Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
POLR1A	25885	broad.mit.edu	37	2	86258591	86258591	+	Silent	SNP	C	C	G			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr2:86258591C>G	ENST00000263857.6	-	30	4818	c.4440G>C	c.(4438-4440)ctG>ctC	p.L1480L	POLR1A_ENST00000409681.1_Intron			O95602	RPA1_HUMAN	polymerase (RNA) I polypeptide A, 194kDa	1480					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	63						GGGGCTGCGTCAGGAGGGCGG	0.642000													36	111					0	0	0.819951	0	0
CBX1	10951	broad.mit.edu	37	17	46154251	46154251	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr17:46154251A>G	ENST00000393408.3	-	2	596	c.116T>C	c.(115-117)cTc>cCc	p.L39P	CBX1_ENST00000225603.4_Missense_Mutation_p.L39P|CBX1_ENST00000495350.1_Missense_Mutation_p.L39P	NM_006807.4	NP_006798.1	P83916	CBX1_HUMAN	chromobox homolog 1	39	Chromo 1.					nuclear heterochromatin|nucleoplasm|spindle	chromatin binding|enzyme binding			breast(1)|central_nervous_system(1)|kidney(1)|prostate(1)	4						CCACTTTAGGAGGTACTCCAC	0.463000													3	146					0	0	0.150653	0	0
SVOPL	136306	broad.mit.edu	37	7	138310792	138310792	+	Silent	SNP	G	G	A			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr7:138310792G>A	ENST00000421622.1	-	9	1033	c.825C>T	c.(823-825)gcC>gcT	p.A275A	SVOPL_ENST00000419765.3_Silent_p.A395A|SVOPL_ENST00000463557.1_5'UTR|SVOPL_ENST00000288513.5_Silent_p.A243A|SVOPL_ENST00000436657.1_Silent_p.A243A			Q8N434	SVOPL_HUMAN	SVOP-like	395						integral to membrane	transmembrane transporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	19						CAATCAGGCCGGCACTAGAAA	0.502000													3	38					0	0	0.115264	0	0
CAMSAP3	57662	broad.mit.edu	37	19	7675446	7675446	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr19:7675446C>T	ENST00000446248.2	+	8	1027	c.926C>T	c.(925-927)cCt>cTt	p.P309L	CAMSAP3_ENST00000160298.4_Missense_Mutation_p.P282L	NM_001080429.2	NP_001073898.1	Q9P1Y5	CAMP3_HUMAN	calmodulin regulated spectrin-associated protein family, member 3	282	CH.				epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			cervix(1)|endometrium(7)|kidney(3)|lung(6)|urinary_tract(2)	19						TCTCGCCTTCCTCGTGGCTGC	0.642000													63	164					0	0	0.870114	0	0
ELF2	1998	broad.mit.edu	37	4	139993174	139993174	+	Silent	SNP	A	A	C			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr4:139993174A>C	ENST00000379550.1	-	5	577	c.372T>G	c.(370-372)ccT>ccG	p.P124P	ELF2_ENST00000358635.3_Silent_p.P64P|ELF2_ENST00000394235.2_Intron|ELF2_ENST00000265495.4_Intron|ELF2_ENST00000379549.2_Silent_p.P64P|ELF2_ENST00000510408.1_Intron			Q15723	ELF2_HUMAN	E74-like factor 2 (ets domain transcription factor)	124					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	19	all_hematologic(180;0.162)					TTGATACACAAGGAGGAACAA	0.388000													26	57					0	0	0.681144	0	0
PQLC2	54896	broad.mit.edu	37	1	19653755	19653755	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:19653755C>G	ENST00000375153.3	+	7	1293	c.653C>G	c.(652-654)tCt>tGt	p.S218C	PQLC2_ENST00000400548.2_Missense_Mutation_p.S153C|PQLC2_ENST00000375155.3_Missense_Mutation_p.S218C	NM_001040125.1	NP_001035214.1	Q6ZP29	PQLC2_HUMAN	PQ loop repeat containing 2	218	PQ-loop 2.					integral to membrane				haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|skin(1)|urinary_tract(1)	10		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;1.89e-05)|Kidney(64;0.000177)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		ATCTCCTACTCTCTGTTCGCG	0.602000													9	81					0	0	0.387290	0	0
CYTH4	27128	broad.mit.edu	37	22	37699360	37699360	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr22:37699360C>T	ENST00000248901.6	+	8	800	c.613C>T	c.(613-615)Cgg>Tgg	p.R205W		NM_013385.3	NP_037517.1	Q9UIA0	CYH4_HUMAN	cytohesin 4	205	SEC7.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(2)|stomach(1)	15						TCCCAACGTCCGGGACAGGCC	0.612000													9	52					0	0	0.335167	0	0
SLFN13	146857	broad.mit.edu	37	17	33769076	33769076	+	Silent	SNP	G	G	C			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr17:33769076G>C	ENST00000285013.6	-	5	1703	c.1428C>G	c.(1426-1428)ctC>ctG	p.L476L	SLFN13_ENST00000533791.1_Silent_p.L476L|SLFN13_ENST00000534689.1_Silent_p.L158L|SLFN13_ENST00000542635.1_Silent_p.L476L|SLFN13_ENST00000526861.1_Silent_p.L476L|SLFN13_ENST00000360502.2_Silent_p.L158L	NM_144682.5	NP_653283.3	Q68D06	SLN13_HUMAN	schlafen family member 13	476						intracellular	ATP binding			NS(1)|breast(1)|endometrium(1)|large_intestine(10)|lung(8)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	31				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		CCTGCTCCCTGAGAATGGTGT	0.557000													14	100					0	0	0.479597	0	0
PTPN3	5774	broad.mit.edu	37	9	112145729	112145729	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr9:112145729G>A	ENST00000412145.1	-	18	4516	c.1963C>T	c.(1963-1965)Cga>Tga	p.R655*	PTPN3_ENST00000394827.3_Nonsense_Mutation_p.R254*|PTPN3_ENST00000446349.1_Nonsense_Mutation_p.R610*|PTPN3_ENST00000374541.2_Nonsense_Mutation_p.R786*|PTPN3_ENST00000262539.3_Nonsense_Mutation_p.R632*	NM_001145369.1|NM_001145371.1	NP_001138841.1|NP_001138843.1	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type 3	786	Tyrosine-protein phosphatase.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						AGCATTTCTCGGGACACATAG	0.602000													45	73					0	0	0.853193	0	0
LYST	1130	broad.mit.edu	37	1	235952067	235952067	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:235952067G>A	ENST00000389794.3	-	13	4796	c.4622C>T	c.(4621-4623)tCa>tTa	p.S1541L	LYST_ENST00000389793.2_Missense_Mutation_p.S1541L|LYST_ENST00000536965.1_3'UTR			Q99698	LYST_HUMAN	lysosomal trafficking regulator	1541					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GGATCCCAGTGAAATTATATG	0.408000													11	20					0	0	0.361761	0	0
CASC5	57082	broad.mit.edu	37	15	40914878	40914878	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr15:40914878G>C	ENST00000346991.5	+	11	2884	c.2494G>C	c.(2494-2496)Gaa>Caa	p.E832Q	CASC5_ENST00000399668.2_Missense_Mutation_p.E806Q|CASC5_ENST00000527044.1_3'UTR			Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5	832					acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(13)|lung(16)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		TGTAAAAGTTGAAAAATGTGG	0.358000													6	17					0	0	0.248553	0	0
