Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CENPO	79172	broad.mit.edu	37	2	25038559	25038559	+	Silent	SNP	C	C	T			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr2:25038559C>T	ENST00000380834.2	+	5	953	c.528C>T	c.(526-528)ttC>ttT	p.F176F	CENPO_ENST00000260662.1_Silent_p.F176F|CENPO_ENST00000473706.1_Silent_p.F170F			Q9BU64	CENPO_HUMAN	centromere protein O	176					cell division|CenH3-containing nucleosome assembly at centromere|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(2)|kidney(1)|large_intestine(3)|lung(1)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					TCCAGCACTTCCTGTTCAGTC	0.483000													14	63					0	0	1	0	0
OLFML2A	169611	broad.mit.edu	37	9	127572129	127572129	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr9:127572129G>A	ENST00000373580.3	+	8	1397	c.1397G>A	c.(1396-1398)gGc>gAc	p.G466D	OLFML2A_ENST00000288815.5_Missense_Mutation_p.G252D	NM_182487.2	NP_872293.2	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A	466	Olfactomedin-like.									endometrium(5)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	25						AACTGGATCGGCACAGGCCAC	0.612000													3	41					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51175492	51175492	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr16:51175492G>A	ENST00000440970.1	-	2	781	c.350C>T	c.(349-351)gCg>gTg	p.A117V	SALL1_ENST00000541611.1_Intron|SALL1_ENST00000566102.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.A214V	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	214					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GCCGCACCTCGCTTCCTGGGA	0.602000													6	71					0	0	1	0	0
HSPB2	3316	broad.mit.edu	37	11	111784414	111784414	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr11:111784414G>A	ENST00000304298.3	+	2	932	c.344G>A	c.(343-345)cGa>cAa	p.R115Q	HSPB2-C11orf52_ENST00000534100.1_Intron|CRYAB_ENST00000527950.1_Intron|HSPB2_ENST00000537382.1_Missense_Mutation_p.R115Q|CRYAB_ENST00000533475.1_5'UTR	NM_001541.3	NP_001532.1	Q16082	HSPB2_HUMAN	heat shock 27kDa protein 2	115					response to heat|response to unfolded protein	cytosol|nucleus	enzyme activator activity|protein binding			large_intestine(2)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10		all_cancers(61;3.75e-11)|all_epithelial(67;2.33e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;3.57e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|all cancers(92;6.57e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.051)		TTCGTGTCCCGAGAGTTCTGC	0.622000													3	29					0	0	1	0	0
COQ5	84274	broad.mit.edu	37	12	120954536	120954536	+	Silent	SNP	C	C	T			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr12:120954536C>T	ENST00000288532.6	-	3	448	c.408G>A	c.(406-408)caG>caA	p.Q136Q	COQ5_ENST00000445328.2_Intron	NM_032314.3	NP_115690.3	Q5HYK3	COQ5_HUMAN	coenzyme Q5 homolog, methyltransferase (S. cerevisiae)	136					ubiquinone biosynthetic process	mitochondrion	methyltransferase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(1)|prostate(1)|urinary_tract(3)	20	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ACTGCCTCTTCTGTTTTCTCT	0.443000													14	153					0	0	1	0	0
ANGPT1	284	broad.mit.edu	37	8	108306213	108306213	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr8:108306213C>T	ENST00000520734.1	-	5	674	c.389G>A	c.(388-390)cGt>cAt	p.R130H	ANGPT1_ENST00000518386.1_5'UTR|ANGPT1_ENST00000520052.1_Missense_Mutation_p.R129H			Q15389	ANGP1_HUMAN	angiopoietin 1	330					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			NS(1)|breast(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(13)|ovary(4)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	43	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			TCCATCTTCACGATGTTGTAT	0.343000													7	87					0	0	1	0	0
