Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ALB	213	broad.mit.edu	37	4	74279157	74279157	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:74279157C>T	ENST00000295897.4	+	8	953	c.864C>T	c.(862-864)atC>atT	p.I288I	ALB_ENST00000503124.1_Silent_p.I138I|ALB_ENST00000415165.2_Silent_p.I96I|ALB_ENST00000509063.1_Silent_p.I288I|ALB_ENST00000505649.1_3'UTR|ALB_ENST00000401494.3_Silent_p.I173I	NM_000477.5	NP_000468.1	P02768	ALBU_HUMAN	albumin	288	Albumin 2.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(6)|liver(9)|lung(16)|ovary(3)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	48	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin iodonated(DB00064)|Serum albumin(DB00096)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	CCAAGTATATCTGTGAAAATC	0.403000													31	44					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152381062	152381062	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:152381062C>G	ENST00000397345.3	-	152	22543	c.22341G>C	c.(22339-22341)aaG>aaC	p.K7447N	NEB_ENST00000409198.1_Missense_Mutation_p.K5746N|NEB_ENST00000604864.1_Missense_Mutation_p.K7447N|NEB_ENST00000603639.1_Missense_Mutation_p.K7447N|NEB_ENST00000172853.10_Missense_Mutation_p.K5746N|NEB_ENST00000427231.2_Missense_Mutation_p.K7447N	NM_001164508.1	NP_001157980	P20929	NEBU_HUMAN	nebulin	5746					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GTGTGGCCTTCTTGATGTCTG	0.498000													73	124					0	0	1	0	0
RGPD8	727851	broad.mit.edu	37	2	113190963	113190963	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:113190963C>G	ENST00000302558.3	-	1	259	c.68G>C	c.(67-69)cGa>cCa	p.R23P	RGPD8_ENST00000409750.1_Intron|RGPD8_ENST00000330575.5_Missense_Mutation_p.R23P	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8											endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						ACTCACCTGTCGAGGCGACGG	0.746000													25	39					0	0	1	0	0
LINS	55180	broad.mit.edu	37	15	101109548	101109548	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:101109548G>C	ENST00000314742.8	-	7	2391	c.2169C>G	c.(2167-2169)atC>atG	p.I723M		NM_001040616.2	NP_001035706	Q8NG48	LINES_HUMAN	lines homolog (Drosophila)	723										central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|prostate(1)|skin(1)|stomach(4)	21						GCAAACGGCAGATGGCATCTT	0.353000													37	70					0	0	1	0	0
IGHV1OR16-3	28313	broad.mit.edu	37	16	32070612	32070612	+	RNA	SNP	A	A	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:32070612A>C	ENST00000566806.1	-	0	499																											GGTCTCCTGCAAGGCTTCTGG	0.552000													3	73					0	0	1	0	0
LMLN	89782	broad.mit.edu	37	3	197701923	197701923	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:197701923G>A	ENST00000330198.4	+	3	350	c.328G>A	c.(328-330)Gag>Aag	p.E110K	LMLN_ENST00000420910.2_Missense_Mutation_p.E110K|LMLN_ENST00000482695.1_Missense_Mutation_p.E58K|LMLN_ENST00000332636.5_Missense_Mutation_p.E58K	NM_033029.3	NP_149018.2	Q96KR4	LMLN_HUMAN	leishmanolysin-like (metallopeptidase M8 family)	110					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		GTTGCTCCCTGAGAAAAAGAA	0.303000													28	69					0	0	1	0	0
C8orf37	157657	broad.mit.edu	37	8	96281381	96281381	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:96281381C>G	ENST00000286688.5	-	1	48	c.37G>C	c.(37-39)Gag>Cag	p.E13Q	KB-1047C11.2_ENST00000521905.1_lincRNA	NM_177965.3	NP_808880.1	Q96NL8	CH037_HUMAN	chromosome 8 open reading frame 37	13										kidney(1)|large_intestine(1)|lung(5)	7	Breast(36;3.41e-05)					AACTTGGACTCGACTTCATCC	0.592000											OREG0018873	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	82	247					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8782742	8782742	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:8782742G>A	ENST00000378641.3	+	32	3938	c.3463G>A	c.(3463-3465)Gag>Aag	p.E1155K	PLCB1_ENST00000378637.2_Missense_Mutation_p.E1155K|PLCB1_ENST00000338037.6_Intron	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	0					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						AACTTGCCATGAGGATCCCTC	0.517000													25	62					0	0	1	0	0
REV3L	5980	broad.mit.edu	37	6	111696872	111696872	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:111696872C>G	ENST00000435970.1	-	15	3268	c.2452G>C	c.(2452-2454)Gac>Cac	p.D818H	REV3L_ENST00000368802.3_Missense_Mutation_p.D896H|REV3L_ENST00000368805.1_Missense_Mutation_p.D896H|REV3L_ENST00000358835.3_Missense_Mutation_p.D896H			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	896					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		AAGTGACAGTCTATAAAACCA	0.368000								DNA polymerases (catalytic subunits)					6	53					0	0	1	0	0
MIR200A	406983	broad.mit.edu	37	1	1103283	1103283	+	RNA	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:1103283C>T	ENST00000384875.1	+	0	41					NR_029834.1																						TGCTGGATTTCCCAGCTTGAC	0.637000													5	7					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8615474	8615474	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:8615474C>T	ENST00000338257.8	-	9	1143	c.876G>A	c.(874-876)ggG>ggA	p.G292G		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	292	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						GGGCGTAATTCCCGTCTTCAC	0.607000													34	75					0	0	1	0	0
SLC13A1	6561	broad.mit.edu	37	7	122769443	122769443	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:122769443G>A	ENST00000194130.2	-	9	1064	c.1025C>T	c.(1024-1026)cCa>cTa	p.P342L	SLC13A1_ENST00000539873.1_3'UTR	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	342						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	TTACCTTATTGGCCCAAGCTT	0.418000													21	27					0	0	1	0	0
LAMC3	10319	broad.mit.edu	37	9	133948634	133948634	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:133948634G>C	ENST00000361069.4	+	20	3553	c.3420G>C	c.(3418-3420)gaG>gaC	p.E1140D	LAMC3_ENST00000480883.1_Intron	NM_006059.3	NP_006050.3	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3	1140	Domain II and I.				cell adhesion	basement membrane|membrane	structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(31)|ovary(3)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	69	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		TTCTACAGGAGATTCCTCAGG	0.577000													15	33					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274087	39274087	+	Missense_Mutation	SNP	G	G	C	rs141357429	by1000genomes	TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:39274087G>C	ENST00000391413.2	-	1	519	c.481C>G	c.(481-483)Ctg>Gtg	p.L161V		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	161	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.L161V(1)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ACTGGACGCAGGcagcagcag	0.657000													3	17					0	0	1	0	0
CIITA	4261	broad.mit.edu	37	16	10996617	10996617	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:10996617C>G	ENST00000324288.8	+	8	864	c.731C>G	c.(730-732)tCt>tGt	p.S244C	CIITA_ENST00000537380.1_3'UTR|CIITA_ENST00000381835.5_Missense_Mutation_p.S195C	NM_000246.3	NP_000237	P33076	C2TA_HUMAN	class II, major histocompatibility complex, transactivator	244					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(7)|ovary(1)|skin(1)|stomach(2)	12						TGGCAAATCTCTGAGGCTGGA	0.592000			T	"""FLJ27352, CD274, CD273, RALGDS, RUNDC2A, C16orf75, BCL6"""	"""PMBL, Hodgkin Lymphona, """								25	46					0	0	1	0	0
SP140	11262	broad.mit.edu	37	2	231110622	231110622	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:231110622G>T	ENST00000392045.3	+	7	823	c.709G>T	c.(709-711)Gaa>Taa	p.E237*	SP140_ENST00000343805.6_Intron|SP140_ENST00000486687.2_Intron|SP140_ENST00000417495.3_Nonsense_Mutation_p.E234*|SP140_ENST00000420434.3_Nonsense_Mutation_p.E237*|SP140_ENST00000350136.5_Nonsense_Mutation_p.E217*	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	237					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AGAATCAGAAGAAATGCCCAA	0.373000													11	52					2.94398e-08	3.09348e-08	1	1	0
REV3L	5980	broad.mit.edu	37	6	111696839	111696839	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:111696839C>G	ENST00000435970.1	-	15	3301	c.2485G>C	c.(2485-2487)Gag>Cag	p.E829Q	REV3L_ENST00000368802.3_Missense_Mutation_p.E907Q|REV3L_ENST00000368805.1_Missense_Mutation_p.E907Q|REV3L_ENST00000358835.3_Missense_Mutation_p.E907Q			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	907					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		AAGGACTGCTCAGTTTCTAAC	0.378000								DNA polymerases (catalytic subunits)					4	57					0	0	1	0	0
VPREB1	7441	broad.mit.edu	37	22	22599468	22599468	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr22:22599468A>T	ENST00000403807.3	+	2	296	c.157A>T	c.(157-159)Agc>Tgc	p.S53C	VPREB1_ENST00000302273.2_Missense_Mutation_p.S52C			P12018	VPREB_HUMAN	pre-B lymphocyte 1	53	Complementarity-determining-1.|Ig-like V-type.				immune response	extracellular region	antigen binding|protein binding			large_intestine(1)|liver(1)|lung(6)|skin(1)	9	all_hematologic(9;0.0312)|Acute lymphoblastic leukemia(84;0.155)	all_cancers(3;3.14e-14)|Acute lymphoblastic leukemia(3;2.97e-57)|all_hematologic(3;5.9e-52)		READ - Rectum adenocarcinoma(21;0.145)		CGGTGTGTACAGCGTCTACTG	0.627000													6	430					0	0	1	0	0
MSH5-SAPCD1	100532732	broad.mit.edu	37	6	31708290	31708290	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:31708290G>A	ENST00000493662.2	+	2	103	c.47G>A	c.(46-48)aGa>aAa	p.R16K	MSH5_ENST00000534153.4_Missense_Mutation_p.R16K|MSH5_ENST00000375755.3_Missense_Mutation_p.R16K|MSH5_ENST00000375703.3_Missense_Mutation_p.R16K|MSH5_ENST00000375750.3_Missense_Mutation_p.R16K|MSH5_ENST00000375742.3_Missense_Mutation_p.R16K|MSH5_ENST00000375740.3_Missense_Mutation_p.R16K|MSH5_ENST00000482280.1_3'UTR																							CAGGGACCGAGACCTGGGGCG	0.677000													3	5					0	0	1	0	0
CLEC4C	170482	broad.mit.edu	37	12	7883463	7883463	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:7883463C>T	ENST00000542353.1	-	6	917	c.427G>A	c.(427-429)Ggg>Agg	p.G143R	CLEC4C_ENST00000354629.5_Missense_Mutation_p.G112R|CLEC4C_ENST00000540085.1_Missense_Mutation_p.G112R|CLEC4C_ENST00000360345.3_Missense_Mutation_p.G143R	NM_130441.2	NP_569708.1	Q8WTT0	CLC4C_HUMAN	C-type lectin domain family 4, member C	143	C-type lectin.				innate immune response	integral to membrane	sugar binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				Kidney(36;0.0915)		TCTGACAGCCCCAGAAAATAA	0.448000													33	76					0	0	1	0	0
GATA5	140628	broad.mit.edu	37	20	61041539	61041539	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:61041539C>T	ENST00000252997.2	-	4	829	c.768G>A	c.(766-768)cgG>cgA	p.R256R		NM_080473.4	NP_536721.1	Q9BWX5	GATA5_HUMAN	GATA binding protein 5	256					blood coagulation|intestinal epithelial cell differentiation|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			kidney(1)|lung(3)|ovary(1)|stomach(1)	6	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;3.08e-06)			CCTCCGAGTTCCGCCGCCACA	0.706000													7	10					0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92471337	92471337	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:92471337G>A	ENST00000267622.4	-	11	3356	c.2983C>T	c.(2983-2985)Caa>Taa	p.Q995*		NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	995					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		TTTGTTTCTTGAAAAATATCA	0.323000			T	PDGFRB	AML								5	24					0	0	1	0	0
CDON	50937	broad.mit.edu	37	11	125859579	125859579	+	Missense_Mutation	SNP	T	T	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:125859579T>G	ENST00000392693.3	-	15	2853	c.2726A>C	c.(2725-2727)gAa>gCa	p.E909A	CDON_ENST00000263577.7_Missense_Mutation_p.E909A|CDON_ENST00000531738.1_Missense_Mutation_p.E286A	NM_001243597.1|NM_016952.4	NP_001230526.1|NP_058648.4	Q4KMG0	CDON_HUMAN	cell adhesion associated, oncogene regulated	909	Fibronectin type-III 3.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(9)|ovary(3)|prostate(2)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	61	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		TTCTCCTCCTTCATTGAAGCA	0.403000													5	110					0	0	1	0	0
WBSCR17	64409	broad.mit.edu	37	7	71130439	71130439	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:71130439G>A	ENST00000333538.5	+	7	1758	c.1124G>A	c.(1123-1125)cGg>cAg	p.R375Q	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	375	Catalytic subdomain B.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				CCTTGCTCACGGGTGGCCCAC	0.517000													5	75					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9916214	9916214	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:9916214C>G	ENST00000396573.2	-	11	2384	c.2075G>C	c.(2074-2076)aGa>aCa	p.R692T	GRIN2A_ENST00000330684.3_Missense_Mutation_p.R692T|GRIN2A_ENST00000535259.1_Missense_Mutation_p.R535T|GRIN2A_ENST00000396575.2_Missense_Mutation_p.R692T|GRIN2A_ENST00000404927.2_Missense_Mutation_p.R692T|GRIN2A_ENST00000562109.1_Missense_Mutation_p.R692T	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	692					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCGAATGTTTCTCTCCGTGCT	0.458000													27	101					0	0	1	0	0
CDH1	999	broad.mit.edu	37	16	68845691	68845691	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:68845691G>A	ENST00000261769.5	+	7	1128	c.937G>A	c.(937-939)Gac>Aac	p.D313N	CDH1_ENST00000422392.2_Missense_Mutation_p.D313N|CDH1_ENST00000562836.1_3'UTR	NM_004360.3	NP_004351.1	P12830	CADH1_HUMAN	cadherin 1, type 1, E-cadherin (epithelial)	313	Cadherin 2.				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding	p.?(1)		NS(6)|biliary_tract(8)|breast(161)|central_nervous_system(4)|endometrium(9)|kidney(4)|large_intestine(13)|lung(13)|oesophagus(3)|ovary(2)|prostate(3)|soft_tissue(2)|stomach(76)|thyroid(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	311		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		TGAGCTCCCTGACAAAAATAT	0.542000			"""Mis, N, F, S"""		"""lobular breast, gastric"""	gastric			Hereditary Diffuse Gastric Cancer				23	37					0	0	1	0	0
ARHGAP12	94134	broad.mit.edu	37	10	32096725	32096725	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:32096725T>C	ENST00000375250.5	-	18	2553	c.2312A>G	c.(2311-2313)tAt>tGt	p.Y771C	ARHGAP12_ENST00000311380.4_Missense_Mutation_p.Y749C|ARHGAP12_ENST00000344936.2_Missense_Mutation_p.Y801C|ARHGAP12_ENST00000375245.4_Missense_Mutation_p.Y749C|ARHGAP12_ENST00000492028.1_5'UTR|ARHGAP12_ENST00000396144.4_Missense_Mutation_p.Y796C	NM_001270696.1|NM_001270698.1	NP_001257625.1|NP_001257627.1	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	801	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(11)|lung(10)|skin(1)|urinary_tract(2)	31		Prostate(175;0.0199)				TATACTCTGATAGGTCATTCG	0.328000													12	30					0	0	1	0	0
SCAPER	49855	broad.mit.edu	37	15	76797229	76797229	+	Silent	SNP	A	A	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:76797229A>G	ENST00000538941.2	-	24	3126	c.2187T>C	c.(2185-2187)aaT>aaC	p.N729N	SCAPER_ENST00000324767.7_Silent_p.N975N|SCAPER_ENST00000563290.1_Silent_p.N975N	NM_001145923.1	NP_001139395.1	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	974	Glu-rich.					endoplasmic reticulum|nucleus	zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(16)|ovary(2)|prostate(2)|skin(1)|urinary_tract(2)	39						CTGTGTTCACATTTGTGGCTG	0.383000													13	23					0	0	1	0	0
UBR2	23304	broad.mit.edu	37	6	42626436	42626436	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:42626436G>A	ENST00000372899.1	+	29	3374	c.3116G>A	c.(3115-3117)aGa>aAa	p.R1039K	UBR2_ENST00000372883.3_Missense_Mutation_p.D547N|UBR2_ENST00000372901.1_Missense_Mutation_p.R1039K	NM_015255.2	NP_056070.1	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin 2	1039					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(7)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|skin(5)	64	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			GAGATTGCCAGACTGCGCAGA	0.408000													15	42					0	0	1	0	0
GRAMD1B	57476	broad.mit.edu	37	11	123448178	123448178	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:123448178G>C	ENST00000529750.1	+	2	454	c.127G>C	c.(127-129)Gag>Cag	p.E43Q	GRAMD1B_ENST00000456860.2_Missense_Mutation_p.E43Q|GRAMD1B_ENST00000322282.7_Missense_Mutation_p.E43Q	NM_020716.1	NP_065767.1	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	43						integral to membrane				NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		CACCATGGTGGAGAAGGGCTC	0.677000											OREG0021454	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	6					0	0	1	0	0
TBX3	6926	broad.mit.edu	37	12	115118866	115118866	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:115118866C>G	ENST00000349155.2	-	2	1438	c.475G>C	c.(475-477)Gat>Cat	p.D159H	TBX3_ENST00000257566.3_Missense_Mutation_p.D159H	NM_005996.3	NP_005987.3	O15119	TBX3_HUMAN	T-box 3	159					anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			breast(5)|endometrium(1)|kidney(1)|large_intestine(6)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		CGACAGTCATCAGCAGCTATA	0.438000													32	92					0	0	1	0	0
ARRDC3	57561	broad.mit.edu	37	5	90678672	90678672	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:90678672C>G	ENST00000265138.3	-	1	504	c.238G>C	c.(238-240)Gag>Cag	p.E80Q		NM_020801.2	NP_065852.1	Q96B67	ARRD3_HUMAN	arrestin domain containing 3	80					signal transduction	cytoplasm	protein binding			breast(2)|endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|urinary_tract(1)	18		all_cancers(142;2.22e-05)|all_epithelial(76;1.58e-07)|all_lung(232;0.000521)|Lung NSC(167;0.000548)|Ovarian(174;0.0798)|Colorectal(57;0.207)		OV - Ovarian serous cystadenocarcinoma(54;4.56e-30)|Epithelial(54;7.55e-26)|all cancers(79;3.63e-22)		TTGAAATACTCTACTTCTTCA	0.378000													44	40					0	0	1	0	0
KIAA0195	9772	broad.mit.edu	37	17	73488566	73488566	+	Silent	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:73488566G>C	ENST00000314256.7	+	15	2002	c.1608G>C	c.(1606-1608)ggG>ggC	p.G536G	KIAA0195_ENST00000375248.5_Silent_p.G546G|KIAA0195_ENST00000579208.1_Silent_p.G187G	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	536					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCCAGCCTGGGATGGAGAGCG	0.632000													5	37					0	0	1	0	0
NRG1	3084	broad.mit.edu	37	8	32621582	32621582	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:32621582C>A	ENST00000338921.4	+	13	2126	c.1609C>A	c.(1609-1611)Caa>Aaa	p.Q537K	NRG1_ENST00000287842.3_Missense_Mutation_p.Q526K|NRG1_ENST00000405005.3_Missense_Mutation_p.Q529K|NRG1_ENST00000341377.5_3'UTR|NRG1_ENST00000356819.4_Missense_Mutation_p.Q534K|NRG1_ENST00000519301.1_Missense_Mutation_p.Q479K|NRG1_ENST00000287845.5_Missense_Mutation_p.Q500K|NRG1_ENST00000539990.1_Missense_Mutation_p.Q372K			Q02297	NRG1_HUMAN	neuregulin 1	529					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(1)|skin(1)	39		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		TGAAACGACCCAAGAGTACGA	0.542000													11	21					3.07112e-06	3.17743e-06	1	1	0
ETF1	2107	broad.mit.edu	37	5	137846256	137846256	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:137846256C>G	ENST00000499810.2	-	9	1430	c.982G>C	c.(982-984)Gag>Cag	p.E328Q	ETF1_ENST00000503014.1_Missense_Mutation_p.E347Q|ETF1_ENST00000360541.5_Missense_Mutation_p.E361Q	NM_001256302.1|NM_001282185.1	NP_001243231.1|NP_001269114.1	P62495	ERF1_HUMAN	eukaryotic translation termination factor 1	361					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein methylation|regulation of translational termination	cytoplasm	protein binding|ribosome binding|translation release factor activity, codon specific	p.E361Q(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)|urinary_tract(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TCACATACCTCTTTGTCTGTG	0.398000													6	40					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90124959	90124959	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:90124959G>T	ENST00000405460.2	+	77	16663	c.16567G>T	c.(16567-16569)Gat>Tat	p.D5523Y	GPR98_ENST00000425867.2_Missense_Mutation_p.D1184Y	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	5523					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GGTGGCCAGAGATTCTGGGAC	0.418000													75	53					5.10314e-47	5.64916e-47	1	1	0
OR52I2	143502	broad.mit.edu	37	11	4608387	4608387	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:4608387C>T	ENST00000312614.4	+	1	367	c.345C>T	c.(343-345)ttC>ttT	p.F115F		NM_001005170.2	NP_001005170.1	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I, member 2	115					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|pancreas(1)|skin(1)	19		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGAGCATCTTCTGCTCAGGAG	0.512000													61	75					0	0	1	0	0
ZNF473	25888	broad.mit.edu	37	19	50548458	50548458	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:50548458C>T	ENST00000595661.1	+	6	1253	c.758C>T	c.(757-759)tCt>tTt	p.S253F	ZNF473_ENST00000601364.1_Intron|ZNF473_ENST00000391821.2_Missense_Mutation_p.S253F|ZNF473_ENST00000270617.3_Missense_Mutation_p.S253F|ZNF473_ENST00000445728.3_Missense_Mutation_p.S241F|CTD-2126E3.3_ENST00000599410.1_RNA|CTD-2126E3.3_ENST00000599914.1_RNA			Q8WTR7	ZN473_HUMAN	zinc finger protein 473	253					histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(9)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	37		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		GCTTCCCTTTCTGTGTATCCG	0.453000													43	223					0	0	1	0	0
MFSD7	84179	broad.mit.edu	37	4	675782	675782	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:675782G>A	ENST00000322224.4	-	10	1958	c.1645C>T	c.(1645-1647)Cac>Tac	p.H549Y	MYL5_ENST00000400159.2_Silent_p.*174*|MYL5_ENST00000511290.1_Silent_p.*133*|MFSD7_ENST00000404286.2_Missense_Mutation_p.H550Y|MYL5_ENST00000506838.1_Silent_p.*133*|MYL5_ENST00000505477.1_Silent_p.*133*|MFSD7_ENST00000503156.1_3'UTR|MFSD7_ENST00000515118.1_Missense_Mutation_p.H453Y|MFSD7_ENST00000347950.5_Missense_Mutation_p.H431Y			Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing 7	550					transmembrane transport	integral to membrane				cervix(1)|kidney(2)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	11						AAGGAGGAGTGAGACCCAGCC	0.657000													5	24					0	0	1	0	0
TSPEAR	54084	broad.mit.edu	37	21	45948467	45948467	+	Splice_Site	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:45948467C>G	ENST00000323084.4	-	6	856		c.e6-1		TSPEAR_ENST00000397916.1_Splice_Site	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats						cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						ATGTTGGTTTCTGAGGGGAAG	0.597000													15	15					0	0	1	0	0
VASH1	22846	broad.mit.edu	37	14	77242469	77242469	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:77242469G>A	ENST00000167106.4	+	5	1398	c.765G>A	c.(763-765)aaG>aaA	p.K255K	VASH1_ENST00000556038.1_3'UTR|RP11-488C13.6_ENST00000556368.1_RNA	NM_014909.4	NP_055724.1	Q7L8A9	VASH1_HUMAN	vasohibin 1	255					cell cycle arrest|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of endothelial cell proliferation	endoplasmic reticulum|extracellular space				breast(2)|endometrium(1)|large_intestine(1)|lung(1)|prostate(1)|stomach(1)|urinary_tract(3)	10			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0283)		ACGTGCTCAAGAAGGTGAAGC	0.677000													5	13					0	0	1	0	0
MRPL33	9553	broad.mit.edu	37	2	27997305	27997305	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:27997305G>C	ENST00000296102.3	+	3	117	c.56G>C	c.(55-57)aGa>aCa	p.R19T	MRPL33_ENST00000379666.3_Intron|MRPL33_ENST00000483992.1_Intron	NM_004891.3	NP_004882.1	O75394	RM33_HUMAN	mitochondrial ribosomal protein L33	19					translation	mitochondrion|ribosome	structural constituent of ribosome			breast(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(172;0.155)					ATTCTGGTGAGAATGGTGAGC	0.423000													51	99					0	0	1	0	0
SCAF1	58506	broad.mit.edu	37	19	50155777	50155777	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:50155777G>A	ENST00000360565.3	+	7	2255	c.2131G>A	c.(2131-2133)Gac>Aac	p.D711N		NM_021228.2	NP_067051.2	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	711	Ser-rich.				mRNA processing|RNA splicing	nucleus	RNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	20		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		GGGCCGGCTTGACAAGTCCGA	0.711000													15	10					0	0	1	0	0
TPD52	7163	broad.mit.edu	37	8	80992661	80992661	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:80992661C>A	ENST00000520527.1	-	1	390	c.28G>T	c.(28-30)Gag>Tag	p.E10*	TPD52_ENST00000518937.1_Intron|TPD52_ENST00000379097.3_Nonsense_Mutation_p.E10*|TPD52_ENST00000517427.1_Nonsense_Mutation_p.E10*|TPD52_ENST00000379096.5_Intron|TPD52_ENST00000519303.2_Intron|TPD52_ENST00000537855.1_Nonsense_Mutation_p.E10*|TPD52_ENST00000448733.2_Nonsense_Mutation_p.E10*			P55327	TPD52_HUMAN	tumor protein D52	10					anatomical structure morphogenesis|B cell differentiation|secretion	endoplasmic reticulum|perinuclear region of cytoplasm	calcium ion binding|protein heterodimerization activity|protein homodimerization activity			endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	8	all_epithelial(4;1.13e-09)|Lung NSC(7;9.71e-07)|all_lung(9;3.75e-06)	Lung NSC(129;3.55e-06)|all_lung(136;1.53e-05)|Acute lymphoblastic leukemia(644;0.158)	BRCA - Breast invasive adenocarcinoma(6;0.00181)|Epithelial(68;0.0149)|all cancers(69;0.0612)			TGGTAGTCCTCATATAAGTCC	0.463000													19	38					1.55469e-16	1.67957e-16	1	1	0
COL6A6	131873	broad.mit.edu	37	3	130282479	130282479	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:130282479A>G	ENST00000358511.6	+	2	663	c.632A>G	c.(631-633)gAg>gGg	p.E211G	COL6A6_ENST00000453409.2_Missense_Mutation_p.E211G	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	211	Nonhelical region.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						AAGTACAAGGAGGGAGCAGTT	0.403000													4	59					0	0	1	0	0
ACTRT2	140625	broad.mit.edu	37	1	2938571	2938571	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:2938571G>A	ENST00000378404.2	+	1	526	c.321G>A	c.(319-321)ctG>ctA	p.L107L		NM_080431.4	NP_536356.3	Q8TDY3	ACTT2_HUMAN	actin-related protein T2	107						cytoplasm|cytoskeleton				breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		ACCAGCCCCTGCTTGCAACGG	0.597000													31	49					0	0	1	0	0
KIAA1244	57221	broad.mit.edu	37	6	138655797	138655797	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:138655797C>A	ENST00000251691.4	+	33	5980	c.5814C>A	c.(5812-5814)ttC>ttA	p.F1938L		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	1938					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		ACCCGTTCTTCATCCTGCCCT	0.572000													7	36					5.16669e-11	5.51523e-11	1	1	0
GHSR	2693	broad.mit.edu	37	3	172165775	172165775	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:172165775G>A	ENST00000241256.2	-	1	471	c.429C>T	c.(427-429)ttC>ttT	p.F143F	GHSR_ENST00000427970.1_Silent_p.F143F	NM_198407.2	NP_940799.1	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor	143					actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	33	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			AGCAGATGGCGAAGTAGCGCT	0.627000													10	29					0	0	1	0	0
SCUBE3	222663	broad.mit.edu	37	6	35213161	35213161	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:35213161C>A	ENST00000274938.7	+	19	2558	c.2558C>A	c.(2557-2559)tCt>tAt	p.S853Y	SCUBE3_ENST00000394681.1_Missense_Mutation_p.S869Y	NM_152753.2	NP_689966.2	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	853	CUB.				protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(12)|lung(11)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	37						TTCCTGCCATCTGAGGATGAG	0.567000													19	61					3.6726e-16	3.94383e-16	1	1	0
MOCS3	27304	broad.mit.edu	37	20	49576335	49576335	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:49576335C>A	ENST00000244051.1	+	1	973	c.956C>A	c.(955-957)tCa>tAa	p.S319*		NM_014484.3	NP_055299.1	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	319					enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	24						TGTGGCTCCTCAGCCACTGAT	0.587000													19	63					2.89027e-11	3.09138e-11	1	1	0
IKBKB	3551	broad.mit.edu	37	8	42176072	42176072	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:42176072C>G	ENST00000520810.1	+	13	1429	c.1243C>G	c.(1243-1245)Caa>Gaa	p.Q415E	IKBKB_ENST00000520835.1_Missense_Mutation_p.Q413E|IKBKB_ENST00000416505.2_Missense_Mutation_p.Q356E|IKBKB_ENST00000522147.1_Intron|IKBKB_ENST00000379708.3_Missense_Mutation_p.Q192E	NM_001556.2	NP_001547.1	O14920	IKKB_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	415					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(4)|lung(1)|ovary(2)|skin(1)	8	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	GTCTCCAGTTCAAGAGCCCAA	0.498000													47	92					0	0	1	0	0
CUBNP3	100421634	broad.mit.edu	37	10	45642902	45642902	+	RNA	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:45642902C>G	ENST00000427229.2	+	0	61																											AGGTTAAACTCTTTTTCCAAC	0.413000													11	30					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142609893	142609893	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:142609893C>G	ENST00000265310.1	-	13	1891	c.1543G>C	c.(1543-1545)Gag>Cag	p.E515Q		NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	515					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					GTTGGGTCCTCTGTCTGGAAA	0.468000													35	71					0	0	1	0	0
GSX2	170825	broad.mit.edu	37	4	54968002	54968002	+	Silent	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:54968002G>C	ENST00000326902.2	+	2	1142	c.828G>C	c.(826-828)ggG>ggC	p.G276G	GSX2_ENST00000548609.1_3'UTR|FIP1L1_ENST00000507166.1_Intron|GSX2_ENST00000503800.1_3'UTR	NM_133267.2	NP_573574.1	Q9BZM3	GSX2_HUMAN	GS homeobox 2	276						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(2)|lung(2)	6	all_cancers(7;0.00671)|Lung NSC(11;0.0154)|all_neural(26;0.0209)|Glioma(25;0.08)|all_epithelial(27;0.147)		LUSC - Lung squamous cell carcinoma(32;0.00216)			AGTGCGTCGGGAGCCAGGTGC	0.607000													10	25					0	0	1	0	0
SYNGAP1	8831	broad.mit.edu	37	6	33393617	33393617	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:33393617C>G	ENST00000418600.2	+	3	333	c.232C>G	c.(232-234)Cgc>Ggc	p.R78G	SYNGAP1_ENST00000293748.5_Missense_Mutation_p.R78G|SYNGAP1_ENST00000496374.1_3'UTR	NM_006772.2	NP_006763.2	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	78					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(15)|ovary(7)|pancreas(1)|stomach(1)|urinary_tract(1)	43						CGAGTCCAGTCGCAACAAACT	0.692000													34	52					0	0	1	0	0
MEX3A	92312	broad.mit.edu	37	1	156046708	156046708	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:156046708G>C	ENST00000532414.2	-	2	1219	c.1220C>G	c.(1219-1221)tCt>tGt	p.S407C		NM_001093725.1	NP_001087194.1	A1L020	MEX3A_HUMAN	mex-3 RNA binding family member A	407	Poly-Ser.					cytoplasmic mRNA processing body|nucleus	RNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)	9	Hepatocellular(266;0.158)|all_neural(408;0.195)					ggaggaggcagaggagaagAG	0.726000													4	5					0	0	1	0	0
OR2W1	26692	broad.mit.edu	37	6	29012734	29012734	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:29012734G>C	ENST00000377175.1	-	1	283	c.219C>G	c.(217-219)ttC>ttG	p.F73L		NM_030903.3	NP_112165.1	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W, member 1	73					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|skin(1)	23						TGCTGGTTGTGAAACATAGAT	0.428000													4	63					0	0	1	0	0
KDM7A	80853	broad.mit.edu	37	7	139799789	139799789	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:139799789T>C	ENST00000397560.2	-	13	1770	c.1673A>G	c.(1672-1674)aAc>aGc	p.N558S	JHDM1D_ENST00000006967.5_Missense_Mutation_p.N558S	NM_030647.1	NP_085150.1	Q6ZMT4	KDM7_HUMAN		558					midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|stomach(1)	22	Melanoma(164;0.0142)					GAGATGTTTGTTGAATTTTCC	0.398000													44	83					0	0	1	0	0
CNTNAP3	79937	broad.mit.edu	37	9	39178358	39178358	+	Splice_Site	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:39178358C>G	ENST00000297668.6	-	5	612		c.e5-1		CNTNAP3_ENST00000358144.2_Splice_Site|CNTNAP3_ENST00000377653.2_Splice_Site|CNTNAP3_ENST00000377656.2_Splice_Site|CNTNAP3_ENST00000323947.7_Splice_Site|CNTNAP3_ENST00000377659.1_Splice_Site	NM_033655.3	NP_387504.2	Q9BZ76	CNTP3_HUMAN	contactin associated protein-like 3						cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	24				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		ACCTCAGATTCTAGGAAAGAA	0.313000													32	34					0	0	1	0	0
CCDC83	220047	broad.mit.edu	37	11	85630484	85630484	+	Silent	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:85630484C>G	ENST00000280245.4	+	12	1778	c.1266C>G	c.(1264-1266)gtC>gtG	p.V422V	CCDC83_ENST00000376067.1_Silent_p.V291V|RP11-90K17.2_ENST00000531414.1_RNA|CCDC83_ENST00000342404.3_Silent_p.V391V	NM_173556.3	NP_775827.2	Q8IWF9	CCD83_HUMAN	coiled-coil domain containing 83	391										breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(12)|skin(3)|upper_aerodigestive_tract(2)	29		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				AAATTCCAGTCAAACTCTATA	0.413000													16	39					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80771649	80771649	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:80771649G>C	ENST00000458043.2	+	58	6862	c.6856G>C	c.(6856-6858)Ggc>Cgc	p.G2286R	OTOGL_ENST00000547103.1_Missense_Mutation_p.G2274R|OTOGL_ENST00000546620.1_Missense_Mutation_p.G305R	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						ATCTTGTGACGGCAAATGCCC	0.343000													6	14					0	0	1	0	0
ZNF282	8427	broad.mit.edu	37	7	148921658	148921658	+	Silent	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:148921658C>G	ENST00000262085.3	+	8	2040	c.1935C>G	c.(1933-1935)ctC>ctG	p.L645L	ZNF282_ENST00000479907.1_3'UTR	NM_003575.2	NP_003566.1	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	645					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(3)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	17	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		AGGAGTCGCTCAAGGACCACC	0.721000													6	7					0	0	1	0	0
IGHV1-18	28468	broad.mit.edu	37	14	106641745	106641745	+	RNA	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:106641745G>A	ENST00000390605.2	-	0	227																											GGGGCCTGTCGCACCCAGCTG	0.552000													22	431					0	0	1	0	0
SH3BP5	9467	broad.mit.edu	37	3	15297659	15297659	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:15297659G>A	ENST00000383791.3	-	9	1522	c.1302C>T	c.(1300-1302)ctC>ctT	p.L434L	SH3BP5-AS1_ENST00000420195.1_RNA|SH3BP5_ENST00000426925.1_Silent_p.L277L|SH3BP5_ENST00000408919.3_Silent_p.L277L|SH3BP5_ENST00000253688.5_Silent_p.L277L	NM_004844.4	NP_004835.2	O60239	3BP5_HUMAN	SH3-domain binding protein 5 (BTK-associated)	434					intracellular signal transduction	mitochondrion	protein kinase inhibitor activity|SH3 domain binding			NS(1)|endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	12						ACTGTAGGGAGAGCTGCTTCA	0.552000													170	150					0	0	1	0	0
PYGM	5837	broad.mit.edu	37	11	64514251	64514251	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:64514251G>A	ENST00000164139.3	-	20	2807	c.2409C>T	c.(2407-2409)atC>atT	p.I803I	PYGM_ENST00000377432.3_Silent_p.I715I	NM_005609.2	NP_005600.1	P11217	PYGM_HUMAN	phosphorylase, glycogen, muscle	803					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					Pyridoxal Phosphate(DB00114)	CTATGTTCCGGATCACCATCC	0.607000													41	58					0	0	1	0	0
ACPT	93650	broad.mit.edu	37	19	51295390	51295390	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:51295390G>A	ENST00000270593.1	+	5	511	c.511G>A	c.(511-513)Gag>Aag	p.E171K	ACPT_ENST00000270594.3_Intron	NM_033068.2	NP_149059.1	Q9BZG2	PPAT_HUMAN	acid phosphatase, testicular	171						integral to membrane	acid phosphatase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|skin(3)	11		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		GGAGGCCACCGAGGCCGCCGA	0.706000													6	6					0	0	1	0	0
SLC22A2	6582	broad.mit.edu	37	6	160664743	160664743	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:160664743G>A	ENST00000366953.3	-	7	1398	c.1140C>T	c.(1138-1140)ttC>ttT	p.F380F	SLC22A2_ENST00000491092.1_5'UTR	NM_003058.3	NP_003049.2	O15244	S22A2_HUMAN	solute carrier family 22 (organic cation transporter), member 2	380					body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(16)|prostate(2)|skin(1)	27		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		CAGAGTAGAAGAAATCCAGGT	0.527000													19	52					0	0	1	0	0
