENN/MADD domain containing 6A																		TTGGAATGCTGAGGATAAATT	0.318000													7	57					0	0	1	0	0
EHBP1L1	254102	broad.mit.edu	37	11	65349830	65349830	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr11:65349830G>T	ENST00000309295.4	+	9	1952	c.1687G>T	c.(1687-1689)Gaa>Taa	p.E563*		NM_001099409.1	NP_001092879.1	Q8N3D4	EH1L1_HUMAN	EH domain binding protein 1-like 1	563	Glu-rich.									central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						CTGGGAGGCAGAAGCTGGGGG	0.612000													3	30					6.4e-05	6.55059e-05	1	1	0
PSD4	23550	broad.mit.edu	37	2	113940254	113940254	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:113940254A>G	ENST00000441564.3	+	2	390	c.221A>G	c.(220-222)cAc>cGc	p.H74R	PSD4_ENST00000465917.1_3'UTR|PSD4_ENST00000245796.6_Missense_Mutation_p.H74R			Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4						regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GAGCTCACACACCTGGGGAGC	0.617000													5	41					0	0	1	0	0
LDHC	3948	broad.mit.edu	37	11	18460094	18460094	+	Silent	SNP	G	G	C			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr11:18460094G>C	ENST00000541669.1	+	6	723	c.612G>C	c.(610-612)gtG>gtC	p.V204V	LDHC_ENST00000546146.1_Silent_p.V146V|LDHC_ENST00000544105.1_Silent_p.V204V|LDHC_ENST00000280704.4_Silent_p.V204V|LDHC_ENST00000537486.1_Intron|LDHC_ENST00000535809.1_Intron|LDHC_ENST00000536880.1_Silent_p.V190V			P07864	LDHC_HUMAN	lactate dehydrogenase C	204					glycolysis	cytoplasm	binding|L-lactate dehydrogenase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24					NADH(DB00157)	GGAGTGGGGTGAATGTTGCTG	0.373000													12	74					0	0	1	0	0
AK9	221264	broad.mit.edu	37	6	109867162	109867162	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr6:109867162C>G	ENST00000424296.2	-	26	3209	c.3133G>C	c.(3133-3135)Gat>Cat	p.D1045H	AK9_ENST00000355283.1_Missense_Mutation_p.D124H|AK9_ENST00000341338.6_Missense_Mutation_p.D124H	NM_001145128.2	NP_001138600.2			adenylate kinase 9																		TTCTCAGAATCTTCCTCAAAT	0.358000													8	88					0	0	1	0	0
TCEB2	6923	broad.mit.edu	37	16	2821480	2821480	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr16:2821480C>A	ENST00000262306.7	-	5	516	c.479G>T	c.(478-480)gGg>gTg	p.G160V	TCEB2_ENST00000409477.1_3'UTR|TCEB2_ENST00000409906.4_3'UTR	NM_207013.2	NP_996896.1	Q15370	ELOB_HUMAN	transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)	0					positive regulation of viral transcription|protein complex assembly|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|nucleoplasm	protein binding			endometrium(2)|prostate(1)	3						TGATTACAGCCCCCAGCGTGG	0.507000													27	62					3.65163e-15	4.09925e-15	1	1	0
PTENP1	11191	broad.mit.edu	37	9	33676347	33676347	+	RNA	SNP	G	G	C			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr9:33676347G>C	ENST00000532280.1	-	0	1150					NR_023917.1																						AAAAGGGTTTGATAAGTTCTA	0.398000													37	77					0	0	1	0	0
TPP2	7174	broad.mit.edu	37	13	103326727	103326727	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr13:103326727G>A	ENST00000376052.3	+	28	3482	c.3466G>A	c.(3466-3468)Gga>Aga	p.G1156R	TPP2_ENST00000376065.4_Missense_Mutation_p.G1143R|TPP2_ENST00000466153.1_3'UTR			P29144	TPP2_HUMAN	tripeptidyl peptidase II	1143					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	52	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GGCTCAAGACGGAGCCATTTC	0.473000													17	62					0	0	1	0	0
ATRNL1	26033	broad.mit.edu	37	10	117228809	117228809	+	Silent	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr10:117228809C>T	ENST00000355044.3	+	24	3750	c.3624C>T	c.(3622-3624)gtC>gtT	p.V1208V	ATRNL1_ENST00000303745.7_Intron|ATRNL1_ENST00000423111.2_Silent_p.V259V	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	1208						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		ATGTGTACGTCAGCAACTTTT	0.294000													9	67					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664141	22664141	+	RNA	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr22:22664141G>A	ENST00000426066.1	+	0	664					NR_027293.1																						AAATTTGAAGGTGCTGTGATT	0.448000													5	82					0	0	1	0	0
STRAP	11171	broad.mit.edu	37	12	16052918	16052918	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr12:16052918G>A	ENST00000419869.2	+	8	1169	c.856G>A	c.(856-858)Gat>Aat	p.D286N	STRAP_ENST00000538352.1_Missense_Mutation_p.D192N|STRAP_ENST00000025399.6_Missense_Mutation_p.D299N	NM_007178.3	NP_009109.3	Q9Y3F4	STRAP_HUMAN	serine/threonine kinase receptor associated protein	286					mRNA processing|RNA splicing	cell junction|mitochondrion|spliceosomal complex	identical protein binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(6)|skin(1)	15		Hepatocellular(102;0.121)				TGGTTCAGAAGATGGAACATT	0.388000													18	82					0	0	1	0	0
HBS1L	10767	broad.mit.edu	37	6	135287557	135287557	+	Missense_Mutation	SNP	T	T	C	rs1139174		TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr6:135287557T>C	ENST00000367837.5	-	17	2159	c.1953A>G	c.(1951-1953)atA>atG	p.I651M	HBS1L_ENST00000527578.1_Missense_Mutation_p.I487M|HBS1L_ENST00000367824.4_Missense_Mutation_p.I487M|HBS1L_ENST00000367826.2_Missense_Mutation_p.I609M|HBS1L_ENST00000415177.2_Missense_Mutation_p.I586M|HBS1L_ENST00000445176.2_Missense_Mutation_p.I375M	NM_001145158.1|NM_006620.3	NP_001138630.1|NP_006611.1	Q9Y450	HBS1L_HUMAN	HBS1-like (S. cerevisiae)	651					signal transduction		GTP binding|GTPase activity|translation elongation factor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	20	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0046)|GBM - Glioblastoma multiforme(68;0.00702)		GCTCAAGAGCTATTGGTCTTT	0.368000													27	85					0	0	1	0	0
CYP20A1	57404	broad.mit.edu	37	2	204144831	204144831	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:204144831C>A	ENST00000356079.4	+	8	968	c.845C>A	c.(844-846)gCa>gAa	p.A282E	CYP20A1_ENST00000461371.1_3'UTR|CYP20A1_ENST00000429815.2_Missense_Mutation_p.A290E	NM_177538.2	NP_803882.1	Q6UW02	CP20A_HUMAN	cytochrome P450, family 20, subfamily A, polypeptide 1	282						integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			cervix(1)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	11						ATAATAACTGCAAAATGTAAG	0.363000													8	20					5.68852e-11	6.26458e-11	1	1	0
LRFN1	57622	broad.mit.edu	37	19	39805227	39805227	+	Silent	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr19:39805227G>A	ENST00000248668.4	-	1	749	c.750C>T	c.(748-750)ggC>ggT	p.G250G		NM_020862.1	NP_065913.1	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III domain containing 1	250						cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GGGGGTTGCCGCCGAAGCTGA	0.697000													3	10					0	0	1	0	0
INPP4B	8821	broad.mit.edu	37	4	143044482	143044482	+	Silent	SNP	C	C	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr4:143044482C>A	ENST00000513000.1	-	21	2413	c.1980G>T	c.(1978-1980)ggG>ggT	p.G660G	INPP4B_ENST00000508116.1_Silent_p.G660G|INPP4B_ENST00000509777.1_Silent_p.G660G|INPP4B_ENST00000262992.4_Silent_p.G660G|INPP4B_ENST00000308502.4_Silent_p.G660G	NM_003866.2	NP_003857.2	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II, 105kDa	660					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(29)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58	all_hematologic(180;0.158)					GTACTATCAACCCCACTGTGT	0.363000													8	85					3.09899e-07	3.26802e-07	1	1	0
DGKG	1608	broad.mit.edu	37	3	186006620	186006620	+	Silent	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr3:186006620C>T	ENST00000265022.3	-	6	962	c.423G>A	c.(421-423)gcG>gcA	p.A141A	DGKG_ENST00000344484.4_Silent_p.A141A|DGKG_ENST00000544847.1_Silent_p.A141A|DGKG_ENST00000382164.4_Silent_p.A141A	NM_001080744.1|NM_001080745.1|NM_001346.2	NP_001074213.1|NP_001074214.1|NP_001337.2	P49619	DGKG_HUMAN	diacylglycerol kinase, gamma 90kDa	141					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	42	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	CCAGGGGGGTCGCAGCCACTT	0.512000													47	180					0	0	1	0	0
RFX5	5993	broad.mit.edu	37	1	151315450	151315450	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:151315450G>T	ENST00000290524.4	-	11	1241	c.1063C>A	c.(1063-1065)Ctt>Att	p.L355I	RFX5_ENST00000452513.2_Missense_Mutation_p.L315I|RFX5_ENST00000452671.2_Missense_Mutation_p.L355I|RFX5_ENST00000368870.2_Missense_Mutation_p.L355I	NM_000449.3|NM_001025603.1	NP_000440.1|NP_001020774.1	P48382	RFX5_HUMAN	regulatory factor X, 5 (influences HLA class II expression)	355						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	20	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CCTGAAGAAAGCCTGGGGGCC	0.587000													13	60					3.03607e-14	3.38639e-14	1	1	0
RLTPR	146206	broad.mit.edu	37	16	67679643	67679643	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr16:67679643G>C	ENST00000334583.6	+	3	477	c.149G>C	c.(148-150)aGa>aCa	p.R50T	RLTPR_ENST00000545661.1_Missense_Mutation_p.R50T	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	50								p.R50K(1)|p.R90K(1)		breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		CTACGATGGAGAGCCTACCTG	0.667000													10	77					0	0	1	0	0
ASB4	51666	broad.mit.edu	37	7	95125268	95125268	+	Missense_Mutation	SNP	G	G	A	rs141186023		TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr7:95125268G>A	ENST00000325885.5	+	2	457	c.386G>A	c.(385-387)cGt>cAt	p.R129H	ASB4_ENST00000257621.4_3'UTR|ASB4_ENST00000428113.1_Missense_Mutation_p.R129H	NM_016116.2	NP_057200.1	Q9Y574	ASB4_HUMAN	ankyrin repeat and SOCS box containing 4	129					intracellular signal transduction					central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(8)|pancreas(1)|prostate(1)|skin(2)	20	all_cancers(62;2.27e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.218)|all_lung(186;0.246)		STAD - Stomach adenocarcinoma(171;0.0151)			CTCTGTGATCGTGGGGCAAAG	0.458000													14	64					0	0	1	0	0
GPR89A	653519	broad.mit.edu	37	1	145771648	145771648	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:145771648C>T	ENST00000313835.9	-	11	1135	c.992G>A	c.(991-993)gGa>gAa	p.G331E	GPR89A_ENST00000478703.1_5'UTR|GPR89A_ENST00000462900.2_Missense_Mutation_p.G306E|GPR89A_ENST00000534502.1_Missense_Mutation_p.G306E|GPR89A_ENST00000454423.3_Missense_Mutation_p.G211E			B7ZAQ6	GPHRA_HUMAN	G protein-coupled receptor 89A	331					intracellular pH reduction|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein transport	Golgi cisterna membrane|Golgi-associated vesicle membrane|integral to membrane	signal transducer activity|voltage-gated anion channel activity			breast(1)|large_intestine(3)|lung(1)|skin(1)	6	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			AAATTGGATTCCCAGATAATT	0.343000													9	105					0	0	1	0	0
