Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CTC-260E6.6	0	broad.mit.edu	37	19	20369712	20369712	+	RNA	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:20369712G>T	ENST00000593655.1	-	0	199																											GTGTTACGTGGGATATAATAT	0.393000													12	55					4.36969e-10	5.98107e-10	1	1	0
PARP15	165631	broad.mit.edu	37	3	122345737	122345737	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:122345737C>T	ENST00000464300.2	+	9	1361	c.1295C>T	c.(1294-1296)tCa>tTa	p.S432L	PARP15_ENST00000465304.1_3'UTR|PARP15_ENST00000483793.1_Intron|PARP15_ENST00000310366.4_Missense_Mutation_p.S198L|PARP15_ENST00000493645.1_Intron	NM_001113523.1	NP_001106995.1	Q460N3	PAR15_HUMAN	poly (ADP-ribose) polymerase family, member 15	410	Macro 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	NAD+ ADP-ribosyltransferase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	24				GBM - Glioblastoma multiforme(114;0.0531)		GTAGACTTCTCATCACAACAT	0.358000													4	64					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154157100	154157100	+	Silent	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:154157100G>A	ENST00000360256.4	-	14	5165	c.4965C>T	c.(4963-4965)tgC>tgT	p.C1655C		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	1655	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	GGTTTTGAGAGCACAGCCTTT	0.428000													13	69					0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115997457	115997457	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr4:115997457A>G	ENST00000264363.2	-	2	1414	c.736T>C	c.(736-738)Tcc>Ccc	p.S246P		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	246	Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		CTAGACAAGGATGACAGGGAT	0.423000													14	87					0	0	1	0	0
MYO18A	399687	broad.mit.edu	37	17	27425197	27425197	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:27425197C>G	ENST00000527372.1	-	25	4096	c.3916G>C	c.(3916-3918)Gag>Cag	p.E1306Q	MYO18A_ENST00000533112.1_Missense_Mutation_p.E1306Q|MYO18A_ENST00000354329.4_Missense_Mutation_p.E1306Q|MYO18A_ENST00000531253.1_Missense_Mutation_p.E1306Q	NM_078471.3	NP_510880.2	Q92614	MY18A_HUMAN	myosin XVIIIA	1306					anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity			NS(1)|cervix(1)|endometrium(6)|kidney(6)|lung(20)|urinary_tract(2)	36			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			GAGGCGGACTCTCCTGTGTTA	0.607000													16	154					0	0	1	0	0
KCNK6	9424	broad.mit.edu	37	19	38817243	38817243	+	Nonsense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:38817243C>G	ENST00000263372.3	+	2	440	c.333C>G	c.(331-333)taC>taG	p.Y111*		NM_004823.1	NP_004814.1	Q9Y257	KCNK6_HUMAN	potassium channel, subfamily K, member 6	111						voltage-gated potassium channel complex	inward rectifier potassium channel activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(3)	17	all_cancers(60;5.83e-07)		Lung(45;0.00047)|LUSC - Lung squamous cell carcinoma(53;0.000613)		Ibutilide(DB00308)|Quinidine(DB00908)	GCTATGGGTACACAACGCCAC	0.587000													6	109					0	0	1	0	0
ABCF1	23	broad.mit.edu	37	6	30552007	30552007	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr6:30552007C>G	ENST00000326195.8	+	13	1253	c.1141C>G	c.(1141-1143)Ctt>Gtt	p.L381V	ABCF1_ENST00000376545.3_Missense_Mutation_p.L343V|ABCF1_ENST00000396515.4_Intron	NM_001025091.1	NP_001020262.1	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F (GCN20), member 1	381	ABC transporter 1.				inflammatory response|translational initiation	nuclear envelope|nucleoplasm|polysomal ribosome	ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(3)|skin(2)	21						CCAGGCTGTTCTTCGAGCTGA	0.562000													5	47					0	0	1	0	0
GNL3	26354	broad.mit.edu	37	3	52723201	52723201	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:52723201G>T	ENST00000394799.2	+	6	694	c.484G>T	c.(484-486)Gta>Tta	p.V162L	GNL3_ENST00000418458.1_Missense_Mutation_p.V174L	NM_206825.1	NP_996561.1	Q9BVP2	GNL3_HUMAN	guanine nucleotide binding protein-like 3 (nucleolar)	174					regulation of cell proliferation	nucleolus	GTP binding|protein binding			breast(4)|endometrium(3)|large_intestine(3)|lung(2)	12				BRCA - Breast invasive adenocarcinoma(193;6.75e-05)|Kidney(197;0.000611)|KIRC - Kidney renal clear cell carcinoma(197;0.000773)|OV - Ovarian serous cystadenocarcinoma(275;0.048)		GAAAAAGCTGGTACTTATATT	0.458000													10	88					0.00829132	0.00913058	1	1	0
DZIP1	22873	broad.mit.edu	37	13	96246271	96246271	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr13:96246271G>C	ENST00000347108.3	-	14	2039	c.1607C>G	c.(1606-1608)tCc>tGc	p.S536C	DZIP1_ENST00000376829.2_Missense_Mutation_p.S536C|DZIP1_ENST00000361156.3_Missense_Mutation_p.S517C|DZIP1_ENST00000361396.2_Missense_Mutation_p.S517C			Q86YF9	DZIP1_HUMAN	DAZ interacting zinc finger protein 1	536					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(20)|lung(11)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	38	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			CTTAGTGAGGGAGGAGTTACT	0.333000													4	50					0	0	1	0	0
SUSD1	64420	broad.mit.edu	37	9	114842402	114842402	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr9:114842402G>T	ENST00000374270.3	-	11	1690	c.1518C>A	c.(1516-1518)tgC>tgA	p.C506*	SUSD1_ENST00000374264.2_Nonsense_Mutation_p.C506*|SUSD1_ENST00000374263.3_Nonsense_Mutation_p.C506*	NM_022486.3	NP_071931.2	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1	506						integral to membrane	calcium ion binding		SUSD1/ROD1(2)	central_nervous_system(1)|endometrium(4)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28						TCCATCTCAAGCAGGTTTCAT	0.353000													6	66					8.12818e-05	9.75073e-05	1	1	0
SMO	6608	broad.mit.edu	37	7	128846324	128846324	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:128846324G>C	ENST00000249373.3	+	6	1440	c.1160G>C	c.(1159-1161)aGt>aCt	p.S387T		NM_005631.4	NP_005622.1	Q99835	SMO_HUMAN	smoothened, frizzled family receptor	387					adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			biliary_tract(1)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(14)|liver(1)|lung(11)|pancreas(2)|prostate(1)|skin(20)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						GACTCTGTGAGTGGGATTTGT	0.592000			Mis		skin basal cell								7	105					0	0	1	0	0
DAGLB	221955	broad.mit.edu	37	7	6485700	6485700	+	Missense_Mutation	SNP	C	C	G	rs138752821		TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:6485700C>G	ENST00000297056.6	-	2	300	c.131G>C	c.(130-132)aGa>aCa	p.R44T	DAGLB_ENST00000428902.2_5'UTR|DAGLB_ENST00000479922.2_5'UTR|DAGLB_ENST00000436575.1_Missense_Mutation_p.R3T|DAGLB_ENST00000421761.2_5'UTR|DAGLB_ENST00000425398.2_Missense_Mutation_p.R44T|KDELR2_ENST00000463747.1_5'UTR	NM_139179.3	NP_631918.3	Q8NCG7	DGLB_HUMAN	diacylglycerol lipase, beta	44					lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|urinary_tract(2)	26		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)		CAGCTTTCCTCTGTGCATGAG	0.463000													7	48					0	0	1	0	0
ADRB2	154	broad.mit.edu	37	5	148207139	148207139	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:148207139G>C	ENST00000305988.4	+	1	984	c.745G>C	c.(745-747)Gag>Cag	p.E249Q		NM_000024.5	NP_000015	P07550	ADRB2_HUMAN	adrenoceptor beta 2, surface	249					activation of transmembrane receptor protein tyrosine kinase activity|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|endosome to lysosome transport|positive regulation of MAPKKK cascade|receptor-mediated endocytosis	endosome|integral to plasma membrane|lysosome|receptor complex	beta2-adrenergic receptor activity|norepinephrine binding|potassium channel regulator activity|protein homodimerization activity			endometrium(1)|kidney(1)|lung(8)|ovary(1)|prostate(3)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Alprenolol(DB00866)|Arformoterol(DB01274)|Bambuterol(DB01408)|Bisoprolol(DB00612)|Bitolterol(DB00901)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Clenbuterol(DB01407)|Desipramine(DB01151)|Epinephrine(DB00668)|Fenoterol(DB01288)|Formoterol(DB00983)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Nadolol(DB01203)|Norepinephrine(DB00368)|Orciprenaline(DB00816)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Pirbuterol(DB01291)|Procaterol(DB01366)|Propranolol(DB00571)|Pseudoephedrine(DB00852)|Ritodrine(DB00867)|Salbutamol(DB01001)|Salmeterol(DB00938)|Terbutaline(DB00871)|Timolol(DB00373)	TAGCCAGGTGGAGCAGGATGG	0.547000													7	25					0	0	1	0	0
ASMTL	8623	broad.mit.edu	37	X	1531685	1531685	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:1531685C>A	ENST00000534940.1	-	12	1636	c.1411G>T	c.(1411-1413)Gac>Tac	p.D471Y	ASMTL-AS1_ENST00000420411.2_RNA|ASMTL-AS1_ENST00000602357.1_RNA|ASMTL_ENST00000416733.2_Missense_Mutation_p.D453Y|ASMTL-AS1_ENST00000419737.2_RNA|ASMTL-AS1_ENST00000425740.2_RNA|ASMTL_ENST00000381317.3_Missense_Mutation_p.D529Y|ASMTL_ENST00000381333.4_Missense_Mutation_p.D513Y	NM_001173473.1	NP_001166944.1	O95671	ASML_HUMAN	acetylserotonin O-methyltransferase-like	529	ASMT-like.				melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|lung(9)|pancreas(1)|soft_tissue(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TCTGGCCAGTCATGCAGGATC	0.542000													4	170					1	1	1	1	0
FLVCR1	28982	broad.mit.edu	37	1	213046044	213046044	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:213046044C>T	ENST00000366971.4	+	3	1106	c.908C>T	c.(907-909)cCa>cTa	p.P303L		NM_014053.3	NP_054772.1	Q9Y5Y0	FLVC1_HUMAN	feline leukemia virus subgroup C cellular receptor 1	303					cell death|cellular iron ion homeostasis|heme export|transmembrane transport	integral to plasma membrane	heme transporter activity|protein binding|receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(2)	12				OV - Ovarian serous cystadenocarcinoma(81;0.00733)|all cancers(67;0.013)|GBM - Glioblastoma multiforme(131;0.0845)|Epithelial(68;0.11)		CCTCGGTATCCACCAAGTCAG	0.323000													3	55					0	0	1	0	0
ISCA2	122961	broad.mit.edu	37	14	74961577	74961577	+	Silent	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr14:74961577G>A	ENST00000556816.1	+	4	394	c.339G>A	c.(337-339)ttG>ttA	p.L113L	ISCA2_ENST00000298818.8_3'UTR|ISCA2_ENST00000554924.1_3'UTR			Q86U28	ISCA2_HUMAN	iron-sulfur cluster assembly 2	113					iron-sulfur cluster assembly	mitochondrion	iron-sulfur cluster binding|metal ion binding|structural molecule activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00146)		CTGATAGCTTGGCCTTCGTGA	0.493000													4	63					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34100945	34100945	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr6:34100945G>A	ENST00000538487.2	-	2	772	c.329C>T	c.(328-330)tCc>tTc	p.S110F	GRM4_ENST00000374177.3_Intron|GRM4_ENST00000374181.4_Missense_Mutation_p.S110F	NM_000841.2|NM_001256811.1	NP_000832.1|NP_001243740.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4						activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	GGTGTCCCTGGAGCAGGTGTC	0.647000													4	12					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29430114	29430114	+	Silent	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:29430114G>T	ENST00000389048.3	-	26	4767	c.3861C>A	c.(3859-3861)ggC>ggA	p.G1287G	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	1287	Protein kinase.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GCATGGCACAGCCTCCCTTTC	0.502000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				6	29					1	1	1	1	0
MCTP2	55784	broad.mit.edu	37	15	95022218	95022218	+	Silent	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr15:95022218C>G	ENST00000357742.4	+	22	2592	c.2592C>G	c.(2590-2592)ctC>ctG	p.L864L	MCTP2_ENST00000449432.3_3'UTR|MCTP2_ENST00000451018.3_Silent_p.L809L	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	864					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			AATTGAAACTCTGCAGCAGCC	0.542000													14	56					0	0	1	0	0
ABCC2	1244	broad.mit.edu	37	10	101611269	101611269	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr10:101611269C>A	ENST00000370449.4	+	32	4632	c.4519C>A	c.(4519-4521)Cta>Ata	p.L1507I		NM_000392.3	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	1507	ABC transporter 2.					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GGTAATGGTCCTAGACAACGG	0.413000													5	79					0.000602214	0.000695966	1	1	0
DLGAP4	22839	broad.mit.edu	37	20	35060912	35060912	+	Silent	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr20:35060912G>A	ENST00000373913.3	+	3	1272	c.792G>A	c.(790-792)ctG>ctA	p.L264L	DLGAP4_ENST00000339266.5_Silent_p.L264L|DLGAP4_ENST00000373907.2_Silent_p.L264L|DLGAP4_ENST00000401952.2_Silent_p.L264L			Q9Y2H0	DLGP4_HUMAN	discs, large (Drosophila) homolog-associated protein 4	264					cell-cell signaling	membrane	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(20)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CTACTGAGCTGACTGCCCCAC	0.627000													4	27					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168845771	168845771	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:168845771G>A	ENST00000464456.1	-	4	1327	c.127C>T	c.(127-129)Cca>Tca	p.P43S	MECOM_ENST00000468789.1_Missense_Mutation_p.P43S|MECOM_ENST00000264674.3_Missense_Mutation_p.P107S|MECOM_ENST00000392736.3_Missense_Mutation_p.P43S|MECOM_ENST00000472280.1_Missense_Mutation_p.P43S|MECOM_ENST00000494292.1_Missense_Mutation_p.P231S|MECOM_ENST00000460814.1_Missense_Mutation_p.P43S|MECOM_ENST00000433243.2_Missense_Mutation_p.P43S	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						GTACTGCATGGAAACTTTTGG	0.433000													6	92					0	0	1	0	0
AK7	122481	broad.mit.edu	37	14	96909099	96909099	+	Silent	SNP	A	A	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr14:96909099A>T	ENST00000267584.4	+	7	767	c.723A>T	c.(721-723)ccA>ccT	p.P241P		NM_152327.3	NP_689540.2	Q96M32	KAD7_HUMAN	adenylate kinase 7	241					cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			breast(2)|cervix(2)|endometrium(3)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		CTGCATTACCAGTTTTTGGCG	0.428000													8	109					0	0	1	0	0
CLTC	1213	broad.mit.edu	37	17	57759678	57759678	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:57759678G>T	ENST00000269122.3	+	22	3763	c.3489G>T	c.(3487-3489)aaG>aaT	p.K1163N	CLTC_ENST00000393043.1_Missense_Mutation_p.K1163N|CLTC_ENST00000579456.1_Splice_Site	NM_004859.3	NP_004850.1	Q00610	CLH1_HUMAN	clathrin, heavy chain (Hc)	1163	Heavy chain arm.|Proximal segment.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	breast(2)|large_intestine(6)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					CCCGTAAGAAGGCTCGAGAGT	0.393000			T	"""ALK, TFE3"""	"""ALCL, renal """								26	57					2.79863e-10	3.84736e-10	1	1	0
DEF8	54849	broad.mit.edu	37	16	90021603	90021603	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr16:90021603G>C	ENST00000563594.1	+	4	1148	c.151G>C	c.(151-153)Gag>Cag	p.E51Q	DEF8_ENST00000567874.1_5'UTR|DEF8_ENST00000268676.7_Missense_Mutation_p.E112Q|DEF8_ENST00000418391.2_Missense_Mutation_p.E51Q|DEF8_ENST00000570182.1_Missense_Mutation_p.E51Q|DEF8_ENST00000563795.1_Missense_Mutation_p.E51Q|DEF8_ENST00000569453.1_Missense_Mutation_p.E51Q	NM_001242818.1|NM_001242819.1	NP_001229747.1|NP_001229748.1	Q6ZN54	DEFI8_HUMAN	differentially expressed in FDCP 8 homolog (mouse)	112					intracellular signal transduction		zinc ion binding			central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	12		all_cancers(9;7.59e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.0019)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0274)		GCCCCCTGGGGAGCCGGAATT	0.642000													8	30					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140730095	140730095	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:140730095G>C	ENST00000523390.1	+	1	268	c.268G>C	c.(268-270)Gag>Cag	p.E90Q	PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATAGATCGAGAGAAGATTTG	0.448000											OREG0016856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	45					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39450252	39450252	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr13:39450252C>A	ENST00000280481.7	+	19	8591	c.8375C>A	c.(8374-8376)cCa>cAa	p.P2792Q		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2792					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TATAACCAGCCAGTACAGCAG	0.443000													7	97					0.000274275	0.000320496	1	1	0
PRG4	10216	broad.mit.edu	37	1	186276866	186276866	+	Missense_Mutation	SNP	C	C	T	rs147683837	byFrequency	TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:186276866C>T	ENST00000445192.2	+	7	2060	c.2015C>T	c.(2014-2016)gCg>gTg	p.A672V	PRG4_ENST00000367486.3_Missense_Mutation_p.A629V|PRG4_ENST00000367485.4_Missense_Mutation_p.A579V|PRG4_ENST00000367483.4_Missense_Mutation_p.A631V|PRG4_ENST00000367484.3_Intron	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	672	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						CCCAAGGCAGCGGCTCCCAAC	0.647000													4	32					0	0	1	0	0
PDGFRA	5156	broad.mit.edu	37	4	55161419	55161419	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr4:55161419G>A	ENST00000257290.5	+	23	3581	c.3250G>A	c.(3250-3252)Gtg>Atg	p.V1084M	FIP1L1_ENST00000507166.1_Missense_Mutation_p.V844M	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	1084	Ser-rich.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	TTCAGACCTGGTGGAAGACAG	0.512000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			10	75					0	0	1	0	0
TFPI2	7980	broad.mit.edu	37	7	93516176	93516176	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:93516176G>A	ENST00000222543.5	-	5	976	c.664C>T	c.(664-666)Cgc>Tgc	p.R222C	TFPI2_ENST00000545378.1_Missense_Mutation_p.R111C|GNGT1_ENST00000455502.1_Intron	NM_001271003.1|NM_001271004.1|NM_006528.3	NP_001257932.1|NP_001257933.1|NP_006519.1	P48307	TFPI2_HUMAN	tissue factor pathway inhibitor 2	222					blood coagulation	proteinaceous extracellular matrix	extracellular matrix structural constituent|serine-type endopeptidase inhibitor activity	p.R222C(1)		endometrium(1)|large_intestine(5)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	all_cancers(62;4.45e-10)|all_epithelial(64;2.92e-09)|Lung NSC(181;0.218)		STAD - Stomach adenocarcinoma(171;0.000967)			CTGGCAAAGCGAAGCTTTGGC	0.328000													7	92					0	0	1	0	0
LEO1	123169	broad.mit.edu	37	15	52258125	52258125	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr15:52258125G>A	ENST00000299601.5	-	2	695	c.635C>T	c.(634-636)tCt>tTt	p.S212F	LEO1_ENST00000315141.5_Missense_Mutation_p.S212F	NM_138792.2	NP_620147.1	Q8WVC0	LEO1_HUMAN	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	212	Asp-rich.				histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|skin(1)	14				all cancers(107;0.00264)		TTCATCATCAGAATTAGCCTT	0.423000													16	187					0	0	1	0	0
ROPN1L	83853	broad.mit.edu	37	5	10461436	10461436	+	Silent	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:10461436G>A	ENST00000503804.1	+	5	1079	c.558G>A	c.(556-558)gaG>gaA	p.E186E	ROPN1L_ENST00000510520.1_3'UTR|ROPN1L_ENST00000274134.4_Silent_p.E186E			Q96C74	ROP1L_HUMAN	rhophilin associated tail protein 1-like	186					ciliary or flagellar motility|signal transduction	cytoplasm|motile cilium	cAMP-dependent protein kinase regulator activity|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)	14						CTCCCTTGGAGACGGAATCCT	0.507000													8	73					0	0	1	0	0
OR8D1	283159	broad.mit.edu	37	11	124179880	124179880	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:124179880C>T	ENST00000357821.2	-	1	853	c.783G>A	c.(781-783)aaG>aaA	p.K261K		NM_001002917.1	NP_001002917.1	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D, member 1	261					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(1)|lung(7)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		TTGAAGGGGGCTTGAAATACA	0.498000													15	31					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179500885	179500885	+	Missense_Mutation	SNP	T	T	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:179500885T>A	ENST00000589042.1	-	226	41637	c.41413A>T	c.(41413-41415)Aac>Tac	p.N13805Y	TTN_ENST00000460472.2_Missense_Mutation_p.N4740Y|TTN_ENST00000359218.5_Missense_Mutation_p.N4865Y|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.N4932Y|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.N12164Y|TTN_ENST00000342992.6_Missense_Mutation_p.N11237Y|TTN-AS1_ENST00000592630.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12164	Ig-like 94.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGCTCTTTGTTTAACTCGCAG	0.493000													6	12					0	0	1	0	0
MARCH1	55016	broad.mit.edu	37	4	164534481	164534481	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr4:164534481G>C	ENST00000503008.1	-	5	1203	c.227C>G	c.(226-228)aCt>aGt	p.T76S	MARCH1_ENST00000339875.5_Missense_Mutation_p.T59S|MARCH1_ENST00000514618.1_Missense_Mutation_p.T76S|MARCH1_ENST00000274056.7_Missense_Mutation_p.T76S	NM_001166373.1	NP_001159845.1	Q8TCQ1	MARH1_HUMAN	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	76					antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(20)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	36	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GATGTCCTGAGTGGATGGACA	0.423000													4	32					0	0	1	0	0
KIAA1244	57221	broad.mit.edu	37	6	138584361	138584361	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr6:138584361G>A	ENST00000251691.4	+	12	1907	c.1741G>A	c.(1741-1743)Gac>Aac	p.D581N		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	581					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		CCTGTCAGTAGACTGCAGGAC	0.473000													5	78					0	0	1	0	0
ANO9	338440	broad.mit.edu	37	11	419601	419601	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:419601C>T	ENST00000332826.6	-	20	1999	c.1915G>A	c.(1915-1917)Gaa>Aaa	p.E639K		NM_001012302.2	NP_001012302	A1A5B4	ANO9_HUMAN	anoctamin 9	639						chloride channel complex	chloride channel activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|lung(5)|ovary(1)|prostate(4)|skin(4)	21						GAGTTGCCTTCTTTCAGGCAT	0.567000													4	49					0	0	1	0	0
ZNF460	10794	broad.mit.edu	37	19	57795979	57795979	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:57795979G>A	ENST00000360338.3	+	2	413	c.91G>A	c.(91-93)Gac>Aac	p.D31N	ZNF460_ENST00000537645.1_5'UTR	NM_006635.3	NP_006626.3	Q14592	ZN460_HUMAN	zinc finger protein 460	31	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GGGGCAGTTGGACGTGACCCA	0.542000													17	97					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39468069	39468069	+	Silent	SNP	T	T	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr8:39468069T>C	ENST00000265707.5	+	6	411	c.366T>C	c.(364-366)aaT>aaC	p.N122N	ADAM18_ENST00000379866.1_Silent_p.N122N|ADAM18_ENST00000520772.1_Silent_p.N122N|ADAM18_ENST00000541111.1_Intron	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	122					cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			AGTTTGAAAATATCAGTTATG	0.289000													6	51					0	0	1	0	0
OR56B4	196335	broad.mit.edu	37	11	6129507	6129507	+	Missense_Mutation	SNP	A	A	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:6129507A>T	ENST00000316529.3	+	1	594	c.499A>T	c.(499-501)Ata>Tta	p.I167L	RP11-290F24.3_ENST00000529961.1_RNA	NM_001005181.1	NP_001005181.1	Q8NH76	O56B4_HUMAN	olfactory receptor, family 56, subfamily B, member 4	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|lung(10)|skin(6)|urinary_tract(2)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.31e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCCAGTGCCTATACTGGCTGC	0.507000													30	58					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70482166	70482166	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:70482166C>A	ENST00000310961.5	+	15	1588	c.1170C>A	c.(1168-1170)ttC>ttA	p.F390L	LRRC7_ENST00000415775.2_5'UTR|LRRC7_ENST00000035383.5_Missense_Mutation_p.F385L|RP11-181B18.1_ENST00000414132.1_RNA			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	385						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						ATTTACCATTCTCATTTACCA	0.289000													8	77					5.4927e-09	7.45354e-09	1	1	0
NUDT17	200035	broad.mit.edu	37	1	145587764	145587764	+	Silent	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:145587764G>A	ENST00000334513.5	-	5	561	c.550C>T	c.(550-552)Ctg>Ttg	p.L184L	NUDT17_ENST00000444015.2_5'UTR	NM_001012758.2	NP_001012776.1	P0C025	NUD17_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 17	184	Nudix hydrolase.						hydrolase activity|metal ion binding			endometrium(3)|large_intestine(1)|lung(2)|skin(1)|urinary_tract(2)	9	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					AGTAGATACAGAACAATGTGA	0.502000													3	11					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41149378	41149378	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:41149378C>G	ENST00000263413.3	-	17	2852	c.2588G>C	c.(2587-2589)gGc>gCc	p.G863A	C6_ENST00000337836.5_Missense_Mutation_p.G863A	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	863	C5b-binding domain.|Complement control factor I module 2.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				GGTGTCATAGCCACAGGATTC	0.433000													16	149					0	0	1	0	0
NMU	10874	broad.mit.edu	37	4	56496622	56496622	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr4:56496622G>C	ENST00000264218.3	-	2	223	c.118C>G	c.(118-120)Cca>Gca	p.P40A	NMU_ENST00000505262.1_Missense_Mutation_p.P40A|NMU_ENST00000507338.1_Missense_Mutation_p.P40A|NMU_ENST00000511469.1_Missense_Mutation_p.P40A|NMU_ENST00000515325.1_5'UTR	NM_006681.2	NP_006672.1	P48645	NMU_HUMAN	neuromedin U	40					neuropeptide signaling pathway	extracellular region				lung(3)|ovary(1)|urinary_tract(1)	5	Lung NSC(11;0.00256)|all_epithelial(27;0.075)|Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.103)	LUSC - Lung squamous cell carcinoma(4;6.72e-08)|Lung(4;6.22e-07)|Epithelial(7;0.00559)	LUSC - Lung squamous cell carcinoma(721;0.0115)		GGTAATATTGGAGCACCTAAA	0.318000													8	68					0	0	1	0	0
BCL11A	53335	broad.mit.edu	37	2	60687732	60687732	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:60687732C>T	ENST00000335712.6	-	4	2542	c.2315G>A	c.(2314-2316)tGc>tAc	p.C772Y	BCL11A_ENST00000538214.1_Missense_Mutation_p.C738Y|BCL11A_ENST00000356842.4_Intron|BCL11A_ENST00000358510.4_Missense_Mutation_p.C738Y|BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000359629.5_Intron|BCL11A_ENST00000537768.1_Intron	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	772					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			GCACAGCTCGCATTTATAAGG	0.502000			T	IGH@	B-CLL								5	93					0	0	1	0	0
PRPF6	24148	broad.mit.edu	37	20	62616366	62616366	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr20:62616366G>C	ENST00000535781.1	+	3	458	c.347G>C	c.(346-348)aGa>aCa	p.R116T	ZNF512B_ENST00000217130.3_Intron|ZNF512B_ENST00000450537.1_Intron			O94906	PRP6_HUMAN	pre-mRNA processing factor 6	116					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					GATGAAAGAAGAAAAGAAAGA	0.428000													7	55					0	0	1	0	0
KAT6A	7994	broad.mit.edu	37	8	41832305	41832305	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr8:41832305C>T	ENST00000396930.3	-	9	1942	c.1399G>A	c.(1399-1401)Gag>Aag	p.E467K	KAT6A_ENST00000265713.2_Missense_Mutation_p.E467K|KAT6A_ENST00000485568.1_Missense_Mutation_p.E467K|KAT6A_ENST00000406337.1_Missense_Mutation_p.E467K	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	467	Interaction with RUNX1-1.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										AGTCGCTCCTCATTTTCTTGT	0.373000													17	30					0	0	1	0	0
CCDC19	25790	broad.mit.edu	37	1	159847251	159847251	+	Splice_Site	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:159847251G>C	ENST00000426543.2	-	9	1246	c.791C>G	c.(790-792)gCt>gGt	p.A264G	CCDC19_ENST00000476696.1_5'UTR|CCDC19_ENST00000368099.4_Splice_Site_p.A349G			Q9UL16	CCD19_HUMAN	coiled-coil domain containing 19	349						mitochondrion|soluble fraction				endometrium(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	26	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			TGCTTCTCGAGCCTGCCGGAA	0.532000													8	79					0	0	1	0	0
HECTD3	79654	broad.mit.edu	37	1	45475299	45475299	+	Silent	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:45475299G>A	ENST00000372172.4	-	5	887	c.816C>T	c.(814-816)agC>agT	p.S272S		NM_024602.5	NP_078878.3	Q5T447	HECD3_HUMAN	HECT domain containing E3 ubiquitin protein ligase 3	272	DOC.				proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	ubiquitin-protein ligase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|stomach(1)	28	Acute lymphoblastic leukemia(166;0.155)					GGGACCCATCGCTCTCCCAGT	0.577000													6	54					0	0	1	0	0
SLC2A10	81031	broad.mit.edu	37	20	45354596	45354596	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr20:45354596G>T	ENST00000359271.2	+	2	1171	c.921G>T	c.(919-921)atG>atT	p.M307I		NM_030777.3	NP_110404.1	O95528	GTR10_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 10	307						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	34		Myeloproliferative disorder(115;0.0122)				GTGCCCTCATGGCCCTGTCCG	0.667000													5	45					0.00198382	0.00223934	1	1	0
ANO9	338440	broad.mit.edu	37	11	418925	418925	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:418925C>T	ENST00000332826.6	-	21	2083	c.1999G>A	c.(1999-2001)Gat>Aat	p.D667N		NM_001012302.2	NP_001012302	A1A5B4	ANO9_HUMAN	anoctamin 9	667						chloride channel complex	chloride channel activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|lung(5)|ovary(1)|prostate(4)|skin(4)	21						TCAATCCCATCAGGGTCCTGG	0.592000													15	140					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156821165	156821165	+	Silent	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:156821165G>C	ENST00000368195.3	-	5	1542	c.1146C>G	c.(1144-1146)ctC>ctG	p.L382L	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	382					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GCTTGATTTTGAGGAAGCCAG	0.547000													11	95					0	0	1	0	0
A2ML1	144568	broad.mit.edu	37	12	9004433	9004433	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:9004433G>C	ENST00000299698.7	+	19	2468	c.2288G>C	c.(2287-2289)tGg>tCg	p.W763S	A2ML1_ENST00000539547.1_Missense_Mutation_p.W272S	NM_001282424.1|NM_144670.4	NP_001269353.1|NP_653271	B3KVV6	B3KVV6_HUMAN	alpha-2-macroglobulin-like 1	607						extracellular space	endopeptidase inhibitor activity			NS(2)|breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(2)|lung(36)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	80						ATCACCGAGTGGAAGGCGATG	0.542000													6	29					0	0	1	0	0
TOMM70A	9868	broad.mit.edu	37	3	100100544	100100544	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:100100544C>T	ENST00000284320.5	-	5	1247	c.799G>A	c.(799-801)Gat>Aat	p.D267N		NM_014820.4	NP_055635.3	O94826	TOM70_HUMAN	translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)	267					protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	protein binding|protein transmembrane transporter activity			endometrium(11)|large_intestine(5)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	32						GAAATGATATCATCCGTGAAA	0.388000													6	66					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151167032	151167032	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:151167032T>C	ENST00000282466.3	-	4	736	c.737A>G	c.(736-738)gAt>gGt	p.D246G		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	246	LRRCT.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GGGACTTCTATCTTTTTTGCA	0.383000													9	67					0	0	1	0	0
KRT14	3861	broad.mit.edu	37	17	39740552	39740552	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:39740552C>A	ENST00000167586.6	-	3	808	c.722G>T	c.(721-723)aGc>aTc	p.S241I		NM_000526.4	NP_000517	P02533	K1C14_HUMAN	keratin 14	241	Coil 1B.|Rod.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(3)|lung(7)|ovary(1)|prostate(5)|skin(1)|stomach(1)	25		Breast(137;0.000307)				CTCCTTCAGGCTCTCAATCTG	0.542000													16	85					4.7546e-09	6.47982e-09	1	1	0
MRPL23	6150	broad.mit.edu	37	11	1972204	1972204	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:1972204C>T	ENST00000381514.3	+	2	115	c.93C>T	c.(91-93)ccC>ccT	p.P31P	MRPL23_ENST00000381519.1_Silent_p.P31P|MRPL23_ENST00000397298.3_Silent_p.P31P|MRPL23_ENST00000486931.1_3'UTR|MRPL23_ENST00000397294.3_Silent_p.P31P|MRPL23_ENST00000397297.3_Silent_p.P31P			Q16540	RM23_HUMAN	mitochondrial ribosomal protein L23	31					translation	mitochondrial large ribosomal subunit	nucleotide binding|RNA binding|structural constituent of ribosome			large_intestine(2)|lung(1)|ovary(1)	4		all_epithelial(84;6.24e-05)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.0026)|Lung(200;0.0171)|LUSC - Lung squamous cell carcinoma(625;0.0842)		TGGTGCGGCCCGGTGTGGCCC	0.642000													10	6					0	0	1	0	0
LOC150776	150776	broad.mit.edu	37	2	132273177	132273177	+	RNA	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:132273177G>T	ENST00000438378.2	+	0	1237					NR_026922.1																						CCACCCAGGAGTCGTTCACGC	0.642000													4	9					0.217242	0.22074	1	1	0
SPRYD3	84926	broad.mit.edu	37	12	53471023	53471023	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:53471023C>T	ENST00000301463.4	-	2	132	c.46G>A	c.(46-48)Gat>Aat	p.D16N	SPRYD3_ENST00000547837.1_Missense_Mutation_p.D53N	NM_032840.2	NP_116229.1	Q8NCJ5	SPRY3_HUMAN	SPRY domain containing 3	16										central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	17						TTGAGGTCATCCATCTTGTTC	0.532000													3	35					0	0	1	0	0
TRIM9	114088	broad.mit.edu	37	14	51561050	51561050	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr14:51561050G>T	ENST00000298355.3	-	1	1729	c.608C>A	c.(607-609)cCc>cAc	p.P203H	TRIM9_ENST00000338969.5_Missense_Mutation_p.P203H|TRIM9_ENST00000360392.4_Missense_Mutation_p.P203H	NM_015163.5	NP_055978.4	Q9C026	TRIM9_HUMAN	tripartite motif containing 9	203					proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_epithelial(31;0.00418)|Breast(41;0.148)					CTTGGCTAGGGGCCCCCGGGG	0.687000													3	32					0.00024832	0.000293427	1	1	0
MTHFD1L	25902	broad.mit.edu	37	6	151334931	151334931	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr6:151334931C>A	ENST00000367321.3	+	22	2556	c.2282C>A	c.(2281-2283)cCt>cAt	p.P761H		NM_001242767.1|NM_001242768.1|NM_015440.4	NP_001229696.1|NP_001229697.1|NP_056255.2	Q6UB35	C1TM_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	761	Formyltetrahydrofolate synthetase.				folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(8)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	29		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		GCTGGTGTTCCTCTTAAGAAA	0.373000													6	94					8.12818e-05	9.75073e-05	1	1	0
CDH4	1002	broad.mit.edu	37	20	60504806	60504806	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr20:60504806C>A	ENST00000360469.5	+	13	2233	c.2145C>A	c.(2143-2145)gaC>gaA	p.D715E	CDH4_ENST00000543233.1_Missense_Mutation_p.D641E	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	715	Cadherin 5.				adherens junction organization|cell junction assembly		calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			CATGTGATGACAACGGGGACT	0.587000													6	34					5.9392e-07	7.75908e-07	1	1	0
TCHHL1	126637	broad.mit.edu	37	1	152058614	152058614	+	Missense_Mutation	SNP	C	C	A	rs151016610		TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:152058614C>A	ENST00000368806.1	-	3	1608	c.1544G>T	c.(1543-1545)aGg>aTg	p.R515M		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	515							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			CTTGGTGACCCTAGTATTTTC	0.498000													12	84					1.08611e-07	1.44585e-07	1	1	0
DNAJC15	29103	broad.mit.edu	37	13	43652820	43652820	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr13:43652820G>T	ENST00000379221.2	+	4	731	c.307G>T	c.(307-309)Gta>Tta	p.V103L	DNAJC15_ENST00000474320.1_3'UTR	NM_013238.2	NP_037370.2	Q9Y5T4	DJC15_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 15	103	J.					integral to membrane	heat shock protein binding			endometrium(2)|kidney(1)|urinary_tract(1)	4		Lung NSC(96;4.3e-06)|Breast(139;0.00869)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		GBM - Glioblastoma multiforme(144;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0737)		TATTTTAGGTGTAAGGTAGGT	0.348000													6	39					5.68852e-11	7.92375e-11	1	1	0
SORL1	6653	broad.mit.edu	37	11	121391505	121391505	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:121391505G>T	ENST00000260197.7	+	9	1480	c.1351G>T	c.(1351-1353)Gag>Tag	p.E451*	SORL1_ENST00000532451.1_3'UTR	NM_003105.5	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	451					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GGGAACCTGGGAGTTTCTTCA	0.408000													14	34					4.3838e-07	5.76287e-07	1	1	0
LEPROT	54741	broad.mit.edu	37	1	65897510	65897510	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:65897510G>A	ENST00000371065.4	+	4	442	c.304G>A	c.(304-306)Gtg>Atg	p.V102M	LEPR_ENST00000406510.3_Intron|LEPR_ENST00000349533.6_Intron|LEPR_ENST00000371060.3_Intron|LEPR_ENST00000344610.8_Intron|LEPR_ENST00000371059.3_Intron	NM_001198681.1|NM_017526.4	NP_001185610.1|NP_059996.1	O15243	OBRG_HUMAN	leptin receptor overlapping transcript	102						endosome membrane|Golgi membrane|integral to plasma membrane				kidney(1)|large_intestine(1)|lung(5)	7				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		CTGCGGCCTTGTGTTGGCAGG	0.398000													3	43					0	0	1	0	0
EMR1	2015	broad.mit.edu	37	19	6926514	6926514	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:6926514C>T	ENST00000312053.4	+	16	2161	c.2124C>T	c.(2122-2124)atC>atT	p.I708I	EMR1_ENST00000450315.3_Silent_p.I531I|EMR1_ENST00000381407.5_Silent_p.I567I|EMR1_ENST00000250572.8_Silent_p.I643I|EMR1_ENST00000381404.4_Silent_p.I656I	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	708					cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					CTCGCAACATCAAGATGCTGC	0.507000													16	76					0	0	1	0	0
SLC9A3	6550	broad.mit.edu	37	5	477488	477488	+	Silent	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:477488C>A	ENST00000264938.3	-	11	1728	c.1719G>T	c.(1717-1719)acG>acT	p.T573T	CTD-2228K2.7_ENST00000607286.1_RNA|SLC9A3_ENST00000514375.1_Silent_p.T564T|CTD-2228K2.7_ENST00000607005.1_RNA|CTD-2228K2.7_ENST00000606288.1_RNA	NM_004174.2	NP_004165.2	P48764	SL9A3_HUMAN	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3	573						cell surface|integral to membrane	sodium:hydrogen antiporter activity			NS(2)|biliary_tract(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(16)|prostate(3)|skin(2)|urinary_tract(1)	37			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			ACGATCGTGGCGTGAAGTCCA	0.652000													5	23					0.0215528	0.0229339	1	1	0
OR5W2	390148	broad.mit.edu	37	11	55681365	55681365	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:55681365C>T	ENST00000344514.1	-	1	693	c.694G>A	c.(694-696)Gag>Aag	p.E232K		NM_001001960.1	NP_001001960.1	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W, member 2	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(28)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						AACCTCCCCTCAGCAGAGTGT	0.413000													4	39					0	0	1	0	0
NUP155	9631	broad.mit.edu	37	5	37350301	37350301	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:37350301G>T	ENST00000231498.3	-	7	993	c.790C>A	c.(790-792)Ctt>Att	p.L264I	NUP155_ENST00000381843.2_Missense_Mutation_p.L205I|NUP155_ENST00000513532.1_Missense_Mutation_p.L264I	NM_153485.1	NP_705618.1	O75694	NU155_HUMAN	nucleoporin 155kDa	264					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			endometrium(1)|kidney(16)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	62	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GAAGGAACAAGGAAAGAAAGT	0.358000													11	81					1.5739e-10	2.17791e-10	1	1	0
DOCK10	55619	broad.mit.edu	37	2	225659644	225659644	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:225659644C>G	ENST00000409592.3	-	45	5201	c.5088G>C	c.(5086-5088)tgG>tgC	p.W1696C	DOCK10_ENST00000258390.7_Missense_Mutation_p.W1702C			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1702	DHR-2.						GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		TACTTTCCAGCCAGGTCCTGC	0.502000													13	79					0	0	1	0	0
WASF3	10810	broad.mit.edu	37	13	27256894	27256894	+	Silent	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr13:27256894G>T	ENST00000361042.4	+	9	1350	c.1125G>T	c.(1123-1125)acG>acT	p.T375T	WASF3_ENST00000335327.5_Silent_p.T378T			Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	378					actin filament polymerization	cytoplasm|cytoskeleton	actin binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|pancreas(1)|prostate(2)|skin(2)	22	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		CCAGCTCCACGCACGCAGCTC	0.701000													3	29					1	1	1	1	0
ANKRD30A	91074	broad.mit.edu	37	10	37490186	37490186	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr10:37490186G>C	ENST00000374660.1	+	37	3090	c.2991G>C	c.(2989-2991)caG>caC	p.Q997H	ANKRD30A_ENST00000602533.1_Missense_Mutation_p.Q878H|ANKRD30A_ENST00000361713.1_Missense_Mutation_p.Q878H			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1023						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						CTGTTTCACAGAAGGATGTGT	0.289000													5	57					0	0	1	0	0
SYTL1	84958	broad.mit.edu	37	1	27676943	27676943	+	Silent	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:27676943G>A	ENST00000543823.1	+	9	1434	c.972G>A	c.(970-972)cgG>cgA	p.R324R	SYTL1_ENST00000490170.1_3'UTR|SYTL1_ENST00000318074.5_Silent_p.R312R			Q8IYJ3	SYTL1_HUMAN	synaptotagmin-like 1	324	C2 1.				exocytosis|intracellular protein transport	extrinsic to plasma membrane|melanosome|soluble fraction	neurexin binding|Rab GTPase binding			NS(1)|large_intestine(4)|lung(5)|ovary(1)|urinary_tract(1)	12		Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.0115)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0908)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-28)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.0013)|KIRC - Kidney renal clear cell carcinoma(1967;0.00158)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		TGAAGAAACGGAATCTGAATC	0.597000													3	35					0	0	1	0	0
REG1B	5968	broad.mit.edu	37	2	79313604	79313604	+	Silent	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:79313604G>T	ENST00000305089.3	-	4	290	c.210C>A	c.(208-210)ggC>ggA	p.G70G		NM_006507.3	NP_006498.1	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta	70	C-type lectin.				cell proliferation	extracellular region	sugar binding			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(40)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	51						ACACCAGGTTGCCTGAATTCA	0.517000													6	67					8.12818e-05	9.75073e-05	1	1	0