CDKN2B	1030	broad.mit.edu	37	9	22006036	22006036	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr9:22006036G>A	ENST00000276925.6	-	2	776	c.367C>T	c.(367-369)Cgg>Tgg	p.R123W	CDKN2B_ENST00000380142.4_3'UTR|CDKN2B-AS1_ENST00000468603.2_RNA|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2B-AS1_ENST00000584020.1_RNA|CDKN2B-AS1_ENST00000580576.1_RNA|CDKN2B-AS1_ENST00000581051.1_RNA|CDKN2B-AS1_ENST00000584637.1_RNA|CDKN2B-AS1_ENST00000580467.1_RNA|CDKN2B-AS1_ENST00000585267.1_RNA|CDKN2B-AS1_ENST00000577551.1_RNA|CDKN2B-AS1_ENST00000582301.1_RNA|CDKN2B-AS1_ENST00000584816.1_RNA|CDKN2B-AS1_ENST00000455933.2_RNA|CDKN2B-AS1_ENST00000428597.1_RNA|CDKN2B-AS1_ENST00000584351.1_RNA|CDKN2B-AS1_ENST00000583719.1_RNA|CDKN2B-AS1_ENST00000582072.1_RNA	NM_004936.3|NM_078487.2	NP_004927.2|NP_511042.1	P42772	CDN2B_HUMAN	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	123					cell cycle arrest|cellular response to nutrient|G1 phase of mitotic cell cycle|G2/M transition of mitotic cell cycle|megakaryocyte differentiation|mitotic cell cycle G1/S transition checkpoint|negative regulation of epithelial cell proliferation|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of cyclin-dependent protein kinase activity	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|protein kinase binding	p.0(1)|p.0?(1)		lung(2)	2		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;1.31e-280)|Lung NSC(2;2.28e-131)|all_lung(2;2.11e-123)|Glioma(2;5.66e-57)|all_neural(2;3.05e-50)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;8.01e-33)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00369)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;3.29e-71)|Epithelial(2;9.08e-60)|LUSC - Lung squamous cell carcinoma(2;5.8e-46)|LUAD - Lung adenocarcinoma(2;1.43e-25)|BRCA - Breast invasive adenocarcinoma(2;5.37e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;6.92e-07)|KIRC - Kidney renal clear cell carcinoma(2;8.63e-07)|OV - Ovarian serous cystadenocarcinoma(39;0.014)|COAD - Colon adenocarcinoma(8;0.143)		CGGTGGCCCCGCTCCTCGGCC	0.682000													6	14					0	0	0.278610	0	0
POLR1A	25885	broad.mit.edu	37	2	86258743	86258743	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr2:86258743C>A	ENST00000263857.6	-	30	4666	c.4288G>T	c.(4288-4290)Gag>Tag	p.E1430*	POLR1A_ENST00000409681.1_Nonsense_Mutation_p.E1430*			O95602	RPA1_HUMAN	polymerase (RNA) I polypeptide A, 194kDa	1430					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	63						tcctcttcctcACTCTCATAA	0.547000													18	56					1.67942e-08	1.84406e-08	0.539581	1	0
WWC3	55841	broad.mit.edu	37	X	10094175	10094175	+	Silent	SNP	C	C	A			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chrX:10094175C>A	ENST00000380861.4	+	15	2326	c.1935C>A	c.(1933-1935)ccC>ccA	p.P645P	WWC3_ENST00000454666.1_Silent_p.P645P	NM_015691.3	NP_056506.2	Q9ULE0	WWC3_HUMAN	WWC family member 3	645	C2.									NS(1)|breast(3)|endometrium(10)|kidney(1)|large_intestine(11)|lung(17)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	52						TCTATTTGCCCCCACTGGACT	0.602000													5	191					0.217242	0.227394	0.217242	1	0
UBTF	7343	broad.mit.edu	37	17	42286824	42286824	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr17:42286824C>T	ENST00000302904.4	-	17	2293	c.1801G>A	c.(1801-1803)Ggc>Agc	p.G601S	UBTF_ENST00000436088.1_Missense_Mutation_p.G601S|UBTF_ENST00000527034.1_Missense_Mutation_p.G564S|UBTF_ENST00000343638.5_Missense_Mutation_p.G564S|UBTF_ENST00000393606.3_Missense_Mutation_p.G564S|UBTF_ENST00000526094.1_Missense_Mutation_p.G564S|CTB-175E5.7_ENST00000586560.1_RNA|UBTF_ENST00000529383.1_Missense_Mutation_p.G601S|UBTF_ENST00000533177.1_Missense_Mutation_p.G564S			P17480	UBF1_HUMAN	upstream binding transcription factor, RNA polymerase I	601					positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(10)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)		CAGCGACTGCCGATCTCCACC	0.597000													11	46					0	0	0.387290	0	0
CACNA1B	774	broad.mit.edu	37	9	140811877	140811877	+	Silent	SNP	C	C	G			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr9:140811877C>G	ENST00000371372.1	+	6	1105	c.960C>G	c.(958-960)ctC>ctG	p.L320L	CACNA1B_ENST00000371363.1_Silent_p.L320L|CACNA1B_ENST00000371355.4_Silent_p.L320L|CACNA1B_ENST00000371357.1_Silent_p.L320L|CACNA1B_ENST00000277549.5_5'UTR|CACNA1B_ENST00000277551.2_Silent_p.L320L	NM_000718.3|NM_001243812.1	NP_000709.1|NP_001230741.1	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	320					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CTGACATCCTCTATAATGTGA	0.582000													27	41					0	0	0.740014	0	0
TCEB3B	51224	broad.mit.edu	37	18	44561319	44561319	+	Missense_Mutation	SNP	T	T	C	rs146911955	byFrequency	TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr18:44561319T>C	ENST00000332567.4	-	1	669	c.317A>G	c.(316-318)cAg>cGg	p.Q106R	KATNAL2_ENST00000592005.1_Intron|KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	106					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding	p.Q106R(1)		breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						GGCCTTTTCCTGGTCCTGAAG	0.652000													11	74					0	0	0.361761	0	0
NOXO1	124056	broad.mit.edu	37	16	2029466	2029466	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr16:2029466G>T	ENST00000354249.4	-	7	1144	c.775C>A	c.(775-777)Cgc>Agc	p.R259S	NOXO1_ENST00000566005.1_Missense_Mutation_p.R264S|NOXO1_ENST00000356120.4_Missense_Mutation_p.R260S|NOXO1_ENST00000397280.4_Missense_Mutation_p.R265S|TBL3_ENST00000568546.1_3'UTR	NM_001267721.1|NM_144603.3|NM_172167.2|NM_172168.2	NP_001254650.1|NP_653204.1|NP_751907.1|NP_751908.1	Q8NFA2	NOXO1_HUMAN	NADPH oxidase organizer 1	265	SH3 2.				cell communication|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst	NADPH oxidase complex	enzyme binding|phosphatidylinositol binding|superoxide-generating NADPH oxidase activator activity			lung(2)	2						TCCAACACGCGCACGCGCGCC	0.706000													6	28					2.0095e-06	2.18508e-06	0.248553	1	0
RPP38	10557	broad.mit.edu	37	10	15145354	15145354	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr10:15145354G>A	ENST00000378197.4	+	3	555	c.41G>A	c.(40-42)cGt>cAt	p.R14H	RPP38_ENST00000451677.1_Intron|NMT2_ENST00000466201.1_5'UTR|RPP38_ENST00000378202.5_Missense_Mutation_p.R14H	NM_183005.4	NP_892117.1	P78345	RPP38_HUMAN	ribonuclease P/MRP 38kDa subunit	14					tRNA processing	nucleolar ribonuclease P complex	protein binding|ribonuclease P activity			breast(1)|endometrium(3)|large_intestine(1)|lung(2)|ovary(1)	8						GGATCTCTCCGTAAGACGAGA	0.498000													26	70					0	0	0.681144	0	0
OTOF	9381	broad.mit.edu	37	2	26687829	26687829	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr2:26687829C>T	ENST00000272371.2	-	39	4994	c.4868G>A	c.(4867-4869)gGc>gAc	p.G1623D	OTOF_ENST00000339598.3_Missense_Mutation_p.G856D|OTOF_ENST00000338581.6_Missense_Mutation_p.G856D|OTOF_ENST00000403946.3_Missense_Mutation_p.G1623D|OTOF_ENST00000402415.3_Missense_Mutation_p.G933D	NM_194248.2	NP_919224.1	Q9HC10	OTOF_HUMAN	otoferlin	1623					cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTCCACTTTGCCGTCTTTGCA	0.622000													3	44					0	0	0.115264	0	0
SP1	6667	broad.mit.edu	37	12	53776442	53776442	+	Silent	SNP	C	C	G			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr12:53776442C>G	ENST00000426431.2	+	3	750	c.690C>G	c.(688-690)ccC>ccG	p.P230P	SP1_ENST00000327443.4_Silent_p.P237P	NM_003109.1	NP_003100.1	P08047	SP1_HUMAN	Sp1 transcription factor	237	Transactivation domain A (Gln-rich).				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.00527)		AGGCTGTCCCCCTCCAAGGCC	0.488000													24	61					0	0	0.624587	0	0
SNX27	81609	broad.mit.edu	37	1	151655862	151655862	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:151655862A>G	ENST00000368843.3	+	8	1300	c.1180A>G	c.(1180-1182)Aaa>Gaa	p.K394E	SNX27_ENST00000368838.1_Missense_Mutation_p.K301E|SNX27_ENST00000458013.2_Missense_Mutation_p.K394E	NM_030918.5	NP_112180.4	Q96L92	SNX27_HUMAN	sorting nexin family member 27	394					cell communication|protein transport|signal transduction	cytosol|early endosome	phosphatidylinositol binding|protein binding			central_nervous_system(1)|large_intestine(2)|ovary(2)	5	Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			AGGTTACATCAAAGCAGAAGA	0.358000													8	23					0	0	0.335167	0	0
