Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SCRIB	23513	broad.mit.edu	37	8	144895083	144895083	+	Missense_Mutation	SNP	G	G	C			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr8:144895083G>C	ENST00000356994.2	-	8	697	c.691C>G	c.(691-693)Cgg>Ggg	p.R231G	SCRIB_ENST00000377533.3_Missense_Mutation_p.R150G|SCRIB_ENST00000320476.3_Missense_Mutation_p.R231G	NM_182706.4	NP_874365	Q14160	SCRIB_HUMAN	scribbled planar cell polarity protein	231	Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			TCCTCCAGCCGGTTTTCCGAC	0.682000													7	15					0	0	1	0	0
SPC25	57405	broad.mit.edu	37	2	169732593	169732593	+	Missense_Mutation	SNP	C	C	T			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr2:169732593C>T	ENST00000282074.2	-	5	581	c.440G>A	c.(439-441)cGa>cAa	p.R147Q		NM_020675.3	NP_065726.1	Q9HBM1	SPC25_HUMAN	SPC25, NDC80 kinetochore complex component	147	Interaction with the C-terminus of SPBC24.				cell division|chromosome segregation|mitotic prometaphase|mitotic spindle organization	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(3)|urinary_tract(1)	9						ATAAATTTTTCGAATTTCTAG	0.284000													3	22					0	0	1	0	0
NEK2	4751	broad.mit.edu	37	1	211844577	211844577	+	Missense_Mutation	SNP	A	A	C			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr1:211844577A>C	ENST00000366999.4	-	4	743	c.605T>G	c.(604-606)tTg>tGg	p.L202W	NEK2_ENST00000540251.1_Missense_Mutation_p.L159W|NEK2_ENST00000366998.3_Missense_Mutation_p.L202W|NEK2_ENST00000462283.1_5'UTR	NM_002497.3	NP_002488.1	P51955	NEK2_HUMAN	NIMA-related kinase 2	202	Protein kinase.				cell division|centrosome separation|G2/M transition of mitotic cell cycle|meiosis|protein autophosphorylation|regulation of mitosis	centrosome|condensed chromosome kinetochore|cytosol|nucleolus	ATP binding|metal ion binding|protein binding|protein phosphatase binding|protein serine/threonine kinase activity			breast(2)|stomach(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.00203)|all cancers(67;0.0339)|Epithelial(68;0.0546)		CAAGCAGCCCAATGACCAGAT	0.378000													12	54					0	0	1	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50659567	50659567	+	Missense_Mutation	SNP	T	T	C			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr22:50659567T>C	ENST00000439308.2	-	16	3713	c.3221A>G	c.(3220-3222)cAg>cGg	p.Q1074R	TUBGCP6_ENST00000491449.1_5'UTR|TUBGCP6_ENST00000248846.5_Missense_Mutation_p.Q1074R	NM_020461.3	NP_065194.2	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1074	9 X 27 AA tandem repeats.				G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		CCACCGTGGCTGGGTGGGAGC	0.607000													4	179					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140229589	140229589	+	Silent	SNP	G	G	A			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr5:140229589G>A	ENST00000378122.3	+	1	2233	c.1509G>A	c.(1507-1509)tcG>tcA	p.S503S	PCDHA4_ENST00000512229.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Silent_p.S503S|PCDHA8_ENST00000531613.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA4_ENST00000530339.1_Intron	NM_014005.3	NP_054724.1												p.S503S(2)		breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGAGCGCTCGCTGTCGAGCT	0.672000													27	142					0	0	1	0	0
GNA13	10672	broad.mit.edu	37	17	63010910	63010910	+	Missense_Mutation	SNP	C	C	G			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr17:63010910C>G	ENST00000439174.2	-	4	844	c.599G>C	c.(598-600)aGa>aCa	p.R200T	GNA13_ENST00000541118.1_Missense_Mutation_p.R105T	NM_006572.4	NP_006563.2	Q14344	GNA13_HUMAN	guanine nucleotide binding protein (G protein), alpha 13	200					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase D activity|cellular component movement|platelet activation|Rho protein signal transduction	brush border membrane|heterotrimeric G-protein complex|melanosome	D5 dopamine receptor binding|G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|signal transducer activity|type 1 angiotensin receptor binding	p.R200K(1)		breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(14)|kidney(2)|large_intestine(4)|lung(6)|urinary_tract(1)	34						GGTGGGTCTTCTGGCAAGCAG	0.358000													4	44					0	0	1	0	0
B4GALT2	8704	broad.mit.edu	37	1	44456007	44456007	+	Missense_Mutation	SNP	C	C	T	rs147797915		TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr1:44456007C>T	ENST00000356836.6	+	7	1796	c.1006C>T	c.(1006-1008)Cgg>Tgg	p.R336W	B4GALT2_ENST00000309519.7_Missense_Mutation_p.R365W|B4GALT2_ENST00000372324.1_Missense_Mutation_p.R336W|B4GALT2_ENST00000434555.2_Missense_Mutation_p.R270W	NM_001005417.2|NM_030587.2	NP_001005417.1|NP_085076.2	O60909	B4GT2_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2	336					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|lactose synthase activity|metal ion binding|N-acetyllactosamine synthase activity			endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	17	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			N-Acetyl-D-glucosamine(DB00141)	GACCATGAAGCGGGACGGCAT	0.498000													4	245					0	0	1	0	0
KIF1A	547	broad.mit.edu	37	2	241709104	241709104	+	Missense_Mutation	SNP	G	G	C			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr2:241709104G>C	ENST00000498729.2	-	16	1607	c.1361C>G	c.(1360-1362)gCt>gGt	p.A454G	KIF1A_ENST00000320389.7_Missense_Mutation_p.A445G	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	445					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		ATTGAGCTCAGCTATGATCTT	0.612000													10	29					0	0	1	0	0