RP11-252A24.2	0	broad.mit.edu	37	16	74394786	74394786	+	RNA	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:74394786C>G	ENST00000429810.2	-	0	179																											CTCAGGAACTCAAACTAGACA	0.438000													5	9					0	0	1	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20874807	20874807	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:20874807G>T	ENST00000381552.1	+	8	1213	c.845G>T	c.(844-846)gGa>gTa	p.G282V	SLCO1C1_ENST00000540354.1_Missense_Mutation_p.G233V|SLCO1C1_ENST00000545604.1_Missense_Mutation_p.G282V|SLCO1C1_ENST00000266509.2_Missense_Mutation_p.G282V|SLCO1C1_ENST00000545102.1_Missense_Mutation_p.G164V			Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1	282					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					CTAATAGCAGGAATCATAAGT	0.438000													19	31					8.34094e-07	8.69656e-07	1	1	0
SNIP1	79753	broad.mit.edu	37	1	38003556	38003556	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:38003556G>A	ENST00000296215.6	-	4	1056	c.984C>T	c.(982-984)atC>atT	p.I328I		NM_024700.3	NP_078976.2	Q8TAD8	SNIP1_HUMAN	Smad nuclear interacting protein 1	328	FHA.				production of miRNAs involved in gene silencing by miRNA	nucleus	protein binding			breast(2)|cervix(2)|endometrium(1)|large_intestine(3)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	25		Myeloproliferative disorder(586;0.0393)				CAAGGTCAATGATGTAGGGCT	0.433000													30	52					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108236083	108236083	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:108236083G>A	ENST00000278616.4	+	63	9404	c.9019G>A	c.(9019-9021)Gaa>Aaa	p.E3007K	C11orf65_ENST00000526725.1_Intron|ATM_ENST00000525178.1_3'UTR|ATM_ENST00000452508.2_Missense_Mutation_p.E3007K|C11orf65_ENST00000525729.1_Intron	NM_000051.3	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	3007					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		CAAAGTAGCTGAACGTGTCTT	0.413000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			17	65					0	0	1	0	0
FKBP15	23307	broad.mit.edu	37	9	115959352	115959352	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:115959352C>T	ENST00000238256.3	-	9	841	c.724G>A	c.(724-726)Gag>Aag	p.E242K		NM_015258.1	NP_056073.1	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	242	PPIase FKBP-type.				endocytosis|protein folding	axon|early endosome	actin binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(9)|ovary(3)|urinary_tract(1)	26						ATTCCATCCTCCCAGCCCTTT	0.463000													27	89					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34059676	34059676	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:34059676C>T	ENST00000538487.2	-	3	1163	c.720G>A	c.(718-720)caG>caA	p.Q240Q	GRM4_ENST00000374181.4_Silent_p.Q240Q|GRM4_ENST00000455714.2_Silent_p.Q100Q|GRM4_ENST00000374177.3_Silent_p.Q171Q|GRM4_ENST00000535756.1_Silent_p.Q107Q|GRM4_ENST00000609222.1_Silent_p.Q107Q|GRM4_ENST00000544773.2_Silent_p.Q71Q	NM_000841.2|NM_001256811.1	NP_000832.1|NP_001243740.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4						activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	CACGGGACTTCTGGATGAAGG	0.637000													4	24					0	0	1	0	0
JADE3	9767	broad.mit.edu	37	X	46913959	46913959	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chrX:46913959G>C	ENST00000218343.4	+	9	1670	c.1372G>C	c.(1372-1374)Gtg>Ctg	p.V458L	PHF16_ENST00000397189.1_Missense_Mutation_p.V458L	NM_014735.3	NP_055550.1	Q92613	JADE3_HUMAN		458					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(2)	33						AAATGGGCTGGTGCAGCCAAA	0.433000													11	6					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123657408	123657408	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chrX:123657408C>G	ENST00000422452.2	-	17	2902	c.2839G>C	c.(2839-2841)Gag>Cag	p.E947Q	TENM1_ENST00000371130.3_Missense_Mutation_p.E947Q	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		GTTCTCTTCTCAGGCAGGAAA	0.468000													39	5					0	0	1	0	0
ZNF394	84124	broad.mit.edu	37	7	99097298	99097298	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:99097298C>T	ENST00000337673.6	-	1	622	c.419G>A	c.(418-420)cGg>cAg	p.R140Q	ZNF394_ENST00000394177.3_5'UTR|ZNF789_ENST00000494186.1_Intron|ZNF789_ENST00000493485.1_Intron|ZNF394_ENST00000426306.2_Missense_Mutation_p.R140Q	NM_032164.2	NP_115540.2	Q53GI3	ZN394_HUMAN	zinc finger protein 394	140	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(5)|stomach(1)|urinary_tract(1)	16	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					CTGCAGAGCCCGCACCACGGC	0.632000													38	99					0	0	1	0	0
PDXDC2P	283970	broad.mit.edu	37	16	70010650	70010650	+	RNA	SNP	A	A	G	rs144900726	by1000genomes	TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:70010650A>G	ENST00000531894.1	-	0	3748					NR_003610.1																						AGGGCCGAAGAAGGGAATGTT	0.468000													3	77					0	0	1	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45567023	45567023	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr18:45567023C>G	ENST00000588982.1	-	3	957	c.456G>C	c.(454-456)gaG>gaC	p.E152D	ZBTB7C_ENST00000535628.2_Missense_Mutation_p.E152D|ZBTB7C_ENST00000332053.2_Missense_Mutation_p.E152D|ZBTB7C_ENST00000586438.1_Missense_Mutation_p.E152D|ZBTB7C_ENST00000590800.1_Missense_Mutation_p.E152D			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	152	Asp-rich.|Glu-rich.					intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						cctcttcgtcctcctcatcat	0.577000													5	17					0	0	1	0	0
SCAF4	57466	broad.mit.edu	37	21	33069064	33069064	+	Splice_Site	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:33069064C>T	ENST00000286835.7	-	8	1160		c.e8-1		SCAF4_ENST00000399804.1_Splice_Site|SCAF4_ENST00000434667.3_Splice_Site	NM_020706.2	NP_065757.1	O95104	SFR15_HUMAN	SR-related CTD-associated factor 4							nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(11)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						CAAGCAACTTCTGGAATAATT	0.388000													23	50					0	0	1	0	0
FAM208B	54906	broad.mit.edu	37	10	5798582	5798582	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:5798582C>T	ENST00000328090.5	+	16	7238	c.6613C>T	c.(6613-6615)Ctg>Ttg	p.L2205L		NM_017782.4	NP_060252	Q5VWN6	CJ018_HUMAN	family with sequence similarity 208, member B	2205																	TCAGAACCTTCTGAGGAAAGG	0.338000													17	36					0	0	1	0	0
SMARCA2	6595	broad.mit.edu	37	9	2110327	2110327	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:2110327C>G	ENST00000382203.1	+	24	3575	c.3366C>G	c.(3364-3366)ttC>ttG	p.F1122L	SMARCA2_ENST00000357248.2_Missense_Mutation_p.F1122L|SMARCA2_ENST00000382194.1_Missense_Mutation_p.F1122L|SMARCA2_ENST00000349721.2_Missense_Mutation_p.F1122L			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	1122	Helicase C-terminal.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		ATTTCATTTTCTTGCTGAGCA	0.463000													30	41					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22663086	22663086	+	RNA	SNP	T	T	G	rs1054157	by1000genomes	TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr22:22663086T>G	ENST00000426066.1	+	0	525					NR_027293.1																						AGCTGCCACATAAGTTGTCCT	0.299000													11	46					0	0	1	0	0
IGHG4	3503	broad.mit.edu	37	14	106091086	106091086	+	RNA	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:106091086C>G	ENST00000390543.2	-	0	710																											TCTTGGTCATCTCCTCCTGGG	0.637000													39	374					0	0	1	0	0
RET	5979	broad.mit.edu	37	10	43619223	43619223	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:43619223G>A	ENST00000355710.3	+	17	3138	c.2906G>A	c.(2905-2907)cGg>cAg	p.R969Q	RET_ENST00000340058.5_Missense_Mutation_p.R969Q	NM_020975.4	NP_066124.1	P07949	RET_HUMAN	ret proto-oncogene	969	Protein kinase.				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity		CCDC6/RET(4)|KIF5B/RET(79)	NS(2)|adrenal_gland(26)|breast(5)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|lung(27)|ovary(5)|prostate(3)|skin(1)|thyroid(504)|upper_aerodigestive_tract(1)|urinary_tract(1)	607		Ovarian(717;0.0423)			Sunitinib(DB01268)	ACCGGCCACCGGATGGAGAGG	0.597000		1	"""T, Mis, N, F"""	"""H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3, KIF5B, CCDC6"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma, NSCLC"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma"""	Hirschsprung disease		Multiple Endocrine Neoplasia, type 2B;Multiple Endocrine Neoplasia, type 2A;Familial Medullary Thyroid Carcinoma				3	84					0	0	1	0	0
RIMS4	140730	broad.mit.edu	37	20	43385652	43385652	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:43385652C>G	ENST00000372851.3	-	5	544	c.478G>C	c.(478-480)Gag>Cag	p.E160Q	RIMS4_ENST00000541604.2_Missense_Mutation_p.E161Q	NM_001205317.1|NM_182970.3	NP_001192246.1|NP_892015.1	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	160	C2.				exocytosis|neurotransmitter transport	cell junction|synapse				central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(11)|ovary(5)|urinary_tract(1)	29		Myeloproliferative disorder(115;0.0122)				ATGCCATTCTCTAGCAGGTAG	0.562000													93	205					0	0	1	0	0
DMTF1	9988	broad.mit.edu	37	7	86794344	86794344	+	Silent	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:86794344C>A	ENST00000394703.5	+	5	650	c.87C>A	c.(85-87)ctC>ctA	p.L29L	DMTF1_ENST00000331242.7_Silent_p.L29L|DMTF1_ENST00000411766.2_Silent_p.L29L|DMTF1_ENST00000432937.2_Intron|DMTF1_ENST00000394702.3_Silent_p.L29L|DMTF1_ENST00000413276.2_Silent_p.L29L|DMTF1_ENST00000414194.2_5'UTR	NM_021145.3	NP_066968.3	Q9Y222	DMTF1_HUMAN	cyclin D binding myb-like transcription factor 1	29	Interaction with CCND2 (By similarity).				cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)	16	Esophageal squamous(14;0.0058)					AAGGGAATCTCATTCTTCACT	0.418000													15	49					5.35267e-07	5.59172e-07	1	1	0
XIRP1	165904	broad.mit.edu	37	3	39228623	39228623	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:39228623C>T	ENST00000340369.3	-	2	2542	c.2314G>A	c.(2314-2316)Gag>Aag	p.E772K	XIRP1_ENST00000396251.1_Missense_Mutation_p.E772K|XIRP1_ENST00000421646.1_Intron	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	772							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		AGGGTCCCCTCAGCTGCAGTC	0.632000													27	35					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79324197	79324197	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:79324197G>C	ENST00000428286.1	-	8	3116	c.1916C>G	c.(1915-1917)tCa>tGa	p.S639*	PRUNE2_ENST00000376718.3_Nonsense_Mutation_p.S998*			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	998					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						ACCATCTTTTGACTCAAAACC	0.453000													14	13					0	0	1	0	0
CTNNA1	1495	broad.mit.edu	37	5	138269620	138269620	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:138269620C>G	ENST00000302763.7	+	18	2653	c.2563C>G	c.(2563-2565)Cct>Gct	p.P855A	CTNNA1_ENST00000540387.1_Missense_Mutation_p.P485A|CTNNA1_ENST00000355078.5_Missense_Mutation_p.P752A|CTNNA1_ENST00000518825.1_3'UTR	NM_001903.2	NP_001894.2	P35221	CTNA1_HUMAN	catenin (cadherin-associated protein), alpha 1, 102kDa	855					adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			NS(1)|breast(7)|cervix(2)|endometrium(4)|kidney(6)|large_intestine(16)|lung(9)|oesophagus(2)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	52			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			CCTCAACCTTCCTGCTGTGTC	0.478000													3	39					0	0	1	0	0
C6orf106	64771	broad.mit.edu	37	6	34664291	34664291	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:34664291C>T	ENST00000374023.3	-	1	333	c.90G>A	c.(88-90)gaG>gaA	p.E30E	C6orf106_ENST00000374026.3_Silent_p.E30E|RP11-140K17.3_ENST00000606971.1_RNA	NM_024294.2	NP_077270.1	Q9H6K1	CF106_HUMAN	chromosome 6 open reading frame 106	30										endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)	10						GCCTCTGGAACTCGGAGATGA	0.647000													5	21					0	0	1	0	0
KRTAP4-8	728224	broad.mit.edu	37	17	39254054	39254054	+	Missense_Mutation	SNP	A	A	T	rs76270529	by1000genomes	TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:39254054A>T	ENST00000333822.4	-	1	339	c.283T>A	c.(283-285)Tgc>Agc	p.C95S		NM_031960.2	NP_114166.1	Q9BYQ9	KRA48_HUMAN	keratin associated protein 4-8	95	25 X 5 AA repeats of C-C-[IKRQVHEC]- [SPRT]-[STCVQPR].					keratin filament		p.C95S(4)		endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|prostate(1)	11						ctggagatgcagcagcTAGGG	0.677000													4	96					0	0	1	0	0
KRT2	3849	broad.mit.edu	37	12	53045825	53045825	+	Silent	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:53045825C>G	ENST00000309680.3	-	1	123	c.102G>C	c.(100-102)cgG>cgC	p.R34R		NM_000423.2	NP_000414.2	P35908	K22E_HUMAN	keratin 2	34	Head.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(18)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32				BRCA - Breast invasive adenocarcinoma(357;0.19)		AAGTTGATCTCCGGCTTCCAC	0.602000													10	20					0	0	1	0	0
ACSM3	6296	broad.mit.edu	37	16	20787320	20787320	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:20787320C>T	ENST00000289416.5	+	3	854	c.379C>T	c.(379-381)Ctg>Ttg	p.L127L	ACSM3_ENST00000450120.2_Silent_p.L82L|ACSM3_ENST00000440284.2_Silent_p.L127L	NM_005622.3	NP_005613.2	Q53FZ2	ACSM3_HUMAN	acyl-CoA synthetase medium-chain family member 3	127					regulation of blood pressure	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)	21						AATTCTGATTCTGCCCAGGGT	0.463000													19	79					0	0	1	0	0
ZNF844	284391	broad.mit.edu	37	19	12187443	12187443	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:12187443C>G	ENST00000439326.3	+	4	1683	c.1508C>G	c.(1507-1509)cCt>cGt	p.P503R	ZNF844_ENST00000441304.2_3'UTR	NM_001136501.1	NP_001129973.1	Q08AG5	ZN844_HUMAN	zinc finger protein 844	503					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.P503R(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(1)|prostate(1)	10						GAGAGAAACCCTATGAGTGTA	0.413000													3	65					0	0	1	0	0
PIH1D1	55011	broad.mit.edu	37	19	49954846	49954846	+	Translation_Start_Site	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:49954846G>C	ENST00000262265.5	-	0	221				PIH1D1_ENST00000596049.1_Intron	NM_017916.2	NP_060386.1	Q9NWS0	PIHD1_HUMAN	PIH1 domain containing 1						box C/D snoRNP assembly	pre-snoRNP complex				NS(1)|breast(1)|kidney(1)|large_intestine(2)|lung(5)|urinary_tract(1)	11		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00152)|GBM - Glioblastoma multiforme(486;0.0244)		CTGGGAAAGAGATCTAGGCGT	0.607000													4	25					0	0	1	0	0
KBTBD3	143879	broad.mit.edu	37	11	105924026	105924026	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:105924026C>G	ENST00000526793.1	-	3	1549	c.1390G>C	c.(1390-1392)Gag>Cag	p.E464Q	KBTBD3_ENST00000534815.1_Missense_Mutation_p.E385Q|KBTBD3_ENST00000531837.1_Missense_Mutation_p.E464Q	NM_152433.3	NP_689646.2	Q8NAB2	KBTB3_HUMAN	kelch repeat and BTB (POZ) domain containing 3	460										NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	25		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		TCTGTAATCTCTACCTCTGAT	0.373000													25	28					0	0	1	0	0
PRB2	653247	broad.mit.edu	37	12	11546771	11546771	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:11546771G>C	ENST00000389362.4	-	3	276	c.241C>G	c.(241-243)Cca>Gca	p.P81A	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2									p.P81A(1)|p.P60A(1)		NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			TGTGGGGGTGGTCCTTGTGGC	0.612000													6	355					0	0	1	0	0
ARHGEF1	9138	broad.mit.edu	37	19	42407459	42407459	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:42407459G>A	ENST00000599846.1	+	20	2034	c.1909G>A	c.(1909-1911)Gag>Aag	p.E637K	ARHGEF1_ENST00000337665.4_Missense_Mutation_p.E596K|ARHGEF1_ENST00000354532.3_Missense_Mutation_p.E581K|ARHGEF1_ENST00000347545.4_Missense_Mutation_p.E548K|ARHGEF1_ENST00000378152.4_Missense_Mutation_p.E563K			Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor (GEF) 1	581					cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		GCCTGCAGAAGAGCCCACAGA	0.607000													5	21					0	0	1	0	0
SPESP1	246777	broad.mit.edu	37	15	69238236	69238236	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:69238236C>G	ENST00000310673.3	+	2	517	c.363C>G	c.(361-363)ttC>ttG	p.F121L	NOX5_ENST00000448182.3_Intron|SPESP1_ENST00000560188.1_3'UTR|RP11-809H16.2_ENST00000557966.1_RNA|NOX5_ENST00000455873.3_Intron|NOX5_ENST00000260364.5_Intron	NM_145658.3	NP_663633.1	Q6UW49	SPESP_HUMAN	sperm equatorial segment protein 1	121					multicellular organismal development	acrosomal vesicle				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	19						GTACCCCATTCTGGTCGATCA	0.428000													16	18					0	0	1	0	0
MGRN1	23295	broad.mit.edu	37	16	4721438	4721438	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:4721438A>T	ENST00000399577.5	+	9	866	c.773A>T	c.(772-774)aAc>aTc	p.N258I	MGRN1_ENST00000262370.7_Missense_Mutation_p.N258I|MGRN1_ENST00000415496.1_Missense_Mutation_p.N259I|MGRN1_ENST00000586183.1_Missense_Mutation_p.N258I|MGRN1_ENST00000588015.1_3'UTR|MGRN1_ENST00000588994.1_Missense_Mutation_p.N258I	NM_001142290.2	NP_001135762.1	O60291	MGRN1_HUMAN	mahogunin ring finger 1, E3 ubiquitin protein ligase	258					endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18						GGCATTGAGAACAAGAACAAC	0.587000													17	35					0	0	1	0	0
AFF1	4299	broad.mit.edu	37	4	87967934	87967934	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:87967934C>T	ENST00000307808.6	+	3	646	c.226C>T	c.(226-228)Cac>Tac	p.H76Y	AFF1_ENST00000395146.4_Missense_Mutation_p.H83Y|AFF1_ENST00000544085.1_Intron	NM_005935.2	NP_005926.1	P51825	AFF1_HUMAN	AF4/FMR2 family, member 1	76						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(2)	3		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		TACTAAGTCTCACACTCATCG	0.438000													70	275					0	0	1	0	0
ZNF77	58492	broad.mit.edu	37	19	2933592	2933592	+	Silent	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:2933592C>G	ENST00000314531.4	-	4	1625	c.1533G>C	c.(1531-1533)gtG>gtC	p.V511V		NM_021217.2	NP_067040.1	Q15935	ZNF77_HUMAN	zinc finger protein 77	511					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)	17				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|GBM - Glioblastoma multiforme(1328;2.11e-07)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.174)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTGCGTTCTCACGTGCACAC	0.493000													37	74					0	0	1	0	0
ZNF282	8427	broad.mit.edu	37	7	148921496	148921496	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:148921496C>G	ENST00000262085.3	+	8	1878	c.1773C>G	c.(1771-1773)aaC>aaG	p.N591K	ZNF282_ENST00000479907.1_3'UTR	NM_003575.2	NP_003566.1	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	591					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(3)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	17	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		ACCTGCAGAACCACCAGCGGC	0.632000													12	32					0	0	1	0	0
MORF4L1	10933	broad.mit.edu	37	15	79184578	79184578	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:79184578G>A	ENST00000331268.5	+	9	784	c.580G>A	c.(580-582)Gaa>Aaa	p.E194K	MORF4L1_ENST00000558502.1_Missense_Mutation_p.E67K|MORF4L1_ENST00000561171.1_Intron|MORF4L1_ENST00000379535.4_Missense_Mutation_p.E180K|MORF4L1_ENST00000558746.1_Missense_Mutation_p.E128K|MORF4L1_ENST00000426013.2_Missense_Mutation_p.E155K|MORF4L1_ENST00000559345.1_Missense_Mutation_p.E67K	NM_206839.2	NP_996670.1	Q9UBU8	MO4L1_HUMAN	mortality factor 4 like 1	194	Interaction with RB1-1.|Sufficient for interaction with PHF12.|Sufficient for interaction with SIN3A.				double-strand break repair via homologous recombination|histone deacetylation|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Sin3 complex	protein N-terminus binding			breast(1)|large_intestine(3)|lung(4)|prostate(1)|urinary_tract(1)	10						GAACAGAGTTGAAGTTAAAGT	0.388000													18	28					0	0	1	0	0
B4GALT6	9331	broad.mit.edu	37	18	29218639	29218639	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr18:29218639G>A	ENST00000306851.5	-	5	852	c.556C>T	c.(556-558)Cgg>Tgg	p.R186W	B4GALT6_ENST00000383131.3_Intron|B4GALT6_ENST00000237019.7_Missense_Mutation_p.R147W	NM_004775.3	NP_004766.2	Q9UBX8	B4GT6_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6	186					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(6)|pancreas(1)	20			OV - Ovarian serous cystadenocarcinoma(10;0.00791)			AATTCCAGCCGCTGCTTCTGG	0.358000													3	86					0	0	1	0	0
ZNF737	100129842	broad.mit.edu	37	19	20727954	20727954	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:20727954T>C	ENST00000427401.4	-	4	1149	c.1055A>G	c.(1054-1056)tAc>tGc	p.Y352C		NM_001159293.1	NP_001152765.1	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	352					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(2)|kidney(1)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	13						GGATGAGAAGTACTTAAAGGC	0.418000													20	36					0	0	1	0	0
DYNC1LI1	51143	broad.mit.edu	37	3	32582547	32582547	+	Silent	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:32582547T>C	ENST00000273130.4	-	5	823	c.720A>G	c.(718-720)gtA>gtG	p.V240V	DYNC1LI1_ENST00000432458.2_Silent_p.V124V	NM_016141.3	NP_057225.2	Q9Y6G9	DC1L1_HUMAN	dynein, cytoplasmic 1, light intermediate chain 1	240					cell division|interspecies interaction between organisms|mitosis|positive regulation of mitotic cell cycle spindle assembly checkpoint|transport	centrosome|condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|plasma membrane|spindle pole	ATP binding|motor activity			kidney(2)|large_intestine(1)|lung(3)|ovary(1)	7						AAACTACTAGTACTGGAATGC	0.413000													26	440					0	0	1	0	0
ZNF232	7775	broad.mit.edu	37	17	5009634	5009634	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:5009634C>T	ENST00000250076.3	-	5	1474	c.820G>A	c.(820-822)Gag>Aag	p.E274K	ZNF232_ENST00000575898.1_Missense_Mutation_p.E265K|ZNF232_ENST00000416429.2_3'UTR	NM_014519.2	NP_055334.2	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	247					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(1)|large_intestine(2)|liver(1)|lung(4)|ovary(1)|prostate(2)	11						CTCAGTCTCTCCGCTTTGGGA	0.478000													38	28					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124413237	124413237	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:124413237G>A	ENST00000291478.5	+	20	2536	c.2373G>A	c.(2371-2373)gtG>gtA	p.V791V	KALRN_ENST00000428018.2_Silent_p.V759V|KALRN_ENST00000360013.3_Silent_p.V2488V	NM_007064.3	NP_008995.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GGGACACAGTGATACTGCAGT	0.493000													48	104					0	0	1	0	0
ACIN1	22985	broad.mit.edu	37	14	23533582	23533582	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:23533582G>A	ENST00000262710.1	-	11	2925	c.2598C>T	c.(2596-2598)atC>atT	p.I866I	ACIN1_ENST00000357481.2_Silent_p.I108I|ACIN1_ENST00000457657.1_Silent_p.I826I|ACIN1_ENST00000605057.1_Silent_p.I808I|ACIN1_ENST00000555053.1_Silent_p.I865I|ACIN1_ENST00000338631.6_Silent_p.I139I|ACIN1_ENST00000397341.3_Silent_p.I108I|ACIN1_ENST00000557515.1_Silent_p.I107I	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	866					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		ATTCAGTGGTGATACTGATGG	0.587000													60	113					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86203124	86203124	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:86203124G>A	ENST00000370571.2	-	58	5103	c.4737C>T	c.(4735-4737)ttC>ttT	p.F1579F	COL24A1_ENST00000436319.1_Silent_p.F1558F	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	1579	Fibrillar collagen NC1.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		CACCAGCACTGAAATTGCAGA	0.353000													10	43					0	0	1	0	0
MPRIP	23164	broad.mit.edu	37	17	17083324	17083324	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:17083324G>A	ENST00000395811.5	+	22	3056	c.2967G>A	c.(2965-2967)atG>atA	p.M989I	MPRIP_ENST00000444976.1_Missense_Mutation_p.M951I|MPRIP_ENST00000395804.3_Missense_Mutation_p.M989I|RP11-45M22.3_ENST00000584203.1_RNA|MPRIP_ENST00000341712.4_Missense_Mutation_p.M989I	NM_015134.3|NM_201274.3	NP_055949.2|NP_958431.2	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase Rho interacting protein	989						cytoplasm|cytoskeleton	actin binding			biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	31						CAGATATAATGAAATCTAAAA	0.443000													18	13					0	0	1	0	0
JAGN1	84522	broad.mit.edu	37	3	9935060	9935060	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:9935060G>A	ENST00000307768.4	+	2	720	c.551G>A	c.(550-552)tGa>tAa	p.*184*		NM_032492.3	NP_115881.3	Q8N5M9	JAGN1_HUMAN	jagunal homolog 1 (Drosophila)	0						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(4)|lung(3)|ovary(1)	10	Medulloblastoma(99;0.227)					AAGCATAAATGAAGCCTCTTT	0.488000													4	10					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62758676	62758676	+	Splice_Site	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:62758676G>A	ENST00000512091.2	+	9	2326	c.1579G>A	c.(1579-1581)Ggt>Agt	p.G527S	LPHN3_ENST00000508693.1_Splice_Site_p.G595S|LPHN3_ENST00000506720.1_Splice_Site_p.G595S|LPHN3_ENST00000545650.1_Splice_Site_p.G527S|LPHN3_ENST00000514996.1_Splice_Site_p.G527S|LPHN3_ENST00000507164.1_Splice_Site_p.G595S|LPHN3_ENST00000506700.1_Splice_Site_p.G527S|LPHN3_ENST00000514591.1_Splice_Site_p.G527S|LPHN3_ENST00000506746.1_Splice_Site_p.G595S|LPHN3_ENST00000514157.1_Splice_Site_p.G527S|LPHN3_ENST00000507625.1_Splice_Site_p.G595S|LPHN3_ENST00000504896.1_Splice_Site_p.G527S|LPHN3_ENST00000509896.1_Splice_Site_p.G595S|LPHN3_ENST00000508946.1_Splice_Site_p.G527S|LPHN3_ENST00000511324.1_Splice_Site_p.G595S			Q9HAR2	LPHN3_HUMAN	latrophilin 3						neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						AGGAACTATAGGTAAGTCTGT	0.453000													2	5					0	0	1	0	0
SCAMP5	192683	broad.mit.edu	37	15	75308956	75308956	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:75308956G>A	ENST00000361900.6	+	5	366	c.159G>A	c.(157-159)gtG>gtA	p.V53V	SCAMP5_ENST00000425597.3_Silent_p.V53V|SCAMP5_ENST00000565923.1_3'UTR|SCAMP5_ENST00000545456.1_Intron|SCAMP5_ENST00000562212.1_Silent_p.V53V	NM_001178111.1	NP_001171582.1	Q8TAC9	SCAM5_HUMAN	secretory carrier membrane protein 5	53					exocytosis|negative regulation of endocytosis|positive regulation of calcium ion-dependent exocytosis|positive regulation of cytokine secretion|protein transport|response to endoplasmic reticulum stress	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane|trans-Golgi network membrane	protein binding			large_intestine(1)|lung(1)|ovary(1)|urinary_tract(2)	5						CGCTGGCCGTGAACCTGGTGG	0.617000													22	64					0	0	1	0	0
IGF1R	3480	broad.mit.edu	37	15	99459287	99459287	+	Silent	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:99459287G>C	ENST00000268035.6	+	9	2534	c.1923G>C	c.(1921-1923)ctG>ctC	p.L641L	IGF1R_ENST00000558762.1_Silent_p.L641L	NM_000875.3	NP_000866.1	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor	641	Fibronectin type-III 2.				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(13)|lung(20)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	ACGGCAACCTGAGTTACTACA	0.557000													45	51					0	0	1	0	0
MPP7	143098	broad.mit.edu	37	10	28348590	28348590	+	Silent	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:28348590T>C	ENST00000337532.5	-	15	1563	c.1287A>G	c.(1285-1287)gtA>gtG	p.V429V	MPP7_ENST00000375719.3_Silent_p.V429V|MPP7_ENST00000375732.1_Silent_p.V429V|MPP7_ENST00000540098.1_Silent_p.V429V|MPP7_ENST00000445954.2_Silent_p.V304V	NM_173496.3	NP_775767.2	Q5T2T1	MPP7_HUMAN	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	429	Guanylate kinase-like.				establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|stomach(1)	22						TGTTATTTTGTACATCTGTCT	0.358000													3	76					0	0	1	0	0
STAT1	6772	broad.mit.edu	37	2	191841752	191841752	+	Splice_Site	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:191841752C>G	ENST00000361099.3	-	22	2261		c.e22-1		STAT1_ENST00000540176.1_Splice_Site|STAT1_ENST00000409465.1_Splice_Site|STAT1_ENST00000392323.2_Splice_Site|STAT1_ENST00000392322.3_Splice_Site	NM_007315.3	NP_009330.1	P42224	STAT1_HUMAN	signal transducer and activator of transcription 1, 91kDa						activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	AAGTCAGGTTCTAAAAAGGAG	0.403000													23	45					0	0	1	0	0
POFUT1	23509	broad.mit.edu	37	20	30816133	30816133	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:30816133G>A	ENST00000375749.3	+	5	672	c.610G>A	c.(610-612)Gaa>Aaa	p.E204K	POFUT1_ENST00000539210.1_5'UTR|POFUT1_ENST00000486717.1_3'UTR	NM_015352.1	NP_056167.1	Q9H488	OFUT1_HUMAN	protein O-fucosyltransferase 1	204					fucose metabolic process|Notch signaling pathway|O-glycan processing|regulation of transcription, DNA-dependent	endoplasmic reticulum|membrane	peptide-O-fucosyltransferase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|urinary_tract(1)	6			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CGTCCTAGAGGAACACAGGCC	0.557000													20	40					0	0	1	0	0
LILRB5	10990	broad.mit.edu	37	19	54758713	54758713	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:54758713G>C	ENST00000450632.1	-	6	1190	c.1113C>G	c.(1111-1113)ttC>ttG	p.F371L	LILRB5_ENST00000316219.5_Missense_Mutation_p.F380L|LILRB5_ENST00000449561.2_Missense_Mutation_p.F380L|LILRB5_ENST00000345866.6_Missense_Mutation_p.F280L			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	380	Ig-like C2-type 4.				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GACTCATGGAGAATTCAGCCT	0.547000													27	87					0	0	1	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21355522	21355522	+	Silent	SNP	A	A	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:21355522A>G	ENST00000256958.2	+	10	1329	c.1233A>G	c.(1231-1233)tcA>tcG	p.S411S		NM_006446.4	NP_006437.3	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family, member 1B1	411					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	70					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	CCAAATTCTCATGTTTTACTG	0.343000													16	23					0	0	1	0	0
PDHX	8050	broad.mit.edu	37	11	35006268	35006268	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:35006268C>G	ENST00000448838.3	+	9	1372	c.1130C>G	c.(1129-1131)tCt>tGt	p.S377C	PDHX_ENST00000227868.4_Missense_Mutation_p.S392C|PDHX_ENST00000430469.2_Missense_Mutation_p.S165C|PDHX_ENST00000477173.3_3'UTR	NM_001135024.1|NM_003477.2	NP_001128496.1|NP_003468.2	O00330	ODPX_HUMAN	pyruvate dehydrogenase complex, component X	392					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	acyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)	16	all_epithelial(35;0.115)|Lung NSC(22;0.218)|all_lung(20;0.242)	all_hematologic(20;0.124)	STAD - Stomach adenocarcinoma(6;0.00113)			ATTGCTGACTCTGTAAAGGTA	0.358000													51	111					0	0	1	0	0
TXNDC2	84203	broad.mit.edu	37	18	9887461	9887461	+	Missense_Mutation	SNP	A	A	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr18:9887461A>C	ENST00000357775.5	+	2	1019	c.784A>C	c.(784-786)Atc>Ctc	p.I262L	TXNDC2_ENST00000536353.2_3'UTR|TXNDC2_ENST00000306084.6_Missense_Mutation_p.I329L	NM_032243.5	NP_115619.4	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)		22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						GGAGGGTGACATCCCCAAGTC	0.592000													4	143					0	0	1	0	0
ZNF441	126068	broad.mit.edu	37	19	11891595	11891595	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:11891595C>T	ENST00000357901.4	+	4	1058	c.956C>T	c.(955-957)tCt>tTt	p.S319F	ZNF441_ENST00000454339.2_Missense_Mutation_p.S252F	NM_152355.2	NP_689568.2	Q8N8Z8	ZN441_HUMAN	zinc finger protein 441	319					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GGCTTTCTTTCTCCCAGTTCA	0.403000													29	48					0	0	1	0	0
GALC	2581	broad.mit.edu	37	14	88459326	88459326	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:88459326G>A	ENST00000261304.2	-	1	289	c.183C>T	c.(181-183)gtC>gtT	p.V61V	GALC_ENST00000393569.2_Intron|GALC_ENST00000393568.4_Silent_p.V61V	NM_000153.3|NM_001201401.1	NP_000144.2|NP_001188330.1	P54803	GALC_HUMAN	galactosylceramidase	61					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CGCCGCCGCTGACCGCGCCGA	0.776000													5	3					0	0	1	0	0
TLX3	30012	broad.mit.edu	37	5	170736430	170736430	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:170736430G>T	ENST00000296921.5	+	1	143	c.61G>T	c.(61-63)Gac>Tac	p.D21Y		NM_021025.2	NP_066305.2	O43711	TLX3_HUMAN	T-cell leukemia homeobox 3	21						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00576)|all_lung(126;0.00963)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CTTCGGCATCGACCAGATCCT	0.781000			T	BCL11B	T-ALL								6	9					5.18039e-06	5.34943e-06	1	1	0
KEAP1	9817	broad.mit.edu	37	19	10602848	10602848	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:10602848C>T	ENST00000171111.5	-	3	1277	c.730G>A	c.(730-732)Gag>Aag	p.E244K	KEAP1_ENST00000588024.1_5'UTR|KEAP1_ENST00000393623.2_Missense_Mutation_p.E244K	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	244	BACK.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			TGGAAGACCTCGGACTCGCAG	0.627000													16	48					0	0	1	0	0
ITSN1	6453	broad.mit.edu	37	21	35166747	35166747	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:35166747G>C	ENST00000381318.3	+	17	2215	c.1927G>C	c.(1927-1929)Gaa>Caa	p.E643Q	ITSN1_ENST00000437442.2_Missense_Mutation_p.E643Q|ITSN1_ENST00000399355.2_Missense_Mutation_p.E643Q|ITSN1_ENST00000381285.4_Missense_Mutation_p.E643Q|ITSN1_ENST00000399326.3_Missense_Mutation_p.E643Q|ITSN1_ENST00000399352.1_Missense_Mutation_p.E643Q|ITSN1_ENST00000399353.1_Missense_Mutation_p.E606Q|ITSN1_ENST00000399338.4_Missense_Mutation_p.E643Q|ITSN1_ENST00000399349.1_Missense_Mutation_p.E643Q|ITSN1_ENST00000399367.3_Missense_Mutation_p.E643Q|ITSN1_ENST00000379960.5_Missense_Mutation_p.E643Q|ITSN1_ENST00000381291.4_Missense_Mutation_p.E643Q|AP000304.12_ENST00000429238.1_Intron	NM_003024.2	NP_003015.2	Q15811	ITSN1_HUMAN	intersectin 1 (SH3 domain protein)	643	KLERQ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(26)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	67						CATAGAATTAGAAAAACAAAA	0.383000													11	23					0	0	1	0	0
NEK4	6787	broad.mit.edu	37	3	52775460	52775460	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:52775460G>A	ENST00000233027.5	-	13	2262	c.2060C>T	c.(2059-2061)tCa>tTa	p.S687L	NEK4_ENST00000383721.4_Missense_Mutation_p.S641L|NEK4_ENST00000535191.1_Missense_Mutation_p.S598L	NM_001193533.1|NM_003157.4	NP_001180462.1|NP_003148.2	P51957	NEK4_HUMAN	NIMA-related kinase 4	687					cell division|mitosis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(10)	26				BRCA - Breast invasive adenocarcinoma(193;7.44e-05)|Kidney(197;0.000711)|KIRC - Kidney renal clear cell carcinoma(197;0.00086)|OV - Ovarian serous cystadenocarcinoma(275;0.0513)		CTTATCAGTTGAACTTGTAGA	0.328000													52	94					0	0	1	0	0
CCL1	6346	broad.mit.edu	37	17	32688819	32688819	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:32688819G>A	ENST00000225842.3	-	2	242	c.173C>T	c.(172-174)tCc>tTc	p.S58F		NM_002981.1	NP_002972.1	P22362	CCL1_HUMAN	chemokine (C-C motif) ligand 1	58					cellular calcium ion homeostasis|chemotaxis|immune response|signal transduction|viral reproduction	extracellular space	chemokine activity						Ovarian(249;0.0443)|Breast(31;0.133)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)|BRCA - Breast invasive adenocarcinoma(366;0.155)		GCCCTCATTGGAGCAGATGGA	0.483000											OREG0024322	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	82	182					0	0	1	0	0
POLE2	5427	broad.mit.edu	37	14	50118022	50118022	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:50118022G>A	ENST00000539565.2	-	15	1425	c.1207C>T	c.(1207-1209)Cgt>Tgt	p.R403C	POLE2_ENST00000554396.1_Missense_Mutation_p.R429C|POLE2_ENST00000556584.1_5'UTR|POLE2_ENST00000216367.5_Missense_Mutation_p.R429C	NM_001197330.1	NP_001184259.1	P56282	DPOE2_HUMAN	polymerase (DNA directed), epsilon 2, accessory subunit	429					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	10	all_epithelial(31;0.0021)|Breast(41;0.0124)					CTAGGAAAACGGACGCAGTTT	0.328000													3	37					0	0	1	0	0
NFKBIL1	4795	broad.mit.edu	37	6	31516038	31516038	+	Silent	SNP	C	C	T	rs144376753		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:31516038C>T	ENST00000376148.4	+	2	270	c.156C>T	c.(154-156)ctC>ctT	p.L52L	NFKBIL1_ENST00000376145.4_Silent_p.L52L	NM_005007.3	NP_004998.3	Q9UBC1	IKBL1_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1	52					cytoplasmic sequestering of transcription factor		protein binding			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|skin(1)	7						CCCAGGCCCTCCTCCAGCGAC	0.677000													19	17					0	0	1	0	0
