Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF680	340252	broad.mit.edu	37	7	63981603	63981603	+	Missense_Mutation	SNP	T	T	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr7:63981603T>G	ENST00000309683.6	-	4	1680	c.1529A>C	c.(1528-1530)aAa>aCa	p.K510T		NM_178558.4	NP_848653.2	Q8NEM1	ZN680_HUMAN	zinc finger protein 680	510					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)	27		Lung NSC(55;0.118)|all_lung(88;0.243)				AGTATGAATTTTCTTATGTCT	0.348000													11	48					0	0	1	0	0
SCARF2	91179	broad.mit.edu	37	22	20783846	20783846	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr22:20783846G>A	ENST00000405555.3	-	8	1471	c.1401C>T	c.(1399-1401)tgC>tgT	p.C467C	SCARF2_ENST00000266214.5_Silent_p.C467C	NM_182895.2	NP_878315.1	Q96GP6	SREC2_HUMAN	scavenger receptor class F, member 2	467					cell adhesion	integral to membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	10	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			CCTTGCCGCGGCAAGCGCAGC	0.692000													3	26					0	0	1	0	0
FAM122C	159091	broad.mit.edu	37	X	133963290	133963290	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chrX:133963290G>C	ENST00000370784.4	+	3	630	c.224G>C	c.(223-225)aGc>aCc	p.S75T	FAM122C_ENST00000445123.1_5'UTR|FAM122C_ENST00000370785.3_Missense_Mutation_p.S75T	NM_001170779.1	NP_001164250.1	Q6P4D5	F222C_HUMAN	family with sequence similarity 122C	75										endometrium(2)|kidney(1)|lung(2)	5	Acute lymphoblastic leukemia(192;0.000127)					GGTTCCATCAGCCGCCTTCAT	0.318000													26	93					0	0	1	0	0
CARD8	22900	broad.mit.edu	37	19	48714987	48714987	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:48714987G>A	ENST00000391898.3	-	11	1636	c.1594C>T	c.(1594-1596)Ctt>Ttt	p.L532F	CTC-453G23.8_ENST00000595201.1_RNA|CARD8_ENST00000520015.1_3'UTR|ZNF114_ENST00000597695.1_Intron|CARD8_ENST00000447740.2_Missense_Mutation_p.L482F|CARD8_ENST00000359009.4_Missense_Mutation_p.L426F|CARD8_ENST00000521613.1_Missense_Mutation_p.L482F|CARD8_ENST00000520753.1_3'UTR|CARD8_ENST00000519940.1_Missense_Mutation_p.L532F|CARD8_ENST00000357778.5_Intron|CARD8_ENST00000520153.1_Missense_Mutation_p.L482F	NM_001184900.1	NP_001171829.1	Q9Y2G2	CARD8_HUMAN	caspase recruitment domain family, member 8	426					negative regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion	cytoplasm|nucleus	caspase activator activity|NACHT domain binding|protein homodimerization activity			endometrium(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	15		all_lung(116;0.000112)|Lung NSC(112;0.000192)|all_epithelial(76;0.000349)|all_neural(266;0.0228)|Ovarian(192;0.113)|Prostate(7;0.184)		OV - Ovarian serous cystadenocarcinoma(262;0.000112)|all cancers(93;0.000293)|Epithelial(262;0.0129)|GBM - Glioblastoma multiforme(486;0.0336)		TGCTGTCTAAGATAGGACACG	0.453000													51	96					0	0	1	0	0
GSK3B	2932	broad.mit.edu	37	3	119595286	119595286	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:119595286G>C	ENST00000264235.8	-	8	1865	c.883C>G	c.(883-885)Caa>Gaa	p.Q295E	GSK3B_ENST00000316626.5_Missense_Mutation_p.Q295E|GSK3B_ENST00000473886.1_5'UTR	NM_001146156.1|NM_002093.3	NP_001139628.1|NP_002084.2	P49841	GSK3B_HUMAN	glycogen synthase kinase 3 beta	295	Protein kinase.				axon guidance|epithelial to mesenchymal transition|ER overload response|glycogen metabolic process|hippocampus development|negative regulation of apoptosis|negative regulation of protein binding|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|positive regulation of cell-matrix adhesion|positive regulation of protein complex assembly|positive regulation of protein export from nucleus|positive regulation of Rac GTPase activity|regulation of microtubule-based process|superior temporal gyrus development	Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|nucleus|plasma membrane	ATP binding|beta-catenin binding|NF-kappaB binding|p53 binding|protein kinase A catalytic subunit binding|protein serine/threonine kinase activity|RNA polymerase II transcription factor binding|tau-protein kinase activity|ubiquitin protein ligase binding			endometrium(1)|large_intestine(8)|lung(7)|prostate(2)	18				GBM - Glioblastoma multiforme(114;0.24)	Lithium(DB01356)	GCCTTAATTTGAGGGAATTTA	0.333000													12	55					0	0	1	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45555753	45555753	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr18:45555753C>T	ENST00000588982.1	-	4	2239	c.1738G>A	c.(1738-1740)Gag>Aag	p.E580K	ZBTB7C_ENST00000332053.2_Missense_Mutation_p.E580K|ZBTB7C_ENST00000586438.1_Missense_Mutation_p.E580K|ZBTB7C_ENST00000590800.1_Missense_Mutation_p.E580K|ZBTB7C_ENST00000535628.2_Missense_Mutation_p.E580K			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	580						intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						GCCACGTTCTCGGCCAGCGCG	0.741000													3	6					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	103984717	103984717	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:103984717G>A	ENST00000388887.2	+	2	328	c.124G>A	c.(124-126)Gag>Aag	p.E42K		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	42					angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						AATTAGGACCGAGTGCCGATC	0.433000													44	36					0	0	1	0	0
HSPA1L	3305	broad.mit.edu	37	6	31778777	31778777	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:31778777C>T	ENST00000375654.4	-	2	1162	c.973G>A	c.(973-975)Gat>Aat	p.D325N	HSPA1L_ENST00000417199.3_Missense_Mutation_p.D325N	NM_005527.3	NP_005518.3	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	325					response to unfolded protein		ATP binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|pleura(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						ATCTTGGCATCCCGAAGCGCT	0.502000													6	43					0	0	1	0	0
GPR119	139760	broad.mit.edu	37	X	129518815	129518815	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chrX:129518815C>T	ENST00000276218.2	-	1	696	c.607G>A	c.(607-609)Gaa>Aaa	p.E203K		NM_178471.2	NP_848566.1	Q8TDV5	GP119_HUMAN	G protein-coupled receptor 119	203						integral to membrane|plasma membrane	lipid binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(3)|prostate(1)	11						CCTGCATGTTCCATCTTTCGA	0.532000													24	11					0	0	1	0	0
ZNF730	100129543	broad.mit.edu	37	19	23328897	23328897	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:23328897C>T	ENST00000597761.2	+	4	1250	c.1051C>T	c.(1051-1053)Cga>Tga	p.R351*		NM_001277403.1	NP_001264332.1			zinc finger protein 730											endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|pancreas(1)|stomach(2)|urinary_tract(1)	16						AGCTTTTAACCGATCCTCAAC	0.358000													10	34					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140209543	140209543	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr5:140209543C>T	ENST00000529310.1	+	1	1981	c.1867C>T	c.(1867-1869)Cgc>Tgc	p.R623C	PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018909.2|NM_031848.2|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTCCCGTTTCGCGTGGGGCT	0.652000													25	30					0	0	1	0	0
ARFGAP1	55738	broad.mit.edu	37	20	61919072	61919072	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr20:61919072C>T	ENST00000370283.4	+	13	1208	c.1068C>T	c.(1066-1068)acC>acT	p.T356T	ARFGAP1_ENST00000519604.1_Silent_p.T311T|ARFGAP1_ENST00000370275.4_3'UTR|ARFGAP1_ENST00000519273.2_Silent_p.T243T|ARFGAP1_ENST00000518794.2_3'UTR|ARFGAP1_ENST00000547204.1_Silent_p.T290T|ARFGAP1_ENST00000353546.3_Silent_p.T364T	NM_018209.2	NP_060679.1	Q8N6T3	ARFG1_HUMAN	ADP-ribosylation factor GTPase activating protein 1	356					COPI coating of Golgi vesicle|protein transport|regulation of ARF GTPase activity|retrograde vesicle-mediated transport, Golgi to ER	cytosol|Golgi-associated vesicle membrane	ARF GTPase activator activity|zinc ion binding	p.T364T(1)		endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|pancreas(1)	13	all_cancers(38;1.59e-09)					ACACCTCCACCGAGAGGAGGA	0.657000													9	14					0	0	1	0	0
ZNF16	7564	broad.mit.edu	37	8	146157801	146157801	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr8:146157801C>T	ENST00000276816.4	-	4	558	c.372G>A	c.(370-372)agG>agA	p.R124R	ZNF16_ENST00000394909.2_Silent_p.R124R	NM_001029976.2	NP_001025147.2	P17020	ZNF16_HUMAN	zinc finger protein 16	124					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(4)|large_intestine(5)|lung(9)|ovary(5)|prostate(1)|skin(1)|urinary_tract(1)	29	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.136)	Epithelial(56;3.45e-38)|all cancers(56;3.04e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.02)|KIRC - Kidney renal clear cell carcinoma(644;0.0486)		GTGGCAGCCTCCTGCCTTCGG	0.542000													27	80					0	0	1	0	0
FDXR	2232	broad.mit.edu	37	17	72859253	72859253	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr17:72859253G>A	ENST00000442102.2	-	11	1505	c.1419C>T	c.(1417-1419)ctC>ctT	p.L473L	FDXR_ENST00000582944.1_Silent_p.L422L|FDXR_ENST00000293195.5_Silent_p.L430L|FDXR_ENST00000583917.1_Silent_p.L402L|FDXR_ENST00000420580.2_Silent_p.L390L|FDXR_ENST00000544854.1_Silent_p.L378L|FDXR_ENST00000581530.1_Silent_p.L436L|FDXR_ENST00000455107.2_3'UTR|FDXR_ENST00000413947.2_Silent_p.L461L	NM_001258012.1	NP_001244941.1	P22570	ADRO_HUMAN	ferredoxin reductase	430					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)	16	all_lung(278;0.172)|Lung NSC(278;0.207)					GGCCAGAGGGGAGCAACCCAG	0.652000													10	27					0	0	1	0	0
SEPT5	5413	broad.mit.edu	37	22	19707405	19707405	+	Silent	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr22:19707405C>G	ENST00000438754.2	+	3	535	c.255C>G	c.(253-255)ctC>ctG	p.L85L	SEPT5_ENST00000406395.1_Silent_p.L76L|SEPT5_ENST00000455784.2_Silent_p.L76L|SEPT5_ENST00000383045.3_Silent_p.L85L	NM_001009939.2	NP_001009939.1	Q99719	SEPT5_HUMAN	septin 5	76					cell cycle|cytokinesis|regulation of exocytosis|synaptic vesicle targeting	plasma membrane|septin complex|synaptic vesicle	GTP binding|GTPase activity|protein binding|structural molecule activity			lung(1)|upper_aerodigestive_tract(1)	2	Colorectal(54;0.0993)					GGAAGCTGCTCAGTGCTGAGG	0.607000													20	40					0	0	1	0	0
AGFG2	3268	broad.mit.edu	37	7	100151721	100151721	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr7:100151721C>T	ENST00000300176.4	+	5	713	c.591C>T	c.(589-591)gtC>gtT	p.V197V	AGFG2_ENST00000474713.1_3'UTR|AGFG2_ENST00000262935.4_Intron	NM_006076.4	NP_006067.3	O95081	AGFG2_HUMAN	ArfGAP with FG repeats 2	197					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CCAAGCCCGTCAGTCAGTCTC	0.597000													11	137					0	0	1	0	0
USP48	84196	broad.mit.edu	37	1	22055168	22055168	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:22055168C>A	ENST00000308271.9	-	11	1993	c.1345G>T	c.(1345-1347)Gag>Tag	p.E449*	USP48_ENST00000421625.2_Nonsense_Mutation_p.E449*|USP48_ENST00000529637.1_Nonsense_Mutation_p.E448*|USP48_ENST00000400301.1_Nonsense_Mutation_p.E449*	NM_032236.5	NP_115612.4	Q86UV5	UBP48_HUMAN	ubiquitin specific peptidase 48	449					ubiquitin-dependent protein catabolic process	mitochondrion|nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(14)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;4.66e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|OV - Ovarian serous cystadenocarcinoma(117;4.74e-26)|COAD - Colon adenocarcinoma(152;1.3e-05)|GBM - Glioblastoma multiforme(114;1.86e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000614)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00711)|Lung(427;0.0327)|READ - Rectum adenocarcinoma(331;0.0657)|LUSC - Lung squamous cell carcinoma(448;0.0753)		ATACACCACTCCTCAAATTTG	0.383000													15	45					1.3612e-06	1.42012e-06	1	1	0
FLG2	388698	broad.mit.edu	37	1	152329280	152329280	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:152329280C>G	ENST00000388718.5	-	3	1054	c.982G>C	c.(982-984)Ggc>Cgc	p.G328R	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	328	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGACACAGCCATGGCCTTGT	0.468000													43	131					0	0	1	0	0
VPS33A	65082	broad.mit.edu	37	12	122729126	122729126	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:122729126G>A	ENST00000267199.4	-	7	1071	c.959C>T	c.(958-960)gCa>gTa	p.A320V	RP11-512M8.5_ENST00000535844.1_Missense_Mutation_p.A281V	NM_022916.4	NP_075067.2	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33 homolog A (S. cerevisiae)	320					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(13)|ovary(1)|skin(2)	28	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		CTCGAATGCTGCAGAGATGAT	0.493000													5	55					0	0	1	0	0
BRPF3	27154	broad.mit.edu	37	6	36196781	36196781	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:36196781G>A	ENST00000357641.6	+	12	3635	c.3382G>A	c.(3382-3384)Gag>Aag	p.E1128K	BRPF3_ENST00000534400.1_Missense_Mutation_p.R1095K|BRPF3_ENST00000534694.1_Missense_Mutation_p.E794K|BRPF3_ENST00000543502.1_Missense_Mutation_p.E858K|BRPF3_ENST00000443324.2_Missense_Mutation_p.E794K|BRPF3_ENST00000339717.7_Missense_Mutation_p.E858K	NM_015695.2	NP_056510.2	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	1128	PWWP.				histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	40						GAAACAGGCAGAGGCTGGAGA	0.622000													9	26					0	0	1	0	0
GNAI1	2770	broad.mit.edu	37	7	79833069	79833069	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr7:79833069C>T	ENST00000351004.3	+	5	884	c.511C>T	c.(511-513)Caa>Taa	p.Q171*	GNAI1_ENST00000457358.2_Nonsense_Mutation_p.Q119*	NM_002069.5	NP_002060.4	P63096	GNAI1_HUMAN	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	171					cell cycle|cell division|inhibition of adenylate cyclase activity by G-protein signaling pathway|platelet activation|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody|nucleus	G-protein beta/gamma-subunit complex binding|GTP binding|metabotropic serotonin receptor binding|signal transducer activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	19						CATCCCGACTCAACAAGATGT	0.303000													15	45					0	0	1	0	0
CADPS	8618	broad.mit.edu	37	3	62535722	62535722	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:62535722C>T	ENST00000383710.4	-	11	2171	c.1822G>A	c.(1822-1824)Gat>Aat	p.D608N	CADPS_ENST00000357948.3_Missense_Mutation_p.D608N|CADPS_ENST00000283269.9_Missense_Mutation_p.D608N	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	608	PH.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		TCTTGTTCATCGTCACTGGCA	0.547000													20	70					0	0	1	0	0
PPARD	5467	broad.mit.edu	37	6	35392459	35392459	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:35392459C>T	ENST00000311565.4	+	8	1330	c.981C>T	c.(979-981)atC>atT	p.I327I	PPARD_ENST00000418635.2_Silent_p.I229I|PPARD_ENST00000337400.2_Silent_p.I327I|PPARD_ENST00000444397.1_Silent_p.I327I|PPARD_ENST00000360694.3_Silent_p.I327I|PPARD_ENST00000448077.2_Silent_p.I288I|PPARD_ENST00000540939.1_Silent_p.I224I	NM_001171818.1	NP_001165289.1	Q03181	PPARD_HUMAN	peroxisome proliferator-activated receptor delta	327	Ligand-binding.				apoptosis|axon ensheathment|cholesterol metabolic process|decidualization|embryo implantation|fatty acid beta-oxidation|fatty acid transport|generation of precursor metabolites and energy|glucose metabolic process|glucose transport|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|linoleic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(4)|liver(2)|lung(9)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23					Icosapent(DB00159)|Sulindac(DB00605)|Treprostinil(DB00374)	TCAGTGATATCATTGAGCCTA	0.532000													20	21					0	0	1	0	0
PPIP5K1	9677	broad.mit.edu	37	15	43831685	43831685	+	Missense_Mutation	SNP	G	G	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr15:43831685G>T	ENST00000420765.1	-	30	3664	c.3482C>A	c.(3481-3483)tCt>tAt	p.S1161Y	PPIP5K1_ENST00000381879.4_Missense_Mutation_p.S1137Y|PPIP5K1_ENST00000360301.4_Missense_Mutation_p.S1136Y|PPIP5K1_ENST00000348806.6_Missense_Mutation_p.S1094Y|PPIP5K1_ENST00000334933.4_Missense_Mutation_p.S1136Y|PPIP5K1_ENST00000396923.3_Missense_Mutation_p.S1161Y|PPIP5K1_ENST00000360135.4_Missense_Mutation_p.S1094Y|PPIP5K1_ENST00000381885.1_Missense_Mutation_p.S1157Y	NM_001130858.2	NP_001124330.1	Q6PFW1	VIP1_HUMAN	diphosphoinositol pentakisphosphate kinase 1	1161					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			large_intestine(1)	1						GGGCTTCTCAGAGCGCTGCTG	0.517000													6	9					1	1	1	1	0
ARID1B	57492	broad.mit.edu	37	6	157431689	157431689	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:157431689G>A	ENST00000346085.5	+	7	2366	c.2365G>A	c.(2365-2367)Gaa>Aaa	p.E789K	ARID1B_ENST00000350026.5_Missense_Mutation_p.E776K|RP1-137K2.2_ENST00000442936.1_RNA|ARID1B_ENST00000275248.4_Missense_Mutation_p.E718K|ARID1B_ENST00000367148.1_Missense_Mutation_p.E776K	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	776					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		AATGCCACAGGAAAGAGGTTC	0.512000													12	13					0	0	1	0	0
OR12D2	26529	broad.mit.edu	37	6	29364885	29364885	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:29364885C>T	ENST00000383555.2	+	1	470	c.409C>T	c.(409-411)Cag>Tag	p.Q137*	OR5V1_ENST00000377154.1_Intron	NM_013936.3	NP_039224.2	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)	137					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(20)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	31						CATGAACCCTCAGCTCTGTAC	0.522000													13	51					0	0	1	0	0
UBC	7316	broad.mit.edu	37	12	125397084	125397084	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:125397084C>G	ENST00000536769.1	-	1	2810	c.1234G>C	c.(1234-1236)Gac>Cac	p.D412H	UBC_ENST00000538617.1_Intron|UBC_ENST00000339647.5_Missense_Mutation_p.D412H|UBC_ENST00000546120.1_Missense_Mutation_p.D336H			P0CG48	UBC_HUMAN	ubiquitin C	412	Ubiquitin-like 6.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(3)|endometrium(4)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		CCTTCCTTGTCTTGGATCTTT	0.517000													76	134					0	0	1	0	0
EFEMP2	30008	broad.mit.edu	37	11	65638716	65638716	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:65638716G>A	ENST00000307998.6	-	4	509	c.279C>T	c.(277-279)ggC>ggT	p.G93G	EFEMP2_ENST00000528176.1_Silent_p.G93G	NM_016938.4	NP_058634.4	O95967	FBLN4_HUMAN	EGF containing fibulin-like extracellular matrix protein 2	93					blood coagulation	basement membrane|membrane	calcium ion binding|extracellular matrix structural constituent|protein binding|transmembrane receptor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21				READ - Rectum adenocarcinoma(159;0.169)		GGGGTCCCTCGCCGTGTAGGT	0.652000													29	86					0	0	1	0	0
ACTN4	81	broad.mit.edu	37	19	39214851	39214851	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:39214851G>A	ENST00000252699.2	+	15	1823	c.1747G>A	c.(1747-1749)Gag>Aag	p.E583K	ACTN4_ENST00000390009.3_Missense_Mutation_p.E364K|ACTN4_ENST00000424234.2_Missense_Mutation_p.E193K	NM_004924.4	NP_004915.2	O43707	ACTN4_HUMAN	actinin, alpha 4	583					platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|urinary_tract(3)	30	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CGCCGATAGGGAGCGCGAGGC	0.662000													5	57					0	0	1	0	0
HOXC9	3225	broad.mit.edu	37	12	54394285	54394285	+	Missense_Mutation	SNP	T	T	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:54394285T>A	ENST00000303450.4	+	1	383	c.313T>A	c.(313-315)Tcc>Acc	p.S105T	HOXC9_ENST00000504557.1_Intron|RP11-834C11.12_ENST00000513209.1_Intron|HOXC9_ENST00000508190.1_Missense_Mutation_p.S105T	NM_006897.1	NP_008828.1	P31274	HXC9_HUMAN	homeobox C9	105					multicellular organismal development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(3)|liver(1)|lung(5)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	14						CGGCGCCGTCTCCTTCCCCAG	0.736000													7	9					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238267223	238267223	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr2:238267223C>G	ENST00000295550.4	-	21	6864	c.6412G>C	c.(6412-6414)Gat>Cat	p.D2138H	COL6A3_ENST00000353578.4_Missense_Mutation_p.D1932H|COL6A3_ENST00000347401.3_Missense_Mutation_p.D1937H|COL6A3_ENST00000409809.1_Missense_Mutation_p.D1932H|COL6A3_ENST00000346358.4_Missense_Mutation_p.D1938H|COL6A3_ENST00000472056.1_Missense_Mutation_p.D1531H	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	2138	Collagen-like 2.|Triple-helical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GGTCCTTTATCACCCTAAAGA	0.398000													29	69					0	0	1	0	0
PCDH20	64881	broad.mit.edu	37	13	61987574	61987574	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr13:61987574C>G	ENST00000409186.1	-	5	2763	c.658G>C	c.(658-660)Gaa>Caa	p.E220Q	PCDH20_ENST00000409204.4_Missense_Mutation_p.E220Q			Q8N6Y1	PCD20_HUMAN	protocadherin 20	193	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(14)|liver(1)|lung(23)|ovary(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	58		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		GGTGCATTTTCCGGGACCCAC	0.517000													6	82					0	0	1	0	0
SFRP2	6423	broad.mit.edu	37	4	154702726	154702726	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr4:154702726C>T	ENST00000274063.4	-	3	1049	c.765G>A	c.(763-765)gcG>gcA	p.A255A		NM_003013.2	NP_003004.1	Q96HF1	SFRP2_HUMAN	secreted frizzled-related protein 2	255	NTR.				brain development|cardiac left ventricle morphogenesis|cell-cell signaling|dermatome development|hemopoietic stem cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|negative regulation of cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|outflow tract morphogenesis|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell adhesion mediated by integrin|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of fat cell differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of stem cell division|sclerotome development	cytoplasm|extracellular matrix|extracellular space|plasma membrane	fibronectin binding|integrin binding|PDZ domain binding|receptor agonist activity|Wnt receptor activity|Wnt-protein binding			breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(1)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	16	all_hematologic(180;0.093)	Renal(120;0.117)				CCAGATAGGGCGCGTTGATGT	0.567000													13	37					0	0	1	0	0
SCAMP4	113178	broad.mit.edu	37	19	1924122	1924122	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:1924122C>G	ENST00000316097.8	+	7	796	c.529C>G	c.(529-531)Cga>Gga	p.R177G	SCAMP4_ENST00000409472.1_Missense_Mutation_p.R143G|SCAMP4_ENST00000414057.2_3'UTR	NM_079834.2	NP_524558.1	Q969E2	SCAM4_HUMAN	secretory carrier membrane protein 4	177					protein transport	integral to membrane							Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGGATCTACCGAGGGGCTGG	0.622000													5	5					0	0	1	0	0
LMTK3	114783	broad.mit.edu	37	19	49012219	49012219	+	Missense_Mutation	SNP	A	A	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:49012219A>G	ENST00000600059.1	-	5	673	c.446T>C	c.(445-447)cTg>cCg	p.L149P	LMTK3_ENST00000270238.3_Missense_Mutation_p.L178P					lemur tyrosine kinase 3											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		AATCTCTCCCAGGATCACCTG	0.657000													4	51					0	0	1	0	0
SLMAP	7871	broad.mit.edu	37	3	57743490	57743490	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:57743490C>T	ENST00000383718.3	+	1	210	c.112C>T	c.(112-114)Cga>Tga	p.R38*	SLMAP_ENST00000449503.2_Nonsense_Mutation_p.R38*|SLMAP_ENST00000416870.1_5'UTR|SLMAP_ENST00000295952.3_Nonsense_Mutation_p.R38*|SLMAP_ENST00000428312.1_Nonsense_Mutation_p.R38*|SLMAP_ENST00000295951.3_Nonsense_Mutation_p.R38*			Q14BN4	SLMAP_HUMAN	sarcolemma associated protein	38	FHA.|Necessary for targeting to centrosomes (By similarity).				muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|urinary_tract(2)	18				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)		GGCCCGCTGTCGACCAGCGCA	0.547000													10	43					0	0	1	0	0
TXNRD2	10587	broad.mit.edu	37	22	19882961	19882961	+	Silent	SNP	C	C	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr22:19882961C>A	ENST00000400519.1	-	11	914	c.915G>T	c.(913-915)acG>acT	p.T305T	TXNRD2_ENST00000334363.9_Silent_p.T306T|TXNRD2_ENST00000491939.1_5'UTR|TXNRD2_ENST00000542719.1_Silent_p.T276T|TXNRD2_ENST00000400518.1_Silent_p.T276T|TXNRD2_ENST00000400521.1_Silent_p.T306T|TXNRD2_ENST00000535882.1_Silent_p.T305T			Q9NNW7	TRXR2_HUMAN	thioredoxin reductase 2	306					cell redox homeostasis|response to oxygen radical	mitochondrion	flavin adenine dinucleotide binding|NADP binding|thioredoxin-disulfide reductase activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|urinary_tract(2)	30	Colorectal(54;0.0993)					CAAAGGTGCCCGTGTCCTCCT	0.657000													31	81					1.57351e-24	1.72822e-24	1	1	0
DDB2	1643	broad.mit.edu	37	11	47236798	47236798	+	Silent	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:47236798C>G	ENST00000256996.4	+	1	306	c.111C>G	c.(109-111)ctC>ctG	p.L37L	DDB2_ENST00000378600.3_Silent_p.L37L|DDB2_ENST00000378603.3_Silent_p.L37L|DDB2_ENST00000378601.3_Silent_p.L37L	NM_000107.2	NP_000098.1	Q92466	DDB2_HUMAN	damage-specific DNA binding protein 2, 48kDa	37					nucleotide-excision repair, DNA damage removal|protein autoubiquitination|protein polyubiquitination|response to UV	nucleoplasm|protein complex	damaged DNA binding|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(1)	17						CCAAGAAGCTCTGTGCGAAGG	0.607000			"""Mis, N"""			"""skin basal cell, skin squamous cell, melanoma"""		Direct reversal of damage;Nucleotide excision repair (NER)	Xeroderma Pigmentosum				34	99					0	0	1	0	0
C5orf42	65250	broad.mit.edu	37	5	37187901	37187901	+	Silent	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr5:37187901G>C	ENST00000274258.7	-	22	4085	c.498C>G	c.(496-498)gtC>gtG	p.V166V	C5orf42_ENST00000425232.2_Silent_p.V1285V|C5orf42_ENST00000508244.1_Silent_p.V1285V			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	1285										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			ACTTATCACGGACATGCAGCA	0.343000													7	31					0	0	1	0	0
SESN3	143686	broad.mit.edu	37	11	94917686	94917686	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:94917686C>T	ENST00000536441.1	-	6	1171	c.835G>A	c.(835-837)Gaa>Aaa	p.E279K	RP11-712B9.2_ENST00000534864.1_RNA|SESN3_ENST00000278499.2_Missense_Mutation_p.E140K|SESN3_ENST00000393234.1_Missense_Mutation_p.E279K|RP11-712B9.2_ENST00000534891.1_RNA|SESN3_ENST00000416495.2_Missense_Mutation_p.E279K	NM_001271594.1|NM_144665.2	NP_001258523.1|NP_653266.2	P58005	SESN3_HUMAN	sestrin 3	279					cell cycle arrest	nucleus				endometrium(5)|large_intestine(6)|lung(3)|skin(1)|stomach(1)	16		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.234)		GACGCCTCTTCATCTTCCCTT	0.388000													30	43					0	0	1	0	0
ZNF671	79891	broad.mit.edu	37	19	58233695	58233695	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:58233695C>T	ENST00000317398.6	-	3	472	c.377G>A	c.(376-378)gGa>gAa	p.G126E	AC003006.7_ENST00000594684.1_Intron|AC003006.7_ENST00000599221.1_Intron|ZNF671_ENST00000594803.1_5'UTR|ZNF671_ENST00000596939.1_3'UTR|ZNF671_ENST00000335820.3_Missense_Mutation_p.G28E	NM_024833.2	NP_079109.2	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	126					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(6)|liver(1)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AGGTCTAAGTCCCCTCTGGGC	0.517000													58	110					0	0	1	0	0
LSG1	55341	broad.mit.edu	37	3	194362864	194362864	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:194362864C>T	ENST00000265245.5	-	14	2224	c.1910G>A	c.(1909-1911)tGg>tAg	p.W637*	AC046143.3_ENST00000447139.1_RNA	NM_018385.2	NP_060855.2	Q9H089	LSG1_HUMAN	large 60S subunit nuclear export GTPase 1	637					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity			breast(2)|endometrium(3)|large_intestine(2)|lung(9)	16	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		ATGTTTTTTCCAGGGCTTCCC	0.498000													8	85					0	0	1	0	0
PHLPP1	23239	broad.mit.edu	37	18	60625990	60625990	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr18:60625990G>A	ENST00000400316.4	+	13	3698	c.1917G>A	c.(1915-1917)ctG>ctA	p.L639L	PHLPP1_ENST00000262719.5_Silent_p.L1151L	NM_194449.3	NP_919431.2	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein phosphatase 1	1151					apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity			endometrium(2)|kidney(2)|lung(13)	17						TGGAACTACTGAAGTAAGTAT	0.438000													8	12					0	0	1	0	0
SYNGR2	9144	broad.mit.edu	37	17	76168047	76168047	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr17:76168047G>C	ENST00000588282.1	+	3	800	c.794G>C	c.(793-795)aGa>aCa	p.R265T	SYNGR2_ENST00000590201.1_3'UTR|SYNGR2_ENST00000585591.1_Intron|SYNGR2_ENST00000589711.1_3'UTR|SYNGR2_ENST00000592456.1_3'UTR|SYNGR2_ENST00000225777.3_3'UTR	NM_004710.3	NP_004701.1	O43760	SNG2_HUMAN	synaptogyrin 2	0						integral to plasma membrane				endometrium(2)|large_intestine(1)|liver(1)|lung(1)|skin(1)|urinary_tract(1)	7			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.0994)			GGGGGACAGAGAGGGCCCTCC	0.627000													11	38					0	0	1	0	0
ITPR3	3710	broad.mit.edu	37	6	33638553	33638553	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:33638553G>A	ENST00000374316.5	+	21	3607	c.2547G>A	c.(2545-2547)gtG>gtA	p.V849V	ITPR3_ENST00000605930.1_Silent_p.V849V			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	849					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						GCGAGGCCGTGCCCTTTGCCA	0.572000													19	73					0	0	1	0	0
TRAPPC10	7109	broad.mit.edu	37	21	45497582	45497582	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr21:45497582C>T	ENST00000291574.4	+	11	1561	c.1386C>T	c.(1384-1386)tcC>tcT	p.S462S		NM_003274.4	NP_003265.3	P48553	TPC10_HUMAN	trafficking protein particle complex 10	462					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(8)|ovary(1)|prostate(2)|skin(2)|urinary_tract(4)	41						AGGATTTGTCCCATGCCACCA	0.348000													26	79					0	0	1	0	0
INTS1	26173	broad.mit.edu	37	7	1527585	1527585	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr7:1527585G>A	ENST00000389470.4	-	20	2710	c.2711C>T	c.(2710-2712)tCc>tTc	p.S904F	INTS1_ENST00000404767.3_Missense_Mutation_p.S776F			Q8N201	INT1_HUMAN	integrator complex subunit 1	776					snRNA processing	integral to membrane|integrator complex|nuclear membrane				autonomic_ganglia(1)|cervix(1)|endometrium(14)|kidney(3)|large_intestine(7)|lung(24)|ovary(1)|prostate(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	62		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		CGGTGGGTAGGAGTAGTTGCT	0.647000													77	65					0	0	1	0	0
PUF60	22827	broad.mit.edu	37	8	144898988	144898988	+	Splice_Site	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr8:144898988G>C	ENST00000526683.1	-	12	1937	c.1382C>G	c.(1381-1383)tCt>tGt	p.S461C	PUF60_ENST00000313352.7_Splice_Site_p.S401C|PUF60_ENST00000453551.2_Splice_Site_p.S418C|PUF60_ENST00000527197.1_Splice_Site_p.S415C|PUF60_ENST00000456095.2_Splice_Site_p.S432C|PUF60_ENST00000349157.6_Splice_Site_p.S444C	NM_001271098.1|NM_078480.2	NP_001258027.1|NP_510965.1	Q9UHX1	PUF60_HUMAN	poly-U binding splicing factor 60KDa	461	Inhibits homodimerization.|Inhibits transcriptional repression, interaction with ERCC3 and apoptosis induction.				apoptosis|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleus|ribonucleoprotein complex	DNA binding|nucleotide binding|protein binding|RNA binding			NS(1)|endometrium(1)|kidney(3)|lung(7)|prostate(2)	14	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CATCACTGTAGACTGTGGGGC	0.647000													34	41					0	0	1	0	0