DEPDC5	9681	broad.mit.edu	37	22	32242867	32242867	+	Silent	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr22:32242867G>A	ENST00000400246.1	+	31	3211	c.3069G>A	c.(3067-3069)acG>acA	p.T1023T	DEPDC5_ENST00000382105.2_Silent_p.T945T|DEPDC5_ENST00000266091.3_Silent_p.T1023T|DEPDC5_ENST00000400249.2_Silent_p.T1014T|DEPDC5_ENST00000382111.2_Silent_p.T1023T|DEPDC5_ENST00000382112.3_Silent_p.T1014T|DEPDC5_ENST00000400248.2_Silent_p.T1014T|DEPDC5_ENST00000535622.1_Silent_p.T945T			O75140	DEPD5_HUMAN	DEP domain containing 5	1014					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						CCATTTCCACGCATTCTCTGG	0.552000													16	53					0	0	1	0	0
RARB	5915	broad.mit.edu	37	3	25542729	25542729	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr3:25542729G>C	ENST00000330688.4	+	3	784	c.363G>C	c.(361-363)aaG>aaC	p.K121N	RARB_ENST00000462272.1_3'UTR|RARB_ENST00000437042.2_Missense_Mutation_p.K9N|RARB_ENST00000404969.1_Missense_Mutation_p.K128N|RARB_ENST00000458646.1_Missense_Mutation_p.K9N	NM_000965.3	NP_000956.2	P10826	RARB_HUMAN	retinoic acid receptor, beta	128					embryonic digestive tract development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	protein binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|kidney(1)|large_intestine(10)|lung(11)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	28					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tamibarotene(DB04942)|Tazarotene(DB00799)	ACCGAGATAAGAACTGTGTTA	0.393000													8	90					0	0	1	0	0
SLITRK6	84189	broad.mit.edu	37	13	86368575	86368575	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr13:86368575T>C	ENST00000400286.2	-	2	2667	c.2069A>G	c.(2068-2070)tAt>tGt	p.Y690C		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	690						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TGGACTTCTATAGACATGAAC	0.443000													50	255					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6078422	6078422	+	Nonsense_Mutation	SNP	G	G	A	rs61751300		TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr12:6078422G>A	ENST00000261405.5	-	45	7938	c.7684C>T	c.(7684-7686)Cag>Tag	p.Q2562*		NM_000552.3	NP_000543	P04275	VWF_HUMAN	von Willebrand factor	2562					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	CAGCTCAGCTGAAAGCCCGAG	0.592000													7	23					0	0	1	0	0
ARFGEF2	10564	broad.mit.edu	37	20	47639592	47639592	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr20:47639592G>T	ENST00000371917.4	+	35	4629	c.4629G>T	c.(4627-4629)caG>caT	p.Q1543H		NM_006420.2	NP_006411.2	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	1543					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(7)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	63			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			ACATAGATCAGAAACTGTTTG	0.403000													9	120					3.07112e-06	3.19985e-06	1	1	0
ADCY9	115	broad.mit.edu	37	16	4016470	4016470	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr16:4016470G>A	ENST00000294016.3	-	11	3906	c.3368C>T	c.(3367-3369)gCg>gTg	p.A1123V		NM_001116.3	NP_001107.2	O60503	ADCY9_HUMAN	adenylate cyclase 9	1123	Guanylate cyclase 2.				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						CTGGGCCTGCGCGGTGTTCAG	0.602000													8	81					0	0	1	0	0
THOC5	8563	broad.mit.edu	37	22	29917075	29917075	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr22:29917075G>C	ENST00000490103.1	-	13	1311	c.1189C>G	c.(1189-1191)Cct>Gct	p.P397A	THOC5_ENST00000397872.1_Missense_Mutation_p.P397A|THOC5_ENST00000397873.2_Missense_Mutation_p.P397A|CTA-256D12.11_ENST00000411969.1_RNA|THOC5_ENST00000397871.1_Missense_Mutation_p.P397A	NM_003678.4	NP_003669.4	Q13769	THOC5_HUMAN	THO complex 5	397					intronless viral mRNA export from host nucleus|monocyte differentiation|mRNA processing|primitive hemopoiesis|RNA splicing	cytoplasm|intermediate filament cytoskeleton|THO complex part of transcription export complex	protein binding|RNA binding			NS(1)|breast(4)|cervix(1)|endometrium(2)|large_intestine(4)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						ACTGAGTCAGGAGACAGCAAG	0.453000													23	114					0	0	1	0	0
CYP4Z1	199974	broad.mit.edu	37	1	47548040	47548040	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:47548040G>A	ENST00000334194.3	+	4	402	c.399G>A	c.(397-399)tgG>tgA	p.W133*		NM_178134.2	NP_835235.1	Q86W10	CP4Z1_HUMAN	cytochrome P450, family 4, subfamily Z, polypeptide 1	133						endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			cervix(1)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	11						GTTCTAAATGGAAAAAGCACC	0.458000													7	41					0	0	1	0	0
GBP1	2633	broad.mit.edu	37	1	89523877	89523877	+	Silent	SNP	G	G	C			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:89523877G>C	ENST00000370473.4	-	6	891	c.672C>G	c.(670-672)ctC>ctG	p.L224L		NM_002053.2	NP_002044.2	P32455	GBP1_HUMAN	guanylate binding protein 1, interferon-inducible	224					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			endometrium(7)|kidney(4)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	30		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		TCCGGATACAGAGTCTGGGCA	0.393000													22	395					0	0	1	0	0
MFRP	83552	broad.mit.edu	37	11	119216184	119216184	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr11:119216184G>T	ENST00000555262.1	-	5	746	c.587C>A	c.(586-588)tCt>tAt	p.S196Y	C1QTNF5_ENST00000445041.2_5'UTR|MFRP_ENST00000529147.1_5'UTR|MFRP_ENST00000449574.2_Missense_Mutation_p.S196Y|MFRP_ENST00000530681.1_Missense_Mutation_p.S196Y|MFRP_ENST00000360167.4_Missense_Mutation_p.S196Y	NM_001278431.1	NP_001265360.1			membrane frizzled-related protein											autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)|urinary_tract(1)	18		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		AAAAAGGCAAGAGGCCACACT	0.582000													4	45					3.59834e-05	3.7048e-05	1	1	0
XIRP2	129446	broad.mit.edu	37	2	168101824	168101824	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:168101824G>A	ENST00000409195.1	+	9	4011	c.3922G>A	c.(3922-3924)Gat>Aat	p.D1308N	XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.D1308N|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.D1086N	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1133					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AATACAGGGTGATGTAAAAAG	0.368000													14	73					0	0	1	0	0
MAP4	4134	broad.mit.edu	37	3	47908773	47908773	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr3:47908773G>A	ENST00000426837.2	-	17	6551	c.6464C>T	c.(6463-6465)tCc>tTc	p.S2155F	MAP4_ENST00000264724.11_Missense_Mutation_p.S745F|MAP4_ENST00000420772.2_Missense_Mutation_p.S703F|MAP4_ENST00000395734.3_Missense_Mutation_p.S1010F|MAP4_ENST00000441748.2_Missense_Mutation_p.S124F|MAP4_ENST00000383737.4_Intron|MAP4_ENST00000360240.6_Missense_Mutation_p.S1010F			P27816	MAP4_HUMAN	microtubule-associated protein 4	1010					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(2)	32				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		ATTGTCCTTGGAACCACACTT	0.438000													13	92					0	0	1	0	0
SNAPC4	6621	broad.mit.edu	37	9	139273423	139273423	+	Silent	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr9:139273423G>A	ENST00000298532.2	-	21	3224	c.2856C>T	c.(2854-2856)ctC>ctT	p.L952L		NM_003086.2	NP_003077.2	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex, polypeptide 4, 190kDa	952	Pro-rich.				snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	33		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		CAGGCCCAGAGAGCGGTACAT	0.657000													5	6					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29821479	29821479	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr10:29821479T>A	ENST00000375398.2	-	10	2266	c.1817A>T	c.(1816-1818)aAc>aTc	p.N606I	SVIL_ENST00000375400.3_Intron|SVIL_ENST00000355867.4_Missense_Mutation_p.N606I			O95425	SVIL_HUMAN	supervillin	606					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				CCTGCAGGCGTTGGCAGATGC	0.577000													8	27					0	0	1	0	0
RP11-50E11.3	0	broad.mit.edu	37	10	52389979	52389979	+	RNA	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr10:52389979C>T	ENST00000443374.2	+	0	1168																											ATAGTCTCCCCGTAGGCCTTC	0.393000													7	21					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44086513	44086513	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:44086513G>A	ENST00000359947.4	+	32	5709	c.5369G>A	c.(5368-5370)gGg>gAg	p.G1790E	PTPRF_ENST00000438120.1_Missense_Mutation_p.G1781E|PTPRF_ENST00000422171.2_Missense_Mutation_p.G1149E|PTPRF_ENST00000372413.3_Missense_Mutation_p.G1781E|PTPRF_ENST00000496447.1_3'UTR|PTPRF_ENST00000372414.3_Missense_Mutation_p.G1790E	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1790	Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TCCCAGGATGGGCAGTCAAGG	0.557000													12	36					0	0	1	0	0
AXL	558	broad.mit.edu	37	19	41745178	41745178	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr19:41745178G>C	ENST00000301178.4	+	9	1434	c.1244G>C	c.(1243-1245)gGa>gCa	p.G415A	AXL_ENST00000359092.3_Missense_Mutation_p.G415A|AXL_ENST00000593513.1_Missense_Mutation_p.G147A	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	415	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						GCTGGGGATGGACCCTGGAGC	0.617000													19	55					0	0	1	0	0
NCOR1	9611	broad.mit.edu	37	17	16089958	16089958	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr17:16089958C>T	ENST00000268712.3	-	3	409	c.152G>A	c.(151-153)aGt>aAt	p.S51N	NCOR1_ENST00000395848.1_Intron|NCOR1_ENST00000395851.1_Missense_Mutation_p.S51N	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	51	Interaction with ZBTB33 and HEXIM1.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		TGATGCCTGACTCACTTCAAG	0.413000													9	61					0	0	1	0	0
USHBP1	83878	broad.mit.edu	37	19	17367354	17367354	+	Silent	SNP	G	G	A	rs141680124	byFrequency	TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr19:17367354G>A	ENST00000252597.3	-	9	1569	c.1396C>T	c.(1396-1398)Ctg>Ttg	p.L466L	USHBP1_ENST00000431146.2_Silent_p.L402L	NM_031941.3	NP_114147.2	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	466							PDZ domain binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(10)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44						TGGGTCCCCAGAATGGCCTGC	0.612000													21	85					0	0	1	0	0
