Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TMEM37	140738	broad.mit.edu	37	2	120194538	120194538	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr2:120194538C>T	ENST00000306406.4	+	2	130	c.95C>T	c.(94-96)aCg>aTg	p.T32M	TMEM37_ENST00000465296.1_3'UTR|TMEM37_ENST00000409826.1_Missense_Mutation_p.T44M	NM_183240.2	NP_899063.2	Q8WXS4	CCGL_HUMAN	transmembrane protein 37	32						integral to membrane	calcium channel activity|voltage-gated ion channel activity	p.T32M(1)		breast(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	11						CTCATCATCACGTGTGTGGCC	0.612000													14	186					0	0	1	0	0
ANKRD23	200539	broad.mit.edu	37	2	97505287	97505287	+	Silent	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr2:97505287C>T	ENST00000318357.4	-	9	958	c.917G>A	c.(916-918)tGa>tAa	p.*306*	ANKRD23_ENST00000476975.1_Intron|ANKRD23_ENST00000418232.1_Silent_p.*306*|ANKRD23_ENST00000331001.2_Silent_p.*264*	NM_144994.7	NP_659431.5	Q86SG2	ANR23_HUMAN	ankyrin repeat domain 23	0						nucleus				endometrium(2)|kidney(1)|lung(4)|ovary(1)|prostate(1)	9						GTGCTGCGGTCAGCACCGGGT	0.736000													11	16					0	0	1	0	0
CCDC129	223075	broad.mit.edu	37	7	31683271	31683271	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr7:31683271C>A	ENST00000319386.3	+	11	2836	c.1843C>A	c.(1843-1845)Cag>Aag	p.Q615K	CCDC129_ENST00000409210.1_Missense_Mutation_p.Q671K|CCDC129_ENST00000407970.3_Missense_Mutation_p.Q763K|CCDC129_ENST00000451887.2_Missense_Mutation_p.Q789K			Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	763										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						TGCTTCCATTCAGACTTCAGC	0.483000													6	115					0.00116845	0.00122305	1	1	0
HYDIN	54768	broad.mit.edu	37	16	71026037	71026037	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr16:71026037C>A	ENST00000393567.2	-	24	3871	c.3721G>T	c.(3721-3723)Gcc>Tcc	p.A1241S	HYDIN_ENST00000448089.2_Missense_Mutation_p.A1193S	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	1241										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				GGTGGGCTGGCAGCCTCTGAG	0.483000													8	91					2.17888e-05	2.41618e-05	1	1	0
EPS15	2060	broad.mit.edu	37	1	51873977	51873977	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr1:51873977T>A	ENST00000371733.3	-	15	1399	c.1303A>T	c.(1303-1305)Agt>Tgt	p.S435C	EPS15_ENST00000493793.1_5'UTR|EPS15_ENST00000371730.2_Intron|EPS15_ENST00000396122.4_Missense_Mutation_p.S112C	NM_001981.2	NP_001972.1	P42566	EPS15_HUMAN	epidermal growth factor receptor pathway substrate 15	435					cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding	p.0?(2)		endometrium(3)|kidney(5)|large_intestine(8)|lung(13)|prostate(2)|skin(1)|stomach(1)|urinary_tract(2)	35						GATTCCTGACTAGTTAATTCA	0.388000			T	MLL	ALL								13	64					0	0	1	0	0
DCBLD1	285761	broad.mit.edu	37	6	117861847	117861847	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr6:117861847C>T	ENST00000338728.5	+	10	1238	c.1118C>T	c.(1117-1119)tCt>tTt	p.S373F	DCBLD1_ENST00000534777.1_3'UTR|GOPC_ENST00000467125.1_Intron|DCBLD1_ENST00000296955.8_Missense_Mutation_p.S373F|DCBLD1_ENST00000368503.4_Intron			Q8N8Z6	DCBD1_HUMAN	discoidin, CUB and LCCL domain containing 1	373	F5/8 type C.				cell adhesion	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(15)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	26		all_cancers(87;0.171)		GBM - Glioblastoma multiforme(226;0.0447)|OV - Ovarian serous cystadenocarcinoma(136;0.0921)|all cancers(137;0.125)		CAGGGTAACTCTAACTTTCGG	0.428000													12	113					0	0	1	0	0
TTC21A	199223	broad.mit.edu	37	3	39174683	39174683	+	Silent	SNP	G	G	T	rs35645810		TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr3:39174683G>T	ENST00000301819.6	+	20	2904	c.2727G>T	c.(2725-2727)gcG>gcT	p.A909A	TTC21A_ENST00000493856.1_3'UTR|TTC21A_ENST00000431162.2_Silent_p.A908A|TTC21A_ENST00000440121.1_Silent_p.A860A	NM_145755.2	NP_665698.2	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A	908							binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(23)|ovary(1)|prostate(1)|skin(3)	50				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		ATGACAAGGCGGTACAGTCTT	0.493000													19	61					3.51602e-12	4.1893e-12	1	1	0
KCNB2	9312	broad.mit.edu	37	8	73848282	73848282	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr8:73848282G>A	ENST00000523207.1	+	3	1280	c.692G>A	c.(691-693)cGc>cAc	p.R231H		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	231					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			AATGACAACCGCCAATTAGCA	0.458000													10	169					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713773	142713773	+	RNA	SNP	C	C	G			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr1:142713773C>G	ENST00000610091.1	-	0	1885																											TCTTTTTCCACATTGTCATTT	0.284000													5	34					0	0	1	0	0
CYCS	54205	broad.mit.edu	37	7	25163680	25163680	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr7:25163680G>T	ENST00000305786.2	-	2	228	c.59C>A	c.(58-60)aCc>aAc	p.T20N	CYCS_ENST00000409409.1_Missense_Mutation_p.T20N|CYCS_ENST00000409764.1_Missense_Mutation_p.T20N	NM_018947.5	NP_061820.1	P99999	CYC_HUMAN	cytochrome c, somatic	20					activation of caspase activity by cytochrome c|DNA fragmentation involved in apoptotic nuclear change|induction of apoptosis by intracellular signals|respiratory electron transport chain|transport	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial matrix|nucleus|protein phosphatase type 2A complex|respiratory chain	electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity|heme binding|protein binding			endometrium(1)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	4					Melatonin(DB01065)|Minocycline(DB01017)	CTTTTCAACGGTGTGGCACTG	0.438000													12	51					6.40141e-05	7.029e-05	1	1	0
OR4D9	390199	broad.mit.edu	37	11	59282718	59282718	+	Silent	SNP	C	C	T	rs149287111	byFrequency	TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr11:59282718C>T	ENST00000329328.3	+	1	333	c.333C>T	c.(331-333)gaC>gaT	p.D111D		NM_001004711.1	NP_001004711.1	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D, member 9	111					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|prostate(5)|upper_aerodigestive_tract(1)	26						GGGGAGCAGACGTTTTTTCTC	0.493000													6	123					0	0	1	0	0
CAND1	55832	broad.mit.edu	37	12	67686475	67686475	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr12:67686475C>G	ENST00000545606.1	+	3	723	c.286C>G	c.(286-288)Ctt>Gtt	p.L96V		NM_018448.3	NP_060918.2	Q86VP6	CAND1_HUMAN	cullin-associated and neddylation-dissociated 1	96					cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)	35			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		CACTAACATGCTTTCTGATAA	0.358000													8	39					0	0	1	0	0
NUP214	8021	broad.mit.edu	37	9	134003022	134003022	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr9:134003022G>A	ENST00000359428.5	+	2	301	c.157G>A	c.(157-159)Gct>Act	p.A53T	NUP214_ENST00000411637.2_Missense_Mutation_p.A53T|NUP214_ENST00000451030.1_Missense_Mutation_p.A53T			P35658	NU214_HUMAN	nucleoporin 214kDa	53					carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		TCTGGTCTTCGCTGGTGGAGC	0.448000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								11	150					0	0	1	0	0
AIFM1	9131	broad.mit.edu	37	X	129281476	129281476	+	Silent	SNP	T	T	C	rs143670174		TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chrX:129281476T>C	ENST00000287295.3	-	5	827	c.597A>G	c.(595-597)aaA>aaG	p.K199K	AIFM1_ENST00000346424.2_Intron|AIFM1_ENST00000319908.3_Silent_p.K195K|AIFM1_ENST00000535724.1_Silent_p.K112K	NM_001130847.3|NM_004208.3	NP_001124319.1|NP_004199.1	O95831	AIFM1_HUMAN	apoptosis-inducing factor, mitochondrion-associated, 1	199	FAD-dependent oxidoreductase (By similarity).				activation of caspase activity|apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|nucleus|perinuclear region of cytoplasm	DNA binding|electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|liver(2)|lung(8)|ovary(4)|prostate(2)|urinary_tract(1)	30						ACCTTCTCTCTTTTCCATTCC	0.423000													4	50					0	0	1	0	0