TOP2A	7153	broad.mit.edu	37	17	38555186	38555186	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr17:38555186G>C	ENST00000423485.1	-	26	3450	c.3292C>G	c.(3292-3294)Cca>Gca	p.P1098A		NM_001067.3	NP_001058.2	P11388	TOP2A_HUMAN	topoisomerase (DNA) II alpha 170kDa	1098					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(9)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	39		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	TCTTCATCTGGAACCTAAAGG	0.328000													3	88					0	0	1	0	0
ATP6V1B1	525	broad.mit.edu	37	2	71189919	71189919	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr2:71189919C>T	ENST00000234396.4	+	9	871	c.798C>T	c.(796-798)atC>atT	p.I266I	ATP6V1B1_ENST00000412314.1_Silent_p.I266I|AC007040.11_ENST00000606025.1_Intron	NM_001692.3	NP_001683.2	P15313	VATB1_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1	266					ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|prostate(1)|skin(1)	19						TCGAGCGGATCATCACCCCGC	0.582000													11	59					0	0	1	0	0
UBC	7316	broad.mit.edu	37	12	125396369	125396369	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:125396369C>T	ENST00000536769.1	-	1	3525	c.1949G>A	c.(1948-1950)aGg>aAg	p.R650K	UBC_ENST00000538617.1_Missense_Mutation_p.R270K|UBC_ENST00000339647.5_Missense_Mutation_p.R650K|UBC_ENST00000546120.1_Missense_Mutation_p.R574K			P0CG48	UBC_HUMAN	ubiquitin C	650	Ubiquitin-like 9.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(3)|endometrium(4)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		AAAGATCAACCTCTGCTGATC	0.532000													68	108					0	0	1	0	0
SETDB1	9869	broad.mit.edu	37	1	150919449	150919449	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:150919449G>C	ENST00000271640.5	+	10	1418	c.1228G>C	c.(1228-1230)Gag>Cag	p.E410Q	SETDB1_ENST00000459773.1_Intron|SETDB1_ENST00000368969.4_Missense_Mutation_p.E410Q	NM_001145415.1|NM_012432.3	NP_001138887.1|NP_036564.3	Q15047	SETB1_HUMAN	SET domain, bifurcated 1	410					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			NS(1)|large_intestine(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTCTGCACTGGAGAAGAAGCA	0.488000													14	51					0	0	1	0	0
PDAP1	11333	broad.mit.edu	37	7	98998030	98998030	+	Silent	SNP	A	A	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr7:98998030A>G	ENST00000350498.3	-	4	511	c.231T>C	c.(229-231)gtT>gtC	p.V77V		NM_014891.6	NP_055706.1	Q13442	HAP28_HUMAN	PDGFA associated protein 1	77					cell proliferation|signal transduction					breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|ovary(2)|prostate(1)|skin(1)	9	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)		Becaplermin(DB00102)	TGAGCCCTTCAACGCCTTTGC	0.567000													7	187					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22939106	22939106	+	Silent	SNP	A	A	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:22939106A>G	ENST00000397104.3	-	8	3014	c.3015T>C	c.(3013-3015)acT>acC	p.T1005T						zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TTTTCCCTCCAGTATGAATTG	0.373000													31	64					0	0	1	0	0
ABHD8	79575	broad.mit.edu	37	19	17403522	17403522	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:17403522G>A	ENST00000247706.3	-	5	1507	c.1268C>T	c.(1267-1269)tCg>tTg	p.S423L	MRPL34_ENST00000600434.1_5'UTR|MRPL34_ENST00000595444.1_Missense_Mutation_p.E25K	NM_024527.4	NP_078803.4	Q96I13	ABHD8_HUMAN	abhydrolase domain containing 8	423							hydrolase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(5)|urinary_tract(1)	9						AGCCTTGGGCGAGGGCTCGGG	0.652000													3	7					0	0	1	0	0
IMPG2	50939	broad.mit.edu	37	3	101010336	101010336	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:101010336C>G	ENST00000193391.7	-	4	707	c.520G>C	c.(520-522)Gaa>Caa	p.E174Q		NM_016247.3	NP_057331.2	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	174					visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			NS(1)|breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(14)|lung(32)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						CTTACAGTTTCCTTTGCATAA	0.343000													12	16					0	0	1	0	0
LRG1	116844	broad.mit.edu	37	19	4538393	4538393	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:4538393C>G	ENST00000306390.6	-	2	1063	c.603G>C	c.(601-603)gaG>gaC	p.E201D	CTB-50L17.14_ENST00000586020.1_Intron	NM_052972.2	NP_443204.1	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1	201						extracellular region|membrane				NS(1)|endometrium(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	13		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGGCAAGGTCTCCAACTGGT	0.582000													66	182					0	0	1	0	0
CCNE1	898	broad.mit.edu	37	19	30313232	30313232	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:30313232C>T	ENST00000262643.3	+	10	1205	c.926C>T	c.(925-927)tCa>tTa	p.S309L	CCNE1_ENST00000357943.5_Missense_Mutation_p.S266L|CCNE1_ENST00000444983.2_Missense_Mutation_p.S294L	NM_001238.2	NP_001229.1	P24864	CCNE1_HUMAN	cyclin E1	309					androgen receptor signaling pathway|cell division|positive regulation of transcription, DNA-dependent|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm	androgen receptor binding|protein kinase binding|transcription coactivator activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(12)|skin(1)	20	all_cancers(1;2.19e-31)|all_epithelial(1;1.49e-30)|all_lung(1;1.37e-11)|Lung NSC(1;2.35e-11)|Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|Epithelial(1;6.85e-98)|all cancers(1;1.38e-94)|OV - Ovarian serous cystadenocarcinoma(1;1.38e-90)|STAD - Stomach adenocarcinoma(5;5.8e-07)|GBM - Glioblastoma multiforme(4;0.0394)|Lung(7;0.092)|LUAD - Lung adenocarcinoma(5;0.115)|BRCA - Breast invasive adenocarcinoma(6;0.183)|COAD - Colon adenocarcinoma(1;0.188)|Colorectal(1;0.202)			CATTTCTCGTCATCTGAATTG	0.433000			A		serous ovarian								45	98					0	0	1	0	0
HSPA12B	116835	broad.mit.edu	37	20	3726592	3726592	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr20:3726592G>C	ENST00000254963.2	+	7	734	c.589G>C	c.(589-591)Gag>Cag	p.E197Q	HSPA12B_ENST00000542646.1_Missense_Mutation_p.E31Q	NM_001197327.1|NM_052970.4	NP_001184256.1|NP_443202.3	Q96MM6	HS12B_HUMAN	heat shock 70kD protein 12B	197							ATP binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	14						ATCGCTGCCAGAGAAGGACAC	0.627000													24	53					0	0	1	0	0
MAD2L1	4085	broad.mit.edu	37	4	120983232	120983232	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr4:120983232G>A	ENST00000296509.6	-	3	578	c.239C>T	c.(238-240)tCa>tTa	p.S80L		NM_002358.3	NP_002349.1	Q13257	MD2L1_HUMAN	MAD2 mitotic arrest deficient-like 1 (yeast)		HORMA.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of apoptosis|negative regulation of mitotic anaphase-promoting complex activity|positive regulation of mitotic cell cycle spindle assembly checkpoint	condensed chromosome kinetochore|cytosol|nucleus|perinuclear region of cytoplasm	protein homodimerization activity			breast(2)|kidney(2)|large_intestine(2)|lung(3)	9						TTTCTGAACTGAACACTTGTA	0.413000													8	27					0	0	1	0	0
CARHSP1	23589	broad.mit.edu	37	16	8952322	8952322	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr16:8952322G>A	ENST00000396593.2	-	3	525	c.166C>T	c.(166-168)Cgg>Tgg	p.R56W	RP11-77H9.2_ENST00000565934.1_RNA|CARHSP1_ENST00000562843.1_Missense_Mutation_p.R56W|CARHSP1_ENST00000561530.1_Missense_Mutation_p.R56W|CARHSP1_ENST00000567554.1_Missense_Mutation_p.R56W|CARHSP1_ENST00000311052.5_Missense_Mutation_p.R56W	NM_001042476.1|NM_001278260.1|NM_001278261.1|NM_001278262.1|NM_001278263.1|NM_001278264.1|NM_001278265.1|NM_001278266.1|NM_014316.3	NP_001035941.1|NP_001265189.1|NP_001265190.1|NP_001265191.1|NP_001265192.1|NP_001265193.1|NP_001265194.1|NP_001265195.1|NP_055131.2	Q9Y2V2	CHSP1_HUMAN	calcium regulated heat stable protein 1, 24kDa	56					intracellular signal transduction|regulation of mRNA stability|regulation of transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|P granule	DNA binding|mRNA 3'-UTR binding|phosphatase binding			endometrium(2)|lung(1)	3						TGTGAAGCCCGCACCGTCCTG	0.612000													4	22					0	0	1	0	0
MS4A8	83661	broad.mit.edu	37	11	60474494	60474494	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:60474494G>A	ENST00000300226.2	+	4	579	c.376G>A	c.(376-378)Gaa>Aaa	p.E126K		NM_031457.1	NP_113645.1			membrane-spanning 4-domains, subfamily A, member 8																		CGTGGCAGCAGAAAATCAGCC	0.473000													84	75					0	0	1	0	0
HIST1H2BG	8339	broad.mit.edu	37	6	26216733	26216733	+	Nonsense_Mutation	SNP	T	T	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:26216733T>A	ENST00000244601.3	-	1	139	c.139A>T	c.(139-141)Aaa>Taa	p.K47*		NM_003518.3	NP_003509.1	P62807	H2B1C_HUMAN	histone cluster 1, H2bg	47					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	8		all_hematologic(11;0.196)				TGAACCTGTTTTAGCACCTTG	0.537000													33	128					0	0	1	0	0
NUP210L	91181	broad.mit.edu	37	1	154018770	154018770	+	Missense_Mutation	SNP	T	T	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:154018770T>C	ENST00000368559.3	-	26	3630	c.3559A>G	c.(3559-3561)Acc>Gcc	p.T1187A	NUP210L_ENST00000271854.3_Missense_Mutation_p.T1187A|NUP210L_ENST00000368553.1_Missense_Mutation_p.T120A	NM_207308.2	NP_997191.2	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like	1187						integral to membrane				NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|lung(34)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|urinary_tract(2)	80	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			CTGACCTTGGTAGCTGTGATG	0.458000													34	40					0	0	1	0	0
BCAM	4059	broad.mit.edu	37	19	45315573	45315573	+	Missense_Mutation	SNP	G	G	A	rs144124876	byFrequency	TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:45315573G>A	ENST00000589651.1	+	3	412	c.358G>A	c.(358-360)Gag>Aag	p.E120K	BCAM_ENST00000270233.6_Missense_Mutation_p.E120K			P50895	BCAM_HUMAN	basal cell adhesion molecule (Lutheran blood group)		Ig-like V-type 1.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	22	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				GGTGGGCGACGAGCGAGACTA	0.682000													13	17					0	0	1	0	0
RNF219	79596	broad.mit.edu	37	13	79233216	79233216	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr13:79233216G>A	ENST00000282003.6	-	1	98	c.40C>T	c.(40-42)Ctg>Ttg	p.L14L		NM_024546.3	NP_078822.3	Q5W0B1	RN219_HUMAN	ring finger protein 219	14							zinc ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|liver(1)|lung(11)|prostate(1)|skin(1)	32		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.0414)		GTGATGGGCAGAGTGAGCGAC	0.587000													14	33					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73071582	73071582	+	RNA	SNP	A	A	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chrX:73071582A>G	ENST00000429829.1	-	0	1006					NR_001564.2																						ACCTGCTATCATCCATCTTGC	0.458000													15	31					0	0	1	0	0
EMC10	284361	broad.mit.edu	37	19	50982320	50982320	+	Silent	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:50982320C>G	ENST00000376918.3	+	3	340	c.294C>G	c.(292-294)ctC>ctG	p.L98L	EMC10_ENST00000598585.1_Silent_p.L98L|EMC10_ENST00000334976.6_Silent_p.L98L	NM_175063.4	NP_778233.4			ER membrane protein complex subunit 10																		GGGGCCGACTCCGGGTGAGGT	0.667000													5	14					0	0	1	0	0
NCOA1	8648	broad.mit.edu	37	2	24933875	24933875	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr2:24933875G>A	ENST00000405141.1	+	15	3205	c.2494G>A	c.(2494-2496)Gag>Aag	p.E832K	NCOA1_ENST00000348332.3_Missense_Mutation_p.E832K|NCOA1_ENST00000538539.1_Missense_Mutation_p.E832K|NCOA1_ENST00000395856.3_Missense_Mutation_p.E832K|NCOA1_ENST00000406961.1_Missense_Mutation_p.E832K|NCOA1_ENST00000407230.1_Missense_Mutation_p.E681K|NCOA1_ENST00000288599.5_Missense_Mutation_p.E832K			Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1	832	Interaction with CREBBP.								PAX3/NCOA1(8)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(26)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	53	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGCTTATGTGAGACAGACAG	0.517000			T	PAX3	alveolar rhadomyosarcoma								11	46					0	0	1	0	0
TTI1	9675	broad.mit.edu	37	20	36631084	36631084	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr20:36631084C>T	ENST00000373448.2	-	5	2836	c.2598G>A	c.(2596-2598)gtG>gtA	p.V866V	TTI1_ENST00000449821.1_Silent_p.V866V|TTI1_ENST00000373447.3_Silent_p.V866V	NM_014657.1	NP_055472.1	O43156	TTI1_HUMAN	TELO2 interacting protein 1	866							binding			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						AGCGTTCCATCACGTCCATGG	0.512000													20	95					0	0	1	0	0
PLEKHG6	55200	broad.mit.edu	37	12	6436606	6436606	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:6436606C>T	ENST00000449001.2	+	14	2255	c.1761C>T	c.(1759-1761)ctC>ctT	p.L587L	PLEKHG6_ENST00000396988.3_Silent_p.L619L|PLEKHG6_ENST00000304581.8_Silent_p.L149L|PLEKHG6_ENST00000011684.7_Silent_p.L619L	NM_001144857.1	NP_001138329.1	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	619					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(4)	23						ACCCTCGCCTCACCTTCTCCA	0.677000													5	71					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40384158	40384158	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:40384158C>T	ENST00000221347.6	-	21	9459	c.9452G>A	c.(9451-9453)tGc>tAc	p.C3151Y		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	3151	TIL 7.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GTTTTCTGGGCAGGTGATCTC	0.607000													4	134					0	0	1	0	0
GTF2I	2969	broad.mit.edu	37	7	74160221	74160221	+	Splice_Site	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr7:74160221G>A	ENST00000324896.4	+	22	2323		c.e22-1		GTF2I_ENST00000353920.4_Splice_Site|GTF2I_ENST00000346152.4_Splice_Site|GTF2I_ENST00000416070.1_Splice_Site|GTF2I_ENST00000438130.2_Splice_Site	NM_032999.2	NP_127492.1	P78347	GTF2I_HUMAN	general transcription factor IIi						negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19						TTTCTTTCTAGACCTGAACTA	0.428000													15	76					0	0	1	0	0
ENO2	2026	broad.mit.edu	37	12	7025642	7025642	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:7025642G>A	ENST00000535366.1	+	2	773	c.147G>A	c.(145-147)ctG>ctA	p.L49L	ENO2_ENST00000229277.1_Silent_p.L49L|ENO2_ENST00000538763.1_Silent_p.L49L|ENO2_ENST00000544774.1_Silent_p.L49L|ENO2_ENST00000545045.2_Silent_p.L49L|ENO2_ENST00000541477.1_Silent_p.L49L			P09104	ENOG_HUMAN	enolase 2 (gamma, neuronal)	49					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex|plasma membrane	magnesium ion binding|phosphopyruvate hydratase activity			endometrium(3)|large_intestine(2)|lung(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10						CCCTGGAGCTGAGGGATGGAG	0.557000													10	14					0	0	1	0	0
SLC8B1	80024	broad.mit.edu	37	12	113756852	113756852	+	Missense_Mutation	SNP	T	T	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:113756852T>C	ENST00000552014.1	-	9	1234	c.719A>G	c.(718-720)tAt>tGt	p.Y240C	SLC8B1_ENST00000202831.3_Missense_Mutation_p.Y240C|SLC8B1_ENST00000546737.1_Missense_Mutation_p.Y184C|SLC8B1_ENST00000553238.1_5'UTR					solute carrier family 8 (sodium/lithium/calcium exchanger), member B1	240																	AGTGACCACATAGAACACATA	0.542000													11	34					0	0	1	0	0
RAD51	5888	broad.mit.edu	37	15	40998452	40998452	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr15:40998452G>C	ENST00000267868.3	+	4	571	c.303G>C	c.(301-303)caG>caC	p.Q101H	RAD51_ENST00000382643.3_Intron|RAD51_ENST00000557850.1_Intron|RAD51_ENST00000423169.2_Missense_Mutation_p.Q101H|RAD51_ENST00000532743.1_Intron	NM_002875.4	NP_002866.2	Q06609	RAD51_HUMAN	RAD51 recombinase	101					DNA recombinase assembly|DNA unwinding involved in replication|mitotic recombination|positive regulation of DNA ligation|protein homooligomerization|reciprocal meiotic recombination	mitochondrial matrix|nucleus|perinuclear region of cytoplasm|PML body	ATP binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|protein C-terminus binding|single-stranded DNA binding|single-stranded DNA-dependent ATPase activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(1)|ovary(1)	9		all_cancers(109;1.19e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.45e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000421)|COAD - Colon adenocarcinoma(120;0.163)		AGATCATACAGATTACTACTG	0.398000								Homologous recombination					8	73					0	0	1	0	0
KDM6A	7403	broad.mit.edu	37	X	44938405	44938405	+	Missense_Mutation	SNP	T	T	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chrX:44938405T>C	ENST00000377967.4	+	20	2994	c.2953T>C	c.(2953-2955)Tct>Cct	p.S985P	KDM6A_ENST00000382899.4_Missense_Mutation_p.S992P|KDM6A_ENST00000536777.1_Missense_Mutation_p.S940P|KDM6A_ENST00000543216.1_Missense_Mutation_p.S906P	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	985					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						GGGACTTTTCTCTACTAAAAC	0.338000			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								40	7					0	0	1	0	0
HIST1H4I	8294	broad.mit.edu	37	6	27107381	27107381	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:27107381C>T	ENST00000354348.2	+	1	306	c.294C>T	c.(292-294)ctC>ctT	p.L98L	HIST1H2BK_ENST00000396891.4_Intron	NM_003495.2	NP_003486.1	P62805	H4_HUMAN	histone cluster 1, H4i	98					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			lung(1)	1						GCCGCACCCTCTATGGCTTCG	0.562000			T	BCL6	NHL								12	38					0	0	1	0	0
MRS2	57380	broad.mit.edu	37	6	24418733	24418733	+	Missense_Mutation	SNP	G	G	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:24418733G>T	ENST00000378386.3	+	9	1127	c.1034G>T	c.(1033-1035)gGa>gTa	p.G345V	MRS2_ENST00000535061.1_Missense_Mutation_p.G295V|MRS2_ENST00000443868.2_Missense_Mutation_p.G348V|MRS2_ENST00000543597.1_Missense_Mutation_p.G54V|MRS2_ENST00000378353.1_Missense_Mutation_p.G345V|MRS2_ENST00000483634.1_3'UTR|MRS2_ENST00000274747.7_3'UTR	NM_020662.2	NP_065713.1	Q9HD23	MRS2_HUMAN	MRS2 magnesium transporter	345					ion transport	integral to membrane|mitochondrial inner membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)|stomach(1)	12						CTGACCATGGGAACCTTCTCT	0.418000													39	99					2.26627e-22	2.47722e-22	1	1	0
FSIP1	161835	broad.mit.edu	37	15	40057905	40057905	+	Missense_Mutation	SNP	G	G	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr15:40057905G>T	ENST00000350221.3	-	4	562	c.353C>A	c.(352-354)gCt>gAt	p.A118D		NM_152597.4	NP_689810.3	Q8NA03	FSIP1_HUMAN	fibrous sheath interacting protein 1	118										NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(4)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	23		all_cancers(109;2.66e-19)|all_epithelial(112;2.66e-16)|Lung NSC(122;1.5e-11)|all_lung(180;4.03e-10)|Melanoma(134;0.0575)|Ovarian(310;0.0827)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;8.22e-06)|BRCA - Breast invasive adenocarcinoma(123;0.142)		CTTCTGAATAGCATCTTGAAG	0.284000													12	38					1.08611e-07	1.14353e-07	1	1	0
CYP7A1	1581	broad.mit.edu	37	8	59404161	59404161	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr8:59404161G>C	ENST00000301645.3	-	6	1525	c.1388C>G	c.(1387-1389)tCt>tGt	p.S463C		NM_000780.3	NP_000771.2	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A, polypeptide 1	463					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(1)|urinary_tract(1)	34		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				TTCAAAATAAGAAAGCATCAG	0.423000									Neonatal Giant Cell Hepatitis				10	97					0	0	1	0	0
MADD	8567	broad.mit.edu	37	11	47308081	47308081	+	Silent	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:47308081G>C	ENST00000342922.4	+	15	3006	c.2649G>C	c.(2647-2649)ctG>ctC	p.L883L	MADD_ENST00000407859.3_Silent_p.L840L|MADD_ENST00000311027.5_Silent_p.L883L|MADD_ENST00000402192.2_Silent_p.L883L|MADD_ENST00000349238.3_Silent_p.L883L|MADD_ENST00000395344.3_Silent_p.L840L|MADD_ENST00000406482.1_Silent_p.L840L|MADD_ENST00000395336.3_Silent_p.L883L|MADD_ENST00000402799.1_Silent_p.L840L	NM_130470.2	NP_569826.2	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain	883					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			breast(7)|central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(19)|lung(26)|ovary(6)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	84				Lung(87;0.182)		TCCCCAGTCTGAAAGGTAACT	0.547000													10	26					0	0	1	0	0
LRRTM3	347731	broad.mit.edu	37	10	68687405	68687405	+	Missense_Mutation	SNP	T	T	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr10:68687405T>A	ENST00000361320.4	+	2	1309	c.731T>A	c.(730-732)aTa>aAa	p.I244K	CTNNA3_ENST00000433211.2_Intron|CTNNA3_ENST00000373744.4_Intron	NM_178011.3	NP_821079.3	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	244						integral to membrane				breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	41						ATCAGTGTCATAGGACAGACC	0.468000													22	70					0	0	1	0	0
EXOC1	55763	broad.mit.edu	37	4	56757480	56757480	+	Splice_Site	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr4:56757480G>C	ENST00000381295.2	+	13	1887		c.e13-1		EXOC1_ENST00000349598.6_Splice_Site|EXOC1_ENST00000346134.7_Splice_Site	NM_001024924.1	NP_001020095.1	Q9NV70	EXOC1_HUMAN	exocyst complex component 1						exocytosis|protein transport	exocyst	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	35	Glioma(25;0.08)|all_neural(26;0.101)					GTTTTCTTCAGATCTTTGAAC	0.378000													13	22					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151849976	151849976	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr7:151849976C>T	ENST00000355193.2	-	50	12729	c.12511G>A	c.(12511-12513)Gag>Aag	p.E4171K	KMT2C_ENST00000262189.6_Missense_Mutation_p.E4114K|KMT2C_ENST00000485241.1_5'UTR					lysine (K)-specific methyltransferase 2C																		CTGCTAACCTCATAGCTGTTA	0.478000													39	66					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48256528	48256528	+	Missense_Mutation	SNP	A	A	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr16:48256528A>T	ENST00000394747.1	-	5	1107	c.758T>A	c.(757-759)aTa>aAa	p.I253K	ABCC11_ENST00000394748.1_Missense_Mutation_p.I253K|ABCC11_ENST00000537808.1_Missense_Mutation_p.I253K|ABCC11_ENST00000353782.5_Missense_Mutation_p.I253K|ABCC11_ENST00000356608.2_Missense_Mutation_p.I253K	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	253	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GGTGATGTGTATTACAGACTT	0.527000													32	41					0	0	1	0	0
ZBTB32	27033	broad.mit.edu	37	19	36207469	36207469	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:36207469C>T	ENST00000392197.2	+	7	1597	c.1279C>T	c.(1279-1281)Ccg>Tcg	p.P427S	ZBTB32_ENST00000262630.3_Missense_Mutation_p.P427S			Q9Y2Y4	ZBT32_HUMAN	zinc finger and BTB domain containing 32	427					DNA repair|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			large_intestine(5)|lung(1)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	14	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CGGGGCCGCTCCGTACCGCTG	0.687000											OREG0025433	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	50					0	0	1	0	0
BAK1	578	broad.mit.edu	37	6	33543646	33543646	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:33543646G>A	ENST00000374467.3	-	3	378	c.130C>T	c.(130-132)Cag>Tag	p.Q44*	BAK1_ENST00000442998.2_Nonsense_Mutation_p.Q44*|BAK1_ENST00000360661.5_Nonsense_Mutation_p.Q44*	NM_001188.3	NP_001179.1	Q16611	BAK_HUMAN	BCL2-antagonist/killer 1	44					activation of pro-apoptotic gene products|cellular response to mechanical stimulus|cellular response to UV|establishment or maintenance of transmembrane electrochemical gradient|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|release of cytochrome c from mitochondria	integral to mitochondrial outer membrane|pore complex	metal ion binding|protein heterodimerization activity			large_intestine(1)|lung(1)|ovary(1)|skin(1)	4						TGTTCCTGCTGATGGCGGTAA	0.602000													25	63					0	0	1	0	0
ITGAE	3682	broad.mit.edu	37	17	3664376	3664376	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr17:3664376G>A	ENST00000263087.4	-	6	627	c.529C>T	c.(529-531)Cgc>Tgc	p.R177C		NM_002208.4	NP_002199.3	P38570	ITAE_HUMAN	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	177	X-domain (extra domain).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		AGAGCCCGGCGCTGCCTGGCT	0.557000													95	48					0	0	1	0	0
MAP3K15	389840	broad.mit.edu	37	X	19443801	19443801	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chrX:19443801C>T	ENST00000338883.4	-	9	1286	c.1287G>A	c.(1285-1287)cgG>cgA	p.R429R	MAP3K15_ENST00000518578.1_5'UTR|MAP3K15_ENST00000359173.3_5'UTR|MAP3K15_ENST00000469203.2_Silent_p.R261R	NM_001001671.3	NP_001001671.3	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase 15	429							ATP binding|MAP kinase kinase kinase activity|metal ion binding			NS(2)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(13)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	Hepatocellular(33;0.183)					AACTGTTCAGCCGGACACCTT	0.408000													17	1					0	0	1	0	0
TANC2	26115	broad.mit.edu	37	17	61176545	61176545	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr17:61176545C>G	ENST00000424789.2	+	3	153	c.149C>G	c.(148-150)tCc>tGc	p.S50C	TANC2_ENST00000389520.4_Missense_Mutation_p.S50C	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	50							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						GGTGGCATCTCCACAGAAAGC	0.473000													9	9					0	0	1	0	0
GJB7	375519	broad.mit.edu	37	6	87994304	87994304	+	Silent	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:87994304G>C	ENST00000525899.1	-	3	672	c.327C>G	c.(325-327)ctC>ctG	p.L109L	GJB7_ENST00000296882.3_Silent_p.L109L	NM_198568.2	NP_940970.1	Q6PEY0	CXB7_HUMAN	gap junction protein, beta 7, 25kDa	109					cell communication	connexon complex|integral to membrane				endometrium(2)|large_intestine(3)	5		all_cancers(76;1.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;7.38e-10)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00323)		BRCA - Breast invasive adenocarcinoma(108;0.0167)		GGCTGACATAGAGTTTCTTTC	0.418000													31	38					0	0	1	0	0
SULF2	55959	broad.mit.edu	37	20	46313304	46313304	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr20:46313304C>T	ENST00000359930.4	-	6	1610	c.759G>A	c.(757-759)gcG>gcA	p.A253A	CTD-2653D5.1_ENST00000526566.2_RNA|SULF2_ENST00000484875.1_Silent_p.A253A|SULF2_ENST00000361612.4_Silent_p.A253A|SULF2_ENST00000467815.1_Silent_p.A253A	NM_018837.3	NP_061325.1	Q8IWU5	SULF2_HUMAN	sulfatase 2	253					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	54						CCGGGTTGGGCGCGTAGTTGT	0.632000													3	24					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141072590	141072590	+	Missense_Mutation	SNP	C	C	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr2:141072590C>A	ENST00000389484.3	-	83	13690	c.12719G>T	c.(12718-12720)tGg>tTg	p.W4240L		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4240	EGF-like 10.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.W4240*(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATAACTGGGCCAACAGTGACA	0.378000										TSP Lung(27;0.18)			8	81					1.12685e-05	1.16764e-05	1	1	0
PTPRZ1	5803	broad.mit.edu	37	7	121674148	121674148	+	Splice_Site	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr7:121674148G>C	ENST00000393386.2	+	16	5577		c.e16-1		PTPRZ1_ENST00000449182.1_Intron	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1						central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						TCCCTCATTAGACACTGAAAG	0.303000													11	31					0	0	1	0	0
IGF2R	3482	broad.mit.edu	37	6	160468305	160468305	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:160468305G>A	ENST00000356956.1	+	16	2314	c.2166G>A	c.(2164-2166)ccG>ccA	p.P722P		NM_000876.2	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor	722					receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			breast(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(27)|lung(31)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		GACACACACCGAGAGCTACGC	0.493000													8	39					0	0	1	0	0
EIF4G1	1981	broad.mit.edu	37	3	184049082	184049082	+	Missense_Mutation	SNP	G	G	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:184049082G>T	ENST00000342981.4	+	28	4607	c.4193G>T	c.(4192-4194)cGa>cTa	p.R1398L	EIF4G1_ENST00000434061.2_Missense_Mutation_p.R1202L|EIF4G1_ENST00000319274.6_Missense_Mutation_p.R1397L|EIF2B5_ENST00000444495.1_Intron|EIF4G1_ENST00000352767.3_Missense_Mutation_p.R1404L|EIF4G1_ENST00000435046.2_Missense_Mutation_p.R1201L|EIF4G1_ENST00000414031.1_Missense_Mutation_p.R1357L|EIF4G1_ENST00000441154.1_Missense_Mutation_p.R1234L|EIF4G1_ENST00000424196.1_Missense_Mutation_p.R1404L|EIF4G1_ENST00000350481.5_Missense_Mutation_p.R1233L|EIF4G1_ENST00000382330.3_Missense_Mutation_p.R1404L|EIF4G1_ENST00000411531.1_Missense_Mutation_p.R1358L|EIF4G1_ENST00000427845.1_Missense_Mutation_p.R1311L|EIF4G1_ENST00000392537.2_Missense_Mutation_p.R1310L|EIF4G1_ENST00000346169.2_Missense_Mutation_p.R1397L	NM_182917.4	NP_886553	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4 gamma, 1	1397					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(5)|large_intestine(14)|lung(41)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	75	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			ACGCTGTGGCGAGAAGCCGGG	0.517000													36	137					7.04047e-22	7.67747e-22	1	1	0
ZNF671	79891	broad.mit.edu	37	19	58232608	58232608	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:58232608C>T	ENST00000317398.6	-	4	941	c.846G>A	c.(844-846)caG>caA	p.Q282Q	AC003006.7_ENST00000594684.1_Intron|AC003006.7_ENST00000599221.1_Intron|ZNF671_ENST00000335820.3_Silent_p.Q184Q	NM_024833.2	NP_079109.2	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	282					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(6)|liver(1)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TGTGATACCTCTGTCCCATGA	0.512000													28	58					0	0	1	0	0
SNX3	8724	broad.mit.edu	37	6	108533427	108533427	+	Missense_Mutation	SNP	G	G	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:108533427G>T	ENST00000230085.8	-	4	753	c.415C>A	c.(415-417)Cgt>Agt	p.R139S	SNX3_ENST00000426155.2_Missense_Mutation_p.R107S|SNX3_ENST00000349379.5_Missense_Mutation_p.R117S	NM_003795.4	NP_003786.1	O60493	SNX3_HUMAN	sorting nexin 3	139	PX.				cell communication|endocytosis|protein transport	early endosome|endosome membrane	phosphatidylinositol-3-phosphate binding|protein phosphatase binding			large_intestine(1)	1		all_cancers(87;3.82e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000195)|Colorectal(196;0.0293)|all_lung(197;0.0938)		BRCA - Breast invasive adenocarcinoma(108;0.0136)|Epithelial(106;0.0564)|OV - Ovarian serous cystadenocarcinoma(136;0.0717)|all cancers(137;0.0743)		TGAAGACAACGTTCGTTCTGT	0.348000													13	29					1.15088e-07	1.20895e-07	1	1	0
HERC1	8925	broad.mit.edu	37	15	63986511	63986511	+	Splice_Site	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr15:63986511C>G	ENST00000443617.2	-	29	5567	c.5480G>C	c.(5479-5481)gGg>gCg	p.G1827A	RP11-317G6.1_ENST00000559303.2_RNA	NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	1827					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						CCATACTTACCCAGTAGTGAT	0.453000													7	8					0	0	1	0	0
WDR75	84128	broad.mit.edu	37	2	190334822	190334822	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr2:190334822G>A	ENST00000314761.4	+	17	1900	c.1840G>A	c.(1840-1842)Gag>Aag	p.E614K		NM_032168.1	NP_115544.1	Q8IWA0	WDR75_HUMAN	WD repeat domain 75	614						nucleolus				breast(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.00105)|Epithelial(96;0.0129)|all cancers(119;0.0456)			TAAACCTAGTGAGCCAAGGCC	0.418000													47	89					0	0	1	0	0
