Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FUNDC2P2	388965	broad.mit.edu	37	2	84518335	84518335	+	RNA	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:84518335G>A	ENST00000331369.5	+	0	529																											TGTCATTTGTGAAGAAAAATG	0.448000													29	109					0	0	1	0	0
SNRPB	6628	broad.mit.edu	37	20	2443305	2443305	+	Missense_Mutation	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr20:2443305C>T	ENST00000339610.6	-	7	880	c.425G>A	c.(424-426)cGg>cAg	p.R142Q	SNRPB_ENST00000381342.2_Missense_Mutation_p.R221Q|SNRPB_ENST00000438552.2_Missense_Mutation_p.R221Q			P14678	RSMB_HUMAN	small nuclear ribonucleoprotein polypeptides B and B1	221					histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|RNA binding			kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	10						GGGAGGAGGCCGCATTCCCGG	0.587000													15	55					0	0	1	0	0
OR10P1	121130	broad.mit.edu	37	12	56030771	56030771	+	Silent	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:56030771T>C	ENST00000309675.2	+	1	128	c.96T>C	c.(94-96)ctT>ctC	p.L32L		NM_206899.1	NP_996782.1	Q8NGE3	O10P1_HUMAN	olfactory receptor, family 10, subfamily P, member 1	32					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26						GGGTGGTGCTTCTGGTCTACC	0.577000													32	37					0	0	1	0	0
IGF2BP2	10644	broad.mit.edu	37	3	185407296	185407296	+	Missense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:185407296G>A	ENST00000382199.2	-	6	619	c.524C>T	c.(523-525)tCt>tTt	p.S175F	IGF2BP2_ENST00000421047.2_Missense_Mutation_p.S118F|IGF2BP2_ENST00000346192.3_Missense_Mutation_p.S175F|IGF2BP2_ENST00000457616.2_Missense_Mutation_p.S181F	NM_006548.4	NP_006539.3	Q9Y6M1	IF2B2_HUMAN	insulin-like growth factor 2 mRNA binding protein 2	175					anatomical structure morphogenesis|negative regulation of translation	cytoskeletal part|cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)	20	all_cancers(143;5.84e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			CTCCCGGGAAGAGTGGTCCCC	0.607000													27	50					0	0	1	0	0
TRPM1	4308	broad.mit.edu	37	15	31320534	31320534	+	Splice_Site	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr15:31320534C>G	ENST00000542188.1	-	24	3658		c.e24+1		TRPM1_ENST00000256552.6_Splice_Site|TRPM1_ENST00000397795.2_Splice_Site|RP11-348B17.1_ENST00000561299.1_RNA|RP11-348B17.1_ENST00000558755.1_RNA	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1						cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		GTGACACGTACTTGAACACAG	0.473000													15	39					0	0	1	0	0
PIP4K2C	79837	broad.mit.edu	37	12	57985144	57985144	+	Silent	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:57985144C>T	ENST00000354947.5	+	1	88	c.72C>T	c.(70-72)ttC>ttT	p.F24F	PIP4K2C_ENST00000422156.3_Silent_p.F24F|PIP4K2C_ENST00000550465.1_Silent_p.F24F|PIP4K2C_ENST00000540759.2_Silent_p.F24F			Q8TBX8	PI42C_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type II, gamma	24						cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(13)|pancreas(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	33	Melanoma(17;0.122)					GTTTCGGCTTCGCCTCCAAGA	0.652000													27	69					0	0	1	0	0
PAQR9	344838	broad.mit.edu	37	3	142681445	142681445	+	Missense_Mutation	SNP	A	A	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:142681445A>C	ENST00000340634.3	-	1	733	c.734T>G	c.(733-735)tTc>tGc	p.F245C		NM_198504.2	NP_940906.1	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	245						integral to membrane	receptor activity			endometrium(2)|large_intestine(7)|lung(12)|prostate(1)	22						GACGAAGACGAAGGTGCGCAG	0.627000													11	44					0	0	1	0	0
SOX14	8403	broad.mit.edu	37	3	137484258	137484258	+	Missense_Mutation	SNP	C	C	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:137484258C>A	ENST00000306087.1	+	1	680	c.632C>A	c.(631-633)aCc>aAc	p.T211N		NM_004189.3	NP_004180.1	O95416	SOX14_HUMAN	SRY (sex determining region Y)-box 14	211					negative regulation of transcription from RNA polymerase II promoter|nervous system development|transcription, DNA-dependent	nucleus	sequence-specific DNA binding			large_intestine(2)|lung(12)	14						TCTGCCTCCACCCTGCAGCCC	0.652000													6	22					2.7689e-08	2.85501e-08	1	1	0
NOL6	65083	broad.mit.edu	37	9	33468519	33468519	+	Nonsense_Mutation	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr9:33468519G>C	ENST00000379471.2	-	9	1280	c.1193C>G	c.(1192-1194)tCa>tGa	p.S398*	NOL6_ENST00000455041.2_Nonsense_Mutation_p.S338*|NOL6_ENST00000464829.1_Intron			Q9H6R4	NOL6_HUMAN	nucleolar protein 6 (RNA-associated)	398					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			endometrium(4)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|skin(2)	27			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		AGAGGGATCTGAGCTGAGACA	0.537000													16	34					0	0	1	0	0
LY6G6D	58530	broad.mit.edu	37	6	31675274	31675274	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr6:31675274T>C	ENST00000503322.1	+	2	95	c.92T>C	c.(91-93)gTa>gCa	p.V31A	LY6G6F_ENST00000375832.4_Missense_Mutation_p.V31A|XXbac-BPG32J3.20_ENST00000461287.1_Intron|LY6G6F_ENST00000556581.1_Missense_Mutation_p.V31A																							GGGGAGGCAGTAGAGCTGCCA	0.562000													25	41					0	0	1	0	0
AHR	196	broad.mit.edu	37	7	17379146	17379146	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr7:17379146T>C	ENST00000242057.4	+	10	2340	c.1697T>C	c.(1696-1698)tTt>tCt	p.F566S	AHR_ENST00000492120.1_3'UTR	NM_001621.4	NP_001612.1	P35869	AHR_HUMAN	aryl hydrocarbon receptor	566					apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(11)|ovary(1)|pancreas(1)|urinary_tract(3)	33	Lung NSC(10;0.0392)|all_lung(11;0.0754)					AGAAATGATTTTTCTGGTGAG	0.348000													5	91					0	0	1	0	0
MDM1	56890	broad.mit.edu	37	12	68707507	68707507	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:68707507T>C	ENST00000303145.7	-	10	1612	c.1526A>G	c.(1525-1527)aAa>aGa	p.K509R	MDM1_ENST00000540418.1_Missense_Mutation_p.K229R|MDM1_ENST00000411698.2_Missense_Mutation_p.K474R	NM_017440.4	NP_059136.2	Q8TC05	MDM1_HUMAN	Mdm1 nuclear protein homolog (mouse)	509						nucleus				breast(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(2)|skin(7)	33			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000174)		CCGGCCTCCTTTTTCTGAGGA	0.413000													19	52					0	0	1	0	0
AKAP12	9590	broad.mit.edu	37	6	151670523	151670523	+	Missense_Mutation	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr6:151670523G>C	ENST00000402676.2	+	4	1237	c.997G>C	c.(997-999)Gaa>Caa	p.E333Q	AKAP12_ENST00000359755.5_Missense_Mutation_p.E228Q|AKAP12_ENST00000354675.6_Missense_Mutation_p.E235Q|AKAP12_ENST00000253332.1_Missense_Mutation_p.E333Q	NM_005100.3	NP_005091.2	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12	333	Involved in PKC-binding (Probable).				G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	68		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		ACAAGAGCCAGAAAAAGTAGA	0.542000													10	17					0	0	1	0	0
ZNF324	25799	broad.mit.edu	37	19	58983321	58983321	+	Missense_Mutation	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:58983321C>T	ENST00000536459.2	+	4	2171	c.1462C>T	c.(1462-1464)Cgc>Tgc	p.R488C	ZNF324_ENST00000196482.3_Missense_Mutation_p.R488C|ZNF324_ENST00000535298.1_Missense_Mutation_p.R265C			O75467	Z324A_HUMAN	zinc finger protein 324	488					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(2)|prostate(2)|urinary_tract(2)	16		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		GCAGTGTGGCCGCGCCTTCCG	0.692000													8	72					0	0	1	0	0
ADIPOR1	51094	broad.mit.edu	37	1	202914181	202914181	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:202914181A>G	ENST00000340990.5	-	5	845	c.547T>C	c.(547-549)Tgc>Cgc	p.C183R	ADIPOR1_ENST00000436244.1_Missense_Mutation_p.C183R|ADIPOR1_ENST00000367254.3_Intron	NM_015999.4	NP_057083.2	Q96A54	ADR1_HUMAN	adiponectin receptor 1	183				C -> W (in Ref. 4; BAG50922).	fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane|plasma membrane	hormone binding|protein kinase binding|receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	16			BRCA - Breast invasive adenocarcinoma(75;0.141)			AAGCTGAGGCAGAGCACTGCA	0.443000													34	52					0	0	1	0	0
ERN2	10595	broad.mit.edu	37	16	23703337	23703337	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr16:23703337C>G	ENST00000256797.4	-	19	2635	c.2467G>C	c.(2467-2469)Gtg>Ctg	p.V823L	ERN2_ENST00000457008.2_Missense_Mutation_p.V723L	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	775	KEN.				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		TGGGCCAGCACCTGGGGGGCA	0.602000													74	143					0	0	1	0	0
ENOX1	55068	broad.mit.edu	37	13	43798238	43798238	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr13:43798238C>G	ENST00000261488.6	-	16	2328	c.1751G>C	c.(1750-1752)gGa>gCa	p.G584A	ENOX1_ENST00000412891.1_Missense_Mutation_p.G584A	NM_001242863.1|NM_017993.3	NP_001229792.1|NP_060463.2	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	584					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			breast(1)|endometrium(3)|large_intestine(7)|lung(18)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(1)	34		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		TATGTTGGCTCCAAAAGGATG	0.363000													10	7					0	0	1	0	0
OPN1MW	2652	broad.mit.edu	37	X	153459033	153459033	+	Silent	SNP	C	C	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chrX:153459033C>A	ENST00000369935.5	+	5	939	c.879C>A	c.(877-879)gcC>gcA	p.A293A		NM_000513.2	NP_000504.1	P04001	OPSG_HUMAN	opsin 1 (cone pigments), medium-wave-sensitive	293					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			endometrium(1)|lung(1)	2	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TTGCTGCTGCCAACCCTGGCT	0.547000													35	58					1.21353e-23	1.30432e-23	1	1	0
CUL9	23113	broad.mit.edu	37	6	43153711	43153711	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr6:43153711T>C	ENST00000252050.4	+	4	853	c.769T>C	c.(769-771)Ttc>Ctc	p.F257L	CUL9_ENST00000354495.3_Missense_Mutation_p.F257L|CUL9_ENST00000372647.2_Missense_Mutation_p.F257L	NM_015089.2	NP_055904.1	Q8IWT3	CUL9_HUMAN	cullin 9	257					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|liver(1)|lung(30)|ovary(5)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(4)	92						AAAGCTGCTTTTCTCCTTGGT	0.532000													14	52					0	0	1	0	0
HMGXB4	10042	broad.mit.edu	37	22	35660790	35660790	+	Missense_Mutation	SNP	T	T	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr22:35660790T>A	ENST00000216106.5	+	5	537	c.409T>A	c.(409-411)Tct>Act	p.S137T	HMGXB4_ENST00000444518.2_Missense_Mutation_p.S28T	NM_001003681.2	NP_001003681.1	Q9UGU5	HMGX4_HUMAN	HMG box domain containing 4	137					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|endometrium(1)|large_intestine(6)|liver(1)|lung(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						ATCCTCTGGCTCTTCAAGCCA	0.512000													31	44					0	0	1	0	0
C6orf165	154313	broad.mit.edu	37	6	88126385	88126385	+	Splice_Site	SNP	A	A	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr6:88126385A>C	ENST00000507897.1	+	6	555		c.e6-1		C6ORF165_ENST00000369562.4_Splice_Site			Q8IYR0	CF165_HUMAN	chromosome 6 open reading frame 165											NS(1)|central_nervous_system(1)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		GGTTTATTTTAGCTGCTCTAC	0.358000													29	8					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54806578	54806578	+	Missense_Mutation	SNP	T	T	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr6:54806578T>A	ENST00000306858.7	+	5	2925	c.2809T>A	c.(2809-2811)Ttt>Att	p.F937I		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	937										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					TTACAGTCGTTTTGAGCCGTT	0.443000													4	114					0	0	1	0	0
APITD1	378708	broad.mit.edu	37	1	10511484	10511484	+	Silent	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:10511484C>G	ENST00000602787.1	+	5	743	c.327C>G	c.(325-327)ctC>ctG	p.L109L	CORT_ENST00000320498.4_Silent_p.L100L|APITD1-CORT_ENST00000465026.1_3'UTR|CORT_ENST00000377049.3_Silent_p.L50L|APITD1-CORT_ENST00000470413.2_3'UTR|APITD1-CORT_ENST00000400900.2_Silent_p.L109L|APITD1_ENST00000602296.1_3'UTR	NM_198544.3	NP_940946.1			apoptosis-inducing, TAF9-like domain 1											kidney(1)|lung(1)|ovary(1)|stomach(1)	4	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.31e-07)|COAD - Colon adenocarcinoma(227;7.32e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000297)|Kidney(185;0.000747)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		TGACTTTCCTCGCTTGGTGGT	0.582000													13	13					0	0	1	0	0
ZSCAN29	146050	broad.mit.edu	37	15	43662015	43662015	+	Missense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr15:43662015G>A	ENST00000396976.2	-	1	231	c.97C>T	c.(97-99)Cgg>Tgg	p.R33W	ZSCAN29_ENST00000568898.1_Missense_Mutation_p.R32W|ZSCAN29_ENST00000562072.1_Missense_Mutation_p.R32W|TUBGCP4_ENST00000570081.1_Intron|ZSCAN29_ENST00000396972.1_Missense_Mutation_p.R33W	NM_152455.3	NP_689668.3	Q8IWY8	ZSC29_HUMAN	zinc finger and SCAN domain containing 29	33	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(9)|lung(7)|skin(2)	24		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.97e-07)		AAAGCCTCCCGCGGCCCAGCC	0.532000													25	48					0	0	1	0	0
ABCA2	20	broad.mit.edu	37	9	139909368	139909368	+	Missense_Mutation	SNP	G	G	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr9:139909368G>T	ENST00000265662.5	-	25	4026	c.3879C>A	c.(3877-3879)ttC>ttA	p.F1293L	ABCA2_ENST00000341511.6_Missense_Mutation_p.F1293L|ABCA2_ENST00000371605.3_Missense_Mutation_p.F1292L			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	1292					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CTCACACCTGGAAGAGGCGCT	0.697000													8	6					0.00307968	0.00310127	1	1	0
KRT40	125115	broad.mit.edu	37	17	39137378	39137378	+	Missense_Mutation	SNP	A	A	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr17:39137378A>C	ENST00000377755.4	-	4	747	c.713T>G	c.(712-714)cTt>cGt	p.L238R	KRT40_ENST00000398486.2_Missense_Mutation_p.L238R			Q6A162	K1C40_HUMAN	keratin 40	238	Linker 12.|Rod.					intermediate filament	structural molecule activity			endometrium(1)|large_intestine(2)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	9		Breast(137;0.00043)				GCGGTCGCCAAGCTGTTCACG	0.517000													37	104					0	0	1	0	0
TAOK2	9344	broad.mit.edu	37	16	29994070	29994070	+	Missense_Mutation	SNP	C	C	T	rs141012429		TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr16:29994070C>T	ENST00000308893.4	+	11	1890	c.847C>T	c.(847-849)Cgg>Tgg	p.R283W	TAOK2_ENST00000279394.3_Missense_Mutation_p.R283W|TAOK2_ENST00000543033.1_Missense_Mutation_p.R283W|TAOK2_ENST00000416441.2_Missense_Mutation_p.R110W	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	283					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						CTTTGTGCTCCGGGAGCGGCC	0.622000													12	28					0	0	1	0	0
AVL9	23080	broad.mit.edu	37	7	32623485	32623485	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr7:32623485A>G	ENST00000318709.4	+	16	2134	c.1913A>G	c.(1912-1914)cAa>cGa	p.Q638R	AVL9_ENST00000404479.1_Intron|AVL9_ENST00000409301.1_Missense_Mutation_p.Q620R	NM_015060.1	NP_055875.1	Q8NBF6	AVL9_HUMAN	AVL9 homolog (S. cerevisiase)	638						integral to membrane				endometrium(3)|kidney(1)|large_intestine(3)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18						TCCACCTCCCAAAGTCTCACT	0.512000													21	25					0	0	1	0	0
CCDC97	90324	broad.mit.edu	37	19	41825748	41825748	+	Missense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:41825748G>A	ENST00000269967.3	+	3	894	c.772G>A	c.(772-774)Gac>Aac	p.D258N		NM_052848.1	NP_443080.1	Q96F63	CCD97_HUMAN	coiled-coil domain containing 97	258										biliary_tract(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)	17						ggaggacagtgacgaggaagg	0.627000													5	17					0	0	1	0	0
TANC1	85461	broad.mit.edu	37	2	159954194	159954194	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:159954194A>G	ENST00000263635.6	+	4	344	c.107A>G	c.(106-108)cAc>cGc	p.H36R	TANC1_ENST00000454300.1_Missense_Mutation_p.H36R	NM_001145909.1|NM_033394.2	NP_001139381.1|NP_203752.2	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	36						cell junction|postsynaptic density|postsynaptic membrane	binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(25)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	77						CACCTTGACCACAGTGCTGAC	0.488000													35	43					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36214052	36214052	+	Missense_Mutation	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr4:36214052C>T	ENST00000303965.4	-	5	1588	c.1099G>A	c.(1099-1101)Gct>Act	p.A367T		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	367					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						GTTGCAGTAGCTGCTTCCCCT	0.323000													18	17					0	0	1	0	0
EDA2R	60401	broad.mit.edu	37	X	65824289	65824289	+	Missense_Mutation	SNP	T	T	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chrX:65824289T>A	ENST00000374719.3	-	4	382	c.326A>T	c.(325-327)aAg>aTg	p.K109M	EDA2R_ENST00000450752.1_Missense_Mutation_p.K109M|EDA2R_ENST00000253392.5_Missense_Mutation_p.K109M|EDA2R_ENST00000396050.1_Missense_Mutation_p.K109M|EDA2R_ENST00000451436.2_Intron|EDA2R_ENST00000456230.2_Missense_Mutation_p.K109M	NM_021783.3	NP_068555	Q9HAV5	TNR27_HUMAN	ectodysplasin A2 receptor	109					cell differentiation|embryo development|epidermis development|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity	integral to plasma membrane	tumor necrosis factor receptor activity			breast(1)|endometrium(2)|large_intestine(4)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	13						GGGGGTCTGCTTCGTGCACGG	0.512000													21	41					0	0	1	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20870110	20870110	+	Silent	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:20870110C>T	ENST00000381552.1	+	7	1089	c.721C>T	c.(721-723)Ctg>Ttg	p.L241L	SLCO1C1_ENST00000266509.2_Silent_p.L241L|SLCO1C1_ENST00000540354.1_Silent_p.L192L|SLCO1C1_ENST00000545604.1_Silent_p.L241L|SLCO1C1_ENST00000545102.1_Silent_p.L123L			Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1	241					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					CTTTGGTTTCCTGTTAGGCTC	0.333000													34	32					0	0	1	0	0
TCEB3CL	728929	broad.mit.edu	37	18	44549232	44549232	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr18:44549232T>C	ENST00000451265.1	-	1	1302	c.1067A>G	c.(1066-1068)gAa>gGa	p.E356G	KATNAL2_ENST00000592005.1_Intron|KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron	NM_001100817.1	NP_001094287.1			transcription elongation factor B polypeptide 3C-like											central_nervous_system(1)|lung(1)|prostate(1)	3						GGGGACCCCTTCCACGTCGCC	0.652000													14	436					0	0	1	0	0
ZNF492	57615	broad.mit.edu	37	19	22847050	22847050	+	Silent	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:22847050A>G	ENST00000456783.2	+	4	823	c.579A>G	c.(577-579)ggA>ggG	p.G193G		NM_020855.2	NP_065906.1	Q9P255	ZN492_HUMAN	zinc finger protein 492	193					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				TTCATACTGGAAAGAAACCCT	0.368000													10	16					0	0	1	0	0
TFDP1	7027	broad.mit.edu	37	13	114287563	114287563	+	Missense_Mutation	SNP	T	T	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr13:114287563T>G	ENST00000375370.5	+	6	649	c.437T>G	c.(436-438)tTc>tGc	p.F146C	TFDP1_ENST00000465174.1_3'UTR|TFDP1_ENST00000538138.1_Missense_Mutation_p.F51C|TFDP1_ENST00000544902.1_Missense_Mutation_p.F51C	NM_007111.4	NP_009042.1	Q14186	TFDP1_HUMAN	transcription factor Dp-1	146					cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(10)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.132)|all_epithelial(44;0.0731)|all_lung(25;0.149)|Breast(118;0.153)	all cancers(43;0.0576)			GTTGCGGAGTTCAGTGCTGCC	0.597000										TSP Lung(29;0.18)			19	25					0	0	1	0	0
SLC16A1	6566	broad.mit.edu	37	1	113456623	113456623	+	Nonsense_Mutation	SNP	C	C	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:113456623C>A	ENST00000538576.1	-	5	2224	c.1393G>T	c.(1393-1395)Gag>Tag	p.E465*	SLC16A1_ENST00000369626.3_Nonsense_Mutation_p.E465*	NM_001166496.1	NP_001159968.1	P53985	MOT1_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 1	465					blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	integral to membrane|membrane fraction|plasma membrane	mevalonate transmembrane transporter activity|protein binding|secondary active monocarboxylate transmembrane transporter activity|symporter activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|urinary_tract(1)	20	Lung SC(450;0.246)	all_cancers(81;7.6e-08)|all_epithelial(167;3.82e-07)|all_lung(203;3.07e-05)|Lung NSC(69;5.51e-05)|Prostate(1639;0.00232)		Epithelial(280;7.31e-13)|all cancers(265;5.1e-10)|Kidney(133;5.29e-07)|KIRC - Kidney renal clear cell carcinoma(1967;8.63e-06)|OV - Ovarian serous cystadenocarcinoma(397;1.48e-05)|BRCA - Breast invasive adenocarcinoma(282;0.003)|LUSC - Lung squamous cell carcinoma(189;0.008)|Lung(183;0.00948)|Colorectal(144;0.0325)|COAD - Colon adenocarcinoma(174;0.0643)	Pyruvic acid(DB00119)	ATACTGGTCTCTTCCTCTTTA	0.438000													32	124					9.78306e-22	1.04888e-21	1	1	0
CENPJ	55835	broad.mit.edu	37	13	25480492	25480492	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr13:25480492C>G	ENST00000381884.4	-	7	1869	c.1684G>C	c.(1684-1686)Gag>Cag	p.E562Q	CENPJ_ENST00000545981.1_Missense_Mutation_p.E562Q	NM_018451.4	NP_060921.3	Q9HC77	CENPJ_HUMAN	centromere protein J	562					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			endometrium(5)|kidney(4)|large_intestine(14)|lung(13)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		TCCCAAGTCTCTAACTTTTTC	0.408000													13	37					0	0	1	0	0
HIST1H2BA	255626	broad.mit.edu	37	6	25727230	25727230	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr6:25727230A>G	ENST00000274764.2	+	1	94	c.94A>G	c.(94-96)Aag>Gag	p.K32E		NM_170610.2	NP_733759.1	Q96A08	H2B1A_HUMAN	histone cluster 1, H2ba	32					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|kidney(1)	2						CAAAAAGCGCAAGAGGACCCG	0.448000													40	49					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554413	140554413	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr5:140554413T>C	ENST00000231137.3	+	1	2171	c.1997T>C	c.(1996-1998)tTc>tCc	p.F666S		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		666	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTGGACGGCTTCTCCCAGCCC	0.697000													18	83					0	0	1	0	0
ANKRD17	26057	broad.mit.edu	37	4	73957549	73957549	+	Silent	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr4:73957549C>T	ENST00000358602.4	-	29	5912	c.5796G>A	c.(5794-5796)ttG>ttA	p.L1932L	ANKRD17_ENST00000509867.2_Silent_p.L1819L|ANKRD17_ENST00000330838.6_Silent_p.L1681L	NM_032217.3	NP_115593.3	O75179	ANR17_HUMAN	ankyrin repeat domain 17	1932					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			NS(3)|breast(2)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(39)|ovary(6)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)	96	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TGGCAGGGCTCAAAGGCCTGA	0.522000													21	28					0	0	1	0	0
NRF1	4899	broad.mit.edu	37	7	129348983	129348983	+	Silent	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr7:129348983G>C	ENST00000393232.1	+	6	792	c.675G>C	c.(673-675)ggG>ggC	p.G225G	NRF1_ENST00000353868.4_Silent_p.G225G|NRF1_ENST00000311967.2_Silent_p.G225G|NRF1_ENST00000393231.3_Silent_p.G225G|NRF1_ENST00000539636.1_Silent_p.G64G|NRF1_ENST00000223190.4_Silent_p.G225G|NRF1_ENST00000393230.2_Silent_p.G225G	NM_005011.3	NP_005002.3	Q16656	NRF1_HUMAN	nuclear respiratory factor 1	225					generation of precursor metabolites and energy|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding			breast(2)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)	24						CAGGCTGGGGGAAAGAAAGCT	0.532000													75	155					0	0	1	0	0
SNTG1	54212	broad.mit.edu	37	8	51415380	51415380	+	Missense_Mutation	SNP	G	G	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr8:51415380G>T	ENST00000522124.1	+	9	1067	c.406G>T	c.(406-408)Gtg>Ttg	p.V136L	SNTG1_ENST00000276467.5_Missense_Mutation_p.V136L|SNTG1_ENST00000518864.1_Missense_Mutation_p.V136L|SNTG1_ENST00000517473.1_Missense_Mutation_p.V136L	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	136	PDZ.				cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				GACTCTAACAGTGTCATTTTT	0.328000													13	48					2.31682e-05	2.36064e-05	1	1	0
KCNV1	27012	broad.mit.edu	37	8	110984995	110984995	+	Silent	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr8:110984995C>G	ENST00000524391.1	-	3	1515	c.483G>C	c.(481-483)ctG>ctC	p.L161L	KCNV1_ENST00000297404.1_Silent_p.L161L			Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	161						voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(20)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			AAGTTTCACTCAGCTCTTTCC	0.388000													12	80					0	0	1	0	0
UROD	7389	broad.mit.edu	37	1	45478813	45478813	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:45478813A>G	ENST00000246337.4	+	3	258	c.139A>G	c.(139-141)Agg>Ggg	p.R47G	UROD_ENST00000494399.1_3'UTR	NM_000374.4	NP_000365.3	P06132	DCUP_HUMAN	uroporphyrinogen decarboxylase	47						cytosol|microtubule cytoskeleton|nucleus	uroporphyrinogen decarboxylase activity			endometrium(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	4	Acute lymphoblastic leukemia(166;0.155)					TGCAGAGTTTAGGGAAACCCG	0.567000									Porphyria Cutanea Tarda, Type II				28	83					0	0	1	0	0
PRX	57716	broad.mit.edu	37	19	40902557	40902557	+	Missense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:40902557G>A	ENST00000324001.7	-	7	1972	c.1702C>T	c.(1702-1704)Cgg>Tgg	p.R568W	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	568	55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TCTGGAAGCCGCACCTCTGGC	0.557000													4	264					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123145808	123145808	+	Silent	SNP	T	T	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr4:123145808T>G	ENST00000264501.4	+	23	3142	c.2769T>G	c.(2767-2769)ctT>ctG	p.L923L	KIAA1109_ENST00000388738.3_Silent_p.L923L|KIAA1109_ENST00000455637.1_Silent_p.L923L|KIAA1109_ENST00000495260.1_3'UTR			Q2LD37	K1109_HUMAN	KIAA1109	923					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						CTGGAAGTCTTACAGCTAAGG	0.438000													11	18					0	0	1	0	0
DEPTOR	64798	broad.mit.edu	37	8	121013945	121013945	+	Missense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr8:121013945G>A	ENST00000286234.5	+	5	916	c.786G>A	c.(784-786)atG>atA	p.M262I	DEPTOR_ENST00000518057.1_3'UTR|DEPTOR_ENST00000523492.1_Missense_Mutation_p.M161I	NM_022783.2	NP_073620.2	Q8TB45	DPTOR_HUMAN	DEP domain containing MTOR-interacting protein	262	Ser-rich.				intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	18						CCAGCTTTATGTCAGGTATGC	0.463000													12	26					0	0	1	0	0
UBE4B	10277	broad.mit.edu	37	1	10179641	10179641	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:10179641T>C	ENST00000377157.3	+	8	1735	c.674T>C	c.(673-675)tTa>tCa	p.L225S	UBE4B_ENST00000475795.1_3'UTR|UBE4B_ENST00000253251.8_Missense_Mutation_p.L341S|UBE4B_ENST00000343090.6_Missense_Mutation_p.L470S	NM_006048.4	NP_006039.2	O95155	UBE4B_HUMAN	ubiquitination factor E4B	470					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			NS(3)|breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(14)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	48		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		CATACTGCTTTAGTACTACAA	0.537000													29	85					0	0	1	0	0
C16orf71	146562	broad.mit.edu	37	16	4790260	4790260	+	Missense_Mutation	SNP	A	A	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr16:4790260A>T	ENST00000299320.5	+	4	861	c.383A>T	c.(382-384)gAa>gTa	p.E128V	C16orf71_ENST00000590191.1_Missense_Mutation_p.E142V|RP11-127I20.7_ENST00000588099.1_RNA	NM_139170.2	NP_631909.2	Q8IYS4	CP071_HUMAN	chromosome 16 open reading frame 71	128										breast(1)|central_nervous_system(1)|large_intestine(4)|lung(4)|ovary(1)	11						AGGCCTTTTGAAAGCTCTGGT	0.572000													28	45					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56374502	56374502	+	Missense_Mutation	SNP	T	T	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr6:56374502T>G	ENST00000370754.5	-	74	18856	c.18857A>C	c.(18856-18858)aAa>aCa	p.K6286T	DST_ENST00000312431.6_3'UTR|DST_ENST00000244364.6_Missense_Mutation_p.K3694T|DST_ENST00000370769.4_Missense_Mutation_p.K6108T|DST_ENST00000361203.3_Missense_Mutation_p.K5997T|DST_ENST00000370788.2_Missense_Mutation_p.K3911T|DST_ENST00000446842.2_Missense_Mutation_p.K5782T|DST_ENST00000421834.2_Missense_Mutation_p.K4020T|DST_ENST00000340834.4_5'UTR			Q03001	DYST_HUMAN	dystonin	6106					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TCCCCTCTGTTTAAGAGTTTC	0.388000													25	45					0	0	1	0	0
BUB1	699	broad.mit.edu	37	2	111398707	111398707	+	Missense_Mutation	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:111398707C>T	ENST00000535254.1	-	22	2866	c.2799G>A	c.(2797-2799)atG>atA	p.M933I	BUB1_ENST00000302759.6_Missense_Mutation_p.M953I|BUB1_ENST00000409311.1_Missense_Mutation_p.M896I	NM_001278616.1	NP_001265545.1	O43683	BUB1_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase	953	Protein kinase.				apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			breast(3)|endometrium(8)|kidney(4)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|stomach(1)	45		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		GAAAAAGTTTCATATCTATAC	0.383000													17	43					0	0	1	0	0