LOC101927079	101927079	broad.mit.edu	37	15	22332432	22332432	+	RNA	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr15:22332432C>T	ENST00000558896.1	+	0	239																											AAGATTCTAACGTGACAGAAC	0.343000													4	77					0	0	0.278610	0	0
TYR	7299	broad.mit.edu	37	11	88911384	88911384	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr11:88911384C>T	ENST00000263321.5	+	1	765	c.263C>T	c.(262-264)aCc>aTc	p.T88I	TYR_ENST00000526139.1_3'UTR	NM_000372.4	NP_000363.1	P14679	TYRO_HUMAN	tyrosinase	88					eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	48		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	TATAATAGGACCTGCCAGTGC	0.502000													9	36					0	0	0.307466	0	0
RGS5	8490	broad.mit.edu	37	1	163117208	163117208	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:163117208C>G	ENST00000313961.5	-	5	747	c.470G>C	c.(469-471)aGa>aCa	p.R157T	RGS5_ENST00000530507.1_Missense_Mutation_p.R161T|RGS5_ENST00000527988.1_Missense_Mutation_p.R49T|RGS5_ENST00000367903.3_Missense_Mutation_p.R177T	NM_001254749.1|NM_003617.3	NP_001241678.1|NP_003608.1	O15539	RGS5_HUMAN	regulator of G-protein signaling 5	157	RGS.				negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(1)|lung(12)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	20			LUSC - Lung squamous cell carcinoma(543;0.187)			GGCATGGATTCTTTTCTGGGC	0.453000													20	46					0	0	0.575678	0	0
SPTB	6710	broad.mit.edu	37	14	65259855	65259855	+	Silent	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr14:65259855C>T	ENST00000389722.3	-	13	2579	c.2526G>A	c.(2524-2526)caG>caA	p.Q842Q	SPTB_ENST00000556626.1_Silent_p.Q842Q|SPTB_ENST00000542895.1_Silent_p.Q842Q|SPTB_ENST00000389720.3_Silent_p.Q842Q|SPTB_ENST00000389721.5_Silent_p.Q842Q	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	842					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CCTGCAGCCTCTGCTGACGCA	0.627000													13	50					0	0	0.435327	0	0
LARGE	9215	broad.mit.edu	37	22	33780235	33780235	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr22:33780235C>G	ENST00000354992.2	-	9	1519	c.948G>C	c.(946-948)tgG>tgC	p.W316C	LARGE_ENST00000337431.2_Missense_Mutation_p.W316C|LARGE_ENST00000402320.1_Missense_Mutation_p.W316C|LARGE_ENST00000437602.2_Missense_Mutation_p.W316C|LARGE_ENST00000397394.2_Missense_Mutation_p.W316C|LARGE_ENST00000452586.2_Missense_Mutation_p.W115C	NM_004737.4	NP_004728.1	O95461	LARGE_HUMAN	like-glycosyltransferase	316					glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Lung NSC(1;0.219)				CGGTCAGCCTCCACATCTGCT	0.488000													35	85					0	0	0.779181	0	0
FGD5	152273	broad.mit.edu	37	3	14862507	14862507	+	Silent	SNP	G	G	A			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr3:14862507G>A	ENST00000285046.5	+	1	2039	c.1929G>A	c.(1927-1929)ccG>ccA	p.P643P	FGD5_ENST00000543601.1_Silent_p.P402P	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	643					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						GCGACTCCCCGGACAAGTACA	0.507000													21	45					0	0	0.608945	0	0
C12orf45	121053	broad.mit.edu	37	12	105381948	105381948	+	Missense_Mutation	SNP	T	T	A			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr12:105381948T>A	ENST00000552951.1	+	2	162	c.119T>A	c.(118-120)aTa>aAa	p.I40K	C12orf45_ENST00000280749.5_Missense_Mutation_p.I40K	NM_152318.2	NP_689531.2	Q8N5I9	CL045_HUMAN	chromosome 12 open reading frame 45	40										large_intestine(1)|lung(2)	3						TTTTCAGGTATATGGGACAGG	0.438000													7	10					0	0	0.248553	0	0
GGT1	2678	broad.mit.edu	37	22	25011027	25011027	+	Silent	SNP	C	C	T	rs112364951	by1000genomes	TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr22:25011027C>T	ENST00000400382.1	+	7	1070	c.315C>T	c.(313-315)aaC>aaT	p.N105N	GGT1_ENST00000400380.1_Silent_p.N105N|GGT1_ENST00000400383.1_Silent_p.N105N|GGT1_ENST00000248923.4_Silent_p.N105N|GGT1_ENST00000406383.2_Silent_p.N105N			P19440	GGT1_HUMAN	gamma-glutamyltransferase 1	105					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding			breast(1)|endometrium(2)|kidney(14)|large_intestine(2)|lung(6)|pancreas(1)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	40					Glutathione(DB00143)	AGGTCATCAACGCCCGCGAGG	0.637000													4	60					0	0	0.150653	0	0
CARD14	79092	broad.mit.edu	37	17	78166304	78166304	+	Silent	SNP	C	C	G			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr17:78166304C>G	ENST00000573882.1	+	11	1778	c.1242C>G	c.(1240-1242)ctC>ctG	p.L414L	CARD14_ENST00000573754.1_3'UTR|CARD14_ENST00000344227.2_Silent_p.L414L|CARD14_ENST00000570421.1_Silent_p.L414L|CARD14_ENST00000392434.2_Silent_p.L177L			Q9BXL6	CAR14_HUMAN	caspase recruitment domain family, member 14	414					activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			NS(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(5)|prostate(1)|skin(1)	23	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			TTTGGCAGCTCAAGCAGGAAG	0.612000													19	59					0	0	0.575678	0	0
TTLL5	23093	broad.mit.edu	37	14	76186104	76186104	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr14:76186104A>G	ENST00000298832.9	+	11	1074	c.869A>G	c.(868-870)tAt>tGt	p.Y290C	TTLL5_ENST00000555422.1_Intron|TTLL5_ENST00000557636.1_Missense_Mutation_p.Y290C	NM_015072.4	NP_055887.3	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	290	TTL.				protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			NS(2)|breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(3)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	50				BRCA - Breast invasive adenocarcinoma(234;0.029)		GTGGAGGATTATGGAAACAAA	0.388000													2	23					0	0	0.115264	0	0
PCDHA9	9752	broad.mit.edu	37	5	140229486	140229486	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr5:140229486C>T	ENST00000378122.3	+	1	2130	c.1406C>T	c.(1405-1407)cCg>cTg	p.P469L	PCDHA8_ENST00000531613.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA9_ENST00000532602.1_Missense_Mutation_p.P469L|PCDHA5_ENST00000529619.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGAACAACCCGCCGGGCTGC	0.672000													41	87					0	0	0.834066	0	0
LSM14B	149986	broad.mit.edu	37	20	60697745	60697745	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr20:60697745C>T	ENST00000253001.4	+	1	229	c.23C>T	c.(22-24)cCg>cTg	p.P8L	LSM14B_ENST00000279068.6_Missense_Mutation_p.P8L|LSM14B_ENST00000370915.1_Missense_Mutation_p.P8L			Q9BX40	LS14B_HUMAN	LSM14B, SCD6 homolog B (S. cerevisiae)	8					multicellular organismal development|regulation of translation	ribonucleoprotein complex				endometrium(3)|kidney(1)|lung(4)	8	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			TCAGGCACCCCGTATCTGGGC	0.726000													6	33					0	0	0.217242	0	0
GTF2I	2969	broad.mit.edu	37	7	74148279	74148279	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr7:74148279A>G	ENST00000324896.4	+	16	1708	c.1319A>G	c.(1318-1320)aAt>aGt	p.N440S	GTF2I_ENST00000346152.4_Missense_Mutation_p.N419S|GTF2I_ENST00000416070.1_Missense_Mutation_p.N399S|GTF2I_ENST00000353920.4_Missense_Mutation_p.N420S	NM_032999.2	NP_127492.1	P78347	GTF2I_HUMAN	general transcription factor IIi	440					negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity	p.N440S(7)		NS(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19						GAGCTTCTGAATTCAACACGT	0.358000													3	97					0	0	0.115264	0	0