KANSL3	55683	broad.mit.edu	37	2	97274330	97274330	+	Silent	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr2:97274330C>T	ENST00000599854.1	-	14	1862	c.1395G>A	c.(1393-1395)caG>caA	p.Q465Q	KANSL3_ENST00000441706.2_Silent_p.Q465Q|KANSL3_ENST00000487070.1_5'UTR|KANSL3_ENST00000440133.1_Silent_p.Q346Q|KANSL3_ENST00000431828.1_Silent_p.Q552Q	NM_001115016.2	NP_001108488.1	Q9P2N6	K1310_HUMAN	KAT8 regulatory NSL complex subunit 3	552																	GACTGGACTTCTGGGCAGAGG	0.532000													23	97					0	0	1	0	0
TSSC2	650368	broad.mit.edu	37	11	3427765	3427765	+	RNA	SNP	G	G	C			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr11:3427765G>C	ENST00000529482.1	+	0	882																											CACACGTCCTGCAGTGGCCTG	0.602000													3	69					0	0	1	0	0
MYH9	4627	broad.mit.edu	37	22	36710274	36710274	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr22:36710274C>G	ENST00000216181.5	-	13	1700	c.1470G>C	c.(1468-1470)gaG>gaC	p.E490D		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	490	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						GCTGGTACTCCTCCTGCTCCA	0.542000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				7	109					0	0	1	0	0
HPS3	84343	broad.mit.edu	37	3	148847537	148847537	+	Silent	SNP	G	G	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr3:148847537G>A	ENST00000296051.2	+	1	167	c.27G>A	c.(25-27)ccG>ccA	p.P9P	HPS3_ENST00000460120.1_Silent_p.P9P|HPS3_ENST00000494327.1_3'UTR	NM_032383.3	NP_115759.2	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3	9						cytoplasm				breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	34			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			ACCTGCACCCGTTCGGGTCGC	0.716000									Hermansky-Pudlak syndrome				7	45					0	0	1	0	0
PRKRA	8575	broad.mit.edu	37	2	179308096	179308096	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr2:179308096G>T	ENST00000325748.4	-	5	612	c.412C>A	c.(412-414)Cat>Aat	p.H138N	PRKRA_ENST00000432031.2_Missense_Mutation_p.H127N|PRKRA_ENST00000487082.1_Missense_Mutation_p.H113N|PRKRA_ENST00000438687.3_Missense_Mutation_p.H25N	NM_003690.4	NP_003681.1	O75569	PRKRA_HUMAN	protein kinase, interferon-inducible double stranded RNA dependent activator	138	DRBM 2.|Sufficient for self-association and interaction with TARBP2.				immune response|negative regulation of cell proliferation|production of siRNA involved in RNA interference|response to virus	perinuclear region of cytoplasm	double-stranded RNA binding|enzyme activator activity|protein homodimerization activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|skin(2)	19			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.00634)|all cancers(119;0.0265)			CTCCAGCCATGATGAATAGCC	0.368000													4	22					0.014758	0.0150263	1	1	0
CREB3L1	90993	broad.mit.edu	37	11	46333971	46333971	+	Silent	SNP	C	C	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr11:46333971C>A	ENST00000529193.1	+	6	1300	c.849C>A	c.(847-849)ctC>ctA	p.L283L	CREB3L1_ENST00000288400.3_Silent_p.L283L			Q96BA8	CR3L1_HUMAN	cAMP responsive element binding protein 3-like 1	283					response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L1(6)	NS(2)|breast(1)|large_intestine(4)|lung(2)|ovary(3)	12				GBM - Glioblastoma multiforme(35;0.0285)		AACTCCCCCTCACCAAAGCCG	0.567000			T	FUS	myxofibrosarcoma								13	66					0.00185496	0.00192366	1	1	0
C17orf75	64149	broad.mit.edu	37	17	30662407	30662407	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr17:30662407C>T	ENST00000577809.1	-	6	653	c.604G>A	c.(604-606)Gtt>Att	p.V202I	RP11-227G15.3_ENST00000581915.1_RNA|C17orf75_ENST00000225805.4_Missense_Mutation_p.V202I	NM_022344.3	NP_071739.2	Q9HAS0	NJMU_HUMAN	chromosome 17 open reading frame 75	202					spermatogenesis					ovary(1)	1		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			GGGCATACAACATCCTCAAAC	0.408000													35	94					0	0	1	0	0
EVC2	132884	broad.mit.edu	37	4	5578082	5578082	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr4:5578082C>T	ENST00000310917.2	-	18	3648	c.2917G>A	c.(2917-2919)Gat>Aat	p.D973N	EVC2_ENST00000344938.1_Missense_Mutation_p.D1053N|EVC2_ENST00000344408.5_Missense_Mutation_p.D1053N	NM_001166136.1	NP_001159608.1	Q86UK5	LBN_HUMAN	Ellis van Creveld syndrome 2	1053						integral to membrane				NS(2)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(32)|lung(28)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	81						CCGGGCCCATCGGCCACCCAC	0.627000													6	92					0	0	1	0	0
ANKRD24	170961	broad.mit.edu	37	19	4207307	4207307	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr19:4207307C>T	ENST00000600132.1	+	8	811	c.535C>T	c.(535-537)Cgg>Tgg	p.R179W	ANKRD24_ENST00000318934.4_Missense_Mutation_p.R179W|ANKRD24_ENST00000262970.5_Missense_Mutation_p.R269W	NM_133475.1	NP_597732.1	Q8TF21	ANR24_HUMAN	ankyrin repeat domain 24	179										endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	21				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		CCCCCAAGATCGGGTAAGCTT	0.512000											OREG0025162	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	62					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	93027008	93027008	+	Silent	SNP	G	G	A	rs144377527	byFrequency	TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr8:93027008G>A	ENST00000523629.1	-	4	721	c.267C>T	c.(265-267)ggC>ggT	p.G89G	RUNX1T1_ENST00000436581.2_Silent_p.G100G|RUNX1T1_ENST00000520724.1_Silent_p.G52G|RUNX1T1_ENST00000265814.3_Silent_p.G89G|RUNX1T1_ENST00000518844.1_Silent_p.G62G|RUNX1T1_ENST00000422361.2_Silent_p.G52G|RUNX1T1_ENST00000360348.2_Silent_p.G52G|RUNX1T1_ENST00000396218.1_Silent_p.G62G|RUNX1T1_ENST00000521553.1_Silent_p.G52G	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	89					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			GTGAGGGGGCGCCATTCAAGG	0.517000													10	64					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228884221	228884221	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr2:228884221A>T	ENST00000392056.3	-	7	1395	c.1349T>A	c.(1348-1350)aTc>aAc	p.I450N	SPHKAP_ENST00000344657.5_Missense_Mutation_p.I450N	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	450						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		AACAACGACGATTTTGGGGAG	0.502000													18	116					0	0	1	0	0
KANK4	163782	broad.mit.edu	37	1	62740007	62740007	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr1:62740007C>A	ENST00000371153.4	-	3	1147	c.769G>T	c.(769-771)Gtg>Ttg	p.V257L	KANK4_ENST00000354381.3_Intron	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	257	Pro-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						ACTACAAGCACATTCTGGAAT	0.567000													7	68					0.000157383	0.00016949	1	1	0
IYD	389434	broad.mit.edu	37	6	150719234	150719234	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr6:150719234G>T	ENST00000344419.3	+	5	871	c.731G>T	c.(730-732)gGc>gTc	p.G244V	IYD_ENST00000392256.2_3'UTR|IYD_ENST00000229447.5_Missense_Mutation_p.W281C	NM_203395.2	NP_981932.1	Q6PHW0	IYD1_HUMAN	iodotyrosine deiodinase	244					cellular nitrogen compound metabolic process|hormone biosynthetic process	integral to membrane|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	15		Ovarian(120;0.028)	BRCA - Breast invasive adenocarcinoma(37;0.215)	OV - Ovarian serous cystadenocarcinoma(155;4.16e-12)		CTCAACTGTGGCCCTCGACTG	0.567000													13	121					2.23348e-06	2.52677e-06	1	1	0
CREB5	9586	broad.mit.edu	37	7	28858838	28858838	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr7:28858838G>A	ENST00000357727.2	+	11	1859	c.1469G>A	c.(1468-1470)gGa>gAa	p.G490E	CREB5_ENST00000409603.1_Missense_Mutation_p.G457E|CREB5_ENST00000396300.2_Missense_Mutation_p.G483E|CREB5_ENST00000396299.2_Missense_Mutation_p.G457E|CREB5_ENST00000396298.2_Missense_Mutation_p.G351E	NM_182898.2	NP_878901.2	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	490					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(13)|prostate(1)|skin(3)	32						GAGGTGGTAGGAAGCTCCACC	0.527000													43	219					0	0	1	0	0