MRPS30	10884	broad.mit.edu	37	5	44809390	44809390	+	Missense_Mutation	SNP	T	T	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:44809390T>A	ENST00000507110.1	+	1	364	c.326T>A	c.(325-327)tTc>tAc	p.F109Y		NM_016640.3	NP_057724.2	Q9NP92	RT30_HUMAN	mitochondrial ribosomal protein S30	109					apoptosis|translation	mitochondrion|ribosome	structural constituent of ribosome			central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(2)|lung(11)|prostate(1)	20	Lung NSC(6;8.08e-07)					TACCAGTACTTCACCAAGACC	0.622000													21	25					0	0	1	0	0
XPO5	57510	broad.mit.edu	37	6	43492227	43492227	+	Silent	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:43492227G>C	ENST00000265351.7	-	31	3669	c.3459C>G	c.(3457-3459)ctC>ctG	p.L1153L	POLR1C_ENST00000304004.3_Intron	NM_020750.2	NP_065801.1	Q9HAV4	XPO5_HUMAN	exportin 5	1153					gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(4)|lung(10)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	34	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			AACCAGCAATGAGGCGTTTGA	0.473000													11	42					0	0	1	0	0
OR52I2	143502	broad.mit.edu	37	11	4608419	4608419	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:4608419C>G	ENST00000312614.4	+	1	399	c.377C>G	c.(376-378)gCt>gGt	p.A126G		NM_001005170.2	NP_001005170.1	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I, member 2	126					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|pancreas(1)|skin(1)	19		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGCTTTAGTGCTTGTTTCACT	0.517000													33	28					0	0	1	0	0
C5orf42	65250	broad.mit.edu	37	5	37115115	37115115	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:37115115C>A	ENST00000274258.7	-	50	9466	c.5879G>T	c.(5878-5880)gGa>gTa	p.G1960V	C5orf42_ENST00000425232.2_Missense_Mutation_p.G3062V|C5orf42_ENST00000508244.1_Missense_Mutation_p.G3062V			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	3062										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			TGCTTTGGCTCCACCAGCTTT	0.363000													19	14					1.55795e-14	1.66967e-14	1	1	0
TUBG2	27175	broad.mit.edu	37	17	40818450	40818450	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:40818450C>T	ENST00000251412.7	+	10	1305	c.1106C>T	c.(1105-1107)tCg>tTg	p.S369L		NM_016437.2	NP_057521.1	Q9NRH3	TBG2_HUMAN	tubulin, gamma 2	369					G2/M transition of mitotic cell cycle|microtubule-based process|protein polymerization	cytosol	GTP binding|GTPase activity|structural molecule activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)	15		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.141)		TACCTGCCCTCGGCCCACCGG	0.607000													39	66					0	0	1	0	0
HNRNPDL	9987	broad.mit.edu	37	4	83350483	83350483	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:83350483C>G	ENST00000295470.5	-	1	536	c.361G>C	c.(361-363)Gag>Cag	p.E121Q	HNRNPDL_ENST00000349655.4_Missense_Mutation_p.E2Q|HNRNPDL_ENST00000602300.1_Missense_Mutation_p.E2Q|HNRNPDL_ENST00000514511.1_5'UTR|HNRNPDL_ENST00000502762.1_Missense_Mutation_p.E121Q	NM_001207000.1|NM_031372.3	NP_001193929.1|NP_112740.1			heterogeneous nuclear ribonucleoprotein D-like																		TTCATATCCTCCATAGTGACG	0.587000													67	63					0	0	1	0	0
SCRIB	23513	broad.mit.edu	37	8	144885702	144885702	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:144885702G>A	ENST00000356994.2	-	24	3460	c.3454C>T	c.(3454-3456)Cgt>Tgt	p.R1152C	SCRIB_ENST00000377533.3_Missense_Mutation_p.R1071C|SCRIB_ENST00000320476.3_Missense_Mutation_p.R1152C	NM_182706.4	NP_874365	Q14160	SCRIB_HUMAN	scribbled planar cell polarity protein	1152	Interaction with ARHGEF7.|PDZ 4.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding	p.R1152fs*38(1)		NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			AAACCCACACGCAGCCGACCG	0.721000													21	34					0	0	1	0	0
RIT2	6014	broad.mit.edu	37	18	40323592	40323592	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr18:40323592A>T	ENST00000326695.5	-	5	691	c.520T>A	c.(520-522)Ttt>Att	p.F174I	RIT2_ENST00000590910.1_3'UTR|RIT2_ENST00000589109.1_3'UTR	NM_002930.2	NP_002921.1	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	174					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						AAGCCATGAAAAGCATCATCA	0.428000													20	33					0	0	1	0	0
DNAJC13	23317	broad.mit.edu	37	3	132213965	132213965	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:132213965C>G	ENST00000260818.6	+	35	4223	c.3975C>G	c.(3973-3975)ttC>ttG	p.F1325L		NM_015268.3	NP_056083.3	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1325	J.						heat shock protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|urinary_tract(1)	34						AAGCTTACTTCAGACTTGCAC	0.378000													16	36					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87150136	87150136	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:87150136C>A	ENST00000265724.3	-	23	3159	c.2742G>T	c.(2740-2742)caG>caT	p.Q914H	ABCB1_ENST00000488737.2_5'UTR|ABCB1_ENST00000543898.1_Missense_Mutation_p.Q850H	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	914	ABC transmembrane type-1 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GTTCAAACTTCTGCTCCTGAG	0.408000													36	64					6.4771e-29	7.11159e-29	1	1	0
MUC17	140453	broad.mit.edu	37	7	100678824	100678824	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:100678824C>T	ENST00000306151.4	+	3	4191	c.4127C>T	c.(4126-4128)tCa>tTa	p.S1376L		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1376	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GAAGCCTGTTCATCTCCTACA	0.493000													128	301					0	0	1	0	0
HNRNPF	3185	broad.mit.edu	37	10	43883167	43883167	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:43883167C>G	ENST00000443950.2	-	3	652	c.166G>C	c.(166-168)Gag>Cag	p.E56Q	HNRNPF_ENST00000356053.3_Missense_Mutation_p.E56Q|HNRNPF_ENST00000337970.3_Missense_Mutation_p.E56Q|HNRNPF_ENST00000498176.1_5'UTR|HNRNPF_ENST00000544000.1_Missense_Mutation_p.E56Q|HNRNPF_ENST00000357065.4_Missense_Mutation_p.E56Q	NM_001098208.1	NP_001091678.1	P52597	HNRPF_HUMAN	heterogeneous nuclear ribonucleoprotein F	56	RRM 1.				regulation of RNA splicing	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|urinary_tract(1)	19						ACAAAAGCCTCACCACTCTGC	0.493000													25	38					0	0	1	0	0
OR2B6	26212	broad.mit.edu	37	6	27925668	27925668	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:27925668C>T	ENST00000244623.1	+	1	650	c.650C>T	c.(649-651)tCa>tTa	p.S217L		NM_012367.1	NP_036499.1	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B, member 6	217					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						ATCCTTATATCATATGCTTTT	0.423000													40	169					0	0	1	0	0
ZNF502	91392	broad.mit.edu	37	3	44763165	44763165	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:44763165C>T	ENST00000296091.4	+	4	1112	c.856C>T	c.(856-858)Cag>Tag	p.Q286*	ZNF502_ENST00000449836.1_Nonsense_Mutation_p.Q286*|ZNF502_ENST00000436624.2_Nonsense_Mutation_p.Q286*	NM_001134440.1|NM_001282880.1|NM_033210.4	NP_001127912.1|NP_001269809.1|NP_149987.2	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	286					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|large_intestine(8)|lung(4)|prostate(1)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		TATTCATCATCAGAGAATTCA	0.403000													169	261					0	0	1	0	0
POLR3C	10623	broad.mit.edu	37	1	145609263	145609263	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:145609263C>G	ENST00000334163.3	-	2	234	c.74G>C	c.(73-75)gGa>gCa	p.G25A	POLR3C_ENST00000369294.1_Missense_Mutation_p.G25A|POLR3C_ENST00000471254.1_5'UTR	NM_006468.6	NP_006459.3	Q9BUI4	RPC3_HUMAN	polymerase (RNA) III (DNA directed) polypeptide C (62kD)	25					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)		Epithelial(2;7.55e-13)			CAGATGGACTCCAATTTTTTC	0.428000													16	72					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108236128	108236128	+	Nonsense_Mutation	SNP	G	G	T	rs56253573		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:108236128G>T	ENST00000278616.4	+	63	9449	c.9064G>T	c.(9064-9066)Gaa>Taa	p.E3022*	C11orf65_ENST00000526725.1_Intron|ATM_ENST00000525178.1_3'UTR|ATM_ENST00000452508.2_Nonsense_Mutation_p.E3022*|C11orf65_ENST00000525729.1_Intron	NM_000051.3	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	3022					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		AGGAGTGGAAGAAGGCACTGT	0.433000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			17	59					3.01185e-09	3.18345e-09	1	1	0
RRM2	6241	broad.mit.edu	37	2	10263127	10263127	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:10263127G>A	ENST00000360566.2	+	2	588	c.297G>A	c.(295-297)ggG>ggA	p.G99G	RRM2_ENST00000304567.5_Silent_p.G39G	NM_001165931.1	NP_001159403.1	P31350	RIR2_HUMAN	ribonucleotide reductase M2	39					deoxyribonucleoside diphosphate metabolic process|deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol	ribonucleoside-diphosphate reductase activity|transition metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(7)|skin(1)	19	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)|OV - Ovarian serous cystadenocarcinoma(76;0.221)		CCCTGAGCGGGACCCGCGTCC	0.751000													3	5					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	41385232	41385232	+	Silent	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:41385232G>C	ENST00000373198.4	-	6	964	c.729C>G	c.(727-729)gtC>gtG	p.V243V	PTPRT_ENST00000373201.1_Silent_p.V243V|PTPRT_ENST00000373187.1_Silent_p.V243V|PTPRT_ENST00000356100.2_Silent_p.V243V|PTPRT_ENST00000373190.1_Silent_p.V243V|PTPRT_ENST00000373184.1_Silent_p.V243V|PTPRT_ENST00000373193.3_Silent_p.V243V	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T		Ig-like C2-type.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GCCTGTGGTTGACCACACGGG	0.582000													7	21					0	0	1	0	0
FANCI	55215	broad.mit.edu	37	15	89834929	89834929	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:89834929C>G	ENST00000310775.7	+	20	2062	c.1976C>G	c.(1975-1977)tCt>tGt	p.S659C	FANCI_ENST00000300027.8_Missense_Mutation_p.S659C	NM_001113378.1	NP_001106849.1	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I	659					cell cycle|DNA repair	nucleoplasm	protein binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	Lung NSC(78;0.0472)|all_lung(78;0.089)					GATAAGATCTCTCTACAAGAA	0.378000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				27	55					0	0	1	0	0
KDM1A	23028	broad.mit.edu	37	1	23376901	23376901	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:23376901A>G	ENST00000400181.4	+	4	703	c.599A>G	c.(598-600)cAg>cGg	p.Q200R	KDM1A_ENST00000356634.3_Missense_Mutation_p.Q180R|KDM1A_ENST00000542151.1_Missense_Mutation_p.Q200R|RP1-184J9.2_ENST00000427154.1_RNA	NM_001009999.2	NP_001009999.1	O60341	KDM1A_HUMAN	lysine (K)-specific demethylase 1A	180	SWIRM.				blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			breast(2)|central_nervous_system(2)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						GCAGCTTTCCAGAGCCGACTT	0.448000													19	59					0	0	1	0	0
KCNF1	3754	broad.mit.edu	37	2	11053189	11053189	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:11053189G>A	ENST00000295082.1	+	1	1127	c.637G>A	c.(637-639)Gag>Aag	p.E213K		NM_002236.4	NP_002227.2	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F, member 1	213						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(2)|skin(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		GCTGGACGCCGAGGGCAACCG	0.667000													18	22					0	0	1	0	0
SHROOM1	134549	broad.mit.edu	37	5	132160501	132160501	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:132160501C>G	ENST00000378679.3	-	6	1851	c.1047G>C	c.(1045-1047)caG>caC	p.Q349H	SHROOM1_ENST00000319854.3_Missense_Mutation_p.Q349H|SHROOM1_ENST00000378676.1_Intron	NM_001172700.1	NP_001166171.1	Q2M3G4	SHRM1_HUMAN	shroom family member 1	349					actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			endometrium(1)|kidney(4)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	17			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CAGCCTCTTTCTGAGGCAAGA	0.542000													4	22					0	0	1	0	0
PIBF1	10464	broad.mit.edu	37	13	73409499	73409499	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr13:73409499G>C	ENST00000326291.6	+	9	1554	c.1216G>C	c.(1216-1218)Gaa>Caa	p.E406Q		NM_006346.2	NP_006337.2	Q8WXW3	PIBF1_HUMAN	progesterone immunomodulatory binding factor 1	406						centrosome				breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	24		Prostate(6;0.00191)|Breast(118;0.0736)|Acute lymphoblastic leukemia(28;0.0865)		GBM - Glioblastoma multiforme(99;0.000664)		GTATGAACGAGAAAACAGGTA	0.269000													18	48					0	0	1	0	0
AK7	122481	broad.mit.edu	37	14	96924468	96924468	+	Missense_Mutation	SNP	G	G	C	rs149622950	by1000genomes	TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:96924468G>C	ENST00000267584.4	+	12	1320	c.1276G>C	c.(1276-1278)Gaa>Caa	p.E426Q		NM_152327.3	NP_689540.2	Q96M32	KAD7_HUMAN	adenylate kinase 7	426	Adenylate kinase.|Poly-Glu.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity	p.E426K(1)		breast(2)|cervix(2)|endometrium(3)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		agaagaagtcgaagaggaaga	0.507000													18	20					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77714227	77714227	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr13:77714227C>T	ENST00000407578.2	-	51	7739	c.7473G>A	c.(7471-7473)caG>caA	p.Q2491Q	MYCBP2_ENST00000360084.5_5'UTR|MYCBP2_ENST00000544440.2_Silent_p.Q2453Q|MYCBP2_ENST00000357337.6_Silent_p.Q2453Q	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	2453					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CTATGCCTATCTGCTCACTCT	0.423000													10	36					0	0	1	0	0
NIPAL3	57185	broad.mit.edu	37	1	24768670	24768670	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:24768670C>T	ENST00000003912.3	+	5	757	c.42C>T	c.(40-42)ttC>ttT	p.F14F	NIPAL3_ENST00000374399.4_Silent_p.F96F|NIPAL3_ENST00000358028.4_Silent_p.F96F|NIPAL3_ENST00000428131.1_Silent_p.F96F|NIPAL3_ENST00000339255.2_Silent_p.F96F			Q6P499	NPAL3_HUMAN	NIPA-like domain containing 3	96						integral to membrane				endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|skin(1)	14						CCTACGCCTTCGCGCCGCTGT	0.632000													50	93					0	0	1	0	0
PHF8	23133	broad.mit.edu	37	X	54048789	54048789	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chrX:54048789G>A	ENST00000338154.6	-	4	700	c.196C>T	c.(196-198)Cgt>Tgt	p.R66C	PHF8_ENST00000338946.6_Missense_Mutation_p.R66C|PHF8_ENST00000357988.5_Missense_Mutation_p.R102C|PHF8_ENST00000322659.8_Missense_Mutation_p.R66C	NM_015107.2	NP_055922.1	Q9UPP1	PHF8_HUMAN	PHD finger protein 8	102					brain development|G1/S transition of mitotic cell cycle|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase I promoter|transcription, DNA-dependent	nucleolus	chromatin binding|histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	40						GAAGATCCACGGCGTTTTTTC	0.493000													43	17					0	0	1	0	0
GLTSCR1	29998	broad.mit.edu	37	19	48197590	48197590	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:48197590C>G	ENST00000396720.3	+	8	2696	c.2502C>G	c.(2500-2502)atC>atG	p.I834M	CTD-2571L23.8_ENST00000599924.1_lincRNA	NM_015711.3	NP_056526.3	Q9NZM4	GSCR1_HUMAN	glioma tumor suppressor candidate region gene 1	834							protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|pancreas(3)|prostate(4)|skin(2)	20		all_cancers(25;1.8e-07)|all_lung(116;5.73e-06)|Lung NSC(112;9.69e-06)|all_epithelial(76;2.42e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000358)|OV - Ovarian serous cystadenocarcinoma(262;0.000576)|Epithelial(262;0.0212)|GBM - Glioblastoma multiforme(486;0.0355)		TGCCTGGCATCTTTGTCATCC	0.721000													19	9					0	0	1	0	0
SEPHS1	22929	broad.mit.edu	37	10	13361208	13361208	+	Silent	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:13361208C>G	ENST00000327347.5	-	9	1488	c.1113G>C	c.(1111-1113)cgG>cgC	p.R371R	SEPHS1_ENST00000378614.4_Silent_p.R300R|SEPHS1_ENST00000537130.1_Silent_p.R304R|SEPHS1_ENST00000545675.1_3'UTR	NM_001195602.1|NM_012247.4	NP_001182531.1|NP_036379.2	P49903	SPS1_HUMAN	selenophosphate synthetase 1	371					protein modification process		ATP binding|GTP binding|selenide, water dikinase activity			cervix(1)|endometrium(3)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|stomach(1)	16						CCTCGATGATCCGGGGTTTGT	0.478000													79	195					0	0	1	0	0
TMPRSS3	64699	broad.mit.edu	37	21	43800263	43800263	+	Silent	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:43800263C>A	ENST00000291532.3	-	10	1966	c.1011G>T	c.(1009-1011)gtG>gtT	p.V337V	TMPRSS3_ENST00000433957.2_Silent_p.V337V|TMPRSS3_ENST00000474596.1_5'UTR|TMPRSS3_ENST00000398405.1_Silent_p.V335V|TMPRSS3_ENST00000380399.1_Silent_p.V421V	NM_032404.2	NP_115780.1	P57727	TMPS3_HUMAN	transmembrane protease, serine 3	337	Peptidase S1.				cellular sodium ion homeostasis|proteolysis	endoplasmic reticulum membrane|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity|sodium channel regulator activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(4)|skin(1)	13						ACGTCCAGCACACTTTTCCAT	0.557000													3	46					1.024e-07	1.0739e-07	1	1	0
DNHD1	144132	broad.mit.edu	37	11	6591874	6591874	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:6591874G>C	ENST00000254579.6	+	42	13696	c.13132G>C	c.(13132-13134)Gag>Cag	p.E4378Q	DNHD1_ENST00000527990.2_Missense_Mutation_p.E4378Q	NM_144666.2	NP_653267.2	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1	4378					microtubule-based movement	dynein complex	microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(13)|kidney(6)|large_intestine(11)|lung(14)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	55		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		TGCAATGGCAGAGTGCAAGGC	0.617000													2	7					0	0	1	0	0
PIP4K2A	5305	broad.mit.edu	37	10	22830915	22830915	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:22830915C>G	ENST00000376573.4	-	8	1082	c.854G>C	c.(853-855)aGa>aCa	p.R285T	PIP4K2A_ENST00000323883.7_Missense_Mutation_p.R145T|PIP4K2A_ENST00000545335.1_Missense_Mutation_p.R226T	NM_005028.4	NP_005019.2	P48426	PI42A_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	285	PIPK.						1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding			endometrium(4)|kidney(13)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	29						CTGTTCGGCTCTCTCCACATC	0.607000													33	56					0	0	1	0	0
SPTAN1	6709	broad.mit.edu	37	9	131340465	131340465	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:131340465G>T	ENST00000358161.5	+	9	1275	c.1162G>T	c.(1162-1164)Gag>Tag	p.E388*	SPTAN1_ENST00000372731.4_Nonsense_Mutation_p.E388*|SPTAN1_ENST00000372739.3_Nonsense_Mutation_p.E388*			Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	388					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						CAATGCAGATGAGCTTGCCAG	0.488000													21	40					5.61819e-17	6.08166e-17	1	1	0
IFNAR1	3454	broad.mit.edu	37	21	34717656	34717656	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:34717656C>T	ENST00000270139.3	+	6	930	c.778C>T	c.(778-780)Cag>Tag	p.Q260*	IFNAR1_ENST00000416947.2_Nonsense_Mutation_p.Q191*|IFNAR1_ENST00000442357.2_Nonsense_Mutation_p.Q260*	NM_000629.2	NP_000620.2	P17181	INAR1_HUMAN	interferon (alpha, beta and omega) receptor 1	260	Fibronectin type-III 2.				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	integral to plasma membrane	type I interferon receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|skin(2)	14					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	CTTTCAAGTTCAGTGGCTCCA	0.383000													9	28					0	0	1	0	0
UBE2C	11065	broad.mit.edu	37	20	44442074	44442074	+	Splice_Site	SNP	A	A	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:44442074A>G	ENST00000372568.4	+	2	285		c.e2-1		UBE2C_ENST00000335046.3_Splice_Site|UBE2C_ENST00000352551.5_Splice_Site|UBE2C_ENST00000356455.4_Splice_Site|UBE2C_ENST00000405520.1_5'UTR|UBE2C_ENST00000243893.6_Splice_Site	NM_181801.2	NP_861517.1	O00762	UBE2C_HUMAN	ubiquitin-conjugating enzyme E2C						activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|exit from mitosis|free ubiquitin chain polymerization|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|positive regulation of exit from mitosis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|protein K48-linked ubiquitination|spindle organization	anaphase-promoting complex|cytosol|nucleoplasm	ATP binding|protein binding|ubiquitin-protein ligase activity			large_intestine(2)|lung(2)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				CTCTTTTTTCAGGCTACAGCA	0.542000													32	125					0	0	1	0	0
ZNF492	57615	broad.mit.edu	37	19	22847715	22847715	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:22847715A>G	ENST00000456783.2	+	4	1488	c.1244A>G	c.(1243-1245)cAt>cGt	p.H415R		NM_020855.2	NP_065906.1	Q9P255	ZN492_HUMAN	zinc finger protein 492	415					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				AAGATAATTCATACTGGAGAG	0.378000													27	54					0	0	1	0	0
OR5M11	219487	broad.mit.edu	37	11	56310058	56310058	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:56310058G>A	ENST00000528616.2	-	1	699	c.676C>T	c.(676-678)Cgg>Tgg	p.R226W		NM_001005245.1	NP_001005245.1	Q96RB7	OR5MB_HUMAN	olfactory receptor, family 5, subfamily M, member 11	226					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(14)	18						GATTTGATCCGGAGGATGGCA	0.493000													23	48					0	0	1	0	0
REPIN1	29803	broad.mit.edu	37	7	150068792	150068792	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:150068792C>T	ENST00000397281.2	+	4	951	c.462C>T	c.(460-462)ttC>ttT	p.F154F	REPIN1_ENST00000540729.1_Silent_p.F154F|REPIN1_ENST00000425389.2_Silent_p.F154F|REPIN1_ENST00000466559.1_3'UTR|REPIN1_ENST00000489432.2_Silent_p.F211F|REPIN1_ENST00000482680.1_3'UTR|RP4-584D14.5_ENST00000488310.1_RNA|REPIN1_ENST00000479668.1_3'UTR|REPIN1_ENST00000444957.1_Silent_p.F154F	NM_013400.3	NP_037532.2	Q9BWE0	REPI1_HUMAN	replication initiator 1	154					DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			cervix(2)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	14	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			AGAGACGCTTCTGGCGACGAA	0.662000													6	6					0	0	1	0	0
KIN	22944	broad.mit.edu	37	10	7829810	7829810	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:7829810C>G	ENST00000379562.4	-	1	134	c.87G>C	c.(85-87)caG>caC	p.Q29H	KIN_ENST00000543003.1_5'UTR|KIN_ENST00000535925.1_Missense_Mutation_p.Q29H	NM_012311.3	NP_036443.1	O60870	KIN17_HUMAN	KIN, antigenic determinant of recA protein homolog (mouse)						DNA recombination|DNA repair|DNA replication|interspecies interaction between organisms|mRNA processing	cytoplasm|nuclear matrix	double-stranded DNA binding|RNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|skin(2)	19						TCTGGCACATCTGGCAATACC	0.627000													73	117					0	0	1	0	0
THAP3	90326	broad.mit.edu	37	1	6688662	6688662	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:6688662C>T	ENST00000377627.3	+	2	205	c.178C>T	c.(178-180)Cgg>Tgg	p.R60W	THAP3_ENST00000307896.6_Missense_Mutation_p.R60W|THAP3_ENST00000054650.4_Missense_Mutation_p.R60W	NM_138350.3	NP_612359.2	Q8WTV1	THAP3_HUMAN	THAP domain containing, apoptosis associated protein 3	60							DNA binding|metal ion binding			breast(1)|cervix(1)|large_intestine(1)|prostate(1)	4	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		CGAGCACTTCCGGCCAGAGTG	0.607000													19	24					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19468063	19468063	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:19468063T>C	ENST00000219821.5	+	1	292	c.35T>C	c.(34-36)aTa>aCa	p.I12T	TMC5_ENST00000561503.1_5'UTR|TMC5_ENST00000396229.2_Intron|TMC5_ENST00000564959.1_Missense_Mutation_p.I12T|TMC5_ENST00000541464.1_Intron|TMC5_ENST00000542583.2_Intron|TMC5_ENST00000381414.4_Intron	NM_024780.4	NP_079056.2	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	0						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						GAAATCATCATACAGGTTGAG	0.483000													21	68					0	0	1	0	0
LRRC37B	114659	broad.mit.edu	37	17	30348940	30348940	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:30348940C>G	ENST00000327564.7	+	1	917	c.856C>G	c.(856-858)Caa>Gaa	p.Q286E	LRRC37B_ENST00000543378.2_Missense_Mutation_p.Q177E|LRRC37B_ENST00000394713.3_Missense_Mutation_p.Q259E|LRRC37B_ENST00000584368.1_Missense_Mutation_p.Q271E|LRRC37B_ENST00000341671.7_Missense_Mutation_p.Q259E			Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B	259						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	29		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				TGGACTTTCTCAATTCCATCT	0.527000													57	118					0	0	1	0	0
MYO19	80179	broad.mit.edu	37	17	34856680	34856680	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:34856680G>A	ENST00000431794.3	-	23	2889	c.2367C>T	c.(2365-2367)ctC>ctT	p.L789L	MYO19_ENST00000268852.9_Silent_p.L589L	NM_001163735.1	NP_001157207.1	Q96H55	MYO19_HUMAN	myosin XIX	789	IQ 2.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|urinary_tract(1)	20		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		CTGCCTGGATGAGCATGACGG	0.647000													3	22					0	0	1	0	0
PRTG	283659	broad.mit.edu	37	15	55912272	55912272	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:55912272G>T	ENST00000389286.4	-	20	3438	c.3391C>A	c.(3391-3393)Cat>Aat	p.H1131N		NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	1131					multicellular organismal development	integral to membrane				breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		TTGGACTCATGAGAAAACCGC	0.483000													30	44					1.36615e-20	1.48783e-20	1	1	0
CNGB1	1258	broad.mit.edu	37	16	57945763	57945763	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:57945763C>A	ENST00000564448.1	-	25	2428	c.2368G>T	c.(2368-2370)Gcc>Tcc	p.A790S	CNGB1_ENST00000251102.8_Missense_Mutation_p.A796S			Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1	796					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						AGAAGGTAGGCTGTGGTCCTG	0.562000													3	23					0.184627	0.185316	1	1	0
ZNF574	64763	broad.mit.edu	37	19	42583877	42583877	+	Silent	SNP	C	C	T	rs113091672		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:42583877C>T	ENST00000600245.1	+	2	1774	c.1119C>T	c.(1117-1119)ttC>ttT	p.F373F	CTB-59C6.3_ENST00000594531.1_RNA|ZNF574_ENST00000359044.4_Silent_p.F373F|ZNF574_ENST00000222339.7_Silent_p.F463F			Q6ZN55	ZN574_HUMAN	zinc finger protein 574	373					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20		Prostate(69;0.059)				GCCTGGCCTTCGGCACAGAGG	0.587000													7	31					0	0	1	0	0
TEP1	7011	broad.mit.edu	37	14	20848600	20848600	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:20848600G>A	ENST00000262715.5	-	34	4837	c.4797C>T	c.(4795-4797)ccC>ccT	p.P1599P	TEP1_ENST00000556935.1_Silent_p.P1491P|TEP1_ENST00000545983.1_5'UTR	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1599					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CGTCAGCCTCGGGGAGCTTTT	0.587000													5	36					0	0	1	0	0
HIPK4	147746	broad.mit.edu	37	19	40886736	40886736	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:40886736C>A	ENST00000291823.2	-	3	1446	c.1162G>T	c.(1162-1164)Gat>Tat	p.D388Y		NM_144685.3	NP_653286.2	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	388						cytoplasm	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	20			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			GGGGTCCCATCTTCTGCGGCC	0.662000													39	41					9.57592e-29	1.04926e-28	1	1	0
SOS2	6655	broad.mit.edu	37	14	50585132	50585132	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:50585132T>C	ENST00000216373.5	-	23	4203	c.3929A>G	c.(3928-3930)tAc>tGc	p.Y1310C	SOS2_ENST00000543680.1_Missense_Mutation_p.Y1277C	NM_006939.2	NP_008870.2	Q07890	SOS2_HUMAN	son of sevenless homolog 2 (Drosophila)	1310					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(16)|ovary(2)|skin(1)	39	all_epithelial(31;0.000822)|Breast(41;0.0065)					CTCCCGTTTGTAAGTCTTTGG	0.483000													35	37					0	0	1	0	0
RNF40	9810	broad.mit.edu	37	16	30780218	30780218	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:30780218G>C	ENST00000324685.6	+	15	2592	c.2157G>C	c.(2155-2157)aaG>aaC	p.K719N	RNF40_ENST00000563683.1_Missense_Mutation_p.K679N|RNF40_ENST00000357890.5_Missense_Mutation_p.K619N|RNF40_ENST00000402121.3_Missense_Mutation_p.K411N	NM_001207033.1|NM_014771.3	NP_001193962.1|NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40, E3 ubiquitin protein ligase	719					histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)	30			Colorectal(24;0.198)			GGGAGAGCAAGAAGATCGCGG	0.592000													122	60					0	0	1	0	0
IL10RB	3588	broad.mit.edu	37	21	34640812	34640812	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:34640812C>T	ENST00000290200.2	+	2	271	c.163C>T	c.(163-165)Cag>Tag	p.Q55*	AP000295.9_ENST00000433395.2_Silent_p.L182L	NM_000628.4	NP_000619.3			interleukin 10 receptor, beta											endometrium(1)|kidney(1)|large_intestine(6)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	14						TTTCACAGCTCAGTACCTAAG	0.532000													20	60					0	0	1	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58357784	58357784	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:58357784G>A	ENST00000249750.4	-	1	832	c.65C>T	c.(64-66)tCg>tTg	p.S22L	CTD-2330J20.2_ENST00000559684.1_RNA|ALDH1A2_ENST00000347587.3_Missense_Mutation_p.S22L|ALDH1A2_ENST00000537372.1_5'UTR|ALDH1A2_ENST00000558231.1_Intron	NM_003888.3	NP_003879.2	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1 family, member A2	22					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	GAGGTGCAGCGACGCCATGAG	0.662000													10	17					0	0	1	0	0
SRBD1	55133	broad.mit.edu	37	2	45616464	45616464	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:45616464G>A	ENST00000263736.4	-	21	3035	c.2973C>T	c.(2971-2973)ctC>ctT	p.L991L	SRBD1_ENST00000535761.1_Silent_p.L510L|SRBD1_ENST00000490133.1_5'UTR	NM_018079.4	NP_060549.4	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	991	S1 motif.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(13)|large_intestine(8)|lung(15)|skin(2)|stomach(1)|urinary_tract(1)	49		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			ACACCCGAATGAGGTCCAGAG	0.448000													37	69					0	0	1	0	0
CCDC151	115948	broad.mit.edu	37	19	11545659	11545659	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:11545659C>G	ENST00000356392.4	-	1	266	c.179G>C	c.(178-180)aGa>aCa	p.R60T	CCDC151_ENST00000591179.1_Missense_Mutation_p.R60T|CCDC151_ENST00000586836.1_Intron|CCDC151_ENST00000545100.1_Intron	NM_145045.4	NP_659482.3	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	60										endometrium(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	12						CCCTGCACCTCTGTGGAAGGA	0.597000											OREG0025257	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	58					0	0	1	0	0
NR1H2	7376	broad.mit.edu	37	19	50881973	50881973	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:50881973C>T	ENST00000253727.5	+	6	902	c.667C>T	c.(667-669)Caa>Taa	p.Q223*	NR1H2_ENST00000542413.1_5'UTR|NR1H2_ENST00000599105.1_Nonsense_Mutation_p.Q223*|NR1H2_ENST00000593926.1_Nonsense_Mutation_p.Q223*|NR1H2_ENST00000598168.1_Nonsense_Mutation_p.Q223*|NR1H2_ENST00000411902.2_Nonsense_Mutation_p.Q126*	NM_007121.5	NP_009052	P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	223					negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(2)	8		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		AACAGCGGCTCAAGAACTAAT	0.632000													27	30					0	0	1	0	0
TRIM5	85363	broad.mit.edu	37	11	5686256	5686256	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:5686256G>A	ENST00000305836.5	-	8	1567	c.1265C>T	c.(1264-1266)tCt>tTt	p.S422F	TRIM5_ENST00000380027.1_Intron|TRIM5_ENST00000380034.3_Missense_Mutation_p.S422F|TRIM5_ENST00000483835.1_Intron|TRIM5_ENST00000396855.3_Intron|TRIM5_ENST00000396853.4_Intron|TRIM5_ENST00000396847.3_3'UTR			Q9C035	TRIM5_HUMAN	tripartite motif containing 5	422	B30.2/SPRY.				interspecies interaction between organisms|protein trimerization|response to virus	cytoplasm|cytoplasmic mRNA processing body	ligase activity|protein binding|protein homodimerization activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)|Lung NSC(207;0.138)|all_lung(207;0.221)		Epithelial(150;7.21e-09)|BRCA - Breast invasive adenocarcinoma(625;0.139)		GAAAGGAACAGAAGGAGTATG	0.398000													34	34					0	0	1	0	0
KIAA1244	57221	broad.mit.edu	37	6	138655808	138655808	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:138655808C>T	ENST00000251691.4	+	33	5991	c.5825C>T	c.(5824-5826)tCc>tTc	p.S1942F		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	1942					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		ATCCTGCCCTCCTTCCAGTCC	0.577000													7	30					0	0	1	0	0
BBS9	27241	broad.mit.edu	37	7	33407465	33407465	+	Missense_Mutation	SNP	A	A	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:33407465A>C	ENST00000242067.6	+	17	2301	c.1780A>C	c.(1780-1782)Aaa>Caa	p.K594Q	BBS9_ENST00000354265.4_Missense_Mutation_p.K559Q|BBS9_ENST00000396127.2_Missense_Mutation_p.K559Q|BBS9_ENST00000355070.2_Missense_Mutation_p.K589Q|BBS9_ENST00000350941.3_Missense_Mutation_p.K554Q	NM_198428.2	NP_940820.1	Q3SYG4	PTHB1_HUMAN	Bardet-Biedl syndrome 9	594					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding		BBS9/PKD1L1(2)	NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	50			GBM - Glioblastoma multiforme(11;0.0894)			TCTTGCTTCCAAAACTTCTCG	0.363000									Bardet-Biedl syndrome				12	49					0	0	1	0	0
BBS5	129880	broad.mit.edu	37	2	170356086	170356086	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:170356086T>C	ENST00000295240.3	+	9	1148	c.772T>C	c.(772-774)Tct>Cct	p.S258P	BBS5_ENST00000392663.2_Missense_Mutation_p.S237P|RP11-724O16.1_ENST00000513963.1_Missense_Mutation_p.S258P|BBS5_ENST00000554017.1_Missense_Mutation_p.S258P	NM_152384.2	NP_689597.1			Bardet-Biedl syndrome 5											endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9						CAAAGTCTATTCTGCCAGTCC	0.333000									Bardet-Biedl syndrome				3	120					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7643069	7643069	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:7643069C>T	ENST00000572933.1	+	9	2649	c.1189C>T	c.(1189-1191)Cac>Tac	p.H397Y	DNAH2_ENST00000082259.3_Missense_Mutation_p.H479Y|DNAH2_ENST00000570791.1_Missense_Mutation_p.H479Y|DNAH2_ENST00000389173.2_Missense_Mutation_p.H397Y			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	397	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CTGTCAGTATCACTTCGCCCG	0.488000													10	5					0	0	1	0	0
TM9SF4	9777	broad.mit.edu	37	20	30753246	30753246	+	Nonstop_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:30753246G>C	ENST00000217315.5	+	18	2217	c.1877G>C	c.(1876-1878)tGa>tCa	p.*626S	TM9SF4_ENST00000398022.2_Nonstop_Mutation_p.*643S			Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	0						integral to membrane				central_nervous_system(2)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			AAGATAGACTGATTGGAGTGG	0.537000													26	40					0	0	1	0	0
LMBR1L	55716	broad.mit.edu	37	12	49498238	49498238	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:49498238G>A	ENST00000267102.8	-	5	770	c.428C>T	c.(427-429)tCc>tTc	p.S143F	LMBR1L_ENST00000553204.1_Intron|LMBR1L_ENST00000395141.4_Missense_Mutation_p.S138F|LMBR1L_ENST00000547382.1_Missense_Mutation_p.S143F	NM_018113.2	NP_060583.2	Q6UX01	LMBRL_HUMAN	limb development membrane protein 1-like	143					endocytosis	integral to membrane|plasma membrane	receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(5)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						TACCTTTCTGGAGCCAGCAAA	0.458000													54	132					0	0	1	0	0
SYS1	90196	broad.mit.edu	37	20	43995738	43995738	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:43995738C>T	ENST00000243918.5	+	4	745	c.454C>T	c.(454-456)Cct>Tct	p.P152S	SYS1-DBNDD2_ENST00000452133.1_Intron|SYS1_ENST00000426004.1_Intron|SYS1_ENST00000372727.1_Missense_Mutation_p.P152S|SYS1_ENST00000479779.1_3'UTR|SYS1_ENST00000414310.1_Missense_Mutation_p.P131S|SYS1-DBNDD2_ENST00000475242.1_Intron	NM_033542.3	NP_291020.1	Q8N2H4	SYS1_HUMAN	SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)	152					protein transport	Golgi membrane|integral to membrane				cervix(1)|endometrium(2)|large_intestine(2)|prostate(1)|skin(1)	7		Myeloproliferative disorder(115;0.0122)				CAACTCAGCCCCTAAATCCAA	0.577000													33	77					0	0	1	0	0