SALL2	6297	broad.mit.edu	37	14	21993304	21993304	+	Silent	SNP	T	T	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr14:21993304T>C	ENST00000327430.3	-	2	852	c.558A>G	c.(556-558)ctA>ctG	p.L186L	SALL2_ENST00000450879.2_Intron|SALL2_ENST00000538754.1_Intron|SALL2_ENST00000317492.5_Intron	NM_005407.1	NP_005398.1	Q9Y467	SALL2_HUMAN	spalt-like transcription factor 2	186							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		GCAGCACCCGTAGCTCTTCCA	0.622000													5	28					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82833929	82833929	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:82833929A>G	ENST00000265077.3	+	8	5672	c.5107A>G	c.(5107-5109)Acc>Gcc	p.T1703A	VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000342785.4_Intron|VCAN_ENST00000512590.2_Intron|VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000343200.5_Missense_Mutation_p.T716A	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	1703	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		AGTGGTGCCTACCAAGTTTGT	0.433000													6	63					0	0	1	0	0
ZFX	7543	broad.mit.edu	37	X	24197517	24197517	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:24197517C>T	ENST00000379177.1	+	6	703	c.276C>T	c.(274-276)atC>atT	p.I92I	ZFX_ENST00000338565.3_Silent_p.I92I|ZFX_ENST00000379188.3_Silent_p.I92I|ZFX_ENST00000459724.1_Intron|ZFX_ENST00000539115.1_Intron|ZFX_ENST00000540034.1_Silent_p.I131I|ZFX_ENST00000304543.5_Silent_p.I92I	NM_001178085.1|NM_003410.3	NP_001171556.1|NP_003401.2	P17010	ZFX_HUMAN	zinc finger protein, X-linked	92					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(2)|lung(4)|ovary(2)|prostate(1)	24						AAACGGTCATCATTCCTGAGC	0.413000													7	181					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240370691	240370691	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:240370691C>A	ENST00000319653.9	+	5	2809	c.2579C>A	c.(2578-2580)cCt>cAt	p.P860H		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	860	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TCTCCACCACCTCTGCCTTGC	0.567000													10	43					1.08611e-07	1.44585e-07	1	1	0
TDGF1	6997	broad.mit.edu	37	3	46620775	46620775	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:46620775G>A	ENST00000296145.5	+	3	875	c.142G>A	c.(142-144)Gat>Aat	p.D48N	TDGF1_ENST00000542931.1_Missense_Mutation_p.D32N|LRRC2_ENST00000296144.3_Intron	NM_003212.3	NP_003203.1	P13385	TDGF1_HUMAN	teratocarcinoma-derived growth factor 1	48					activation of MAPK activity|anterior/posterior axis specification, embryo|mammary gland development|morphogenesis of a branching structure|negative regulation of apoptosis|peptidyl-serine phosphorylation|positive regulation of cell migration|positive regulation of peptidyl-tyrosine phosphorylation	anchored to membrane|cell surface|extrinsic to plasma membrane	growth factor activity			cervix(2)|endometrium(1)|kidney(1)|lung(4)	8				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0173)|Kidney(197;0.0204)		GGCCTTCAGAGATGACAGCAT	0.532000													4	37					0	0	1	0	0
NECAB1	64168	broad.mit.edu	37	8	91963371	91963371	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr8:91963371C>A	ENST00000417640.2	+	12	1306	c.969C>A	c.(967-969)ttC>ttA	p.F323L	NECAB1_ENST00000522820.1_Missense_Mutation_p.F72L|NECAB1_ENST00000521366.1_Missense_Mutation_p.F72L	NM_022351.4	NP_071746.1	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	323					antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(7)	12			BRCA - Breast invasive adenocarcinoma(11;0.0499)			GCAAGACATTCCAAAGAAGTA	0.363000													3	29					0.150653	0.155077	1	1	0
ZNF699	374879	broad.mit.edu	37	19	9406818	9406818	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:9406818C>A	ENST00000591998.1	-	6	1490	c.1262G>T	c.(1261-1263)tGt>tTt	p.C421F	ZNF699_ENST00000308650.3_Missense_Mutation_p.C421F			Q32M78	ZN699_HUMAN	zinc finger protein 699	421					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						ACATTCCAGACATTCATACGG	0.408000													10	53					4.68919e-08	6.32239e-08	1	1	0
CDC27	996	broad.mit.edu	37	17	45209694	45209694	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:45209694C>A	ENST00000066544.3	-	15	2053	c.1960G>T	c.(1960-1962)Gca>Tca	p.A654S	CDC27_ENST00000531206.1_Missense_Mutation_p.A660S|CDC27_ENST00000527547.1_Missense_Mutation_p.A653S|CDC27_ENST00000446365.2_Missense_Mutation_p.A593S	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	654					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						TGCATTTCTGCAAGGCTGAAT	0.299000													7	53					0.00198382	0.00223934	1	1	0
OR5W2	390148	broad.mit.edu	37	11	55681240	55681240	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:55681240C>A	ENST00000344514.1	-	1	818	c.819G>T	c.(817-819)atG>atT	p.M273I		NM_001001960.1	NP_001001960.1	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W, member 2	273					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(28)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						ACAATGAGGTCATTTTATCTT	0.418000													5	29					0.184627	0.188511	1	1	0
FITM1	161247	broad.mit.edu	37	14	24601573	24601573	+	Silent	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr14:24601573G>T	ENST00000267426.5	+	2	709	c.420G>T	c.(418-420)cgG>cgT	p.R140R	FITM1_ENST00000559294.1_5'UTR	NM_203402.2	NP_981947.1	A5D6W6	FITM1_HUMAN	fat storage-inducing transmembrane protein 1	140					lipid particle organization|positive regulation of sequestering of triglyceride	endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	11						GAGCCGGCCGGGCCTTCCTGC	0.677000													3	27					2.56e-06	3.28994e-06	1	1	0
OSBP	5007	broad.mit.edu	37	11	59344368	59344368	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:59344368C>A	ENST00000263847.1	-	13	2670	c.2191G>T	c.(2191-2193)Gaa>Taa	p.E731*		NM_002556.2	NP_002547.1	P22059	OSBP1_HUMAN	oxysterol binding protein	731					lipid transport	Golgi membrane	oxysterol binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		GCATTTGCTTCATCCCAGCGT	0.507000													26	117					2.79863e-10	3.84736e-10	1	1	0
CRB1	23418	broad.mit.edu	37	1	197390138	197390138	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:197390138T>C	ENST00000367400.3	+	6	1315	c.1180T>C	c.(1180-1182)Tgc>Cgc	p.C394R	CRB1_ENST00000367397.1_5'UTR|CRB1_ENST00000367399.2_Missense_Mutation_p.C282R|CRB1_ENST00000476483.1_3'UTR|CRB1_ENST00000538660.1_Missense_Mutation_p.C394R|CRB1_ENST00000544212.1_5'UTR|CRB1_ENST00000535699.1_Missense_Mutation_p.C325R|CRB1_ENST00000543483.1_Missense_Mutation_p.C93R	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	394	EGF-like 9.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						AGGAATCCACTGCGAAGAAGA	0.343000													10	84					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123419183	123419183	+	Silent	SNP	G	G	A	rs58176285		TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:123419183G>A	ENST00000360772.3	-	19	3510	c.3132C>T	c.(3130-3132)gcC>gcT	p.A1044A	MYLK_ENST00000359169.1_Silent_p.A1044A|MYLK_ENST00000475616.1_Silent_p.A1044A|MYLK_ENST00000346322.5_Silent_p.A975A|MYLK_ENST00000360304.3_Silent_p.A1044A			Q15746	MYLK_HUMAN	myosin light chain kinase	1044	6 X 12 AA approximate tandem repeats.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity	p.A1044A(1)		NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		TCAGGGTCTCGGCAGGCTTGG	0.552000													9	141					0	0	1	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202603	140202603	+	Missense_Mutation	SNP	G	G	A	rs145876105		TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:140202603G>A	ENST00000529859.1	+	1	1243	c.1243G>A	c.(1243-1245)Gag>Aag	p.E415K	PCDHA3_ENST00000522353.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000378126.3_Missense_Mutation_p.E415K|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Missense_Mutation_p.E415K|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTGGACCGCGAGAGCGTGTC	0.642000													14	120					0	0	1	0	0
KLRF1	51348	broad.mit.edu	37	12	9994985	9994985	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:9994985G>C	ENST00000279544.3	+	5	607	c.543G>C	c.(541-543)ttG>ttC	p.L181F	KLRF1_ENST00000537723.1_Intron|KLRF1_ENST00000354855.3_Intron|KLRF1_ENST00000324214.4_Missense_Mutation_p.L131F	NM_016523.1	NP_057607	Q9NZS2	KLRF1_HUMAN	killer cell lectin-like receptor subfamily F, member 1	181	C-type lectin.				cell surface receptor linked signaling pathway	integral to plasma membrane	MHC class I receptor activity|sugar binding			breast(1)|endometrium(2)|large_intestine(4)|lung(6)	13						TTACCTCCTTGAAAATGACAT	0.338000													4	40					0	0	1	0	0
UBR5	51366	broad.mit.edu	37	8	103301731	103301731	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr8:103301731G>A	ENST00000520539.1	-	35	5269	c.4663C>T	c.(4663-4665)Cgg>Tgg	p.R1555W	UBR5_ENST00000220959.4_Missense_Mutation_p.R1555W|UBR5_ENST00000519528.1_Intron|UBR5_ENST00000521922.1_Missense_Mutation_p.R1549W	NM_001282873.1|NM_015902.5	NP_001269802.1|NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	1555					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TCTCTGCCCCGAACGGGCTGT	0.423000													7	35					0	0	1	0	0
AIMP2	7965	broad.mit.edu	37	7	6054921	6054921	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:6054921C>T	ENST00000223029.3	+	2	399	c.280C>T	c.(280-282)Caa>Taa	p.Q94*	AIMP2_ENST00000395236.2_Intron|AIMP2_ENST00000400479.2_Nonsense_Mutation_p.Q16*	NM_006303.3	NP_006294.2	Q13155	AIMP2_HUMAN	aminoacyl tRNA synthetase complex-interacting multifunctional protein 2	94	Interaction with PARK2.				apoptosis|cell differentiation|multicellular organismal development|tRNA aminoacylation for protein translation	cytosol|nucleus	protein binding			large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	13						CAACATAATCCAAGCGGATGA	0.433000													9	117					0	0	1	0	0
ZNF253	56242	broad.mit.edu	37	19	19990898	19990898	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:19990898G>A	ENST00000589717.1	+	3	261	c.169G>A	c.(169-171)Gag>Aag	p.E57K	ZNF253_ENST00000355650.4_Intron	NM_021047.2	NP_066385.2	O75346	ZN253_HUMAN	zinc finger protein 253	57	KRAB.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(6)|lung(11)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TACCTGTCTGGAGCAAGGAAA	0.373000													8	70					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123419159	123419159	+	Silent	SNP	A	A	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:123419159A>G	ENST00000360772.3	-	19	3534	c.3156T>C	c.(3154-3156)aaT>aaC	p.N1052N	MYLK_ENST00000359169.1_Silent_p.N1052N|MYLK_ENST00000475616.1_Silent_p.N1052N|MYLK_ENST00000346322.5_Silent_p.N983N|MYLK_ENST00000360304.3_Silent_p.N1052N			Q15746	MYLK_HUMAN	myosin light chain kinase	1052	6 X 12 AA approximate tandem repeats.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CAGGCTTGGCATTGCCCATGG	0.552000													18	170					0	0	1	0	0
TNS3	64759	broad.mit.edu	37	7	47342587	47342587	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:47342587C>A	ENST00000398879.1	-	22	3784	c.3418G>T	c.(3418-3420)Gac>Tac	p.D1140Y	TNS3_ENST00000311160.9_Missense_Mutation_p.D1140Y|TNS3_ENST00000355730.3_Missense_Mutation_p.D900Y			Q68CZ2	TENS3_HUMAN	tensin 3	1140						focal adhesion	protein binding	p.D1140N(1)		NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						TTGGAAAAGTCGGGAAGGACA	0.597000													9	66					3.86212e-05	4.73203e-05	1	1	0
DST	667	broad.mit.edu	37	6	56467765	56467765	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr6:56467765G>A	ENST00000370754.5	-	42	11122	c.11123C>T	c.(11122-11124)tCa>tTa	p.S3708L	DST_ENST00000421834.2_Intron|DST_ENST00000361203.3_Missense_Mutation_p.S3530L|DST_ENST00000370788.2_Intron|DST_ENST00000312431.6_Missense_Mutation_p.S3530L|DST_ENST00000244364.6_Intron|DST_ENST00000370769.4_Missense_Mutation_p.S3530L|DST_ENST00000446842.2_Missense_Mutation_p.S3204L			Q03001	DYST_HUMAN	dystonin	3530					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GCTCTTCTCTGATACCCAATC	0.343000													9	35					0	0	1	0	0
SLMO2	51012	broad.mit.edu	37	20	57613582	57613582	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr20:57613582C>T	ENST00000355937.4	-	2	318	c.140G>A	c.(139-141)gGa>gAa	p.G47E	SLMO2_ENST00000371033.5_Missense_Mutation_p.G47E	NM_016045.2	NP_057129.2	Q9Y3B1	SLMO2_HUMAN	slowmo homolog 2 (Drosophila)	47	PRELI/MSF1.									endometrium(1)|lung(2)|skin(2)	5	all_lung(29;0.00711)		Colorectal(105;0.109)			GTGCAACTTTCCAGAGGGATC	0.468000													18	102					0	0	1	0	0
DDC	1644	broad.mit.edu	37	7	50537776	50537776	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:50537776G>T	ENST00000444124.2	-	12	1335	c.1135C>A	c.(1135-1137)Cgc>Agc	p.R379S	DDC_ENST00000357936.5_Missense_Mutation_p.R379S|DDC_ENST00000431062.1_Missense_Mutation_p.R286S|DDC_ENST00000426377.1_Missense_Mutation_p.R301S	NM_001082971.1	NP_001076440	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid decarboxylase)	379					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding	p.R379S(1)		breast(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(23)|ovary(4)|skin(2)|stomach(1)	40	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	GTCACCTTGCGGATATAAGCC	0.343000													7	64					0.00448238	0.00501486	1	1	0
GUCA2B	2981	broad.mit.edu	37	1	42621249	42621249	+	Silent	SNP	G	G	A	rs148865510	byFrequency	TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:42621249G>A	ENST00000372581.1	+	3	351	c.321G>A	c.(319-321)gcG>gcA	p.A107A		NM_007102.2	NP_009033.1	Q16661	GUC2B_HUMAN	guanylate cyclase activator 2B (uroguanylin)	107					excretion	extracellular region	calcium sensitive guanylate cyclase activator activity			breast(1)|large_intestine(2)	3	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TGAACGTTGCGTGTACCGGCT	0.632000													5	30					0	0	1	0	0
DNAAF3	352909	broad.mit.edu	37	19	55670711	55670711	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:55670711C>A	ENST00000527223.2	-	12	1547	c.1546G>T	c.(1546-1548)Gag>Tag	p.E516*	DNAAF3_ENST00000524407.2_Nonsense_Mutation_p.E449*|CTD-2587H24.4_ENST00000587871.1_Missense_Mutation_p.R110I|DNAAF3_ENST00000587789.2_5'UTR|CTD-2587H24.5_ENST00000591665.1_RNA|DNAAF3_ENST00000391720.4_Nonsense_Mutation_p.E496*|DNAAF3_ENST00000455045.1_Nonsense_Mutation_p.E395*	NM_001256714.1	NP_001243643	Q8N9W5	CS051_HUMAN	dynein, axonemal, assembly factor 3	449																	GCGAAGGTCTCTGAAGGCCTG	0.632000													8	24					0.0381472	0.0402523	1	1	0
SFXN5	94097	broad.mit.edu	37	2	73298774	73298774	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:73298774C>A	ENST00000272433.2	-	1	191	c.61G>T	c.(61-63)Gat>Tat	p.D21Y	SFXN5_ENST00000410065.1_Missense_Mutation_p.D21Y	NM_144579.2	NP_653180.1	Q8TD22	SFXN5_HUMAN	sideroflexin 5	21					iron ion homeostasis	integral to membrane	cation transmembrane transporter activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(1)|ovary(2)|prostate(1)	9						GGAGGTGCATCGCTCGAGGCG	0.642000													5	16					1.23904e-05	1.53602e-05	1	1	0
JUP	3728	broad.mit.edu	37	17	39777119	39777119	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:39777119C>G	ENST00000540235.1	-	9	1449	c.1450G>C	c.(1450-1452)Gag>Cag	p.E484Q	KRT17_ENST00000311208.8_Missense_Mutation_p.E325Q			P14923	PLAK_HUMAN	junction plakoglobin	0					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	23		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		AGGTTGCCCTCCAGGGATGCT	0.627000													5	48					0	0	1	0	0
BBS9	27241	broad.mit.edu	37	7	33313464	33313464	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:33313464G>C	ENST00000242067.6	+	9	1433	c.912G>C	c.(910-912)ttG>ttC	p.L304F	BBS9_ENST00000396127.2_Missense_Mutation_p.L304F|BBS9_ENST00000355070.2_Missense_Mutation_p.L304F|BBS9_ENST00000354265.4_Missense_Mutation_p.L304F|BBS9_ENST00000350941.3_Missense_Mutation_p.L304F|BBS9_ENST00000425508.2_Missense_Mutation_p.L259F	NM_198428.2	NP_940820.1	Q3SYG4	PTHB1_HUMAN	Bardet-Biedl syndrome 9	304					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding		BBS9/PKD1L1(2)	NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	50			GBM - Glioblastoma multiforme(11;0.0894)			TAAATACTTTGATTGGAAATC	0.358000									Bardet-Biedl syndrome				3	65					0	0	1	0	0
EP300	2033	broad.mit.edu	37	22	41536229	41536229	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr22:41536229G>T	ENST00000263253.7	+	9	3065	c.1846G>T	c.(1846-1848)Gaa>Taa	p.E616*		NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	616	KIX.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						TCGGAAAGTTGAAGGGGACAT	0.398000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				16	109					7.07596e-05	8.5864e-05	1	1	0
AHNAK	79026	broad.mit.edu	37	11	62289953	62289953	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:62289953C>A	ENST00000378024.4	-	5	12210	c.11936G>T	c.(11935-11937)gGt>gTt	p.G3979V	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	3979					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				CGCATCTGGACCTTCAATATT	0.488000													99	217					1.52783e-54	2.1762e-54	1	1	0
KCNV1	27012	broad.mit.edu	37	8	110980338	110980338	+	Silent	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr8:110980338C>A	ENST00000524391.1	-	4	2514	c.1482G>T	c.(1480-1482)ggG>ggT	p.G494G	KCNV1_ENST00000297404.1_Silent_p.G494G			Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	494						voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(20)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			AATCATCTCCCCCGCTGCTCC	0.373000													31	37					4.31634e-10	5.92089e-10	1	1	0
PFKFB1	5207	broad.mit.edu	37	X	54975594	54975594	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:54975594T>C	ENST00000375006.3	-	9	977	c.907A>G	c.(907-909)Acc>Gcc	p.T303A	PFKFB1_ENST00000374992.2_Intron|PFKFB1_ENST00000545676.1_Missense_Mutation_p.T238A	NM_002625.2	NP_002616.2	P16118	F261_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	303	Fructose-2,6-bisphosphatase.				energy reserve metabolic process|fructose 2,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|intracellular protein kinase cascade	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(11)|ovary(1)	24						ATGTGACTGGTCCACACCTTC	0.562000													9	20					0	0	1	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145806260	145806260	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr8:145806260G>T	ENST00000276826.5	-	2	683	c.482C>A	c.(481-483)gCg>gAg	p.A161E	ARHGAP39_ENST00000377307.2_Missense_Mutation_p.A161E|ARHGAP39_ENST00000540274.1_Missense_Mutation_p.A161E			Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	161					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						TGTCCCAAACGCCGCGGGCCG	0.706000													3	14					0.004672	0.00517199	1	1	0
EPS8L3	79574	broad.mit.edu	37	1	110301186	110301186	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:110301186C>T	ENST00000369805.3	-	7	793	c.564G>A	c.(562-564)ggG>ggA	p.G188G	EPS8L3_ENST00000361852.4_Silent_p.G187G|EPS8L3_ENST00000494151.1_5'UTR|EPS8L3_ENST00000361965.4_Silent_p.G187G|RP4-735C1.4_ENST00000431955.1_RNA	NM_139053.2	NP_620641.1	Q8TE67	ES8L3_HUMAN	EPS8-like 3	187	Pro-rich.					cytoplasm	protein binding			breast(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|skin(1)|upper_aerodigestive_tract(1)	32		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		CTGGAGGGATCCCCGGCTCCA	0.592000													6	48					0	0	1	0	0
XPO6	23214	broad.mit.edu	37	16	28187234	28187234	+	Missense_Mutation	SNP	A	A	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr16:28187234A>T	ENST00000304658.5	-	4	890	c.390T>A	c.(388-390)ttT>ttA	p.F130L	XPO6_ENST00000565698.1_Missense_Mutation_p.F116L	NM_015171.3	NP_055986.1	Q96QU8	XPO6_HUMAN	exportin 6	130					protein export from nucleus		protein binding|protein transporter activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	25						AAATGTTAGTAAAAAAGTCGT	0.363000													3	40					0	0	1	0	0
GBP4	115361	broad.mit.edu	37	1	89657165	89657165	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:89657165G>A	ENST00000355754.6	-	6	792	c.695C>T	c.(694-696)tCa>tTa	p.S232L		NM_052941.4	NP_443173.2	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	232						cytoplasm	GTP binding|GTPase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(19)|skin(1)|stomach(2)|urinary_tract(1)	33				all cancers(265;0.00723)|Epithelial(280;0.0291)		AGGCATGTTTGAATTTTGAAT	0.433000													4	48					0	0	1	0	0
OR52M1	119772	broad.mit.edu	37	11	4566768	4566768	+	Silent	SNP	C	C	A	rs147386851	byFrequency	TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:4566768C>A	ENST00000360213.1	+	1	348	c.348C>A	c.(346-348)atC>atA	p.I116I		NM_001004137.1	NP_001004137.1	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M, member 1	116					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(2)|lung(9)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGTCAGGCATCTTCCTTGCCA	0.517000													6	82					8.12818e-05	9.75073e-05	1	1	0
CCZ1B	221960	broad.mit.edu	37	7	6844602	6844602	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:6844602C>A	ENST00000316731.8	-	12	1645	c.1073G>T	c.(1072-1074)tGt>tTt	p.C358F	CCZ1B_ENST00000538180.1_Missense_Mutation_p.C215F	NM_198097.3	NP_932765.1	P86790	CCZ1L_HUMAN	CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)	358						lysosomal membrane											AAACTGTTCACAGATGTCAGA	0.478000													7	81					0.0293803	0.0312104	1	1	0
KPNA5	3841	broad.mit.edu	37	6	117023265	117023265	+	Silent	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr6:117023265G>A	ENST00000368564.1	+	6	667	c.519G>A	c.(517-519)ccG>ccA	p.P173P	KPNA5_ENST00000356348.1_Silent_p.P173P			O15131	IMA5_HUMAN	karyopherin alpha 5 (importin alpha 6)	170	NLS binding site (major) (By similarity).				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding|protein transporter activity	p.P173P(1)		breast(6)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0298)|all cancers(137;0.0461)|OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.212)		GGGCTGTTCCGATTTTTATCA	0.348000													4	69					0	0	1	0	0
TNFAIP8L1	126282	broad.mit.edu	37	19	4652055	4652055	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:4652055G>T	ENST00000536716.1	+	2	320	c.174G>T	c.(172-174)aaG>aaT	p.K58N	TNFAIP8L1_ENST00000327473.4_Missense_Mutation_p.K58N	NM_001167942.1	NP_001161414.1	Q8WVP5	TP8L1_HUMAN	tumor necrosis factor, alpha-induced protein 8-like 1	58										endometrium(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGCCCAGAAGATGCTCAAGA	0.667000													4	10					0.150653	0.155077	1	1	0
HOXA1	3198	broad.mit.edu	37	7	27135443	27135443	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:27135443G>C	ENST00000343060.4	-	1	150	c.89C>G	c.(88-90)tCg>tGg	p.S30W	HOTAIRM1_ENST00000495032.1_RNA|HOXA1_ENST00000355633.5_Missense_Mutation_p.S30W	NM_005522.4	NP_005513	P49639	HXA1_HUMAN	homeobox A1	30						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						CCTATGGTCCGAGGGGTAGGC	0.592000											OREG0003750	type=REGULATORY REGION|Gene=BC031342|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	14	62					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71495684	71495684	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:71495684G>C	ENST00000296755.7	+	5	6800	c.6502G>C	c.(6502-6504)Gag>Cag	p.E2168Q		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	2168						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		GGAGACTGAAGAGTGCCCCTC	0.567000													5	41					0	0	1	0	0
KIF24	347240	broad.mit.edu	37	9	34310980	34310980	+	Nonsense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr9:34310980G>C	ENST00000379166.2	-	2	484	c.365C>G	c.(364-366)tCa>tGa	p.S122*	KIF24_ENST00000379174.3_Nonsense_Mutation_p.S122*|KIF24_ENST00000345050.2_Nonsense_Mutation_p.S122*|KIF24_ENST00000402558.2_Nonsense_Mutation_p.S122*	NM_194313.2	NP_919289.2	Q5T7B8	KIF24_HUMAN	kinesin family member 24	122					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|liver(1)|lung(13)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	32			LUSC - Lung squamous cell carcinoma(29;0.0107)			AGAGAAATCTGATAAACTGCA	0.398000													3	99					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120475511	120475511	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr9:120475511G>T	ENST00000355622.6	+	3	1206	c.1105G>T	c.(1105-1107)Gaa>Taa	p.E369*	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Nonsense_Mutation_p.E329*	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	369					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						TGCTTTTTCAGAAGTTGATCT	0.378000													8	60					0.000274275	0.000320496	1	1	0
MTMR1	8776	broad.mit.edu	37	X	149895711	149895711	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:149895711C>A	ENST00000445323.2	+	5	498	c.377C>A	c.(376-378)cCa>cAa	p.P126Q	MTMR1_ENST00000370390.3_Missense_Mutation_p.P118Q|MTMR1_ENST00000451863.2_Missense_Mutation_p.P118Q|MTMR1_ENST00000541925.1_Missense_Mutation_p.P24Q|MTMR1_ENST00000538506.1_Missense_Mutation_p.P5Q|MTMR1_ENST00000542156.1_Missense_Mutation_p.P118Q|MTMR1_ENST00000544228.1_Missense_Mutation_p.P118Q			Q13613	MTMR1_HUMAN	myotubularin related protein 1	118	GRAM.					plasma membrane	protein tyrosine phosphatase activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(5)|ovary(2)|prostate(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					TATATCTGCCCATTTATGGGA	0.383000													8	54					1.06961e-07	1.43601e-07	1	1	0
CDH18	1016	broad.mit.edu	37	5	19839054	19839054	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:19839054C>T	ENST00000507958.1	-	5	1032	c.42G>A	c.(40-42)gtG>gtA	p.V14V	CDH18_ENST00000382275.1_Silent_p.V14V|CDH18_ENST00000511273.1_Silent_p.V14V|CDH18_ENST00000274170.4_Silent_p.V14V|CDH18_ENST00000502796.1_Silent_p.V14V|CDH18_ENST00000506372.1_Silent_p.V14V			Q13634	CAD18_HUMAN	cadherin 18, type 2	14					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					AACAGAGACACACTAGGACTG	0.428000													5	61					0	0	1	0	0
LRCH1	23143	broad.mit.edu	37	13	47303042	47303042	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr13:47303042G>C	ENST00000311191.6	+	17	2054	c.1825G>C	c.(1825-1827)Ggt>Cgt	p.G609R	LRCH1_ENST00000389798.3_Missense_Mutation_p.G609R|LRCH1_ENST00000389797.3_Missense_Mutation_p.G644R	NM_001164213.1	NP_001157685	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 1	609	CH.									breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		CCTCATGGATGGTGTCGTCCT	0.517000													6	34					0	0	1	0	0
FNDC3B	64778	broad.mit.edu	37	3	172046853	172046853	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:172046853G>A	ENST00000336824.4	+	12	1465	c.1366G>A	c.(1366-1368)Gac>Aac	p.D456N	FNDC3B_ENST00000415807.2_Missense_Mutation_p.D456N|FNDC3B_ENST00000416957.1_Missense_Mutation_p.D456N	NM_001135095.1	NP_001128567.1	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	456	Fibronectin type-III 2.					endoplasmic reticulum|integral to membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(26)|ovary(3)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	69	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		CGCTCGAAACGACATTGGTAC	0.512000													27	100					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84608242	84608242	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr9:84608242C>G	ENST00000344803.2	+	4	2904	c.2857C>G	c.(2857-2859)Cag>Gag	p.Q953E		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		CTTCATCTCTCAGGGAGATTC	0.483000													7	60					0	0	1	0	0
EBAG9	9166	broad.mit.edu	37	8	110575659	110575659	+	Silent	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr8:110575659C>A	ENST00000531677.1	+	6	555	c.555C>A	c.(553-555)ctC>ctA	p.L185L	EBAG9_ENST00000337573.5_Intron|EBAG9_ENST00000395785.2_Intron			O00559	RCAS1_HUMAN	estrogen receptor binding site associated, antigen, 9	174					apoptosis|regulation of cell growth	focal adhesion|Golgi membrane|integral to membrane|soluble fraction	apoptotic protease activator activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(2)	10			OV - Ovarian serous cystadenocarcinoma(57;1.39e-14)			TCTGCTCTCTCCTGTTTCATC	0.453000													109	149					2.68655e-49	3.81804e-49	1	1	0
BIN1	274	broad.mit.edu	37	2	127834239	127834239	+	Missense_Mutation	SNP	T	T	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:127834239T>G	ENST00000316724.5	-	2	539	c.128A>C	c.(127-129)cAg>cCg	p.Q43P	BIN1_ENST00000348750.4_Missense_Mutation_p.Q43P|BIN1_ENST00000352848.3_Missense_Mutation_p.Q43P|BIN1_ENST00000409400.1_Missense_Mutation_p.Q43P|BIN1_ENST00000259238.4_Missense_Mutation_p.Q43P|BIN1_ENST00000393040.3_Missense_Mutation_p.Q43P|BIN1_ENST00000393041.3_Missense_Mutation_p.Q43P|BIN1_ENST00000376113.2_Missense_Mutation_p.Q43P|BIN1_ENST00000357970.3_Missense_Mutation_p.Q43P|BIN1_ENST00000351659.3_Missense_Mutation_p.Q43P|BIN1_ENST00000346226.3_Missense_Mutation_p.Q43P	NM_139343.2	NP_647593.1	O00499	BIN1_HUMAN	bridging integrator 1	43	BAR.|Interaction with BIN2.				cell proliferation|endocytosis|interspecies interaction between organisms|multicellular organismal development	actin cytoskeleton|nucleus				NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(3)|skin(3)	24	Colorectal(110;0.0831)			BRCA - Breast invasive adenocarcinoma(221;0.073)		CTGCTCAAACTGCTCATCCTT	0.522000													15	67					0	0	1	0	0
UMOD	7369	broad.mit.edu	37	16	20359621	20359621	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr16:20359621C>T	ENST00000396134.2	-	5	1119	c.996G>A	c.(994-996)gaG>gaA	p.E332E	UMOD_ENST00000424589.1_Silent_p.E332E|UMOD_ENST00000396138.4_Silent_p.E348E|UMOD_ENST00000396142.2_Silent_p.E299E|UMOD_ENST00000570689.1_Silent_p.E299E|UMOD_ENST00000302509.4_Silent_p.E299E	NM_001278614.1	NP_001265543.1	P07911	UROM_HUMAN	uromodulin	299					cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			endometrium(5)|kidney(1)|large_intestine(7)|lung(20)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						CTATACTGCACTCCTCACACG	0.572000													19	94					0	0	1	0	0
BCL9L	283149	broad.mit.edu	37	11	118771569	118771569	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:118771569C>T	ENST00000334801.3	-	6	3847	c.2883G>A	c.(2881-2883)atG>atA	p.M961I	BCL9L_ENST00000526143.1_5'UTR	NM_182557.2	NP_872363.1	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	961	Pro-rich.				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		GCAAGGGCACCATCTGTGAGG	0.652000													3	27					0	0	1	0	0
CTSK	1513	broad.mit.edu	37	1	150776657	150776657	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:150776657T>C	ENST00000271651.3	-	5	568	c.458A>G	c.(457-459)aAg>aGg	p.K153R	CTSK_ENST00000480670.1_5'UTR	NM_000396.3	NP_000387.1	P43235	CATK_HUMAN	cathepsin K	153					proteolysis	lysosome	cysteine-type endopeptidase activity|protein binding			cervix(1)|endometrium(1)|lung(4)|skin(1)	7	all_cancers(9;2.32e-51)|all_epithelial(9;3.89e-42)|all_lung(15;4.59e-35)|Lung NSC(24;1.7e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Colorectal(459;0.171)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0485)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			AGTTTTCTTCTTGAGTTGGCC	0.483000													4	36					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48699772	48699772	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:48699772C>G	ENST00000544264.1	-	1	576	c.296G>C	c.(295-297)cGa>cCa	p.R99P	CELSR3_ENST00000164024.4_Missense_Mutation_p.R99P			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	99					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		AGGGGGCCCTCGACTATTCCG	0.667000													10	84					0	0	1	0	0
KLF5	688	broad.mit.edu	37	13	73636244	73636244	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr13:73636244C>A	ENST00000377687.4	+	2	1043	c.507C>A	c.(505-507)ttC>ttA	p.F169L	KLF5_ENST00000477333.1_3'UTR|KLF5_ENST00000539231.1_Missense_Mutation_p.F78L	NM_001730.3	NP_001721.2	Q13887	KLF5_HUMAN	Kruppel-like factor 5 (intestinal)	169					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		TTGCCATTTTCAGCCACCAGA	0.562000													3	33					1	1	1	1	0
GDPD1	284161	broad.mit.edu	37	17	57335173	57335173	+	Missense_Mutation	SNP	A	A	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:57335173A>T	ENST00000284116.4	+	6	685	c.548A>T	c.(547-549)tAt>tTt	p.Y183F	GDPD1_ENST00000581140.1_Missense_Mutation_p.Y183F|GDPD1_ENST00000581276.1_Missense_Mutation_p.Y183F	NM_182569.3	NP_872375.2	Q8N9F7	GDPD1_HUMAN	glycerophosphodiester phosphodiesterase domain containing 1	183	GDPD.				glycerol metabolic process|lipid metabolic process	cytoplasm|integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			endometrium(1)|kidney(1)|liver(1)|lung(2)|upper_aerodigestive_tract(1)	6	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					AATGCCAATTATGAAATTGTA	0.318000													12	45					0	0	1	0	0
FANCM	57697	broad.mit.edu	37	14	45644716	45644716	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr14:45644716C>G	ENST00000267430.5	+	14	2844	c.2759C>G	c.(2758-2760)cCg>cGg	p.P920R	FANCM_ENST00000542564.2_Missense_Mutation_p.P894R	NM_020937.2	NP_065988.1	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	920					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						ATTAAAGAACCGTGTGTGTTA	0.303000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				6	92					0	0	1	0	0
RTN3	10313	broad.mit.edu	37	11	63487795	63487795	+	Silent	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:63487795G>A	ENST00000377819.5	+	3	1975	c.1821G>A	c.(1819-1821)gaG>gaA	p.E607E	RTN3_ENST00000540798.1_Silent_p.E495E|RTN3_ENST00000354497.4_Intron|RTN3_ENST00000356000.3_Intron|RTN3_ENST00000339997.4_Silent_p.E588E|RTN3_ENST00000341307.2_Intron|RTN3_ENST00000537981.1_Intron	NM_001265589.1	NP_001252518.1	O95197	RTN3_HUMAN	reticulon 3	607					apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	20						TTACTACTGAGAACCCCAAAC	0.413000													10	72					0	0	1	0	0
TSNAXIP1	55815	broad.mit.edu	37	16	67860069	67860069	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr16:67860069G>T	ENST00000388833.3	+	10	1374	c.997G>T	c.(997-999)Ggc>Tgc	p.G333C	TSNAXIP1_ENST00000415766.3_Missense_Mutation_p.G318C|TSNAXIP1_ENST00000561639.1_Missense_Mutation_p.G387C	NM_018430.2	NP_060900.2	Q2TAA8	TXIP1_HUMAN	translin-associated factor X interacting protein 1	333					cell differentiation|multicellular organismal development|spermatogenesis	perinuclear region of cytoplasm				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(8)|prostate(1)|soft_tissue(1)|urinary_tract(1)	22		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00432)|Epithelial(162;0.0192)|all cancers(182;0.125)		GGTGGCTGGGGGCCCAGAGCG	0.642000													6	12					2.0095e-06	2.58774e-06	1	1	0
NEB	4703	broad.mit.edu	37	2	152536438	152536438	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:152536438G>C	ENST00000397345.3	-	31	3343	c.3141C>G	c.(3139-3141)atC>atG	p.I1047M	NEB_ENST00000409198.1_Missense_Mutation_p.I1047M|NEB_ENST00000172853.10_Missense_Mutation_p.I1047M|NEB_ENST00000427231.2_Missense_Mutation_p.I1047M|NEB_ENST00000603639.1_Missense_Mutation_p.I1047M|NEB_ENST00000604864.1_Missense_Mutation_p.I1047M	NM_001164508.1	NP_001157980	P20929	NEBU_HUMAN	nebulin	1047					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GCACCTCACTGATATTGTAGG	0.428000													5	36					0	0	1	0	0
GPN3	51184	broad.mit.edu	37	12	110891654	110891654	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:110891654C>A	ENST00000543199.1	-	7	887	c.803G>T	c.(802-804)cGa>cTa	p.R268L	GPN3_ENST00000537466.2_Missense_Mutation_p.R239L|GPN3_ENST00000228827.3_Missense_Mutation_p.R229L	NM_001164372.1	NP_001157844.1	Q9UHW5	GPN3_HUMAN	GPN-loop GTPase 3	229						protein complex	GTP binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|urinary_tract(1)	8						AGGTAAAAATCGAACCATGCT	0.313000													8	39					3.09899e-07	4.10811e-07	1	1	0
CHRNA2	1135	broad.mit.edu	37	8	27320812	27320812	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr8:27320812G>C	ENST00000407991.1	-	6	1756	c.1148C>G	c.(1147-1149)cCc>cGc	p.P383R	CHRNA2_ENST00000520933.2_Missense_Mutation_p.P383R|CHRNA2_ENST00000240132.2_Missense_Mutation_p.P368R	NM_000742.3	NP_000733.2	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha 2 (neuronal)	383						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine Iodide(DB00416)|Metocurine(DB01336)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	GGGTGGTGGGGGCCGGTTCAT	0.672000													7	23					0	0	1	0	0
RUVBL2	10856	broad.mit.edu	37	19	49513131	49513131	+	Silent	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:49513131C>A	ENST00000413176.2	+	7	1574	c.426C>A	c.(424-426)gtC>gtA	p.V142V	RUVBL2_ENST00000601968.1_Silent_p.V142V|RUVBL2_ENST00000595090.1_Silent_p.V187V			Q9Y230	RUVB2_HUMAN	RuvB-like AAA ATPase 2	187					cellular response to UV|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|protein folding|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|membrane|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|ATP-dependent DNA helicase activity|damaged DNA binding|identical protein binding|unfolded protein binding			large_intestine(1)|upper_aerodigestive_tract(1)	2		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000449)|OV - Ovarian serous cystadenocarcinoma(262;0.000555)|GBM - Glioblastoma multiforme(486;0.00585)|Epithelial(262;0.047)		AGGACAAGGTCCAGGCCGGGT	0.617000													6	50					8.12818e-05	9.75073e-05	1	1	0
CLCN4	1183	broad.mit.edu	37	X	10163105	10163105	+	Silent	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:10163105G>A	ENST00000380833.4	+	5	790	c.399G>A	c.(397-399)caG>caA	p.Q133Q	CLCN4_ENST00000380829.1_Silent_p.Q133Q|CLCN4_ENST00000421085.2_Silent_p.Q39Q	NM_001256944.1|NM_001830.3	NP_001243873.1|NP_001821.2	P51793	CLCN4_HUMAN	chloride channel, voltage-sensitive 4	133						early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						CCCTGTGGCAGAAATGGTCGG	0.572000													9	58					0	0	1	0	0
MSH2	4436	broad.mit.edu	37	2	47635645	47635645	+	Missense_Mutation	SNP	G	G	C	rs41295286		TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:47635645G>C	ENST00000406134.1	+	2	379	c.317G>C	c.(316-318)aGa>aCa	p.R106T	MSH2_ENST00000543555.1_Missense_Mutation_p.R40T|MSH2_ENST00000233146.2_Missense_Mutation_p.R106T			P43246	MSH2_HUMAN	mutS homolog 2	106			R -> K (in dbSNP:rs41295286).		B cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|double-strand break repair|intra-S DNA damage checkpoint|isotype switching|maintenance of DNA repeat elements|male gonad development|meiotic gene conversion|meiotic mismatch repair|negative regulation of neuron apoptosis|negative regulation of reciprocal meiotic recombination|positive regulation of helicase activity|postreplication repair|response to UV-B|response to X-ray|somatic hypermutation of immunoglobulin genes	MutSalpha complex|MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|guanine/thymine mispair binding|loop DNA binding|protein C-terminus binding|protein homodimerization activity|protein kinase binding|Y-form DNA binding	p.0?(2)|p.?(1)		NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(5)|large_intestine(50)|lung(18)|ovary(5)|prostate(2)|skin(3)|small_intestine(1)|stomach(2)|urinary_tract(1)	112		all_hematologic(82;0.0359)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TATAAGAATAGAGCTGGAAAT	0.289000			"""D, Mis, N, F, S"""		"""colorectal, endometrial, ovarian"""	"""colorectal, endometrial, ovarian"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				7	46					0	0	1	0	0
SLC27A1	376497	broad.mit.edu	37	19	17598006	17598006	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:17598006C>T	ENST00000252595.7	+	3	683	c.586C>T	c.(586-588)Ctg>Ttg	p.L196L	SLC27A1_ENST00000442725.1_Silent_p.L196L|SLC27A1_ENST00000598424.1_Silent_p.L17L	NM_198580.1	NP_940982.1	Q6PCB7	S27A1_HUMAN	solute carrier family 27 (fatty acid transporter), member 1	196	Sufficient for oligomerization (By similarity).				cardiolipin biosynthetic process|fatty acid metabolic process|long-chain fatty acid transport|negative regulation of phospholipid biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidylethanolamine biosynthetic process|phosphatidylinositol biosynthetic process|phosphatidylserine biosynthetic process|transmembrane transport	endomembrane system|integral to membrane	fatty acid transporter activity|nucleotide binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						GAGCGGGCATCTGGGGAAAAG	0.642000													3	29					0	0	1	0	0
HOXC10	3226	broad.mit.edu	37	12	54379266	54379266	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:54379266C>A	ENST00000303460.4	+	1	297	c.223C>A	c.(223-225)Cag>Aag	p.Q75K	HOXC-AS3_ENST00000514702.1_RNA	NM_017409.3	NP_059105.2	Q9NYD6	HXC10_HUMAN	homeobox C10	75					positive regulation of cell proliferation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(14)|pancreas(1)	20						CTACCTCTCGCAGCTGGACTC	0.667000													3	29					0.150653	0.155077	1	1	0
KIF21A	55605	broad.mit.edu	37	12	39745694	39745694	+	Missense_Mutation	SNP	A	A	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:39745694A>C	ENST00000395670.3	-	11	1977	c.1558T>G	c.(1558-1560)Tca>Gca	p.S520A	KIF21A_ENST00000544797.2_Missense_Mutation_p.S520A|KIF21A_ENST00000361418.5_Missense_Mutation_p.S520A|KIF21A_ENST00000541463.2_Missense_Mutation_p.S520A|KIF21A_ENST00000361961.3_Missense_Mutation_p.S520A			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	520					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				AAAGTTGATGATCCGCTGAAA	0.348000													4	95					0	0	1	0	0
USP9X	8239	broad.mit.edu	37	X	41060455	41060455	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:41060455G>C	ENST00000324545.8	+	31	5379	c.4746G>C	c.(4744-4746)agG>agC	p.R1582S	USP9X_ENST00000378308.2_Missense_Mutation_p.R1582S	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked						BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						CTTCCATTAGGAACGGTATTC	0.448000													5	50					0	0	1	0	0
LPIN2	9663	broad.mit.edu	37	18	2951276	2951276	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr18:2951276C>A	ENST00000261596.4	-	4	605	c.367G>T	c.(367-369)Gtg>Ttg	p.V123L	RP11-737O24.2_ENST00000584431.1_RNA	NM_014646.2	NP_055461.1	Q92539	LPIN2_HUMAN	lipin 2	123					fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	29				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		CCCGATTTCACCAAAGGGGTG	0.408000													3	52					6.4e-05	7.78283e-05	1	1	0