LRRTM1	347730	broad.mit.edu	37	2	80530672	80530672	+	Silent	SNP	G	G	T			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr2:80530672G>T	ENST00000295057.3	-	2	929	c.273C>A	c.(271-273)ctC>ctA	p.L91L	CTNNA2_ENST00000361291.4_Intron|CTNNA2_ENST00000541047.1_Intron|CTNNA2_ENST00000496558.1_Intron|LRRTM1_ENST00000409148.1_Silent_p.L91L|CTNNA2_ENST00000540488.1_Intron|CTNNA2_ENST00000466387.1_Intron|CTNNA2_ENST00000402739.4_Intron	NM_178839.4	NP_849161.2	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	91						axon|endoplasmic reticulum membrane|growth cone|integral to membrane				NS(1)|breast(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(33)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	63						AGAGCCACGTGAGCTGCATTA	0.612000										HNSCC(69;0.2)			5	62					3.59834e-05	3.8465e-05	1	1	0
ANKRD30B	374860	broad.mit.edu	37	18	14763786	14763786	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr18:14763786C>T	ENST00000358984.4	+	7	1102	c.922C>T	c.(922-924)Cgc>Tgc	p.R308C	ANKRD30B_ENST00000447268.2_Missense_Mutation_p.R308C|ANKRD30B_ENST00000579292.1_Intron	NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	308								p.R308G(2)		breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						CGAGGCTGCACGCTTGGTGGA	0.483000													3	29					0	0	1	0	0
INF2	64423	broad.mit.edu	37	14	105169748	105169748	+	Silent	SNP	C	C	T			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr14:105169748C>T	ENST00000392634.4	+	4	736	c.624C>T	c.(622-624)ccC>ccT	p.P208P	INF2_ENST00000398337.4_Silent_p.P208P|INF2_ENST00000330634.7_Silent_p.P208P	NM_022489.3	NP_071934.3	Q27J81	INF2_HUMAN	inverted formin, FH2 and WH2 domain containing	208	GBD/FH3.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		TCTTGGGCCCCGAGGACCTGC	0.642000													7	41					0	0	1	0	0
COQ5	84274	broad.mit.edu	37	12	120954398	120954398	+	Silent	SNP	C	C	T			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr12:120954398C>T	ENST00000288532.6	-	3	586	c.546G>A	c.(544-546)caG>caA	p.Q182Q	COQ5_ENST00000445328.2_Intron	NM_032314.3	NP_115690.3	Q5HYK3	COQ5_HUMAN	coenzyme Q5 homolog, methyltransferase (S. cerevisiae)	182					ubiquinone biosynthetic process	mitochondrion	methyltransferase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(1)|prostate(1)|urinary_tract(3)	20	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCAAGGCTTTCTGCTTTCCAA	0.438000													20	262					0	0	1	0	0
AZGP1	563	broad.mit.edu	37	7	99565998	99565998	+	Silent	SNP	G	G	A			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr7:99565998G>A	ENST00000411734.1	-	3	389	c.384C>T	c.(382-384)agC>agT	p.S128S	AZGP1_ENST00000292401.4_Silent_p.S131S			P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc-binding	131					antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|stomach(1)	16	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					AGAATGCTCCGCTGCTTCTGT	0.498000													54	173					0	0	1	0	0
ADAM10	102	broad.mit.edu	37	15	58938351	58938351	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr15:58938351C>T	ENST00000260408.3	-	6	1081	c.638G>A	c.(637-639)cGt>cAt	p.R213H	ADAM10_ENST00000396140.2_Intron|ADAM10_ENST00000561288.1_Intron|ADAM10_ENST00000402627.1_Intron	NM_001110.2	NP_001101.1	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10	213					cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			breast(1)|endometrium(1)|kidney(5)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)	27				GBM - Glioblastoma multiforme(80;0.202)		TGAAGTTGTACGTTTTTTCCT	0.348000													8	40					0	0	1	0	0