PLA2G4C	8605	broad.mit.edu	37	19	48551600	48551600	+	Nonstop_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:48551600C>G	ENST00000599111.1	-	17	1957	c.1656G>C	c.(1654-1656)taG>taC	p.*552Y	PLA2G4C_ENST00000413144.2_Nonstop_Mutation_p.*542Y|PLA2G4C_ENST00000354276.3_3'UTR|PLA2G4C_ENST00000599921.1_Nonstop_Mutation_p.*542Y	NM_001159322.1|NM_003706.2	NP_001152794.1|NP_003697.2	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC (cytosolic, calcium-independent)	0					arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(12)|lung(13)|ovary(2)|prostate(1)|skin(3)	38		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)		TGAGGCTCATCTATGCCAAGC	0.547000													22	22					0	0	1	0	0
PEX6	5190	broad.mit.edu	37	6	42935166	42935166	+	Silent	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:42935166G>C	ENST00000304611.8	-	8	1893	c.1824C>G	c.(1822-1824)ctC>ctG	p.L608L	PEX6_ENST00000244546.4_Silent_p.L608L	NM_000287.3	NP_000278.3	Q13608	PEX6_HUMAN	peroxisomal biogenesis factor 6	608					protein import into peroxisome matrix, translocation|protein stabilization	cytosol|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(3)	15			all cancers(41;0.00235)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0562)			GGTGGGCAGTGAGGGCCCGCA	0.637000													4	13					0	0	1	0	0
RPTOR	57521	broad.mit.edu	37	17	78923268	78923268	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr17:78923268G>A	ENST00000306801.3	+	28	3653	c.3291G>A	c.(3289-3291)aaG>aaA	p.K1097K	RPTOR_ENST00000544334.2_Silent_p.K939K|RPTOR_ENST00000575542.1_3'UTR	NM_020761.2	NP_065812.1	Q8N122	RPTOR_HUMAN	regulatory associated protein of MTOR, complex 1	1097					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(3)	44						GGGTCTGGAAGAATTTTGCTG	0.612000													18	167					0	0	1	0	0
PAGE4	9506	broad.mit.edu	37	X	49597171	49597171	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chrX:49597171G>C	ENST00000218068.6	+	4	289	c.210G>C	c.(208-210)aaG>aaC	p.K70N	PAGE4_ENST00000376141.1_Missense_Mutation_p.K70N	NM_007003.2	NP_008934.1	O60829	GAGC1_HUMAN	P antigen family, member 4 (prostate associated)	70												Ovarian(276;0.236)					ATCTGGAAAAGACTCGGAGTG	0.358000													3	35					0	0	1	0	0
PM20D1	148811	broad.mit.edu	37	1	205797765	205797765	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:205797765G>A	ENST00000367136.4	-	13	1536	c.1492C>T	c.(1492-1494)Cac>Tac	p.H498Y	PM20D1_ENST00000460624.1_5'UTR	NM_152491.4	NP_689704.4	Q6GTS8	P20D1_HUMAN	peptidase M20 domain containing 1	498						extracellular region	metal ion binding|peptidase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)	28	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			TTGTGCAGGTGAGAAACTGGC	0.502000													15	48					0	0	1	0	0
SPNS1	83985	broad.mit.edu	37	16	28989291	28989291	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr16:28989291C>T	ENST00000311008.11	+	3	747	c.370C>T	c.(370-372)Cgg>Tgg	p.R124W	RP11-264B17.4_ENST00000567209.1_RNA|SPNS1_ENST00000323081.8_Missense_Mutation_p.R51W|SPNS1_ENST00000561868.1_Intron|RP11-264B17.3_ENST00000569969.1_RNA|SPNS1_ENST00000565975.1_Missense_Mutation_p.R169W|SPNS1_ENST00000334536.8_Missense_Mutation_p.R124W|SPNS1_ENST00000352260.7_Missense_Mutation_p.R102W	NM_032038.2	NP_114427.1	Q9H2V7	SPNS1_HUMAN	spinster homolog 1 (Drosophila)	124					lipid transport|transmembrane transport	integral to membrane|mitochondrial inner membrane	protein binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)|urinary_tract(1)	21						CAGGTACAATCGGAAGTATCT	0.567000											OREG0023711	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	55	107					0	0	1	0	0
ZNF671	79891	broad.mit.edu	37	19	58233714	58233714	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:58233714C>T	ENST00000317398.6	-	3	453	c.358G>A	c.(358-360)Gaa>Aaa	p.E120K	AC003006.7_ENST00000594684.1_Intron|AC003006.7_ENST00000599221.1_Intron|ZNF671_ENST00000594803.1_5'UTR|ZNF671_ENST00000596939.1_3'UTR|ZNF671_ENST00000335820.3_Missense_Mutation_p.E22K	NM_024833.2	NP_079109.2	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	120	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(6)|liver(1)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GCCTCTCTTTCTGTGGCTGAA	0.502000													55	118					0	0	1	0	0
FAR2	55711	broad.mit.edu	37	12	29485662	29485662	+	Splice_Site	SNP	T	T	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:29485662T>G	ENST00000536681.3	+	11	1631		c.e11+2		FAR2_ENST00000182377.4_Splice_Site|FAR2_ENST00000547116.1_Splice_Site	NM_001271783.1|NM_001271784.1	NP_001258712.1|NP_001258713.1	Q96K12	FACR2_HUMAN	fatty acyl CoA reductase 2						ether lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor			central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(15)|prostate(1)|stomach(1)	29						CTTAAAAAGGTAAGTATAAtc	0.348000													11	17					0	0	1	0	0
HMGCS2	3158	broad.mit.edu	37	1	120301788	120301788	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:120301788C>T	ENST00000369406.3	-	4	852	c.803G>A	c.(802-804)cGa>cAa	p.R268Q	HMGCS2_ENST00000476640.1_Intron|HMGCS2_ENST00000544913.2_Missense_Mutation_p.R226Q	NM_005518.3	NP_005509.1	P54868	HMCS2_HUMAN	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	268					acetoacetic acid biosynthetic process|cholesterol biosynthetic process|isoprenoid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA synthase activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	28	all_cancers(5;6.38e-10)|all_epithelial(5;1.1e-10)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;1.29e-06)|Lung NSC(69;9.35e-06)|all_epithelial(167;0.00124)		Lung(183;0.0112)|LUSC - Lung squamous cell carcinoma(189;0.0595)		TGTGTAACATCGATCCAAGGC	0.458000													20	47					0	0	1	0	0
ASCC2	84164	broad.mit.edu	37	22	30221764	30221764	+	Silent	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr22:30221764G>C	ENST00000397771.2	-	4	264	c.87C>G	c.(85-87)ccC>ccG	p.P29P	ASCC2_ENST00000307790.3_Silent_p.P29P|ASCC2_ENST00000542393.1_Intron			Q9H1I8	ASCC2_HUMAN	activating signal cointegrator 1 complex subunit 2	29					regulation of transcription, DNA-dependent|transcription, DNA-dependent					endometrium(3)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(5;0.000103)|Epithelial(10;0.0169)|all cancers(5;0.0259)			CCTTCTGCTCGGGGTGCTACG	0.537000													9	147					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29625947	29625947	+	Missense_Mutation	SNP	T	T	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr20:29625947T>C	ENST00000278882.3	+	5	571	c.191T>C	c.(190-192)aTt>aCt	p.I64T	FRG1B_ENST00000439954.2_Missense_Mutation_p.I69T|FRG1B_ENST00000358464.4_Missense_Mutation_p.I64T														p.I64T(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TCAGATGCAATTGGACCAAGA	0.343000													4	110					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189867023	189867023	+	Splice_Site	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr2:189867023G>A	ENST00000304636.3	+	35	2561		c.e35-1		COL3A1_ENST00000317840.5_Splice_Site	NM_000090.3	NP_000081	P02461	CO3A1_HUMAN	collagen, type III, alpha 1						axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TTTCTCTTCAGGGTGAGAGAG	0.443000													15	15					0	0	1	0	0
HSPA1B	3304	broad.mit.edu	37	6	31797453	31797453	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:31797453G>C	ENST00000375650.3	+	1	1942	c.1726G>C	c.(1726-1728)Gag>Cag	p.E576Q	HSPA1B_ENST00000545241.1_Missense_Mutation_p.E485Q	NM_005346.4	NP_005337.2	P08107	HSP71_HUMAN	heat shock 70kDa protein 1B	576					anti-apoptosis|mRNA catabolic process|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of inclusion body assembly|protein refolding|response to unfolded protein	cytosol|endoplasmic reticulum|inclusion body|mitochondrion|nuclear speck|perinuclear region of cytoplasm|ribonucleoprotein complex	ATP binding|protein binding involved in protein folding|protein N-terminus binding|receptor activity|ubiquitin protein ligase binding|unfolded protein binding			breast(1)|large_intestine(1)|prostate(1)	3						CAAGTGTCAAGAGGTCATCTC	0.572000													11	35					0	0	1	0	0
GALNTL6	442117	broad.mit.edu	37	4	173961165	173961165	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr4:173961165G>A	ENST00000506823.1	+	13	2377	c.1720G>A	c.(1720-1722)Gac>Aac	p.D574N	GALNTL6_ENST00000508122.1_Missense_Mutation_p.D557N	NM_001034845.2	NP_001030017.2	Q49A17	GLTL6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	574	Ricin B-type lectin.					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(2)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	45						GGCCAGATGTGACCCTCTCTC	0.428000													10	35					0	0	1	0	0
STMN2	11075	broad.mit.edu	37	8	80553752	80553752	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr8:80553752G>A	ENST00000220876.7	+	3	637	c.255G>A	c.(253-255)caG>caA	p.Q85Q	STMN2_ENST00000518491.1_Silent_p.Q74Q|STMN2_ENST00000518111.1_Silent_p.Q85Q	NM_001199214.1|NM_007029.3	NP_001186143.1|NP_008960.2	Q93045	STMN2_HUMAN	stathmin-like 2	85	Regulatory/phosphorylation domain (Potential).				intracellular signal transduction|negative regulation of microtubule depolymerization|negative regulation of microtubule polymerization|negative regulation of neuron projection development|neuron differentiation|positive regulation of microtubule depolymerization|positive regulation of neuron projection development	axon|growth cone|membrane|membrane fraction|perinuclear region of cytoplasm|soluble fraction	protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	11	all_lung(9;8.34e-05)		Epithelial(68;0.0229)|all cancers(69;0.0874)			AGGAGATCCAGAAGAAACTGG	0.502000													20	63					0	0	1	0	0
PCDHB10	56126	broad.mit.edu	37	5	140573365	140573365	+	Missense_Mutation	SNP	A	A	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr5:140573365A>G	ENST00000239446.4	+	1	1424	c.1240A>G	c.(1240-1242)Aga>Gga	p.R414G		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		414	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAGAGAGATCAGAGCCGAGTA	0.473000													9	44					0	0	1	0	0
CCHCR1	54535	broad.mit.edu	37	6	31116182	31116182	+	Splice_Site	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:31116182C>T	ENST00000396268.3	-	10	1768	c.1580G>A	c.(1579-1581)aGc>aAc	p.S527N	CCHCR1_ENST00000451521.2_Splice_Site_p.S491N|CCHCR1_ENST00000376266.5_Splice_Site_p.S438N|CCHCR1_ENST00000396263.2_Splice_Site_p.S438N	NM_001105563.1|NM_001105564.1	NP_001099033.1|NP_001099034.1	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1	438					cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(13)|skin(1)	23						TCCCTGATACCTGCTGACAGC	0.612000													13	89					0	0	1	0	0
OR51B4	79339	broad.mit.edu	37	11	5323047	5323047	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:5323047G>C	ENST00000380224.1	-	1	179	c.130C>G	c.(130-132)Ctt>Gtt	p.L44V	HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron	NM_033179.2	NP_149419.2	Q9Y5P0	O51B4_HUMAN	olfactory receptor, family 51, subfamily B, member 4	44					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	20		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATGAGGACAAGAAGAGTGCCA	0.493000													14	48					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227886797	227886797	+	Missense_Mutation	SNP	C	C	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr2:227886797C>A	ENST00000396625.3	-	44	4390	c.4183G>T	c.(4183-4185)Ggg>Tgg	p.G1395W	COL4A4_ENST00000329662.7_Missense_Mutation_p.G1392W	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1395	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CCAGGGAGCCCCATGGCTCCT	0.522000													4	203					0.150653	0.151314	1	1	0
MRPL43	84545	broad.mit.edu	37	10	102746590	102746590	+	Missense_Mutation	SNP	C	C	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr10:102746590C>A	ENST00000318325.2	-	3	434	c.381G>T	c.(379-381)caG>caT	p.Q127H	MRPL43_ENST00000299179.5_Missense_Mutation_p.Q127H|MRPL43_ENST00000477279.1_3'UTR|MRPL43_ENST00000370241.3_Missense_Mutation_p.Q127H|MRPL43_ENST00000370234.4_Missense_Mutation_p.Q127H|MRPL43_ENST00000493646.1_5'UTR|MRPL43_ENST00000370242.4_Missense_Mutation_p.Q127H|MRPL43_ENST00000318364.8_Missense_Mutation_p.Q127H|MRPL43_ENST00000342071.1_Missense_Mutation_p.Q127H|MRPL43_ENST00000370236.1_Missense_Mutation_p.Q127H	NM_176792.2	NP_789762.1	Q8N983	RM43_HUMAN	mitochondrial ribosomal protein L43	127					translation	mitochondrial ribosome	protein binding|structural constituent of ribosome			endometrium(1)|skin(2)|upper_aerodigestive_tract(1)	4		Colorectal(252;0.234)		Epithelial(162;6.21e-09)|all cancers(201;3.14e-07)		GCCACTGGCCCTGGATGCTAG	0.642000													3	23					6.4e-05	6.58697e-05	1	1	0
SRGAP1	57522	broad.mit.edu	37	12	64437274	64437274	+	Silent	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:64437274G>C	ENST00000355086.3	+	6	1244	c.720G>C	c.(718-720)cgG>cgC	p.R240R	SRGAP1_ENST00000543397.1_Silent_p.R200R|SRGAP1_ENST00000357825.3_Silent_p.R240R|RP11-196H14.2_ENST00000535594.1_RNA	NM_020762.2	NP_065813.1	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	240					axon guidance	cytosol				breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(26)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	65			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		TTAAGGCACGGAACGAATATC	0.338000													7	89					0	0	1	0	0
HIST1H2BO	8348	broad.mit.edu	37	6	27861503	27861503	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:27861503C>T	ENST00000303806.4	+	1	301	c.263C>T	c.(262-264)tCg>tTg	p.S88L		NM_003527.4	NP_003518.2	P23527	H2B1O_HUMAN	histone cluster 1, H2bo	88					nucleosome assembly	nucleosome|nucleus	DNA binding										AACAAGCGCTCGACCATCACC	0.622000													44	65					0	0	1	0	0
NCOA1	8648	broad.mit.edu	37	2	24933960	24933960	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr2:24933960G>C	ENST00000405141.1	+	15	3290	c.2579G>C	c.(2578-2580)aGa>aCa	p.R860T	NCOA1_ENST00000348332.3_Missense_Mutation_p.R860T|NCOA1_ENST00000538539.1_Missense_Mutation_p.R860T|NCOA1_ENST00000395856.3_Missense_Mutation_p.R860T|NCOA1_ENST00000406961.1_Missense_Mutation_p.R860T|NCOA1_ENST00000407230.1_Missense_Mutation_p.R709T|NCOA1_ENST00000288599.5_Missense_Mutation_p.R860T			Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1	860	Interaction with CREBBP.								PAX3/NCOA1(8)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(26)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	53	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCACTGCCAGACCCACTTCC	0.468000			T	PAX3	alveolar rhadomyosarcoma								3	17					0	0	1	0	0
GDPD4	220032	broad.mit.edu	37	11	76990424	76990424	+	Missense_Mutation	SNP	C	C	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:76990424C>A	ENST00000315938.4	-	3	324	c.74G>T	c.(73-75)gGa>gTa	p.G25V	GDPD4_ENST00000527489.1_Intron|GDPD4_ENST00000376217.2_Missense_Mutation_p.G25V	NM_182833.1	NP_878253.1	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain containing 4	25					glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	20						AAACCAGTATCCTGTTCCTAG	0.388000													10	38					0.000978159	0.000995548	1	1	0
ITPRIP	85450	broad.mit.edu	37	10	106075690	106075690	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr10:106075690C>G	ENST00000278071.2	-	3	572	c.120G>C	c.(118-120)aaG>aaC	p.K40N	ITPRIP_ENST00000337478.1_Missense_Mutation_p.K40N|ITPRIP_ENST00000358187.2_Missense_Mutation_p.K40N	NM_033397.2	NP_203755.1	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein	40						plasma membrane				breast(1)|endometrium(3)|large_intestine(5)|liver(1)|lung(9)|upper_aerodigestive_tract(1)	20						GCGCCTGCATCTTGCGGATGA	0.657000													13	44					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47398430	47398430	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:47398430C>T	ENST00000371905.1	-	11	1397	c.1367G>A	c.(1366-1368)tGa>tAa	p.*456*	CYP4A11_ENST00000371904.4_Intron|CYP4A11_ENST00000462347.1_Intron|CYP4A11_ENST00000310638.4_Intron			Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	0					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	CAGGACGTCTCACCTTGATCC	0.517000													61	135					0	0	1	0	0
MDGA2	161357	broad.mit.edu	37	14	47426651	47426651	+	Missense_Mutation	SNP	T	T	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr14:47426651T>A	ENST00000426342.1	-	9	1867	c.1121A>T	c.(1120-1122)aAt>aTt	p.N374I	MDGA2_ENST00000399232.2_Missense_Mutation_p.N603I|MDGA2_ENST00000357362.3_Missense_Mutation_p.N374I|MDGA2_ENST00000439988.3_Missense_Mutation_p.N672I	NM_182830.3	NP_878250.2	Q7Z553	MDGA2_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 2	603	Ig-like 4.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				breast(3)|endometrium(4)|kidney(2)|large_intestine(14)|lung(41)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(5)	76						ATAGTTTTCATTGGAAAGACT	0.423000													18	29					0	0	1	0	0
EHMT2	10919	broad.mit.edu	37	6	31860311	31860311	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:31860311G>A	ENST00000395728.3	-	6	907	c.908C>T	c.(907-909)tCa>tTa	p.S303L	EHMT2_ENST00000375530.4_Missense_Mutation_p.S246L|EHMT2_ENST00000375537.4_Missense_Mutation_p.S246L|EHMT2_ENST00000480912.1_5'UTR|EHMT2_ENST00000375528.4_Missense_Mutation_p.S303L			Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	246	Poly-Glu.				DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			central_nervous_system(1)|cervix(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	21						CACTTCTCCTGAACGCCGGGC	0.542000													11	40					0	0	1	0	0
IGSF22	283284	broad.mit.edu	37	11	18735838	18735838	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:18735838G>C	ENST00000513874.1	-	13	1923	c.1784C>G	c.(1783-1785)tCt>tGt	p.S595C	RP11-1081L13.4_ENST00000527285.1_RNA	NM_173588.3	NP_775859	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	595										NS(2)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(20)|ovary(4)|prostate(4)|skin(3)	56						GATGAATACAGAGGCTTCACT	0.577000													8	19					0	0	1	0	0
CDHR5	53841	broad.mit.edu	37	11	620128	620128	+	Missense_Mutation	SNP	G	G	A	rs144175464		TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:620128G>A	ENST00000358353.3	-	10	1239	c.917C>T	c.(916-918)tCg>tTg	p.S306L	CDHR5_ENST00000349570.7_Missense_Mutation_p.S306L|CDHR5_ENST00000397542.2_Missense_Mutation_p.S306L			Q9HBB8	CDHR5_HUMAN	cadherin-related family member 5	306	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	23						GAGGTTGCCCGAGTCTGGGTG	0.647000													3	12					0	0	1	0	0
DOCK6	57572	broad.mit.edu	37	19	11319642	11319642	+	Missense_Mutation	SNP	T	T	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:11319642T>C	ENST00000294618.7	-	38	4900	c.4889A>G	c.(4888-4890)tAc>tGc	p.Y1630C	DOCK6_ENST00000319867.7_Missense_Mutation_p.Y969C|CTC-510F12.2_ENST00000588634.1_RNA	NM_020812.3	NP_065863.2	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1630	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(8)|liver(2)|lung(9)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	39						CAGGGCGAGGTACTCAGCCAC	0.697000													6	13					0	0	1	0	0
TSC1	7248	broad.mit.edu	37	9	135786887	135786887	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr9:135786887G>A	ENST00000298552.3	-	10	1203	c.982C>T	c.(982-984)Cag>Tag	p.Q328*	TSC1_ENST00000545250.1_Nonsense_Mutation_p.Q277*|TSC1_ENST00000440111.2_Nonsense_Mutation_p.Q328*|TSC1_ENST00000403810.1_Nonsense_Mutation_p.Q328*	NM_000368.4|NM_001162426.1|NM_001162427.1	NP_000359.1|NP_001155898.1|NP_001155899.1	Q92574	TSC1_HUMAN	tuberous sclerosis 1	328					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.Q328*(1)|p.?(1)		NS(1)|bone(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(9)|lung(20)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	65				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		CTCAGAGTCTGAGGTAGCTGC	0.502000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				37	23					0	0	1	0	0
WDR64	128025	broad.mit.edu	37	1	241929556	241929556	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:241929556G>C	ENST00000366552.2	+	15	2161	c.1954G>C	c.(1954-1956)Gat>Cat	p.D652H	WDR64_ENST00000437684.2_Missense_Mutation_p.D652H	NM_144625.4	NP_653226.4	B1ANS9	WDR64_HUMAN	WD repeat domain 64	652										breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(17)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			GAACTGCATTGATTTACTACA	0.368000													6	68					0	0	1	0	0
SIRPD	128646	broad.mit.edu	37	20	1532496	1532496	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr20:1532496C>G	ENST00000381623.3	-	2	1451	c.262G>C	c.(262-264)Gag>Cag	p.E88Q	SIRPD_ENST00000381621.1_Missense_Mutation_p.E88Q			Q9H106	SIRPD_HUMAN	signal-regulatory protein delta	88	Ig-like V-type.					extracellular region				breast(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|skin(1)	15						TCTCCAATCTCTTTTACTCTG	0.453000													5	63					0	0	1	0	0
SLC35F3	148641	broad.mit.edu	37	1	234367198	234367198	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:234367198G>A	ENST00000366618.3	+	3	464	c.319G>A	c.(319-321)Gag>Aag	p.E107K	SLC35F3_ENST00000366617.3_Missense_Mutation_p.E38K	NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	38					transport	integral to membrane				breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			GGGCCCGGCGGAGGCCCAGGC	0.741000													7	23					0	0	1	0	0
TBKBP1	9755	broad.mit.edu	37	17	45786543	45786543	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr17:45786543G>A	ENST00000361722.3	+	8	2293	c.1444G>A	c.(1444-1446)Gaa>Aaa	p.E482K		NM_014726.2	NP_055541.1	A7MCY6	TBKB1_HUMAN	TBK1 binding protein 1	482					innate immune response					endometrium(5)|kidney(1)|lung(1)	7						GCTGCAGGCCGAAGCGGCCAC	0.766000													11	4					0	0	1	0	0
PCGF2	7703	broad.mit.edu	37	17	36894838	36894838	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr17:36894838C>T	ENST00000580830.1	-	9	1137	c.436G>A	c.(436-438)Gag>Aag	p.E146K	PCGF2_ENST00000579882.1_Missense_Mutation_p.R147Q|PCGF2_ENST00000360797.2_Missense_Mutation_p.E146K|PCGF2_ENST00000581345.1_Missense_Mutation_p.E146K|PCGF2_ENST00000585100.1_Missense_Mutation_p.R147Q|PCGF2_ENST00000578109.1_Missense_Mutation_p.R93Q			P35227	PCGF2_HUMAN	polycomb group ring finger 2	146					negative regulation of transcription from RNA polymerase II promoter	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	10	Breast(7;9.07e-22)					CCCTTCTTCTCGTCCCGGTCC	0.602000													42	45					0	0	1	0	0
SLC35F3	148641	broad.mit.edu	37	1	234458935	234458935	+	Silent	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:234458935G>C	ENST00000366618.3	+	8	1564	c.1419G>C	c.(1417-1419)ctG>ctC	p.L473L	SLC35F3_ENST00000366617.3_Silent_p.L404L	NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	404					transport	integral to membrane				breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			CTGCCGACCTGAGCTCAGGAC	0.582000											OREG0014330	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	29					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94120130	94120130	+	Missense_Mutation	SNP	C	C	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr14:94120130C>A	ENST00000553484.1	+	38	6463	c.6309C>A	c.(6307-6309)ttC>ttA	p.F2103L	UNC79_ENST00000393151.2_Missense_Mutation_p.F2081L|UNC79_ENST00000555664.1_Missense_Mutation_p.F2042L|UNC79_ENST00000256339.4_Missense_Mutation_p.F1904L			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2081						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						CCAAGCAGTTCCTGCGCTGCA	0.567000													31	115					3.11337e-16	3.37098e-16	1	1	0
CNOT4	4850	broad.mit.edu	37	7	135099985	135099985	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr7:135099985C>T	ENST00000428680.2	-	4	678	c.399G>A	c.(397-399)ggG>ggA	p.G133G	CNOT4_ENST00000541284.1_Silent_p.G133G|CNOT4_ENST00000423368.2_Silent_p.G133G|CNOT4_ENST00000315544.5_Silent_p.G133G|CNOT4_ENST00000451834.1_Silent_p.G133G|CNOT4_ENST00000414802.1_Silent_p.G133G|CNOT4_ENST00000361528.4_Silent_p.G133G|CNOT4_ENST00000356162.4_Silent_p.G133G	NM_001008225.2	NP_001008226.1	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	133	RRM.				nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)	22						TACCAAACTTCCCAAAATATT	0.318000													41	81					0	0	1	0	0
ZNF623	9831	broad.mit.edu	37	8	144733319	144733319	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr8:144733319C>T	ENST00000501748.2	+	1	1366	c.1277C>T	c.(1276-1278)tCt>tTt	p.S426F	ZNF623_ENST00000458270.2_Missense_Mutation_p.S386F|ZNF623_ENST00000526926.1_Missense_Mutation_p.S386F	NM_014789.3	NP_055604	O75123	ZN623_HUMAN	zinc finger protein 623	426					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(6)|lung(11)|prostate(1)|stomach(1)|urinary_tract(3)	27	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			AAGATCCACTCTGGGGACAGG	0.488000													47	70					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51872205	51872205	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr20:51872205C>T	ENST00000371497.5	+	2	3095	c.2208C>T	c.(2206-2208)gtC>gtT	p.V736V	TSHZ2_ENST00000603338.2_Silent_p.V733V|TSHZ2_ENST00000329613.6_Silent_p.V733V	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	736					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			ATCTCAATGTCATGGACAAGC	0.542000													9	43					0	0	1	0	0
IFT172	26160	broad.mit.edu	37	2	27672878	27672878	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr2:27672878C>G	ENST00000260570.3	-	36	4140	c.4037G>C	c.(4036-4038)gGa>gCa	p.G1346A		NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	1346					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					ACTGTGCTTTCCAATTCCAAT	0.488000													10	35					0	0	1	0	0
VWA8	23078	broad.mit.edu	37	13	42273230	42273230	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr13:42273230G>C	ENST00000379310.3	-	29	3609	c.3541C>G	c.(3541-3543)Caa>Gaa	p.Q1181E		NM_015058.1	NP_055873.1			von Willebrand factor A domain containing 8																		AGAACCACTTGACCTTTGAGA	0.453000													26	57					0	0	1	0	0
GNL2	29889	broad.mit.edu	37	1	38034699	38034699	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:38034699G>A	ENST00000373062.3	-	13	1719	c.1621C>T	c.(1621-1623)Cag>Tag	p.Q541*	GNL2_ENST00000462812.1_5'UTR	NM_013285.2	NP_037417.1	Q13823	NOG2_HUMAN	guanine nucleotide binding protein-like 2 (nucleolar)	541					ribosome biogenesis	nucleolus	GTP binding|GTPase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	30		Myeloproliferative disorder(586;0.0393)				CCAGAAAACTGAGGCACCACG	0.478000													35	37					0	0	1	0	0
SESN3	143686	broad.mit.edu	37	11	94918464	94918464	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:94918464C>T	ENST00000536441.1	-	5	1054	c.718G>A	c.(718-720)Gac>Aac	p.D240N	RP11-712B9.2_ENST00000534864.1_RNA|SESN3_ENST00000278499.2_Missense_Mutation_p.D101N|SESN3_ENST00000393234.1_Missense_Mutation_p.D240N|RP11-712B9.2_ENST00000534891.1_RNA|SESN3_ENST00000416495.2_Missense_Mutation_p.D240N	NM_001271594.1|NM_144665.2	NP_001258523.1|NP_653266.2	P58005	SESN3_HUMAN	sestrin 3	240					cell cycle arrest	nucleus				endometrium(5)|large_intestine(6)|lung(3)|skin(1)|stomach(1)	16		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.234)		ATGTTGTTGTCATTAGCAAGA	0.343000													70	86					0	0	1	0	0
OR2B11	127623	broad.mit.edu	37	1	247614387	247614387	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:247614387C>G	ENST00000318749.6	-	1	921	c.898G>C	c.(898-900)Gat>Cat	p.D300H		NM_001004492.1	NP_001004492.1	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B, member 11	300			D -> G (in dbSNP:rs12070953).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(13)|large_intestine(7)|lung(31)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	60	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CCCTTCATATCTTTATTTCTC	0.473000													21	255					0	0	1	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18955509	18955509	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:18955509C>T	ENST00000302797.3	-	1	1047	c.823G>A	c.(823-825)Gtg>Atg	p.V275M		NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	275					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						AAGGAGCCCACGAAGAAGTAA	0.507000													15	50					0	0	1	0	0
CEP152	22995	broad.mit.edu	37	15	49083544	49083544	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr15:49083544G>A	ENST00000380950.2	-	8	1049	c.862C>T	c.(862-864)Cga>Tga	p.R288*	CEP152_ENST00000325747.5_Nonsense_Mutation_p.R195*|CEP152_ENST00000399334.3_Nonsense_Mutation_p.R288*	NM_001194998.1|NM_014985.3	NP_001181927.1|NP_055800.2	O94986	CE152_HUMAN	centrosomal protein 152kDa	288					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(16)|lung(30)|ovary(1)|prostate(2)|skin(2)	63		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		TGTGATTCTCGAAGGCTGAGA	0.368000													9	64					0	0	1	0	0
GCNT3	9245	broad.mit.edu	37	15	59910783	59910783	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr15:59910783G>A	ENST00000396065.1	+	3	794	c.346G>A	c.(346-348)Gaa>Aaa	p.E116K	GCNT3_ENST00000560585.1_Missense_Mutation_p.E116K	NM_004751.2	NP_004742.1	O95395	GCNT3_HUMAN	glucosaminyl (N-acetyl) transferase 3, mucin type	116					protein O-linked glycosylation	Golgi membrane|integral to membrane|membrane fraction	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CTTCAAGGCTGAAAGGAAGTT	0.458000													20	42					0	0	1	0	0
ARHGEF19	128272	broad.mit.edu	37	1	16535331	16535331	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:16535331G>A	ENST00000270747.3	-	2	355	c.219C>T	c.(217-219)ctC>ctT	p.L73L		NM_153213.3	NP_694945.2	Q8IW93	ARHGJ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 19	73					regulation of actin cytoskeleton organization	intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(1)|lung(3)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|Colorectal(212;3.48e-07)|COAD - Colon adenocarcinoma(227;2.19e-05)|BRCA - Breast invasive adenocarcinoma(304;9.46e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0117)|READ - Rectum adenocarcinoma(331;0.0649)		GCAACCCTTGGAGAGGGGCAG	0.657000													6	18					0	0	1	0	0
NMD3	51068	broad.mit.edu	37	3	160942797	160942797	+	Missense_Mutation	SNP	A	A	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:160942797A>T	ENST00000460469.1	+	2	579	c.124A>T	c.(124-126)Atc>Ttc	p.I42F	NMD3_ENST00000351193.2_Missense_Mutation_p.I42F|NMD3_ENST00000472947.1_Missense_Mutation_p.I42F|NMD3_ENST00000478160.1_3'UTR			Q96D46	NMD3_HUMAN	NMD3 ribosome export adaptor	42					protein transport	cytoplasm|nucleolus|nucleoplasm				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(10)|ovary(1)|skin(1)|urinary_tract(2)	25			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)			TAAAGTGGACATCAGCCAAGG	0.388000													9	131					0	0	1	0	0
C1orf106	55765	broad.mit.edu	37	1	200880624	200880624	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:200880624G>A	ENST00000367342.4	+	9	1458	c.1258G>A	c.(1258-1260)Gcc>Acc	p.A420T	C1orf106_ENST00000413687.2_Missense_Mutation_p.A335T	NM_018265.3	NP_060735.3	Q3KP66	CA106_HUMAN	chromosome 1 open reading frame 106	420										endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(2)	21						AGGTCGCAGCGCCTTTCCCCG	0.667000													14	218					0	0	1	0	0
HSD17B14	51171	broad.mit.edu	37	19	49318311	49318311	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:49318311G>A	ENST00000263278.4	-	6	723	c.457C>T	c.(457-459)Ccc>Tcc	p.P153S	HSD17B14_ENST00000599157.1_Missense_Mutation_p.P129S	NM_016246.2	NP_057330.2	Q9BPX1	DHB14_HUMAN	hydroxysteroid (17-beta) dehydrogenase 14	153					steroid catabolic process	centrosome|cytosol	estradiol 17-beta-dehydrogenase activity|protein binding|testosterone 17-beta-dehydrogenase (NADP+) activity			large_intestine(3)|lung(1)|skin(1)	5		all_epithelial(76;7e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000341)|all cancers(93;0.000764)|GBM - Glioblastoma multiforme(486;0.0233)|Epithelial(262;0.0346)		GCCACATAGGGAACTGCCTGG	0.597000													15	26					0	0	1	0	0