ATG2A	23130	broad.mit.edu	37	11	64681381	64681381	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr11:64681381T>C	ENST00000421419.2	-	4	616	c.502A>G	c.(502-504)Aaa>Gaa	p.K168E	ATG2A_ENST00000377264.3_Missense_Mutation_p.K168E			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	168							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						AAGGTCACTTTGATCCTCCGA	0.622000													5	12					0	0	1	0	0
PIGR	5284	broad.mit.edu	37	1	207111051	207111051	+	Missense_Mutation	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:207111051C>T	ENST00000356495.4	-	4	617	c.434G>A	c.(433-435)gGc>gAc	p.G145D		NM_002644.3	NP_002635.2	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor	145	Ig-like V-type 2.					extracellular region|integral to plasma membrane	protein binding			central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						CACCGTTCTGCCCAGGTCCAC	0.512000													8	13					0	0	1	0	0
ESD	2098	broad.mit.edu	37	13	47355699	47355699	+	Missense_Mutation	SNP	T	T	C	rs146164024		TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr13:47355699T>C	ENST00000378720.3	-	7	615	c.433A>G	c.(433-435)Att>Gtt	p.I145V	ESD_ENST00000495654.1_5'UTR|ESD_ENST00000378697.1_Missense_Mutation_p.I116V	NM_001984.1	NP_001975.1	P10768	ESTD_HUMAN	esterase D	145						cytoplasmic membrane-bounded vesicle	carboxylesterase activity|S-formylglutathione hydrolase activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)	9		all_lung(13;3.54e-08)|Lung NSC(96;9.1e-06)|Breast(56;0.000148)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)		GBM - Glioblastoma multiforme(144;2.66e-05)	Glutathione(DB00143)	TGGCCAAAAATAGACATCCTT	0.348000													41	29					0	0	1	0	0
TBCC	6903	broad.mit.edu	37	6	42713733	42713733	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr6:42713733C>G	ENST00000244625.2	-	2	642	c.79G>C	c.(79-81)Gag>Cag	p.E27Q	TBCC_ENST00000372876.1_Missense_Mutation_p.E27Q			Q15814	TBCC_HUMAN	tubulin folding cofactor C	27					'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway	cytoplasm|microtubule|photoreceptor connecting cilium	chaperone binding|GTPase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(3)	14	Colorectal(47;0.196)		all cancers(41;0.00122)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.125)			TGAAGCCGCTCAGGCACCAGG	0.562000													40	43					0	0	1	0	0
CRB2	286204	broad.mit.edu	37	9	126136070	126136070	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr9:126136070A>G	ENST00000373631.3	+	10	3261	c.3260A>G	c.(3259-3261)gAa>gGa	p.E1087G	CRB2_ENST00000373629.2_Missense_Mutation_p.E755G|CRB2_ENST00000359999.3_Missense_Mutation_p.E1087G	NM_173689.5	NP_775960.4	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 (Drosophila)	1087	EGF-like 12.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(1)|endometrium(2)|lung(11)|ovary(1)|prostate(2)|skin(3)	23						CCGGGGTGGGAAGGCCCGCGC	0.756000													4	8					0	0	1	0	0
PDIA4	9601	broad.mit.edu	37	7	148701040	148701040	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr7:148701040T>C	ENST00000286091.4	-	10	2016	c.1784A>G	c.(1783-1785)tAt>tGt	p.Y595C		NM_004911.4	NP_004902.1	P13667	PDIA4_HUMAN	protein disulfide isomerase family A, member 4	595	Thioredoxin 3.				cell redox homeostasis|glycerol ether metabolic process|protein secretion	endoplasmic reticulum lumen|melanosome	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			large_intestine(6)|lung(15)|ovary(2)|prostate(1)	24	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00385)			CTCCACCTTATAGCGGTCGCT	0.567000													6	24					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115380420	115380420	+	Silent	SNP	G	G	C	rs149084999		TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr10:115380420G>C	ENST00000369358.4	-	25	3085	c.2841C>G	c.(2839-2841)gtC>gtG	p.V947V	NRAP_ENST00000369360.3_Silent_p.V912V|NRAP_ENST00000359988.3_Silent_p.V939V|NRAP_ENST00000360478.3_Silent_p.V904V			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	939						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		ACCCGGTGGCGACCCAGCCCA	0.498000													26	51					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56204574	56204574	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr18:56204574C>G	ENST00000361673.3	-	5	3058	c.2845G>C	c.(2845-2847)Gag>Cag	p.E949Q	RP11-1151B14.4_ENST00000591360.1_RNA	NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	949							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						GGATTGTTCTCAGAAGAAAGG	0.517000													14	27					0	0	1	0	0
TGM3	7053	broad.mit.edu	37	20	2290830	2290830	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr20:2290830A>G	ENST00000381458.5	+	3	251	c.188A>G	c.(187-189)tAc>tGc	p.Y63C		NM_003245.3	NP_003236.3	Q08188	TGM3_HUMAN	transglutaminase 3	63					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(11)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	39					L-Glutamine(DB00130)	ACAGGGCCTTACCCCTCAGAG	0.547000													33	90					0	0	1	0	0
GYG2	8908	broad.mit.edu	37	X	2793878	2793878	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chrX:2793878C>G	ENST00000381163.3	+	10	1441	c.1159C>G	c.(1159-1161)Cct>Gct	p.P387A	GYG2_ENST00000338623.5_Missense_Mutation_p.P387A|GYG2_ENST00000542787.1_Intron|GYG2_ENST00000381161.1_Intron|GYG2_ENST00000398806.3_Missense_Mutation_p.P356A	NM_001079855.1|NM_001184702.1|NM_003918.2	NP_001073324.1|NP_001171631.1|NP_003909.2	O15488	GLYG2_HUMAN	glycogenin 2	387					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|soluble fraction	glycogenin glucosyltransferase activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)	13		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AACTGAGACTCCTGCCGTGAT	0.428000													6	14					0	0	1	0	0
IRX1	79192	broad.mit.edu	37	5	3600248	3600248	+	Missense_Mutation	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr5:3600248G>C	ENST00000302006.3	+	2	1238	c.1186G>C	c.(1186-1188)Gct>Cct	p.A396P	CTD-2012M11.3_ENST00000559410.1_RNA	NM_024337.3	NP_077313.3	P78414	IRX1_HUMAN	iroquois homeobox 1	396						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(18)|ovary(2)|pancreas(1)|prostate(5)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						GGGCGTTGGCGCTCCCCACGC	0.657000													8	12					0	0	1	0	0
FKBP9	11328	broad.mit.edu	37	7	33028194	33028194	+	Silent	SNP	T	T	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr7:33028194T>A	ENST00000242209.4	+	6	1138	c.969T>A	c.(967-969)ctT>ctA	p.L323L	FKBP9_ENST00000490776.2_Silent_p.L91L|FKBP9_ENST00000538336.1_Silent_p.L376L|FKBP9_ENST00000489038.1_3'UTR|AVL9_ENST00000404479.1_Intron|FKBP9_ENST00000538443.1_Silent_p.L185L	NM_001284343.1|NM_007270.3	NP_001271272.1|NP_009201.2	O95302	FKBP9_HUMAN	FK506 binding protein 9, 63 kDa	323	PPIase FKBP-type 3.				protein folding	endoplasmic reticulum|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(13)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	39			GBM - Glioblastoma multiforme(11;0.0156)			AAGGTCTACTTGGTGTTTGCA	0.512000													12	59					0	0	1	0	0
CSTF3	1479	broad.mit.edu	37	11	33117864	33117864	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr11:33117864A>G	ENST00000323959.4	-	15	1502	c.1363T>C	c.(1363-1365)Tct>Cct	p.S455P	TCP11L1_ENST00000324357.9_Intron	NM_001326.2	NP_001317.1	Q12996	CSTF3_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa	455					mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|prostate(1)|skin(1)|stomach(1)	19						TTGAGGTGAGAAAGATAGTCA	0.333000													20	26					0	0	1	0	0
SMARCA4	6597	broad.mit.edu	37	19	11152036	11152036	+	Missense_Mutation	SNP	A	A	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:11152036A>T	ENST00000358026.2	+	31	4604	c.4320A>T	c.(4318-4320)aaA>aaT	p.K1440N	SMARCA4_ENST00000413806.3_Missense_Mutation_p.K1378N|SMARCA4_ENST00000538456.3_3'UTR|SMARCA4_ENST00000344626.4_Missense_Mutation_p.K1408N|SMARCA4_ENST00000590574.1_Missense_Mutation_p.K1375N|SMARCA4_ENST00000450717.3_Missense_Mutation_p.K1378N|SMARCA4_ENST00000589677.1_Missense_Mutation_p.K1378N|SMARCA4_ENST00000541122.2_Missense_Mutation_p.K1378N|SMARCA4_ENST00000444061.3_Missense_Mutation_p.K1375N|SMARCA4_ENST00000429416.3_Missense_Mutation_p.K1408N	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	1408					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GGCAGAAGAAATCATCACGGA	0.602000			"""F, N, Mis"""		NSCLC								4	48					0	0	1	0	0
PTPRU	10076	broad.mit.edu	37	1	29639158	29639158	+	Missense_Mutation	SNP	T	T	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:29639158T>A	ENST00000323874.8	+	23	3295	c.3185T>A	c.(3184-3186)tTc>tAc	p.F1062Y	PTPRU_ENST00000373779.3_Missense_Mutation_p.F1056Y|PTPRU_ENST00000345512.3_Missense_Mutation_p.F1066Y|PTPRU_ENST00000428026.2_Missense_Mutation_p.F1053Y|PTPRU_ENST00000356870.3_Missense_Mutation_p.F1062Y|PTPRU_ENST00000460170.2_Missense_Mutation_p.F1062Y|PTPRU_ENST00000415600.2_3'UTR			Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	1066	Tyrosine-protein phosphatase 1.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(26)|ovary(1)|prostate(3)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	79		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		CTGCTGGCTTTCATCCGGCGC	0.662000													8	10					0	0	1	0	0
PPIF	10105	broad.mit.edu	37	10	81113542	81113542	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr10:81113542A>G	ENST00000225174.3	+	6	639	c.568A>G	c.(568-570)Aag>Gag	p.K190E	PPIF_ENST00000394579.3_3'UTR	NM_005729.3	NP_005720.1	P30405	PPIF_HUMAN	peptidylprolyl isomerase F	190	PPIase cyclophilin-type.				protein folding	membrane fraction|mitochondrial matrix	peptidyl-prolyl cis-trans isomerase activity			endometrium(2)|lung(2)|skin(2)	6	all_cancers(46;0.0893)|Breast(12;8.52e-05)|all_epithelial(25;0.00449)|Prostate(51;0.00985)		Epithelial(14;0.00242)|all cancers(16;0.0069)|Colorectal(32;0.229)		Dimethyl sulfoxide(DB01093)|L-Proline(DB00172)	TTTCGGCTCTAAGAGTGGGAG	0.527000													19	32					0	0	1	0	0
C6orf195	154386	broad.mit.edu	37	6	2623977	2623977	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr6:2623977T>C	ENST00000296847.3	-	3	603	c.80A>G	c.(79-81)gAa>gGa	p.E27G		NM_152554.2	NP_689767.2	Q96MT4	CF195_HUMAN	chromosome 6 open reading frame 195	27										cervix(1)|endometrium(1)|lung(2)|skin(1)	5	Ovarian(93;0.0412)	all_hematologic(90;0.0895)				AAATGCCCTTTCTCCCTCGGG	0.572000													25	23					0	0	1	0	0
GPNMB	10457	broad.mit.edu	37	7	23313188	23313188	+	Missense_Mutation	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr7:23313188G>C	ENST00000258733.4	+	10	1773	c.1478G>C	c.(1477-1479)gGc>gCc	p.G493A	GPNMB_ENST00000539136.1_Missense_Mutation_p.G394A|GPNMB_ENST00000478451.1_3'UTR|GPNMB_ENST00000453162.2_Missense_Mutation_p.G447A|GPNMB_ENST00000381990.2_Missense_Mutation_p.G505A			Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb	505					negative regulation of cell proliferation	melanosome				breast(5)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(3)|stomach(2)	41			GBM - Glioblastoma multiforme(13;0.154)			ATCTCCGTTGGCTGCTTGGCC	0.433000													60	52					0	0	1	0	0
NLK	51701	broad.mit.edu	37	17	26459652	26459652	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr17:26459652T>C	ENST00000407008.3	+	3	1313	c.595T>C	c.(595-597)Tct>Cct	p.S199P		NM_016231.4	NP_057315.3	Q9UBE8	NLK_HUMAN	nemo-like kinase	199	Protein kinase.				intracellular protein kinase cascade|negative regulation of Wnt receptor signaling pathway|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|serine phosphorylation of STAT3 protein|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|MAP kinase activity|SH2 domain binding|transcription factor binding|ubiquitin protein ligase binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(1)	14	all_lung(13;0.000343)|Lung NSC(42;0.00184)			UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		TCAGGTACTCTCTGCCCTTGA	0.318000													5	7					0	0	1	0	0
SLC27A5	10998	broad.mit.edu	37	19	59010948	59010948	+	Silent	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:59010948C>G	ENST00000263093.2	-	7	1687	c.1578G>C	c.(1576-1578)tcG>tcC	p.S526S	SLC27A5_ENST00000601355.1_Silent_p.S442S	NM_012254.2	NP_036386.1	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid transporter), member 5	526					bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		AAACGTCGCCCGATTGCCGCA	0.657000													21	167					0	0	1	0	0
SLC17A8	246213	broad.mit.edu	37	12	100774578	100774578	+	Silent	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:100774578C>T	ENST00000323346.5	+	2	514	c.201C>T	c.(199-201)tgC>tgT	p.C67C	SLC17A8_ENST00000392989.3_Silent_p.C67C	NM_001145288.1|NM_139319.2	NP_001138760.1|NP_647480.1	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 8	67					neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	44						TCTGCGACTGCCACTGCTGCG	0.532000													26	82					0	0	1	0	0
CENPL	91687	broad.mit.edu	37	1	173772368	173772368	+	Silent	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:173772368A>G	ENST00000356198.2	-	6	1119	c.834T>C	c.(832-834)caT>caC	p.H278H	CENPL_ENST00000367710.3_Silent_p.H232H|CENPL_ENST00000345664.6_Silent_p.H232H	NM_001127181.2	NP_001120653.1	Q8N0S6	CENPL_HUMAN	centromere protein L	232					mitotic prometaphase	chromosome, centromeric region|cytosol|nucleus				breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(3)	11						TAGCCACATAATGGTCCATTT	0.423000													20	42					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48389453	48389453	+	Missense_Mutation	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr10:48389453G>C	ENST00000224600.4	-	1	1538	c.1425C>G	c.(1423-1425)atC>atG	p.I475M		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	475	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	GCAGGTCCATGATGAGGTGCT	0.642000													10	28					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124270481	124270481	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:124270481C>G	ENST00000409039.3	+	9	1261	c.1236C>G	c.(1234-1236)ttC>ttG	p.F412L		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	412	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GGACTTTGTTCAAGTAAGAAG	0.408000													10	28					0	0	1	0	0
TAC3	6866	broad.mit.edu	37	12	57406214	57406214	+	Missense_Mutation	SNP	T	T	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:57406214T>G	ENST00000458521.2	-	6	474	c.315A>C	c.(313-315)caA>caC	p.Q105H	TAC3_ENST00000441881.1_Missense_Mutation_p.Q87H|TAC3_ENST00000415231.1_Missense_Mutation_p.Q105H	NM_013251.3	NP_037383.1	Q9UHF0	TKNK_HUMAN	tachykinin 3	105					female pregnancy|neuropeptide signaling pathway|tachykinin receptor signaling pathway	extracellular space|soluble fraction	receptor binding			cervix(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	7						GGACGTTCTCTTGATTCACAT	0.512000													3	20					0	0	1	0	0
MFSD2B	388931	broad.mit.edu	37	2	24244560	24244560	+	Missense_Mutation	SNP	T	T	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:24244560T>A	ENST00000338315.4	+	7	724	c.724T>A	c.(724-726)Tac>Aac	p.Y242N	MFSD2B_ENST00000406420.3_Missense_Mutation_p.Y242N			A6NFX1	MFS2B_HUMAN	major facilitator superfamily domain containing 2B	242					transport	integral to membrane				cervix(2)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)	10						TGTAGTGACTTACCCCGTGTG	0.592000													4	24					0	0	1	0	0
PSME4	23198	broad.mit.edu	37	2	54167126	54167126	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:54167126T>C	ENST00000404125.1	-	4	567	c.512A>G	c.(511-513)aAt>aGt	p.N171S	PSME4_ENST00000421748.2_Intron	NM_014614.2	NP_055429.2	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator subunit 4	171					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			breast(5)|endometrium(8)|kidney(1)|large_intestine(11)|lung(26)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(2)	60			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TTTGAGAATATTTTCTACAGA	0.348000													41	122					0	0	1	0	0
RHOA	387	broad.mit.edu	37	3	49405912	49405912	+	Missense_Mutation	SNP	C	C	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:49405912C>A	ENST00000418115.1	-	3	610	c.226G>T	c.(226-228)Gat>Tat	p.D76Y	RHOA_ENST00000454011.2_Intron|RHOA_ENST00000422781.1_Missense_Mutation_p.D76Y	NM_001664.2	NP_001655.1	P61586	RHOA_HUMAN	ras homolog family member A	76					axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding	p.D76N(1)		cervix(1)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	12				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	ACATCGGTATCTGGGTAGGAG	0.493000													48	56					8.00217e-19	8.51589e-19	1	1	0
MAN1A2	10905	broad.mit.edu	37	1	117944854	117944854	+	Nonsense_Mutation	SNP	A	A	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:117944854A>T	ENST00000356554.3	+	2	1084	c.349A>T	c.(349-351)Aag>Tag	p.K117*	MAN1A2_ENST00000482811.1_Intron	NM_006699.3	NP_006690.1	O60476	MA1A2_HUMAN	mannosidase, alpha, class 1A, member 2	117					N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|urinary_tract(1)	27	Lung SC(450;0.225)	all_cancers(81;7.9e-06)|all_epithelial(167;7.39e-07)|all_lung(203;2.84e-06)|Lung NSC(69;1.99e-05)		Lung(183;0.0688)|Kidney(133;0.114)|LUSC - Lung squamous cell carcinoma(189;0.223)|KIRC - Kidney renal clear cell carcinoma(1967;0.237)|Colorectal(144;0.243)		TGATCATGAGAAGGCCTTGGA	0.363000													22	61					0	0	1	0	0
PMEPA1	56937	broad.mit.edu	37	20	56227370	56227370	+	Missense_Mutation	SNP	C	C	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr20:56227370C>A	ENST00000341744.3	-	4	922	c.603G>T	c.(601-603)agG>agT	p.R201S	PMEPA1_ENST00000265626.4_Missense_Mutation_p.R151S|PMEPA1_ENST00000395816.3_Missense_Mutation_p.R151S|PMEPA1_ENST00000347215.4_Missense_Mutation_p.R166S|PMEPA1_ENST00000395814.1_Missense_Mutation_p.R151S	NM_020182.4	NP_064567.2	Q969W9	PMEPA_HUMAN	prostate transmembrane protein, androgen induced 1	201					androgen receptor signaling pathway	integral to membrane|plasma membrane	WW domain binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)	16						GGCCGCCCAGCCTGGCACTAT	0.687000													12	41					7.03913e-09	7.27545e-09	1	1	0
EIF3D	8664	broad.mit.edu	37	22	36913461	36913461	+	Nonsense_Mutation	SNP	C	C	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr22:36913461C>A	ENST00000216190.8	-	10	1247	c.877G>T	c.(877-879)Gag>Tag	p.E293*	EIF3D_ENST00000405442.1_Nonsense_Mutation_p.E293*|EIF3D_ENST00000541106.1_Nonsense_Mutation_p.E244*	NM_003753.3	NP_003744.1	O15371	EIF3D_HUMAN	eukaryotic translation initiation factor 3, subunit D	293						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			cervix(1)|endometrium(2)|large_intestine(6)|lung(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	15						TTGGCAGTCTCACTCACTGTC	0.532000													11	15					9.31168e-06	9.51027e-06	1	1	0
NLRC5	84166	broad.mit.edu	37	16	57113485	57113485	+	Missense_Mutation	SNP	G	G	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr16:57113485G>T	ENST00000262510.6	+	46	5490	c.5265G>T	c.(5263-5265)caG>caT	p.Q1755H	NLRC5_ENST00000308149.7_Missense_Mutation_p.Q1726H|NLRC5_ENST00000539144.1_Missense_Mutation_p.Q1726H|NLRC5_ENST00000436936.1_3'UTR	NM_032206.4	NP_115582.4	Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	1755					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				TTGACAACCAGACTGCCAAGC	0.557000													27	59					6.32553e-13	6.68212e-13	1	1	0
TPRN	286262	broad.mit.edu	37	9	140087130	140087130	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr9:140087130A>G	ENST00000409012.4	-	2	1825	c.1739T>C	c.(1738-1740)tTc>tCc	p.F580S	TPRN_ENST00000541945.1_5'UTR|TPRN_ENST00000321773.2_Missense_Mutation_p.F519S	NM_001128228.2	NP_001121700.2	Q4KMQ1	TPRN_HUMAN	taperin	580					sensory perception of sound	stereocilium				breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)	8						TTTGTCGTTGAAGGAGATCTT	0.587000													17	37					0	0	1	0	0
TEX10	54881	broad.mit.edu	37	9	103090114	103090114	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr9:103090114T>C	ENST00000374902.4	-	8	1932	c.1756A>G	c.(1756-1758)Aaa>Gaa	p.K586E	TEX10_ENST00000535814.1_Missense_Mutation_p.K589E	NM_017746.3	NP_060216.2	Q9NXF1	TEX10_HUMAN	testis expressed 10	586						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			NS(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	38		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		AGTAATTCTTTATTTGCTCGT	0.418000													29	61					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108137961	108137961	+	Missense_Mutation	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr11:108137961G>C	ENST00000278616.4	+	17	2915	c.2530G>C	c.(2530-2532)Gga>Cga	p.G844R	ATM_ENST00000452508.2_Missense_Mutation_p.G844R	NM_000051.3	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	844					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TGATACTAATGGAAATCTAAT	0.403000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			14	20					0	0	1	0	0
MAP4K5	11183	broad.mit.edu	37	14	50907139	50907139	+	Missense_Mutation	SNP	T	T	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr14:50907139T>G	ENST00000013125.4	-	22	1903	c.1585A>C	c.(1585-1587)Act>Cct	p.T529P		NM_006575.4|NM_198794.2	NP_006566.2|NP_942089.1	Q9Y4K4	M4K5_HUMAN	mitogen-activated protein kinase kinase kinase kinase 5	529	CNH.				activation of JUN kinase activity	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15	all_epithelial(31;0.000415)|Breast(41;0.0102)					CCATCTTCAGTTCCAAAAATA	0.289000													4	5					0	0	1	0	0
ANKRD36BP2	645784	broad.mit.edu	37	2	89082382	89082382	+	RNA	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:89082382G>A	ENST00000393525.3	+	0	516																											TGCAAGTGACGAGAAAGATTC	0.338000													12	44					0	0	1	0	0
TRIM39	56658	broad.mit.edu	37	6	30309568	30309568	+	Missense_Mutation	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr6:30309568G>C	ENST00000376659.5	+	8	1597	c.999G>C	c.(997-999)gaG>gaC	p.E333D	TRIM39_ENST00000396551.3_Missense_Mutation_p.E333D|TRIM39_ENST00000376656.4_Missense_Mutation_p.E363D|TRIM39-RPP21_ENST00000513556.1_Missense_Mutation_p.E245D|TRIM39_ENST00000540416.1_Missense_Mutation_p.E333D|TRIM39_ENST00000396547.1_Missense_Mutation_p.E363D|TRIM39_ENST00000396548.1_Missense_Mutation_p.E333D	NM_172016.2	NP_742013.1			tripartite motif containing 39											ovary(3)	3						AGTTCGTGGAGACAAGACTCC	0.572000													8	36					0	0	1	0	0
DOT1L	84444	broad.mit.edu	37	19	2226955	2226955	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:2226955A>G	ENST00000398665.3	+	27	4471	c.4435A>G	c.(4435-4437)Atg>Gtg	p.M1479V		NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase	1479						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTCGGCCCCATGTCCCTGCA	0.756000													4	14					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33154397	33154397	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr6:33154397C>G	ENST00000395194.1	-	5	1018	c.805G>C	c.(805-807)Gag>Cag	p.E269Q	COL11A2_ENST00000374712.1_Intron|COL11A2_ENST00000374714.1_Intron|COL11A2_ENST00000395197.1_Intron|COL11A2_ENST00000374713.1_Intron|COL11A2_ENST00000357486.1_Intron|COL11A2_ENST00000361917.1_Intron|COL11A2_ENST00000341947.2_Intron|COL11A2_ENST00000374708.4_Intron	NM_001163771.1	NP_001157243.1	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	269	Nonhelical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						TCTCCCAGCTCCCTCACCTGG	0.572000													20	83					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37431011	37431011	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr10:37431011A>G	ENST00000374660.1	+	7	1117	c.1018A>G	c.(1018-1020)Atg>Gtg	p.M340V	ANKRD30A_ENST00000361713.1_Missense_Mutation_p.M340V|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.M340V			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	396						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						TAGGGAAATTATGAGTCCCGC	0.433000													35	136					0	0	1	0	0
BCL2L13	23786	broad.mit.edu	37	22	18209913	18209913	+	Silent	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr22:18209913A>G	ENST00000317582.5	+	7	1418	c.1071A>G	c.(1069-1071)acA>acG	p.T357T	BCL2L13_ENST00000485631.1_3'UTR|BCL2L13_ENST00000418951.2_3'UTR|BCL2L13_ENST00000355028.3_3'UTR|BCL2L13_ENST00000538149.1_Silent_p.T233T|BCL2L13_ENST00000337612.5_Silent_p.T195T|BCL2L13_ENST00000543133.1_Silent_p.T195T	NM_015367.3	NP_056182.2	Q9BXK5	B2L13_HUMAN	BCL2-like 13 (apoptosis facilitator)	357	Glu-rich.				induction of apoptosis	integral to membrane|mitochondrial membrane|nucleus	caspase activator activity			breast(2)|central_nervous_system(1)|large_intestine(2)|liver(2)|lung(2)|ovary(1)|skin(3)|urinary_tract(2)	15		all_epithelial(15;0.123)		Lung(27;0.199)		TGCTGGGGACAAGGGAACCTG	0.532000													14	47					0	0	1	0	0
RFC2	5982	broad.mit.edu	37	7	73646462	73646462	+	Nonsense_Mutation	SNP	T	T	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr7:73646462T>A	ENST00000055077.3	-	11	1099	c.1039A>T	c.(1039-1041)Aag>Tag	p.K347*	RFC2_ENST00000352131.3_Nonsense_Mutation_p.K313*	NM_181471.1	NP_852136.1	P35250	RFC2_HUMAN	replication factor C (activator 1) 2, 40kDa	347					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(3)	8						GCCATTGTCTTCTGACACAGC	0.507000													38	66					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179451515	179451515	+	Missense_Mutation	SNP	C	C	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:179451515C>A	ENST00000589042.1	-	308	64337	c.64113G>T	c.(64111-64113)agG>agT	p.R21371S	TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000590743.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R12431S|TTN_ENST00000460472.2_Missense_Mutation_p.R12306S|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R18803S|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R12498S|TTN_ENST00000591111.1_Missense_Mutation_p.R19730S	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19730	Ig-like 113.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTCTAATTTCCTTGGGGGAT	0.408000													23	34					5.45024e-15	5.78585e-15	1	1	0
ESPL1	9700	broad.mit.edu	37	12	53663771	53663771	+	Nonsense_Mutation	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:53663771C>T	ENST00000257934.4	+	3	1136	c.1045C>T	c.(1045-1047)Cga>Tga	p.R349*	ESPL1_ENST00000552462.1_Nonsense_Mutation_p.R349*	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	349					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						AGGCCTGGAACGAGGCACCAA	0.537000													19	42					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32828145	32828145	+	Missense_Mutation	SNP	T	T	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:32828145T>A	ENST00000421745.2	+	71	14199	c.14065T>A	c.(14065-14067)Ttg>Atg	p.L4689M		NM_016252.3	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	4689	Ubiquitin-conjugating.				anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					CTCAAGCTTTTTGCAAGTAAA	0.323000													17	35					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189608585	189608585	+	Missense_Mutation	SNP	G	G	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:189608585G>T	ENST00000264731.3	+	13	1749	c.1660G>T	c.(1660-1662)Gcg>Tcg	p.A554S	TP63_ENST00000354600.5_Missense_Mutation_p.A460S|TP63_ENST00000392460.3_Intron|TP63_ENST00000382063.4_Missense_Mutation_p.A469S|TP63_ENST00000440651.2_Missense_Mutation_p.A550S|TP63_ENST00000449992.1_Missense_Mutation_p.A375S|TP63_ENST00000320472.5_Intron|TP63_ENST00000392461.3_Intron|TP63_ENST00000456148.1_Missense_Mutation_p.A456S|TP63_ENST00000392463.2_Intron	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	554	SAM.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CAGTTTCTTAGCGAGGTTGGG	0.453000										HNSCC(45;0.13)			22	39					3.62473e-10	3.77357e-10	1	1	0
GTF3C1	2975	broad.mit.edu	37	16	27518206	27518206	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr16:27518206C>G	ENST00000356183.4	-	9	1529	c.1514G>C	c.(1513-1515)cGg>cCg	p.R505P	GTF3C1_ENST00000561623.1_Missense_Mutation_p.R505P	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	505						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						GGTCTTGGGCCGGAGGTTTGC	0.622000													6	12					0	0	1	0	0
SUZ12	23512	broad.mit.edu	37	17	30321706	30321706	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr17:30321706A>G	ENST00000322652.5	+	13	1790	c.1561A>G	c.(1561-1563)Aag>Gag	p.K521E	SUZ12_ENST00000580398.1_Missense_Mutation_p.K498E	NM_015355.2	NP_056170.2	Q15022	SUZ12_HUMAN	SUZ12 polycomb repressive complex 2 subunit	521					negative regulation of cell differentiation|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|methylated histone residue binding|zinc ion binding		SSH2/SUZ12(2)|JAZF1/SUZ12(133)	breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|lung(5)|skin(1)	21		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.041)|Ovarian(249;0.182)|Breast(31;0.231)				CGGACCAGTTAAGAGAACACC	0.398000			T	JAZF1	endometrial stromal tumours								45	54					0	0	1	0	0
ATL1	51062	broad.mit.edu	37	14	51080022	51080022	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr14:51080022T>C	ENST00000441560.2	+	8	1157	c.676T>C	c.(676-678)Tca>Cca	p.S226P	ATL1_ENST00000357032.3_Missense_Mutation_p.S226P|ATL1_ENST00000354525.4_Missense_Mutation_p.S226P|ATL1_ENST00000358385.6_Missense_Mutation_p.S226P	NM_001127713.1	NP_001121185.1	Q8WXF7	ATLA1_HUMAN	atlastin GTPase 1	226					axonogenesis|cell death|endoplasmic reticulum organization|protein homooligomerization	axon|endoplasmic reticulum membrane|Golgi cis cisterna|Golgi membrane|integral to membrane|microsome	GTP binding|GTPase activity|identical protein binding			central_nervous_system(1)|cervix(2)|large_intestine(4)|liver(1)|lung(6)|ovary(1)|skin(3)	18						ATACGAATTTTCATATGGAGC	0.363000													35	58					0	0	1	0	0