UHRF1	29128	broad.mit.edu	37	19	4911005	4911005	+	RNA	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:4911005C>T	ENST00000592666.1	+	0	684							Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains 1						cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|upper_aerodigestive_tract(2)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		AGGAGCTGTTCCACGTGGAGC	0.637000											OREG0025176	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	56	74					0	0	1	0	0
IGSF9B	22997	broad.mit.edu	37	11	133816031	133816031	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:133816031A>T	ENST00000321016.8	-	2	417	c.187T>A	c.(187-189)Ttc>Atc	p.F63I	IGSF9B_ENST00000533871.2_Missense_Mutation_p.F63I			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	63	Ig-like 1.					integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CCGAACTTGAACCACTCTACG	0.612000													13	21					0	0	1	0	0
CABP4	57010	broad.mit.edu	37	11	67223206	67223206	+	Silent	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:67223206G>T	ENST00000325656.5	+	1	389	c.312G>T	c.(310-312)ctG>ctT	p.L104L	CABP4_ENST00000438189.2_5'UTR|CABP4_ENST00000542025.2_3'UTR	NM_145200.3	NP_660201.1	P57796	CABP4_HUMAN	calcium binding protein 4	104					visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding			central_nervous_system(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(2)	11			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			CTGACTCCCTGCACGACGCTG	0.677000													3	22					2.56e-06	2.65372e-06	1	1	0
COL27A1	85301	broad.mit.edu	37	9	117062947	117062947	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:117062947C>T	ENST00000356083.3	+	51	5072	c.4681C>T	c.(4681-4683)Cgg>Tgg	p.R1561W		NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1	1561	Collagen-like 15.|Pro-rich.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						CCAGGGCCCTCGGGGGCCACC	0.622000													7	21					0	0	1	0	0
MAP3K10	4294	broad.mit.edu	37	19	40710537	40710537	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:40710537G>A	ENST00000253055.3	+	3	1297	c.1009G>A	c.(1009-1011)Gag>Aag	p.E337K		NM_002446.3	NP_002437.2	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase 10	337	Protein kinase.				activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						CCGCCTCCTGGAGGGTGAGCC	0.652000													11	22					0	0	1	0	0
CXADR	1525	broad.mit.edu	37	21	18933792	18933792	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:18933792C>T	ENST00000284878.7	+	6	1579	c.831C>T	c.(829-831)atC>atT	p.I277I	CXADR_ENST00000306618.10_Silent_p.I236I|CXADR_ENST00000400165.1_Intron|CXADR_ENST00000400166.1_Intron|CXADR_ENST00000400169.1_Silent_p.I277I|CXADR_ENST00000356275.6_Intron	NM_001338.4	NP_001329.1	P78310	CXAR_HUMAN	coxsackie virus and adenovirus receptor	277					blood coagulation|cell adhesion|interspecies interaction between organisms|leukocyte migration|regulation of immune response	adherens junction|basolateral plasma membrane|extracellular region|integral to plasma membrane|nucleus|tight junction	receptor activity			endometrium(2)|large_intestine(5)|lung(1)|ovary(1)|prostate(2)	11				Epithelial(23;0.000206)|all cancers(11;0.000302)|OV - Ovarian serous cystadenocarcinoma(11;0.0194)|Lung(58;0.0233)|COAD - Colon adenocarcinoma(22;0.0389)|Colorectal(24;0.0483)|LUSC - Lung squamous cell carcinoma(23;0.0782)		ATCACGATATCAGGTAATTAA	0.363000													16	25					0	0	1	0	0
GDA	9615	broad.mit.edu	37	9	74838100	74838100	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:74838100G>A	ENST00000358399.3	+	7	764	c.671G>A	c.(670-672)gGt>gAt	p.G224D	GDA_ENST00000376989.3_Intron|GDA_ENST00000376986.1_Intron|GDA_ENST00000477618.1_3'UTR|GDA_ENST00000545168.1_Missense_Mutation_p.G150D|GDA_ENST00000238018.4_Missense_Mutation_p.G224D	NM_001242505.2|NM_001242506.2|NM_004293.4	NP_001229434.1|NP_001229435.1|NP_004284.1	Q9Y2T3	GUAD_HUMAN	guanine deaminase	224					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(1)|lung(20)|ovary(2)|skin(2)|urinary_tract(1)	32		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		ACTTTGATGGGTGAACTGGGC	0.433000													8	73					0	0	1	0	0
GLRB	2743	broad.mit.edu	37	4	158091590	158091590	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:158091590G>A	ENST00000264428.4	+	10	1474	c.1204G>A	c.(1204-1206)Gag>Aag	p.E402K	GLRB_ENST00000512619.1_Silent_p.V43V|GLRB_ENST00000541722.1_Silent_p.*304*|GLRB_ENST00000509282.1_Missense_Mutation_p.E402K	NM_000824.4	NP_000815.1	P48167	GLRB_HUMAN	glycine receptor, beta	402					nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(6)|skin(5)|upper_aerodigestive_tract(1)	27	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	TTAGGTTGGTGAGACCAGATG	0.308000													17	7					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43820098	43820098	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:43820098G>T	ENST00000382031.1	+	5	7172	c.7141G>T	c.(7141-7143)Gag>Tag	p.E2381*	MAP1A_ENST00000399453.1_Nonsense_Mutation_p.E2143*|MAP1A_ENST00000300231.5_Nonsense_Mutation_p.E2143*			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2143						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GCCAGAAACTGAGGCACATGT	0.592000													19	87					2.00529e-23	2.18833e-23	1	1	0
PRKCZ	5590	broad.mit.edu	37	1	2105377	2105377	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:2105377G>C	ENST00000400921.2	+	11	1461	c.778G>C	c.(778-780)Gag>Cag	p.E260Q	PRKCZ_ENST00000479263.1_3'UTR|PRKCZ_ENST00000400920.1_Missense_Mutation_p.E260Q	NM_001033581.1	NP_001028753.1	Q05513	KPCZ_HUMAN	protein kinase C, zeta	443	Protein kinase.				anti-apoptosis|intracellular signal transduction|negative regulation of insulin receptor signaling pathway|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein complex assembly|peptidyl-serine phosphorylation|platelet activation	endosome	ATP binding|protein kinase C activity|zinc ion binding			breast(2)|central_nervous_system(4)|endometrium(1)|large_intestine(5)|lung(5)|stomach(1)	18	all_cancers(77;0.000177)|all_epithelial(69;6.41e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.96e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.3e-23)|GBM - Glioblastoma multiforme(42;2.85e-08)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00294)|BRCA - Breast invasive adenocarcinoma(365;0.00493)|STAD - Stomach adenocarcinoma(132;0.00669)|KIRC - Kidney renal clear cell carcinoma(229;0.0411)|Lung(427;0.213)		CCTCATGTTTGAGATGATGGC	0.627000											OREG0013007	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	51	84					0	0	1	0	0
TBC1D12	23232	broad.mit.edu	37	10	96162370	96162370	+	Translation_Start_Site	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:96162370G>A	ENST00000225235.4	+	0	110					NM_015188.1	NP_056003.1	O60347	TBC12_HUMAN	TBC1 domain family, member 12							intracellular	Rab GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	20		Colorectal(252;0.0429)				CCCACCCCCAGATGGTGGGTC	0.697000													11	21					0	0	1	0	0
ASIC4	55515	broad.mit.edu	37	2	220400035	220400035	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:220400035G>C	ENST00000358078.4	+	6	1613	c.1599G>C	c.(1597-1599)gaG>gaC	p.E533D	ASIC4_ENST00000347842.3_Missense_Mutation_p.E514D			Q96FT7	ACCN4_HUMAN	acid-sensing (proton-gated) ion channel family member 4	514						integral to plasma membrane	sodium channel activity|sodium ion transmembrane transporter activity										ACCGCAACGAGACCTACATAC	0.582000													9	9					0	0	1	0	0
COL28A1	340267	broad.mit.edu	37	7	7421178	7421178	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:7421178C>T	ENST00000399429.3	-	28	2342	c.2202G>A	c.(2200-2202)caG>caA	p.Q734Q		NM_001037763.2	NP_001032852.2	Q2UY09	COSA1_HUMAN	collagen, type XXVIII, alpha 1	734	Collagen-like 6.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	42		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		CACTTACCTTCTGGCCTGGGA	0.458000													40	79					0	0	1	0	0
CAMTA1	23261	broad.mit.edu	37	1	7724825	7724825	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:7724825G>A	ENST00000303635.7	+	9	2425	c.2218G>A	c.(2218-2220)Gtg>Atg	p.V740M	CAMTA1_ENST00000439411.2_Missense_Mutation_p.V740M	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	740					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CCCGGGCAACGTGGTGCAGGG	0.647000			T	WWTR1	epitheliod hemangioendothelioma								36	56					0	0	1	0	0
SEPT11	55752	broad.mit.edu	37	4	77917662	77917662	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:77917662C>G	ENST00000264893.6	+	2	313	c.112C>G	c.(112-114)Caa>Gaa	p.Q38E	SEPT11_ENST00000512575.1_Intron|SEPT11_ENST00000502584.1_Missense_Mutation_p.Q38E|SEPT11_ENST00000505788.1_Missense_Mutation_p.Q38E|SEPT11_ENST00000541121.1_Missense_Mutation_p.Q48E|SEPT11_ENST00000510515.1_Missense_Mutation_p.Q48E	NM_018243.2	NP_060713.1	Q9NVA2	SEP11_HUMAN	septin 11	38					cell cycle|cell division|protein heterooligomerization	axon|cell junction|dendritic spine|septin complex|stress fiber|synapse	GTP binding|protein binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(1)|skin(1)|stomach(1)	11						GTCTACTTCTCAAGGATTCTG	0.438000													10	60					0	0	1	0	0
BTNL8	79908	broad.mit.edu	37	5	180338519	180338519	+	Missense_Mutation	SNP	T	T	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:180338519T>G	ENST00000231229.4	+	3	812	c.578T>G	c.(577-579)aTc>aGc	p.I193S	BTNL8_ENST00000533815.2_Missense_Mutation_p.I9S|BTNL8_ENST00000400707.3_Missense_Mutation_p.I68S|BTNL8_ENST00000505126.1_De_novo_Start_InFrame|BTNL8_ENST00000340184.4_Missense_Mutation_p.I193S|BTNL8_ENST00000508408.1_Missense_Mutation_p.I193S|BTNL8_ENST00000511704.1_Missense_Mutation_p.I77S	NM_001159708.1|NM_024850.2	NP_001153180.1|NP_079126.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8	193	Ig-like V-type 2.					integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GATGTGGAGATCTCTCTGACC	0.552000													31	36					0	0	1	0	0
BTAF1	9044	broad.mit.edu	37	10	93778679	93778679	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:93778679C>T	ENST00000265990.6	+	34	5158	c.4850C>T	c.(4849-4851)tCa>tTa	p.S1617L	BTAF1_ENST00000544642.1_Missense_Mutation_p.S445L	NM_003972.2	NP_003963.1	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa	1617					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity	p.S1617*(1)		central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(2)|urinary_tract(6)	59		Colorectal(252;0.0846)				CCTAAGCTCTCAGCTTTGAAA	0.353000													13	75					0	0	1	0	0
ADGRG1	9289	broad.mit.edu	37	16	57693505	57693505	+	Silent	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:57693505C>G	ENST00000562631.1	+	11	1999	c.1467C>G	c.(1465-1467)ctC>ctG	p.L489L	GPR56_ENST00000388812.4_Silent_p.L495L|GPR56_ENST00000379694.4_Silent_p.L325L|GPR56_ENST00000388813.5_Silent_p.L489L|GPR56_ENST00000544297.1_Silent_p.L314L|GPR56_ENST00000540164.2_Silent_p.L489L|GPR56_ENST00000379696.3_Silent_p.L495L|GPR56_ENST00000568909.1_Silent_p.L495L|GPR56_ENST00000456916.1_Silent_p.L495L|GPR56_ENST00000562558.1_Silent_p.L489L|GPR56_ENST00000538815.1_Silent_p.L489L|GPR56_ENST00000567835.1_Silent_p.L495L|GPR56_ENST00000568908.1_Silent_p.L489L			Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56	495					brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity			kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)	15						GGATGGGCCTCGAGGGGTACA	0.622000													27	75					0	0	1	0	0
TYR	7299	broad.mit.edu	37	11	88924428	88924428	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:88924428C>T	ENST00000263321.5	+	2	1380	c.878C>T	c.(877-879)cCc>cTc	p.P293L	TYR_ENST00000526139.1_3'UTR	NM_000372.4	NP_000363.1	P14679	TYRO_HUMAN	tyrosinase	293					eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	48		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	AATGGAACGCCCGAGGGACCT	0.473000													34	79					0	0	1	0	0
MOV10L1	54456	broad.mit.edu	37	22	50530602	50530602	+	Silent	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr22:50530602G>C	ENST00000262794.5	+	2	353	c.270G>C	c.(268-270)ctG>ctC	p.L90L	MOV10L1_ENST00000395843.1_5'UTR|MOV10L1_ENST00000545383.1_Silent_p.L90L|MOV10L1_ENST00000395858.3_Silent_p.L90L|MOV10L1_ENST00000475190.1_3'UTR|MOV10L1_ENST00000540615.1_Silent_p.L70L	NM_018995.2	NP_061868.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)	90					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		CCAATGGACTGAAAGCAATCA	0.418000													29	13					0	0	1	0	0
METTL20	254013	broad.mit.edu	37	12	31820829	31820829	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:31820829C>T	ENST00000357721.3	+	4	909	c.694C>T	c.(694-696)Cac>Tac	p.H232Y	METTL20_ENST00000538463.1_Missense_Mutation_p.H232Y|METTL20_ENST00000395763.3_Missense_Mutation_p.H232Y|METTL20_ENST00000538391.1_3'UTR|METTL20_ENST00000412352.2_Missense_Mutation_p.H232Y	NM_001135863.1	NP_001129335.1	Q8IXQ9	MET20_HUMAN	methyltransferase like 20	232						cytoplasm	protein methyltransferase activity			lung(2)|stomach(1)	3						CATTCAGCATCACCTGCACAA	0.488000													30	59					0	0	1	0	0
ZNF232	7775	broad.mit.edu	37	17	5009120	5009120	+	Nonstop_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:5009120C>G	ENST00000250076.3	-	5	1988	c.1334G>C	c.(1333-1335)tGa>tCa	p.*445S	ZNF232_ENST00000575898.1_Nonstop_Mutation_p.*436S	NM_014519.2	NP_055334.2	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	0					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(1)|large_intestine(2)|liver(1)|lung(4)|ovary(1)|prostate(2)	11						CCCTTCAATTCAATGGGAAGG	0.403000													36	22					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104044296	104044296	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:104044296G>A	ENST00000388887.2	+	11	1401	c.1197G>A	c.(1195-1197)ctG>ctA	p.L399L		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	399	FAS1 1.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						CCTGGCCACTGAGTAAGCTGG	0.448000													14	37					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111117923	111117923	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr13:111117923C>T	ENST00000360467.5	+	25	2254	c.1948C>T	c.(1948-1950)Cct>Tct	p.P650S		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	650	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CCTGGGCCCTCCTGGCCCCGC	0.587000													9	18					0	0	1	0	0
FAM154A	158297	broad.mit.edu	37	9	18928110	18928110	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:18928110G>A	ENST00000380534.4	-	4	1644	c.1365C>T	c.(1363-1365)agC>agT	p.S455S	FAM154A_ENST00000542071.1_Silent_p.S263S|FAM154A_ENST00000380530.1_3'UTR	NM_153707.2	NP_714918.2	Q8IYX7	F154A_HUMAN	family with sequence similarity 154, member A	455										breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(13)|pancreas(1)|prostate(1)|skin(1)	26				GBM - Glioblastoma multiforme(50;6.53e-16)		CAGAAAGATGGCTGCTCTGCT	0.433000													51	44					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	33987121	33987121	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:33987121G>A	ENST00000373381.4	-	68	10715	c.10539C>T	c.(10537-10539)ttC>ttT	p.F3513F		NM_001281956.1|NM_052896.3	NP_001268885.1|NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3369						integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CTTGGTAGATGAAGGTGGCTC	0.577000													27	48					0	0	1	0	0
ANKDD1A	348094	broad.mit.edu	37	15	65209672	65209672	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:65209672G>A	ENST00000380230.3	+	3	255	c.226G>A	c.(226-228)Gag>Aag	p.E76K	ANKDD1A_ENST00000357698.3_Missense_Mutation_p.E76K|AC069368.3_ENST00000437723.1_Intron|ANKDD1A_ENST00000491145.1_3'UTR|ANKDD1A_ENST00000319580.8_Intron|ANKDD1A_ENST00000496660.1_Intron|ANKDD1A_ENST00000395720.1_Missense_Mutation_p.E76K	NM_182703.3	NP_874362.3	Q495B1	AKD1A_HUMAN	ankyrin repeat and death domain containing 1A	76					signal transduction					NS(1)|endometrium(1)|large_intestine(10)|liver(2)|lung(4)|ovary(1)|prostate(2)	21						TGCTGTGGACGAGGAGGATGC	0.657000													2	3					0	0	1	0	0
CNNM2	54805	broad.mit.edu	37	10	104814140	104814140	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:104814140C>G	ENST00000369878.4	+	3	2008	c.1820C>G	c.(1819-1821)tCt>tGt	p.S607C	CNNM2_ENST00000433628.2_Missense_Mutation_p.S607C	NM_017649.4	NP_060119.3	Q9H8M5	CNNM2_HUMAN	cyclin M2						ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|urinary_tract(1)	19		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CAAGATTTTTCTGCCTTTAAG	0.433000											OREG0020489	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	15					0	0	1	0	0
ZNF232	7775	broad.mit.edu	37	17	5009367	5009367	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:5009367C>G	ENST00000250076.3	-	5	1741	c.1087G>C	c.(1087-1089)Gaa>Caa	p.E363Q	ZNF232_ENST00000575898.1_Missense_Mutation_p.E354Q|ZNF232_ENST00000416429.2_3'UTR	NM_014519.2	NP_055334.2	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	336					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(1)|large_intestine(2)|liver(1)|lung(4)|ovary(1)|prostate(2)	11						TTCCCACATTCATTACATTCG	0.463000													19	26					0	0	1	0	0
MRPL19	9801	broad.mit.edu	37	2	75879657	75879657	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:75879657C>G	ENST00000393909.2	+	4	374	c.349C>G	c.(349-351)Ctt>Gtt	p.L117V	MRPL19_ENST00000409374.1_Missense_Mutation_p.L117V|MRPL19_ENST00000358788.6_Missense_Mutation_p.L117V	NM_014763.3	NP_055578.2	P49406	RM19_HUMAN	mitochondrial ribosomal protein L19	117					translation	mitochondrion|nuclear membrane|ribosome	structural constituent of ribosome			kidney(1)|large_intestine(1)|lung(6)	8						AGGAAGTATTCTTCGTGTTAC	0.383000													32	72					0	0	1	0	0
MUC3A	4584	broad.mit.edu	37	7	100552667	100552667	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:100552667C>T	ENST00000319509.7	+	1	1418	c.1418C>T	c.(1417-1419)tCa>tTa	p.S473L						mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						ACTAGGACTTCAGAGACACCA	0.557000													76	170					0	0	1	0	0
ERG	2078	broad.mit.edu	37	21	39817505	39817505	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:39817505C>G	ENST00000442448.1	-	4	350	c.79G>C	c.(79-81)Gag>Cag	p.E27Q	ERG_ENST00000288319.7_Missense_Mutation_p.E20Q|ERG_ENST00000429727.2_Missense_Mutation_p.E20Q|ERG_ENST00000417133.2_Missense_Mutation_p.E27Q|ERG_ENST00000398907.1_Missense_Mutation_p.E20Q|ERG_ENST00000453032.2_Intron|ERG_ENST00000398910.1_Missense_Mutation_p.E27Q|ERG_ENST00000398919.2_Missense_Mutation_p.E27Q|ERG_ENST00000398905.1_Missense_Mutation_p.E20Q|ERG_ENST00000398911.1_Missense_Mutation_p.E27Q|ERG_ENST00000398897.1_Intron	NM_004449.4	NP_004440.1	P11308	ERG_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog	27					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		EWSR1/ERG(178)|NDRG1/ERG(5)|TMPRSS2/ERG(3582)|FUS/ERG(167)|SLC45A3/ERG(50)	lung(2)|ovary(1)|skin(1)	4		Prostate(19;3.6e-06)				TAGGCACACTCAAACAACGAC	0.502000			T	"""EWSR1, TMPRSS2, ELF4, FUS, HERPUD1, NDRG1"""	"""Ewing sarcoma, prostate, AML"""								18	40					0	0	1	0	0
JPH3	57338	broad.mit.edu	37	16	87677915	87677915	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:87677915G>A	ENST00000284262.2	+	2	676	c.434G>A	c.(433-435)cGg>cAg	p.R145Q		NM_020655.2	NP_065706.2	Q8WXH2	JPH3_HUMAN	junctophilin 3	145					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(80;0.0287)		TACGGCGTCCGGCAGAGCGTC	0.677000													39	38					0	0	1	0	0
CDH1	999	broad.mit.edu	37	16	68844139	68844139	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:68844139G>C	ENST00000261769.5	+	6	918	c.727G>C	c.(727-729)Gag>Cag	p.E243Q	CDH1_ENST00000422392.2_Missense_Mutation_p.E243Q|CDH1_ENST00000562836.1_3'UTR	NM_004360.3	NP_004351.1	P12830	CADH1_HUMAN	cadherin 1, type 1, E-cadherin (epithelial)	243	Cadherin 1.				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding	p.?(4)|p.E243*(2)|p.E243K(1)		NS(6)|biliary_tract(8)|breast(161)|central_nervous_system(4)|endometrium(9)|kidney(4)|large_intestine(13)|lung(13)|oesophagus(3)|ovary(2)|prostate(3)|soft_tissue(2)|stomach(76)|thyroid(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	311		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		GAATGCAGTTGAGGATCCAAT	0.493000			"""Mis, N, F, S"""		"""lobular breast, gastric"""	gastric			Hereditary Diffuse Gastric Cancer				63	89					0	0	1	0	0
TMEM38B	55151	broad.mit.edu	37	9	108457020	108457020	+	Missense_Mutation	SNP	C	C	G	rs11542697		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:108457020C>G	ENST00000374692.3	+	1	196	c.79C>G	c.(79-81)Cta>Gta	p.L27V		NM_018112.1	NP_060582.1	Q9NVV0	TM38B_HUMAN	transmembrane protein 38B	27						integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	13						CGCGCACTATCTAGTGTCAGT	0.622000													32	71					0	0	1	0	0
FNBP1	23048	broad.mit.edu	37	9	132658267	132658267	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:132658267C>T	ENST00000420781.1	-	16	1887	c.1669G>A	c.(1669-1671)Gaa>Aaa	p.E557K	FNBP1_ENST00000355681.3_Missense_Mutation_p.E537K|FNBP1_ENST00000443566.2_Missense_Mutation_p.E194K|FNBP1_ENST00000446176.2_Missense_Mutation_p.E566K			Q96RU3	FNBP1_HUMAN	formin binding protein 1	566	Interaction with ARHGAP17, DAAM1, DIAPH1 and DIAPH2.|Interaction with DNM1 and DNM3.|Interaction with DNM2 and WASL.|Interaction with FASLG.|Interaction with PDE6G (By similarity).|Required for interaction with TNKS.|Required for self-association and induction of membrane tubulation.|SH3.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|lysosome|plasma membrane	identical protein binding|lipid binding						Ovarian(14;0.000536)		GBM - Glioblastoma multiforme(294;0.0378)		ATCGTTCCTTCATTCTGACCT	0.448000			T	MLL	AML								23	61					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123419015	123419015	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:123419015G>C	ENST00000360772.3	-	19	3678	c.3300C>G	c.(3298-3300)ttC>ttG	p.F1100L	MYLK_ENST00000346322.5_Missense_Mutation_p.F1031L|MYLK_ENST00000359169.1_Missense_Mutation_p.F1100L|MYLK_ENST00000360304.3_Missense_Mutation_p.F1100L|MYLK_ENST00000475616.1_Missense_Mutation_p.F1100L			Q15746	MYLK_HUMAN	myosin light chain kinase	1100	Actin-binding (calcium/calmodulin- insensitive) (By similarity).|Ig-like C2-type 7.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GCTTCTGCTTGAAGGCTGGGG	0.532000													36	62					0	0	1	0	0
CACTIN	58509	broad.mit.edu	37	19	3620192	3620192	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:3620192C>A	ENST00000429344.2	-	4	869	c.817G>T	c.(817-819)Gag>Tag	p.E273*	CACTIN_ENST00000221899.3_Nonsense_Mutation_p.E205*|CACTIN_ENST00000248420.5_Nonsense_Mutation_p.E273*	NM_001080543.1	NP_001074012.1			cactin, spliceosome C complex subunit																		TGCTCTGCCTCCTTCTCGCGC	0.672000													7	20					1.58986e-06	1.65125e-06	1	1	0
F13A1	2162	broad.mit.edu	37	6	6224981	6224981	+	Missense_Mutation	SNP	C	C	T	rs139164988		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:6224981C>T	ENST00000264870.3	-	7	1176	c.911G>A	c.(910-912)cGg>cAg	p.R304Q		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	304					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	CTCAGAGCTCCGGTATTCCAA	0.463000													38	73					0	0	1	0	0
KIAA0947	23379	broad.mit.edu	37	5	5465303	5465303	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:5465303G>C	ENST00000296564.7	+	13	6078	c.5856G>C	c.(5854-5856)gaG>gaC	p.E1952D		NM_015325.2	NP_056140.1	Q9Y2F5	K0947_HUMAN	KIAA0947	1952										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)	35						GAGATCAAGAGAAGGAAGTTG	0.368000													2	6					0	0	1	0	0
ZNF232	7775	broad.mit.edu	37	17	5009220	5009220	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:5009220C>G	ENST00000250076.3	-	5	1888	c.1234G>C	c.(1234-1236)Gag>Cag	p.E412Q	ZNF232_ENST00000575898.1_Missense_Mutation_p.E403Q	NM_014519.2	NP_055334.2	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	385					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(1)|large_intestine(2)|liver(1)|lung(4)|ovary(1)|prostate(2)	11						AAAGGTTTCTCTCCACTGTGA	0.443000													25	20					0	0	1	0	0
PTPRG	5793	broad.mit.edu	37	3	62189597	62189597	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:62189597G>C	ENST00000474889.1	+	12	2505	c.2128G>C	c.(2128-2130)Gac>Cac	p.D710H	PTPRG_ENST00000295874.10_Missense_Mutation_p.D710H	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	710					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		ATTTTCTGAAGACAGCAGATT	0.512000													20	54					0	0	1	0	0
PRMT2	3275	broad.mit.edu	37	21	48071881	48071881	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:48071881C>G	ENST00000334494.4	+	7	985	c.818C>G	c.(817-819)tCa>tGa	p.S273*	PRMT2_ENST00000451211.2_Intron|PRMT2_ENST00000397638.2_Intron|PRMT2_ENST00000440086.1_Intron|PRMT2_ENST00000355680.3_Intron|PRMT2_ENST00000291705.6_Intron|PRMT2_ENST00000397637.1_Intron|PRMT2_ENST00000458387.2_Intron	NM_001242865.1	NP_001229794.1	P55345	ANM2_HUMAN	protein arginine methyltransferase 2	0	Interaction with ESR1.				developmental cell growth|induction of apoptosis|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of androgen receptor signaling pathway	cytosol|nucleus	androgen receptor binding|estrogen receptor binding|histone-arginine N-methyltransferase activity|peroxisome proliferator activated receptor binding|progesterone receptor binding|protein homodimerization activity|retinoic acid receptor binding|signal transducer activity|thyroid hormone receptor binding|transcription coactivator activity			NS(1)|breast(3)|endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	16	Breast(49;0.247)	Lung NSC(3;0.245)		Epithelial(3;1.03e-07)|OV - Ovarian serous cystadenocarcinoma(3;4.68e-07)|all cancers(3;7.48e-07)|Colorectal(79;0.167)|Lung(125;0.203)|LUSC - Lung squamous cell carcinoma(216;0.23)|READ - Rectum adenocarcinoma(84;0.248)		CCTCAGCCCTCAGGCCTTCAT	0.567000													17	52					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151851456	151851456	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:151851456C>G	ENST00000355193.2	-	48	12424	c.12206G>C	c.(12205-12207)gGg>gCg	p.G4069A	KMT2C_ENST00000262189.6_Missense_Mutation_p.G4012A|KMT2C_ENST00000485241.1_5'UTR					lysine (K)-specific methyltransferase 2C																		CACTTCTACCCCAACCACACT	0.498000													37	121					0	0	1	0	0
ZNF532	55205	broad.mit.edu	37	18	56587297	56587297	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr18:56587297C>T	ENST00000336078.4	+	4	2554	c.1778C>T	c.(1777-1779)cCa>cTa	p.P593L	ZNF532_ENST00000591230.1_Missense_Mutation_p.P593L|ZNF532_ENST00000591083.1_Missense_Mutation_p.P593L|ZNF532_ENST00000591808.1_Missense_Mutation_p.P593L|ZNF532_ENST00000589288.1_Missense_Mutation_p.P593L	NM_018181.4	NP_060651.2	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	593					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(14)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(4)|urinary_tract(1)	52						AGTGTCAATCCAGTCCCTGTT	0.557000													10	26					0	0	1	0	0
KIAA1244	57221	broad.mit.edu	37	6	138483238	138483238	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:138483238G>A	ENST00000251691.4	+	1	181	c.15G>A	c.(13-15)ctG>ctA	p.L5L		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	5					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		AAGAAATCCTGAGGAAGCTGC	0.697000													3	22					0	0	1	0	0
SLC28A3	64078	broad.mit.edu	37	9	86955491	86955491	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:86955491G>A	ENST00000376238.4	-	1	107	c.58C>T	c.(58-60)Cag>Tag	p.Q20*	SLC28A3_ENST00000537648.1_5'UTR|SLC28A3_ENST00000495823.1_5'UTR	NM_001199633.1|NM_022127.2	NP_001186562.1|NP_071410.1	Q9HAS3	S28A3_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 3	20					nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			endometrium(2)|large_intestine(6)|lung(17)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31						CTGCTCACCTGGAAGCCCACG	0.532000													20	31					0	0	1	0	0
PLXNB2	23654	broad.mit.edu	37	22	50726223	50726223	+	Splice_Site	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr22:50726223C>A	ENST00000449103.1	-	7	1622		c.e7-1		PLXNB2_ENST00000359337.4_Splice_Site			O15031	PLXB2_HUMAN	plexin B2						regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CCGGGTGCATCTGCAGGCGCA	0.706000													8	6					3.86212e-05	3.96531e-05	1	1	0
KCNH4	23415	broad.mit.edu	37	17	40321612	40321612	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:40321612G>A	ENST00000264661.3	-	9	1805	c.1473C>T	c.(1471-1473)cgC>cgT	p.R491R	KCNH4_ENST00000607371.1_Silent_p.R491R	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	491					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GGTCCTTCATGCGGCTGTGGT	0.637000													24	57					0	0	1	0	0
ASB14	142686	broad.mit.edu	37	3	57312522	57312522	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:57312522C>T	ENST00000487349.1	-	8	1434	c.1314G>A	c.(1312-1314)agG>agA	p.R438R	ASB14_ENST00000389601.3_Silent_p.R438R	NM_001142733.2|NM_130387.5	NP_001136205.2|NP_569058.1	A6NK59	ASB14_HUMAN	ankyrin repeat and SOCS box containing 14	438					intracellular signal transduction					central_nervous_system(1)|large_intestine(1)|lung(1)|skin(2)	5				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		TCAGCAGCATCCTGAGCATGA	0.453000													108	152					0	0	1	0	0
ATP13A3	79572	broad.mit.edu	37	3	194159590	194159590	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:194159590C>G	ENST00000439040.1	-	17	2613	c.1822G>C	c.(1822-1824)Gaa>Caa	p.E608Q	ATP13A3_ENST00000256031.4_Missense_Mutation_p.E608Q			Q9H7F0	AT133_HUMAN	ATPase type 13A3	608					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	24	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		CTCACCATTTCTTGGTTTCCT	0.348000													40	94					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90124866	90124866	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:90124866G>A	ENST00000405460.2	+	77	16570	c.16474G>A	c.(16474-16476)Gat>Aat	p.D5492N	GPR98_ENST00000425867.2_Missense_Mutation_p.D1153N	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	5492					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTTAGAAAGTGATGAATCTCA	0.433000													35	34					0	0	1	0	0
RUVBL1	8607	broad.mit.edu	37	3	127800229	127800229	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:127800229G>A	ENST00000322623.5	-	11	1334	c.1235C>T	c.(1234-1236)cCg>cTg	p.P412L	RUVBL1_ENST00000417360.1_Silent_p.P381P|RUVBL1_ENST00000464873.1_Intron	NM_003707.2	NP_003698.1	Q9Y265	RUVB1_HUMAN	RuvB-like AAA ATPase 1	412					cell division|CenH3-containing nucleosome assembly at centromere|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|mitosis|regulation of growth|regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription, DNA-dependent	Golgi apparatus|Ino80 complex|membrane|microtubule organizing center|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|DNA helicase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26				GBM - Glioblastoma multiforme(114;0.181)		CAAGTTGGCCGGGGTCAGCAG	0.537000													3	48					0	0	1	0	0
CABIN1	23523	broad.mit.edu	37	22	24456601	24456601	+	Silent	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr22:24456601C>A	ENST00000398319.2	+	12	1999	c.1614C>A	c.(1612-1614)atC>atA	p.I538I	CABIN1_ENST00000405822.2_Silent_p.I488I|CABIN1_ENST00000263119.5_Silent_p.I538I	NM_001199281.1	NP_001186210.1	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	538					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(13)|liver(1)|lung(18)|ovary(5)|pancreas(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						ACAAGCACATCAAGGTTAGGG	0.617000													3	71					1	1	1	1	0
PTPRT	11122	broad.mit.edu	37	20	41419965	41419965	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:41419965G>A	ENST00000373198.4	-	3	591	c.356C>T	c.(355-357)gCc>gTc	p.A119V	PTPRT_ENST00000373201.1_Missense_Mutation_p.A119V|PTPRT_ENST00000373187.1_Missense_Mutation_p.A119V|PTPRT_ENST00000356100.2_Missense_Mutation_p.A119V|PTPRT_ENST00000373190.1_Missense_Mutation_p.A119V|PTPRT_ENST00000373184.1_Missense_Mutation_p.A119V|PTPRT_ENST00000373193.3_Missense_Mutation_p.A119V	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T		MAM.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GACGTTCAAGGCCCCTGGGCT	0.597000													34	44					0	0	1	0	0
OR10X1	128367	broad.mit.edu	37	1	158549434	158549434	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:158549434C>T	ENST00000368150.1	-	1	255	c.256G>A	c.(256-258)Gag>Aag	p.E86K		NM_001004477.1	NP_001004477.1	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X, member 1 (gene/pseudogene)	86					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(22)|ovary(2)|skin(2)|urinary_tract(1)	37	all_hematologic(112;0.0378)					TAGCAGGTCTCAGAGAAGGAG	0.498000													18	42					0	0	1	0	0
CYFIP1	23191	broad.mit.edu	37	15	22925788	22925788	+	Silent	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:22925788G>T	ENST00000313077.7	+	2	131	c.6G>T	c.(4-6)gcG>gcT	p.A2A	CYFIP1_ENST00000560848.1_Silent_p.A2A	NM_014608.2	NP_055423.1	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1	2					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(1)|lung(14)|ovary(4)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	40		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		CCAGGATGGCGGCCCAGGTGA	0.647000													10	9					0.000151284	0.00015415	1	1	0
ATAD5	79915	broad.mit.edu	37	17	29196272	29196272	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:29196272C>T	ENST00000321990.4	+	13	3698	c.3320C>T	c.(3319-3321)tCg>tTg	p.S1107L		NM_024857.3	NP_079133.3	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1107					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(18)|lung(13)|ovary(3)|pancreas(1)	51		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				TCAGATTTCTCGGGTGGCATA	0.393000													21	39					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87174162	87174162	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:87174162T>C	ENST00000265724.3	-	17	2458	c.2041A>G	c.(2041-2043)Aag>Gag	p.K681E	ABCB1_ENST00000543898.1_Missense_Mutation_p.K617E	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	681					G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GTACTAAGCTTTCTGTCTTGG	0.433000													10	100					0	0	1	0	0
PIWIL3	440822	broad.mit.edu	37	22	25150040	25150040	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr22:25150040C>G	ENST00000332271.5	-	8	1334	c.918G>C	c.(916-918)caG>caC	p.Q306H	PIWIL3_ENST00000532537.2_5'UTR|PIWIL3_ENST00000527701.1_Missense_Mutation_p.Q197H|PIWIL3_ENST00000533313.1_Missense_Mutation_p.Q197H	NM_001008496.3|NM_001255975.1	NP_001008496.2|NP_001242904.1	Q7Z3Z3	PIWL3_HUMAN	piwi-like RNA-mediated gene silencing 3	306	PAZ.				cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(15)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						TGTTTCCTGTCTGGGCCTGGG	0.388000													52	296					0	0	1	0	0
FGF17	8822	broad.mit.edu	37	8	21903643	21903643	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:21903643C>G	ENST00000359441.3	+	3	594	c.91C>G	c.(91-93)Cct>Gct	p.P31A	FGF17_ENST00000518533.1_Intron|FGF17_ENST00000521709.1_Intron	NM_003867.2	NP_003858.1	O60258	FGF17_HUMAN	fibroblast growth factor 17	31					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|nervous system development	extracellular space	growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)	8				Colorectal(74;8.48e-05)|READ - Rectum adenocarcinoma(5;0.0276)|COAD - Colon adenocarcinoma(73;0.0618)		TCACCCGTCTCCTAATTTTAA	0.557000													30	22					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87180046	87180046	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:87180046C>G	ENST00000265724.3	-	11	1525	c.1108G>C	c.(1108-1110)Gat>Cat	p.D370H	ABCB1_ENST00000543898.1_Missense_Mutation_p.D306H	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	370					G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	CTTACATTATCAATTATCTTG	0.373000													13	37					0	0	1	0	0
ZNF92	168374	broad.mit.edu	37	7	64863789	64863789	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:64863789G>A	ENST00000328747.7	+	4	961	c.762G>A	c.(760-762)gaG>gaA	p.E254E	ZNF92_ENST00000357512.2_Silent_p.E222E|ZNF92_ENST00000431504.1_Silent_p.E178E|ZNF92_ENST00000450302.2_Silent_p.E185E	NM_152626.2	NP_689839.1	Q03936	ZNF92_HUMAN	zinc finger protein 92	254						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(3)|lung(4)|pancreas(1)|skin(1)|stomach(1)	13		Lung NSC(55;0.159)				ATACTGGAGAGAAACCCTACA	0.353000													4	105					0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23544724	23544724	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:23544724T>C	ENST00000300619.7	-	4	1262	c.1057A>G	c.(1057-1059)Aaa>Gaa	p.K353E	ZNF91_ENST00000397082.2_Missense_Mutation_p.K321E|ZNF91_ENST00000599743.1_Intron	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	353						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.K353E(1)					all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				CCACATTCTTTACATTTGTAG	0.373000													3	99					0	0	1	0	0