VARS2	57176	broad.mit.edu	37	6	30892288	30892288	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr6:30892288C>T	ENST00000321897.5	+	25	3256	c.2624C>T	c.(2623-2625)cCc>cTc	p.P875L	VARS2_ENST00000542001.1_Missense_Mutation_p.P735L|VARS2_ENST00000476162.1_3'UTR|VARS2_ENST00000541562.1_Missense_Mutation_p.P905L|VARS2_ENST00000416670.2_Missense_Mutation_p.P875L			Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	875					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(3)|prostate(3)|skin(4)|urinary_tract(1)	46						CCTGGTTGCCCCCCTGCCCCC	0.682000													4	61					0	0	1	0	0
MC3R	4159	broad.mit.edu	37	20	54824542	54824542	+	Silent	SNP	C	C	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr20:54824542C>A	ENST00000243911.2	+	1	755	c.643C>A	c.(643-645)Cgg>Agg	p.R215R		NM_019888.3	NP_063941.3	P41968	MC3R_HUMAN	melanocortin 3 receptor	252					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(3)|skin(1)	26			Colorectal(105;0.202)			CCTCTTTGCGCGGCTGCACGT	0.572000													12	146					2.80697e-09	3.24104e-09	1	1	0
NOL6	65083	broad.mit.edu	37	9	33469616	33469616	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr9:33469616C>T	ENST00000379471.2	-	5	695	c.608G>A	c.(607-609)cGt>cAt	p.R203H	NOL6_ENST00000464829.1_5'UTR|NOL6_ENST00000455041.2_Missense_Mutation_p.R143H			Q9H6R4	NOL6_HUMAN	nucleolar protein 6 (RNA-associated)	203					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			endometrium(4)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|skin(2)	27			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		GTAGAGGGCACGCTTGCGGAA	0.592000													17	208					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33364161	33364161	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr20:33364161C>A	ENST00000374796.2	-	5	2896	c.326G>T	c.(325-327)cGg>cTg	p.R109L	NCOA6_ENST00000359003.2_Missense_Mutation_p.R109L			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	109	CREBBP-binding region.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						AGCAAGGATCCGTAGCCGCTC	0.522000													19	114					5.03518e-11	5.87438e-11	1	1	0
KLK14	43847	broad.mit.edu	37	19	51581407	51581407	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr19:51581407C>A	ENST00000391802.1	-	7	879	c.661G>T	c.(661-663)Ggg>Tgg	p.G221W	KLK14_ENST00000156499.2_Missense_Mutation_p.G221W	NM_022046.4	NP_071329.2	Q9P0G3	KLK14_HUMAN	kallikrein-related peptidase 14	221	Peptidase S1.				epidermis morphogenesis|fertilization|negative regulation of G-protein coupled receptor protein signaling pathway|positive regulation of G-protein coupled receptor protein signaling pathway|proteolysis|seminal clot liquefaction	extracellular space	serine-type endopeptidase activity			kidney(4)|large_intestine(1)|lung(4)|skin(1)|urinary_tract(1)	11		all_neural(266;0.0199)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00422)		AGGGGTCCCCCAGAGTCACCC	0.622000													13	65					9.31168e-06	1.04291e-05	1	1	0
LAMA1	284217	broad.mit.edu	37	18	7013898	7013898	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr18:7013898G>T	ENST00000389658.3	-	23	3372	c.3279C>A	c.(3277-3279)gaC>gaA	p.D1093E		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	1093	Laminin EGF-like 13.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCCCCCTCAGGTCACAGTCAC	0.597000													6	34					0.00116845	0.00122305	1	1	0
CAND1	55832	broad.mit.edu	37	12	67691275	67691275	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr12:67691275A>G	ENST00000545606.1	+	5	1017	c.580A>G	c.(580-582)Aga>Gga	p.R194G		NM_018448.3	NP_060918.2	Q86VP6	CAND1_HUMAN	cullin-associated and neddylation-dissociated 1	194					cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)	35			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		AGTGAGGAAAAGAACCATTAT	0.393000													12	93					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76433876	76433876	+	Silent	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr17:76433876C>T	ENST00000389840.5	-	74	11986	c.11862G>A	c.(11860-11862)gaG>gaA	p.E3954E	DNAH17_ENST00000585328.1_Silent_p.E3955E|DNAH17_ENST00000586052.1_5'UTR					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CCCGGTAGTCCTCATGGCTGC	0.607000													20	102					0	0	1	0	0
SEMA6D	80031	broad.mit.edu	37	15	48056082	48056082	+	Silent	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr15:48056082C>T	ENST00000316364.5	+	10	1222	c.783C>T	c.(781-783)aaC>aaT	p.N261N	SEMA6D_ENST00000558816.1_Silent_p.N261N|SEMA6D_ENST00000358066.4_Silent_p.N261N|SEMA6D_ENST00000389432.2_Silent_p.N261N|SEMA6D_ENST00000537942.1_Silent_p.N261N|SEMA6D_ENST00000389425.3_Silent_p.N261N|SEMA6D_ENST00000389428.3_Silent_p.N261N|SEMA6D_ENST00000536845.2_Silent_p.N261N|SEMA6D_ENST00000558014.1_Silent_p.N261N|SEMA6D_ENST00000355997.3_Silent_p.N261N|SEMA6D_ENST00000389433.2_Silent_p.N261N|SEMA6D_ENST00000354744.4_Silent_p.N261N	NM_153618.1	NP_705871.1	Q8NFY4	SEM6D_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	261	Sema.				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			biliary_tract(1)|breast(4)|endometrium(4)|kidney(5)|large_intestine(10)|lung(42)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	77		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		TATGTAAAAACGACATGGGTG	0.483000													7	209					0	0	1	0	0
FAM65C	140876	broad.mit.edu	37	20	49218695	49218695	+	Silent	SNP	G	G	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr20:49218695G>A	ENST00000327979.2	-	13	1972	c.1561C>T	c.(1561-1563)Ctg>Ttg	p.L521L	FAM65C_ENST00000045083.2_Silent_p.L521L|FAM65C_ENST00000535356.1_Silent_p.L525L			Q96MK2	FA65C_HUMAN	family with sequence similarity 65, member C	521										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(1)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AGCAACTCCAGGACCTCCTGC	0.701000													7	61					0	0	1	0	0
HLF	3131	broad.mit.edu	37	17	53345371	53345371	+	Silent	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr17:53345371C>T	ENST00000226067.5	+	2	848	c.375C>T	c.(373-375)gaC>gaT	p.D125D	HLF_ENST00000575345.1_Silent_p.D40D|HLF_ENST00000430986.2_Silent_p.D40D|HLF_ENST00000573945.1_Silent_p.D40D	NM_002126.4	NP_002117.1	Q16534	HLF_HUMAN	hepatic leukemia factor	125					multicellular organismal development|rhythmic process|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(2)	3						CGGTCATGGACCTCAGCAGCC	0.617000			T	TCF3	ALL								75	243					0	0	1	0	0
APOL2	23780	broad.mit.edu	37	22	36623688	36623688	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr22:36623688C>G	ENST00000249066.6	-	6	1252	c.776G>C	c.(775-777)aGg>aCg	p.R259T	APOL2_ENST00000451256.2_Missense_Mutation_p.R371T|APOL2_ENST00000358502.5_Missense_Mutation_p.R259T	NM_145637.1	NP_663612.1	Q9BQE5	APOL2_HUMAN	apolipoprotein L, 2	259					acute-phase response|cholesterol metabolic process|lipid transport|lipoprotein metabolic process|maternal process involved in female pregnancy|multicellular organismal development	endoplasmic reticulum membrane|extracellular region	high-density lipoprotein particle binding|lipid binding|receptor binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)|skin(1)|urinary_tract(2)	9						TTCAACAACCCTCTCAACCTG	0.587000													20	206					0	0	1	0	0
CD177	57126	broad.mit.edu	37	19	43865691	43865691	+	RNA	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr19:43865691C>T	ENST00000378009.4	+	0	1202				CTC-490G23.4_ENST00000607109.1_RNA|CD177_ENST00000607517.1_RNA	NM_020406.2	NP_065139.2	Q8N6Q3	CD177_HUMAN	CD177 molecule						blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Prostate(69;0.00682)				GCCCCAGGGGCGCCACTCATT	0.617000													3	36					0	0	1	0	0
ZNF28	7576	broad.mit.edu	37	19	53311280	53311280	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr19:53311280T>C	ENST00000457749.2	-	3	241	c.122A>G	c.(121-123)tAt>tGt	p.Y41C	ZNF28_ENST00000339844.6_Missense_Mutation_p.Y5C|ZNF28_ENST00000594602.1_Missense_Mutation_p.Y41C|ZNF28_ENST00000414252.2_Intron|ZNF28_ENST00000360272.4_5'UTR|ZNF28_ENST00000464469.2_5'UTR	NM_006969.3	NP_008900.3	P17035	ZNF28_HUMAN	zinc finger protein 28	41	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|liver(1)|lung(10)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		CAGGTTCCTATAATTCTCCAG	0.498000													35	149					0	0	1	0	0