SLC22A12	116085	broad.mit.edu	37	11	64366378	64366378	+	Silent	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr11:64366378T>C	ENST00000377574.1	+	6	1800	c.1053T>C	c.(1051-1053)tgT>tgC	p.C351C	SLC22A12_ENST00000336464.7_Silent_p.C317C|SLC22A12_ENST00000377572.1_Silent_p.C243C|SLC22A12_ENST00000473690.1_Silent_p.C130C|SLC22A12_ENST00000377567.2_Silent_p.C243C	NM_144585.2	NP_653186.2	Q96S37	S22AC_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 12	351					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27						TCCGGACCTGTATCTCCACGT	0.667000													6	13					0	0	1	0	0
LRAT	9227	broad.mit.edu	37	4	155670140	155670140	+	Missense_Mutation	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr4:155670140G>C	ENST00000336356.3	+	3	798	c.545G>C	c.(544-546)tGt>tCt	p.C182S	LRAT_ENST00000507827.1_Missense_Mutation_p.C182S	NM_004744.3	NP_004735.2	O95237	LRAT_HUMAN	lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)	182					response to stimulus|retinoid metabolic process|steroid metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|multivesicular body|perinuclear region of cytoplasm|rough endoplasmic reticulum	phosphatidylcholine-retinol O-acyltransferase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)	16	all_hematologic(180;0.215)	Renal(120;0.0458)			Vitamin A(DB00162)	TTCCAGTTTTGTGAGACTGTG	0.373000													17	47					0	0	1	0	0
RBPJL	11317	broad.mit.edu	37	20	43945386	43945386	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr20:43945386C>G	ENST00000372741.3	+	12	1423	c.1351C>G	c.(1351-1353)Ctg>Gtg	p.L451V	RBPJL_ENST00000464504.1_3'UTR|RBPJL_ENST00000372743.1_Silent_p.R446R|RBPJL_ENST00000343694.3_Silent_p.R447R			Q9UBG7	RBPJL_HUMAN	recombination signal binding protein for immunoglobulin kappa J region-like	0	IPT/TIG.				signal transduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|kidney(1)|large_intestine(5)|lung(3)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Myeloproliferative disorder(115;0.0122)				GCGACTGGCGCTGGCTGCGCG	0.692000													6	20					0	0	1	0	0
MAN2B2	23324	broad.mit.edu	37	4	6578377	6578377	+	Missense_Mutation	SNP	C	C	G	rs138166132		TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr4:6578377C>G	ENST00000285599.3	+	2	247	c.211C>G	c.(211-213)Cgg>Ggg	p.R71G	MAN2B2_ENST00000504248.1_Missense_Mutation_p.R71G	NM_015274.1	NP_056089.1	Q9Y2E5	MA2B2_HUMAN	mannosidase, alpha, class 2B, member 2	71					mannose metabolic process	extracellular region	alpha-mannosidase activity|carbohydrate binding|zinc ion binding			breast(2)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(9)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	30						CCAGCAGCGCCGGTTCATCGC	0.622000													27	46					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144912277	144912277	+	Silent	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:144912277C>T	ENST00000529945.1	-	11	2926	c.2487G>A	c.(2485-2487)ttG>ttA	p.L829L	PDE4DIP_ENST00000369349.3_Silent_p.L666L|PDE4DIP_ENST00000479408.2_Silent_p.L453L|PDE4DIP_ENST00000530740.1_Silent_p.L803L|PDE4DIP_ENST00000313431.9_Silent_p.L829L|PDE4DIP_ENST00000369354.3_Silent_p.L666L|PDE4DIP_ENST00000369356.4_Silent_p.L666L|PDE4DIP_ENST00000369351.3_Silent_p.L666L|PDE4DIP_ENST00000313382.9_Silent_p.L732L|PDE4DIP_ENST00000369359.4_Silent_p.L803L			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	666					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		AGGCTTGCACCAACTTCTCTG	0.388000			T	PDGFRB	MPD								9	63					0	0	1	0	0
CMIP	80790	broad.mit.edu	37	16	81725418	81725418	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr16:81725418T>C	ENST00000537098.3	+	11	1499	c.1427T>C	c.(1426-1428)tTg>tCg	p.L476S	CMIP_ENST00000539778.2_Missense_Mutation_p.L382S|CMIP_ENST00000398040.4_Missense_Mutation_p.L323S|CMIP_ENST00000566513.1_3'UTR	NM_198390.2	NP_938204.2	Q8IY22	CMIP_HUMAN	c-Maf inducing protein	442						cytoplasm|nucleus				endometrium(5)|kidney(1)|lung(7)	13						CTGGCCAGTTTGCTTCAACCC	0.522000													8	12					0	0	1	0	0
KIAA1009	22832	broad.mit.edu	37	6	84930886	84930886	+	Missense_Mutation	SNP	A	A	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr6:84930886A>C	ENST00000403245.3	-	3	175	c.61T>G	c.(61-63)Tca>Gca	p.S21A	KIAA1009_ENST00000257766.4_5'UTR	NM_014895.2	NP_055710.2	Q5TB80	QN1_HUMAN	KIAA1009	21					cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(17)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	43		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		GAATCATCTGAAAGCTGAATT	0.308000													31	12					0	0	1	0	0
GPR12	2835	broad.mit.edu	37	13	27333761	27333761	+	Silent	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr13:27333761G>A	ENST00000405846.3	-	2	425	c.204C>T	c.(202-204)atC>atT	p.I68I	GPR12_ENST00000381436.2_Silent_p.I68I	NM_005288.3	NP_005279.1	P47775	GPR12_HUMAN	G protein-coupled receptor 12	68						integral to plasma membrane				endometrium(7)|kidney(2)|large_intestine(6)|lung(14)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33	Colorectal(5;5.77e-05)	Breast(139;0.198)		Epithelial(112;9.37e-07)|OV - Ovarian serous cystadenocarcinoma(117;1.16e-06)|all cancers(112;8.31e-06)|GBM - Glioblastoma multiforme(144;0.00121)|Lung(94;0.111)|LUSC - Lung squamous cell carcinoma(192;0.184)		TGTGGAAGATGATAAGGACCA	0.547000													25	39					0	0	1	0	0
STRN3	29966	broad.mit.edu	37	14	31364787	31364787	+	Splice_Site	SNP	C	C	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr14:31364787C>A	ENST00000355683.5	-	16	2188		c.e16-1		STRN3_ENST00000357479.5_Splice_Site	NM_014574.3	NP_055389.3	Q13033	STRN3_HUMAN	striatin, calmodulin binding protein 3						negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		CAGTCATGGCCTGTAAAAGAA	0.328000													18	29					2.35188e-11	2.47234e-11	1	1	0
ZNRF4	148066	broad.mit.edu	37	19	5455685	5455685	+	Missense_Mutation	SNP	C	C	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:5455685C>A	ENST00000222033.4	+	1	260	c.183C>A	c.(181-183)agC>agA	p.S61R		NM_181710.3	NP_859061.3	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4	61						integral to membrane	zinc ion binding			NS(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		TGGGACCTAGCAGCACACAGA	0.667000													15	38					1.5739e-10	1.64249e-10	1	1	0
ZNF492	57615	broad.mit.edu	37	19	22847052	22847052	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:22847052A>G	ENST00000456783.2	+	4	825	c.581A>G	c.(580-582)aAg>aGg	p.K194R		NM_020855.2	NP_065906.1	Q9P255	ZN492_HUMAN	zinc finger protein 492	194					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				CATACTGGAAAGAAACCCTAC	0.373000													10	16					0	0	1	0	0
C3orf30	152405	broad.mit.edu	37	3	118865235	118865235	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:118865235A>G	ENST00000295622.1	+	1	239	c.199A>G	c.(199-201)Ata>Gta	p.I67V		NM_152539.2	NP_689752.2	Q96M34	CC030_HUMAN	chromosome 3 open reading frame 30	67										NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(20)|ovary(2)|prostate(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(114;0.222)		TGAATCCAGCATATTTAGCCA	0.527000													14	13					0	0	1	0	0
MTA2	9219	broad.mit.edu	37	11	62362073	62362073	+	Missense_Mutation	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr11:62362073C>T	ENST00000278823.2	-	16	1996	c.1607G>A	c.(1606-1608)cGg>cAg	p.R536Q	MTA2_ENST00000527204.1_Missense_Mutation_p.R363Q|MTA2_ENST00000524902.1_Missense_Mutation_p.R363Q	NM_004739.3	NP_004730.2	O94776	MTA2_HUMAN	metastasis associated 1 family, member 2	536					chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	26						CTTGGTACCCCGAGGTGTTTT	0.512000													20	46					0	0	1	0	0
HRASLS5	117245	broad.mit.edu	37	11	63233640	63233640	+	Missense_Mutation	SNP	T	T	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr11:63233640T>A	ENST00000540857.1	-	5	791	c.659A>T	c.(658-660)gAa>gTa	p.E220V	HRASLS5_ENST00000301790.4_Missense_Mutation_p.E230V|HRASLS5_ENST00000539221.1_Missense_Mutation_p.E230V	NM_001146728.1|NM_001146729.1|NM_054108.3	NP_001140200.1|NP_001140201|NP_473449.1	Q96KN8	HRSL5_HUMAN	HRAS-like suppressor family, member 5	230										endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|urinary_tract(1)	14						ACAGTTCCCTTCAATCAGGCT	0.507000													23	42					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55107356	55107356	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:55107356C>G	ENST00000251372.3	+	6	1096	c.914C>G	c.(913-915)tCc>tGc	p.S305C	LILRA1_ENST00000473156.1_3'UTR|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000396321.2_Intron|LILRA1_ENST00000453777.1_Intron|LILRB1_ENST00000448689.1_Intron	NM_006863.2	NP_006854.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	305	Ig-like C2-type 3.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		AACCTCTCCTCCGAGTGGTCG	0.682000													12	56					0	0	1	0	0
FAM171B	165215	broad.mit.edu	37	2	187626418	187626418	+	Missense_Mutation	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:187626418G>C	ENST00000304698.5	+	8	1552	c.1349G>C	c.(1348-1350)aGa>aCa	p.R450T		NM_177454.3	NP_803237.3	Q6P995	F171B_HUMAN	family with sequence similarity 171, member B	450						integral to membrane	DNA binding			NS(1)|breast(6)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(22)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						ACAGAAGAAAGAGTTTCCATG	0.358000													24	30					0	0	1	0	0
DMBX1	127343	broad.mit.edu	37	1	46976766	46976766	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:46976766C>G	ENST00000371956.4	+	3	523	c.508C>G	c.(508-510)Ctg>Gtg	p.L170V	DMBX1_ENST00000360032.3_Missense_Mutation_p.L165V	NM_147192.2	NP_671725.1	Q8NFW5	DMBX1_HUMAN	diencephalon/mesencephalon homeobox 1	170					brain development|developmental growth|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Acute lymphoblastic leukemia(166;0.155)					GCCCCCACGTCTGCCTGGCAG	0.657000													13	59					0	0	1	0	0
SCAF11	9169	broad.mit.edu	37	12	46320208	46320208	+	Silent	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:46320208C>T	ENST00000465950.1	-	1	3540	c.2331G>A	c.(2329-2331)caG>caA	p.Q777Q	SCAF11_ENST00000369367.3_Silent_p.Q1092Q|SCAF11_ENST00000419565.2_Silent_p.Q1092Q|SCAF11_ENST00000549162.1_Silent_p.Q900Q			Q99590	SCAFB_HUMAN	SR-related CTD-associated factor 11	1092					spliceosome assembly	nucleus	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						GATTTTCATTCTGATCTTTAT	0.433000													25	52					0	0	1	0	0
STAT4	6775	broad.mit.edu	37	2	191934453	191934453	+	Missense_Mutation	SNP	T	T	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:191934453T>G	ENST00000392320.2	-	6	824	c.510A>C	c.(508-510)gaA>gaC	p.E170D	STAT4_ENST00000358470.4_Missense_Mutation_p.E170D	NM_003151.3	NP_003142.1	Q14765	STAT4_HUMAN	signal transducer and activator of transcription 4	170					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(4)|endometrium(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			TGTAGTCAAATTCGTCTTGCA	0.323000													30	52					0	0	1	0	0
DMXL2	23312	broad.mit.edu	37	15	51837962	51837962	+	Splice_Site	SNP	C	C	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr15:51837962C>A	ENST00000251076.5	-	8	1035	c.748G>T	c.(748-750)Ggt>Tgt	p.G250C	DMXL2_ENST00000543779.2_Splice_Site_p.G250C|DMXL2_ENST00000449909.3_Splice_Site_p.G250C	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	250						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		CAGACAGAACCCCTAACAACA	0.353000													38	92					3.78316e-11	3.96725e-11	1	1	0
GDAP1L1	78997	broad.mit.edu	37	20	42891922	42891922	+	Missense_Mutation	SNP	G	G	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr20:42891922G>T	ENST00000342560.5	+	4	688	c.600G>T	c.(598-600)gaG>gaT	p.E200D	GDAP1L1_ENST00000537864.1_Missense_Mutation_p.E8D	NM_001256737.1|NM_024034.4	NP_001243666.1|NP_076939.3	Q96MZ0	GD1L1_HUMAN	ganglioside induced differentiation associated protein 1-like 1	200	GST C-terminal.									endometrium(1)|large_intestine(5)|lung(10)|pancreas(1)|prostate(1)	18		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			ATGAAGAGGAGCCCCAGCTCT	0.532000													47	169					5.7616e-29	6.23932e-29	1	1	0
MUC5B	727897	broad.mit.edu	37	11	1272743	1272743	+	Missense_Mutation	SNP	A	A	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr11:1272743A>C	ENST00000447027.1	+	31	14700	c.14642A>C	c.(14641-14643)aAa>aCa	p.K4881T	MUC5B_ENST00000529681.1_Missense_Mutation_p.K4878T			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4878	Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CACACCCCCAAAGTGGTGACC	0.657000													12	24					0	0	1	0	0
SYK	6850	broad.mit.edu	37	9	93606295	93606295	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr9:93606295T>C	ENST00000375754.4	+	2	263	c.115T>C	c.(115-117)Tat>Cat	p.Y39H	SYK_ENST00000476708.1_3'UTR|SYK_ENST00000375747.1_Missense_Mutation_p.Y39H|SYK_ENST00000375751.4_Missense_Mutation_p.Y39H|SYK_ENST00000375746.1_Missense_Mutation_p.Y39H	NM_003177.5	NP_003168.2	P43405	KSYK_HUMAN	spleen tyrosine kinase	39	SH2 1.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)|skin(2)|stomach(2)	26						TGATGGGCTTTATTTGCTGCG	0.612000			T	"""ETV6, ITK"""	"""MDS, peripheral T-cell lymphoma"""								15	9					0	0	1	0	0
ANXA2R	389289	broad.mit.edu	37	5	43040037	43040037	+	Missense_Mutation	SNP	G	G	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr5:43040037G>T	ENST00000314890.3	-	2	1531	c.112C>A	c.(112-114)Ctt>Att	p.L38I		NM_001014279.2	NP_001014301.1	Q3ZCQ2	AX2R_HUMAN	annexin A2 receptor	38							receptor activity										TACAAAGGAAGAGGCCACGGC	0.567000											OREG0016598	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	61					1.08611e-07	1.11721e-07	1	1	0
TFG	10342	broad.mit.edu	37	3	100467057	100467057	+	Silent	SNP	A	A	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:100467057A>T	ENST00000240851.4	+	8	1225	c.885A>T	c.(883-885)ccA>ccT	p.P295P	TFG_ENST00000476228.1_Silent_p.P291P|TFG_ENST00000481203.1_3'UTR|TFG_ENST00000490574.1_Silent_p.P295P|TFG_ENST00000418917.2_Silent_p.P291P	NM_001195478.1|NM_001195479.1|NM_006070.5	NP_001182407.1|NP_001182408.1|NP_006061.2	Q92734	TFG_HUMAN	TRK-fused gene	295					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm	signal transducer activity		TFG/NR4A3(2)|TFG/NTRK1_ENST00000392302(5)|TFG/ALK(9)	large_intestine(4)|lung(2)|prostate(1)|stomach(1)	8						GCCAGCAACCAACTTCCCAGG	0.493000			T	"""NTRK1, ALK"""	"""papillary thyroid, ALCL, NSCLC"""								11	71					0	0	1	0	0
DCUN1D2	55208	broad.mit.edu	37	13	114134914	114134914	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr13:114134914A>G	ENST00000478244.1	-	3	647	c.365T>C	c.(364-366)tTt>tCt	p.F122S	DCUN1D2_ENST00000460318.1_5'UTR|DCUN1D2_ENST00000332592.3_Intron|DCUN1D2_ENST00000375399.2_Missense_Mutation_p.F122S	NM_001014283.1	NP_001014305.1	Q6PH85	DCNL2_HUMAN	DCN1, defective in cullin neddylation 1, domain containing 2	122	DCUN1.									breast(1)|endometrium(1)|large_intestine(1)|lung(3)|stomach(1)	7	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.029)|GBM - Glioblastoma multiforme(44;0.234)			GCCATCTAGAAATTCCTTTCT	0.383000													3	80					0	0	1	0	0
AMER2	219287	broad.mit.edu	37	13	25744214	25744214	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr13:25744214T>C	ENST00000357816.2	-	3	1662	c.1187A>G	c.(1186-1188)gAa>gGa	p.E396G	AMER2_ENST00000381853.3_Missense_Mutation_p.E396G|AMER2_ENST00000515384.1_Missense_Mutation_p.E515G					APC membrane recruitment protein 2																		GGGGACGCCTTCCTGCTGCTC	0.662000													5	48					0	0	1	0	0
CYP11B2	1585	broad.mit.edu	37	8	143996274	143996274	+	Missense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr8:143996274G>A	ENST00000323110.2	-	4	648	c.646C>T	c.(646-648)Ccc>Tcc	p.P216S		NM_000498.3	NP_000489.3	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 2	216					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity			cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(22)|ovary(3)|upper_aerodigestive_tract(3)	39	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	GCAGAACTGGGGCTGTGGCCA	0.612000									Familial Hyperaldosteronism type I				11	6					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19470510	19470510	+	Missense_Mutation	SNP	T	T	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:19470510T>G	ENST00000375267.2	-	55	8146	c.8143A>C	c.(8143-8145)Act>Cct	p.T2715P	UBR4_ENST00000375226.2_Missense_Mutation_p.T2726P|UBR4_ENST00000375217.2_Missense_Mutation_p.T2743P|UBR4_ENST00000375254.3_Missense_Mutation_p.T2715P			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	2715					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GAGGGTAAAGTCACATGTCTC	0.488000													28	59					0	0	1	0	0
ZBED4	9889	broad.mit.edu	37	22	50278127	50278127	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr22:50278127A>G	ENST00000216268.5	+	2	1294	c.817A>G	c.(817-819)Aag>Gag	p.K273E		NM_014838.2	NP_055653.2	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4							cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		CTTAGCGGAGAAGAGCCTTCC	0.572000													26	48					0	0	1	0	0
CLK1	1195	broad.mit.edu	37	2	201722792	201722792	+	Missense_Mutation	SNP	A	A	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:201722792A>C	ENST00000434813.2	-	6	1029	c.695T>G	c.(694-696)gTa>gGa	p.V232G	CLK1_ENST00000321356.4_Missense_Mutation_p.V190G|CLK1_ENST00000409769.2_Missense_Mutation_p.V13G	NM_001162407.1	NP_001155879.1	P49759	CLK1_HUMAN	CDC-like kinase 1	190	Protein kinase.				cell proliferation	nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			NS(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(12)|ovary(1)|pancreas(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	33						AACTATTTTTACTGCTACATG	0.373000													31	52					0	0	1	0	0
MRPL32	64983	broad.mit.edu	37	7	42977014	42977014	+	Missense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr7:42977014G>A	ENST00000223324.2	+	3	593	c.406G>A	c.(406-408)Gaa>Aaa	p.E136K	MRPL32_ENST00000496564.1_Intron	NM_031903.2	NP_114109.1	Q9BYC8	RM32_HUMAN	mitochondrial ribosomal protein L32	136					translation	large ribosomal subunit|mitochondrial ribosome	structural constituent of ribosome			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)	10						GGAGACTGCAGAAATCAGACG	0.473000													41	34					0	0	1	0	0
WIPI2	26100	broad.mit.edu	37	7	5256811	5256811	+	Missense_Mutation	SNP	T	T	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr7:5256811T>G	ENST00000288828.4	+	6	801	c.569T>G	c.(568-570)aTt>aGt	p.I190S	WIPI2_ENST00000484262.1_Missense_Mutation_p.I131S|WIPI2_ENST00000404704.3_Missense_Mutation_p.I190S|WIPI2_ENST00000382384.2_Missense_Mutation_p.I172S|WIPI2_ENST00000401525.3_Missense_Mutation_p.I172S	NM_001033518.1|NM_001278299.1|NM_015610.3	NP_001028690.1|NP_001265228.1|NP_056425.1	Q9Y4P8	WIPI2_HUMAN	WD repeat domain, phosphoinositide interacting 2	190					autophagic vacuole assembly	cytosol|PAS complex|pre-autophagosomal structure membrane	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)	16		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0925)|OV - Ovarian serous cystadenocarcinoma(56;2.59e-14)		TTCGATACCATTAATTTGGTG	0.522000													45	36					0	0	1	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29973250	29973250	+	Silent	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chrX:29973250T>C	ENST00000378993.1	+	11	2077	c.1404T>C	c.(1402-1404)gaT>gaC	p.D468D	IL1RAPL1_ENST00000302196.4_Silent_p.D468D	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	468	TIR.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						GATGTGTAGATCAAAGCAAGC	0.398000													22	48					0	0	1	0	0
CC2D1B	200014	broad.mit.edu	37	1	52824934	52824934	+	Missense_Mutation	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:52824934G>C	ENST00000371586.2	-	10	1252	c.1114C>G	c.(1114-1116)Cca>Gca	p.P372A	CC2D1B_ENST00000460261.1_5'UTR|CC2D1B_ENST00000284376.3_Missense_Mutation_p.P372A|CC2D1B_ENST00000438831.1_5'UTR	NM_032449.2	NP_115825.1	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	372										breast(1)|large_intestine(6)|lung(13)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	27						GGGGTTGCTGGGACGTCAGGG	0.632000													11	30					0	0	1	0	0
ZBTB22	9278	broad.mit.edu	37	6	33283928	33283928	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr6:33283928T>C	ENST00000431845.2	-	2	917	c.766A>G	c.(766-768)Aag>Gag	p.K256E	ZBTB22_ENST00000418724.1_Missense_Mutation_p.K256E	NM_005453.4	NP_005444.4	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	256					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(3)	21						AGCAGCAGCTTTCCAGATGTG	0.647000													11	34					0	0	1	0	0
FOLH1	2346	broad.mit.edu	37	11	49221949	49221949	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr11:49221949A>G	ENST00000340334.7	-	4	592	c.224T>C	c.(223-225)tTt>tCt	p.F75S	FOLH1_ENST00000356696.3_Missense_Mutation_p.F90S|FOLH1_ENST00000343844.4_Intron|FOLH1_ENST00000533034.1_Missense_Mutation_p.F75S|FOLH1_ENST00000256999.2_Missense_Mutation_p.F90S	NM_001193471.1|NM_001193472.1	NP_001180400.1|NP_001180401.1	Q04609	FOLH1_HUMAN	folate hydrolase (prostate-specific membrane antigen) 1	90			Y -> H (in dbSNP:rs202676).		proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(34)|ovary(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	60					Capromab(DB00089)|L-Glutamic Acid(DB00142)	TGCAAGCTGAAAGTTTTGTTC	0.353000													5	14					0	0	1	0	0
ATP4A	495	broad.mit.edu	37	19	36050019	36050019	+	Silent	SNP	T	T	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:36050019T>G	ENST00000262623.3	-	8	1159	c.1131A>C	c.(1129-1131)acA>acC	p.T377T		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	377					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	TGGAGCCCAATGTCTCCACCG	0.592000													64	240					0	0	1	0	0
ASIC4	55515	broad.mit.edu	37	2	220397182	220397182	+	Missense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:220397182G>A	ENST00000358078.4	+	4	1396	c.1382G>A	c.(1381-1383)cGg>cAg	p.R461Q	ASIC4_ENST00000347842.3_Missense_Mutation_p.R461Q|ASIC4_ENST00000473709.1_3'UTR			Q96FT7	ACCN4_HUMAN	acid-sensing (proton-gated) ion channel family member 4	461						integral to plasma membrane	sodium channel activity|sodium ion transmembrane transporter activity										TGCCACTGCCGGATGGTGCAC	0.667000													9	13					0	0	1	0	0
ARHGAP18	93663	broad.mit.edu	37	6	129959694	129959694	+	Missense_Mutation	SNP	T	T	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr6:129959694T>G	ENST00000368149.2	-	3	485	c.397A>C	c.(397-399)Agc>Cgc	p.S133R		NM_033515.2	NP_277050.2	Q8N392	RHG18_HUMAN	Rho GTPase activating protein 18	133					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			NS(2)|endometrium(1)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(3)	18				OV - Ovarian serous cystadenocarcinoma(136;0.0621)|GBM - Glioblastoma multiforme(226;0.0638)|all cancers(137;0.074)		AACACAATGCTTTCCTGTGGA	0.463000													24	40					0	0	1	0	0
CDKN2AIP	55602	broad.mit.edu	37	4	184367240	184367240	+	Splice_Site	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr4:184367240G>C	ENST00000504169.1	+	3	610		c.e3-1		CDKN2AIP_ENST00000506835.1_Splice_Site|CDKN2AIP_ENST00000302350.4_Splice_Site	NM_017632.2	NP_060102.1	Q9NXV6	CARF_HUMAN	CDKN2A interacting protein						negative regulation of cell growth|positive regulation of signal transduction|regulation of protein stability	granular component|nucleoplasm	double-stranded RNA binding|p53 binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(1)	6		all_lung(41;6.9e-12)|Lung NSC(41;1.28e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;1.15e-26)|Epithelial(43;2.98e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|GBM - Glioblastoma multiforme(59;4.22e-06)|Colorectal(24;5.87e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		CTTCTTTTTAGAAGGGGTAGA	0.373000													17	33					0	0	1	0	0
MON2	23041	broad.mit.edu	37	12	62959089	62959089	+	Missense_Mutation	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:62959089G>C	ENST00000393630.3	+	28	4499	c.4108G>C	c.(4108-4110)Gaa>Caa	p.E1370Q	MON2_ENST00000546600.1_Missense_Mutation_p.E1369Q|MON2_ENST00000393632.2_Missense_Mutation_p.E1369Q|MON2_ENST00000393629.2_Missense_Mutation_p.E1369Q|MON2_ENST00000280379.6_Missense_Mutation_p.E1370Q|MON2_ENST00000552738.1_Missense_Mutation_p.E1346Q	NM_001278470.1|NM_001278472.1	NP_001265399.1|NP_001265401.1	Q7Z3U7	MON2_HUMAN	MON2 homolog (S. cerevisiae)	1370					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(15)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	57			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		GGCATTTGTAGAATTTTCCTG	0.328000													26	74					0	0	1	0	0
ACP2	53	broad.mit.edu	37	11	47261668	47261668	+	Silent	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr11:47261668C>T	ENST00000256997.3	-	11	1387	c.1271G>A	c.(1270-1272)tGa>tAa	p.*424*	ACP2_ENST00000533929.1_Silent_p.*396*|ACP2_ENST00000537863.1_Silent_p.*237*|ACP2_ENST00000527256.1_Silent_p.*392*|ACP2_ENST00000529444.1_Silent_p.*361*|ACP2_ENST00000525230.1_5'UTR	NM_001610.2	NP_001601.1	P11117	PPAL_HUMAN	acid phosphatase 2, lysosomal	0						integral to membrane|lysosomal lumen|lysosomal membrane	acid phosphatase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)	10						GAGTGGTTGTCAGGCGTGGTC	0.652000													15	22					0	0	1	0	0
FAM208B	54906	broad.mit.edu	37	10	5784258	5784258	+	Silent	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr10:5784258T>C	ENST00000328090.5	+	14	3151	c.2526T>C	c.(2524-2526)ctT>ctC	p.L842L	RP11-336A10.2_ENST00000411512.2_RNA	NM_017782.4	NP_060252	Q5VWN6	CJ018_HUMAN	family with sequence similarity 208, member B	842																	AGGAGTCCCTTGGTTTGGAAA	0.443000													26	134					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108698499	108698499	+	Silent	SNP	C	C	G	rs75923723	by1000genomes	TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:108698499C>G	ENST00000232603.5	-	24	2422	c.2340G>C	c.(2338-2340)ccG>ccC	p.P780P	MORC1_ENST00000483760.1_Silent_p.P759P	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	780					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						CATCTTCCATCGGCACATTGA	0.388000													30	97					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46859774	46859774	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr22:46859774A>G	ENST00000262738.3	-	2	4012	c.4013T>C	c.(4012-4014)tTc>tCc	p.F1338S	CELSR1_ENST00000395964.1_Missense_Mutation_p.F1338S	NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	1338	EGF-like 1; calcium-binding.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GATGGGCCGGAAGAGCACGGT	0.657000													5	10					0	0	1	0	0
LOC220729	220729	broad.mit.edu	37	3	197348739	197348739	+	RNA	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:197348739G>C	ENST00000418868.1	-	0	520					NR_003266.2																						TAATTTTCTAGCTGTGAAAGA	0.398000													5	114					0	0	1	0	0
FMN1	342184	broad.mit.edu	37	15	33261603	33261603	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr15:33261603C>G	ENST00000334528.9	-	4	1629	c.1630G>C	c.(1630-1632)Gaa>Caa	p.E544Q	FMN1_ENST00000559047.1_Missense_Mutation_p.E767Q|FMN1_ENST00000561249.1_Missense_Mutation_p.E669Q	NM_001103184.2	NP_001096654.1	Q68DA7	FMN1_HUMAN	formin 1	767	Mediates interaction with alpha-catenin (By similarity).|Microtubule-binding (By similarity).				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	29		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		TTCAGATTTTCAATGGTTTCT	0.463000													45	128					0	0	1	0	0
ALDH18A1	5832	broad.mit.edu	37	10	97380921	97380921	+	Missense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr10:97380921G>A	ENST00000371224.2	-	12	1471	c.1334C>T	c.(1333-1335)gCc>gTc	p.A445V	ALDH18A1_ENST00000371221.3_Missense_Mutation_p.A443V	NM_002860.3	NP_002851.2	P54886	P5CS_HUMAN	aldehyde dehydrogenase 18 family, member A1	445	Gamma-glutamyl phosphate reductase.				proline biosynthetic process	mitochondrial inner membrane	ATP binding|glutamate 5-kinase activity|glutamate-5-semialdehyde dehydrogenase activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(9)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Colorectal(252;0.0402)		Epithelial(162;9.1e-07)|all cancers(201;2.55e-05)	L-Glutamic Acid(DB00142)	CTGGGAGGAGGCTGCGATCTG	0.542000													10	19					0	0	1	0	0
ZNF181	339318	broad.mit.edu	37	19	35232642	35232642	+	Missense_Mutation	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:35232642G>C	ENST00000392232.3	+	6	1656	c.1488G>C	c.(1486-1488)ttG>ttC	p.L496F	ZNF181_ENST00000459757.2_Missense_Mutation_p.L451F|ZNF181_ENST00000492450.1_Missense_Mutation_p.L452F			Q2M3W8	ZN181_HUMAN	zinc finger protein 181	452					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(6)|kidney(2)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|skin(1)	22	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			ATATGCATTTGAGAAATCACA	0.383000													21	40					0	0	1	0	0
ACRBP	84519	broad.mit.edu	37	12	6753454	6753454	+	Missense_Mutation	SNP	G	G	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:6753454G>T	ENST00000229243.2	-	5	886	c.793C>A	c.(793-795)Cct>Act	p.P265T	ACRBP_ENST00000414226.2_Missense_Mutation_p.P232T|ACRBP_ENST00000536350.1_Missense_Mutation_p.P265T	NM_032489.2	NP_115878.2	Q8NEB7	ACRBP_HUMAN	acrosin binding protein	265						acrosomal vesicle|extracellular region				NS(1)|breast(1)|central_nervous_system(1)|large_intestine(8)|lung(5)|ovary(1)	17						AAAGAGGAAGGGTTAGAAGAT	0.498000													29	33					3.73808e-20	3.9879e-20	1	1	0