THNSL2	55258	broad.mit.edu	37	2	88485580	88485580	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:88485580C>T	ENST00000324166.5	+	8	3084	c.1393C>T	c.(1393-1395)Cgg>Tgg	p.R465W	THNSL2_ENST00000377254.3_3'UTR|THNSL2_ENST00000449349.1_3'UTR|THNSL2_ENST00000496844.1_3'UTR|THNSL2_ENST00000358591.2_Missense_Mutation_p.R465W|THNSL2_ENST00000343544.4_3'UTR	NM_018271.4	NP_060741.3	Q86YJ6	THNS2_HUMAN	threonine synthase-like 2 (S. cerevisiae)	465					threonine biosynthetic process		threonine synthase activity			breast(4)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	27						GCTGATGCTTCGGGACACCAT	0.592000													3	7					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55581763	55581763	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:55581763A>T	ENST00000361849.3	-	34	6123	c.5729T>A	c.(5728-5730)cTa>cAa	p.L1910Q	PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000373957.3_Missense_Mutation_p.L762Q|PCDH15_ENST00000395445.1_Intron|PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000437009.1_Missense_Mutation_p.L1839Q|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000320301.6_Missense_Mutation_p.L1908Q|PCDH15_ENST00000395438.1_Intron|PCDH15_ENST00000395430.1_Missense_Mutation_p.L1905Q|PCDH15_ENST00000395433.1_Missense_Mutation_p.L1885Q|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000395432.2_Missense_Mutation_p.L1868Q	NM_001142763.1|NM_001142764.1|NM_001142765.1|NM_001142768.1	NP_001136235.1|NP_001136236.1|NP_001136237.1|NP_001136240.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1908					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				ATTTGTGCGTAGATAGTTTTT	0.358000										HNSCC(58;0.16)			5	63					0	0	1	0	0
JRKL	8690	broad.mit.edu	37	11	96124929	96124929	+	Silent	SNP	A	A	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:96124929A>G	ENST00000458427.1	+	1	1772	c.1116A>G	c.(1114-1116)gcA>gcG	p.A372A	JRKL_ENST00000546177.1_Intron|JRKL_ENST00000332349.4_Silent_p.A372A	NM_003772.3	NP_003763.2	Q9Y4A0	JERKL_HUMAN	jerky homolog-like (mouse)	372	DDE.				central nervous system development|regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|upper_aerodigestive_tract(1)	11		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)		BRCA - Breast invasive adenocarcinoma(274;0.148)		TAGCAATGGCATGGAACTTAG	0.408000													3	134					0	0	1	0	0
GLG1	2734	broad.mit.edu	37	16	74493622	74493622	+	Silent	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:74493622G>C	ENST00000422840.2	-	23	3101	c.3102C>G	c.(3100-3102)ctC>ctG	p.L1034L	GLG1_ENST00000447066.2_Silent_p.L1023L|GLG1_ENST00000205061.5_Silent_p.L1034L	NM_001145667.1	NP_001139139.1	Q92896	GSLG1_HUMAN	golgi glycoprotein 1	1034						Golgi membrane|integral to membrane	receptor binding			breast(2)|cervix(2)|endometrium(6)|kidney(8)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(1)	57						GGTTGACCTTGAGGCACTCCT	0.438000													12	22					0	0	1	0	0
MUC20	200958	broad.mit.edu	37	3	195451911	195451911	+	Missense_Mutation	SNP	A	A	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:195451911A>C	ENST00000320736.6	+	2	563	c.437A>C	c.(436-438)gAt>gCt	p.D146A	MUC20_ENST00000436408.1_Missense_Mutation_p.D146A|MUC20_ENST00000447234.2_Missense_Mutation_p.D146A|MUC20_ENST00000445522.2_Missense_Mutation_p.D111A			Q8N307	MUC20_HUMAN	mucin 20, cell surface associated	327			Missing.		protein homooligomerization	apical plasma membrane|basal plasma membrane|extracellular region|microvillus membrane				NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(1)	23	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)		CTTTGCACCGATGACAGCTCT	0.557000													17	343					0	0	1	0	0
UPF1	5976	broad.mit.edu	37	19	18943112	18943112	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:18943112G>C	ENST00000262803.5	+	1	366	c.94G>C	c.(94-96)Gag>Cag	p.E32Q	UPF1_ENST00000599848.1_Missense_Mutation_p.E32Q	NM_002911.3	NP_002902.2	Q92900	RENT1_HUMAN	UPF1 regulator of nonsense transcripts homolog (yeast)	32	Sufficient for interaction with RENT2.				cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|RNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40						ACAGGGCTCCGAGTTCGAGTT	0.721000													30	35					0	0	1	0	0
SYCP2L	221711	broad.mit.edu	37	6	10912908	10912908	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:10912908G>A	ENST00000283141.6	+	13	1217	c.921G>A	c.(919-921)atG>atA	p.M307I	SYCP2L_ENST00000543878.1_Missense_Mutation_p.M148I|RP11-637O19.3_ENST00000480294.1_3'UTR	NM_001040274.2	NP_001035364.2	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	307						nucleus				breast(3)|central_nervous_system(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	36	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			TCTTACAGATGAGAAAACCAG	0.343000													12	51					0	0	1	0	0
PROCA1	147011	broad.mit.edu	37	17	27030629	27030629	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:27030629T>C	ENST00000301039.2	-	4	1151	c.958A>G	c.(958-960)Agg>Ggg	p.R320G	PROCA1_ENST00000439862.3_Missense_Mutation_p.R322G	NM_152465.1	NP_689678.1	Q8NCQ7	PRCA1_HUMAN	protein interacting with cyclin A1	348			E -> K (in dbSNP:rs3744637).		lipid catabolic process		calcium ion binding|phospholipase A2 activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(7)|lung(4)|ovary(1)|urinary_tract(1)	16	Lung NSC(42;0.00431)					TTTACCTTCCTGGCTTGTGAG	0.532000													58	101					0	0	1	0	0
VGLL3	389136	broad.mit.edu	37	3	87018080	87018080	+	Silent	SNP	A	A	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:87018080A>G	ENST00000398399.2	-	3	960	c.597T>C	c.(595-597)ccT>ccC	p.P199P	VGLL3_ENST00000383698.3_Silent_p.P199P	NM_016206.2	NP_057290.2	A8MV65	VGLL3_HUMAN	vestigial like 3 (Drosophila)	199					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(11)	19	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		CAGCAGGGGGAGGGGCTGGGC	0.587000													3	153					0	0	1	0	0
DPP3	10072	broad.mit.edu	37	11	66272178	66272178	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:66272178C>T	ENST00000532677.1	+	17	2432	c.2031C>T	c.(2029-2031)ctC>ctT	p.L677L	DPP3_ENST00000541961.1_Silent_p.L658L|DPP3_ENST00000360510.2_Silent_p.L658L|DPP3_ENST00000531863.1_Silent_p.L678L|DPP3_ENST00000453114.1_Silent_p.L658L|DPP3_ENST00000530165.1_Silent_p.L628L	NM_001256670.1|NM_005700.4|NM_130443.3	NP_001243599.1|NP_005691.2|NP_569710.2	Q9NY33	DPP3_HUMAN	dipeptidyl-peptidase 3	658					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)	23						TCCTCACCCTCAGGGACACGG	0.597000													24	91					0	0	1	0	0
MRM1	79922	broad.mit.edu	37	17	34958561	34958561	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:34958561G>A	ENST00000250156.7	+	1	561	c.322G>A	c.(322-324)Gac>Aac	p.D108N	MRM1_ENST00000585770.1_5'UTR	NM_024864.3	NP_079140.2	Q6IN84	MRM1_HUMAN	mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)	108					RNA processing	mitochondrion	RNA binding|RNA methyltransferase activity			NS(1)|endometrium(1)|large_intestine(2)|lung(1)	5		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		GCAGAAACTGGACACAATGTG	0.697000													22	29					0	0	1	0	0
LOC101927060	101927060	broad.mit.edu	37	17	45127107	45127107	+	RNA	SNP	C	C	G	rs147409399	by1000genomes	TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:45127107C>G	ENST00000575173.1	-	0	418																											CCTTCGTTCACCCAAGAGCAT	0.592000													3	59					0	0	1	0	0
CABP2	51475	broad.mit.edu	37	11	67287568	67287568	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:67287568G>C	ENST00000294288.4	-	5	512	c.443C>G	c.(442-444)aCg>aGg	p.T148R	CABP2_ENST00000353903.5_Missense_Mutation_p.T91R	NM_016366.2	NP_057450.2	Q9NPB3	CABP2_HUMAN	calcium binding protein 2	148					signal transduction	Golgi apparatus|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			endometrium(2)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	9						CATGTCTGCCGTCTCTGCCAG	0.657000													16	68					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108236064	108236064	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:108236064G>C	ENST00000278616.4	+	63	9385	c.9000G>C	c.(8998-9000)caG>caC	p.Q3000H	C11orf65_ENST00000526725.1_Intron|ATM_ENST00000525178.1_3'UTR|ATM_ENST00000452508.2_Missense_Mutation_p.Q3000H|C11orf65_ENST00000525729.1_Intron	NM_000051.3	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	3000					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		ATATTGACCAGAGTTTCAACA	0.403000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			15	60					0	0	1	0	0
ZNF492	57615	broad.mit.edu	37	19	22847709	22847709	+	Missense_Mutation	SNP	T	T	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:22847709T>A	ENST00000456783.2	+	4	1482	c.1238T>A	c.(1237-1239)aTa>aAa	p.I413K		NM_020855.2	NP_065906.1	Q9P255	ZN492_HUMAN	zinc finger protein 492	413					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				ACACATAAGATAATTCATACT	0.368000													31	56					0	0	1	0	0
IFNAR1	3454	broad.mit.edu	37	21	34717650	34717650	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:34717650C>T	ENST00000270139.3	+	6	924	c.772C>T	c.(772-774)Caa>Taa	p.Q258*	IFNAR1_ENST00000416947.2_Nonsense_Mutation_p.Q189*|IFNAR1_ENST00000442357.2_Nonsense_Mutation_p.Q258*	NM_000629.2	NP_000620.2	P17181	INAR1_HUMAN	interferon (alpha, beta and omega) receptor 1	258	Fibronectin type-III 2.				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	integral to plasma membrane	type I interferon receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|skin(2)	14					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	CATGACCTTTCAAGTTCAGTG	0.378000													9	30					0	0	1	0	0
OSBP2	23762	broad.mit.edu	37	22	31289875	31289875	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr22:31289875G>T	ENST00000332585.6	+	12	2366	c.2262G>T	c.(2260-2262)atG>atT	p.M754I	OSBP2_ENST00000382310.3_Missense_Mutation_p.M705I|OSBP2_ENST00000401475.1_Missense_Mutation_p.M387I|OSBP2_ENST00000407373.1_Missense_Mutation_p.M581I|OSBP2_ENST00000446658.2_Missense_Mutation_p.M753I|OSBP2_ENST00000496575.1_3'UTR|OSBP2_ENST00000403222.3_Missense_Mutation_p.M588I|OSBP2_ENST00000437268.2_Missense_Mutation_p.M496I|OSBP2_ENST00000535268.1_Missense_Mutation_p.M298I	NM_001282739.1|NM_001282740.1|NM_001282741.1|NM_001282742.1|NM_030758.3	NP_001269668.1|NP_001269669.1|NP_001269670.1|NP_001269671.1|NP_110385.1	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2	754					lipid transport	membrane	lipid binding			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(6)|ovary(1)|skin(3)|urinary_tract(1)	19						ATGAACAAATGGAGTGCTCCA	0.582000													6	2					0.0293803	0.0297117	1	1	0
CACNA1C	775	broad.mit.edu	37	12	2788756	2788756	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:2788756G>A	ENST00000399655.1	+	42	5503	c.5238G>A	c.(5236-5238)gaG>gaA	p.E1746E	CACNA1C_ENST00000399621.1_Silent_p.E1765E|CACNA1C_ENST00000335762.5_Silent_p.E1771E|CACNA1C_ENST00000399597.1_Silent_p.E1746E|CACNA1C_ENST00000406454.3_Silent_p.E1746E|CACNA1C_ENST00000347598.4_Silent_p.E1794E|CACNA1C_ENST00000399617.1_Silent_p.E1746E|CACNA1C_ENST00000402845.3_Silent_p.E1765E|CACNA1C_ENST00000399649.1_Silent_p.E1752E|CACNA1C_ENST00000399637.1_Silent_p.E1765E|CACNA1C_ENST00000399638.1_Silent_p.E1774E|CACNA1C_ENST00000399603.1_Silent_p.E1746E|CACNA1C_ENST00000399629.1_Silent_p.E1763E|CACNA1C_ENST00000399595.1_Silent_p.E1754E|CACNA1C_ENST00000327702.7_Silent_p.E1746E|CACNA1C-AS1_ENST00000501371.1_RNA|CACNA1C_ENST00000344100.3_Silent_p.E1787E|CACNA1C_ENST00000399634.1_Silent_p.E1746E|CACNA1C_ENST00000399601.1_Silent_p.E1746E|CACNA1C_ENST00000399606.1_Silent_p.E1766E|CACNA1C_ENST00000399644.1_Silent_p.E1746E|CACNA1C_ENST00000399641.1_Silent_p.E1746E|CACNA1C_ENST00000399591.1_Silent_p.E1754E	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1794					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CATCCCACGAGAAGCTGGTGG	0.657000													11	24					0	0	1	0	0
FOLR3	2352	broad.mit.edu	37	11	71850770	71850770	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:71850770G>C	ENST00000445078.2	+	5	824	c.753G>C	c.(751-753)caG>caC	p.Q251H	FOLR3_ENST00000442948.2_Missense_Mutation_p.Q210H|FOLR3_ENST00000456237.1_Missense_Mutation_p.Q253H			P41439	FOLR3_HUMAN	folate receptor 3 (gamma)	209					folic acid transport	extracellular region|extrinsic to membrane|membrane fraction	folic acid binding|receptor activity			large_intestine(3)|lung(8)|prostate(2)	13					Folic Acid(DB00158)	GCTGCATCCAGATGTGGTTTG	0.577000													11	51					0	0	1	0	0
AUP1	550	broad.mit.edu	37	2	74754468	74754468	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:74754468C>G	ENST00000377526.3	-	10	1293	c.984G>C	c.(982-984)ttG>ttC	p.L328F		NM_181575.3	NP_853553.1	Q9Y679	AUP1_HUMAN	ancient ubiquitous protein 1	394						endoplasmic reticulum membrane|integral to membrane|nucleus	protein binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(7)	11						TAGTGATAGTCAAGTCTACAC	0.527000													11	27					0	0	1	0	0
CFLAR	8837	broad.mit.edu	37	2	202025318	202025318	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:202025318G>A	ENST00000309955.3	+	9	1472	c.957G>A	c.(955-957)caG>caA	p.Q319Q	CFLAR_ENST00000341582.6_Silent_p.Q284Q|CFLAR_ENST00000479953.2_Silent_p.Q223Q|CFLAR_ENST00000443227.1_Silent_p.Q223Q|CFLAR_ENST00000457277.1_Silent_p.Q319Q|CFLAR_ENST00000355558.4_Intron|CFLAR_ENST00000423241.2_Silent_p.Q319Q|CFLAR_ENST00000340870.5_Silent_p.Q319Q	NM_001202515.1|NM_003879.5	NP_001189444.1|NP_003870.4	O15519	CFLAR_HUMAN	CASP8 and FADD-like apoptosis regulator		Caspase.|Interaction with TRAF1 and TRAF2.|Interaction with caspase-3.|Interaction with caspase-8 subunits p18 and p10.|Not proteolytically processed and involved in apoptosis inhibition.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis		cysteine-type endopeptidase activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|stomach(1)	13						GAGGCTCCCAGAGTGTGTATG	0.537000													42	76					0	0	1	0	0
TBXAS1	6916	broad.mit.edu	37	7	139661804	139661804	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:139661804C>T	ENST00000263552.6	+	13	1447	c.909C>T	c.(907-909)gaC>gaT	p.D303D	TBXAS1_ENST00000462275.1_3'UTR|TBXAS1_ENST00000416849.2_Silent_p.D349D|TBXAS1_ENST00000448866.1_Silent_p.D302D|TBXAS1_ENST00000414508.2_Silent_p.D303D|TBXAS1_ENST00000411653.1_Silent_p.D302D|TBXAS1_ENST00000458722.1_Silent_p.D348D|TBXAS1_ENST00000436047.2_Silent_p.D303D|TBXAS1_ENST00000425687.1_Silent_p.D235D|TBXAS1_ENST00000336425.5_Silent_p.D302D	NM_001130966.2	NP_001124438	P24557	THAS_HUMAN	thromboxane A synthase 1 (platelet)	302					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					TCGTCAGAGACGTTTTCTCCT	0.562000													23	29					0	0	1	0	0
SYNGAP1	8831	broad.mit.edu	37	6	33408987	33408987	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:33408987G>T	ENST00000418600.2	+	12	2052	c.1951G>T	c.(1951-1953)Gag>Tag	p.E651*	SYNGAP1_ENST00000293748.5_Nonsense_Mutation_p.E651*|SYNGAP1_ENST00000496374.1_3'UTR|SYNGAP1_ENST00000428982.2_Nonsense_Mutation_p.E592*	NM_006772.2	NP_006763.2	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	651					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(15)|ovary(7)|pancreas(1)|stomach(1)|urinary_tract(1)	43						CTTCATGAATGAGTTTCTGGA	0.453000													45	32					2.18419e-29	2.40306e-29	1	1	0
MRPL13	28998	broad.mit.edu	37	8	121426333	121426333	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:121426333G>C	ENST00000306185.3	-	6	703	c.412C>G	c.(412-414)Ctt>Gtt	p.L138V		NM_014078.5	NP_054797.2	Q9BYD1	RM13_HUMAN	mitochondrial ribosomal protein L13	138					translation	mitochondrial large ribosomal subunit	protein binding|structural constituent of ribosome			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(1)|ovary(1)	6	Lung NSC(37;1.69e-07)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			AAATTCTTAAGAATATCTTCT	0.294000													4	15					0	0	1	0	0
SMC6	79677	broad.mit.edu	37	2	17877556	17877556	+	Splice_Site	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:17877556C>G	ENST00000448223.2	-	22	2801	c.2532G>C	c.(2530-2532)gaG>gaC	p.E844D	SMC6_ENST00000351948.4_Splice_Site_p.E844D|SMC6_ENST00000381272.4_Splice_Site_p.E870D|SMC6_ENST00000402989.1_Splice_Site_p.E844D	NM_001142286.1	NP_001135758.1	Q96SB8	SMC6_HUMAN	structural maintenance of chromosomes 6	844					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			NS(1)|biliary_tract(1)|breast(6)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	43	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GGTGAAAAACCTCTAGTTCTT	0.303000													9	19					0	0	1	0	0
TNRC6A	27327	broad.mit.edu	37	16	24802435	24802435	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:24802435G>C	ENST00000395799.3	+	6	2601	c.2472G>C	c.(2470-2472)gaG>gaC	p.E824D	TNRC6A_ENST00000315183.7_Missense_Mutation_p.E824D	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	824	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		ATTGCAAAGAGGAGAAGGCTG	0.507000													15	20					0	0	1	0	0
SEMA6D	80031	broad.mit.edu	37	15	48056959	48056959	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:48056959G>A	ENST00000316364.5	+	12	1661	c.1222G>A	c.(1222-1224)Gat>Aat	p.D408N	SEMA6D_ENST00000558014.1_Missense_Mutation_p.D408N|SEMA6D_ENST00000389433.2_Missense_Mutation_p.D408N|SEMA6D_ENST00000537942.1_Missense_Mutation_p.D408N|SEMA6D_ENST00000389428.3_Missense_Mutation_p.D408N|SEMA6D_ENST00000358066.4_Missense_Mutation_p.D408N|SEMA6D_ENST00000536845.2_Missense_Mutation_p.D408N|SEMA6D_ENST00000389432.2_Missense_Mutation_p.D408N|SEMA6D_ENST00000355997.3_Missense_Mutation_p.D408N|SEMA6D_ENST00000389425.3_Missense_Mutation_p.D408N|SEMA6D_ENST00000558816.1_Missense_Mutation_p.D408N|SEMA6D_ENST00000354744.4_Missense_Mutation_p.D408N	NM_153618.1	NP_705871.1	Q8NFY4	SEM6D_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	408	Sema.				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			biliary_tract(1)|breast(4)|endometrium(4)|kidney(5)|large_intestine(10)|lung(42)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	77		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		ACCCATTGCCGATGAGCCCTG	0.502000													4	52					0	0	1	0	0
OR2B6	26212	broad.mit.edu	37	6	27925844	27925844	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:27925844C>T	ENST00000244623.1	+	1	826	c.826C>T	c.(826-828)Ctc>Ttc	p.L276F		NM_012367.1	NP_036499.1	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B, member 6	276					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GATGGTTTCTCTCTTCTATGG	0.438000													14	67					0	0	1	0	0
FEM1A	55527	broad.mit.edu	37	19	4793724	4793724	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:4793724C>A	ENST00000269856.3	+	1	1997	c.1858C>A	c.(1858-1860)Ctg>Atg	p.L620M	AC005523.2_ENST00000601192.1_RNA	NM_018708.2	NP_061178.1	Q9BSK4	FEM1A_HUMAN	fem-1 homolog a (C. elegans)	620					regulation of ubiquitin-protein ligase activity	cytoplasm	binding|ubiquitin-protein ligase activity	p.L620M(1)		breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	17		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		GGCCTACGAGCTGCTGGACGA	0.607000													4	48					1	1	1	1	0
BCDIN3D	144233	broad.mit.edu	37	12	50232586	50232586	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:50232586G>A	ENST00000333924.4	-	2	488	c.447C>T	c.(445-447)ttC>ttT	p.F149F	BCDIN3D-AS1_ENST00000549124.1_RNA|BCDIN3D-AS1_ENST00000548872.1_RNA	NM_181708.2	NP_859059.1	Q7Z5W3	BN3D2_HUMAN	BCDIN3 domain containing	149	Bin3-type SAM.						methyltransferase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(1)|ovary(1)|skin(1)|stomach(1)	9						ATTGGCTTAAGAAAGAGCTCA	0.443000											OREG0021805	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	47					0	0	1	0	0
CRB3	92359	broad.mit.edu	37	19	6466563	6466563	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:6466563G>A	ENST00000598494.1	+	4	774	c.243G>A	c.(241-243)cgG>cgA	p.R81R	CRB3_ENST00000308243.7_Silent_p.R81R|CRB3_ENST00000600229.1_Silent_p.R81R|CRB3_ENST00000356762.3_Silent_p.R81R			Q9BUF7	CRUM3_HUMAN	crumbs homolog 3 (Drosophila)	81					protein localization in plasma membrane|tight junction assembly	apical plasma membrane|integral to membrane|tight junction	SH3 domain binding			endometrium(1)|large_intestine(1)|lung(1)	3						TGTTGGTGCGGAAGCTTCGGG	0.652000													83	98					0	0	1	0	0
ZNF844	284391	broad.mit.edu	37	19	12187226	12187226	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:12187226C>T	ENST00000439326.3	+	4	1466	c.1291C>T	c.(1291-1293)Ctt>Ttt	p.L431F	ZNF844_ENST00000441304.2_3'UTR	NM_001136501.1	NP_001129973.1	Q08AG5	ZN844_HUMAN	zinc finger protein 844	431					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(1)|prostate(1)	10						GCCTTCATTTCTTCCACTTCC	0.433000													3	61					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44684813	44684813	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:44684813C>G	ENST00000243964.3	+	22	2910	c.2812C>G	c.(2812-2814)Cga>Gga	p.R938G	SLC12A5_ENST00000454036.2_Missense_Mutation_p.R961G	NM_020708.4	NP_065759.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	961					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	AGATGAGTCACGAGGCTCAAT	0.562000													13	31					0	0	1	0	0
KCNH4	23415	broad.mit.edu	37	17	40317638	40317638	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:40317638G>A	ENST00000264661.3	-	11	2246	c.1914C>T	c.(1912-1914)ttC>ttT	p.F638F	KCNH4_ENST00000607371.1_Silent_p.F638F	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	638					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TCTTTAGCACGAAGTTTGGGT	0.592000													23	38					0	0	1	0	0
DLEC1	9940	broad.mit.edu	37	3	38080973	38080973	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:38080973C>T	ENST00000308059.6	+	1	278	c.257C>T	c.(256-258)tCg>tTg	p.S86L	DLEC1_ENST00000452631.2_Missense_Mutation_p.S86L|DLEC1_ENST00000346219.3_Missense_Mutation_p.S86L			Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1	86					negative regulation of cell proliferation	cytoplasm				NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(3)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	51				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		CGCCCCTCCTCGCTGCGCACC	0.652000													26	64					0	0	1	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39909624	39909624	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:39909624C>G	ENST00000425673.1	+	11	1569	c.1244C>G	c.(1243-1245)cCt>cGt	p.P415R	PLEKHG2_ENST00000409794.3_Missense_Mutation_p.P415R|PLEKHG2_ENST00000458508.2_Missense_Mutation_p.P356R|PLEKHG2_ENST00000409797.2_Missense_Mutation_p.P415R|PLEKHG2_ENST00000378550.1_Missense_Mutation_p.P415R			Q9H7P9	PKHG2_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	415					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|pancreas(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	40	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GAGAACCACCCTGCCTCCATC	0.602000													13	82					0	0	1	0	0
ASPM	259266	broad.mit.edu	37	1	197072567	197072567	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:197072567C>T	ENST00000367409.4	-	18	6070	c.5814G>A	c.(5812-5814)agG>agA	p.R1938R	ASPM_ENST00000294732.7_Intron|ASPM_ENST00000367408.1_Intron	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	1938					mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						TACATTGCTTCCTTCCTGCAG	0.423000													59	158					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52417423	52417423	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:52417423G>A	ENST00000420323.2	+	51	8224	c.7963G>A	c.(7963-7965)Gaa>Aaa	p.E2655K		NM_015512.4	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2655	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		ATCCTTCCTGGAAGATATCAA	0.522000													27	46					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103487275	103487275	+	Silent	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:103487275T>C	ENST00000358392.2	-	9	1649	c.1332A>G	c.(1330-1332)gcA>gcG	p.A444A	COL11A1_ENST00000512756.1_Silent_p.A316A|COL11A1_ENST00000353414.4_Silent_p.A393A|COL11A1_ENST00000370096.3_Silent_p.A432A	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	432	Triple-helical region (interrupted).				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GCTCAACCACTGCTGGTTCTC	0.358000													26	35					0	0	1	0	0
FOXD4	2298	broad.mit.edu	37	9	117910	117910	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:117910G>A	ENST00000382500.2	-	1	507	c.210C>T	c.(208-210)atC>atT	p.I70I		NM_207305.4	NP_997188.2	Q12950	FOXD4_HUMAN	forkhead box D4	70					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(5)|large_intestine(2)|lung(3)|prostate(1)|skin(3)	14	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		CGCCGCCCTCGATGTGCTCTC	0.716000													15	135					0	0	1	0	0
MTERFD1	51001	broad.mit.edu	37	8	97269316	97269316	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:97269316G>C	ENST00000523821.1	-	3	480	c.361C>G	c.(361-363)Cca>Gca	p.P121A	MTERFD1_ENST00000287025.3_Missense_Mutation_p.P121A|MTERFD1_ENST00000522822.1_5'UTR			Q96E29	MTER1_HUMAN	MTERF domain containing 1	121					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion	transcription regulatory region DNA binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	24	Breast(36;5.16e-05)					GGCTGCATTGGAGACAATGGA	0.418000													27	134					0	0	1	0	0
FIGNL1	63979	broad.mit.edu	37	7	50513083	50513083	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:50513083G>C	ENST00000419119.1	-	2	3456	c.1903C>G	c.(1903-1905)Caa>Gaa	p.Q635E	FIGNL1_ENST00000356889.4_Missense_Mutation_p.Q635E|FIGNL1_ENST00000395556.2_Missense_Mutation_p.Q635E|FIGNL1_ENST00000433017.1_Missense_Mutation_p.Q635E			Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	635					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	29	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				GGTCGAACTTGATCCGGTGTT	0.418000													16	39					0	0	1	0	0
USP4	7375	broad.mit.edu	37	3	49372916	49372916	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:49372916G>A	ENST00000351842.4	-	2	223	c.215C>T	c.(214-216)tCt>tTt	p.S72F	USP4_ENST00000416417.1_Missense_Mutation_p.S72F|USP4_ENST00000265560.4_Missense_Mutation_p.S72F|USP4_ENST00000415188.1_Missense_Mutation_p.S72F	NM_199443.2	NP_955475.1	Q13107	UBP4_HUMAN	ubiquitin specific peptidase 4 (proto-oncogene)	72	DUSP.				negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		AAATAGCCCAGAGTTGTCTAT	0.453000													45	59					0	0	1	0	0
TTC7A	57217	broad.mit.edu	37	2	47277133	47277133	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:47277133G>T	ENST00000319190.5	+	17	2333	c.1965G>T	c.(1963-1965)aaG>aaT	p.K655N	TTC7A_ENST00000409245.1_Missense_Mutation_p.K621N|TTC7A_ENST00000461601.1_3'UTR|TTC7A_ENST00000394850.2_Missense_Mutation_p.K679N|TTC7A_ENST00000263737.6_Missense_Mutation_p.K301N	NM_020458.2	NP_065191.2	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	655							binding			breast(4)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			TCACCATGAAGAAGCAGAGTG	0.572000													12	34					3.41278e-10	3.6358e-10	1	1	0
OR4C3	256144	broad.mit.edu	37	11	48346641	48346641	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:48346641G>C	ENST00000319856.4	+	1	170	c.149G>C	c.(148-150)aGa>aCa	p.R50T		NM_001004702.1	NP_001004702.1	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C, member 3	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	32						GAGGTACAGAGAGTTCTCTTT	0.478000													32	52					0	0	1	0	0
CNNM2	54805	broad.mit.edu	37	10	104679843	104679843	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:104679843G>C	ENST00000369878.4	+	1	1794	c.1606G>C	c.(1606-1608)Gaa>Caa	p.E536Q	CNNM2_ENST00000369875.3_Missense_Mutation_p.E536Q|CNNM2_ENST00000433628.2_Missense_Mutation_p.E536Q	NM_017649.4	NP_060119.3	Q9H8M5	CNNM2_HUMAN	cyclin M2		CBS 2.				ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|urinary_tract(1)	19		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CGCTATGCTGGAAGAATTTAA	0.463000													27	94					0	0	1	0	0
FOSL1	8061	broad.mit.edu	37	11	65664326	65664326	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:65664326C>A	ENST00000312562.2	-	2	437	c.251G>T	c.(250-252)cGg>cTg	p.R84L	FOSL1_ENST00000532401.1_Missense_Mutation_p.R84L|FOSL1_ENST00000531493.1_Missense_Mutation_p.R84L|FOSL1_ENST00000448083.2_Intron	NM_005438.3	NP_005429.1	P15407	FOSL1_HUMAN	FOS-like antigen 1	84					cellular defense response|chemotaxis|positive regulation of cell proliferation|response to virus|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	10				READ - Rectum adenocarcinoma(159;0.168)		CCCCAGGGCCCGGATGACTCC	0.647000													22	64					4.7796e-09	5.04201e-09	1	1	0
HSPA12A	259217	broad.mit.edu	37	10	118434641	118434641	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:118434641C>A	ENST00000369209.3	-	12	1783	c.1679G>T	c.(1678-1680)gGc>gTc	p.G560V		NM_025015.2	NP_079291.2	O43301	HS12A_HUMAN	heat shock 70kDa protein 12A	560							ATP binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32				all cancers(201;0.0158)		CCACCGAGTGCCATCCTTCAC	0.632000													3	34					0.115264	0.11591	1	1	0
MDM4	4194	broad.mit.edu	37	1	204501325	204501325	+	Silent	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:204501325C>G	ENST00000367182.3	+	5	456	c.294C>G	c.(292-294)ctC>ctG	p.L98L	MDM4_ENST00000507825.2_Silent_p.L98L|MDM4_ENST00000367183.3_Intron|MDM4_ENST00000463049.1_3'UTR|MDM4_ENST00000367180.1_Silent_p.L98L|MDM4_ENST00000391947.2_Silent_p.L98L|MDM4_ENST00000454264.2_Silent_p.L98L	NM_001204171.1|NM_001278516.1|NM_001278517.1|NM_001278518.1|NM_001278519.1|NM_002393.4	NP_001191100.1|NP_001265445.1|NP_001265446.1|NP_001265447.1|NP_001265448.1|NP_002384.2	O15151	MDM4_HUMAN	Mdm4 p53 binding protein homolog (mouse)	98	SWIB.				apoptosis|cell proliferation|cellular response to hypoxia|G0 to G1 transition|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of protein catabolic process|negative regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization	nucleus	enzyme binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	16	all_cancers(21;0.00146)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.112)|all_epithelial(62;0.118)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;3.15e-47)|all cancers(3;3.56e-32)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|Epithelial(59;0.143)|BRCA - Breast invasive adenocarcinoma(75;0.143)			ACAGCCCTCTCTATGATATGC	0.358000			A		"""GBM, bladder, retinoblastoma"""								16	38					0	0	1	0	0
SMARCE1	6605	broad.mit.edu	37	17	38787930	38787930	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:38787930C>G	ENST00000348513.6	-	9	1510	c.730G>C	c.(730-732)Gaa>Caa	p.E244Q	SMARCE1_ENST00000377808.4_Missense_Mutation_p.E209Q|SMARCE1_ENST00000578044.1_Missense_Mutation_p.E174Q|SMARCE1_ENST00000544009.1_Missense_Mutation_p.E174Q|SMARCE1_ENST00000400122.3_Missense_Mutation_p.E174Q|SMARCE1_ENST00000580419.1_Missense_Mutation_p.E209Q|SMARCE1_ENST00000431889.2_Missense_Mutation_p.E226Q|KRT222_ENST00000476049.1_3'UTR	NM_003079.4	NP_003070.3	Q969G3	SMCE1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	244					chromatin modification|negative regulation of transcription, DNA-dependent|nervous system development|nucleosome disassembly|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nuclear chromosome|SWI/SNF complex|transcriptional repressor complex	chromatin binding|DNA binding|N-acetyltransferase activity|protein binding|protein N-terminus binding|transcription coactivator activity			large_intestine(1)	1		Breast(137;0.000812)				TGAAGAAGTTCAGCTTCTAGT	0.353000													20	38					0	0	1	0	0
KCNH4	23415	broad.mit.edu	37	17	40317544	40317544	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:40317544G>A	ENST00000264661.3	-	11	2340	c.2008C>T	c.(2008-2010)Cct>Tct	p.P670S	KCNH4_ENST00000607371.1_Missense_Mutation_p.P670S	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	670					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CCATACTCAGGATAGAGCCTC	0.607000													11	41					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129899669	129899669	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:129899669C>T	ENST00000368654.3	-	14	9933	c.9558G>A	c.(9556-9558)caG>caA	p.Q3186Q	MKI67_ENST00000368653.3_Silent_p.Q2826Q	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	3186					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CTTTCCCTTTCTGATTCTGCA	0.507000													30	73					0	0	1	0	0
MKNK2	2872	broad.mit.edu	37	19	2042510	2042510	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:2042510C>T	ENST00000250896.3	-	10	910	c.666G>A	c.(664-666)gtG>gtA	p.V222V	MKNK2_ENST00000541165.1_Silent_p.V91V|MKNK2_ENST00000591601.1_Silent_p.V222V|MKNK2_ENST00000588014.1_5'UTR|MKNK2_ENST00000309340.7_Silent_p.V222V	NM_199054.2	NP_951009.1	Q9HBH9	MKNK2_HUMAN	MAP kinase interacting serine/threonine kinase 2	222	Protein kinase.				cell surface receptor linked signaling pathway|intracellular protein kinase cascade|regulation of translation		ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(1)|kidney(3)|large_intestine(3)|lung(3)	10		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACAGATCTTCACGGGGGAGA	0.692000													3	3					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858060	9858060	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:9858060C>G	ENST00000396573.2	-	14	3650	c.3341G>C	c.(3340-3342)aGa>aCa	p.R1114T	GRIN2A_ENST00000330684.3_Missense_Mutation_p.R1114T|GRIN2A_ENST00000535259.1_Missense_Mutation_p.R957T|GRIN2A_ENST00000396575.2_Missense_Mutation_p.R1114T|GRIN2A_ENST00000404927.2_Missense_Mutation_p.R1114T|GRIN2A_ENST00000562109.1_Missense_Mutation_p.R1114T	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1114					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GATCTTGTCTCTAGGGGAGCT	0.483000													31	158					0	0	1	0	0
PARP2	10038	broad.mit.edu	37	14	20824776	20824776	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:20824776G>A	ENST00000527915.1	+	13	1301	c.1296G>A	c.(1294-1296)atG>atA	p.M432I	PARP2_ENST00000429687.3_Missense_Mutation_p.M419I|PARP2_ENST00000250416.5_Missense_Mutation_p.M432I			Q9UGN5	PARP2_HUMAN	poly (ADP-ribose) polymerase 2	432	PARP catalytic.				protein ADP-ribosylation	nucleolus|nucleoplasm	DNA binding|NAD+ ADP-ribosyltransferase activity			central_nervous_system(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|pancreas(1)	15	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;5.34e-07)|all cancers(55;3.7e-06)	GBM - Glioblastoma multiforme(265;0.00888)|READ - Rectum adenocarcinoma(17;0.0649)		GTTCCAGGATGAGTAACTGGG	0.468000								Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA					57	185					0	0	1	0	0
ITGBL1	9358	broad.mit.edu	37	13	102359164	102359164	+	Silent	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr13:102359164C>G	ENST00000376180.3	+	9	1410	c.1191C>G	c.(1189-1191)ctC>ctG	p.L397L	ITGBL1_ENST00000376162.3_Silent_p.L304L|ITGBL1_ENST00000545560.2_Silent_p.L256L	NM_001271756.1|NM_004791.1	NP_001258685.1|NP_004782.1	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat domains)	397	Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			breast(1)|large_intestine(6)|lung(16)|ovary(1)|prostate(4)|skin(3)	31	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TTGGAAAGCTCTGCCAACATC	0.498000													7	54					0	0	1	0	0