TAF2	6873	broad.mit.edu	37	8	120816152	120816152	+	Missense_Mutation	SNP	G	G	T			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr8:120816152G>T	ENST00000378164.2	-	5	824	c.526C>A	c.(526-528)Cat>Aat	p.H176N		NM_003184.3	NP_003175	Q6P1X5	TAF2_HUMAN	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa	176					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			NS(2)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(21)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	49	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			GAGAAAACATGAGCACCTCTC	0.348000													5	166					0.217242	0.217242	1	1	0
SLC8A2	6543	broad.mit.edu	37	19	47969386	47969386	+	Missense_Mutation	SNP	C	C	T			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr19:47969386C>T	ENST00000236877.6	-	2	670	c.275G>A	c.(274-276)cGt>cAt	p.R92H	SLC8A2_ENST00000542837.1_Intron|SLC8A2_ENST00000539381.1_Intron	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	92					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		CGCCATGAAACGGTCGGCGAT	0.587000													6	106					0	0	1	0	0
NDUFAF4	29078	broad.mit.edu	37	6	97344707	97344707	+	Silent	SNP	T	T	C			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr6:97344707T>C	ENST00000316149.7	-	2	232	c.153A>G	c.(151-153)aaA>aaG	p.K51K	NDUFAF4_ENST00000489477.1_5'UTR	NM_014165.3	NP_054884.1	Q9P032	NDUF4_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 4	51					mitochondrial respiratory chain complex I assembly	mitochondrial membrane	calmodulin binding			large_intestine(5)|lung(3)|ovary(1)|skin(1)	10						CAATCTCTCCTTTAACTTCTG	0.348000													7	41					0	0	1	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025366	207025366	+	Silent	SNP	G	G	A			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr2:207025366G>A	ENST00000392222.2	+	2	510	c.135G>A	c.(133-135)ccG>ccA	p.P45P	EEF1B2_ENST00000392221.1_Silent_p.P45P|EEF1B2_ENST00000236957.5_Silent_p.P45P	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	45	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.P45P(5)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						CCAGCCCACCGCCTGCCGACT	0.448000													4	77					0	0	1	0	0
C2CD3	26005	broad.mit.edu	37	11	73809142	73809142	+	Missense_Mutation	SNP	C	C	G			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr11:73809142C>G	ENST00000334126.7	-	16	3117	c.2891G>C	c.(2890-2892)aGa>aCa	p.R964T	C2CD3_ENST00000313663.7_Missense_Mutation_p.R964T			Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	964						centrosome				NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(26)|ovary(4)|pancreas(2)|prostate(1)|skin(3)	64	Breast(11;4.16e-06)					ATTCTTTAATCTTTGTAGTGC	0.448000													7	76					0	0	1	0	0
IP6K3	117283	broad.mit.edu	37	6	33694544	33694544	+	Missense_Mutation	SNP	G	G	A			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr6:33694544G>A	ENST00000451316.1	-	5	1088	c.553C>T	c.(553-555)Cgc>Tgc	p.R185C	IP6K3_ENST00000293756.4_Missense_Mutation_p.R185C	NM_001142883.1	NP_001136355.1	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	185					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity			skin(1)	1						GAGCACAGGCGGGTCAGGTGG	0.622000													8	43					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18544155	18544155	+	Missense_Mutation	SNP	G	G	T			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr12:18544155G>T	ENST00000433979.1	+	14	2088	c.1972G>T	c.(1972-1974)Gcc>Tcc	p.A658S	PIK3C2G_ENST00000538779.1_Missense_Mutation_p.A699S|PIK3C2G_ENST00000266497.5_Missense_Mutation_p.A658S	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	658					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				AAAACATATTGCCAGACTTTC	0.388000													3	28					0.004672	0.00477699	1	1	0
ZNF540	163255	broad.mit.edu	37	19	38102883	38102883	+	Missense_Mutation	SNP	G	G	C			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr19:38102883G>C	ENST00000592533.1	+	5	1034	c.702G>C	c.(700-702)caG>caC	p.Q234H	ZNF540_ENST00000589117.1_Missense_Mutation_p.Q202H|ZNF540_ENST00000316433.4_Missense_Mutation_p.Q234H|ZNF540_ENST00000343599.5_Missense_Mutation_p.Q234H	NM_152606.4	NP_689819.1			zinc finger protein 540											breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(13)|lung(8)|skin(1)	28			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CTCTGCATCAGAGATTTCATA	0.368000													10	38					0	0	1	0	0
ADCY2	108	broad.mit.edu	37	5	7784525	7784525	+	Missense_Mutation	SNP	C	C	A			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr5:7784525C>A	ENST00000338316.4	+	19	2521	c.2432C>A	c.(2431-2433)tCt>tAt	p.S811Y	ADCY2_ENST00000537121.1_Missense_Mutation_p.S631Y	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	811					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						GTGTCTCTCTCTATATTCTTC	0.378000													6	83					0.0293803	0.0297068	1	1	0
PCDHGA6	56109	broad.mit.edu	37	5	140755394	140755394	+	Missense_Mutation	SNP	G	G	A			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr5:140755394G>A	ENST00000517434.1	+	1	1744	c.1744G>A	c.(1744-1746)Gca>Aca	p.A582T	PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018919.2|NM_032086.1	NP_061742.1|NP_114475.1														breast(1)|large_intestine(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCCCGCTCCGCAGAGCCCGG	0.672000													22	133					0	0	1	0	0