DAND5	199699	broad.mit.edu	37	19	13080516	13080516	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:13080516C>A	ENST00000317060.2	+	1	221	c.42C>A	c.(40-42)agC>agA	p.S14R	DAND5_ENST00000585548.1_Missense_Mutation_p.S44R	NM_152654.2	NP_689867.1	Q8N907	DAND5_HUMAN	DAN domain family member 5, BMP antagonist	14						extracellular region				kidney(2)|lung(3)|ovary(1)	6			OV - Ovarian serous cystadenocarcinoma(19;1.87e-18)			GCCTGCTTAGCGGGGCCCTGC	0.637000													10	94					3.07112e-06	3.93078e-06	1	1	0
DOCK7	85440	broad.mit.edu	37	1	63024686	63024686	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:63024686C>A	ENST00000251157.5	-	20	2438	c.2405G>T	c.(2404-2406)aGa>aTa	p.R802I	DOCK7_ENST00000340370.5_Missense_Mutation_p.R802I	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	802					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						GACAGGAGGTCTAATAACTAA	0.343000													4	31					0.00024832	0.000293427	1	1	0
DLGAP4	22839	broad.mit.edu	37	20	35060907	35060907	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr20:35060907G>C	ENST00000373913.3	+	3	1267	c.787G>C	c.(787-789)Gag>Cag	p.E263Q	DLGAP4_ENST00000339266.5_Missense_Mutation_p.E263Q|DLGAP4_ENST00000373907.2_Missense_Mutation_p.E263Q|DLGAP4_ENST00000401952.2_Missense_Mutation_p.E263Q			Q9Y2H0	DLGP4_HUMAN	discs, large (Drosophila) homolog-associated protein 4	263					cell-cell signaling	membrane	protein binding	p.E263*(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(20)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CAACACTACTGAGCTGACTGC	0.627000													5	35					0	0	1	0	0
IQCC	55721	broad.mit.edu	37	1	32673416	32673416	+	Silent	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:32673416G>A	ENST00000537469.1	+	5	1421	c.1374G>A	c.(1372-1374)gaG>gaA	p.E458E	IQCC_ENST00000291358.6_Silent_p.E378E	NM_001160042.1	NP_001153514.1	Q4KMZ1	IQCC_HUMAN	IQ motif containing C	378										endometrium(4)|large_intestine(1)|lung(3)|ovary(4)|skin(2)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GCCTCTCAGAGGACCACATCA	0.522000													4	48					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77396028	77396028	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr16:77396028C>A	ENST00000282849.5	-	7	1608	c.1190G>T	c.(1189-1191)tGg>tTg	p.W397L		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	397	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TTCATTCTTCCAAGAACAAAT	0.398000													3	41					0.004672	0.00517199	1	1	0
SLC6A15	55117	broad.mit.edu	37	12	85279839	85279839	+	Translation_Start_Site	SNP	G	G	C	rs143012212	by1000genomes	TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:85279839G>C	ENST00000552192.1	-	0	287				SLC6A15_ENST00000266682.5_Missense_Mutation_p.L100V|SLC6A15_ENST00000450363.3_Missense_Mutation_p.L100V|SLC6A15_ENST00000551388.1_Intron	NM_001146335.2	NP_001139807.1	Q9H2J7	S6A15_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 15						cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						TATGGTAAAAGATATGCACCT	0.308000													7	58					0	0	1	0	0
CRNN	49860	broad.mit.edu	37	1	152384703	152384703	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:152384703G>A	ENST00000271835.3	-	2	69	c.7C>T	c.(7-9)Cag>Tag	p.Q3*	RP1-91G5.3_ENST00000411804.1_RNA	NM_016190.2	NP_057274.1	Q9UBG3	CRNN_HUMAN	cornulin	3					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCAGTAACTGAGGCATCTTT	0.493000													5	54					0	0	1	0	0
DUSP18	150290	broad.mit.edu	37	22	31059774	31059774	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr22:31059774C>T	ENST00000334679.3	-	2	722	c.217G>A	c.(217-219)Gac>Aac	p.D73N	DUSP18_ENST00000407308.1_Missense_Mutation_p.D73N|DUSP18_ENST00000404885.1_Missense_Mutation_p.D73N|DUSP18_ENST00000461301.1_Intron|DUSP18_ENST00000403268.1_Intron	NM_152511.3	NP_689724.3	Q8NEJ0	DUS18_HUMAN	dual specificity phosphatase 18	73						cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			large_intestine(1)|lung(1)|prostate(1)|skin(1)	4						TTAGGGGAGTCAGCCACAGGT	0.507000													12	45					0	0	1	0	0
CHI3L2	1117	broad.mit.edu	37	1	111773891	111773891	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:111773891G>C	ENST00000445067.2	+	6	1075	c.304G>C	c.(304-306)Gga>Cga	p.G102R	CHI3L2_ENST00000369744.2_Missense_Mutation_p.G92R|CHI3L2_ENST00000524472.1_Missense_Mutation_p.G23R|CHI3L2_ENST00000369748.4_Missense_Mutation_p.G102R|CHI3L2_ENST00000466741.1_Missense_Mutation_p.G23R			Q15782	CH3L2_HUMAN	chitinase 3-like 2	102					chitin catabolic process	extracellular space	cation binding|chitinase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(8)|prostate(1)	19		all_cancers(81;1.89e-05)|all_epithelial(167;7.36e-06)|all_lung(203;0.00018)|Lung NSC(277;0.000359)		Lung(183;0.0171)|Colorectal(144;0.0387)|all cancers(265;0.0464)|LUSC - Lung squamous cell carcinoma(189;0.0872)|Epithelial(280;0.0994)|COAD - Colon adenocarcinoma(174;0.141)		CTTGTCCATTGGAGGGTACCT	0.363000													4	66					0	0	1	0	0
WDR20	91833	broad.mit.edu	37	14	102675281	102675281	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr14:102675281G>C	ENST00000335263.5	+	3	854	c.774G>C	c.(772-774)atG>atC	p.M258I	WDR20_ENST00000545563.1_Missense_Mutation_p.M85I|WDR20_ENST00000556511.2_Missense_Mutation_p.M197I|WDR20_ENST00000342702.3_Missense_Mutation_p.M258I|WDR20_ENST00000424963.2_Missense_Mutation_p.M134I|WDR20_ENST00000499851.2_Start_Codon_SNP_p.M1I|WDR20_ENST00000322340.5_Intron|WDR20_ENST00000454394.2_Missense_Mutation_p.M289I|WDR20_ENST00000556807.1_Missense_Mutation_p.M197I|WDR20_ENST00000299135.6_3'UTR	NM_181291.2	NP_851808.1	Q8TBZ3	WDR20_HUMAN	WD repeat domain 20	258										breast(1)|large_intestine(2)|lung(4)|prostate(1)	8						ACGGTACGATGAAAAGCTACT	0.552000													4	27					0	0	1	0	0
FAM208B	54906	broad.mit.edu	37	10	5788318	5788318	+	Silent	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr10:5788318C>A	ENST00000328090.5	+	15	3559	c.2934C>A	c.(2932-2934)acC>acA	p.T978T		NM_017782.4	NP_060252	Q5VWN6	CJ018_HUMAN	family with sequence similarity 208, member B	978																	CCACATTCACCAGGACTTACG	0.473000													8	63					0.00307968	0.00345779	1	1	0
FADS3	3995	broad.mit.edu	37	11	61647624	61647624	+	Splice_Site	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:61647624C>A	ENST00000540820.1	-	2	286		c.e2-1		FADS3_ENST00000527697.1_Splice_Site|FADS3_ENST00000525588.1_Splice_Site|FADS3_ENST00000278829.2_Splice_Site			Q9Y5Q0	FADS3_HUMAN	fatty acid desaturase 3						electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	heme binding|oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						GGAAGGCATCCTGAAGGAGAG	0.567000													8	25					3.09899e-07	4.10811e-07	1	1	0
DIDO1	11083	broad.mit.edu	37	20	61510964	61510964	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr20:61510964C>T	ENST00000266070.4	-	16	6669	c.6344G>A	c.(6343-6345)aGa>aAa	p.R2115K	DIDO1_ENST00000395343.1_Missense_Mutation_p.R2115K	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	2115	Arg-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					CTCGCGCTCTCTCCTCCTGTC	0.701000													9	135					0	0	1	0	0
RBBP8	5932	broad.mit.edu	37	18	20586357	20586357	+	Silent	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr18:20586357G>A	ENST00000399722.2	+	16	2670	c.2319G>A	c.(2317-2319)caG>caA	p.Q773Q	RBBP8_ENST00000327155.5_Silent_p.Q773Q|RBBP8_ENST00000360790.5_Silent_p.Q778Q|RBBP8_ENST00000399725.2_Silent_p.Q773Q	NM_203291.1	NP_976036.1	Q99708	COM1_HUMAN	retinoblastoma binding protein 8	773					cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			central_nervous_system(1)|cervix(2)|endometrium(5)|large_intestine(2)|lung(9)|ovary(3)|prostate(1)|skin(1)	24	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			AAGTCAAGCAGAAAGCGTTTG	0.323000								Homologous recombination					3	45					0	0	1	0	0
SLITRK4	139065	broad.mit.edu	37	X	142718438	142718438	+	Missense_Mutation	SNP	T	T	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:142718438T>A	ENST00000381779.4	-	2	712	c.487A>T	c.(487-489)Aat>Tat	p.N163Y	SLITRK4_ENST00000356928.1_Missense_Mutation_p.N163Y|SLITRK4_ENST00000338017.4_Missense_Mutation_p.N163Y	NM_001184749.2|NM_001184750.1|NM_173078.4	NP_001171678.1|NP_001171679.1|NP_775101.1	Q8IW52	SLIK4_HUMAN	SLIT and NTRK-like family, member 4	163						integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(27)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	60	Acute lymphoblastic leukemia(192;6.56e-05)					AGATTGTCATTAAGAATGAGA	0.383000													19	110					0	0	1	0	0
MARCH7	64844	broad.mit.edu	37	2	160621181	160621181	+	Silent	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:160621181C>G	ENST00000259050.4	+	9	2174	c.2052C>G	c.(2050-2052)ctC>ctG	p.L684L	MARCH7_ENST00000409591.1_Silent_p.L646L|MARCH7_ENST00000539065.1_Intron|MARCH7_ENST00000409175.1_Silent_p.L684L	NM_001282805.1|NM_001282807.1|NM_022826.2	NP_001269734.1|NP_001269736.1|NP_073737.1	Q9H992	MARH7_HUMAN	membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase								ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|stomach(2)	18						TGGAAGATCTCGAAAGTAGGT	0.353000													6	75					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33576407	33576407	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:33576407C>T	ENST00000504830.1	-	19	4059	c.3724G>A	c.(3724-3726)Gaa>Aaa	p.E1242K	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.E1157K	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1242	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						GCTGGCTTTTCAGTAACCATC	0.552000										HNSCC(64;0.19)			10	91					0	0	1	0	0
ZNF222	7673	broad.mit.edu	37	19	44536063	44536063	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:44536063A>G	ENST00000187879.8	+	4	398	c.236A>G	c.(235-237)gAc>gGc	p.D79G	ZNF223_ENST00000591793.1_Intron|ZNF222_ENST00000391960.3_Missense_Mutation_p.D119G	NM_013360.2	NP_037492.2	Q9UK12	ZN222_HUMAN	zinc finger protein 222	79	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(7)|lung(6)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	20		Prostate(69;0.0435)				ATTGCAAGTGACTTAACCAGG	0.408000													14	48					0	0	1	0	0
UBR2	23304	broad.mit.edu	37	6	42613228	42613228	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr6:42613228G>C	ENST00000372901.1	+	21	2567	c.2309G>C	c.(2308-2310)gGa>gCa	p.G770A	UBR2_ENST00000372883.3_Missense_Mutation_p.G274A|UBR2_ENST00000372899.1_Missense_Mutation_p.G770A			Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin 2	770					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(7)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|skin(5)	64	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			CCTGGAGTTGGACAGGTAAAT	0.338000													10	31					0	0	1	0	0
GBP4	115361	broad.mit.edu	37	1	89655855	89655855	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:89655855G>T	ENST00000355754.6	-	7	1160	c.1063C>A	c.(1063-1065)Cag>Aag	p.Q355K		NM_052941.4	NP_443173.2	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	355						cytoplasm	GTP binding|GTPase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(19)|skin(1)|stomach(2)|urinary_tract(1)	33				all cancers(265;0.00723)|Epithelial(280;0.0291)		CTCAGTTGCTGGGCCATCTGC	0.592000													3	40					6.4e-05	7.78283e-05	1	1	0
ARHGAP25	9938	broad.mit.edu	37	2	69049647	69049647	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:69049647A>G	ENST00000295381.3	+	10	1792	c.1373A>G	c.(1372-1374)aAc>aGc	p.N458S	ARHGAP25_ENST00000409220.1_Missense_Mutation_p.N452S|ARHGAP25_ENST00000409030.3_Missense_Mutation_p.N451S|ARHGAP25_ENST00000409202.3_Missense_Mutation_p.N459S|ARHGAP25_ENST00000479844.1_Missense_Mutation_p.N152S|ARHGAP25_ENST00000467265.1_Missense_Mutation_p.N419S	NM_001007231.2	NP_001007232.2	P42331	RHG25_HUMAN	Rho GTPase activating protein 25	458					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(20)|ovary(3)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	52						CAGGGTGCCAACAGCAGCAAA	0.483000													6	64					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	41076862	41076862	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr20:41076862C>T	ENST00000373198.4	-	9	1793	c.1558G>A	c.(1558-1560)Gag>Aag	p.E520K	PTPRT_ENST00000373201.1_Missense_Mutation_p.E520K|PTPRT_ENST00000356100.2_Missense_Mutation_p.E520K|PTPRT_ENST00000373193.3_Missense_Mutation_p.E520K|PTPRT_ENST00000373190.1_Missense_Mutation_p.E520K|PTPRT_ENST00000373184.1_Missense_Mutation_p.E520K|PTPRT_ENST00000373187.1_Missense_Mutation_p.E520K	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T		Fibronectin type-III 3.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CTCCTTACCTCGTAGAGCGTG	0.488000													19	112					0	0	1	0	0
ZNF613	79898	broad.mit.edu	37	19	52443932	52443932	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:52443932G>A	ENST00000293471.6	+	5	884	c.205G>A	c.(205-207)Gaa>Aaa	p.E69K	ZNF613_ENST00000391794.4_Missense_Mutation_p.E33K	NM_001031721.3	NP_001026891.2	Q6PF04	ZN613_HUMAN	zinc finger protein 613	69	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	19		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.0183)		ATGGACAGTAGAAAATGAAAT	0.468000													13	52					0	0	1	0	0
GP9	2815	broad.mit.edu	37	3	128780788	128780788	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:128780788G>A	ENST00000307395.4	+	3	428	c.206G>A	c.(205-207)gGa>gAa	p.G69E		NM_000174.3	NP_000165.1	P14770	GPIX_HUMAN	glycoprotein IX (platelet)	69					blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane	protein binding			NS(1)|central_nervous_system(1)|lung(4)	6					Quinine(DB00468)	GTGCCCCCGGGAGCCTTTGAC	0.682000													3	11					0	0	1	0	0
TNFAIP8L1	126282	broad.mit.edu	37	19	4651999	4651999	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:4651999G>A	ENST00000536716.1	+	2	264	c.118G>A	c.(118-120)Gat>Aat	p.D40N	TNFAIP8L1_ENST00000327473.4_Missense_Mutation_p.D40N	NM_001167942.1	NP_001161414.1	Q8WVP5	TP8L1_HUMAN	tumor necrosis factor, alpha-induced protein 8-like 1	40										endometrium(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		TGAGGTGCTGGATGAGCTGTA	0.617000													5	21					0	0	1	0	0
DDX23	9416	broad.mit.edu	37	12	49230396	49230396	+	Silent	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:49230396G>A	ENST00000308025.3	-	10	1271	c.1192C>T	c.(1192-1194)Ctg>Ttg	p.L398L		NM_004818.2	NP_004809.2	Q9BUQ8	DDX23_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	398						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent RNA helicase activity|nucleic acid binding|protein binding			NS(1)|cervix(1)|kidney(4)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|urinary_tract(3)	36						TGTGGGGGCAGAGAAGAGTCT	0.517000													7	60					0	0	1	0	0
HABP2	3026	broad.mit.edu	37	10	115344031	115344031	+	Silent	SNP	T	T	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr10:115344031T>C	ENST00000351270.3	+	11	1458	c.1362T>C	c.(1360-1362)gtT>gtC	p.V454V	HABP2_ENST00000542051.1_Silent_p.V428V	NM_004132.3	NP_004123.1	Q14520	HABP2_HUMAN	hyaluronan binding protein 2	454	Peptidase S1.				cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		GCTGGGGTGTTACAGAAACAG	0.493000													6	35					0	0	1	0	0
SEC63	11231	broad.mit.edu	37	6	108204218	108204218	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr6:108204218C>A	ENST00000369002.4	-	17	1986	c.1807G>T	c.(1807-1809)Gaa>Taa	p.E603*		NM_007214.4	NP_009145.1	Q9UGP8	SEC63_HUMAN	SEC63 homolog (S. cerevisiae)	603					protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding			endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		TTTTGTTTTTCATCTTGCTCT	0.338000													8	46					1.08611e-07	1.44585e-07	1	1	0
POM121L9P	29774	broad.mit.edu	37	22	24659734	24659734	+	RNA	SNP	T	T	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr22:24659734T>C	ENST00000414583.2	+	0	3259					NR_003714.1																						CTCTCTCCTGTGGGAGGGGGG	0.632000													3	1					0	0	1	0	0
CELA3B	23436	broad.mit.edu	37	1	22310252	22310252	+	Nonsense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:22310252C>G	ENST00000337107.6	+	5	447	c.428C>G	c.(427-429)tCa>tGa	p.S143*		NM_007352.2	NP_031378.1	P08861	CEL3B_HUMAN	chymotrypsin-like elastase family, member 3B	143	Peptidase S1.				cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	8						CAGCTCGCCTCACTCCCTCCG	0.627000													7	45					0	0	1	0	0
GPBP1L1	60313	broad.mit.edu	37	1	46120320	46120320	+	Silent	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:46120320G>A	ENST00000355105.3	-	6	1732	c.372C>T	c.(370-372)ttC>ttT	p.F124F	GPBP1L1_ENST00000290795.3_Silent_p.F124F	NM_021639.4	NP_067652.1	Q9HC44	GPBL1_HUMAN	GC-rich promoter binding protein 1-like 1	124					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding		GPBP1L1/MAST2_ENST00000361297(2)	breast(1)|endometrium(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|stomach(1)	21	Acute lymphoblastic leukemia(166;0.155)					TCCGGGAGTGGAAGCTGCCAT	0.512000													7	44					0	0	1	0	0
CMA1	1215	broad.mit.edu	37	14	24975399	24975399	+	Silent	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr14:24975399C>A	ENST00000250378.3	-	4	464	c.435G>T	c.(433-435)cgG>cgT	p.R145R	CMA1_ENST00000206446.4_Silent_p.R34R|RP11-80A15.1_ENST00000555109.1_Intron	NM_001836.3	NP_001827.1	P23946	CMA1_HUMAN	chymase 1, mast cell	145	Peptidase S1.				interleukin-1 beta biosynthetic process|proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|lung(8)|pancreas(1)|prostate(1)	11				GBM - Glioblastoma multiforme(265;0.0271)		AGCCAGCCACCCGGCACATTC	0.582000													3	30					0.00909568	0.00992971	1	1	0
EPM2AIP1	9852	broad.mit.edu	37	3	37032824	37032824	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:37032824G>A	ENST00000322716.5	-	1	1971	c.1745C>T	c.(1744-1746)gCc>gTc	p.A582V		NM_014805.3	NP_055620.1	Q7L775	EPMIP_HUMAN	EPM2A (laforin) interacting protein 1	582						endoplasmic reticulum				breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(12)|ovary(2)	27						CCGAAACAGGGCTTGGAGATG	0.413000													9	95					0	0	1	0	0
DHX58	79132	broad.mit.edu	37	17	40256928	40256928	+	Silent	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:40256928C>G	ENST00000251642.3	-	11	1641	c.1419G>C	c.(1417-1419)cgG>cgC	p.R473R		NM_024119.2	NP_077024.2	Q96C10	DHX58_HUMAN	DEXH (Asp-Glu-X-His) box polypeptide 58	473	Helicase C-terminal.			R -> W (in Ref. 1; BAB13818).	innate immune response	cytoplasm	ATP binding|DNA binding|helicase activity|protein binding|RNA binding|zinc ion binding			breast(2)|endometrium(3)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_cancers(22;9.73e-07)|all_epithelial(22;3.58e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TCTGATCGGCCCGGGCACGGC	0.627000													13	38					0	0	1	0	0
LIMA1	51474	broad.mit.edu	37	12	50616023	50616023	+	Silent	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:50616023G>A	ENST00000341247.4	-	4	560	c.411C>T	c.(409-411)ctC>ctT	p.L137L	LIMA1_ENST00000552783.1_5'UTR|LIMA1_ENST00000394943.3_Silent_p.L137L|LIMA1_ENST00000552909.1_5'UTR|LIMA1_ENST00000552823.1_5'UTR|RP3-405J10.4_ENST00000551284.1_RNA	NM_001113546.1|NM_016357.4	NP_001107018.1|NP_057441.1	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1	137					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			NS(1)|breast(4)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(2)	44						GACCCTGAACGAGGGCTTCAG	0.488000													8	62					0	0	1	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140774319	140774319	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:140774319C>T	ENST00000398604.2	+	1	1939	c.1939C>T	c.(1939-1941)Cag>Tag	p.Q647*	PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGB3_ENST00000576222.1_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGGCCGTCCAGGACCATGG	0.677000													4	25					0	0	1	0	0
CYP4F22	126410	broad.mit.edu	37	19	15661506	15661506	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:15661506G>T	ENST00000269703.3	+	13	1556	c.1357G>T	c.(1357-1359)Gac>Tac	p.D453Y	CYP4F22_ENST00000601005.2_Missense_Mutation_p.D453Y	NM_173483.3	NP_775754.2	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 22							endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			endometrium(6)|large_intestine(9)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|soft_tissue(1)	37						CTACCGCTTTGACCCGGACAA	0.617000													9	43					2.17888e-05	2.69583e-05	1	1	0
PTPRT	11122	broad.mit.edu	37	20	41419868	41419868	+	Silent	SNP	G	G	C	rs140340339		TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr20:41419868G>C	ENST00000373198.4	-	3	688	c.453C>G	c.(451-453)ctC>ctG	p.L151L	PTPRT_ENST00000373201.1_Silent_p.L151L|PTPRT_ENST00000356100.2_Silent_p.L151L|PTPRT_ENST00000373193.3_Silent_p.L151L|PTPRT_ENST00000373190.1_Silent_p.L151L|PTPRT_ENST00000373184.1_Silent_p.L151L|PTPRT_ENST00000373187.1_Silent_p.L151L	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T		MAM.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity	p.L151L(2)		NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TGCTGATGGCGAGCTCTGCCT	0.488000													14	69					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123419168	123419168	+	Silent	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:123419168G>T	ENST00000360772.3	-	19	3525	c.3147C>A	c.(3145-3147)ccC>ccA	p.P1049P	MYLK_ENST00000359169.1_Silent_p.P1049P|MYLK_ENST00000475616.1_Silent_p.P1049P|MYLK_ENST00000346322.5_Silent_p.P980P|MYLK_ENST00000360304.3_Silent_p.P1049P			Q15746	MYLK_HUMAN	myosin light chain kinase	1049	6 X 12 AA approximate tandem repeats.			KPM -> EAH (in Ref. 1 and 7).	aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CATTGCCCATGGGCTTCAGGG	0.547000													14	159					3.32936e-07	4.40425e-07	1	1	0
UVSSA	57654	broad.mit.edu	37	4	1347031	1347031	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr4:1347031G>C	ENST00000389851.4	+	5	1211	c.764G>C	c.(763-765)aGa>aCa	p.R255T	UVSSA_ENST00000507531.1_Missense_Mutation_p.R255T|UVSSA_ENST00000511216.1_Missense_Mutation_p.R255T	NM_020894.2	NP_065945.2	Q2YD98	K1530_HUMAN	UV-stimulated scaffold protein A	255																	TGCTGCAGTAGAGACCTGCCT	0.716000													3	23					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123637414	123637414	+	Missense_Mutation	SNP	T	T	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:123637414T>A	ENST00000422452.2	-	19	3504	c.3441A>T	c.(3439-3441)caA>caT	p.Q1147H	TENM1_ENST00000371130.3_Missense_Mutation_p.Q1147H	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		ACTTACCACTTTGAGGATTCA	0.328000													20	129					0	0	1	0	0
ST3GAL3	6487	broad.mit.edu	37	1	44365307	44365307	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:44365307G>C	ENST00000262915.3	+	10	1036	c.859G>C	c.(859-861)Gag>Cag	p.E287Q	ST3GAL3_ENST00000361746.4_Missense_Mutation_p.E287Q|ST3GAL3_ENST00000361400.4_Missense_Mutation_p.E202Q|ST3GAL3_ENST00000531451.1_Intron|ST3GAL3_ENST00000372362.2_Intron|ST3GAL3_ENST00000330208.2_Intron|ST3GAL3_ENST00000332628.6_Missense_Mutation_p.E187Q|ST3GAL3_ENST00000372369.1_Missense_Mutation_p.E218Q|ST3GAL3_ENST00000372374.2_Missense_Mutation_p.E187Q|ST3GAL3_ENST00000372375.2_Missense_Mutation_p.E272Q|ST3GAL3_ENST00000531816.1_Intron|ST3GAL3_ENST00000361392.4_Missense_Mutation_p.E218Q|ST3GAL3_ENST00000361812.4_Intron|ST3GAL3_ENST00000372365.1_Intron|ST3GAL3_ENST00000533933.1_Missense_Mutation_p.E218Q|ST3GAL3_ENST00000531993.1_Missense_Mutation_p.E202Q|ST3GAL3_ENST00000528371.1_Intron|ST3GAL3_ENST00000347631.2_Missense_Mutation_p.E233Q|ST3GAL3_ENST00000372372.2_Missense_Mutation_p.E256Q|ST3GAL3_ENST00000372367.1_Intron|ST3GAL3_ENST00000335430.6_Intron|ST3GAL3_ENST00000372366.1_Intron|ST3GAL3_ENST00000461375.1_3'UTR|ST3GAL3_ENST00000545417.1_Intron|ST3GAL3_ENST00000372377.4_Intron|ST3GAL3_ENST00000351035.3_Missense_Mutation_p.E256Q|ST3GAL3_ENST00000372368.2_Missense_Mutation_p.E272Q|ST3GAL3_ENST00000353126.3_Missense_Mutation_p.E218Q	NM_174963.3	NP_777623.2	Q11203	SIAT6_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	218					protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	N-acetyllactosaminide alpha-2,3-sialyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(3)|skin(1)	19	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0518)				GCAGCGGCCTGAGCAGTACGA	0.542000													4	46					0	0	1	0	0
PDE1B	5153	broad.mit.edu	37	12	54969376	54969376	+	Silent	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:54969376C>G	ENST00000243052.3	+	12	1663	c.1227C>G	c.(1225-1227)ctC>ctG	p.L409L	PPP1R1A_ENST00000547431.1_3'UTR|PDE1B_ENST00000550620.1_Silent_p.L389L|PDE1B_ENST00000538346.1_Silent_p.L368L|PDE1B_ENST00000394277.3_3'UTR	NM_000924.3	NP_000915.1	Q01064	PDE1B_HUMAN	phosphodiesterase 1B, calmodulin-dependent	409	Catalytic (By similarity).				activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(4)	31						TTTCTCCACTCTGTGACCGCA	0.572000													4	70					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856112	53856112	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:53856112C>T	ENST00000458035.1	+	4	2301	c.2184C>T	c.(2182-2184)ttC>ttT	p.F728F	ZNF845_ENST00000595091.1_Silent_p.F728F	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	728				Missing (in Ref. 1; BAG58121).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						GCAAGGCCTTCAGTCAGAAGT	0.423000													13	133					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23524554	23524554	+	Silent	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:23524554G>T	ENST00000296682.3	+	10	1244	c.1062G>T	c.(1060-1062)ctG>ctT	p.L354L		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	354	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						GTGAACTGCTGGTCTGGTATG	0.542000										HNSCC(3;0.000094)			10	41					0.000442599	0.000515277	1	1	0
KCNH7	90134	broad.mit.edu	37	2	163250972	163250972	+	Silent	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:163250972G>T	ENST00000332142.5	-	12	2736	c.2637C>A	c.(2635-2637)tcC>tcA	p.S879S		NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	879					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	AATCATTCATGGATTGTGATC	0.323000													6	42					0.000157383	0.000187375	1	1	0
LILRB5	10990	broad.mit.edu	37	19	54754719	54754719	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:54754719C>A	ENST00000316219.5	-	13	1811	c.1704G>T	c.(1702-1704)gaG>gaT	p.E568D	LILRB5_ENST00000449561.2_Missense_Mutation_p.E569D|LILRB5_ENST00000450632.1_3'UTR|LILRB5_ENST00000345866.6_Missense_Mutation_p.E469D	NM_001081442.1|NM_006840.3	NP_001074911.1|NP_006831.1	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	568					cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ATGGAGGAGGCTCAGTTGCCT	0.622000													12	48					6.81908e-15	9.58316e-15	1	1	0
MUC5B	727897	broad.mit.edu	37	11	1272927	1272927	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:1272927C>G	ENST00000447027.1	+	31	14884	c.14826C>G	c.(14824-14826)ttC>ttG	p.F4942L	MUC5B_ENST00000529681.1_Missense_Mutation_p.F4939L			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4939					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GCTCCCACTTCTCTACTCCCT	0.582000													3	30					0	0	1	0	0
NOP2	4839	broad.mit.edu	37	12	6666446	6666446	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:6666446C>T	ENST00000541778.1	-	16	2628	c.2140G>A	c.(2140-2142)Gcc>Acc	p.A714T	NOP2_ENST00000399466.2_Missense_Mutation_p.A714T|NOP2_ENST00000322166.5_Missense_Mutation_p.A718T|NOP2_ENST00000382421.3_Missense_Mutation_p.A751T|NOP2_ENST00000537442.1_Missense_Mutation_p.A718T|NOP2_ENST00000545200.1_3'UTR|NOP2_ENST00000542015.1_5'UTR			P46087	NOP2_HUMAN	NOP2 nucleolar protein	718					positive regulation of cell proliferation|rRNA processing	nucleolus	protein binding|RNA binding|S-adenosylmethionine-dependent methyltransferase activity			breast(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	19						TTGGGAGGGGCATTCTGCCTG	0.522000													40	103					0	0	1	0	0
GNAT2	2780	broad.mit.edu	37	1	110151338	110151338	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:110151338C>T	ENST00000351050.3	-	4	562	c.376G>A	c.(376-378)Gtc>Atc	p.V126I		NM_005272.3	NP_005263.1	P19087	GNAT2_HUMAN	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2	126					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	G-protein beta/gamma-subunit complex binding|G-protein coupled photoreceptor activity|G-protein-coupled receptor binding|GTP binding|GTPase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	14		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0422)|Colorectal(144;0.108)|Epithelial(280;0.125)|all cancers(265;0.129)|LUSC - Lung squamous cell carcinoma(189;0.227)		CTCCTAATGACCTCCACGAGC	0.522000													8	46					0	0	1	0	0
FAIM3	9214	broad.mit.edu	37	1	207086276	207086276	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:207086276C>A	ENST00000367091.3	-	3	628	c.485G>T	c.(484-486)aGa>aTa	p.R162I	FAIM3_ENST00000420007.2_Missense_Mutation_p.R162I|FAIM3_ENST00000528654.1_Intron|FAIM3_ENST00000442471.2_Missense_Mutation_p.R50I	NM_005449.4	NP_005440.1	O60667	FAIM3_HUMAN	Fas apoptotic inhibitory molecule 3	162					anti-apoptosis|cellular defense response	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	15	Breast(84;0.201)					GAACTGACCTCTGGTTACGAA	0.493000											OREG0014185	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	104					0.000274275	0.000320496	1	1	0
MICAL2	9645	broad.mit.edu	37	11	12247760	12247760	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:12247760C>T	ENST00000256194.4	+	14	2019	c.1731C>T	c.(1729-1731)aaC>aaT	p.N577N	MICAL2_ENST00000379612.3_Silent_p.N577N|MICAL2_ENST00000342902.5_Silent_p.N577N|MICAL2_ENST00000537344.1_Silent_p.N577N|MICAL2_ENST00000527546.1_Silent_p.N577N	NM_001282663.1|NM_014632.2	NP_001269592.1|NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	577	CH.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		TGGAGAACAACCAGCTCGCAT	0.522000													6	86					0	0	1	0	0
GPRASP2	114928	broad.mit.edu	37	X	101970156	101970156	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:101970156C>T	ENST00000543253.1	+	5	1278	c.359C>T	c.(358-360)gCa>gTa	p.A120V	GPRASP2_ENST00000535209.1_Missense_Mutation_p.A120V|GPRASP2_ENST00000332262.5_Missense_Mutation_p.A120V	NM_001004051.3|NM_001184874.2|NM_001184876.2	NP_001004051.1|NP_001171803.1|NP_001171805.1			G protein-coupled receptor associated sorting protein 2											breast(3)|endometrium(5)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	30						ATCCCTGGAGCAAGGCCCAAG	0.572000													17	94					0	0	1	0	0
POLR3C	10623	broad.mit.edu	37	1	145594100	145594100	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:145594100C>G	ENST00000334163.3	-	14	1622	c.1462G>C	c.(1462-1464)Gag>Cag	p.E488Q	POLR3C_ENST00000369294.1_Intron	NM_006468.6	NP_006459.3	Q9BUI4	RPC3_HUMAN	polymerase (RNA) III (DNA directed) polypeptide C (62kD)	488					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)		Epithelial(2;7.55e-13)			ATCATCTCCTCTATTTCTTGT	0.438000													11	109					0	0	1	0	0
RAB6A	5870	broad.mit.edu	37	11	73388981	73388981	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:73388981G>C	ENST00000310653.6	-	8	1090	c.589C>G	c.(589-591)Cag>Gag	p.Q197E	RAB6A_ENST00000336083.3_Missense_Mutation_p.Q197E|RAB6A_ENST00000541588.1_Missense_Mutation_p.Q93E|RAB6A_ENST00000536566.1_Missense_Mutation_p.Q164E	NM_001077637.1|NM_002869.4	NP_001071105.1|NP_002860.2	P20340	RAB6A_HUMAN	RAB6A, member RAS oncogene family	197					minus-end-directed organelle transport along microtubule|peptidyl-cysteine methylation|protein targeting to Golgi|retrograde vesicle-mediated transport, Golgi to ER|small GTPase mediated signal transduction	cytoplasmic vesicle|cytosol|Golgi membrane|trans-Golgi network	GTP binding|GTPase activity|protein domain specific binding			large_intestine(2)|lung(2)	4						GGTTGCTCCTGAGGCTTTTCC	0.418000													14	53					0	0	1	0	0
TAF3	83860	broad.mit.edu	37	10	8006521	8006521	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr10:8006521G>A	ENST00000344293.5	+	3	1254	c.1048G>A	c.(1048-1050)Gaa>Aaa	p.E350K		NM_031923.3	NP_114129.1	Q5VWG9	TAF3_HUMAN	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa	350					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			NS(2)|breast(4)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(3)|prostate(4)|skin(2)	40						TACACTCAGTGAAAAAATCAG	0.498000													4	24					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232629405	232629405	+	Splice_Site	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:232629405C>T	ENST00000366630.1	-	3	1843	c.1485G>A	c.(1483-1485)gaG>gaA	p.E495E	SIPA1L2_ENST00000262861.4_Splice_Site_p.E495E|SIPA1L2_ENST00000486472.1_5'UTR			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	495					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				AGTTTTGGTGCTCTATAATGG	0.423000													13	105					0	0	1	0	0
UBA2	10054	broad.mit.edu	37	19	34942884	34942884	+	Splice_Site	SNP	A	A	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:34942884A>C	ENST00000439527.2	+	10	1081		c.e10-1		UBA2_ENST00000246548.4_Splice_Site			Q9UBT2	SAE2_HUMAN	ubiquitin-like modifier activating enzyme 2						protein sumoylation	nucleus	ATP binding|enzyme activator activity|ligase activity|metal ion binding|protein heterodimerization activity|SUMO activating enzyme activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	20	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			TTTTTTCTTTAGGAGAAGAAA	0.348000													10	31					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	7040173	7040173	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr18:7040173G>T	ENST00000389658.3	-	10	1417	c.1324C>A	c.(1324-1326)Caa>Aaa	p.Q442K		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	442	Laminin EGF-like 3.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TAGCCAAGTTGGCAGCGATCA	0.522000													3	35					0.004672	0.00517199	1	1	0
VAC14	55697	broad.mit.edu	37	16	70796924	70796924	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr16:70796924C>T	ENST00000261776.5	-	11	1425	c.1165G>A	c.(1165-1167)Gaa>Aaa	p.E389K	VAC14-AS1_ENST00000398177.1_RNA|VAC14-AS1_ENST00000562507.1_RNA	NM_018052.3	NP_060522.3	Q08AM6	VAC14_HUMAN	Vac14 homolog (S. cerevisiae)	389					interspecies interaction between organisms	endoplasmic reticulum|endosome membrane|microsome	protein binding|receptor activity			breast(2)|endometrium(2)|kidney(10)|large_intestine(1)|lung(10)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Ovarian(137;0.0699)				GGGGCTCTTTCAGTGCTGTGG	0.587000													3	17					0	0	1	0	0
CAMK1D	57118	broad.mit.edu	37	10	12856259	12856259	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr10:12856259C>T	ENST00000378847.3	+	7	1044	c.707C>T	c.(706-708)gCg>gTg	p.A236V	CAMK1D_ENST00000378845.1_Missense_Mutation_p.A236V	NM_153498.2	NP_705718.1	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	236	Protein kinase.					calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|stomach(1)	16				GBM - Glioblastoma multiforme(1;3.16e-05)		ATCCTCAAGGCGGAATATGAG	0.522000													6	46					0	0	1	0	0
HEATR6	63897	broad.mit.edu	37	17	58121446	58121446	+	Silent	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:58121446C>A	ENST00000184956.6	-	20	3040	c.3024G>T	c.(3022-3024)gtG>gtT	p.V1008V	HEATR6_ENST00000585976.1_Silent_p.V896V	NM_022070.4	NP_071353.4	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	1008							binding			NS(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	44	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			TGCATGATGTCACGACCGATG	0.532000													4	70					0.00909568	0.00992971	1	1	0
EHBP1	23301	broad.mit.edu	37	2	63176055	63176055	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:63176055G>T	ENST00000263991.5	+	14	2661	c.2179G>T	c.(2179-2181)Gac>Tac	p.D727Y	EHBP1_ENST00000405015.3_Missense_Mutation_p.D692Y|EHBP1_ENST00000354487.3_Missense_Mutation_p.D692Y|EHBP1_ENST00000405289.1_Missense_Mutation_p.D692Y|EHBP1_ENST00000431489.1_Missense_Mutation_p.D692Y	NM_015252.3	NP_056067.2	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1	727						cytoplasm|membrane				biliary_tract(1)|breast(3)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(22)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	47	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			TCAAACTCTAGACATCGGTAG	0.353000													4	40					0.184627	0.188511	1	1	0
RP11-146E13.4	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	A	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr14:19857036A>G	ENST00000548109.1	+	0	72																											CTGGATAATAAAGTTCATCTC	0.373000													9	43					0	0	1	0	0
OR8G1	26494	broad.mit.edu	37	11	124120565	124120565	+	RNA	SNP	T	T	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:124120565T>C	ENST00000341493.2	+	0	143				OR8G1_ENST00000534473.2_RNA	NM_001002905.1	NP_001002905.1	Q15617	OR8G1_HUMAN	olfactory receptor, family 8, subfamily G, member 1						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity						Breast(109;0.0157)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;5.28e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0569)|Lung(307;0.174)		ATGACCACACTGATTTGGCTC	0.522000													6	69					0	0	1	0	0
CNIH2	254263	broad.mit.edu	37	11	66050541	66050541	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:66050541C>G	ENST00000528852.1	+	4	501	c.234C>G	c.(232-234)ttC>ttG	p.F78L	CNIH2_ENST00000311445.6_Missense_Mutation_p.F78L|CNIH2_ENST00000530519.1_3'UTR			Q6PI25	CNIH2_HUMAN	cornichon family AMPA receptor auxiliary protein 2	78					intracellular signal transduction|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic shaft|dendritic spine|endoplasmic reticulum membrane|postsynaptic density|postsynaptic membrane	protein binding			endometrium(1)|large_intestine(1)|lung(2)|prostate(1)	5						ACGGCCTCTTCTGTCTGATGT	0.602000											OREG0021100	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	71					0	0	1	0	0
TRIM38	10475	broad.mit.edu	37	6	25966926	25966926	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr6:25966926G>C	ENST00000357085.3	+	3	652	c.176G>C	c.(175-177)tGt>tCt	p.C59S	TRIM38_ENST00000349458.3_Missense_Mutation_p.C59S	NM_006355.3	NP_006346.1	O00635	TRI38_HUMAN	tripartite motif containing 38	59					positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular	signal transducer activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(8)|upper_aerodigestive_tract(2)	23						ACATTCTGCTGTCCCCAGTGT	0.488000													8	31					0	0	1	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120317777	120317777	+	Silent	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:120317777C>A	ENST00000397843.2	+	18	1738	c.1572C>A	c.(1570-1572)gcC>gcA	p.A524A	ARHGEF12_ENST00000532993.1_Silent_p.A421A|ARHGEF12_ENST00000356641.3_Silent_p.A505A	NM_015313.2	NP_056128.1	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	524	RGSL.				apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(5)|endometrium(6)|kidney(5)|large_intestine(13)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(2)	61		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		AGATTGTTGCCAAAATTGAAG	0.428000			T	MLL	AML								12	75					9.31168e-06	1.17985e-05	1	1	0
BRS3	680	broad.mit.edu	37	X	135570547	135570547	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:135570547G>A	ENST00000370648.3	+	1	502	c.274G>A	c.(274-276)Gga>Aga	p.G92R		NM_001727.1	NP_001718.1	P32247	BRS3_HUMAN	bombesin-like receptor 3	92					adult feeding behavior|glucose metabolic process|regulation of blood pressure	integral to membrane|plasma membrane	bombesin receptor activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|pancreas(1)|prostate(1)	23	Acute lymphoblastic leukemia(192;0.000127)					CCTGGCTTTTGGAGATCTTTT	0.423000													4	112					0	0	1	0	0
CTNNBL1	56259	broad.mit.edu	37	20	36468584	36468584	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr20:36468584G>A	ENST00000405275.2	+	13	1456	c.1213G>A	c.(1213-1215)Gaa>Aaa	p.E405K	CTNNBL1_ENST00000373469.1_Missense_Mutation_p.E180K|CTNNBL1_ENST00000373473.1_Missense_Mutation_p.E245K|CTNNBL1_ENST00000473857.1_3'UTR|CTNNBL1_ENST00000361383.6_Missense_Mutation_p.E432K	NM_001281495.1	NP_001268424.1	Q8WYA6	CTBL1_HUMAN	catenin, beta like 1	432					apoptosis|positive regulation of apoptosis|somatic diversification of immunoglobulins	nucleus	enzyme binding			autonomic_ganglia(1)|breast(2)|endometrium(9)|large_intestine(6)|lung(6)|ovary(3)|urinary_tract(1)	28		Myeloproliferative disorder(115;0.00878)				TAAATTCACTGAAAATGACAG	0.512000													4	15					0	0	1	0	0
ATP8B1	5205	broad.mit.edu	37	18	55364879	55364879	+	Silent	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr18:55364879G>C	ENST00000536015.1	-	8	788	c.669C>G	c.(667-669)ctC>ctG	p.L223L	ATP8B1_ENST00000283684.4_Silent_p.L223L|RP11-35G9.3_ENST00000599199.1_RNA|RP11-35G9.5_ENST00000588925.1_RNA	NM_005603.4	NP_005594	O43520	AT8B1_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 1	223					ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(19)|ovary(3)|prostate(1)	53		Colorectal(73;0.229)				CCACATAGCAGAGGCTGTTAG	0.502000													5	70					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28983466	28983466	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr18:28983466G>A	ENST00000359747.4	+	11	1534	c.1505G>A	c.(1504-1506)aGa>aAa	p.R502K	RP11-534N16.1_ENST00000578477.1_RNA|RP11-534N16.1_ENST00000581856.1_RNA|DSG4_ENST00000308128.4_Missense_Mutation_p.R502K	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	502					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CCTGAAAGAAGAACCATCTGC	0.388000													4	49					0	0	1	0	0
DNA2	1763	broad.mit.edu	37	10	70179627	70179627	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr10:70179627T>C	ENST00000399180.2	-	18	2977	c.2978A>G	c.(2977-2979)gAa>gGa	p.E993G	DNA2_ENST00000399179.2_Missense_Mutation_p.E669G|DNA2_ENST00000358410.3_Missense_Mutation_p.E907G			P51530	DNA2L_HUMAN	DNA replication helicase/nuclease 2	907					base-excision repair|DNA replication, removal of RNA primer|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(7)|prostate(1)	20						ACCACCTTTTTCAACTTGTTC	0.363000													12	94					0	0	1	0	0
C10orf118	55088	broad.mit.edu	37	10	115895667	115895667	+	Silent	SNP	T	T	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr10:115895667T>G	ENST00000369287.3	-	9	1761	c.1495A>C	c.(1495-1497)Aga>Cga	p.R499R	C10orf118_ENST00000543782.1_Silent_p.R97R	NM_018017.2	NP_060487.2	Q7Z3E2	CJ118_HUMAN	chromosome 10 open reading frame 118	499										NS(1)|autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(9)|ovary(2)	24		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0161)|all cancers(201;0.0397)		CTCAGTGTTCTTAACTCATCC	0.323000													4	36					0	0	1	0	0