NBEAL1	65065	broad.mit.edu	37	2	204016211	204016211	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:204016211A>T	ENST00000449802.1	+	34	5732	c.5399A>T	c.(5398-5400)aAg>aTg	p.K1800M		NM_001114132.1	NP_001107604.1	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1	1800							binding			NS(1)|breast(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						ATTCACTGGAAGCTAGCTAAT	0.313000													8	41					0	0	1	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48599420	48599420	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:48599420G>A	ENST00000323776.5	+	10	1526	c.1364G>A	c.(1363-1365)aGa>aAa	p.R455K	MYCBPAP_ENST00000436259.2_Missense_Mutation_p.R418K	NM_032133.4	NP_115509.4	Q8TBZ2	MYBPP_HUMAN	MYCBP associated protein	418					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(8)|ovary(4)|pancreas(1)|skin(2)|urinary_tract(2)	31	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			TGCTGGATCAGAGGCAGTAAT	0.562000													33	23					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10906963	10906963	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:10906963A>T	ENST00000298232.7	-	23	1911	c.1544T>A	c.(1543-1545)gTg>gAg	p.V515E	TPTE_ENST00000361285.4_Missense_Mutation_p.V533E|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Missense_Mutation_p.V495E	NM_199259.2	NP_954868	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	533	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AAGTATCTCCACGGCAAAATC	0.353000													11	85					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78515755	78515755	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:78515755C>G	ENST00000397909.2	+	16	3958	c.3785C>G	c.(3784-3786)tCt>tGt	p.S1262C	NAV3_ENST00000536525.2_Missense_Mutation_p.S1262C|NAV3_ENST00000228327.6_Missense_Mutation_p.S1262C|NAV3_ENST00000266692.7_Intron			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1262	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						AAATCTGCCTCTGCACCTAAT	0.463000										HNSCC(70;0.22)			12	35					0	0	1	0	0
ZNF689	115509	broad.mit.edu	37	16	30616102	30616102	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:30616102G>T	ENST00000287461.3	-	3	1323	c.986C>A	c.(985-987)tCc>tAc	p.S329Y	RP11-146F11.5_ENST00000563540.1_RNA|ZNF689_ENST00000566673.1_5'UTR	NM_138447.1	NP_612456.1	Q96CS4	ZN689_HUMAN	zinc finger protein 689	329					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(1)	14			Colorectal(24;0.198)			CAGGCGAGAGGAGGAGGAGAA	0.701000													6	49					1.58986e-06	1.65125e-06	1	1	0
GCKR	2646	broad.mit.edu	37	2	27726416	27726416	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:27726416G>A	ENST00000264717.2	+	9	743	c.680G>A	c.(679-681)cGa>cAa	p.R227Q	GCKR_ENST00000424318.2_Missense_Mutation_p.R37Q	NM_001486.3	NP_001477.2	Q14397	GCKR_HUMAN	glucokinase (hexokinase 4) regulator	227	SIS 1.				carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(2)	29	Acute lymphoblastic leukemia(172;0.155)					TCAACATTCCGACAAGTAGCA	0.488000													3	63					0	0	1	0	0
SEC24A	10802	broad.mit.edu	37	5	134044472	134044472	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:134044472C>G	ENST00000398844.2	+	18	2909	c.2621C>G	c.(2620-2622)tCc>tGc	p.S874C		NM_021982.2	NP_068817.1	O95486	SC24A_HUMAN	SEC24 family member A	874					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding			NS(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	36			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GTCATTGACTCCCTTTCAGCT	0.468000													33	46					0	0	1	0	0
NMD3	51068	broad.mit.edu	37	3	160968072	160968072	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:160968072G>A	ENST00000460469.1	+	14	1794	c.1339G>A	c.(1339-1341)Gaa>Aaa	p.E447K	NMD3_ENST00000472947.1_Missense_Mutation_p.E447K|NMD3_ENST00000351193.2_Missense_Mutation_p.E447K			Q96D46	NMD3_HUMAN	NMD3 ribosome export adaptor	447	Necessary for the nuclear export of the 60S ribosomal subunit.				protein transport	cytoplasm|nucleolus|nucleoplasm				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(10)|ovary(1)|skin(1)|urinary_tract(2)	25			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)			TGAAGATCTTGAAGAAGATGA	0.279000													16	30					0	0	1	0	0
FANCI	55215	broad.mit.edu	37	15	89850893	89850893	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:89850893C>G	ENST00000310775.7	+	34	3727	c.3641C>G	c.(3640-3642)tCt>tGt	p.S1214C	FANCI_ENST00000300027.8_Missense_Mutation_p.S1154C	NM_001113378.1	NP_001106849.1	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I	1214					cell cycle|DNA repair	nucleoplasm	protein binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	Lung NSC(78;0.0472)|all_lung(78;0.089)					TCTTTCATTTCTTACGTACAG	0.443000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				23	73					0	0	1	0	0
LRFN2	57497	broad.mit.edu	37	6	40400429	40400429	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:40400429C>T	ENST00000338305.6	-	2	966	c.424G>A	c.(424-426)Gag>Aag	p.E142K		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	142						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					TCAAAAGCCTCATCTGCGATG	0.597000													33	34					0	0	1	0	0
FNBP4	23360	broad.mit.edu	37	11	47754150	47754150	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:47754150C>T	ENST00000263773.5	-	11	1771	c.1759G>A	c.(1759-1761)Gaa>Aaa	p.E587K	FNBP4_ENST00000534003.1_5'UTR	NM_015308.2	NP_056123.2	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	587										NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	44						TTTAGTTGTTCTGCTGCATCC	0.443000													28	63					0	0	1	0	0
FARP1	10160	broad.mit.edu	37	13	99047670	99047670	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr13:99047670G>A	ENST00000376586.2	+	13	1690	c.1354G>A	c.(1354-1356)Gag>Aag	p.E452K	FARP1_ENST00000319562.6_Missense_Mutation_p.E452K|FARP1_ENST00000595437.1_Missense_Mutation_p.E452K			Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)	452	Poly-Glu.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(3)|endometrium(6)|kidney(6)|large_intestine(13)|lung(16)|ovary(1)|skin(3)|urinary_tract(1)	49	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			GGAGGAAGAGGAGGAGGTCGT	0.687000													15	22					0	0	1	0	0
HECTD1	25831	broad.mit.edu	37	14	31611068	31611068	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:31611068C>T	ENST00000399332.1	-	18	3357	c.2869G>A	c.(2869-2871)Gaa>Aaa	p.E957K	HECTD1_ENST00000553700.1_Missense_Mutation_p.E957K	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	957					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		TTTTACCTTTCATCATCTTCA	0.294000													6	10					0	0	1	0	0
MYH10	4628	broad.mit.edu	37	17	8422065	8422065	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:8422065C>G	ENST00000360416.3	-	21	2526	c.2388G>C	c.(2386-2388)caG>caC	p.Q796H	MYH10_ENST00000396239.1_Missense_Mutation_p.Q786H|MYH10_ENST00000269243.4_Missense_Mutation_p.Q765H|MYH10_ENST00000379980.4_Missense_Mutation_p.Q781H	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	765	IQ.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						ATATCTTGCTCTGTCCAATTC	0.358000													22	21					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117306394	117306394	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:117306394C>T	ENST00000321322.6	-	27	5023	c.5022G>A	c.(5020-5022)aaG>aaA	p.K1674K	DSCAML1_ENST00000527706.1_Silent_p.K1404K	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1614					axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CCTTCCTCTTCTTGCGTACGA	0.597000													21	54					0	0	1	0	0
VEGFB	7423	broad.mit.edu	37	11	64002948	64002948	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:64002948G>A	ENST00000309422.2	+	2	375	c.79G>A	c.(79-81)Gat>Aat	p.D27N	VEGFB_ENST00000426086.2_Missense_Mutation_p.D27N	NM_001243733.1|NM_003377.4	NP_001230662.1|NP_003368.1	P49765	VEGFB_HUMAN	vascular endothelial growth factor B	27					anti-apoptosis|induction of positive chemotaxis|negative regulation of gene expression|negative regulation of neuron apoptosis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of mast cell chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of vascular wound healing|vascular endothelial growth factor receptor signaling pathway	extracellular region|extracellular space|membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity|heparin binding|vascular endothelial growth factor receptor 1 binding			endometrium(2)|large_intestine(2)|prostate(1)|stomach(1)	6						CTCCCAGCCTGATGCCCCTGG	0.562000													23	49					0	0	1	0	0
CYP1A2	1544	broad.mit.edu	37	15	75042806	75042806	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:75042806C>G	ENST00000343932.4	+	2	790	c.727C>G	c.(727-729)Cgc>Ggc	p.R243G		NM_000761.3	NP_000752.2	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 2	243					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	CCCCATCCTTCGCTACCTGCC	0.557000													43	65					0	0	1	0	0
RPAIN	84268	broad.mit.edu	37	17	5324736	5324736	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:5324736G>A	ENST00000381209.3	+	2	772	c.202G>A	c.(202-204)Gag>Aag	p.E68K	RPAIN_ENST00000381208.5_Missense_Mutation_p.E68K|RPAIN_ENST00000574003.1_Missense_Mutation_p.E68K|RPAIN_ENST00000536255.2_Missense_Mutation_p.E68K|RPAIN_ENST00000327154.6_Missense_Mutation_p.E68K|RPAIN_ENST00000405578.4_Missense_Mutation_p.E68K	NM_001033002.3	NP_001028174.2	Q86UA6	RIP_HUMAN	RPA interacting protein	68					DNA recombination|DNA repair|DNA-dependent DNA replication|protein import into nucleus|response to UV	cytoplasm|nucleolus|PML body	metal ion binding|protein complex binding			breast(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)	6						GATGGAAGAAGAGTGGAATGC	0.532000													31	21					0	0	1	0	0
ATRX	546	broad.mit.edu	37	X	76814231	76814231	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chrX:76814231G>A	ENST00000373344.5	-	29	6627	c.6413C>T	c.(6412-6414)tCt>tTt	p.S2138F	ATRX_ENST00000395603.3_Missense_Mutation_p.S2100F|ATRX_ENST00000480283.1_5'UTR	NM_000489.3	NP_000480.3	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	2138	Helicase C-terminal.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	TGGATTCCAAGAAGCGTCGAA	0.348000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						47	22					0	0	1	0	0
SULT1C4	27233	broad.mit.edu	37	2	108994856	108994856	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:108994856C>T	ENST00000272452.2	+	1	389	c.63C>T	c.(61-63)taC>taT	p.Y21Y	SULT1C4_ENST00000409309.3_Silent_p.Y21Y	NM_006588.2	NP_006579.2	O75897	ST1C4_HUMAN	sulfotransferase family, cytosolic, 1C, member 4	21					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol	sulfotransferase activity			endometrium(1)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	12						GTGTCAACTACGTGAAGGGAA	0.438000													61	133					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152129435	152129435	+	Splice_Site	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:152129435C>T	ENST00000316073.3	-	3	204	c.140G>A	c.(139-141)aGa>aAa	p.R47K		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	47	EF-hand 1.|S-100-like (By similarity).					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						GTCATTTGGTCTCTGTTAGGA	0.433000													9	156					0	0	1	0	0
TFAP4	7023	broad.mit.edu	37	16	4310208	4310208	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:4310208C>T	ENST00000204517.6	-	6	1033	c.705G>A	c.(703-705)gtG>gtA	p.V235V		NM_003223.2	NP_003214.1	Q01664	TFAP4_HUMAN	transcription factor AP-4 (activating enhancer binding protein 4)	235	Pro-rich.				DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation by host of viral transcription|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|regulation of S phase of mitotic cell cycle	transcriptional repressor complex	E-box binding|histone deacetylase binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|endometrium(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	14						CTGGCACGATCACCGTGGGGT	0.617000													11	20					0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23544867	23544867	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:23544867T>C	ENST00000300619.7	-	4	1119	c.914A>G	c.(913-915)cAt>cGt	p.H305R	ZNF91_ENST00000397082.2_Missense_Mutation_p.H273R|ZNF91_ENST00000599743.1_Intron	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	305						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				GGTTGAAGAATGGCTAAAAGC	0.413000													9	158					0	0	1	0	0
SARDH	1757	broad.mit.edu	37	9	136555522	136555522	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:136555522G>A	ENST00000371872.4	-	16	2306	c.2049C>T	c.(2047-2049)atC>atT	p.I683I	SARDH_ENST00000371868.1_Silent_p.I111I|SARDH_ENST00000439388.1_Silent_p.I683I|SARDH_ENST00000422262.2_Silent_p.I515I	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	683					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		CCTGGATACTGATCATACCCA	0.652000													14	37					0	0	1	0	0
TRIM72	493829	broad.mit.edu	37	16	31226097	31226097	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:31226097C>G	ENST00000322122.3	+	2	322	c.38C>G	c.(37-39)tCc>tGc	p.S13C		NM_001008274.3	NP_001008275.2	Q6ZMU5	TRI72_HUMAN	tripartite motif containing 72	13					exocytosis|muscle organ development|muscle system process|plasma membrane repair|protein homooligomerization	cytoplasmic vesicle membrane|sarcolemma	phosphatidylserine binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(9)|skin(1)	15						CAGGAGCTGTCCTGCCCGCTG	0.756000													8	15					0	0	1	0	0
LRP4	4038	broad.mit.edu	37	11	46914632	46914632	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:46914632G>A	ENST00000378623.1	-	13	1831	c.1589C>T	c.(1588-1590)tCa>tTa	p.S530L		NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	530					endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		CGAGGTGCCTGAGTCGGTCCA	0.592000													8	33					0	0	1	0	0
ADGRG1	9289	broad.mit.edu	37	16	57693541	57693541	+	Silent	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:57693541C>G	ENST00000562631.1	+	11	2035	c.1503C>G	c.(1501-1503)gtC>gtG	p.V501V	GPR56_ENST00000388812.4_Silent_p.V507V|GPR56_ENST00000379694.4_Silent_p.V337V|GPR56_ENST00000388813.5_Silent_p.V501V|GPR56_ENST00000544297.1_Silent_p.V326V|GPR56_ENST00000540164.2_Silent_p.V501V|GPR56_ENST00000379696.3_Silent_p.V507V|GPR56_ENST00000568909.1_Silent_p.V507V|GPR56_ENST00000456916.1_Silent_p.V507V|GPR56_ENST00000562558.1_Silent_p.V501V|GPR56_ENST00000538815.1_Silent_p.V501V|GPR56_ENST00000567835.1_Silent_p.V507V|GPR56_ENST00000568908.1_Silent_p.V501V			Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56	507					brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity			kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)	15						TGGTGGAGGTCTTTGGCACCT	0.627000													19	87					0	0	1	0	0
FAM161A	84140	broad.mit.edu	37	2	62066591	62066591	+	Silent	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:62066591G>T	ENST00000404929.1	-	3	1559	c.1548C>A	c.(1546-1548)ccC>ccA	p.P516P	FAM161A_ENST00000405894.3_Silent_p.P516P	NM_001201543.1	NP_001188472.1	Q3B820	F161A_HUMAN	family with sequence similarity 161, member A	516					response to stimulus|visual perception	centrosome				breast(1)|endometrium(5)|large_intestine(8)|lung(4)|ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						AAGATACCGTGGGCACGGGAG	0.498000													30	82					1.57019e-19	1.70659e-19	1	1	0
HYAL1	3373	broad.mit.edu	37	3	50340340	50340340	+	Silent	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:50340340G>T	ENST00000266031.4	-	1	663	c.48C>A	c.(46-48)ctC>ctA	p.L16L	HYAL1_ENST00000395143.2_Silent_p.L16L|HYAL1_ENST00000320295.8_Silent_p.L16L|HYAL1_ENST00000395144.2_Silent_p.L16L|HYAL1_ENST00000457214.2_Intron|HYAL1_ENST00000447605.2_Intron			Q12794	HYAL1_HUMAN	hyaluronoglucosaminidase 1	16						extracellular space|lysosome	hyalurononglucosaminidase activity			cervix(1)|endometrium(2)|large_intestine(1)|lung(6)|prostate(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)	Hyaluronidase(DB00070)	GGGCCATATCGAGTAAGGTCA	0.627000													21	45					3.01185e-09	3.18345e-09	1	1	0
ZXDC	79364	broad.mit.edu	37	3	126185066	126185066	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:126185066C>G	ENST00000389709.3	-	5	1426	c.1373G>C	c.(1372-1374)tGc>tCc	p.C458S	ZXDC_ENST00000336332.5_Missense_Mutation_p.C458S	NM_025112.4	NP_079388.3	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C	458					positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|ovary(1)	17				GBM - Glioblastoma multiforme(114;0.155)		GAGTCTGTTGCAGGTAGAAAC	0.572000													20	43					0	0	1	0	0
ZKSCAN3	80317	broad.mit.edu	37	6	28333556	28333556	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:28333556G>A	ENST00000377255.3	+	7	1408	c.1111G>A	c.(1111-1113)Gag>Aag	p.E371K	ZKSCAN3_ENST00000252211.2_Missense_Mutation_p.E371K|ZKSCAN3_ENST00000341464.5_Missense_Mutation_p.E223K	NM_001242894.1	NP_001229823.1	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	371					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(4)|large_intestine(3)|lung(8)|pancreas(1)|skin(2)|stomach(2)|urinary_tract(1)	21						GAAGCCATATGAGTGTGAAGA	0.493000													5	80					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10543493	10543493	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:10543493G>T	ENST00000583535.1	-	22	2589	c.2502C>A	c.(2500-2502)ttC>ttA	p.F834L	MYH3_ENST00000226209.7_Missense_Mutation_p.F834L	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	834					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						TGATCTTGAAGAAGAGTTTCA	0.458000													29	31					2.85442e-18	3.09612e-18	1	1	0
SYPL1	6856	broad.mit.edu	37	7	105752622	105752622	+	Silent	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:105752622G>C	ENST00000455385.2	-	1	155	c.33C>G	c.(31-33)ctC>ctG	p.L11L	SYPL1_ENST00000470347.1_Silent_p.L11L|SYPL1_ENST00000011473.2_Silent_p.L29L	NM_182715.2	NP_874384.1	Q16563	SYPL1_HUMAN	synaptophysin-like 1	29					synaptic transmission	cytoplasmic vesicle membrane|integral to plasma membrane|melanosome|synaptic vesicle	transporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|prostate(1)	7						GTGGCTCCTTGAGCGGGTTGA	0.687000													14	22					0	0	1	0	0
WDR83	84292	broad.mit.edu	37	19	12786441	12786441	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:12786441G>T	ENST00000418543.3	+	11	1252	c.903G>T	c.(901-903)caG>caT	p.Q301H	WDR83_ENST00000242796.4_Missense_Mutation_p.Q301H	NM_001099737.2	NP_001093207.1	Q9BRX9	WDR83_HUMAN	WD repeat domain 83	301					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|cytoplasm				breast(2)|large_intestine(1)|lung(1)	4						GCAGCGTCCAGTGCTGGCGAG	0.647000											OREG0025272	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	14					5.4927e-09	5.78292e-09	1	1	0
ZNF251	90987	broad.mit.edu	37	8	145979132	145979132	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:145979132C>T	ENST00000292562.7	-	4	488	c.213G>A	c.(211-213)aaG>aaA	p.K71K	ZNF251_ENST00000524394.1_Intron	NM_138367.1	NP_612376.1	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	71	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|kidney(1)|large_intestine(5)|lung(9)|stomach(1)	17	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		CCCAAAGTTCCTTCCCCTGCT	0.552000													7	13					0	0	1	0	0
KRBA2	124751	broad.mit.edu	37	17	8272483	8272483	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:8272483G>C	ENST00000396267.1	-	2	2033	c.1202C>G	c.(1201-1203)tCa>tGa	p.S401*	RP11-849F2.5_ENST00000580537.1_RNA|KRBA2_ENST00000331336.2_Nonsense_Mutation_p.S483*|RP11-849F2.5_ENST00000583963.1_RNA|RP11-849F2.7_ENST00000582471.1_3'UTR			Q6ZNG9	KRBA2_HUMAN	KRAB-A domain containing 2	483	Integrase catalytic.				DNA integration|regulation of transcription, DNA-dependent	intracellular	DNA binding			endometrium(2)|kidney(2)|large_intestine(7)|lung(5)|stomach(1)|urinary_tract(1)	18						AGTCCCTTGTGAGGTGCTGGG	0.527000													17	15					0	0	1	0	0
MSH5-SAPCD1	100532732	broad.mit.edu	37	6	31721100	31721100	+	Missense_Mutation	SNP	C	C	T	rs142533600		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:31721100C>T	ENST00000493662.2	+	11	942	c.886C>T	c.(886-888)Cat>Tat	p.H296Y	MSH5_ENST00000534153.4_Missense_Mutation_p.H296Y|MSH5_ENST00000431848.2_5'UTR|MSH5_ENST00000375750.3_Missense_Mutation_p.H279Y|MSH5_ENST00000375742.3_Missense_Mutation_p.H296Y|MSH5_ENST00000375740.3_Missense_Mutation_p.H296Y|MSH5_ENST00000375755.3_Missense_Mutation_p.H279Y|MSH5_ENST00000375703.3_Missense_Mutation_p.H279Y																							ACGTCCGACTCATGACCTGGG	0.512000													104	73					0	0	1	0	0
MSANTD2	79684	broad.mit.edu	37	11	124637361	124637361	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:124637361T>C	ENST00000526629.1	-	3	2148	c.701A>G	c.(700-702)cAg>cGg	p.Q234R	MSANTD2_ENST00000374979.3_Missense_Mutation_p.Q464R|MSANTD2_ENST00000239614.4_Missense_Mutation_p.Q412R			Q6P1R3	CK061_HUMAN	Myb/SANT-like DNA-binding domain containing 2	464																	TATTTCCACCTGTAATGAGGC	0.498000													3	134					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43821274	43821274	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:43821274G>A	ENST00000382031.1	+	5	8348	c.8317G>A	c.(8317-8319)Gaa>Aaa	p.E2773K	MAP1A_ENST00000399453.1_Missense_Mutation_p.E2535K|MAP1A_ENST00000300231.5_Missense_Mutation_p.E2535K			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2535						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CGACTCAGATGAAGATGGAGA	0.587000													37	160					0	0	1	0	0
ASNSD1	54529	broad.mit.edu	37	2	190531483	190531483	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:190531483G>A	ENST00000260952.4	+	4	1038	c.625G>A	c.(625-627)Gaa>Aaa	p.E209K	ASNSD1_ENST00000607062.1_Intron	NM_019048.2	NP_061921	Q9NWL6	ASND1_HUMAN	asparagine synthetase domain containing 1	209					asparagine biosynthetic process|glutamine metabolic process		asparagine synthase (glutamine-hydrolyzing) activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(3)	25			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0449)|all cancers(119;0.118)			GAATATTATTGAAGAAAATGT	0.338000													15	52					0	0	1	0	0
SYCP2L	221711	broad.mit.edu	37	6	10891745	10891745	+	Splice_Site	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:10891745G>C	ENST00000283141.6	+	2	305		c.e2-1		SYCP2L_ENST00000543878.1_Splice_Site|RP11-637O19.3_ENST00000480294.1_Splice_Site	NM_001040274.2	NP_001035364.2	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like							nucleus				breast(3)|central_nervous_system(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	36	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			ATTCCACACAGAAAAACAAAG	0.299000													5	57					0	0	1	0	0
TADA2A	6871	broad.mit.edu	37	17	35804849	35804849	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:35804849G>A	ENST00000394395.2	+	8	756	c.583G>A	c.(583-585)Gat>Aat	p.D195N	TADA2A_ENST00000586023.1_Missense_Mutation_p.D195N|TADA2A_ENST00000591992.1_3'UTR|TADA2A_ENST00000225396.6_Missense_Mutation_p.D195N|TADA2A_ENST00000417170.1_Missense_Mutation_p.D195N	NM_001166105.1	NP_001159577.1	O75478	TAD2A_HUMAN	transcriptional adaptor 2A	195					histone H3 acetylation|transcription from RNA polymerase II promoter	chromosome|PCAF complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|zinc ion binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|lung(3)|prostate(1)|skin(1)	13						TTTTGTTGAAGATGACTCGGA	0.403000													83	170					0	0	1	0	0
LRRC37A6P	387646	broad.mit.edu	37	10	27535438	27535438	+	RNA	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:27535438C>T	ENST00000574842.1	+	0	255																											CACTCGACTTCTGCTCTTTCT	0.403000													19	40					0	0	1	0	0
OR2T6	254879	broad.mit.edu	37	1	248550938	248550938	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:248550938G>C	ENST00000355728.2	+	1	29	c.29G>C	c.(28-30)aGa>aCa	p.R10T		NM_001005471.1	NP_001005471.1	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T, member 6	10					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(5)|lung(38)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACCTTGACCAGAGGCTTTACC	0.408000													14	62					0	0	1	0	0
SYT14	255928	broad.mit.edu	37	1	210187104	210187104	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:210187104C>G	ENST00000537238.1	+	4	465	c.74C>G	c.(73-75)tCa>tGa	p.S25*	SYT14_ENST00000367019.1_Nonsense_Mutation_p.S63*|SYT14_ENST00000472886.1_Nonsense_Mutation_p.S63*|SYT14_ENST00000534859.1_Nonsense_Mutation_p.S63*|SYT14_ENST00000367015.1_Nonsense_Mutation_p.S25*|SYT14_ENST00000271745.7_3'UTR|SYT14_ENST00000399639.2_Nonsense_Mutation_p.S63*|SYT14_ENST00000422431.1_Nonsense_Mutation_p.S108*	NM_001256006.1|NM_153262.3	NP_001242935.1|NP_694994.2	Q8NB59	SYT14_HUMAN	synaptotagmin XIV	63						integral to membrane				endometrium(4)|large_intestine(11)|lung(17)|ovary(1)|prostate(1)|skin(3)	37				OV - Ovarian serous cystadenocarcinoma(81;0.085)		GATCTTGGTTCAGAATACAGT	0.328000													14	68					0	0	1	0	0
MDC1	9656	broad.mit.edu	37	6	30672288	30672288	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:30672288C>A	ENST00000376406.3	-	10	5319	c.4672G>T	c.(4672-4674)Ggc>Tgc	p.G1558C	MDC1-AS1_ENST00000442150.1_RNA|MDC1_ENST00000376405.2_Missense_Mutation_p.G1294C	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1558	Interaction with the PRKDC complex.				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						TTTGTCCTGCCCCTAGTGGCC	0.582000								Other conserved DNA damage response genes					5	201					0.000157383	0.000160061	1	1	0
ATM	472	broad.mit.edu	37	11	108236160	108236160	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:108236160G>A	ENST00000278616.4	+	63	9481	c.9096G>A	c.(9094-9096)gtG>gtA	p.V3032V	C11orf65_ENST00000526725.1_Intron|ATM_ENST00000525178.1_3'UTR|ATM_ENST00000452508.2_Silent_p.V3032V|C11orf65_ENST00000525729.1_Intron	NM_000051.3	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	3032	FATC.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GTGGACAAGTGAATTTGCTCA	0.443000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			12	41					0	0	1	0	0
SYPL1	6856	broad.mit.edu	37	7	105752610	105752610	+	Silent	SNP	G	G	C	rs147008337	byFrequency	TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:105752610G>C	ENST00000455385.2	-	1	167	c.45C>G	c.(43-45)ctC>ctG	p.L15L	SYPL1_ENST00000470347.1_Silent_p.L15L|SYPL1_ENST00000011473.2_Silent_p.L33L	NM_182715.2	NP_874384.1	Q16563	SYPL1_HUMAN	synaptophysin-like 1	33				LGQRM -> HLQGR (in Ref. 5; X61382).	synaptic transmission	cytoplasmic vesicle membrane|integral to plasma membrane|melanosome|synaptic vesicle	transporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|prostate(1)	7						TGATGAAGCCGAGTGGCTCCT	0.692000													12	21					0	0	1	0	0
C6orf10	10665	broad.mit.edu	37	6	32261066	32261066	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:32261066C>G	ENST00000375015.4	-	26	1581	c.1381G>C	c.(1381-1383)Gag>Cag	p.E461Q	C6orf10_ENST00000533191.1_Missense_Mutation_p.E460Q|C6orf10_ENST00000442822.2_Missense_Mutation_p.E453Q|C6orf10_ENST00000447241.2_Missense_Mutation_p.E462Q|C6orf10_ENST00000527965.1_Missense_Mutation_p.E446Q|C6orf10_ENST00000375007.4_Missense_Mutation_p.E460Q			Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10	462						integral to membrane				cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|skin(1)	25						ACACTCACCTCAGTGTTCTTT	0.453000													10	233					0	0	1	0	0
C7orf63	79846	broad.mit.edu	37	7	89912334	89912334	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:89912334G>C	ENST00000389297.4	+	13	1752	c.1501G>C	c.(1501-1503)Gat>Cat	p.D501H	C7orf63_ENST00000497910.1_Missense_Mutation_p.D483H|C7orf63_ENST00000316089.8_Missense_Mutation_p.D501H	NM_001039706.2|NM_001160138.1	NP_001034795.2|NP_001153610.1	A5D8W1	CG063_HUMAN	chromosome 7 open reading frame 63	501							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(14)|ovary(1)|prostate(3)	37						TGTAAACAAAGATCTTTGTGA	0.383000													17	28					0	0	1	0	0
ADC	113451	broad.mit.edu	37	1	33562402	33562402	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:33562402C>T	ENST00000294517.6	+	9	1435	c.848C>T	c.(847-849)tCg>tTg	p.S283L	ADC_ENST00000484656.1_3'UTR|ADC_ENST00000358680.3_Missense_Mutation_p.S125L|ADC_ENST00000398167.1_Missense_Mutation_p.S283L|ADC_ENST00000373440.1_Missense_Mutation_p.S125L|ADC_ENST00000373441.1_Missense_Mutation_p.S283L|ADC_ENST00000373443.3_Missense_Mutation_p.S283L	NM_052998.2	NP_443724.1	Q96A70	ADC_HUMAN	arginine decarboxylase	283					polyamine biosynthetic process|spermatogenesis	cytosol	arginine decarboxylase activity			NS(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(2)	11		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)			L-Arginine(DB00125)|Pyridoxal Phosphate(DB00114)	TACGTGACCTCGGCCTTCACT	0.587000													6	143					0	0	1	0	0
CCDC18	343099	broad.mit.edu	37	1	93692001	93692001	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:93692001G>A	ENST00000343253.7	+	17	2786	c.2284G>A	c.(2284-2286)Gaa>Aaa	p.E762K	CCDC18_ENST00000557479.1_Missense_Mutation_p.E881K|CCDC18_ENST00000401026.3_Missense_Mutation_p.E763K|CCDC18_ENST00000338949.4_Missense_Mutation_p.E518K|CCDC18_ENST00000334652.5_Missense_Mutation_p.E58K|CCDC18_ENST00000421014.2_3'UTR			Q5T9S5	CCD18_HUMAN	coiled-coil domain containing 18	762										breast(5)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	42		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		GAAGAAATCTGAAGAGGTAAA	0.249000													12	26					0	0	1	0	0
RSPH4A	345895	broad.mit.edu	37	6	116949506	116949506	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:116949506C>T	ENST00000229554.5	+	3	1773	c.1636C>T	c.(1636-1638)Cat>Tat	p.H546Y	RSPH4A_ENST00000368580.4_Intron|RSPH4A_ENST00000368581.4_Missense_Mutation_p.H546Y	NM_001010892.2	NP_001010892.1	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A (Chlamydomonas)	546	Glu-rich.				cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke				breast(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						CAATTGGGTTCATCATGTACA	0.403000									Kartagener syndrome				37	120					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577099	7577099	+	Missense_Mutation	SNP	C	C	T	rs121912660		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:7577099C>T	ENST00000420246.2	-	8	971	c.839G>A	c.(838-840)aGa>aAa	p.R280K	TP53_ENST00000359597.4_Missense_Mutation_p.R280K|TP53_ENST00000413465.2_Intron|TP53_ENST00000445888.2_Missense_Mutation_p.R280K|TP53_ENST00000455263.2_Missense_Mutation_p.R280K|TP53_ENST00000269305.4_Missense_Mutation_p.R280K	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	280	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		R -> G (in sporadic cancers; somatic mutation).|R -> I (in sporadic cancers; somatic mutation).|R -> K (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in a sporadic cancer; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R280T(65)|p.R280K(49)|p.R280I(16)|p.0?(8)|p.?(2)|p.R280_D281delRD(2)|p.A276_R283delACPGRDRR(1)|p.C275fs*20(1)|p.A276fs*64(1)|p.L265_K305del41(1)|p.G279_R280delGR(1)|p.F270_D281del12(1)|p.G279fs*59(1)|p.D281fs*24(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.V272_K292del21(1)|p.C275_R283delCACPGRDRR(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCGCCGGTCTCTCCCAGGACA	0.542000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			12	9					0	0	1	0	0
S100A9	6280	broad.mit.edu	37	1	153330787	153330787	+	Missense_Mutation	SNP	C	C	T	rs140601192	byFrequency	TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:153330787C>T	ENST00000368738.3	+	2	71	c.28C>T	c.(28-30)Cgc>Tgc	p.R10C		NM_002965.3	NP_002956.1	P06702	S10A9_HUMAN	S100 calcium binding protein A9	10					cell-cell signaling	cytoplasm|cytoskeleton|nucleus|plasma membrane	calcium ion binding|protein binding|signal transducer activity			breast(1)|endometrium(1)|large_intestine(2)	4	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCAGCTGGAACGCAACATAGA	0.478000													39	105					0	0	1	0	0
ANKS1A	23294	broad.mit.edu	37	6	34985689	34985689	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:34985689C>T	ENST00000360359.3	+	11	2001	c.1863C>T	c.(1861-1863)cgC>cgT	p.R621R	ANKS1A_ENST00000535627.1_Intron	NM_015245.2	NP_056060.2	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1A	621						cytoplasm	protein binding			cervix(2)|endometrium(3)|large_intestine(4)|lung(16)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31						AACTCAGCCGCAGCTTGTCCA	0.592000													20	183					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2978460	2978460	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:2978460C>T	ENST00000396946.4	-	7	1273	c.870G>A	c.(868-870)ggG>ggA	p.G290G		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	290					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		GGCTGCGCTTCCCGGCCTGGG	0.632000			Mis		DLBCL								15	50					0	0	1	0	0
UHRF1	29128	broad.mit.edu	37	19	4910993	4910993	+	RNA	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:4910993C>A	ENST00000592666.1	+	0	672							Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains 1						cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|upper_aerodigestive_tract(2)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		GGCGGAAGATCCAGGAGCTGT	0.622000											OREG0025176	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	55	78					3.28615e-30	3.62285e-30	1	1	0
SSPO	23145	broad.mit.edu	37	7	149489754	149489754	+	RNA	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:149489754C>G	ENST00000378016.2	+	0	5810							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TTCCGGAGCTCCAACAACCCC	0.697000													14	26					0	0	1	0	0
NIPSNAP3A	25934	broad.mit.edu	37	9	107521388	107521388	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:107521388G>C	ENST00000374767.4	+	5	708	c.603G>C	c.(601-603)gaG>gaC	p.E201D	NIPSNAP3A_ENST00000471001.1_3'UTR	NM_015469.1	NP_056284.1			nipsnap homolog 3A (C. elegans)											autonomic_ganglia(1)|endometrium(1)|large_intestine(3)|lung(1)|stomach(1)|upper_aerodigestive_tract(1)	8						GGTGGAATGAGAGTGCAGATA	0.388000													5	9					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	63920999	63920999	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:63920999T>C	ENST00000443617.2	-	70	13069	c.12982A>G	c.(12982-12984)Acc>Gcc	p.T4328A		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	4328					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						ACATGGTTGGTATGGCCTAAG	0.468000													47	99					0	0	1	0	0
OR2B6	26212	broad.mit.edu	37	6	27925119	27925119	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:27925119C>G	ENST00000244623.1	+	1	101	c.101C>G	c.(100-102)tCt>tGt	p.S34C		NM_012367.1	NP_036499.1	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B, member 6	34					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						TTCTTGATTTCTTACACTGTG	0.418000													21	65					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39228574	39228574	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:39228574C>T	ENST00000340369.3	-	2	2591	c.2363G>A	c.(2362-2364)gGa>gAa	p.G788E	XIRP1_ENST00000396251.1_Missense_Mutation_p.G788E|XIRP1_ENST00000421646.1_Intron	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	788							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GAGGATGCCTCCATGGTGCAG	0.622000													35	35					0	0	1	0	0
ROBO1	6091	broad.mit.edu	37	3	78649319	78649319	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:78649319C>G	ENST00000436010.2	-	28	5765	c.4768G>C	c.(4768-4770)Gaa>Caa	p.E1590Q	ROBO1_ENST00000495273.1_Missense_Mutation_p.E1584Q|ROBO1_ENST00000466906.1_5'UTR|ROBO1_ENST00000464233.1_Missense_Mutation_p.E1629Q|ROBO1_ENST00000467549.1_Missense_Mutation_p.E1529Q			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	1629					activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		ACCTGCATTTCTGCAATATTT	0.378000													9	28					0	0	1	0	0
SNX33	257364	broad.mit.edu	37	15	75942838	75942838	+	Silent	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:75942838C>G	ENST00000308527.5	+	1	2592	c.1395C>G	c.(1393-1395)ctC>ctG	p.L465L		NM_153271.1	NP_695003.1	Q8WV41	SNX33_HUMAN	sorting nexin 33	465	BAR.				cell communication		phosphatidylinositol binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|prostate(1)|soft_tissue(1)|urinary_tract(2)	19						AGAATGACCTCTTCCAGATGC	0.542000													71	118					0	0	1	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36128344	36128344	+	Splice_Site	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:36128344C>A	ENST00000258840.6	-	28	4400	c.4010G>T	c.(4009-4011)cGa>cTa	p.R1337L	RALGAPA1_ENST00000382366.3_Splice_Site_p.R1303L|RALGAPA1_ENST00000389698.3_Splice_Site_p.R1290L|RALGAPA1_ENST00000307138.6_Splice_Site_p.R1290L	NM_001283044.1	NP_001269973.1	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1 (catalytic)	1290	Minimal domain that binds to TCF3/E12 (By similarity).				activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(7)|large_intestine(14)|lung(21)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TCCGACCTACCGTGCAGGACC	0.368000													27	21					1.60099e-16	1.72611e-16	1	1	0