ABR	29	broad.mit.edu	37	17	961237	961237	+	Missense_Mutation	SNP	C	C	G			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr17:961237C>G	ENST00000544583.2	-	12	1815	c.1216G>C	c.(1216-1218)Gaa>Caa	p.E406Q	ABR_ENST00000574437.1_Missense_Mutation_p.E406Q|ABR_ENST00000302538.5_Missense_Mutation_p.E452Q|ABR_ENST00000291107.2_Missense_Mutation_p.E415Q|ABR_ENST00000536794.2_Missense_Mutation_p.E234Q|ABR_ENST00000573895.1_5'UTR	NM_001159746.2	NP_001153218.1	Q12979	ABR_HUMAN	active BCR-related	452	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		TGAATTGCTTCTCTCCACTCT	0.478000													5	58					0	0	1	0	0
ANKHD1	54882	broad.mit.edu	37	5	139908519	139908519	+	Silent	SNP	C	C	T			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr5:139908519C>T	ENST00000297183.6	+	29	6112	c.5988C>T	c.(5986-5988)agC>agT	p.S1996S	ANKHD1_ENST00000544120.1_Silent_p.S379S|ANKHD1_ENST00000360839.2_Silent_p.S1996S|ANKHD1-EIF4EBP3_ENST00000532219.1_Silent_p.S1996S	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTATCACTAGCGGGCAAGCTC	0.493000													24	105					0	0	1	0	0
MAP3K4	4216	broad.mit.edu	37	6	161491786	161491786	+	Silent	SNP	T	T	G			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr6:161491786T>G	ENST00000392142.4	+	4	2002	c.1854T>G	c.(1852-1854)gtT>gtG	p.V618V	MAP3K4_ENST00000348824.7_Silent_p.V618V|MAP3K4_ENST00000366919.2_Silent_p.V618V|MAP3K4_ENST00000366920.2_Silent_p.V618V	NM_005922.2	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	618					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(28)|ovary(3)|skin(2)|stomach(1)	77		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		CCTTCCTAGTTCTCTGCCGAG	0.478000													3	30					0	0	1	0	0
CHL1	10752	broad.mit.edu	37	3	430987	430987	+	Nonsense_Mutation	SNP	G	G	A			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr3:430987G>A	ENST00000256509.2	+	20	2942	c.2300G>A	c.(2299-2301)tGg>tAg	p.W767*	CHL1_ENST00000397491.2_Nonsense_Mutation_p.W751*	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	751	Fibronectin type-III 2.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		agagtgacctggaAGCCACAG	0.498000													3	19					0	0	1	0	0
ERI1	90459	broad.mit.edu	37	8	8865558	8865558	+	Missense_Mutation	SNP	G	G	A			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr8:8865558G>A	ENST00000523898.1	+	3	866	c.187G>A	c.(187-189)Gac>Aac	p.D63N	ERI1_ENST00000250263.7_Missense_Mutation_p.D63N|ERI1_ENST00000519292.1_Missense_Mutation_p.D63N			Q8IV48	ERI1_HUMAN	exoribonuclease 1	63					gene silencing by RNA|rRNA 3'-end processing	cytoplasm|histone pre-mRNA 3'end processing complex|nucleolus	3'-5' exonuclease activity|histone pre-mRNA stem-loop binding|metal ion binding|ribosome binding|rRNA binding			NS(1)|endometrium(2)|large_intestine(1)|lung(6)|prostate(1)	11					Adenosine monophosphate(DB00131)	TGACTTCAGTGACCCGGTTTA	0.378000													5	55					0	0	1	0	0
GAD2	2572	broad.mit.edu	37	10	26534903	26534903	+	Silent	SNP	C	C	T			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr10:26534903C>T	ENST00000376261.3	+	8	1397	c.894C>T	c.(892-894)agC>agT	p.S298S	GAD2_ENST00000259271.3_Silent_p.S298S	NM_001134366.1	NP_001127838.1	Q05329	DCE2_HUMAN	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	298					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(26)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	48					L-Glutamic Acid(DB00142)	GAACAGACAGCGTGATTCTGA	0.388000													3	43					0	0	1	0	0
MIA3	375056	broad.mit.edu	37	1	222802358	222802358	+	Missense_Mutation	SNP	C	C	G			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr1:222802358C>G	ENST00000344922.5	+	4	1821	c.1796C>G	c.(1795-1797)gCt>gGt	p.A599G	MIA3_ENST00000344507.1_Intron|MIA3_ENST00000470521.1_3'UTR|MIA3_ENST00000344441.6_Missense_Mutation_p.A599G	NM_198551.2	NP_940953.2	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	599					exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(5)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(15)|lung(37)|ovary(5)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|urinary_tract(1)	80				GBM - Glioblastoma multiforme(131;0.0199)		GAGGGAGACGCTTTGGTAAAT	0.463000													10	85					0	0	1	0	0
HMHB1	57824	broad.mit.edu	37	5	143200100	143200100	+	Silent	SNP	G	G	C			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr5:143200100G>C	ENST00000289448.2	+	2	200	c.93G>C	c.(91-93)ctG>ctC	p.L31L	CTB-57H20.1_ENST00000503323.1_RNA	NM_021182.1	NP_067005	O97980	HMHB1_HUMAN	histocompatibility (minor) HB-1	31													Acute lymphoblastic leukemia(2;0.0236)|all_hematologic(2;0.041)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			ATGTGTATCTGAGGCACAGCT	0.448000													22	112					0	0	1	0	0
TYRO3	7301	broad.mit.edu	37	15	41856423	41856423	+	Missense_Mutation	SNP	C	C	A			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr15:41856423C>A	ENST00000263798.3	+	5	846	c.622C>A	c.(622-624)Cta>Ata	p.L208I	TYRO3_ENST00000559066.1_Missense_Mutation_p.L163I	NM_006293.3	NP_006284.2	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase	208	Ig-like C2-type 2.					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(26)|ovary(3)|prostate(1)	43		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		AGCTCACAACCTAAAAGGCCT	0.602000													7	96					5.18039e-06	5.41857e-06	1	1	0