SLC27A6	28965	broad.mit.edu	37	5	128368806	128368806	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr5:128368806T>A	ENST00000262462.4	+	10	2701	c.1691T>A	c.(1690-1692)aTg>aAg	p.M564K	SLC27A6_ENST00000506176.1_Missense_Mutation_p.M564K|SLC27A6_ENST00000395266.1_Missense_Mutation_p.M564K			Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid transporter), member 6	564					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding			NS(2)|endometrium(1)|kidney(3)|large_intestine(11)|liver(1)|lung(20)|prostate(1)|skin(4)|stomach(1)	44		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		CAGGAAAAAATGGAAGCAACA	0.289000													6	22					0	0	1	0	0
KDM6B	23135	broad.mit.edu	37	17	7751845	7751845	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr17:7751845C>G	ENST00000254846.5	+	11	2628	c.2239C>G	c.(2239-2241)Cct>Gct	p.P747A	KDM6B_ENST00000448097.2_Missense_Mutation_p.P747A	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	747	Pro-rich.|Thr-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						CACTACTGCTCCTGCTGTCGC	0.652000													6	48					0	0	1	0	0
DIAPH2	1730	broad.mit.edu	37	X	96213049	96213049	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chrX:96213049C>T	ENST00000324765.8	+	16	2184	c.1837C>T	c.(1837-1839)Cct>Tct	p.P613S	DIAPH2_ENST00000355827.4_Missense_Mutation_p.P613S|DIAPH2_ENST00000373049.4_Missense_Mutation_p.P613S|DIAPH2_ENST00000373061.3_Missense_Mutation_p.P613S|DIAPH2_ENST00000373054.4_Missense_Mutation_p.P609S			O60879	DIAP2_HUMAN	diaphanous-related formin 2	613	FH1.|Poly-Pro.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51						TGGAGGAGTTCCTCCTCCCCC	0.478000													16	25					0	0	1	0	0
MRPS26	64949	broad.mit.edu	37	20	3028475	3028475	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr20:3028475G>C	ENST00000380325.3	+	4	702	c.578G>C	c.(577-579)aGa>aCa	p.R193T		NM_030811.3	NP_110438.1	Q9BYN8	RT26_HUMAN	mitochondrial ribosomal protein S26	193					DNA damage response, detection of DNA damage	mitochondrial small ribosomal subunit				kidney(1)|lung(1)	2						GCCATCACCAGAGAGGGGCTG	0.582000													4	49					0	0	1	0	0
KDM5C	8242	broad.mit.edu	37	X	53228048	53228048	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chrX:53228048G>T	ENST00000452825.3	-	14	2597	c.2065C>A	c.(2065-2067)Ctt>Att	p.L689I	KDM5C_ENST00000375401.3_Missense_Mutation_p.L756I|KDM5C_ENST00000404049.3_Missense_Mutation_p.L755I|KDM5C_ENST00000375379.3_Missense_Mutation_p.L756I|KDM5C_ENST00000375383.3_Missense_Mutation_p.L715I	NM_001146702.1	NP_001140174.1	P41229	KDM5C_HUMAN	lysine (K)-specific demethylase 5C	756					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding	p.L756I(3)|p.L689I(2)		autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(30)|large_intestine(9)|lung(17)|oesophagus(1)|ovary(6)|prostate(1)|salivary_gland(1)|skin(1)|upper_aerodigestive_tract(2)	82						ATGGCAGGAAGCTCATCCAAG	0.587000			"""N, F, S"""		clear cell renal carcinoma								7	48					0.0293803	0.0293803	1	1	0
C12orf74	338809	broad.mit.edu	37	12	93100779	93100779	+	Silent	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr12:93100779C>T	ENST00000544406.2	+	2	638	c.372C>T	c.(370-372)ccC>ccT	p.P124P	C12orf74_ENST00000397833.3_Silent_p.P124P			Q32Q52	CL074_HUMAN	chromosome 12 open reading frame 74	124										kidney(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(2)	10						CACTGGAGCCCCAAACCCGGC	0.557000													6	79					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117303215	117303215	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr11:117303215C>T	ENST00000321322.6	-	30	5213	c.5212G>A	c.(5212-5214)Gac>Aac	p.D1738N	DSCAML1_ENST00000527706.1_Missense_Mutation_p.D1468N	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1678					axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		GTGGCCTTGTCATCTCCTGGG	0.463000													7	72					0	0	1	0	0
FRMPD3	84443	broad.mit.edu	37	X	106846360	106846360	+	Silent	SNP	G	G	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chrX:106846360G>T	ENST00000276185.4	+	16	5190	c.5190G>T	c.(5188-5190)gtG>gtT	p.V1730V				Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	1730						cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						AAGAGGTGGTGAGGAACTACA	0.582000													7	10					0.0293803	0.0293803	1	1	0
DHDH	27294	broad.mit.edu	37	19	49442919	49442919	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr19:49442919C>G	ENST00000221403.2	+	4	620	c.580C>G	c.(580-582)Cca>Gca	p.P194A	DHDH_ENST00000523250.1_Intron|DHDH_ENST00000522614.1_Missense_Mutation_p.P194A	NM_014475.3	NP_055290.1	Q9UQ10	DHDH_HUMAN	dihydrodiol dehydrogenase (dimeric)	194					carbohydrate metabolic process		binding|D-xylose 1-dehydrogenase (NADP+) activity|electron carrier activity|NAD(P)+ transhydrogenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity			central_nervous_system(1)|large_intestine(3)|lung(3)|ovary(1)|soft_tissue(1)	9		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000158)|all cancers(93;0.000258)|Epithelial(262;0.0173)|GBM - Glioblastoma multiforme(486;0.0179)		AGGGCAGAAGCCAGAGAAGAT	0.562000													7	102					0	0	1	0	0
PRICKLE1	144165	broad.mit.edu	37	12	42853914	42853914	+	Nonsense_Mutation	SNP	G	G	T	rs137985321	byFrequency	TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr12:42853914G>T	ENST00000455697.1	-	8	2478	c.2193C>A	c.(2191-2193)taC>taA	p.Y731*	PRICKLE1_ENST00000445766.2_Nonsense_Mutation_p.Y731*|PRICKLE1_ENST00000552240.1_Nonsense_Mutation_p.Y731*|RP11-328C8.4_ENST00000547824.1_RNA|PRICKLE1_ENST00000345127.3_Nonsense_Mutation_p.Y731*|PRICKLE1_ENST00000548696.1_Nonsense_Mutation_p.Y731*	NM_001144882.1|NM_001144883.1	NP_001138354.1|NP_001138355.1	Q96MT3	PRIC1_HUMAN	prickle homolog 1 (Drosophila)	731					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(13)|ovary(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	47	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		CGTACTGTCCGTAGAGATCAG	0.493000													17	83					1.5739e-10	1.71161e-10	1	1	0
SEZ6	124925	broad.mit.edu	37	17	27308687	27308687	+	Silent	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr17:27308687C>T	ENST00000317338.12	-	2	854	c.426G>A	c.(424-426)ccG>ccA	p.P142P	PIPOX_ENST00000583215.1_Intron|SEZ6_ENST00000360295.9_Silent_p.P142P|SEZ6_ENST00000442608.3_Silent_p.P142P|SEZ6_ENST00000335960.6_Silent_p.P142P			Q53EL9	SEZ6_HUMAN	seizure related 6 homolog (mouse)	142	Pro-rich.					integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(4)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	29	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			ACTCTGACTCCGGACTCCAGG	0.647000													5	36					0	0	1	0	0
OXSM	54995	broad.mit.edu	37	3	25835785	25835785	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr3:25835785G>A	ENST00000280701.3	+	3	1279	c.1180G>A	c.(1180-1182)Gag>Aag	p.E394K	OXSM_ENST00000420173.2_Missense_Mutation_p.E311K	NM_017897.2	NP_060367.1	Q9NWU1	OXSM_HUMAN	3-oxoacyl-ACP synthase, mitochondrial	394					acyl-CoA metabolic process|medium-chain fatty acid biosynthetic process|short-chain fatty acid biosynthetic process	mitochondrion	3-oxoacyl-[acyl-carrier-protein] synthase activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	25						AGGGGCAGTCGAGGCAGCTTT	0.438000													16	88					0	0	1	0	0
EEA1	8411	broad.mit.edu	37	12	93244925	93244925	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr12:93244925C>T	ENST00000322349.8	-	9	1024	c.760G>A	c.(760-762)Gaa>Aaa	p.E254K		NM_003566.3	NP_003557	Q15075	EEA1_HUMAN	early endosome antigen 1	254					early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(11)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	36						TTTTTGCATTCATCTTTGAGT	0.363000													8	48					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	79082591	79082591	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr7:79082591G>A	ENST00000354212.4	-	1	299	c.46C>T	c.(46-48)Cat>Tat	p.H16Y	MAGI2-AS3_ENST00000446159.1_RNA|MAGI2-AS3_ENST00000429408.1_RNA|MAGI2_ENST00000419488.1_Missense_Mutation_p.H16Y|MAGI2-AS3_ENST00000426835.1_RNA|MAGI2_ENST00000522391.1_Missense_Mutation_p.H16Y	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	16						cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				ACACTCTCATGGACTTTGCTA	0.592000													24	124					0	0	1	0	0
STRN4	29888	broad.mit.edu	37	19	47236403	47236403	+	Silent	SNP	G	G	A	rs146403716		TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr19:47236403G>A	ENST00000391910.3	-	5	1080	c.630C>T	c.(628-630)aaC>aaT	p.N210N	STRN4_ENST00000539396.1_Silent_p.N91N|STRN4_ENST00000263280.6_Silent_p.N210N			Q9NRL3	STRN4_HUMAN	striatin, calmodulin binding protein 4	210						cytoplasm|membrane	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000563)|all cancers(93;0.00138)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.035)		CCACTGCCCCGTTGAGCTCCA	0.662000													7	34					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129475825	129475825	+	Silent	SNP	A	A	G			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr6:129475825A>G	ENST00000421865.2	+	8	1252	c.1203A>G	c.(1201-1203)aaA>aaG	p.K401K		NM_000426.3|NM_001079823.1	NP_000417|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	401	Laminin EGF-like 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TCAGACCCAAAGGGGTAAAGT	0.333000													5	50					0	0	1	0	0
OR2L3	391192	broad.mit.edu	37	1	248224518	248224518	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:248224518G>A	ENST00000359959.3	+	1	535	c.535G>A	c.(535-537)Gat>Aat	p.D179N	OR2L13_ENST00000366478.2_Intron	NM_001004687.1	NP_001004687.1	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L, member 3	179					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(28)|prostate(1)|skin(1)|urinary_tract(1)	41	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TTTCTTCTGTGATGTCCCAGC	0.478000													30	135					0	0	1	0	0
SMYD5	10322	broad.mit.edu	37	2	73446021	73446021	+	Silent	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:73446021G>A	ENST00000389501.4	+	2	174	c.129G>A	c.(127-129)cgG>cgA	p.R43R	SMYD5_ENST00000474652.1_3'UTR	NM_006062.2	NP_006053.2	Q6GMV2	SMYD5_HUMAN	SMYD family member 5	43							metal ion binding			NS(1)|breast(1)|endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)	13						AGCTCATCCGGAAGGGGGAGA	0.542000													10	42					0	0	1	0	0