DSEL	92126	broad.mit.edu	37	18	65178556	65178556	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr18:65178556G>A	ENST00000310045.7	-	2	4793	c.3320C>T	c.(3319-3321)tCc>tTc	p.S1107F	CTD-2541J13.2_ENST00000583493.1_RNA	NM_032160.2	NP_115536.1	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	1097						integral to membrane	isomerase activity|sulfotransferase activity			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(25)|lung(23)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)				AGACAAGAGGGACACTGCATT	0.393000													7	53					0	0	1	0	0
AKR1C4	1109	broad.mit.edu	37	10	5255048	5255048	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr10:5255048C>T	ENST00000380448.1	+	9	1025	c.772C>T	c.(772-774)Cgc>Tgc	p.R258C	AKR1C4_ENST00000263126.1_Missense_Mutation_p.R258C			P17516	AK1C4_HUMAN	aldo-keto reductase family 1, member C4	258					androgen metabolic process|bile acid biosynthetic process	cytosol	aldo-keto reductase (NADP) activity|androsterone dehydrogenase (B-specific) activity|bile acid transmembrane transporter activity|chlordecone reductase activity|electron carrier activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|skin(2)|stomach(2)|urinary_tract(1)	18					NADH(DB00157)	GATTGCCCTGCGCTACCAGCT	0.562000													3	23					0	0	1	0	0
CTNNA2	1496	broad.mit.edu	37	2	80831274	80831274	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr2:80831274G>A	ENST00000466387.1	+	20	2989	c.2265G>A	c.(2263-2265)atG>atA	p.M755I	CTNNA2_ENST00000361291.4_Missense_Mutation_p.M789I|CTNNA2_ENST00000541047.1_Missense_Mutation_p.M755I|AC008067.2_ENST00000430876.1_RNA|CTNNA2_ENST00000496558.1_Missense_Mutation_p.M755I|AC008067.2_ENST00000596783.1_RNA|CTNNA2_ENST00000540488.1_Missense_Mutation_p.M755I|AC008067.2_ENST00000599412.2_RNA|AC008067.2_ENST00000596887.1_RNA|AC008067.2_ENST00000595478.1_RNA|CTNNA2_ENST00000343114.3_Missense_Mutation_p.M434I|AC008067.2_ENST00000609950.1_RNA|CTNNA2_ENST00000402739.4_Missense_Mutation_p.M755I			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	755					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						GTTCTCGAATGGACAAATTAG	0.423000													8	33					0	0	1	0	0
CDH7	1005	broad.mit.edu	37	18	63547696	63547696	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr18:63547696G>A	ENST00000397968.2	+	12	2350	c.1924G>A	c.(1924-1926)Gaa>Aaa	p.E642K	CDH7_ENST00000323011.3_Missense_Mutation_p.E642K	NM_004361.2	NP_004352.2	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	642					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				TATTTTTGACGAAGAAAGAGA	0.438000													4	46					0	0	1	0	0
OR5A2	219981	broad.mit.edu	37	11	59189982	59189982	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr11:59189982C>T	ENST00000302040.4	-	1	467	c.445G>A	c.(445-447)Gcc>Acc	p.A149T		NM_001001954.1	NP_001001954.1	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A, member 2	149					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|liver(1)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	21						CCCACATAGGCGCCAACCACC	0.453000													3	24					0	0	1	0	0