HIF1A	3091	broad.mit.edu	37	14	62187267	62187267	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr14:62187267G>C	ENST00000394997.1	+	2	471	c.206G>C	c.(205-207)cGt>cCt	p.R69P	HIF1A_ENST00000557206.1_3'UTR|HIF1A_ENST00000539097.1_Missense_Mutation_p.R92P|HIF1A-AS2_ENST00000554254.1_lincRNA|HIF1A_ENST00000557538.1_Missense_Mutation_p.R9P|HIF1A_ENST00000323441.6_Missense_Mutation_p.R68P|HIF1A_ENST00000337138.4_Missense_Mutation_p.R68P			Q16665	HIF1A_HUMAN	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	68	Helix-loop-helix motif.|Interaction with TSGA10 (By similarity).				cellular response to hypoxia|collagen metabolic process|connective tissue replacement involved in inflammatory response wound healing|elastin metabolic process|epithelial to mesenchymal transition|oxygen homeostasis|positive regulation of chemokine production|positive regulation of epithelial cell migration|positive regulation of hormone biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of transforming growth factor-beta2 production	cytoplasm|nucleolus|transcription factor complex	histone acetyltransferase binding|Hsp90 protein binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			breast(2)|endometrium(8)|kidney(6)|large_intestine(3)|lung(4)	23				OV - Ovarian serous cystadenocarcinoma(108;1.62e-09)|BRCA - Breast invasive adenocarcinoma(234;0.189)		AGCTATTTGCGTGTGAGGAAA	0.378000													11	74					0	0	1	0	0
CPEB3	22849	broad.mit.edu	37	10	93870928	93870928	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr10:93870928C>A	ENST00000412050.4	-	7	1523	c.1435G>T	c.(1435-1437)Gag>Tag	p.E479*	CPEB3_ENST00000265997.4_Nonsense_Mutation_p.E493*	NM_001178137.1	NP_001171608.1	Q8NE35	CPEB3_HUMAN	cytoplasmic polyadenylation element binding protein 3	493	RRM 1.						nucleotide binding|RNA binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(5)|skin(2)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.0869)				GAGCTTTCCTCTTGGAACAGC	0.433000													34	115					4.32679e-17	4.6959e-17	1	1	0
PRPF31	26121	broad.mit.edu	37	19	54627966	54627966	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:54627966C>T	ENST00000321030.4	+	8	1135	c.786C>T	c.(784-786)ttC>ttT	p.F262F	PRPF31_ENST00000419967.1_Silent_p.F262F|PRPF31_ENST00000498612.1_3'UTR|PRPF31_ENST00000391755.1_Silent_p.F262F|AC012314.8_ENST00000452097.1_RNA	NM_015629.3	NP_056444.3	Q8WWY3	PRP31_HUMAN	pre-mRNA processing factor 31	262	Nop.				assembly of spliceosomal tri-snRNP	Cajal body|MLL1 complex|nuclear speck|U4 snRNP|U4/U6 x U5 tri-snRNP complex|U4atac snRNP	RNA binding|snRNP binding			breast(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(2)|urinary_tract(3)	12	all_cancers(19;0.00681)|all_epithelial(19;0.00362)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TGTCGGGCTTCTCGTCTACCT	0.667000													4	76					0	0	1	0	0
EFCAB3	146779	broad.mit.edu	37	17	60493412	60493412	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr17:60493412C>T	ENST00000450662.2	+	12	1266	c.1195C>T	c.(1195-1197)Cga>Tga	p.R399*	EFCAB3_ENST00000305286.3_Nonsense_Mutation_p.R347*	NM_001144933.1	NP_001138405.1	Q8N7B9	EFCB3_HUMAN	EF-hand calcium binding domain 3	347							calcium ion binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|skin(3)	17			BRCA - Breast invasive adenocarcinoma(2;2.27e-11)			CCTTGAACACCGAAAAGAGAT	0.398000													41	31					0	0	1	0	0
ZNF221	7638	broad.mit.edu	37	19	44470087	44470087	+	Missense_Mutation	SNP	C	C	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:44470087C>A	ENST00000251269.5	+	6	761	c.433C>A	c.(433-435)Cag>Aag	p.Q145K	ZNF221_ENST00000587682.1_Missense_Mutation_p.Q145K|ZNF221_ENST00000592350.1_Missense_Mutation_p.Q145K	NM_013359.2	NP_037491	Q9UK13	ZN221_HUMAN	zinc finger protein 221	145					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(11)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	30		Prostate(69;0.0352)				GAACAGCTCTCAGTTCTTCAA	0.443000													10	92					1.58986e-06	1.6549e-06	1	1	0
PCDHGB7	56099	broad.mit.edu	37	5	140799085	140799085	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr5:140799085C>T	ENST00000398594.2	+	1	1659	c.1659C>T	c.(1657-1659)ggC>ggT	p.G553G	PCDHGA4_ENST00000571252.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018927.3	NP_061750.1														central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(13)|lung(15)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(3)	56			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTTGGTGGGCGACCGTAACG	0.716000													11	29					0	0	1	0	0
NANOGP1	404635	broad.mit.edu	37	12	8051572	8051572	+	RNA	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:8051572C>T	ENST00000607111.1	+	0	792																				kidney(1)|lung(4)|prostate(1)	6						CTCCTCCCATCCCTCATAGGA	0.463000													9	47					0	0	1	0	0
BRPF1	7862	broad.mit.edu	37	3	9783111	9783111	+	Silent	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:9783111C>G	ENST00000383829.2	+	5	2246	c.1842C>G	c.(1840-1842)ctC>ctG	p.L614L	BRPF1_ENST00000457855.1_Silent_p.L614L|BRPF1_ENST00000424362.1_Silent_p.L614L|BRPF1_ENST00000302054.3_Silent_p.L614L|BRPF1_ENST00000433861.2_Silent_p.L614L	NM_001003694.1	NP_001003694.1	P55201	BRPF1_HUMAN	bromodomain and PHD finger containing, 1	614	Interaction with MEAF6 and ING5.|Required for RUNX1 and RUNX2 transcriptional activation.				histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	49	Medulloblastoma(99;0.227)					GGGAAAAACTCAAAAGGGAGA	0.537000													4	200					0	0	1	0	0
TBC1D12	23232	broad.mit.edu	37	10	96162370	96162370	+	Translation_Start_Site	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr10:96162370G>A	ENST00000225235.4	+	0	110					NM_015188.1	NP_056003.1	O60347	TBC12_HUMAN	TBC1 domain family, member 12							intracellular	Rab GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	20		Colorectal(252;0.0429)				CCCACCCCCAGATGGTGGGTC	0.697000													4	18					0	0	1	0	0
FRMD8	83786	broad.mit.edu	37	11	65156861	65156861	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:65156861G>A	ENST00000317568.5	+	3	278	c.115G>A	c.(115-117)Gac>Aac	p.D39N	FRMD8_ENST00000355991.5_Intron|FRMD8_ENST00000416776.2_Missense_Mutation_p.D39N	NM_031904.3	NP_114110.1	Q9BZ67	FRMD8_HUMAN	FERM domain containing 8	39	FERM.					cytoskeleton	binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|urinary_tract(1)	17						CCTAGCGGATGACACGGTGGT	0.662000													21	63					0	0	1	0	0
TRIM16	10626	broad.mit.edu	37	17	15535915	15535915	+	Missense_Mutation	SNP	G	G	A	rs145384017	byFrequency	TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr17:15535915G>A	ENST00000455584.2	-	4	966	c.923C>T	c.(922-924)tCg>tTg	p.S308L	TRIM16_ENST00000579219.1_Intron|TRIM16_ENST00000578237.1_Missense_Mutation_p.S308L|TRIM16_ENST00000577886.1_Missense_Mutation_p.S92L|TRIM16_ENST00000416464.2_Missense_Mutation_p.S178L|TRIM16_ENST00000336708.7_Missense_Mutation_p.S308L														p.S308*(1)									GCGGATGCCCGAGAGTTTATC	0.448000													4	56					0	0	1	0	0
SPDYC	387778	broad.mit.edu	37	11	64940365	64940365	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:64940365G>A	ENST00000377185.2	+	6	809	c.727G>A	c.(727-729)Gaa>Aaa	p.E243K		NM_001008778.1	NP_001008778.1	Q5MJ68	SPDYC_HUMAN	speedy/RINGO cell cycle regulator family member C	243					cell cycle	nucleus	protein kinase binding			breast(1)|endometrium(3)|large_intestine(2)|lung(9)|prostate(1)	16						TCTGACCTCTGAATGTCATCG	0.572000													40	47					0	0	1	0	0
TBKBP1	9755	broad.mit.edu	37	17	45786580	45786580	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr17:45786580G>A	ENST00000361722.3	+	8	2330	c.1481G>A	c.(1480-1482)aGc>aAc	p.S494N		NM_014726.2	NP_055541.1	A7MCY6	TBKB1_HUMAN	TBK1 binding protein 1	494					innate immune response					endometrium(5)|kidney(1)|lung(1)	7						GCCTACGGCAGCGAGCTCTAC	0.746000													8	5					0	0	1	0	0
ZNF12	7559	broad.mit.edu	37	7	6731481	6731481	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr7:6731481C>T	ENST00000405858.1	-	5	1633	c.1092G>A	c.(1090-1092)caG>caA	p.Q364Q	ZNF12_ENST00000342651.5_Silent_p.Q326Q|ZNF12_ENST00000404360.1_Silent_p.Q290Q|AC073343.13_ENST00000366167.2_RNA	NM_006956.2|NM_016265.3	NP_008887.2|NP_057349.2	P17014	ZNF12_HUMAN	zinc finger protein 12	364					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|endometrium(1)|large_intestine(1)|lung(7)|prostate(2)|upper_aerodigestive_tract(3)	16		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		GGTGTGTCTTCTGGCAAAAGG	0.428000													5	44					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155287443	155287443	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr4:155287443C>T	ENST00000357232.4	-	5	612	c.613G>A	c.(613-615)Gac>Aac	p.D205N	DCHS2_ENST00000339452.1_Missense_Mutation_p.D799N	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2		Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		ATCCCAGAGTCCTGGTCAGTG	0.473000													12	14					0	0	1	0	0
DTX4	23220	broad.mit.edu	37	11	58972187	58972187	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:58972187C>T	ENST00000227451.3	+	9	1769	c.1665C>T	c.(1663-1665)ctC>ctT	p.L555L	DTX4_ENST00000532982.1_Silent_p.L449L	NM_015177.1	NP_055992.1	Q9Y2E6	DTX4_HUMAN	deltex homolog 4 (Drosophila)	555					Notch signaling pathway	cytoplasm	zinc ion binding	p.L449L(1)|p.L555L(1)		central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	20		all_epithelial(135;0.125)				ATCGCCGCCTCATTTTTGCCA	0.522000													6	13					0	0	1	0	0
PSD	5662	broad.mit.edu	37	10	104170615	104170615	+	Splice_Site	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr10:104170615C>T	ENST00000020673.5	-	10	2617	c.2091G>A	c.(2089-2091)aaG>aaA	p.K697K	PSD_ENST00000406432.1_Splice_Site_p.K697K	NM_001270966.1|NM_002779.4	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	697	SEC7.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|endometrium(2)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		CGCCCCCCACCTTGAGCAGCT	0.657000													15	50					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	97848006	97848006	+	Silent	SNP	A	A	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:97848006A>C	ENST00000370192.3	-	15	2017	c.1917T>G	c.(1915-1917)gcT>gcG	p.A639A		NM_000110.3	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	639					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	ACATAATGCTAGCAATCACAA	0.274000													12	12					0	0	1	0	0
FRG1	2483	broad.mit.edu	37	4	190876261	190876261	+	Silent	SNP	A	A	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr4:190876261A>G	ENST00000226798.4	+	5	609	c.387A>G	c.(385-387)tcA>tcG	p.S129S	FRG1_ENST00000514482.1_3'UTR	NM_004477.2	NP_004468.1	Q14331	FRG1_HUMAN	FSHD region gene 1	129					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus				NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|lung(11)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|urinary_tract(1)	32		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		TTGGGCGTTCAGATGCAATTG	0.348000													4	136					0	0	1	0	0
ITGAE	3682	broad.mit.edu	37	17	3664784	3664784	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr17:3664784G>A	ENST00000263087.4	-	5	444	c.346C>T	c.(346-348)Cac>Tac	p.H116Y		NM_002208.4	NP_002199.3	P38570	ITAE_HUMAN	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	116					cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		CTGAGGCTGTGAGGCCGCCGG	0.602000													28	11					0	0	1	0	0
UTRN	7402	broad.mit.edu	37	6	144783808	144783808	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:144783808G>C	ENST00000367545.3	+	22	2872	c.2872G>C	c.(2872-2874)Gag>Cag	p.E958Q		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	958					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TGAAATCCTTGAGAATCAGAA	0.308000													14	30					0	0	1	0	0
ZNHIT3	9326	broad.mit.edu	37	17	34849778	34849778	+	Missense_Mutation	SNP	G	G	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr17:34849778G>T	ENST00000225410.4	+	4	279	c.214G>T	c.(214-216)Gac>Tac	p.D72Y	ZNHIT3_ENST00000490126.2_5'UTR|ZNHIT3_ENST00000592616.1_Missense_Mutation_p.D72Y|ZNHIT3_ENST00000590858.1_Intron|ZNHIT3_ENST00000588253.1_5'UTR	NM_004773.2	NP_004764.1	Q15649	ZNHI3_HUMAN	zinc finger, HIT-type containing 3	72					regulation of transcription, DNA-dependent	intracellular	metal ion binding|thyroid hormone receptor binding			lung(1)|pancreas(1)|prostate(1)	3		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0188)		AGATGATGATGACTCTATAGC	0.378000													17	121					1.33834e-09	1.42218e-09	1	1	0
PPP1CA	5499	broad.mit.edu	37	11	67167087	67167087	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:67167087G>C	ENST00000376745.4	-	4	616	c.468C>G	c.(466-468)ttC>ttG	p.F156L	PPP1CA_ENST00000358239.4_Missense_Mutation_p.F112L|PPP1CA_ENST00000532446.1_5'UTR|PPP1CA_ENST00000312989.7_Missense_Mutation_p.F167L	NM_001008709.1|NM_002708.3	NP_001008709.1|NP_002699.1	P62136	PP1A_HUMAN	protein phosphatase 1, catalytic subunit, alpha isozyme	156					cell cycle|cell division|glycogen metabolic process|protein dephosphorylation|triglyceride catabolic process	cytosol|MLL5-L complex|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|protein binding|protein phosphatase type 1 regulator activity|protein serine/threonine phosphatase activity			breast(1)|lung(2)|pancreas(1)|urinary_tract(3)	7			BRCA - Breast invasive adenocarcinoma(15;8.53e-07)			GCAGGCAGTTGAAGCAGTCAG	0.612000													9	36					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152280457	152280457	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:152280457G>C	ENST00000368799.1	-	3	6940	c.6905C>G	c.(6904-6906)tCa>tGa	p.S2302*	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2302	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGAGTGCCTGATTGTCTGGA	0.562000									Ichthyosis				132	314					0	0	1	0	0
TTYH2	94015	broad.mit.edu	37	17	72248459	72248459	+	Silent	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr17:72248459C>G	ENST00000441391.2	+	5	1452	c.240C>G	c.(238-240)ctC>ctG	p.L80L	TTYH2_ENST00000269346.4_Silent_p.L401L|TTYH2_ENST00000529107.1_Silent_p.L380L	NM_052869.1	NP_443101.1	Q9BSA4	TTYH2_HUMAN	tweety family member 2	401						chloride channel complex|plasma membrane	chloride channel activity|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(14)|ovary(3)|pancreas(1)|stomach(3)|upper_aerodigestive_tract(1)	36						TGGCCGCCCTCGCCTTCTCCA	0.612000													12	36					0	0	1	0	0
DUSP9	1852	broad.mit.edu	37	X	152914706	152914706	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chrX:152914706G>A	ENST00000342782.3	+	3	658	c.393G>A	c.(391-393)caG>caA	p.Q131Q	DUSP9_ENST00000370167.4_Silent_p.Q131Q			Q99956	DUS9_HUMAN	dual specificity phosphatase 9	131	Rhodanese.				inactivation of MAPK activity|JNK cascade	cytosol|endoplasmic reticulum|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)	16	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCAGATTCCAGGCCGAGTGCC	0.687000													19	11					0	0	1	0	0
DNM2	1785	broad.mit.edu	37	19	10912999	10912999	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:10912999C>T	ENST00000314646.5	+	12	1622	c.1458C>T	c.(1456-1458)atC>atT	p.I486I	DNM2_ENST00000389253.4_Silent_p.I486I|DNM2_ENST00000585892.1_Silent_p.I486I|DNM2_ENST00000355667.6_Silent_p.I486I|DNM2_ENST00000359692.6_Silent_p.I486I|DNM2_ENST00000408974.4_Silent_p.I486I			P50570	DYN2_HUMAN	dynamin 2	486					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding	p.I486M(2)		breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	42			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			AGTCCTACATCAACACGAACC	0.562000			"""F, N, Splice, Mis, O"""		ETP ALL								40	40					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40367905	40367905	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:40367905C>T	ENST00000221347.6	-	29	13062	c.13055G>A	c.(13054-13056)tGc>tAc	p.C4352Y		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4352	TIL 10.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GTTTTCTGGGCAGGTGATCTC	0.612000													20	64					0	0	1	0	0
ABCB5	340273	broad.mit.edu	37	7	20691144	20691144	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr7:20691144C>G	ENST00000404938.2	+	13	2086	c.1434C>G	c.(1432-1434)atC>atG	p.I478M	ABCB5_ENST00000406935.1_Missense_Mutation_p.I33M|ABCB5_ENST00000477094.1_3'UTR|ABCB5_ENST00000443026.2_Missense_Mutation_p.I33M|ABCB5_ENST00000258738.6_Missense_Mutation_p.I33M	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	33	ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						GGACCACCATCAGTAACAATA	0.428000													45	45					0	0	1	0	0
RCAN2	10231	broad.mit.edu	37	6	46216493	46216493	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:46216493G>A	ENST00000371374.1	-	3	557	c.366C>T	c.(364-366)ttC>ttT	p.F122F	RCAN2_ENST00000330430.6_Silent_p.F76F|RCAN2_ENST00000405162.1_Silent_p.F122F|RCAN2_ENST00000306764.7_Silent_p.F122F	NM_001251974.1	NP_001238903.1	Q14206	RCAN2_HUMAN	regulator of calcineurin 2	76					calcium-mediated signaling|central nervous system development		nucleotide binding|protein phosphatase 2B binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	8						TTTTCCCTCTGAATTGGGTTT	0.358000													10	43					0	0	1	0	0
ADAM30	11085	broad.mit.edu	37	1	120437633	120437633	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:120437633G>A	ENST00000369400.1	-	1	1485	c.1327C>T	c.(1327-1329)Ctt>Ttt	p.L443F		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	443	Disintegrin.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		TGACAGCAAAGTCCAATGCTA	0.468000													17	58					0	0	1	0	0
TEAD3	7005	broad.mit.edu	37	6	35443797	35443797	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:35443797C>T	ENST00000338863.7	-	10	1026	c.799G>A	c.(799-801)Gat>Aat	p.D267N	TEAD3_ENST00000402886.3_Missense_Mutation_p.D207N	NM_003214.3	NP_003205	Q99594	TEAD3_HUMAN	TEA domain family member 3	267	Transcriptional activation (Potential).				female pregnancy|hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	10						TGGCGCACATCTACTGCCTCC	0.557000													8	16					0	0	1	0	0
ADAM12	8038	broad.mit.edu	37	10	127798348	127798348	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr10:127798348C>T	ENST00000368679.4	-	7	983	c.674G>A	c.(673-675)cGa>cAa	p.R225Q	ADAM12_ENST00000368676.4_Missense_Mutation_p.R225Q	NM_003474.4	NP_003465.3	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12	225	Peptidase M12B.				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			biliary_tract(1)|breast(7)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		TCTTACCTCTCGGTTGTCTGC	0.378000													25	78					0	0	1	0	0
A2ML1	144568	broad.mit.edu	37	12	8975881	8975881	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:8975881C>T	ENST00000299698.7	+	2	346	c.166C>T	c.(166-168)Ctg>Ttg	p.L56L	A2ML1-AS1_ENST00000537288.1_RNA	NM_001282424.1|NM_144670.4	NP_001269353.1|NP_653271	B3KVV6	B3KVV6_HUMAN	alpha-2-macroglobulin-like 1	0						extracellular space	endopeptidase inhibitor activity			NS(2)|breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(2)|lung(36)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	80						CACGGTTACTCTGGAGACCAA	0.478000													34	44					0	0	1	0	0
CDH16	1014	broad.mit.edu	37	16	66942324	66942324	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr16:66942324C>T	ENST00000299752.4	-	18	2654	c.2461G>A	c.(2461-2463)Gac>Aac	p.D821N	CDH16_ENST00000565796.1_Missense_Mutation_p.D782N|CDH16_ENST00000570262.1_Missense_Mutation_p.D741N|CDH16_ENST00000394055.3_Missense_Mutation_p.D799N|CDH16_ENST00000568632.1_Missense_Mutation_p.D724N	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	821					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		GGCACGCTGTCTGCTGGTTGA	0.592000													21	59					0	0	1	0	0
PCF11	51585	broad.mit.edu	37	11	82892905	82892905	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:82892905G>C	ENST00000298281.4	+	13	4629	c.4177G>C	c.(4177-4179)Gaa>Caa	p.E1393Q	RP11-727A23.4_ENST00000528133.1_RNA	NM_015885.3	NP_056969.2	O94913	PCF11_HUMAN	PCF11 cleavage and polyadenylation factor subunit	1393					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				cervix(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(22)|ovary(1)|urinary_tract(1)	33						GGACTGGATAGAATTTGAGGA	0.348000													6	12					0	0	1	0	0
TDRD1	56165	broad.mit.edu	37	10	115964594	115964594	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr10:115964594C>T	ENST00000251864.2	+	10	1392	c.1239C>T	c.(1237-1239)gtC>gtT	p.V413V	TDRD1_ENST00000369280.1_Silent_p.V413V|TDRD1_ENST00000369282.1_Silent_p.V413V|TDRD1_ENST00000422662.1_Silent_p.V74V|TDRD1_ENST00000369281.2_Silent_p.V413V	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	413					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		TAAAGATTGTCGACATCTTGG	0.393000													25	51					0	0	1	0	0
COL16A1	1307	broad.mit.edu	37	1	32158705	32158705	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:32158705C>G	ENST00000373672.3	-	13	1575	c.1059G>C	c.(1057-1059)gaG>gaC	p.E353D	COL16A1_ENST00000271069.6_Missense_Mutation_p.E353D|COL16A1_ENST00000373668.3_Missense_Mutation_p.E353D	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	353	Nonhelical region 10 (NC10).				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		GTGCTCCCTTCTCTCCCTTGG	0.627000													3	13					0	0	1	0	0
FSD1	79187	broad.mit.edu	37	19	4318918	4318918	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:4318918C>T	ENST00000221856.6	+	10	1156	c.1009C>T	c.(1009-1011)Cgc>Tgc	p.R337C	FSD1_ENST00000598010.1_3'UTR|FSD1_ENST00000597590.1_Missense_Mutation_p.R337C	NM_024333.2	NP_077309.1	Q9BTV5	FSD1_HUMAN	fibronectin type III and SPRY domain containing 1	337	B30.2/SPRY.				cell division|mitosis	cleavage furrow|microtubule|microtubule organizing center|nucleus				breast(2)|cervix(1)|endometrium(1)|large_intestine(4)|liver(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.034)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGACGGGACCGCTTCACCGC	0.602000													26	42					0	0	1	0	0
TNFRSF1A	7132	broad.mit.edu	37	12	6439435	6439435	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:6439435C>T	ENST00000162749.2	-	8	1065	c.766G>A	c.(766-768)Gag>Aag	p.E256K	TNFRSF1A_ENST00000540022.1_Missense_Mutation_p.E213K	NM_001065.3	NP_001056.1	P19438	TNR1A_HUMAN	tumor necrosis factor receptor superfamily, member 1A	256					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|inflammatory response|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of inflammatory response|positive regulation of transcription from RNA polymerase II promoter|prostaglandin metabolic process	extracellular region|integral to plasma membrane|membrane raft	tumor necrosis factor receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	19						CATCTCACCTCTTTTTCAGGT	0.463000													12	136					0	0	1	0	0
MMP25	64386	broad.mit.edu	37	16	3108534	3108534	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr16:3108534G>A	ENST00000336577.4	+	9	1518	c.1281G>A	c.(1279-1281)aaG>aaA	p.K427K	RP11-473M20.7_ENST00000572222.1_RNA|RP11-473M20.7_ENST00000572574.1_RNA|RP11-473M20.7_ENST00000576250.1_RNA|RP11-473M20.7_ENST00000572427.1_RNA	NM_022468.4	NP_071913.1	Q9NPA2	MMP25_HUMAN	matrix metallopeptidase 25	427	Hemopexin-like 3.				inflammatory response|proteolysis	anchored to membrane|cell surface|plasma membrane|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	14						AGAACGGGAAGACCTACCTGG	0.751000													5	2					0	0	1	0	0
NMNAT2	23057	broad.mit.edu	37	1	183253136	183253136	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:183253136C>T	ENST00000287713.6	-	7	902	c.568G>A	c.(568-570)Gag>Aag	p.E190K	NMNAT2_ENST00000294868.4_Missense_Mutation_p.E185K|NMNAT2_ENST00000473046.1_5'UTR	NM_015039.3	NP_055854.1	Q9BZQ4	NMNA2_HUMAN	nicotinamide nucleotide adenylyltransferase 2	190					water-soluble vitamin metabolic process	Golgi membrane|nucleus	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(7)|skin(2)	18						TCACCAATCTCTTCATACCGC	0.532000													8	65					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33928582	33928582	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr15:33928582G>A	ENST00000389232.4	+	27	3457	c.3387G>A	c.(3385-3387)caG>caA	p.Q1129Q	RYR3_ENST00000415757.3_Silent_p.Q1129Q	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1129	4 X approximate repeats.|B30.2/SPRY 2.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCTAGGGCCAGCGTTGGCATC	0.483000													25	100					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32972863	32972863	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr13:32972863G>C	ENST00000544455.1	+	27	10440	c.10213G>C	c.(10213-10215)Gag>Cag	p.E3405Q	BRCA2_ENST00000380152.3_Missense_Mutation_p.E3405Q	NM_000059.3	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	3405					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		GGAAGAATGTGAGAAAAATAA	0.383000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			31	26					0	0	1	0	0
APOA4	337	broad.mit.edu	37	11	116692018	116692018	+	Silent	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:116692018G>C	ENST00000357780.3	-	3	870	c.756C>G	c.(754-756)ctC>ctG	p.L252L		NM_000482.3	NP_000473.2			apolipoprotein A-IV											cervix(1)|endometrium(2)|lung(10)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.62e-05)|all cancers(92;0.000165)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		TCCTGGCCTTGAGCTCCTCGG	0.662000													20	77					0	0	1	0	0
OR2F2	135948	broad.mit.edu	37	7	143632955	143632955	+	Silent	SNP	T	T	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr7:143632955T>C	ENST00000408955.2	+	1	697	c.630T>C	c.(628-630)ccT>ccC	p.P210P		NM_001004685.1	NP_001004685.1	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F, member 2	210					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(19)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	32	Melanoma(164;0.0903)					TGATGACACCTTTCTGCCTGG	0.507000													4	44					0	0	1	0	0
MFSD10	10227	broad.mit.edu	37	4	2932713	2932713	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr4:2932713G>A	ENST00000514800.1	-	11	1350	c.1327C>T	c.(1327-1329)Cgg>Tgg	p.R443W	MFSD10_ENST00000508221.1_3'UTR|MFSD10_ENST00000329687.4_Intron|MFSD10_ENST00000507555.1_Intron|MFSD10_ENST00000355443.4_Intron			Q14728	MFS10_HUMAN	major facilitator superfamily domain containing 10	0					apoptosis	integral to membrane	tetracycline transporter activity			breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|skin(1)	7				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CCCAGTCCCCGAGGGGGCTGG	0.716000													7	20					0	0	1	0	0
ZBTB26	57684	broad.mit.edu	37	9	125681329	125681329	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr9:125681329G>C	ENST00000373656.3	-	2	958	c.885C>G	c.(883-885)caC>caG	p.H295Q	ZBTB26_ENST00000373654.1_Missense_Mutation_p.H295Q	NM_020924.2	NP_065975.1	Q9HCK0	ZBT26_HUMAN	zinc finger and BTB domain containing 26	295					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(4)|prostate(1)	11						TAAAGAGTTTGTGCATTTTTA	0.473000													15	87					0	0	1	0	0
EFTUD2	9343	broad.mit.edu	37	17	42930716	42930716	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr17:42930716G>A	ENST00000426333.2	-	25	2806	c.2509C>T	c.(2509-2511)Cag>Tag	p.Q837*	EFTUD2_ENST00000402521.3_Nonsense_Mutation_p.Q802*|EFTUD2_ENST00000592576.1_Nonsense_Mutation_p.Q827*|EFTUD2_ENST00000591382.1_Nonsense_Mutation_p.Q837*	NM_001142605.1|NM_001258354.1|NM_004247.3	NP_001136077.1|NP_001245283.1|NP_004238.3	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain containing 2	837						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	32		Prostate(33;0.109)				GCAGGGGCCTGGACCTCTACA	0.587000													64	62					0	0	1	0	0
BTN2A3P	54718	broad.mit.edu	37	6	26422353	26422353	+	RNA	SNP	C	C	T	rs141013110		TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:26422353C>T	ENST00000466808.2	+	0	7																		p.P3S(2)									GCTCATGGAACCAGCTGCTGC	0.622000													4	54					0	0	1	0	0
GANAB	23193	broad.mit.edu	37	11	62397869	62397869	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:62397869C>G	ENST00000346178.4	-	13	1576	c.1561G>C	c.(1561-1563)Gag>Cag	p.E521Q	GANAB_ENST00000356638.3_Missense_Mutation_p.E499Q|GANAB_ENST00000540933.1_Missense_Mutation_p.E402Q|GANAB_ENST00000534779.1_Missense_Mutation_p.E407Q	NM_001278192.1|NM_198335.2	NP_001265121.1|NP_938149.2	Q14697	GANAB_HUMAN	glucosidase, alpha; neutral AB	499					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|skin(2)|urinary_tract(3)	35						CACCAGCCCTCATAGTCAGAG	0.572000													19	32					0	0	1	0	0
SOS1	6654	broad.mit.edu	37	2	39213112	39213112	+	Missense_Mutation	SNP	A	A	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr2:39213112A>C	ENST00000426016.1	-	24	3941	c.3855T>G	c.(3853-3855)caT>caG	p.H1285Q	SOS1_ENST00000395038.2_Missense_Mutation_p.H1270Q|SOS1_ENST00000402219.2_Missense_Mutation_p.H1285Q			Q07889	SOS1_HUMAN	son of sevenless homolog 1 (Drosophila)	1285					apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(29)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	75		all_hematologic(82;0.21)				CAGCAATGGAATGAAGGTCCA	0.517000									Noonan syndrome				41	60					0	0	1	0	0
OR2L8	391190	broad.mit.edu	37	1	248112481	248112481	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:248112481G>C	ENST00000357191.3	+	1	322	c.322G>C	c.(322-324)Ggt>Cgt	p.G108R	OR2L13_ENST00000366478.2_Intron	NM_001001963.1	NP_001001963.1	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)	108					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(30)|ovary(1)|prostate(1)|skin(3)	42	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			GGCATTAGGAGGTGCAGAAGC	0.438000													21	200					0	0	1	0	0
ZNF281	23528	broad.mit.edu	37	1	200376414	200376414	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:200376414G>C	ENST00000294740.3	-	2	2544	c.2420C>G	c.(2419-2421)tCt>tGt	p.S807C	ZNF281_ENST00000367353.1_Missense_Mutation_p.S807C|ZNF281_ENST00000367352.3_Missense_Mutation_p.S771C	NM_001281293.1|NM_001281294.1|NM_012482.4	NP_001268222.1|NP_001268223.1|NP_036614.1	Q9Y2X9	ZN281_HUMAN	zinc finger protein 281						negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			breast(4)|endometrium(3)|kidney(3)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	27						TAACTCCTGAGATGGAATCTG	0.418000													6	117					0	0	1	0	0
PLEKHG6	55200	broad.mit.edu	37	12	6435660	6435660	+	Silent	SNP	C	C	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:6435660C>A	ENST00000449001.2	+	13	1989	c.1495C>A	c.(1495-1497)Cgg>Agg	p.R499R	PLEKHG6_ENST00000396988.3_Silent_p.R531R|PLEKHG6_ENST00000304581.8_Silent_p.R61R|PLEKHG6_ENST00000011684.7_Silent_p.R531R	NM_001144857.1	NP_001138329.1	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	531	PH.				regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(4)	23						GACCCTCTATCGGGACCAGGA	0.597000													5	48					0.000602214	0.000614286	1	1	0
HIST1H2AK	8330	broad.mit.edu	37	6	27805892	27805892	+	Missense_Mutation	SNP	T	T	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:27805892T>C	ENST00000330180.2	-	1	225	c.226A>G	c.(226-228)Aag>Gag	p.K76E		NM_003510.2	NP_003501.1	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ak	76					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			breast(2)|endometrium(2)|kidney(1)|lung(3)|upper_aerodigestive_tract(2)	10						ATGCGGGTCTTCTTGTTGTCG	0.647000													35	105					0	0	1	0	0