VPS13A	23230	broad.mit.edu	37	9	79985363	79985363	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr9:79985363G>T	ENST00000360280.3	+	65	9036	c.8776G>T	c.(8776-8778)Ggt>Tgt	p.G2926C	VPS13A_ENST00000376636.3_Missense_Mutation_p.G2887C|VPS13A_ENST00000376634.4_Missense_Mutation_p.G2926C|VPS13A_ENST00000357409.5_Missense_Mutation_p.G2926C	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)	2926					Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						CAAAATCACCGGTGCTATGGC	0.428000													3	72					0.115264	0.116302	1	1	0
TSHZ3	57616	broad.mit.edu	37	19	31768019	31768019	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr19:31768019G>A	ENST00000240587.4	-	2	3007	c.2680C>T	c.(2680-2682)Cgc>Tgc	p.R894C		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	894					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					TTTGACTGGCGGCCCTTCCTC	0.602000													8	106					0	0	1	0	0
LOC728323	728323	broad.mit.edu	37	2	243037115	243037115	+	RNA	SNP	A	A	G			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr2:243037115A>G	ENST00000456398.1	+	0	247																											GGCTGGAAGAATTGTGAATCT	0.398000													3	66					0	0	1	0	0
HMGCS1	3157	broad.mit.edu	37	5	43298662	43298662	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr5:43298662C>T	ENST00000325110.6	-	3	612	c.406G>A	c.(406-408)Gtc>Atc	p.V136I	HMGCS1_ENST00000433297.2_Missense_Mutation_p.V136I	NM_001098272.2	NP_001091742.1	Q01581	HMCS1_HUMAN	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	136					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|soluble fraction	hydroxymethylglutaryl-CoA synthase activity			NS(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|stomach(1)|urinary_tract(1)	15						GCATTGAAGACAGCAGCTGTG	0.433000													15	57					0	0	1	0	0
QPCTL	54814	broad.mit.edu	37	19	46206195	46206195	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr19:46206195T>A	ENST00000012049.5	+	7	1258	c.1037T>A	c.(1036-1038)tTc>tAc	p.F346Y	QPCTL_ENST00000366382.4_Missense_Mutation_p.F252Y	NM_017659.3	NP_060129.2	Q9NXS2	QPCTL_HUMAN	glutaminyl-peptide cyclotransferase-like	346					peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	Golgi membrane|integral to membrane	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|protein binding|zinc ion binding			breast(1)|cervix(2)|endometrium(1)|lung(5)|skin(1)|stomach(1)	11		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0059)|GBM - Glioblastoma multiforme(486;0.0882)|Epithelial(262;0.208)		TCCACGCCCTTCCCTGCTGTC	0.597000													14	244					0	0	1	0	0
CRMP1	1400	broad.mit.edu	37	4	5862777	5862777	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr4:5862777G>C	ENST00000324989.7	-	3	719	c.631C>G	c.(631-633)Ctg>Gtg	p.L211V	CRMP1_ENST00000397890.2_Missense_Mutation_p.L97V|CRMP1_ENST00000512574.1_Missense_Mutation_p.L95V|CRMP1_ENST00000511535.1_5'UTR	NM_001014809.1	NP_001014809.1	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1	97					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			NS(1)|cervix(2)|endometrium(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36				Colorectal(103;0.0721)		CCGCCCACCAGTGCCGCCCTG	0.572000													19	82					0	0	1	0	0
TMEM246	84302	broad.mit.edu	37	9	104238690	104238690	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr9:104238690G>A	ENST00000374851.1	-	4	1832	c.685C>T	c.(685-687)Cgg>Tgg	p.R229W	TMEM246_ENST00000374847.1_Missense_Mutation_p.R229W|RP11-490D19.6_ENST00000424154.1_RNA|RP11-490D19.6_ENST00000425734.1_RNA|RP11-490D19.6_ENST00000450109.1_RNA|TMEM246_ENST00000374848.3_Missense_Mutation_p.R229W|RP11-490D19.6_ENST00000431507.1_RNA			Q9BRR3	CI125_HUMAN	transmembrane protein 246	229						integral to membrane											AAGCGAGCCCGCAGAAGGTGC	0.542000													7	100					0	0	1	0	0
CRMP1	1400	broad.mit.edu	37	4	5862776	5862776	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr4:5862776A>G	ENST00000324989.7	-	3	720	c.632T>C	c.(631-633)cTg>cCg	p.L211P	CRMP1_ENST00000397890.2_Missense_Mutation_p.L97P|CRMP1_ENST00000512574.1_Missense_Mutation_p.L95P|CRMP1_ENST00000511535.1_5'UTR	NM_001014809.1	NP_001014809.1	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1	97					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			NS(1)|cervix(2)|endometrium(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36				Colorectal(103;0.0721)		CCCGCCCACCAGTGCCGCCCT	0.572000													19	80					0	0	1	0	0
ZNF829	374899	broad.mit.edu	37	19	37383112	37383112	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr19:37383112C>A	ENST00000520965.1	-	6	890	c.824G>T	c.(823-825)aGt>aTt	p.S275I	ZNF829_ENST00000391711.3_Missense_Mutation_p.S194I|ZNF345_ENST00000526123.1_Intron|ZNF345_ENST00000432005.2_Intron	NM_001171979.1	NP_001165450.1	Q3KNS6	ZN829_HUMAN	zinc finger protein 829	194					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(11)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	29	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGAGCCACGACTAAAGGACTT	0.368000													4	40					0.150653	0.150653	1	1	0
HKDC1	80201	broad.mit.edu	37	10	71008250	71008250	+	Missense_Mutation	SNP	G	G	A	rs61756700		TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr10:71008250G>A	ENST00000354624.5	+	10	1469	c.1336G>A	c.(1336-1338)Gag>Aag	p.E446K	HKDC1_ENST00000395086.2_Missense_Mutation_p.E446K|HKDC1_ENST00000488706.1_3'UTR	NM_025130.3	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	446					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						CCTCCTGTCAGAGAGTGGCAG	0.602000													9	132					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73270923	73270923	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr10:73270923A>G	ENST00000224721.6	+	5	388	c.383A>G	c.(382-384)aAc>aGc	p.N128S	CDH23_ENST00000398809.4_Missense_Mutation_p.N128S|CDH23_ENST00000299366.7_Missense_Mutation_p.N173S|CDH23_ENST00000398842.3_Missense_Mutation_p.N128S|CDH23_ENST00000461841.3_Missense_Mutation_p.N173S|CDH23-AS1_ENST00000428918.1_RNA	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	128	Cadherin 1.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						GTGAATGACAACGCGCCCACA	0.577000													30	190					0	0	1	0	0
ZNF334	55713	broad.mit.edu	37	20	45131187	45131187	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr20:45131187G>A	ENST00000457685.2	-	6	2000	c.677C>T	c.(676-678)cCg>cTg	p.P226L	ZNF334_ENST00000347606.4_Missense_Mutation_p.P264L|ZNF334_ENST00000593880.1_Missense_Mutation_p.P287L			Q9HCZ1	ZN334_HUMAN	zinc finger protein 334	264					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)				ACAAACATACGGTTTCTCCCC	0.398000													5	100					0	0	1	0	0
TECRL	253017	broad.mit.edu	37	4	65188433	65188433	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr4:65188433G>T	ENST00000381210.3	-	4	519	c.409C>A	c.(409-411)Cta>Ata	p.L137I	TECRL_ENST00000507440.1_Missense_Mutation_p.L137I	NM_001010874.4	NP_001010874.2	Q5HYJ1	TECRL_HUMAN	trans-2,3-enoyl-CoA reductase-like	137					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors			endometrium(2)|kidney(5)|large_intestine(7)|lung(30)|prostate(1)|skin(1)|stomach(1)	47						TGTTGACCTAGGTCTGTAGCA	0.323000													5	38					8.12818e-05	8.83841e-05	1	1	0