GFI1B	8328	broad.mit.edu	37	9	135866388	135866388	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr9:135866388G>A	ENST00000339463.3	+	11	1763	c.944G>A	c.(943-945)cGc>cAc	p.R315H	GFI1B_ENST00000450530.1_Missense_Mutation_p.R315H|GFI1B_ENST00000372122.1_Missense_Mutation_p.R315H|GFI1B_ENST00000534944.1_Missense_Mutation_p.R269H|GFI1B_ENST00000372124.1_Missense_Mutation_p.R269H|GFI1B_ENST00000372123.1_Missense_Mutation_p.R269H			Q5VTD9	GFI1B_HUMAN	growth factor independent 1B transcription repressor	315	Interaction with ARIH2.|Mediates interaction with GATA1.				cell proliferation|chromatin modification|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|zinc ion binding	p.R315H(1)		central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)	21				OV - Ovarian serous cystadenocarcinoma(145;9.04e-07)|Epithelial(140;1.17e-05)		GGCTTCCAGCGCAAGGTGGAC	0.647000													3	53					0	0	0.150653	0	0
SEMA3D	223117	broad.mit.edu	37	7	84751133	84751133	+	Silent	SNP	T	T	C			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr7:84751133T>C	ENST00000284136.6	-	1	118	c.75A>G	c.(73-75)ctA>ctG	p.L25L	SEMA3D_ENST00000444867.1_Silent_p.L25L	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	25					cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						TGGTCATGCTTAGCATCATCA	0.333000													19	31					0	0	0.575678	0	0
CACNA1E	777	broad.mit.edu	37	1	181707501	181707501	+	Splice_Site	SNP	A	A	G			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:181707501A>G	ENST00000526775.1	+	23	3660		c.e23-1		CACNA1E_ENST00000357570.5_Splice_Site|CACNA1E_ENST00000367570.1_Splice_Site|CACNA1E_ENST00000367573.2_Splice_Site|CACNA1E_ENST00000360108.3_Splice_Site|CACNA1E_ENST00000367567.4_Splice_Site|CACNA1E_ENST00000358338.5_Splice_Site	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit						energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						TGTGTCTTTCAGGTCCTGAGG	0.488000													5	233					0	0	0.217242	0	0
PCDHB2	56133	broad.mit.edu	37	5	140476332	140476332	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr5:140476332C>T	ENST00000194155.4	+	1	2106	c.1958C>T	c.(1957-1959)cCg>cTg	p.P653L		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		653	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGCGAGCCTCCGCGCTCGGCC	0.721000													24	68					0	0	0.667858	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77465414	77465414	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr16:77465414C>G	ENST00000282849.5	-	3	691	c.273G>C	c.(271-273)caG>caC	p.Q91H	ADAMTS18_ENST00000567121.1_5'UTR	NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	91					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TTCTGGCATTCTGCGCCGATC	0.478000													59	160					0	0	0.870114	0	0
HERC2P3	283755	broad.mit.edu	37	15	20645758	20645758	+	RNA	SNP	G	G	A			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr15:20645758G>A	ENST00000428453.1	-	0	3007																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						AGTGAAGGGTGCGTGCCCTTC	0.607000													5	32					0	0	0.217242	0	0
CX3CL1	6376	broad.mit.edu	37	16	57416628	57416628	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr16:57416628C>T	ENST00000565912.1	+	2	3470	c.764C>T	c.(763-765)tCa>tTa	p.S255L	CX3CL1_ENST00000563383.1_Missense_Mutation_p.S299L|CX3CL1_ENST00000006053.6_Missense_Mutation_p.S293L			P78423	X3CL1_HUMAN	chemokine (C-X3-C motif) ligand 1	293	Mucin-like stalk.				cell adhesion|cytokine-mediated signaling pathway|defense response|immune response|leukocyte adhesive activation|positive regulation of calcium-independent cell-cell adhesion|positive regulation of inflammatory response	cell surface|extracellular space|integral to membrane|plasma membrane	chemokine activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)	5						CCTGTCTCCTCAGAAGGGACC	0.672000													19	55					0	0	0.557998	0	0
TTF1	7270	broad.mit.edu	37	9	135263551	135263551	+	Missense_Mutation	SNP	G	G	A	rs112758716		TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr9:135263551G>A	ENST00000334270.2	-	8	2326	c.2287C>T	c.(2287-2289)Cgg>Tgg	p.R763W		NM_001205296.1|NM_007344.3	NP_001192225.1|NP_031370.2	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase I	763					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		ACCTTGGCCCGCAGGGCATTC	0.408000													3	38					0	0	0.115264	0	0
TCEB3B	51224	broad.mit.edu	37	18	44561321	44561321	+	Missense_Mutation	SNP	G	G	C	rs138936821	byFrequency	TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr18:44561321G>C	ENST00000332567.4	-	1	667	c.315C>G	c.(313-315)gaC>gaG	p.D105E	KATNAL2_ENST00000592005.1_Intron|KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	105					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding	p.D105E(1)		breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						CCTTTTCCTGGTCCTGAAGAG	0.662000													10	71					0	0	0.335167	0	0
PLSCR1	5359	broad.mit.edu	37	3	146251317	146251317	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr3:146251317G>T	ENST00000342435.4	-	3	444	c.34C>A	c.(34-36)Cac>Aac	p.H12N	PLSCR1_ENST00000448787.2_Silent_p.L3L|PLSCR1_ENST00000448205.1_5'UTR|PLSCR1_ENST00000487389.1_Missense_Mutation_p.H5N	NM_021105.2	NP_066928.1	O15162	PLS1_HUMAN	phospholipid scramblase 1	12					phospholipid scrambling|platelet activation|response to virus	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)	15						GTTTCCGGGTGAGAAGCATTC	0.353000													22	82					3.62473e-10	4.0195e-10	0.608945	1	0
INPP5A	3632	broad.mit.edu	37	10	134563026	134563026	+	Silent	SNP	C	C	G			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr10:134563026C>G	ENST00000368594.3	+	10	1015	c.738C>G	c.(736-738)ctC>ctG	p.L246L	INPP5A_ENST00000368593.3_Silent_p.L246L	NM_005539.3	NP_005530.3	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase, 40kDa	246					cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			cervix(1)|kidney(1)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		TGCAGACGCTCTGCACAAAAG	0.612000													23	47					0	0	0.681144	0	0
PCDHB4	56131	broad.mit.edu	37	5	140503159	140503159	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr5:140503159G>A	ENST00000194152.1	+	1	1579	c.1579G>A	c.(1579-1581)Gag>Aag	p.E527K		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		527	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCAGGCGTTCGAGTTCCGCGT	0.677000													42	85					0	0	0.827153	0	0
KLHL7	55975	broad.mit.edu	37	7	23164704	23164704	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr7:23164704G>A	ENST00000339077.5	+	4	598	c.355G>A	c.(355-357)Gat>Aat	p.D119N	KLHL7_ENST00000539124.1_Missense_Mutation_p.D43N|KLHL7_ENST00000545443.1_Missense_Mutation_p.D97N|KLHL7_ENST00000545771.1_Missense_Mutation_p.D97N|KLHL7_ENST00000479288.1_Intron|KLHL7_ENST00000322275.5_Missense_Mutation_p.D119N|KLHL7_ENST00000410047.1_Missense_Mutation_p.D97N|KLHL7_ENST00000542558.1_Intron|KLHL7_ENST00000409689.1_Missense_Mutation_p.D71N|KLHL7_ENST00000322231.7_Missense_Mutation_p.D97N	NM_001031710.2	NP_001026880.2	Q8IXQ5	KLHL7_HUMAN	kelch-like family member 7							Golgi apparatus|nucleolus|plasma membrane				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						GTCTTTGCTGGATGCAGCAAA	0.318000													16	28					0	0	0.500413	0	0