OR10R2	343406	broad.mit.edu	37	1	158449927	158449927	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:158449927C>G	ENST00000368152.1	+	1	260	c.260C>G	c.(259-261)tCa>tGa	p.S87*	RP11-144L1.4_ENST00000426251.1_RNA|RP11-144L1.4_ENST00000419738.1_RNA	NM_001004472.1	NP_001004472.1	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R, member 2	87					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S87L(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(26)|pancreas(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	41	all_hematologic(112;0.0378)					GGCATTCTCTCAACATCTGAG	0.433000													27	172					0	0	1	0	0
PAN3	255967	broad.mit.edu	37	13	28794473	28794473	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr13:28794473C>T	ENST00000399613.1	+	5	421	c.358C>T	c.(358-360)Cac>Tac	p.H120Y	PAN3_ENST00000380958.3_Missense_Mutation_p.H320Y			Q58A45	PAN3_HUMAN	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	320	Interaction with polyadenylate-binding protein.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			endometrium(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)		AGTTTTCTCTCACCCATCCAT	0.458000													33	147					0	0	1	0	0
NOX4	50507	broad.mit.edu	37	11	89133385	89133385	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr11:89133385G>A	ENST00000535633.1	-	10	1247	c.937C>T	c.(937-939)Cag>Tag	p.Q313*	NOX4_ENST00000424319.1_Nonsense_Mutation_p.Q313*|NOX4_ENST00000532825.1_Nonsense_Mutation_p.Q313*|NOX4_ENST00000542487.1_Nonsense_Mutation_p.Q313*|NOX4_ENST00000528341.1_Nonsense_Mutation_p.Q312*|NOX4_ENST00000343727.5_Nonsense_Mutation_p.Q313*|NOX4_ENST00000375979.3_Intron|NOX4_ENST00000534731.1_Nonsense_Mutation_p.Q337*|NOX4_ENST00000531342.1_Intron|NOX4_ENST00000527956.1_Nonsense_Mutation_p.Q313*|NOX4_ENST00000525196.1_Intron|NOX4_ENST00000263317.4_Nonsense_Mutation_p.Q337*|NOX4_ENST00000413594.2_Nonsense_Mutation_p.Q358*|NOX4_ENST00000527626.1_Nonsense_Mutation_p.Q171*	NM_001143836.1|NM_016931.3	NP_001137308.1|NP_058627.1	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4	337	FAD-binding FR-type.|Mediates interaction with TLR4.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(20)|ovary(2)|prostate(3)|skin(2)	44		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				TGACTCACCTGACCAGGTCTT	0.373000													9	98					0	0	1	0	0
MAMDC4	158056	broad.mit.edu	37	9	139754441	139754441	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr9:139754441G>C	ENST00000445819.1	+	28	3584	c.3534G>C	c.(3532-3534)caG>caC	p.Q1178H	MAMDC4_ENST00000485732.1_3'UTR|MAMDC4_ENST00000317446.2_Missense_Mutation_p.Q1099H			Q6UXC1	AEGP_HUMAN	MAM domain containing 4	1178					protein transport	integral to membrane				breast(4)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	19	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		GCTGGCTGCAGAAGAAGGGGA	0.632000													5	14					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49445170	49445170	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr12:49445170C>T	ENST00000301067.7	-	10	2295	c.2296G>A	c.(2296-2298)Gag>Aag	p.E766K		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		TGTGGCTCCTCAGCCTGCGGA	0.697000													5	39					0	0	1	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107446656	107446656	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:107446656A>C	ENST00000409382.3	-	5	1794	c.1184T>G	c.(1183-1185)aTt>aGt	p.I395S	ST6GAL2_ENST00000361686.4_Missense_Mutation_p.I395S|ST6GAL2_ENST00000409087.3_Missense_Mutation_p.I395S	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	395					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						ACGATGCTGAATATATGGAGT	0.368000													20	86					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	73046848	73046848	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr12:73046848G>A	ENST00000261180.4	+	17	2857	c.2761G>A	c.(2761-2763)Gat>Aat	p.D921N		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	921					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						AGATGCAATTGATGTCATAAT	0.353000													6	59					0	0	1	0	0
CASP9	842	broad.mit.edu	37	1	15831211	15831211	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:15831211C>T	ENST00000546424.1	-	6	1007	c.763G>A	c.(763-765)Gga>Aga	p.G255R	CASP9_ENST00000348549.5_Intron|CASP9_ENST00000333868.5_Missense_Mutation_p.G255R|CASP9_ENST00000375890.4_Missense_Mutation_p.G172R			P55211	CASP9_HUMAN	caspase 9, apoptosis-related cysteine peptidase	255					activation of caspase activity by cytochrome c|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol	cysteine-type endopeptidase activity|enzyme activator activity|protein binding			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|stomach(1)	18		Breast(348;0.000207)|all_lung(284;0.000211)|Colorectal(325;0.000259)|Lung NSC(340;0.000269)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;8.49e-07)|COAD - Colon adenocarcinoma(227;4.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00013)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00763)|READ - Rectum adenocarcinoma(331;0.0655)		ACAGGGCATCCATCTGTGCCG	0.552000													15	63					0	0	1	0	0
ASXL1	171023	broad.mit.edu	37	20	31021672	31021672	+	Silent	SNP	C	C	G			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr20:31021672C>G	ENST00000375687.4	+	12	2095	c.1671C>G	c.(1669-1671)acC>acG	p.T557T	ASXL1_ENST00000306058.5_Silent_p.T552T	NM_015338.5	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 (Drosophila)	557					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(655)|kidney(5)|large_intestine(18)|liver(1)|lung(27)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	722						GTGTTCACACCGAAAAGCCAC	0.537000			"""F, N, Mis"""		"""MDS, CMML"""								24	128					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6078430	6078430	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr12:6078430G>A	ENST00000261405.5	-	45	7930	c.7676C>T	c.(7675-7677)tCg>tTg	p.S2559L		NM_000552.3	NP_000543	P04275	VWF_HUMAN	von Willebrand factor	2559					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding	p.S2559L(1)		NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	CTGAAAGCCCGAGGGGCAGAC	0.592000													9	25					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51174110	51174110	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr16:51174110G>C	ENST00000440970.1	-	2	2163	c.1732C>G	c.(1732-1734)Cct>Gct	p.P578A	SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.P675A	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	675					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.P675S(1)		NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CCCCCAAAAGGAAACTTGGCC	0.582000													11	80					0	0	1	0	0
GPX1	2876	broad.mit.edu	37	3	49394857	49394857	+	Silent	SNP	G	G	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr3:49394857G>T	ENST00000419783.1	-	2	897	c.576C>A	c.(574-576)atC>atA	p.I192I	GPX1_ENST00000419349.1_3'UTR	NM_000581.2	NP_000572.2	P07203	GPX1_HUMAN	glutathione peroxidase 1	192					anti-apoptosis|cell redox homeostasis|glutathione metabolic process|heart contraction|hydrogen peroxide catabolic process|negative regulation of caspase activity|purine base metabolic process|purine nucleotide catabolic process|regulation of gene expression, epigenetic|regulation of mammary gland epithelial cell proliferation|regulation of proteasomal protein catabolic process|release of cytochrome c from mitochondria|response to selenium ion|UV protection	cytosol|mitochondrion	endopeptidase inhibitor activity|glutathione peroxidase activity|SH3 domain binding			breast(1)|large_intestine(2)|lung(1)	4				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Glutathione(DB00143)	GCAGGGCTTCGATGTCAGGCT	0.617000													7	45					2.7689e-08	2.974e-08	1	1	0
AKAP9	10142	broad.mit.edu	37	7	91625086	91625086	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr7:91625086T>C	ENST00000359028.2	+	8	1163	c.938T>C	c.(937-939)tTg>tCg	p.L313S	AKAP9_ENST00000394564.1_Missense_Mutation_p.L301S|AKAP9_ENST00000358100.2_Missense_Mutation_p.L313S|AKAP9_ENST00000356239.3_Missense_Mutation_p.L301S			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	313					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			ATTAGTTTCTTGCAAGAGAAA	0.318000			T	BRAF	papillary thyroid								8	27					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38213252	38213252	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr13:38213252G>T	ENST00000379705.3	-	10	2993	c.2136C>A	c.(2134-2136)aaC>aaA	p.N712K	TRPC4_ENST00000355779.2_Missense_Mutation_p.N712K|TRPC4_ENST00000379679.1_Missense_Mutation_p.N539K|TRPC4_ENST00000379673.2_Missense_Mutation_p.N647K|TRPC4_ENST00000358477.2_Missense_Mutation_p.N712K|TRPC4_ENST00000426868.2_3'UTR|TRPC4_ENST00000447043.1_Missense_Mutation_p.N712K|TRPC4_ENST00000338947.5_Missense_Mutation_p.N539K|TRPC4_ENST00000379681.3_Missense_Mutation_p.N717K			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	712	Binds to ITPR1, ITPR2 and ITPR3.				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		GCTTCACCAGGTTCCTCATAA	0.398000													18	174					2.94398e-08	3.14266e-08	1	1	0
CX3CL1	6376	broad.mit.edu	37	16	57416922	57416922	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr16:57416922C>T	ENST00000565912.1	+	2	3764	c.1058C>T	c.(1057-1059)tCa>tTa	p.S353L	CX3CL1_ENST00000006053.6_Missense_Mutation_p.S391L|CX3CL1_ENST00000563383.1_Missense_Mutation_p.S397L			P78423	X3CL1_HUMAN	chemokine (C-X3-C motif) ligand 1	391					cell adhesion|cytokine-mediated signaling pathway|defense response|immune response|leukocyte adhesive activation|positive regulation of calcium-independent cell-cell adhesion|positive regulation of inflammatory response	cell surface|extracellular space|integral to membrane|plasma membrane	chemokine activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)	5						GGTAGTAATTCATATGTCCTG	0.577000													11	84					0	0	1	0	0
LARP6	55323	broad.mit.edu	37	15	71125360	71125360	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr15:71125360C>G	ENST00000299213.8	-	3	577	c.507G>C	c.(505-507)agG>agC	p.R169S		NM_018357.2	NP_060827.2	Q9BRS8	LARP6_HUMAN	La ribonucleoprotein domain family, member 6	169	HTH La-type RNA-binding.				RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	19						CGGGGGTGGTCCTCCTCACCT	0.547000													6	42					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179542881	179542881	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:179542881G>A	ENST00000589042.1	-	145	34189	c.33965C>T	c.(33964-33966)cCg>cTg	p.P11322L	TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.P11005L|TTN_ENST00000342992.6_Missense_Mutation_p.P10078L|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11005	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.P10078L(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACTTTTTTCGGAACAGGTGT	0.358000													7	79					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128302401	128302401	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr6:128302401C>T	ENST00000368227.3	-	26	3988	c.3622G>A	c.(3622-3624)Gaa>Aaa	p.E1208K	PTPRK_ENST00000368226.4_Missense_Mutation_p.E1191K|PTPRK_ENST00000368215.3_Missense_Mutation_p.E1190K|PTPRK_ENST00000368210.3_Missense_Mutation_p.E1209K|PTPRK_ENST00000368213.5_Missense_Mutation_p.E1197K|PTPRK_ENST00000368207.3_Missense_Mutation_p.E1223K|PTPRK_ENST00000532331.1_Missense_Mutation_p.E1213K			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1190	Tyrosine-protein phosphatase 2.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		CTGCAGTCTTCAGCTTGTAGT	0.428000													5	25					0	0	1	0	0