FSCB	84075	broad.mit.edu	37	14	44975854	44975854	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr14:44975854G>C	ENST00000340446.4	-	1	628	c.337C>G	c.(337-339)Cag>Gag	p.Q113E		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	113						cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		TCTACATCCTGAACACTCTCT	0.423000													11	140					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64596563	64596563	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr14:64596563G>A	ENST00000357395.3	+	76	14382	c.3238G>A	c.(3238-3240)Gaa>Aaa	p.E1080K	SYNE2_ENST00000555002.1_Missense_Mutation_p.E1329K|SYNE2_ENST00000358025.3_Missense_Mutation_p.E4695K|SYNE2_ENST00000554584.1_Missense_Mutation_p.E4612K|SYNE2_ENST00000394768.2_Missense_Mutation_p.E1080K|SYNE2_ENST00000344113.4_Missense_Mutation_p.E4695K|ESR2_ENST00000542956.1_Intron			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	4695					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding	p.E4695K(1)		NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		ACTAAGAGATGAAGGGGAGAG	0.443000													4	33					0	0	1	0	0
BAZ1A	11177	broad.mit.edu	37	14	35276671	35276671	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr14:35276671C>T	ENST00000360310.1	-	6	1279	c.712G>A	c.(712-714)Gtc>Atc	p.V238I	BAZ1A_ENST00000358716.4_Missense_Mutation_p.V238I|BAZ1A_ENST00000382422.2_Missense_Mutation_p.V238I	NM_013448.2	NP_038476.2	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	238					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(2)|large_intestine(7)|lung(19)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		ATTTTAATGACTCCATCTTGT	0.333000													5	28					0	0	1	0	0
CETN2	1069	broad.mit.edu	37	X	151997170	151997170	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:151997170C>A	ENST00000370277.3	-	4	406	c.340G>T	c.(340-342)Gat>Tat	p.D114Y	CETN2_ENST00000493482.1_5'UTR	NM_004344.1	NP_004335.1	P41208	CETN2_HUMAN	centrin, EF-hand protein, 2	114	EF-hand 3.				cell division|centriole replication|G2/M transition of mitotic cell cycle|mitosis|nucleotide-excision repair|regulation of cytokinesis	centriole|cytosol|XPC complex	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			breast(1)|lung(4)|prostate(1)|skin(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					TCATCATCATCAAAGAGCTTG	0.423000								Direct reversal of damage;Nucleotide excision repair (NER)					5	86					0.184627	0.188511	1	1	0
PHF20	51230	broad.mit.edu	37	20	34389511	34389511	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr20:34389511G>T	ENST00000374012.3	+	2	196	c.67G>T	c.(67-69)Gac>Tac	p.D23Y	PHF20_ENST00000439301.1_Missense_Mutation_p.D23Y|PHF20_ENST00000481202.1_3'UTR			Q9BVI0	PHF20_HUMAN	PHD finger protein 20	23					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			breast(5)|endometrium(1)|kidney(7)|large_intestine(6)|lung(11)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(12;0.00631)|all_lung(11;0.0145)					GGAAGCCCGGGACCGTTTAAA	0.428000													5	36					0.0215528	0.0229339	1	1	0
MCRS1	10445	broad.mit.edu	37	12	49952692	49952692	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:49952692G>C	ENST00000550165.1	-	15	1502	c.1236C>G	c.(1234-1236)atC>atG	p.I412M	MCRS1_ENST00000546244.1_Missense_Mutation_p.I221M|MCRS1_ENST00000357123.4_Missense_Mutation_p.I425M|MCRS1_ENST00000343810.4_Missense_Mutation_p.I412M|MCRS1_ENST00000547182.1_5'UTR			Q96EZ8	MCRS1_HUMAN	microspherule protein 1	412	FHA.				DNA recombination|DNA repair|protein modification process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|MLL1 complex|nucleolus	protein binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(11)	23						CATCGATGTAGATGGGCCGTC	0.557000													3	31					0	0	1	0	0
ZNF474	133923	broad.mit.edu	37	5	121488307	121488307	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:121488307C>A	ENST00000296600.4	+	2	1005	c.622C>A	c.(622-624)Ctc>Atc	p.L208I	ZNF474_ENST00000514925.1_Intron|CTC-441N14.2_ENST00000504829.1_RNA	NM_207317.1	NP_997200.1	Q6S9Z5	ZN474_HUMAN	zinc finger protein 474	208						intracellular	zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(10)|stomach(1)	21		all_cancers(142;0.229)|Prostate(80;0.0387)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000197)|Epithelial(69;0.00029)|all cancers(49;0.00415)		TCTTACTGGCCTCAAGAAAGC	0.488000													7	41					0.00198382	0.00223934	1	1	0
MIR521-1	574494	broad.mit.edu	37	19	54251917	54251917	+	RNA	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:54251917G>A	ENST00000384902.1	+	0	28					NR_030216.1																						CCAAAGGGAAGAACTTTCTGT	0.398000													6	140					0	0	1	0	0
IFT81	28981	broad.mit.edu	37	12	110600850	110600850	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:110600850G>A	ENST00000242591.5	+	11	1674	c.1168G>A	c.(1168-1170)Gaa>Aaa	p.E390K	IFT81_ENST00000361948.4_Missense_Mutation_p.E390K|IFT81_ENST00000552912.1_Missense_Mutation_p.E390K	NM_014055.3	NP_054774.2	Q8WYA0	IFT81_HUMAN	intraflagellar transport 81 homolog (Chlamydomonas)	390					cell differentiation|multicellular organismal development|spermatogenesis	intraflagellar transport particle B|microtubule-based flagellum				endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|stomach(1)	10						TGATGGTACTGAAGTTTTAAA	0.423000													8	61					0	0	1	0	0
OGDH	4967	broad.mit.edu	37	7	44736996	44736996	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:44736996G>C	ENST00000222673.5	+	16	2121	c.2079G>C	c.(2077-2079)caG>caC	p.Q693H	OGDH_ENST00000449767.1_Missense_Mutation_p.Q689H|OGDH_ENST00000444676.1_Missense_Mutation_p.Q708H|OGDH_ENST00000439616.2_Missense_Mutation_p.Q543H|OGDH_ENST00000543843.1_Missense_Mutation_p.Q644H|OGDH_ENST00000447398.1_Missense_Mutation_p.Q704H	NM_002541.3	NP_002532.2	Q02218	ODO1_HUMAN	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	693					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	36					NADH(DB00157)	TCCATGACCAGAATGTGGACA	0.542000													8	42					0	0	1	0	0
SPON1	10418	broad.mit.edu	37	11	14280960	14280960	+	RNA	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:14280960G>A	ENST00000310358.7	+	0	2162							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		GCTGCCCACTGAGGAAACGGA	0.672000													3	10					0	0	1	0	0
CLHC1	130162	broad.mit.edu	37	2	55407846	55407846	+	Missense_Mutation	SNP	A	A	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:55407846A>T	ENST00000401408.1	-	11	1529	c.1184T>A	c.(1183-1185)cTg>cAg	p.L395Q	CLHC1_ENST00000406076.1_Missense_Mutation_p.L273Q|CLHC1_ENST00000494539.1_Intron|CLHC1_ENST00000406437.2_5'UTR|CLHC1_ENST00000407122.1_Missense_Mutation_p.L395Q	NM_152385.2	NP_689598.2			clathrin heavy chain linker domain containing 1																		AGAAAATGTCAGTCTAGAACA	0.408000													5	30					0	0	1	0	0
KRTAP5-3	387266	broad.mit.edu	37	11	1629430	1629430	+	Silent	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:1629430G>T	ENST00000399685.1	-	1	263	c.186C>A	c.(184-186)ggC>ggA	p.G62G		NM_001012708.2	NP_001012726.1	Q6L8H2	KRA53_HUMAN	keratin associated protein 5-3	62	11 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(1)|large_intestine(2)|lung(3)|ovary(2)	8		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000618)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)		CCCCCTTGGAGCCCCCACAGG	0.677000													6	142					0.00198382	0.00223934	1	1	0
LRFN5	145581	broad.mit.edu	37	14	42355984	42355984	+	Missense_Mutation	SNP	A	A	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr14:42355984A>T	ENST00000554171.1	+	5	2588	c.156A>T	c.(154-156)agA>agT	p.R52S	LRFN5_ENST00000554120.1_Missense_Mutation_p.R52S|LRFN5_ENST00000298119.4_Missense_Mutation_p.R52S			Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	52						integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TTGACAGAAGAACTGTGGAAC	0.408000										HNSCC(30;0.082)			4	46					0	0	1	0	0
PHF20	51230	broad.mit.edu	37	20	34459028	34459028	+	Silent	SNP	G	G	C	rs139792522		TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr20:34459028G>C	ENST00000374012.3	+	8	1203	c.1074G>C	c.(1072-1074)acG>acC	p.T358T	PHF20_ENST00000439301.1_3'UTR|PHF20_ENST00000481202.1_3'UTR			Q9BVI0	PHF20_HUMAN	PHD finger protein 20	358					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			breast(5)|endometrium(1)|kidney(7)|large_intestine(6)|lung(11)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(12;0.00631)|all_lung(11;0.0145)					TGCAAGACACGTTGTCTAGTA	0.438000													11	85					0	0	1	0	0
FOCAD	54914	broad.mit.edu	37	9	20929356	20929356	+	Splice_Site	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr9:20929356G>A	ENST00000380249.1	+	29	3442		c.e29-1		FOCAD_ENST00000605086.1_Splice_Site|FOCAD_ENST00000338382.6_Splice_Site	NM_017794.3	NP_060264.3	Q5VW36	K1797_HUMAN	focadhesin							integral to membrane	binding										GCATGTCCTAGAAGTCCTATT	0.443000													23	56					0	0	1	0	0
RBP7	116362	broad.mit.edu	37	1	10068239	10068239	+	Silent	SNP	T	T	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:10068239T>C	ENST00000294435.7	+	3	304	c.261T>C	c.(259-261)gtT>gtC	p.V87V		NM_052960.2	NP_443192.1	Q96R05	RET7_HUMAN	retinol binding protein 7, cellular	87						cytoplasm	retinal binding|retinol binding|transporter activity			endometrium(1)|large_intestine(1)	2		all_lung(284;0.000407)|Renal(390;0.000469)|Lung NSC(185;0.000577)|Colorectal(325;0.0062)|Breast(348;0.00686)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.5e-08)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;0.000249)|BRCA - Breast invasive adenocarcinoma(304;0.000302)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00856)|READ - Rectum adenocarcinoma(331;0.0419)	Vitamin A(DB00162)	AGAGTTTGGTTATCTGGGACA	0.463000													4	53					0	0	1	0	0
SHPRH	257218	broad.mit.edu	37	6	146275900	146275900	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr6:146275900C>G	ENST00000367503.3	-	2	957	c.559G>C	c.(559-561)Gaa>Caa	p.E187Q	SHPRH_ENST00000367505.2_Missense_Mutation_p.E187Q|SHPRH_ENST00000275233.7_Missense_Mutation_p.E187Q|SHPRH_ENST00000438092.2_Missense_Mutation_p.E187Q	NM_001042683.2	NP_001036148.2	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	187					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(33)|ovary(3)|pancreas(2)|prostate(7)|skin(1)|urinary_tract(1)	79		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		CCCAAATCTTCTAACATTTCA	0.363000													5	69					0	0	1	0	0
CALB1	793	broad.mit.edu	37	8	91078188	91078188	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr8:91078188G>T	ENST00000265431.3	-	6	569	c.388C>A	c.(388-390)Ctg>Atg	p.L130M	CALB1_ENST00000518457.1_Missense_Mutation_p.L73M	NM_004929.2	NP_004920.1	P05937	CALB1_HUMAN	calbindin 1, 28kDa	130	EF-hand 3.					nucleus	calcium ion binding|vitamin D binding			breast(1)|kidney(1)|lung(8)|pancreas(1)	11			BRCA - Breast invasive adenocarcinoma(11;0.00953)			TTTTCTAGCAGGTCCTTTAGA	0.343000													3	26					0.00024832	0.000293427	1	1	0
SYNM	23336	broad.mit.edu	37	15	99669683	99669683	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr15:99669683C>T	ENST00000336292.6	+	5	1235	c.1115C>T	c.(1114-1116)gCa>gTa	p.A372V	SYNM_ENST00000328642.7_Missense_Mutation_p.A372V|RP11-6O2.4_ENST00000566974.1_RNA|SYNM_ENST00000561323.1_3'UTR|SYNM_ENST00000560674.1_Missense_Mutation_p.A87V	NM_145728.2	NP_663780.2	O15061	SYNEM_HUMAN	synemin, intermediate filament protein	373	Tail.				intermediate filament cytoskeleton organization	adherens junction|costamere|intermediate filament|neurofilament cytoskeleton	intermediate filament binding|structural constituent of cytoskeleton|structural constituent of muscle|vinculin binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(6)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	29						CACAGCTCGGCACTGTATTCT	0.473000													16	104					0	0	1	0	0
EMC8	10328	broad.mit.edu	37	16	85813424	85813424	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr16:85813424G>T	ENST00000253457.3	-	5	767	c.523C>A	c.(523-525)Ctg>Atg	p.L175M	EMC8_ENST00000435200.2_3'UTR	NM_006067.4	NP_006058.1			ER membrane protein complex subunit 8																		CGGCTGTCCAGGAGCGAGGCT	0.517000													4	28					0.150653	0.155077	1	1	0
DNM2	1785	broad.mit.edu	37	19	10883304	10883304	+	Splice_Site	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:10883304G>A	ENST00000314646.5	+	3	549	c.385G>A	c.(385-387)Gtg>Atg	p.V129M	DNM2_ENST00000389253.4_Splice_Site_p.V129M|DNM2_ENST00000359692.6_Splice_Site_p.V129M|DNM2_ENST00000408974.4_Splice_Site_p.V129M|DNM2_ENST00000585892.1_Splice_Site_p.V129M|DNM2_ENST00000355667.6_Splice_Site_p.V129M|DNM2_ENST00000591819.1_3'UTR			P50570	DYN2_HUMAN	dynamin 2	129					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	42			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			CTCGCCACACGGTAGGCAGCA	0.572000			"""F, N, Splice, Mis, O"""		ETP ALL								9	47					0	0	1	0	0
SCAI	286205	broad.mit.edu	37	9	127790711	127790711	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr9:127790711C>G	ENST00000336505.6	-	5	431	c.373G>C	c.(373-375)Gaa>Caa	p.E125Q	SCAI_ENST00000373549.4_Missense_Mutation_p.E148Q	NM_001144877.2	NP_001138349.1	Q8N9R8	SCAI_HUMAN	suppressor of cancer cell invasion		Necessary to inhibit MKL1-induced SRF transcriptional activity (By similarity).|Required for interaction with MKL1 (By similarity).				negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|integral to membrane|nucleus	protein binding|transcription corepressor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(7)|large_intestine(4)|lung(8)|ovary(2)|pancreas(1)|prostate(5)|stomach(1)|urinary_tract(1)	35						GAAGCAATTTCTCCTATTTGC	0.338000													8	78					0	0	1	0	0
KIDINS220	57498	broad.mit.edu	37	2	8888031	8888031	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:8888031G>C	ENST00000256707.3	-	25	3695	c.3514C>G	c.(3514-3516)Cag>Gag	p.Q1172E	KIDINS220_ENST00000473731.1_Missense_Mutation_p.Q1172E|KIDINS220_ENST00000427284.1_Missense_Mutation_p.Q1172E|KIDINS220_ENST00000418530.1_Intron	NM_020738.2	NP_065789.1	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate, 220kDa	1172					activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(25)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	60	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CCATTGTTCTGATCTCTGGGC	0.388000													9	39					0	0	1	0	0
DHX58	79132	broad.mit.edu	37	17	40255715	40255715	+	Silent	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:40255715G>C	ENST00000251642.3	-	12	1887	c.1665C>G	c.(1663-1665)ctC>ctG	p.L555L		NM_024119.2	NP_077024.2	Q96C10	DHX58_HUMAN	DEXH (Asp-Glu-X-His) box polypeptide 58	555					innate immune response	cytoplasm	ATP binding|DNA binding|helicase activity|protein binding|RNA binding|zinc ion binding			breast(2)|endometrium(3)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_cancers(22;9.73e-07)|all_epithelial(22;3.58e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		AGTTGATGCAGAGTAGCTGCA	0.637000													5	33					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154227852	154227852	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:154227852G>C	ENST00000360256.4	-	2	367	c.167C>G	c.(166-168)tCt>tGt	p.S56C		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	56	F5/8 type A 1.|Plastocyanin-like 1.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	GAATGGAAAAGATTTTGGCAC	0.433000													18	106					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43881758	43881758	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:43881758C>T	ENST00000562955.1	+	6	758	c.758C>T	c.(757-759)tCg>tTg	p.S253L		NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	253						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						TTACTACCCTCGAACTCTAGT	0.542000													3	23					0	0	1	0	0
NGEF	25791	broad.mit.edu	37	2	233759485	233759485	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:233759485C>A	ENST00000264051.3	-	6	1248	c.970G>T	c.(970-972)Gtg>Ttg	p.V324L	NGEF_ENST00000409079.1_Missense_Mutation_p.V232L|NGEF_ENST00000539537.1_Missense_Mutation_p.V47L|NGEF_ENST00000373552.4_Missense_Mutation_p.V232L	NM_019850.2	NP_062824.2	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	324	DH.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(4)|endometrium(8)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|skin(4)	35		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		ACAGCCAGCACGTCCAGGACG	0.602000													7	29					0.00198382	0.00223934	1	1	0
ZNF304	57343	broad.mit.edu	37	19	57867966	57867966	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:57867966G>A	ENST00000391705.3	+	4	1013	c.729G>A	c.(727-729)atG>atA	p.M243I	ZNF304_ENST00000282286.5_Missense_Mutation_p.M243I|ZNF304_ENST00000598744.1_Missense_Mutation_p.M201I|ZNF304_ENST00000443917.2_Missense_Mutation_p.M290I	NM_020657.2	NP_065708.2	Q9HCX3	ZN304_HUMAN	zinc finger protein 304	243					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)	26		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		ACAGCCAGATGACTCATGCTG	0.453000													7	56					0	0	1	0	0
LINC00922	283867	broad.mit.edu	37	16	65345320	65345320	+	RNA	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr16:65345320C>T	ENST00000569736.1	-	0	815				RP11-256I9.3_ENST00000562656.1_lincRNA	NR_027755.1																						TACTCACCTTCGTGAGTGAAG	0.413000													6	51					0	0	1	0	0
ZNF652	22834	broad.mit.edu	37	17	47394286	47394286	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:47394286G>C	ENST00000362063.2	-	2	1120	c.802C>G	c.(802-804)Cat>Gat	p.H268D	ZNF652_ENST00000430262.2_Missense_Mutation_p.H268D	NM_014897.2	NP_055712.1	Q9Y2D9	ZN652_HUMAN	zinc finger protein 652	268					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	20	all_cancers(4;6.81e-14)|Breast(4;4.97e-29)|all_epithelial(4;1.53e-17)		BRCA - Breast invasive adenocarcinoma(1;3.1e-14)|Epithelial(5;2.92e-06)|all cancers(6;3.15e-05)			ATGCGCCTATGAGTAACGTTC	0.458000													9	56					0	0	1	0	0
OR51V1	283111	broad.mit.edu	37	11	5221635	5221635	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:5221635C>G	ENST00000321255.1	-	1	295	c.296G>C	c.(295-297)cGa>cCa	p.R99P		NM_001004760.2	NP_001004760.2	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V, member 1	99					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(13)|lung(19)|skin(2)|upper_aerodigestive_tract(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCTGATCTCTCGAATGATCCC	0.537000													12	28					0	0	1	0	0
NUP160	23279	broad.mit.edu	37	11	47808015	47808015	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:47808015T>C	ENST00000378460.2	-	32	3884	c.3838A>G	c.(3838-3840)Aag>Gag	p.K1280E	NUP160_ENST00000530326.1_Missense_Mutation_p.K1166E	NM_015231.1	NP_056046.1	Q12769	NU160_HUMAN	nucleoporin 160kDa	1280					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|biliary_tract(2)|breast(7)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(6)|prostate(2)|skin(2)|urinary_tract(2)	53						CTAGACTCCTTAGTAGTGATG	0.453000													9	23					0	0	1	0	0
CCDC153	283152	broad.mit.edu	37	11	119061132	119061132	+	Silent	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:119061132C>G	ENST00000503566.2	-	6	509	c.510G>C	c.(508-510)ctG>ctC	p.L170L	CCDC153_ENST00000415318.1_Silent_p.L170L			Q494R4	CC153_HUMAN	coiled-coil domain containing 153	170										lung(3)|stomach(1)	4						TGATGGCTCTCAGCTTGGCCA	0.567000													8	46					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55538695	55538695	+	Silent	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr8:55538695C>A	ENST00000220676.1	+	4	2401	c.2253C>A	c.(2251-2253)tcC>tcA	p.S751S		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	751					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ATCTCAATTCCACGATTTCCA	0.308000													9	46					0.000274275	0.000320496	1	1	0
CADM4	199731	broad.mit.edu	37	19	44127515	44127515	+	Missense_Mutation	SNP	G	G	T	rs144737031		TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:44127515G>T	ENST00000222374.2	-	9	1182	c.1134C>A	c.(1132-1134)gaC>gaA	p.D378E		NM_145296.1	NP_660339.1	Q8NFZ8	CADM4_HUMAN	cell adhesion molecule 4	378					cell adhesion	integral to membrane		p.D378D(1)		endometrium(2)|large_intestine(3)|lung(4)|prostate(1)|skin(2)	12		Prostate(69;0.0199)				TCTTGTGTCCGTCGCTGCCAT	0.612000													11	156					4.68919e-08	6.32239e-08	1	1	0
CHI3L2	1117	broad.mit.edu	37	1	111773888	111773888	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:111773888A>G	ENST00000445067.2	+	6	1072	c.301A>G	c.(301-303)Att>Gtt	p.I101V	CHI3L2_ENST00000369744.2_Missense_Mutation_p.I91V|CHI3L2_ENST00000524472.1_Missense_Mutation_p.I22V|CHI3L2_ENST00000369748.4_Missense_Mutation_p.I101V|CHI3L2_ENST00000466741.1_Missense_Mutation_p.I22V			Q15782	CH3L2_HUMAN	chitinase 3-like 2	101					chitin catabolic process	extracellular space	cation binding|chitinase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(8)|prostate(1)	19		all_cancers(81;1.89e-05)|all_epithelial(167;7.36e-06)|all_lung(203;0.00018)|Lung NSC(277;0.000359)		Lung(183;0.0171)|Colorectal(144;0.0387)|all cancers(265;0.0464)|LUSC - Lung squamous cell carcinoma(189;0.0872)|Epithelial(280;0.0994)|COAD - Colon adenocarcinoma(174;0.141)		TCTCTTGTCCATTGGAGGGTA	0.363000													7	61					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79086861	79086861	+	Missense_Mutation	SNP	A	A	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:79086861A>T	ENST00000446378.2	+	11	11789	c.11758A>T	c.(11758-11760)Atc>Ttc	p.I3920F	CTC-431G16.2_ENST00000421252.2_RNA	NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	3920	B30.2/SPRY.					perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TGGGACAGTGATCAGCTTTGG	0.473000													6	22					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578493	7578493	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:7578493C>T	ENST00000420246.2	-	5	569	c.437G>A	c.(436-438)tGg>tAg	p.W146*	TP53_ENST00000269305.4_Nonsense_Mutation_p.W146*|TP53_ENST00000455263.2_Nonsense_Mutation_p.W146*|TP53_ENST00000413465.2_Nonsense_Mutation_p.W146*|TP53_ENST00000445888.2_Nonsense_Mutation_p.W146*|TP53_ENST00000359597.4_Nonsense_Mutation_p.W146*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	146	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		W -> C (in a sporadic cancer; somatic mutation).|W -> G (in sporadic cancers; somatic mutation).|W -> L (in sporadic cancers; somatic mutation).|W -> R (in sporadic cancers; somatic mutation).|W -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.W146*(33)|p.0?(8)|p.W146S(4)|p.Q144_G154del11(1)|p.L137_W146del10(1)|p.Q144fs*32(1)|p.W14S(1)|p.Q144fs*16(1)|p.W146fs*1(1)|p.W146fs*22(1)|p.W146fs*23(1)|p.W53S(1)|p.V143_S149del(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGAATCAACCCACAGCTGCAC	0.602000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			6	23					0	0	1	0	0
USP11	8237	broad.mit.edu	37	X	47101874	47101874	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:47101874G>C	ENST00000377107.2	+	11	1795	c.1441G>C	c.(1441-1443)Gat>Cat	p.D481H	USP11_ENST00000218348.3_Missense_Mutation_p.D524H			P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	524					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|ovary(3)|pancreas(1)|stomach(1)	40						CAAGATCTCGGATCTATGTGT	0.542000													3	38					0	0	1	0	0
WIPF1	7456	broad.mit.edu	37	2	175436616	175436616	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:175436616G>A	ENST00000392547.2	-	5	1016	c.917C>T	c.(916-918)gCc>gTc	p.A306V	WIPF1_ENST00000409415.3_Missense_Mutation_p.A306V|AC018890.6_ENST00000412835.1_RNA|WIPF1_ENST00000359761.3_Missense_Mutation_p.A306V|WIPF1_ENST00000272746.5_Missense_Mutation_p.A306V|AC018890.6_ENST00000442996.1_RNA|WIPF1_ENST00000409891.1_Missense_Mutation_p.A306V|WIPF1_ENST00000392546.2_Missense_Mutation_p.A306V	NM_003387.4	NP_003378.3	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	306	Pro-rich.				actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			NS(1)|breast(1)|endometrium(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)	32						CGGAGGTGGGGCCTGTGAGGA	0.662000													5	14					0	0	1	0	0
APOH	350	broad.mit.edu	37	17	64212966	64212966	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:64212966C>A	ENST00000205948.6	-	6	761	c.724G>T	c.(724-726)Ggc>Tgc	p.G242C		NM_000042.2	NP_000033.2	P02749	APOH_HUMAN	apolipoprotein H (beta-2-glycoprotein I)	242	Sushi 4.				blood coagulation, intrinsic pathway|negative regulation of angiogenesis|negative regulation of blood coagulation|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of myeloid cell apoptosis|negative regulation of smooth muscle cell apoptosis|plasminogen activation|positive regulation of lipoprotein lipase activity|triglyceride metabolic process|triglyceride transport	cell surface|chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	eukaryotic cell surface binding|glycoprotein binding|heparin binding|lipoprotein lipase activator activity|phospholipid binding			central_nervous_system(1)|kidney(3)|large_intestine(5)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17			BRCA - Breast invasive adenocarcinoma(6;9.74e-08)			TCTTCCGGGCCATCCAGAGAA	0.418000													4	78					0.150653	0.155077	1	1	0
METTL21B	25895	broad.mit.edu	37	12	58174199	58174199	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:58174199G>A	ENST00000300209.8	+	3	576	c.451G>A	c.(451-453)Gat>Aat	p.D151N	METTL21B_ENST00000551420.1_5'UTR|RP11-571M6.15_ENST00000471530.1_Intron|RP11-571M6.15_ENST00000553083.1_Intron|METTL21B_ENST00000548256.1_3'UTR|METTL21B_ENST00000333012.5_3'UTR	NM_015433.2	NP_056248.2	Q96AZ1	MT21B_HUMAN	methyltransferase like 21B	151						integral to membrane|intracellular	methyltransferase activity			endometrium(1)|lung(1)	2						GCTGGGGGCTGATATCGTGTA	0.597000													6	35					0	0	1	0	0
CCNA1	8900	broad.mit.edu	37	13	37011791	37011791	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr13:37011791C>T	ENST00000418263.1	+	3	670	c.320C>T	c.(319-321)tCt>tTt	p.S107F	CCNA1_ENST00000449823.1_Missense_Mutation_p.S64F|CCNA1_ENST00000440264.1_Missense_Mutation_p.S64F|CCNA1_ENST00000255465.4_Missense_Mutation_p.S108F|CCNA1_ENST00000463403.1_3'UTR	NM_001111045.1|NM_003914.3	NP_001104515.1|NP_003905.1	P78396	CCNA1_HUMAN	cyclin A1	108					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(2)|urinary_tract(1)	35		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		AGGTGTTATTCTGGATCAGAA	0.463000													7	77					0	0	1	0	0
KIAA1033	23325	broad.mit.edu	37	12	105519872	105519872	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:105519872C>T	ENST00000332180.5	+	11	964	c.877C>T	c.(877-879)Cgg>Tgg	p.R293W		NM_015275.1	NP_056090.1	Q2M389	WAHS7_HUMAN	KIAA1033	293				R -> Q (in Ref. 2; BAA91816).	endosome transport	WASH complex				breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	41						ACATAGTATTCGGTCAATTTT	0.323000													11	40					0	0	1	0	0
TP53I3	9540	broad.mit.edu	37	2	24305843	24305843	+	Silent	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:24305843G>T	ENST00000238721.4	-	2	1172	c.318C>A	c.(316-318)ctC>ctA	p.L106L	TP53I3_ENST00000407482.1_Silent_p.L106L|FAM228B_ENST00000461972.1_Intron|TP53I3_ENST00000335934.4_Silent_p.L106L|TP53I3_ENST00000313482.4_Silent_p.L106L|TP53I3_ENST00000417886.1_Intron	NM_004881.4	NP_004872.2	Q53FA7	QORX_HUMAN	tumor protein p53 inducible protein 3	106					induction of apoptosis by oxidative stress|NADP metabolic process		NADPH binding|NADPH:quinone reductase activity|protein homodimerization activity|quinone binding|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(2)|lung(3)|urinary_tract(2)	12	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGATAGGCATGAGGAGCCCTT	0.647000													4	14					0.00909568	0.00992971	1	1	0
OR2F2	135948	broad.mit.edu	37	7	143632727	143632727	+	Silent	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:143632727C>A	ENST00000408955.2	+	1	469	c.402C>A	c.(400-402)gcC>gcA	p.A134A		NM_001004685.1	NP_001004685.1	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F, member 2	134					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(19)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	32	Melanoma(164;0.0903)					GATACTCGGCCATCATGCATG	0.552000													8	68					5.18039e-06	6.60369e-06	1	1	0
PLXNA3	55558	broad.mit.edu	37	X	153696528	153696528	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:153696528C>G	ENST00000369682.3	+	22	4099	c.3924C>G	c.(3922-3924)ttC>ttG	p.F1308L		NM_017514.3	NP_059984.3	P51805	PLXA3_HUMAN	plexin A3	1308					axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCGTGCTCTTCCCGGGCATCG	0.637000													3	43					0	0	1	0	0
WDR53	348793	broad.mit.edu	37	3	196281322	196281322	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:196281322C>G	ENST00000332629.5	-	4	1404	c.837G>C	c.(835-837)aaG>aaC	p.K279N	WDR53_ENST00000433160.1_Missense_Mutation_p.K120N|WDR53_ENST00000429115.1_Missense_Mutation_p.K118N	NM_182627.1	NP_872433.1	Q7Z5U6	WDR53_HUMAN	WD repeat domain 53	279										breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)	13	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.6e-23)|all cancers(36;1.54e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.29e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		TTGTGGGACTCTTCTGTTTTT	0.448000													4	72					0	0	1	0	0
CEP128	145508	broad.mit.edu	37	14	81251718	81251718	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr14:81251718C>G	ENST00000555265.1	-	15	2107	c.1732G>C	c.(1732-1734)Gaa>Caa	p.E578Q	CEP128_ENST00000281129.3_Missense_Mutation_p.E578Q			Q6ZU80	CE128_HUMAN	centrosomal protein 128kDa	578						centriole|spindle pole				NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	51						ACTTCCAATTCAAGGTCAGCT	0.428000													9	72					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108147351	108147351	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:108147351C>G	ENST00000273353.3	-	28	3806	c.3750G>C	c.(3748-3750)atG>atC	p.M1250I		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1250						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						TAGCTCTTGTCATCTGCTCAA	0.478000													25	111					0	0	1	0	0
DGKB	1607	broad.mit.edu	37	7	14188815	14188815	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:14188815G>T	ENST00000403951.2	-	26	2775	c.2356C>A	c.(2356-2358)Cca>Aca	p.P786T	DGKB_ENST00000444700.2_Missense_Mutation_p.P767T|DGKB_ENST00000258767.5_Missense_Mutation_p.P786T|DGKB_ENST00000402815.1_Missense_Mutation_p.P785T|DGKB_ENST00000407950.1_Missense_Mutation_p.P778T|DGKB_ENST00000399322.3_Missense_Mutation_p.P786T			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	786					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	CCGGTTTTTGGAGGCGGGCCC	0.393000													8	83					0.000157383	0.000187375	1	1	0
ABCA8	10351	broad.mit.edu	37	17	66899531	66899531	+	Silent	SNP	A	A	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:66899531A>C	ENST00000269080.2	-	18	2525	c.2388T>G	c.(2386-2388)ggT>ggG	p.G796G	ABCA8_ENST00000586539.1_Silent_p.G836G|ABCA8_ENST00000430352.2_Silent_p.G836G	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	796						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					GAGCCACACCACCTATTGTCT	0.428000													16	105					0	0	1	0	0
MSL3	10943	broad.mit.edu	37	X	11783671	11783671	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:11783671C>G	ENST00000337339.2	+	9	1021	c.994C>G	c.(994-996)Cca>Gca	p.P332A	MSL3_ENST00000398527.2_Missense_Mutation_p.P320A|MSL3_ENST00000361672.2_Missense_Mutation_p.P183A|MSL3_ENST00000380693.3_Missense_Mutation_p.P166A|MSL3_ENST00000312196.4_Missense_Mutation_p.P332A	NM_078628.1	NP_523352.1	Q8N5Y2	MS3L1_HUMAN	male-specific lethal 3 homolog (Drosophila)	332					histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(3)|cervix(1)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|urinary_tract(1)	19						CACCGGTGAACCAGCCACCCC	0.592000													5	81					0	0	1	0	0
TACO1	51204	broad.mit.edu	37	17	61684733	61684733	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:61684733T>C	ENST00000258975.6	+	4	814	c.602T>C	c.(601-603)gTg>gCg	p.V201A		NM_016360.3	NP_057444.2	Q9BSH4	TACO1_HUMAN	translational activator of mitochondrially encoded cytochrome c oxidase I	201					regulation of translation	mitochondrion				breast(2)|endometrium(1)|lung(1)	4						AAGAAGGCTGTGAACCTAGAG	0.483000													5	27					0	0	1	0	0
KLHL3	26249	broad.mit.edu	37	5	136993882	136993882	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:136993882C>A	ENST00000508657.1	-	8	1459	c.745G>T	c.(745-747)Gat>Tat	p.D249Y	KLHL3_ENST00000309755.4_Missense_Mutation_p.D281Y|KLHL3_ENST00000506491.1_Missense_Mutation_p.D199Y|KLHL3_ENST00000394937.3_Missense_Mutation_p.D281Y|KLHL3_ENST00000541417.1_Missense_Mutation_p.D161Y|KLHL3_ENST00000506873.1_5'UTR	NM_001257194.1	NP_001244123.1	Q9UH77	KLHL3_HUMAN	kelch-like family member 3	281						cytoplasm|cytoskeleton	actin binding|structural molecule activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|stomach(1)|upper_aerodigestive_tract(1)	21		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		AGTCTCTGATCCAGAGGGAGG	0.468000													7	34					0.0381472	0.0402523	1	1	0
SLC23A1	9963	broad.mit.edu	37	5	138707768	138707768	+	Nonsense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:138707768G>C	ENST00000353963.3	-	14	1774	c.1736C>G	c.(1735-1737)tCa>tGa	p.S579*	SLC23A1_ENST00000348729.3_Nonsense_Mutation_p.S575*	NM_152685.3	NP_689898	Q9UHI7	S23A1_HUMAN	solute carrier family 23 (ascorbic acid transporter), member 1	575					brain development|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|response to toxin|transepithelial L-ascorbic acid transport|water-soluble vitamin metabolic process	apical plasma membrane|cytoplasm|integral to plasma membrane|intracellular organelle|membrane fraction	dehydroascorbic acid transporter activity|L-ascorbate:sodium symporter activity|nucleobase transmembrane transporter activity|protein binding|sodium-dependent L-ascorbate transmembrane transporter activity			biliary_tract(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(5)|ovary(1)	19			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)		Vitamin C(DB00126)	CTGATCTTTTGAACTTGAAGA	0.398000													14	104					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88966097	88966097	+	Silent	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:88966097C>G	ENST00000333190.4	+	4	4410	c.3801C>G	c.(3799-3801)ccC>ccG	p.P1267P		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1267						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CAGGTCATCCCCTGCATTTAG	0.463000										HNSCC(36;0.09)			9	79					0	0	1	0	0
ZNF669	79862	broad.mit.edu	37	1	247263885	247263885	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:247263885C>T	ENST00000343381.6	-	4	1358	c.1186G>A	c.(1186-1188)Gat>Aat	p.D396N	ZNF669_ENST00000448299.2_Missense_Mutation_p.D310N|ZNF669_ENST00000358785.4_3'UTR	NM_024804.2	NP_079080.2	Q96BR6	ZN669_HUMAN	zinc finger protein 669	396					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(4)|large_intestine(2)|lung(6)	17	all_cancers(71;4.09e-05)|all_epithelial(71;6.72e-06)|Breast(184;0.0226)|Ovarian(71;0.0283)|all_lung(81;0.0488)|Lung NSC(105;0.053)		OV - Ovarian serous cystadenocarcinoma(106;0.00427)			AAGGCTTGATCACATTGTTTA	0.423000													7	102					0	0	1	0	0
KLHL30	377007	broad.mit.edu	37	2	239049543	239049543	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:239049543C>A	ENST00000409223.1	+	2	255	c.148C>A	c.(148-150)Ctc>Atc	p.L50I	KLHL30_ENST00000305959.4_Missense_Mutation_p.L32I			Q0D2K2	KLH30_HUMAN	kelch-like family member 30	50	BTB.									lung(4)	4		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		CCACCGCGGCCTCCTGGCGCT	0.697000													7	28					8.12818e-05	9.75073e-05	1	1	0
EPC1	80314	broad.mit.edu	37	10	32562144	32562144	+	Missense_Mutation	SNP	C	C	T	rs150143347		TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr10:32562144C>T	ENST00000319778.6	-	11	2112	c.1810G>A	c.(1810-1812)Gca>Aca	p.A604T	EPC1_ENST00000263062.8_Missense_Mutation_p.A604T|EPC1_ENST00000375110.2_Missense_Mutation_p.A554T	NM_001272004.1|NM_001272019.2	NP_001258933.1|NP_001258948.1	Q9H2F5	EPC1_HUMAN	enhancer of polycomb homolog 1 (Drosophila)	604					histone H2A acetylation|histone H4 acetylation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear membrane|Piccolo NuA4 histone acetyltransferase complex				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(8)|ovary(5)|urinary_tract(1)	24		Prostate(175;0.0199)				TGAATTTGTGCAAGCTGCTGT	0.398000													6	49					0	0	1	0	0
FFAR3	2865	broad.mit.edu	37	19	35850582	35850582	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:35850582C>T	ENST00000327809.4	+	2	991	c.790C>T	c.(790-792)Ctc>Ttc	p.L264F	FFAR3_ENST00000594310.1_Missense_Mutation_p.L264F	NM_005304.3	NP_005295.1	O14843	FFAR3_HUMAN	free fatty acid receptor 3	264						integral to plasma membrane	G-protein coupled receptor activity|lipid binding			endometrium(3)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|stomach(1)	17	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;1.29e-19)|OV - Ovarian serous cystadenocarcinoma(14;4.63e-18)|all cancers(14;5.19e-17)|LUSC - Lung squamous cell carcinoma(66;0.0221)			CGTGACGCTTCTCAGCACCCT	0.567000													22	140					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101830865	101830865	+	Nonsense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr9:101830865C>G	ENST00000375001.3	+	41	4289	c.3866C>G	c.(3865-3867)tCa>tGa	p.S1289*		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	1289	Nonhelical region 10 (NC10).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				AATTGGGACTCAATTTTTTCT	0.363000													3	73					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29559841	29559841	+	Silent	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:29559841C>A	ENST00000358273.4	+	26	3821	c.3438C>A	c.(3436-3438)gtC>gtA	p.V1146V	NF1_ENST00000356175.3_Silent_p.V1146V	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	1146					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(4)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		ACTGTACGGTCCTTGCAATGT	0.448000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			8	31					0.00307968	0.00345779	1	1	0
OR1L4	254973	broad.mit.edu	37	9	125486319	125486319	+	Silent	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr9:125486319C>A	ENST00000259466.1	+	1	51	c.51C>A	c.(49-51)ggC>ggA	p.G17G		NM_001005235.1	NP_001005235.1	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L, member 4	17					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(3)|lung(13)|prostate(1)|skin(1)	20						TCCTCCTGGGCCTCTCTTCCA	0.498000													7	80					0.00198382	0.00223934	1	1	0
FLRT3	23767	broad.mit.edu	37	20	14306971	14306971	+	Silent	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr20:14306971G>T	ENST00000378053.3	-	2	1438	c.1182C>A	c.(1180-1182)ccC>ccA	p.P394P	MACROD2_ENST00000217246.4_Intron|MACROD2_ENST00000310348.4_Intron|FLRT3_ENST00000341420.4_Silent_p.P394P	NM_013281.3	NP_037413.1	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	394					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity	p.P394P(1)		breast(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		TAGTGAGCTTGGGGTTCTTAA	0.453000													12	161					9.31168e-06	1.17985e-05	1	1	0
ITGA6	3655	broad.mit.edu	37	2	173356018	173356018	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:173356018C>G	ENST00000375221.2	+	23	3168	c.2965C>G	c.(2965-2967)Ctt>Gtt	p.L989V	ITGA6_ENST00000264106.6_Missense_Mutation_p.L989V|ITGA6_ENST00000409080.1_Missense_Mutation_p.L950V|ITGA6_ENST00000343713.4_Missense_Mutation_p.L945V|ITGA6_ENST00000409532.1_Missense_Mutation_p.L831V|ITGA6_ENST00000264107.7_Missense_Mutation_p.L950V|AC093818.1_ENST00000442417.1_RNA			P23229	ITA6_HUMAN	integrin, alpha 6	989					blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	44			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			CAAGGCGTCTCTTATTTTGCG	0.478000													20	80					0	0	1	0	0
TRIM39	56658	broad.mit.edu	37	6	30297321	30297321	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr6:30297321G>A	ENST00000376659.5	+	3	825	c.227G>A	c.(226-228)cGc>cAc	p.R76H	TRIM39_ENST00000396551.3_Missense_Mutation_p.R76H|TRIM39_ENST00000396547.1_Missense_Mutation_p.R76H|TRIM39_ENST00000540416.1_Missense_Mutation_p.R76H|TRIM39_ENST00000376656.4_Missense_Mutation_p.R76H|TRIM39_ENST00000396548.1_Missense_Mutation_p.R76H	NM_172016.2	NP_742013.1			tripartite motif containing 39											ovary(3)	3						TCCCGCTACCGCAGTCTCCGA	0.577000													11	31					0	0	1	0	0
VILL	50853	broad.mit.edu	37	3	38038627	38038627	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:38038627G>C	ENST00000283713.6	+	6	776	c.510G>C	c.(508-510)aaG>aaC	p.K170N	VILL_ENST00000383759.2_Missense_Mutation_p.K170N|VILL_ENST00000465644.1_Intron			O15195	VILL_HUMAN	villin-like	170					actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|liver(1)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|stomach(3)|urinary_tract(2)	28				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		ACCTAGGCAAGATGATGATTC	0.557000											OREG0015474	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	63					0	0	1	0	0
IGKV1-33	28933	broad.mit.edu	37	2	89568222	89568222	+	RNA	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:89568222C>A	ENST00000473726.1	-	0	41																											AGCAGGGACCCTCATGTCCAT	0.567000													3	34					0.00116845	0.00133567	1	1	0
SLC26A3	1811	broad.mit.edu	37	7	107427288	107427288	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:107427288C>A	ENST00000340010.5	-	8	1139	c.955G>T	c.(955-957)Ggg>Tgg	p.G319W	SLC26A3_ENST00000422236.2_Missense_Mutation_p.G284W	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	319					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						TTCATGTCCCCAACCACAGCC	0.468000													11	61					0.000978159	0.00112426	1	1	0
COL7A1	1294	broad.mit.edu	37	3	48630676	48630676	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:48630676C>G	ENST00000328333.8	-	5	648	c.541G>C	c.(541-543)Gag>Cag	p.E181Q	COL7A1_ENST00000454817.1_Missense_Mutation_p.E181Q	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	181	Nonhelical region (NC1).|VWFA 1.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TTCAGCTCCTCAGGGTCAGCA	0.567000													8	40					0	0	1	0	0