MAP1B	4131	broad.mit.edu	37	5	71492598	71492598	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr5:71492598C>G	ENST00000296755.7	+	5	3714	c.3416C>G	c.(3415-3417)cCt>cGt	p.P1139R		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1139						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		ATGTCTACCCCTCGAGACGTG	0.473000													5	18					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168104896	168104896	+	Missense_Mutation	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:168104896G>C	ENST00000409195.1	+	9	7083	c.6994G>C	c.(6994-6996)Gag>Cag	p.E2332Q	XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.E2332Q|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.E2110Q|XIRP2_ENST00000409756.2_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2157					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						ACTGTCCACAGAGAAGATAAA	0.423000													30	70					0	0	1	0	0
WDR65	149465	broad.mit.edu	37	1	43649388	43649388	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:43649388C>G	ENST00000372492.4	+	4	925	c.601C>G	c.(601-603)Cta>Gta	p.L201V	WDR65_ENST00000528956.1_Missense_Mutation_p.L201V	NM_001195831.2	NP_001182760.2	Q96MR6	WDR65_HUMAN	WD repeat domain 65	201										NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CCAAAACTATCTAGCTCACAC	0.498000													46	84					0	0	1	0	0
WDR38	401551	broad.mit.edu	37	9	127618540	127618540	+	Missense_Mutation	SNP	T	T	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr9:127618540T>A	ENST00000373574.1	+	5	483	c.427T>A	c.(427-429)Tta>Ata	p.L143I		NM_001045476.1|NM_001276374.1	NP_001038941.1|NP_001263303.1	Q5JTN6	WDR38_HUMAN	WD repeat domain 38	143										breast(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	8						GCTGCGCCTCTTAGTTGGGCA	0.647000											OREG0019485	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	58					0	0	1	0	0
TPD52L2	7165	broad.mit.edu	37	20	62505086	62505086	+	Silent	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr20:62505086C>G	ENST00000217121.5	+	3	303	c.231C>G	c.(229-231)ctC>ctG	p.L77L	TPD52L2_ENST00000358548.4_Silent_p.L77L|TPD52L2_ENST00000352482.4_Silent_p.L77L|TPD52L2_ENST00000369927.4_Silent_p.L54L|TPD52L2_ENST00000348257.5_Silent_p.L77L|TPD52L2_ENST00000351424.4_Silent_p.L77L|TPD52L2_ENST00000346249.4_Silent_p.L77L	NM_199360.2	NP_955392.1	O43399	TPD54_HUMAN	tumor protein D52-like 2	77					regulation of cell proliferation	perinuclear region of cytoplasm	protein binding|protein homodimerization activity			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	8	all_cancers(38;1.3e-12)|all_epithelial(29;2.23e-14)|Lung NSC(23;5.92e-10)|all_lung(23;2.08e-09)					GTGGAGAGCTCAAGAGGAGGC	0.592000													6	9					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72992248	72992248	+	Missense_Mutation	SNP	A	A	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr16:72992248A>T	ENST00000268489.5	-	2	2469	c.1797T>A	c.(1795-1797)aaT>aaA	p.N599K	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	599					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				GTGCTGTGGCATTGTCTTTAT	0.577000													11	24					0	0	1	0	0
PLA2G6	8398	broad.mit.edu	37	22	38509521	38509521	+	Silent	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr22:38509521C>T	ENST00000332509.3	-	15	2358	c.2175G>A	c.(2173-2175)aaG>aaA	p.K725K	PLA2G6_ENST00000402064.1_Silent_p.K671K|PLA2G6_ENST00000335539.3_Silent_p.K671K	NM_003560.2	NP_003551.2	O60733	PA2G6_HUMAN	phospholipase A2, group VI (cytosolic, calcium-independent)	725					cardiolipin biosynthetic process|cell death|lipid catabolic process	centrosome|membrane				breast(2)|endometrium(6)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	24	Melanoma(58;0.045)				Quinacrine(DB01103)	TGCCCAGTTCCTTGGCCCCAA	0.627000													40	14					0	0	1	0	0
TXNDC16	57544	broad.mit.edu	37	14	53003467	53003467	+	Missense_Mutation	SNP	T	T	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr14:53003467T>G	ENST00000281741.4	-	6	733	c.362A>C	c.(361-363)gAt>gCt	p.D121A	TXNDC16_ENST00000554399.1_Intron	NM_001160047.1|NM_020784.2	NP_001153519.1|NP_065835.2	Q9P2K2	TXD16_HUMAN	thioredoxin domain containing 16	121					cell redox homeostasis	extracellular region				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|prostate(3)|skin(1)	21	Breast(41;0.0716)					GGCATTCACATCAAACAAGGT	0.318000													10	23					0	0	1	0	0
QPCTL	54814	broad.mit.edu	37	19	46205058	46205058	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:46205058A>G	ENST00000012049.5	+	6	1110	c.889A>G	c.(889-891)Aag>Gag	p.K297E	QPCTL_ENST00000366382.4_Missense_Mutation_p.K203E	NM_017659.3	NP_060129.2	Q9NXS2	QPCTL_HUMAN	glutaminyl-peptide cyclotransferase-like	297					peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	Golgi membrane|integral to membrane	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|protein binding|zinc ion binding			breast(1)|cervix(2)|endometrium(1)|lung(5)|skin(1)|stomach(1)	11		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0059)|GBM - Glioblastoma multiforme(486;0.0882)|Epithelial(262;0.208)		ACTTCCAGAGAAGCGTCTGCA	0.557000													21	74					0	0	1	0	0
KIAA0319	9856	broad.mit.edu	37	6	24596147	24596147	+	Missense_Mutation	SNP	T	T	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr6:24596147T>G	ENST00000535378.1	-	4	1370	c.728A>C	c.(727-729)aAg>aCg	p.K243T	KIAA0319_ENST00000430948.2_Missense_Mutation_p.K207T|KIAA0319_ENST00000378214.3_Missense_Mutation_p.K252T|KIAA0319_ENST00000543707.1_Missense_Mutation_p.K252T|KIAA0319_ENST00000537886.1_Missense_Mutation_p.K252T	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	252					negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						CTGAGAAGCCTTTTCTTTCTC	0.542000													24	107					0	0	1	0	0
C4orf29	80167	broad.mit.edu	37	4	128949867	128949867	+	Missense_Mutation	SNP	A	A	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr4:128949867A>T	ENST00000388795.5	+	11	1196	c.793A>T	c.(793-795)Aac>Tac	p.N265Y	C4orf29_ENST00000398965.1_Missense_Mutation_p.N313Y|C4orf29_ENST00000444616.1_Missense_Mutation_p.N313Y			Q0P651	CD029_HUMAN	chromosome 4 open reading frame 29	313						extracellular region				breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	8						ACTTTCAACCAACAAAAGTGG	0.383000													44	11					0	0	1	0	0
LRRCC1	85444	broad.mit.edu	37	8	86027662	86027662	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr8:86027662T>C	ENST00000414626.2	+	5	1602	c.713T>C	c.(712-714)tTg>tCg	p.L238S	LRRCC1_ENST00000360375.3_Missense_Mutation_p.L258S			Q9C099	LRCC1_HUMAN	leucine rich repeat and coiled-coil centrosomal protein 1	258					cell division|mitosis	centriole|nucleus				breast(3)|central_nervous_system(1)|endometrium(4)|kidney(9)|large_intestine(7)|lung(16)|skin(1)|upper_aerodigestive_tract(2)	43						TTAGTTCCCTTGGAACAGTTT	0.358000													29	52					0	0	1	0	0
SPTLC3	55304	broad.mit.edu	37	20	13053012	13053012	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr20:13053012T>C	ENST00000399002.2	+	3	686	c.412T>C	c.(412-414)Ttt>Ctt	p.F138L	SPTLC3_ENST00000378194.4_Missense_Mutation_p.F138L	NM_018327.2	NP_060797.2	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base subunit 3	138					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(1)|endometrium(1)|large_intestine(7)|lung(14)|skin(1)|urinary_tract(1)	25					Pyridoxal Phosphate(DB00114)	AGGGCCTCTGTTTGATTTGAT	0.438000													34	170					0	0	1	0	0
ESF1	51575	broad.mit.edu	37	20	13740438	13740438	+	Missense_Mutation	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr20:13740438C>T	ENST00000202816.1	-	9	1836	c.1729G>A	c.(1729-1731)Gaa>Aaa	p.E577K		NM_001276380.1|NM_016649.3	NP_001263309.1|NP_057733.2	Q9H501	ESF1_HUMAN	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)	577	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|skin(1)|stomach(1)	31						GCAATTTGTTCTTCATCATCC	0.328000													12	26					0	0	1	0	0
CENPJ	55835	broad.mit.edu	37	13	25458175	25458175	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr13:25458175C>G	ENST00000381884.4	-	16	3935	c.3750G>C	c.(3748-3750)caG>caC	p.Q1250H	CENPJ_ENST00000545981.1_3'UTR	NM_018451.4	NP_060921.3	Q9HC77	CENPJ_HUMAN	centromere protein J	1250					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding	p.Q1250H(1)		endometrium(5)|kidney(4)|large_intestine(14)|lung(13)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		TTTTAACAGTCTGGTCAGGAA	0.333000													19	28					0	0	1	0	0
ONECUT2	9480	broad.mit.edu	37	18	55104053	55104053	+	Missense_Mutation	SNP	T	T	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr18:55104053T>A	ENST00000491143.2	+	1	1137	c.1105T>A	c.(1105-1107)Tcc>Acc	p.S369T		NM_004852.2	NP_004843.2	O95948	ONEC2_HUMAN	one cut homeobox 2	369					organ morphogenesis	nucleus	sequence-specific DNA binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|lung(4)|ovary(2)|skin(1)	15		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		GGGGACTCTCTCCGACCTGCT	0.602000													6	17					0	0	1	0	0
SLC22A14	9389	broad.mit.edu	37	3	38357068	38357068	+	Silent	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:38357068C>G	ENST00000273173.4	+	8	1489	c.1398C>G	c.(1396-1398)ctC>ctG	p.L466L	SLC22A14_ENST00000448498.1_Silent_p.L466L	NM_004803.3	NP_004794.2	Q9Y267	S22AE_HUMAN	solute carrier family 22, member 14	466			L -> P (in dbSNP:rs34256819).			integral to plasma membrane	organic cation transmembrane transporter activity			central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(5)|prostate(2)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0554)|Kidney(284;0.0696)		GCCTCAGACTCAAGTGGCCAC	0.592000													17	44					0	0	1	0	0
ZZZ3	26009	broad.mit.edu	37	1	78098107	78098107	+	Silent	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:78098107T>C	ENST00000370801.3	-	5	1408	c.933A>G	c.(931-933)ttA>ttG	p.L311L	ZZZ3_ENST00000370798.1_Intron|ZZZ3_ENST00000476275.1_5'UTR	NM_015534.4	NP_056349.1	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	311					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(1)|stomach(1)|urinary_tract(2)	39						CAGAATCCCTTAAAGATGACT	0.453000													16	68					0	0	1	0	0
MGA	23269	broad.mit.edu	37	15	42021447	42021447	+	Missense_Mutation	SNP	A	A	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr15:42021447A>C	ENST00000219905.7	+	11	3924	c.3743A>C	c.(3742-3744)aAa>aCa	p.K1248T	MGA_ENST00000570161.1_Missense_Mutation_p.K1248T|MGA_ENST00000389936.4_Missense_Mutation_p.K1248T|MGA_ENST00000545763.1_Missense_Mutation_p.K1248T|MGA_ENST00000566586.1_Missense_Mutation_p.K1248T	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	1248						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		GAGCGAAAAAAAGAGGACCAG	0.418000													7	19					0	0	1	0	0
MAP4K1	11184	broad.mit.edu	37	19	39098768	39098768	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:39098768C>G	ENST00000591517.1	-	14	1077	c.1049G>C	c.(1048-1050)aGa>aCa	p.R350T	MAP4K1_ENST00000423454.2_Missense_Mutation_p.R12T|MAP4K1_ENST00000586296.1_Intron|MAP4K1_ENST00000589002.1_5'UTR|MAP4K1_ENST00000396857.2_Missense_Mutation_p.R350T|MAP4K1_ENST00000589130.1_Missense_Mutation_p.R346T	NM_007181.4	NP_009112.1	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase kinase 1	350					activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(24)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	44	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GGCTGGGGGTCTGGTCTCCAT	0.632000													8	32					0	0	1	0	0
CACNA2D1	781	broad.mit.edu	37	7	81593586	81593586	+	Nonsense_Mutation	SNP	A	A	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr7:81593586A>C	ENST00000356860.3	-	33	3002	c.2664T>G	c.(2662-2664)taT>taG	p.Y888*	CACNA2D1_ENST00000535308.1_Nonsense_Mutation_p.Y100*|CACNA2D1_ENST00000356253.5_Nonsense_Mutation_p.Y900*	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1	900						voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	ATACTGACTGATAATCATAAG	0.413000													29	42					0	0	1	0	0
FUNDC2P2	388965	broad.mit.edu	37	2	84518085	84518085	+	RNA	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:84518085A>G	ENST00000331369.5	+	0	279																											GTGGCAACCCACCTGTTCATT	0.507000													26	70					0	0	1	0	0
DNM1P46	196968	broad.mit.edu	37	15	100340273	100340273	+	RNA	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr15:100340273T>C	ENST00000341853.1	-	0	653					NR_003260.1																						CGCGCCGCTGTGCCTGCTCTG	0.637000													7	16					0	0	1	0	0
VEGFC	7424	broad.mit.edu	37	4	177608622	177608622	+	Missense_Mutation	SNP	T	T	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr4:177608622T>G	ENST00000280193.2	-	6	1279	c.864A>C	c.(862-864)gaA>gaC	p.E288D	RP11-313E19.2_ENST00000504017.1_RNA|RP11-313E19.2_ENST00000509194.1_RNA	NM_005429.2	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	288	4 X 16 AA repeats of C-X(10)-C-X-C- X(1,3)-C.				angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			biliary_tract(1)|cervix(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(2)|skin(2)	41		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		GACAGGTCTCTTCATCCAGCT	0.478000													8	29					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64465676	64465676	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr14:64465676A>G	ENST00000358025.3	+	27	3628	c.3398A>G	c.(3397-3399)aAc>aGc	p.N1133S	SYNE2_ENST00000357395.3_5'UTR|SYNE2_ENST00000344113.4_Missense_Mutation_p.N1133S|SYNE2_ENST00000554584.1_Missense_Mutation_p.N1133S	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	1133					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CTGCAAAACAACAAATTCAGG	0.353000													25	61					0	0	1	0	0
ZNF106	64397	broad.mit.edu	37	15	42742330	42742330	+	Missense_Mutation	SNP	T	T	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr15:42742330T>G	ENST00000263805.4	-	2	2397	c.2071A>C	c.(2071-2073)Aca>Cca	p.T691P	ZNF106_ENST00000565380.1_Intron|ZNF106_ENST00000565611.1_Intron	NM_001284306.1|NM_001284307.1|NM_022473.1	NP_001271235.1|NP_001271236.1|NP_071918.1			zinc finger protein 106																		AAGCCTTCTGTTTCATAAGAT	0.458000													6	152					0	0	1	0	0
RIMBP2	23504	broad.mit.edu	37	12	130898785	130898785	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:130898785T>C	ENST00000261655.4	-	14	2700	c.2537A>G	c.(2536-2538)gAa>gGa	p.E846G		NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	846						cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		CGGGAGCTCTTCGGCACCAGG	0.562000													11	29					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45645667	45645667	+	Missense_Mutation	SNP	G	G	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr5:45645667G>T	ENST00000303230.4	-	2	526	c.469C>A	c.(469-471)Cta>Ata	p.L157I		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	157						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						ATGATGACTAGATTTCCAACC	0.333000													12	88					6.40141e-05	6.49178e-05	1	1	0
PSG2	5670	broad.mit.edu	37	19	43585314	43585314	+	Missense_Mutation	SNP	T	T	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:43585314T>G	ENST00000406487.1	-	2	247	c.149A>C	c.(148-150)gAt>gCt	p.D50A		NM_031246.3	NP_112536.2	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	50	Ig-like V-type.				cell migration|female pregnancy	extracellular region		p.D50V(2)		central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(24)|ovary(1)|pancreas(2)|prostate(6)|stomach(2)|urinary_tract(2)	49		Prostate(69;0.00682)				TAGAAGAACATCCTTCCCCTC	0.468000													74	274					0	0	1	0	0
NDC1	55706	broad.mit.edu	37	1	54262441	54262441	+	Missense_Mutation	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:54262441G>C	ENST00000371429.3	-	13	2103	c.1505C>G	c.(1504-1506)tCt>tGt	p.S502C	NDC1_ENST00000537333.1_Missense_Mutation_p.S167C|NDC1_ENST00000234725.8_Missense_Mutation_p.S387C|NDC1_ENST00000540001.1_Missense_Mutation_p.S502C	NM_001168551.1|NM_018087.4	NP_001162023.1|NP_060557.3			NDC1 transmembrane nucleoporin																		AATAGAGGTAGATGGAGAAGG	0.368000													25	50					0	0	1	0	0
ZNF665	79788	broad.mit.edu	37	19	53678776	53678776	+	Missense_Mutation	SNP	A	A	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:53678776A>T	ENST00000396424.3	-	3	153	c.64T>A	c.(64-66)Tgg>Agg	p.W22R	ZNF665_ENST00000600412.1_Intron	NM_024733.3	NP_079009.3	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	35				GBM - Glioblastoma multiforme(134;0.0196)		AGGCATGTCCACTCCTCCTGA	0.433000													37	156					0	0	1	0	0
ULK4	54986	broad.mit.edu	37	3	41977387	41977387	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:41977387T>C	ENST00000301831.4	-	4	746	c.284A>G	c.(283-285)gAa>gGa	p.E95G	ULK4_ENST00000420927.1_Missense_Mutation_p.E95G	NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4	95	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		CACAACATCTTCTGGGAGGTT	0.393000													18	32					0	0	1	0	0
IFRD2	7866	broad.mit.edu	37	3	50327675	50327675	+	Missense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:50327675G>A	ENST00000436390.1	-	7	811	c.314C>T	c.(313-315)tCc>tTc	p.S105F	IFRD2_ENST00000417626.2_Missense_Mutation_p.S105F|IFRD2_ENST00000336089.4_Missense_Mutation_p.S271F|IFRD2_ENST00000429673.2_Missense_Mutation_p.S169F|IFRD2_ENST00000484043.1_5'UTR			Q12894	IFRD2_HUMAN	interferon-related developmental regulator 2	169							binding			breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)	14				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GAGTAGGCGGGACGCTAGGGC	0.647000													5	12					0	0	1	0	0
HCAR2	338442	broad.mit.edu	37	12	123187822	123187822	+	Silent	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:123187822C>T	ENST00000328880.5	-	1	68	c.9G>A	c.(7-9)cgG>cgA	p.R3R	HCAR1_ENST00000356987.2_Intron|RP11-324E6.6_ENST00000543611.1_lincRNA	NM_177551.3	NP_808219.1	Q8TDS4	HCAR2_HUMAN	hydroxycarboxylic acid receptor 2	3					negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	15					Mepenzolate(DB04843)|Niacin(DB00627)	GCAGATGGTGCCGATTCATGA	0.547000													4	135					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82815664	82815664	+	Missense_Mutation	SNP	C	C	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr5:82815664C>A	ENST00000265077.3	+	7	2104	c.1539C>A	c.(1537-1539)ttC>ttA	p.F513L	VCAN_ENST00000502527.2_Intron|VCAN_ENST00000342785.4_Missense_Mutation_p.F513L|VCAN_ENST00000343200.5_Intron|VCAN_ENST00000512590.2_Missense_Mutation_p.F465L	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	513	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CCAAGGAATTCCCTGTAACTG	0.378000													49	50					1.19451e-25	1.29031e-25	1	1	0
DNAJC16	23341	broad.mit.edu	37	1	15862989	15862989	+	Missense_Mutation	SNP	A	A	C	rs28606019		TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:15862989A>C	ENST00000375847.3	+	4	418	c.254A>C	c.(253-255)aAg>aCg	p.K85T	DNAJC16_ENST00000375849.1_Missense_Mutation_p.K85T|DNAJC16_ENST00000375838.1_Missense_Mutation_p.K85T	NM_015291.2	NP_056106.1	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	85	J.				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(7)|urinary_tract(1)	18		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		AATGAAGAAAAGAGATCAAAT	0.378000													9	14					0	0	1	0	0
NARG2	79664	broad.mit.edu	37	15	60715834	60715834	+	Nonstop_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr15:60715834C>G	ENST00000261520.4	-	16	3182	c.2948G>C	c.(2947-2949)tGa>tCa	p.*983S	NARG2_ENST00000439632.1_Nonstop_Mutation_p.*846S	NM_024611.4	NP_078887.2	Q659A1	NARG2_HUMAN	NMDA receptor regulated 2	0						nucleus				breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	32						GTACAGTCCTCAAGTTATTTT	0.363000													9	28					0	0	1	0	0
ZNF442	79973	broad.mit.edu	37	19	12461868	12461868	+	Silent	SNP	T	T	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:12461868T>A	ENST00000242804.4	-	6	1113	c.531A>T	c.(529-531)ggA>ggT	p.G177G	ZNF442_ENST00000438182.1_Silent_p.G108G	NM_030824.2	NP_110451.1	Q9H7R0	ZN442_HUMAN	zinc finger protein 442	177					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(8)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	31						AGCGTTTCTTTCCAGTGTGAG	0.418000													35	52					0	0	1	0	0
EPHA1	2041	broad.mit.edu	37	7	143091978	143091978	+	Missense_Mutation	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr7:143091978G>C	ENST00000275815.3	-	14	2361	c.2275C>G	c.(2275-2277)Caa>Gaa	p.Q759E		NM_005232.4	NP_005223.4	P21709	EPHA1_HUMAN	EPH receptor A1	759	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(21)|ovary(4)|skin(1)|stomach(1)|urinary_tract(3)	51	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				CACAGGTTTTGATTCACCAAG	0.522000													13	39					0	0	1	0	0
CD22	933	broad.mit.edu	37	19	35832501	35832501	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:35832501A>G	ENST00000085219.5	+	8	1829	c.1763A>G	c.(1762-1764)gAa>gGa	p.E588G	CD22_ENST00000536635.2_Missense_Mutation_p.E500G|CD22_ENST00000341773.6_Missense_Mutation_p.E411G|CD22_ENST00000594250.1_Missense_Mutation_p.E411G|CD22_ENST00000419549.2_Missense_Mutation_p.E416G|CD22_ENST00000544992.2_Missense_Mutation_p.E588G|CD22_ENST00000270311.6_Missense_Mutation_p.E468G	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	588					cell adhesion		protein binding|sugar binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	TGGACACTTGAAGTGCTGTGT	0.597000													16	75					0	0	1	0	0
NCK2	8440	broad.mit.edu	37	2	106498105	106498105	+	Missense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:106498105G>A	ENST00000233154.4	+	4	990	c.548G>A	c.(547-549)cGc>cAc	p.R183H	NCK2_ENST00000451463.2_Intron|NCK2_ENST00000522586.1_Intron|NCK2_ENST00000393349.2_Missense_Mutation_p.R183H	NM_003581.4	NP_003572.2	O43639	NCK2_HUMAN	NCK adaptor protein 2	183					axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			endometrium(1)|lung(3)|ovary(1)	5						CTGAGCCTGCGCAAGGGCGCC	0.652000													14	24					0	0	1	0	0
TCERG1	10915	broad.mit.edu	37	5	145834827	145834827	+	Missense_Mutation	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr5:145834827G>C	ENST00000296702.5	+	2	306	c.268G>C	c.(268-270)Ggc>Cgc	p.G90R	TCERG1_ENST00000394421.2_Missense_Mutation_p.G90R	NM_006706.3	NP_006697.2	O14776	TCRG1_HUMAN	transcription elongation regulator 1	90	Pro-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(18)|lung(9)|ovary(2)|prostate(3)|skin(1)	46		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCCACCTATGGGCCCTCCACA	0.488000													29	31					0	0	1	0	0
ITGA11	22801	broad.mit.edu	37	15	68657094	68657094	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr15:68657094A>G	ENST00000423218.2	-	4	403	c.308T>C	c.(307-309)aTg>aCg	p.M103T	ITGA11_ENST00000315757.7_Missense_Mutation_p.M103T|ITGA11_ENST00000562826.1_5'UTR			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	103					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	GCCGAGGCGCATGTTGTCTTT	0.642000													7	21					0	0	1	0	0
CNOT1	23019	broad.mit.edu	37	16	58614553	58614553	+	Nonsense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr16:58614553G>A	ENST00000317147.5	-	12	1659	c.1327C>T	c.(1327-1329)Cga>Tga	p.R443*	CNOT1_ENST00000569240.1_Nonsense_Mutation_p.R443*|CNOT1_ENST00000441024.2_Nonsense_Mutation_p.R443*	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	443					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		GCAATTTCTCGATTGTCATCC	0.343000													10	27					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200959321	200959321	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:200959321A>G	ENST00000332129.2	-	20	3291	c.2975T>C	c.(2974-2976)aTc>aCc	p.I992T	KIF21B_ENST00000461742.2_Missense_Mutation_p.I992T|KIF21B_ENST00000422435.2_Missense_Mutation_p.I992T|KIF21B_ENST00000360529.5_Missense_Mutation_p.I992T	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	992					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						GCCGTCATTGATGTAGTCAAT	0.647000													4	44					0	0	1	0	0
MCM10	55388	broad.mit.edu	37	10	13228174	13228174	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr10:13228174C>G	ENST00000378694.1	+	8	1184	c.1109C>G	c.(1108-1110)tCt>tGt	p.S370C	MCM10_ENST00000378714.3_Missense_Mutation_p.S370C|MCM10_ENST00000484800.2_Missense_Mutation_p.S371C			Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	371					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			central_nervous_system(1)|large_intestine(4)|ovary(2)|skin(1)|stomach(1)	9						GTGTGTTTATCTATCGATCAT	0.438000													51	181					0	0	1	0	0
SLFN11	91607	broad.mit.edu	37	17	33680027	33680027	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr17:33680027T>C	ENST00000394566.1	-	7	2326	c.2054A>G	c.(2053-2055)aAa>aGa	p.K685R	SLFN11_ENST00000308377.4_Missense_Mutation_p.K685R	NM_001104587.1|NM_001104588.1|NM_001104589.1|NM_001104590.1	NP_001098057.1|NP_001098058.1|NP_001098059.1|NP_001098060.1	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	685						nucleus	ATP binding			autonomic_ganglia(1)|breast(1)|kidney(3)|large_intestine(14)|lung(17)|ovary(1)|prostate(4)|skin(2)|stomach(5)|upper_aerodigestive_tract(2)	50		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGTGATGCTTTTTGCCTTCCC	0.468000													39	74					0	0	1	0	0
FAM21A	387680	broad.mit.edu	37	10	51829387	51829387	+	Silent	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr10:51829387T>C	ENST00000351071.6	+	3	325	c.207T>C	c.(205-207)atT>atC	p.I69I	FAM21A_ENST00000282633.5_Silent_p.I69I|FAM21A_ENST00000314664.7_Silent_p.I69I|FAM21A_ENST00000492914.1_3'UTR			Q641Q2	FA21A_HUMAN	family with sequence similarity 21, member A	69					retrograde transport, endosome to Golgi	early endosome membrane|WASH complex		p.I69I(3)		breast(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	15						ACGGACTAATTCGGGAAACCA	0.368000													4	266					0	0	1	0	0
WDR11	55717	broad.mit.edu	37	10	122612070	122612070	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr10:122612070T>C	ENST00000263461.6	+	2	367	c.121T>C	c.(121-123)Tca>Cca	p.S41P		NM_018117.11	NP_060587.8	Q9BZH6	WDR11_HUMAN	WD repeat domain 11	41						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(9)|prostate(2)|skin(2)|stomach(5)	38						TGGATGTCATTCACTTGTGGT	0.383000													21	31					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100345782	100345782	+	RNA	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr7:100345782G>A	ENST00000542585.1	+	0	1194				ZAN_ENST00000427578.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000546213.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GGCGTTTTTGGAAAGACCCCA	0.587000													11	16					0	0	1	0	0
STAG1	10274	broad.mit.edu	37	3	136139966	136139966	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:136139966A>G	ENST00000383202.2	-	20	2333	c.2077T>C	c.(2077-2079)Tct>Cct	p.S693P	STAG1_ENST00000536929.1_Missense_Mutation_p.S277P|STAG1_ENST00000434713.2_Missense_Mutation_p.S467P|STAG1_ENST00000236698.5_Missense_Mutation_p.S693P	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	693					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						TTTAATGTAGAAAGAACATTG	0.348000													25	99					0	0	1	0	0
SLC1A5	6510	broad.mit.edu	37	19	47285670	47285670	+	Missense_Mutation	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:47285670G>C	ENST00000542575.2	-	4	1422	c.794C>G	c.(793-795)gCc>gGc	p.A265G	SLC1A5_ENST00000412532.2_Missense_Mutation_p.A37G|SLC1A5_ENST00000594991.1_Missense_Mutation_p.A89G|SLC1A5_ENST00000434726.2_Missense_Mutation_p.A63G	NM_005628.2	NP_005619.1	Q15758	AAAT_HUMAN	solute carrier family 1 (neutral amino acid transporter), member 5	265					cellular nitrogen compound metabolic process	integral to plasma membrane|melanosome|membrane fraction	neutral amino acid transmembrane transporter activity|protein binding|receptor activity|sodium:dicarboxylate symporter activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(2)|stomach(1)	13		all_epithelial(76;0.00314)|Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000338)|all cancers(93;0.000882)|Epithelial(262;0.0211)|GBM - Glioblastoma multiforme(486;0.0341)	L-Asparagine(DB00174)|L-Glutamine(DB00130)	AACCATGGTGGCCTCATTGAA	0.612000													9	51					0	0	1	0	0
IRF3	3661	broad.mit.edu	37	19	50166673	50166673	+	Missense_Mutation	SNP	T	T	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:50166673T>G	ENST00000597198.1	-	3	645	c.264A>C	c.(262-264)gaA>gaC	p.E88D	IRF3_ENST00000377139.3_Missense_Mutation_p.E88D|IRF3_ENST00000309877.7_Missense_Mutation_p.E88D|IRF3_ENST00000600911.1_Missense_Mutation_p.E88D|IRF3_ENST00000442265.2_Intron|IRF3_ENST00000600022.1_5'UTR|IRF3_ENST00000601291.1_Missense_Mutation_p.E88D|IRF3_ENST00000599223.1_Missense_Mutation_p.E88D|IRF3_ENST00000593922.1_5'UTR|IRF3_ENST00000596822.1_5'UTR|IRF3_ENST00000599144.1_Intron|IRF3_ENST00000596765.1_Intron|IRF3_ENST00000598808.1_5'UTR|IRF3_ENST00000377135.4_Missense_Mutation_p.E88D			Q14653	IRF3_HUMAN	interferon regulatory factor 3	88					interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|endosome membrane|nucleoplasm|plasma membrane	DNA binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|large_intestine(2)|lung(4)|ovary(2)|stomach(1)	10		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.02)		AACGCAACCCTTCTTTGCGGT	0.572000													5	43					0	0	1	0	0