INTS3	65123	broad.mit.edu	37	1	153730126	153730126	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:153730126C>T	ENST00000456435.1	+	10	1604	c.418C>T	c.(418-420)Cgc>Tgc	p.R140C	INTS3_ENST00000435409.2_Missense_Mutation_p.R346C|INTS3_ENST00000512605.1_Missense_Mutation_p.R140C|INTS3_ENST00000318967.2_Missense_Mutation_p.R346C|INTS3_ENST00000476843.1_3'UTR			Q68E01	INT3_HUMAN	integrator complex subunit 3	347					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			breast(1)|cervix(4)|endometrium(10)|kidney(1)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	38	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TCAGTCTCTGCGCTGTGACCT	0.512000													28	61					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38622661	38622661	+	Missense_Mutation	SNP	C	C	A	rs137854609		TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:38622661C>A	ENST00000413689.1	-	17	3182	c.2989G>T	c.(2989-2991)Gcc>Tcc	p.A997S	SCN5A_ENST00000449557.2_Missense_Mutation_p.A997S|SCN5A_ENST00000423572.2_Missense_Mutation_p.A997S|SCN5A_ENST00000414099.2_Missense_Mutation_p.A997S|SCN5A_ENST00000333535.4_Missense_Mutation_p.A997S|SCN5A_ENST00000455624.2_Missense_Mutation_p.A997S|SCN5A_ENST00000443581.1_Missense_Mutation_p.A997S|SCN5A_ENST00000425664.1_Missense_Mutation_p.A997S|SCN5A_ENST00000450102.2_Missense_Mutation_p.A997S|SCN5A_ENST00000451551.2_Missense_Mutation_p.A997S	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	997			A -> S (in LQT3; also found in patients with atrial fibrillation; sodium current characterized by slower decay and a 2- to 3-fold increase in late sodium current).		blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TGGCCCTGGGCGGCAAGGGCT	0.677000													12	6					5.16669e-11	5.54179e-11	1	1	0
FAM177A1	283635	broad.mit.edu	37	14	35550261	35550261	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr14:35550261G>A	ENST00000396472.1	+	7	928	c.469G>A	c.(469-471)Gaa>Aaa	p.E157K	FAM177A1_ENST00000382406.3_Missense_Mutation_p.E157K|FAM177A1_ENST00000280987.4_Missense_Mutation_p.E180K	NM_001079519.1	NP_001072987.1	Q8N128	F177A_HUMAN	family with sequence similarity 177, member A1	157										breast(1)|large_intestine(1)|lung(2)|urinary_tract(1)	5						CAGGATGTCTGAAGAAGCAGA	0.343000													12	11					0	0	1	0	0
TESK2	10420	broad.mit.edu	37	1	45813651	45813651	+	Missense_Mutation	SNP	C	C	T	rs145725484	by1000genomes	TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:45813651C>T	ENST00000372086.3	-	6	962	c.562G>A	c.(562-564)Gag>Aag	p.E188K	TESK2_ENST00000486676.1_5'UTR|TESK2_ENST00000372084.1_Missense_Mutation_p.E188K|TESK2_ENST00000538496.1_Missense_Mutation_p.E105K|TESK2_ENST00000341771.6_Missense_Mutation_p.E188K	NM_007170.2	NP_009101.2	Q96S53	TESK2_HUMAN	testis-specific kinase 2	188	Protein kinase.				actin cytoskeleton organization|focal adhesion assembly|spermatogenesis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(1)|lung(9)|ovary(2)|pancreas(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	32	Acute lymphoblastic leukemia(166;0.155)					TAACCATTCTCATCCCTCTTT	0.537000													9	28					0	0	1	0	0
HIPK3	10114	broad.mit.edu	37	11	33373799	33373799	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:33373799G>C	ENST00000303296.4	+	16	3464	c.3159G>C	c.(3157-3159)ttG>ttC	p.L1053F	HIPK3_ENST00000525975.1_Missense_Mutation_p.L1032F|HIPK3_ENST00000456517.1_Missense_Mutation_p.L1032F|HIPK3_ENST00000379016.3_Missense_Mutation_p.L1032F	NM_005734.3	NP_005725.3	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3	1053					anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			endometrium(3)|kidney(3)|large_intestine(9)|liver(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	39						AGCAGCATTTGAACTTCAGTC	0.423000													46	98					0	0	1	0	0
SSX6	280657	broad.mit.edu	37	X	47979503	47979503	+	RNA	SNP	C	C	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chrX:47979503C>A	ENST00000509958.1	+	0	247																				large_intestine(6)|lung(4)|skin(2)|stomach(1)	13						CGACACATGCCCATGATGAGA	0.522000													45	17					4.44712e-29	4.90791e-29	1	1	0
NEO1	4756	broad.mit.edu	37	15	73580826	73580826	+	Missense_Mutation	SNP	C	C	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr15:73580826C>A	ENST00000339362.5	+	25	4030	c.3583C>A	c.(3583-3585)Caa>Aaa	p.Q1195K	NEO1_ENST00000560262.1_Missense_Mutation_p.Q1195K|NEO1_ENST00000558964.1_Missense_Mutation_p.Q1184K|NEO1_ENST00000261908.6_Missense_Mutation_p.Q1195K			Q92859	NEO1_HUMAN	neogenin 1	1195					axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(9)|lung(26)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	57						TCGCAACTCTCAAGATATCAC	0.428000													14	82					6.81908e-15	7.36589e-15	1	1	0
CSMD3	114788	broad.mit.edu	37	8	113246662	113246662	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr8:113246662G>A	ENST00000297405.5	-	68	10916	c.10672C>T	c.(10672-10674)Ctt>Ttt	p.L3558F	CSMD3_ENST00000352409.3_Missense_Mutation_p.L3488F|CSMD3_ENST00000343508.3_Missense_Mutation_p.L3518F|CSMD3_ENST00000455883.2_Missense_Mutation_p.L3389F	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3558						integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						ACTTTAATAAGATATATGCGT	0.343000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			61	111					0	0	1	0	0
TADA2A	6871	broad.mit.edu	37	17	35804846	35804846	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr17:35804846G>C	ENST00000394395.2	+	8	753	c.580G>C	c.(580-582)Gaa>Caa	p.E194Q	TADA2A_ENST00000586023.1_Missense_Mutation_p.E194Q|TADA2A_ENST00000591992.1_3'UTR|TADA2A_ENST00000417170.1_Missense_Mutation_p.E194Q|TADA2A_ENST00000225396.6_Missense_Mutation_p.E194Q	NM_001166105.1	NP_001159577.1	O75478	TAD2A_HUMAN	transcriptional adaptor 2A	194					histone H3 acetylation|transcription from RNA polymerase II promoter	chromosome|PCAF complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|zinc ion binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|lung(3)|prostate(1)|skin(1)	13						TGATTTTGTTGAAGATGACTC	0.403000													32	307					0	0	1	0	0
DGKZ	8525	broad.mit.edu	37	11	46400035	46400035	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:46400035G>A	ENST00000454345.1	+	28	3092	c.2967G>A	c.(2965-2967)agG>agA	p.R989R	DGKZ_ENST00000532868.2_Silent_p.R805R|DGKZ_ENST00000343674.6_Silent_p.R817R|DGKZ_ENST00000318201.8_Silent_p.R778R|DGKZ_ENST00000456247.2_Silent_p.R800R|DGKZ_ENST00000395574.3_Silent_p.R767R|DGKZ_ENST00000527911.1_Silent_p.R801R|DGKZ_ENST00000528615.1_Silent_p.R579R|DGKZ_ENST00000421244.2_Silent_p.R801R|DGKZ_ENST00000543978.1_Silent_p.R153R	NM_001105540.1	NP_001099010.1	Q13574	DGKZ_HUMAN	diacylglycerol kinase, zeta	989					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|pancreas(1)|prostate(1)|skin(1)	25				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		CTGCCAAGAGGAACGACTTCT	0.612000													7	29					0	0	1	0	0
SLC7A10	56301	broad.mit.edu	37	19	33703796	33703796	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:33703796G>A	ENST00000253188.4	-	3	615	c.469C>T	c.(469-471)Ccc>Tcc	p.P157S		NM_019849.2	NP_062823.1	Q9NS82	AAA1_HUMAN	solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10						blood coagulation|cellular nitrogen compound metabolic process|ion transport|leukocyte migration	integral to plasma membrane	L-serine transmembrane transporter activity			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|stomach(1)	18	Esophageal squamous(110;0.137)					GCTGTGGTGGGGGGGATGCAG	0.637000													25	41					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60893602	60893602	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr20:60893602C>T	ENST00000252999.3	-	53	7213	c.7147G>A	c.(7147-7149)Gac>Aac	p.D2383N		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	2383	Domain II and I.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCTCGCAGGTCCATGAGGCCG	0.692000													13	94					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33156946	33156946	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:33156946G>C	ENST00000341947.2	-	3	479	c.252C>G	c.(250-252)ttC>ttG	p.F84L	COL11A2_ENST00000357486.1_Missense_Mutation_p.F84L|COL11A2_ENST00000361917.1_Missense_Mutation_p.F84L|COL11A2_ENST00000374708.4_Missense_Mutation_p.F84L|COL11A2_ENST00000374712.1_Missense_Mutation_p.F84L|COL11A2_ENST00000395194.1_Missense_Mutation_p.F84L|COL11A2_ENST00000374713.1_Missense_Mutation_p.F84L|COL11A2_ENST00000395197.1_Missense_Mutation_p.F84L|COL11A2_ENST00000374714.1_Missense_Mutation_p.F84L	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	84	TSP N-terminal.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						TCAGCAGAGAGAAATCTTTGG	0.587000													5	26					0	0	1	0	0
KCNC3	3748	broad.mit.edu	37	19	50831754	50831754	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:50831754C>T	ENST00000376959.2	-	1	749	c.586G>A	c.(586-588)Gag>Aag	p.E196K	KCNC3_ENST00000474951.1_Intron|KCNC3_ENST00000477616.1_Missense_Mutation_p.E196K|KCNC3_ENST00000391818.2_Intron			Q14003	KCNC3_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 3	196					cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(2)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)	13		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		AGCGCCTCCTCAGCGTCGCGA	0.731000													7	23					0	0	1	0	0
HADH	3033	broad.mit.edu	37	4	108935710	108935710	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr4:108935710G>A	ENST00000505878.1	+	4	670	c.397G>A	c.(397-399)Gag>Aag	p.E133K	HADH_ENST00000603302.1_Missense_Mutation_p.E129K|HADH_ENST00000403312.1_Missense_Mutation_p.E188K|HADH_ENST00000454409.2_Missense_Mutation_p.E133K|HADH_ENST00000309522.3_Missense_Mutation_p.E129K			Q16836	HCDH_HUMAN	hydroxyacyl-CoA dehydrogenase	129					fatty acid beta-oxidation	mitochondrial matrix	3-hydroxyacyl-CoA dehydrogenase activity|NAD+ binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	15		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000168)	NADH(DB00157)	GGTGAAAAACGAGCTCTTCAA	0.433000													33	61					0	0	1	0	0
TIFAB	497189	broad.mit.edu	37	5	134785149	134785149	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr5:134785149C>G	ENST00000537858.1	-	2	681	c.481G>C	c.(481-483)Ggg>Cgg	p.G161R		NM_001099221.1	NP_001092691.1	Q6ZNK6	TIFAB_HUMAN	TRAF-interacting protein with forkhead-associated domain, family member B	161										breast(1)|endometrium(1)|liver(1)|lung(5)	8			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ATCTGCTACCCTGAACCAGGG	0.577000													8	42					0	0	1	0	0
ZHX1-C8ORF76	100533106	broad.mit.edu	37	8	124238725	124238725	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr8:124238725G>A	ENST00000357082.4	-	5	960	c.867C>T	c.(865-867)ctC>ctT	p.L289L	C8orf76_ENST00000276704.4_Intron	NM_001204180.1	NP_001191109.1																					ACATAAACCCGAGGGATACAC	0.403000													32	65					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100679927	100679927	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr7:100679927C>T	ENST00000306151.4	+	3	5294	c.5230C>T	c.(5230-5232)Cct>Tct	p.P1744S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1744	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AAACTCAACTCCTAGTGAAGG	0.493000													28	386					0	0	1	0	0
MUSK	4593	broad.mit.edu	37	9	113530265	113530265	+	Silent	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr9:113530265G>C	ENST00000416899.2	+	8	1212	c.1086G>C	c.(1084-1086)gtG>gtC	p.V362V	MUSK_ENST00000374448.4_Silent_p.V362V|MUSK_ENST00000189978.5_Silent_p.V362V			O15146	MUSK_HUMAN	muscle, skeletal, receptor tyrosine kinase	362	FZ.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(23)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	49						TGAAAGTAGTGAGCCCAGTCT	0.532000													36	17					0	0	1	0	0
EP300	2033	broad.mit.edu	37	22	41531855	41531855	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr22:41531855C>T	ENST00000263253.7	+	7	2786	c.1567C>T	c.(1567-1569)Caa>Taa	p.Q523*		NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	523					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						TGTAGGAGTTCAAACGCCGAG	0.373000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				19	45					0	0	1	0	0
CDKAL1	54901	broad.mit.edu	37	6	20846385	20846385	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:20846385G>A	ENST00000274695.4	+	9	885	c.718G>A	c.(718-720)Gat>Aat	p.D240N	CDKAL1_ENST00000378610.1_Missense_Mutation_p.D240N|CDKAL1_ENST00000378624.4_Missense_Mutation_p.D170N	NM_017774.3	NP_060244.2	Q5VV42	CDKAL_HUMAN	CDK5 regulatory subunit associated protein 1-like 1	240					RNA modification	integral to membrane	4 iron, 4 sulfur cluster binding|metal ion binding|transferase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|stomach(1)	29	all_epithelial(95;0.0708)|Breast(50;0.131)|Ovarian(93;0.227)		OV - Ovarian serous cystadenocarcinoma(7;0.0241)|all cancers(50;0.123)|Epithelial(50;0.248)			TGAACTAGTAGATAGAGCCAA	0.323000													20	53					0	0	1	0	0
ABI3	51225	broad.mit.edu	37	17	47297583	47297583	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr17:47297583C>G	ENST00000225941.1	+	6	1195	c.697C>G	c.(697-699)Cca>Gca	p.P233A	ABI3_ENST00000419580.2_Missense_Mutation_p.P227A	NM_001135186.1|NM_016428.2	NP_001128658.1|NP_057512	Q9P2A4	ABI3_HUMAN	ABI family, member 3	233	Pro-rich.				cellular component movement|regulation of cell migration	cytoplasm|lamellipodium	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	12			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)			GGCAGCACCTCCAGCCCCACC	0.697000										HNSCC(55;0.14)			13	9					0	0	1	0	0
SGK3	23678	broad.mit.edu	37	8	67771704	67771704	+	Missense_Mutation	SNP	A	A	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr8:67771704A>G	ENST00000396596.1	+	17	1593	c.1379A>G	c.(1378-1380)tAt>tGt	p.Y460C	SGK3_ENST00000522398.1_Missense_Mutation_p.Y460C|SGK3_ENST00000345714.4_Missense_Mutation_p.Y460C|SGK3_ENST00000520976.1_Missense_Mutation_p.Y428C|SGK3_ENST00000521198.2_Missense_Mutation_p.Y460C|C8orf44-SGK3_ENST00000519289.1_Missense_Mutation_p.Y460C	NM_013257.4	NP_037389.4	Q96BR1	SGK3_HUMAN	serum/glucocorticoid regulated kinase family, member 3	460	AGC-kinase C-terminal.				cell communication|response to stress	cytoplasmic membrane-bounded vesicle|early endosome	ATP binding|phosphatidylinositol binding|protein serine/threonine kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	18	Breast(64;0.186)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0046)|OV - Ovarian serous cystadenocarcinoma(28;0.0112)|all cancers(69;0.0141)|BRCA - Breast invasive adenocarcinoma(89;0.206)			ACAGTTCCATATTCTGTGTGT	0.388000													50	110					0	0	1	0	0
DMXL1	1657	broad.mit.edu	37	5	118503486	118503486	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr5:118503486G>C	ENST00000311085.8	+	23	5405	c.5325G>C	c.(5323-5325)atG>atC	p.M1775I	DMXL1_ENST00000539542.1_Missense_Mutation_p.M1775I	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1775										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TTCGGAGCATGGCATATTGGA	0.353000													12	25					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29770653	29770653	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr10:29770653C>T	ENST00000375398.2	-	30	5409	c.4960G>A	c.(4960-4962)Gga>Aga	p.G1654R	PTCHD3P1_ENST00000413405.1_RNA|PTCHD3P1_ENST00000414457.1_RNA|PTCHD3P1_ENST00000423223.1_RNA|SVIL_ENST00000375400.3_Missense_Mutation_p.G1228R|SVIL_ENST00000538146.1_Missense_Mutation_p.G446R|SVIL_ENST00000535393.1_Missense_Mutation_p.G568R|PTCHD3P1_ENST00000446807.1_RNA|SVIL_ENST00000355867.4_Missense_Mutation_p.G1654R			O95425	SVIL_HUMAN	supervillin	1654	Interaction with NEB.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				CGCCCCTGTCCTTTTCTGTAG	0.488000													67	180					0	0	1	0	0
ANKHD1	54882	broad.mit.edu	37	5	139909073	139909073	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr5:139909073C>T	ENST00000297183.6	+	29	6666	c.6542C>T	c.(6541-6543)tCa>tTa	p.S2181L	ANKHD1_ENST00000544120.1_Missense_Mutation_p.S564L|ANKHD1-EIF4EBP3_ENST00000532219.1_Missense_Mutation_p.S2181L|ANKHD1_ENST00000360839.2_Missense_Mutation_p.S2181L	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGCTTTCTTCAGCTGTGAAC	0.448000													30	67					0	0	1	0	0
NIPA2	81614	broad.mit.edu	37	15	23019802	23019802	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr15:23019802G>C	ENST00000337451.3	-	5	806	c.194C>G	c.(193-195)tCa>tGa	p.S65*	NIPA2_ENST00000359727.4_Intron|NIPA2_ENST00000398013.3_Nonsense_Mutation_p.S65*|NIPA2_ENST00000398014.2_Nonsense_Mutation_p.S65*|NIPA2_ENST00000539711.2_Intron	NM_030922.6	NP_112184.4	Q8N8Q9	NIPA2_HUMAN	non imprinted in Prader-Willi/Angelman syndrome 2	65						early endosome|integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(2)|prostate(4)|skin(1)	15		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;1.48e-06)|Epithelial(43;1.44e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000353)		ATACATACTTGACAGCAGTCC	0.343000													16	65					0	0	1	0	0
CXADR	1525	broad.mit.edu	37	21	18919367	18919367	+	Silent	SNP	C	C	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr21:18919367C>A	ENST00000284878.7	+	2	814	c.66C>A	c.(64-66)atC>atA	p.I22I	CXADR_ENST00000400169.1_Silent_p.I22I|CXADR_ENST00000306618.10_Silent_p.I22I|CXADR_ENST00000400166.1_Silent_p.I22I|CXADR_ENST00000400165.1_Silent_p.I22I|CXADR_ENST00000356275.6_Silent_p.I22I	NM_001338.4	NP_001329.1	P78310	CXAR_HUMAN	coxsackie virus and adenovirus receptor	22	Ig-like C2-type 1.				blood coagulation|cell adhesion|interspecies interaction between organisms|leukocyte migration|regulation of immune response	adherens junction|basolateral plasma membrane|extracellular region|integral to plasma membrane|nucleus|tight junction	receptor activity			endometrium(2)|large_intestine(5)|lung(1)|ovary(1)|prostate(2)	11				Epithelial(23;0.000206)|all cancers(11;0.000302)|OV - Ovarian serous cystadenocarcinoma(11;0.0194)|Lung(58;0.0233)|COAD - Colon adenocarcinoma(22;0.0389)|Colorectal(24;0.0483)|LUSC - Lung squamous cell carcinoma(23;0.0782)		GTTTGAGTATCACTACTCCTG	0.478000													40	36					8.01111e-26	8.81992e-26	1	1	0
KMT2D	8085	broad.mit.edu	37	12	49415887	49415887	+	Missense_Mutation	SNP	G	G	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:49415887G>T	ENST00000301067.7	-	53	16459	c.16460C>A	c.(16459-16461)aCa>aAa	p.T5487K		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		TTTGTCAAATGTCACGACTTC	0.502000													22	168					1.9806e-07	2.07578e-07	1	1	0
PRCC	5546	broad.mit.edu	37	1	156756611	156756611	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:156756611C>G	ENST00000271526.4	+	3	1000	c.728C>G	c.(727-729)tCt>tGt	p.S243C	PRCC_ENST00000491853.1_3'UTR|PRCC_ENST00000353233.3_Missense_Mutation_p.S243C	NM_005973.4	NP_005964.3	Q92733	PRCC_HUMAN	papillary renal cell carcinoma (translocation-associated)	243					cell cycle|mitotic cell cycle checkpoint	nucleus	protein binding		PRCC/TFE3(25)	breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(1)|liver(1)|lung(5)|upper_aerodigestive_tract(1)	15	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCGTCGCCCTCTGCTATCAAG	0.557000			T	TFE3	papillary renal								10	51					0	0	1	0	0
ODF3L1	161753	broad.mit.edu	37	15	76019520	76019520	+	Missense_Mutation	SNP	A	A	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr15:76019520A>G	ENST00000332145.2	+	4	687	c.464A>G	c.(463-465)aAc>aGc	p.N155S		NM_175881.3	NP_787077.1	Q8IXM7	OD3L1_HUMAN	outer dense fiber of sperm tails 3-like 1	155										kidney(1)|lung(1)	2						ATGGACCTCAACCCGGCTCCC	0.612000													37	75					0	0	1	0	0
MYPN	84665	broad.mit.edu	37	10	69926378	69926378	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr10:69926378C>G	ENST00000358913.5	+	10	2416	c.1928C>G	c.(1927-1929)tCt>tGt	p.S643C	MYPN_ENST00000540630.1_Missense_Mutation_p.S643C|MYPN_ENST00000354393.2_Missense_Mutation_p.S368C	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	643						nucleus|sarcomere	actin binding			breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						CCAGAGCCTTCTTCCCCCGTG	0.512000													14	50					0	0	1	0	0
GALNT12	79695	broad.mit.edu	37	9	101611249	101611249	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr9:101611249C>T	ENST00000375011.3	+	10	1621	c.1621C>T	c.(1621-1623)Cac>Tac	p.H541Y	GALNT12_ENST00000470473.1_3'UTR|RP11-92C4.3_ENST00000589257.1_RNA|RP11-92C4.3_ENST00000433997.1_RNA	NM_024642.4	NP_078918.3	Q8IXK2	GLT12_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)	541	Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding	p.H541N(1)|p.H541Y(1)		breast(1)|endometrium(2)|large_intestine(3)|lung(8)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	17		Acute lymphoblastic leukemia(62;0.0559)				ATCTTTATTTCACGAACAGTC	0.423000											OREG0019361	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	9					0	0	1	0	0
TRAPPC10	7109	broad.mit.edu	37	21	45499917	45499917	+	Silent	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr21:45499917C>G	ENST00000291574.4	+	13	1807	c.1632C>G	c.(1630-1632)ctC>ctG	p.L544L		NM_003274.4	NP_003265.3	P48553	TPC10_HUMAN	trafficking protein particle complex 10	544					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity	p.L544L(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(8)|ovary(1)|prostate(2)|skin(2)|urinary_tract(4)	41						CCAGCAGCCTCTTAGCCAGTG	0.582000													7	17					0	0	1	0	0
DDX50	79009	broad.mit.edu	37	10	70706348	70706348	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr10:70706348C>T	ENST00000373585.3	+	15	2283	c.2176C>T	c.(2176-2178)Cga>Tga	p.R726*		NM_024045.1	NP_076950.1	Q9BQ39	DDX50_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 50	726	Arg-rich.					nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	29						GAATAGAAATCGATCAAGAAG	0.473000													17	82					0	0	1	0	0
ADGRG1	9289	broad.mit.edu	37	16	57693318	57693318	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr16:57693318C>T	ENST00000388812.4	+	11	1738	c.1298C>T	c.(1297-1299)cCg>cTg	p.P433L	GPR56_ENST00000567835.1_Missense_Mutation_p.P433L|GPR56_ENST00000562558.1_Intron|GPR56_ENST00000379694.4_Missense_Mutation_p.P263L|GPR56_ENST00000568909.1_Missense_Mutation_p.P433L|GPR56_ENST00000456916.1_Missense_Mutation_p.P433L|GPR56_ENST00000562631.1_Intron|GPR56_ENST00000388813.5_Intron|GPR56_ENST00000540164.2_Intron|GPR56_ENST00000544297.1_Intron|GPR56_ENST00000379696.3_Missense_Mutation_p.P433L|GPR56_ENST00000568908.1_Intron|GPR56_ENST00000538815.1_Intron			Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56	433					brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity			kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)	15						GTGCCCCTGCCGTGCAGGAGG	0.642000													8	52					0	0	1	0	0
ZNF716	441234	broad.mit.edu	37	7	57509974	57509974	+	Translation_Start_Site	SNP	C	C	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr7:57509974C>A	ENST00000420713.1	+	0	92					NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						GGCCTTGTGTCCTGCAAGTAT	0.572000													10	15					7.48243e-07	7.82409e-07	1	1	0
EXOSC10	5394	broad.mit.edu	37	1	11155874	11155874	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:11155874C>T	ENST00000544779.1	-	3	318	c.313G>A	c.(313-315)Gag>Aag	p.E105K	EXOSC10_ENST00000376936.4_Missense_Mutation_p.E105K|EXOSC10_ENST00000304457.7_Missense_Mutation_p.E105K			Q01780	EXOSX_HUMAN	exosome component 10	105					CUT catabolic process|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear polyadenylation-dependent rRNA catabolic process|nuclear retention of unspliced pre-mRNA at the site of transcription|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5' exonuclease activity|exoribonuclease activity|identical protein binding|nucleotide binding|protein serine/threonine kinase activity|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|stomach(3)|upper_aerodigestive_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.18e-07)|COAD - Colon adenocarcinoma(227;8.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000315)|Kidney(185;0.000832)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|READ - Rectum adenocarcinoma(331;0.0526)|STAD - Stomach adenocarcinoma(313;0.202)		TCTTCCAGCTCAGTCACTTTA	0.383000													40	106					0	0	1	0	0
NFATC3	4775	broad.mit.edu	37	16	68156314	68156314	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr16:68156314C>G	ENST00000349223.5	+	2	752	c.528C>G	c.(526-528)ttC>ttG	p.F176L	NFATC3_ENST00000535127.2_3'UTR|NFATC3_ENST00000346183.3_Missense_Mutation_p.F176L|NFATC3_ENST00000575270.1_Missense_Mutation_p.F176L|NFATC3_ENST00000329524.4_Missense_Mutation_p.F176L	NM_173163.2	NP_775186.1	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	176					inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	44		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		GGAGTTGGTTCTCTGATGCAT	0.473000													10	81					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187542921	187542921	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr4:187542921C>A	ENST00000441802.2	-	10	5028	c.4819G>T	c.(4819-4821)Gga>Tga	p.G1607*		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	1607	Cadherin 14.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						AAAGAATTTCCAATATTTCCT	0.343000										HNSCC(5;0.00058)			4	10					0.00909568	0.00919607	1	1	0
CPA6	57094	broad.mit.edu	37	8	68536464	68536464	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr8:68536464G>C	ENST00000297770.4	-	2	354	c.139C>G	c.(139-141)Ccc>Gcc	p.P47A	CPA6_ENST00000297769.4_5'UTR|CPA6_ENST00000518549.1_Missense_Mutation_p.P47A	NM_020361.4	NP_065094.3	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6	47					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(5)	26			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			TCTGTTTTGGGAATAAATCTT	0.303000													11	41					0	0	1	0	0
PTCH1	5727	broad.mit.edu	37	9	98270508	98270508	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr9:98270508C>T	ENST00000331920.6	-	1	435	c.136G>A	c.(136-138)Gac>Aac	p.D46N	PTCH1_ENST00000375274.2_Intron|PTCH1_ENST00000430669.2_Intron|PTCH1_ENST00000468211.2_Intron|PTCH1_ENST00000437951.1_Intron	NM_000264.3	NP_000255.2	Q13635	PTC1_HUMAN	patched 1	46					embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			NS(8)|bone(33)|breast(10)|central_nervous_system(95)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(8)|kidney(2)|large_intestine(18)|lung(22)|meninges(1)|oesophagus(3)|ovary(6)|prostate(2)|skin(262)|upper_aerodigestive_tract(11)|urinary_tract(2)|vulva(1)	490		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				TAGTCCCGGTCCGGCGCGGCA	0.711000													14	14					0	0	1	0	0
LRRC49	54839	broad.mit.edu	37	15	71341840	71341840	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr15:71341840G>A	ENST00000260382.5	+	16	2210	c.1950G>A	c.(1948-1950)caG>caA	p.Q650Q	LRRC49_ENST00000560158.2_Silent_p.Q338Q|LRRC49_ENST00000560369.1_Silent_p.Q655Q|LRRC49_ENST00000544974.2_Silent_p.Q640Q|LRRC49_ENST00000443425.2_Silent_p.Q606Q|LRRC49_ENST00000436542.2_3'UTR|LRRC49_ENST00000560691.1_Silent_p.Q356Q	NM_001199017.1|NM_017691.3	NP_001185946.1|NP_060161.2	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	650						cytoplasm|microtubule				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|lung(14)|ovary(2)|prostate(3)|skin(3)	34						AGGCTTTGCAGAAGCTTTGGC	0.363000													23	89					0	0	1	0	0
TRPV4	59341	broad.mit.edu	37	12	110252505	110252505	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:110252505G>A	ENST00000418703.2	-	1	191	c.97C>T	c.(97-99)Ctc>Ttc	p.L33F	TRPV4_ENST00000544971.1_Missense_Mutation_p.L33F|TRPV4_ENST00000536570.1_Intron|TRPV4_ENST00000261740.2_Missense_Mutation_p.L33F|TRPV4_ENST00000537083.1_Missense_Mutation_p.L33F|TRPV4_ENST00000536838.1_Intron|TRPV4_ENST00000346520.2_Missense_Mutation_p.L33F|TRPV4_ENST00000541794.1_Missense_Mutation_p.L33F|TRPV4_ENST00000392719.2_Missense_Mutation_p.L33F	NM_001177431.1	NP_001170902.1	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel, subfamily V, member 4	33					actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding	p.L33F(1)		breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(2)|skin(4)|stomach(1)	35						AGGGAGGAGAGAGGAAAAGCC	0.687000													7	5					0	0	1	0	0
ALG1L	200810	broad.mit.edu	37	3	125651513	125651513	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:125651513G>A	ENST00000340333.3	-	3	303	c.140C>T	c.(139-141)tCt>tTt	p.S47F		NM_001015050.2|NM_001195223.1	NP_001015050.2|NP_001182152.1	Q6GMV1	ALG1L_HUMAN	ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like	47							transferase activity, transferring glycosyl groups			large_intestine(2)|lung(2)	4						ACAGACAAGAGAAGGAAGGTT	0.433000													12	60					0	0	1	0	0
BAZ2B	29994	broad.mit.edu	37	2	160303429	160303429	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr2:160303429G>C	ENST00000392783.2	-	6	1055	c.560C>G	c.(559-561)tCt>tGt	p.S187C	BAZ2B_ENST00000355831.2_Missense_Mutation_p.S187C|BAZ2B_ENST00000343439.5_Missense_Mutation_p.S185C|BAZ2B_ENST00000392782.1_Missense_Mutation_p.S185C	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	187	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						GGATAGTACAGATGTGTTGAT	0.328000													26	72					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22150834	22150834	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:22150834G>A	ENST00000374695.3	-	94	12859	c.12780C>T	c.(12778-12780)atC>atT	p.I4260I	LDLRAD2_ENST00000344642.2_3'UTR|HSPG2_ENST00000486901.1_5'UTR	NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	4260	Laminin G-like 3.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GCCCGAGGCTGATGAAGTCCT	0.677000													20	59					0	0	1	0	0
USP37	57695	broad.mit.edu	37	2	219374852	219374852	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr2:219374852G>A	ENST00000258399.3	-	11	1287	c.875C>T	c.(874-876)tCa>tTa	p.S292L	USP37_ENST00000415516.1_Missense_Mutation_p.S220L|USP37_ENST00000418019.1_Missense_Mutation_p.S292L|USP37_ENST00000454775.1_Missense_Mutation_p.S292L	NM_020935.2	NP_065986	Q86T82	UBP37_HUMAN	ubiquitin specific peptidase 37	292					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(2)|breast(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|skin(5)|stomach(1)	35		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)		AGTCTGGCTTGAAACATTAGT	0.348000													43	55					0	0	1	0	0
IFT172	26160	broad.mit.edu	37	2	27672596	27672596	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr2:27672596C>G	ENST00000260570.3	-	37	4225	c.4122G>C	c.(4120-4122)tgG>tgC	p.W1374C		NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	1374					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					TCGCCTTGTTCCACTCCTCAC	0.478000													28	71					0	0	1	0	0
FRMD8	83786	broad.mit.edu	37	11	65167226	65167226	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:65167226G>A	ENST00000317568.5	+	8	986	c.823G>A	c.(823-825)Gag>Aag	p.E275K	FRMD8_ENST00000355991.5_Missense_Mutation_p.E219K|FRMD8_ENST00000416776.2_Missense_Mutation_p.E241K	NM_031904.3	NP_114110.1	Q9BZ67	FRMD8_HUMAN	FERM domain containing 8	275	FERM.					cytoskeleton	binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|urinary_tract(1)	17						CTTCCACGGTGAGGTTGACAA	0.632000													18	23					0	0	1	0	0
SUSD5	26032	broad.mit.edu	37	3	33216542	33216542	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:33216542G>A	ENST00000309558.3	-	4	851	c.434C>T	c.(433-435)tCg>tTg	p.S145L		NM_015551.1	NP_056366.1	O60279	SUSD5_HUMAN	sushi domain containing 5	145	Sushi.				cell adhesion	integral to membrane	hyaluronic acid binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						GTGTGGGAACGAAGGCGGGTC	0.547000													18	34					0	0	1	0	0