PRMT8	56341	broad.mit.edu	37	12	3678685	3678685	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr12:3678685G>A	ENST00000382622.3	+	6	1057	c.667G>A	c.(667-669)Gtg>Atg	p.V223M	PRMT8_ENST00000261252.4_3'UTR|PRMT8_ENST00000452611.2_Missense_Mutation_p.V214M	NM_019854.4	NP_062828.3	Q9NR22	ANM8_HUMAN	protein arginine methyltransferase 8	223					regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			AGCTTTGTACGTGGTAGCGAT	0.488000													4	39					0	0	1	0	0
NT5E	4907	broad.mit.edu	37	6	86181106	86181106	+	Silent	SNP	C	C	G			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr6:86181106C>G	ENST00000257770.3	+	3	763	c.714C>G	c.(712-714)gtC>gtG	p.V238V	NT5E_ENST00000369651.3_Silent_p.V238V|NT5E_ENST00000369646.3_Silent_p.V238V	NM_002526.3	NP_002517.1	P21589	5NTD_HUMAN	5'-nucleotidase, ecto (CD73)	238					DNA metabolic process|purine base metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	5'-nucleotidase activity|nucleotide binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(76;0.000215)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0427)		BRCA - Breast invasive adenocarcinoma(108;0.0417)	Pentoxifylline(DB00806)	GTGTGGACGTCGTGGTGGGAG	0.423000													9	26					0	0	1	0	0
PRB4	5545	broad.mit.edu	37	12	11461589	11461589	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr12:11461589A>G	ENST00000279575.1	-	3	361	c.328T>C	c.(328-330)Tcc>Ccc	p.S110P	PRB4_ENST00000445719.2_Missense_Mutation_p.S110P|PRB4_ENST00000535904.1_Missense_Mutation_p.S110P	NM_001261399.1|NM_002723.4	NP_001248328.1|NP_002714.2	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	152	9.5 X 21 AA tandem repeats of K-P-[EQ]- [GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]- [RG]-[PT]-P-P-[PH]-P-G.					extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|skin(4)|upper_aerodigestive_tract(3)	30						GTACCTTGGGACTGGTTTCCT	0.602000										HNSCC(22;0.051)			4	154					0	0	1	0	0
HOXA13	3209	broad.mit.edu	37	7	27237921	27237921	+	Missense_Mutation	SNP	T	T	G			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr7:27237921T>G	ENST00000222753.4	-	2	1091	c.1063A>C	c.(1063-1065)Ata>Cta	p.I355L		NM_000522.4	NP_000513.2	P31271	HXA13_HUMAN	homeobox A13	355					skeletal system development	nucleus	sequence-specific DNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	6						GTGGCTGATATCCGCCTCCGT	0.453000			T	NUP98	AML								18	183					0	0	1	0	0
PRKAG2	51422	broad.mit.edu	37	7	151483604	151483604	+	Silent	SNP	C	C	T			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr7:151483604C>T	ENST00000287878.4	-	2	642	c.138G>A	c.(136-138)ccG>ccA	p.P46P	PRKAG2_ENST00000461529.1_5'UTR|PRKAG2_ENST00000392801.2_Silent_p.P2P	NM_016203.3	NP_057287.2	Q9UGJ0	AAKG2_HUMAN	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	46					ATP biosynthetic process|carnitine shuttle|cell cycle arrest|fatty acid biosynthetic process|glycogen metabolic process|insulin receptor signaling pathway|intracellular protein kinase cascade|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein kinase activity|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation|regulation of glucose import|regulation of glycolysis|sterol biosynthetic process	AMP-activated protein kinase complex|cytosol|nucleoplasm	ADP binding|ATP binding|cAMP-dependent protein kinase inhibitor activity|cAMP-dependent protein kinase regulator activity|phosphorylase kinase regulator activity|protein kinase activator activity|protein kinase binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|upper_aerodigestive_tract(1)	26	all_neural(206;0.187)	all_hematologic(28;0.0605)	OV - Ovarian serous cystadenocarcinoma(82;0.00252)	UCEC - Uterine corpus endometrioid carcinoma (81;0.185)		CGTCCAGGAGCGGCATGGCGA	0.597000													3	10					0	0	1	0	0