ST3GAL5	8869	broad.mit.edu	37	2	86071658	86071658	+	Missense_Mutation	SNP	A	A	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:86071658A>T	ENST00000377332.3	-	6	977	c.869T>A	c.(868-870)tTc>tAc	p.F290Y	ST3GAL5_ENST00000393805.1_Missense_Mutation_p.F262Y|ST3GAL5_ENST00000393808.3_Missense_Mutation_p.F267Y	NM_003896.3	NP_003887.3	Q9UNP4	SIAT9_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	290					ganglioside biosynthetic process|protein glycosylation	integral to Golgi membrane|integral to plasma membrane	lactosylceramide alpha-2,3-sialyltransferase activity|neolactotetraosylceramide alpha-2,3-sialyltransferase activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	15						CTTCCAAAAGAAGAGTCGTAC	0.458000													12	50					0	0	1	0	0
SLCO4A1	28231	broad.mit.edu	37	20	61297783	61297783	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr20:61297783T>C	ENST00000217159.1	+	7	1533	c.1328T>C	c.(1327-1329)tTt>tCt	p.F443S	SLCO4A1_ENST00000370507.1_Missense_Mutation_p.F443S|RP11-93B14.5_ENST00000451648.1_RNA|SLCO4A1_ENST00000470412.1_3'UTR|RP11-93B14.5_ENST00000411824.1_RNA|RP11-93B14.5_ENST00000433126.1_RNA	NM_016354.3	NP_057438.3	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family, member 4A1	443					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(1)|lung(7)|ovary(3)|prostate(2)	21	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			GGCGGCTTCTTTGTGAACAAG	0.647000													26	88					0	0	1	0	0
NCKAP5L	57701	broad.mit.edu	37	12	50190039	50190039	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:50190039A>G	ENST00000335999.6	-	8	1805	c.1604T>C	c.(1603-1605)cTc>cCc	p.L535P		NM_001037806.3	NP_001032895.2	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	531	Pro-rich.									central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(8)|prostate(2)	18						CGGGGGTCTGAGCTGTGTGGA	0.637000													3	11					0	0	1	0	0
CPN2	1370	broad.mit.edu	37	3	194062010	194062010	+	Missense_Mutation	SNP	T	T	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:194062010T>A	ENST00000323830.3	-	2	1511	c.1422A>T	c.(1420-1422)gaA>gaT	p.E474D	CPN2_ENST00000429275.1_Missense_Mutation_p.E474D	NM_001080513.2	NP_001073982	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	474					protein stabilization	extracellular region	enzyme regulator activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(5)|prostate(1)	27	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		GGGCTGCCCTTTCCTGCACAG	0.667000													20	79					0	0	1	0	0
TBC1D1	23216	broad.mit.edu	37	4	38117392	38117392	+	Silent	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr4:38117392T>C	ENST00000261439.4	+	16	2974	c.2619T>C	c.(2617-2619)ctT>ctC	p.L873L	TBC1D1_ENST00000407365.1_3'UTR|TBC1D1_ENST00000508802.1_Silent_p.L967L	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	873	Rab-GAP TBC.					nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						AGCTATCGCTTTACAACATTT	0.428000													29	54					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65464349	65464349	+	Silent	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:65464349G>A	ENST00000330909.8	-	4	674	c.675C>T	c.(673-675)taC>taT	p.Y225Y	MAGI1_ENST00000470990.1_5'UTR|MAGI1_ENST00000483466.1_Silent_p.Y225Y|MAGI1_ENST00000402939.2_Silent_p.Y225Y|MAGI1_ENST00000497477.2_Silent_p.Y225Y	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	225	Guanylate kinase-like.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		GCATATCATTGTAGGACTTGG	0.512000													32	37					0	0	1	0	0
WNT2	7472	broad.mit.edu	37	7	116937822	116937822	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr7:116937822A>G	ENST00000265441.3	-	4	996	c.697T>C	c.(697-699)Tat>Cat	p.Y233H		NM_003391.2	NP_003382.1	P09544	WNT2_HUMAN	wingless-type MMTV integration site family member 2	233					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|ovary(3)|prostate(1)|skin(2)	31	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		CTCCAGAGATAATCGCCCGTT	0.532000													28	36					0	0	1	0	0
AURKC	6795	broad.mit.edu	37	19	57746385	57746385	+	Missense_Mutation	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:57746385G>C	ENST00000302804.7	+	6	904	c.718G>C	c.(718-720)Gag>Cag	p.E240Q	AURKC_ENST00000598785.1_Missense_Mutation_p.E206Q|AURKC_ENST00000415300.2_Missense_Mutation_p.E221Q|AURKC_ENST00000448930.1_Missense_Mutation_p.E206Q|AURKC_ENST00000599062.1_Missense_Mutation_p.E237Q	NM_001015878.1	NP_001015878.1	Q9UQB9	AURKC_HUMAN	aurora kinase C	240	Protein kinase.				cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(1)|large_intestine(9)|lung(9)|ovary(3)|prostate(1)|stomach(1)	25		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		TCCACCCTTTGAGAGCGCCTC	0.542000													30	50					0	0	1	0	0
MARK1	4139	broad.mit.edu	37	1	220777454	220777454	+	Missense_Mutation	SNP	A	A	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:220777454A>T	ENST00000402574.1	+	6	1067	c.65A>T	c.(64-66)aAa>aTa	p.K22I	MARK1_ENST00000366918.4_Missense_Mutation_p.K135I|MARK1_ENST00000366917.4_Missense_Mutation_p.K157I	NM_018650.3	NP_061120.3	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	157					intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(12)|lung(22)|ovary(4)|pancreas(1)|skin(3)|stomach(3)|urinary_tract(1)	63				GBM - Glioblastoma multiforme(131;0.0407)		ATGAAAGAGAAAGAGGCCCGT	0.353000													25	70					0	0	1	0	0
PROCA1	147011	broad.mit.edu	37	17	27031199	27031199	+	Missense_Mutation	SNP	C	C	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr17:27031199C>A	ENST00000301039.2	-	4	581	c.388G>T	c.(388-390)Gtg>Ttg	p.V130L	PROCA1_ENST00000581289.1_Missense_Mutation_p.Q41H|PROCA1_ENST00000439862.3_Missense_Mutation_p.V132L|PROCA1_ENST00000579650.1_5'UTR	NM_152465.1	NP_689678.1	Q8NCQ7	PRCA1_HUMAN	protein interacting with cyclin A1	158					lipid catabolic process		calcium ion binding|phospholipase A2 activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(7)|lung(4)|ovary(1)|urinary_tract(1)	16	Lung NSC(42;0.00431)					TGGTGGATCACTGCCACAGAG	0.567000													21	32					1.01871e-10	1.06569e-10	1	1	0
DCP2	167227	broad.mit.edu	37	5	112339742	112339742	+	Missense_Mutation	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr5:112339742C>T	ENST00000389063.2	+	8	1108	c.910C>T	c.(910-912)Cat>Tat	p.H304Y	DCP2_ENST00000543319.1_Missense_Mutation_p.H93Y|DCP2_ENST00000515408.1_Missense_Mutation_p.H304Y	NM_152624.5	NP_689837	Q8IU60	DCP2_HUMAN	decapping mRNA 2	304					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus|RNA-induced silencing complex	exoribonuclease activity, producing 5'-phosphomonoesters|manganese ion binding|protein binding|RNA binding			endometrium(3)|large_intestine(6)|lung(1)	10		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		OV - Ovarian serous cystadenocarcinoma(64;6.98e-08)|Epithelial(69;7.87e-08)|all cancers(49;1.06e-05)|COAD - Colon adenocarcinoma(37;0.0123)|Colorectal(14;0.0171)		ATATAATAATCATTCTGAAAT	0.388000													45	47					0	0	1	0	0
MFSD4	148808	broad.mit.edu	37	1	205553193	205553193	+	Silent	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:205553193A>G	ENST00000367147.4	+	4	894	c.801A>G	c.(799-801)acA>acG	p.T267T	MFSD4_ENST00000539267.1_Silent_p.T267T|MFSD4_ENST00000536357.1_Silent_p.T180T	NM_181644.4	NP_857595.3	Q8N468	MFSD4_HUMAN	major facilitator superfamily domain containing 4	267					transmembrane transport	integral to membrane				central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			CCTTGGAGACACAGCCTCCTG	0.572000													3	46					0	0	1	0	0
JMJD1C	221037	broad.mit.edu	37	10	64967851	64967851	+	Missense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr10:64967851G>A	ENST00000399262.2	-	10	3796	c.3578C>T	c.(3577-3579)tCt>tTt	p.S1193F	JMJD1C_ENST00000399251.1_Missense_Mutation_p.S974F|JMJD1C_ENST00000402544.1_Missense_Mutation_p.S974F|JMJD1C_ENST00000542921.1_Missense_Mutation_p.S1011F	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	1193					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					TGTATTTGTAGAAGAAACTGT	0.433000													27	149					0	0	1	0	0
STRIP2	57464	broad.mit.edu	37	7	129102807	129102807	+	Splice_Site	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr7:129102807G>A	ENST00000249344.2	+	14	1517	c.1477G>A	c.(1477-1479)Ggg>Agg	p.G493R	STRIP2_ENST00000435494.2_Splice_Site_p.G493R	NM_020704.2	NP_065755.1			striatin interacting protein 2																		CTTGCCATAGGGGGAAGAGGT	0.498000													23	54					0	0	1	0	0
ACAP3	116983	broad.mit.edu	37	1	1233313	1233313	+	Splice_Site	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:1233313C>T	ENST00000354700.5	-	14	1219	c.1017G>A	c.(1015-1017)aaG>aaA	p.K339K	ACAP3_ENST00000353662.3_Splice_Site_p.K297K|ACAP3_ENST00000379037.2_5'UTR	NM_030649.2	NP_085152.2	Q96P50	ACAP3_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 3	339	PH.				filopodium assembly|regulation of ARF GTPase activity|signal transduction		ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			endometrium(3)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	14						GCATGCAGCTCCTGCAGGCAG	0.701000													6	27					0	0	1	0	0
SSNA1	8636	broad.mit.edu	37	9	140083666	140083666	+	Silent	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr9:140083666T>C	ENST00000322310.5	+	2	281	c.201T>C	c.(199-201)tcT>tcC	p.S67S	SSNA1_ENST00000459860.1_3'UTR	NM_003731.2	NP_003722.2	O43805	SSNA1_HUMAN	Sjogren syndrome nuclear autoantigen 1	67					G2/M transition of mitotic cell cycle	centrosome|cytosol|nucleus				breast(2)|kidney(1)|large_intestine(1)|lung(2)	6	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.43e-05)|Epithelial(140;0.00087)		AGATTGCCTCTCGCAACGAGT	0.647000													19	51					0	0	1	0	0
ABCD2	225	broad.mit.edu	37	12	40010952	40010952	+	Nonsense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:40010952G>A	ENST00000308666.3	-	2	1093	c.958C>T	c.(958-960)Cag>Tag	p.Q320*		NM_005164.3	NP_005155.1	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D (ALD), member 2	320	ABC transmembrane type-1.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(24)|ovary(2)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	52						TAACTTTTCTGAAGTTGTTTC	0.303000													4	46					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121348870	121348870	+	Nonsense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr11:121348870C>G	ENST00000260197.7	+	3	575	c.446C>G	c.(445-447)tCa>tGa	p.S149*	SORL1_ENST00000532451.1_3'UTR	NM_003105.5	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	149					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		AAGAAAATTTCAGACAAGTTA	0.438000													27	46					0	0	1	0	0
NPHS1	4868	broad.mit.edu	37	19	36333175	36333175	+	Silent	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:36333175G>C	ENST00000378910.5	-	19	2513	c.2514C>G	c.(2512-2514)ccC>ccG	p.P838P	NPHS1_ENST00000353632.6_Silent_p.P838P	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	838	Ig-like C2-type 8.				cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GCTCCACCTGGGGGGCAACTG	0.597000													6	20					0	0	1	0	0
ZNF154	7710	broad.mit.edu	37	19	58213188	58213188	+	Nonsense_Mutation	SNP	T	T	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:58213188T>A	ENST00000512439.2	-	3	1325	c.1129A>T	c.(1129-1131)Aga>Tga	p.R377*	AC003006.7_ENST00000599221.1_Intron|AC003006.7_ENST00000594684.1_Intron|ZNF551_ENST00000596085.1_Intron|ZNF154_ENST00000426889.1_Nonsense_Mutation_p.R377*			Q13106	ZN154_HUMAN	zinc finger protein 154	377						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(3)	12		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GTGTGAACTCTCTGGTGTTTT	0.498000													25	144					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42224508	42224508	+	Silent	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr6:42224508T>C	ENST00000541110.1	-	12	3166	c.2598A>G	c.(2596-2598)gaA>gaG	p.E866E	TRERF1_ENST00000372917.4_Silent_p.E763E|TRERF1_ENST00000340840.2_Silent_p.E763E|TRERF1_ENST00000372922.4_Silent_p.E846E|TRERF1_ENST00000354325.2_Silent_p.E763E			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	846	ELM2.|Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GCAAAGCAAATTCAGAATTGG	0.438000													41	50					0	0	1	0	0
LAMP3	27074	broad.mit.edu	37	3	182853668	182853668	+	Silent	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:182853668A>G	ENST00000265598.3	-	5	1209	c.954T>C	c.(952-954)atT>atC	p.I318I	LAMP3_ENST00000466939.1_Silent_p.I294I	NM_014398.3	NP_055213.2	Q9UQV4	LAMP3_HUMAN	lysosomal-associated membrane protein 3	318			I -> V (in dbSNP:rs482912).		cell proliferation	integral to membrane|lysosomal membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(9)|ovary(2)|prostate(2)	28	all_cancers(143;9.14e-14)|Ovarian(172;0.0355)		all cancers(12;2.91e-44)|Epithelial(37;5.52e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;4.16e-21)			TTCCTTGGTAAATTGTCTCTG	0.527000													56	199					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	150840605	150840605	+	Silent	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:150840605A>G	ENST00000474524.1	+	3	278	c.240A>G	c.(238-240)aaA>aaG	p.K80K	MED12L_ENST00000309237.4_Silent_p.K80K|MED12L_ENST00000422248.2_Silent_p.K80K|MED12L_ENST00000273432.4_Silent_p.K80K	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	80					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TAGCTGAGAAACTGAAGCTTA	0.378000													11	38					0	0	1	0	0
FGFR1	2260	broad.mit.edu	37	8	38271525	38271525	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr8:38271525C>G	ENST00000447712.2	-	17	3144	c.2203G>C	c.(2203-2205)Gac>Cac	p.D735H	FGFR1_ENST00000397108.4_Missense_Mutation_p.D733H|FGFR1_ENST00000532791.1_Missense_Mutation_p.D733H|FGFR1_ENST00000356207.5_Missense_Mutation_p.D646H|FGFR1_ENST00000341462.5_Missense_Mutation_p.D735H|FGFR1_ENST00000335922.5_Missense_Mutation_p.D725H|FGFR1_ENST00000326324.6_Missense_Mutation_p.D644H|FGFR1_ENST00000397113.2_Missense_Mutation_p.D733H|FGFR1_ENST00000397091.5_Missense_Mutation_p.D733H|FGFR1_ENST00000397103.1_Missense_Mutation_p.D646H|FGFR1_ENST00000425967.3_Missense_Mutation_p.D766H	NM_001174063.1|NM_015850.3|NM_023110.2	NP_001167534.1|NP_056934.2|NP_075598.2	P11362	FGFR1_HUMAN	fibroblast growth factor receptor 1	735	Protein kinase.				axon guidance|cell growth|insulin receptor signaling pathway|MAPKKK cascade|positive regulation of cell proliferation|skeletal system development	extracellular region|integral to plasma membrane|membrane fraction	ATP binding|fibroblast growth factor receptor activity|heparin binding|protein homodimerization activity		FGFR1/ZNF703(2)	breast(2)|central_nervous_system(7)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(18)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(2)	50	all_cancers(2;9.05e-47)|all_epithelial(2;2.64e-50)|all_lung(3;1.71e-23)|Lung NSC(2;3.61e-23)|Colorectal(12;0.000442)	Breast(189;1.48e-05)|all_lung(54;0.00354)|Lung NSC(58;0.0138)|Hepatocellular(245;0.065)	Epithelial(3;3.96e-34)|all cancers(3;3.06e-30)|BRCA - Breast invasive adenocarcinoma(5;2.28e-21)|COAD - Colon adenocarcinoma(9;0.24)		Palifermin(DB00039)	TGCCAGCAGTCCCGCATCATC	0.597000		1	T	"""BCR, FOP, ZNF198, CEP1"""	"""MPD, NHL"""		"""Pfeiffer syndrome, Kallman syndrome"""						13	3					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414346	20414346	+	Silent	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr9:20414346G>A	ENST00000380338.4	-	5	784	c.498C>T	c.(496-498)agC>agT	p.S166S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S163S|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	166	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S166S(4)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctactgctgctgctgc	0.527000			T	MLL	ALL								4	58					0	0	1	0	0
KIRREL	55243	broad.mit.edu	37	1	158061339	158061339	+	Silent	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:158061339A>G	ENST00000368172.1	+	7	918	c.906A>G	c.(904-906)gaA>gaG	p.E302E	KIRREL_ENST00000416935.2_Silent_p.E388E|KIRREL_ENST00000359209.6_Silent_p.E488E|KIRREL_ENST00000360089.4_Silent_p.E324E|KIRREL_ENST00000368173.3_Silent_p.E504E|KIRREL_ENST00000392272.2_Silent_p.E385E			Q96J84	KIRR1_HUMAN	kin of IRRE like (Drosophila)	488						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|prostate(5)|skin(3)|stomach(1)	38	all_hematologic(112;0.0378)					TCCAGCTGGAAGAGCGAGGTG	0.597000													3	46					0	0	1	0	0
SLC18A3	6572	broad.mit.edu	37	10	50819507	50819507	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr10:50819507A>G	ENST00000374115.3	+	1	1161	c.721A>G	c.(721-723)Aag>Gag	p.K241E	CHAT_ENST00000339797.1_Intron	NM_003055.2	NP_003046.2	Q16572	VACHT_HUMAN	solute carrier family 18 (vesicular acetylcholine transporter), member 3	241					neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	43						GTTCGCCGGCAAGCGCGTGCC	0.672000													3	26					0	0	1	0	0
ZNF135	7694	broad.mit.edu	37	19	58570653	58570653	+	Missense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:58570653G>A	ENST00000401053.4	+	1	47	c.44G>A	c.(43-45)cGc>cAc	p.R15H	ZNF135_ENST00000439855.2_5'UTR|ZNF135_ENST00000506786.1_5'UTR|ZNF135_ENST00000359978.6_Missense_Mutation_p.R15H|ZNF135_ENST00000511556.1_5'UTR|ZNF135_ENST00000313434.5_5'UTR	NM_001164529.1|NM_007134.1	NP_001158001.1|NP_009065.1	B4DHH9	B4DHH9_HUMAN	zinc finger protein 135	0					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(26)|ovary(1)|skin(1)|urinary_tract(1)	41		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		TGCCGGTGCCGCGGCCTTTGT	0.761000													5	31					0	0	1	0	0
LYN	4067	broad.mit.edu	37	8	56910944	56910944	+	Missense_Mutation	SNP	A	A	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr8:56910944A>C	ENST00000520220.2	+	11	1301	c.1027A>C	c.(1027-1029)Att>Ctt	p.I343L	LYN_ENST00000420292.1_3'UTR|LYN_ENST00000519728.1_Missense_Mutation_p.I364L	NM_001111097.2	NP_001104567.1	P07948	LYN_HUMAN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	364	Protein kinase.				erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	22		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			GAAGAACTACATTCACCGGGA	0.448000													14	46					0	0	1	0	0
CDH17	1015	broad.mit.edu	37	8	95158244	95158244	+	Silent	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr8:95158244A>G	ENST00000027335.3	-	15	2203	c.2079T>C	c.(2077-2079)gaT>gaC	p.D693D	CDH17_ENST00000450165.2_Silent_p.D693D|CDH17_ENST00000441892.2_Silent_p.D479D	NM_004063.3	NP_004054.3	Q12864	CAD17_HUMAN	cadherin 17, LI cadherin (liver-intestine)	693	Cadherin 7.					integral to membrane	calcium ion binding			NS(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(4)|stomach(2)	52	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			AGTGCTGATCATCATCAGTAG	0.488000													50	26					0	0	1	0	0
ABCA2	20	broad.mit.edu	37	9	139906744	139906744	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr9:139906744T>C	ENST00000265662.5	-	33	5419	c.5272A>G	c.(5272-5274)Aag>Gag	p.K1758E	ABCA2_ENST00000341511.6_Missense_Mutation_p.K1758E|ABCA2_ENST00000371605.3_Missense_Mutation_p.K1757E			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	1757					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CCCTTGCTCTTGGGCAGGTTG	0.647000													5	14					0	0	1	0	0
TRIM14	9830	broad.mit.edu	37	9	100862390	100862390	+	Silent	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr9:100862390T>C	ENST00000341469.2	-	3	369	c.360A>G	c.(358-360)ttA>ttG	p.L120L	TRIM14_ENST00000375098.3_Silent_p.L120L|TRIM14_ENST00000342043.3_Silent_p.L120L	NM_014788.2	NP_055603.2	Q14142	TRI14_HUMAN	tripartite motif containing 14	120						cytoplasm|intracellular	zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	9		Acute lymphoblastic leukemia(62;0.0559)				CGTCAAGTAGTAATCTGAGTT	0.453000													82	73					0	0	1	0	0
SSU72	29101	broad.mit.edu	37	1	1500213	1500213	+	Missense_Mutation	SNP	T	T	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:1500213T>G	ENST00000359060.4	-	2	190	c.164A>C	c.(163-165)tAt>tCt	p.Y55S	SSU72_ENST00000291386.3_Missense_Mutation_p.Y55S			Q9NP77	SSU72_HUMAN	SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)	55					mRNA processing	cytoplasm|nucleus	phosphoprotein phosphatase activity			large_intestine(2)|lung(5)	7	all_cancers(77;0.00125)|all_epithelial(69;0.000703)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.03e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;5.04e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.72e-23)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;0.000188)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|STAD - Stomach adenocarcinoma(132;0.00645)|BRCA - Breast invasive adenocarcinoma(365;0.00837)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		TTTGAAATCATAAACATTGGG	0.478000													18	63					0	0	1	0	0
TAF6	6878	broad.mit.edu	37	7	99711931	99711931	+	Missense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr7:99711931G>A	ENST00000472509.1	-	1	250	c.73C>T	c.(73-75)Cac>Tac	p.H25Y	TAF6_ENST00000453269.2_Intron|TAF6_ENST00000418432.2_Intron|TAF6_ENST00000452041.1_Intron|TAF6_ENST00000344095.4_Intron|TAF6_ENST00000437822.2_Intron|TAF6_ENST00000497233.1_Intron			P49848	TAF6_HUMAN	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa	640					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(2)	26	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AAAGAAACGTGAGACACAGGG	0.577000													8	11					0	0	1	0	0
ERAP1	51752	broad.mit.edu	37	5	96139222	96139222	+	Silent	SNP	G	G	A	rs113481697	byFrequency	TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr5:96139222G>A	ENST00000296754.3	-	2	665	c.408C>T	c.(406-408)ccC>ccT	p.P136P	ERAP1_ENST00000443439.2_Silent_p.P136P	NM_016442.3	NP_057526.3	Q9NZ08	ERAP1_HUMAN	endoplasmic reticulum aminopeptidase 1	136					angiogenesis|antigen processing and presentation of endogenous peptide antigen via MHC class I|fat cell differentiation|membrane protein ectodomain proteolysis|regulation of blood pressure|regulation of innate immune response|response to bacterium	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|integral to membrane	aminopeptidase activity|interleukin-1, Type II receptor binding|interleukin-6 receptor binding|metalloexopeptidase activity|zinc ion binding			endometrium(7)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|stomach(2)	19		all_cancers(142;1.75e-06)|all_epithelial(76;3.08e-09)|all_lung(232;0.000435)|Lung NSC(167;0.000601)|Ovarian(225;0.024)|Colorectal(57;0.0432)|Breast(839;0.244)		all cancers(79;7.26e-15)|COAD - Colon adenocarcinoma(37;0.071)		GGAGGGGCTCGGGAGCCAGCA	0.562000													16	53					0	0	1	0	0
LYN	4067	broad.mit.edu	37	8	56910945	56910945	+	Missense_Mutation	SNP	T	T	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr8:56910945T>A	ENST00000520220.2	+	11	1302	c.1028T>A	c.(1027-1029)aTt>aAt	p.I343N	LYN_ENST00000420292.1_3'UTR|LYN_ENST00000519728.1_Missense_Mutation_p.I364N	NM_001111097.2	NP_001104567.1	P07948	LYN_HUMAN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	364	Protein kinase.				erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	22		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			AAGAACTACATTCACCGGGAC	0.453000													14	46					0	0	1	0	0
PTGS1	5742	broad.mit.edu	37	9	125145851	125145851	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr9:125145851C>G	ENST00000362012.2	+	8	831	c.826C>G	c.(826-828)Cga>Gga	p.R276G	PTGS1_ENST00000223423.4_Missense_Mutation_p.R276G|PTGS1_ENST00000373698.5_Missense_Mutation_p.R167G|PTGS1_ENST00000540753.1_Missense_Mutation_p.R251G	NM_000962.3|NM_001271164.1|NM_001271367.1|NM_080591.2	NP_000953.2|NP_001258093.1|NP_001258296.1|NP_542158.1	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	276					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			large_intestine(3)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	8					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	GCACTACCCCCGAGGCATCCC	0.632000													9	33					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9015692	9015692	+	Nonsense_Mutation	SNP	T	T	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:9015692T>A	ENST00000397910.4	-	29	38334	c.38131A>T	c.(38131-38133)Aag>Tag	p.K12711*		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12713	SEA 5.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCCTCGTACTTCAGGTTGGTG	0.507000													29	68					0	0	1	0	0
OR5B17	219965	broad.mit.edu	37	11	58125905	58125905	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr11:58125905A>G	ENST00000357377.3	-	1	637	c.638T>C	c.(637-639)tTg>tCg	p.L213S		NM_001005489.1	NP_001005489.1	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B, member 17	213					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				ATAGGAAATCAAGGTAACAAG	0.388000													14	22					0	0	1	0	0
TDRD7	23424	broad.mit.edu	37	9	100222920	100222920	+	Missense_Mutation	SNP	A	A	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr9:100222920A>C	ENST00000355295.4	+	7	1611	c.1316A>C	c.(1315-1317)gAa>gCa	p.E439A	TDRD7_ENST00000422139.2_Missense_Mutation_p.E365A	NM_014290.2	NP_055105.2	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	439	Lotus/OST-HTH 3.				lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Acute lymphoblastic leukemia(62;0.158)				CAGGTAGAAGAAAGCATTGCT	0.413000													13	101					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152283965	152283965	+	Missense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:152283965G>A	ENST00000368799.1	-	3	3432	c.3397C>T	c.(3397-3399)Cgg>Tgg	p.R1133W	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1133	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCCTGGTCCGCCCATGGGCA	0.597000									Ichthyosis				81	162					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124827703	124827703	+	Missense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:124827703G>A	ENST00000356219.3	-	34	4960	c.4805C>T	c.(4804-4806)tCc>tTc	p.S1602F	NCOR2_ENST00000405201.1_Missense_Mutation_p.S1595F|NCOR2_ENST00000397355.1_Missense_Mutation_p.S1586F|NCOR2_ENST00000404621.1_Missense_Mutation_p.S1585F|NCOR2_ENST00000429285.2_Missense_Mutation_p.S1585F|NCOR2_ENST00000404121.2_Missense_Mutation_p.S1156F	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	1603					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GCTGTGCGGGGACTTGGCGAT	0.652000													8	20					0	0	1	0	0
CER1	9350	broad.mit.edu	37	9	14722421	14722421	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr9:14722421C>G	ENST00000380911.3	-	1	294	c.250G>C	c.(250-252)Ggc>Cgc	p.G84R		NM_005454.2	NP_005445.1	O95813	CER1_HUMAN	cerberus 1, DAN family BMP antagonist	84					BMP signaling pathway	extracellular space	cytokine activity			endometrium(2)|large_intestine(3)|lung(6)	11				GBM - Glioblastoma multiforme(50;3.16e-06)		CAGAACCTGCCAAATCTGGAC	0.562000													13	32					0	0	1	0	0
ABCC5	10057	broad.mit.edu	37	3	183665155	183665155	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:183665155A>G	ENST00000334444.6	-	23	3611	c.3371T>C	c.(3370-3372)aTt>aCt	p.I1124T	ABCC5_ENST00000265586.6_Missense_Mutation_p.I1081T	NM_005688.2	NP_005679.2	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	1124	ABC transmembrane type-1 2.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GGCTGGGGGAATCTGCCCGTG	0.577000													7	11					0	0	1	0	0
SLC9B1	150159	broad.mit.edu	37	4	103822285	103822285	+	Missense_Mutation	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr4:103822285C>T	ENST00000296422.7	-	12	1678	c.1537G>A	c.(1537-1539)Gaa>Aaa	p.E513K	SLC9B1_ENST00000512651.2_5'UTR|SLC9B1_ENST00000394789.3_Intron	NM_139173.3	NP_631912	Q4ZJI4	NHDC1_HUMAN	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	513						integral to membrane	solute:hydrogen antiporter activity										TAATGATGTTCTAATGTTGAC	0.368000													21	67					0	0	1	0	0
CENPJ	55835	broad.mit.edu	37	13	25457446	25457446	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr13:25457446T>C	ENST00000381884.4	-	17	4071	c.3886A>G	c.(3886-3888)Aag>Gag	p.K1296E	CENPJ_ENST00000545981.1_3'UTR	NM_018451.4	NP_060921.3	Q9HC77	CENPJ_HUMAN	centromere protein J	1296					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			endometrium(5)|kidney(4)|large_intestine(14)|lung(13)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		TCCCGTCTCTTGAACTGGGCA	0.363000													47	69					0	0	1	0	0
ACSBG1	23205	broad.mit.edu	37	15	78463808	78463808	+	Missense_Mutation	SNP	A	A	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr15:78463808A>C	ENST00000258873.4	-	14	2358	c.2153T>G	c.(2152-2154)tTt>tGt	p.F718C	ACSBG1_ENST00000560817.1_Missense_Mutation_p.F476C|IDH3A_ENST00000299518.2_3'UTR|ACSBG1_ENST00000541759.1_Missense_Mutation_p.F476C	NM_001199377.1|NM_015162.4	NP_001186306.1|NP_055977.3	Q96GR2	ACBG1_HUMAN	acyl-CoA synthetase bubblegum family member 1	718					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			endometrium(2)|kidney(2)|large_intestine(11)|liver(1)|lung(15)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	37						CTCTTGGTAAAAGGAGTCAAT	0.473000													7	36					0	0	1	0	0
NKD1	85407	broad.mit.edu	37	16	50667470	50667470	+	Silent	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr16:50667470C>G	ENST00000268459.3	+	10	1415	c.1191C>G	c.(1189-1191)ctC>ctG	p.L397L		NM_033119.4	NP_149110.1	Q969G9	NKD1_HUMAN	naked cuticle homolog 1 (Drosophila)	397					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|prostate(1)|urinary_tract(2)	23		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		TAGCCCCCCTCGGGCACAAGA	0.726000													4	9					0	0	1	0	0
DIAPH2	1730	broad.mit.edu	37	X	96854270	96854270	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chrX:96854270T>C	ENST00000324765.8	+	27	3607	c.3260T>C	c.(3259-3261)tTg>tCg	p.L1087S	DIAPH2-AS1_ENST00000445414.1_RNA|DIAPH2_ENST00000373061.3_Missense_Mutation_p.L1087S|DIAPH2_ENST00000373054.4_Missense_Mutation_p.L1083S			O60879	DIAP2_HUMAN	diaphanous-related formin 2	1087					cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51						CGAGTACCTTTGGAAAGGTCA	0.353000													5	14					0	0	1	0	0