CYP4Z1	199974	broad.mit.edu	37	1	47583503	47583503	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:47583503G>T	ENST00000334194.3	+	12	1418	c.1415G>T	c.(1414-1416)cGc>cTc	p.R472L	CYP4Z1_ENST00000471598.1_3'UTR|CYP4A22-AS1_ENST00000444042.2_lincRNA	NM_178134.2	NP_835235.1	Q86W10	CP4Z1_HUMAN	cytochrome P450, family 4, subfamily Z, polypeptide 1	472						endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			cervix(1)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	11						ACTCTGCTCCGCTTCAAGCTG	0.468000													19	35					9.7654e-05	0.000105166	0.557998	1	0
SEC22B	9554	broad.mit.edu	37	1	145103956	145103956	+	RNA	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:145103956C>T	ENST00000453618.1	+	0	451							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										GTAACTCTTTCGAAAGTTGAA	0.388000													3	20					0	0	0.184627	0	0
PDXDC2P	283970	broad.mit.edu	37	16	70065826	70065826	+	RNA	SNP	T	T	C	rs3169319	by1000genomes	TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr16:70065826T>C	ENST00000531894.1	-	0	796					NR_003610.1													p.M209V(4)									GATCCAAACATAGTGTTACAG	0.453000													3	111					0	0	0.115264	0	0
BOD1L1	259282	broad.mit.edu	37	4	13601146	13601146	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr4:13601146C>A	ENST00000040738.5	-	10	7513	c.7378G>T	c.(7378-7380)Gaa>Taa	p.E2460*		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	2460							DNA binding										TTCTTCTCTTCTGCATTTATG	0.468000											OREG0016115	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	60					2.39187e-15	2.6789e-15	0.575678	1	0
HAO2	51179	broad.mit.edu	37	1	119923746	119923746	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:119923746C>T	ENST00000361035.4	+	3	360	c.77C>T	c.(76-78)gCg>gTg	p.A26V	HAO2_ENST00000325945.3_Missense_Mutation_p.A13V			Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2 (long chain)	13	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		CAGGCCCATGCGCGAGAGCAG	0.473000													4	144					0	0	0.184627	0	0
HIST1H1D	3007	broad.mit.edu	37	6	26234607	26234607	+	Silent	SNP	T	T	C			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr6:26234607T>C	ENST00000244534.5	-	1	609	c.555A>G	c.(553-555)aaA>aaG	p.K185K		NM_005320.2	NP_005311.1	P16402	H13_HUMAN	histone cluster 1, H1d	185					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	23		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				TCTTGGCAGCTTTTTTTGGCT	0.522000													3	131					0	0	0.150653	0	0
TYMP	1890	broad.mit.edu	37	22	50968116	50968116	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr22:50968116C>T	ENST00000252029.3	-	2	185	c.23G>A	c.(22-24)gGa>gAa	p.G8E	TYMP_ENST00000395681.1_Missense_Mutation_p.G8E|TYMP_ENST00000395678.3_Missense_Mutation_p.G8E|TYMP_ENST00000395680.1_Missense_Mutation_p.G8E	NM_001113755.2|NM_001113756.2|NM_001257988.1|NM_001257989.1|NM_001953.4	NP_001107227.1|NP_001107228.1|NP_001244917.1|NP_001244918.1|NP_001944.1	P19971	TYPH_HUMAN	thymidine phosphorylase	8					angiogenesis|cell differentiation|chemotaxis|DNA replication|mitochondrial genome maintenance|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|pyrimidine nucleotide metabolic process	cytosol	growth factor activity|platelet-derived growth factor receptor binding|pyrimidine-nucleoside phosphorylase activity|thymidine phosphorylase activity			large_intestine(1)|lung(2)|ovary(1)|prostate(1)	5		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)	Capecitabine(DB01101)|Docetaxel(DB01248)|Floxuridine(DB00322)|Fluorouracil(DB00544)|Sulfasalazine(DB00795)|Tamoxifen(DB00675)	GGCCCCGGTTCCCGGGGTCAT	0.716000													4	25					0	0	0.184627	0	0
ZNF91	7644	broad.mit.edu	37	19	23543307	23543307	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr19:23543307G>A	ENST00000300619.7	-	4	2679	c.2474C>T	c.(2473-2475)cCc>cTc	p.P825L	ZNF91_ENST00000599743.1_Intron|ZNF91_ENST00000397082.2_Missense_Mutation_p.P793L	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	825						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				ACATTTGTAGGGTTTCTCTCC	0.403000													11	52					0	0	0.387290	0	0
BAGE2	85319	broad.mit.edu	37	21	11039390	11039390	+	RNA	SNP	T	T	C			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr21:11039390T>C	ENST00000470054.1	-	0	813									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTCTTCACTATCAGCCTCATT	0.318000													4	179					0	0	0.150653	0	0
HEATR1	55127	broad.mit.edu	37	1	236716964	236716964	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:236716964A>G	ENST00000366582.3	-	43	6268	c.6154T>C	c.(6154-6156)Ttt>Ctt	p.F2052L	HEATR1_ENST00000366581.2_Missense_Mutation_p.F1971L	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	2052					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			GCCACCGAAAACTGTGCGATG	0.493000													19	58					0	0	0.812448	0	0
PCDH18	54510	broad.mit.edu	37	4	138451062	138451062	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr4:138451062C>G	ENST00000344876.4	-	1	2567	c.2181G>C	c.(2179-2181)gaG>gaC	p.E727D	PCDH18_ENST00000511115.1_Intron|PCDH18_ENST00000510305.1_Intron|PCDH18_ENST00000507846.1_Missense_Mutation_p.E507D|PCDH18_ENST00000412923.2_Missense_Mutation_p.E727D	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	727					brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					TGTCTTTCTTCTCGCGGTTAC	0.448000													23	43					0	0	0.624587	0	0
HERC2	8924	broad.mit.edu	37	15	28467317	28467317	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr15:28467317G>C	ENST00000261609.7	-	36	5617	c.5509C>G	c.(5509-5511)Caa>Gaa	p.Q1837E		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	1837					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GAAGCACCTTGAGCAGAAGCA	0.493000													8	26					0	0	0.387290	0	0
RHOA	387	broad.mit.edu	37	3	49397710	49397710	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr3:49397710C>T	ENST00000418115.1	-	5	898	c.514G>A	c.(514-516)Gaa>Aaa	p.E172K	RHOA_ENST00000422781.1_3'UTR|RHOA_ENST00000454011.2_3'UTR	NM_001664.2	NP_001655.1	P61586	RHOA_HUMAN	ras homolog family member A	172					axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			cervix(1)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	12				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	GTAGCCATTTCAAAAACCTCT	0.483000													20	91					0	0	0.592651	0	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													3	40					0	0	0.150653	0	0
CD164	8763	broad.mit.edu	37	6	109691643	109691643	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr6:109691643G>C	ENST00000310786.4	-	5	463	c.398C>G	c.(397-399)tCt>tGt	p.S133C	CD164_ENST00000504373.1_Missense_Mutation_p.S99C|CD164_ENST00000368961.5_Intron|CD164_ENST00000506649.1_5'UTR|CD164_ENST00000413644.2_Missense_Mutation_p.S133C|CD164_ENST00000324953.5_Intron|CD164_ENST00000512821.1_Missense_Mutation_p.S133C|CD164_ENST00000275080.7_Missense_Mutation_p.S120C	NM_001142404.1|NM_006016.4	NP_001135876.1|NP_006007.2	Q04900	MUC24_HUMAN	CD164 molecule, sialomucin	133	Thr-rich.				hemopoiesis|heterophilic cell-cell adhesion|immune response|muscle organ development|negative regulation of cell adhesion|negative regulation of cell proliferation|signal transduction	endosome membrane|extracellular region|integral to plasma membrane|lysosomal membrane	protein binding			breast(1)|lung(2)	3		all_cancers(87;4.65e-22)|all_epithelial(87;2.54e-20)|all_lung(197;1.6e-05)|Lung NSC(302;2.92e-05)|Colorectal(196;3.46e-05)|Ovarian(999;0.0175)		Epithelial(106;7.83e-46)|all cancers(137;1.15e-45)|OV - Ovarian serous cystadenocarcinoma(136;2.89e-26)|BRCA - Breast invasive adenocarcinoma(108;0.00128)|GBM - Glioblastoma multiforme(226;0.16)		GGAAGTTGTAGAAGGGGAGGG	0.378000													4	21					0	0	0.184627	0	0