SGPL1	8879	broad.mit.edu	37	10	72631732	72631732	+	Missense_Mutation	SNP	G	G	A			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr10:72631732G>A	ENST00000373202.3	+	11	1248	c.1048G>A	c.(1048-1050)Gac>Aac	p.D350N		NM_003901.3	NP_003892.2	O95470	SGPL1_HUMAN	sphingosine-1-phosphate lyase 1	350					apoptosis|carboxylic acid metabolic process|ceramide metabolic process|sphingolipid catabolic process	integral to endoplasmic reticulum membrane	carboxy-lyase activity|pyridoxal phosphate binding|sphinganine-1-phosphate aldolase activity			large_intestine(4)	4					Pyridoxal Phosphate(DB00114)	CATTTCAGCTGACACCCATAA	0.423000													5	74					0	0	1	0	0
HERC2P3	283755	broad.mit.edu	37	15	20644850	20644850	+	RNA	SNP	G	G	A			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr15:20644850G>A	ENST00000428453.1	-	0	3097																		p.A803V(4)		central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						CATGTCCCTCGCCCTTTCGGT	0.463000													4	47					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135429265	135429265	+	Missense_Mutation	SNP	G	G	A			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chrX:135429265G>A	ENST00000394143.1	+	6	3691	c.3400G>A	c.(3400-3402)Gat>Aat	p.D1134N	GPR112_ENST00000370652.1_Missense_Mutation_p.D1134N|GPR112_ENST00000412101.1_Missense_Mutation_p.D929N|GPR112_ENST00000287534.4_Missense_Mutation_p.D1071N|GPR112_ENST00000394141.1_Missense_Mutation_p.D929N	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1134					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TACCTCAGTTGATACAGTAAC	0.488000													15	43					0	0	1	0	0
GDA	9615	broad.mit.edu	37	9	74842873	74842873	+	Silent	SNP	C	C	T			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr9:74842873C>T	ENST00000358399.3	+	9	930	c.837C>T	c.(835-837)caC>caT	p.H279H	GDA_ENST00000477618.1_3'UTR|GDA_ENST00000545168.1_Silent_p.H205H|GDA_ENST00000376989.3_Silent_p.H218H|GDA_ENST00000238018.4_Silent_p.H279H|GDA_ENST00000376986.1_Silent_p.H201H	NM_001242505.2|NM_001242506.2|NM_004293.4	NP_001229434.1|NP_001229435.1|NP_004284.1	Q9Y2T3	GUAD_HUMAN	guanine deaminase	279					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(1)|lung(20)|ovary(2)|skin(2)|urinary_tract(1)	32		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		TGATGGCACACGGCTGCTACC	0.458000													4	31					0	0	1	0	0
TYRP1	7306	broad.mit.edu	37	9	12695751	12695751	+	Translation_Start_Site	SNP	T	T	A			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr9:12695751T>A	ENST00000381137.2	+	0	800				TYRP1_ENST00000381136.2_De_novo_Start_OutOfFrame|TYRP1_ENST00000388918.5_Missense_Mutation_p.F208I			P17643	TYRP1_HUMAN	tyrosinase-related protein 1						melanin biosynthetic process	clathrin-coated endocytic vesicle membrane|endosome membrane|integral to membrane|melanosome membrane	copper ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen|protein heterodimerization activity|protein homodimerization activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|stomach(1)	22		all_cancers(3;3.1e-05)|all_lung(3;1.7e-06)|Lung NSC(3;2.09e-06)|all_epithelial(3;0.000695)|all_hematologic(3;0.0033)|Acute lymphoblastic leukemia(23;0.0744)		GBM - Glioblastoma multiforme(50;9.85e-06)		ACAGGAAAGCTTTGGTGAAGT	0.438000									Oculocutaneous Albinism				5	55					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10944669	10944669	+	Splice_Site	SNP	T	T	C			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr21:10944669T>C	ENST00000298232.7	-	10	878	c.511A>G	c.(511-513)Aga>Gga	p.R171G	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Splice_Site_p.R151G|TPTE_ENST00000361285.4_Splice_Site_p.R189G	NM_199259.2	NP_954868	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	189					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTTTCATACCTGGGAATATTC	0.289000													17	231					0	0	1	0	0
UBB	7314	broad.mit.edu	37	17	16285560	16285560	+	Silent	SNP	T	T	C			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr17:16285560T>C	ENST00000302182.3	+	2	731	c.339T>C	c.(337-339)ccT>ccC	p.P113P	UBB_ENST00000578649.1_Intron|RP11-138I1.4_ENST00000583934.1_RNA|UBB_ENST00000395839.1_Silent_p.P113P|UBB_ENST00000395837.1_Silent_p.P113P|UBB_ENST00000535788.1_Intron	NM_001281720.1|NM_018955.3	NP_001268649.1|NP_061828.1	P0CG47	UBB_HUMAN	ubiquitin B	113	Ubiquitin-like 2.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		AAGGCATCCCTCCCGACCAGC	0.557000													4	101					0	0	1	0	0
ZBTB46	140685	broad.mit.edu	37	20	62407302	62407302	+	Silent	SNP	G	G	A			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr20:62407302G>A	ENST00000245663.4	-	3	1101	c.951C>T	c.(949-951)tcC>tcT	p.S317S	ZBTB46_ENST00000302995.2_Silent_p.S317S|ZBTB46_ENST00000395104.1_Silent_p.S317S	NM_025224.3	NP_079500.2	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	317					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					CTTCGGTGACGGACAGGTCCG	0.617000													4	52					0	0	1	0	0
KRT28	162605	broad.mit.edu	37	17	38950178	38950178	+	Missense_Mutation	SNP	C	C	T			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr17:38950178C>T	ENST00000306658.7	-	6	1164	c.1099G>A	c.(1099-1101)Gag>Aag	p.E367K		NM_181535.3	NP_853513.2	Q7Z3Y7	K1C28_HUMAN	keratin 28	367	Coil 2.|Rod.					cytoplasm|intermediate filament	structural molecule activity			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30		Breast(137;0.000301)				TTCTGGCCCTCGGTCTCGGTT	0.552000													16	131					0	0	1	0	0