TSLP	85480	broad.mit.edu	37	5	110409248	110409248	+	Missense_Mutation	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr5:110409248C>T	ENST00000420978.2	+	4	1678	c.256C>T	c.(256-258)Ccc>Tcc	p.P86S	TSLP_ENST00000344895.3_Missense_Mutation_p.P86S|TSLP_ENST00000379706.4_5'UTR			Q969D9	TSLP_HUMAN	thymic stromal lymphopoietin	86						extracellular space	cytokine activity			breast(1)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|stomach(1)	11		all_cancers(142;2.72e-05)|all_epithelial(76;4.39e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0417)|Ovarian(225;0.0443)|Colorectal(57;0.0464)|all_lung(232;0.0507)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.24e-08)|Epithelial(69;1.54e-07)|all cancers(49;1.73e-05)|COAD - Colon adenocarcinoma(37;0.109)		AACCTTCAATCCCACCGCCGG	0.507000													104	24					0	0	1	0	0
SMO	6608	broad.mit.edu	37	7	128852186	128852186	+	Missense_Mutation	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr7:128852186C>T	ENST00000249373.3	+	12	2538	c.2258C>T	c.(2257-2259)cCg>cTg	p.P753L	RP11-286H14.8_ENST00000466717.1_RNA	NM_005631.4	NP_005622.1	Q99835	SMO_HUMAN	smoothened, frizzled family receptor	753					adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			biliary_tract(1)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(14)|liver(1)|lung(11)|pancreas(2)|prostate(1)|skin(20)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						CCCAGTGCACCGGCCCCCGTG	0.647000			Mis		skin basal cell								7	15					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105409960	105409960	+	Missense_Mutation	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr14:105409960G>C	ENST00000333244.5	-	7	11947	c.11828C>G	c.(11827-11829)gCc>gGc	p.A3943G	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3943						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ATCCAGCTTGGCTCCTGGGGC	0.612000													95	161					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124210218	124210218	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:124210218T>C	ENST00000360013.3	+	31	4757	c.4630T>C	c.(4630-4632)Ttc>Ctc	p.F1544L	KALRN_ENST00000460856.1_Missense_Mutation_p.F1535L|KALRN_ENST00000240874.3_Missense_Mutation_p.F1544L	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1544	PH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						TCCCTGCAAATTCGCCTTGTG	0.552000													9	20					0	0	1	0	0
DGKA	1606	broad.mit.edu	37	12	56334710	56334710	+	Silent	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:56334710A>G	ENST00000331886.5	+	13	1501	c.1047A>G	c.(1045-1047)aaA>aaG	p.K349K	DGKA_ENST00000549079.2_3'UTR|DGKA_ENST00000394147.1_Silent_p.K349K|DGKA_ENST00000551156.1_Silent_p.K349K	NM_001345.4	NP_001336.2	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	349					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(4)|pancreas(1)|skin(3)|urinary_tract(1)	25					Vitamin E(DB00163)	AAAATAGCAAAACAAGCCAGA	0.488000											OREG0021913	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	43					0	0	1	0	0
TRPC5	7224	broad.mit.edu	37	X	111090395	111090395	+	Missense_Mutation	SNP	C	C	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chrX:111090395C>A	ENST00000262839.2	-	6	2565	c.1647G>T	c.(1645-1647)gaG>gaT	p.E549D		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	549					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						AGTTGTTAGGCTCATCGATAG	0.393000													61	7					5.80444e-35	6.30154e-35	1	1	0
SLC13A4	26266	broad.mit.edu	37	7	135377080	135377080	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr7:135377080A>G	ENST00000354042.4	-	11	1900	c.1211T>C	c.(1210-1212)tTc>tCc	p.F404S	C7orf73_ENST00000422968.1_3'UTR	NM_012450.2	NP_036582.2	Q9UKG4	S13A4_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 4	404						integral to plasma membrane	sodium:sulfate symporter activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(2)	24						CTTTTCAAAGAAAGAATCCCA	0.458000													17	18					0	0	1	0	0
TPH2	121278	broad.mit.edu	37	12	72335387	72335387	+	Silent	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:72335387A>G	ENST00000333850.3	+	2	270	c.129A>G	c.(127-129)aaA>aaG	p.K43K	TPH2_ENST00000546576.1_3'UTR	NM_173353.3	NP_775489.2	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	43					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	41					L-Tryptophan(DB00150)	ACTCTGGCAAAAATGACGACA	0.398000													35	7					0	0	1	0	0
DIP2A	23181	broad.mit.edu	37	21	47969717	47969717	+	Silent	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr21:47969717C>T	ENST00000318711.7	+	22	2742	c.2559C>T	c.(2557-2559)gaC>gaT	p.D853D	DIP2A_ENST00000400274.1_Silent_p.D848D|DIP2A_ENST00000457905.3_Silent_p.D852D|DIP2A_ENST00000417564.2_Silent_p.D852D|DIP2A_ENST00000427143.2_Silent_p.D788D	NM_001146116.1|NM_015151.3	NP_001139588.1|NP_055966.2	Q14689	DIP2A_HUMAN	DIP2 disco-interacting protein 2 homolog A (Drosophila)	852					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(22)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		TGCTGCACGACGACCGGATTG	0.627000													28	36					0	0	1	0	0
IFRD2	7866	broad.mit.edu	37	3	50327674	50327674	+	Silent	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:50327674G>A	ENST00000436390.1	-	7	812	c.315C>T	c.(313-315)tcC>tcT	p.S105S	IFRD2_ENST00000417626.2_Silent_p.S105S|IFRD2_ENST00000336089.4_Silent_p.S271S|IFRD2_ENST00000429673.2_Silent_p.S169S|IFRD2_ENST00000484043.1_5'UTR			Q12894	IFRD2_HUMAN	interferon-related developmental regulator 2	169							binding			breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)	14				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GGAGTAGGCGGGACGCTAGGG	0.647000													5	12					0	0	1	0	0
SLC43A2	124935	broad.mit.edu	37	17	1494614	1494614	+	Missense_Mutation	SNP	G	G	C	rs140076368		TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr17:1494614G>C	ENST00000301335.5	-	8	968	c.880C>G	c.(880-882)Ctg>Gtg	p.L294V	SLC43A2_ENST00000571650.1_Missense_Mutation_p.L294V|SLC43A2_ENST00000412517.3_Missense_Mutation_p.L157V|SLC43A2_ENST00000382147.4_Missense_Mutation_p.L294V|SLC43A2_ENST00000574274.1_5'UTR	NM_001284498.1|NM_001284499.1	NP_001271427.1|NP_001271428.1	Q8N370	LAT4_HUMAN	solute carrier family 43 (amino acid system L transporter), member 2						cellular nitrogen compound metabolic process|ion transport	integral to membrane|plasma membrane				endometrium(4)|large_intestine(4)|liver(1)|lung(2)|upper_aerodigestive_tract(1)	12				UCEC - Uterine corpus endometrioid carcinoma (25;0.0883)		GACAGGCACAGCTTGTGGCCC	0.682000													19	18					0	0	1	0	0
CRYGS	1427	broad.mit.edu	37	3	186257280	186257280	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:186257280T>C	ENST00000392499.2	-	3	467	c.128A>G	c.(127-129)gAa>gGa	p.E43G	CRYGS_ENST00000307944.5_Missense_Mutation_p.E43G	NM_017541.2	NP_060011.1	P22914	CRBS_HUMAN	crystallin, gamma S	43	Beta/gamma crystallin 'Greek key' 1.						structural constituent of eye lens			endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(2)	11	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.5e-22)	GBM - Glioblastoma multiforme(93;0.0906)		GGTGCCTCCTTCCACTTTAAT	0.478000													36	58					0	0	1	0	0
NKX2-2	4821	broad.mit.edu	37	20	21492642	21492642	+	Nonsense_Mutation	SNP	G	G	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr20:21492642G>T	ENST00000377142.4	-	2	1097	c.741C>A	c.(739-741)taC>taA	p.Y247*	NKX2-2-AS1_ENST00000549659.1_RNA	NM_002509.3	NP_002500.1	O95096	NKX22_HUMAN	NK2 homeobox 2	247					brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21						ACTGGGCGTTGTACTGCATGT	0.657000													8	22					0.000157383	0.000159231	1	1	0
CCDC176	80127	broad.mit.edu	37	14	74489747	74489747	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr14:74489747A>G	ENST00000394009.3	+	2	308	c.185A>G	c.(184-186)aAa>aGa	p.K62R	CCDC176_ENST00000489323.1_Intron	NM_025057.2	NP_079333.2			coiled-coil domain containing 176																		ATACTGGCAAAAAGTAATGAG	0.413000													4	13					0	0	1	0	0
PNMAL1	55228	broad.mit.edu	37	19	46974055	46974055	+	Missense_Mutation	SNP	T	T	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:46974055T>A	ENST00000313683.10	-	2	543	c.238A>T	c.(238-240)Agc>Tgc	p.S80C	PNMAL1_ENST00000602246.1_Intron|PNMAL1_ENST00000438932.2_Missense_Mutation_p.S80C	NM_001103149.1|NM_018215.3	NP_001096619.1|NP_060685.2	Q86V59	PNML1_HUMAN	paraneoplastic Ma antigen family-like 1	80			S -> T (in dbSNP:rs12610254).							cervix(1)|endometrium(2)|large_intestine(8)|lung(8)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		gggatggtgctcagattcaca	0.507000													15	56					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109687526	109687526	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr9:109687526C>G	ENST00000277225.5	+	3	1622	c.1333C>G	c.(1333-1335)Cct>Gct	p.P445A	ZNF462_ENST00000457913.1_Missense_Mutation_p.P445A			Q96JM2	ZN462_HUMAN	zinc finger protein 462	445					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						CCCCTTTTGTCCTTTCCTCAC	0.453000													62	52					0	0	1	0	0
FBXO34	55030	broad.mit.edu	37	14	55817981	55817981	+	Silent	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr14:55817981G>A	ENST00000313833.4	+	2	1118	c.873G>A	c.(871-873)ctG>ctA	p.L291L	FBXO34_ENST00000440021.1_Silent_p.L291L	NM_017943.3	NP_060413.2	Q9NWN3	FBX34_HUMAN	F-box protein 34	291										breast(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(3)	22						CTGAGTGCCTGAAGCGGCAGG	0.537000													29	50					0	0	1	0	0
DENND3	22898	broad.mit.edu	37	8	142176343	142176343	+	Silent	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr8:142176343C>T	ENST00000519811.1	+	12	1678	c.1608C>T	c.(1606-1608)tcC>tcT	p.S536S	DENND3_ENST00000424248.1_Silent_p.S404S|DENND3_ENST00000262585.2_Silent_p.S456S			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	456										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			AAAGAGCCTCCCGGAAGTCCT	0.522000													53	180					0	0	1	0	0
UBE2E3	10477	broad.mit.edu	37	2	181846866	181846866	+	Missense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:181846866G>A	ENST00000410062.4	+	2	490	c.97G>A	c.(97-99)Gaa>Aaa	p.E33K	UBE2E3_ENST00000392415.2_Missense_Mutation_p.E33K|UBE2E3_ENST00000602710.1_Missense_Mutation_p.E33K|UBE2E3_ENST00000602475.1_Missense_Mutation_p.E33K|UBE2E3_ENST00000602632.1_Missense_Mutation_p.E33K|UBE2E3_ENST00000602959.1_Missense_Mutation_p.E33K	NM_006357.2	NP_006348.1	Q969T4	UB2E3_HUMAN	ubiquitin-conjugating enzyme E2E 3	33					protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|regulation of growth	cytoplasm|nucleolus	ATP binding|protein binding|ubiquitin-protein ligase activity			breast(2)|endometrium(3)|lung(4)|ovary(1)|skin(1)	11						TCCAGAGCCTGAAGAACAAGA	0.507000													49	37					0	0	1	0	0
OR52H1	390067	broad.mit.edu	37	11	5565861	5565861	+	Missense_Mutation	SNP	A	A	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr11:5565861A>T	ENST00000322653.4	-	1	918	c.893T>A	c.(892-894)aTg>aAg	p.M298K	HBG2_ENST00000380259.2_Intron	NM_001005289.1	NP_001005289.1	Q8NGJ2	O52H1_HUMAN	olfactory receptor, family 52, subfamily H, member 1	298					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(1)|skin(2)	20		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;5.33e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCCGTAAACCATGGGGTTGAG	0.428000													17	45					0	0	1	0	0
C11orf49	79096	broad.mit.edu	37	11	47074021	47074021	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr11:47074021T>C	ENST00000395460.2	+	3	270	c.232T>C	c.(232-234)Ttt>Ctt	p.F78L	C11orf49_ENST00000378615.3_Missense_Mutation_p.F78L|C11orf49_ENST00000378618.2_Missense_Mutation_p.F78L|C11orf49_ENST00000543718.1_Intron|C11orf49_ENST00000527268.1_3'UTR|C11orf49_ENST00000278460.7_Missense_Mutation_p.F78L|C11orf49_ENST00000536126.1_5'UTR	NM_001003676.1	NP_001003676.1	Q9H6J7	CK049_HUMAN	chromosome 11 open reading frame 49	78										central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|skin(1)	11						TAGGGTATCATTTTTACGGGC	0.453000													30	56					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117663661	117663661	+	Missense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr6:117663661G>A	ENST00000368508.3	-	28	4769	c.4571C>T	c.(4570-4572)tCa>tTa	p.S1524L	ROS1_ENST00000368507.3_Missense_Mutation_p.S1518L|GOPC_ENST00000467125.1_Intron	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	1524	Fibronectin type-III 6.				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		CATGTATGTTGAAAATGGTTG	0.274000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								11	20					0	0	1	0	0
KLHL40	131377	broad.mit.edu	37	3	42727138	42727138	+	Missense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:42727138G>A	ENST00000287777.4	+	1	128	c.28G>A	c.(28-30)Gag>Aag	p.E10K		NM_152393.2	NP_689606.2			kelch-like family member 40																		GCAGGCGGAGGAGCAGCGGTT	0.657000													6	3					0	0	1	0	0
UMOD	7369	broad.mit.edu	37	16	20352462	20352462	+	Missense_Mutation	SNP	G	G	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr16:20352462G>T	ENST00000396134.2	-	8	1750	c.1627C>A	c.(1627-1629)Ccc>Acc	p.P543T	UMOD_ENST00000570331.1_5'UTR|UMOD_ENST00000396142.2_Missense_Mutation_p.P510T|UMOD_ENST00000396138.4_Missense_Mutation_p.P559T|UMOD_ENST00000570689.1_Missense_Mutation_p.P510T|UMOD_ENST00000302509.4_Missense_Mutation_p.P510T|UMOD_ENST00000424589.1_Missense_Mutation_p.P543T	NM_001278614.1	NP_001265543.1	P07911	UROM_HUMAN	uromodulin	510	ZP.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			endometrium(5)|kidney(1)|large_intestine(7)|lung(20)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						TTGCTACTGGGTGTGGCATAG	0.542000													7	13					0.00307968	0.00310127	1	1	0
KANK3	256949	broad.mit.edu	37	19	8397948	8397948	+	Missense_Mutation	SNP	T	T	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:8397948T>A	ENST00000330915.3	-	7	1951	c.1886A>T	c.(1885-1887)tAc>tTc	p.Y629F	KANK3_ENST00000593649.1_Missense_Mutation_p.Y629F	NM_198471.2	NP_940873.2	Q6NY19	KANK3_HUMAN	KN motif and ankyrin repeat domains 3	629										breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	9						GGACACACTGTAGTGCAGGGC	0.667000													4	10					0	0	1	0	0
TFDP2	7029	broad.mit.edu	37	3	141697507	141697507	+	Missense_Mutation	SNP	C	C	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:141697507C>A	ENST00000499676.2	-	7	862	c.191G>T	c.(190-192)gGa>gTa	p.G64V	TFDP2_ENST00000317104.7_Missense_Mutation_p.G48V|TFDP2_ENST00000495310.1_Missense_Mutation_p.G28V|TFDP2_ENST00000486111.1_Missense_Mutation_p.G64V|TFDP2_ENST00000464782.1_5'UTR|TFDP2_ENST00000467072.1_Missense_Mutation_p.G64V|TFDP2_ENST00000397991.4_Missense_Mutation_p.G97V|TFDP2_ENST00000489671.1_Missense_Mutation_p.G125V|TFDP2_ENST00000477292.1_5'UTR|TFDP2_ENST00000310282.6_Missense_Mutation_p.G64V|TFDP2_ENST00000479040.1_Missense_Mutation_p.G64V	NM_001178139.1	NP_001171610.1	Q14188	TFDP2_HUMAN	transcription factor Dp-2 (E2F dimerization partner 2)	125			I -> T.		cell cycle	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|transcription factor binding			kidney(1)|upper_aerodigestive_tract(2)	3						ATTTTTATCTCCTTTTTTGCT	0.338000													11	38					6.42651e-13	6.77219e-13	1	1	0
TPST1	8460	broad.mit.edu	37	7	65751532	65751532	+	Missense_Mutation	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr7:65751532G>C	ENST00000304842.5	+	3	1305	c.880G>C	c.(880-882)Gtc>Ctc	p.V294L	TPST1_ENST00000480281.1_3'UTR	NM_003596.3	NP_003587.1	O60507	TPST1_HUMAN	tyrosylprotein sulfotransferase 1	294					inflammatory response|peptidyl-tyrosine sulfation	Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity			NS(1)|biliary_tract(1)|breast(1)|kidney(3)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11						AATCAAGCCAGTCAATGTAGG	0.353000													12	34					0	0	1	0	0
NEFH	4744	broad.mit.edu	37	22	29885132	29885132	+	Silent	SNP	A	A	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr22:29885132A>T	ENST00000310624.6	+	4	1536	c.1503A>T	c.(1501-1503)acA>acT	p.T501T		NM_021076.3	NP_066554.2	P12036	NFH_HUMAN	neurofilament, heavy polypeptide	501	Tail.				cell death|nervous system development	neurofilament				cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(3)	30						aagaagAAACAAAGTCTCCCC	0.542000													14	15					0	0	1	0	0
TTLL5	23093	broad.mit.edu	37	14	76248832	76248832	+	Missense_Mutation	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr14:76248832C>T	ENST00000298832.9	+	25	2723	c.2518C>T	c.(2518-2520)Cac>Tac	p.H840Y	TTLL5_ENST00000556893.1_Missense_Mutation_p.H391Y|TTLL5_ENST00000557636.1_Missense_Mutation_p.H854Y|TTLL5_ENST00000555422.1_3'UTR|TTLL5_ENST00000554510.1_Missense_Mutation_p.H349Y	NM_015072.4	NP_055887.3	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	840					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			NS(2)|breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(3)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	50				BRCA - Breast invasive adenocarcinoma(234;0.029)		TATTTCAGATCACCCTGAGAC	0.333000													13	21					0	0	1	0	0
UBA7	7318	broad.mit.edu	37	3	49848455	49848455	+	Missense_Mutation	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:49848455C>T	ENST00000333486.3	-	10	1350	c.1192G>A	c.(1192-1194)Gat>Aat	p.D398N		NM_003335.2	NP_003326.2	P41226	UBA7_HUMAN	ubiquitin-like modifier activating enzyme 7	398	2 approximate repeats.				ISG15-protein conjugation|negative regulation of type I interferon production	cytosol	ATP binding|ISG15 activating enzyme activity|ligase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(15)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;3.58e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		AGCTCCCCATCTTCCGGAAGA	0.567000													10	30					0	0	1	0	0
PDE11A	50940	broad.mit.edu	37	2	178936253	178936253	+	Splice_Site	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:178936253C>T	ENST00000286063.6	-	1	1229	c.912G>A	c.(910-912)caG>caA	p.Q304Q	PDE11A_ENST00000358450.4_Intron	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A		GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			AAAGTCCTACCTGGTAGGCAT	0.512000									Primary Pigmented Nodular Adrenocortical Disease, Familial				21	44					0	0	1	0	0
PPAPDC3	84814	broad.mit.edu	37	9	134165467	134165467	+	Missense_Mutation	SNP	C	C	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr9:134165467C>A	ENST00000372264.3	+	1	387	c.83C>A	c.(82-84)cCc>cAc	p.P28H	PPAPDC3_ENST00000372261.1_Missense_Mutation_p.P28H	NM_032728.3	NP_116117.3	Q8NBV4	PPAC3_HUMAN	phosphatidic acid phosphatase type 2 domain containing 3	28						endoplasmic reticulum membrane|integral to membrane|nuclear envelope	hydrolase activity			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	16	all_hematologic(7;0.0119)			OV - Ovarian serous cystadenocarcinoma(145;1.22e-05)|Epithelial(140;0.000173)		CTGAACCAGCCCCCCAAGGGG	0.716000													6	13					0.0293803	0.0293803	1	1	0
CDK17	5128	broad.mit.edu	37	12	96707122	96707122	+	Missense_Mutation	SNP	T	T	C	rs140389429		TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:96707122T>C	ENST00000261211.3	-	4	997	c.394A>G	c.(394-396)Ata>Gta	p.I132V	CDK17_ENST00000542666.1_Missense_Mutation_p.I79V|CDK17_ENST00000543119.2_Missense_Mutation_p.I132V	NM_001170464.2|NM_002595.4	NP_001163935.1|NP_002586.2	Q00537	CDK17_HUMAN	cyclin-dependent kinase 17	132							ATP binding|cyclin-dependent protein kinase activity			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(6)|lung(11)|ovary(4)|prostate(2)|skin(1)	37						CGTCTATGTATACGATTTCTG	0.358000													15	35					0	0	1	0	0
MRVI1	10335	broad.mit.edu	37	11	10626034	10626034	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr11:10626034C>G	ENST00000547195.1	-	12	1888	c.1388G>C	c.(1387-1389)aGa>aCa	p.R463T	LYVE1_ENST00000531706.1_Intron|MRVI1_ENST00000552103.1_Missense_Mutation_p.R463T|MRVI1_ENST00000423302.2_Missense_Mutation_p.R554T|MRVI1_ENST00000558540.1_Missense_Mutation_p.R239T|MRVI1_ENST00000531107.1_Missense_Mutation_p.R546T|MRVI1_ENST00000545852.1_Missense_Mutation_p.R239T|MRVI1_ENST00000534266.2_Missense_Mutation_p.R239T|MRVI1_ENST00000541483.1_Missense_Mutation_p.R348T|MRVI1_ENST00000421747.1_Missense_Mutation_p.R545T|MRVI1_ENST00000436272.1_Missense_Mutation_p.R527T|MRVI1_ENST00000527509.2_Missense_Mutation_p.R463T|MRVI1_ENST00000424001.1_Missense_Mutation_p.R239T	NM_001100163.2|NM_001206881.1	NP_001093633.1|NP_001193810.1	Q9Y6F6	MRVI1_HUMAN	murine retrovirus integration site 1 homolog	527					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		CTGGTTAATTCTAGATTCCAG	0.463000													20	37					0	0	1	0	0
NISCH	11188	broad.mit.edu	37	3	52521837	52521837	+	Missense_Mutation	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:52521837G>C	ENST00000345716.4	+	16	2463	c.2329G>C	c.(2329-2331)Gag>Cag	p.E777Q	NISCH_ENST00000479054.1_Missense_Mutation_p.E777Q	NM_007184.3	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin	777	Interaction with ITGA5 (By similarity).|Interaction with LIMK (By similarity).|Interaction with PAK1 (By similarity).				apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	33				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		CCTCATGCCGGAGCTGTGTCT	0.607000													15	21					0	0	1	0	0
CHST11	50515	broad.mit.edu	37	12	105151088	105151088	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:105151088T>C	ENST00000303694.5	+	3	1005	c.566T>C	c.(565-567)tTc>tCc	p.F189S	CHST11_ENST00000549260.1_Missense_Mutation_p.F184S	NM_018413.5	NP_060883.1	Q9NPF2	CHSTB_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 11	189					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			breast(2)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(1)	18						CGGGAGCCCTTCGAGAGGCTA	0.537000													12	26					0	0	1	0	0
NCOA5	57727	broad.mit.edu	37	20	44697186	44697186	+	Missense_Mutation	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr20:44697186C>T	ENST00000290231.6	-	4	621	c.457G>A	c.(457-459)Gat>Aat	p.D153N		NM_020967.2	NP_066018.1	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	153	Transcription repression.				regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|skin(2)|urinary_tract(1)	21		Myeloproliferative disorder(115;0.0122)				CCCCGTCCATCAAAGCTATCT	0.428000													21	70					0	0	1	0	0
PLK3	1263	broad.mit.edu	37	1	45269882	45269882	+	Missense_Mutation	SNP	T	T	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:45269882T>A	ENST00000372201.4	+	11	1545	c.1306T>A	c.(1306-1308)Tgt>Agt	p.C436S	PLK3_ENST00000465443.1_3'UTR	NM_004073.2	NP_004064.2	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	436						membrane	ATP binding|protein binding|protein serine/threonine kinase activity			endometrium(4)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(166;0.155)					GTCAGCCCTTTGTGCTCTGAG	0.557000													22	88					0	0	1	0	0
GLI3	2737	broad.mit.edu	37	7	42005347	42005347	+	Silent	SNP	G	G	A	rs116840766		TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr7:42005347G>A	ENST00000395925.3	-	15	3408	c.3324C>T	c.(3322-3324)taC>taT	p.Y1108Y	GLI3_ENST00000479210.1_5'UTR	NM_000168.5	NP_000159.3	P10071	GLI3_HUMAN	GLI family zinc finger 3	1108					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|breast(4)|central_nervous_system(2)|endometrium(12)|kidney(7)|large_intestine(25)|lung(49)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	112						AGTGCTGCTCGTACCCTGCTT	0.627000									Pallister-Hall syndrome;Greig Cephalopolysyndactyly				21	58					0	0	1	0	0
DHTKD1	55526	broad.mit.edu	37	10	12160822	12160822	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr10:12160822A>G	ENST00000263035.4	+	15	2539	c.2477A>G	c.(2476-2478)aAg>aGg	p.K826R		NM_018706.5	NP_061176	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain containing 1	826					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(1)	44		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			CTGGGGGCCAAGAAGCATGAC	0.463000													15	278					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14513675	14513675	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr18:14513675T>C	ENST00000358970.5	-	10	1518	c.1519A>G	c.(1519-1521)Aaa>Gaa	p.K507E		NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	507								p.K507E(2)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						GAATTCATTTTCTTTTCAGCC	0.284000													4	98					0	0	1	0	0
CTR9	9646	broad.mit.edu	37	11	10795636	10795636	+	Missense_Mutation	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr11:10795636G>C	ENST00000361367.2	+	22	3231	c.2805G>C	c.(2803-2805)aaG>aaC	p.K935N		NM_014633.3	NP_055448.1	Q6PD62	CTR9_HUMAN	CTR9, Paf1/RNA polymerase II complex component	935	Lys-rich.|Poly-Lys.				histone H2B ubiquitination|histone monoubiquitination	Cdc73/Paf1 complex|nuclear speck				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|pancreas(1)|stomach(1)	40				all cancers(16;1.64e-07)|Epithelial(150;2.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		CCaaaaagaagaagagaagaa	0.393000													15	21					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48621983	48621983	+	Missense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:48621983G>A	ENST00000328333.8	-	35	4161	c.4054C>T	c.(4054-4056)Ccc>Tcc	p.P1352S	COL7A1_ENST00000454817.1_Missense_Mutation_p.P1352S	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	1352	Interrupted collagenous region.|Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		ACTTGTCCGGGAGCCCCCTGT	0.587000													27	49					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179451514	179451514	+	Nonsense_Mutation	SNP	T	T	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:179451514T>A	ENST00000589042.1	-	308	64338	c.64114A>T	c.(64114-64116)Aaa>Taa	p.K21372*	TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000590743.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000359218.5_Nonsense_Mutation_p.K12432*|TTN_ENST00000460472.2_Nonsense_Mutation_p.K12307*|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000342992.6_Nonsense_Mutation_p.K18804*|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342175.6_Nonsense_Mutation_p.K12499*|TTN_ENST00000591111.1_Nonsense_Mutation_p.K19731*	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19731	Ig-like 113.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTTCTAATTTCCTTGGGGGA	0.408000													23	35					0	0	1	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28296419	28296419	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr21:28296419A>G	ENST00000284987.5	-	8	2867	c.2746T>C	c.(2746-2748)Tcc>Ccc	p.S916P	AP001601.2_ENST00000426771.1_RNA	NM_007038.3	NP_008969.2	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 5	916	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	72						GGCCTTTGGGAGAGAGGACAT	0.498000													19	25					0	0	1	0	0
CIAO1	9391	broad.mit.edu	37	2	96936943	96936943	+	Missense_Mutation	SNP	T	T	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:96936943T>G	ENST00000488633.1	+	7	1093	c.874T>G	c.(874-876)Ttc>Gtc	p.F292V		NM_004804.2	NP_004795.1	O76071	CIAO1_HUMAN	cytosolic iron-sulfur protein assembly 1	292					chromosome segregation|iron-sulfur cluster assembly|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter	MMXD complex	protein binding			endometrium(1)|lung(2)|stomach(1)|upper_aerodigestive_tract(1)	5						GCAGCCCACCTTCTCCCTGAC	0.607000													22	33					0	0	1	0	0
PUM2	23369	broad.mit.edu	37	2	20490541	20490541	+	Missense_Mutation	SNP	G	G	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:20490541G>T	ENST00000361078.2	-	9	1185	c.1163C>A	c.(1162-1164)gCt>gAt	p.A388D	PUM2_ENST00000403432.1_Missense_Mutation_p.A388D|PUM2_ENST00000338086.5_Missense_Mutation_p.A388D|PUM2_ENST00000319801.5_Missense_Mutation_p.A388D|PUM2_ENST00000536417.1_Missense_Mutation_p.A332D			Q8TB72	PUM2_HUMAN	pumilio RNA-binding family member 2	388	Ala-rich.|Gln-rich.				regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(7)|lung(13)|ovary(2)|prostate(4)|urinary_tract(3)	42	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACCTGCTCCAGCACGGAGAAC	0.403000													15	57					1.05317e-09	1.09377e-09	1	1	0
BAGE2	85319	broad.mit.edu	37	21	11039057	11039057	+	RNA	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr21:11039057C>G	ENST00000470054.1	-	0	1146									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTCCATCAATCCAGTAGAAAG	0.393000													36	323					0	0	1	0	0
TANC1	85461	broad.mit.edu	37	2	160086683	160086683	+	Silent	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:160086683A>G	ENST00000263635.6	+	27	4983	c.4746A>G	c.(4744-4746)ttA>ttG	p.L1582L	TANC1_ENST00000454300.1_Silent_p.L1476L	NM_001145909.1|NM_033394.2	NP_001139381.1|NP_203752.2	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	1582						cell junction|postsynaptic density|postsynaptic membrane	binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(25)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	77						CCCAGCATTTAGAGGGAACAG	0.557000													19	24					0	0	1	0	0
SLC36A2	153201	broad.mit.edu	37	5	150701773	150701773	+	Silent	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr5:150701773C>G	ENST00000335244.4	-	9	1143	c.1014G>C	c.(1012-1014)ctG>ctC	p.L338L	SLC36A2_ENST00000450886.1_Silent_p.L62L|SLC36A2_ENST00000521967.1_Silent_p.L338L	NM_181776.2	NP_861441.2	Q495M3	S36A2_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 2	338					cellular nitrogen compound metabolic process	cytoplasm|integral to membrane|plasma membrane	glycine transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(14)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAGACTGGTACAGCCTGCAAG	0.537000													17	13					0	0	1	0	0