RPL22L1	200916	broad.mit.edu	37	3	170587949	170587949	+	Splice_Site	SNP	G	G	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr3:170587949G>A	ENST00000295830.8	-	1	323	c.8C>T	c.(7-9)cCg>cTg	p.P3L	RPL22L1_ENST00000463836.1_Splice_Site_p.P3L	NM_001099645.1	NP_001093115.1	Q6P5R6	RL22L_HUMAN	ribosomal protein L22-like 1	3					translation	ribosome	structural constituent of ribosome			kidney(2)|large_intestine(1)|upper_aerodigestive_tract(1)	4	all_cancers(22;1.96e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.137)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			CTCACTCACCGGCGCCATCTT	0.552000													12	71					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204943867	204943867	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr1:204943867C>T	ENST00000367172.4	+	14	1802	c.1474C>T	c.(1474-1476)Cgc>Tgc	p.R492C	NFASC_ENST00000338515.6_Missense_Mutation_p.R492C|NFASC_ENST00000367169.4_Missense_Mutation_p.R492C|NFASC_ENST00000513543.1_Missense_Mutation_p.R503C|NFASC_ENST00000338586.6_Missense_Mutation_p.R492C|NFASC_ENST00000360049.4_Missense_Mutation_p.R503C|NFASC_ENST00000403080.1_Missense_Mutation_p.R492C|NFASC_ENST00000401399.1_Missense_Mutation_p.R492C|NFASC_ENST00000404076.1_Missense_Mutation_p.R486C|NFASC_ENST00000339876.6_Missense_Mutation_p.R492C|NFASC_ENST00000539706.1_Missense_Mutation_p.R503C|NFASC_ENST00000367171.4_Missense_Mutation_p.R492C|NFASC_ENST00000367170.4_Missense_Mutation_p.R492C|NFASC_ENST00000404907.1_Missense_Mutation_p.R503C			O94856	NFASC_HUMAN	neurofascin	492	Ig-like C2-type 5.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding	p.R492S(2)|p.R503C(1)|p.R503S(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			TAAGATGATCCGCAAAGAGGA	0.507000													12	186					0	0	1	0	0
TRPV6	55503	broad.mit.edu	37	7	142574898	142574898	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr7:142574898A>G	ENST00000359396.3	-	4	729	c.484T>C	c.(484-486)Ttt>Ctt	p.F162L	RP11-114L10.2_ENST00000438839.1_RNA	NM_018646.3	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel, subfamily V, member 6	162					regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	42	Melanoma(164;0.059)					ctctCACCAAAGTAGATGAGG	0.627000													15	65					0	0	1	0	0
LEFTY2	7044	broad.mit.edu	37	1	226125381	226125381	+	Silent	SNP	G	G	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr1:226125381G>T	ENST00000366820.5	-	4	1209	c.861C>A	c.(859-861)ggC>ggA	p.G287G	LEFTY2_ENST00000420304.2_Silent_p.G253G	NM_003240.3	NP_003231.2	O00292	LFTY2_HUMAN	left-right determination factor 2	287					cell growth|multicellular organismal development|platelet activation|platelet degranulation|transforming growth factor beta receptor signaling pathway	extracellular space|platelet alpha granule lumen	cytokine activity|growth factor activity|transforming growth factor beta receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	16	Breast(184;0.197)					AAGCCAGGAAGCCCGGGGGCT	0.642000													6	59					5.9392e-07	6.78766e-07	1	1	0
LOC101927209	101927209	broad.mit.edu	37	1	142713774	142713774	+	RNA	SNP	A	A	G			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr1:142713774A>G	ENST00000610091.1	-	0	1884																											CTTTTTCCACATTGTCATTTT	0.284000													5	34					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34100917	34100917	+	Silent	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr6:34100917C>T	ENST00000538487.2	-	2	800	c.357G>A	c.(355-357)tcG>tcA	p.S119S	GRM4_ENST00000374177.3_Intron|GRM4_ENST00000374181.4_Silent_p.S119S	NM_000841.2|NM_001256811.1	NP_000832.1|NP_001243740.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4						activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	CAAAGGTCAGCGACTGCTCGA	0.627000													4	39					0	0	1	0	0
PMM2	5373	broad.mit.edu	37	16	8891772	8891772	+	Silent	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr16:8891772C>T	ENST00000268261.4	+	1	99	c.33C>T	c.(31-33)ttC>ttT	p.F11F	PMM2_ENST00000566983.1_Intron|PMM2_ENST00000539622.1_5'UTR|PMM2_ENST00000569958.1_Silent_p.F11F|PMM2_ENST00000537352.1_5'UTR	NM_000303.2	NP_000294.1	O15305	PMM2_HUMAN	phosphomannomutase 2	11			F -> C (in CDG1A).		dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	phosphomannomutase activity			breast(3)|cervix(1)|endometrium(2)|large_intestine(1)|ovary(1)|skin(1)	9						TCTGCCTCTTCGACGTGGATG	0.682000													4	35					0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58141789	58141789	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr3:58141789T>G	ENST00000295956.4	+	41	7040	c.6875T>G	c.(6874-6876)gTt>gGt	p.V2292G	FLNB_ENST00000358537.3_Missense_Mutation_p.V2268G|FLNB_ENST00000357272.4_3'UTR|FLNB_ENST00000429972.2_Missense_Mutation_p.V2281G|FLNB_ENST00000419752.2_Missense_Mutation_p.V2112G|FLNB_ENST00000348383.5_Missense_Mutation_p.V2251G|FLNB_ENST00000490882.1_Missense_Mutation_p.V2323G|FLNB_ENST00000493452.1_Missense_Mutation_p.V2099G	NM_001457.3	NP_001448.2	O75369	FLNB_HUMAN	filamin B, beta	2292	Interaction with INPPL1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CGCCTCACTGTTATGAGCCTT	0.587000													12	70					0	0	1	0	0
ADCY5	111	broad.mit.edu	37	3	123066746	123066746	+	Missense_Mutation	SNP	C	C	G	rs139672003		TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr3:123066746C>G	ENST00000462833.1	-	3	2501	c.1289G>C	c.(1288-1290)cGg>cCg	p.R430P	ADCY5_ENST00000491190.1_Missense_Mutation_p.R63P|ADCY5_ENST00000309879.5_Missense_Mutation_p.R80P	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	430					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		CAGCAGGAGCCGTTCCTGCAG	0.557000													29	294					0	0	1	0	0
FBXO41	150726	broad.mit.edu	37	2	73493785	73493785	+	Silent	SNP	G	G	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr2:73493785G>A	ENST00000521871.1	-	3	1346	c.931C>T	c.(931-933)Ctg>Ttg	p.L311L	FBXO41_ENST00000295133.5_Silent_p.L372L|FBXO41_ENST00000520530.2_Silent_p.L311L			Q8TF61	FBX41_HUMAN	F-box protein 41	311						intracellular	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|lung(6)|pancreas(1)|prostate(1)|skin(1)	13						GTCTCCTTCAGGAACTGGTCG	0.677000													18	92					0	0	1	0	0
S1PR5	53637	broad.mit.edu	37	19	10624575	10624575	+	Silent	SNP	G	G	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr19:10624575G>A	ENST00000439028.3	-	2	1238	c.1113C>T	c.(1111-1113)gaC>gaT	p.D371D	S1PR5_ENST00000333430.4_Silent_p.D371D	NM_001166215.1	NP_001159687.1	Q9H228	S1PR5_HUMAN	sphingosine-1-phosphate receptor 5	371						integral to membrane|plasma membrane	lysosphingolipid and lysophosphatidic acid receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	12						TGTCCAGCCCGTCGCGCTGGG	0.736000													10	64					0	0	1	0	0
KDM3A	55818	broad.mit.edu	37	2	86701912	86701912	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr2:86701912A>G	ENST00000409556.1	+	13	2103	c.1738A>G	c.(1738-1740)Aaa>Gaa	p.K580E	KDM3A_ENST00000542128.1_Missense_Mutation_p.K528E|KDM3A_ENST00000485171.1_3'UTR|KDM3A_ENST00000409064.1_Missense_Mutation_p.K580E|KDM3A_ENST00000312912.5_Missense_Mutation_p.K580E			Q9Y4C1	KDM3A_HUMAN	lysine (K)-specific demethylase 3A	580					androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(3)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|liver(1)|lung(13)|ovary(1)|prostate(3)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	47						ACAATTCAACAAACATGGTGT	0.413000													12	91					0	0	1	0	0
DLG1	1739	broad.mit.edu	37	3	197024064	197024064	+	Silent	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr3:197024064C>T	ENST00000346964.2	-	2	201	c.12G>A	c.(10-12)cgG>cgA	p.R4R	DLG1_ENST00000392382.2_Silent_p.R4R|DLG1_ENST00000448528.2_Silent_p.R4R|DLG1_ENST00000450955.1_Silent_p.R4R|DLG1_ENST00000357674.4_Silent_p.R4R|DLG1_ENST00000419354.1_Silent_p.R4R|DLG1_ENST00000422288.1_Silent_p.R4R|DLG1_ENST00000314062.3_Silent_p.R4R	NM_004087.2	NP_004078.2	Q12959	DLG1_HUMAN	discs, large homolog 1 (Drosophila)	4	L27.				actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|liver(1)|lung(9)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	26	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		CACCTTGCTTCCGGACCGGCA	0.408000													6	28					0	0	1	0	0
CAPN7	23473	broad.mit.edu	37	3	15262300	15262300	+	Silent	SNP	G	G	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr3:15262300G>A	ENST00000253693.2	+	5	703	c.450G>A	c.(448-450)ctG>ctA	p.L150L		NM_014296.2	NP_055111.1	Q9Y6W3	CAN7_HUMAN	calpain 7	150					proteolysis	nucleus	calcium-dependent cysteine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|skin(2)	22						CAGAAGCGCTGAGTGAGCCTT	0.428000													10	56					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10473957	10473957	+	Splice_Site	SNP	G	G	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr8:10473957G>A	ENST00000382483.3	-	3	973	c.750C>T	c.(748-750)aaC>aaT	p.N250N		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	250					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CCAACTCACCGTTTTTGTTTC	0.498000													20	109					0	0	1	0	0