POF1B	79983	broad.mit.edu	37	X	84560834	84560834	+	Nonsense_Mutation	SNP	A	A	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:84560834A>T	ENST00000262753.4	-	13	1545	c.1400T>A	c.(1399-1401)tTg>tAg	p.L467*	POF1B_ENST00000373145.3_Nonsense_Mutation_p.L467*	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	467							actin binding			central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)	35						CTCCATTCTCAAGTTTTTTAC	0.408000													5	61					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9578093	9578093	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:9578093G>T	ENST00000301480.4	-	10	1743	c.1530C>A	c.(1528-1530)caC>caA	p.H510Q		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	510					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						TCTCACCAGTGTGAGTTCTCA	0.413000													20	60					0.000958276	0.00110342	1	1	0
POR	5447	broad.mit.edu	37	7	75615554	75615554	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:75615554C>G	ENST00000419840.1	+	14	1635	c.995C>G	c.(994-996)tCt>tGt	p.S332C	POR_ENST00000439269.1_Silent_p.V369V|POR_ENST00000450476.1_Silent_p.V530V|POR_ENST00000394893.1_Silent_p.V631V|POR_ENST00000545601.1_Silent_p.V439V|POR_ENST00000461988.1_Silent_p.V631V			P16435	NCPR_HUMAN	P450 (cytochrome) oxidoreductase	0	FAD-binding FR-type.				cellular organofluorine metabolic process|positive regulation of monooxygenase activity	endoplasmic reticulum membrane	iron ion binding|NADPH-hemoprotein reductase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|lung(3)|ovary(1)	9					Benzphetamine(DB00865)|Daunorubicin(DB00694)|Lipoic Acid(DB00166)|Menadione(DB00170)|Methoxyflurane(DB01028)|Mitomycin(DB00305)|Nilutamide(DB00665)	ACATCTACGTCTGTGGGTGAG	0.632000													4	13					0	0	1	0	0
COMTD1	118881	broad.mit.edu	37	10	76993840	76993840	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr10:76993840G>C	ENST00000372538.3	-	7	862	c.780C>G	c.(778-780)ttC>ttG	p.F260L	COMTD1_ENST00000460899.1_5'UTR	NM_144589.2	NP_653190.2	Q86VU5	CMTD1_HUMAN	catechol-O-methyltransferase domain containing 1	260						integral to membrane	O-methyltransferase activity			central_nervous_system(1)|large_intestine(1)|lung(1)	3	all_cancers(46;0.0642)|all_epithelial(25;0.00604)|Prostate(51;0.0112)|Ovarian(15;0.183)					CCTAGATCTTGAAGGCCAAGG	0.582000													3	46					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150923959	150923959	+	Silent	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:150923959G>C	ENST00000261800.5	-	9	6741	c.6729C>G	c.(6727-6729)gtC>gtG	p.V2243V		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	2243	Cadherin 19.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCGTGGCTCTGACTGTGAACA	0.478000													11	72					0	0	1	0	0
PARP15	165631	broad.mit.edu	37	3	122345780	122345780	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:122345780C>T	ENST00000464300.2	+	9	1404	c.1338C>T	c.(1336-1338)gtC>gtT	p.V446V	PARP15_ENST00000465304.1_3'UTR|PARP15_ENST00000483793.1_Intron|PARP15_ENST00000310366.4_Silent_p.V212V|PARP15_ENST00000493645.1_Intron	NM_001113523.1	NP_001106995.1	Q460N3	PAR15_HUMAN	poly (ADP-ribose) polymerase family, member 15	424					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	NAD+ ADP-ribosyltransferase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	24				GBM - Glioblastoma multiforme(114;0.0531)		TTAAAGTTGTCATTTTTCAAC	0.378000													7	56					0	0	1	0	0
MATN4	8785	broad.mit.edu	37	20	43926963	43926963	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr20:43926963C>A	ENST00000537548.1	-	8	1517	c.1273G>T	c.(1273-1275)Ggg>Tgg	p.G425W	MATN4_ENST00000342716.4_Missense_Mutation_p.G425W|MATN4_ENST00000372751.4_Missense_Mutation_p.G276W|MATN4_ENST00000353917.5_Missense_Mutation_p.G343W|MATN4_ENST00000372754.1_Missense_Mutation_p.G466W|MATN4_ENST00000372756.1_Missense_Mutation_p.G425W|MATN4_ENST00000360607.6_Missense_Mutation_p.G384W			O95460	MATN4_HUMAN	matrilin 4	466	VWFA 2.					extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.0122)				AACGCCAGCCCTGTCATGGTG	0.677000													5	28					0.184627	0.188511	1	1	0
ST5	6764	broad.mit.edu	37	11	8752224	8752224	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:8752224C>G	ENST00000534127.1	-	6	998	c.613G>C	c.(613-615)Ggc>Cgc	p.G205R	ST5_ENST00000530438.1_Intron|ST5_ENST00000313726.6_Missense_Mutation_p.G205R|ST5_ENST00000357665.1_Missense_Mutation_p.G205R|ST5_ENST00000526757.1_Intron	NM_005418.3	NP_005409.3	P78524	ST5_HUMAN	suppression of tumorigenicity 5	205					positive regulation of ERK1 and ERK2 cascade		protein binding			NS(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(13)|liver(1)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	39				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		CTGGGACAGCCCAGGCTGGGG	0.652000													8	16					0	0	1	0	0
SLC25A30	253512	broad.mit.edu	37	13	45975264	45975264	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr13:45975264G>A	ENST00000539591.1	-	6	578	c.415C>T	c.(415-417)Ctt>Ttt	p.L139F				Q5SVS4	KMCP1_HUMAN	solute carrier family 25, member 30	190					mitochondrial transport	integral to membrane|mitochondrial inner membrane	binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	9		Lung NSC(96;0.00227)|Prostate(109;0.00578)|Breast(56;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.95e-05)		GAGAGAATAAGATGCTTCTTG	0.398000													7	49					0	0	1	0	0
FAM129C	199786	broad.mit.edu	37	19	17653056	17653056	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:17653056C>G	ENST00000335393.4	+	11	1513	c.1375C>G	c.(1375-1377)Ctg>Gtg	p.L459V	FAM129C_ENST00000599124.1_Missense_Mutation_p.L428V|FAM129C_ENST00000599164.1_Missense_Mutation_p.L428V|FAM129C_ENST00000595684.1_Missense_Mutation_p.L459V|FAM129C_ENST00000601861.1_Missense_Mutation_p.L428V|FAM129C_ENST00000332386.5_Missense_Mutation_p.L459V|FAM129C_ENST00000300971.2_Missense_Mutation_p.L459V|FAM129C_ENST00000449408.2_Missense_Mutation_p.L185V|FAM129C_ENST00000600871.1_Missense_Mutation_p.L405V|FAM129C_ENST00000352727.3_Missense_Mutation_p.L459V	NM_173544.4	NP_775815	Q86XR2	NIBL2_HUMAN	family with sequence similarity 129, member C	459										autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(2)|lung(14)|ovary(1)|skin(3)|stomach(1)	33						GTTTGGCTTTCTGGGGATGCA	0.642000													18	77					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141459386	141459386	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:141459386C>A	ENST00000389484.3	-	40	7302	c.6331G>T	c.(6331-6333)Ggc>Tgc	p.G2111C		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2111					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTCTTGTGGCCCCTTCTGACA	0.423000										TSP Lung(27;0.18)			24	82					5.45024e-15	7.67657e-15	1	1	0
AHCTF1	25909	broad.mit.edu	37	1	247071049	247071049	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:247071049G>C	ENST00000366508.1	-	5	809	c.673C>G	c.(673-675)Cta>Gta	p.L225V	AHCTF1_ENST00000326225.3_Missense_Mutation_p.L199V|AHCTF1_ENST00000391829.2_Missense_Mutation_p.L190V			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	190	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			ATACCAGTTAGAACTTCAAGA	0.368000													3	52					0	0	1	0	0
PLD5	200150	broad.mit.edu	37	1	242287805	242287805	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:242287805G>A	ENST00000536534.2	-	6	1139	c.898C>T	c.(898-900)Cag>Tag	p.Q300*	PLD5_ENST00000442594.2_Nonsense_Mutation_p.Q208*|PLD5_ENST00000427495.1_Nonsense_Mutation_p.Q238*			Q8N7P1	PLD5_HUMAN	phospholipase D family, member 5							integral to membrane	catalytic activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(22)|ovary(6)|skin(3)|urinary_tract(1)	55	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			TCATTCAACTGAAGTTGCAAT	0.378000													6	49					0	0	1	0	0
DEF8	54849	broad.mit.edu	37	16	90025431	90025431	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr16:90025431G>A	ENST00000563594.1	+	6	1379	c.382G>A	c.(382-384)Gag>Aag	p.E128K	DEF8_ENST00000563848.1_3'UTR|DEF8_ENST00000567874.1_Missense_Mutation_p.E68K|DEF8_ENST00000268676.7_Missense_Mutation_p.E189K|DEF8_ENST00000418391.2_Missense_Mutation_p.E128K|DEF8_ENST00000570182.1_Missense_Mutation_p.E118K|DEF8_ENST00000563795.1_Missense_Mutation_p.E128K|DEF8_ENST00000569453.1_Missense_Mutation_p.E128K	NM_001242818.1|NM_001242819.1	NP_001229747.1|NP_001229748.1	Q6ZN54	DEFI8_HUMAN	differentially expressed in FDCP 8 homolog (mouse)	189					intracellular signal transduction		zinc ion binding			central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	12		all_cancers(9;7.59e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.0019)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0274)		GGACCCCAATGAGGATGAGCC	0.537000													8	95					0	0	1	0	0
ITGB4	3691	broad.mit.edu	37	17	73727424	73727424	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:73727424C>T	ENST00000200181.3	+	10	1377	c.1190C>T	c.(1189-1191)tCc>tTc	p.S397F	ITGB4_ENST00000450894.3_Missense_Mutation_p.S397F|ITGB4_ENST00000579662.1_Missense_Mutation_p.S397F|ITGB4_ENST00000449880.2_Missense_Mutation_p.S397F|ITGB4_ENST00000584558.1_3'UTR|ITGB4_ENST00000339591.3_Missense_Mutation_p.S397F	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	397					cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			AGGACTGGGTCCTTTCACATC	0.632000													10	42					0	0	1	0	0
ABCC2	1244	broad.mit.edu	37	10	101591826	101591826	+	Silent	SNP	C	C	A	rs72558199	byFrequency	TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr10:101591826C>A	ENST00000370449.4	+	23	3309	c.3196C>A	c.(3196-3198)Cga>Aga	p.R1066R		NM_000392.3	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	1066	ABC transmembrane type-1 2.					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CAATATCCTTCGAGCACCTAT	0.428000													10	59					0.010729	0.0116926	1	1	0
JADE2	23338	broad.mit.edu	37	5	133902070	133902070	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:133902070G>A	ENST00000395003.1	+	9	1413	c.1234G>A	c.(1234-1236)Gag>Aag	p.E412K	PHF15_ENST00000282605.4_Missense_Mutation_p.E412K|PHF15_ENST00000402835.1_Missense_Mutation_p.E412K|PHF15_ENST00000361895.2_Missense_Mutation_p.E412K	NM_015288.4	NP_056103.4	Q9NQC1	JADE2_HUMAN		412					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGAGCCGGCTGAGGTGGCTGA	0.622000													6	37					0	0	1	0	0
SLC8B1	80024	broad.mit.edu	37	12	113745598	113745598	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:113745598C>A	ENST00000552014.1	-	14	1824	c.1309G>T	c.(1309-1311)Gcc>Tcc	p.A437S	SLC8B1_ENST00000202831.3_Missense_Mutation_p.A437S|SLC8B1_ENST00000546737.1_Missense_Mutation_p.A381S|SLC8B1_ENST00000550047.1_5'UTR					solute carrier family 8 (sodium/lithium/calcium exchanger), member B1	437																	ACCTCTGTGGCGGCCGCGTTG	0.622000													5	19					1.23904e-05	1.53602e-05	1	1	0
UGGT1	56886	broad.mit.edu	37	2	128932429	128932429	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:128932429A>G	ENST00000375990.3	+	31	3867	c.3464A>G	c.(3463-3465)tAc>tGc	p.Y1155C	UGGT1_ENST00000259253.6_Missense_Mutation_p.Y1179C			Q9NYU2	UGGG1_HUMAN	UDP-glucose glycoprotein glucosyltransferase 1	1179					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			NS(1)|breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(14)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						TATAGAATTTACAGGTAGGAG	0.423000													13	51					0	0	1	0	0
RBM12B	389677	broad.mit.edu	37	8	94747019	94747019	+	Silent	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr8:94747019G>A	ENST00000399300.2	-	3	1833	c.1620C>T	c.(1618-1620)ttC>ttT	p.F540F	RBM12B_ENST00000520961.1_Intron|RBM12B_ENST00000517700.1_Silent_p.F540F	NM_203390.2	NP_976324.2	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	540							nucleotide binding|RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	30	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			GGGGATGCTTGAAGTTATCCA	0.493000													4	65					0	0	1	0	0
C22orf42	150297	broad.mit.edu	37	22	32555103	32555103	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr22:32555103C>T	ENST00000382097.3	-	1	172	c.100G>A	c.(100-102)Gag>Aag	p.E34K		NM_001010859.1	NP_001010859.1	Q6IC83	CV042_HUMAN	chromosome 22 open reading frame 42	34										NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(2)	24						GCCACAGTCTCAGGAATCTCA	0.577000													5	68					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48699656	48699656	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:48699656C>G	ENST00000544264.1	-	1	692	c.412G>C	c.(412-414)Gag>Cag	p.E138Q	CELSR3_ENST00000164024.4_Missense_Mutation_p.E138Q			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	138					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GAGGAGACCTCTGGGCGCCAG	0.637000													8	78					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	22061131	22061131	+	Silent	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:22061131C>A	ENST00000261200.4	-	9	1334	c.1335G>T	c.(1333-1335)gtG>gtT	p.V445V	ABCC9_ENST00000345162.2_Silent_p.V445V|ABCC9_ENST00000261201.4_Silent_p.V445V	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	445	ABC transmembrane type-1 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AGAGCAGAATCACGCCCATTA	0.408000													9	34					0.00621372	0.00686665	1	1	0
RYR1	6261	broad.mit.edu	37	19	38993575	38993575	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:38993575C>T	ENST00000355481.4	+	49	8022	c.7891C>T	c.(7891-7893)Ccc>Tcc	p.P2631S	RYR1_ENST00000360985.3_Missense_Mutation_p.P2631S|RYR1_ENST00000359596.3_Missense_Mutation_p.P2631S	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	2631	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GTTCGACGTGCCCATCCTCAA	0.602000													4	30					0	0	1	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735372	55735372	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:55735372C>A	ENST00000312345.2	-	1	618	c.568G>T	c.(568-570)Gtc>Ttc	p.V190F		NM_001005491.1	NP_001005491.1	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG, member 1	190					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(24)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	40	Esophageal squamous(21;0.0137)					ACTACATGGACTGTTATCTCA	0.388000													14	37					7.93312e-07	1.03212e-06	1	1	0
ORC3	23595	broad.mit.edu	37	6	88315679	88315679	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr6:88315679G>T	ENST00000392844.3	+	5	415	c.367G>T	c.(367-369)Gag>Tag	p.E123*	ORC3_ENST00000257789.4_Nonsense_Mutation_p.E123*|ORC3_ENST00000546266.1_5'UTR|ORC3_ENST00000417380.2_Nonsense_Mutation_p.E70*	NM_012381.3|NM_181837.2	NP_036513.2|NP_862820.1	Q9UBD5	ORC3_HUMAN	origin recognition complex, subunit 3	123					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	28						AAGTCTAACAGAGGCCCTTCA	0.313000													13	94					4.7546e-09	6.47982e-09	1	1	0
MYO18B	84700	broad.mit.edu	37	22	26294300	26294300	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr22:26294300C>T	ENST00000335473.7	+	29	4945	c.4695C>T	c.(4693-4695)gaC>gaT	p.D1565D	CTA-125H2.2_ENST00000607895.1_RNA|MYO18B_ENST00000536101.1_Silent_p.D1565D|CTA-125H2.2_ENST00000453457.3_RNA|MYO18B_ENST00000407587.2_Silent_p.D1566D|CTA-125H2.2_ENST00000609570.1_RNA|CTA-125H2.2_ENST00000597284.1_RNA|CTA-125H2.2_ENST00000600211.1_RNA|CTA-125H2.2_ENST00000608257.1_RNA|CTA-125H2.2_ENST00000609823.1_RNA|CTA-125H2.2_ENST00000608115.1_RNA|CTA-125H2.2_ENST00000608507.1_RNA|CTA-125H2.2_ENST00000594542.1_RNA|CTA-125H2.2_ENST00000609157.1_RNA|CTA-125H2.2_ENST00000594856.1_RNA|CTA-125H2.2_ENST00000600269.1_RNA|CTA-125H2.2_ENST00000599080.1_RNA|CTA-125H2.2_ENST00000594585.1_RNA|CTA-125H2.2_ENST00000609889.1_RNA|CTA-125H2.2_ENST00000599792.1_RNA|CTA-125H2.2_ENST00000595102.1_RNA|CTA-125H2.2_ENST00000609275.1_RNA|CTA-125H2.2_ENST00000597548.1_RNA|CTA-125H2.2_ENST00000600903.1_RNA	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1565	Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GTGCTTATGACGGGGCCAAGA	0.473000													8	32					0	0	1	0	0
C11orf70	85016	broad.mit.edu	37	11	101937236	101937236	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:101937236G>A	ENST00000434758.2	+	4	317	c.289G>A	c.(289-291)Gaa>Aaa	p.E97K	C11orf70_ENST00000534360.1_Intron|C11orf70_ENST00000526781.1_Missense_Mutation_p.E97K	NM_032930.2	NP_116319.2	Q9BRQ4	CK070_HUMAN	chromosome 11 open reading frame 70	97										breast(1)|kidney(1)|lung(5)|ovary(1)|prostate(2)|skin(2)	12	all_epithelial(12;0.0137)	Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.0137)	Lung(13;0.245)	BRCA - Breast invasive adenocarcinoma(274;0.0335)		GAAAAAAATTGAAGCTATAAA	0.274000													14	131					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158609748	158609748	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:158609748G>T	ENST00000368147.4	-	34	4967	c.4787C>A	c.(4786-4788)aCa>aAa	p.T1596K		NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)						actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TTTGTCATTTGTTCTCTCAAG	0.493000													8	85					0.00448238	0.00501486	1	1	0
RTP1	132112	broad.mit.edu	37	3	186917786	186917786	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:186917786C>T	ENST00000312295.4	+	2	750	c.720C>T	c.(718-720)ccC>ccT	p.P240P	RP11-208N14.4_ENST00000356133.3_RNA	NM_153708.2	NP_714919.2	P59025	RTP1_HUMAN	receptor (chemosensory) transporter protein 1	240					protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			breast(2)|endometrium(4)|large_intestine(5)|lung(6)|ovary(3)|skin(2)	22	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		GCTCTATCCCCTGGTGCTTGT	0.607000													7	68					0	0	1	0	0
CCDC8	83987	broad.mit.edu	37	19	46914756	46914756	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:46914756C>A	ENST00000307522.3	-	1	2085	c.1312G>T	c.(1312-1314)Gca>Tca	p.A438S		NM_032040.4	NP_114429.2	Q9H0W5	CCDC8_HUMAN	coiled-coil domain containing 8	438						plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;4.66e-05)|all cancers(93;0.000582)|Epithelial(262;0.00428)|GBM - Glioblastoma multiforme(486;0.0421)		GCAGCCTCTGCCCTCTGGCCA	0.612000													4	34					0.00909568	0.00992971	1	1	0
PPHLN1	51535	broad.mit.edu	37	12	42768741	42768741	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:42768741G>A	ENST00000432191.2	+	4	283	c.211G>A	c.(211-213)Gac>Aac	p.D71N	PPHLN1_ENST00000552761.1_Missense_Mutation_p.D78N|PPHLN1_ENST00000317560.9_Missense_Mutation_p.D78N|PPHLN1_ENST00000256678.8_Missense_Mutation_p.D25N|PPHLN1_ENST00000395580.3_Missense_Mutation_p.D133N|PPHLN1_ENST00000395568.2_Missense_Mutation_p.D126N|PPHLN1_ENST00000449194.2_Missense_Mutation_p.D126N|PPHLN1_ENST00000549190.1_Missense_Mutation_p.D144N|PPHLN1_ENST00000337898.6_Missense_Mutation_p.D71N|PPHLN1_ENST00000358314.7_Missense_Mutation_p.D126N	NM_001143787.1	NP_001137259.1	Q8NEY8	PPHLN_HUMAN	periphilin 1	126					keratinization	cytoplasm|nucleus				breast(5)|kidney(1)|large_intestine(4)|lung(2)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	16	all_cancers(12;0.00049)|Breast(8;0.165)	Lung NSC(34;0.123)		GBM - Glioblastoma multiforme(48;0.0875)		TTATAAAAGGGACAATACTTT	0.408000													23	52					0	0	1	0	0
USH1C	10083	broad.mit.edu	37	11	17544788	17544788	+	Silent	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:17544788G>A	ENST00000005226.7	-	11	845	c.846C>T	c.(844-846)cgC>cgT	p.R282R	USH1C_ENST00000318024.4_Silent_p.R282R|USH1C_ENST00000527720.1_Silent_p.R251R|USH1C_ENST00000527020.1_Intron	NM_153676.3	NP_710142.1	Q9Y6N9	USH1C_HUMAN	Usher syndrome 1C (autosomal recessive, severe)	282	PDZ 2.				equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	48						TGGTCAGGCTGCGGCTACTCT	0.587000													6	61					0	0	1	0	0
PSTPIP1	9051	broad.mit.edu	37	15	77328221	77328221	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr15:77328221G>A	ENST00000558012.1	+	14	1553	c.1064G>A	c.(1063-1065)gGa>gAa	p.G355E	PSTPIP1_ENST00000557995.1_3'UTR|PSTPIP1_ENST00000379595.3_Missense_Mutation_p.G352E|PSTPIP1_ENST00000267939.5_Missense_Mutation_p.G335E|PSTPIP1_ENST00000559295.1_Missense_Mutation_p.G336E	NM_003978.3	NP_003969.2	O43586	PPIP1_HUMAN	proline-serine-threonine phosphatase interacting protein 1	355					cell adhesion|signal transduction	cleavage furrow|lamellipodium|perinuclear region of cytoplasm	catalytic activity			breast(1)|endometrium(3)|lung(2)|ovary(2)|upper_aerodigestive_tract(1)	9						GAGATACAGGGAAACCCGGCC	0.612000													3	8					0	0	1	0	0
ARHGAP9	64333	broad.mit.edu	37	12	57870388	57870388	+	Missense_Mutation	SNP	C	C	T	rs139460885		TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:57870388C>T	ENST00000393797.2	-	10	1415	c.1223G>A	c.(1222-1224)gGg>gAg	p.G408E	ARHGAP9_ENST00000550454.1_5'UTR|ARHGAP9_ENST00000424809.2_Missense_Mutation_p.G337E|ARHGAP9_ENST00000393791.3_Missense_Mutation_p.G337E|ARHGAP9_ENST00000550288.1_Missense_Mutation_p.G416E|ARHGAP9_ENST00000356411.2_Missense_Mutation_p.G337E|ARHGAP9_ENST00000430041.2_Missense_Mutation_p.G153E			Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9	337	PH.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)	30			GBM - Glioblastoma multiforme(3;3.37e-34)			CTTGCGCCCCCCTTGGGCAAT	0.577000													27	59					0	0	1	0	0
ACTB	60	broad.mit.edu	37	7	5567439	5567439	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:5567439C>G	ENST00000331789.5	-	6	1259	c.1068G>C	c.(1066-1068)tgG>tgC	p.W356C	ACTB_ENST00000464611.1_5'UTR	NM_001101.3	NP_001092.1	P60709	ACTB_HUMAN	actin, beta	356					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(2)|prostate(2)	8		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		GCTTGCTGATCCACATCTGCT	0.567000													8	129					0	0	1	0	0
DGKB	1607	broad.mit.edu	37	7	14758228	14758228	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:14758228C>T	ENST00000403951.2	-	6	824	c.405G>A	c.(403-405)ctG>ctA	p.L135L	DGKB_ENST00000444700.2_Silent_p.L128L|DGKB_ENST00000258767.5_Silent_p.L135L|DGKB_ENST00000402815.1_Silent_p.L135L|DGKB_ENST00000406247.3_Silent_p.L135L|DGKB_ENST00000407950.1_Silent_p.L128L|DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000399322.3_Silent_p.L135L			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	135					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	CAATGTCCTTCAGATGGATTA	0.428000													3	20					0	0	1	0	0
MTFMT	123263	broad.mit.edu	37	15	65297264	65297264	+	Missense_Mutation	SNP	T	T	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr15:65297264T>A	ENST00000220058.4	-	8	916	c.903A>T	c.(901-903)ttA>ttT	p.L301F		NM_139242.3	NP_640335.2	Q96DP5	FMT_HUMAN	mitochondrial methionyl-tRNA formyltransferase	301						mitochondrion	methionyl-tRNA formyltransferase activity|methyltransferase activity			endometrium(1)|large_intestine(3)|lung(3)|ovary(3)	10					Tetrahydrofolic acid(DB00116)	CCTGTCCCGTTAATTTTGGAT	0.308000													6	27					0	0	1	0	0
PSMA5	5686	broad.mit.edu	37	1	109964526	109964526	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:109964526C>T	ENST00000271308.4	-	2	72	c.52G>A	c.(52-54)Gaa>Aaa	p.E18K	PSMA5_ENST00000490870.1_5'UTR|PSMA5_ENST00000538610.1_Intron	NM_002790.3	NP_002781.2	P28066	PSA5_HUMAN	proteasome (prosome, macropain) subunit, alpha type, 5	18					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	protein binding|threonine-type endopeptidase activity			kidney(1)|large_intestine(2)|lung(2)	5		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.045)|Colorectal(144;0.116)|Epithelial(280;0.187)|all cancers(265;0.196)|LUSC - Lung squamous cell carcinoma(189;0.235)		AATCTTCCTTCGGGAGAAAAA	0.343000													5	46					0	0	1	0	0
GABPB2	126626	broad.mit.edu	37	1	151070408	151070408	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:151070408C>T	ENST00000368918.3	+	5	883	c.552C>T	c.(550-552)ttC>ttT	p.F184F	GABPB2_ENST00000368917.1_Silent_p.F184F|GABPB2_ENST00000467551.1_3'UTR|GABPB2_ENST00000368916.1_Silent_p.F184F	NM_144618.2	NP_653219.1	Q8TAK5	GABP2_HUMAN	GA binding protein transcription factor, beta subunit 2	184					positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	protein heterodimerization activity|transcription regulatory region DNA binding			breast(1)|endometrium(2)|large_intestine(3)|liver(2)|lung(7)	15				all cancers(107;7.17e-05)|GBM - Glioblastoma multiforme(94;0.000662)		CTGCTCCATTCATCTTCACGT	0.428000													7	73					0	0	1	0	0
SEC14L1	6397	broad.mit.edu	37	17	75187290	75187290	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:75187290G>T	ENST00000413679.2	+	5	544	c.241G>T	c.(241-243)Gtc>Ttc	p.V81F	SEC14L1_ENST00000591437.1_Missense_Mutation_p.V47F|SEC14L1_ENST00000392476.2_Missense_Mutation_p.V81F|SEC14L1_ENST00000443798.4_Missense_Mutation_p.V81F|SEC14L1_ENST00000430767.4_Missense_Mutation_p.V81F|SEC14L1_ENST00000436233.4_Missense_Mutation_p.V81F|SEC14L1_ENST00000431431.2_Missense_Mutation_p.V47F|SEC14L1_ENST00000585618.1_Missense_Mutation_p.V81F	NM_001143998.1|NM_001143999.1|NM_003003.3	NP_001137470|NP_001137471|NP_002994	Q92503	S14L1_HUMAN	SEC14-like 1 (S. cerevisiae)	81	PRELI/MSF1.				transport	Golgi apparatus|integral to membrane	binding			NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(2)	31						TGTTTATTTTGTCCAGAAAAA	0.338000													16	134					6.72482e-11	9.34662e-11	1	1	0
HELZ	9931	broad.mit.edu	37	17	65214778	65214778	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:65214778C>A	ENST00000358691.5	-	4	309	c.143G>T	c.(142-144)tGt>tTt	p.C48F	HELZ_ENST00000580662.1_5'UTR|HELZ_ENST00000580168.1_Missense_Mutation_p.C48F	NM_014877.3	NP_055692			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TTCCAATGGACAAGGCCCTGT	0.458000													20	72					8.10497e-08	1.09046e-07	1	1	0
PEX1	5189	broad.mit.edu	37	7	92120771	92120771	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:92120771C>G	ENST00000248633.4	-	21	3348	c.3253G>C	c.(3253-3255)Gtc>Ctc	p.V1085L	AC007566.10_ENST00000427458.1_RNA|PEX1_ENST00000428214.1_Missense_Mutation_p.V1028L|AC007566.10_ENST00000441539.1_RNA|PEX1_ENST00000438045.1_Missense_Mutation_p.V763L	NM_000466.2	NP_000457.1	O43933	PEX1_HUMAN	peroxisomal biogenesis factor 1	1085					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TTAAGAAAGACCATTGAAGAC	0.413000													6	58					0	0	1	0	0
ARRB2	409	broad.mit.edu	37	17	4621908	4621908	+	Splice_Site	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:4621908G>A	ENST00000269260.2	+	10	941	c.708G>A	c.(706-708)gtG>gtA	p.V236V	ARRB2_ENST00000572457.1_Splice_Site_p.V44V|ARRB2_ENST00000412477.3_Splice_Site_p.V257V|ARRB2_ENST00000574954.1_Splice_Site_p.V44V|ARRB2_ENST00000381488.6_Splice_Site_p.V221V|ARRB2_ENST00000571206.1_Splice_Site_p.V44V|ARRB2_ENST00000346341.2_Splice_Site_p.V221V|ARRB2_ENST00000575877.1_Splice_Site_p.V236V	NM_001257328.1|NM_001257330.1|NM_004313.3	NP_001244257.1|NP_001244259.1|NP_004304.1	P32121	ARRB2_HUMAN	arrestin, beta 2	236					cell chemotaxis|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|G-protein coupled receptor internalization|negative regulation of natural killer cell mediated cytotoxicity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|transcription from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway	coated pit|cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	angiotensin receptor binding|ubiquitin protein ligase binding	p.V236V(1)		large_intestine(1)|liver(2)|lung(3)|prostate(1)	7						ACCCCACAGTGAGACAGTACG	0.612000													8	80					0	0	1	0	0
TXNDC2	84203	broad.mit.edu	37	18	9886691	9886691	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr18:9886691C>A	ENST00000357775.5	+	2	249	c.14C>A	c.(13-15)aCg>aAg	p.T5K	TXNDC2_ENST00000426718.3_3'UTR|TXNDC2_ENST00000536353.2_Missense_Mutation_p.T5K|TXNDC2_ENST00000306084.6_Missense_Mutation_p.T72K	NM_032243.5	NP_115619.4	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)						cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						GTCAGCCACACGTTCCACATG	0.567000													5	34					0.0215528	0.0229339	1	1	0
DMTF1	9988	broad.mit.edu	37	7	86817604	86817604	+	Silent	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:86817604G>A	ENST00000414194.2	+	13	2392	c.600G>A	c.(598-600)caG>caA	p.Q200Q	DMTF1_ENST00000331242.7_Silent_p.Q466Q|DMTF1_ENST00000432937.2_Silent_p.Q378Q|DMTF1_ENST00000413276.2_Intron|DMTF1_ENST00000394703.5_Silent_p.Q466Q			Q9Y222	DMTF1_HUMAN	cyclin D binding myb-like transcription factor 1	466	Interaction with CCND1, CCND2 and CCND3 (By similarity).|Interaction with CCND2 (By similarity).|Required for DNA-binding (By similarity).				cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)	16	Esophageal squamous(14;0.0058)					TTCCAGTCCAGATCACCCATG	0.418000													7	94					0	0	1	0	0
MAP4	4134	broad.mit.edu	37	3	47960221	47960221	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:47960221G>A	ENST00000426837.2	-	7	778	c.691C>T	c.(691-693)Cag>Tag	p.Q231*	MAP4_ENST00000395734.3_Nonsense_Mutation_p.Q214*|MAP4_ENST00000383737.4_Nonsense_Mutation_p.Q214*|MAP4_ENST00000360240.6_Nonsense_Mutation_p.Q214*			P27816	MAP4_HUMAN	microtubule-associated protein 4	214					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(2)	32				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		GCCGTTGGCTGAGGAGGTTCT	0.448000													4	40					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38689051	38689051	+	Silent	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:38689051C>G	ENST00000222345.6	+	19	5372	c.4863C>G	c.(4861-4863)ctC>ctG	p.L1621L		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	1621					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CCTCGGAGCTCTCGCTGGCTG	0.637000													17	144					0	0	1	0	0
CAPS2	84698	broad.mit.edu	37	12	75683421	75683421	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:75683421G>T	ENST00000393284.3	-	14	1337	c.736C>A	c.(736-738)Cac>Aac	p.H246N	CAPS2_ENST00000409004.1_5'UTR|CAPS2_ENST00000442339.2_Missense_Mutation_p.H68N|CAPS2_ENST00000409445.3_Missense_Mutation_p.H478N|CAPS2_ENST00000409799.1_Missense_Mutation_p.H396N|RP11-560G2.1_ENST00000549953.1_RNA			Q9BXY5	CAYP2_HUMAN	calcyphosine 2	478							calcium ion binding			endometrium(2)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	10						ACTTCTAAGTGAAACACTTTT	0.338000													6	64					0.0215528	0.0229339	1	1	0
INSRR	3645	broad.mit.edu	37	1	156821123	156821123	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:156821123G>C	ENST00000368195.3	-	5	1584	c.1188C>G	c.(1186-1188)ttC>ttG	p.F396L	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	396					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TGAGGTTCTTGAAAAAGCCCA	0.542000													15	136					0	0	1	0	0
NAV2	89797	broad.mit.edu	37	11	20065659	20065659	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:20065659G>C	ENST00000396085.1	+	13	3401	c.3040G>C	c.(3040-3042)Gat>Cat	p.D1014H	NAV2_ENST00000540292.1_Missense_Mutation_p.D968H|NAV2_ENST00000311043.8_Missense_Mutation_p.D100H|NAV2_ENST00000527559.2_Missense_Mutation_p.D966H|NAV2_ENST00000533917.1_Missense_Mutation_p.D100H|NAV2_ENST00000349880.4_Missense_Mutation_p.D1014H|NAV2_ENST00000396087.3_Missense_Mutation_p.D1037H|NAV2_ENST00000360655.4_Missense_Mutation_p.D950H|NAV2-AS2_ENST00000533767.1_RNA	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	1037						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						GAATCCTTCTGATGTGTCTGA	0.542000													6	67					0	0	1	0	0
ARPC1A	10552	broad.mit.edu	37	7	98951688	98951688	+	Silent	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:98951688G>T	ENST00000432884.2	+	8	977	c.516G>T	c.(514-516)ctG>ctT	p.L172L	ARPC1A_ENST00000262942.5_Silent_p.L219L|ARPC1A_ENST00000471960.1_3'UTR			Q92747	ARC1A_HUMAN	actin related protein 2/3 complex, subunit 1A, 41kDa	219					actin cytoskeleton organization|regulation of actin filament polymerization	actin cytoskeleton|cytoplasm	actin binding			endometrium(3)|large_intestine(5)|liver(2)|lung(7)|ovary(1)|prostate(1)	19	all_cancers(62;4.46e-09)|all_epithelial(64;3.44e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0258)		STAD - Stomach adenocarcinoma(171;0.215)			GGAGCCGCCTGGCCTGGGTCA	0.577000													14	36					4.93089e-13	6.89887e-13	1	1	0
WNT9B	7484	broad.mit.edu	37	17	44953783	44953783	+	Missense_Mutation	SNP	G	G	T	rs149931425	by1000genomes	TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:44953783G>T	ENST00000393461.2	+	4	826	c.773G>T	c.(772-774)cGc>cTc	p.R258L	WNT9B_ENST00000290015.2_Missense_Mutation_p.R258L			O14905	WNT9B_HUMAN	wingless-type MMTV integration site family, member 9B	258					anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|collecting duct development|cornea development in camera-type eye|endoderm development|establishment of planar polarity involved in nephron morphogenesis|kidney rudiment formation|male genitalia development|mesonephric duct formation|metanephric tubule development|neuron differentiation|palate development|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|uterus morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway|Wnt receptor signaling pathway, planar cell polarity pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding			large_intestine(2)|lung(8)	10			BRCA - Breast invasive adenocarcinoma(9;0.0257)			GCCTTGGGCCGCCTAGAGCTG	0.642000													14	61					3.45872e-05	4.27094e-05	1	1	0
BCL11A	53335	broad.mit.edu	37	2	60687791	60687791	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:60687791C>G	ENST00000335712.6	-	4	2483	c.2256G>C	c.(2254-2256)aaG>aaC	p.K752N	BCL11A_ENST00000538214.1_Missense_Mutation_p.K718N|BCL11A_ENST00000356842.4_Intron|BCL11A_ENST00000358510.4_Missense_Mutation_p.K718N|BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000359629.5_Intron|BCL11A_ENST00000537768.1_Intron	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	752					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding	p.K752K(1)		NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			TGCTACAGTTCTTGAAGACTT	0.562000			T	IGH@	B-CLL								5	95					0	0	1	0	0
TTC40	54777	broad.mit.edu	37	10	134743185	134743185	+	Silent	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr10:134743185C>G	ENST00000368585.3	-	9	1328	c.990G>C	c.(988-990)ctG>ctC	p.L330L	TTC40_ENST00000368586.5_Intron|TTC40_ENST00000368582.2_Intron			Q8IYW2	CJ092_HUMAN	tetratricopeptide repeat domain 40	0										breast(1)|endometrium(5)|lung(19)|urinary_tract(3)	28						CATCCCCAGGCAGCAGTGTCA	0.552000													12	66					0	0	1	0	0
C11orf48	79081	broad.mit.edu	37	11	62435193	62435193	+	Silent	SNP	T	T	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:62435193T>G	ENST00000431002.2	-	2	2151	c.418A>C	c.(418-420)Aga>Cga	p.R140R	C11orf48_ENST00000354588.3_Silent_p.R114R|C11orf48_ENST00000532208.1_Silent_p.R114R|METTL12_ENST00000532971.1_3'UTR			Q9BQE6	CK048_HUMAN	chromosome 11 open reading frame 48	140										endometrium(1)|lung(5)|urinary_tract(1)	7						AAAGGACTTCTAGGGTCCTGT	0.478000													26	135					0	0	1	0	0
UGT3A1	133688	broad.mit.edu	37	5	35965696	35965696	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:35965696C>T	ENST00000274278.3	-	4	992	c.635G>A	c.(634-636)aGg>aAg	p.R212K	UGT3A1_ENST00000333811.4_Missense_Mutation_p.R158K|UGT3A1_ENST00000513233.1_Intron|UGT3A1_ENST00000503189.1_Missense_Mutation_p.R212K|UGT3A1_ENST00000507113.1_Missense_Mutation_p.R178K	NM_152404.3	NP_689617.3	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	212						integral to membrane	glucuronosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|skin(4)	46	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CCATTGGCTCCTGGAGAAACT	0.463000													3	50					0	0	1	0	0
TXNDC15	79770	broad.mit.edu	37	5	134232072	134232072	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:134232072C>T	ENST00000358387.4	+	4	1469	c.844C>T	c.(844-846)Cga>Tga	p.R282*	TXNDC15_ENST00000546290.1_Nonsense_Mutation_p.R259*	NM_024715.3	NP_078991.3	Q96J42	TXD15_HUMAN	thioredoxin domain containing 15	282	Thioredoxin.				cell redox homeostasis	integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(1)	17			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TCATACAGATCGAACACTGGA	0.388000													8	91					0	0	1	0	0
SYT2	127833	broad.mit.edu	37	1	202568381	202568381	+	Missense_Mutation	SNP	A	A	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:202568381A>T	ENST00000367267.1	-	8	1210	c.1018T>A	c.(1018-1020)Tcc>Acc	p.S340T	SYT2_ENST00000367268.4_Missense_Mutation_p.S340T	NM_001136504.1	NP_001129976.1	Q8N9I0	SYT2_HUMAN	synaptotagmin II	340	C2 2.|Phospholipid binding (By similarity).				neurotransmitter secretion	cell junction|chromaffin granule membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	protein binding|transporter activity			NS(1)|breast(4)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(9)|ovary(2)|skin(2)|urinary_tract(1)	29			BRCA - Breast invasive adenocarcinoma(75;0.169)		Botulinum Toxin Type B(DB00042)	AAGCTGAAGGACTCGTTGAAG	0.527000													6	79					0	0	1	0	0
MYO1G	64005	broad.mit.edu	37	7	45016595	45016595	+	Silent	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:45016595C>A	ENST00000258787.7	-	2	307	c.171G>T	c.(169-171)ctG>ctT	p.L57L		NM_033054.2	NP_149043.2	B0I1T2	MYO1G_HUMAN	myosin IG	57	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|skin(4)	28						CAGGCCCATACAGGGGCAGCT	0.622000													7	37					5.18039e-06	6.60369e-06	1	1	0
CDH26	60437	broad.mit.edu	37	20	58559852	58559852	+	Missense_Mutation	SNP	G	G	C	rs150010707	byFrequency	TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr20:58559852G>C	ENST00000348616.4	+	6	1000	c.700G>C	c.(700-702)Gat>Cat	p.D234H	CDH26_ENST00000244047.5_Missense_Mutation_p.D234H	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	234	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			TGGCTGCTTAGATTATGAGGT	0.408000													22	87					0	0	1	0	0
AP3B2	8120	broad.mit.edu	37	15	83334319	83334319	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr15:83334319G>C	ENST00000261722.3	-	16	2068	c.1861C>G	c.(1861-1863)Cac>Gac	p.H621D	AP3B2_ENST00000535359.1_Missense_Mutation_p.H621D|AP3B2_ENST00000535348.1_Missense_Mutation_p.H589D|RP11-752G15.3_ENST00000560650.1_RNA	NM_004644.3	NP_004635.2	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2 subunit	621					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			breast(4)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(2)	41			BRCA - Breast invasive adenocarcinoma(143;0.229)			AGCTGGAAGTGGTCCCGGTCT	0.602000													5	51					0	0	1	0	0
ANO9	338440	broad.mit.edu	37	11	418916	418916	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:418916C>G	ENST00000332826.6	-	21	2092	c.2008G>C	c.(2008-2010)Gag>Cag	p.E670Q		NM_001012302.2	NP_001012302	A1A5B4	ANO9_HUMAN	anoctamin 9	670						chloride channel complex	chloride channel activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|lung(5)|ovary(1)|prostate(4)|skin(4)	21						TCTGAGCCCTCAATCCCATCA	0.587000													16	146					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14543047	14543047	+	Silent	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr18:14543047G>A	ENST00000358970.5	-	1	98	c.99C>T	c.(97-99)ccC>ccT	p.P33P	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	33										NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						CCTTGCAGCAGGGGAAGCGGT	0.552000													14	141					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40677743	40677743	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:40677743G>A	ENST00000298910.7	+	19	2366	c.2308G>A	c.(2308-2310)Gat>Aat	p.D770N	LRRK2_ENST00000343742.2_Missense_Mutation_p.D770N	NM_198578.3	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	770					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TCGTGAACAAGATGTACGAAA	0.403000													18	47					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113558279	113558279	+	Missense_Mutation	SNP	A	A	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:113558279A>C	ENST00000284601.3	-	1	841	c.773T>G	c.(772-774)gTa>gGa	p.V258G		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	258					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						CCTTGATTTTACCTTTAAGCA	0.299000													17	104					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	70040457	70040457	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr6:70040457T>C	ENST00000370598.1	+	23	3916	c.3095T>C	c.(3094-3096)gTt>gCt	p.V1032A	BAI3_ENST00000238918.8_Missense_Mutation_p.V238A	NM_001704.2	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1032					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				GCAGCCGCTGTTGTCCTGGTA	0.358000													5	31					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120470957	120470957	+	Silent	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr9:120470957C>G	ENST00000355622.6	+	2	311	c.210C>G	c.(208-210)ggC>ggG	p.G70G	TLR4_ENST00000472304.1_Intron|TLR4_ENST00000394487.4_Silent_p.G30G	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	70					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						GGCATTTAGGCAGCTATAGCT	0.453000													6	92					0	0	1	0	0
KRTAP4-6	81871	broad.mit.edu	37	17	39296627	39296627	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:39296627G>T	ENST00000345847.4	-	1	112	c.113C>A	c.(112-114)cCc>cAc	p.P38H		NM_030976.1	NP_112238.1	Q9BYQ5	KRA46_HUMAN	keratin associated protein 4-6	38	29 X 5 AA repeats of C-C-[IRQVEL]-[SPTR]- [STVQRCP].					keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(1)|prostate(1)|urinary_tract(1)	9						ACAGCAGCTGGGGCGGCAGCA	0.667000													8	38					0.000157383	0.000187375	1	1	0
IGSF10	285313	broad.mit.edu	37	3	151171209	151171209	+	Silent	SNP	A	A	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:151171209A>G	ENST00000282466.3	-	3	677	c.678T>C	c.(676-678)caT>caC	p.H226H		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	226	LRRCT.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ACCACTTTAAATGGCAATCAC	0.433000													24	71					0	0	1	0	0
ANAPC16	119504	broad.mit.edu	37	10	73992771	73992771	+	Missense_Mutation	SNP	C	C	G	rs138956935		TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr10:73992771C>G	ENST00000299381.4	+	4	348	c.230C>G	c.(229-231)gCt>gGt	p.A77G	ANAPC16_ENST00000470481.2_3'UTR	NM_001242546.1|NM_001242547.1|NM_001242548.1|NM_173473.3	NP_001229475.1|NP_001229476.1|NP_001229477.1|NP_775744.1	Q96DE5	APC16_HUMAN	anaphase promoting complex subunit 16	77					cell division|mitosis|protein ubiquitination	anaphase-promoting complex|cytoplasm				large_intestine(1)|ovary(1)	2						CAGCAAGTTGCTCGGATGGAA	0.483000													9	37					0	0	1	0	0