SP140	11262	broad.mit.edu	37	2	231174699	231174699	+	Missense_Mutation	SNP	A	A	C			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr2:231174699A>C	ENST00000392045.3	+	23	2233	c.2119A>C	c.(2119-2121)Act>Cct	p.T707P	SP140_ENST00000486687.2_Missense_Mutation_p.T631P|SP140_ENST00000343805.6_Missense_Mutation_p.T647P|SP140_ENST00000350136.5_Missense_Mutation_p.T576P|SP140_ENST00000417495.3_Missense_Mutation_p.T593P|SP140_ENST00000420434.3_Missense_Mutation_p.T680P	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	707					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		CTGTTGCGACACTTGTTCAAG	0.512000													4	46					0	0	1	0	0
GALNT11	63917	broad.mit.edu	37	7	151805363	151805363	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr7:151805363C>A	ENST00000434507.1	+	8	1390	c.953C>A	c.(952-954)gCa>gAa	p.A318E	GALNT11_ENST00000422997.2_3'UTR|GALNT11_ENST00000430044.2_Missense_Mutation_p.A318E|GALNT11_ENST00000452146.2_Missense_Mutation_p.A237E|GALNT11_ENST00000320311.2_Missense_Mutation_p.A318E			Q8NCW6	GLT11_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)	318						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|prostate(5)|skin(2)	27	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.214)	OV - Ovarian serous cystadenocarcinoma(82;0.00168)	UCEC - Uterine corpus endometrioid carcinoma (81;0.177)|BRCA - Breast invasive adenocarcinoma(188;0.0932)		GGAGCCACTGCACCAATAAAG	0.468000													12	42					1.61879e-10	1.82482e-10	1	1	0
CHRNA2	1135	broad.mit.edu	37	8	27319223	27319223	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr8:27319223G>A	ENST00000407991.1	-	7	2121	c.1513C>T	c.(1513-1515)Ctc>Ttc	p.L505F	CHRNA2_ENST00000240132.2_Missense_Mutation_p.L490F|CHRNA2_ENST00000520933.2_Missense_Mutation_p.L505F	NM_000742.3	NP_000733.2	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha 2 (neuronal)	505						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine Iodide(DB00416)|Metocurine(DB01336)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	AACAGCCAGAGGAAGATCCTG	0.567000													6	50					0	0	1	0	0
RBM4	5936	broad.mit.edu	37	11	66411553	66411553	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr11:66411553C>G	ENST00000409406.1	+	2	1822	c.1045C>G	c.(1045-1047)Cgg>Ggg	p.R349G	RBM14-RBM4_ENST00000412278.2_Missense_Mutation_p.R324G|RBM4_ENST00000398692.4_Intron|RBM4_ENST00000310092.7_Missense_Mutation_p.R349G|RBM4_ENST00000514361.3_Missense_Mutation_p.R324G|RBM4_ENST00000530235.1_Intron|RBM4_ENST00000506523.2_Intron|RBM4_ENST00000408993.2_Missense_Mutation_p.R349G|RBM14-RBM4_ENST00000500635.2_Intron|RBM4_ENST00000503028.2_Missense_Mutation_p.R349G|RBM4_ENST00000578778.1_Intron|RBM4_ENST00000515838.2_3'UTR|RBM4_ENST00000396053.4_Intron					RNA binding motif protein 4											endometrium(3)|large_intestine(4)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13				Lung(977;0.0112)|LUSC - Lung squamous cell carcinoma(976;0.0266)		CGACATGGCCCGGTATGAGCG	0.592000													5	35					0	0	1	0	0
OR4D10	390197	broad.mit.edu	37	11	59245414	59245414	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr11:59245414C>A	ENST00000530162.1	+	1	569	c.512C>A	c.(511-513)cCc>cAc	p.P171H		NM_001004705.1	NP_001004705.1	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D, member 10	171					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TTCTGCGGACCCAATGTTCTT	0.498000													13	68					1.49906e-05	1.63056e-05	1	1	0