FGFR2	2263	broad.mit.edu	37	10	123239508	123239508	+	Missense_Mutation	SNP	C	C	T			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr10:123239508C>T	ENST00000358487.5	-	18	2601	c.2329G>A	c.(2329-2331)Gaa>Aaa	p.E777K	FGFR2_ENST00000357555.5_Intron|FGFR2_ENST00000369061.4_Missense_Mutation_p.E665K|FGFR2_ENST00000478859.1_Missense_Mutation_p.E549K|FGFR2_ENST00000346997.2_Missense_Mutation_p.E775K|FGFR2_ENST00000369060.4_Missense_Mutation_p.E661K|FGFR2_ENST00000356226.4_Missense_Mutation_p.E660K|FGFR2_ENST00000369059.1_Missense_Mutation_p.E663K|FGFR2_ENST00000457416.2_Missense_Mutation_p.E778K	NM_000141.4	NP_000132.3	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2	777					angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding	p.E777K(1)|p.E778*(1)		breast(3)|central_nervous_system(3)|cervix(2)|endometrium(98)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|lung(21)|ovary(4)|skin(30)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(2)	181		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	GAATACTGTTCGAGAGGTTGG	0.453000		5	Mis		"""gastric. NSCLC, endometrial"""		"""Crouzon, Pfeiffer, and Apert syndromes"""		Saethre-Chotzen syndrome;Apert syndrome				11	109					0	0	1	0	0
OR4C46	119749	broad.mit.edu	37	11	51515722	51515722	+	Nonsense_Mutation	SNP	G	G	A			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr11:51515722G>A	ENST00000328188.1	+	1	441	c.441G>A	c.(439-441)tgG>tgA	p.W147*		NM_001004703.1	NP_001004703.1	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C, member 46	147					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(5)|large_intestine(5)|lung(31)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	48						GAGTGGTGTGGATGGGAGGCT	0.463000													19	86					0	0	1	0	0
OR4K14	122740	broad.mit.edu	37	14	20482734	20482734	+	Missense_Mutation	SNP	G	G	T			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr14:20482734G>T	ENST00000305045.2	-	1	618	c.619C>A	c.(619-621)Ctt>Att	p.L207I		NM_001004712.1	NP_001004712.1	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K, member 14	207					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(20)|skin(6)	37	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		CTCAAGGAAAGCAACCCACTG	0.507000													3	25					0.004672	0.00477699	1	1	0
KRTAP21-1	337977	broad.mit.edu	37	21	32127620	32127620	+	Missense_Mutation	SNP	C	C	T			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr21:32127620C>T	ENST00000335093.3	-	1	126	c.77G>A	c.(76-78)tGt>tAt	p.C26Y		NM_181619.1	NP_853650.1	Q3LI58	KR211_HUMAN	keratin associated protein 21-1	26						intermediate filament				breast(1)|endometrium(1)|lung(4)|urinary_tract(1)	7						gccacagccacagccagagcc	0.542000													4	103					0	0	1	0	0
FBXO40	51725	broad.mit.edu	37	3	121341630	121341630	+	Missense_Mutation	SNP	C	C	T			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr3:121341630C>T	ENST00000338040.4	+	3	1768	c.1354C>T	c.(1354-1356)Cca>Tca	p.P452S		NM_016298.3	NP_057382.2	Q9UH90	FBX40_HUMAN	F-box protein 40	452					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(11)|lung(19)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	46				GBM - Glioblastoma multiforme(114;0.189)		CGCTGCCACCCCAGGGGGACT	0.512000													9	57					0	0	1	0	0
BIRC3	330	broad.mit.edu	37	11	102207769	102207769	+	Missense_Mutation	SNP	C	C	G			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr11:102207769C>G	ENST00000263464.3	+	9	4501	c.1751C>G	c.(1750-1752)tCt>tGt	p.S584C	BIRC3_ENST00000532808.1_Missense_Mutation_p.S584C	NM_001165.4	NP_001156.1	Q13489	BIRC3_HUMAN	baculoviral IAP repeat containing 3	584					anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(7)|lung(5)|ovary(3)|skin(1)	21	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0146)		TGTGCTCCTTCTTTAAGAAAG	0.348000			T	MALT1	MALT								3	36					0	0	1	0	0
SPAG5	10615	broad.mit.edu	37	17	26919030	26919030	+	Missense_Mutation	SNP	C	C	G			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr17:26919030C>G	ENST00000321765.5	-	3	1564	c.1232G>C	c.(1231-1233)aGt>aCt	p.S411T		NM_006461.3	NP_006452.3	Q96R06	SPAG5_HUMAN	sperm associated antigen 5	411					cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	43	Lung NSC(42;0.00431)					CTCAGAAGTACTGTGCTTGGT	0.552000													5	34					0	0	1	0	0
CYP4Z2P	163720	broad.mit.edu	37	1	47325347	47325347	+	RNA	SNP	C	C	G			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr1:47325347C>G	ENST00000505841.1	-	0	1182					NR_002788.2																						GAGCGTCCATCTGGAAAGGTA	0.428000													11	89					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29628263	29628263	+	Missense_Mutation	SNP	A	A	G			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr20:29628263A>G	ENST00000278882.3	+	6	645	c.265A>G	c.(265-267)Att>Gtt	p.I89V	FRG1B_ENST00000358464.4_Missense_Mutation_p.I89V|FRG1B_ENST00000439954.2_Missense_Mutation_p.I94V														p.I89V(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TAGCTGCTTTATTAGATGCAA	0.363000													4	84					0	0	1	0	0
CYP4Z2P	163720	broad.mit.edu	37	1	47325450	47325450	+	RNA	SNP	C	C	T			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr1:47325450C>T	ENST00000505841.1	-	0	1079					NR_002788.2																						GCATCTGGCTCAGGTGTTCCC	0.498000													6	46					0	0	1	0	0