XRN2	22803	broad.mit.edu	37	20	21335466	21335466	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr20:21335466G>A	ENST00000377191.3	+	21	2071	c.1976G>A	c.(1975-1977)cGa>cAa	p.R659Q	XRN2_ENST00000539513.1_Missense_Mutation_p.R605Q|XRN2_ENST00000430571.2_Missense_Mutation_p.R583Q	NM_012255.3	NP_036387.2	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	659					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			endometrium(5)|kidney(6)|large_intestine(10)|lung(12)|ovary(1)|skin(5)	39						CGAAGGCTACGAGCTGCCCTA	0.418000													7	29					0	0	1	0	0
PTPRS	5802	broad.mit.edu	37	19	5215324	5215324	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr19:5215324G>A	ENST00000372412.4	-	28	4530	c.4297C>T	c.(4297-4299)Cgt>Tgt	p.R1433C	PTPRS_ENST00000588012.1_Missense_Mutation_p.R1394C|PTPRS_ENST00000587303.1_Missense_Mutation_p.R1432C|PTPRS_ENST00000592099.1_Missense_Mutation_p.R985C|PTPRS_ENST00000348075.2_Missense_Mutation_p.R1394C|PTPRS_ENST00000353284.2_Missense_Mutation_p.R985C|PTPRS_ENST00000357368.4_Missense_Mutation_p.R1432C|PTPRS_ENST00000588552.1_5'UTR|PTPRS_ENST00000262963.6_Missense_Mutation_p.R1412C			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	1432	Tyrosine-protein phosphatase 1.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		AGGATGACACGGGAGTGGTCA	0.552000													32	111					0	0	1	0	0
APOBEC3A	200315	broad.mit.edu	37	22	39355616	39355616	+	Silent	SNP	G	G	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr22:39355616G>A	ENST00000402255.1	+	3	303	c.99G>A	c.(97-99)ctG>ctA	p.L33L	APOBEC3A_ENST00000249116.2_Silent_p.L33L					apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A											large_intestine(1)|lung(2)|ovary(1)|skin(1)	5	Melanoma(58;0.04)					AGACCTACCTGTGCTACGAAG	0.527000													7	114					0	0	1	0	0
STAU2	27067	broad.mit.edu	37	8	74495042	74495042	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr8:74495042A>T	ENST00000355780.5	-	11	1307	c.1089T>A	c.(1087-1089)agT>agA	p.S363R	STAU2_ENST00000524300.1_Missense_Mutation_p.S395R|STAU2_ENST00000521210.1_Missense_Mutation_p.S291R|STAU2_ENST00000523558.1_Missense_Mutation_p.S223R|STAU2_ENST00000517542.1_Missense_Mutation_p.S357R|STAU2_ENST00000522695.1_Missense_Mutation_p.S363R|STAU2_ENST00000521451.1_Missense_Mutation_p.S175R|STAU2_ENST00000519961.1_Missense_Mutation_p.S395R|STAU2_ENST00000522509.1_Missense_Mutation_p.S363R|STAU2_ENST00000521727.1_Missense_Mutation_p.S375R	NM_014393.2	NP_055208.2	Q9NUL3	STAU2_HUMAN	staufen double-stranded RNA binding protein 2	395	DRBM 4.				transport	endoplasmic reticulum|microtubule|nucleolus	double-stranded RNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)	19	Breast(64;0.0138)		Epithelial(68;0.026)|BRCA - Breast invasive adenocarcinoma(89;0.0483)|all cancers(69;0.0972)			GCTTTGGACCACTCCATCCTT	0.373000													12	99					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	185878634	185878634	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr1:185878634C>G	ENST00000271588.4	+	5	1016	c.787C>G	c.(787-789)Cct>Gct	p.P263A	HMCN1_ENST00000367492.2_Missense_Mutation_p.P263A	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	263					response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						AATTCGCAATCCTTTAGGTGA	0.363000													5	27					0	0	1	0	0
CROCCP2	84809	broad.mit.edu	37	1	16946407	16946407	+	RNA	SNP	T	T	G	rs10796418	by1000genomes	TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr1:16946407T>G	ENST00000412962.1	-	0	1112																											AGCAATCTCCTCACTCAGCTG	0.672000													3	38					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41554073	41554073	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr8:41554073C>T	ENST00000396942.1	-	26	2851	c.2768G>A	c.(2767-2769)gGt>gAt	p.G923D	ANK1_ENST00000379758.2_Missense_Mutation_p.G923D|ANK1_ENST00000289734.7_Missense_Mutation_p.G923D|ANK1_ENST00000396945.1_Missense_Mutation_p.G923D|ANK1_ENST00000352337.4_Missense_Mutation_p.G923D|ANK1_ENST00000347528.4_Missense_Mutation_p.G923D|ANK1_ENST00000265709.8_Missense_Mutation_p.G964D			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	923	ZU5.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CATGGAACCACCCCGGGCGTC	0.647000													14	81					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22383399	22383399	+	Silent	SNP	A	A	G			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr15:22383399A>G	ENST00000328795.4	+	1	1018	c.927A>G	c.(925-927)caA>caG	p.Q309Q	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	309					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TAGTCTGTCAAGTGGATTTTA	0.383000													8	92					0	0	1	0	0
IL20RA	53832	broad.mit.edu	37	6	137323449	137323449	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr6:137323449G>C	ENST00000367748.1	-	6	1161	c.575C>G	c.(574-576)cCt>cGt	p.P192R	IL20RA_ENST00000541547.1_Missense_Mutation_p.P254R|IL20RA_ENST00000316649.5_Missense_Mutation_p.P303R	NM_001278723.1	NP_001265652.1	Q9UHF4	I20RA_HUMAN	interleukin 20 receptor, alpha	303	Fibronectin type-III 2.					integral to membrane	receptor activity			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	27	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000351)|OV - Ovarian serous cystadenocarcinoma(155;0.00459)		TTTTTCAGCAGGCACAAAGAA	0.308000													5	29					0	0	1	0	0
HNRNPH3	3189	broad.mit.edu	37	10	70100979	70100979	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr10:70100979G>A	ENST00000265866.7	+	7	853	c.688G>A	c.(688-690)Gat>Aat	p.D230N	HNRNPH3_ENST00000354695.5_Missense_Mutation_p.D215N|HNRNPH3_ENST00000441000.2_Missense_Mutation_p.D122N|HNRNPH3_ENST00000469172.1_3'UTR	NM_012207.2|NM_021644.3	NP_036339.1|NP_067676.2	P31942	HNRH3_HUMAN	heterogeneous nuclear ribonucleoprotein H3 (2H9)	230	Gly-rich.|RRM 2.				nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex	nucleotide binding|protein binding|RNA binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(5)|ovary(2)|prostate(2)	11						TATTGGAGCTGATGGCAGAGC	0.353000													6	70					0	0	1	0	0
GRIN1	2902	broad.mit.edu	37	9	140058396	140058396	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr9:140058396C>T	ENST00000350902.5	+	18	2706	c.2629C>T	c.(2629-2631)Cgg>Tgg	p.R877W	GRIN1_ENST00000371553.3_Intron|GRIN1_ENST00000371561.3_Intron|GRIN1_ENST00000371559.4_Intron|GRIN1_ENST00000371560.3_Intron|GRIN1_ENST00000371546.4_Intron|GRIN1_ENST00000371550.4_Intron|GRIN1_ENST00000471122.1_3'UTR|GRIN1_ENST00000315048.3_Intron|GRIN1_ENST00000371555.4_Intron			Q05586	NMDZ1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 1	0					ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	GCCCAGGGCCCGGCCTGGCCA	0.697000													19	49					0	0	1	0	0
CDH17	1015	broad.mit.edu	37	8	95201429	95201429	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr8:95201429G>T	ENST00000027335.3	-	3	260	c.136C>A	c.(136-138)Caa>Aaa	p.Q46K	CDH17_ENST00000441892.2_Missense_Mutation_p.Q46K|CDH17_ENST00000450165.2_Missense_Mutation_p.Q46K	NM_004063.3	NP_004054.3	Q12864	CAD17_HUMAN	cadherin 17, LI cadherin (liver-intestine)	46	Cadherin 1.					integral to membrane	calcium ion binding			NS(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(4)|stomach(2)	52	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			AATATAATTTGACTCGGTTCT	0.398000													6	40					0.00116845	0.00122305	1	1	0
FBXO41	150726	broad.mit.edu	37	2	73493786	73493786	+	Silent	SNP	G	G	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr2:73493786G>A	ENST00000521871.1	-	3	1345	c.930C>T	c.(928-930)ttC>ttT	p.F310F	FBXO41_ENST00000295133.5_Silent_p.F371F|FBXO41_ENST00000520530.2_Silent_p.F310F			Q8TF61	FBX41_HUMAN	F-box protein 41	310						intracellular	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|lung(6)|pancreas(1)|prostate(1)|skin(1)	13						TCTCCTTCAGGAACTGGTCGA	0.682000													18	93					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21939680	21939680	+	Silent	SNP	G	G	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr7:21939680G>A	ENST00000328843.6	+	82	13297	c.13266G>A	c.(13264-13266)aaG>aaA	p.K4422K	DNAH11_ENST00000409508.3_Silent_p.K4415K			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	4422					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						AAAAAACAAAGGAAGATTATG	0.468000									Kartagener syndrome				3	41					0	0	1	0	0