L3MBTL1	26013	broad.mit.edu	37	20	42143791	42143791	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr20:42143791C>G	ENST00000444063.1	+	2	507	c.375C>G	c.(373-375)ttC>ttG	p.F125L	L3MBTL1_ENST00000418998.1_Missense_Mutation_p.F193L|L3MBTL1_ENST00000427442.2_Missense_Mutation_p.F193L|L3MBTL1_ENST00000457824.1_3'UTR|L3MBTL1_ENST00000373135.3_Missense_Mutation_p.F125L|L3MBTL1_ENST00000373134.1_Missense_Mutation_p.F125L			Q9Y468	LMBL1_HUMAN	l(3)mbt-like 1 (Drosophila)	125					chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|large_intestine(3)|ovary(1)|skin(2)	7						CTCAGCTGTTCCAGGAGCGGT	0.617000													25	31					0	0	1	0	0
PCDHB6	56130	broad.mit.edu	37	5	140531505	140531505	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr5:140531505C>G	ENST00000231136.1	+	1	1667	c.1667C>G	c.(1666-1668)tCg>tGg	p.S556W	PCDHB6_ENST00000543635.1_Missense_Mutation_p.S420W	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		556	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AACGACAACTCGCCCTTCGTG	0.706000													16	44					0	0	1	0	0
LOC220729	220729	broad.mit.edu	37	3	197348634	197348634	+	RNA	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:197348634G>C	ENST00000418868.1	-	0	625					NR_003266.2																						CAGCAGCACCGATGGGCCTGC	0.542000													4	75					0	0	1	0	0
STON1	11037	broad.mit.edu	37	2	48808101	48808101	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr2:48808101C>T	ENST00000309835.3	+	1	339	c.329C>T	c.(328-330)tCa>tTa	p.S110L	STON1_ENST00000404752.1_Missense_Mutation_p.S110L|STON1-GTF2A1L_ENST00000394754.1_Missense_Mutation_p.S110L|STON1-GTF2A1L_ENST00000402114.2_Missense_Mutation_p.S110L|STON1-GTF2A1L_ENST00000394751.3_Missense_Mutation_p.S110L|STON1-GTF2A1L_ENST00000405008.1_Missense_Mutation_p.S110L|STON1_ENST00000406226.1_Missense_Mutation_p.S110L|STON1-GTF2A1L_ENST00000309827.2_Missense_Mutation_p.S110L					stonin 1											NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(19)|prostate(3)|skin(2)	37		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GAATCATCTTCAGACAGCCCA	0.468000													11	49					0	0	1	0	0
UBC	7316	broad.mit.edu	37	12	125396371	125396371	+	Missense_Mutation	SNP	C	C	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:125396371C>A	ENST00000536769.1	-	1	3523	c.1947G>T	c.(1945-1947)caG>caT	p.Q649H	UBC_ENST00000538617.1_Missense_Mutation_p.Q269H|UBC_ENST00000339647.5_Missense_Mutation_p.Q649H|UBC_ENST00000546120.1_Missense_Mutation_p.Q573H			P0CG48	UBC_HUMAN	ubiquitin C	649	Ubiquitin-like 9.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(3)|endometrium(4)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		AGATCAACCTCTGCTGATCAG	0.527000													69	109					9.21137e-24	1.00928e-23	1	1	0
TIPIN	54962	broad.mit.edu	37	15	66629481	66629481	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr15:66629481C>T	ENST00000261881.4	-	8	806	c.721G>A	c.(721-723)Gag>Aag	p.E241K	TIPIN_ENST00000367709.4_Missense_Mutation_p.E140K	NM_017858.2	NP_060328	Q9BVW5	TIPIN_HUMAN	TIMELESS interacting protein	241					cell division|DNA replication checkpoint|intra-S DNA damage checkpoint|mitosis|positive regulation of cell proliferation|regulation of DNA replication involved in S phase|replication fork protection	cytoplasm|nuclear chromatin	protein binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	7						GTATTAACCTCTTCAACCGTG	0.358000													9	82					0	0	1	0	0
TP53BP1	7158	broad.mit.edu	37	15	43705449	43705449	+	Missense_Mutation	SNP	C	C	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr15:43705449C>A	ENST00000263801.3	-	24	5410	c.5158G>T	c.(5158-5160)Ggg>Tgg	p.G1720W	TP53BP1_ENST00000450115.2_Missense_Mutation_p.G1723W|TP53BP1_ENST00000382039.3_Missense_Mutation_p.G1675W|TP53BP1_ENST00000382044.4_Missense_Mutation_p.G1725W	NM_005657.2	NP_005648.1	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1	1720					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			breast(4)|endometrium(5)|kidney(7)|large_intestine(22)|lung(13)|ovary(4)|pancreas(2)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(3)	72		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		GGCAAAGGCCCTCTCTGCTCT	0.577000								Other conserved DNA damage response genes					8	45					0.0381472	0.0383987	1	1	0
PCDHA1	56147	broad.mit.edu	37	5	140168060	140168060	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr5:140168060G>A	ENST00000504120.2	+	1	2185	c.2185G>A	c.(2185-2187)Gag>Aag	p.E729K	PCDHA1_ENST00000378133.3_Missense_Mutation_p.E729K|PCDHA1_ENST00000394633.3_Intron	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCGCCCACTGAGGGTGCGTA	0.642000													8	31					0	0	1	0	0
SEC23IP	11196	broad.mit.edu	37	10	121652440	121652440	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr10:121652440C>T	ENST00000369075.3	+	1	218	c.146C>T	c.(145-147)tCc>tTc	p.S49F	SEC23IP_ENST00000543134.1_Missense_Mutation_p.P16S	NM_007190.3	NP_009121.1	Q9Y6Y8	S23IP_HUMAN	SEC23 interacting protein	49	Interaction with SEC23A.				Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|stomach(3)|urinary_tract(1)	36		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		TCTCCGGCCTCCCTGCTCTTA	0.607000													23	39					0	0	1	0	0
RABGAP1L	9910	broad.mit.edu	37	1	174274199	174274199	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:174274199G>C	ENST00000251507.4	+	11	1573	c.1399G>C	c.(1399-1401)Gag>Cag	p.E467Q	RABGAP1L_ENST00000357444.6_Missense_Mutation_p.E430Q|RABGAP1L_ENST00000367689.3_Missense_Mutation_p.E114Q	NM_014857.4	NP_055672.3	Q5R372	RBG1L_HUMAN	RAB GTPase activating protein 1-like	467					regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			NS(1)|breast(2)|endometrium(4)|kidney(5)|large_intestine(7)|lung(21)|ovary(2)|prostate(1)|skin(2)	45						GTCTGACAAGGAGGAACCAGT	0.448000													5	53					0	0	1	0	0
SLC2A2	6514	broad.mit.edu	37	3	170723209	170723209	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:170723209C>G	ENST00000314251.3	-	7	907	c.828G>C	c.(826-828)atG>atC	p.M276I	SLC2A2_ENST00000382808.4_Missense_Mutation_p.M157I	NM_000340.1	NP_000331.1	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 2	276					carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			TTTCTTTTCTCATTTCATTAA	0.398000													34	29					0	0	1	0	0
PCBP4	57060	broad.mit.edu	37	3	51993935	51993935	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:51993935G>A	ENST00000461554.1	-	8	823	c.492C>T	c.(490-492)cgC>cgT	p.R164R	PCBP4_ENST00000484633.1_Intron|PCBP4_ENST00000428823.2_Intron|PCBP4_ENST00000395013.3_Intron|PCBP4_ENST00000395014.2_Silent_p.R185R|PCBP4_ENST00000355852.2_Silent_p.R164R|PCBP4_ENST00000322099.7_Silent_p.R164R|PCBP4_ENST00000471622.1_Silent_p.R164R	NM_001174100.1	NP_001167571.1	P57723	PCBP4_HUMAN	poly(rC) binding protein 4	164						cytoplasm|ribonucleoprotein complex	DNA binding|RNA binding			endometrium(2)|large_intestine(2)|lung(2)|prostate(1)|stomach(1)	8				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CGCAGATCTGGCGCACACACA	0.642000													14	63					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33586603	33586603	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr20:33586603G>A	ENST00000262873.7	+	33	4293	c.4201G>A	c.(4201-4203)Gag>Aag	p.E1401K		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	1359						membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			GGAGGAGGCTGAGGCCCAGGC	0.662000													4	9					0	0	1	0	0
SLC45A1	50651	broad.mit.edu	37	1	8390570	8390570	+	Silent	SNP	G	G	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:8390570G>T	ENST00000471889.1	+	5	1402	c.1017G>T	c.(1015-1017)tcG>tcT	p.S339S	SLC45A1_ENST00000377479.2_Silent_p.S373S|SLC45A1_ENST00000289877.8_Silent_p.S339S|SLC45A1_ENST00000481265.1_3'UTR			Q9Y2W3	S45A1_HUMAN	solute carrier family 45, member 1	339					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(2)	33	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GCCCCATCTCGCCGCCCAGCC	0.687000													6	21					0.217242	0.217718	1	1	0
CACNA1S	779	broad.mit.edu	37	1	201079382	201079382	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:201079382G>A	ENST00000362061.3	-	2	394	c.168C>T	c.(166-168)atC>atT	p.I56I	CACNA1S_ENST00000367338.3_Silent_p.I56I	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	56					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TGAGCAAGATGATCGTCTCGA	0.572000													6	49					0	0	1	0	0
PDXDC2P	283970	broad.mit.edu	37	16	70012163	70012163	+	RNA	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr16:70012163C>G	ENST00000531894.1	-	0	2519				RP11-419C5.2_ENST00000525562.1_RNA	NR_003610.1																						CACCGCAACTCTTGCGCACGT	0.458000													83	101					0	0	1	0	0
PPP1R8	5511	broad.mit.edu	37	1	28165350	28165350	+	Silent	SNP	A	A	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:28165350A>C	ENST00000311772.5	+	3	316	c.258A>C	c.(256-258)atA>atC	p.I86I	PPP1R8_ENST00000236412.7_5'UTR|PPP1R8_ENST00000373931.4_5'UTR	NM_014110.4	NP_054829.2	Q12972	PP1R8_HUMAN	protein phosphatase 1, regulatory subunit 8	86	FHA.|Interaction with CDC5L, SF3B1 and MELK.				mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|RNA splicing|transcription, DNA-dependent	cytoplasm|nuclear speck|spliceosomal complex	DNA binding|endonuclease activity|protein binding|protein serine/threonine phosphatase inhibitor activity|ribonuclease E activity|RNA binding			breast(2)|cervix(1)|endometrium(2)|lung(2)|upper_aerodigestive_tract(1)	8		Colorectal(325;3.46e-05)|all_lung(284;0.000129)|Lung NSC(340;0.000259)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;2.76e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00248)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)		TTTTCCTGATAGATCTCAACA	0.403000													15	33					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51523771	51523771	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:51523771G>A	ENST00000371117.3	-	61	11428	c.11153C>T	c.(11152-11154)tCa>tTa	p.S3718L		NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	3718					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					GACTCCCTTTGACTGAGTAAC	0.388000													37	98					0	0	1	0	0
PLEKHG6	55200	broad.mit.edu	37	12	6436424	6436424	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:6436424C>T	ENST00000449001.2	+	14	2073	c.1579C>T	c.(1579-1581)Cct>Tct	p.P527S	PLEKHG6_ENST00000396988.3_Missense_Mutation_p.P559S|PLEKHG6_ENST00000304581.8_Missense_Mutation_p.P89S|PLEKHG6_ENST00000011684.7_Missense_Mutation_p.P559S	NM_001144857.1	NP_001138329.1	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	559					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(4)	23						CTGTAGGACTCCTGAGTTCTC	0.517000											OREG0021622	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	60					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13346484	13346484	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:13346484G>A	ENST00000360228.5	-	32	5010	c.5011C>T	c.(5011-5013)Ctc>Ttc	p.L1671F	CACNA1A_ENST00000574822.1_5'UTR|CACNA1A_ENST00000573710.2_Missense_Mutation_p.L1672F	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1672					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CCCTGACGGAGAAGTTTGATG	0.572000											OREG0025293	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	49					0	0	1	0	0
WSCD2	9671	broad.mit.edu	37	12	108626600	108626600	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:108626600C>T	ENST00000332082.4	+	8	1890	c.1072C>T	c.(1072-1074)Cgc>Tgc	p.R358C	WSCD2_ENST00000261400.3_Missense_Mutation_p.R358C|WSCD2_ENST00000549903.1_Missense_Mutation_p.R358C|WSCD2_ENST00000547525.1_Missense_Mutation_p.R358C			Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	358						integral to membrane				breast(4)|endometrium(3)|kidney(1)|large_intestine(16)|liver(2)|lung(23)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	57						CACGTGGGCTCGCCACCTCAT	0.562000													15	26					0	0	1	0	0
POLR2E	5434	broad.mit.edu	37	19	1090945	1090945	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:1090945G>A	ENST00000215587.7	-	4	674	c.391C>T	c.(391-393)Ctg>Ttg	p.L131L	POLR2E_ENST00000586746.1_Silent_p.L131L|POLR2E_ENST00000585838.1_5'UTR			P19388	RPAB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide E, 25kDa	131					interspecies interaction between organisms|mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|skin(2)	11		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCTGCTGCAGAAACTGCTCC	0.657000													7	35					0	0	1	0	0
ZNF83	55769	broad.mit.edu	37	19	53116885	53116885	+	Silent	SNP	A	A	G	rs7247257		TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:53116885A>G	ENST00000597597.1	-	2	3186	c.933T>C	c.(931-933)caT>caC	p.H311H	ZNF83_ENST00000544146.1_Silent_p.H311H|ZNF83_ENST00000600714.1_Intron|ZNF83_ENST00000594682.2_3'UTR|ZNF83_ENST00000541777.2_Silent_p.H311H|ZNF83_ENST00000601257.1_Intron|ZNF83_ENST00000545872.1_Silent_p.H311H|ZNF83_ENST00000536937.1_Silent_p.H311H|ZNF83_ENST00000301096.3_Silent_p.H311H|ZNF83_ENST00000391789.4_Silent_p.H283H			P51522	ZNF83_HUMAN	zinc finger protein 83	311						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	18				OV - Ovarian serous cystadenocarcinoma(262;0.00841)|GBM - Glioblastoma multiforme(134;0.0244)		TCTCTCCAGTATGAATTCTCC	0.418000													4	210					0	0	1	0	0
SYCP2	10388	broad.mit.edu	37	20	58468607	58468607	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr20:58468607C>G	ENST00000357552.3	-	21	1932	c.1707G>C	c.(1705-1707)aaG>aaC	p.K569N	SYCP2_ENST00000371001.2_Missense_Mutation_p.K569N			Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	569					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			ATTCAACATTCTTATTTTCTG	0.284000													5	50					0	0	1	0	0
SEC31B	25956	broad.mit.edu	37	10	102248677	102248677	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr10:102248677G>A	ENST00000370345.3	-	24	3323	c.3226C>T	c.(3226-3228)Cag>Tag	p.Q1076*		NM_015490.3	NP_056305.1	Q9NQW1	SC31B_HUMAN	SEC31 homolog B (S. cerevisiae)	1076					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				NS(1)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(3)|lung(17)|ovary(1)|urinary_tract(1)	36		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		TTCAAGGACTGATGCTCTGGG	0.557000													4	51					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176845725	176845725	+	Silent	SNP	G	G	A	rs143931548	byFrequency	TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:176845725G>A	ENST00000367654.3	-	21	3646	c.3435C>T	c.(3433-3435)agC>agT	p.S1145S	ASTN1_ENST00000361833.2_Silent_p.S1137S|ASTN1_ENST00000424564.2_Silent_p.S1137S|ASTN1_ENST00000367657.3_Silent_p.S1137S	NM_004319.1	NP_004310.1	O14525	ASTN1_HUMAN	astrotactin 1		Fibronectin type-III 1.				cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						CGATCACGTCGCTTGGCCTGG	0.577000													8	31					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196728982	196728982	+	Missense_Mutation	SNP	C	C	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr2:196728982C>A	ENST00000312428.6	-	41	7497	c.7397G>T	c.(7396-7398)cGc>cTc	p.R2466L		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2466	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						CAGTTGGCTGCGGCAATGATC	0.463000													24	52					9.57634e-11	1.02476e-10	1	1	0
TSEN54	283989	broad.mit.edu	37	17	73519387	73519387	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr17:73519387G>C	ENST00000333213.6	+	9	1320	c.1284G>C	c.(1282-1284)caG>caC	p.Q428H		NM_207346.2	NP_997229.2	Q7Z6J9	SEN54_HUMAN	TSEN54 tRNA splicing endonuclease subunit	428					mRNA processing|tRNA splicing, via endonucleolytic cleavage and ligation	nucleolus				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(5)|ovary(2)	13	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CTGTGCTGCAGACAACACACC	0.532000													32	112					0	0	1	0	0
TRPV4	59341	broad.mit.edu	37	12	110252501	110252501	+	Missense_Mutation	SNP	G	G	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:110252501G>T	ENST00000418703.2	-	1	195	c.101C>A	c.(100-102)tCc>tAc	p.S34Y	TRPV4_ENST00000544971.1_Missense_Mutation_p.S34Y|TRPV4_ENST00000261740.2_Missense_Mutation_p.S34Y|TRPV4_ENST00000537083.1_Missense_Mutation_p.S34Y|TRPV4_ENST00000536838.1_Intron|TRPV4_ENST00000346520.2_Missense_Mutation_p.S34Y|TRPV4_ENST00000541794.1_Missense_Mutation_p.S34Y|TRPV4_ENST00000392719.2_Missense_Mutation_p.S34Y	NM_001177431.1	NP_001170902.1	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel, subfamily V, member 4	34					actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(2)|skin(4)|stomach(1)	35						GGCCAGGGAGGAGAGAGGAAA	0.682000													8	5					0.000157383	0.000161256	1	1	0
KCNC3	3748	broad.mit.edu	37	19	50831808	50831808	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:50831808C>A	ENST00000376959.2	-	1	695	c.532G>T	c.(532-534)Gag>Tag	p.E178*	KCNC3_ENST00000474951.1_Intron|KCNC3_ENST00000477616.1_Nonsense_Mutation_p.E178*|KCNC3_ENST00000391818.2_Intron			Q14003	KCNC3_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 3	178					cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(2)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)	13		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		ACGTCGGTCTCGTCGATGCCC	0.697000													7	32					0.00448238	0.00454188	1	1	0
SETX	23064	broad.mit.edu	37	9	135224725	135224725	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr9:135224725G>A	ENST00000372169.2	-	3	273	c.91C>T	c.(91-93)Caa>Taa	p.Q31*	SETX_ENST00000224140.5_Nonsense_Mutation_p.Q31*|SETX_ENST00000393220.1_Nonsense_Mutation_p.Q31*			Q7Z333	SETX_HUMAN	senataxin	31					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TCGGCTGTTTGAAATTCACCG	0.468000													4	62					0	0	1	0	0
LRRFIP2	9209	broad.mit.edu	37	3	37149616	37149616	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:37149616G>C	ENST00000421307.1	-	14	1084	c.662C>G	c.(661-663)tCt>tGt	p.S221C	LRRFIP2_ENST00000354379.4_Intron|LRRFIP2_ENST00000336686.4_Missense_Mutation_p.S221C|LRRFIP2_ENST00000440230.1_Intron|LRRFIP2_ENST00000396428.2_Intron|LRRFIP2_ENST00000421276.2_Intron	NM_006309.2	NP_006300.1	Q9Y608	LRRF2_HUMAN	leucine rich repeat (in FLII) interacting protein 2	221	DVL3-binding.|Ser-rich.				Wnt receptor signaling pathway		LRR domain binding	p.0?(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22						ACTGCATTCAGATGGCTATAA	0.388000													6	40					0	0	1	0	0
LRIG3	121227	broad.mit.edu	37	12	59267942	59267942	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:59267942G>C	ENST00000320743.3	-	18	3296	c.3010C>G	c.(3010-3012)Cac>Gac	p.H1004D	LRIG3_ENST00000379141.4_Missense_Mutation_p.H944D	NM_153377.4	NP_700356.2	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like domains 3	1004						integral to membrane			LRIG3/ROS1(2)	breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(12)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48			GBM - Glioblastoma multiforme(1;1.17e-18)			CCTTCATTGTGAGAGTAACTA	0.428000			T	ROS1	NSCLC								51	69					0	0	1	0	0
MRGPRX3	117195	broad.mit.edu	37	11	18159610	18159610	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:18159610G>A	ENST00000396275.2	+	3	1222	c.861G>A	c.(859-861)ctG>ctA	p.L287L		NM_054031.3	NP_473372.3	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	287						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						GGCAGAACCTGAAGCTGGTTC	0.537000													30	41					0	0	1	0	0
KIFC1	3833	broad.mit.edu	37	6	33372957	33372957	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:33372957G>C	ENST00000428849.2	+	7	1535	c.1085G>C	c.(1084-1086)gGg>gCg	p.G362A		NM_002263.3	NP_002254.2	Q9BW19	KIFC1_HUMAN	kinesin family member C1	362	Kinesin-motor.				blood coagulation|cell division|microtubule-based movement|mitotic sister chromatid segregation	early endosome|microtubule|microtubule associated complex|microtubule organizing center|nucleus|spindle	ATP binding|microtubule motor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(3)|skin(1)	13						ACCCTGAGTGGGGCACCAGCT	0.602000													16	109					0	0	1	0	0
PRAMEF10	343071	broad.mit.edu	37	1	12955520	12955520	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:12955520C>T	ENST00000235347.4	-	2	238	c.159G>A	c.(157-159)aaG>aaA	p.K53K		NM_001039361.3	NP_001034450.2	O60809	PRA10_HUMAN	PRAME family member 10	53										NS(2)|breast(1)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	12	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GCACCATCAGCTTCAGGGCCT	0.557000													14	11					0	0	1	0	0
RUSC1	23623	broad.mit.edu	37	1	155294665	155294665	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:155294665C>T	ENST00000368352.5	+	3	1538	c.1387C>T	c.(1387-1389)Ccc>Tcc	p.P463S	RUSC1_ENST00000292254.4_5'UTR|RUSC1_ENST00000462780.1_3'UTR|RUSC1_ENST00000368354.3_Missense_Mutation_p.P463S|RUSC1_ENST00000368349.4_5'UTR|RUSC1_ENST00000368347.4_Missense_Mutation_p.P53S	NM_001105203.1	NP_001098673.1	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1	463						cytoplasm|nucleolus	SH3/SH2 adaptor activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(2)|skin(1)|urinary_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			CGCCGGTGTCCCCGGAGCCCA	0.627000													55	158					0	0	1	0	0
HMOX2	3163	broad.mit.edu	37	16	4557745	4557745	+	Nonsense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr16:4557745C>G	ENST00000570646.1	+	4	841	c.236C>G	c.(235-237)tCa>tGa	p.S79*	HMOX2_ENST00000458134.3_Nonsense_Mutation_p.S79*|HMOX2_ENST00000406590.2_Nonsense_Mutation_p.S79*|HMOX2_ENST00000219700.6_Nonsense_Mutation_p.S79*|HMOX2_ENST00000575120.1_Nonsense_Mutation_p.S50*|HMOX2_ENST00000398595.3_Nonsense_Mutation_p.S79*|HMOX2_ENST00000414777.1_Nonsense_Mutation_p.S79*	NM_002134.3	NP_002125.3	P30519	HMOX2_HUMAN	heme oxygenase (decycling) 2	79					cellular iron ion homeostasis|heme catabolic process|heme oxidation|response to hypoxia|transmembrane transport	endoplasmic reticulum membrane|microsome|plasma membrane	electron carrier activity|heme oxygenase (decyclizing) activity|metal ion binding|protein binding			endometrium(1)|large_intestine(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	8					NADH(DB00157)	TTCACATACTCAGCCCTCGAG	0.597000													16	12					0	0	1	0	0
MAPK10	5602	broad.mit.edu	37	4	86950420	86950420	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr4:86950420G>C	ENST00000395169.3	-	13	1788	c.1068C>G	c.(1066-1068)atC>atG	p.I356M	MAPK10_ENST00000359221.3_Missense_Mutation_p.I394M|MAPK10_ENST00000449047.2_Missense_Mutation_p.I249M|MAPK10_ENST00000395161.2_Missense_Mutation_p.I394M|MAPK10_ENST00000361569.2_Missense_Mutation_p.I394M|MAPK10_ENST00000395166.1_Missense_Mutation_p.I356M|MAPK10_ENST00000395157.3_Missense_Mutation_p.I249M|MAPK10_ENST00000395160.3_Missense_Mutation_p.I249M	NM_138980.2|NM_138982.2	NP_620446.1|NP_620448.1	P53779	MK10_HUMAN	mitogen-activated protein kinase 10	394	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|MAP kinase kinase activity|protein binding			breast(1)|central_nervous_system(1)|stomach(1)	3		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.243)		OV - Ovarian serous cystadenocarcinoma(123;0.002)		CTTCCTTGTAGATAAGTTCTG	0.333000													11	34					0	0	1	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92706050	92706050	+	Silent	SNP	G	G	T	rs144388319	byFrequency	TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr15:92706050G>T	ENST00000318445.6	+	10	2032	c.1818G>T	c.(1816-1818)acG>acT	p.T606T	RP11-24J19.1_ENST00000557683.1_RNA|SLCO3A1_ENST00000424469.2_Silent_p.T606T|RP11-152L20.3_ENST00000561674.1_RNA|SLCO3A1_ENST00000555549.1_3'UTR	NM_013272.3	NP_037404.2	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family, member 3A1	606					sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	25	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			TCTGGAGCACGTTCTGTGGGG	0.557000													22	50					1.50039e-11	1.6131e-11	1	1	0
IPP	3652	broad.mit.edu	37	1	46206708	46206708	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:46206708C>T	ENST00000396478.3	-	3	691	c.589G>A	c.(589-591)Gaa>Aaa	p.E197K		NM_005897.2	NP_005888.1	Q9Y573	IPP_HUMAN	intracisternal A particle-promoted polypeptide	197						actin cytoskeleton|cytoplasm	actin binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|stomach(2)	20	Acute lymphoblastic leukemia(166;0.155)					ACCTGGTATTCATCCTCAATG	0.413000													40	86					0	0	1	0	0
GATAD2A	54815	broad.mit.edu	37	19	19609398	19609398	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:19609398G>A	ENST00000404158.1	+	10	1489	c.1071G>A	c.(1069-1071)gaG>gaA	p.E357E	GATAD2A_ENST00000537887.1_5'UTR|GATAD2A_ENST00000429563.2_Silent_p.E184E|GATAD2A_ENST00000252577.5_Silent_p.E357E|GATAD2A_ENST00000358713.3_Silent_p.E357E|GATAD2A_ENST00000360315.3_Silent_p.E357E			Q86YP4	P66A_HUMAN	GATA zinc finger domain containing 2A	357					DNA methylation|negative regulation of transcription, DNA-dependent	nuclear speck|NuRD complex	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	13						AACAGCTGGAGAAGACGCTAC	0.647000													8	28					0	0	1	0	0
KRT40	125115	broad.mit.edu	37	17	39135172	39135172	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr17:39135172C>T	ENST00000377755.4	-	6	1114	c.1080G>A	c.(1078-1080)gaG>gaA	p.E360E	KRT40_ENST00000398486.2_Silent_p.E360E			Q6A162	K1C40_HUMAN	keratin 40	360	Coil 2.|Rod.					intermediate filament	structural molecule activity			endometrium(1)|large_intestine(2)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	9		Breast(137;0.00043)				CGCAGCGGATCTCGGCCAGCT	0.602000													172	104					0	0	1	0	0
C2CD5	9847	broad.mit.edu	37	12	22671062	22671062	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:22671062G>A	ENST00000333957.4	-	8	1065	c.810C>T	c.(808-810)ttC>ttT	p.F270F	C2CD5_ENST00000544930.1_Intron|C2CD5_ENST00000536386.1_Intron|C2CD5_ENST00000545552.1_Intron|C2CD5_ENST00000446597.1_Silent_p.F270F|C2CD5_ENST00000540703.1_5'UTR|C2CD5_ENST00000542676.1_Silent_p.F270F|C2CD5_ENST00000396028.2_Intron	NM_014802.1	NP_055617.1			C2 calcium-dependent domain containing 5									p.F270F(1)									GATCTTCATTGAAGGGAATCC	0.448000													41	63					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143016946	143016946	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr7:143016946G>A	ENST00000343257.2	+	2	366	c.279G>A	c.(277-279)gaG>gaA	p.E93E		NM_000083.2	NP_000074	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	93					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					GCAAGGATGAGGATCACTATT	0.453000													26	66					0	0	1	0	0
KIFAP3	22920	broad.mit.edu	37	1	170003630	170003630	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:170003630G>C	ENST00000367765.1	-	7	2006	c.505C>G	c.(505-507)Caa>Gaa	p.Q169E	KIFAP3_ENST00000367767.1_Missense_Mutation_p.Q165E|KIFAP3_ENST00000538366.1_Missense_Mutation_p.Q131E|KIFAP3_ENST00000361580.2_Missense_Mutation_p.Q209E	NM_001204517.1	NP_001191446.1	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	209					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(18)|prostate(2)|skin(3)|urinary_tract(2)	35	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CCATGAAATTGAGAAAAGCTT	0.303000													6	33					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144873974	144873974	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:144873974G>A	ENST00000369359.4	-	34	5429	c.5391C>T	c.(5389-5391)acC>acT	p.T1797T	PDE4DIP_ENST00000369356.4_Silent_p.T1661T|PDE4DIP_ENST00000313382.9_Silent_p.T1617T|PDE4DIP_ENST00000530740.1_Intron|PDE4DIP_ENST00000369354.3_Silent_p.T1661T|PDE4DIP_ENST00000524974.1_5'UTR			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1661					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GAGATGCACTGGTTGATGATG	0.473000			T	PDGFRB	MPD								23	434					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27556683	27556683	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr16:27556683C>T	ENST00000356183.4	-	2	398	c.383G>A	c.(382-384)aGa>aAa	p.R128K	GTF3C1_ENST00000561623.1_Missense_Mutation_p.R128K	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	128						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						GGACTTGGTTCTGATGTCATT	0.473000													29	257					0	0	1	0	0
YTHDF2	51441	broad.mit.edu	37	1	29069664	29069664	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:29069664G>C	ENST00000373812.3	+	4	1244	c.882G>C	c.(880-882)caG>caC	p.Q294H	YTHDF2_ENST00000478283.1_3'UTR|YTHDF2_ENST00000541996.1_Missense_Mutation_p.Q244H|YTHDF2_ENST00000542507.1_Missense_Mutation_p.Q294H	NM_016258.2	NP_057342.2	Q9Y5A9	YTHD2_HUMAN	YTH domain family, member 2	294					humoral immune response					NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Colorectal(325;3.46e-05)|Lung NSC(340;0.000601)|all_lung(284;0.000771)|Breast(348;0.00502)|Renal(390;0.00758)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;5.46e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		CTTTGGTTCAGAATATAGGTC	0.537000													23	24					0	0	1	0	0
TMEM214	54867	broad.mit.edu	37	2	27259456	27259456	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr2:27259456G>A	ENST00000238788.9	+	6	884	c.822G>A	c.(820-822)ctG>ctA	p.L274L	TMEM214_ENST00000404032.3_Silent_p.L229L	NM_017727.4	NP_060197.4	Q6NUQ4	TM214_HUMAN	transmembrane protein 214	274						integral to membrane	protein binding			kidney(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						CCGAGGGACTGAAAGGTAACA	0.572000													17	54					0	0	1	0	0
CABP5	56344	broad.mit.edu	37	19	48537545	48537545	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:48537545C>T	ENST00000293255.2	-	5	553	c.423G>A	c.(421-423)cgG>cgA	p.R141R		NM_019855.4	NP_062829.1	Q9NP86	CABP5_HUMAN	calcium binding protein 5	141					signal transduction	cytoplasm	calcium ion binding			endometrium(1)|large_intestine(3)|lung(3)|prostate(2)|skin(2)	11		all_cancers(25;1.86e-08)|all_lung(116;1.14e-06)|all_epithelial(76;1.16e-06)|Lung NSC(112;2.54e-06)|all_neural(266;0.0138)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;4.09e-05)|all cancers(93;0.000322)|Epithelial(262;0.01)|GBM - Glioblastoma multiforme(486;0.058)		GGGGGGTGAGCCGCTCCCCCA	0.552000													18	33					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117804556	117804556	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr9:117804556C>T	ENST00000350763.4	-	18	5601	c.5190G>A	c.(5188-5190)tgG>tgA	p.W1730*	TNC_ENST00000346706.3_Nonsense_Mutation_p.W1184*|TNC_ENST00000345230.3_Nonsense_Mutation_p.W1093*|TNC_ENST00000542877.1_Nonsense_Mutation_p.W1367*|TNC_ENST00000535648.1_Nonsense_Mutation_p.W1275*|TNC_ENST00000537320.1_Nonsense_Mutation_p.W1093*|TNC_ENST00000423613.2_Nonsense_Mutation_p.W1457*|TNC_ENST00000340094.3_Nonsense_Mutation_p.W1366*|TNC_ENST00000341037.4_Nonsense_Mutation_p.W1548*	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	1730	Fibronectin type-III 13.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						TGGGTGCCCTCCAGCTGACAG	0.522000													35	27					0	0	1	0	0