DENND4A	10260	broad.mit.edu	37	15	65988761	65988761	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr15:65988761C>T	ENST00000443035.3	-	22	3237	c.3022G>A	c.(3022-3024)Gtt>Att	p.V1008I	DENND4A_ENST00000431932.2_Missense_Mutation_p.V965I	NM_001144823.1	NP_001138295.1	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A	965					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(11)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	51						GTGAGGCGAACGATACTGGAA	0.383000													5	26					0	0	0.217242	0	0
COL18A1	80781	broad.mit.edu	37	21	46914788	46914788	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr21:46914788C>T	ENST00000359759.4	+	27	3658	c.3637C>T	c.(3637-3639)Cgg>Tgg	p.R1213W	COL18A1_ENST00000355480.5_Missense_Mutation_p.R978W|COL18A1_ENST00000459895.1_3'UTR|COL18A1_ENST00000400337.2_Missense_Mutation_p.R798W			P39060	COIA1_HUMAN	collagen, type XVIII, alpha 1	1213	Triple-helical region 6 (COL6).				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		TCCATACGGACGGCCGGGGTA	0.682000													7	22					0	0	0.307466	0	0
SORCS1	114815	broad.mit.edu	37	10	108380301	108380301	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr10:108380301T>C	ENST00000263054.6	-	20	2688	c.2681A>G	c.(2680-2682)cAc>cGc	p.H894R	SORCS1_ENST00000369698.1_Missense_Mutation_p.H429R|SORCS1_ENST00000344440.6_Missense_Mutation_p.H894R	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	894	PKD.					integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		AAGAGACAGGTGCACGTGCTC	0.557000													17	30					0	0	0.520397	0	0
VARS	7407	broad.mit.edu	37	6	31760629	31760629	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr6:31760629C>T	ENST00000375663.3	-	4	1006	c.566G>A	c.(565-567)cGc>cAc	p.R189H	VARS_ENST00000444930.2_5'UTR	NM_006295.2	NP_006286.1	P26640	SYVC_HUMAN	valyl-tRNA synthetase	189	GST C-terminal.				translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	30					L-Valine(DB00161)	GACAAACCAGCGAGTCACATT	0.547000													12	46					0	0	0.387290	0	0
PCDHA4	56144	broad.mit.edu	37	5	140188974	140188974	+	Silent	SNP	G	G	A			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr5:140188974G>A	ENST00000530339.1	+	1	2202	c.2202G>A	c.(2200-2202)ccG>ccA	p.P734P	PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Silent_p.P734P|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000356878.4_Silent_p.P734P	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGCGCTCCGGGCAAGCCCA	0.682000													22	50					0	0	0.592651	0	0
HDAC1	3065	broad.mit.edu	37	1	32797278	32797278	+	Splice_Site	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:32797278C>T	ENST00000373548.3	+	11	1174	c.1090C>T	c.(1090-1092)Cag>Tag	p.Q364*	HDAC1_ENST00000373541.2_Splice_Site_p.Q171*|HDAC1_ENST00000490081.1_3'UTR	NM_004964.2	NP_004955.2	Q13547	HDAC1_HUMAN	histone deacetylase 1	364					anti-apoptosis|blood coagulation|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|histone H3 deacetylation|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of androgen receptor signaling pathway|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytosol|NuRD complex|Sin3 complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|identical protein binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|RNA polymerase II transcription corepressor activity|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	18		Breast(348;0.000523)|Lung NSC(340;0.000992)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Lung SC(1967;0.113)		KIRC - Kidney renal clear cell carcinoma(1967;0.138)	Vorinostat(DB02546)	TGGCCACAGACAGCGACTGTT	0.552000													26	89					0	0	0.717897	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140746095	140746095	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr5:140746095C>T	ENST00000518069.1	+	1	2198	c.2198C>T	c.(2197-2199)gCg>gTg	p.A733V	PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB2_ENST00000522605.1_Intron	NM_018918.2|NM_032054.1	NP_061741.1|NP_114443.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|upper_aerodigestive_tract(3)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCAGGTTGGCGGGTGTGCCC	0.632000													4	149					0	0	0.150653	0	0
ADPRH	141	broad.mit.edu	37	3	119305346	119305346	+	Silent	SNP	G	G	A			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr3:119305346G>A	ENST00000478399.1	+	3	1918	c.513G>A	c.(511-513)ggG>ggA	p.G171G	ADPRH_ENST00000478927.1_Silent_p.G171G|ADPRH_ENST00000357003.3_Silent_p.G171G|ADPRH_ENST00000471850.1_3'UTR|ADPRH_ENST00000465513.1_Silent_p.G171G			P54922	ADPRH_HUMAN	ADP-ribosylarginine hydrolase	171					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			breast(1)|kidney(1)|lung(10)|ovary(1)	13		Lung NSC(201;0.0977)		GBM - Glioblastoma multiforme(114;0.23)		GCTACCTGGGGGCCCTTGCGT	0.542000													38	115					0	0	0.796494	0	0
ABCC10	89845	broad.mit.edu	37	6	43403844	43403844	+	Silent	SNP	A	A	G			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr6:43403844A>G	ENST00000244533.3	+	4	2009	c.1650A>G	c.(1648-1650)ttA>ttG	p.L550L	ABCC10_ENST00000372530.4_Intron	NM_033450.2	NP_258261.2	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 10	589	ABC transmembrane type-1 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(8)|lung(21)|ovary(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GTGGTAGATTAGGAGCCCAAA	0.488000													3	159					0	0	0.150653	0	0
OR2T33	391195	broad.mit.edu	37	1	248436878	248436878	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:248436878G>A	ENST00000318021.2	-	1	260	c.239C>T	c.(238-240)gCg>gTg	p.A80V		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	80					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GTAGTCAGCCGCCATTTTGGG	0.567000													51	163					0	0	0.870114	0	0
ATG14	22863	broad.mit.edu	37	14	55836491	55836491	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr14:55836491C>T	ENST00000247178.5	-	10	1360	c.1325G>A	c.(1324-1326)cGg>cAg	p.R442Q		NM_014924.4	NP_055739.2	Q6ZNE5	BAKOR_HUMAN	autophagy related 14	442					autophagic vacuole assembly|positive regulation of autophagy	autophagic vacuole|endoplasmic reticulum|pre-autophagosomal structure membrane	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(2)	13						ATCACAAAACCGGGGACTAGG	0.587000													16	43					0	0	0.479597	0	0
QSER1	79832	broad.mit.edu	37	11	32994985	32994985	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr11:32994985G>A	ENST00000399302.2	+	11	5196	c.4861G>A	c.(4861-4863)Gat>Aat	p.D1621N	QSER1_ENST00000527788.1_Missense_Mutation_p.D1382N	NM_001076786.1	NP_001070254.1	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	1621										breast(5)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	48	Breast(20;0.158)					AATTACTCGAGATTCTAAAGC	0.333000													23	30					0	0	0.624587	0	0