PSG9	5678	broad.mit.edu	37	19	43763021	43763021	+	Silent	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr19:43763021G>A	ENST00000418820.2	-	3	795	c.697C>T	c.(697-699)Cta>Tta	p.L233L	PSG9_ENST00000593948.1_Intron|PSG9_ENST00000596730.1_Intron|PSG9_ENST00000291752.5_Intron|PSG9_ENST00000443718.3_Silent_p.L233L|PSG9_ENST00000270077.3_Silent_p.L326L|PSG9_ENST00000244293.7_Intron			Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	233	Ig-like C2-type 1.				female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Prostate(69;0.00682)				AGGACATTTAGGATGACTGGG	0.507000													11	140					0	0	1	0	0
ADARB2	105	broad.mit.edu	37	10	1405298	1405298	+	Silent	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr10:1405298G>A	ENST00000381312.1	-	3	1327	c.1002C>T	c.(1000-1002)gcC>gcT	p.A334A		NM_018702.3	NP_061172.1	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2 (non-functional)	334	DRBM 2.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	41		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		CCTGCAGTGCGGCCTGCGCGG	0.746000													3	9					0	0	1	0	0
NYAP2	57624	broad.mit.edu	37	2	226447640	226447640	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:226447640C>T	ENST00000272907.6	+	4	1920	c.1507C>T	c.(1507-1509)Cgg>Tgg	p.R503W	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	503																	GGGTGGCTCCCGGTCCCGGAC	0.687000													6	24					0	0	1	0	0
LIG4	3981	broad.mit.edu	37	13	108860901	108860901	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr13:108860901C>T	ENST00000356922.4	-	2	2988	c.2716G>A	c.(2716-2718)Gaa>Aaa	p.E906K	LIG4_ENST00000405925.1_Missense_Mutation_p.E906K|LIG4_ENST00000442234.1_Missense_Mutation_p.E906K	NM_002312.3|NM_206937.1	NP_002303.2|NP_996820.1	P49917	DNLI4_HUMAN	ligase IV, DNA, ATP-dependent	906	BRCT 2.				cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					TACTGGTTTTCTTCTTGTAAT	0.333000								Non-homologous end-joining					11	25					0	0	1	0	0
NDUFS4	4724	broad.mit.edu	37	5	52856471	52856471	+	Translation_Start_Site	SNP	C	C	A	rs144843461	by1000genomes	TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr5:52856471C>A	ENST00000296684.5	+	0	7					NM_002495.2	NP_002486.1	O43181	NDUS4_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)						brain development|cAMP-mediated signaling|mitochondrial electron transport, NADH to ubiquinone|mitochondrial respiratory chain complex I assembly|positive regulation of fibroblast proliferation|reactive oxygen species metabolic process|regulation of protein phosphorylation|response to cAMP|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(3)	10		Lung NSC(810;8.27e-05)|Breast(144;0.0848)			NADH(DB00157)	GTCCTTTCATCCTGGCGTTTG	0.507000													22	56					4.35082e-09	4.70212e-09	1	1	0
KMT2D	8085	broad.mit.edu	37	12	49444391	49444391	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr12:49444391C>A	ENST00000301067.7	-	11	2979	c.2980G>T	c.(2980-2982)Gag>Tag	p.E994*		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GGGACAGGCTCAGGGTCAGTG	0.622000													6	35					5.9392e-07	6.22543e-07	1	1	0
PPP6R1	22870	broad.mit.edu	37	19	55758399	55758399	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr19:55758399G>A	ENST00000412770.2	-	2	639	c.73C>T	c.(73-75)Ccc>Tcc	p.P25S	PPP6R1_ENST00000587283.1_Missense_Mutation_p.P25S	NM_014931.3	NP_055746.3	Q9UPN7	PP6R1_HUMAN	protein phosphatase 6, regulatory subunit 1	25	Interaction with PPP6C.				regulation of phosphoprotein phosphatase activity	cytoplasm	protein phosphatase binding			breast(1)	1						AGCAGCTCGGGCAGGCTCAGG	0.612000													7	101					0	0	1	0	0
PDE5A	8654	broad.mit.edu	37	4	120549736	120549736	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr4:120549736C>T	ENST00000354960.3	-	1	410	c.91G>A	c.(91-93)Gaa>Aaa	p.E31K		NM_001083.3	NP_001074.2	O76074	PDE5A_HUMAN	phosphodiesterase 5A, cGMP-specific	31					platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding			breast(4)|endometrium(2)|kidney(3)|large_intestine(8)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	27					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	AGCCATGCTTCGACCGAGTCC	0.597000											OREG0016307	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	77					0	0	1	0	0
KRT14	3861	broad.mit.edu	37	17	39740032	39740032	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr17:39740032C>T	ENST00000167586.6	-	4	993	c.907G>A	c.(907-909)Gag>Aag	p.E303K		NM_000526.4	NP_000517	P02533	K1C14_HUMAN	keratin 14	303	Coil 2.|Rod.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(3)|lung(7)|ovary(1)|prostate(5)|skin(1)|stomach(1)	25		Breast(137;0.000307)				AACCATTCCTCGGCATCCTTG	0.542000													28	249					0	0	1	0	0
RPS6	6194	broad.mit.edu	37	9	19376294	19376294	+	Silent	SNP	T	T	C			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr9:19376294T>C	ENST00000380394.4	-	6	805	c.747A>G	c.(745-747)aaA>aaG	p.K249K	RPS6_ENST00000498815.1_5'UTR|RPS6_ENST00000315377.4_Silent_p.K218K|RPS6_ENST00000380384.1_Silent_p.K218K	NM_001010.2	NP_001001.2	P62753	RS6_HUMAN	ribosomal protein S6	249					endocrine pancreas development|glucose homeostasis|insulin receptor signaling pathway|positive regulation of apoptosis|rRNA processing|TOR signaling cascade|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	protein binding			endometrium(3)|lung(2)|ovary(1)|urinary_tract(1)	7		Colorectal(97;3.46e-05)|Myeloproliferative disorder(762;0.0255)		Lung(42;0.161)|LUSC - Lung squamous cell carcinoma(42;0.234)		AAAAATCTTATTTCTGACTGG	0.383000													8	76					0	0	1	0	0
ZNF311	282890	broad.mit.edu	37	6	28967310	28967310	+	Silent	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr6:28967310G>A	ENST00000377179.3	-	5	776	c.264C>T	c.(262-264)ctC>ctT	p.L88L	ZNF311_ENST00000483450.1_5'UTR	NM_001010877.2	NP_001010877.2	Q5JNZ3	ZN311_HUMAN	zinc finger protein 311	88					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|skin(3)|upper_aerodigestive_tract(2)	28						CATCCTTATAGAGATGCCTTT	0.398000													7	88					0	0	1	0	0
RNF182	221687	broad.mit.edu	37	6	13977507	13977507	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr6:13977507G>C	ENST00000488300.1	+	3	680	c.157G>C	c.(157-159)Gac>Cac	p.D53H	RNF182_ENST00000537388.1_Missense_Mutation_p.D53H|RNF182_ENST00000537663.1_Missense_Mutation_p.D53H|RNF182_ENST00000544682.1_Missense_Mutation_p.D53H	NM_152737.3	NP_689950.1	Q8N6D2	RN182_HUMAN	ring finger protein 182	53						cytoplasm|integral to membrane|intracellular membrane-bounded organelle	protein binding|ubiquitin-protein ligase activity|zinc ion binding	p.D53Y(1)		cervix(1)|large_intestine(7)|liver(2)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15	Breast(50;0.00405)|Ovarian(93;0.0964)	all_hematologic(90;0.135)	Epithelial(50;0.195)			CAAGATCATAGACTTTGGGGA	0.463000													11	164					0	0	1	0	0
RCOR3	55758	broad.mit.edu	37	1	211433478	211433478	+	Nonsense_Mutation	SNP	C	C	A	rs145681038	byFrequency	TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:211433478C>A	ENST00000367005.4	+	1	162	c.21C>A	c.(19-21)taC>taA	p.Y7*	RCOR3_ENST00000452621.2_Nonsense_Mutation_p.Y65*|RCOR3_ENST00000419091.2_Nonsense_Mutation_p.Y65*|RCOR3_ENST00000367006.4_Nonsense_Mutation_p.Y65*	NM_018254.3	NP_060724.1	Q9P2K3	RCOR3_HUMAN	REST corepressor 3	7	ELM2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(81;0.00961)|all cancers(67;0.0999)|Epithelial(68;0.171)		GAGCCGAATACCAAGCTCGGA	0.403000													25	27					9.39395e-14	1.04111e-13	1	1	0
DAB2	1601	broad.mit.edu	37	5	39377092	39377092	+	Silent	SNP	A	A	G			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr5:39377092A>G	ENST00000320816.6	-	12	2264	c.1797T>C	c.(1795-1797)ttT>ttC	p.F599F	DAB2_ENST00000339788.6_Silent_p.F381F|DAB2_ENST00000509337.1_Silent_p.F578F|DAB2_ENST00000545653.1_Silent_p.F578F	NM_001343.3	NP_001334.2	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	599					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			CAGGAGCTGGAAAAATATTGC	0.572000											OREG0016586	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	151					0	0	1	0	0
CNTROB	116840	broad.mit.edu	37	17	7836462	7836462	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr17:7836462C>T	ENST00000380262.3	+	1	990	c.65C>T	c.(64-66)tCa>tTa	p.S22L	CNTROB_ENST00000565740.1_Missense_Mutation_p.S22L|CNTROB_ENST00000563694.1_Missense_Mutation_p.S22L|CNTROB_ENST00000380255.3_Missense_Mutation_p.S22L	NM_001037144.5	NP_001032221.1	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	22					centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)	25		Prostate(122;0.173)				AGTGATTCATCAGAACCCCCT	0.602000													14	145					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176665484	176665484	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr5:176665484G>C	ENST00000439151.2	+	7	4213	c.4168G>C	c.(4168-4170)Gag>Cag	p.E1390Q	NSD1_ENST00000347982.4_Missense_Mutation_p.E1121Q|NSD1_ENST00000361032.4_Missense_Mutation_p.E1287Q|NSD1_ENST00000354179.4_Missense_Mutation_p.E1121Q	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1390					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		CCTTGAGTCTGAGGAATTGCT	0.507000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			23	71					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238296565	238296565	+	Silent	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:238296565G>A	ENST00000295550.4	-	4	1424	c.972C>T	c.(970-972)ctC>ctT	p.L324L	COL6A3_ENST00000472056.1_Intron|COL6A3_ENST00000392003.2_Intron|COL6A3_ENST00000409809.1_Silent_p.L118L|COL6A3_ENST00000353578.4_Silent_p.L118L|COL6A3_ENST00000346358.4_Silent_p.L324L|COL6A3_ENST00000347401.3_Intron|COL6A3_ENST00000392004.3_Silent_p.L118L	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	324	Nonhelical region.|VWFA 2.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		AATCAAGGGCGAGGCCGATAT	0.617000													7	41					0	0	1	0	0