ETV6	2120	broad.mit.edu	37	12	11992232	11992232	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:11992232C>T	ENST00000396373.4	+	3	596	c.322C>T	c.(322-324)Cat>Tat	p.H108Y		NM_001987.4	NP_001978.1	P41212	ETV6_HUMAN	ets variant 6	108	PNT.					cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.Y104fs*14(1)	ETV6/JAK2(11)|ETV6/ITPR2(2)|ETV6/NTRK3(238)	breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(15)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				TCGATCTCCTCATTCAGGTGA	0.463000			T	"""NTRK3, RUNX1, PDGFRB, ABL1, MN1, ABL2, FACL6, CHIC2, ARNT, JAK2, EVI1, CDX2, STL, HLXB9, MDS2, PER1, SYK, TTL, FGFR3, PAX5"""	"""congenital fibrosarcoma, multiple leukemia and lymphoma,  secretory breast, MDS, ALL"""								28	33					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170011071	170011071	+	Missense_Mutation	SNP	C	C	G	rs147817392		TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr2:170011071C>G	ENST00000263816.3	-	66	12479	c.12194G>C	c.(12193-12195)cGa>cCa	p.R4065P		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	4065					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ATTATATTTTCGAATTCGGAC	0.378000													24	65					0	0	1	0	0
USP47	55031	broad.mit.edu	37	11	11924854	11924854	+	Translation_Start_Site	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:11924854G>A	ENST00000539466.1	+	0	995				USP47_ENST00000527733.1_Missense_Mutation_p.D262N|USP47_ENST00000339865.5_Missense_Mutation_p.D194N|USP47_ENST00000399455.2_Missense_Mutation_p.D282N			Q96K76	UBP47_HUMAN	ubiquitin specific peptidase 47						base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			breast(4)|endometrium(7)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46				Epithelial(150;0.000339)		AGTCATGTTTGATGCTTTGGA	0.328000													30	34					0	0	1	0	0
MFSD1	64747	broad.mit.edu	37	3	158539890	158539890	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:158539890G>A	ENST00000415822.2	+	11	1326	c.1185G>A	c.(1183-1185)atG>atA	p.M395I	MFSD1_ENST00000392813.4_Missense_Mutation_p.M356I|MFSD1_ENST00000264266.8_Missense_Mutation_p.M346I	NM_022736.2	NP_073573.2	Q9H3U5	MFSD1_HUMAN	major facilitator superfamily domain containing 1	346					transmembrane transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(15)|skin(1)	26			Lung(72;0.00372)|LUSC - Lung squamous cell carcinoma(72;0.00523)			TGTCCCACATGATGCTGGCCT	0.527000													11	50					0	0	1	0	0
GUCD1	83606	broad.mit.edu	37	22	24939921	24939921	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr22:24939921C>T	ENST00000435822.1	-	5	841	c.517G>A	c.(517-519)Ggc>Agc	p.G173S	GUCD1_ENST00000407471.3_Missense_Mutation_p.G173S|GUCD1_ENST00000447813.2_Intron|GUCD1_ENST00000490922.1_Intron|GUCD1_ENST00000404664.3_Missense_Mutation_p.G229S|GUCD1_ENST00000402766.1_Intron	NM_001284252.1|NM_001284254.1|NM_031444.2	NP_001271181.1|NP_001271183.1|NP_113632.2			guanylyl cyclase domain containing 1																		CAGTGGTGGCCACTGGGGGTG	0.622000													4	6					0	0	1	0	0
CCNG2	901	broad.mit.edu	37	4	78079786	78079786	+	Missense_Mutation	SNP	G	G	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr4:78079786G>T	ENST00000316355.5	+	2	457	c.101G>T	c.(100-102)cGa>cTa	p.R34L	CCNG2_ENST00000509972.1_Missense_Mutation_p.R34L|CCNG2_ENST00000497512.1_3'UTR|CCNG2_ENST00000395640.1_Missense_Mutation_p.R34L|CCNG2_ENST00000354403.5_Missense_Mutation_p.R34L|CCNG2_ENST00000502280.1_Missense_Mutation_p.R34L	NM_004354.2	NP_004345.1	Q16589	CCNG2_HUMAN	cyclin G2	34					cell cycle checkpoint|cell division|mitosis	cytoplasm				breast(1)|kidney(2)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	10						TTCCAACCTCGAGAAAAAGGG	0.517000													10	29					0.00010058	0.000103286	1	1	0
DENND4B	9909	broad.mit.edu	37	1	153905988	153905988	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:153905988G>A	ENST00000361217.4	-	20	3719	c.3301C>T	c.(3301-3303)Cgg>Tgg	p.R1101W		NM_014856.2	NP_055671.2	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	1101										NS(1)|breast(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	36	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GGGCGCTCCCGGGGGTGCAGA	0.662000													7	20					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10467923	10467923	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr8:10467923C>T	ENST00000382483.3	-	4	3908	c.3685G>A	c.(3685-3687)Gag>Aag	p.E1229K		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1229					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		AGGGGCAGCTCTGTCCCCTGT	0.567000													8	18					0	0	1	0	0
RPL23	9349	broad.mit.edu	37	17	37006675	37006675	+	Missense_Mutation	SNP	C	C	G	rs139318203	byFrequency	TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr17:37006675C>G	ENST00000479035.2	-	4	412	c.280G>C	c.(280-282)Gtg>Ctg	p.V94L	RPL23_ENST00000394332.1_Missense_Mutation_p.V94L|RPL23_ENST00000394333.1_Intron|RPL23_ENST00000245857.5_Missense_Mutation_p.V35L|RPL23_ENST00000577407.1_Missense_Mutation_p.V94L	NM_000978.3	NP_000969.1	P62829	RL23_HUMAN	ribosomal protein L23	94					endocrine pancreas development|ribosomal protein import into nucleus|translational elongation|translational termination|viral transcription	cytosol|ribosome	protein binding|structural constituent of ribosome			endometrium(2)|large_intestine(1)	3						TAAAGAAACACGCCATCTTTT	0.423000													5	145					0	0	1	0	0
CCDC54	84692	broad.mit.edu	37	3	107097009	107097009	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:107097009C>T	ENST00000261058.1	+	1	822	c.575C>T	c.(574-576)tCa>tTa	p.S192L		NM_032600.2	NP_115989.1	Q8NEL0	CCD54_HUMAN	coiled-coil domain containing 54	192										NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	19						GAAATCTCTTCAGCAGAACCA	0.413000													18	85					0	0	1	0	0
LZTS2	84445	broad.mit.edu	37	10	102765246	102765246	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr10:102765246G>C	ENST00000370220.1	+	3	4163	c.1100G>C	c.(1099-1101)cGa>cCa	p.R367P	LZTS2_ENST00000370223.3_Missense_Mutation_p.R367P			Q9BRK4	LZTS2_HUMAN	leucine zipper, putative tumor suppressor 2	367					cell division|mitosis|Wnt receptor signaling pathway	membrane|microtubule|microtubule organizing center				breast(1)|large_intestine(6)|lung(7)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22				Epithelial(162;7.3e-09)|all cancers(201;3.72e-07)		CACTGGCAGCGAGAGCGTGAG	0.667000													4	33					0	0	1	0	0
GBX2	2637	broad.mit.edu	37	2	237074994	237074994	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr2:237074994C>T	ENST00000306318.4	-	2	1007	c.610G>A	c.(610-612)Gat>Aat	p.D204N	GBX2_ENST00000551105.1_Missense_Mutation_p.R216Q|GBX2_ENST00000465889.1_5'UTR	NM_001485.2	NP_001476.2	P52951	GBX2_HUMAN	gastrulation brain homeobox 2	204						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)	7		Breast(86;0.00235)|Renal(207;0.00339)|all_hematologic(139;0.00357)|all_lung(227;0.0616)|Acute lymphoblastic leukemia(138;0.0775)|Ovarian(221;0.089)|Lung NSC(271;0.179)		Epithelial(121;4.5e-25)|OV - Ovarian serous cystadenocarcinoma(60;5.16e-11)|BRCA - Breast invasive adenocarcinoma(100;3.4e-05)|Lung(119;0.00195)|LUSC - Lung squamous cell carcinoma(224;0.00471)		TAGTCCACATCGCTCTCCAGC	0.627000													35	38					0	0	1	0	0
TNK2	10188	broad.mit.edu	37	3	195594568	195594568	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:195594568C>G	ENST00000333602.6	-	12	3173	c.2556G>C	c.(2554-2556)aaG>aaC	p.K852N	TNK2_ENST00000381916.2_Missense_Mutation_p.K930N|TNK2_ENST00000428187.1_Missense_Mutation_p.K884N|TNK2_ENST00000392400.1_Missense_Mutation_p.K852N	NM_005781.4	NP_005772.3	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2	852	EBD domain (By similarity).|Pro-rich.			Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(11)|ovary(3)|prostate(4)|skin(2)|stomach(1)|urinary_tract(1)	29	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	TGCTGACCTTCTTGCCATCCC	0.657000													12	11					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84454944	84454944	+	Silent	SNP	A	A	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr13:84454944A>G	ENST00000377084.2	-	1	1584	c.699T>C	c.(697-699)aaT>aaC	p.N233N		NM_001281503.1|NM_052910.1	NP_001268432.1|NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	233	LRRCT 1.					integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CGATCAGGGCATTCTTGGGAA	0.522000													3	56					0	0	1	0	0
DES	1674	broad.mit.edu	37	2	220285561	220285561	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr2:220285561G>A	ENST00000373960.3	+	5	995	c.909G>A	c.(907-909)ctG>ctA	p.L303L		NM_001927.3	NP_001918.3	P17661	DESM_HUMAN	desmin	303	Coil 2B.|Rod.				cytoskeleton organization|muscle filament sliding|regulation of heart contraction	cytosol|Z disc	protein binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(10)|skin(1)	18		Renal(207;0.0183)		Epithelial(149;5.25e-07)|all cancers(144;0.000103)|Lung(261;0.00533)|LUSC - Lung squamous cell carcinoma(224;0.008)		TGTCAGACCTGACCCAGGCAG	0.577000													9	25					0	0	1	0	0
NEK11	79858	broad.mit.edu	37	3	130851629	130851629	+	Missense_Mutation	SNP	C	C	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:130851629C>A	ENST00000383366.4	+	6	789	c.496C>A	c.(496-498)Ctg>Atg	p.L166M	NEK11_ENST00000356918.4_Missense_Mutation_p.L166M|NEK11_ENST00000510769.1_Missense_Mutation_p.L166M|NEK11_ENST00000429253.2_Missense_Mutation_p.L166M|NEK11_ENST00000510688.1_Missense_Mutation_p.L166M|NEK11_ENST00000508196.1_Missense_Mutation_p.L166M|NEK11_ENST00000507910.1_Missense_Mutation_p.L166M|NEK11_ENST00000412440.2_Missense_Mutation_p.L18M|NEK11_ENST00000511262.1_Missense_Mutation_p.L166M|NEK11_ENST00000426022.2_3'UTR	NM_024800.4	NP_079076.3	Q8NG66	NEK11_HUMAN	NIMA-related kinase 11	166	Protein kinase.				cell cycle|intra-S DNA damage checkpoint|intracellular protein kinase cascade	nucleolus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(14)|stomach(1)|urinary_tract(2)	33						GAATGTATTTCTGAAAAATAA	0.269000													9	25					4.68919e-08	4.95993e-08	1	1	0
YTHDF2	51441	broad.mit.edu	37	1	29070088	29070088	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:29070088G>C	ENST00000373812.3	+	4	1668	c.1306G>C	c.(1306-1308)Gag>Cag	p.E436Q	YTHDF2_ENST00000478283.1_3'UTR|YTHDF2_ENST00000541996.1_Missense_Mutation_p.E386Q|YTHDF2_ENST00000542507.1_Missense_Mutation_p.E436Q	NM_016258.2	NP_057342.2	Q9Y5A9	YTHD2_HUMAN	YTH domain family, member 2	436	YTH.				humoral immune response					NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Colorectal(325;3.46e-05)|Lung NSC(340;0.000601)|all_lung(284;0.000771)|Breast(348;0.00502)|Renal(390;0.00758)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;5.46e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		GTGCAGCACAGAGCATGGTAA	0.448000													20	30					0	0	1	0	0
UTRN	7402	broad.mit.edu	37	6	144783883	144783883	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:144783883G>C	ENST00000367545.3	+	22	2947	c.2947G>C	c.(2947-2949)Gaa>Caa	p.E983Q		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	983					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TCCTGATGTAGAAAAATTATA	0.363000													22	37					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51392445	51392445	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:51392445G>A	ENST00000266037.9	+	41	4263	c.4240G>A	c.(4240-4242)Gat>Aat	p.D1414N		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1414	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CCTACAGTGCGATGCCCAGTG	0.607000													13	15					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62287779	62287779	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:62287779G>C	ENST00000378024.4	-	5	14384	c.14110C>G	c.(14110-14112)Cta>Gta	p.L4704V	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	4704					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				GGGCCCTTTAGTTTCGCATCT	0.483000													153	138					0	0	1	0	0
C12orf4	57102	broad.mit.edu	37	12	4643426	4643426	+	Missense_Mutation	SNP	A	A	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:4643426A>C	ENST00000261250.3	-	3	308	c.221T>G	c.(220-222)cTc>cGc	p.L74R	C12orf4_ENST00000545746.1_Missense_Mutation_p.L74R	NM_020374.2	NP_065107.1	Q9NQ89	CL004_HUMAN	chromosome 12 open reading frame 4	74										NS(1)|endometrium(1)|large_intestine(6)|lung(4)|upper_aerodigestive_tract(1)	13			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)	BRCA - Breast invasive adenocarcinoma(232;0.0281)		ATAATCGCTGAGGGATTCTTC	0.428000													12	57					0	0	1	0	0
TBX10	347853	broad.mit.edu	37	11	67401659	67401659	+	Splice_Site	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:67401659C>T	ENST00000335385.3	-	4	637		c.e4+1			NM_005995.4	NP_005986.2	O75333	TBX10_HUMAN	T-box 10						anatomical structure morphogenesis|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.?(1)		endometrium(2)|lung(4)|ovary(1)	7						CCCGGCCTCACGTGGCCATTG	0.637000													27	67					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128351144	128351144	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr2:128351144G>A	ENST00000389524.4	+	18	2222	c.2169G>A	c.(2167-2169)atG>atA	p.M723I	MYO7B_ENST00000409816.2_Missense_Mutation_p.M723I|MYO7B_ENST00000428314.1_Missense_Mutation_p.M723I			Q6PIF6	MYO7B_HUMAN	myosin VIIB	723	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		TCCGCCAGATGACCCTGGGCA	0.622000													31	57					0	0	1	0	0
TMED3	23423	broad.mit.edu	37	15	79606305	79606305	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr15:79606305C>T	ENST00000299705.5	+	2	563	c.375C>T	c.(373-375)ccC>ccT	p.P125P	TMED3_ENST00000424155.2_Silent_p.P125P|TMED3_ENST00000536821.1_Silent_p.P125P	NM_007364.2	NP_031390.1	Q9Y3Q3	TMED3_HUMAN	transmembrane emp24 protein transport domain containing 3	125					protein transport	ER-Golgi intermediate compartment membrane|Golgi apparatus|integral to membrane				large_intestine(3)|lung(4)|ovary(1)|skin(1)	9						ATGAGCCTCCCATTCTCCCAG	0.507000													19	61					0	0	1	0	0
CYP11B2	1585	broad.mit.edu	37	8	143999219	143999219	+	Missense_Mutation	SNP	G	G	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr8:143999219G>T	ENST00000323110.2	-	1	40	c.38C>A	c.(37-39)gCg>gAg	p.A13E		NM_000498.3	NP_000489.3	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 2	13					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity			cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(22)|ovary(3)|upper_aerodigestive_tract(3)	39	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	CAGCCAGGGCGCTGCCACGCA	0.632000									Familial Hyperaldosteronism type I				33	121					1.36615e-20	1.48621e-20	1	1	0
MUC4	4585	broad.mit.edu	37	3	195492231	195492231	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:195492231G>A	ENST00000463781.3	-	9	14167	c.13708C>T	c.(13708-13710)Cgg>Tgg	p.R4570W	MUC4_ENST00000349607.4_Missense_Mutation_p.R283W|MUC4_ENST00000346145.4_Missense_Mutation_p.R334W|MUC4_ENST00000475231.1_Missense_Mutation_p.R4518W	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	1327					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.R4570W(1)|p.R4442W(1)|p.R334W(1)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		CTGGGCCACCGAGGCTGGCTC	0.627000													12	36					0	0	1	0	0
WDR46	9277	broad.mit.edu	37	6	33248649	33248649	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:33248649G>A	ENST00000374617.4	-	11	1587	c.1231C>T	c.(1231-1233)Cag>Tag	p.Q411*	B3GALT4_ENST00000606990.1_Intron	NM_001164267.1|NM_005452.5	NP_001157739.1|NP_005443.3	O15213	WDR46_HUMAN	WD repeat domain 46	411										NS(1)|breast(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)	20						AGTCCCCTCTGGGAGAAGGCC	0.632000													4	63					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32633525	32633525	+	Missense_Mutation	SNP	G	G	A	rs147409173		TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr9:32633525G>A	ENST00000242310.4	-	1	2142	c.2053C>T	c.(2053-2055)Cgc>Tgc	p.R685C	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	685					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding	p.R685C(1)		breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TGAGGTGTGCGCATAAAAAAC	0.448000													25	59					0	0	1	0	0
DHDDS	79947	broad.mit.edu	37	1	26795534	26795534	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:26795534G>C	ENST00000360009.2	+	9	994	c.917G>C	c.(916-918)aGa>aCa	p.R306T	DHDDS_ENST00000525682.2_Missense_Mutation_p.R271T|DHDDS_ENST00000526219.1_Missense_Mutation_p.R266T|DHDDS_ENST00000236342.7_Missense_Mutation_p.R305T	NM_024887.3|NM_205861.2	NP_079163.2|NP_995583.1	Q86SQ9	DHDDS_HUMAN	dehydrodolichyl diphosphate synthase	305							protein binding|transferase activity, transferring alkyl or aryl (other than methyl) groups			breast(5)|endometrium(2)|large_intestine(2)|lung(4)|stomach(1)|urinary_tract(1)	15		all_cancers(24;2.04e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.0161)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.166)|LUSC - Lung squamous cell carcinoma(448;0.239)		CTCTCGGCCAGACGGGAAGAG	0.637000													16	19					0	0	1	0	0
ACTN4	81	broad.mit.edu	37	19	39214899	39214899	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:39214899G>A	ENST00000252699.2	+	15	1871	c.1795G>A	c.(1795-1797)Gag>Aag	p.E599K	ACTN4_ENST00000390009.3_Missense_Mutation_p.E380K|ACTN4_ENST00000424234.2_Missense_Mutation_p.E209K	NM_004924.4	NP_004915.2	O43707	ACTN4_HUMAN	actinin, alpha 4	599					platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|urinary_tract(3)	30	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GAGGATCGCTGAGAGCAACCA	0.622000													4	47					0	0	1	0	0
DRC1	92749	broad.mit.edu	37	2	26667762	26667762	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr2:26667762C>T	ENST00000288710.2	+	10	1416	c.1342C>T	c.(1342-1344)Cag>Tag	p.Q448*	DRC1_ENST00000483675.1_3'UTR	NM_145038.2	NP_659475.2			dynein regulatory complex subunit 1 homolog (Chlamydomonas)																		gcctatttctcAGCAGCCCCA	0.527000													10	31					0	0	1	0	0
NRROS	375387	broad.mit.edu	37	3	196386658	196386658	+	Silent	SNP	C	C	A	rs146517885		TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:196386658C>A	ENST00000328557.4	+	3	347	c.144C>A	c.(142-144)ctC>ctA	p.L48L		NM_198565.1	NP_940967.1			negative regulator of reactive oxygen species																		GGCAGAGCCTCGCTTCGGTGC	0.642000													11	18					0.0167234	0.0168707	1	1	0
CPSF1	29894	broad.mit.edu	37	8	145622980	145622980	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr8:145622980C>T	ENST00000349769.3	-	21	2282	c.2188G>A	c.(2188-2190)Gag>Aag	p.E730K		NM_013291.2	NP_037423.2	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1, 160kDa	730					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding	p.E730K(1)		NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CCCAGGCCCTCGGCCTCCGGG	0.716000													3	27					0	0	1	0	0
KIAA1244	57221	broad.mit.edu	37	6	138559753	138559753	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:138559753G>A	ENST00000251691.4	+	6	694	c.528G>A	c.(526-528)caG>caA	p.Q176Q		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	176					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		AGTTACGACAGAGGCAGGAGA	0.547000													24	50					0	0	1	0	0
C16orf3	750	broad.mit.edu	37	16	90095737	90095737	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr16:90095737G>A	ENST00000408886.2	-	1	572	c.14C>T	c.(13-15)tCt>tTt	p.S5F	GAS8_ENST00000540721.1_Intron|GAS8_ENST00000536122.1_Intron|GAS8_ENST00000268699.4_Intron	NM_001214.3	NP_001205.3	O95177	CP003_HUMAN	chromosome 16 open reading frame 3	5										large_intestine(1)|lung(2)|prostate(1)	4		all_cancers(9;9.01e-08)|Hepatocellular(780;0.000325)|Lung NSC(15;0.0104)|all_lung(18;0.0239)		BRCA - Breast invasive adenocarcinoma(80;0.0272)		ccccgcagcagaggacagttt	0.537000													23	30					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117710631	117710631	+	Missense_Mutation	SNP	G	G	C	rs149258740	byFrequency	TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:117710631G>C	ENST00000368508.3	-	12	1839	c.1641C>G	c.(1639-1641)atC>atG	p.I547M	GOPC_ENST00000467125.1_Intron|ROS1_ENST00000368507.3_Missense_Mutation_p.I556M	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	547					transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		ATGAGCCAAAGATGACCAAGT	0.507000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								24	31					0	0	1	0	0
CRYBG3	131544	broad.mit.edu	37	3	97634463	97634463	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:97634463C>T	ENST00000182096.4	+	14	2344	c.2280C>T	c.(2278-2280)ctC>ctT	p.L760L		NM_153605.3	NP_705833.3			beta-gamma crystallin domain containing 3											breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(10)|stomach(1)|upper_aerodigestive_tract(2)	32						GCTGGCTCCTCTATTACCAAG	0.438000													12	137					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182359504	182359504	+	Nonsense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr2:182359504C>G	ENST00000397033.2	+	12	1734	c.1304C>G	c.(1303-1305)tCa>tGa	p.S435*		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	435					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	CAGTCTATATCAGGACAAATT	0.308000													27	57					0	0	1	0	0
ZNF576	79177	broad.mit.edu	37	19	44103387	44103387	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:44103387C>T	ENST00000336564.4	+	3	644	c.490C>T	c.(490-492)Cgg>Tgg	p.R164W	ZNF576_ENST00000528387.1_Missense_Mutation_p.R164W|ZNF576_ENST00000391965.2_Missense_Mutation_p.R164W|SRRM5_ENST00000607544.1_Intron|ZNF576_ENST00000529930.1_Missense_Mutation_p.R164W|SRRM5_ENST00000526798.1_Intron|ZNF576_ENST00000525771.1_Missense_Mutation_p.R164W|ZNF576_ENST00000533118.1_Missense_Mutation_p.R164W	NM_001145347.1	NP_001138819.1	Q9H609	ZN576_HUMAN	zinc finger protein 576	164					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|prostate(1)	2		Prostate(69;0.0199)				ACACTACATTCGGCATGCCCG	0.617000													6	18					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75983129	75983129	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr15:75983129C>T	ENST00000308508.5	-	3	369	c.277G>A	c.(277-279)Gag>Aag	p.E93K		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	93	Globular or compact configuration stabilized by disulfide bonds.|Laminin G-like 1.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						AGCCTCAGCTCCTCCTGGCCC	0.557000													31	33					0	0	1	0	0
CCER1	196477	broad.mit.edu	37	12	91347850	91347850	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:91347850C>A	ENST00000358859.2	-	1	1103	c.670G>T	c.(670-672)Gag>Tag	p.E224*	CCER1_ENST00000548187.1_Intron	NM_152638.2	NP_689851.1			coiled-coil glutamate-rich protein 1																		GGGGAGGCCTCGCCGCTCACC	0.622000													15	129					1.5739e-10	1.68029e-10	1	1	0
CCHCR1	54535	broad.mit.edu	37	6	31122377	31122377	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:31122377C>T	ENST00000396268.3	-	4	885	c.697G>A	c.(697-699)Gag>Aag	p.E233K	CCHCR1_ENST00000451521.2_Missense_Mutation_p.E197K|CCHCR1_ENST00000480060.1_Intron|CCHCR1_ENST00000376266.5_Missense_Mutation_p.E144K|CCHCR1_ENST00000396263.2_Missense_Mutation_p.E144K	NM_001105563.1|NM_001105564.1	NP_001099033.1|NP_001099034.1	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1	144					cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(13)|skin(1)	23						CGCAGGCCCTCAGCCTCAGCT	0.652000													37	201					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130282123	130282123	+	Missense_Mutation	SNP	C	C	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:130282123C>A	ENST00000358511.6	+	2	307	c.276C>A	c.(274-276)aaC>aaA	p.N92K	COL6A6_ENST00000453409.2_Missense_Mutation_p.N92K	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	92	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						CCATGCTGAACCACCTAAGGA	0.522000													11	33					4.68919e-08	4.95993e-08	1	1	0
IGHG1	3500	broad.mit.edu	37	14	106208521	106208521	+	RNA	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr14:106208521G>A	ENST00000390548.2	-	0	378																											GGTTTTGGGGGGAAGAGGAAG	0.617000													3	67					0	0	1	0	0
MCM8	84515	broad.mit.edu	37	20	5935787	5935787	+	Missense_Mutation	SNP	A	A	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr20:5935787A>G	ENST00000378896.3	+	5	753	c.376A>G	c.(376-378)Aaa>Gaa	p.K126E	MCM8_ENST00000378883.1_Missense_Mutation_p.K126E|MCM8_ENST00000378886.2_Missense_Mutation_p.K126E|MCM8_ENST00000265187.4_Missense_Mutation_p.K126E	NM_001281520.1|NM_032485.4|NM_182802.1	NP_001268449.1|NP_115874.3|NP_877954.1	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	126					cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	23						GGTAGATTTTAAAGAACTGAC	0.338000													34	55					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117840411	117840411	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr9:117840411C>T	ENST00000350763.4	-	7	2896	c.2485G>A	c.(2485-2487)Gag>Aag	p.E829K	TNC_ENST00000346706.3_Missense_Mutation_p.E829K|TNC_ENST00000345230.3_Missense_Mutation_p.E829K|TNC_ENST00000542877.1_Missense_Mutation_p.E829K|TNC_ENST00000535648.1_Missense_Mutation_p.E829K|TNC_ENST00000537320.1_Missense_Mutation_p.E829K|TNC_ENST00000423613.2_Missense_Mutation_p.E829K|TNC_ENST00000340094.3_Missense_Mutation_p.E829K|TNC_ENST00000341037.4_Missense_Mutation_p.E829K	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	829	Fibronectin type-III 3.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						CCATCGATCTCAGCCAGGGGC	0.557000													13	4					0	0	1	0	0
MMP17	4326	broad.mit.edu	37	12	132325224	132325224	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:132325224G>A	ENST00000360564.1	+	4	631	c.529G>A	c.(529-531)Gag>Aag	p.E177K	MMP17_ENST00000535291.1_Missense_Mutation_p.E93K	NM_016155.4	NP_057239.4	Q9ULZ9	MMP17_HUMAN	matrix metallopeptidase 17 (membrane-inserted)	177					proteolysis	anchored to membrane|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			endometrium(1)|large_intestine(3)|lung(1)	5	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.82e-07)|Epithelial(86;1.51e-06)|all cancers(50;2.35e-05)		GAACTTCCACGAGGTGGCGGG	0.667000													16	48					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47399666	47399666	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:47399666C>G	ENST00000310638.4	-	9	1205	c.1174G>C	c.(1174-1176)Gag>Cag	p.E392Q	CYP4A11_ENST00000371904.4_Missense_Mutation_p.E393Q|CYP4A11_ENST00000462347.1_Missense_Mutation_p.E294Q|CYP4A11_ENST00000457840.2_3'UTR|CYP4A11_ENST00000496519.1_5'UTR|CYP4A11_ENST00000371905.1_Missense_Mutation_p.E392Q	NM_000778.3	NP_000769.2	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	392					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	GTGCTGAGCTCTCTGCCAATG	0.572000													13	18					0	0	1	0	0
SPG20	23111	broad.mit.edu	37	13	36878631	36878631	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr13:36878631G>A	ENST00000451493.1	-	9	2089	c.1872C>T	c.(1870-1872)ctC>ctT	p.L624L	SPG20_ENST00000355182.4_Silent_p.L624L|SPG20_ENST00000494062.2_Silent_p.L624L|SPG20_ENST00000438666.2_Silent_p.L624L	NM_001142295.1	NP_001135767.1	Q8N0X7	SPG20_HUMAN	spastic paraplegia 20 (Troyer syndrome)	624					cell death	cytoplasm	ubiquitin protein ligase binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	27		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;2.42e-08)|Epithelial(112;1.58e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00128)|BRCA - Breast invasive adenocarcinoma(63;0.0125)|GBM - Glioblastoma multiforme(144;0.026)		AGTCCTCAAGGAGAGTGTGTC	0.433000													29	138					0	0	1	0	0
DHX36	170506	broad.mit.edu	37	3	154032879	154032879	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:154032879C>G	ENST00000496811.1	-	3	639	c.559G>C	c.(559-561)Gat>Cat	p.D187H	DHX36_ENST00000308361.6_Missense_Mutation_p.D187H|DHX36_ENST00000329463.5_Missense_Mutation_p.D187H|DHX36_ENST00000544526.1_Missense_Mutation_p.D187H	NM_020865.2	NP_065916.2	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	187						cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(7)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	35			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TTTTGTAAATCTTCCAATAAT	0.284000													9	37					0	0	1	0	0
ACTN4	81	broad.mit.edu	37	19	39214845	39214845	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:39214845G>A	ENST00000252699.2	+	15	1817	c.1741G>A	c.(1741-1743)Gat>Aat	p.D581N	ACTN4_ENST00000390009.3_Missense_Mutation_p.D362N|ACTN4_ENST00000424234.2_Missense_Mutation_p.D191N	NM_004924.4	NP_004915.2	O43707	ACTN4_HUMAN	actinin, alpha 4	581					platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|urinary_tract(3)	30	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GCCGGACGCCGATAGGGAGCG	0.652000													5	55					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19757026	19757026	+	Missense_Mutation	SNP	C	C	A	rs142904822		TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:19757026C>A	ENST00000357324.6	-	23	3262	c.3236G>T	c.(3235-3237)cGg>cTg	p.R1079L	ATP13A1_ENST00000291503.5_Missense_Mutation_p.R961L	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	1079					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						CTCGGGGCTCCGGGCCTGGGC	0.577000													16	10					5.3912e-06	5.59903e-06	1	1	0
ZNF638	27332	broad.mit.edu	37	2	71591275	71591275	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr2:71591275C>T	ENST00000409544.1	+	5	2240	c.1610C>T	c.(1609-1611)tCc>tTc	p.S537F	ZNF638_ENST00000410075.1_3'UTR|ZNF638_ENST00000377802.2_Missense_Mutation_p.S537F|ZNF638_ENST00000264447.4_Missense_Mutation_p.S537F|ZNF638_ENST00000355812.3_Missense_Mutation_p.S537F	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	537	Arg-rich.				RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						AGATCCAGATCCAGATCCCGT	0.438000													22	51					0	0	1	0	0
LLPH	84298	broad.mit.edu	37	12	66517668	66517668	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:66517668C>T	ENST00000266604.2	-	3	412	c.342G>A	c.(340-342)ggG>ggA	p.G114G	LLPH_ENST00000446587.2_Silent_p.G114G	NM_032338.3	NP_115714.1	Q9BRT6	LLPH_HUMAN	LLP homolog, long-term synaptic facilitation (Aplysia)	114	Lys-rich.									central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(1)|skin(1)	5						CTTTGCTTTTCCCCTTTCTTT	0.428000													25	102					0	0	1	0	0
FKBP5	2289	broad.mit.edu	37	6	35610601	35610601	+	Translation_Start_Site	SNP	T	T	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:35610601T>C	ENST00000542713.1	-	2	158	c.1A>G	c.(1-3)Atg>Gtg	p.M1V	FKBP5_ENST00000536438.1_Start_Codon_SNP_p.M1V|FKBP5_ENST00000357266.4_Start_Codon_SNP_p.M1V|FKBP5_ENST00000539068.1_Start_Codon_SNP_p.M1V|FKBP5_ENST00000540787.1_Intron	NM_001145777.1	NP_001139249.1	Q13451	FKBP5_HUMAN	FK506 binding protein 5	1					protein folding	cytoplasm|membrane|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(3)|urinary_tract(2)	17						TCAGTAGTCATTGTCTTTTAA	0.408000													48	59					0	0	1	0	0
PGP	283871	broad.mit.edu	37	16	2263919	2263919	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr16:2263919C>G	ENST00000333503.7	-	2	805	c.776G>C	c.(775-777)gGa>gCa	p.G259A		NM_001042371.2	NP_001035830.1	A6NDG6	PGP_HUMAN	phosphoglycolate phosphatase	259					carbohydrate metabolic process		phosphoglycolate phosphatase activity			skin(1)	1						CAGGCGGTCTCCCACCATGAC	0.607000													17	47					0	0	1	0	0
TFB1M	51106	broad.mit.edu	37	6	155635549	155635549	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:155635549C>T	ENST00000367166.4	-	1	69	c.14G>A	c.(13-15)gGa>gAa	p.G5E	TFB1M_ENST00000480390.1_5'UTR	NM_016020.3	NP_057104.2	Q8WVM0	TFB1M_HUMAN	transcription factor B1, mitochondrial	5					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	DNA binding|protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity			lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;1.48e-12)|BRCA - Breast invasive adenocarcinoma(81;0.0131)		GCTGAGTTTTCCGGAGGCAGC	0.557000													3	10					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241706709	241706709	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr2:241706709G>A	ENST00000498729.2	-	18	1797	c.1551C>T	c.(1549-1551)ctC>ctT	p.L517L	KIF1A_ENST00000320389.7_Silent_p.L508L	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	508	FHA.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		TGATGTAGTAGAGCAGGCACT	0.617000													15	21					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78380889	78380889	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:78380889G>A	ENST00000278550.7	-	32	6963	c.6501C>T	c.(6499-6501)acC>acT	p.T2167T		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		CATACTGGACGGTCATCCAGT	0.507000													5	34					0	0	1	0	0