COL4A3BP	10087	broad.mit.edu	37	5	74722266	74722266	+	Missense_Mutation	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr5:74722266C>T	ENST00000380494.5	-	5	1063	c.770G>A	c.(769-771)cGa>cAa	p.R257Q	COL4A3BP_ENST00000261415.7_Missense_Mutation_p.R129Q|COL4A3BP_ENST00000405807.4_Missense_Mutation_p.R129Q	NM_001130105.1	NP_001123577.1	Q9Y5P4	C43BP_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen) binding protein	129					ER to Golgi ceramide transport|immune response	cytosol|endoplasmic reticulum membrane|Golgi apparatus	ceramide binding|phosphatidylinositol-4-phosphate binding|protein binding|protein kinase activity			breast(1)|kidney(1)|large_intestine(5)|lung(4)|skin(3)|stomach(1)|urinary_tract(1)	16		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;1e-53)		TGAGCCATGTCGACGCAAGCT	0.378000													54	12					0	0	1	0	0
SLC15A2	6565	broad.mit.edu	37	3	121650524	121650524	+	Missense_Mutation	SNP	T	T	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:121650524T>A	ENST00000489711.1	+	19	2091	c.1703T>A	c.(1702-1704)tTt>tAt	p.F568Y	SLC15A2_ENST00000295605.2_Missense_Mutation_p.F537Y	NM_021082.3	NP_066568.3	Q16348	S15A2_HUMAN	solute carrier family 15 (oligopeptide transporter), member 2	568					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			NS(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(17)|skin(6)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	GATAAGAACTTTTCTCTGAAT	0.398000													11	49					0	0	1	0	0
OPN1LW	5956	broad.mit.edu	37	X	153420204	153420204	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chrX:153420204C>G	ENST00000369951.4	+	4	794	c.734C>G	c.(733-735)gCc>gGc	p.A245G	OPN1LW_ENST00000463296.1_Intron	NM_020061.4	NP_064445.2	P04000	OPSR_HUMAN	opsin 1 (cone pigments), long-wave-sensitive	245					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|skin(1)	15	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GTGTGGCTGGCCATCCGAGCG	0.572000													29	52					0	0	1	0	0
GUCY2F	2986	broad.mit.edu	37	X	108641917	108641917	+	Missense_Mutation	SNP	C	C	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chrX:108641917C>A	ENST00000218006.2	-	11	2427	c.2136G>T	c.(2134-2136)tgG>tgT	p.W712C		NM_001522.2	NP_001513.2	P51841	GUC2F_HUMAN	guanylate cyclase 2F, retinal	712	Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(6)|large_intestine(14)|lung(33)|prostate(3)|skin(1)	67						CAGGGGCCGTCCACAGCAGCT	0.463000													16	18					3.52763e-06	3.61142e-06	1	1	0
NEDD8	4738	broad.mit.edu	37	14	24687622	24687622	+	Missense_Mutation	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr14:24687622C>T	ENST00000250495.5	-	2	220	c.34G>A	c.(34-36)Gag>Aag	p.E12K	NEDD8_ENST00000524927.1_Missense_Mutation_p.E12K|NEDD8-MDP1_ENST00000604306.1_5'UTR|NEDD8-MDP1_ENST00000534348.1_Missense_Mutation_p.E12K	NM_006156.2	NP_006147.1			neural precursor cell expressed, developmentally down-regulated 8											breast(1)|central_nervous_system(1)|large_intestine(1)|lung(2)	5				GBM - Glioblastoma multiforme(265;0.0186)		ATCTCAATCTCCTTTCCGGTC	0.418000													12	14					0	0	1	0	0
BCAS2	10286	broad.mit.edu	37	1	115110849	115110849	+	Missense_Mutation	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:115110849C>T	ENST00000369541.3	-	7	627	c.580G>A	c.(580-582)Gag>Aag	p.E194K	BCAS2_ENST00000485021.1_5'UTR	NM_005872.2	NP_005863.1	O75934	SPF27_HUMAN	breast carcinoma amplified sequence 2	194					mRNA processing|RNA splicing, via transesterification reactions	nucleolus|spliceosomal complex	protein binding			biliary_tract(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(4)	13	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CGTTCAATCTCATAATTCTTA	0.343000													20	80					0	0	1	0	0
LLGL1	3996	broad.mit.edu	37	17	18141407	18141407	+	Missense_Mutation	SNP	T	T	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr17:18141407T>A	ENST00000316843.4	+	15	2027	c.1931T>A	c.(1930-1932)cTg>cAg	p.L644Q		NM_004140.3	NP_004131	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1 (Drosophila)	644					cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_neural(463;0.228)					AATGACTCCCTGGCCATGGAG	0.617000													8	12					0	0	1	0	0
PNPLA1	285848	broad.mit.edu	37	6	36270150	36270150	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr6:36270150T>C	ENST00000394571.2	+	6	1288	c.1288T>C	c.(1288-1290)Tca>Cca	p.S430P	PNPLA1_ENST00000388715.3_Missense_Mutation_p.S335P|PNPLA1_ENST00000312917.5_Missense_Mutation_p.S344P	NM_001145717.1	NP_001139189.2	Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	430	Pro-rich.				lipid catabolic process		hydrolase activity			breast(1)|kidney(1)|large_intestine(4)|lung(9)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	22						CCTGGGGCCTTCAACTGTGGG	0.587000											OREG0017382	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	80					0	0	1	0	0
OR8J3	81168	broad.mit.edu	37	11	55905105	55905105	+	Silent	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr11:55905105G>A	ENST00000301529.1	-	1	89	c.90C>T	c.(88-90)gtC>gtT	p.V30V		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	30					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					GCACTAGGAAGACCAGGAAGA	0.498000													31	61					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9015691	9015691	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:9015691T>C	ENST00000397910.4	-	29	38335	c.38132A>G	c.(38131-38133)aAg>aGg	p.K12711R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12713	SEA 5.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTCCTCGTACTTCAGGTTGGT	0.512000													30	68					0	0	1	0	0
TMC4	147798	broad.mit.edu	37	19	54673379	54673379	+	Missense_Mutation	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:54673379C>T	ENST00000376591.4	-	3	462	c.331G>A	c.(331-333)Gac>Aac	p.D111N	TMC4_ENST00000301187.4_Missense_Mutation_p.D105N|TMC4_ENST00000476013.2_5'UTR	NM_001145303.1|NM_144686.2	NP_001138775|NP_653287.2	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4	111						integral to membrane				breast(2)|endometrium(7)|large_intestine(4)|lung(6)|pancreas(1)|skin(1)|urinary_tract(1)	22	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					ACCACCTGGTCCCTGCTGGCA	0.552000													9	73					0	0	1	0	0
STEAP4	79689	broad.mit.edu	37	7	87908751	87908751	+	Silent	SNP	T	T	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr7:87908751T>G	ENST00000380079.4	-	5	1443	c.1342A>C	c.(1342-1344)Agg>Cgg	p.R448R	AC003991.3_ENST00000595121.1_RNA|STEAP4_ENST00000301959.5_Silent_p.R272R|AC003991.3_ENST00000434733.1_RNA|AC003991.3_ENST00000447758.1_RNA|AC003991.3_ENST00000600908.1_RNA	NM_001205315.1|NM_024636.3	NP_001192244.1|NP_078912.2	Q687X5	STEA4_HUMAN	STEAP family member 4	448					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(3)	15	Esophageal squamous(14;0.00802)					TGGCGGATCCTTGTAAGGGTG	0.413000													16	26					0	0	1	0	0
RNF139	11236	broad.mit.edu	37	8	125499112	125499112	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr8:125499112T>C	ENST00000303545.3	+	2	1594	c.1222T>C	c.(1222-1224)Tat>Cat	p.Y408H		NM_007218.3	NP_009149.2	Q8WU17	RN139_HUMAN	ring finger protein 139	408					negative regulation of cell proliferation|regulation of protein ubiquitination	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|liver(1)|lung(4)|prostate(1)|skin(1)	20	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			CTTACTCAGTTATGTTCTTTG	0.378000													7	274					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118512702	118512702	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:118512702T>C	ENST00000336338.5	-	46	6429	c.6364A>G	c.(6364-6366)Aaa>Gaa	p.K2122E		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	2122						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TAAGTCACTTTCAGTCCTGTG	0.418000													4	67					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6191772	6191772	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:6191772C>G	ENST00000262450.3	-	21	3280	c.3181G>C	c.(3181-3183)Gag>Cag	p.E1061Q	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1061	Helicase C-terminal.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CCTTCGTACTCCAGGAAGTCC	0.612000													8	30					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150171306	150171306	+	Nonsense_Mutation	SNP	A	A	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr7:150171306A>T	ENST00000307271.3	+	4	1463	c.889A>T	c.(889-891)Aaa>Taa	p.K297*		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	297						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		GAGAAAAAAGAAAGTTTCGAT	0.468000													17	35					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882688	228882688	+	Missense_Mutation	SNP	G	G	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:228882688G>T	ENST00000392056.3	-	7	2928	c.2882C>A	c.(2881-2883)gCa>gAa	p.A961E	SPHKAP_ENST00000344657.5_Missense_Mutation_p.A961E	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	961						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TCTTTTCCATGCACAAAACCA	0.512000													17	57					3.45872e-05	3.51582e-05	1	1	0
ZNF733P	643955	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													3	36					0	0	1	0	0
TTC18	118491	broad.mit.edu	37	10	75051135	75051135	+	Silent	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr10:75051135C>T	ENST00000401621.2	-	20	2418	c.2298G>A	c.(2296-2298)caG>caA	p.Q766Q	TTC18_ENST00000355577.3_Silent_p.Q235Q|TTC18_ENST00000493787.1_5'UTR|TTC18_ENST00000340329.3_Intron|TTC18_ENST00000394865.1_Silent_p.Q766Q|TTC18_ENST00000310715.3_Silent_p.Q766Q			Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	766							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	Prostate(51;0.0119)					GTGCCTGAAGCTGTTTGGAGG	0.408000													25	55					0	0	1	0	0
KDELC1	79070	broad.mit.edu	37	13	103445705	103445705	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr13:103445705A>G	ENST00000376004.4	-	4	994	c.658T>C	c.(658-660)Tct>Cct	p.S220P	KDELC1_ENST00000460338.1_5'UTR	NM_024089.2	NP_076994.2	Q6UW63	KDEL1_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 1	220						endoplasmic reticulum lumen				central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(1)	19	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					CTAGTCAAAGAAAGTAGTATG	0.269000													28	92					0	0	1	0	0
TMEM190	147744	broad.mit.edu	37	19	55889456	55889456	+	Missense_Mutation	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:55889456C>T	ENST00000291934.3	+	5	437	c.419C>T	c.(418-420)tCc>tTc	p.S140F	CTD-2105E13.15_ENST00000595064.1_RNA	NM_139172.1	NP_631911.1	Q8WZ59	TM190_HUMAN	transmembrane protein 190	140						integral to membrane				large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	5	Breast(117;0.191)		BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		AAGACGCCGTCCACGGGCAGC	0.657000													14	36					0	0	1	0	0
SH3GLB1	51100	broad.mit.edu	37	1	87200814	87200814	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:87200814A>G	ENST00000370558.4	+	7	1037	c.713A>G	c.(712-714)tAt>tGt	p.Y238C	SH3GLB1_ENST00000535010.1_Missense_Mutation_p.Y138C|SH3GLB1_ENST00000482504.1_Missense_Mutation_p.Y259C	NM_001206651.1|NM_001206653.1|NM_016009.4	NP_001193580.1|NP_001193582.1|NP_057093.1	Q9Y371	SHLB1_HUMAN	SH3-domain GRB2-like endophilin B1	238	BAR.				anti-apoptosis|filopodium assembly|signal transduction	Golgi membrane|mitochondrial outer membrane	cytoskeletal adaptor activity|protein homodimerization activity|SH3 domain binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|stomach(1)	11		Lung NSC(277;0.209)		all cancers(265;0.0136)|Epithelial(280;0.0414)		ATGACTTACTATGCACAGTGT	0.373000													31	110					0	0	1	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64595050	64595050	+	Missense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr11:64595050G>A	ENST00000342711.5	-	32	4098	c.4099C>T	c.(4099-4101)Ctc>Ttc	p.L1367F		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	1367					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						GTGCCGTAGAGGAACAGGGAG	0.682000													7	5					0	0	1	0	0
RAD54B	25788	broad.mit.edu	37	8	95392458	95392458	+	Missense_Mutation	SNP	T	T	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr8:95392458T>A	ENST00000336148.5	-	12	2286	c.2162A>T	c.(2161-2163)aAa>aTa	p.K721I		NM_012415.3	NP_036547.1	O95073	FSBP_HUMAN	RAD54 homolog B (S. cerevisiae)	0					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(10)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			ACCACCAGCTTTTGAACTTAA	0.373000								Direct reversal of damage;Homologous recombination					12	33					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33156831	33156831	+	Silent	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr6:33156831G>A	ENST00000341947.2	-	3	594	c.367C>T	c.(367-369)Ctg>Ttg	p.L123L	COL11A2_ENST00000374712.1_Silent_p.L123L|COL11A2_ENST00000374714.1_Silent_p.L123L|COL11A2_ENST00000395197.1_Silent_p.L123L|COL11A2_ENST00000374713.1_Silent_p.L123L|COL11A2_ENST00000357486.1_Silent_p.L123L|COL11A2_ENST00000395194.1_Silent_p.L123L|COL11A2_ENST00000361917.1_Silent_p.L123L|COL11A2_ENST00000374708.4_Silent_p.L123L	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	123	TSP N-terminal.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						TCTTCATACAGGAAGCGGACA	0.622000													23	78					0	0	1	0	0
SLK	9748	broad.mit.edu	37	10	105750520	105750520	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr10:105750520A>G	ENST00000369755.3	+	2	783	c.238A>G	c.(238-240)Att>Gtt	p.I80V	SLK_ENST00000335753.4_Missense_Mutation_p.I80V	NM_014720.2	NP_055535.2	Q9H2G2	SLK_HUMAN	STE20-like kinase	80	Protein kinase.				apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			kidney(1)|lung(1)|ovary(2)|skin(2)|stomach(2)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		CATGGTAGAGATTGACATATT	0.353000													3	60					0	0	1	0	0
STAG1	10274	broad.mit.edu	37	3	136139968	136139968	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:136139968A>G	ENST00000383202.2	-	20	2331	c.2075T>C	c.(2074-2076)cTt>cCt	p.L692P	STAG1_ENST00000536929.1_Missense_Mutation_p.L276P|STAG1_ENST00000434713.2_Missense_Mutation_p.L466P|STAG1_ENST00000236698.5_Missense_Mutation_p.L692P	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	692					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						TAATGTAGAAAGAACATTGTA	0.338000													27	100					0	0	1	0	0
HIPK3	10114	broad.mit.edu	37	11	33308034	33308034	+	Missense_Mutation	SNP	A	A	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr11:33308034A>C	ENST00000303296.4	+	2	379	c.74A>C	c.(73-75)aAa>aCa	p.K25T	HIPK3_ENST00000456517.1_Missense_Mutation_p.K25T|HIPK3_ENST00000525975.1_Missense_Mutation_p.K25T|HIPK3_ENST00000379016.3_Missense_Mutation_p.K25T	NM_005734.3	NP_005725.3	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3	25					anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			endometrium(3)|kidney(3)|large_intestine(9)|liver(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	39						AGTGTGAAGAAACTCAAAGTA	0.393000													5	33					0	0	1	0	0
DENND3	22898	broad.mit.edu	37	8	142178608	142178608	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr8:142178608C>G	ENST00000519811.1	+	13	2329	c.2259C>G	c.(2257-2259)ttC>ttG	p.F753L	DENND3_ENST00000424248.1_Missense_Mutation_p.F621L|DENND3_ENST00000262585.2_Missense_Mutation_p.F673L			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	673										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			ACCGGCTGTTCGAGGCCTTGA	0.557000													11	49					0	0	1	0	0
ANGPTL4	51129	broad.mit.edu	37	19	8431137	8431137	+	Nonsense_Mutation	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:8431137C>T	ENST00000301455.2	+	3	652	c.481C>T	c.(481-483)Cga>Tga	p.R161*	ANGPTL4_ENST00000393962.2_Nonsense_Mutation_p.R161*|ANGPTL4_ENST00000541807.1_5'UTR	NM_139314.1	NP_647475.1	Q9BY76	ANGL4_HUMAN	angiopoietin-like 4	161					angiogenesis|cell differentiation|cellular lipid metabolic process|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|positive regulation of angiogenesis|response to hypoxia|signal transduction|triglyceride homeostasis	extracellular space|proteinaceous extracellular matrix	enzyme inhibitor activity|receptor binding			large_intestine(1)|lung(1)|ovary(2)|skin(2)	6						CAAGCCTGCCCGAAGAAAGAG	0.652000													10	23					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	150876567	150876567	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:150876567T>C	ENST00000474524.1	+	6	856	c.818T>C	c.(817-819)tTg>tCg	p.L273S	MED12L_ENST00000309237.4_Missense_Mutation_p.L273S|MED12L_ENST00000422248.2_Missense_Mutation_p.L273S|MED12L_ENST00000273432.4_Missense_Mutation_p.L273S	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	273					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CTTAAACTCTTGCTACCACTA	0.383000													6	26					0	0	1	0	0
TDRD7	23424	broad.mit.edu	37	9	100222922	100222922	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr9:100222922A>G	ENST00000355295.4	+	7	1613	c.1318A>G	c.(1318-1320)Agc>Ggc	p.S440G	TDRD7_ENST00000422139.2_Missense_Mutation_p.S366G	NM_014290.2	NP_055105.2	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	440	Lotus/OST-HTH 3.				lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Acute lymphoblastic leukemia(62;0.158)				GGTAGAAGAAAGCATTGCTGA	0.413000													13	101					0	0	1	0	0
LEPROT	54741	broad.mit.edu	37	1	65895677	65895677	+	Silent	SNP	T	T	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:65895677T>A	ENST00000371065.4	+	3	363	c.225T>A	c.(223-225)acT>acA	p.T75T	LEPR_ENST00000344610.8_Intron|LEPR_ENST00000349533.6_Intron|LEPR_ENST00000371059.3_Intron|LEPROT_ENST00000484243.1_3'UTR|LEPR_ENST00000371060.3_Intron|LEPR_ENST00000406510.3_Intron	NM_001198681.1|NM_017526.4	NP_001185610.1|NP_059996.1	O15243	OBRG_HUMAN	leptin receptor overlapping transcript	75						endosome membrane|Golgi membrane|integral to plasma membrane				kidney(1)|large_intestine(1)|lung(5)	7				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		TCTTCACTACTGGAATTGTTG	0.448000													61	197					0	0	1	0	0
KIAA2026	158358	broad.mit.edu	37	9	5921972	5921972	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr9:5921972T>C	ENST00000399933.3	-	8	4023	c.4024A>G	c.(4024-4026)Aca>Gca	p.T1342A	KIAA2026_ENST00000381461.2_Missense_Mutation_p.T1312A	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	1342	Ser-rich.									breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		AGACTAGATGTAGTAGTTGTT	0.428000													53	73					0	0	1	0	0
COQ2	27235	broad.mit.edu	37	4	84205926	84205926	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr4:84205926T>C	ENST00000311469.4	-	1	141	c.142A>G	c.(142-144)Acc>Gcc	p.T48A	COQ2_ENST00000439031.2_Missense_Mutation_p.T11A	NM_015697.7	NP_056512.5	Q96H96	COQ2_HUMAN	coenzyme Q2 4-hydroxybenzoate polyprenyltransferase	0					glycerol metabolic process|isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrial membrane	4-hydroxybenzoate decaprenyltransferase activity|4-hydroxybenzoate nonaprenyltransferase activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|ovary(1)|skin(1)|stomach(1)	8		Hepatocellular(203;0.114)				ATGGCGCTGGTGAGGCCGGGA	0.736000													5	2					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56321312	56321312	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:56321312T>C	ENST00000443188.1	-	5	1374	c.664A>G	c.(664-666)Aag>Gag	p.K222E	NLRP11_ENST00000592953.1_Missense_Mutation_p.K123E|NLRP11_ENST00000589093.1_Missense_Mutation_p.K222E|NLRP11_ENST00000360133.3_Missense_Mutation_p.K222E|NLRP11_ENST00000589824.2_Missense_Mutation_p.K222E	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	222	NACHT.						ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		AGGAGTTTCTTGGGATCAGAC	0.473000													15	53					0	0	1	0	0
AGGF1	55109	broad.mit.edu	37	5	76335496	76335496	+	Silent	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr5:76335496G>A	ENST00000312916.7	+	5	1204	c.822G>A	c.(820-822)ttG>ttA	p.L274L		NM_018046.4	NP_060516.2	Q8N302	AGGF1_HUMAN	angiogenic factor with G patch and FHA domains 1	274					angiogenesis|cell adhesion|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|RNA processing|vasculogenesis	extracellular region|perinuclear region of cytoplasm	eukaryotic cell surface binding|nucleic acid binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|liver(2)|lung(4)|ovary(1)|prostate(1)|skin(2)	20		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;4.51e-51)|Epithelial(54;2.2e-45)|all cancers(79;6.68e-41)		ATAAAAAATTGAAGAAGAAAA	0.308000													11	41					0	0	1	0	0
CDIPT	10423	broad.mit.edu	37	16	29873943	29873943	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr16:29873943C>G	ENST00000219789.6	-	2	1020	c.142G>C	c.(142-144)Gct>Cct	p.A48P	CDIPT_ENST00000566113.1_Intron|CDIPT_ENST00000570016.1_Missense_Mutation_p.A48P|CDIPT_ENST00000569956.1_Missense_Mutation_p.A48P|CDIPT_ENST00000563415.1_Missense_Mutation_p.A48P	NM_006319.3	NP_006310.1	O14735	CDIPT_HUMAN	CDP-diacylglycerol--inositol 3-phosphatidyltransferase	48						endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity|phosphatidylinositol transporter activity			endometrium(1)|lung(3)	4						CCATCGAAAGCGTCCAGCAGG	0.587000													3	3					0	0	1	0	0
SCG2	7857	broad.mit.edu	37	2	224463616	224463616	+	Missense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:224463616G>A	ENST00000305409.2	-	2	617	c.385C>T	c.(385-387)Cca>Tca	p.P129S		NM_003469.4	NP_003460.2	P13521	SCG2_HUMAN	secretogranin II	129					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			NS(1)|breast(1)|endometrium(1)|kidney(6)|large_intestine(10)|liver(1)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	44		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		TTTTCTTTTGGTGCAGACTGA	0.428000													39	83					0	0	1	0	0
PARD3	56288	broad.mit.edu	37	10	34671569	34671569	+	Missense_Mutation	SNP	G	G	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr10:34671569G>T	ENST00000374789.3	-	9	1623	c.1298C>A	c.(1297-1299)tCc>tAc	p.S433Y	PARD3_ENST00000374776.1_Missense_Mutation_p.S433Y|PARD3_ENST00000374773.1_Missense_Mutation_p.S433Y|PARD3_ENST00000346874.4_Missense_Mutation_p.S433Y|PARD3_ENST00000545260.1_Missense_Mutation_p.S389Y|PARD3_ENST00000545693.1_Missense_Mutation_p.S433Y|PARD3_ENST00000350537.4_Missense_Mutation_p.S433Y|PARD3_ENST00000374790.3_Missense_Mutation_p.S389Y|PARD3_ENST00000340077.5_Missense_Mutation_p.S433Y|PARD3_ENST00000374788.3_Missense_Mutation_p.S433Y|PARD3_ENST00000374794.3_Missense_Mutation_p.S389Y|PARD3_ENST00000544292.1_Missense_Mutation_p.S163Y	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	433					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				GGCTGGAGCGGATGGTGGTTT	0.502000													41	53					3.38236e-24	3.64449e-24	1	1	0
MED13L	23389	broad.mit.edu	37	12	116450611	116450611	+	Missense_Mutation	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:116450611G>C	ENST00000281928.3	-	9	1477	c.1271C>G	c.(1270-1272)tCt>tGt	p.S424C		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	424					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		CCTGGAACAAGAACAGCTGAC	0.438000													36	112					0	0	1	0	0
GPATCH8	23131	broad.mit.edu	37	17	42477235	42477235	+	Missense_Mutation	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr17:42477235C>T	ENST00000434000.1	-	9	2258	c.1976G>A	c.(1975-1977)gGg>gAg	p.G659E	GPATCH8_ENST00000591680.1_Missense_Mutation_p.G737E			Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	737						intracellular	nucleic acid binding|zinc ion binding			breast(4)|endometrium(7)|kidney(6)|large_intestine(4)|liver(2)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		ACTGCCACTCCCAGGGGGTTC	0.537000													28	69					0	0	1	0	0
BDP1	55814	broad.mit.edu	37	5	70805493	70805493	+	Missense_Mutation	SNP	G	G	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr5:70805493G>T	ENST00000358731.4	+	17	2837	c.2574G>T	c.(2572-2574)aaG>aaT	p.K858N	BDP1_ENST00000380675.2_5'UTR	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	858	9 X 55 AA repeats of G-R-R-X-I-S-P-X-E-N- G-X-E-E-V-K-P-X-X-E-M-E-T-D-L-K-X-T-G-R- E-X-X-X-R-E-K-T-X-E-X-X-D-A-X-E-E-I-D-X- D-L-E-E-T.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		CCTCACCAAAGGAGATGGTAC	0.418000													22	40					1.9806e-07	2.03247e-07	1	1	0
AMOT	154796	broad.mit.edu	37	X	112058693	112058693	+	Missense_Mutation	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chrX:112058693C>T	ENST00000371959.3	-	2	1284	c.1285G>A	c.(1285-1287)Gcc>Acc	p.A429T	AMOT_ENST00000524145.1_Missense_Mutation_p.A429T|AMOT_ENST00000371962.1_Missense_Mutation_p.A197T|AMOT_ENST00000304758.1_Missense_Mutation_p.A20T|AMOT_ENST00000371958.1_Missense_Mutation_p.A197T	NM_001113490.1	NP_001106962.1	Q4VCS5	AMOT_HUMAN	angiomotin	429					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction	angiostatin binding|protein binding|receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	43						GAAACAATGGCAAAAGGGTCT	0.547000													48	67					0	0	1	0	0
SHH	6469	broad.mit.edu	37	7	155596378	155596378	+	Missense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr7:155596378G>A	ENST00000297261.2	-	3	755	c.605C>T	c.(604-606)tCg>tTg	p.S202L		NM_000193.2	NP_000184.1	Q15465	SHH_HUMAN	sonic hedgehog	202					androgen metabolic process|axon guidance|branching involved in ureteric bud morphogenesis|CD4-positive or CD8-positive, alpha-beta T cell lineage commitment|embryonic digit morphogenesis|hindbrain development|intein-mediated protein splicing|lymphoid progenitor cell differentiation|metanephric mesenchymal cell proliferation involved in metanephros development|midbrain development|negative regulation of cell migration|negative regulation of kidney smooth muscle cell differentiation|negative regulation of ureter smooth muscle cell differentiation|negative thymic T cell selection|neural crest cell migration|neuroblast proliferation|patterning of blood vessels|positive regulation of alpha-beta T cell differentiation|positive regulation of immature T cell proliferation in thymus|positive regulation of kidney smooth muscle cell differentiation|positive regulation of mesenchymal cell proliferation involved in ureter development|positive regulation of T cell differentiation in thymus|positive regulation of ureter smooth muscle cell differentiation|positive thymic T cell selection|proteolysis|sclerotome development|stem cell development|thymus development|vasculogenesis|ventral midline development	cell surface|extracellular space|membrane raft|plasma membrane	calcium ion binding|laminin-1 binding|peptidase activity|signal transducer activity|zinc ion binding			central_nervous_system(3)|kidney(1)|large_intestine(1)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	14	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00882)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CACCGTGGCCGAGCCCGGGAA	0.682000													10	9					0	0	1	0	0
CEP350	9857	broad.mit.edu	37	1	180080183	180080183	+	Missense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:180080183G>A	ENST00000367607.3	+	38	9659	c.9241G>A	c.(9241-9243)Gag>Aag	p.E3081K	CEP350_ENST00000490141.1_3'UTR	NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	3081						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						TGATGAGGATGAGTTGTGTGT	0.433000													9	23					0	0	1	0	0
PLEKHA8P1	51054	broad.mit.edu	37	12	45567171	45567171	+	RNA	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:45567171C>G	ENST00000256692.5	-	0	1514					NR_037144.1															breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(10)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						CATGGTGTTGCCGCAATGTTT	0.443000													45	24					0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23545076	23545076	+	Missense_Mutation	SNP	A	A	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:23545076A>C	ENST00000300619.7	-	4	910	c.705T>G	c.(703-705)gaT>gaG	p.D235E	ZNF91_ENST00000397082.2_Missense_Mutation_p.D203E|ZNF91_ENST00000599743.1_Intron	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	235						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TGTAGGGTTTATCTTCAGTAT	0.343000													14	63					0	0	1	0	0
IRS1	3667	broad.mit.edu	37	2	227660100	227660100	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:227660100A>G	ENST00000305123.5	-	1	4375	c.3355T>C	c.(3355-3357)Ttt>Ctt	p.F1119L		NM_005544.2	NP_005535.1	P35568	IRS1_HUMAN	insulin receptor substrate 1						fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(10)|lung(33)|ovary(6)|pancreas(1)|prostate(1)|urinary_tract(2)	69		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		CCCGCTCCAAAGGGCACTGTG	0.622000													22	31					0	0	1	0	0
ZNF709	163051	broad.mit.edu	37	19	12576368	12576368	+	Missense_Mutation	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:12576368G>C	ENST00000397732.3	-	4	539	c.368C>G	c.(367-369)tCt>tGt	p.S123C	ZNF709_ENST00000428311.1_Missense_Mutation_p.S123C|CTD-3105H18.18_ENST00000598753.1_Intron	NM_152601.3	NP_689814.1	Q8N972	ZN709_HUMAN	zinc finger protein 709	123					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(3)|upper_aerodigestive_tract(3)	6						TTCAGTATGAGATCTCATGTG	0.328000													25	40					0	0	1	0	0