VIL1	7429	broad.mit.edu	37	2	219292748	219292748	+	Silent	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:219292748C>T	ENST00000248444.5	+	5	496	c.408C>T	c.(406-408)gtC>gtT	p.V136V	VIL1_ENST00000440053.1_Silent_p.V136V|VIL1_ENST00000392114.2_Intron	NM_007127.2	NP_009058.2	P09327	VILI_HUMAN	villin 1	136	Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTATGACGTCCAGAGGCTGC	0.622000													19	146					0	0	1	0	0
ELOVL5	60481	broad.mit.edu	37	6	53160459	53160459	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr6:53160459C>G	ENST00000542638.1	-	2	486	c.39G>C	c.(37-39)aaG>aaC	p.K13N	ELOVL5_ENST00000541407.1_Missense_Mutation_p.K13N|ELOVL5_ENST00000370913.5_Missense_Mutation_p.K13N|ELOVL5_ENST00000304434.6_Missense_Mutation_p.K13N|ELOVL5_ENST00000486973.1_5'UTR|ELOVL5_ENST00000370918.4_Missense_Mutation_p.K13N			Q9NYP7	ELOV5_HUMAN	ELOVL fatty acid elongase 5	13					fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)	7	Lung NSC(77;0.116)					CTAGCAATGCCTTGAAATAGG	0.363000													3	11					0	0	1	0	0
TREML3P	340206	broad.mit.edu	37	6	41185458	41185458	+	RNA	SNP	A	A	C	rs9367097	by1000genomes	TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr6:41185458A>C	ENST00000564680.1	-	0	227																											TGTAGATTTCACACCAGTAGG	0.448000													4	23					0	0	1	0	0
MRPL3	11222	broad.mit.edu	37	3	131190094	131190094	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr3:131190094T>C	ENST00000264995.3	-	7	806	c.659A>G	c.(658-660)aAa>aGa	p.K220R	MRPL3_ENST00000425847.2_Missense_Mutation_p.K247R	NM_007208.3	NP_009139.1	P09001	RM03_HUMAN	mitochondrial ribosomal protein L3	220					translation	mitochondrial large ribosomal subunit	RNA binding|structural constituent of ribosome			endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	10						TCCCCATCTTTTCATGACACC	0.408000													9	83					0	0	1	0	0
CELSR2	1952	broad.mit.edu	37	1	109793320	109793320	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:109793320G>C	ENST00000271332.3	+	1	680	c.619G>C	c.(619-621)Gac>Cac	p.D207H		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	207	Cadherin 1.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GAGGGCCATCGACCCGGACGA	0.617000													5	59					0	0	1	0	0
PRX	57716	broad.mit.edu	37	19	40902543	40902543	+	Silent	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr19:40902543C>T	ENST00000324001.7	-	7	1986	c.1716G>A	c.(1714-1716)gtG>gtA	p.V572V	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	572	55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TCGGCAGCTGCACCTCTGGAA	0.552000													13	225					0	0	1	0	0
EMP2	2013	broad.mit.edu	37	16	10631801	10631801	+	Silent	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr16:10631801G>A	ENST00000359543.3	-	4	509	c.300C>T	c.(298-300)atC>atT	p.I100I	EMP2_ENST00000536829.1_Silent_p.I100I	NM_001424.4	NP_001415.1	P54851	EMP2_HUMAN	epithelial membrane protein 2	100					cell proliferation	integral to membrane				NS(1)|endometrium(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	6						TTAGCTGGATGATGGAGGTTA	0.542000													22	79					0	0	1	0	0
PIP5K1C	23396	broad.mit.edu	37	19	3642935	3642935	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr19:3642935C>T	ENST00000335312.3	-	14	1740	c.1652G>A	c.(1651-1653)cGg>cAg	p.R551Q	PIP5K1C_ENST00000589578.1_Missense_Mutation_p.R551Q|PIP5K1C_ENST00000537021.1_Missense_Mutation_p.R551Q|PIP5K1C_ENST00000539785.1_Missense_Mutation_p.R551Q	NM_001195733.1|NM_012398.2	NP_001182662.1|NP_036530.1	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	551					axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding	p.R551L(1)		large_intestine(3)|ovary(1)|skin(3)|stomach(2)	9		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		CTGTGTGCGCCGCCTGCAGAG	0.637000													11	80					0	0	1	0	0
NCOA2	10499	broad.mit.edu	37	8	71126156	71126156	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr8:71126156G>A	ENST00000452400.2	-	4	422	c.241C>T	c.(241-243)Cgt>Tgt	p.R81C		NM_006540.2	NP_006531.1	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	81					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)|HEY1/NCOA2(10)	NS(1)|breast(4)|endometrium(7)|kidney(4)|large_intestine(10)|lung(25)|ovary(1)|pancreas(2)|prostate(2)|skin(4)	60	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			TTGATCTGACGAATTTGCTTC	0.343000			T	"""RUNXBP2, HEY1"""	"""AML, Chondrosarcoma"""								10	21					0	0	1	0	0
UBE2J1	51465	broad.mit.edu	37	6	90053459	90053459	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr6:90053459C>T	ENST00000435041.2	-	2	326	c.48G>A	c.(46-48)atG>atA	p.M16I		NM_016021.2	NP_057105.2	Q9Y385	UB2J1_HUMAN	ubiquitin-conjugating enzyme E2, J1	16						endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity			NS(1)|breast(2)|kidney(1)|large_intestine(2)|lung(11)|stomach(1)	18		all_cancers(76;1.65e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;2.5e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0139)		CCGCTTCTTTCATTAAACGTT	0.299000													4	32					0	0	1	0	0
SLC6A20	54716	broad.mit.edu	37	3	45800507	45800507	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr3:45800507C>T	ENST00000358525.4	-	11	1857	c.1742G>A	c.(1741-1743)cGt>cAt	p.R581H	SLC6A20_ENST00000456124.2_Intron|SLC6A20_ENST00000353278.4_Missense_Mutation_p.R544H	NM_020208.3	NP_064593.1	Q9NP91	S6A20_HUMAN	solute carrier family 6 (proline IMINO transporter), member 20	581					cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(1)|large_intestine(6)|ovary(2)|skin(2)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		CTTGAGGCGACGCTGAACAAA	0.602000													13	43					0	0	1	0	0
SMC2	10592	broad.mit.edu	37	9	106900437	106900437	+	Silent	SNP	A	A	G			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr9:106900437A>G	ENST00000286398.7	+	24	3696	c.3408A>G	c.(3406-3408)acA>acG	p.T1136T	SMC2_ENST00000374787.3_Silent_p.T1136T|SMC2_ENST00000374793.3_Silent_p.T1136T	NM_001042551.1|NM_001265602.1|NM_006444.2	NP_001036016.1|NP_001252531.1|NP_006435.2	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	1136					cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(14)|ovary(5)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	48						CTCATTTCACACATTCTCAGG	0.343000													22	39					0	0	1	0	0
PMF1	11243	broad.mit.edu	37	1	156203509	156203509	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:156203509G>A	ENST00000368277.3	+	3	367	c.358G>A	c.(358-360)Gag>Aag	p.E120K	PMF1_ENST00000368273.4_Missense_Mutation_p.E122K|PMF1_ENST00000368279.3_Missense_Mutation_p.E120K|PMF1-BGLAP_ENST00000368276.4_Missense_Mutation_p.E120K|PMF1-BGLAP_ENST00000490491.1_Missense_Mutation_p.E120K|PMF1_ENST00000567140.1_Missense_Mutation_p.E120K|PMF1-BGLAP_ENST00000320139.5_Missense_Mutation_p.E120K|PMF1_ENST00000565805.1_Missense_Mutation_p.E120K	NM_007221.3	NP_009152.2			polyamine-modulated factor 1											kidney(1)|large_intestine(2)|lung(3)	6	Hepatocellular(266;0.158)					AGTCCGCAAAGAGCCAGCCTG	0.458000													6	121					0	0	1	0	0
QARS	5859	broad.mit.edu	37	3	49136834	49136834	+	Silent	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr3:49136834G>A	ENST00000306125.6	-	17	1894	c.1557C>T	c.(1555-1557)ctC>ctT	p.L519L	QARS_ENST00000414533.1_Silent_p.L508L			P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	519					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			breast(1)|endometrium(1)|large_intestine(9)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	GCAGGGCCGTGAGTGTAAAGA	0.557000													10	70					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3788618	3788618	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr16:3788618G>A	ENST00000262367.5	-	26	5145	c.4336C>T	c.(4336-4338)Cgc>Tgc	p.R1446C	CREBBP_ENST00000382070.3_Missense_Mutation_p.R1408C	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1446	Cys/His-rich.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding	p.R1446C(6)|p.R1446G(1)		NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		ACGGCTGTGCGGAGGCAACGT	0.413000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						5	21					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12460316	12460316	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:12460316G>A	ENST00000358136.3	+	61	11843	c.11713G>A	c.(11713-11715)Gag>Aag	p.E3905K	VPS13D_ENST00000356315.4_Missense_Mutation_p.E3880K|VPS13D_ENST00000496628.1_3'UTR	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	3904					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TGAGGTCATCGAGACCGGCCC	0.552000													14	32					0	0	1	0	0
MAMDC4	158056	broad.mit.edu	37	9	139752992	139752992	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr9:139752992G>A	ENST00000445819.1	+	24	3102	c.3052G>A	c.(3052-3054)Gag>Aag	p.E1018K	MAMDC4_ENST00000485732.1_3'UTR|MAMDC4_ENST00000317446.2_Missense_Mutation_p.E939K			Q6UXC1	AEGP_HUMAN	MAM domain containing 4	1018	MAM 6.				protein transport	integral to membrane				breast(4)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	19	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		CCTGGGCACAGAGGCAGGTAC	0.706000													3	12					0	0	1	0	0
NTRK1	4914	broad.mit.edu	37	1	156845927	156845927	+	Silent	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:156845927C>T	ENST00000368196.3	+	12	1659	c.1539C>T	c.(1537-1539)ggC>ggT	p.G513G	NTRK1_ENST00000524377.1_Silent_p.G519G|NTRK1_ENST00000392302.2_Silent_p.G483G|NTRK1_ENST00000358660.3_Silent_p.G516G	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	519	Protein kinase.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	TGGGGGAGGGCGCCTTTGGGA	0.632000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			5	69					0	0	1	0	0
OMP	4975	broad.mit.edu	37	11	76814355	76814355	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr11:76814355C>T	ENST00000529803.1	+	1	470	c.470C>T	c.(469-471)tCc>tTc	p.S157F	CAPN5_ENST00000531028.1_Intron|CAPN5_ENST00000529629.1_Intron|CAPN5_ENST00000456580.2_Intron|CAPN5_ENST00000278559.3_Intron	NM_006189.1	NP_006180.1	P47874	OMP_HUMAN	olfactory marker protein	157					sensory perception of smell|synaptic transmission					endometrium(1)|kidney(1)|large_intestine(2)|lung(1)	5						CTCAAGGCCTCCGTGGTTTTT	0.602000													11	76					0	0	1	0	0