UNK	85451	broad.mit.edu	37	17	73814729	73814729	+	Silent	SNP	C	C	T			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr17:73814729C>T	ENST00000293218.3	+	12	1606	c.1606C>T	c.(1606-1608)Ctg>Ttg	p.L536L	UNK_ENST00000589666.1_Silent_p.L460L			Q9C0B0	UNK_HUMAN	unkempt family zinc finger	460							nucleic acid binding|zinc ion binding			cervix(3)|endometrium(8)|kidney(2)|large_intestine(5)|lung(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	25			all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCAGGACATGCTGGGCATCCT	0.632000													3	38					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr9:20414343A>G	ENST00000380338.4	-	5	787	c.501T>C	c.(499-501)agT>agC	p.S167S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S164S|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.532000			T	MLL	ALL								4	59					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40049239	40049239	+	Silent	SNP	T	T	A			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr20:40049239T>A	ENST00000373233.3	-	31	6213	c.6036A>T	c.(6034-6036)acA>acT	p.T2012T		NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2012					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				CAAGAGGATATGTGGGGAAAA	0.408000													19	54					0	0	1	0	0
BCL11A	53335	broad.mit.edu	37	2	60688739	60688739	+	Silent	SNP	G	G	C	rs142120696	byFrequency	TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr2:60688739G>C	ENST00000335712.6	-	4	1535	c.1308C>G	c.(1306-1308)gtC>gtG	p.V436V	BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000537768.1_Silent_p.V105V|BCL11A_ENST00000359629.5_Intron|BCL11A_ENST00000538214.1_Silent_p.V402V|BCL11A_ENST00000358510.4_Silent_p.V402V|BCL11A_ENST00000356842.4_Silent_p.V436V	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	436					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			CGTCGGACTTGACCGTCATGG	0.647000			T	IGH@	B-CLL								5	71					0	0	1	0	0
HKDC1	80201	broad.mit.edu	37	10	71026409	71026409	+	Nonsense_Mutation	SNP	C	C	T			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr10:71026409C>T	ENST00000354624.5	+	18	2783	c.2650C>T	c.(2650-2652)Cga>Tga	p.R884*	RP11-227H15.5_ENST00000413220.1_RNA	NM_025130.3	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	884					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						ACTAGCCCCTCGATGTGATGT	0.443000													9	119					0	0	1	0	0
FAM83C	128876	broad.mit.edu	37	20	33874648	33874648	+	Missense_Mutation	SNP	C	C	T			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr20:33874648C>T	ENST00000374408.3	-	4	2030	c.1934G>A	c.(1933-1935)cGt>cAt	p.R645H		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	645			R -> C (in dbSNP:rs35518957).							central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CCCCTCACCACGGAATGGGCC	0.647000													7	30					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158641928	158641928	+	Missense_Mutation	SNP	C	C	T			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr1:158641928C>T	ENST00000368147.4	-	11	1589	c.1409G>A	c.(1408-1410)cGt>cAt	p.R470H		NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)						actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CTCATACTGACGATGACGCTC	0.453000													3	54					0	0	1	0	0
RNF185	91445	broad.mit.edu	37	22	31592944	31592944	+	Missense_Mutation	SNP	C	C	G			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr22:31592944C>G	ENST00000326132.6	+	5	490	c.331C>G	c.(331-333)Caa>Gaa	p.Q111E	RNF185_ENST00000266252.7_Intron|RNF185_ENST00000426256.2_Missense_Mutation_p.Q49E	NM_152267.3	NP_689480.2	Q96GF1	RN185_HUMAN	ring finger protein 185							integral to membrane	zinc ion binding			NS(1)|large_intestine(1)|lung(3)|skin(1)	6						TCCTCGTCCTCAAGGACAGAG	0.458000													5	31					0	0	1	0	0
PRSS1	5644	broad.mit.edu	37	7	142460811	142460811	+	Silent	SNP	C	C	T			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr7:142460811C>T	ENST00000486171.1	+	6	743	c.726C>T	c.(724-726)gtC>gtT	p.V242V	PRSS1_ENST00000311737.7_Silent_p.V228V			P07477	TRY1_HUMAN	protease, serine, 1 (trypsin 1)	228	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(24)|prostate(2)	38	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			AGCCTGGAGTCTACACCAAGG	0.502000													4	105					0	0	1	0	0
MAP3K4	4216	broad.mit.edu	37	6	161491787	161491787	+	Missense_Mutation	SNP	C	C	T			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr6:161491787C>T	ENST00000392142.4	+	4	2003	c.1855C>T	c.(1855-1857)Ctc>Ttc	p.L619F	MAP3K4_ENST00000348824.7_Missense_Mutation_p.L619F|MAP3K4_ENST00000366919.2_Missense_Mutation_p.L619F|MAP3K4_ENST00000366920.2_Missense_Mutation_p.L619F	NM_005922.2	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	619					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(28)|ovary(3)|skin(2)|stomach(1)	77		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		CTTCCTAGTTCTCTGCCGAGT	0.483000													3	30					0	0	1	0	0
CRYBB2	1415	broad.mit.edu	37	22	25623911	25623911	+	Nonsense_Mutation	SNP	C	C	T			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr22:25623911C>T	ENST00000398215.2	+	4	436	c.265C>T	c.(265-267)Cga>Tga	p.R89*		NM_000496.2	NP_000487.1	P43320	CRBB2_HUMAN	crystallin, beta B2	89	Beta/gamma crystallin 'Greek key' 2.				response to stimulus|visual perception		structural constituent of eye lens			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)	10						GACCAGCAGCCGAAGGACGGA	0.597000													10	65					0	0	1	0	0