KGFLP2	654466	broad.mit.edu	37	9	41962602	41962602	+	RNA	SNP	G	G	C			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr9:41962602G>C	ENST00000454645.1	-	0	902					NR_003670.1																						TTCTTTCTTTGTTTTTTTTCC	0.373000													4	37					0	0	1	0	0
ISLR2	57611	broad.mit.edu	37	15	74426979	74426979	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr15:74426979C>G	ENST00000361742.3	+	4	2653	c.1884C>G	c.(1882-1884)atC>atG	p.I628M	ISLR2_ENST00000561975.1_Intron|ISLR2_ENST00000565159.1_Missense_Mutation_p.I628M|ISLR2_ENST00000419208.1_Missense_Mutation_p.I628M|ISLR2_ENST00000565540.1_Missense_Mutation_p.I628M|ISLR2_ENST00000445793.1_Missense_Mutation_p.I628M|ISLR2_ENST00000453268.2_Missense_Mutation_p.I628M|ISLR2_ENST00000435464.1_Missense_Mutation_p.I628M	NM_001130136.1|NM_020851.2	NP_001123608.1|NP_065902.1	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing leucine-rich repeat 2	628					positive regulation of axon extension	cell surface|integral to membrane|plasma membrane				breast(3)|endometrium(6)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	36						ACCGTCTGATCCTGCGGCCTC	0.652000											OREG0023277	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	100					0	0	1	0	0
MET	4233	broad.mit.edu	37	7	116398618	116398618	+	Silent	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr7:116398618C>T	ENST00000397752.3	+	9	2408	c.2208C>T	c.(2206-2208)ttC>ttT	p.F736F	MET_ENST00000436117.2_Silent_p.F736F|MET_ENST00000318493.6_Silent_p.F736F	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	736	IPT/TIG 2.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			CAAGCATCTTCAGTTACCGTG	0.358000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				7	44					0	0	1	0	0
DLG1	1739	broad.mit.edu	37	3	197024065	197024065	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr3:197024065C>T	ENST00000346964.2	-	2	200	c.11G>A	c.(10-12)cGg>cAg	p.R4Q	DLG1_ENST00000392382.2_Missense_Mutation_p.R4Q|DLG1_ENST00000448528.2_Missense_Mutation_p.R4Q|DLG1_ENST00000450955.1_Missense_Mutation_p.R4Q|DLG1_ENST00000357674.4_Missense_Mutation_p.R4Q|DLG1_ENST00000419354.1_Missense_Mutation_p.R4Q|DLG1_ENST00000422288.1_Missense_Mutation_p.R4Q|DLG1_ENST00000314062.3_Missense_Mutation_p.R4Q	NM_004087.2	NP_004078.2	Q12959	DLG1_HUMAN	discs, large homolog 1 (Drosophila)	4	L27.				actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|liver(1)|lung(9)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	26	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		ACCTTGCTTCCGGACCGGCAT	0.413000													6	28					0	0	1	0	0
FAM155A	728215	broad.mit.edu	37	13	108518238	108518238	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr13:108518238G>T	ENST00000375915.2	-	1	845	c.707C>A	c.(706-708)tCg>tAg	p.S236*		NM_001080396.2	NP_001073865.1	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	236						integral to membrane	binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						GGACAACCCCGAGAACAACTC	0.537000													38	174					1.08052e-11	1.27388e-11	1	1	0
WNK2	65268	broad.mit.edu	37	9	96021712	96021712	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr9:96021712C>T	ENST00000297954.4	+	11	2882	c.2882C>T	c.(2881-2883)aCg>aTg	p.T961M	WNK2_ENST00000395477.2_Missense_Mutation_p.T961M|WNK2_ENST00000356055.3_5'UTR|WNK2_ENST00000349097.3_Missense_Mutation_p.T573M|WNK2_ENST00000395475.2_3'UTR|WNK2_ENST00000427277.2_Missense_Mutation_p.T573M	NM_001282394.1	NP_001269323.1	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	961					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						CCGCAACCCACGCTGCCCCCT	0.692000													3	12					0	0	1	0	0
KIAA1244	57221	broad.mit.edu	37	6	138576674	138576674	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr6:138576674C>T	ENST00000251691.4	+	10	1038	c.872C>T	c.(871-873)tCg>tTg	p.S291L		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	291					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		AGCCTGGAGTCGGACTCTGCG	0.582000													10	125					0	0	1	0	0
ATP6V1C2	245973	broad.mit.edu	37	2	10908879	10908879	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr2:10908879G>A	ENST00000381661.3	+	6	522	c.413G>A	c.(412-414)cGa>cAa	p.R138Q	RP11-791G15.2_ENST00000606907.1_lincRNA|ATP6V1C2_ENST00000272238.4_Missense_Mutation_p.R138Q	NM_144583.3	NP_653184.2	Q8NEY4	VATC2_HUMAN	ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2	138					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting V-type ATPase, V1 domain				endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.15)|OV - Ovarian serous cystadenocarcinoma(76;0.152)		CTGAAGTCCCGAACGGCCGCC	0.522000													10	119					0	0	1	0	0
APEH	327	broad.mit.edu	37	3	49720139	49720139	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr3:49720139C>T	ENST00000296456.5	+	19	2253	c.1853C>T	c.(1852-1854)tCc>tTc	p.S618F	APEH_ENST00000438011.1_Missense_Mutation_p.S618F	NM_001640.3	NP_001631.3	P13798	ACPH_HUMAN	acylaminoacyl-peptide hydrolase	618					proteolysis	cytoplasm|nuclear membrane	serine-type endopeptidase activity			endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|skin(1)|stomach(2)|urinary_tract(1)	15				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AACATCGCCTCCATGTTGGGC	0.587000													20	140					0	0	1	0	0
ZNF611	81856	broad.mit.edu	37	19	53208600	53208600	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr19:53208600C>T	ENST00000543227.1	-	6	1982	c.1708G>A	c.(1708-1710)Gag>Aag	p.E570K	ZNF611_ENST00000540744.1_Missense_Mutation_p.E570K|ZNF611_ENST00000453741.2_Missense_Mutation_p.E501K|ZNF611_ENST00000602162.1_Missense_Mutation_p.E501K|ZNF611_ENST00000319783.1_Missense_Mutation_p.E570K|ZNF611_ENST00000595798.1_Missense_Mutation_p.E501K	NM_001161499.1	NP_001154971.1	Q8N823	ZN611_HUMAN	zinc finger protein 611	570					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)		TTGCTGCACTCATTACACTTG	0.408000													9	235					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77779435	77779435	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr13:77779435G>A	ENST00000407578.2	-	26	4065	c.3799C>T	c.(3799-3801)Ctt>Ttt	p.L1267F	MYCBP2_ENST00000544440.2_Missense_Mutation_p.L1229F|MYCBP2_ENST00000360084.5_5'UTR|MYCBP2_ENST00000357337.6_Missense_Mutation_p.L1229F	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	1229					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		AACAGACCAAGACCACCAAGT	0.373000													5	42					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71508818	71508818	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr4:71508818C>T	ENST00000396073.3	+	9	1956	c.1675C>T	c.(1675-1677)Cat>Tat	p.H559Y	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	559					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			TGCAAAAGAACATTTTCCTGC	0.433000													16	154					0	0	1	0	0
ZMIZ2	83637	broad.mit.edu	37	7	44802511	44802511	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr7:44802511G>A	ENST00000309315.4	+	12	1751	c.1628G>A	c.(1627-1629)cGc>cAc	p.R543H	ZMIZ2_ENST00000413916.1_Missense_Mutation_p.R485H|ZMIZ2_ENST00000265346.7_Missense_Mutation_p.R517H|ZMIZ2_ENST00000441627.1_Missense_Mutation_p.R543H|ZMIZ2_ENST00000433667.1_Missense_Mutation_p.R511H	NM_031449.3	NP_113637.3	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2	543					positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			breast(3)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						CTAGTGCACCGCCCATCCGTC	0.637000													47	587					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123452617	123452617	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr3:123452617C>T	ENST00000360772.3	-	11	1604	c.1226G>A	c.(1225-1227)aGg>aAg	p.R409K	MYLK_ENST00000360304.3_Missense_Mutation_p.R409K|MYLK_ENST00000359169.1_Missense_Mutation_p.R409K|MYLK_ENST00000346322.5_Missense_Mutation_p.R409K|MYLK_ENST00000475616.1_Missense_Mutation_p.R409K			Q15746	MYLK_HUMAN	myosin light chain kinase	409					aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		TGCTGAATCCCTCTGGCCCTC	0.542000													28	159					0	0	1	0	0