DYNC2LI1	51626	broad.mit.edu	37	2	44023913	44023913	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:44023913T>G	ENST00000260605.8	+	8	733	c.633T>G	c.(631-633)caT>caG	p.H211Q	DYNC2LI1_ENST00000489222.2_3'UTR|DYNC2LI1_ENST00000443170.3_Missense_Mutation_p.H85Q|DYNC2LI1_ENST00000605786.1_Missense_Mutation_p.H212Q	NM_001193464.1|NM_016008.3	NP_001180393.1|NP_057092.2	Q8TCX1	DC2L1_HUMAN	dynein, cytoplasmic 2, light intermediate chain 1	211						apical part of cell|axonemal dynein complex|cilium axoneme|cytoplasm|microtubule|motile primary cilium	motor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|skin(1)	26		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TTGTTGCACATTATTATGGAG	0.353000													15	59					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577099	7577099	+	Missense_Mutation	SNP	C	C	G	rs121912660		TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr17:7577099C>G	ENST00000420246.2	-	8	971	c.839G>C	c.(838-840)aGa>aCa	p.R280T	TP53_ENST00000413465.2_Intron|TP53_ENST00000455263.2_Missense_Mutation_p.R280T|TP53_ENST00000445888.2_Missense_Mutation_p.R280T|TP53_ENST00000359597.4_Missense_Mutation_p.R280T|TP53_ENST00000269305.4_Missense_Mutation_p.R280T	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	280	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		R -> G (in sporadic cancers; somatic mutation).|R -> I (in sporadic cancers; somatic mutation).|R -> K (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in a sporadic cancer; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R280T(65)|p.R280K(49)|p.R280I(16)|p.0?(8)|p.?(2)|p.R280_D281delRD(2)|p.A276_R283delACPGRDRR(1)|p.C275fs*20(1)|p.A276fs*64(1)|p.L265_K305del41(1)|p.G279_R280delGR(1)|p.F270_D281del12(1)|p.G279fs*59(1)|p.D281fs*24(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.V272_K292del21(1)|p.C275_R283delCACPGRDRR(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCGCCGGTCTCTCCCAGGACA	0.542000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			13	25					0	0	1	0	0
CKAP5	9793	broad.mit.edu	37	11	46786765	46786765	+	Silent	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr11:46786765C>T	ENST00000529230.1	-	28	3499	c.3453G>A	c.(3451-3453)aaG>aaA	p.K1151K	CKAP5_ENST00000354558.3_Silent_p.K1151K|CKAP5_ENST00000415402.1_Silent_p.K1151K|CKAP5_ENST00000312055.5_Silent_p.K1151K			Q14008	CKAP5_HUMAN	cytoskeleton associated protein 5	1151					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding			breast(1)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	43						CTTCATCCTCCTTTAAGCTGG	0.398000													27	81					0	0	1	0	0
MFRP	83552	broad.mit.edu	37	11	119216543	119216543	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr11:119216543G>C	ENST00000555262.1	-	4	526	c.367C>G	c.(367-369)Cag>Gag	p.Q123E	C1QTNF5_ENST00000445041.2_5'UTR|MFRP_ENST00000529147.1_5'UTR|MFRP_ENST00000449574.2_Missense_Mutation_p.Q123E|MFRP_ENST00000530681.1_Missense_Mutation_p.Q123E|MFRP_ENST00000360167.4_Missense_Mutation_p.Q123E	NM_001278431.1	NP_001265360.1			membrane frizzled-related protein											autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)|urinary_tract(1)	18		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		CCAGCTGCCTGAGAggtggtg	0.662000													10	60					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7576886	7576886	+	Silent	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr17:7576886C>T	ENST00000420246.2	-	9	1092	c.960G>A	c.(958-960)aaG>aaA	p.K320K	TP53_ENST00000413465.2_Intron|TP53_ENST00000455263.2_Silent_p.K320K|TP53_ENST00000445888.2_Silent_p.K320K|TP53_ENST00000359597.4_Silent_p.K320K|TP53_ENST00000269305.4_Silent_p.K320K	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	320	Interaction with CARM1.|Interaction with HIPK1 (By similarity).|Interaction with HIPK2.		K -> N (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.K320N(3)|p.P318fs*15(2)|p.P318fs*21(1)|p.S315fs*22(1)|p.?(1)|p.L308fs*15(1)|p.K320K(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCAGTGGTTTCTTCTTTGGCT	0.458000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			26	41					0	0	1	0	0
PPP1R1B	84152	broad.mit.edu	37	17	37790282	37790282	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr17:37790282G>C	ENST00000254079.4	+	5	857	c.388G>C	c.(388-390)Gaa>Caa	p.E130Q	PPP1R1B_ENST00000394265.1_Missense_Mutation_p.E94Q|PPP1R1B_ENST00000579000.1_Missense_Mutation_p.E97Q|PPP1R1B_ENST00000580825.1_Missense_Mutation_p.E130Q|PPP1R1B_ENST00000394267.2_Missense_Mutation_p.E94Q	NM_032192.3	NP_115568.2	Q9UD71	PPR1B_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 1B	130	Asp/Glu-rich (acidic).				signal transduction	cytosol	protein kinase inhibitor activity|protein phosphatase inhibitor activity			kidney(1)|large_intestine(1)|liver(1)|lung(2)	5	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;1.04e-44)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			ggatgatgaagaagaggaaga	0.547000													13	103					0	0	1	0	0
MUC15	143662	broad.mit.edu	37	11	26587103	26587103	+	Silent	SNP	T	T	C			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr11:26587103T>C	ENST00000436318.2	-	2	517	c.384A>G	c.(382-384)aaA>aaG	p.K128K	ANO3_ENST00000525139.1_Intron|ANO3_ENST00000537978.1_Intron|ANO3_ENST00000531568.1_Intron|ANO3_ENST00000256737.3_Intron|MUC15_ENST00000527569.1_Silent_p.K128K|MUC15_ENST00000529533.1_Silent_p.K128K|MUC15_ENST00000455601.2_Silent_p.K101K|MUC15_ENST00000281268.8_Silent_p.K128K			Q8N387	MUC15_HUMAN	mucin 15, cell surface associated	101						extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	25						TAGATGTGGGTTTTAGACTGC	0.453000													20	89					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157514227	157514227	+	Silent	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:157514227C>T	ENST00000361835.3	-	5	826	c.669G>A	c.(667-669)ccG>ccA	p.P223P	FCRL5_ENST00000368189.3_Silent_p.P223P|FCRL5_ENST00000368191.3_Silent_p.P138P|FCRL5_ENST00000356953.4_Silent_p.P223P|FCRL5_ENST00000368190.3_Silent_p.P223P	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	223	Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				GGAACCGGAGCGGGACATCTG	0.567000													19	114					0	0	1	0	0
PGM5	5239	broad.mit.edu	37	9	71098912	71098912	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr9:71098912C>T	ENST00000396396.1	+	9	1656	c.1427C>T	c.(1426-1428)aCg>aTg	p.T476M		NM_021965.3	NP_068800.2	Q15124	PGM5_HUMAN	phosphoglucomutase 5	476					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			endometrium(5)|kidney(1)|large_intestine(5)|liver(2)|lung(15)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	34						GTGGCGAAGACGGATAGTTTT	0.502000													17	68					0	0	1	0	0
ACSM5	54988	broad.mit.edu	37	16	20448621	20448621	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr16:20448621G>T	ENST00000331849.4	+	12	1615	c.1468G>T	c.(1468-1470)Gcc>Tcc	p.A490S		NM_017888.2	NP_060358.2	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	490					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(3)|urinary_tract(1)	51						AGTGGAAAGTGCCCTGGCAGA	0.567000													10	63					0.00829132	0.00838773	1	1	0
MFRP	83552	broad.mit.edu	37	11	119216325	119216325	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr11:119216325G>C	ENST00000555262.1	-	5	605	c.446C>G	c.(445-447)tCt>tGt	p.S149C	C1QTNF5_ENST00000445041.2_5'UTR|MFRP_ENST00000529147.1_5'UTR|MFRP_ENST00000449574.2_Missense_Mutation_p.S149C|MFRP_ENST00000530681.1_Missense_Mutation_p.S149C|MFRP_ENST00000360167.4_Missense_Mutation_p.S149C	NM_001278431.1	NP_001265360.1			membrane frizzled-related protein											autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)|urinary_tract(1)	18		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		CCTTGGGCCAGAGAGGAGGCC	0.567000													7	29					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222946	140222946	+	Silent	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr5:140222946G>A	ENST00000531613.1	+	1	2040	c.2040G>A	c.(2038-2040)tcG>tcA	p.S680S	PCDHA5_ENST00000529619.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA8_ENST00000378123.3_Silent_p.S680S|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGCGTCATCGAGGCAGTCGG	0.627000													12	99					0	0	1	0	0
BCAP29	55973	broad.mit.edu	37	7	107253835	107253835	+	Silent	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr7:107253835G>A	ENST00000379119.2	+	6	662	c.648G>A	c.(646-648)tcG>tcA	p.S216S	BCAP29_ENST00000445771.2_Silent_p.S216S|BCAP29_ENST00000379117.2_Silent_p.S216S|BCAP29_ENST00000465919.1_Silent_p.S122S|BCAP29_ENST00000379121.2_Silent_p.S122S|BCAP29_ENST00000005259.4_Silent_p.S216S|BCAP29_ENST00000494086.1_3'UTR	NM_001008405.2	NP_001008405.1	Q9UHQ4	BAP29_HUMAN	B-cell receptor-associated protein 29	216					apoptosis|intracellular protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane				cervix(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	14						AGAGACTTTCGAAAGAATATG	0.333000													10	38					0	0	1	0	0
ANGPTL4	51129	broad.mit.edu	37	19	8429403	8429403	+	Silent	SNP	G	G	C			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr19:8429403G>C	ENST00000301455.2	+	1	369	c.198G>C	c.(196-198)ctG>ctC	p.L66L	ANGPTL4_ENST00000541807.1_5'UTR|ANGPTL4_ENST00000393962.2_Silent_p.L66L	NM_139314.1	NP_647475.1	Q9BY76	ANGL4_HUMAN	angiopoietin-like 4	66				LREHAERTRSQLSALER -> CANTGAHPQSAERAGA (in Ref. 5; AAD41088).	angiogenesis|cell differentiation|cellular lipid metabolic process|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|positive regulation of angiogenesis|response to hypoxia|signal transduction|triglyceride homeostasis	extracellular space|proteinaceous extracellular matrix	enzyme inhibitor activity|receptor binding			large_intestine(1)|lung(1)|ovary(2)|skin(2)	6						GCAGTCAGCTGAGCGCGCTGG	0.716000													3	5					0	0	1	0	0
TRPM7	54822	broad.mit.edu	37	15	50866552	50866552	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr15:50866552T>A	ENST00000313478.7	-	36	5508	c.5227A>T	c.(5227-5229)Act>Tct	p.T1743S	TRPM7_ENST00000560955.1_Missense_Mutation_p.T1742S|TRPM7_ENST00000561443.1_5'UTR	NM_017672.4	NP_060142.3	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel, subfamily M, member 7	1743	Alpha-type protein kinase.				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(17)|lung(13)|ovary(4)|pancreas(1)|skin(4)|stomach(3)	52				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		TCTTCCAGAGTATTAGTTGGA	0.358000													6	88					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109400167	109400167	+	Missense_Mutation	SNP	A	A	G	rs141352150		TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:109400167A>G	ENST00000283195.6	+	29	9611	c.9485A>G	c.(9484-9486)aAt>aGt	p.N3162S		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	3162	PPIase cyclophilin-type.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						TCCATGGCCAATCAAGGCCAG	0.368000													10	88					0	0	1	0	0