SLC6A19	340024	broad.mit.edu	37	5	1214154	1214154	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr5:1214154C>G	ENST00000304460.10	+	6	917	c.861C>G	c.(859-861)atC>atG	p.I287M		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	287					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GGGGCCTCATCTCCTTCTCCA	0.622000													24	85					0	0	0.667858	0	0
POTEC	388468	broad.mit.edu	37	18	14513764	14513764	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr18:14513764C>T	ENST00000358970.5	-	10	1429	c.1430G>A	c.(1429-1431)cGg>cAg	p.R477Q		NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	477								p.R477Q(12)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						AAGTTGTTTCCGGGTATCATT	0.358000													4	49					0	0	0.150653	0	0
KCNA6	3742	broad.mit.edu	37	12	4919301	4919301	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr12:4919301G>A	ENST00000433855.1	+	1	960	c.94G>A	c.(94-96)Ggc>Agc	p.G32S	KCNA6_ENST00000280684.3_Missense_Mutation_p.G32S	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	32						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						CCCGGAGGCCGGCGGGGGCGG	0.662000										HNSCC(72;0.22)			27	56					0	0	0.750413	0	0
IL6ST	3572	broad.mit.edu	37	5	55252048	55252048	+	Nonstop_Mutation	SNP	C	C	G			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr5:55252048C>G	ENST00000381287.4	-	7	1024	c.989G>C	c.(988-990)tGa>tCa	p.*330S	IL6ST_ENST00000522633.2_Nonstop_Mutation_p.*330S|IL6ST_ENST00000381298.2_Missense_Mutation_p.E358Q|IL6ST_ENST00000336909.5_Missense_Mutation_p.E358Q|IL6ST_ENST00000381294.3_Missense_Mutation_p.E358Q|IL6ST_ENST00000536319.1_Nonstop_Mutation_p.*330S|IL6ST_ENST00000381293.2_Intron|IL6ST_ENST00000502326.3_Missense_Mutation_p.E358Q|IL6ST_ENST00000381286.3_Intron			P40189	IL6RB_HUMAN	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0	Fibronectin type-III 3.				interleukin-6-mediated signaling pathway|leukemia inhibitory factor signaling pathway|negative regulation of interleukin-6-mediated signaling pathway|positive regulation of anti-apoptosis|positive regulation of cardiac muscle hypertrophy|positive regulation of osteoblast differentiation|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation vascular endothelial growth factor production	ciliary neurotrophic factor receptor complex|extracellular region|extracellular space|interleukin-6 receptor complex|oncostatin-M receptor complex	ciliary neurotrophic factor receptor activity|ciliary neurotrophic factor receptor binding|growth factor binding|protein homodimerization activity			breast(2)|endometrium(5)|kidney(5)|large_intestine(4)|liver(2)|lung(1)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	26		Lung NSC(810;8.69e-05)|Prostate(74;0.00308)|Breast(144;0.0544)|Ovarian(174;0.223)				CCATTGGCTTCAAAAGGAGGC	0.284000			O		hepatocellular ca								7	35					0	0	0.248553	0	0
POLR1A	25885	broad.mit.edu	37	2	86258707	86258707	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr2:86258707C>T	ENST00000263857.6	-	30	4702	c.4324G>A	c.(4324-4326)Gat>Aat	p.D1442N	POLR1A_ENST00000409681.1_Missense_Mutation_p.D1442N			O95602	RPA1_HUMAN	polymerase (RNA) I polypeptide A, 194kDa	1442					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	63						atgtcttcatcgtcgttctcc	0.557000													17	53					0	0	0.539581	0	0
MPND	84954	broad.mit.edu	37	19	4357557	4357557	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr19:4357557C>G	ENST00000599840.1	+	10	1246	c.1211C>G	c.(1210-1212)cCt>cGt	p.P404R	MPND_ENST00000359935.4_Missense_Mutation_p.P354R|AC007292.3_ENST00000593524.1_RNA|MPND_ENST00000262966.8_Missense_Mutation_p.P404R			Q8N594	MPND_HUMAN	MPN domain containing	404							peptidase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|ovary(1)	8				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGATCTCACCTTTCTGGGTG	0.672000													7	26					0	0	0.411799	0	0
BOD1L1	259282	broad.mit.edu	37	4	13601587	13601587	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr4:13601587C>T	ENST00000040738.5	-	10	7072	c.6937G>A	c.(6937-6939)Gaa>Aaa	p.E2313K		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	2313							DNA binding										AGCCGATCTTCATCCTGGAGG	0.522000													10	6					0	0	0.335167	0	0
HMCN1	83872	broad.mit.edu	37	1	186024541	186024541	+	Silent	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:186024541C>T	ENST00000271588.4	+	45	7108	c.6879C>T	c.(6877-6879)acC>acT	p.T2293T	HMCN1_ENST00000367492.2_Silent_p.T2293T	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	2293	Ig-like C2-type 21.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						CAACCATAACCAACAGTGGCA	0.443000													19	37					0	0	0.608945	0	0
CDH26	60437	broad.mit.edu	37	20	58545166	58545166	+	Silent	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr20:58545166C>T	ENST00000348616.4	+	3	456	c.156C>T	c.(154-156)tcC>tcT	p.S52S	CDH26_ENST00000244047.5_Silent_p.S52S	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	52	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			TACGGCGATCCAAGAGAAGAT	0.502000													24	112					0	0	0.693898	0	0
MIPOL1	145282	broad.mit.edu	37	14	37892073	37892073	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr14:37892073C>T	ENST00000327441.7	+	12	1416	c.950C>T	c.(949-951)tCt>tTt	p.S317F	MIPOL1_ENST00000536774.1_Missense_Mutation_p.S136F|MIPOL1_ENST00000556451.1_Missense_Mutation_p.S286F|MIPOL1_ENST00000539062.2_Missense_Mutation_p.S286F|MIPOL1_ENST00000537471.1_Missense_Mutation_p.S317F|MIPOL1_ENST00000396294.2_Missense_Mutation_p.S317F|MIPOL1_ENST00000545536.1_Missense_Mutation_p.S286F	NM_001195296.1|NM_001195297.1|NM_138731.6	NP_001182225.1|NP_001182226.1|NP_620059.1	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1	317										breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		AAGTTGTTATCTATGCAACAA	0.323000													7	14					0	0	0.335167	0	0
PLXNB2	23654	broad.mit.edu	37	22	50718455	50718455	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr22:50718455G>C	ENST00000449103.1	-	26	4361	c.4221C>G	c.(4219-4221)atC>atG	p.I1407M	PLXNB2_ENST00000359337.4_Missense_Mutation_p.I1407M			O15031	PLXB2_HUMAN	plexin B2	1407					regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GGTACAGGCAGATGGACATCC	0.607000													10	46					0	0	0.335167	0	0
CD19	930	broad.mit.edu	37	16	28948412	28948412	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr16:28948412G>A	ENST00000538922.1	+	8	1215	c.1153G>A	c.(1153-1155)Gtc>Atc	p.V385I	CD19_ENST00000567541.1_Missense_Mutation_p.V385I|CD19_ENST00000324662.3_Missense_Mutation_p.V385I	NM_001178098.1|NM_001770.5	NP_001171569.1|NP_001761.3	P15391	CD19_HUMAN	CD19 molecule	385					cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(4)|urinary_tract(1)	29						GAGCAGCGACGTCCAGGCGGA	0.682000													4	17					0	0	0.184627	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232601037	232601037	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:232601037G>A	ENST00000366630.1	-	8	2727	c.2369C>T	c.(2368-2370)gCa>gTa	p.A790V	SIPA1L2_ENST00000262861.4_Missense_Mutation_p.A790V			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	790	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TTTATGGGCTGCATTTTCTGC	0.488000													4	138					0	0	0.184627	0	0