APEH	327	broad.mit.edu	37	3	49720140	49720140	+	Silent	SNP	C	C	T			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr3:49720140C>T	ENST00000296456.5	+	19	2254	c.1854C>T	c.(1852-1854)tcC>tcT	p.S618S	APEH_ENST00000438011.1_Silent_p.S618S	NM_001640.3	NP_001631.3	P13798	ACPH_HUMAN	acylaminoacyl-peptide hydrolase	618					proteolysis	cytoplasm|nuclear membrane	serine-type endopeptidase activity			endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|skin(1)|stomach(2)|urinary_tract(1)	15				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		ACATCGCCTCCATGTTGGGCT	0.587000													20	139					0	0	1	0	0
SLAMF1	6504	broad.mit.edu	37	1	160589601	160589601	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr1:160589601delT	ENST00000302035.6	-	5	1178	c.829delA	c.(829-831)agcfs	p.S277fs	SLAMF1_ENST00000235739.5_Frame_Shift_Del_p.S247fs|SLAMF1_ENST00000355199.3_Frame_Shift_Del_p.S277fs|SLAMF1_ENST00000538290.1_Intron	NM_003037.2	NP_003028.1	Q13291	SLAF1_HUMAN	signaling lymphocytic activation molecule family member 1	277					interspecies interaction between organisms|lymphocyte activation|positive regulation of cell proliferation	integral to membrane	antigen binding|transmembrane receptor activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(52;4.94e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			ATCGTAAGGCTTTTTTTTTCC	0.433													7	167	---	---	---	---					
LRRFIP1	9208	broad.mit.edu	37	2	238668850	238668851	+	Splice_Site	INS	-	-	AG			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr2:238668850_238668851insAG	ENST00000244815.5	+	9	1057		c.e9+2		LRRFIP1_ENST00000308482.9_Splice_Site|LRRFIP1_ENST00000289175.6_Splice_Site|LRRFIP1_ENST00000392000.4_Splice_Site	NM_004735.3	NP_004726.2	Q32MZ4	LRRF1_HUMAN	leucine rich repeat (in FLII) interacting protein 1						negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|cytoskeleton|nucleus	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	29		Breast(86;0.00257)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;9.75e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.01e-10)|Kidney(56;4.85e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.31e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000151)|Lung(119;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0325)|COAD - Colon adenocarcinoma(134;0.228)		GGACCCTAGGTAAGTATTTGCT	0.505													8	34	---	---	---	---					
EMC3-AS1	442075	broad.mit.edu	37	3	10035779	10035783	+	RNA	DEL	AGTCT	AGTCT	-	rs35714562		TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr3:10035779_10035783delAGTCT	ENST00000326237.3	+	0	354																											GGGGAAGAGAAGTCTGATCTGACAT	0.380													7	50	---	---	---	---					
OR2H2	7932	broad.mit.edu	37	6	29556126	29556126	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr6:29556126delC	ENST00000383640.2	+	1	444	c.405delC	c.(403-405)cacfs	p.H135fs	GABBR1_ENST00000355973.3_Intron	NM_007160.3	NP_009091.3	O95918	OR2H2_HUMAN	olfactory receptor, family 2, subfamily H, member 2	135					defense response|mating|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)|urinary_tract(1)	14						CCATCATCCACCCCCGCCTGT	0.612													7	297	---	---	---	---					
LINC00502	100874184	broad.mit.edu	37	10	92813180	92813180	+	RNA	DEL	A	A	-	rs111380766		TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr10:92813180delA	ENST00000423621.1	+	0	264																											TGGGCCTGATAAAAAAAAAGC	0.343													2	4	---	---	---	---					
RXFP2	122042	broad.mit.edu	37	13	32376429	32376429	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr13:32376429delA	ENST00000298386.2	+	18	2223	c.2152delA	c.(2152-2154)aaafs	p.K720fs	RXFP2_ENST00000380314.1_Frame_Shift_Del_p.K696fs	NM_130806.3	NP_570718.1	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	720						integral to membrane|plasma membrane				cervix(1)|endometrium(2)|large_intestine(15)|lung(13)|prostate(1)|stomach(1)	33		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		TTTCAAAATTAAAAAAAAAAG	0.348													8	114	---	---	---	---					
ZFP36L1	677	broad.mit.edu	37	14	69256543	69256544	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr14:69256543_69256544insA	ENST00000439696.2	-	2	1024_1025	c.723_724insT	c.(721-726)cctaccfs	p.T242fs	ZFP36L1_ENST00000555997.1_3'UTR|ZFP36L1_ENST00000336440.3_Frame_Shift_Ins_p.T242fs	NM_001244701.1|NM_004926.3	NP_001231630.1|NP_004917.2	Q07352	TISB_HUMAN	ZFP36 ring finger protein-like 1	242					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.T242A(1)		breast(4)|kidney(1)|large_intestine(1)|liver(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(1)	21				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		TCGGGCAGGGTAGGTGAGCCCA	0.678											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	292	---	---	---	---					
ZFP36L1	677	broad.mit.edu	37	14	69257035	69257036	+	Frame_Shift_Ins	INS	-	-	GG			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr14:69257035_69257036insGG	ENST00000439696.2	-	2	532_533	c.231_232insCC	c.(229-234)cccgctfs	p.A78fs	ZFP36L1_ENST00000555997.1_3'UTR|ZFP36L1_ENST00000336440.3_Frame_Shift_Ins_p.A78fs	NM_001244701.1|NM_004926.3	NP_001231630.1|NP_004917.2	Q07352	TISB_HUMAN	ZFP36 ring finger protein-like 1	78					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.P77fs*67(1)		breast(4)|kidney(1)|large_intestine(1)|liver(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(1)	21				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GAGCTCAGAGCGGGGGCTGGCT	0.688											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	59	---	---	---	---					
HERC2P2	400322	broad.mit.edu	37	15	23312380	23312380	+	RNA	DEL	T	T	-			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr15:23312380delT	ENST00000560464.1	-	0	3118																											TGTTAttttcttttttttttt	0.398													2	4	---	---	---	---					
SLTM	79811	broad.mit.edu	37	15	59182525	59182526	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr15:59182525_59182526delTC	ENST00000380516.2	-	15	2120_2121	c.2033_2034delGA	c.(2032-2034)agafs	p.R678fs	AC025918.2_ENST00000452467.1_RNA|SLTM_ENST00000536328.1_Frame_Shift_Del_p.R247fs	NM_001013843.1|NM_024755.2	NP_001013865.1|NP_079031.2	Q9NWH9	SLTM_HUMAN	SAFB-like, transcription modulator	678	Arg/Glu-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CGCGTTCCATTCTCTCTCTCTC	0.431													7	227	---	---	---	---					
DIS3L	115752	broad.mit.edu	37	15	66587463	66587464	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr15:66587463_66587464insA	ENST00000319194.5	+	2	289_290	c.28_29insA	c.(28-30)catfs	p.H10fs	DIS3L_ENST00000441424.2_5'UTR|DIS3L_ENST00000319212.4_Frame_Shift_Ins_p.H93fs	NM_133375.3	NP_588616.1	Q8TF46	DI3L1_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)-like	93					rRNA catabolic process	cytoplasm|exosome (RNase complex)	exonuclease activity|protein binding|ribonuclease activity|RNA binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						AGCTGTGCAGCATCAAAGAGGC	0.450													8	109	---	---	---	---					
ZNF57	126295	broad.mit.edu	37	19	2917370	2917370	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FD-A43U-01A-11D-A23U-08	TCGA-FD-A43U-10A-01D-A23U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	155a5d7c-111f-4b4e-a53f-e1dc126e452f	eee5f541-146e-422a-9e76-67553e23c6ee	g.chr19:2917370delC	ENST00000306908.5	+	4	899	c.751delC	c.(751-753)ccafs	p.P251fs	AC006277.2_ENST00000520090.2_RNA|ZNF57_ENST00000523428.1_Frame_Shift_Del_p.P219fs	NM_173480.2	NP_775751.1	Q68EA5	ZNF57_HUMAN	zinc finger protein 57	251					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.00161)|STAD - Stomach adenocarcinoma(1328;0.18)		AAAAGACAGGCCATATAAATG	0.448													20	112	---	---	---	---					