ULK2	9706	broad.mit.edu	37	17	19685248	19685248	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr17:19685248C>G	ENST00000395544.4	-	23	3092	c.2593G>C	c.(2593-2595)Gag>Cag	p.E865Q	ULK2_ENST00000361658.2_Missense_Mutation_p.E865Q	NM_014683.3	NP_055498.3	Q8IYT8	ULK2_HUMAN	unc-51 like autophagy activating kinase 2	865					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			large_intestine(1)|skin(4)|stomach(1)	6	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					ACCACACTCTCCTGGATCTGG	0.522000													13	102					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152282251	152282251	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:152282251G>C	ENST00000368799.1	-	3	5146	c.5111C>G	c.(5110-5112)tCt>tGt	p.S1704C	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1704	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCGACTACAGATGAATCTTG	0.572000									Ichthyosis				30	349					0	0	1	0	0
SECISBP2L	9728	broad.mit.edu	37	15	49329879	49329879	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr15:49329879C>T	ENST00000559471.1	-	2	375	c.112G>A	c.(112-114)Gat>Aat	p.D38N	SECISBP2L_ENST00000261847.3_Missense_Mutation_p.D38N	NM_001193489.1	NP_001180418.1	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	38										breast(1)|endometrium(5)|kidney(8)|large_intestine(12)|lung(11)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|urinary_tract(1)	46						CTTCCATTATCATTTGGGAGA	0.423000													5	32					0	0	1	0	0
CYFIP1	23191	broad.mit.edu	37	15	22929892	22929892	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr15:22929892A>G	ENST00000313077.7	+	6	691	c.566A>G	c.(565-567)aAg>aGg	p.K189R	CYFIP1_ENST00000560848.1_Missense_Mutation_p.K189R	NM_014608.2	NP_055423.1	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1	189					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(1)|lung(14)|ovary(4)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	40		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		TCAGCGTACAAGAGGTGAGCA	0.567000													8	26					0	0	1	0	0
PAX3	5077	broad.mit.edu	37	2	223096999	223096999	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:223096999G>A	ENST00000350526.4	-	5	726	c.590C>T	c.(589-591)tCa>tTa	p.S197L	PAX3_ENST00000392069.2_Missense_Mutation_p.S197L|PAX3_ENST00000344493.4_Missense_Mutation_p.S197L|PAX3_ENST00000409551.3_Missense_Mutation_p.S196L|PAX3_ENST00000336840.6_Missense_Mutation_p.S197L|PAX3_ENST00000392070.2_Missense_Mutation_p.S197L	NM_181457.3	NP_852122.1	P23760	PAX3_HUMAN	paired box 3	197					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/NCOA2(4)|PAX3/NCOA1(8)|PAX3/FOXO1(749)	NS(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(13)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	38		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTGGGGTGCTGAGGCTAAAAG	0.413000			T	"""FOXO1A, NCOA1"""	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						10	92					0	0	1	0	0
TRIL	9865	broad.mit.edu	37	7	28996417	28996417	+	RNA	SNP	C	C	T			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr7:28996417C>T	ENST00000322982.3	-	0	1517							Q7L0X0	TRIL_HUMAN	TLR4 interactor with leucine-rich repeats						inflammatory response|innate immune response|regulation of cytokine production involved in immune response|toll-like receptor 4 signaling pathway	lipopolysaccharide receptor complex	lipopolysaccharide binding										GGCGAGGGATCCGCGCAGGAT	0.662000													15	42					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27101322	27101326	+	Frame_Shift_Del	DEL	CAGAT	CAGAT	-			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:27101322_27101326delCAGAT	ENST00000324856.7	+	18	4975_4979	c.4604_4608delCAGAT	c.(4603-4608)acagatfs	p.TD1535fs	ARID1A_ENST00000540690.1_Intron|ARID1A_ENST00000457599.2_Intron|ARID1A_ENST00000374152.2_Frame_Shift_Del_p.TD1152fs	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1535					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		ATGCTGCACACAGATCAGAGGGCCA	0.605			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								13	76	---	---	---	---					
ZZZ3	26009	broad.mit.edu	37	1	78098224	78098224	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:78098224delT	ENST00000370801.3	-	5	1291	c.816delA	c.(814-816)caafs	p.Q272fs	ZZZ3_ENST00000370798.1_Intron|ZZZ3_ENST00000476275.1_5'UTR	NM_015534.4	NP_056349.1	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	272					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(1)|stomach(1)|urinary_tract(2)	39						TGACCTGCACTTGTGAATCTG	0.458													37	246	---	---	---	---					
RP11-353N4.5	0	broad.mit.edu	37	1	149649078	149649079	+	RNA	INS	-	-	A	rs140263023		TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr1:149649078_149649079insA	ENST00000608683.1	-	0	533_534																											AGAGAGCCTTCAAAACCTCTTA	0.426													8	23	---	---	---	---					
SMC6	79677	broad.mit.edu	37	2	17898126	17898126	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:17898126delT	ENST00000448223.2	-	14	1497	c.1228delA	c.(1228-1230)atafs	p.I410fs	SMC6_ENST00000381272.4_Frame_Shift_Del_p.I436fs|SMC6_ENST00000351948.4_Frame_Shift_Del_p.I410fs|SMC6_ENST00000402989.1_Frame_Shift_Del_p.I410fs	NM_001142286.1	NP_001135758.1	Q96SB8	SMC6_HUMAN	structural maintenance of chromosomes 6	410					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			NS(1)|biliary_tract(1)|breast(6)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	43	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					AACCAAGATATTTTTTTTTGT	0.343													7	116	---	---	---	---					
SDC1	6382	broad.mit.edu	37	2	20405159	20405160	+	Frame_Shift_Ins	INS	-	-	G			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr2:20405159_20405160insG	ENST00000381150.1	-	3	482_483	c.92_93insC	c.(91-93)cctfs	p.P31fs	SDC1_ENST00000482879.1_5'UTR|SDC1_ENST00000403076.1_Frame_Shift_Ins_p.P31fs|SDC1_ENST00000254351.4_Frame_Shift_Ins_p.P31fs	NM_001006946.1	NP_001006947	P18827	SDC1_HUMAN	syndecan 1	31					lipid metabolic process|lipoprotein metabolic process|myoblast development|striated muscle cell development	cytoplasm|extracellular region|focal adhesion|integral to plasma membrane	cytoskeletal protein binding|protein C-terminus binding			NS(1)|breast(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(4)|skin(2)	21	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)			OV - Ovarian serous cystadenocarcinoma(76;0.221)		CTTGATCTTCAGGGGGCAAATT	0.550													7	106	---	---	---	---					
RARB	5915	broad.mit.edu	37	3	25216052	25216053	+	Frame_Shift_Del	DEL	CC	CC	-			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr3:25216052_25216053delCC	ENST00000404969.1	+	1	164_165	c.164_165delCC	c.(163-165)accfs	p.T55fs				P10826	RARB_HUMAN	retinoic acid receptor, beta	55	Modulating.				embryonic digestive tract development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	protein binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|kidney(1)|large_intestine(10)|lung(11)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	28					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tamibarotene(DB04942)|Tazarotene(DB00799)	GGATGCAGCACCCCGTCGCCGG	0.559													13	42	---	---	---	---					
ALS2CL	259173	broad.mit.edu	37	3	46714826	46714827	+	Splice_Site	DEL	CA	CA	-			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr3:46714826_46714827delCA	ENST00000318962.4	-	22	2556		c.e22+1		ALS2CL_ENST00000383742.3_Splice_Site|ALS2CL_ENST00000415953.1_Splice_Site	NM_147129.3	NP_667340.2	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like						endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(3)|stomach(2)	29				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		GCCTCCCTCTCACCTGATTGCT	0.609													2	4	---	---	---	---					
CTC-338M12.9	0	broad.mit.edu	37	5	180708776	180708777	+	RNA	INS	-	-	G	rs140221514		TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr5:180708776_180708777insG	ENST00000412295.2	+	0	238																											gggcggtaggagggggctggag	0.728													2	4	---	---	---	---					
BTN2A3P	54718	broad.mit.edu	37	6	26430817	26430817	+	RNA	DEL	A	A	-	rs143133904		TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr6:26430817delA	ENST00000466808.2	+	0	1447																											gctcagtctcaaaaaaaaaaa	0.537													3	3	---	---	---	---					
AZGP1P1	646282	broad.mit.edu	37	7	99578706	99578706	+	RNA	DEL	A	A	-			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr7:99578706delA	ENST00000425474.1	+	0	87					NR_036679.1																						cttagtttacagtgaaaacaa	0.522													2	4	---	---	---	---					
PNLIPRP2	5408	broad.mit.edu	37	10	118396277	118396278	+	RNA	INS	-	-	T	rs148140777	by1000genomes	TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr10:118396277_118396278insT	ENST00000537242.1	+	0	962				PNLIPRP2_ENST00000433618.4_RNA|PNLIPRP2_ENST00000298771.7_RNA	NM_005396.4	NP_005387.2	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			endometrium(1)|large_intestine(1)|lung(11)|prostate(3)	16				all cancers(201;0.015)		GACAAATTATGGTTTTTTTTTT	0.421													6	4	---	---	---	---					
TACC2	10579	broad.mit.edu	37	10	123844356	123844356	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr10:123844356delC	ENST00000369005.1	+	4	2681	c.2341delC	c.(2341-2343)cccfs	p.P782fs	TACC2_ENST00000515603.1_Frame_Shift_Del_p.P782fs|TACC2_ENST00000453444.2_Frame_Shift_Del_p.P782fs|TACC2_ENST00000513429.1_Intron|TACC2_ENST00000358010.1_Intron|TACC2_ENST00000334433.3_Frame_Shift_Del_p.P782fs|TACC2_ENST00000515273.1_Frame_Shift_Del_p.P782fs	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	782						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GGTGCCACATCCCCCCCAGGG	0.642													10	93	---	---	---	---					
DNAH3	55567	broad.mit.edu	37	16	20952843	20952844	+	Frame_Shift_Ins	INS	-	-	G			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr16:20952843_20952844insG	ENST00000261383.3	-	59	11532_11533	c.11533_11534insC	c.(11533-11535)caafs	p.Q3845fs	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3845					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GAGAATGTCTTGTGCCAACTCC	0.475													36	124	---	---	---	---					
CTB-186H2.2	0	broad.mit.edu	37	17	34292045	34292046	+	RNA	INS	-	-	AAAAAAAAAAA			TCGA-FD-A3SP-01A-31D-A22Z-08	TCGA-FD-A3SP-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d838ad09-33b5-4ead-b405-6ce558a5ed59	14d4450c-5966-46b9-91fe-d4b745a678ff	g.chr17:34292045_34292046insAAAAAAAAAAA	ENST00000586205.1	-	0	283																											gactccgtttcaaaaaaaaaaa	0.441													5	5	---	---	---	---					