SLC18A3	6572	broad.mit.edu	37	10	50819359	50819359	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:50819359C>T	ENST00000374115.3	+	1	1013	c.573C>T	c.(571-573)ttC>ttT	p.F191F	CHAT_ENST00000339797.1_Intron	NM_003055.2	NP_003046.2	Q16572	VACHT_HUMAN	solute carrier family 18 (vesicular acetylcholine transporter), member 3	191					neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity	p.F191F(1)		endometrium(6)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	43						GCTCAGCCTTCGCCGACACGT	0.657000													6	14					0	0	1	0	0
STAC3	246329	broad.mit.edu	37	12	57637672	57637672	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:57637672C>A	ENST00000332782.2	-	12	1219	c.1018G>T	c.(1018-1020)Gaa>Taa	p.E340*	STAC3_ENST00000546246.2_Nonsense_Mutation_p.E154*|STAC3_ENST00000554578.1_Nonsense_Mutation_p.E301*	NM_145064.1	NP_659501.1	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	340	SH3 2.				intracellular signal transduction		identical protein binding|metal ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(10)|ovary(2)|skin(1)	18						CCGCCCGCTTCGTCTCCTTTC	0.562000											OREG0021942	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	16					8.12818e-05	8.32945e-05	1	1	0
METAP1D	254042	broad.mit.edu	37	2	172928567	172928567	+	Silent	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:172928567C>G	ENST00000315796.4	+	3	714	c.327C>G	c.(325-327)ctC>ctG	p.L109L	METAP1D_ENST00000488581.1_3'UTR	NM_199227.1	NP_954697.1	Q6UB28	AMP1D_HUMAN	methionyl aminopeptidase type 1D (mitochondrial)	109					N-terminal protein amino acid modification|peptidyl-methionine modification|proteolysis	mitochondrion	aminopeptidase activity|metal ion binding|metalloexopeptidase activity			NS(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)	8						ACGTCCTCCTCTTGGCTGGGA	0.488000													23	32					0	0	1	0	0
CSPP1	79848	broad.mit.edu	37	8	68044264	68044264	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:68044264G>A	ENST00000262210.5	+	14	1792	c.1761G>A	c.(1759-1761)ccG>ccA	p.P587P	CSPP1_ENST00000412460.1_Silent_p.P293P	NM_024790.6	NP_079066.5	Q1MSJ5	CSPP1_HUMAN	centrosome and spindle pole associated protein 1	622						centrosome|microtubule|spindle				NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(17)|ovary(5)|prostate(3)|skin(1)|urinary_tract(1)	49	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			AAGATAAACCGAAACCTTCCA	0.353000													28	69					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168103798	168103798	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:168103798C>T	ENST00000409195.1	+	9	5985	c.5896C>T	c.(5896-5898)Cag>Tag	p.Q1966*	XIRP2_ENST00000409273.1_Nonsense_Mutation_p.Q1744*|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000295237.9_Nonsense_Mutation_p.Q1966*|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000420519.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1791					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AGATATTCATCAGGTTGCTGT	0.448000													18	20					0	0	1	0	0
MRPL33	9553	broad.mit.edu	37	2	27997348	27997348	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:27997348G>A	ENST00000296102.3	+	3	160	c.99G>A	c.(97-99)aaG>aaA	p.K33K	MRPL33_ENST00000379666.3_Intron|MRPL33_ENST00000483992.1_Intron	NM_004891.3	NP_004882.1	O75394	RM33_HUMAN	mitochondrial ribosomal protein L33	33					translation	mitochondrion|ribosome	structural constituent of ribosome			breast(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(172;0.155)					TCAACACCAAGAGAAACCGAC	0.453000													51	88					0	0	1	0	0
ALDH3B1	221	broad.mit.edu	37	11	67789327	67789327	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:67789327G>A	ENST00000539229.1	+	9	1047	c.931G>A	c.(931-933)Gat>Aat	p.D311N	ALDH3B1_ENST00000342456.6_Missense_Mutation_p.D275N|ALDH3B1_ENST00000007633.8_Missense_Mutation_p.D311N|ALDH3B1_ENST00000434449.1_3'UTR|ALDH3B1_ENST00000316367.6_Intron	NM_001161473.1	NP_001154945.1	P43353	AL3B1_HUMAN	aldehyde dehydrogenase 3 family, member B1	313					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase									NADH(DB00157)	CGATGAGAGCGATCGCTACAT	0.657000													44	46					0	0	1	0	0
CDYL	9425	broad.mit.edu	37	6	4943831	4943831	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:4943831C>T	ENST00000328908.5	+	7	1466	c.1335C>T	c.(1333-1335)gtC>gtT	p.V445V	CDYL_ENST00000343762.5_Silent_p.V259V|CDYL_ENST00000449732.2_Silent_p.V259V|CDYL_ENST00000397588.3_Silent_p.V391V|CDYL_ENST00000472453.1_3'UTR			Q9Y232	CDYL1_HUMAN	chromodomain protein, Y-like	445					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity			breast(2)|kidney(2)|large_intestine(9)|lung(13)|skin(1)|stomach(2)|urinary_tract(1)	30	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)		TTGTAGCAGTCAATGGCCCAG	0.383000													6	83					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100681278	100681278	+	Missense_Mutation	SNP	A	A	C	rs145957833	byFrequency	TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:100681278A>C	ENST00000306151.4	+	3	6645	c.6581A>C	c.(6580-6582)aAt>aCt	p.N2194T		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2194	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CCTGTGACCAATTCTACTGAA	0.493000													6	597					0	0	1	0	0
LETM2	137994	broad.mit.edu	37	8	38250110	38250110	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:38250110G>C	ENST00000519476.2	+	3	398	c.98G>C	c.(97-99)tGt>tCt	p.C33S	LETM2_ENST00000379957.4_Missense_Mutation_p.C33S|LETM2_ENST00000523983.2_Intron|LETM2_ENST00000524874.1_Missense_Mutation_p.C33S|LETM2_ENST00000297720.5_Intron			Q2VYF4	LETM2_HUMAN	leucine zipper-EF-hand containing transmembrane protein 2	33						integral to membrane|mitochondrial inner membrane				NS(1)|large_intestine(1)|lung(3)|prostate(2)	7	all_cancers(2;6.77e-47)|all_epithelial(2;1.01e-50)|all_lung(3;1.25e-23)|Lung NSC(2;2.76e-23)|Colorectal(12;0.000442)|Esophageal squamous(3;0.00202)	all_lung(54;0.0657)|Hepatocellular(245;0.152)|Lung NSC(58;0.175)	Epithelial(3;1.17e-42)|all cancers(3;5.44e-38)|BRCA - Breast invasive adenocarcinoma(5;5.44e-27)|LUSC - Lung squamous cell carcinoma(2;7.12e-25)|Lung(2;4.49e-22)|COAD - Colon adenocarcinoma(9;0.114)			TCCCCATCATGTGCATTTCTT	0.398000													55	329					0	0	1	0	0
GLTSCR1L	23506	broad.mit.edu	37	6	42796877	42796877	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:42796877C>T	ENST00000314073.5	+	6	982	c.806C>T	c.(805-807)tCt>tTt	p.S269F	GLTSCR1L_ENST00000394168.1_Missense_Mutation_p.S269F					GLTSCR1-like																		TTTGGGAACTCTAGTTCCAGT	0.453000													14	20					0	0	1	0	0
CNOT10	25904	broad.mit.edu	37	3	32814971	32814971	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:32814971G>C	ENST00000328834.5	+	19	2419	c.2103G>C	c.(2101-2103)caG>caC	p.Q701H	CNOT10_ENST00000454516.2_Missense_Mutation_p.Q761H|CNOT10_ENST00000331889.6_Missense_Mutation_p.Q674H	NM_015442.2	NP_056257.1	Q9H9A5	CNOTA_HUMAN	CCR4-NOT transcription complex, subunit 10	701					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(3)	23						TGGCCTTACAGATCATCAAAA	0.443000													116	315					0	0	1	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69002384	69002384	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:69002384G>A	ENST00000295381.3	+	2	512	c.93G>A	c.(91-93)caG>caA	p.Q31Q	ARHGAP25_ENST00000497079.1_Silent_p.Q24Q|ARHGAP25_ENST00000409202.3_Silent_p.Q31Q|ARHGAP25_ENST00000409220.1_Silent_p.Q24Q|ARHGAP25_ENST00000409030.3_Silent_p.Q24Q|ARHGAP25_ENST00000467265.1_Silent_p.Q31Q|ARHGAP25_ENST00000544262.1_Silent_p.Q5Q|ARHGAP25_ENST00000456116.2_3'UTR	NM_001007231.2	NP_001007232.2	P42331	RHG25_HUMAN	Rho GTPase activating protein 25	31					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(20)|ovary(3)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	52						CTGGCGAGCAGATGGCTGCCT	0.597000													178	324					0	0	1	0	0
GSTT1	2952	broad.mit.edu	37	22	24376503	24376503	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr22:24376503G>A	ENST00000248935.5	-	5	695	c.643C>T	c.(643-645)Ctg>Ttg	p.L215L	GSTT1_ENST00000439996.2_Silent_p.L97L	NM_000853.2	NP_000844.2	P30711	GSTT1_HUMAN	glutathione S-transferase theta 1	215	GST C-terminal.				glutathione metabolic process	cytosol|soluble fraction	glutathione peroxidase activity|glutathione transferase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|ovary(1)|prostate(1)|skin(1)	6					Glutathione(DB00143)	TTGGCCTTCAGAATGACCTCA	0.622000									Myelodysplasia and Acute Myeloid Leukemia (AML), Familial				28	113					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	98039506	98039506	+	Silent	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:98039506T>C	ENST00000370192.3	-	11	1249	c.1149A>G	c.(1147-1149)gaA>gaG	p.E383E		NM_000110.3	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	383					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	ATTCACACTTTTCTTCCTTAG	0.368000													16	29					0	0	1	0	0
SLCO4A1	28231	broad.mit.edu	37	20	61299480	61299480	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:61299480C>A	ENST00000217159.1	+	9	1960	c.1755C>A	c.(1753-1755)ttC>ttA	p.F585L	SLCO4A1_ENST00000470412.1_3'UTR|SLCO4A1_ENST00000370507.1_Missense_Mutation_p.F585L	NM_016354.3	NP_057438.3	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family, member 4A1	585					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(1)|lung(7)|ovary(3)|prostate(2)	21	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			TTTTCATATTCGTTGTAATTT	0.488000											OREG0026115	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	56					3.6726e-16	3.94383e-16	1	1	0
SH3RF2	153769	broad.mit.edu	37	5	145317639	145317639	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:145317639C>T	ENST00000511217.1	+	1	200	c.148C>T	c.(148-150)Ccc>Tcc	p.P50S	SH3RF2_ENST00000359120.4_Missense_Mutation_p.P50S			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	50							ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCTGCGGTGCCCCGAATGCAG	0.592000													4	37					0	0	1	0	0
PLCG1	5335	broad.mit.edu	37	20	39802354	39802354	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:39802354G>A	ENST00000373272.2	+	29	3862	c.3457G>A	c.(3457-3459)Gaa>Aaa	p.E1153K	PLCG1_ENST00000244007.3_Missense_Mutation_p.E1153K|PLCG1_ENST00000373271.1_Missense_Mutation_p.E1153K|PLCG1_ENST00000608689.1_3'UTR	NM_002660.2	NP_002651.2	P19174	PLCG1_HUMAN	phospholipase C, gamma 1	1153	C2.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			breast(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(16)|skin(6)|urinary_tract(2)	46		Myeloproliferative disorder(115;0.00878)				CAGTAACCCTGAATTTGCCTT	0.507000											OREG0025953	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	46	98					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56203518	56203518	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr18:56203518C>G	ENST00000361673.3	-	5	4114	c.3901G>C	c.(3901-3903)Gag>Cag	p.E1301Q	RP11-1151B14.4_ENST00000591360.1_RNA	NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1301							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TCAGCATCCTCTGGACTGTGA	0.507000													23	50					0	0	1	0	0
TARDBP	23435	broad.mit.edu	37	1	11078800	11078800	+	Missense_Mutation	SNP	A	A	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:11078800A>C	ENST00000240185.3	+	4	527	c.413A>C	c.(412-414)gAt>gCt	p.D138A	TARDBP_ENST00000439080.2_Missense_Mutation_p.D22A|TARDBP_ENST00000315091.3_Missense_Mutation_p.D138A	NM_007375.3	NP_031401.1	Q13148	TADBP_HUMAN	TAR DNA binding protein	138	RRM 1.				3'-UTR-mediated mRNA stabilization|cell death|mRNA processing|negative regulation by host of viral transcription|RNA splicing|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)	11	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0578)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.37e-07)|COAD - Colon adenocarcinoma(227;7.38e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)		GTCAAGAAAGATCTTAAGACT	0.368000													6	137					0	0	1	0	0
CLIP4	79745	broad.mit.edu	37	2	29386751	29386751	+	Missense_Mutation	SNP	T	T	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:29386751T>G	ENST00000320081.5	+	13	1844	c.1589T>G	c.(1588-1590)gTt>gGt	p.V530G	CLIP4_ENST00000401617.2_Missense_Mutation_p.V423G|CLIP4_ENST00000404424.1_Missense_Mutation_p.V530G|CLIP4_ENST00000401605.1_Missense_Mutation_p.V530G	NM_024692.4	NP_078968.3	Q8N3C7	CLIP4_HUMAN	CAP-GLY domain containing linker protein family, member 4	530	CAP-Gly 2.									endometrium(4)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|prostate(1)|skin(1)	26	Acute lymphoblastic leukemia(172;0.155)					GATGGTTCAGTTGGAGGTGTG	0.378000													19	109					0	0	1	0	0
SNX13	23161	broad.mit.edu	37	7	17890577	17890577	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:17890577G>C	ENST00000409389.1	-	10	1020	c.848C>G	c.(847-849)tCt>tGt	p.S283C	SNX13_ENST00000428135.3_Missense_Mutation_p.S283C			Q9Y5W8	SNX13_HUMAN	sorting nexin 13	283	PXA.				cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			breast(1)|central_nervous_system(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(13)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38	Lung NSC(10;0.0261)|all_lung(11;0.0521)					GTTGCAGTTAGAATCACGGAT	0.378000													3	12					0	0	1	0	0
ZNF761	388561	broad.mit.edu	37	19	53958826	53958826	+	RNA	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:53958826G>A	ENST00000454407.1	+	0	1518							Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		AACCTTACAAGTGTAATGAGT	0.418000													8	350					0	0	1	0	0
EHHADH	1962	broad.mit.edu	37	3	184922354	184922354	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:184922354C>T	ENST00000231887.3	-	6	835	c.760G>A	c.(760-762)Gag>Aag	p.E254K	EHHADH_ENST00000456310.1_Missense_Mutation_p.E158K	NM_001166415.1|NM_001966.3	NP_001159887.1|NP_001957.2	Q08426	ECHP_HUMAN	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	254	Enoyl-CoA hydratase / isomerase.					peroxisome	3-hydroxyacyl-CoA dehydrogenase activity|coenzyme binding|dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(3)|prostate(2)|skin(3)	24	all_cancers(143;4.04e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.98e-32)|OV - Ovarian serous cystadenocarcinoma(80;5.55e-21)		NADH(DB00157)	AGAAACAGCTCCTCCTCCTTC	0.537000													44	104					0	0	1	0	0
PALMD	54873	broad.mit.edu	37	1	100154591	100154591	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:100154591G>C	ENST00000263174.4	+	7	1150	c.775G>C	c.(775-777)Gag>Cag	p.E259Q	PALMD_ENST00000605497.1_Missense_Mutation_p.E259Q	NM_017734.4	NP_060204.1	Q9NP74	PALMD_HUMAN	palmdelphin	259					regulation of cell shape	cytoplasm|membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(6)|pancreas(1)|prostate(2)	31		all_epithelial(167;0.000813)|all_lung(203;0.0214)|Lung NSC(277;0.0216)		Epithelial(280;0.067)|all cancers(265;0.117)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)		AGAGTATCATGAGCCTGTATA	0.453000													37	78					0	0	1	0	0
PSMF1	9491	broad.mit.edu	37	20	1106163	1106163	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:1106163C>T	ENST00000335877.6	+	2	328	c.152C>T	c.(151-153)tCa>tTa	p.S51L	PSMF1_ENST00000381898.4_5'UTR|PSMF1_ENST00000333082.3_Missense_Mutation_p.S51L|PSMF1_ENST00000438768.2_Missense_Mutation_p.S51L|PSMF1_ENST00000246015.4_Missense_Mutation_p.S51L	NM_006814.3	NP_006805.2	Q92530	PSMF1_HUMAN	proteasome (prosome, macropain) inhibitor subunit 1 (PI31)	51					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome core complex	endopeptidase inhibitor activity|protein binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(8)	13						GATAAGAAGTCAGAACTGCTG	0.463000													13	37					0	0	1	0	0
FKBP9L	360132	broad.mit.edu	37	7	55750447	55750447	+	RNA	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:55750447C>G	ENST00000455909.1	-	0	770					NR_027340.1|NR_027342.1				FK506 binding protein 9-like											endometrium(1)|kidney(1)|lung(3)	5						TCTTCACAATCAGCTCAGCAT	0.488000													3	29					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124401030	124401030	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:124401030C>T	ENST00000409039.3	+	62	10420	c.10395C>T	c.(10393-10395)ttC>ttT	p.F3465F		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3465	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ACCCTGACTTCCTCAAGCAGC	0.478000													53	78					0	0	1	0	0
AFF1	4299	broad.mit.edu	37	4	88036278	88036278	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:88036278C>T	ENST00000307808.6	+	11	2692	c.2272C>T	c.(2272-2274)Cca>Tca	p.P758S	AFF1_ENST00000395146.4_Missense_Mutation_p.P765S|AFF1_ENST00000544085.1_Missense_Mutation_p.P396S	NM_005935.2	NP_005926.1	P51825	AFF1_HUMAN	AF4/FMR2 family, member 1	758						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(2)	3		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		CACTCCTCCCCCACAAAGCTT	0.597000													50	90					0	0	1	0	0
TMX2	51075	broad.mit.edu	37	11	57480128	57480128	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:57480128C>T	ENST00000278422.4	+	1	50	c.38C>T	c.(37-39)tCg>tTg	p.S13L	TMX2-CTNND1_ENST00000528395.1_Missense_Mutation_p.S13L|TMX2_ENST00000378312.4_Missense_Mutation_p.S13L	NM_015959.3	NP_057043.1	Q9Y320	TMX2_HUMAN	thioredoxin-related transmembrane protein 2	13					cell redox homeostasis	integral to membrane				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|urinary_tract(2)	12						CTCGTGTATTCGGTGCCGCGA	0.622000													10	31					0	0	1	0	0
SEC14L1	6397	broad.mit.edu	37	17	75196652	75196652	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:75196652G>C	ENST00000413679.2	+	9	1209	c.906G>C	c.(904-906)ttG>ttC	p.L302F	SEC14L1_ENST00000431431.2_Missense_Mutation_p.L268F|SEC14L1_ENST00000392476.2_Missense_Mutation_p.L302F|SEC14L1_ENST00000443798.4_Missense_Mutation_p.L302F|SEC14L1_ENST00000436233.4_Missense_Mutation_p.L302F|SEC14L1_ENST00000585618.1_Missense_Mutation_p.L302F|SEC14L1_ENST00000430767.4_Missense_Mutation_p.L302F|SEC14L1_ENST00000591437.1_Missense_Mutation_p.L268F	NM_001143998.1|NM_001143999.1|NM_003003.3	NP_001137470|NP_001137471|NP_002994	Q92503	S14L1_HUMAN	SEC14-like 1 (S. cerevisiae)	302					transport	Golgi apparatus|integral to membrane	binding			NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(2)	31						GTCAGTCTTTGACGTGGAGAA	0.458000													58	37					0	0	1	0	0
PFKL	5211	broad.mit.edu	37	21	45743762	45743762	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:45743762C>T	ENST00000403390.1	+	17	1752	c.1752C>T	c.(1750-1752)ttC>ttT	p.F584F	PFKL_ENST00000349048.4_Silent_p.F537F			P17858	K6PL_HUMAN	phosphofructokinase, liver	537					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	23				Colorectal(79;0.0811)		GCACCGACTTCAGCCTGGGCT	0.652000													13	28					0	0	1	0	0
MFSD3	113655	broad.mit.edu	37	8	145736235	145736235	+	Silent	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:145736235C>G	ENST00000301327.4	+	4	1274	c.1014C>G	c.(1012-1014)gtC>gtG	p.V338V		NM_138431.1	NP_612440.1	Q96ES6	MFSD3_HUMAN	major facilitator superfamily domain containing 3	338	Leu-rich.				transmembrane transport	integral to membrane				central_nervous_system(2)|endometrium(1)|kidney(1)|lung(4)	8	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TCACCACAGTCACCTTCACTG	0.642000													14	37					0	0	1	0	0
ABCC6	368	broad.mit.edu	37	16	16297332	16297332	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:16297332G>A	ENST00000205557.7	-	8	962	c.933C>T	c.(931-933)ttC>ttT	p.F311F	ABCC6_ENST00000574094.1_5'UTR	NM_001171.5	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	311	ABC transmembrane type-1 1.				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		TCCCCAGGAGGAAGGTAGAAT	0.592000													13	49					0	0	1	0	0
COL28A1	340267	broad.mit.edu	37	7	7516808	7516808	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:7516808G>A	ENST00000399429.3	-	14	1308	c.1168C>T	c.(1168-1170)Ccc>Tcc	p.P390S		NM_001037763.2	NP_001032852.2	Q2UY09	COSA1_HUMAN	collagen, type XXVIII, alpha 1	390	Collagen-like 3.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	42		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		GGACCACGGGGACCCTGGTTa	0.478000													8	28					0	0	1	0	0
ANKRD42	338699	broad.mit.edu	37	11	82938902	82938902	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:82938902C>G	ENST00000260047.6	+	7	1693	c.898C>G	c.(898-900)Cct>Gct	p.P300A	ANKRD42_ENST00000531895.1_Missense_Mutation_p.P301A|ANKRD42_ENST00000533342.1_Missense_Mutation_p.P301A|ANKRD42_ENST00000393392.2_Missense_Mutation_p.P273A			Q8N9B4	ANR42_HUMAN	ankyrin repeat domain 42	273										central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	18						TGGATCAACTCCTATGCATAA	0.373000													35	101					0	0	1	0	0
ARHGAP20	57569	broad.mit.edu	37	11	110582892	110582892	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:110582892C>T	ENST00000260283.4	-	2	347	c.63G>A	c.(61-63)ctG>ctA	p.L21L	ARHGAP20_ENST00000528829.1_Intron|ARHGAP20_ENST00000533353.1_Intron|ARHGAP20_ENST00000527598.1_Intron	NM_020809.3	NP_065860.2	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	21					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(18)|lung(13)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	60		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		ACACTCCTGTCAGGGAAGAGG	0.672000													7	13					0	0	1	0	0
OAS3	4940	broad.mit.edu	37	12	113388756	113388756	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:113388756C>G	ENST00000228928.7	+	7	1812	c.1633C>G	c.(1633-1635)Ctg>Gtg	p.L545V	RP1-71H24.1_ENST00000552784.1_RNA	NM_006187.2	NP_006178.2	Q9Y6K5	OAS3_HUMAN	2'-5'-oligoadenylate synthetase 3, 100kDa	545	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|skin(2)	27						GGATGTTAGCCTGCTGCCTGC	0.617000													16	34					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100350361	100350361	+	RNA	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:100350361T>C	ENST00000542585.1	+	0	2781				ZAN_ENST00000421100.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000538115.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ACGGAAAAACTCACCATCCCC	0.502000													3	87					0	0	1	0	0
HEG1	57493	broad.mit.edu	37	3	124739800	124739800	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:124739800G>C	ENST00000311127.4	-	4	1155	c.1088C>G	c.(1087-1089)tCc>tGc	p.S363C		NM_020733.1	NP_065784.1	Q9ULI3	HEG1_HUMAN	heart development protein with EGF-like domains 1	363						extracellular region|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(24)|ovary(2)|urinary_tract(4)	47						GGCAATTCTGGAGTCCTTGGG	0.527000													13	32					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43819552	43819552	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:43819552G>A	ENST00000382031.1	+	5	6626	c.6595G>A	c.(6595-6597)Gat>Aat	p.D2199N	MAP1A_ENST00000399453.1_Missense_Mutation_p.D1961N|MAP1A_ENST00000300231.5_Missense_Mutation_p.D1961N			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1961						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	ACCCTATCCTGATGAGAGAAG	0.562000													23	68					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47754527	47754527	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:47754527A>G	ENST00000359568.5	+	3	591	c.484A>G	c.(484-486)Agt>Ggt	p.S162G	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	162					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					GTTCACAGTCAGTGACCACCC	0.552000													5	96					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90162579	90162579	+	RNA	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:90162579C>T	ENST00000564451.1	+	0	1932				TUBB8P7_ENST00000567960.1_RNA																							AGGAGTATGCCGAGGAGGAGG	0.512000													4	94					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37027156	37027156	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chrX:37027156C>G	ENST00000358047.3	+	1	725	c.673C>G	c.(673-675)Cag>Gag	p.Q225E		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	225										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						TCTCCGCCCACAGCCTCCCAA	0.647000													5	52					0	0	1	0	0
ADGRG1	9289	broad.mit.edu	37	16	57693571	57693571	+	Silent	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:57693571C>G	ENST00000562631.1	+	11	2065	c.1533C>G	c.(1531-1533)ctC>ctG	p.L511L	GPR56_ENST00000388812.4_Silent_p.L517L|GPR56_ENST00000379694.4_Silent_p.L347L|GPR56_ENST00000388813.5_Silent_p.L511L|GPR56_ENST00000544297.1_Silent_p.L336L|GPR56_ENST00000540164.2_Silent_p.L511L|GPR56_ENST00000379696.3_Silent_p.L517L|GPR56_ENST00000568909.1_Silent_p.L517L|GPR56_ENST00000456916.1_Silent_p.L517L|GPR56_ENST00000562558.1_Silent_p.L511L|GPR56_ENST00000538815.1_Silent_p.L511L|GPR56_ENST00000567835.1_Silent_p.L517L|GPR56_ENST00000568908.1_Silent_p.L511L			Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56	517					brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity			kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)	15						GCTACCTACTCAAGCTGAGCG	0.622000													14	83					0	0	1	0	0
DIS3L	115752	broad.mit.edu	37	15	66625127	66625127	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:66625127C>T	ENST00000319194.5	+	16	2747	c.2486C>T	c.(2485-2487)tCa>tTa	p.S829L	DIS3L_ENST00000319212.4_Missense_Mutation_p.S912L	NM_133375.3	NP_588616.1	Q8TF46	DI3L1_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)-like	912					rRNA catabolic process	cytoplasm|exosome (RNase complex)	exonuclease activity|protein binding|ribonuclease activity|RNA binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						TTAGTCATCTCATGTGGCCCA	0.363000													37	50					0	0	1	0	0
EIF4G2	1982	broad.mit.edu	37	11	10821737	10821737	+	Silent	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:10821737G>C	ENST00000526148.1	-	18	2529	c.2019C>G	c.(2017-2019)ctC>ctG	p.L673L	EIF4G2_ENST00000525681.1_Silent_p.L673L|EIF4G2_ENST00000396525.2_Silent_p.L635L|EIF4G2_ENST00000339995.5_Silent_p.L673L|RP11-685M7.5_ENST00000532365.1_RNA	NM_001172705.1	NP_001166176	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4 gamma, 2	673					cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	43				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		AAAGTAGGAAGAGAGGAAAAT	0.413000													15	13					0	0	1	0	0
IL21R	50615	broad.mit.edu	37	16	27456588	27456588	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:27456588C>T	ENST00000337929.3	+	7	1249	c.776C>T	c.(775-777)cCa>cTa	p.P259L	IL21R_ENST00000395754.4_Missense_Mutation_p.P259L|IL21R_ENST00000564089.1_Missense_Mutation_p.P259L|IL21R_ENST00000395755.1_Missense_Mutation_p.P259L|IL21R_ENST00000564583.1_3'UTR	NM_181078.2	NP_851564.1	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor	259					natural killer cell activation	integral to membrane	interleukin-21 receptor activity			breast(2)|large_intestine(3)|lung(1)|ovary(2)	8						AAGACCCATCCATTGTGGAGG	0.552000			T	BCL6	NHL								12	13					0	0	1	0	0
MIA3	375056	broad.mit.edu	37	1	222833629	222833629	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:222833629C>T	ENST00000344922.5	+	24	5111	c.5086C>T	c.(5086-5088)Cga>Tga	p.R1696*	MIA3_ENST00000344507.1_Intron|RP11-378J18.8_ENST00000608771.1_RNA|MIA3_ENST00000340535.7_Nonsense_Mutation_p.R574*|MIA3_ENST00000344441.6_Nonsense_Mutation_p.R1696*	NM_198551.2	NP_940953.2	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	1696	Pro-rich.				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(5)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(15)|lung(37)|ovary(5)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|urinary_tract(1)	80				GBM - Glioblastoma multiforme(131;0.0199)		TACTCTCAATCGAAGAGATAT	0.463000													19	54					0	0	1	0	0
MAPK3	5595	broad.mit.edu	37	16	30134479	30134479	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:30134479C>G	ENST00000403394.1	-	1	151	c.52G>C	c.(52-54)Gag>Cag	p.E18Q	MAPK3_ENST00000322266.5_Missense_Mutation_p.E18Q|MAPK3_ENST00000395202.1_Missense_Mutation_p.E18Q|MAPK3_ENST00000395199.3_Missense_Mutation_p.E18Q|MAPK3_ENST00000263025.4_Missense_Mutation_p.E18Q	NM_001040056.1	NP_001035145.1	P27361	MK03_HUMAN	mitogen-activated protein kinase 3	18					activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|cellular response to mechanical stimulus|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|interleukin-1-mediated signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription initiation from RNA polymerase I promoter	cytosol|nucleoplasm	ATP binding|MAP kinase activity|phosphatase binding									Arsenic trioxide(DB01169)|Isoproterenol(DB01064)|Simvastatin(DB00641)|Sulindac(DB00605)	CCGACCCCCTCGGTTCTACGG	0.771000													20	7					0	0	1	0	0
TGFBRAP1	9392	broad.mit.edu	37	2	105924617	105924617	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:105924617G>A	ENST00000393359.2	-	2	568	c.142C>T	c.(142-144)Cac>Tac	p.H48Y	TGFBRAP1_ENST00000258449.1_Missense_Mutation_p.H48Y			Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor associated protein 1	48	CNH.				regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	31						AACAGGAAGTGGTAGACGAAG	0.612000													4	42					0	0	1	0	0
ZFAND6	54469	broad.mit.edu	37	15	80423554	80423554	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:80423554G>A	ENST00000261749.6	+	6	819	c.397G>A	c.(397-399)Gaa>Aaa	p.E133K	ZFAND6_ENST00000558688.1_Missense_Mutation_p.E133K|ZFAND6_ENST00000559835.1_Missense_Mutation_p.E133K|ZFAND6_ENST00000559157.1_Missense_Mutation_p.E121K|ZFAND6_ENST00000558087.1_Missense_Mutation_p.E133K|ZFAND6_ENST00000558494.1_Missense_Mutation_p.E133K|ZFAND6_ENST00000561060.1_Missense_Mutation_p.E133K|ZFAND6_ENST00000559775.1_Missense_Mutation_p.E133K	NM_001242913.1|NM_001242914.1|NM_019006.3	NP_001229842.1|NP_001229843.1|NP_061879.2	Q6FIF0	ZFAN6_HUMAN	zinc finger, AN1-type domain 6	133							DNA binding|zinc ion binding	p.E133K(1)		cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)	11						GCAGCCATCTGAAGAGCAAAG	0.388000													17	93					0	0	1	0	0
ITPKB	3707	broad.mit.edu	37	1	226827299	226827299	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:226827299C>T	ENST00000429204.1	-	6	2839	c.2512G>A	c.(2512-2514)Gag>Aag	p.E838K	ITPKB_ENST00000272117.3_Missense_Mutation_p.E838K	NM_002221.3	NP_002212.3	P27987	IP3KB_HUMAN	inositol-trisphosphate 3-kinase B	838							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(4)|prostate(1)|skin(1)	30		Prostate(94;0.0773)				CTGAAGGCCTCGGTGACCTGC	0.567000													16	35					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81741427	81741427	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:81741427G>T	ENST00000550584.2	-	17	2412	c.2117C>A	c.(2116-2118)gCc>gAc	p.A706D	PPFIA2_ENST00000548586.1_Missense_Mutation_p.A706D|PPFIA2_ENST00000541570.2_Missense_Mutation_p.A273D|PPFIA2_ENST00000549325.1_Missense_Mutation_p.A688D|PPFIA2_ENST00000550359.2_Missense_Mutation_p.A553D|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000541017.1_Intron|PPFIA2_ENST00000443686.3_Missense_Mutation_p.A607D|PPFIA2_ENST00000552948.1_Missense_Mutation_p.A706D|PPFIA2_ENST00000333447.7_Missense_Mutation_p.A688D|PPFIA2_ENST00000549396.1_Missense_Mutation_p.A706D|PPFIA2_ENST00000407050.4_Missense_Mutation_p.A632D	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	632										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						TGTAACAGAGGCAGTAATGGA	0.532000													64	103					7.07328e-35	7.81402e-35	1	1	0
DRD3	1814	broad.mit.edu	37	3	113847752	113847752	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:113847752G>A	ENST00000383673.2	-	7	1444	c.1014C>T	c.(1012-1014)ttC>ttT	p.F338F	DRD3_ENST00000295881.7_Silent_p.F305F|DRD3_ENST00000467632.1_Silent_p.F338F|DRD3_ENST00000460779.1_Silent_p.F338F	NM_000796.3	NP_000787.2	P35462	DRD3_HUMAN	dopamine receptor D3	338					activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)	36					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	AGCAGACAATGAAGGCCCCTA	0.483000													32	60					0	0	1	0	0
JADE3	9767	broad.mit.edu	37	X	46913971	46913971	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chrX:46913971G>T	ENST00000218343.4	+	9	1682	c.1384G>T	c.(1384-1386)Gag>Tag	p.E462*	PHF16_ENST00000397189.1_Nonsense_Mutation_p.E462*	NM_014735.3	NP_055550.1	Q92613	JADE3_HUMAN		462					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(2)	33						GCAGCCAAAAGAGGAAAGCAT	0.443000													10	6					0.00010058	0.000102679	1	1	0
PEG3	5178	broad.mit.edu	37	19	57335838	57335838	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:57335838C>T	ENST00000326441.9	-	4	549	c.186G>A	c.(184-186)aaG>aaA	p.K62K	PEG3_ENST00000598410.1_Intron|PEG3_ENST00000593695.1_Intron|ZIM2_ENST00000599935.1_5'UTR|ZIM2_ENST00000593711.1_Intron|PEG3_ENST00000423103.2_Silent_p.K62K|ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000594706.1_Intron|ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000391708.3_5'UTR	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	62	SCAN box.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TGATCAGGGTCTTCCGAGGCC	0.512000													12	73					0	0	1	0	0
RARG	5916	broad.mit.edu	37	12	53621231	53621231	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:53621231G>A	ENST00000425354.2	-	3	586	c.99C>T	c.(97-99)ctC>ctT	p.L33L	RARG_ENST00000394426.1_Silent_p.L33L|RARG_ENST00000543762.1_Intron|RARG_ENST00000327550.3_Intron	NM_000966.5	NP_000957.1	P13631	RARG_HUMAN	retinoic acid receptor, gamma	33	Modulating.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	GAGACCCCCTGAGTGCCCCTG	0.647000													6	14					0	0	1	0	0
LY86	9450	broad.mit.edu	37	6	6589066	6589066	+	Nonsense_Mutation	SNP	T	T	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:6589066T>A	ENST00000379953.2	+	2	451	c.99T>A	c.(97-99)tgT>tgA	p.C33*	LY86_ENST00000230568.4_Nonsense_Mutation_p.C33*|LY86-AS1_ENST00000435641.1_RNA|LY86-AS1_ENST00000429345.1_RNA			O95711	LY86_HUMAN	lymphocyte antigen 86	33					apoptosis|cell proliferation|humoral immune response|inflammatory response|innate immune response	extracellular space|plasma membrane				large_intestine(2)|lung(6)	8	Ovarian(93;0.0377)					ACGTGGTCTGTAGCGACAGCG	0.572000													9	62					0	0	1	0	0
SPRR3	6707	broad.mit.edu	37	1	152975691	152975691	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:152975691C>T	ENST00000331860.3	+	3	345	c.195C>T	c.(193-195)ggC>ggT	p.G65G	SPRR3_ENST00000542696.1_Silent_p.G65G|SPRR3_ENST00000295367.4_Silent_p.G65G	NM_005416.2	NP_005407.1	Q9UBC9	SPRR3_HUMAN	small proline-rich protein 3	65	14 X 8 AA approximate tandem repeats.			Missing (in Ref. 2; no nucleotide entry, 4; CAB65098 and 9; AAH17802).	keratinization|peptide cross-linking|wound healing	cytoplasm	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	11	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CTGAGCCAGGCTGTACCAAGG	0.557000													6	97					0	0	1	0	0
GRASP	160622	broad.mit.edu	37	12	52403023	52403023	+	Splice_Site	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:52403023G>A	ENST00000293662.4	+	2	376	c.296G>A	c.(295-297)cGg>cAg	p.R99Q	GRASP_ENST00000552963.1_3'UTR	NM_181711.2	NP_859062.1	Q7Z6J2	GRASP_HUMAN	GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein	99						cell junction|perinuclear region of cytoplasm|postsynaptic membrane				central_nervous_system(1)|large_intestine(1)|lung(1)|skin(2)	5				BRCA - Breast invasive adenocarcinoma(357;0.0967)		GAACAGCAGCGGTGAGTCACC	0.597000													37	75					0	0	1	0	0
E2F8	79733	broad.mit.edu	37	11	19253898	19253898	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:19253898C>T	ENST00000527884.1	-	7	1181	c.949G>A	c.(949-951)Gat>Aat	p.D317N	RP11-428C19.4_ENST00000527978.1_RNA|E2F8_ENST00000250024.4_Missense_Mutation_p.D317N	NM_001256371.1|NM_001256372.1	NP_001243300.1|NP_001243301.1	A0AVK6	E2F8_HUMAN	E2F transcription factor 8	317					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TTAGCTATATCATACAACCTC	0.358000													30	61					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103155835	103155835	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:103155835C>T	ENST00000428762.1	-	50	8075	c.7916G>A	c.(7915-7917)cGc>cAc	p.R2639H	RELN_ENST00000343529.5_Missense_Mutation_p.R2639H|RELN_ENST00000424685.2_Missense_Mutation_p.R2639H	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	2639					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTGCCACCAGCGGAAGCGAGT	0.512000													13	42					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79590569	79590569	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:79590569G>C	ENST00000372391.2	-	10	1816	c.1811C>G	c.(1810-1812)tCc>tGc	p.S604C	DLG5_ENST00000372388.2_Missense_Mutation_p.S604C	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	604					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			CGAGTCGTGGGAGCTGTGGGC	0.567000													10	35					0	0	1	0	0