CNKSR2	22866	broad.mit.edu	37	X	21534627	21534627	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:21534627G>C	ENST00000425654.2	+	9	1315	c.835G>C	c.(835-837)Gtg>Ctg	p.V279L	CNKSR2_ENST00000543067.1_Intron|CNKSR2_ENST00000279451.4_Missense_Mutation_p.V279L|CNKSR2_ENST00000379510.3_Missense_Mutation_p.V279L	NM_001168647.1	NP_001162118.1	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras 2	279	PDZ.				regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						GAAAAATTTGGTGAATGCACT	0.398000													8	83					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61513002	61513002	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr20:61513002C>A	ENST00000266070.4	-	16	4631	c.4306G>T	c.(4306-4308)Gaa>Taa	p.E1436*	DIDO1_ENST00000395343.1_Nonsense_Mutation_p.E1436*	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1436					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					ACTTTCGCTTCTTCTAAGATG	0.637000													11	110					3.86212e-05	4.73203e-05	1	1	0
NHLRC3	387921	broad.mit.edu	37	13	39613332	39613332	+	Silent	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr13:39613332G>T	ENST00000379600.3	+	2	466	c.144G>T	c.(142-144)ctG>ctT	p.L48L	NHLRC3_ENST00000470258.1_5'UTR|NHLRC3_ENST00000379599.2_Silent_p.L48L	NM_001012754.3	NP_001012772.1	Q5JS37	NHLC3_HUMAN	NHL repeat containing 3	48						extracellular region				breast(1)|kidney(1)|large_intestine(3)|lung(4)|skin(2)	11		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;2.37e-08)|Epithelial(112;3.14e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00101)|BRCA - Breast invasive adenocarcinoma(63;0.00335)|GBM - Glioblastoma multiforme(144;0.0128)		TTTACCGGCTGGATGTGGGTT	0.388000													5	80					0.0215528	0.0229339	1	1	0
NCK1	4690	broad.mit.edu	37	3	136664750	136664750	+	Silent	SNP	T	T	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:136664750T>C	ENST00000469404.1	+	2	451	c.360T>C	c.(358-360)aaT>aaC	p.N120N	NCK1_ENST00000288986.2_Silent_p.N184N|NCK1_ENST00000481752.1_Silent_p.N184N	NM_001190796.1	NP_001177725.1	P16333	NCK1_HUMAN	NCK adaptor protein 1	184	SH3 2.				axon guidance|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of translation|signal complex assembly|T cell activation|T cell receptor signaling pathway	cytosol|endoplasmic reticulum|nucleus	cytoskeletal adaptor activity|receptor binding|receptor signaling complex scaffold activity			cervix(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	13						CAGTCGTCAATAACCTAAATA	0.423000													18	106					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51175917	51175917	+	Missense_Mutation	SNP	T	T	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr16:51175917T>G	ENST00000251020.4	-	2	249	c.216A>C	c.(214-216)ttA>ttC	p.L72F	SALL1_ENST00000541611.1_Intron|SALL1_ENST00000566102.1_Intron|SALL1_ENST00000440970.1_5'UTR	NM_002968.2	NP_002959.2	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	72					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CATTTACGATTAAAACTAATT	0.453000													4	65					0	0	1	0	0
KCNMB1	3779	broad.mit.edu	37	5	169805863	169805863	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:169805863C>T	ENST00000274629.4	-	4	863	c.421G>A	c.(421-423)Ggg>Agg	p.G141R	KCNIP1_ENST00000377360.4_Intron|KCNIP1_ENST00000518527.1_Intron	NM_004137.3	NP_004128.1	Q16558	KCMB1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, beta member 1	141					platelet activation|synaptic transmission		calcium-activated potassium channel activity|potassium channel regulator activity			endometrium(1)|large_intestine(1)|lung(7)|ovary(2)	11	Renal(175;0.000159)|Lung NSC(126;0.0165)|all_lung(126;0.026)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.175)		GTTTCGTTCCCCCGAGGTGCG	0.622000													5	16					0	0	1	0	0
SPATA4	132851	broad.mit.edu	37	4	177116567	177116567	+	Silent	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr4:177116567G>T	ENST00000280191.2	-	1	255	c.147C>A	c.(145-147)tcC>tcA	p.S49S		NM_144644.2	NP_653245.2	Q8NEY3	SPAT4_HUMAN	spermatogenesis associated 4	49					apoptosis|spermatogenesis					NS(2)|cervix(1)|endometrium(2)|large_intestine(7)|lung(10)	22		Breast(14;0.0011)|Prostate(90;0.0129)|Melanoma(52;0.0133)|Renal(120;0.0376)|all_hematologic(60;0.124)		all cancers(43;2.9e-20)|Epithelial(43;1.99e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.58e-09)|GBM - Glioblastoma multiforme(59;0.000162)|STAD - Stomach adenocarcinoma(60;0.000543)|LUSC - Lung squamous cell carcinoma(193;0.096)		GAGACAAGCGGGAGCTCTTCG	0.582000													7	44					0.0477658	0.0503175	1	1	0
TRRAP	8295	broad.mit.edu	37	7	98535294	98535294	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:98535294G>A	ENST00000359863.4	+	30	4464	c.4255G>A	c.(4255-4257)Gaa>Aaa	p.E1419K	TRRAP_ENST00000446306.3_Missense_Mutation_p.E1418K|TRRAP_ENST00000355540.3_Missense_Mutation_p.E1419K	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	1419					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TGCTACCATAGAAGTCGATCA	0.398000													8	77					0	0	1	0	0
ACTB	60	broad.mit.edu	37	7	5568036	5568036	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:5568036C>G	ENST00000331789.5	-	4	869	c.678G>C	c.(676-678)gaG>gaC	p.E226D		NM_001101.3	NP_001092.1	P60709	ACTB_HUMAN	actin, beta	226					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(2)|prostate(2)	8		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		CCGTGGCCATCTCTTGCTCGA	0.617000													9	77					0	0	1	0	0
C10orf12	26148	broad.mit.edu	37	10	98744615	98744615	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr10:98744615G>C	ENST00000286067.2	+	1	3575	c.3468G>C	c.(3466-3468)aaG>aaC	p.K1156N		NM_015652.2	NP_056467.2	Q8N655	CJ012_HUMAN	chromosome 10 open reading frame 12	1156										NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(3)|prostate(2)|skin(2)|stomach(4)	45		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		CCGCTGGGAAGAGCTGCCCTC	0.498000													4	31					0	0	1	0	0
MARK2	2011	broad.mit.edu	37	11	63667482	63667482	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:63667482G>A	ENST00000402010.2	+	8	1247	c.668G>A	c.(667-669)gGc>gAc	p.G223D	MARK2_ENST00000509502.2_Missense_Mutation_p.G190D|MARK2_ENST00000502399.3_Missense_Mutation_p.G223D|MARK2_ENST00000413835.2_Missense_Mutation_p.G223D|MARK2_ENST00000408948.3_Missense_Mutation_p.G190D|MARK2_ENST00000315032.8_Missense_Mutation_p.G223D|MARK2_ENST00000361128.5_Missense_Mutation_p.G223D|MARK2_ENST00000377809.4_Missense_Mutation_p.G223D|MARK2_ENST00000508192.1_Missense_Mutation_p.G223D|MARK2_ENST00000425897.2_Missense_Mutation_p.G190D|MARK2_ENST00000350490.7_Missense_Mutation_p.G223D|MARK2_ENST00000513765.2_Missense_Mutation_p.G190D|MARK2_ENST00000377810.3_Missense_Mutation_p.G190D	NM_001039469.2	NP_001034558.2	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	223	Protein kinase.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33						CTCTTCCAGGGCAAAAAATAT	0.502000													4	157					0	0	1	0	0
ADAM22	53616	broad.mit.edu	37	7	87810908	87810908	+	Missense_Mutation	SNP	A	A	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:87810908A>T	ENST00000398204.4	+	27	2712	c.2389A>T	c.(2389-2391)Aac>Tac	p.N797Y	ADAM22_ENST00000398201.4_Missense_Mutation_p.N833Y|ADAM22_ENST00000265727.7_Missense_Mutation_p.N833Y|ADAM22_ENST00000398209.3_Missense_Mutation_p.N797Y|ADAM22_ENST00000315984.7_Missense_Mutation_p.N797Y	NM_016351.4|NM_021723.3	NP_057435.2|NP_068369.1	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22	833					cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			endometrium(7)|kidney(4)|large_intestine(7)|liver(2)|lung(20)|ovary(6)|prostate(4)|skin(3)	53	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			ACCTCGAAGTAACTCTTGGCA	0.408000													6	31					0	0	1	0	0
OR5B3	441608	broad.mit.edu	37	11	58170132	58170132	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:58170132C>T	ENST00000309403.2	-	1	750	c.751G>A	c.(751-753)Ggg>Agg	p.G251R		NM_001005469.1	NP_001005469.1	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B, member 3	251					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(1)	34	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				ATAATAGTCCCATAGAAGATG	0.438000													12	34					0	0	1	0	0
ZFX	7543	broad.mit.edu	37	X	24229189	24229189	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:24229189T>C	ENST00000379177.1	+	11	2541	c.2114T>C	c.(2113-2115)cTa>cCa	p.L705P	ZFX_ENST00000338565.3_Missense_Mutation_p.L655P|ZFX_ENST00000379188.3_Missense_Mutation_p.L705P|ZFX_ENST00000539115.1_Missense_Mutation_p.L476P|ZFX_ENST00000540034.1_Missense_Mutation_p.L744P|ZFX_ENST00000304543.5_Missense_Mutation_p.L705P	NM_001178085.1|NM_003410.3	NP_001171556.1|NP_003401.2	P17010	ZFX_HUMAN	zinc finger protein, X-linked	705					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(2)|lung(4)|ovary(2)|prostate(1)	24						CCATTTGTTCTAAGTCGCCAT	0.423000													18	99					0	0	1	0	0
ZNF746	155061	broad.mit.edu	37	7	149174751	149174751	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:149174751C>T	ENST00000340622.3	-	5	896	c.616G>A	c.(616-618)Gcg>Acg	p.A206T	ZNF746_ENST00000458143.2_Missense_Mutation_p.A206T			Q6NUN9	ZN746_HUMAN	zinc finger protein 746	206					negative regulation of transcription, DNA-dependent|neuron death|regulation of cell death|transcription, DNA-dependent	cytoplasm|nucleus	transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			GCTGCCCACGCCTCCACGCCC	0.667000													4	13					0	0	1	0	0
ARRB2	409	broad.mit.edu	37	17	4621972	4621972	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:4621972G>A	ENST00000269260.2	+	10	1005	c.772G>A	c.(772-774)Gaa>Aaa	p.E258K	ARRB2_ENST00000572457.1_Missense_Mutation_p.E66K|ARRB2_ENST00000412477.3_Missense_Mutation_p.E279K|ARRB2_ENST00000574954.1_Missense_Mutation_p.E66K|ARRB2_ENST00000381488.6_Missense_Mutation_p.E243K|ARRB2_ENST00000571206.1_Missense_Mutation_p.E66K|ARRB2_ENST00000346341.2_Missense_Mutation_p.E243K|ARRB2_ENST00000575877.1_Missense_Mutation_p.E258K	NM_001257328.1|NM_001257330.1|NM_004313.3	NP_001244257.1|NP_001244259.1|NP_004304.1	P32121	ARRB2_HUMAN	arrestin, beta 2	258	Interaction with TRAF6.				cell chemotaxis|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|G-protein coupled receptor internalization|negative regulation of natural killer cell mediated cytotoxicity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|transcription from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway	coated pit|cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	angiotensin receptor binding|ubiquitin protein ligase binding			large_intestine(1)|liver(2)|lung(3)|prostate(1)	7						GGCTCAACTCGAACAAGAGTG	0.552000													5	45					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129909975	129909975	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr10:129909975G>A	ENST00000368654.3	-	11	2569	c.2194C>T	c.(2194-2196)Cga>Tga	p.R732*	MKI67_ENST00000368653.3_Nonsense_Mutation_p.R372*|MKI67_ENST00000484853.1_5'UTR	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	732					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CTGTAGGGTCGAGCAGGCACA	0.388000													10	84					0	0	1	0	0
ATP2C2	9914	broad.mit.edu	37	16	84476142	84476142	+	Silent	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr16:84476142C>A	ENST00000416219.2	+	15	1427	c.1338C>A	c.(1336-1338)gtC>gtA	p.V446V	ATP2C2_ENST00000420010.2_3'UTR|ATP2C2_ENST00000262429.4_Silent_p.V446V			O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	446					ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(3)|skin(5)|urinary_tract(1)	33						ACAATGCGGTCATCAGAAAGA	0.557000													10	169					1.08611e-07	1.44585e-07	1	1	0
OR6C68	403284	broad.mit.edu	37	12	55886809	55886809	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:55886809C>A	ENST00000379662.1	+	1	663	c.663C>A	c.(661-663)taC>taA	p.Y221*	RP11-110A12.2_ENST00000556750.1_RNA|OR6C68_ENST00000548615.1_Nonsense_Mutation_p.Y216*|RP11-110A12.2_ENST00000554049.1_RNA|RP11-110A12.2_ENST00000555138.1_RNA			A6NDL8	O6C68_HUMAN	olfactory receptor, family 6, subfamily C, member 68	216					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	15						TTCTGTCCTACACATATATCA	0.343000													11	28					1.58986e-06	2.05575e-06	1	1	0
AKNAD1	254268	broad.mit.edu	37	1	109363181	109363181	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:109363181C>A	ENST00000370001.3	-	14	2503	c.2235G>T	c.(2233-2235)gaG>gaT	p.E745D	AKNAD1_ENST00000477908.1_5'UTR	NM_152763.4	NP_689976.2	Q5T1N1	AKND1_HUMAN	AKNA domain containing 1	745										breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|prostate(6)|skin(3)|stomach(2)	32						CTGGTGTGGGCTCATGTTCAC	0.343000													12	81					0.0931896	0.0980044	1	1	0
ZFX	7543	broad.mit.edu	37	X	24229192	24229192	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:24229192G>A	ENST00000379177.1	+	11	2544	c.2117G>A	c.(2116-2118)aGt>aAt	p.S706N	ZFX_ENST00000338565.3_Missense_Mutation_p.S656N|ZFX_ENST00000379188.3_Missense_Mutation_p.S706N|ZFX_ENST00000539115.1_Missense_Mutation_p.S477N|ZFX_ENST00000540034.1_Missense_Mutation_p.S745N|ZFX_ENST00000304543.5_Missense_Mutation_p.S706N	NM_001178085.1|NM_003410.3	NP_001171556.1|NP_003401.2	P17010	ZFX_HUMAN	zinc finger protein, X-linked	706					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(2)|lung(4)|ovary(2)|prostate(1)	24						TTTGTTCTAAGTCGCCATATT	0.418000													21	99					0	0	1	0	0
LEO1	123169	broad.mit.edu	37	15	52258023	52258023	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr15:52258023G>C	ENST00000299601.5	-	2	797	c.737C>G	c.(736-738)tCt>tGt	p.S246C	LEO1_ENST00000315141.5_Missense_Mutation_p.S246C	NM_138792.2	NP_620147.1	Q8WVC0	LEO1_HUMAN	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	246	Asp-rich.				histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|skin(1)	14				all cancers(107;0.00264)		TTCATCATCAGAATTTTGCAT	0.403000													13	140					0	0	1	0	0
GTF2H3	2967	broad.mit.edu	37	12	124130101	124130101	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:124130101C>G	ENST00000543341.2	+	3	224	c.193C>G	c.(193-195)Caa>Gaa	p.Q65E	GTF2H3_ENST00000228955.7_Missense_Mutation_p.Q24E	NM_001271867.1|NM_001516.3	NP_001258796.1|NP_001507.2	Q13889	TF2H3_HUMAN	general transcription factor IIH, polypeptide 3, 34kDa	65					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	core TFIIH complex|holo TFIIH complex	damaged DNA binding|metal ion binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|translation factor activity, nucleic acid binding			breast(2)|endometrium(1)|large_intestine(4)|lung(2)|urinary_tract(1)	10	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.1e-05)|Epithelial(86;0.000388)|all cancers(50;0.00362)		AAGTCACATTCAAGAAAGGTA	0.398000								Nucleotide excision repair (NER)					5	29					0	0	1	0	0
C5AR2	27202	broad.mit.edu	37	19	47844579	47844579	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:47844579C>T	ENST00000595464.1	+	2	741	c.523C>T	c.(523-525)Ctg>Ttg	p.L175L	C5AR2_ENST00000600626.1_Silent_p.L175L|C5AR2_ENST00000257267.2_Silent_p.L175L	NM_001271749.1	NP_001258678.1			complement component 5a receptor 2																		CTACCGCCGGCTGCACCAGGA	0.667000													6	29					0	0	1	0	0
EPM2AIP1	9852	broad.mit.edu	37	3	37032825	37032825	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:37032825C>A	ENST00000322716.5	-	1	1970	c.1744G>T	c.(1744-1746)Gcc>Tcc	p.A582S		NM_014805.3	NP_055620.1	Q7L775	EPMIP_HUMAN	EPM2A (laforin) interacting protein 1	582						endoplasmic reticulum				breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(12)|ovary(2)	27						CGAAACAGGGCTTGGAGATGC	0.413000													9	93					0.000274275	0.000320496	1	1	0
NIPBL	25836	broad.mit.edu	37	5	37000935	37000935	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:37000935G>T	ENST00000282516.8	+	13	4018	c.3519G>T	c.(3517-3519)aaG>aaT	p.K1173N	NIPBL_ENST00000448238.2_Missense_Mutation_p.K1173N	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	1173					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			GGAAAATGAAGAAAAAAGAAA	0.294000													8	63					0.00829132	0.00913058	1	1	0
RNF114	55905	broad.mit.edu	37	20	48565831	48565831	+	Missense_Mutation	SNP	G	G	A	rs41303809	byFrequency	TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr20:48565831G>A	ENST00000244061.2	+	5	562	c.560G>A	c.(559-561)cGc>cAc	p.R187H		NM_018683.3	NP_061153.1	Q9Y508	RN114_HUMAN	ring finger protein 114	187					cell differentiation|multicellular organismal development|spermatogenesis	intracellular	zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(1)|ovary(1)	5						CCCAACTACCGCAGCGCCAAC	0.562000													14	69					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22154795	22154795	+	Nonsense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:22154795G>C	ENST00000397126.4	-	4	3189	c.3041C>G	c.(3040-3042)tCa>tGa	p.S1014*	ZNF208_ENST00000601773.1_Intron|ZNF208_ENST00000599916.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				CATAAGGTTTGATGACCAGTT	0.398000													18	96					0	0	1	0	0
PDIA6	10130	broad.mit.edu	37	2	10929079	10929079	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:10929079G>T	ENST00000404371.2	-	11	1362	c.1025C>A	c.(1024-1026)aCg>aAg	p.T342K	PDIA6_ENST00000381611.4_Missense_Mutation_p.T295K|PDIA6_ENST00000272227.3_Missense_Mutation_p.T290K|PDIA6_ENST00000404824.2_Missense_Mutation_p.T338K|PDIA6_ENST00000540494.1_Missense_Mutation_p.T287K	NM_001282704.1	NP_001269633.1	Q15084	PDIA6_HUMAN	protein disulfide isomerase family A, member 6	290					cell redox homeostasis|glycerol ether metabolic process|protein folding	endoplasmic reticulum lumen|ER-Golgi intermediate compartment|melanosome|plasma membrane	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|prostate(2)	18	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.149)|OV - Ovarian serous cystadenocarcinoma(76;0.15)		CTCCTCACACGTCCTCTTGGC	0.483000													13	46					4.3838e-07	5.76287e-07	1	1	0
PAPPA	5069	broad.mit.edu	37	9	119094669	119094669	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr9:119094669G>T	ENST00000328252.3	+	12	3688	c.3319G>T	c.(3319-3321)Ggg>Tgg	p.G1107W	PAPPA_ENST00000534838.1_Missense_Mutation_p.G145W	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	1107					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						GGTGACGGATGGGACATATTA	0.498000													3	58					0.115264	0.120019	1	1	0
SLC26A10	65012	broad.mit.edu	37	12	58014157	58014157	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:58014157C>A	ENST00000379218.2	+	1	465	c.154C>A	c.(154-156)Ccg>Acg	p.P52T	SLC26A10_ENST00000320442.4_Missense_Mutation_p.P52T			Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	52						integral to membrane	antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(7)	19	Melanoma(17;0.122)					CTCCGTGCCCCCGGTGTTTGG	0.557000													35	393					1.47244e-24	2.08789e-24	1	1	0
AMHR2	269	broad.mit.edu	37	12	53825187	53825187	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:53825187G>A	ENST00000257863.4	+	11	1732	c.1652G>A	c.(1651-1653)tGc>tAc	p.C551Y	AMHR2_ENST00000550311.1_3'UTR|AMHR2_ENST00000379791.3_Missense_Mutation_p.C456Y	NM_001164690.1|NM_020547.2	NP_001158162.1|NP_065434.1	Q16671	AMHR2_HUMAN	anti-Mullerian hormone receptor, type II	551					Mullerian duct regression		ATP binding|hormone binding|metal ion binding			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|skin(2)	34					Adenosine triphosphate(DB00171)	CGGAGTGCCTGCCACTTCAGC	0.542000													9	29					0	0	1	0	0
FAM46C	54855	broad.mit.edu	37	1	118166382	118166382	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:118166382G>A	ENST00000369448.3	+	2	1139	c.892G>A	c.(892-894)Gaa>Aaa	p.E298K		NM_017709.3	NP_060179.2	Q5VWP2	FA46C_HUMAN	family with sequence similarity 46, member C	298										endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	15	Lung SC(450;0.225)	all_cancers(81;0.000101)|all_lung(203;3.4e-06)|all_epithelial(167;4.98e-06)|Lung NSC(69;2.33e-05)		Lung(183;0.0576)|LUSC - Lung squamous cell carcinoma(189;0.192)|Colorectal(144;0.247)		CCACTTCGCTGAAGAAGAGAG	0.512000			"""Mis, F, O"""		MM					Multiple Myeloma(3;1.13e-06)			3	15					0	0	1	0	0
DHRS7C	201140	broad.mit.edu	37	17	9683242	9683242	+	Silent	SNP	A	A	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:9683242A>G	ENST00000330255.5	-	3	393	c.381T>C	c.(379-381)aaT>aaC	p.N127N	DHRS7C_ENST00000571134.1_Silent_p.N126N	NM_001105571.2|NM_001220493.1	NP_001099041.1|NP_001207422.1	A6NNS2	DRS7C_HUMAN	dehydrogenase/reductase (SDR family) member 7C							extracellular region	binding|oxidoreductase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)	15						TCACACTGGCATTGTTGATGA	0.493000													7	15					0	0	1	0	0
SNAP25	6616	broad.mit.edu	37	20	10273881	10273881	+	Missense_Mutation	SNP	C	C	T	rs1051276		TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr20:10273881C>T	ENST00000254976.2	+	5	447	c.236C>T	c.(235-237)aCg>aTg	p.T79M	SNAP25_ENST00000304886.2_Intron|SNAP25-AS1_ENST00000453544.1_RNA|SNAP25-AS1_ENST00000421143.2_RNA	NM_130811.2	NP_570824.1	P60880	SNP25_HUMAN	synaptosomal-associated protein, 25kDa	79	t-SNARE coiled-coil homology 1.				energy reserve metabolic process|glutamate secretion|neurotransmitter uptake|synaptic vesicle docking involved in exocytosis	cell junction|growth cone|perinuclear region of cytoplasm|synapse|synaptosome		p.T79M(1)		endometrium(1)|large_intestine(2)|lung(8)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	18					Botulinum Toxin Type A(DB00083)	AAGAATTTGACGGACCTAGGA	0.458000													4	80					0	0	1	0	0
MRPL18	29074	broad.mit.edu	37	6	160218457	160218457	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr6:160218457G>C	ENST00000367034.4	+	3	500	c.378G>C	c.(376-378)gaG>gaC	p.E126D	MRPL18_ENST00000480842.1_3'UTR	NM_014161.3	NP_054880.2	Q9H0U6	RM18_HUMAN	mitochondrial ribosomal protein L18	126					rRNA transport|translation	mitochondrial ribosome	5S rRNA binding|structural constituent of ribosome			cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)	11		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.44e-18)|BRCA - Breast invasive adenocarcinoma(81;5.79e-06)		TGGCTTGTGAGAGTATAGGAC	0.502000													3	44					0	0	1	0	0
RSF1	51773	broad.mit.edu	37	11	77412518	77412518	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:77412518C>G	ENST00000308488.6	-	6	2058	c.1756G>C	c.(1756-1758)Gaa>Caa	p.E586Q	RSF1_ENST00000480887.1_Missense_Mutation_p.E334Q|RSF1_ENST00000360355.2_Missense_Mutation_p.E555Q			Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	586					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(9)|lung(14)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			TCTAACTTTTCAAGACATTCT	0.398000													16	164					0	0	1	0	0
NUTM2A	728118	broad.mit.edu	37	10	88994220	88994220	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr10:88994220C>T	ENST00000381707.2	+	7	2775	c.2392C>T	c.(2392-2394)Cat>Tat	p.H798Y	NUTM2A-AS1_ENST00000451940.2_RNA|NUTM2A_ENST00000381689.4_Intron	NM_001099338.1	NP_001092808.1			NUT family member 2A																		CCAGGGAACTCATCAGTTCCC	0.597000													4	25					0	0	1	0	0
ITGB4	3691	broad.mit.edu	37	17	73727425	73727425	+	Silent	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:73727425C>G	ENST00000200181.3	+	10	1378	c.1191C>G	c.(1189-1191)tcC>tcG	p.S397S	ITGB4_ENST00000450894.3_Silent_p.S397S|ITGB4_ENST00000579662.1_Silent_p.S397S|ITGB4_ENST00000449880.2_Silent_p.S397S|ITGB4_ENST00000584558.1_3'UTR|ITGB4_ENST00000339591.3_Silent_p.S397S	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	397					cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGACTGGGTCCTTTCACATCC	0.637000													10	44					0	0	1	0	0
PARK2	5071	broad.mit.edu	37	6	162683621	162683621	+	Silent	SNP	A	A	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr6:162683621A>G	ENST00000366898.1	-	3	450	c.348T>C	c.(346-348)tcT>tcC	p.S116S	PARK2_ENST00000366892.1_Silent_p.S116S|PARK2_ENST00000366894.1_Intron|PARK2_ENST00000366896.1_Intron|PARK2_ENST00000338468.3_5'UTR|PARK2_ENST00000366897.1_Silent_p.S116S	NM_004562.2	NP_004553.2	O60260	PRKN2_HUMAN	parkin RBR E3 ubiquitin protein ligase	116					aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		CCAGCCCCACAGAGTCTCCTG	0.577000													4	51					0	0	1	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212478	26212478	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:26212478G>T	ENST00000379034.1	+	2	664	c.515G>T	c.(514-516)gGt>gTt	p.G172V		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	172				G -> R (in Ref. 1; BAC05102).						breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						GCTGCCGAGGGTGAAGATGAG	0.507000													8	47					0.0381472	0.0402523	1	1	0
FAT2	2196	broad.mit.edu	37	5	150901461	150901461	+	Missense_Mutation	SNP	T	T	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:150901461T>A	ENST00000261800.5	-	18	10705	c.10693A>T	c.(10693-10695)Acc>Tcc	p.T3565S		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	3565	Cadherin 32.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGGCTATAGGTCAGCGTGTCC	0.597000													6	14					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77455050	77455050	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr9:77455050C>A	ENST00000451710.3	-	5	671	c.434G>T	c.(433-435)gGc>gTc	p.G145V	TRPM6_ENST00000376864.4_Missense_Mutation_p.G145V|TRPM6_ENST00000360774.1_Missense_Mutation_p.G145V|TRPM6_ENST00000359047.2_Missense_Mutation_p.G145V|TRPM6_ENST00000449912.2_Missense_Mutation_p.G140V|TRPM6_ENST00000376871.3_Missense_Mutation_p.G145V|TRPM6_ENST00000361255.3_Missense_Mutation_p.G140V|TRPM6_ENST00000376872.3_Missense_Mutation_p.G145V			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	145					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						GTTCTGGATGCCCCCATGGAC	0.398000													4	54					1	1	1	1	0
APAF1	317	broad.mit.edu	37	12	99056532	99056532	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:99056532G>T	ENST00000357310.1	+	7	1480	c.903G>T	c.(901-903)atG>atT	p.M301I	APAF1_ENST00000552268.1_Missense_Mutation_p.M301I|APAF1_ENST00000359972.2_Missense_Mutation_p.M290I|APAF1_ENST00000551964.1_Missense_Mutation_p.M301I|APAF1_ENST00000550527.1_Missense_Mutation_p.M290I|APAF1_ENST00000339433.3_Missense_Mutation_p.M301I|APAF1_ENST00000547045.1_Missense_Mutation_p.M301I|APAF1_ENST00000549007.1_Missense_Mutation_p.M301I|APAF1_ENST00000333991.1_Missense_Mutation_p.M301I	NM_181868.1	NP_863658.1	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1	301	NB-ARC.				activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(1)	42					Adenosine triphosphate(DB00171)	TTGTTAATATGAAGAAGGCAG	0.318000													7	32					0.00198382	0.00223934	1	1	0
CNTN1	1272	broad.mit.edu	37	12	41337455	41337455	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:41337455G>C	ENST00000551295.2	+	13	1553	c.1436G>C	c.(1435-1437)gGa>gCa	p.G479A	CNTN1_ENST00000348761.2_Missense_Mutation_p.G468A|CNTN1_ENST00000547702.1_Missense_Mutation_p.G479A|CNTN1_ENST00000347616.1_Missense_Mutation_p.G479A|CNTN1_ENST00000547849.1_Missense_Mutation_p.G479A|CNTN1_ENST00000360099.3_Missense_Mutation_p.G479A	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	479	Ig-like C2-type 5.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				AGGAATGATGGAGGTATCTAT	0.333000													8	74					0	0	1	0	0
EIF4G1	1981	broad.mit.edu	37	3	184039813	184039813	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:184039813G>C	ENST00000342981.4	+	9	1855	c.1441G>C	c.(1441-1443)Gag>Cag	p.E481Q	EIF4G1_ENST00000319274.6_Missense_Mutation_p.E481Q|EIF4G1_ENST00000435046.2_Missense_Mutation_p.E285Q|EIF4G1_ENST00000346169.2_Missense_Mutation_p.E481Q|EIF4G1_ENST00000382330.3_Missense_Mutation_p.E488Q|EIF4G1_ENST00000434061.2_Missense_Mutation_p.E285Q|EIF4G1_ENST00000424196.1_Missense_Mutation_p.E488Q|EIF4G1_ENST00000414031.1_Missense_Mutation_p.E441Q|EIF4G1_ENST00000441154.1_Missense_Mutation_p.E317Q|EIF4G1_ENST00000427845.1_Missense_Mutation_p.E394Q|EIF4G1_ENST00000350481.5_Missense_Mutation_p.E317Q|EIF4G1_ENST00000392537.2_Missense_Mutation_p.E394Q|EIF4G1_ENST00000352767.3_Missense_Mutation_p.E488Q|EIF2B5_ENST00000444495.1_Intron|EIF4G1_ENST00000411531.1_Missense_Mutation_p.E441Q	NM_182917.4	NP_886553	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4 gamma, 1	481					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(5)|large_intestine(14)|lung(41)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	75	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GAAAGGAGGAGAGGAACTGCT	0.527000													5	32					0	0	1	0	0
GNAQ	2776	broad.mit.edu	37	9	80409447	80409447	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr9:80409447C>T	ENST00000286548.4	-	5	889	c.667G>A	c.(667-669)Gtc>Atc	p.V223I	GNAQ_ENST00000397476.3_Missense_Mutation_p.V21I	NM_002072.3	NP_002063.2	P50148	GNAQ_HUMAN	guanine nucleotide binding protein (G protein), q polypeptide	223					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|glutamate signaling pathway|negative regulation of protein kinase activity|platelet activation|protein ADP-ribosylation|protein stabilization|regulation of action potential|regulation of catenin import into nucleus	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activator activity|GTPase activity|signal transducer activity			NS(1)|endometrium(3)|eye(229)|kidney(1)|large_intestine(4)|lung(6)|meninges(11)|ovary(1)|prostate(1)|skin(44)|upper_aerodigestive_tract(1)	302						ATAGAGGTGACATTTTCAAAG	0.383000			Mis		uveal melanoma								7	67					0	0	1	0	0
EPHA1	2041	broad.mit.edu	37	7	143095498	143095498	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:143095498C>T	ENST00000275815.3	-	7	1466	c.1380G>A	c.(1378-1380)ccG>ccA	p.P460P		NM_005232.4	NP_005223.4	P21709	EPHA1_HUMAN	EPH receptor A1	460	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(21)|ovary(4)|skin(1)|stomach(1)|urinary_tract(3)	51	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				CTAGTTGCCTCGGTTCTTTCT	0.552000													6	38					0	0	1	0	0
DPEP1	1800	broad.mit.edu	37	16	89696854	89696854	+	Silent	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr16:89696854C>G	ENST00000393092.3	+	2	327	c.36C>G	c.(34-36)gcC>gcG	p.A12A	DPEP1_ENST00000261615.4_Silent_p.A12A|DPEP1_ENST00000421184.1_Silent_p.A12A	NM_004413.3	NP_004404.1	P16444	DPEP1_HUMAN	dipeptidase 1 (renal)	12					proteolysis	anchored to membrane|apical plasma membrane|microvillus membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity|protein binding			large_intestine(2)|lung(10)|prostate(1)|urinary_tract(1)	14		all_lung(18;0.0054)|all_hematologic(23;0.094)		BRCA - Breast invasive adenocarcinoma(80;0.0258)	Cilastatin(DB01597)	CCCTTGTGGCCGTCTGCACTG	0.642000													13	44					0	0	1	0	0
ZFP37	7539	broad.mit.edu	37	9	115805098	115805098	+	Silent	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr9:115805098G>T	ENST00000374227.3	-	4	1827	c.1800C>A	c.(1798-1800)ccC>ccA	p.P600P	ZFP37_ENST00000555206.1_Silent_p.P601P|ZFP37_ENST00000553380.1_Silent_p.P615P	NM_001282515.1|NM_001282518.1	NP_001269444.1|NP_001269447.1	Q9Y6Q3	ZFP37_HUMAN	ZFP37 zinc finger protein	600						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						TACATTCATAGGGTTTTTCTC	0.353000													5	73					0.014758	0.0160005	1	1	0
TNFAIP8L1	126282	broad.mit.edu	37	19	4652064	4652064	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:4652064G>C	ENST00000536716.1	+	2	329	c.183G>C	c.(181-183)aaG>aaC	p.K61N	TNFAIP8L1_ENST00000327473.4_Missense_Mutation_p.K61N	NM_001167942.1	NP_001161414.1	Q8WVP5	TP8L1_HUMAN	tumor necrosis factor, alpha-induced protein 8-like 1	61										endometrium(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		AGATGCTCAAGAACCTGGTCA	0.677000													4	7					0	0	1	0	0
MRPL32	64983	broad.mit.edu	37	7	42974729	42974729	+	Silent	SNP	A	A	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:42974729A>G	ENST00000223324.2	+	2	493	c.306A>G	c.(304-306)aaA>aaG	p.K102K	MRPL32_ENST00000496564.1_3'UTR	NM_031903.2	NP_114109.1	Q9BYC8	RM32_HUMAN	mitochondrial ribosomal protein L32	102					translation	large ribosomal subunit|mitochondrial ribosome	structural constituent of ribosome			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)	10						AGCTTATTAAAGTTAAGGTAA	0.398000													11	39					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54604057	54604057	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:54604057C>T	ENST00000474759.1	+	8	862	c.814C>T	c.(814-816)Ctg>Ttg	p.L272L	CACNA2D3_ENST00000490478.1_Silent_p.L178L|CACNA2D3_ENST00000415676.2_Silent_p.L272L|CACNA2D3_ENST00000288197.5_Silent_p.L272L	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	272	VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		AGGACTCCGTCTGACTATCGC	0.453000													4	106					0	0	1	0	0
KIF24	347240	broad.mit.edu	37	9	34257592	34257592	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr9:34257592C>G	ENST00000379166.2	-	11	2132	c.2013G>C	c.(2011-2013)gaG>gaC	p.E671D	KIF24_ENST00000379174.3_Missense_Mutation_p.E537D|KIF24_ENST00000345050.2_Missense_Mutation_p.E537D|KIF24_ENST00000402558.2_Missense_Mutation_p.E671D	NM_194313.2	NP_919289.2	Q5T7B8	KIF24_HUMAN	kinesin family member 24	671					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|liver(1)|lung(13)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	32			LUSC - Lung squamous cell carcinoma(29;0.0107)			TTCGATTTTTCTCAGAGCACA	0.522000													5	92					0	0	1	0	0
RB1CC1	9821	broad.mit.edu	37	8	53597999	53597999	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr8:53597999C>T	ENST00000025008.5	-	3	554	c.31G>A	c.(31-33)Gga>Aga	p.G11R	RB1CC1_ENST00000539297.1_Missense_Mutation_p.G11R|RB1CC1_ENST00000521611.1_Intron|RB1CC1_ENST00000435644.2_Missense_Mutation_p.G11R	NM_014781.4	NP_055596.3	Q8TDY2	RBCC1_HUMAN	RB1-inducible coiled-coil 1	11					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				AGAGTAGTTCCAGTGTTAACC	0.338000													6	117					0	0	1	0	0
TMEM79	84283	broad.mit.edu	37	1	156255629	156255629	+	Silent	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:156255629G>T	ENST00000405535.2	+	2	783	c.612G>T	c.(610-612)gtG>gtT	p.V204V	TMEM79_ENST00000495881.1_3'UTR|TMEM79_ENST00000295694.5_Silent_p.V204V|TMEM79_ENST00000357501.2_Intron	NM_032323.2	NP_115699.1	Q9BSE2	TMM79_HUMAN	transmembrane protein 79	204						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(9)|urinary_tract(1)	21	Hepatocellular(266;0.158)					TGGCCTCCGTGGGAGCCGCAC	0.632000													6	49					0.0215528	0.0229339	1	1	0
MACC1	346389	broad.mit.edu	37	7	20193845	20193845	+	Silent	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:20193845G>T	ENST00000400331.5	-	6	2625	c.2317C>A	c.(2317-2319)Cga>Aga	p.R773R	MACC1_ENST00000332878.4_Silent_p.R773R|MACC1_ENST00000589011.1_Silent_p.R773R	NM_182762.3	NP_877439.3	Q6ZN28	MACC1_HUMAN	metastasis associated in colon cancer 1	773					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			endometrium(1)|kidney(1)|large_intestine(15)|lung(12)|ovary(2)|prostate(1)|skin(3)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(1)	39						GTGTTTCCTCGATGAGGAATT	0.408000													20	67					4.4004e-07	5.77267e-07	1	1	0
NYAP1	222950	broad.mit.edu	37	7	100087190	100087190	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:100087190G>C	ENST00000423930.1	+	4	2005	c.1846G>C	c.(1846-1848)Gag>Cag	p.E616Q	NYAP1_ENST00000454988.1_Missense_Mutation_p.E559Q|NYAP1_ENST00000300179.2_Missense_Mutation_p.E616Q			Q6ZVC0	CG051_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1	616	Poly-Glu.																AGGGACACCAGAGGAGGAAGA	0.612000													8	27					0	0	1	0	0
HMGB3	3149	broad.mit.edu	37	X	150156360	150156360	+	Silent	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:150156360G>A	ENST00000325307.7	+	5	672	c.576G>A	c.(574-576)gaG>gaA	p.E192E	HMGB3_ENST00000448905.2_Silent_p.E192E	NM_005342.2	NP_005333.2	O15347	HMGB3_HUMAN	high mobility group box 3	192	Asp/Glu-rich (acidic).				DNA recombination|multicellular organismal development	chromosome|nucleus	DNA bending activity|double-stranded DNA binding	p.E192E(1)		endometrium(3)|large_intestine(2)|lung(2)|skin(1)	8	Acute lymphoblastic leukemia(192;6.56e-05)					aggaagaagaggaggaggagg	0.443000													4	111					0	0	1	0	0
OPTN	10133	broad.mit.edu	37	10	13152414	13152414	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr10:13152414G>A	ENST00000378748.3	+	5	669	c.307G>A	c.(307-309)Gag>Aag	p.E103K	OPTN_ENST00000482140.1_Intron|OPTN_ENST00000378752.3_Missense_Mutation_p.E103K|OPTN_ENST00000378747.3_Missense_Mutation_p.E103K|OPTN_ENST00000378764.2_Missense_Mutation_p.E103K|OPTN_ENST00000263036.5_Missense_Mutation_p.E103K|OPTN_ENST00000378757.2_Missense_Mutation_p.E103K	NM_001008211.1|NM_001008213.1	NP_001008212|NP_001008214	Q96CV9	OPTN_HUMAN	optineurin	103	Interaction with Rab8.		E -> D (in GLC1E).		cell death|Golgi ribbon formation|Golgi to plasma membrane protein transport|protein targeting to Golgi|signal transduction	perinuclear region of cytoplasm|trans-Golgi network	protein C-terminus binding			breast(1)|endometrium(2)|large_intestine(5)|lung(9)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22						CTTGAGTCATGAGAATGAGAA	0.418000													5	33					0	0	1	0	0
DCUN1D4	23142	broad.mit.edu	37	4	52777312	52777312	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr4:52777312T>C	ENST00000334635.5	+	9	872	c.692T>C	c.(691-693)cTt>cCt	p.L231P	DCUN1D4_ENST00000451288.2_Missense_Mutation_p.L275P|DCUN1D4_ENST00000381437.4_Missense_Mutation_p.L171P|DCUN1D4_ENST00000381441.3_Intron	NM_001040402.1	NP_001035492.1	Q92564	DCNL4_HUMAN	DCN1, defective in cullin neddylation 1, domain containing 4	231	DCUN1.									endometrium(2)|large_intestine(2)|lung(2)|ovary(2)|skin(1)	9			GBM - Glioblastoma multiforme(4;1.93e-11)|LUSC - Lung squamous cell carcinoma(32;0.00654)			ATCTGGCCCCTTTTTCCAGTT	0.383000													3	77					0	0	1	0	0
DAND5	199699	broad.mit.edu	37	19	13080545	13080545	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:13080545C>A	ENST00000317060.2	+	1	250	c.71C>A	c.(70-72)cCt>cAt	p.P24H	DAND5_ENST00000585548.1_Missense_Mutation_p.P54H	NM_152654.2	NP_689867.1	Q8N907	DAND5_HUMAN	DAN domain family member 5, BMP antagonist	24						extracellular region				kidney(2)|lung(3)|ovary(1)	6			OV - Ovarian serous cystadenocarcinoma(19;1.87e-18)			TCAGGGAGGCCTGAACCCCAG	0.647000													12	97					4.3838e-07	5.76287e-07	1	1	0
HSD17B6	8630	broad.mit.edu	37	12	57175932	57175932	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:57175932C>G	ENST00000554643.1	+	4	837	c.488C>G	c.(487-489)tCc>tGc	p.S163C	HSD17B6_ENST00000555805.1_Missense_Mutation_p.S163C|HSD17B6_ENST00000322165.1_Missense_Mutation_p.S163C|HSD17B6_ENST00000554150.1_Missense_Mutation_p.S163C|HSD17B6_ENST00000555159.1_Missense_Mutation_p.S163C			O14756	H17B6_HUMAN	hydroxysteroid (17-beta) dehydrogenase 6	163					androgen biosynthetic process|androgen catabolic process	early endosome membrane|endoplasmic reticulum|microsome	binding|electron carrier activity|estradiol 17-beta-dehydrogenase activity|retinol dehydrogenase activity|testosterone 17-beta-dehydrogenase (NAD+) activity			endometrium(1)|large_intestine(2)|lung(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10					Succinic acid(DB00139)	GTCAATGTCTCCAGCATTCTG	0.438000													8	39					0	0	1	0	0
CUL3	8452	broad.mit.edu	37	2	225360597	225360597	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:225360597C>G	ENST00000264414.4	-	13	2132	c.1794G>C	c.(1792-1794)caG>caC	p.Q598H	CUL3_ENST00000409096.1_Missense_Mutation_p.Q574H|CUL3_ENST00000344951.4_Missense_Mutation_p.Q532H|CUL3_ENST00000409777.1_Missense_Mutation_p.Q574H	NM_003590.4	NP_003581.1	Q13618	CUL3_HUMAN	cullin 3	598					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	46		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		ATATGGTCATCTGGAAAGTGG	0.348000													10	32					0	0	1	0	0
CHRM2	1129	broad.mit.edu	37	7	136700941	136700941	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:136700941C>A	ENST00000445907.2	+	3	1857	c.1329C>A	c.(1327-1329)tgC>tgA	p.C443*	hsa-mir-490_ENST00000593789.1_RNA|hsa-mir-490_ENST00000425981.2_RNA|hsa-mir-490_ENST00000586239.1_RNA|hsa-mir-490_ENST00000592183.1_RNA|CHRM2_ENST00000402486.3_Nonsense_Mutation_p.C443*|CHRM2_ENST00000397608.3_Nonsense_Mutation_p.C443*|hsa-mir-490_ENST00000439694.1_RNA|CHRM2_ENST00000401861.1_Nonsense_Mutation_p.C443*|CHRM2_ENST00000453373.1_Nonsense_Mutation_p.C443*|hsa-mir-490_ENST00000597642.1_RNA|CHRM2_ENST00000320658.5_Nonsense_Mutation_p.C443*|hsa-mir-490_ENST00000598184.1_RNA	NM_001006627.1|NM_001006629.1	NP_001006628.1|NP_001006630.1	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	443					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(13)|liver(1)|lung(29)|ovary(4)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	68					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	ATGCACTTTGCAATGCCACCT	0.423000													8	76					0.000274275	0.000320496	1	1	0
ZNF823	55552	broad.mit.edu	37	19	11834016	11834016	+	Silent	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:11834016C>A	ENST00000341191.6	-	4	486	c.333G>T	c.(331-333)tcG>tcT	p.S111S	ZNF823_ENST00000545749.1_5'UTR|ZNF823_ENST00000440527.1_3'UTR	NM_001080493.2	NP_001073962.1	P16415	ZN823_HUMAN	zinc finger protein 823	111					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)	26						AATTAAGAGACGAATGACCCA	0.428000										HNSCC(68;0.2)			5	50					0.000602214	0.000695966	1	1	0
SNAPC4	6621	broad.mit.edu	37	9	139289816	139289816	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr9:139289816G>C	ENST00000298532.2	-	4	773	c.405C>G	c.(403-405)agC>agG	p.S135R		NM_003086.2	NP_003077.2	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex, polypeptide 4, 190kDa	135					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	33		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		TTGGGGGCAGGCTTTTGCCAT	0.577000													3	35					0	0	1	0	0
IFT81	28981	broad.mit.edu	37	12	110600783	110600783	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:110600783G>C	ENST00000242591.5	+	11	1607	c.1101G>C	c.(1099-1101)gaG>gaC	p.E367D	IFT81_ENST00000361948.4_Missense_Mutation_p.E367D|IFT81_ENST00000552912.1_Missense_Mutation_p.E367D|IFT81_ENST00000549009.1_3'UTR	NM_014055.3	NP_054774.2	Q8WYA0	IFT81_HUMAN	intraflagellar transport 81 homolog (Chlamydomonas)	367					cell differentiation|multicellular organismal development|spermatogenesis	intraflagellar transport particle B|microtubule-based flagellum				endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|stomach(1)	10						AGGCCAAGGAGAAGTTAGCCA	0.403000													6	56					0	0	1	0	0