TNFAIP3	7128	broad.mit.edu	37	6	138198247	138198247	+	Silent	SNP	G	G	A			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr6:138198247G>A	ENST00000237289.4	+	6	906	c.840G>A	c.(838-840)cgG>cgA	p.R280R	TNFAIP3_ENST00000485192.1_3'UTR	NM_001270507.1|NM_001270508.1|NM_006290.3	NP_001257436.1|NP_001257437.1|NP_006281.1	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	280	TRAF-binding.				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(25)|p.R280fs*1(1)		breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(196)|kidney(1)|large_intestine(4)|lung(13)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	225	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		ACAGAGACCGGGGAAGATTTG	0.358000			"""D, N, F"""		"""marginal zone B-cell lymphomas, Hodgkin's lymphoma, primary mediastinal B cell lymphoma"""								13	47					0	0	0.500413	0	0
NPFFR1	64106	broad.mit.edu	37	10	72026088	72026088	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr10:72026088C>T	ENST00000277942.6	-	2	66	c.67G>A	c.(67-69)Gag>Aag	p.E23K		NM_022146.4	NP_071429.1	Q9GZQ6	NPFF1_HUMAN	neuropeptide FF receptor 1							integral to membrane|plasma membrane	neuropeptide receptor activity			endometrium(2)|lung(1)	3						GGGGTGGCCTCAGTGTTAGTC	0.557000													5	27					0	0	0.184627	0	0
HEATR1	55127	broad.mit.edu	37	1	236716940	236716940	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:236716940A>G	ENST00000366582.3	-	43	6292	c.6178T>C	c.(6178-6180)Tct>Cct	p.S2060P	HEATR1_ENST00000366581.2_Missense_Mutation_p.S1979P	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	2060					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TTCCAAAGAGAGTCATCCGCC	0.493000													16	55					0	0	0.760397	0	0
GPR110	266977	broad.mit.edu	37	6	46969267	46969267	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr6:46969267G>A	ENST00000371253.2	-	14	2845	c.2630C>T	c.(2629-2631)tCa>tTa	p.S877L	GPR110_ENST00000283297.5_Missense_Mutation_p.S680L|GPR110_ENST00000449332.2_5'UTR	NM_153840.2	NP_722582.2	Q5T601	GP110_HUMAN	G protein-coupled receptor 110	877					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	29						GAAAGGCTTTGAGAATTTGGG	0.313000													9	18					0	0	0.387290	0	0
PCDHB15	56121	broad.mit.edu	37	5	140626734	140626734	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr5:140626734C>T	ENST00000231173.3	+	1	1588	c.1588C>T	c.(1588-1590)Cgc>Tgc	p.R530C		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		530	Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTTCGAGTTCCGCGTGGGCGC	0.662000													33	78					0	0	0.750413	0	0
KDM6A	7403	broad.mit.edu	37	X	44870260	44870260	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chrX:44870260C>T	ENST00000377967.4	+	5	480	c.439C>T	c.(439-441)Cag>Tag	p.Q147*	KDM6A_ENST00000382899.4_Nonsense_Mutation_p.Q147*|KDM6A_ENST00000536777.1_Nonsense_Mutation_p.Q147*|KDM6A_ENST00000543216.1_Nonsense_Mutation_p.Q147*	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	147					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0(12)|p.0?(6)|p.?(1)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						TAATGCATTTCAGTGGTAAGT	0.318000			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								10	4					0	0	0.361761	0	0
DNTT	1791	broad.mit.edu	37	10	98078110	98078110	+	Splice_Site	SNP	G	G	A			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr10:98078110G>A	ENST00000419175.1	+	2	375	c.205G>A	c.(205-207)Gat>Aat	p.D69N	DNTT_ENST00000371174.2_Splice_Site_p.D69N	NM_001017520.1|NM_004088.3	NP_001017520.1|NP_004079.3	P04053	TDT_HUMAN	DNA nucleotidylexotransferase	69	BRCT.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	27		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		ATTTTGCAGTGATTCTGTCAC	0.458000													55	83					0	0	0.870114	0	0
NBEA	26960	broad.mit.edu	37	13	36026232	36026232	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr13:36026232C>T	ENST00000540320.1	+	40	6842	c.6308C>T	c.(6307-6309)aCg>aTg	p.T2103M	NBEA_ENST00000379939.2_Missense_Mutation_p.T2100M|NBEA_ENST00000400445.3_Missense_Mutation_p.T2103M|NBEA_ENST00000310336.4_Missense_Mutation_p.T2103M			Q8NFP9	NBEA_HUMAN	neurobeachin	2103						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TGATTAGGCACGGAAGAAGAT	0.308000													9	12					0	0	0.411799	0	0
ARID1A	8289	broad.mit.edu	37	1	27100151	27100152	+	Frame_Shift_Ins	INS	-	-	G			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr1:27100151_27100152insG	ENST00000324856.7	+	16	4318_4319	c.3947_3948insG	c.(3946-3951)tcggggfs	p.SG1316fs	ARID1A_ENST00000540690.1_5'UTR|ARID1A_ENST00000457599.2_Frame_Shift_Ins_p.SG1316fs|ARID1A_ENST00000374152.2_Frame_Shift_Ins_p.SG933fs	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1316					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.M1318fs*163(1)	ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		AACCCAGACTCGGGGATGTATT	0.589			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								28	79	---	---	---	---					
RP11-649A16.1	0	broad.mit.edu	37	3	146995076	146995077	+	RNA	INS	-	-	A			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr3:146995076_146995077insA	ENST00000473299.1	-	0	132																											TTCTGGACTGtaaaaaaaaaaa	0.292													2	4	---	---	---	---					
NAPEPLD	222236	broad.mit.edu	37	7	102760122	102760123	+	Frame_Shift_Ins	INS	-	-	A	rs147416689	by1000genomes	TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr7:102760122_102760123insA	ENST00000417955.1	-	3	996_997	c.842_843insT	c.(841-843)ttcfs	p.F281fs	NAPEPLD_ENST00000465647.1_Frame_Shift_Ins_p.F281fs|NAPEPLD_ENST00000427257.1_Frame_Shift_Ins_p.F281fs|NAPEPLD_ENST00000341533.4_Frame_Shift_Ins_p.F281fs|NAPEPLD_ENST00000455523.2_Frame_Shift_Ins_p.F354fs			Q6IQ20	NAPEP_HUMAN	N-acyl phosphatidylethanolamine phospholipase D	281				Missing (in Ref. 3; CAI56779).	phospholipid catabolic process	membrane	metal ion binding	p.F281fs*14(1)		endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17						TATCTCCTGCGAAAAAAAATCG	0.460													17	56	---	---	---	---					
BEST3	144453	broad.mit.edu	37	12	70091534	70091534	+	Frame_Shift_Del	DEL	A	A	-			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr12:70091534delA	ENST00000330891.5	-	2	271	c.45delT	c.(43-45)tttfs	p.F15fs	BEST3_ENST00000551160.1_Intron|BEST3_ENST00000331471.4_Frame_Shift_Del_p.F15fs|BEST3_ENST00000476098.1_Intron|BEST3_ENST00000266661.4_Intron|BEST3_ENST00000533674.1_Intron|BEST3_ENST00000393365.1_5'UTR|BEST3_ENST00000553096.1_Intron	NM_001282613.1|NM_032735.2	NP_001269542.1|NP_116124.2	Q8N1M1	BEST3_HUMAN	bestrophin 3	15						chloride channel complex|plasma membrane	chloride channel activity			cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	12	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			TATGAAATCCAAAAAAAGTTG	0.353													9	2947	---	---	---	---					
IGHV4OR15-8	28317	broad.mit.edu	37	15	22473268	22473268	+	RNA	DEL	G	G	-			TCGA-G2-A2EK-01A-22D-A18F-08	TCGA-G2-A2EK-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eb73bb35-af99-47b8-8bbb-33b5374e5c74	5f625d04-86a8-48d3-8f6c-4000194a279e	g.chr15:22473268delG	ENST00000557788.2	-	0	46																											ATCAGAGGCAGCCTCCCCTAT	0.582													7	73	---	---	---	---					