ASB14	142686	broad.mit.edu	37	3	57312500	57312500	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:57312500C>G	ENST00000487349.1	-	8	1456	c.1336G>C	c.(1336-1338)Gac>Cac	p.D446H	ASB14_ENST00000389601.3_Missense_Mutation_p.D446H	NM_001142733.2|NM_130387.5	NP_001136205.2|NP_569058.1	A6NK59	ASB14_HUMAN	ankyrin repeat and SOCS box containing 14	446					intracellular signal transduction					central_nervous_system(1)|large_intestine(1)|lung(1)|skin(2)	5				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		CGCTCTGTGTCATACCCATAG	0.423000													32	57					0	0	1	0	0
UAP1L1	91373	broad.mit.edu	37	9	139975312	139975312	+	Silent	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr9:139975312C>G	ENST00000409858.3	+	7	1382	c.1350C>G	c.(1348-1350)ctC>ctG	p.L450L	UAP1L1_ENST00000360271.3_Silent_p.L327L	NM_207309.2	NP_997192.2	Q3KQV9	UAP1L_HUMAN	UDP-N-acteylglucosamine pyrophosphorylase 1-like 1	450							nucleotidyltransferase activity			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	8	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		GGGCCTGGCTCCCAGAGCTGC	0.697000													11	14					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44019282	44019282	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:44019282A>G	ENST00000359947.4	+	4	551	c.211A>G	c.(211-213)Aag>Gag	p.K71E	PTPRF_ENST00000372413.3_Missense_Mutation_p.K71E|PTPRF_ENST00000438120.1_Missense_Mutation_p.K71E|PTPRF_ENST00000372414.3_Missense_Mutation_p.K71E	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	71	Ig-like C2-type 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GAAGAAGGGGAAGAAAGTCAG	0.607000													9	159					0	0	1	0	0
LRRC37A6P	387646	broad.mit.edu	37	10	27537958	27537958	+	RNA	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr10:27537958T>C	ENST00000574842.1	+	0	255				LRRC37A6P_ENST00000284414.4_RNA																							GTTAAAGCCTTATTTTGGGCG	0.493000													46	177					0	0	1	0	0
PRCC	5546	broad.mit.edu	37	1	156756405	156756405	+	Silent	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:156756405C>G	ENST00000271526.4	+	3	794	c.522C>G	c.(520-522)tcC>tcG	p.S174S	PRCC_ENST00000353233.3_Silent_p.S174S|PRCC_ENST00000491853.1_3'UTR	NM_005973.4	NP_005964.3	Q92733	PRCC_HUMAN	papillary renal cell carcinoma (translocation-associated)	174					cell cycle|mitotic cell cycle checkpoint	nucleus	protein binding		PRCC/TFE3(25)	breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(1)|liver(1)|lung(5)|upper_aerodigestive_tract(1)	15	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					ACCAGGGATCCAGTGAGGGGA	0.478000			T	TFE3	papillary renal								25	13					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101433738	101433738	+	Silent	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:101433738T>C	ENST00000392979.3	+	10	1159	c.798T>C	c.(796-798)agT>agC	p.S266S	ANO4_ENST00000299222.9_5'UTR|ANO4_ENST00000392977.3_Silent_p.S301S	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	301						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						CCCAGGGAAGTTATAGAAGTA	0.453000										HNSCC(74;0.22)			24	77					0	0	1	0	0
IGKV1D-13	28902	broad.mit.edu	37	2	90193213	90193213	+	RNA	SNP	C	C	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:90193213C>A	ENST00000390275.2	+	0	320																											ACTTGCCGGGCAAGTCAGGGC	0.527000													36	167					1.34479e-40	1.46364e-40	1	1	0
HEG1	57493	broad.mit.edu	37	3	124720767	124720767	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:124720767T>C	ENST00000311127.4	-	11	3513	c.3446A>G	c.(3445-3447)aAa>aGa	p.K1149R		NM_020733.1	NP_065784.1	Q9ULI3	HEG1_HUMAN	heart development protein with EGF-like domains 1	1149						extracellular region|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(24)|ovary(2)|urinary_tract(4)	47						GTTGACACATTTCTGCATCCT	0.532000													6	17					0	0	1	0	0
DHX38	9785	broad.mit.edu	37	16	72130344	72130344	+	Silent	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr16:72130344C>T	ENST00000268482.3	+	2	797	c.288C>T	c.(286-288)ggC>ggT	p.G96G	DHX38_ENST00000536867.1_Silent_p.G96G	NM_014003.3	NP_054722.2	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	96					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(5)|kidney(1)|large_intestine(16)|lung(15)|pancreas(1)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	48		Ovarian(137;0.125)				AGGAAGAGGGCGGTGACCAGG	0.527000													4	11					0	0	1	0	0
MYOF	26509	broad.mit.edu	37	10	95159171	95159171	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr10:95159171T>C	ENST00000371501.4	-	13	1321	c.1199A>G	c.(1198-1200)gAa>gGa	p.E400G	MYOF_ENST00000371489.1_Missense_Mutation_p.E400G|MYOF_ENST00000359263.4_Missense_Mutation_p.E400G|MYOF_ENST00000358334.5_Missense_Mutation_p.E400G|MYOF_ENST00000371502.4_Missense_Mutation_p.E400G			Q9NZM1	MYOF_HUMAN	myoferlin	400	C2 3.				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						AAAGGAAACTTCTACAAAAGG	0.363000													6	27					0	0	1	0	0
AP1B1	162	broad.mit.edu	37	22	29734998	29734998	+	Nonsense_Mutation	SNP	G	G	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr22:29734998G>T	ENST00000357586.2	-	16	2330	c.2144C>A	c.(2143-2145)tCa>tAa	p.S715*	AP1B1_ENST00000472057.1_5'UTR|AP1B1_ENST00000317368.7_Nonsense_Mutation_p.S708*|AP1B1_ENST00000356015.2_Nonsense_Mutation_p.S708*|AP1B1_ENST00000415447.1_Nonsense_Mutation_p.S708*|AP1B1_ENST00000432560.2_Nonsense_Mutation_p.S708*|AP1B1_ENST00000405198.1_Nonsense_Mutation_p.S715*|AP1B1_ENST00000402502.1_Nonsense_Mutation_p.S708*	NM_001127.3	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1, beta 1 subunit	715	Pro-rich (stalk region).				endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						GGCCACATATGATCCTGACAG	0.562000													48	82					6.08268e-21	6.5053e-21	1	1	0
FAM83G	644815	broad.mit.edu	37	17	18907196	18907196	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr17:18907196C>G	ENST00000388995.6	-	2	382	c.159G>C	c.(157-159)gaG>gaC	p.E53D	SLC5A10_ENST00000317977.6_Intron|SLC5A10_ENST00000395642.1_Intron|SLC5A10_ENST00000395645.3_Intron|SLC5A10_ENST00000395647.2_Intron|SLC5A10_ENST00000395643.2_Intron|FAM83G_ENST00000345041.4_Missense_Mutation_p.E53D|FAM83G_ENST00000585154.2_Missense_Mutation_p.E53D|SLC5A10_ENST00000417251.2_Intron			A6ND36	FA83G_HUMAN	family with sequence similarity 83, member G	53										central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(7)|ovary(2)|prostate(3)|stomach(1)	22						CTCGGATGTTCTCCCGCTTGA	0.667000													15	33					0	0	1	0	0
ZNF711	7552	broad.mit.edu	37	X	84519436	84519436	+	Splice_Site	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chrX:84519436G>C	ENST00000360700.4	+	5	1664	c.778G>C	c.(778-780)Ggt>Cgt	p.G260R	ZNF711_ENST00000373165.3_Splice_Site_p.G260R|ZNF711_ENST00000276123.3_Splice_Site_p.G260R|ZNF711_ENST00000395402.1_Splice_Site_p.G238R|ZNF711_ENST00000542798.1_Splice_Site_p.G56R			Q9Y462	ZN711_HUMAN	zinc finger protein 711	260					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						TGTTGAAATAGGTACAAACAC	0.313000													9	16					0	0	1	0	0
GDAP1	54332	broad.mit.edu	37	8	75275250	75275250	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr8:75275250T>C	ENST00000220822.7	+	5	736	c.656T>C	c.(655-657)gTt>gCt	p.V219A	GDAP1_ENST00000521096.1_3'UTR|GDAP1_ENST00000434412.2_Missense_Mutation_p.V151A	NM_001040875.2|NM_018972.2	NP_001035808.1|NP_061845.2	Q8TB36	GDAP1_HUMAN	ganglioside induced differentiation associated protein 1	219	GST C-terminal.					cytoplasm				endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	10	Breast(64;0.00769)	Myeloproliferative disorder(644;0.0122)	BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.104)|all cancers(69;0.234)			TTGGATCAGGTTGAAACTGAA	0.333000													66	89					0	0	1	0	0
CLEC4F	165530	broad.mit.edu	37	2	71036485	71036485	+	Missense_Mutation	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:71036485C>T	ENST00000272367.2	-	7	1764	c.1688G>A	c.(1687-1689)aGa>aAa	p.R563K	CLEC4F_ENST00000426626.1_Intron	NM_001258027.1|NM_173535.2	NP_001244956.1|NP_775806.2	Q8N1N0	CLC4F_HUMAN	C-type lectin domain family 4, member F	563	C-type lectin.				endocytosis	integral to membrane	receptor activity|sugar binding			endometrium(1)|large_intestine(5)|lung(18)|ovary(5)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	37						AATATACTTTCTGAGTGGGCA	0.527000													3	7					0	0	1	0	0
CAPN15	6650	broad.mit.edu	37	16	601362	601362	+	Silent	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr16:601362G>A	ENST00000219611.2	+	8	2490	c.2127G>A	c.(2125-2127)gaG>gaA	p.E709E	LA16c-366D1.3_ENST00000565879.1_RNA	NM_005632.2	NP_005623.1			calpain 15																		CGGCCTACGAGAGCCTGGGCC	0.687000													15	15					0	0	1	0	0
FUK	197258	broad.mit.edu	37	16	70497655	70497655	+	Missense_Mutation	SNP	T	T	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr16:70497655T>G	ENST00000288078.6	+	3	444	c.212T>G	c.(211-213)cTg>cGg	p.L71R	FUK_ENST00000571514.1_Intron|FUK_ENST00000428974.2_Missense_Mutation_p.L71R|FUK_ENST00000378912.2_Missense_Mutation_p.L71R	NM_145059.2	NP_659496.2	Q8N0W3	FUK_HUMAN	fucokinase	71						cytoplasm	ATP binding|fucokinase activity	p.L71P(1)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(11)|ovary(2)|prostate(2)	23		Ovarian(137;0.0694)				GCTGAACACCTGAGTGCCCGG	0.637000													8	7					0	0	1	0	0
AGAP2	116986	broad.mit.edu	37	12	58124378	58124378	+	Silent	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:58124378T>C	ENST00000257897.3	-	12	1405	c.1320A>G	c.(1318-1320)ccA>ccG	p.P440P	AGAP2_ENST00000547588.1_Silent_p.P776P	NM_014770.3	NP_055585.1	Q99490	AGAP2_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	776	G domain.				axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding			breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|large_intestine(7)|lung(20)|prostate(3)|skin(1)|stomach(1)	48						GGCTAGGGCTTGGCATGGGAG	0.567000													24	61					0	0	1	0	0
ZCCHC11	23318	broad.mit.edu	37	1	52924025	52924025	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:52924025T>C	ENST00000371544.3	-	20	3680	c.3418A>G	c.(3418-3420)Atc>Gtc	p.I1140V	ZCCHC11_ENST00000257177.4_Missense_Mutation_p.I1140V	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11	1140					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						AGAACTGGGATAACAGGTGGC	0.383000													13	68					0	0	1	0	0
SCAF11	9169	broad.mit.edu	37	12	46316346	46316346	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:46316346T>C	ENST00000465950.1	-	4	4409	c.3200A>G	c.(3199-3201)aAa>aGa	p.K1067R	SCAF11_ENST00000369367.3_Missense_Mutation_p.K1382R|SCAF11_ENST00000419565.2_Missense_Mutation_p.K1382R|SCAF11_ENST00000550629.1_5'UTR|SCAF11_ENST00000549162.1_Missense_Mutation_p.K1190R			Q99590	SCAFB_HUMAN	SR-related CTD-associated factor 11	1382					spliceosome assembly	nucleus	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						TTGTGCTGCTTTTTCTTGAAT	0.308000													16	21					0	0	1	0	0
C9orf96	169436	broad.mit.edu	37	9	136256517	136256517	+	Silent	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr9:136256517G>C	ENST00000371957.3	+	7	635	c.528G>C	c.(526-528)ctG>ctC	p.L176L	C9orf96_ENST00000371955.1_5'UTR	NM_153710.3	NP_714921.4	Q8NE28	SGK71_HUMAN	chromosome 9 open reading frame 96	176	Protein kinase.						ATP binding|protein kinase activity			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|stomach(2)	25				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		TGCAGGACCTGAGTTCCAATG	0.547000													90	232					0	0	1	0	0
ETV1	2115	broad.mit.edu	37	7	13946145	13946145	+	Silent	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr7:13946145A>G	ENST00000343495.5	-	11	1704	c.966T>C	c.(964-966)ttT>ttC	p.F322F	ETV1_ENST00000403685.1_Silent_p.F322F|ETV1_ENST00000405358.4_Silent_p.F354F|ETV1_ENST00000430479.1_Silent_p.F340F|ETV1_ENST00000405218.2_Silent_p.F340F|ETV1_ENST00000403527.1_Silent_p.F300F|ETV1_ENST00000399357.3_Silent_p.F237F|ETV1_ENST00000242066.5_Silent_p.F322F|ETV1_ENST00000405192.2_Silent_p.F317F|ETV1_ENST00000420159.2_Silent_p.F282F			P50549	ETV1_HUMAN	ets variant 1	340					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(34)|ACSL3_ENST00000357430/ETV1(2)|EWSR1/ETV1(7)|KLK2/ETV1(3)|SLC45A3/ETV1(3)|HNRNPA2B1/ETV1(8)	breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31						GAGCTACCAAAAACTGCCAGA	0.423000			T	"""EWSR1, TMPRSS2, SLC45A3, C15orf21, HNRNPA2B1. ACSL3"""	"""Ewing sarcoma, prostate"""								10	3					0	0	1	0	0
RPL26L1	51121	broad.mit.edu	37	5	172395499	172395499	+	Missense_Mutation	SNP	A	A	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr5:172395499A>T	ENST00000521476.1	+	3	330	c.206A>T	c.(205-207)aAg>aTg	p.K69M	RPL26L1_ENST00000519974.1_Missense_Mutation_p.K69M|RPL26L1_ENST00000519239.1_Missense_Mutation_p.K69M|RPL26L1_ENST00000265100.2_Missense_Mutation_p.K69M			Q9UNX3	RL26L_HUMAN	ribosomal protein L26-like 1	69					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|large ribosomal subunit	structural constituent of ribosome			breast(1)|endometrium(1)|kidney(1)|lung(2)|prostate(1)|urinary_tract(1)	7	Renal(175;0.000159)|Lung NSC(126;0.00344)|all_lung(126;0.00594)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CAAATTGGCAAGGTAGTCCAG	0.473000													36	92					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103074454	103074454	+	Missense_Mutation	SNP	C	C	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr11:103074454C>G	ENST00000375735.2	+	51	8404	c.8260C>G	c.(8260-8262)Caa>Gaa	p.Q2754E	DYNC2H1_ENST00000398093.3_Missense_Mutation_p.Q2754E|DYNC2H1_ENST00000334267.7_Intron	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2754	AAA 4 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		ACTTAAGGATCAAGCTTCACA	0.318000													10	23					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113871484	113871484	+	Missense_Mutation	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr8:113871484C>T	ENST00000297405.5	-	11	1889	c.1645G>A	c.(1645-1647)Ggc>Agc	p.G549S	CSMD3_ENST00000343508.3_Missense_Mutation_p.G509S|CSMD3_ENST00000352409.3_Missense_Mutation_p.G549S|CSMD3_ENST00000455883.2_Missense_Mutation_p.G445S	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	549	CUB 3.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AGATTAGAGCCACACGTTTTC	0.358000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			14	40					0	0	1	0	0
TUBA1A	7846	broad.mit.edu	37	12	49580178	49580178	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:49580178T>C	ENST00000301071.7	-	3	634	c.290A>G	c.(289-291)gAa>gGa	p.E97G	TUBA1A_ENST00000295766.5_Missense_Mutation_p.E97G|TUBA1A_ENST00000546918.1_Missense_Mutation_p.K148E|TUBA1A_ENST00000550767.1_Missense_Mutation_p.E62G	NM_001270400.1|NM_006009.3	NP_001257329.1|NP_006000.2	Q71U36	TBA1A_HUMAN	tubulin, alpha 1a	97					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|structural molecule activity			stomach(1)|upper_aerodigestive_tract(1)	2						GGCAGCATCTTCTTTGCCTGT	0.527000													6	108					0	0	1	0	0
H6PD	9563	broad.mit.edu	37	1	9324446	9324446	+	Missense_Mutation	SNP	A	A	G			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr1:9324446A>G	ENST00000377403.2	+	5	2196	c.1894A>G	c.(1894-1896)Aac>Gac	p.N632D	H6PD_ENST00000602477.1_Missense_Mutation_p.N643D	NM_001282587.1|NM_004285.3	NP_001269516.1|NP_004276.2	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	632	6-phosphogluconolactonase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)	CCCGGAGTCCAACTTCCAGGG	0.667000													9	29					0	0	1	0	0
RRAGB	10325	broad.mit.edu	37	X	55784734	55784734	+	Silent	SNP	G	G	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chrX:55784734G>C	ENST00000374941.4	+	10	1588	c.999G>C	c.(997-999)ctG>ctC	p.L333L	RRAGB_ENST00000262850.7_Silent_p.L361L	NM_006064.4	NP_006055.3	Q5VZM2	RRAGB_HUMAN	Ras-related GTP binding B	361					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|signal transduction	Golgi apparatus|lysosome|nucleus	GTP binding|protein binding	p.L361L(1)		breast(1)|endometrium(3)|large_intestine(5)|lung(3)|pancreas(1)|prostate(1)	14						TTGAAAAGCTGGAAAGAGTGG	0.423000													9	10					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	233925207	233925207	+	Missense_Mutation	SNP	C	C	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:233925207C>A	ENST00000359570.5	+	1	19	c.19C>A	c.(19-21)Cat>Aat	p.H7N	INPP5D_ENST00000538935.1_Missense_Mutation_p.H7N			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	7	SH2.				apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		CTGCTGGAACCATGGCAACAT	0.692000													3	8					0.004672	0.00468287	1	1	0
ZNF699	374879	broad.mit.edu	37	19	9408081	9408081	+	Nonsense_Mutation	SNP	G	G	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:9408081G>A	ENST00000591998.1	-	5	589	c.361C>T	c.(361-363)Cag>Tag	p.Q121*	ZNF699_ENST00000308650.3_Nonsense_Mutation_p.Q121*			Q32M78	ZN699_HUMAN	zinc finger protein 699	121					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						ACTATTTTCTGTTCATTGGAT	0.343000													38	46					0	0	1	0	0
MYO1A	4640	broad.mit.edu	37	12	57424015	57424015	+	Missense_Mutation	SNP	T	T	C			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:57424015T>C	ENST00000442789.2	-	25	2857	c.2570A>G	c.(2569-2571)aAg>aGg	p.K857R	MYO1A_ENST00000544473.1_Missense_Mutation_p.K695R|MYO1A_ENST00000300119.3_Missense_Mutation_p.K857R	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	857					sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						TGAAGCCTTCTTGCCCTTGAA	0.557000													22	40					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40424045	40424045	+	Missense_Mutation	SNP	C	C	T			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:40424045C>T	ENST00000221347.6	-	4	2165	c.2158G>A	c.(2158-2160)Gcc>Acc	p.A720T		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	720						extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TGGGCATAGGCGCTGAGGCCA	0.642000													16	45					0	0	1	0	0
TAF1B	9014	broad.mit.edu	37	2	10073952	10073953	+	In_Frame_Ins	INS	-	-	ATA			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:10073952_10073953insATA	ENST00000263663.5	+	15	1794_1795	c.1606_1607insATA	c.(1606-1608)tct>tATAct	p.536_536S>YT	TAF1B_ENST00000396242.3_In_Frame_Ins_p.281_281S>YT	NM_005680.2	NP_005671	Q53T94	TAF1B_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa	536					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	14	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					ATCAAATTATTCTCTGAGTTAT	0.337													12	47	---	---	---	---					
LINC01122	400955	broad.mit.edu	37	2	58687297	58687298	+	RNA	INS	-	-	T	rs142388743	by1000genomes	TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr2:58687297_58687298insT	ENST00000452840.1	+	0	127																											ATCTGTGTTTCTTTTTTTTTTC	0.312													2	4	---	---	---	---					
SLC9C1	285335	broad.mit.edu	37	3	111923223	111923224	+	Frame_Shift_Del	DEL	AA	AA	-			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr3:111923223_111923224delAA	ENST00000305815.5	-	17	2265_2266	c.2013_2014delTT	c.(2011-2016)ttttcafs	p.S672fs	SLC9C1_ENST00000487372.1_Frame_Shift_Del_p.S624fs	NM_183061.1	NP_898884.1	Q4G0N8	S9A10_HUMAN	solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1	672	Ion transport-like.				cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity										CAGGCATGTGAAAAAAAGTCCT	0.292													72	171	---	---	---	---					
DAPP1	27071	broad.mit.edu	37	4	100784959	100784960	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr4:100784959_100784960delAG	ENST00000296414.7	+	7	714_715	c.633_634delAG	c.(631-636)acagaafs	p.E212fs	DAPP1_ENST00000512369.1_Frame_Shift_Del_p.E212fs			Q9UN19	DAPP1_HUMAN	dual adaptor of phosphotyrosine and 3-phosphoinositides	212	PH.				signal transduction	cytoplasm|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein tyrosine phosphatase activity			endometrium(1)|kidney(1)|lung(4)	6				OV - Ovarian serous cystadenocarcinoma(123;7.04e-09)		TAGACCTAACAGAATGTTCAGC	0.317													4	6	---	---	---	---					
CCRN4L	25819	broad.mit.edu	37	4	139966226	139966231	+	In_Frame_Del	DEL	AGCTCA	AGCTCA	-			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr4:139966226_139966231delAGCTCA	ENST00000280614.2	+	3	1087_1092	c.894_899delAGCTCA	c.(892-900)tcagctcaa>tca	p.AQ299del	ELF2_ENST00000515489.1_Intron	NM_012118.2	NP_036250.2	Q9UK39	NOCT_HUMAN	CCR4 carbon catabolite repression 4-like (S. cerevisiae)	299					rhythmic process|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			kidney(2)|large_intestine(3)|lung(3)|ovary(1)	9	all_hematologic(180;0.162)					GGTTTCGATCAGCTCAAGGCTGTGAC	0.539													9	35	---	---	---	---					
DDB2	1643	broad.mit.edu	37	11	47254498	47254499	+	Frame_Shift_Ins	INS	-	-	A			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr11:47254498_47254499insA	ENST00000256996.4	+	4	785_786	c.590_591insA	c.(589-594)tcagacfs	p.D198fs	DDB2_ENST00000378600.3_Intron|DDB2_ENST00000378603.3_Frame_Shift_Ins_p.D134fs|DDB2_ENST00000378601.3_Frame_Shift_Ins_p.D198fs	NM_000107.2	NP_000098.1	Q92466	DDB2_HUMAN	damage-specific DNA binding protein 2, 48kDa	198					nucleotide-excision repair, DNA damage removal|protein autoubiquitination|protein polyubiquitination|response to UV	nucleoplasm|protein complex	damaged DNA binding|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(1)	17						TTTGCCAGCTCAGACACCATCA	0.460			"""Mis, N"""			"""skin basal cell, skin squamous cell, melanoma"""		Direct reversal of damage;Nucleotide excision repair (NER)	Xeroderma Pigmentosum				37	62	---	---	---	---					
SSH1	54434	broad.mit.edu	37	12	109203535	109203536	+	Splice_Site	DEL	CT	CT	-			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr12:109203535_109203536delCT	ENST00000326495.5	-	7	564		c.e7-1		SSH1_ENST00000326470.5_Splice_Site|SSH1_ENST00000360239.3_Splice_Site|SSH1_ENST00000551165.1_Splice_Site	NM_018984.3	NP_061857.3	Q8WYL5	SSH1_HUMAN	slingshot protein phosphatase 1						actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						GCTGAACCCACTGAGAATAAAA	0.500													32	66	---	---	---	---					
SLITRK6	84189	broad.mit.edu	37	13	86368645	86368649	+	Frame_Shift_Del	DEL	GAGTG	GAGTG	-			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr13:86368645_86368649delGAGTG	ENST00000400286.2	-	2	2593_2597	c.1995_1999delCACTC	c.(1993-2001)accactcatfs	p.TH666fs		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	666						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		GTAGTGTGATGAGTGGTTTTATGGC	0.444													47	74	---	---	---	---					
IPO5	3843	broad.mit.edu	37	13	98664556	98664556	+	Frame_Shift_Del	DEL	C	C	-			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr13:98664556delC	ENST00000261574.5	+	21	2346	c.2166delC	c.(2164-2166)gtcfs	p.V722fs	IPO5_ENST00000490680.1_Frame_Shift_Del_p.V704fs|IPO5_ENST00000539640.1_Frame_Shift_Del_p.V579fs	NM_002271.4	NP_002262.3	O00410	IPO5_HUMAN	importin 5	704					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			breast(2)|endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	27						AACAGGTTGTCAAACTGATGG	0.363													18	73	---	---	---	---					
SLC15A1	6564	broad.mit.edu	37	13	99373822	99373823	+	Frame_Shift_Del	DEL	TC	TC	-	rs79092209		TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr13:99373822_99373823delTC	ENST00000376503.5	-	7	537_538	c.482_483delGA	c.(481-483)agafs	p.R161fs		NM_005073.3	NP_005064.1	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide transporter), member 1	161					digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	30	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	TGGAAAAAAATCTGTTTCTTTG	0.391													10	28	---	---	---	---					
KNSTRN	90417	broad.mit.edu	37	15	40678579	40678591	+	Frame_Shift_Del	DEL	CACTTCTAAGAGT	CACTTCTAAGAGT	-			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr15:40678579_40678591delCACTTCTAAGAGT	ENST00000416151.2	+	3	436_448	c.321_333delCACTTCTAAGAGT	c.(319-333)gccacttctaagagtfs	p.ATSKS107fs	KNSTRN_ENST00000608100.1_Frame_Shift_Del_p.ATSKS29fs|KNSTRN_ENST00000249776.8_Frame_Shift_Del_p.ATSKS107fs|KNSTRN_ENST00000448395.2_Frame_Shift_Del_p.ATSKS107fs	NM_001142761.1	NP_001136233.1			kinetochore-localized astrin/SPAG5 binding protein																		AAACTCGGGCCACTTCTAAGAGTCTCTTACCTG	0.451													10	46	---	---	---	---					
CPNE2	221184	broad.mit.edu	37	16	57153531	57153532	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr16:57153531_57153532delTG	ENST00000535318.2	+	8	1011_1012	c.650_651delTG	c.(649-651)ctgfs	p.L217fs	CPNE2_ENST00000537605.1_Frame_Shift_Del_p.L115fs|CPNE2_ENST00000290776.8_Frame_Shift_Del_p.L217fs|CPNE2_ENST00000565874.1_Frame_Shift_Del_p.L217fs			Q96FN4	CPNE2_HUMAN	copine II	217	C2 2.									central_nervous_system(2)|endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|skin(5)	21		all_neural(199;0.224)				TTGGTGTCCCTGTGTGATGGGG	0.624													7	12	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7578222	7578223	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr17:7578222_7578223delTC	ENST00000420246.2	-	6	758_759	c.626_627delGA	c.(625-627)agafs	p.R209fs	TP53_ENST00000413465.2_Frame_Shift_Del_p.R209fs|TP53_ENST00000455263.2_Frame_Shift_Del_p.R209fs|TP53_ENST00000359597.4_Frame_Shift_Del_p.R209fs|TP53_ENST00000574684.1_Intron|TP53_ENST00000445888.2_Frame_Shift_Del_p.R209fs|TP53_ENST00000269305.4_Frame_Shift_Del_p.R209fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	209	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		R -> I (in sporadic cancers; somatic mutation).|R -> K (in sporadic cancers; somatic mutation).|R -> S (in a sporadic cancer; somatic mutation).|R -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R209fs*6(38)|p.0?(8)|p.R209K(7)|p.?(5)|p.R209T(3)|p.R77fs*6(2)|p.R209fs*35(2)|p.D207fs*6(2)|p.R209fs*38(2)|p.R116fs*6(2)|p.R77K(1)|p.R116K(1)|p.E204_N210delEYLDDRN(1)|p.R209fs*36(1)|p.D207_R213delDDRNTFR(1)|p.D208_V216delDRNTFRHSV(1)|p.D208fs*1(1)|p.N210fs*7(1)|p.R209S(1)|p.R209I(1)|p.R209_R213delRNTFR(1)|p.D207_V216del10(1)|p.R209fs*5(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAAAAGTGTTTCTGTCATCCAA	0.535		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			22	14	---	---	---	---					
GNA15	2769	broad.mit.edu	37	19	3148681	3148681	+	Frame_Shift_Del	DEL	C	C	-			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:3148681delC	ENST00000262958.3	+	2	496	c.238delC	c.(238-240)cccfs	p.P80fs	AC005264.2_ENST00000587587.1_RNA	NM_002068.2	NP_002059.2	P30679	GNA15_HUMAN	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	80					activation of phospholipase C activity by dopamine receptor signaling pathway|activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			large_intestine(5)|lung(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.04e-05)|OV - Ovarian serous cystadenocarcinoma(105;5.08e-113)|Epithelial(107;6.19e-111)|all cancers(105;6.19e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00145)|STAD - Stomach adenocarcinoma(1328;0.184)		GGGCTTCCGGCCCCTGGTCTA	0.637													2	4	---	---	---	---					
ZNF600	162966	broad.mit.edu	37	19	53270442	53270443	+	Frame_Shift_Del	DEL	TT	TT	-			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:53270442_53270443delTT	ENST00000338230.3	-	3	833_834	c.566_567delAA	c.(565-567)caafs	p.Q189fs		NM_198457.2	NP_940859	Q6ZNG1	ZN600_HUMAN	zinc finger protein 600	189					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(9)|liver(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(262;0.0241)|GBM - Glioblastoma multiforme(134;0.0404)		CACATTTATATTGTTTGTCTCC	0.371													47	176	---	---	---	---					
LILRB1	10859	broad.mit.edu	37	19	55146148	55146150	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr19:55146148_55146150delCTC	ENST00000396331.1	+	11	1774_1776	c.1417_1419delCTC	c.(1417-1419)ctcdel	p.L479del	LILRB1_ENST00000396317.1_In_Frame_Del_p.L463del|LILRB1_ENST00000427581.2_In_Frame_Del_p.L529del|LILRB1_ENST00000462628.1_3'UTR|LILRB1_ENST00000396327.3_In_Frame_Del_p.L480del|LILRB1_ENST00000396321.2_In_Frame_Del_p.L479del|LILRB1_ENST00000418536.2_In_Frame_Del_p.L463del|LILRB1_ENST00000324602.7_In_Frame_Del_p.L480del|LILRB1_ENST00000396315.1_In_Frame_Del_p.L480del|LILRB1_ENST00000448689.1_In_Frame_Del_p.L479del|LILRB1_ENST00000396332.4_In_Frame_Del_p.L479del|LILRB1_ENST00000434867.2_In_Frame_Del_p.L479del	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	479					regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		CAtcctactgctcctcctcctcc	0.581										HNSCC(37;0.09)			7	72	---	---	---	---					
ZNF337	26152	broad.mit.edu	37	20	25656810	25656811	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chr20:25656810_25656811delCT	ENST00000376436.1	-	4	1652_1653	c.1113_1114delAG	c.(1111-1116)tcagggfs	p.G372fs	RP4-694B14.5_ENST00000439498.1_RNA|ZNF337_ENST00000538750.1_Frame_Shift_Del_p.G340fs|RP4-694B14.5_ENST00000414393.1_RNA|ZNF337_ENST00000252979.5_Frame_Shift_Del_p.G372fs|RP4-694B14.5_ENST00000455791.1_RNA					zinc finger protein 337											breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						GGCTTCTCCCCTGAGTGTGTCC	0.500													15	94	---	---	---	---					
TFE3	7030	broad.mit.edu	37	X	48887952	48887952	+	Frame_Shift_Del	DEL	C	C	-			TCGA-UY-A8OB-01A-12D-A42E-08	TCGA-UY-A8OB-11A-12D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed352cfc-4090-4900-b7dc-a0a7a35ca96b	84481ebf-c9aa-4a72-b49b-8bb6beec0ba0	g.chrX:48887952delC	ENST00000315869.7	-	10	1704	c.1445delG	c.(1444-1446)ggafs	p.G482fs		NM_006521.4	NP_006512.2	P19532	TFE3_HUMAN	transcription factor binding to IGHM enhancer 3	482					humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		NONO/TFE3(2)|PRCC/TFE3(25)|SFPQ/TFE3(6)|CLTC/TFE3(2)|ASPSCR1/TFE3(167)	central_nervous_system(1)	1						CTGGGCAGGTCCCCCCCCTAC	0.647			T	"""SFPQ, ASPSCR1, PRCC, NONO, CLTC"""	"""papillary renal, alveolar soft part sarcoma, renal"""								7	77	---	---	---	---					