SYNJ1	8867	broad.mit.edu	37	21	34004012	34004012	+	Nonsense_Mutation	SNP	G	G	A			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr21:34004012G>A	ENST00000382491.3	-	28	3998	c.3874C>T	c.(3874-3876)Cag>Tag	p.Q1292*	SYNJ1_ENST00000357345.3_3'UTR|SYNJ1_ENST00000322229.7_Nonsense_Mutation_p.Q1339*|SYNJ1_ENST00000382499.2_3'UTR|SYNJ1_ENST00000433931.2_Nonsense_Mutation_p.Q1378*	NM_001160306.1	NP_001153778.1	O43426	SYNJ1_HUMAN	synaptojanin 1	1339	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						ACAGATAGCTGAGCCTTTGAT	0.408000													3	51					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71747336	71747336	+	Missense_Mutation	SNP	C	C	T			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr2:71747336C>T	ENST00000258104.3	+	10	1212	c.935C>T	c.(934-936)cCc>cTc	p.P312L	DYSF_ENST00000429174.2_Missense_Mutation_p.P312L|DYSF_ENST00000410041.1_Missense_Mutation_p.P344L|DYSF_ENST00000413539.2_Missense_Mutation_p.P343L|DYSF_ENST00000409744.1_Missense_Mutation_p.P313L|DYSF_ENST00000409582.3_Missense_Mutation_p.P343L|DYSF_ENST00000409762.1_Missense_Mutation_p.P343L|DYSF_ENST00000410020.3_Missense_Mutation_p.P344L|DYSF_ENST00000394120.2_Missense_Mutation_p.P313L|DYSF_ENST00000409651.1_Missense_Mutation_p.P344L|DYSF_ENST00000409366.1_Missense_Mutation_p.P313L	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	312						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						TACAGAGAGCCCCGTGAGTTC	0.493000													23	96					0	0	1	0	0
RHOBTB1	9886	broad.mit.edu	37	10	62645942	62645942	+	Silent	SNP	C	C	T			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr10:62645942C>T	ENST00000337910.5	-	7	1840	c.1503G>A	c.(1501-1503)ccG>ccA	p.P501P	RHOBTB1_ENST00000357917.4_Silent_p.P501P	NM_001242359.1|NM_014836.4	NP_001229288.1|NP_055651.1	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	501	BTB 2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	Prostate(12;0.0112)					AGATCAGCAGCGGCTTGTGGG	0.507000													6	75					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219894869	219894869	+	Missense_Mutation	SNP	G	G	A			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr2:219894869G>A	ENST00000341552.5	-	10	1306	c.1223C>T	c.(1222-1224)tCa>tTa	p.S408L	CCDC108_ENST00000409865.3_Missense_Mutation_p.S397L|CCDC108_ENST00000453220.1_Missense_Mutation_p.S408L|CCDC108_ENST00000410037.1_Missense_Mutation_p.S343L|CCDC108_ENST00000441968.1_Missense_Mutation_p.S408L	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	408						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CGTGGGGCATGAGAAGGCCTG	0.557000											OREG0015211	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	88					0	0	1	0	0
SOCS6	9306	broad.mit.edu	37	18	67993149	67993149	+	Silent	SNP	T	T	C			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr18:67993149T>C	ENST00000397942.3	+	2	1561	c.1245T>C	c.(1243-1245)cgT>cgC	p.R415R	SOCS6_ENST00000582322.1_Silent_p.R415R	NM_004232.3	NP_004223.2	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	415	SH2.				defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm				NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)	22		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				CTGACGACCGTTACCTTTTAA	0.468000													8	61					0	0	1	0	0
NAA50	80218	broad.mit.edu	37	3	113440614	113440614	+	Missense_Mutation	SNP	T	T	C			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr3:113440614T>C	ENST00000240922.3	-	5	827	c.503A>G	c.(502-504)gAc>gGc	p.D168G	NAA50_ENST00000477813.1_Missense_Mutation_p.D128G|NAA50_ENST00000493454.1_Missense_Mutation_p.D94G|NAA50_ENST00000493900.1_Missense_Mutation_p.D167G|NAA50_ENST00000497255.1_Missense_Mutation_p.D57G|NAA50_ENST00000497525.1_Missense_Mutation_p.D94G	NM_025146.2	NP_079422.1	Q9GZZ1	NAA50_HUMAN	N(alpha)-acetyltransferase 50, NatE catalytic subunit						N-terminal protein amino acid acetylation	cytoplasm	N-acetyltransferase activity|protein binding			large_intestine(2)|lung(2)|skin(1)	5						TGTTCAGTTGTCTGTCTTTTG	0.418000													27	83					0	0	1	0	0
FAM124A	220108	broad.mit.edu	37	13	51825659	51825659	+	Silent	SNP	C	C	T			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr13:51825659C>T	ENST00000322475.8	+	3	291	c.156C>T	c.(154-156)atC>atT	p.I52I	FAM124A_ENST00000280057.6_Silent_p.I88I	NM_001242312.1	NP_001229241.1	Q86V42	F124A_HUMAN	family with sequence similarity 124A	52										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|skin(1)	26		Acute lymphoblastic leukemia(7;0.000334)|Breast(56;0.00156)|Prostate(109;0.00538)|Lung NSC(96;0.0216)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;4.25e-07)		TCCACATAATCGCAGACCCAG	0.592000													6	36					0	0	1	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025358	207025358	+	Missense_Mutation	SNP	A	A	G			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr2:207025358A>G	ENST00000392222.2	+	2	502	c.127A>G	c.(127-129)Agc>Ggc	p.S43G	EEF1B2_ENST00000392221.1_Missense_Mutation_p.S43G|EEF1B2_ENST00000236957.5_Missense_Mutation_p.S43G	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	43	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.S43G(4)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						AGCCGTGTCCAGCCCACCGCC	0.468000													4	70					0	0	1	0	0