KCTD13	253980	broad.mit.edu	37	16	29918391	29918391	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:29918391C>T	ENST00000568000.1	-	6	1793	c.792G>A	c.(790-792)ctG>ctA	p.L264L		NM_178863.3	NP_849194.1	Q8WZ19	BACD1_HUMAN	potassium channel tetramerization domain containing 13	264					cell migration|DNA replication|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(2)	7						TGAGGATGTTCAGGGTCTCCT	0.672000													85	33					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32598123	32598123	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:32598123C>T	ENST00000286827.3	-	8	2199	c.1728G>A	c.(1726-1728)atG>atA	p.M576I	TIAM1_ENST00000541036.1_Missense_Mutation_p.M576I|TIAM1_ENST00000469412.1_5'UTR	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	576					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						TCTTTTCATCCATGTCAATCT	0.448000													22	45					0	0	1	0	0
IL17RE	132014	broad.mit.edu	37	3	9956431	9956431	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:9956431C>G	ENST00000454190.2	+	15	1575	c.1490C>G	c.(1489-1491)tCt>tGt	p.S497C	IL17RE_ENST00000421412.1_Missense_Mutation_p.L506V|IL17RE_ENST00000295980.3_Missense_Mutation_p.L473V|IL17RE_ENST00000383814.3_Missense_Mutation_p.L473V	NM_001193380.1	NP_001180309.1	Q8NFR9	I17RE_HUMAN	interleukin 17 receptor E	0	SEFIR.					cytoplasm|extracellular region|integral to membrane	receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(11)|skin(1)	21				OV - Ovarian serous cystadenocarcinoma(96;5.34e-64)		GGGTGTTGTTCTGGCCCTCAC	0.617000													49	63					0	0	1	0	0
PDGFD	80310	broad.mit.edu	37	11	104034599	104034599	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:104034599C>T	ENST00000302251.5	-	1	508	c.57G>A	c.(55-57)cgG>cgA	p.R19R	PDGFD_ENST00000393158.2_Silent_p.R19R	NM_025208.4|NM_033135.3	NP_079484.1|NP_149126.1	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D	19					positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)	23		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		CAGAAGTGTCCCGACAGCTGC	0.488000											OREG0021315	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	34					0	0	1	0	0
NFATC1	4772	broad.mit.edu	37	18	77246380	77246380	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr18:77246380C>G	ENST00000253506.5	+	9	2594	c.2225C>G	c.(2224-2226)tCc>tGc	p.S742C	NFATC1_ENST00000586434.1_Intron|NFATC1_ENST00000542384.1_Intron|NFATC1_ENST00000329101.4_Missense_Mutation_p.S729C|NFATC1_ENST00000397790.2_Missense_Mutation_p.S270C|NFATC1_ENST00000545796.1_Missense_Mutation_p.S270C|NFATC1_ENST00000318065.5_Missense_Mutation_p.S729C|NFATC1_ENST00000427363.2_Missense_Mutation_p.S742C	NM_006162.3	NP_006153.2	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0	Trans-activation domain B (TAD-B).				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(1)|soft_tissue(1)	40		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		GACCCCAGCTCCTGCCTCGTG	0.662000													57	129					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86284652	86284652	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:86284652G>C	ENST00000394518.2	+	35	8079	c.7984G>C	c.(7984-7986)Gag>Cag	p.E2662Q	AKAP13_ENST00000361243.2_Missense_Mutation_p.E2666Q|AKAP13_ENST00000394510.2_Missense_Mutation_p.E907Q|AKAP13_ENST00000560579.1_3'UTR	NM_001270546.1|NM_007200.4	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	2662	Interaction with ESR1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						GAAACAGCTTGAGAGGGAACA	0.627000													14	24					0	0	1	0	0
FBXW4	6468	broad.mit.edu	37	10	103371502	103371502	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:103371502C>A	ENST00000331272.7	-	8	1620	c.1002G>T	c.(1000-1002)gaG>gaT	p.E334D	FBXW4_ENST00000470093.1_5'UTR	NM_022039.3	NP_071322.1	P57775	FBXW4_HUMAN	F-box and WD repeat domain containing 4	334					ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	ubiquitin ligase complex				breast(3)|endometrium(2)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	15		Colorectal(252;0.123)		Epithelial(162;4.35e-08)|all cancers(201;1.92e-06)		TGTCGTGGGGCTCCTCCCACT	0.592000													3	43					0.014758	0.0149525	1	1	0
IGSF5	150084	broad.mit.edu	37	21	41142978	41142978	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:41142978C>G	ENST00000380588.4	+	4	657	c.554C>G	c.(553-555)tCa>tGa	p.S185*	IGSF5_ENST00000479378.1_3'UTR	NM_001080444.1	NP_001073913.1	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily, member 5	185	Ig-like V-type 2.					integral to membrane|tight junction		p.S185*(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(7)|skin(2)|stomach(1)	23		Prostate(19;5.35e-06)				GTCAGCCATTCAAGCTATTAT	0.537000													13	29					0	0	1	0	0
SLC12A1	6557	broad.mit.edu	37	15	48548007	48548007	+	Splice_Site	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:48548007G>A	ENST00000396577.3	+	16	2157		c.e16-1		SLC12A1_ENST00000380993.3_Splice_Site|SLC12A1_ENST00000558405.1_Splice_Site	NM_001184832.1	NP_001171761.1	Q13621	S12A1_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 1						potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|prostate(2)|skin(1)	59		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	TTTATCCACAGATGTGAACTG	0.423000													3	10					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128839034	128839034	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:128839034C>A	ENST00000310343.9	-	22	6031	c.6032G>T	c.(6031-6033)gGc>gTc	p.G2011V	ARHGAP32_ENST00000392657.3_Missense_Mutation_p.G1662V|ARHGAP32_ENST00000527272.1_Missense_Mutation_p.G1662V|ARHGAP32_ENST00000524655.1_3'UTR	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	2011	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						CTGGCGCTTGCCGTGTGGTTG	0.572000													19	55					6.44725e-10	6.85498e-10	1	1	0
SMIM7	79086	broad.mit.edu	37	19	16770802	16770802	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:16770802C>T	ENST00000487416.2	-	2	82	c.36G>A	c.(34-36)ctG>ctA	p.L12L	CTC-429P9.4_ENST00000600705.1_Silent_p.L12L|CTC-429P9.4_ENST00000593962.1_5'UTR|SMIM7_ENST00000358726.6_Silent_p.L12L|SMIM7_ENST00000597711.1_Silent_p.L12L	NM_024104.3	NP_077009.2			small integral membrane protein 7																		CGGCATTCATCAGCAACGTCC	0.617000													7	26					0	0	1	0	0
DUSP22	56940	broad.mit.edu	37	6	348771	348771	+	Silent	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:348771T>C	ENST00000604971.1	+	4	1242	c.129T>C	c.(127-129)taT>taC	p.Y43Y	DUSP22_ENST00000419235.2_Silent_p.Y146Y|DUSP22_ENST00000603453.1_Silent_p.Y43Y|DUSP22_ENST00000344450.5_Silent_p.Y146Y|DUSP22_ENST00000605035.1_3'UTR|DUSP22_ENST00000605315.1_Silent_p.Y43Y			Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	146					apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(2)	26	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		CTCTCCAGTATCGGCAGTGGC	0.517000													5	107					0	0	1	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102291872	102291872	+	RNA	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:102291872G>A	ENST00000561463.1	+	0	638																											AGACCGTGTGGAACCTCATGG	0.562000													25	38					0	0	1	0	0
MSH3	4437	broad.mit.edu	37	5	79965995	79965995	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:79965995C>A	ENST00000265081.6	+	4	739	c.659C>A	c.(658-660)tCa>tAa	p.S220*		NM_002439.4	NP_002430.3	P20585	MSH3_HUMAN	mutS homolog 3	220	Interaction with EXO1.				maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		GCTTCCAAATCAGCTAACAAA	0.378000								Mismatch excision repair (MMR)					13	13					0.00010058	0.000102679	1	1	0
DPYD	1806	broad.mit.edu	37	1	97981460	97981460	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:97981460A>T	ENST00000370192.3	-	13	1662	c.1562T>A	c.(1561-1563)cTa>cAa	p.L521Q		NM_000110.3	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	521					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	AAAGAGGGGTAGTTCAGGCTT	0.388000													7	51					0	0	1	0	0
OTOF	9381	broad.mit.edu	37	2	26706333	26706333	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:26706333C>T	ENST00000272371.2	-	13	1515	c.1389G>A	c.(1387-1389)caG>caA	p.Q463Q	OTOF_ENST00000403946.3_Silent_p.Q463Q	NM_194248.2	NP_919224.1	Q9HC10	OTOF_HUMAN	otoferlin	463	C2 2.				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCAGTACCTTCTGGCCAGCAA	0.567000													20	44					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48318544	48318544	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:48318544G>T	ENST00000435803.1	+	18	7777	c.7753G>T	c.(7753-7755)Gaa>Taa	p.E2585*		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	2585					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TTTCACATTTGAAAAGATAAA	0.308000													17	65					8.00594e-06	8.25133e-06	1	1	0
ZNF626	199777	broad.mit.edu	37	19	20807460	20807460	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:20807460T>C	ENST00000601440.1	-	4	1369	c.1223A>G	c.(1222-1224)tAc>tGc	p.Y408C	CTC-513N18.7_ENST00000595094.1_lincRNA	NM_001076675.2	NP_001070143.1	Q68DY1	ZN626_HUMAN	zinc finger protein 626	408					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.Y408C(1)		breast(1)|endometrium(1)|lung(3)|skin(1)	6						GTTAGAGGAGTACTTAAAAGC	0.408000													3	137					0	0	1	0	0
NID1	4811	broad.mit.edu	37	1	236205225	236205225	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:236205225C>A	ENST00000264187.6	-	4	1202	c.1120G>T	c.(1120-1122)Gag>Tag	p.E374*	NID1_ENST00000366595.3_Nonsense_Mutation_p.E374*	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	374					cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	CCTGTTTCCTCAACTTCATCC	0.512000													27	42					4.39465e-27	4.80553e-27	1	1	0
ZW10	9183	broad.mit.edu	37	11	113608339	113608339	+	Silent	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:113608339G>C	ENST00000200135.3	-	14	2115	c.1971C>G	c.(1969-1971)ctC>ctG	p.L657L		NM_004724.3	NP_004715.1	O43264	ZW10_HUMAN	zw10 kinetochore protein	657					cell division|ER to Golgi vesicle-mediated transport|establishment of mitotic spindle orientation|meiosis|mitotic cell cycle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|protein complex assembly|protein localization to kinetochore|protein transport|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|endoplasmic reticulum membrane|kinetochore microtubule|nucleus|spindle pole	centromeric DNA binding|protein binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)	18		all_cancers(61;3.84e-16)|all_epithelial(67;1e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000237)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0421)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.94e-06)|Epithelial(105;0.000103)|all cancers(92;0.000786)		TTGCTGTATTGAGTAAAGTCC	0.433000													38	92					0	0	1	0	0
SCUBE3	222663	broad.mit.edu	37	6	35211828	35211828	+	Silent	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:35211828G>C	ENST00000274938.7	+	17	2160	c.2160G>C	c.(2158-2160)cgG>cgC	p.R720R	SCUBE3_ENST00000394681.1_Silent_p.R736R	NM_152753.2	NP_689966.2	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	720					protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(12)|lung(11)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	37						AAGCAGGACGGACCCTATGCT	0.567000													10	22					0	0	1	0	0
OR10H2	26538	broad.mit.edu	37	19	15839103	15839103	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:15839103G>A	ENST00000305899.3	+	1	270	c.250G>A	c.(250-252)Gac>Aac	p.D84N		NM_013939.2	NP_039227.1	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H, member 2	84					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(1)	27	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					CATGCTGGCCGACCTGCTGTC	0.622000													3	45					0	0	1	0	0
TNFRSF8	943	broad.mit.edu	37	1	12183421	12183421	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:12183421G>C	ENST00000263932.2	+	9	1249	c.1027G>C	c.(1027-1029)Gag>Cag	p.E343Q	TNFRSF8_ENST00000417814.2_Missense_Mutation_p.E232Q	NM_001243.3|NM_001281430.1	NP_001234.2|NP_001268359.1	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily, member 8	343					cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		AGAGAATGGCGAGGCGCCTGC	0.652000													7	14					0	0	1	0	0
FAM120A	23196	broad.mit.edu	37	9	96259828	96259828	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:96259828C>T	ENST00000277165.6	+	4	1074	c.880C>T	c.(880-882)Cag>Tag	p.Q294*	FAM120A_ENST00000340893.4_Nonsense_Mutation_p.Q294*|FAM120A_ENST00000333936.5_Nonsense_Mutation_p.Q294*|FAM120A_ENST00000375389.3_Nonsense_Mutation_p.Q294*	NM_014612.3	NP_055427.2	Q9NZB2	F120A_HUMAN	family with sequence similarity 120A	294						cytoplasm|plasma membrane	RNA binding			endometrium(5)|kidney(3)|large_intestine(8)|lung(12)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						ACGCAACATTCAGGACACCTC	0.433000													29	17					0	0	1	0	0
ZMYM6	9204	broad.mit.edu	37	1	35452810	35452810	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:35452810C>G	ENST00000357182.4	-	16	4100	c.3873G>C	c.(3871-3873)ttG>ttC	p.L1291F	ZMYM6_ENST00000373340.2_Intron|ZMYM6_ENST00000493328.1_5'UTR|ZMYM6_ENST00000487874.1_Intron	NM_007167.3	NP_009098.3	O95789	ZMYM6_HUMAN	zinc finger, MYM-type 6	1291					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(10)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	44		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				TTGACTCAGTCAAAGCTGAAA	0.368000													14	32					0	0	1	0	0
LEPRE1	64175	broad.mit.edu	37	1	43212919	43212919	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:43212919C>G	ENST00000236040.4	-	14	2119	c.2079G>C	c.(2077-2079)gaG>gaC	p.E693D	LEPRE1_ENST00000296388.5_Intron|LEPRE1_ENST00000397054.3_Intron|LEPRE1_ENST00000462474.1_Intron	NM_001243246.1	NP_001230175.1	Q32P28	P3H1_HUMAN	leucine proline-enriched proteoglycan (leprecan) 1	0					negative regulation of cell proliferation	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			large_intestine(2)|lung(15)|ovary(5)|prostate(1)|urinary_tract(3)	26	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	ACCAGCTGCTCTCACCCGCTC	0.622000											OREG0013422	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	47					0	0	1	0	0
SV2A	9900	broad.mit.edu	37	1	149884828	149884828	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:149884828C>T	ENST00000369146.3	-	2	1055	c.565G>A	c.(565-567)Gtg>Atg	p.V189M	SV2A_ENST00000369145.1_Missense_Mutation_p.V189M	NM_001278719.1|NM_014849.3	NP_001265648.1|NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	189					neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	CTGGGCAGCACGAAGCCCACC	0.582000													105	87					0	0	1	0	0
TRIM69	140691	broad.mit.edu	37	15	45047506	45047506	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:45047506G>C	ENST00000559390.1	+	3	1343	c.415G>C	c.(415-417)Gat>Cat	p.D139H	TRIM69_ENST00000558173.1_5'UTR|TRIM69_ENST00000338264.4_Intron|TRIM69_ENST00000329464.4_Missense_Mutation_p.D139H|TRIM69_ENST00000558329.1_Intron|TRIM69_ENST00000560442.1_Intron|TRIM69_ENST00000561043.1_Intron			Q86WT6	TRI69_HUMAN	tripartite motif containing 69	139	Necessary for nuclear localization (By similarity).				apoptosis	nuclear speck	zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(9)|skin(1)	20		all_cancers(109;2.47e-13)|all_epithelial(112;2.84e-11)|Lung NSC(122;2.23e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;5.5e-19)|GBM - Glioblastoma multiforme(94;1.07e-06)|Colorectal(105;0.138)|COAD - Colon adenocarcinoma(120;0.141)		TCAATGCAAGGATGCTCGGTT	0.507000													30	36					0	0	1	0	0
OR10K1	391109	broad.mit.edu	37	1	158435644	158435644	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:158435644C>G	ENST00000289451.2	+	1	373	c.293C>G	c.(292-294)gCc>gGc	p.A98G		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	98					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					CTGGGCTGTGCCATCCAAATG	0.493000													4	123					0	0	1	0	0
UBBP4	23666	broad.mit.edu	37	17	21730916	21730916	+	Missense_Mutation	SNP	G	G	T	rs111245273	by1000genomes	TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:21730916G>T	ENST00000584755.1	+	2	615	c.218G>T	c.(217-219)cGg>cTg	p.R73L	UBBP4_ENST00000578713.1_Missense_Mutation_p.R73L|UBBP4_ENST00000583708.1_Intron|UBBP4_ENST00000584398.1_Intron														p.R73L(24)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCGGAGAGGTGGT	0.552000													3	52					0.115264	0.11591	1	1	0
KIAA2018	205717	broad.mit.edu	37	3	113378792	113378792	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:113378792C>G	ENST00000316407.4	-	7	2147	c.1737G>C	c.(1735-1737)caG>caC	p.Q579H	KIAA2018_ENST00000491165.1_Intron|KIAA2018_ENST00000478658.1_Missense_Mutation_p.Q579H	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	579					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						TGATTACTATCTGTTGACCTA	0.468000													8	159					0	0	1	0	0
CCBE1	147372	broad.mit.edu	37	18	57363928	57363928	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr18:57363928C>A	ENST00000439986.4	-	2	182	c.145G>T	c.(145-147)Gag>Tag	p.E49*	RP11-2N1.2_ENST00000588946.1_RNA	NM_133459.3	NP_597716.1	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	49					lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding	p.E49K(1)		NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(3)	24		Colorectal(73;0.175)				ATTTTGCTCTCTGAGCAGATT	0.587000											OREG0025022	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	54					2.32078e-09	2.46269e-09	1	1	0
BMS1P20	96610	broad.mit.edu	37	22	22663087	22663087	+	RNA	SNP	A	A	G	rs1054158		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr22:22663087A>G	ENST00000426066.1	+	0	526					NR_027293.1																						GCTGCCACATAAGTTGTCCTT	0.303000													9	46					0	0	1	0	0
SYNPR	132204	broad.mit.edu	37	3	63542282	63542282	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:63542282G>C	ENST00000478300.1	+	4	684	c.273G>C	c.(271-273)ttG>ttC	p.L91F	SYNPR_ENST00000465156.1_Missense_Mutation_p.L71F|SYNPR_ENST00000295894.5_Missense_Mutation_p.L71F|SYNPR_ENST00000478744.1_3'UTR|SYNPR_ENST00000460711.1_Missense_Mutation_p.L82F|SYNPR_ENST00000479198.1_Missense_Mutation_p.L71F	NM_001130003.1	NP_001123475.1	Q8TBG9	SYNPR_HUMAN	synaptoporin	71	MARVEL.					cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	transporter activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	8				BRCA - Breast invasive adenocarcinoma(55;0.000918)|KIRC - Kidney renal clear cell carcinoma(15;0.0658)|Kidney(15;0.0904)		AGCTGGCATTGATTGGTGACT	0.488000													12	21					0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23544783	23544783	+	Missense_Mutation	SNP	C	C	T	rs410211		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:23544783C>T	ENST00000300619.7	-	4	1203	c.998G>A	c.(997-999)cGt>cAt	p.R333H	ZNF91_ENST00000397082.2_Missense_Mutation_p.R301H|ZNF91_ENST00000599743.1_Intron	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	333				R -> H (in Ref. 1; AAA59469).		nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R333H(1)					all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				GGTTGAAGAACGGCTAAAAGC	0.393000													6	151					0	0	1	0	0
MN1	4330	broad.mit.edu	37	22	28195117	28195117	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr22:28195117G>A	ENST00000302326.4	-	1	2369	c.1415C>T	c.(1414-1416)tCg>tTg	p.S472L		NM_002430.2	NP_002421.3	Q10571	MN1_HUMAN	meningioma (disrupted in balanced translocation) 1	472							binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	45						GCCGTTCCACGAAGCGCAGCG	0.662000			T	ETV6	"""AML, meningioma"""								13	6					0	0	1	0	0
KEAP1	9817	broad.mit.edu	37	19	10602630	10602630	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:10602630C>T	ENST00000171111.5	-	3	1495	c.948G>A	c.(946-948)gtG>gtA	p.V316V	KEAP1_ENST00000588024.1_5'UTR|KEAP1_ENST00000393623.2_Silent_p.V316V	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	316					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GGCAGGGCATCACCTGCGTGG	0.637000													14	22					0	0	1	0	0
PNMA2	10687	broad.mit.edu	37	8	26365475	26365475	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:26365475G>A	ENST00000522362.2	-	3	1691	c.797C>T	c.(796-798)tCa>tTa	p.S266L		NM_007257.5	NP_009188.1	Q9UL42	PNMA2_HUMAN	paraneoplastic Ma antigen 2	266					apoptosis	nucleolus	protein binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)	11		all_cancers(63;0.109)|Ovarian(32;2.61e-05)|all_epithelial(46;0.105)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0196)|Epithelial(17;3.13e-11)|Colorectal(74;0.123)		cacataggctgagaccttctc	0.577000													13	18					0	0	1	0	0
PALM2-AKAP2	445815	broad.mit.edu	37	9	112900730	112900730	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:112900730G>A	ENST00000374530.3	+	8	3086	c.2906G>A	c.(2905-2907)aGg>aAg	p.R969K	AKAP2_ENST00000482335.1_3'UTR|AKAP2_ENST00000510514.5_Missense_Mutation_p.R969K|AKAP2_ENST00000555236.1_Missense_Mutation_p.R969K|AKAP2_ENST00000434623.2_Missense_Mutation_p.R827K|PALM2-AKAP2_ENST00000302798.7_Missense_Mutation_p.R969K|AKAP2_ENST00000374525.1_Missense_Mutation_p.R827K|AKAP2_ENST00000259318.7_Missense_Mutation_p.R738K	NM_007203.4|NM_147150.2	NP_009134.1|NP_671492.1	Q9Y2D5	AKAP2_HUMAN		738							enzyme binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	44						GAGCTGAAGAGGCAGAGACAA	0.527000													11	45					0	0	1	0	0
PRMT2	3275	broad.mit.edu	37	21	48071832	48071832	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:48071832C>T	ENST00000334494.4	+	7	936	c.769C>T	c.(769-771)Cat>Tat	p.H257Y	PRMT2_ENST00000451211.2_Intron|PRMT2_ENST00000397638.2_Intron|PRMT2_ENST00000440086.1_Intron|PRMT2_ENST00000355680.3_Intron|PRMT2_ENST00000291705.6_Intron|PRMT2_ENST00000397637.1_Intron|PRMT2_ENST00000458387.2_Intron	NM_001242865.1	NP_001229794.1	P55345	ANM2_HUMAN	protein arginine methyltransferase 2	0	Interaction with ESR1.			KDYRS -> RIIVA (in Ref. 2; AAB48437).	developmental cell growth|induction of apoptosis|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of androgen receptor signaling pathway	cytosol|nucleus	androgen receptor binding|estrogen receptor binding|histone-arginine N-methyltransferase activity|peroxisome proliferator activated receptor binding|progesterone receptor binding|protein homodimerization activity|retinoic acid receptor binding|signal transducer activity|thyroid hormone receptor binding|transcription coactivator activity			NS(1)|breast(3)|endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	16	Breast(49;0.247)	Lung NSC(3;0.245)		Epithelial(3;1.03e-07)|OV - Ovarian serous cystadenocarcinoma(3;4.68e-07)|all cancers(3;7.48e-07)|Colorectal(79;0.167)|Lung(125;0.203)|LUSC - Lung squamous cell carcinoma(216;0.23)|READ - Rectum adenocarcinoma(84;0.248)		TGTCCCTCTTCATGTCCTCCT	0.612000													22	65					0	0	1	0	0
CAND2	23066	broad.mit.edu	37	3	12859276	12859276	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:12859276G>A	ENST00000456430.2	+	10	2886	c.2845G>A	c.(2845-2847)Gag>Aag	p.E949K	CAND2_ENST00000295989.5_Missense_Mutation_p.E856K	NM_001162499.1	NP_001155971.1	O75155	CAND2_HUMAN	cullin-associated and neddylation-dissociated 2 (putative)	949					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(8)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						CGAGGGTGCTGAGGAGGGCAC	0.672000													91	57					0	0	1	0	0
SRGAP2-AS1	100873165	broad.mit.edu	37	1	121116648	121116648	+	RNA	DEL	A	A	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:121116648delA	ENST00000437515.1	-	0	329					NR_104189.1																						GCCCCCCTTTAAAAAAAAAGG	0.398													13	181	---	---	---	---					
TCHH	7062	broad.mit.edu	37	1	152083818	152083820	+	In_Frame_Del	DEL	CGG	CGG	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:152083818_152083820delCGG	ENST00000368804.1	-	2	1872_1874	c.1873_1875delCCG	c.(1873-1875)ccgdel	p.P625del		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	625	9 X 28 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTCTTCCTCCGGCTCCTCGCGC	0.680													8	184	---	---	---	---					
DAP3	7818	broad.mit.edu	37	1	155698864	155698867	+	Frame_Shift_Del	DEL	AGAG	AGAG	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:155698864_155698867delAGAG	ENST00000368336.5	+	8	759_762	c.635_638delAGAG	c.(634-639)aagagafs	p.KR212fs	DAP3_ENST00000421487.2_Frame_Shift_Del_p.KR178fs|DAP3_ENST00000343043.3_Frame_Shift_Del_p.KR212fs|MSTO1_ENST00000538143.1_Intron|DAP3_ENST00000471642.2_Frame_Shift_Del_p.KR171fs|MSTO1_ENST00000452804.2_Intron|DAP3_ENST00000535183.1_Frame_Shift_Del_p.KR171fs	NM_001199849.1|NM_004632.3	NP_001186778.1|NP_004623.1	P51398	RT29_HUMAN	death associated protein 3	212					induction of apoptosis by extracellular signals	mitochondrial ribosome|nucleolus|small ribosomal subunit	protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	24	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					GTCTGGAATAAGAGAGAAAGCACT	0.397													9	61	---	---	---	---					
IL17RC	84818	broad.mit.edu	37	3	9974358	9974360	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:9974358_9974360delTCC	ENST00000295981.3	+	17	1885_1887	c.1667_1669delTCC	c.(1666-1671)atcctc>atc	p.L559del	IL17RC_ENST00000498214.1_3'UTR|IL17RC_ENST00000413608.1_In_Frame_Del_p.L488del|IL17RC_ENST00000383812.4_In_Frame_Del_p.L473del|IL17RC_ENST00000403601.3_In_Frame_Del_p.L488del|IL17RC_ENST00000455057.1_In_Frame_Del_p.L456del|IL17RC_ENST00000416074.2_In_Frame_Del_p.L327del	NM_153461.3	NP_703191	Q8NAC3	I17RC_HUMAN	interleukin 17 receptor C	559						integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(3)|ovary(3)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						CTTTCCCTCATCCTCCTTCTCAA	0.591											OREG0015383	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	54	189	---	---	---	---					
SCGB3A1	92304	broad.mit.edu	37	5	180017251	180017251	+	Frame_Shift_Del	DEL	C	C	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:180017251delC	ENST00000292641.3	-	3	372	c.295delG	c.(295-297)gccfs	p.A99fs		NM_052863.2	NP_443095.2	Q96QR1	SG3A1_HUMAN	secretoglobin, family 3A, member 1	99					negative regulation of cell growth|regulation of cell proliferation	extracellular space	cytokine activity			large_intestine(1)|lung(2)	3	all_cancers(89;7.5e-05)|all_epithelial(37;7.38e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00658)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACTGTCAGGGCCCCCTGGAAA	0.697													2	4	---	---	---	---					
SYNCRIP	10492	broad.mit.edu	37	6	86349960	86349963	+	Frame_Shift_Del	DEL	TCCT	TCCT	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:86349960_86349963delTCCT	ENST00000355238.6	-	4	557_560	c.351_354delAGGA	c.(349-354)aaaggafs	p.KG117fs	SYNCRIP_ENST00000369622.3_Frame_Shift_Del_p.KG117fs	NM_001159673.1|NM_001159674.1|NM_001159676.1|NM_001159677.1|NM_001253771.1	NP_001153145.1|NP_001153146.1|NP_001153148.1|NP_001153149.1|NP_001240700.1	O60506	HNRPQ_HUMAN	synaptotagmin binding, cytoplasmic RNA interacting protein	117					CRD-mediated mRNA stabilization|interspecies interaction between organisms	catalytic step 2 spliceosome|CRD-mediated mRNA stability complex|endoplasmic reticulum|histone pre-mRNA 3'end processing complex|microsome|nucleoplasm	nucleotide binding|protein binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	33		all_cancers(76;0.000137)|Acute lymphoblastic leukemia(125;3.66e-08)|Prostate(29;8.2e-07)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0297)		BRCA - Breast invasive adenocarcinoma(108;0.0389)		CCTCATCTGGTCCTTTACTAGAAT	0.348													18	122	---	---	---	---					
TMEM200A	114801	broad.mit.edu	37	6	130762134	130762134	+	Frame_Shift_Del	DEL	G	G	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:130762134delG	ENST00000392429.1	+	2	2945	c.567delG	c.(565-567)atgfs	p.M189fs	TMEM200A_ENST00000296978.3_Frame_Shift_Del_p.M189fs|TMEM200A_ENST00000545622.1_Frame_Shift_Del_p.M189fs	NM_052913.2	NP_443145.1	Q86VY9	T200A_HUMAN	transmembrane protein 200A	189						integral to membrane		p.M189I(2)		NS(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(30)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		CTGGTTTGATGGGAGAAACAG	0.448													9	60	---	---	---	---					
PDE10A	10846	broad.mit.edu	37	6	165806238	165806240	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:165806238_165806240delTTC	ENST00000366882.1	-	17	1675_1677	c.1521_1523delGAA	c.(1519-1524)aagaac>aac	p.K507del	PDE10A_ENST00000539869.2_In_Frame_Del_p.K517del|PDE10A_ENST00000354448.4_In_Frame_Del_p.K507del			Q9Y233	PDE10_HUMAN	phosphodiesterase 10A	507					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			breast(4)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(39)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	71		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	CCGCCGATAGTTCTTCTTCACAG	0.409													14	96	---	---	---	---					
DLX6	1750	broad.mit.edu	37	7	96635545	96635547	+	In_Frame_Del	DEL	CAC	CAC	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:96635545_96635547delCAC	ENST00000518156.2	+	1	686_688	c.256_258delCAC	c.(256-258)cacdel	p.H91del	DLX6_ENST00000007660.5_In_Frame_Del_p.H63del|DLX6-AS1_ENST00000430404.2_RNA|DLX6-AS1_ENST00000452769.2_RNA|DLX6-AS1_ENST00000605417.1_RNA|DLX6-AS1_ENST00000437331.2_RNA|DLX6-AS1_ENST00000458352.2_RNA|DLX6-AS1_ENST00000430027.3_RNA|DLX6-AS1_ENST00000437541.1_RNA			P56179	DLX6_HUMAN	distal-less homeobox 6	0					nervous system development|skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(1)|liver(2)|lung(4)|ovary(2)|urinary_tract(1)	12	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					GGCCGGCTCGcaccaccaccacc	0.729													3	6	---	---	---	---					
SSPO	23145	broad.mit.edu	37	7	149515189	149515189	+	RNA	DEL	A	A	-	rs112122477		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:149515189delA	ENST00000378016.2	+	0	11577							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GACCTCGAGTAACTGCCCCAG	0.667													4	7	---	---	---	---					
KANK1	23189	broad.mit.edu	37	9	713382	713383	+	Frame_Shift_Del	DEL	TA	TA	-	rs144413163		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:713382_713383delTA	ENST00000382303.1	+	7	3268_3269	c.2616_2617delTA	c.(2614-2619)tctatcfs	p.I873fs	KANK1_ENST00000489369.1_3'UTR|KANK1_ENST00000382297.2_Frame_Shift_Del_p.I873fs|KANK1_ENST00000382293.3_Frame_Shift_Del_p.I715fs	NM_001256876.1	NP_001243805.1	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1	873					negative regulation of actin filament polymerization	cytoplasm				autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|stomach(4)|upper_aerodigestive_tract(1)	43		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		CCCTGTCGTCTATCAACTCTGT	0.515													29	58	---	---	---	---					
DDX58	23586	broad.mit.edu	37	9	32487490	32487493	+	Frame_Shift_Del	DEL	CTTG	CTTG	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:32487490_32487493delCTTG	ENST00000379882.1	-	8	1373_1376	c.1216_1219delCAAG	c.(1216-1221)caagttfs	p.QV406fs	DDX58_ENST00000379883.2_Frame_Shift_Del_p.QV451fs|DDX58_ENST00000545044.1_Frame_Shift_Del_p.QV248fs|DDX58_ENST00000542096.1_Frame_Shift_Del_p.QV380fs|DDX58_ENST00000379868.1_Frame_Shift_Del_p.QV248fs			O95786	DDX58_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	451	Helicase ATP-binding.				detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		TTATAAACAACTTGCTCCAGTTCC	0.422													8	91	---	---	---	---					
PRB2	653247	broad.mit.edu	37	12	11546732	11546733	+	In_Frame_Ins	INS	-	-	AGA			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:11546732_11546733insAGA	ENST00000389362.4	-	3	314_315	c.279_280insTCT	c.(277-282)ccacct>ccaTCTcct	p.93_94PP>PSP	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2											NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			TTTCCTGGAGGTGGGGGACCTT	0.614													12	683	---	---	---	---					
LTB4R2	56413	broad.mit.edu	37	14	24780721	24780722	+	Frame_Shift_Ins	INS	-	-	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:24780721_24780722insC	ENST00000528054.1	+	1	2561_2562	c.944_945insC	c.(943-948)aacccgfs	p.NP315fs	LTB4R_ENST00000345363.3_5'UTR|LTB4R2_ENST00000533293.1_Frame_Shift_Ins_p.NP284fs|LTB4R2_ENST00000543919.1_Frame_Shift_Ins_p.NP284fs			Q9NPC1	LT4R2_HUMAN	leukotriene B4 receptor 2	315					chemotaxis|negative regulation of adenylate cyclase activity	integral to plasma membrane				endometrium(1)|lung(1)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.018)		TCTAGCGTCAACCCGGTGCTCT	0.698													21	54	---	---	---	---					
NPTN	27020	broad.mit.edu	37	15	73866075	73866080	+	In_Frame_Del	DEL	AGTGGC	AGTGGC	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:73866075_73866080delAGTGGC	ENST00000351217.6	-	4	1333_1338	c.415_420delGCCACT	c.(415-420)gccactdel	p.AT139del	NPTN_ENST00000562924.1_In_Frame_Del_p.AT139del|NPTN_ENST00000345330.4_In_Frame_Del_p.AT255del|NPTN_ENST00000564551.1_5'UTR|NPTN_ENST00000563691.1_In_Frame_Del_p.AT255del|NPTN_ENST00000545878.1_In_Frame_Del_p.AT255del|NPTN_ENST00000287226.8_In_Frame_Del_p.AT255del|NPTN_ENST00000542234.1_In_Frame_Del_p.AT50del	NM_001161364.1|NM_017455.3	NP_001154836.1|NP_059429.1	Q9Y639	NPTN_HUMAN	neuroplastin	255					elevation of cytosolic calcium ion concentration|homophilic cell adhesion|long-term synaptic potentiation|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of long-term neuronal synaptic plasticity|positive regulation of neuron projection development|positive regulation of protein phosphorylation	integral to membrane|plasma membrane|presynaptic membrane	cell adhesion molecule binding|type 1 fibroblast growth factor receptor binding			breast(2)|cervix(1)|endometrium(2)|large_intestine(2)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	13						TGCAATACATAGTGGCATCCTGCCCT	0.549													26	96	---	---	---	---					
ITGAL	3683	broad.mit.edu	37	16	30531249	30531251	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:30531249_30531251delGCT	ENST00000356798.6	+	30	3480_3482	c.3300_3302delGCT	c.(3298-3303)gggctg>ggg	p.L1106del	ITGAL_ENST00000433423.2_In_Frame_Del_p.L340del|ITGAL_ENST00000358164.5_In_Frame_Del_p.L1022del	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	1106					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	GCATCGGGGGGCTGCTGCTGCTG	0.601													12	719	---	---	---	---					
SRCAP	10847	broad.mit.edu	37	16	30736314	30736314	+	Frame_Shift_Del	DEL	C	C	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:30736314delC	ENST00000262518.4	+	25	5954	c.5569delC	c.(5569-5571)cccfs	p.P1858fs	SRCAP_ENST00000344771.4_Frame_Shift_Del_p.P1700fs|SRCAP_ENST00000395059.2_Frame_Shift_Del_p.P1796fs	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	1858	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			GCGCTCTGGTCCCCCCAGCCC	0.612													7	972	---	---	---	---					
CTC-260E6.6	0	broad.mit.edu	37	19	20243404	20243405	+	RNA	DEL	AC	AC	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:20243404_20243405delAC	ENST00000590606.1	-	0	188				CTC-260E6.6_ENST00000586657.1_RNA|CTC-260E6.6_ENST00000593655.1_RNA																							TCCCTGGAAAACACACACACAC	0.411													7	147	---	---	---	---					
A1BG	1	broad.mit.edu	37	19	58864380	58864381	+	Frame_Shift_Del	DEL	CC	CC	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:58864380_58864381delCC	ENST00000263100.3	-	3	314_315	c.253_254delGG	c.(253-255)ggtfs	p.G85fs	A1BG-AS1_ENST00000593960.1_RNA|A1BG-AS1_ENST00000594950.1_RNA|A1BG-AS1_ENST00000600379.1_RNA|CTD-2619J13.8_ENST00000599109.1_RNA|A1BG-AS1_ENST00000595302.1_RNA|A1BG-AS1_ENST00000599728.1_RNA|A1BG-AS1_ENST00000593374.1_RNA|A1BG-AS1_ENST00000600686.1_RNA	NM_130786.3	NP_570602.2	P04217	A1BG_HUMAN	alpha-1-B glycoprotein	85	Ig-like V-type 1.					extracellular region				NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|prostate(2)	15		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)		CTGGGTGTCACCCGTCAGCAGG	0.634													16	67	---	---	---	---					
MAGEC1	9947	broad.mit.edu	37	X	140994844	140994846	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chrX:140994844_140994846delCCT	ENST00000285879.4	+	4	1940_1942	c.1654_1656delCCT	c.(1654-1656)cctdel	p.P553del	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	553							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCAGAGCCCTCCTCAGGGGG	0.567										HNSCC(15;0.026)			7	344	---	---	---	---					