PSG3	5671	broad.mit.edu	37	19	43233345	43233345	+	Silent	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:43233345G>A	ENST00000327495.5	-	5	1357	c.1173C>T	c.(1171-1173)ctC>ctT	p.L391L	PSG3_ENST00000595140.1_Silent_p.L391L	NM_021016.3	NP_066296.2	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	391	Ig-like C2-type 3.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36		Prostate(69;0.00682)				AGCAAGCATAGAGCCCGCTAT	0.458000													23	187					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	89989985	89989985	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:89989985G>A	ENST00000405460.2	+	33	7508	c.7412G>A	c.(7411-7413)aGc>aAc	p.S2471N		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	2471					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TCATGGATCAGCCCAGCTGTC	0.483000													6	14					0	0	1	0	0
SIX3	6496	broad.mit.edu	37	2	45169361	45169361	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:45169361G>T	ENST00000260653.3	+	1	460	c.118G>T	c.(118-120)Ggc>Tgc	p.G40C		NM_005413.3	NP_005404.1	O95343	SIX3_HUMAN	SIX homeobox 3	40	Poly-Gly.				visual perception	nucleus				haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|skin(1)	11		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				cggtgcgggaggcggcggcgg	0.736000													8	48					0.0381472	0.0402523	1	1	0
DPPA4	55211	broad.mit.edu	37	3	109052769	109052769	+	Silent	SNP	T	T	A	rs150133131		TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:109052769T>A	ENST00000335658.6	-	2	180	c.126A>T	c.(124-126)ccA>ccT	p.P42P	DPPA4_ENST00000478791.1_5'UTR	NM_018189.3	NP_060659.3	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	42						nucleus	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(17)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25						CTGATGTTCCTGGCAAAGCAA	0.448000													3	55					0	0	1	0	0
DZANK1	55184	broad.mit.edu	37	20	18379185	18379185	+	Silent	SNP	T	T	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr20:18379185T>C	ENST00000357236.4	-	15	1835	c.1176A>G	c.(1174-1176)gcA>gcG	p.A392A	DZANK1_ENST00000329494.5_Silent_p.A508A|DZANK1_ENST00000358866.6_Silent_p.A506A|DZANK1_ENST00000487128.1_5'UTR|DZANK1_ENST00000262547.5_Silent_p.A506A			Q9NVP4	CT012_HUMAN	double zinc ribbon and ankyrin repeat domains 1	333						intracellular	zinc ion binding			NS(1)|cervix(1)|endometrium(2)|large_intestine(5)|lung(10)	19						TCCTGGGTTCTGCAATCAAGG	0.507000													17	83					0	0	1	0	0
POLR2A	5430	broad.mit.edu	37	17	7404869	7404869	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:7404869G>A	ENST00000322644.6	+	14	2569	c.2170G>A	c.(2170-2172)Gag>Aag	p.E724K		NM_000937.4	NP_000928	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	724					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				ACACAACAATGAGCTGGAGCC	0.547000													4	44					0	0	1	0	0
FAM209B	388799	broad.mit.edu	37	20	55111292	55111292	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr20:55111292C>A	ENST00000371325.1	+	2	410	c.314C>A	c.(313-315)gCt>gAt	p.A105D		NM_001013646.2	NP_001013668.2	Q5JX69	CT107_HUMAN	family with sequence similarity 209, member B	105						integral to membrane											AATCAAAATGCTTCTCTTTAC	0.403000													9	74					0.000442599	0.000515277	1	1	0
TEX13A	56157	broad.mit.edu	37	X	104464971	104464971	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:104464971C>G	ENST00000372578.3	-	2	222	c.111G>C	c.(109-111)gaG>gaC	p.E37D	TEX13A_ENST00000372575.1_Missense_Mutation_p.E37D|TEX13A_ENST00000413579.1_Missense_Mutation_p.E37D|IL1RAPL2_ENST00000344799.4_Intron|IL1RAPL2_ENST00000372582.1_Intron	NM_031274.3	NP_112564.1	Q9BXU3	TX13A_HUMAN	testis expressed 13A	37						intracellular	zinc ion binding			large_intestine(5)|ovary(2)|upper_aerodigestive_tract(1)	8						AGGATATATTCTCAAGATAGA	0.567000													8	28					0	0	1	0	0
OR10A2	341276	broad.mit.edu	37	11	6891233	6891233	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:6891233G>T	ENST00000307322.4	+	1	310	c.248G>T	c.(247-249)gGc>gTc	p.G83V		NM_001004460.1	NP_001004460.1	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A, member 2	83					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(12)|urinary_tract(1)	24		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		TCCTTCCTTGGCTGTGCCACT	0.507000													40	62					7.05121e-23	9.97604e-23	1	1	0
GSTA4	2941	broad.mit.edu	37	6	52852203	52852203	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr6:52852203C>T	ENST00000370959.1	-	3	208	c.91G>A	c.(91-93)Gat>Aat	p.D31N	GSTA4_ENST00000370960.1_Intron|GSTA4_ENST00000486559.1_5'UTR|GSTA4_ENST00000541324.1_Intron			O15217	GSTA4_HUMAN	glutathione S-transferase alpha 4	31	GST N-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity|protein homodimerization activity			endometrium(1)|lung(3)|skin(2)|urinary_tract(1)	7	Lung NSC(77;0.103)				Glutathione(DB00143)	AATTCTTCATCAAACTAAATT	0.308000													8	106					0	0	1	0	0
TM6SF1	53346	broad.mit.edu	37	15	83791578	83791578	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr15:83791578C>G	ENST00000322019.9	+	6	825	c.551C>G	c.(550-552)gCt>gGt	p.A184G	TM6SF1_ENST00000565774.1_Missense_Mutation_p.A184G|TM6SF1_ENST00000379386.4_Missense_Mutation_p.A187G|TM6SF1_ENST00000379390.6_Intron			Q9BZW5	TM6S1_HUMAN	transmembrane 6 superfamily member 1	184						integral to membrane				endometrium(1)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	15						CCTGTCTGGGCTGGTTTCAGA	0.358000													10	50					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164908343	164908343	+	Missense_Mutation	SNP	T	T	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:164908343T>A	ENST00000475390.1	-	2	719	c.276A>T	c.(274-276)ttA>ttT	p.L92F	SLITRK3_ENST00000241274.3_Missense_Mutation_p.L92F			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	92						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						TGTTGGTATATAATTTCCTCA	0.348000										HNSCC(40;0.11)			4	59					0	0	1	0	0
WDR53	348793	broad.mit.edu	37	3	196281454	196281454	+	Silent	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:196281454C>A	ENST00000332629.5	-	4	1272	c.705G>T	c.(703-705)ctG>ctT	p.L235L	WDR53_ENST00000433160.1_Silent_p.L76L|WDR53_ENST00000429115.1_Silent_p.L74L	NM_182627.1	NP_872433.1	Q7Z5U6	WDR53_HUMAN	WD repeat domain 53	235										breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)	13	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.6e-23)|all cancers(36;1.54e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.29e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		CCTTAAATCCCAGTTCCTGTT	0.473000													11	131					3.07112e-06	3.93078e-06	1	1	0
PHTF2	57157	broad.mit.edu	37	7	77558466	77558466	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:77558466C>T	ENST00000416283.2	+	10	1184	c.1058C>T	c.(1057-1059)tCa>tTa	p.S353L	PHTF2_ENST00000275575.7_Missense_Mutation_p.S349L|PHTF2_ENST00000307305.8_Missense_Mutation_p.S349L|PHTF2_ENST00000424760.1_Missense_Mutation_p.S349L|PHTF2_ENST00000422959.2_Missense_Mutation_p.S353L|PHTF2_ENST00000454592.1_3'UTR|PHTF2_ENST00000248550.7_Missense_Mutation_p.S387L	NM_001127357.1|NM_020432.4	NP_001120829.1|NP_065165.3	Q8N3S3	PHTF2_HUMAN	putative homeodomain transcription factor 2	387					regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleus	DNA binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	19						TCTCGCTGTTCAAGTTCCAGA	0.408000													4	18					0	0	1	0	0
GLIS3	169792	broad.mit.edu	37	9	4125879	4125879	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr9:4125879C>A	ENST00000381971.3	-	3	1044	c.451G>T	c.(451-453)Gtc>Ttc	p.V151F	GLIS3_ENST00000324333.10_5'UTR	NM_001042413.1	NP_001035878.1	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3	0	Ser-rich.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(12)|lung(4)|ovary(2)|prostate(1)|skin(1)	26		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		CTGCTGGTGACCACTAGATTG	0.498000													29	36					3.73988e-18	5.27934e-18	1	1	0
CNTNAP4	85445	broad.mit.edu	37	16	76587765	76587765	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr16:76587765C>A	ENST00000307431.8	+	24	4076	c.3691C>A	c.(3691-3693)Ctt>Att	p.L1231I	CNTNAP4_ENST00000478060.1_Missense_Mutation_p.L1159I|CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000377504.4_Missense_Mutation_p.L1183I|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.L1235I|RP11-58C22.1_ENST00000563764.1_Missense_Mutation_p.L40I	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	1232					cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						CAGAGAGCCCCTTGCTAATGC	0.358000													4	16					1.23904e-05	1.53602e-05	1	1	0
COLEC11	78989	broad.mit.edu	37	2	3691547	3691547	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:3691547C>A	ENST00000403096.3	+	6	1068	c.577C>A	c.(577-579)Cac>Aac	p.H193N	COLEC11_ENST00000382062.2_Missense_Mutation_p.H195N|COLEC11_ENST00000349077.4_Missense_Mutation_p.H219N|COLEC11_ENST00000402922.1_Missense_Mutation_p.H169N|COLEC11_ENST00000402794.1_Missense_Mutation_p.H169N|COLEC11_ENST00000236693.7_Missense_Mutation_p.H216N|COLEC11_ENST00000404205.1_Missense_Mutation_p.H145N|COLEC11_ENST00000487365.1_3'UTR|COLEC11_ENST00000418971.2_Missense_Mutation_p.H233N	NM_001255986.1	NP_001242915.1	Q9BWP8	COL11_HUMAN	collectin sub-family member 11	219	C-type lectin.					collagen	mannose binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|soft_tissue(1)	22	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.127)		GTACTCTGACCACTCCCCCAT	0.637000													6	33					0.0215528	0.0229339	1	1	0
LRRC41	10489	broad.mit.edu	37	1	46746110	46746110	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:46746110C>T	ENST00000343304.6	-	6	2164	c.1879G>A	c.(1879-1881)Gcc>Acc	p.A627T	LRRC41_ENST00000472710.1_5'UTR	NM_006369.4	NP_006360.3	Q15345	LRC41_HUMAN	leucine rich repeat containing 41	627										breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(7)|ovary(3)|pancreas(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	28	Acute lymphoblastic leukemia(166;0.155)					TGGGGAGAGGCAAAGGTGGCA	0.577000													7	56					0	0	1	0	0
YY1	7528	broad.mit.edu	37	14	100728701	100728701	+	Nonsense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr14:100728701C>G	ENST00000262238.4	+	2	1000	c.740C>G	c.(739-741)tCa>tGa	p.S247*		NM_003403.3	NP_003394.1	P25490	TYY1_HUMAN	YY1 transcription factor	247					cell differentiation|cellular response to UV|double-strand break repair via homologous recombination|negative regulation of transcription from RNA polymerase II promoter|response to UV-C|spermatogenesis	Ino80 complex|nuclear matrix|plasma membrane	four-way junction DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			cervix(1)|endometrium(1)|large_intestine(1)|liver(2)|lung(1)|prostate(4)|skin(1)	11		Melanoma(154;0.152)				GGAGAGAACTCACCTCCTGAT	0.388000													4	67					0	0	1	0	0
ARMC2	84071	broad.mit.edu	37	6	109215684	109215684	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr6:109215684G>T	ENST00000392644.4	+	6	854	c.686G>T	c.(685-687)aGa>aTa	p.R229I	ARMC2_ENST00000368972.3_Missense_Mutation_p.R64I	NM_032131.4	NP_115507.4	Q8NEN0	ARMC2_HUMAN	armadillo repeat containing 2	229							binding			endometrium(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(1)|skin(1)	24		all_cancers(87;1.14e-07)|Acute lymphoblastic leukemia(125;2.3e-10)|all_hematologic(75;3.3e-08)|all_epithelial(87;0.000111)|Colorectal(196;0.03)|all_lung(197;0.11)		Epithelial(106;0.000197)|BRCA - Breast invasive adenocarcinoma(108;0.000236)|all cancers(137;0.000279)|OV - Ovarian serous cystadenocarcinoma(136;0.00434)		CAGGGGAAGAGACATGCGAGG	0.483000													6	40					2.7689e-08	3.7493e-08	1	1	0
PIAS3	10401	broad.mit.edu	37	1	145578392	145578392	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:145578392C>T	ENST00000393045.2	+	2	445	c.355C>T	c.(355-357)Ctg>Ttg	p.L119L	PIAS3_ENST00000369298.1_Intron|PIAS3_ENST00000369299.3_Silent_p.L110L	NM_006099.3	NP_006090.2	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	119	PINIT.|Pro-rich.				positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)	28	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GCACCCCCCTCTGCCCCAGCC	0.617000													3	53					0	0	1	0	0
TUBA3D	113457	broad.mit.edu	37	2	132240253	132240253	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:132240253C>T	ENST00000321253.6	+	5	1292	c.1185C>T	c.(1183-1185)ttC>ttT	p.F395F		NM_080386.3	NP_525125.2	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	395					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32				BRCA - Breast invasive adenocarcinoma(221;0.13)		ACCATAAGTTCGATCTCATGT	0.642000													5	120					0	0	1	0	0
CATSPER2P1	440278	broad.mit.edu	37	15	44028362	44028362	+	RNA	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr15:44028362C>T	ENST00000381680.2	-	0	1422					NR_002318.2																						CCTTGAGGGCCCTGACCAGGA	0.488000													11	163					0	0	1	0	0
SPAG4	6676	broad.mit.edu	37	20	34208665	34208665	+	Silent	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr20:34208665G>A	ENST00000374273.3	+	11	1249	c.1137G>A	c.(1135-1137)gaG>gaA	p.E379E		NM_003116.1	NP_003107.1	Q9NPE6	SPAG4_HUMAN	sperm associated antigen 4	379	SUN.				spermatogenesis	cilium|flagellar axoneme|integral to membrane	structural molecule activity	p.E379D(1)		NS(1)|cervix(5)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)	21	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			TCGATGTTGAGAAATCGGAGA	0.507000													14	90					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140188665	140188665	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:140188665C>G	ENST00000530339.1	+	1	1893	c.1893C>G	c.(1891-1893)atC>atG	p.I631M	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000356878.4_Missense_Mutation_p.I631M|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000512229.2_Missense_Mutation_p.I631M|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGCGAGATCAGCACAACGC	0.682000													4	69					0	0	1	0	0
GOLM1	51280	broad.mit.edu	37	9	88650475	88650475	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr9:88650475C>A	ENST00000388712.3	-	8	991	c.823G>T	c.(823-825)Ggc>Tgc	p.G275C	GOLM1_ENST00000388711.3_Missense_Mutation_p.G275C	NM_016548.3	NP_057632.2	Q8NBJ4	GOLM1_HUMAN	golgi membrane protein 1	275						Golgi apparatus|integral to plasma membrane				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	17						TGCTCCCGGCCTGGCTCCTGC	0.612000											OREG0019278	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	147					0.0215528	0.0229339	1	1	0
ZBTB12	221527	broad.mit.edu	37	6	31868052	31868052	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr6:31868052C>T	ENST00000375527.2	-	2	1206	c.1031G>A	c.(1030-1032)gGc>gAc	p.G344D	C2_ENST00000469372.1_Intron	NM_181842.2	NP_862825.1	Q9Y330	ZBT12_HUMAN	zinc finger and BTB domain containing 12	344					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|lung(5)|prostate(1)|skin(1)	10						CTTCTCCACGCCCTGGAACAC	0.622000													3	30					0	0	1	0	0
ZNF43	7594	broad.mit.edu	37	19	21991595	21991595	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:21991595T>C	ENST00000594012.1	-	7	1740	c.1226A>G	c.(1225-1227)gAa>gGa	p.E409G	ZNF43_ENST00000354959.4_Missense_Mutation_p.E415G|ZNF43_ENST00000595461.1_Missense_Mutation_p.E409G|ZNF43_ENST00000598381.1_Missense_Mutation_p.E409G	NM_001256649.1|NM_001256651.1|NM_001256653.1|NM_001256654.1	NP_001243578.1|NP_001243580.1|NP_001243582.1|NP_001243583.1	P17038	ZNF43_HUMAN	zinc finger protein 43	415					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	51		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		TAACTTATGTTCAGTAAGCTT	0.363000													5	152					0	0	1	0	0
SF3A1	10291	broad.mit.edu	37	22	30741131	30741131	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr22:30741131G>A	ENST00000215793.8	-	4	596	c.442C>T	c.(442-444)Cct>Tct	p.P148S	SF3A1_ENST00000439242.1_Intron	NM_005877.4	NP_005868.1	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa						nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|urinary_tract(1)	29						TCAAACTCAGGAGGAGGCTCT	0.542000													3	19					0	0	1	0	0
NUTM2A	728118	broad.mit.edu	37	10	88994223	88994223	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr10:88994223C>T	ENST00000381707.2	+	7	2778	c.2395C>T	c.(2395-2397)Cag>Tag	p.Q799*	NUTM2A-AS1_ENST00000451940.2_RNA|NUTM2A_ENST00000381689.4_Intron	NM_001099338.1	NP_001092808.1			NUT family member 2A																		GGGAACTCATCAGTTCCCATC	0.592000													4	26					0	0	1	0	0
NUP98	4928	broad.mit.edu	37	11	3721910	3721910	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:3721910C>T	ENST00000324932.7	-	24	4092	c.3672G>A	c.(3670-3672)ctG>ctA	p.L1224L	NUP98_ENST00000355260.3_Silent_p.L1224L|NUP98_ENST00000359171.4_Silent_p.L1224L	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	1241					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		CAGCAACTCCCAGATTGGGGA	0.413000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								16	47					0	0	1	0	0
GPR15	2838	broad.mit.edu	37	3	98251957	98251957	+	Silent	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:98251957C>G	ENST00000284311.3	+	1	1215	c.1080C>G	c.(1078-1080)ctC>ctG	p.L360L		NM_005290.1	NP_005281.1	P49685	GPR15_HUMAN	G protein-coupled receptor 15	360						integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(1)|kidney(3)|large_intestine(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Lung NSC(201;7.93e-06)|all_neural(597;0.00172)|Hepatocellular(537;0.00825)|Myeloproliferative disorder(1037;0.0255)		Lung(72;0.246)		CTGTGTCACTCTAAAGGGAAC	0.433000													3	38					0	0	1	0	0
XYLT1	64131	broad.mit.edu	37	16	17221624	17221624	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr16:17221624C>A	ENST00000261381.6	-	10	2206	c.2122G>T	c.(2122-2124)Gct>Tct	p.A708S		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	708					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TTGCTCACAGCCAGATTGGTA	0.512000													13	107					0.000151284	0.000181139	1	1	0
NFE2L2	4780	broad.mit.edu	37	2	178098960	178098960	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:178098960C>G	ENST00000397062.3	-	2	639	c.85G>C	c.(85-87)Gat>Cat	p.D29H	NFE2L2_ENST00000423513.1_Missense_Mutation_p.D13H|NFE2L2_ENST00000446151.2_Missense_Mutation_p.D13H|NFE2L2_ENST00000464747.1_Missense_Mutation_p.D13H|NFE2L2_ENST00000397063.4_Missense_Mutation_p.D13H	NM_006164.4	NP_006155.2	Q16236	NF2L2_HUMAN	nuclear factor, erythroid 2-like 2	29					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.D29H(11)|p.D29N(2)|p.D29Y(2)		central_nervous_system(1)|cervix(4)|endometrium(14)|kidney(5)|large_intestine(4)|liver(13)|lung(71)|oesophagus(29)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	158			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			ACTCCAAGATCTATATCTTGC	0.363000			Mis		"""NSCLC, HNSCC"""					HNSCC(56;0.16)			4	51					0	0	1	0	0
PICK1	9463	broad.mit.edu	37	22	38465038	38465038	+	Splice_Site	SNP	A	A	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr22:38465038A>G	ENST00000404072.3	+	6	696		c.e6-1		PICK1_ENST00000468288.1_Splice_Site|PICK1_ENST00000356976.3_Splice_Site|RP5-1039K5.13_ENST00000445483.1_RNA	NM_001039583.1|NM_001039584.1	NP_001034672.1|NP_001034673.1	Q9NRD5	PICK1_HUMAN	protein interacting with PRKCA 1						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|DNA methylation involved in embryo development|DNA methylation involved in gamete generation|monoamine transport|neuronal ion channel clustering|protein phosphorylation|receptor clustering|retrograde vesicle-mediated transport, Golgi to ER|synaptic transmission	cell junction|endocytic vesicle membrane|Golgi apparatus|perinuclear region of cytoplasm|presynaptic membrane	ATPase activity|metal ion binding|protein C-terminus binding|protein kinase C binding|receptor binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13	Melanoma(58;0.045)					TCCCCCGCTCAGTGTTGAAGA	0.627000													3	7					0	0	1	0	0
GABRP	2568	broad.mit.edu	37	5	170216203	170216203	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:170216203G>C	ENST00000518525.1	+	4	588	c.124G>C	c.(124-126)Gag>Cag	p.E42Q	GABRP_ENST00000265294.4_Missense_Mutation_p.E42Q|GABRP_ENST00000519385.1_Missense_Mutation_p.E42Q|GABRP_ENST00000519598.1_Missense_Mutation_p.E42Q			O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	42						cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(5)|large_intestine(4)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	29	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GCCTGGCTTTGAGAACCTCAC	0.483000													5	23					0	0	1	0	0
EPC1	80314	broad.mit.edu	37	10	32573890	32573890	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr10:32573890C>A	ENST00000319778.6	-	10	1782	c.1480G>T	c.(1480-1482)Gtc>Ttc	p.V494F	EPC1_ENST00000263062.8_Missense_Mutation_p.V494F|EPC1_ENST00000375110.2_Missense_Mutation_p.V444F	NM_001272004.1|NM_001272019.2	NP_001258933.1|NP_001258948.1	Q9H2F5	EPC1_HUMAN	enhancer of polycomb homolog 1 (Drosophila)	494					histone H2A acetylation|histone H4 acetylation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear membrane|Piccolo NuA4 histone acetyltransferase complex				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(8)|ovary(5)|urinary_tract(1)	24		Prostate(175;0.0199)				AACTGATTGACTGGAGAATGT	0.393000													6	88					0.0215528	0.0229339	1	1	0
SNORA76C	677842	broad.mit.edu	37	17	62223730	62223730	+	RNA	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:62223730C>T	ENST00000408535.2	+	0	32					NR_002995.1																						CGAGCTTCCTCGTGGCGCCGG	0.632000													7	87					0	0	1	0	0
DVL2	1856	broad.mit.edu	37	17	7130413	7130413	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:7130413C>T	ENST00000005340.5	-	13	1821	c.1539G>A	c.(1537-1539)gaG>gaA	p.E513E	DVL2_ENST00000575458.1_Silent_p.E507E	NM_004422.2	NP_004413.1	O14641	DVL2_HUMAN	dishevelled segment polarity protein 2	513					canonical Wnt receptor signaling pathway involved in regulation of cell proliferation|intracellular signal transduction|neural tube closure|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|segment specification|transcription from RNA polymerase II promoter	cytosol|nucleus|plasma membrane	frizzled binding|identical protein binding|signal transducer activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(7)|skin(1)	25						ACTTACAGCTCTCACAGCCAC	0.582000													5	50					0	0	1	0	0
TMEM116	89894	broad.mit.edu	37	12	112374514	112374514	+	Silent	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:112374514G>A	ENST00000354825.3	-	10	949	c.294C>T	c.(292-294)ctC>ctT	p.L98L	TMEM116_ENST00000550831.3_Silent_p.L98L|TMEM116_ENST00000355445.3_Silent_p.L155L|TMEM116_ENST00000437003.2_Silent_p.L98L|TMEM116_ENST00000549537.2_Intron|TMEM116_ENST00000552374.2_Silent_p.L190L			Q8NCL8	TM116_HUMAN	transmembrane protein 116	98						integral to membrane				endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|skin(1)	8						TAAGGAGGCTGAGTACAAAGC	0.483000													4	38					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179516232	179516232	+	Missense_Mutation	SNP	T	T	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:179516232T>A	ENST00000589042.1	-	207	39719	c.39495A>T	c.(39493-39495)gaA>gaT	p.E13165D	TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E11658D|TTN_ENST00000342992.6_Missense_Mutation_p.E10731D|TTN-AS1_ENST00000592630.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11518	Ig-like 87.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCACCTTCTTTTCAGGAACAA	0.478000													8	26					0	0	1	0	0
CTDSP1	58190	broad.mit.edu	37	2	219268015	219268015	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:219268015C>T	ENST00000273062.2	+	6	868	c.532C>T	c.(532-534)Cga>Tga	p.R178*	CTDSP1_ENST00000488627.1_3'UTR|CTDSP1_ENST00000443891.1_Nonsense_Mutation_p.R177*	NM_021198.2|NM_182642.2	NP_067021.1|NP_872580.1	Q9GZU7	CTDS1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1	178	FCP1 homology.				protein dephosphorylation|regulation of transcription from RNA polymerase II promoter	nucleus	CTD phosphatase activity|metal ion binding|protein binding			NS(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	8		Renal(207;0.0915)		Epithelial(149;9.96e-07)|all cancers(144;0.00017)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCGGCTGTTTCGAGAGTCCTG	0.647000													8	30					0	0	1	0	0
PLA2G12B	84647	broad.mit.edu	37	10	74701084	74701084	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr10:74701084C>A	ENST00000373032.3	-	3	401	c.309G>T	c.(307-309)ttG>ttT	p.L103F		NM_032562.2	NP_115951.2	Q9BX93	PG12B_HUMAN	phospholipase A2, group XIIB	103					lipid catabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(2)|skin(2)	9	Prostate(51;0.0198)					CTGGAATGCCCAAGTCCATCT	0.468000													12	87					6.40141e-05	7.78283e-05	1	1	0
SEPHS2	22928	broad.mit.edu	37	16	30455767	30455767	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr16:30455767G>A	ENST00000478753.2	-	1	1735	c.1282C>T	c.(1282-1284)Cgt>Tgt	p.R428C	SEPHS2_ENST00000542752.1_Missense_Mutation_p.R371C|SEPHS2_ENST00000500504.2_Missense_Mutation_p.R428C			Q99611	SPS2_HUMAN	selenophosphate synthetase 2	428					selenocysteine biosynthetic process		ATP binding|selenide, water dikinase activity			breast(3)|cervix(1)|kidney(1)|large_intestine(3)|lung(1)|upper_aerodigestive_tract(1)	10						GTGGCCCCACGAGGCAGGACT	0.537000													5	34					0	0	1	0	0
TMEM200C	645369	broad.mit.edu	37	18	5890256	5890256	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr18:5890256T>C	ENST00000581347.2	-	3	2452	c.1807A>G	c.(1807-1809)Atg>Gtg	p.M603V	RP11-945C19.4_ENST00000577694.1_RNA|TMEM200C_ENST00000383490.2_Missense_Mutation_p.M603V			A6NKL6	T200C_HUMAN	transmembrane protein 200C							integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(4)|lung(5)|stomach(1)	12						CTGGAAATCATGATGAGTTTC	0.557000													3	40					0	0	1	0	0
PPIP5K2	23262	broad.mit.edu	37	5	102482250	102482250	+	Silent	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:102482250G>A	ENST00000321521.9	+	6	1080	c.507G>A	c.(505-507)ggG>ggA	p.G169G	PPIP5K2_ENST00000414217.1_Silent_p.G169G|PPIP5K2_ENST00000513500.1_3'UTR|PPIP5K2_ENST00000358359.3_Silent_p.G169G			O43314	VIP2_HUMAN	diphosphoinositol pentakisphosphate kinase 2	169					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						TGATTGAAGGGGAAGATCATG	0.323000													6	51					0	0	1	0	0
TGM3	7053	broad.mit.edu	37	20	2291683	2291683	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr20:2291683G>A	ENST00000381458.5	+	4	511	c.448G>A	c.(448-450)Gct>Act	p.A150T		NM_003245.3	NP_003236.3	Q08188	TGM3_HUMAN	transglutaminase 3	150					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(11)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	39					L-Glutamine(DB00130)	GGGTAACCACGCTGAGAGAGA	0.483000													20	78					0	0	1	0	0
RAB3GAP1	22930	broad.mit.edu	37	2	135890467	135890467	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:135890467C>T	ENST00000264158.8	+	14	1282	c.1239C>T	c.(1237-1239)ttC>ttT	p.F413F	RAB3GAP1_ENST00000487003.1_3'UTR|RAB3GAP1_ENST00000539493.1_Silent_p.F369F|RAB3GAP1_ENST00000442034.1_Silent_p.F413F	NM_012233.2	NP_036365.1	Q15042	RB3GP_HUMAN	RAB3 GTPase activating protein subunit 1 (catalytic)	413						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	32				BRCA - Breast invasive adenocarcinoma(221;0.117)		CCTTCAAGTTCTTATTCCCTG	0.299000													8	76					0	0	1	0	0
CTDNEP1	23399	broad.mit.edu	37	17	7150433	7150433	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:7150433C>A	ENST00000573600.1	-	4	659	c.238G>T	c.(238-240)Gtc>Ttc	p.V80F	CTDNEP1_ENST00000318988.6_Missense_Mutation_p.V80F|CTDNEP1_ENST00000572043.1_5'UTR|CTDNEP1_ENST00000574322.1_Missense_Mutation_p.V80F|RP1-4G17.5_ENST00000577138.1_3'UTR			O95476	CNEP1_HUMAN	CTD nuclear envelope phosphatase 1	80	FCP1 homology.				nuclear envelope organization|protein dephosphorylation	endoplasmic reticulum membrane|integral to membrane|nuclear membrane	protein serine/threonine phosphatase activity			central_nervous_system(9)|kidney(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	15						GGCCTCAGGACCCCATCATGG	0.547000													9	53					1.12685e-05	1.41642e-05	1	1	0
ZKSCAN5	23660	broad.mit.edu	37	7	99123464	99123464	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:99123464C>T	ENST00000394170.2	+	6	1052	c.801C>T	c.(799-801)ctC>ctT	p.L267L	ZKSCAN5_ENST00000451158.1_Silent_p.L267L|ZKSCAN5_ENST00000326775.5_Silent_p.L267L	NM_014569.3	NP_055384.1	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	267	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	21	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					ATATGGAGCTCATAGTGAAGC	0.428000													5	81					0	0	1	0	0
PCDHGA10	56106	broad.mit.edu	37	5	140794462	140794462	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:140794462G>T	ENST00000398610.2	+	1	1720	c.1720G>T	c.(1720-1722)Gac>Tac	p.D574Y	PCDHGA9_ENST00000573521.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGB3_ENST00000576222.1_Intron	NM_018913.2|NM_032090.1	NP_061736.1|NP_114479.1														breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTCCCCACAGACGGTTCCAC	0.662000													9	151					0.000673444	0.000776861	1	1	0
VWA3B	200403	broad.mit.edu	37	2	98736153	98736153	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:98736153G>C	ENST00000477737.1	+	4	673	c.469G>C	c.(469-471)Gat>Cat	p.D157H	VWA3B_ENST00000435344.1_Missense_Mutation_p.D157H|VWA3B_ENST00000451075.2_Intron	NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	157										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						GGGGGAGCTTGATCTGTGCCG	0.517000													20	116					0	0	1	0	0
SPECC1	92521	broad.mit.edu	37	17	20108964	20108964	+	Silent	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:20108964C>A	ENST00000395530.2	+	2	1567	c.1359C>A	c.(1357-1359)gcC>gcA	p.A453A	AC004702.2_ENST00000580225.1_lincRNA|SPECC1_ENST00000395522.2_Silent_p.A453A|SPECC1_ENST00000395529.3_Silent_p.A534A|SPECC1_ENST00000261503.5_Silent_p.A534A|SPECC1_ENST00000395527.4_Silent_p.A534A|SPECC1_ENST00000395525.3_Silent_p.A453A|SPECC1_ENST00000472876.1_Intron|SPECC1_ENST00000536879.1_Intron	NM_001033555.2	NP_001028727.1	Q5M775	CYTSB_HUMAN	sperm antigen with calponin homology and coiled-coil domains 1	534						nucleus				breast(1)|large_intestine(3)|ovary(4)	8				KIRC - Kidney renal clear cell carcinoma(2;0.166)|Kidney(2;0.196)		ACATGATGGCCAAAACTTTGG	0.388000													5	52					0.000602214	0.000695966	1	1	0
SLC25A11	8402	broad.mit.edu	37	17	4841113	4841113	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:4841113C>A	ENST00000225665.7	-	8	1208	c.868G>T	c.(868-870)Ggc>Tgc	p.G290C	SLC25A11_ENST00000544061.2_Missense_Mutation_p.G239C	NM_001165417.1|NM_003562.4	NP_001158889.1|NP_003553.2	Q02978	M2OM_HUMAN	solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11	290					gluconeogenesis	integral to plasma membrane|mitochondrial inner membrane	oxoglutarate:malate antiporter activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(5)	10						GTGTGGGGGCCCAGGCGGGCA	0.612000													5	36					0.014758	0.0160005	1	1	0
CIZ1	25792	broad.mit.edu	37	9	130931369	130931369	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr9:130931369C>T	ENST00000538431.1	-	15	2582	c.2335G>A	c.(2335-2337)Gaa>Aaa	p.E779K	CIZ1_ENST00000277465.4_Missense_Mutation_p.E725K|CIZ1_ENST00000541172.1_Missense_Mutation_p.E652K|CIZ1_ENST00000325721.8_Missense_Mutation_p.E724K|CIZ1_ENST00000372948.3_Missense_Mutation_p.E697K|CIZ1_ENST00000476727.2_5'UTR|CIZ1_ENST00000393608.1_Missense_Mutation_p.E753K|CIZ1_ENST00000372938.5_Missense_Mutation_p.E753K|CIZ1_ENST00000357558.5_Missense_Mutation_p.E725K|CIZ1_ENST00000372954.1_Missense_Mutation_p.E673K	NM_001257975.1	NP_001244904.1	Q9ULV3	CIZ1_HUMAN	CDKN1A interacting zinc finger protein 1	753						nucleus	nucleic acid binding|protein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|liver(1)|lung(9)|ovary(3)|prostate(2)|urinary_tract(2)	35						atctcttcttcatcctcatca	0.552000													13	63					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54542588	54542588	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr15:54542588G>A	ENST00000545554.1	+	7	3394	c.3394G>A	c.(3394-3396)Gga>Aga	p.G1132R	UNC13C_ENST00000537900.1_Missense_Mutation_p.G1130R|UNC13C_ENST00000260323.11_Missense_Mutation_p.G1132R			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1132					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TCTGGAGTGTGGAGTGAAATG	0.512000													8	39					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169157521	169157521	+	Nonsense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr4:169157521G>C	ENST00000393743.3	-	33	4706	c.4415C>G	c.(4414-4416)tCa>tGa	p.S1472*		NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	1472							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		AAAATGTTTTGAGCCTATATA	0.299000													7	27					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	141016298	141016298	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr9:141016298C>A	ENST00000277551.2	+	47	6825	c.6680C>A	c.(6679-6681)gCc>gAc	p.A2227D	CACNA1B_ENST00000371357.1_Silent_p.G2288G|CACNA1B_ENST00000371363.1_Silent_p.G2287G|CACNA1B_ENST00000277549.5_Silent_p.G1483G|CACNA1B_ENST00000371355.4_Silent_p.G2290G|CACNA1B_ENST00000371372.1_Silent_p.G2289G			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	0					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CCAACTCGGGCCGCTCCTCCA	0.652000													5	39					0.000602214	0.000695966	1	1	0
IGHA1	3493	broad.mit.edu	37	14	106173485	106173485	+	RNA	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr14:106173485G>T	ENST00000390547.2	-	0	1081																											TTTATTCAGGGGTGGGGACAG	0.622000													3	27					1	1	1	1	0
RGPD8	727851	broad.mit.edu	37	2	113127775	113127775	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:113127775G>C	ENST00000302558.3	-	23	5469	c.5278C>G	c.(5278-5280)Cct>Gct	p.P1760A	RGPD8_ENST00000409750.1_Missense_Mutation_p.P1620A	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8									p.P1760A(12)		endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						GAACGGGAAGGATTTTCTTCC	0.308000													3	25					0	0	1	0	0
WDR53	348793	broad.mit.edu	37	3	196281336	196281336	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:196281336C>G	ENST00000332629.5	-	4	1390	c.823G>C	c.(823-825)Gag>Cag	p.E275Q	WDR53_ENST00000433160.1_Missense_Mutation_p.E116Q|WDR53_ENST00000429115.1_Missense_Mutation_p.E114Q	NM_182627.1	NP_872433.1	Q7Z5U6	WDR53_HUMAN	WD repeat domain 53	275										breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)	13	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.6e-23)|all cancers(36;1.54e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.29e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		TGTTTTTTCTCAACTTCACTG	0.458000													4	71					0	0	1	0	0
GBP4	115361	broad.mit.edu	37	1	89654401	89654401	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:89654401A>G	ENST00000355754.6	-	8	1371	c.1274T>C	c.(1273-1275)cTt>cCt	p.L425P		NM_052941.4	NP_443173.2	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	425						cytoplasm	GTP binding|GTPase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(19)|skin(1)|stomach(2)|urinary_tract(1)	33				all cancers(265;0.00723)|Epithelial(280;0.0291)		AAGCCGCTTAAGCTCAGCCTG	0.433000													18	164					0	0	1	0	0
TUBD1	51174	broad.mit.edu	37	17	57952060	57952060	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:57952060G>T	ENST00000325752.3	-	6	1051	c.774C>A	c.(772-774)gaC>gaA	p.D258E	TUBD1_ENST00000592426.1_Missense_Mutation_p.D258E|TUBD1_ENST00000340993.6_Intron|TUBD1_ENST00000376094.4_Intron|TUBD1_ENST00000394239.3_Missense_Mutation_p.D258E|TUBD1_ENST00000346141.6_Intron|TUBD1_ENST00000539018.1_Missense_Mutation_p.D42E	NM_016261.3	NP_057345.2	Q9UJT1	TBD_HUMAN	tubulin, delta 1	258					cell differentiation|microtubule-based movement|multicellular organismal development|protein polymerization|spermatogenesis	centriole|microtubule|nucleus	GTP binding|GTPase activity|structural molecule activity			NS(2)|breast(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|skin(1)|stomach(2)	21	all_cancers(5;3.18e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;9.34e-13)|all cancers(12;1.91e-11)			GCTCCATTAAGTCTCCTGTAA	0.338000													14	80					7.93312e-07	1.03212e-06	1	1	0
DLGAP4	22839	broad.mit.edu	37	20	35060760	35060760	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr20:35060760G>A	ENST00000373913.3	+	3	1120	c.640G>A	c.(640-642)Gag>Aag	p.E214K	DLGAP4_ENST00000339266.5_Missense_Mutation_p.E214K|DLGAP4_ENST00000373907.2_Missense_Mutation_p.E214K|DLGAP4_ENST00000401952.2_Missense_Mutation_p.E214K			Q9Y2H0	DLGP4_HUMAN	discs, large (Drosophila) homolog-associated protein 4	214					cell-cell signaling	membrane	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(20)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CTTGGACGGCGAGGCCGGCGC	0.657000													5	39					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129900873	129900873	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr10:129900873G>C	ENST00000368654.3	-	13	9606	c.9231C>G	c.(9229-9231)caC>caG	p.H3077Q	MKI67_ENST00000368653.3_Missense_Mutation_p.H2717Q	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	3077					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CTTGTAATTTGTGTTCCTCTT	0.408000													12	159					0	0	1	0	0
BAZ2B	29994	broad.mit.edu	37	2	160294826	160294826	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:160294826C>A	ENST00000392783.2	-	8	1776	c.1281G>T	c.(1279-1281)ttG>ttT	p.L427F	BAZ2B_ENST00000355831.2_Missense_Mutation_p.L427F|BAZ2B_ENST00000392782.1_Missense_Mutation_p.L425F|BAZ2B_ENST00000343439.5_Missense_Mutation_p.L425F	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	427					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						GTTTGGATCTCAATTCACTGG	0.303000													3	40					0.115264	0.120019	1	1	0
BAZ2B	29994	broad.mit.edu	37	2	160194240	160194240	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:160194240A>G	ENST00000392783.2	-	32	5993	c.5498T>C	c.(5497-5499)gTa>gCa	p.V1833A	BAZ2B_ENST00000355831.2_Missense_Mutation_p.V1799A|BAZ2B_ENST00000392782.1_Missense_Mutation_p.V1797A|BAZ2B_ENST00000343439.5_Missense_Mutation_p.V1733A	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1833					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						TTCAAAATATACCAAGTCCTC	0.403000													5	37					0	0	1	0	0
PML	5371	broad.mit.edu	37	15	74315653	74315653	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr15:74315653G>A	ENST00000565898.1	+	3	1171	c.1087G>A	c.(1087-1089)Gag>Aag	p.E363K	PML_ENST00000268058.3_Missense_Mutation_p.E363K|PML_ENST00000569477.1_Missense_Mutation_p.E363K|PML_ENST00000435786.2_Missense_Mutation_p.E363K|PML_ENST00000436891.3_Missense_Mutation_p.E363K|PML_ENST00000268059.6_Missense_Mutation_p.E363K|PML_ENST00000567543.1_Missense_Mutation_p.E363K|PML_ENST00000569161.1_3'UTR|PML_ENST00000569965.1_Missense_Mutation_p.E363K|PML_ENST00000395132.2_Missense_Mutation_p.E363K|PML_ENST00000354026.6_Missense_Mutation_p.E363K|PML_ENST00000563500.1_Missense_Mutation_p.E363K|PML_ENST00000359928.4_Missense_Mutation_p.E363K|PML_ENST00000564428.1_Missense_Mutation_p.E363K|PML_ENST00000395135.3_Missense_Mutation_p.E363K			P29590	PML_HUMAN	promyelocytic leukemia	363					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding	p.E363K(3)		breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	31						GCGCCAGGAGGAGCCCCAGAG	0.652000			T	"""RARA, PAX5"""	"""APL, ALL"""								3	36					0	0	1	0	0
RALGAPB	57148	broad.mit.edu	37	20	37150306	37150306	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr20:37150306G>C	ENST00000262879.6	+	10	1868	c.1584G>C	c.(1582-1584)aaG>aaC	p.K528N	RALGAPB_ENST00000397042.3_Missense_Mutation_p.K528N|RALGAPB_ENST00000537204.1_Intron|RALGAPB_ENST00000397040.1_Missense_Mutation_p.K528N|RALGAPB_ENST00000397038.1_Missense_Mutation_p.K306N			Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit (non-catalytic)	528					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(29)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						GTAGCAAGAAGACTGGAGAAG	0.378000													5	97					0	0	1	0	0
OPHN1	4983	broad.mit.edu	37	X	67273548	67273548	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:67273548G>C	ENST00000355520.5	-	22	2904	c.2263C>G	c.(2263-2265)Caa>Gaa	p.Q755E	OPHN1_ENST00000540071.1_Missense_Mutation_p.Q647E	NM_002547.2	NP_002538.1	O60890	OPHN1_HUMAN	oligophrenin 1	755	Pro-rich.				axon guidance|endocytosis|filopodium assembly|small GTPase mediated signal transduction|substrate-dependent cell migration, cell extension	axon|cell junction|cytosol|dendritic spine|synapse	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|skin(2)	31						TCTGGCTTTTGGGGAGTAGCT	0.547000													7	22					0	0	1	0	0
DEPDC1	55635	broad.mit.edu	37	1	68948511	68948511	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:68948511G>T	ENST00000456315.2	-	8	1094	c.980C>A	c.(979-981)tCt>tAt	p.S327Y	RP4-694A7.2_ENST00000425820.1_RNA|DEPDC1_ENST00000370966.5_Intron	NM_001114120.1	NP_001107592.1	Q5TB30	DEP1A_HUMAN	DEP domain containing 1	327					intracellular signal transduction|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(397;7.21e-36)		GAATTTTGAAGACTGTGGATC	0.343000													5	48					3.59834e-05	4.42602e-05	1	1	0
MUSK	4593	broad.mit.edu	37	9	113547941	113547941	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr9:113547941A>G	ENST00000416899.2	+	11	1823	c.1697A>G	c.(1696-1698)aAc>aGc	p.N566S	MUSK_ENST00000189978.5_Missense_Mutation_p.N574S|MUSK_ENST00000374448.4_Missense_Mutation_p.N574S|MUSK_ENST00000374438.1_Missense_Mutation_p.N90S			O15146	MUSK_HUMAN	muscle, skeletal, receptor tyrosine kinase	574					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(23)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	49						CCAAGGAATAACATTGAATAT	0.433000													4	75					0	0	1	0	0