SSX6	280657	broad.mit.edu	37	X	47979502	47979502	+	RNA	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chrX:47979502C>T	ENST00000509958.1	+	0	246																				large_intestine(6)|lung(4)|skin(2)|stomach(1)	13						ACGACACATGCCCATGATGAG	0.522000													45	17					0	0	1	0	0
HIST2H3D	653604	broad.mit.edu	37	1	149784905	149784905	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:149784905C>T	ENST00000331491.1	-	1	331	c.332G>A	c.(331-333)tGc>tAc	p.C111Y		NM_001123375.2	NP_001116847.1	Q71DI3	H32_HUMAN	histone cluster 2, H3d	111					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding|protein binding			biliary_tract(1)|endometrium(1)|large_intestine(1)|liver(1)|lung(3)	7						ATGGATGGCGCACAGGTTCGT	0.622000													11	59					0	0	1	0	0
WDTC1	23038	broad.mit.edu	37	1	27623546	27623546	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:27623546G>C	ENST00000319394.3	+	11	1492	c.957G>C	c.(955-957)caG>caC	p.Q319H	WDTC1_ENST00000361771.3_Missense_Mutation_p.Q318H	NM_001276252.1|NM_015023.3	NP_001263181.1|NP_055838.2	Q8N5D0	WDTC1_HUMAN	WD and tetratricopeptide repeats 1	319							protein binding	p.Q318Q(1)		central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|skin(1)	21		all_cancers(24;3.12e-19)|all_epithelial(13;4.18e-18)|Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.00257)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0443)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;1.02e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00201)|STAD - Stomach adenocarcinoma(196;0.00321)|READ - Rectum adenocarcinoma(331;0.0476)		CAGAAGTCCAGAATGGCAAGA	0.542000											OREG0013279	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	30					0	0	1	0	0
FASN	2194	broad.mit.edu	37	17	80051636	80051636	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr17:80051636C>G	ENST00000306749.2	-	4	510	c.292G>C	c.(292-294)Gat>Cat	p.D98H		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	98	Beta-ketoacyl synthase (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	CGGAGTGAATCTGGGTTGATG	0.672000													14	52					0	0	1	0	0
AGFG2	3268	broad.mit.edu	37	7	100151029	100151029	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr7:100151029C>T	ENST00000300176.4	+	4	613	c.491C>T	c.(490-492)cCt>cTt	p.P164L	AGFG2_ENST00000474713.1_3'UTR|AGFG2_ENST00000262935.4_Intron	NM_006076.4	NP_006067.3	O95081	AGFG2_HUMAN	ArfGAP with FG repeats 2	164					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GCCTCCACCCCTGTGCAGGGC	0.547000													15	220					0	0	1	0	0
FCHSD1	89848	broad.mit.edu	37	5	141027612	141027612	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr5:141027612C>T	ENST00000435817.2	-	8	678	c.628G>A	c.(628-630)Gag>Aag	p.E210K	FCHSD1_ENST00000522126.1_Missense_Mutation_p.E134K|FCHSD1_ENST00000519800.1_Missense_Mutation_p.E208K|FCHSD1_ENST00000522783.1_Missense_Mutation_p.E208K	NM_033449.2	NP_258260.1	Q86WN1	FCSD1_HUMAN	FCH and double SH3 domains 1	210									FCHSD1/BRAF(2)	central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCAGGTACTCATTGCGGGCT	0.567000													5	11					0	0	1	0	0
LIPC	3990	broad.mit.edu	37	15	58838138	58838138	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr15:58838138G>C	ENST00000414170.3	+	6	1059	c.772G>C	c.(772-774)Gag>Cag	p.E258Q	LIPC_ENST00000433326.2_Missense_Mutation_p.E197Q|LIPC_ENST00000356113.6_Missense_Mutation_p.E258Q|LIPC_ENST00000299022.5_Missense_Mutation_p.E258Q			P11150	LIPC_HUMAN	lipase, hepatic	258					cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)		CCACTTCCTAGAGCTCTACAG	0.572000													21	42					0	0	1	0	0
TNK2	10188	broad.mit.edu	37	3	195595194	195595194	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:195595194C>T	ENST00000333602.6	-	12	2547	c.1930G>A	c.(1930-1932)Gac>Aac	p.D644N	TNK2_ENST00000381916.2_Missense_Mutation_p.D722N|TNK2_ENST00000428187.1_Missense_Mutation_p.D676N|TNK2_ENST00000392400.1_Missense_Mutation_p.D644N	NM_005781.4	NP_005772.3	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2	644	Pro-rich.|Required for interaction with SRC.			Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(11)|ovary(3)|prostate(4)|skin(2)|stomach(1)|urinary_tract(1)	29	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	ATCTCAAAGTCATCCTCATCC	0.706000													15	24					0	0	1	0	0
EPG5	57724	broad.mit.edu	37	18	43437885	43437885	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr18:43437885C>T	ENST00000282041.5	-	42	7409	c.7375G>A	c.(7375-7377)Gag>Aag	p.E2459K	EPG5_ENST00000585906.1_5'UTR	NM_020964.2	NP_066015.2	Q9HCE0	EPG5_HUMAN	ectopic P-granules autophagy protein 5 homolog (C. elegans)	2459					autophagy					NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(35)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	95						AGTCTCTCCTCAGCCACGAGG	0.517000													42	22					0	0	1	0	0
TMEM59L	25789	broad.mit.edu	37	19	18729068	18729068	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:18729068C>T	ENST00000600490.1	+	7	953	c.768C>T	c.(766-768)ctC>ctT	p.L256L	TMEM59L_ENST00000262817.3_Silent_p.L256L			Q9UK28	TM59L_HUMAN	transmembrane protein 59-like	256						Golgi membrane|integral to membrane|membrane fraction				breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(2)	13						ATGACTTCCTCAGTTGCATGT	0.637000													4	16					0	0	1	0	0
TBC1D1	23216	broad.mit.edu	37	4	38051359	38051359	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr4:38051359C>T	ENST00000261439.4	+	11	2105	c.1750C>T	c.(1750-1752)Ctg>Ttg	p.L584L	TBC1D1_ENST00000508802.1_Silent_p.L584L	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	584						nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						GCCAGCTCCGCTGTCGCCCCA	0.637000													27	38					0	0	1	0	0
TIMP1	7076	broad.mit.edu	37	X	47445162	47445162	+	Missense_Mutation	SNP	T	T	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chrX:47445162T>G	ENST00000377018.2	+	3	1095	c.531T>G	c.(529-531)tgT>tgG	p.C177W	SYN1_ENST00000340666.4_Intron|SYN1_ENST00000295987.7_Intron|TIMP1_ENST00000456754.2_3'UTR|TIMP1_ENST00000218388.4_Intron|TIMP1_ENST00000377017.1_Intron			P01033	TIMP1_HUMAN	TIMP metallopeptidase inhibitor 1	0					erythrocyte maturation|negative regulation of membrane protein ectodomain proteolysis|platelet activation|platelet degranulation|positive regulation of cell proliferation	platelet alpha granule lumen	metal ion binding|metalloendopeptidase inhibitor activity|protein binding			endometrium(1)|large_intestine(2)	3						CTATTCTGTGTCCCTGTGGCT	0.572000													4	0					0	0	1	0	0
PPP1R7	5510	broad.mit.edu	37	2	242092934	242092934	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr2:242092934G>A	ENST00000234038.6	+	2	570	c.96G>A	c.(94-96)ggG>ggA	p.G32G	PPP1R7_ENST00000407025.1_Silent_p.G32G|PPP1R7_ENST00000404405.3_Silent_p.G32G|PPP1R7_ENST00000401987.1_Intron|PPP1R7_ENST00000272983.8_Intron|PPP1R7_ENST00000402734.1_Intron|PPP1R7_ENST00000406106.3_Silent_p.G32G	NM_001282412.1|NM_001282413.1|NM_002712.1	NP_001269341.1|NP_001269342.1|NP_002703.1	Q15435	PP1R7_HUMAN	protein phosphatase 1, regulatory subunit 7	32						cytoplasm|nucleus	protein binding|protein phosphatase type 1 regulator activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|ovary(3)	23		all_cancers(19;6.1e-33)|all_epithelial(40;1.07e-13)|Breast(86;0.000141)|Renal(207;0.00528)|all_lung(227;0.0446)|Ovarian(221;0.104)|Lung NSC(271;0.115)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.92e-32)|all cancers(36;5.35e-29)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-14)|Kidney(56;4.23e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.24e-08)|BRCA - Breast invasive adenocarcinoma(100;3.56e-06)|Lung(119;0.000588)|LUSC - Lung squamous cell carcinoma(224;0.0048)|Colorectal(34;0.0137)|COAD - Colon adenocarcinoma(134;0.096)		ATGAAGAAGGGAAGAAACACA	0.552000													31	40					0	0	1	0	0
PRPF31	26121	broad.mit.edu	37	19	54622010	54622010	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:54622010G>A	ENST00000321030.4	+	3	584	c.235G>A	c.(235-237)Gaa>Aaa	p.E79K	PRPF31_ENST00000419967.1_Missense_Mutation_p.E79K|PRPF31_ENST00000498612.1_3'UTR|PRPF31_ENST00000391755.1_Missense_Mutation_p.E79K	NM_015629.3	NP_056444.3	Q8WWY3	PRP31_HUMAN	pre-mRNA processing factor 31	79					assembly of spliceosomal tri-snRNP	Cajal body|MLL1 complex|nuclear speck|U4 snRNP|U4/U6 x U5 tri-snRNP complex|U4atac snRNP	RNA binding|snRNP binding			breast(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(2)|urinary_tract(3)	12	all_cancers(19;0.00681)|all_epithelial(19;0.00362)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CAAAGCTTCAGAAGGTGCTTC	0.517000													36	63					0	0	1	0	0
ZNF101	94039	broad.mit.edu	37	19	19790110	19790110	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:19790110C>A	ENST00000592502.1	+	4	422	c.312C>A	c.(310-312)tgC>tgA	p.C104*	ZNF101_ENST00000415784.2_5'UTR|ZNF101_ENST00000444249.2_3'UTR			Q8IZC7	ZN101_HUMAN	zinc finger protein 101	104					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(4)|ovary(2)|prostate(1)	17						CATGCAAATGCAGCGTGTGTG	0.478000													30	36					6.38683e-12	6.88275e-12	1	1	0
MYH15	22989	broad.mit.edu	37	3	108147692	108147692	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:108147692C>T	ENST00000273353.3	-	28	3465	c.3409G>A	c.(3409-3411)Gaa>Aaa	p.E1137K		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1137						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						GTGGTCCTTTCAGCTTCTAGT	0.423000													32	87					0	0	1	0	0
MTMR2	8898	broad.mit.edu	37	11	95595480	95595480	+	Silent	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr11:95595480G>A	ENST00000393223.3	-	6	759	c.97C>T	c.(97-99)Ctg>Ttg	p.L33L	MTMR2_ENST00000346299.5_Silent_p.L105L|MTMR2_ENST00000352297.7_Silent_p.L33L|MTMR2_ENST00000484818.1_5'UTR|MTMR2_ENST00000409459.1_Silent_p.L33L	NM_001243571.1|NM_201278.2	NP_001230500.1|NP_958435.1	Q13614	MTMR2_HUMAN	myotubularin related protein 2	105	Ser-rich.					nucleus	inositol or phosphatidylinositol phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	19		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GTGACAGTCAGAGTTCCTCGT	0.353000													15	44					0	0	1	0	0
SRPK3	26576	broad.mit.edu	37	X	153047051	153047051	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chrX:153047051G>C	ENST00000489426.1	+	9	2849	c.483G>C	c.(481-483)tgG>tgC	p.W161C	SRPK3_ENST00000370108.3_Missense_Mutation_p.W94C|SRPK3_ENST00000370100.1_Missense_Mutation_p.W52C|SRPK3_ENST00000370101.3_Missense_Mutation_p.W94C|SRPK3_ENST00000393786.3_Missense_Mutation_p.W94C|SRPK3_ENST00000370104.1_Missense_Mutation_p.W94C			Q9UPE1	SRPK3_HUMAN	SRSF protein kinase 3	94	Protein kinase.				cell differentiation|muscle organ development|muscle tissue development		ATP binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(2)|lung(4)|ovary(2)|pancreas(2)|urinary_tract(1)	13	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					CCACCGTCTGGCTCTGCTGGG	0.672000													12	7					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155727116	155727116	+	Splice_Site	SNP	T	T	G			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:155727116T>G	ENST00000437809.1	-	26	5376		c.e26-2		GON4L_ENST00000368331.1_Splice_Site|GON4L_ENST00000271883.5_Splice_Site	NM_001282856.1	NP_001269785.1	Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)						regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TGTCTTGAGCTGAGGAGAGTC	0.537000													4	49					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144857635	144857635	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:144857635G>A	ENST00000369359.4	-	42	6865	c.6827C>T	c.(6826-6828)aCg>aTg	p.T2276M	PDE4DIP_ENST00000369356.4_Missense_Mutation_p.T2140M|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.T2034M|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.T2225M|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.T2140M|PDE4DIP_ENST00000524974.1_5'UTR			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	2140					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GATTATGGGCGTTTCTGAGCC	0.483000			T	PDGFRB	MPD								13	183					0	0	1	0	0
CASP8	841	broad.mit.edu	37	2	202136277	202136277	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr2:202136277C>T	ENST00000358485.4	+	3	717	c.521C>T	c.(520-522)tCa>tTa	p.S174L	CASP8_ENST00000432109.2_Missense_Mutation_p.S115L|CASP8_ENST00000264274.9_Missense_Mutation_p.S115L|CASP8_ENST00000392259.2_Missense_Mutation_p.S115L|CASP8_ENST00000392266.3_Missense_Mutation_p.S115L|CASP8_ENST00000323492.7_Missense_Mutation_p.S115L|CASP8_ENST00000392258.3_Missense_Mutation_p.S115L|CASP8_ENST00000264275.5_Missense_Mutation_p.S147L	NM_001080125.1	NP_001073594.1	Q14790	CASP8_HUMAN	caspase 8, apoptosis-related cysteine peptidase	115	DED 2.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding			breast(5)|cervix(2)|endometrium(6)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(9)|urinary_tract(3)	52						GTGAGCAGATCAGAATTGAGG	0.373000										HNSCC(4;0.00038)			14	54					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51872073	51872073	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr20:51872073C>T	ENST00000371497.5	+	2	2963	c.2076C>T	c.(2074-2076)atC>atT	p.I692I	TSHZ2_ENST00000603338.2_Silent_p.I689I|TSHZ2_ENST00000329613.6_Silent_p.I689I	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	692					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			TGCCATGCATCAACCCACTCA	0.627000													8	30					0	0	1	0	0
GPS2	2874	broad.mit.edu	37	17	7217397	7217397	+	Splice_Site	SNP	A	A	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr17:7217397A>C	ENST00000575474.1	-	13	1889		c.e13+1		GPS2_ENST00000391950.3_Splice_Site|GPS2_ENST00000389167.5_Splice_Site|GPS2_ENST00000380728.2_Splice_Site																							TTTAGTCCTCACCCTGCATGC	0.532000													54	35					0	0	1	0	0
CCHCR1	54535	broad.mit.edu	37	6	31122383	31122383	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:31122383C>T	ENST00000396268.3	-	4	879	c.691G>A	c.(691-693)Gag>Aag	p.E231K	CCHCR1_ENST00000451521.2_Missense_Mutation_p.E195K|CCHCR1_ENST00000480060.1_Intron|CCHCR1_ENST00000376266.5_Missense_Mutation_p.E142K|CCHCR1_ENST00000396263.2_Missense_Mutation_p.E142K	NM_001105563.1|NM_001105564.1	NP_001099033.1|NP_001099034.1	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1	142					cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(13)|skin(1)	23						CCCTCAGCCTCAGCTCGGCCG	0.662000													34	183					0	0	1	0	0
SLC25A24	29957	broad.mit.edu	37	1	108735220	108735220	+	Silent	SNP	G	G	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:108735220G>C	ENST00000370041.4	-	1	220	c.24C>G	c.(22-24)ctC>ctG	p.L8L	SLC25A24_ENST00000565488.1_Intron	NM_213651.2	NP_998816.1	Q6NUK1	SCMC1_HUMAN	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24	27					transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	16		all_epithelial(167;3.72e-05)|all_lung(203;0.000567)|Lung NSC(277;0.0011)|Melanoma(281;0.211)		Colorectal(144;0.0345)|Lung(183;0.0971)|COAD - Colon adenocarcinoma(174;0.127)|Epithelial(280;0.134)		GGTACCAAAAGAGATCTCCGT	0.567000													48	120					0	0	1	0	0
SYT17	51760	broad.mit.edu	37	16	19236069	19236069	+	Silent	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr16:19236069C>T	ENST00000562034.1	+	5	4752	c.954C>T	c.(952-954)ttC>ttT	p.F318F	SYT17_ENST00000568433.1_Silent_p.F73F|SYT17_ENST00000568115.1_Silent_p.F318F|SYT17_ENST00000355377.2_Silent_p.F379F|SYT17_ENST00000562711.2_Silent_p.F375F			Q9BSW7	SYT17_HUMAN	synaptotagmin XVII	379						membrane|synaptic vesicle	transporter activity			NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	17						AGACGTCCTTCTTAAGGGGCA	0.428000													28	70					0	0	1	0	0
ACTB	60	broad.mit.edu	37	7	5568242	5568242	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr7:5568242C>T	ENST00000331789.5	-	4	663	c.472G>A	c.(472-474)Ggg>Agg	p.G158R		NM_001101.3	NP_001092.1	P60709	ACTB_HUMAN	actin, beta	158					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(2)|prostate(2)	8		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		TGGGTGACCCCGTCACCGGAG	0.607000													14	53					0	0	1	0	0
RUSC1	23623	broad.mit.edu	37	1	155291878	155291878	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:155291878C>T	ENST00000368352.5	+	2	465	c.314C>T	c.(313-315)tCa>tTa	p.S105L	RUSC1_ENST00000368354.3_Missense_Mutation_p.S105L|RUSC1-AS1_ENST00000443642.1_RNA|RUSC1-AS1_ENST00000450199.1_RNA	NM_001105203.1	NP_001098673.1	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1	105						cytoplasm|nucleolus	SH3/SH2 adaptor activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(2)|skin(1)|urinary_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			TGCTCCTCCTCACTCAGCTCC	0.637000													5	39					0	0	1	0	0
CCDC71	64925	broad.mit.edu	37	3	49200762	49200762	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:49200762G>A	ENST00000321895.6	-	2	986	c.880C>T	c.(880-882)Cgt>Tgt	p.R294C		NM_022903.3	NP_075054.3	Q8IV32	CCD71_HUMAN	coiled-coil domain containing 71	294										endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)	10				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GCTTGGGCACGAGCAGCTTTG	0.632000													13	106					0	0	1	0	0
SYTL1	84958	broad.mit.edu	37	1	27677811	27677811	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:27677811delC	ENST00000543823.1	+	11	1689	c.1227delC	c.(1225-1227)gtcfs	p.V409fs	SYTL1_ENST00000490170.1_3'UTR|SYTL1_ENST00000318074.5_Frame_Shift_Del_p.V397fs			Q8IYJ3	SYTL1_HUMAN	synaptotagmin-like 1	409	C2 2.				exocytosis|intracellular protein transport	extrinsic to plasma membrane|melanosome|soluble fraction	neurexin binding|Rab GTPase binding			NS(1)|large_intestine(4)|lung(5)|ovary(1)|urinary_tract(1)	12		Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.0115)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0908)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-28)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.0013)|KIRC - Kidney renal clear cell carcinoma(1967;0.00158)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		TCAAGTACGTCCCCGCCGGCT	0.677													2	4	---	---	---	---					
PRG4	10216	broad.mit.edu	37	1	186281963	186281968	+	In_Frame_Del	DEL	TCAGCT	TCAGCT	-			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:186281963_186281968delTCAGCT	ENST00000445192.2	+	12	4099_4104	c.4054_4059delTCAGCT	c.(4054-4059)tcagctdel	p.SA1352del	TPR_ENST00000367478.4_3'UTR|PRG4_ENST00000367483.4_In_Frame_Del_p.SA1311del|PRG4_ENST00000367484.3_In_Frame_Del_p.SA881del|PRG4_ENST00000367486.3_In_Frame_Del_p.SA1309del|PRG4_ENST00000367485.4_In_Frame_Del_p.SA1259del	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	1352					cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						TGTGGTTACCTCAGCTATATCACTGC	0.374													19	94	---	---	---	---					
ELF3	1999	broad.mit.edu	37	1	201981563	201981565	+	Splice_Site	DEL	TGG	TGG	-			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:201981563_201981565delTGG	ENST00000359651.3	+	3	3669_3670	c.477_478delTGG	c.(475-480)tttgga>ttga	p.159_160FG>L	ELF3_ENST00000367284.5_Splice_Site_p.159_160FG>L|RP11-510N19.5_ENST00000504773.1_RNA|ELF3_ENST00000495848.1_3'UTR|ELF3_ENST00000367283.3_Splice_Site_p.159_160FG>L			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	159					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						CAGGGCCCTTTGGTGAGAACCCG	0.581													21	44	---	---	---	---					
ZC3H11A	9877	broad.mit.edu	37	1	203786224	203786225	+	Frame_Shift_Ins	INS	-	-	T			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:203786224_203786225insT	ENST00000545588.1	+	2	3853_3854	c.26_27insT	c.(25-30)tattttfs	p.YF9fs	ZC3H11A_ENST00000367214.1_Frame_Shift_Ins_p.YF9fs|ZC3H11A_ENST00000367210.1_Frame_Shift_Ins_p.YF9fs|ZC3H11A_ENST00000332127.4_Frame_Shift_Ins_p.YF9fs|ZC3H11A_ENST00000367212.3_Frame_Shift_Ins_p.YF9fs	NM_001271675.1	NP_001258604.1	O75152	ZC11A_HUMAN	zinc finger CCCH-type containing 11A	9							nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32	all_cancers(21;0.0904)|all_epithelial(62;0.234)		BRCA - Breast invasive adenocarcinoma(75;0.109)			GAAGACTGCTATTTTTTTTTCT	0.371													7	139	---	---	---	---					
RP11-739N20.2	0	broad.mit.edu	37	1	204363978	204363979	+	RNA	INS	-	-	A			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr1:204363978_204363979insA	ENST00000443515.1	+	0	146																											gatttgtttttcaaaaaaaaaa	0.302													3	3	---	---	---	---					
XPC	7508	broad.mit.edu	37	3	14219966	14219968	+	Splice_Site	DEL	CCT	CCT	-	rs72561774		TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:14219966_14219968delCCT	ENST00000285021.7	-	1	315_317	c.101_103delAGG	c.(100-105)gaggat>gat	p.E34del	XPC_ENST00000449060.2_Splice_Site_p.E34del|LSM3_ENST00000306024.3_5'UTR	NM_001145769.1|NM_004628.4	NP_001139241.1|NP_004619.3	Q01831	XPC_HUMAN	xeroderma pigmentosum, complementation group C	34	Glu-rich (acidic).|Poly-Glu.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal	cytoplasm|nucleoplasm|XPC complex	bubble DNA binding|damaged DNA binding|loop DNA binding|protein binding|single-stranded DNA binding	p.E34delE(1)		NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TCGCTCTCACCCTCCTCCTCCTC	0.734			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				9	91	---	---	---	---					
STXBP5L	9515	broad.mit.edu	37	3	121037357	121037362	+	In_Frame_Del	DEL	GAACTT	GAACTT	-			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:121037357_121037362delGAACTT	ENST00000273666.6	+	21	2489_2494	c.2218_2223delGAACTT	c.(2218-2223)gaacttdel	p.EL740del	STXBP5L_ENST00000492541.1_In_Frame_Del_p.EL740del|STXBP5L_ENST00000471454.1_In_Frame_Del_p.EL716del|STXBP5L_ENST00000497029.1_In_Frame_Del_p.EL740del|STXBP5L_ENST00000472879.1_In_Frame_Del_p.EL716del	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	740					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		AGTTCCCCTAGAACTTGAGCGCTGCA	0.350													46	97	---	---	---	---					
RP11-93K22.13	0	broad.mit.edu	37	3	129811873	129811873	+	RNA	DEL	A	A	-	rs71158104		TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr3:129811873delA	ENST00000514010.1	-	0	157				ALG1L2_ENST00000507643.1_RNA																							agtctgtcagaaaaaaaaaaa	0.383													3	4	---	---	---	---					
RP11-254I22.1	0	broad.mit.edu	37	5	95414786	95414787	+	RNA	INS	-	-	TAAAA	rs80243332	by1000genomes	TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr5:95414786_95414787insTAAAA	ENST00000507997.1	+	0	87				CTD-2337A12.1_ENST00000502645.2_RNA|CTD-2337A12.1_ENST00000511775.1_RNA																							acccatgcacttaaagttaaaa	0.361													3	5	---	---	---	---					
HLA-DRB6	3128	broad.mit.edu	37	6	32523365	32523366	+	RNA	INS	-	-	AGAG			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:32523365_32523366insAGAG	ENST00000411500.1	-	0	458					NR_001298.1																						GCAATGTGGATAAAGGGACAGA	0.441													2	4	---	---	---	---					
AIM1	202	broad.mit.edu	37	6	106960705	106960705	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr6:106960705delC	ENST00000369066.3	+	1	976	c.489delC	c.(487-489)ctcfs	p.L163fs		NM_001624.2	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	163							sugar binding			breast(8)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(7)|large_intestine(13)|lung(20)|ovary(5)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	69	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		CCCGCGAGCTCCCGGTCAAGA	0.706													3	3	---	---	---	---					
PRSS3P2	154754	broad.mit.edu	37	7	142481996	142481997	+	RNA	INS	-	-	C			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr7:142481996_142481997insC	ENST00000603901.1	+	0	591					NR_001296.3																						TCCCAAGGTGGGGGGCTGAGGA	0.564													5	8	---	---	---	---					
FAM135B	51059	broad.mit.edu	37	8	139160921	139160921	+	Frame_Shift_Del	DEL	T	T	-			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr8:139160921delT	ENST00000395297.1	-	14	3460	c.3290delA	c.(3289-3291)cagfs	p.Q1097fs		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1097										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TTCTTTGGCCTGATAAAAACT	0.388										HNSCC(54;0.14)			20	33	---	---	---	---					
ZSWIM8	23053	broad.mit.edu	37	10	75559891	75559891	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr10:75559891delC	ENST00000604729.1	+	22	5085	c.4788delC	c.(4786-4788)cacfs	p.H1596fs	ZSWIM8_ENST00000605216.1_Frame_Shift_Del_p.H1591fs|ZSWIM8_ENST00000398706.2_Frame_Shift_Del_p.H1596fs|ZSWIM8_ENST00000604524.1_Frame_Shift_Del_p.H1409fs|ZSWIM8-AS1_ENST00000456638.2_RNA|ZSWIM8_ENST00000603114.1_Frame_Shift_Del_p.H1558fs|RP11-574K11.31_ENST00000603027.1_Intron					zinc finger, SWIM-type containing 8																		ATCCCTACCACACAGAGCCAG	0.607													14	41	---	---	---	---					
MPHOSPH9	10198	broad.mit.edu	37	12	123649869	123649872	+	Frame_Shift_Del	DEL	TCTG	TCTG	-			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr12:123649869_123649872delTCTG	ENST00000606320.1	-	18	2950_2953	c.2744_2747delCAGA	c.(2743-2748)acagagfs	p.TE915fs	MPHOSPH9_ENST00000392425.3_Frame_Shift_Del_p.TE763fs|MPHOSPH9_ENST00000302349.5_Frame_Shift_Del_p.TE763fs|MPHOSPH9_ENST00000541076.2_Frame_Shift_Del_p.TE885fs			Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	763					M phase of mitotic cell cycle	centriole|Golgi membrane				NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(18)|prostate(2)|skin(1)	33	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		GTCCTCTTTCTCTGTCTGTGTCCC	0.328													9	94	---	---	---	---					
TPTE2P2	644623	broad.mit.edu	37	13	52857402	52857402	+	RNA	DEL	A	A	-			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr13:52857402delA	ENST00000451298.1	-	0	303																											ACTTAACGTCAAAAAAAATGT	0.289													2	4	---	---	---	---					
ZFP36L1	677	broad.mit.edu	37	14	69256299	69256300	+	Frame_Shift_Ins	INS	-	-	TG			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr14:69256299_69256300insTG	ENST00000439696.2	-	2	1268_1269	c.967_968insCA	c.(967-969)aacfs	p.N323fs	ZFP36L1_ENST00000555997.1_3'UTR|ZFP36L1_ENST00000336440.3_Frame_Shift_Ins_p.N323fs	NM_001244701.1|NM_004926.3	NP_001231630.1|NP_004917.2	Q07352	TISB_HUMAN	ZFP36 ring finger protein-like 1	323					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|kidney(1)|large_intestine(1)|liver(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(1)	21				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GCGTCTTGAGTTGTCCAAGGTC	0.609											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	75	---	---	---	---					
EIF2AK4	440275	broad.mit.edu	37	15	40268948	40268949	+	Frame_Shift_Ins	INS	-	-	TG			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr15:40268948_40268949insTG	ENST00000263791.5	+	12	2195_2196	c.2152_2153insTG	c.(2152-2154)tcgfs	p.S718fs	EIF2AK4_ENST00000382727.2_Frame_Shift_Ins_p.S718fs	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	718	Protein kinase 2.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		GGGCGAGCGCTCGGCCAGTGCC	0.703													22	43	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102292874	102292876	+	RNA	DEL	CTC	CTC	-			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr15:102292874_102292876delCTC	ENST00000561463.1	+	0	920_922																											AGTTCATCTTCTCAGAGCTGCTG	0.581													4	5	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7578267	7578283	+	Frame_Shift_Del	DEL	AAGATGCTGAGGAGGGG	AAGATGCTGAGGAGGGG	-	rs121912665		TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr17:7578267_7578283delAAGATGCTGAGGAGGGG	ENST00000420246.2	-	6	698_714	c.566_582delCCCCTCCTCAGCATCTT	c.(565-582)gcccctcctcagcatcttfs	p.APPQHL189fs	TP53_ENST00000269305.4_Frame_Shift_Del_p.APPQHL189fs|TP53_ENST00000359597.4_Frame_Shift_Del_p.APPQHL189fs|TP53_ENST00000445888.2_Frame_Shift_Del_p.APPQHL189fs|TP53_ENST00000455263.2_Frame_Shift_Del_p.APPQHL189fs|TP53_ENST00000574684.1_Intron|TP53_ENST00000413465.2_Frame_Shift_Del_p.APPQHL189fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	189	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		A -> D (in a sporadic cancer; somatic mutation).|A -> G (in sporadic cancers; somatic mutation).|A -> P (in sporadic cancers; somatic mutation).|A -> S (in a sporadic cancer; somatic mutation).|A -> T (in sporadic cancers; somatic mutation).|A -> V (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q192*(83)|p.H193R(80)|p.L194R(47)|p.H193L(42)|p.H193Y(29)|p.P190L(21)|p.H193P(18)|p.L194F(17)|p.H193D(13)|p.P190fs*57(8)|p.L194P(8)|p.L194H(8)|p.0?(8)|p.?(7)|p.P191del(7)|p.P190del(6)|p.Q99*(6)|p.Q60*(6)|p.P190S(6)|p.I195fs*52(5)|p.Q192R(5)|p.L62R(5)|p.L101R(5)|p.P191delP(4)|p.H61R(4)|p.H100R(4)|p.H100L(4)|p.H61L(4)|p.A189_V197delAPPQHLIRV(4)|p.A189V(4)|p.L194L(4)|p.H193N(4)|p.P190T(4)|p.H193fs*16(3)|p.P191fs*56(3)|p.P191_E198>Q(3)|p.Q192H(3)|p.P191L(2)|p.P191fs*53(2)|p.G187fs*16(2)|p.P59delP(2)|p.H61P(2)|p.H100P(2)|p.H61D(2)|p.H100D(2)|p.P190A(2)|p.P190F(2)|p.A189G(2)|p.A189A(2)|p.L194fs*15(2)|p.P191R(2)|p.P191S(2)|p.P98delP(2)|p.H193H(2)|p.Q192Q(2)|p.P190R(2)|p.P59_E66>Q(1)|p.P191fs*57(1)|p.P190fs*19(1)|p.A189fs*19(1)|p.G187fs*64(1)|p.L188_P191del(1)|p.Q192fs*30(1)|p.P97fs*57(1)|p.I195fs*50(1)|p.L194fs*52(1)|p.P98_E105>Q(1)|p.H100Y(1)|p.H61Y(1)|p.Q192fs*16(1)|p.P58fs*>33(1)|p.P191fs*6(1)|p.H193_I195delHLI(1)|p.P191fs*15(1)|p.P191fs*18(1)|p.L62H(1)|p.A189fs*53(1)|p.A189D(1)|p.A189_Q192>E(1)|p.L194V(1)|p.L194I(1)|p.I102fs*52(1)|p.I195fs*14(1)|p.I195fs*12(1)|p.P191H(1)|p.L194fs*14(1)|p.P191P(1)|p.L101H(1)|p.P191T(1)|p.A189_P190>X(1)|p.P191_Q192delPQ(1)|p.D186_P191delDGLAPP(1)|p.Q192>XXXXXXXXX(1)|p.Q192K(1)|p.I63fs*>28(1)|p.Q192fs*56(1)|p.P190H(1)|p.Q192del(1)|p.P190P(1)|p.H193_I195>AP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCACTCGGATAAGATGCTGAGGAGGGGCCAGACCTAA	0.548		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			21	12	---	---	---	---					
NCOR1	9611	broad.mit.edu	37	17	15995180	15995180	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr17:15995180delC	ENST00000268712.3	-	22	3270	c.3013delG	c.(3013-3015)gaafs	p.E1005fs	NCOR1_ENST00000395851.1_Frame_Shift_Del_p.E1021fs|NCOR1_ENST00000395848.1_Frame_Shift_Del_p.E912fs	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	1005	Interaction with ETO.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		TACCTACCTTCCCACTCTCTG	0.443													11	74	---	---	---	---					
CD33	945	broad.mit.edu	37	19	51738484	51738484	+	Frame_Shift_Del	DEL	T	T	-			TCGA-GU-AATP-01A-11D-A391-08	TCGA-GU-AATP-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	be9a8672-1d1b-419c-a234-f7ace1feaa95	b9c564b1-03cf-47d1-96d3-bc2482fbe2aa	g.chr19:51738484delT	ENST00000436584.2	+	4	492	c.437delT	c.(436-438)cttfs	p.L146fs	CD33_ENST00000421133.2_Frame_Shift_Del_p.L146fs|CD33_ENST00000391796.3_Frame_Shift_Del_p.L273fs|CD33_ENST00000262262.4_Frame_Shift_Del_p.L273fs			P20138	CD33_HUMAN	CD33 molecule	273	Ig-like C2-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(15)|skin(1)|stomach(1)	24		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	CTGCTCGCTCTTTGTCTCTGC	0.537													41	46	---	---	---	---					