FAM131B	9715	broad.mit.edu	37	7	143056071	143056071	+	Missense_Mutation	SNP	C	C	T			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr7:143056071C>T	ENST00000409408.1	-	4	1939	c.231G>A	c.(229-231)atG>atA	p.M77I	FAM131B_ENST00000409578.1_Missense_Mutation_p.M93I|FAM131B_ENST00000409222.3_Missense_Mutation_p.M77I|FAM131B_ENST00000443739.2_Missense_Mutation_p.M105I|FAM131B_ENST00000409346.1_Missense_Mutation_p.M77I			Q86XD5	F131B_HUMAN	family with sequence similarity 131, member B	77										breast(1)|endometrium(4)|large_intestine(3)|lung(13)|ovary(1)|skin(2)	24	Melanoma(164;0.205)					GGCCTTGCCCCATGGCTGTGG	0.572000													7	30					0	0	1	0	0
MICALL1	85377	broad.mit.edu	37	22	38323565	38323565	+	Nonsense_Mutation	SNP	C	C	G			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr22:38323565C>G	ENST00000215957.6	+	9	1739	c.1613C>G	c.(1612-1614)tCa>tGa	p.S538*	MICALL1_ENST00000402631.1_3'UTR	NM_033386.3	NP_203744.1	Q8N3F8	MILK1_HUMAN	MICAL-like 1	538	Pro-rich.					cytoplasm|cytoskeleton	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	24	Melanoma(58;0.045)					AAGAGCTCCTCAGAGCCTGCT	0.637000													11	79					0	0	1	0	0
LRRC40	55631	broad.mit.edu	37	1	70614211	70614211	+	Silent	SNP	G	G	C			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr1:70614211G>C	ENST00000370952.3	-	14	1741	c.1662C>G	c.(1660-1662)ctC>ctG	p.L554L		NM_017768.4	NP_060238.3	Q9H9A6	LRC40_HUMAN	leucine rich repeat containing 40	554										breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|skin(2)	27						GAATTTGTAAGAGGTCATTAT	0.343000													16	84					0	0	1	0	0
GPR179	440435	broad.mit.edu	37	17	36483325	36483325	+	Missense_Mutation	SNP	C	C	G			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr17:36483325C>G	ENST00000342292.4	-	11	6147	c.6127G>C	c.(6127-6129)Gaa>Caa	p.E2043Q	GPR179_ENST00000584976.1_Intron	NM_001004334.2	NP_001004334.2	Q6PRD1	GP179_HUMAN	G protein-coupled receptor 179	2043						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(4)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(16)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				CCTTTCTCTTCTTGAGAGTCC	0.527000													14	74					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713407	142713407	+	RNA	SNP	C	C	T	rs142431664	by1000genomes	TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr1:142713407C>T	ENST00000610091.1	-	0	2251																											CAGTAAGAAACTCATTCTTAT	0.318000													4	26					0	0	1	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74575197	74575197	+	Missense_Mutation	SNP	T	T	C			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr1:74575197T>C	ENST00000354431.4	-	5	939	c.748A>G	c.(748-750)Att>Gtt	p.I250V	LRRIQ3_ENST00000395089.1_Missense_Mutation_p.I250V|LRRIQ3_ENST00000370909.2_Missense_Mutation_p.I142V|LRRIQ3_ENST00000468759.1_5'UTR	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	250				QQEKII -> TAGKNY (in Ref. 1; BAD18621).						NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						TATCCTCTAATAATTTTTTCC	0.308000													11	46					0	0	1	0	0
BRD7	29117	broad.mit.edu	37	16	50354263	50354263	+	Missense_Mutation	SNP	C	C	G			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr16:50354263C>G	ENST00000394688.3	-	15	1811	c.1652G>C	c.(1651-1653)aGa>aCa	p.R551T	BRD7_ENST00000394689.2_Missense_Mutation_p.R552T			Q9NPI1	BRD7_HUMAN	bromodomain containing 7	551					cell cycle|negative regulation of cell proliferation|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of histone acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleus	histone acetyl-lysine binding|p53 binding|transcription coactivator activity|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|prostate(2)|urinary_tract(2)	22		all_cancers(37;0.0127)				CCTGAGCAATCTGGTGGTCTC	0.463000													8	67					0	0	1	0	0
MCEE	84693	broad.mit.edu	37	2	71351605	71351605	+	Nonsense_Mutation	SNP	G	G	A			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr2:71351605G>A	ENST00000244217.5	-	2	126	c.109C>T	c.(109-111)Caa>Taa	p.Q37*		NM_032601.3	NP_115990.3	Q96PE7	MCEE_HUMAN	methylmalonyl CoA epimerase	37					fatty acid beta-oxidation|L-methylmalonyl-CoA metabolic process	mitochondrial matrix	methylmalonyl-CoA epimerase activity			kidney(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9						CCTGTCACTTGATCCAAGGGC	0.448000													10	132					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151166340	151166340	+	Missense_Mutation	SNP	T	T	A			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr3:151166340T>A	ENST00000282466.3	-	4	1428	c.1429A>T	c.(1429-1431)Agg>Tgg	p.R477W		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	477	Ig-like C2-type 1.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TTGTTATCCCTTGAAATCATA	0.478000													10	111					0	0	1	0	0
TMEM259	91304	broad.mit.edu	37	19	1010796	1010796	+	Frame_Shift_Del	DEL	G	G	-			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr19:1010796delG	ENST00000356663.3	-	11	1537	c.1416delC	c.(1414-1416)cccfs	p.P472fs	TMEM259_ENST00000333175.5_3'UTR	NM_001033026.1	NP_001028198.1			transmembrane protein 259																		TGGGGGTCCCGGGGCCCAGTG	0.677													2	4	---	---	---	---					
LA16c-23H5.4	0	broad.mit.edu	37	22	16419352	16419352	+	RNA	DEL	T	T	-			TCGA-SY-A9G0-01A-12D-A38G-08	TCGA-SY-A9G0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	96624006-b7b9-4f04-b31d-8132ea22f7e9	923f6353-020c-437c-961f-dfbe7516bfe4	g.chr22:16419352delT	ENST00000444162.1	+	0	279																											GAATCGACGATTTTTTTTTTG	0.398													3	3	---	---	---	---					