PRKACA	5566	broad.mit.edu	37	19	14208663	14208663	+	Silent	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:14208663C>A	ENST00000308677.4	-	6	655	c.459G>T	c.(457-459)ctG>ctT	p.L153L	PRKACA_ENST00000589994.1_Silent_p.L145L|PRKACA_ENST00000590853.1_Intron|PRKACA_ENST00000350356.3_5'UTR	NM_002730.3	NP_002721.1	P17612	KAPCA_HUMAN	protein kinase, cAMP-dependent, catalytic, alpha	153	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|regulation of insulin secretion|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|cAMP-dependent protein kinase inhibitor activity|protein kinase binding			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)	16						ACTCAAAGGTCAGGACGATCT	0.572000													4	36					0.217242	0.22074	1	1	0
PLSCR1	5359	broad.mit.edu	37	3	146251317	146251317	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:146251317G>T	ENST00000342435.4	-	3	444	c.34C>A	c.(34-36)Cac>Aac	p.H12N	PLSCR1_ENST00000448205.1_5'UTR|PLSCR1_ENST00000487389.1_Missense_Mutation_p.H5N|PLSCR1_ENST00000448787.2_Silent_p.L3L	NM_021105.2	NP_066928.1	O15162	PLS1_HUMAN	phospholipid scramblase 1	12					phospholipid scrambling|platelet activation|response to virus	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)	15						GTTTCCGGGTGAGAAGCATTC	0.353000													6	54					0.00116845	0.00133567	1	1	0
ZBTB22	9278	broad.mit.edu	37	6	33282940	33282940	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr6:33282940G>A	ENST00000431845.2	-	2	1905	c.1754C>T	c.(1753-1755)tCc>tTc	p.S585F	ZBTB22_ENST00000418724.1_Missense_Mutation_p.S585F	NM_005453.4	NP_005444.4	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	585					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(3)	21						GGACGGCAAGGATGGCCCCGT	0.726000													4	28					0	0	1	0	0
ADGRG1	9289	broad.mit.edu	37	16	57695753	57695753	+	Silent	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr16:57695753G>T	ENST00000562631.1	+	13	2341	c.1809G>T	c.(1807-1809)gtG>gtT	p.V603V	GPR56_ENST00000568909.1_Silent_p.V609V|GPR56_ENST00000456916.1_Silent_p.V609V|GPR56_ENST00000567835.1_Silent_p.V609V|GPR56_ENST00000388813.5_Silent_p.V603V|GPR56_ENST00000544297.1_Silent_p.V428V|GPR56_ENST00000562558.1_Silent_p.V603V|GPR56_ENST00000379694.4_Silent_p.V439V|GPR56_ENST00000538815.1_Silent_p.V603V|GPR56_ENST00000568908.1_Silent_p.V603V|GPR56_ENST00000388812.4_Silent_p.V609V|GPR56_ENST00000379696.3_Silent_p.V609V|GPR56_ENST00000540164.2_Silent_p.V603V			Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56	609					brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity			kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)	15						GGTCACATGTGCTGACACTGC	0.582000													4	34					0.150653	0.155077	1	1	0
GET4	51608	broad.mit.edu	37	7	927057	927057	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:927057G>A	ENST00000407192.1	+	3	2725	c.208G>A	c.(208-210)Gtg>Atg	p.V70M	GET4_ENST00000265857.3_Missense_Mutation_p.V123M			Q7L5D6	GET4_HUMAN	golgi to ER traffic protein 4 homolog (S. cerevisiae)	123					tail-anchored membrane protein insertion into ER membrane|transport	BAT3 complex	protein binding			breast(1)|large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						TCCTGAGCGCGTGACCTTTGT	0.622000													17	56					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40398419	40398419	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:40398419G>A	ENST00000221347.6	-	14	6555	c.6548C>T	c.(6547-6549)tCa>tTa	p.S2183L		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	2183	VWFD 5.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CGAGAGCCCTGAGGTTGTGGT	0.667000													4	47					0	0	1	0	0
HECTD1	25831	broad.mit.edu	37	14	31576793	31576793	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr14:31576793G>A	ENST00000399332.1	-	37	7086	c.6598C>T	c.(6598-6600)Cca>Tca	p.P2200S	HECTD1_ENST00000553700.1_Missense_Mutation_p.P2200S	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	2200	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		TCATCATCTGGAAAATTATCA	0.403000													4	40					0	0	1	0	0
ZNF773	374928	broad.mit.edu	37	19	58017833	58017833	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:58017833C>A	ENST00000282292.4	+	4	510	c.370C>A	c.(370-372)Ccc>Acc	p.P124T	ZNF773_ENST00000598770.1_Missense_Mutation_p.P123T|ZNF773_ENST00000599847.1_Intron|ZNF773_ENST00000593916.1_Intron	NM_198542.1	NP_940944.1	Q6PK81	ZN773_HUMAN	zinc finger protein 773	124					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0254)		TGGAGAGAAACCCTTAAAAAG	0.517000													9	28					1.12685e-05	1.41642e-05	1	1	0
FCRL2	79368	broad.mit.edu	37	1	157739773	157739773	+	Missense_Mutation	SNP	G	G	A	rs148305794	byFrequency	TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:157739773G>A	ENST00000361516.3	-	4	526	c.478C>T	c.(478-480)Ccg>Tcg	p.P160S	FCRL2_ENST00000392274.3_Missense_Mutation_p.P160S|FCRL2_ENST00000368181.4_Intron	NM_030764.3	NP_110391.2	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2	160	Ig-like C2-type 2.				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|skin(2)	51	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TGGAGCTCCGGAGAGCTGCTC	0.537000													6	44					0	0	1	0	0
SNAPC1	6617	broad.mit.edu	37	14	62229256	62229256	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr14:62229256C>T	ENST00000216294.4	+	1	182	c.78C>T	c.(76-78)ttC>ttT	p.F26F	RP11-618G20.1_ENST00000555937.1_RNA	NM_003082.3	NP_003073.1	Q16533	SNPC1_HUMAN	small nuclear RNA activating complex, polypeptide 1, 43kDa	26	SNAPC3-binding.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)	13				OV - Ovarian serous cystadenocarcinoma(108;0.0639)|BRCA - Breast invasive adenocarcinoma(234;0.186)		GTGTACGCTTCGAGGACTTCA	0.632000													6	60					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39266035	39266035	+	Silent	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr13:39266035C>G	ENST00000280481.7	+	1	4770	c.4554C>G	c.(4552-4554)gtC>gtG	p.V1518V		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	1518					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GTAACCCTGTCTTTCGGACAT	0.433000													6	90					0	0	1	0	0
OR4C16	219428	broad.mit.edu	37	11	55339669	55339669	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:55339669G>C	ENST00000314634.3	+	1	66	c.66G>C	c.(64-66)aaG>aaC	p.K22N		NM_001004701.2	NP_001004701.2	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene)	22					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(28)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41		all_epithelial(135;0.0748)				CTTTTTGGAAGAAAATAGTGT	0.398000													5	55					0	0	1	0	0
LRRC3B	116135	broad.mit.edu	37	3	26751267	26751267	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:26751267C>A	ENST00000396641.2	+	2	696	c.104C>A	c.(103-105)cCc>cAc	p.P35H	LRRC3B_ENST00000456208.2_Missense_Mutation_p.P35H|LRRC3B_ENST00000417744.1_Missense_Mutation_p.P35H	NM_052953.2	NP_443185.1	Q96PB8	LRC3B_HUMAN	leucine rich repeat containing 3B	35	LRRNT.					integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|skin(4)	21						AGTATGTGTCCCAAGGGCTGT	0.438000													4	43					1	1	1	1	0
NXF5	55998	broad.mit.edu	37	X	101091708	101091708	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:101091708G>T	ENST00000361708.2	-	16	1537	c.1178C>A	c.(1177-1179)cCa>cAa	p.P393Q	NXF5_ENST00000473265.2_Intron|NXF5_ENST00000537026.1_Intron			Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5	393					mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|skin(1)	30						GCACTAACCTGGAATTGCGGC	0.522000													4	62					1.23904e-05	1.53602e-05	1	1	0
ZDHHC9	51114	broad.mit.edu	37	X	128946732	128946732	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:128946732T>C	ENST00000357166.6	-	8	1130	c.739A>G	c.(739-741)Act>Gct	p.T247A	ZDHHC9_ENST00000371064.3_Missense_Mutation_p.T247A	NM_016032.3	NP_057116.2	Q9Y397	ZDHC9_HUMAN	zinc finger, DHHC-type containing 9	247						endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acyltransferase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)	19						ACGAGGAAAGTATGAAATCCA	0.448000													17	85					0	0	1	0	0
GNG3	2785	broad.mit.edu	37	11	62476275	62476275	+	Silent	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:62476275C>G	ENST00000294117.5	+	3	484	c.225C>G	c.(223-225)ctC>ctG	p.L75L	HNRNPUL2-BSCL2_ENST00000403734.2_Intron|BSCL2_ENST00000405837.1_Intron|BSCL2_ENST00000433053.1_Intron	NM_012202.4	NP_036334.1	P63215	GBG3_HUMAN	guanine nucleotide binding protein (G protein), gamma 3	75					activation of MAPK activity|cellular response to glucagon stimulus|energy reserve metabolic process|synaptic transmission		GTPase activity|signal transducer activity			kidney(1)|large_intestine(1)|lung(2)|urinary_tract(1)	5						GTGCTCTCCTCTGAGCTCCCC	0.567000													8	60					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113585870	113585870	+	Missense_Mutation	SNP	T	T	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr8:113585870T>A	ENST00000297405.5	-	24	4146	c.3902A>T	c.(3901-3903)gAt>gTt	p.D1301V	CSMD3_ENST00000455883.2_Missense_Mutation_p.D1197V|CSMD3_ENST00000343508.3_Missense_Mutation_p.D1261V|CSMD3_ENST00000352409.3_Missense_Mutation_p.D1301V	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1301	CUB 7.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AGTCGTTTTATCTTTTCCATC	0.313000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			5	43					0	0	1	0	0
MED24	9862	broad.mit.edu	37	17	38209884	38209884	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:38209884G>T	ENST00000394126.1	-	1	461	c.43C>A	c.(43-45)Ccg>Acg	p.P15T	MED24_ENST00000394127.2_5'UTR|MED24_ENST00000479829.1_5'UTR|MED24_ENST00000356271.3_5'UTR|MED24_ENST00000394128.2_5'UTR			O75448	MED24_HUMAN	mediator complex subunit 24	0					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			autonomic_ganglia(1)|breast(2)|endometrium(9)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	41	Colorectal(19;0.000442)					AGCGGTGGCGGCCAGCTTTGA	0.493000													9	51					1.12685e-05	1.41642e-05	1	1	0
PSAT1	29968	broad.mit.edu	37	9	80943903	80943903	+	Silent	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr9:80943903G>T	ENST00000376588.3	+	9	1082	c.1014G>T	c.(1012-1014)gtG>gtT	p.V338V	PSAT1_ENST00000347159.2_Silent_p.V292V	NM_058179.2	NP_478059.1	Q9Y617	SERC_HUMAN	phosphoserine aminotransferase 1	338					L-serine biosynthetic process|pyridoxine biosynthetic process		O-phospho-L-serine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding	p.V338V(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|urinary_tract(1)	20					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)	CTAGGTCTGTGGGAGGCATCC	0.453000													4	57					0.00024832	0.000293427	1	1	0
FIG4	9896	broad.mit.edu	37	6	110053865	110053865	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr6:110053865G>T	ENST00000230124.3	+	5	596	c.472G>T	c.(472-474)Gac>Tac	p.D158Y	FIG4_ENST00000441478.2_Missense_Mutation_p.D12Y|FIG4_ENST00000368941.1_Missense_Mutation_p.D81Y	NM_014845.5	NP_055660.1	Q92562	FIG4_HUMAN	FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)	158	SAC.				cell death	endosome membrane	protein binding			central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)	32		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		TCAAAATGTGGACCTATCTAG	0.294000													5	34					3.59834e-05	4.42602e-05	1	1	0
ZAK	51776	broad.mit.edu	37	2	174062798	174062798	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:174062798G>T	ENST00000338983.3	+	8	822	c.627G>T	c.(625-627)ttG>ttT	p.L209F	MLTK_ENST00000431503.2_Missense_Mutation_p.L108F|MLTK_ENST00000539448.1_Missense_Mutation_p.L209F|MLTK_ENST00000375213.3_Missense_Mutation_p.L209F|MLK7-AS1_ENST00000422703.1_RNA|MLK7-AS1_ENST00000419609.1_RNA|MLK7-AS1_ENST00000423106.2_RNA|MLTK_ENST00000409176.2_Missense_Mutation_p.L209F	NM_133646.2	NP_598407.1																					TTAAAGGTTTGGAAGGATTAC	0.368000													15	59					0.146539	0.152333	1	1	0
SPRYD3	84926	broad.mit.edu	37	12	53471027	53471027	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:53471027C>T	ENST00000301463.4	-	2	128	c.42G>A	c.(40-42)aaG>aaA	p.K14K	SPRYD3_ENST00000547837.1_Silent_p.K51K	NM_032840.2	NP_116229.1	Q8NCJ5	SPRY3_HUMAN	SPRY domain containing 3	14										central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	17						GGTCATCCATCTTGTTCATGA	0.537000													3	35					0	0	1	0	0
CFAP221	200373	broad.mit.edu	37	2	120413966	120413966	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:120413966G>C	ENST00000602047.1	+	25	2697	c.1585G>C	c.(1585-1587)Gag>Cag	p.E529Q	PCDP1_ENST00000413369.3_Missense_Mutation_p.E815Q			Q4G0U5	PCDP1_HUMAN		815						cilium	calmodulin binding					Colorectal(110;0.196)					ACAACCAGCAGAGAAGGCCGG	0.488000													4	16					0	0	1	0	0
NTNG1	22854	broad.mit.edu	37	1	107867484	107867484	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:107867484T>C	ENST00000370067.1	+	3	1454	c.827T>C	c.(826-828)gTa>gCa	p.V276A	NTNG1_ENST00000370068.1_Missense_Mutation_p.V276A|NTNG1_ENST00000370070.2_Missense_Mutation_p.V276A|NTNG1_ENST00000370066.1_Missense_Mutation_p.V276A|NTNG1_ENST00000370071.2_Missense_Mutation_p.V276A|NTNG1_ENST00000370072.3_Missense_Mutation_p.V276A|NTNG1_ENST00000370061.3_Missense_Mutation_p.V276A|NTNG1_ENST00000477948.1_3'UTR|NTNG1_ENST00000370065.1_Missense_Mutation_p.V276A|NTNG1_ENST00000370073.2_Missense_Mutation_p.V276A|NTNG1_ENST00000370074.4_Missense_Mutation_p.V276A|NTNG1_ENST00000542803.1_Missense_Mutation_p.V276A			Q9Y2I2	NTNG1_HUMAN	netrin G1	276	Laminin N-terminal.				axonogenesis	anchored to plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|soft_tissue(1)|urinary_tract(1)	37		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		GAAATATTTGTAGATGAGCTA	0.463000													12	51					0	0	1	0	0
HAO1	54363	broad.mit.edu	37	20	7886851	7886851	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr20:7886851C>A	ENST00000378789.3	-	4	722	c.671G>T	c.(670-672)tGg>tTg	p.W224L		NM_017545.2	NP_060015.1	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase (glycolate oxidase) 1	224	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						TCTTCTCAGCCATTTGATATC	0.398000													16	107					1.15919e-05	1.45128e-05	1	1	0
CYB5D1	124637	broad.mit.edu	37	17	7762002	7762002	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:7762002C>T	ENST00000332439.4	+	3	468	c.316C>T	c.(316-318)Cag>Tag	p.Q106*	LSMD1_ENST00000570555.1_5'UTR|LSMD1_ENST00000576861.1_Intron|CYB5D1_ENST00000571846.1_Nonsense_Mutation_p.Q106*|CYB5D1_ENST00000570446.1_Intron	NM_144607.4	NP_653208.2	Q6P9G0	CB5D1_HUMAN	cytochrome b5 domain containing 1	106							heme binding	p.Q106*(1)		breast(1)|endometrium(1)|large_intestine(2)|skin(2)	6		all_cancers(10;0.11)|Prostate(122;0.219)				CGTTCCGCCTCAGCTGCCCTG	0.632000											OREG0024147	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	45					0	0	1	0	0
HIST2H2BE	8349	broad.mit.edu	37	1	149857969	149857969	+	Silent	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:149857969G>A	ENST00000369155.2	-	1	263	c.222C>T	c.(220-222)atC>atT	p.I74I		NM_003528.2	NP_003519.1	Q16778	H2B2E_HUMAN	histone cluster 2, H2be	74					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	14	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			CCTCTCCCGCGATGCGCTCGA	0.637000													6	129					0	0	1	0	0
CCKAR	886	broad.mit.edu	37	4	26483765	26483765	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr4:26483765C>T	ENST00000295589.3	-	5	976	c.782G>A	c.(781-783)gGc>gAc	p.G261D		NM_000730.2	NP_000721.1	P32238	CCKAR_HUMAN	cholecystokinin A receptor	261					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			NS(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|pancreas(1)|skin(1)	29		Breast(46;0.0503)			Ceruletide(DB00403)	CTCATATTTGCCGCTGCTGGT	0.612000													3	53					0	0	1	0	0
OR5AK2	390181	broad.mit.edu	37	11	56756999	56756999	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:56756999G>T	ENST00000326855.2	+	1	653	c.611G>T	c.(610-612)gGa>gTa	p.G204V		NM_001005323.1	NP_001005323.1	Q8NH90	O5AK2_HUMAN	olfactory receptor, family 5, subfamily AK, member 2	204					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	21						GTCTTTGTGGGATCTAACTTG	0.408000													31	96					1.39806e-14	1.96038e-14	1	1	0
SLC24A5	283652	broad.mit.edu	37	15	48426535	48426535	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr15:48426535C>T	ENST00000341459.3	+	3	455	c.382C>T	c.(382-384)Cta>Tta	p.L128L	SLC24A5_ENST00000449382.2_Silent_p.L68L	NM_205850.2	NP_995322.1	Q71RS6	NCKX5_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 5	128					response to stimulus	integral to membrane|melanosome|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity	p.L128L(1)		cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|skin(1)|upper_aerodigestive_tract(1)	27		all_lung(180;0.00217)		all cancers(107;3.29e-10)|GBM - Glioblastoma multiforme(94;7.32e-07)		TACTGCTTTCCTAGGTAAATA	0.393000													3	67					0	0	1	0	0
CCDC3	83643	broad.mit.edu	37	10	13040395	13040395	+	Silent	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr10:13040395C>A	ENST00000378839.1	-	6	1069	c.117G>T	c.(115-117)tcG>tcT	p.S39S	CCDC3_ENST00000378825.3_Silent_p.S164S	NM_001282658.1	NP_001269587.1	Q9BQI4	CCDC3_HUMAN	coiled-coil domain containing 3	164						endoplasmic reticulum|extracellular region				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)|prostate(2)	11		Ovarian(717;0.0822)	BRCA - Breast invasive adenocarcinoma(52;0.163)			GCTGCCCTTGCGAACAGTTTG	0.463000													8	53					1.12685e-05	1.41642e-05	1	1	0
GHSR	2693	broad.mit.edu	37	3	172165995	172165995	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:172165995C>A	ENST00000241256.2	-	1	251	c.209G>T	c.(208-210)cGc>cTc	p.R70L	GHSR_ENST00000427970.1_Missense_Mutation_p.R70L	NM_198407.2	NP_940799.1	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor	70					actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	33	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			CTCGCGGAAGCGCGACACCAC	0.657000													5	28					1.23904e-05	1.53602e-05	1	1	0
DNAJC6	9829	broad.mit.edu	37	1	65874363	65874363	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:65874363C>G	ENST00000395325.3	+	17	2517	c.2360C>G	c.(2359-2361)tCt>tGt	p.S787C	DNAJC6_ENST00000263441.7_Missense_Mutation_p.S774C|DNAJC6_ENST00000371069.4_Missense_Mutation_p.S844C	NM_014787.3	NP_055602.1	O75061	AUXI_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 6	787					cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(22)|ovary(1)|prostate(2)|skin(1)	39						GACCTACTCTCTGGTCAAGGT	0.368000													6	74					0	0	1	0	0
PLCL1	5334	broad.mit.edu	37	2	198948823	198948823	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:198948823C>A	ENST00000428675.1	+	2	980	c.582C>A	c.(580-582)caC>caA	p.H194Q	PLCL1_ENST00000437704.2_Missense_Mutation_p.H96Q	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	194	Interaction with PPP1C.|PH.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	CCATACTCCACGGGGAAAACT	0.478000													13	55					1.61879e-10	2.23514e-10	1	1	0
STXBP6	29091	broad.mit.edu	37	14	25443936	25443936	+	Missense_Mutation	SNP	T	T	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr14:25443936T>A	ENST00000323944.5	-	2	540	c.89A>T	c.(88-90)aAg>aTg	p.K30M	STXBP6_ENST00000358326.2_Missense_Mutation_p.K30M|STXBP6_ENST00000548724.1_Missense_Mutation_p.K30M|STXBP6_ENST00000419632.2_Missense_Mutation_p.K30M|STXBP6_ENST00000550887.1_Missense_Mutation_p.K30M|STXBP6_ENST00000396700.1_Missense_Mutation_p.K30M|STXBP6_ENST00000546511.1_Missense_Mutation_p.K30M			Q8NFX7	STXB6_HUMAN	syntaxin binding protein 6 (amisyn)	30					vesicle-mediated transport	cytoplasm|integral to membrane				central_nervous_system(2)|endometrium(2)|large_intestine(3)	7				GBM - Glioblastoma multiforme(265;0.0296)		AATCTTTTTCTTTGTCCTCCT	0.378000													3	17					0	0	1	0	0
LMLN	89782	broad.mit.edu	37	3	197707267	197707267	+	Nonsense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:197707267C>G	ENST00000330198.4	+	6	642	c.620C>G	c.(619-621)tCa>tGa	p.S207*	LMLN_ENST00000332636.5_Nonsense_Mutation_p.S155*|LMLN_ENST00000420910.2_Nonsense_Mutation_p.S207*|LMLN_ENST00000482695.1_Nonsense_Mutation_p.S155*	NM_033029.3	NP_149018.2	Q96KR4	LMLN_HUMAN	leishmanolysin-like (metallopeptidase M8 family)	207					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		GAAGGCATCTCAGATGCAGAC	0.537000													7	79					0	0	1	0	0
ARHGEF40	55701	broad.mit.edu	37	14	21543089	21543089	+	Silent	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr14:21543089G>T	ENST00000298694.4	+	3	1327	c.1200G>T	c.(1198-1200)ctG>ctT	p.L400L	ARHGEF40_ENST00000298693.3_Silent_p.L400L			Q8TER5	ARH40_HUMAN	Rho guanine nucleotide exchange factor (GEF) 40	400					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(4)|ovary(3)|upper_aerodigestive_tract(2)	9						GTGCCCCACTGAGCCCTGGGG	0.587000													5	38					1	1	1	1	0
ABCC11	85320	broad.mit.edu	37	16	48221148	48221148	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr16:48221148C>G	ENST00000394747.1	-	20	3246	c.2897G>C	c.(2896-2898)gGa>gCa	p.G966A	ABCC11_ENST00000353782.5_Missense_Mutation_p.G966A|ABCC11_ENST00000537808.1_3'UTR|ABCC11_ENST00000394748.1_Missense_Mutation_p.G966A|ABCC11_ENST00000565329.1_5'UTR|ABCC11_ENST00000356608.2_Missense_Mutation_p.G966A	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	966	ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GATTATGGCTCCCATTAACAG	0.453000													7	61					0	0	1	0	0
EML5	161436	broad.mit.edu	37	14	89123766	89123766	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr14:89123766C>A	ENST00000554922.1	-	27	4206	c.3958G>T	c.(3958-3960)Gga>Tga	p.G1320*	EML5_ENST00000380664.5_Nonsense_Mutation_p.G1320*|EML5_ENST00000352093.5_Nonsense_Mutation_p.G1282*	NM_183387.2	NP_899243.1	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like 5	1320						cytoplasm|microtubule				breast(1)|endometrium(3)|kidney(4)|large_intestine(17)|lung(14)|ovary(3)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						GGCTTGATTCCTAACATTGGG	0.318000													5	33					0.014758	0.0160005	1	1	0
COL17A1	1308	broad.mit.edu	37	10	105792002	105792002	+	Silent	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr10:105792002G>C	ENST00000353479.5	-	56	4775	c.4485C>G	c.(4483-4485)gtC>gtG	p.V1495V	COL17A1_ENST00000369733.3_Silent_p.V1413V	NM_000494.3	NP_000485.3	Q9UMD9	COHA1_HUMAN	collagen, type XVII, alpha 1	1495	Nonhelical region (NC1).				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|liver(1)|lung(22)|ovary(5)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	62		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		CTCACGGCTTGACAGCAATAC	0.507000													6	26					0	0	1	0	0
MAN2A1	4124	broad.mit.edu	37	5	109106220	109106220	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:109106220C>T	ENST00000261483.4	+	7	2226	c.1174C>T	c.(1174-1176)Cat>Tat	p.H392Y		NM_002372.2	NP_002363.2	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	392					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		AGAAACAATACATCCTGGAAA	0.433000													8	34					0	0	1	0	0
NAT8	9027	broad.mit.edu	37	2	73868184	73868184	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:73868184A>G	ENST00000272425.3	-	2	721	c.572T>C	c.(571-573)aTg>aCg	p.M191T		NM_003960.3|NM_016347.2	NP_003951.3|NP_057431.2	Q9UHE5	NAT8_HUMAN	N-acetyltransferase 8 (GCN5-related, putative)	191	N-acetyltransferase.				gastrulation with mouth forming second|response to drug	integral to membrane	N-acetyltransferase activity			breast(1)|endometrium(2)|kidney(2)|lung(2)|ovary(1)|prostate(1)	9						CTTGAAGCCCATGCTCTGGTA	0.547000													6	20					0	0	1	0	0
ANKS1B	56899	broad.mit.edu	37	12	99837571	99837571	+	Silent	SNP	T	T	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:99837571T>A	ENST00000547776.2	-	11	1454	c.1455A>T	c.(1453-1455)gtA>gtT	p.V485V	ANKS1B_ENST00000547010.1_Silent_p.V65V|ANKS1B_ENST00000329257.7_Silent_p.V485V	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	485						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		TAGTAACTGCTACCTCAGAGG	0.383000													16	55					0	0	1	0	0
C6orf118	168090	broad.mit.edu	37	6	165713893	165713893	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr6:165713893T>C	ENST00000543069.1	-	3	1105	c.524A>G	c.(523-525)aAc>aGc	p.N175S	C6orf118_ENST00000230301.8_Missense_Mutation_p.N279S			Q5T5N4	CF118_HUMAN	chromosome 6 open reading frame 118	279										breast(1)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		CAAAGAACTGTTACAAATATC	0.398000													25	97					0	0	1	0	0
KAT6A	7994	broad.mit.edu	37	8	41798546	41798546	+	Silent	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr8:41798546G>C	ENST00000396930.3	-	16	3396	c.2853C>G	c.(2851-2853)ctC>ctG	p.L951L	KAT6A_ENST00000265713.2_Silent_p.L951L|KAT6A_ENST00000406337.1_Silent_p.L951L	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	951					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										GGCTTTTCTTGAGCTGTCCTC	0.582000													8	116					0	0	1	0	0
LILRB1	10859	broad.mit.edu	37	19	55144176	55144176	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:55144176C>A	ENST00000396331.1	+	7	1280	c.923C>A	c.(922-924)tCg>tAg	p.S308*	LILRB1_ENST00000396321.2_Nonsense_Mutation_p.S308*|LILRB1_ENST00000396315.1_Nonsense_Mutation_p.S308*|LILRB1_ENST00000396317.1_Nonsense_Mutation_p.S308*|LILRB1_ENST00000396332.4_Nonsense_Mutation_p.S308*|LILRB1_ENST00000434867.2_Nonsense_Mutation_p.S308*|LILRB1_ENST00000427581.2_Nonsense_Mutation_p.S344*|LILRB1_ENST00000418536.2_Nonsense_Mutation_p.S308*|LILRB1_ENST00000324602.7_Nonsense_Mutation_p.S308*|LILRB1_ENST00000448689.1_Nonsense_Mutation_p.S308*|LILRB1_ENST00000396327.3_Nonsense_Mutation_p.S308*	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	308	Ig-like C2-type 3.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		TCCGAGTGGTCGGCCCCCAGC	0.687000										HNSCC(37;0.09)			10	30					1.58986e-06	2.05575e-06	1	1	0
HEPH	9843	broad.mit.edu	37	X	65480069	65480069	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:65480069G>T	ENST00000519389.1	+	19	3505	c.3326G>T	c.(3325-3327)gGc>gTc	p.G1109V	HEPH_ENST00000374727.3_Missense_Mutation_p.G1058V|HEPH_ENST00000336279.5_Missense_Mutation_p.G788V|HEPH_ENST00000419594.1_Missense_Mutation_p.G866V|HEPH_ENST00000343002.2_Missense_Mutation_p.G1055V|HEPH_ENST00000441993.2_Missense_Mutation_p.G1058V			Q9BQS7	HEPH_HUMAN	hephaestin	1055					cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(56)|ovary(5)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	89						GTCCATGCTGGCATGGAGACC	0.488000													3	41					1	1	1	1	0
MYOT	9499	broad.mit.edu	37	5	137219226	137219226	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr5:137219226G>A	ENST00000239926.4	+	7	1344	c.970G>A	c.(970-972)Gtt>Att	p.V324I	MYOT_ENST00000509812.1_Intron|RP11-381K20.2_ENST00000514616.1_RNA|MYOT_ENST00000421631.2_Missense_Mutation_p.V140I|RP11-381K20.2_ENST00000508281.2_RNA|MYOT_ENST00000515645.1_Missense_Mutation_p.V209I	NM_006790.2	NP_006781	Q9UBF9	MYOTI_HUMAN	myotilin	324	Ig-like C2-type 1.|Necessary for interaction with ACTA1.|Necessary for interaction with FLNC.				muscle contraction	actin cytoskeleton|sarcolemma|sarcomere	actin binding|structural constituent of muscle			cervix(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(1)|prostate(1)|urinary_tract(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TTATGCATGTGTTGCCAAGAA	0.443000													8	39					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94690421	94690421	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr4:94690421G>C	ENST00000282020.4	+	15	2679	c.2421G>C	c.(2419-2421)aaG>aaC	p.K807N	GRID2_ENST00000510992.1_Missense_Mutation_p.K712N	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	807					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	GGTGGCCTAAGAATGGCCAGT	0.483000													7	40					0	0	1	0	0
ATP11B	23200	broad.mit.edu	37	3	182547496	182547496	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:182547496G>T	ENST00000323116.5	+	4	531	c.271G>T	c.(271-273)Gga>Tga	p.G91*	ATP11B_ENST00000493826.1_Nonsense_Mutation_p.G91*	NM_014616.2	NP_055431.1	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	91					aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	41	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			AGTTACCAGTGGACTTCCATT	0.289000													7	56					5.4927e-09	7.45354e-09	1	1	0
HLF	3131	broad.mit.edu	37	17	53345295	53345295	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr17:53345295G>T	ENST00000226067.5	+	2	772	c.299G>T	c.(298-300)aGc>aTc	p.S100I	HLF_ENST00000430986.2_Missense_Mutation_p.S15I|HLF_ENST00000573945.1_Missense_Mutation_p.S15I|HLF_ENST00000575345.1_Missense_Mutation_p.S15I	NM_002126.4	NP_002117.1	Q16534	HLF_HUMAN	hepatic leukemia factor	100					multicellular organismal development|rhythmic process|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(2)	3						ATTCCCCCCAGCCCATCTCAG	0.582000			T	TCF3	ALL								13	75					9.31168e-06	1.17985e-05	1	1	0
LRRC31	79782	broad.mit.edu	37	3	169587498	169587498	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:169587498C>A	ENST00000316428.5	-	1	155	c.98G>T	c.(97-99)aGa>aTa	p.R33I	LRRC31_ENST00000523069.1_Missense_Mutation_p.R33I|LRRC31_ENST00000397805.2_5'UTR|LRRC31_ENST00000264676.5_Missense_Mutation_p.R33I	NM_001277127.1|NM_024727.2	NP_001264056.1|NP_079003.2	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	33										cervix(3)|endometrium(3)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	31	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			GTCCTCTTTTCTGCTTTCAGC	0.468000													3	43					0.004672	0.00517199	1	1	0
NCKAP5L	57701	broad.mit.edu	37	12	50191061	50191061	+	Silent	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr12:50191061C>G	ENST00000335999.6	-	8	783	c.582G>C	c.(580-582)ctG>ctC	p.L194L		NM_001037806.3	NP_001032895.2	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	190	Pro-rich.									central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(8)|prostate(2)	18						CCAGGGCTCTCAGCACCTCCA	0.692000													4	15					0	0	1	0	0
WDR20	91833	broad.mit.edu	37	14	102675932	102675932	+	Silent	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr14:102675932G>A	ENST00000335263.5	+	3	1505	c.1425G>A	c.(1423-1425)gaG>gaA	p.E475E	WDR20_ENST00000545563.1_Silent_p.E302E|WDR20_ENST00000556511.2_Silent_p.E414E|WDR20_ENST00000342702.3_Silent_p.E475E|WDR20_ENST00000424963.2_Silent_p.E351E|WDR20_ENST00000499851.2_Silent_p.E218E|WDR20_ENST00000322340.5_Intron|WDR20_ENST00000454394.2_Silent_p.E506E|WDR20_ENST00000556807.1_Silent_p.E414E|WDR20_ENST00000299135.6_3'UTR	NM_181291.2	NP_851808.1	Q8TBZ3	WDR20_HUMAN	WD repeat domain 20	475										breast(1)|large_intestine(2)|lung(4)|prostate(1)	8						GGCACCACGAGAAAGATCACA	0.473000											OREG0022939	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	62					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	137814362	137814362	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:137814362C>A	ENST00000409968.1	+	3	690	c.512C>A	c.(511-513)gCt>gAt	p.A171D	THSD7B_ENST00000272643.3_Missense_Mutation_p.A171D|THSD7B_ENST00000413152.2_Missense_Mutation_p.A140D|THSD7B_ENST00000543459.1_Missense_Mutation_p.A30D					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		ACAGAACAGGCTTGCCTCATT	0.502000													33	156					1.04352e-10	1.44716e-10	1	1	0
RRM1	6240	broad.mit.edu	37	11	4142986	4142986	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr11:4142986G>C	ENST00000300738.5	+	10	1233	c.1029G>C	c.(1027-1029)gaG>gaC	p.E343D	RRM1_ENST00000528470.1_3'UTR|RRM1_ENST00000537197.1_Missense_Mutation_p.E5D|RRM1_ENST00000423050.2_Missense_Mutation_p.E246D|RRM1_ENST00000534285.1_Missense_Mutation_p.E121D	NM_001033.3	NP_001024.1	P23921	RIR1_HUMAN	ribonucleotide reductase M1	343					deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleoplasm|ribonucleoside-diphosphate reductase complex	ATP binding|ribonucleoside-diphosphate reductase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)	14		Medulloblastoma(188;0.0025)|Breast(177;0.00502)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0848)|LUSC - Lung squamous cell carcinoma(625;0.205)	Clofarabine(DB00631)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Hydroxyurea(DB01005)	AACGAGTGGAGACTAATCAGG	0.403000													7	73					0	0	1	0	0
OR4Q3	441669	broad.mit.edu	37	14	20216220	20216220	+	Missense_Mutation	SNP	T	T	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr14:20216220T>A	ENST00000331723.1	+	1	634	c.634T>A	c.(634-636)Ttc>Atc	p.F212I		NM_172194.1	NP_751944.1	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q, member 3	212					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(4)|endometrium(3)|kidney(2)|large_intestine(1)|lung(28)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCTTGTCTGCTTCTTGGTCTT	0.498000													8	31					0	0	1	0	0
SLC6A2	6530	broad.mit.edu	37	16	55719100	55719100	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr16:55719100C>T	ENST00000379906.2	+	4	945	c.690C>T	c.(688-690)atC>atT	p.I230I	SLC6A2_ENST00000219833.8_Silent_p.I230I|SLC6A2_ENST00000568943.1_Silent_p.I230I|SLC6A2_ENST00000566163.1_Silent_p.I230I|SLC6A2_ENST00000561820.1_Silent_p.I230I|SLC6A2_ENST00000567238.1_Silent_p.I125I|SLC6A2_ENST00000414754.3_Silent_p.I230I	NM_001043.3	NP_001034.1	P23975	SC6A2_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 2	230					synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(3)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	TTCATGACATCGGCCTGCCCC	0.562000													6	34					0	0	1	0	0
STK11IP	114790	broad.mit.edu	37	2	220471806	220471806	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:220471806C>G	ENST00000456909.1	+	13	1256	c.1166C>G	c.(1165-1167)tCt>tGt	p.S389C	STK11IP_ENST00000295641.10_Missense_Mutation_p.S400C			Q8N1F8	S11IP_HUMAN	serine/threonine kinase 11 interacting protein	400					protein localization	cytoplasm	protein kinase binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	23		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCAAGCATCTCTGAACCCAGT	0.607000													3	11					0	0	1	0	0
CD80	941	broad.mit.edu	37	3	119263418	119263418	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:119263418C>G	ENST00000264246.3	-	3	759	c.397G>C	c.(397-399)Gaa>Caa	p.E133Q	CD80_ENST00000383668.3_Missense_Mutation_p.E133Q|CD80_ENST00000478182.1_Missense_Mutation_p.E133Q|CD80_ENST00000383669.3_Missense_Mutation_p.E133Q	NM_005191.3	NP_005182.1	P33681	CD80_HUMAN	CD80 molecule	133	Ig-like V-type.				interspecies interaction between organisms|intracellular signal transduction|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of signal transduction|positive regulation of T-helper 1 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation	intracellular	coreceptor activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	12					Abatacept(DB01281)	AACGTCACTTCAGCCAGGTGT	0.468000													7	63					0	0	1	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37730040	37730040	+	Silent	SNP	C	C	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr8:37730040C>A	ENST00000330843.4	-	4	2292	c.2280G>T	c.(2278-2280)gtG>gtT	p.V760V	RAB11FIP1_ENST00000524118.1_Intron|RAB11FIP1_ENST00000287263.4_Intron|RAB11FIP1_ENST00000522727.1_Intron|RAB11FIP1_ENST00000523182.1_5'UTR	NM_001002814.2	NP_001002814.2	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 (class I)	760					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			CTTTGCTCTCCACAAGAGACC	0.567000													6	28					0.217242	0.22074	1	1	0
LEO1	123169	broad.mit.edu	37	15	52257978	52257978	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr15:52257978G>T	ENST00000299601.5	-	2	842	c.782C>A	c.(781-783)tCa>tAa	p.S261*	LEO1_ENST00000315141.5_Nonsense_Mutation_p.S261*	NM_138792.2	NP_620147.1	Q8WVC0	LEO1_HUMAN	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	261	Asp-rich.				histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|skin(1)	14				all cancers(107;0.00264)		TTCATCATCTGAATGCCTGTG	0.403000													10	129					1.58986e-06	2.05575e-06	1	1	0
OR10R2	343406	broad.mit.edu	37	1	158450030	158450030	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr1:158450030G>A	ENST00000368152.1	+	1	363	c.363G>A	c.(361-363)atG>atA	p.M121I	RP11-144L1.4_ENST00000426251.1_RNA|RP11-144L1.4_ENST00000419738.1_RNA	NM_001004472.1	NP_001004472.1	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R, member 2	121					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(26)|pancreas(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	41	all_hematologic(112;0.0378)					CTCTTCAAATGTTCTTCTTCC	0.458000													10	126					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32703843	32703843	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:32703843G>C	ENST00000421745.2	+	36	7343	c.7209G>C	c.(7207-7209)tgG>tgC	p.W2403C		NM_016252.3	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	2403					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					GTGGTGCTTGGGCTCAGTATT	0.403000													5	46					0	0	1	0	0
SOWAHC	65124	broad.mit.edu	37	2	110373434	110373434	+	Silent	SNP	A	A	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr2:110373434A>G	ENST00000356454.3	+	1	1524	c.1368A>G	c.(1366-1368)ccA>ccG	p.P456P		NM_023016.3	NP_075392.2	Q53LP3	ANR57_HUMAN	sosondowah ankyrin repeat domain family member C	456																	CCAAGGATCCAGGGCGCAAAG	0.557000													4	27					0	0	1	0	0
SLC9A7	84679	broad.mit.edu	37	X	46466593	46466593	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chrX:46466593C>T	ENST00000328306.4	-	17	1997	c.1972G>A	c.(1972-1974)Gaa>Aaa	p.E658K	SLC9A7_ENST00000464933.1_5'UTR	NM_001257291.1|NM_032591.2	NP_001244220.1|NP_115980.1	Q96T83	SL9A7_HUMAN	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7	658					regulation of pH	Golgi membrane|integral to membrane|recycling endosome membrane|trans-Golgi network	potassium:hydrogen antiporter activity|protein homodimerization activity|sodium:hydrogen antiporter activity			breast(2)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)|skin(1)	21						AGGTCGCCTTCGGTCAGGATG	0.517000													5	9					0	0	1	0	0
SOS2	6655	broad.mit.edu	37	14	50611890	50611890	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr14:50611890C>G	ENST00000216373.5	-	16	2939	c.2665G>C	c.(2665-2667)Gag>Cag	p.E889Q	SOS2_ENST00000543680.1_Missense_Mutation_p.E856Q	NM_006939.2	NP_008870.2	Q07890	SOS2_HUMAN	son of sevenless homolog 2 (Drosophila)	889	Ras-GEF.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(16)|ovary(2)|skin(1)	39	all_epithelial(31;0.000822)|Breast(41;0.0065)					AAACTTACCTCAAAGGTATGG	0.308000													5	51					0	0	1	0	0
SPATA31A7	26165	broad.mit.edu	37	9	65507551	65507551	+	Silent	SNP	C	C	T			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr9:65507551C>T	ENST00000355045.2	-	3	292	c.264G>A	c.(262-264)ccG>ccA	p.P88P	SPATA31A7_ENST00000491812.2_5'UTR	NM_015667.2	NP_056482.2			SPATA31 subfamily A, member 7																		CCAGGCCTCTCGGGCACTCTC	0.602000													7	73					0	0	1	0	0
IQCB1	9657	broad.mit.edu	37	3	121515999	121515999	+	Frame_Shift_Del	DEL	A	A	-			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr3:121515999delA	ENST00000310864.6	-	9	1056	c.842delT	c.(841-843)ttafs	p.L281fs	IQCB1_ENST00000349820.6_Intron	NM_001023570.2	NP_001018864.2	Q15051	IQCB1_HUMAN	IQ motif containing B1	281					cilium assembly|maintenance of organ identity|photoreceptor cell maintenance	centrosome|photoreceptor connecting cilium	calmodulin binding			NS(1)|biliary_tract(1)|breast(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(11)|prostate(1)|skin(1)	30				GBM - Glioblastoma multiforme(114;0.0983)		CATTGGGCTTAAAAGGCCAAC	0.358													8	97	---	---	---	---					
PMS2P3	5387	broad.mit.edu	37	7	75142142	75142142	+	RNA	DEL	A	A	-	rs35519730		TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr7:75142142delA	ENST00000418756.1	-	0	991					NR_028059.1															lung(1)	1						tctcaaaaagaaaaaaaaaaa	0.418													4	7	---	---	---	---					
CDKN2A	1029	broad.mit.edu	37	9	21971055	21971056	+	Frame_Shift_Ins	INS	-	-	CCGG			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr9:21971055_21971056insCCGG	ENST00000579755.1	-	2	637_638	c.345_346insCCGG	c.(343-348)cggggcfs	p.RG115fs	CDKN2A_ENST00000479692.2_Frame_Shift_Ins_p.-50fs|CDKN2A_ENST00000494262.1_Frame_Shift_Ins_p.-50fs|CDKN2A_ENST00000578845.2_Frame_Shift_Ins_p.-50fs|CDKN2A_ENST00000530628.2_Frame_Shift_Ins_p.RG115fs|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000446177.1_Frame_Shift_Ins_p.-101fs|CDKN2A_ENST00000498124.1_Frame_Shift_Ins_p.-101fs|CDKN2A_ENST00000579122.1_Frame_Shift_Ins_p.-101fs|CDKN2A_ENST00000498628.2_Frame_Shift_Ins_p.-50fs|CDKN2A_ENST00000361570.3_Frame_Shift_Ins_p.RG156fs|CDKN2A_ENST00000497750.1_Frame_Shift_Ins_p.-50fs|CDKN2A_ENST00000304494.5_Frame_Shift_Ins_p.-101fs			P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	131					cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(44)|p.G101G(3)|p.H83fs*2(2)|p.A102fs*18(1)|p.0(1)|p.G101fs*17(1)|p.T93_D105del(1)|p.A68fs*3(1)|p.A102fs*42(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CCAGCCGCGCCCCGGCCCGGTG	0.752		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			8	17	---	---	---	---					
TYK2	7297	broad.mit.edu	37	19	10475559	10475559	+	Frame_Shift_Del	DEL	C	C	-			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:10475559delC	ENST00000525621.1	-	8	1658	c.1177delG	c.(1177-1179)gtcfs	p.V393fs	TYK2_ENST00000264818.6_Frame_Shift_Del_p.V393fs|TYK2_ENST00000529370.1_Frame_Shift_Del_p.V393fs|TYK2_ENST00000524462.1_Frame_Shift_Del_p.V208fs	NM_003331.4	NP_003322.3	P29597	TYK2_HUMAN	tyrosine kinase 2	393	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(11)|kidney(6)|large_intestine(3)|lung(19)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			TGGATGCTGACACAGTGCTCT	0.657													14	64	---	---	---	---					
GRIK5	2901	broad.mit.edu	37	19	42569896	42569898	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-XF-A9SY-01A-21D-A42E-08	TCGA-XF-A9SY-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9bc4f3e6-da15-4d23-ab79-bc4e6271d1ae	b3ea5dfa-2b60-4ce0-923d-30e2a876e31b	g.chr19:42569896_42569898delCAG	ENST00000262895.3	-	1	24_26	c.25_27delCTG	c.(25-27)ctgdel	p.L9del	GRIK5_ENST00000593562.1_In_Frame_Del_p.L9del|GRIK5_ENST00000301218.4_In_Frame_Del_p.L9del	NM_002088.4	NP_002079.3	Q16478	GRIK5_HUMAN	glutamate receptor, ionotropic, kainate 5	9						cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	35		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	AGGCAACAATCAGCAGCAGCAGC	0.695													2	4	---	---	---	---					