TNP2	7142	broad.mit.edu	37	16	11362879	11362879	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr16:11362879G>A	ENST00000312693.3	-	1	310	c.241C>T	c.(241-243)Cgc>Tgc	p.R81C	RMI2_ENST00000572173.1_Intron	NM_005425.4	NP_005416.1	Q05952	STP2_HUMAN	transition protein 2 (during histone to protamine replacement)	81					cell differentiation|multicellular organismal development|spermatogenesis	nucleosome|nucleus	DNA binding	p.0?(1)|p.R81C(1)		large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	6						TTTTTGTGGCGCTTTGGTGGT	0.602000													17	56					0	0	1	0	0
CTSA	5476	broad.mit.edu	37	20	44526704	44526704	+	Missense_Mutation	SNP	G	G	A	rs137854547		TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr20:44526704G>A	ENST00000372484.3	+	14	1651	c.1369G>A	c.(1369-1371)Ggc>Agc	p.G457S	CTSA_ENST00000354880.5_Missense_Mutation_p.G440S|CTSA_ENST00000191018.5_Missense_Mutation_p.G439S|CTSA_ENST00000372459.2_Missense_Mutation_p.G439S	NM_000308.2|NM_001127695.1	NP_000299.2|NP_001121167.1	P10619	PPGB_HUMAN	cathepsin A	439					intracellular protein transport|proteolysis	endoplasmic reticulum|lysosome|nucleus	enzyme activator activity|protein binding|serine-type carboxypeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|skin(2)|urinary_tract(1)	21		Myeloproliferative disorder(115;0.0122)				GCAGATTGCCGGCTTCGTGAA	0.602000													4	29					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385762	58385762	+	Silent	SNP	C	C	G			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr19:58385762C>G	ENST00000435989.2	-	3	1230	c.996G>C	c.(994-996)tcG>tcC	p.S332S	ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000600634.1_Intron|ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000595295.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	332					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.S332S(2)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						ATTTGCTAAACGATTTCCCAC	0.358000													2	1					0	0	1	0	0
BOC	91653	broad.mit.edu	37	3	113002379	113002379	+	Silent	SNP	C	C	T	rs143638588		TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr3:113002379C>T	ENST00000495514.1	+	16	3257	c.2553C>T	c.(2551-2553)agC>agT	p.S851S	BOC_ENST00000273395.4_Silent_p.S852S|BOC_ENST00000355385.3_Silent_p.S851S			Q9BWV1	BOC_HUMAN	BOC cell adhesion associated, oncogene regulated	851					cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	68			Epithelial(53;0.227)			CTCGCTCCAGCGACCTGCCCT	0.627000													6	65					0	0	1	0	0
PCDHB6	56130	broad.mit.edu	37	5	140530694	140530694	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr5:140530694G>A	ENST00000231136.1	+	1	856	c.856G>A	c.(856-858)Gtc>Atc	p.V286I	PCDHB6_ENST00000543635.1_Missense_Mutation_p.V150I	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		286	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGTCGATGACGTCAACCAACC	0.468000													8	39					0	0	1	0	0
CAND1	55832	broad.mit.edu	37	12	67700355	67700355	+	Silent	SNP	G	G	A			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr12:67700355G>A	ENST00000545606.1	+	10	3344	c.2907G>A	c.(2905-2907)cgG>cgA	p.R969R		NM_018448.3	NP_060918.2	Q86VP6	CAND1_HUMAN	cullin-associated and neddylation-dissociated 1	969					cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)	35			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		TCCTTCCACGGCTTAAGGGGT	0.368000													3	38					0	0	1	0	0
CYLC2	1539	broad.mit.edu	37	9	105765522	105765522	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr9:105765522C>G	ENST00000374798.3	+	3	227	c.157C>G	c.(157-159)Caa>Gaa	p.Q53E	CYLC2_ENST00000487798.1_Missense_Mutation_p.Q53E	NM_001340.3	NP_001331.1	Q14093	CYLC2_HUMAN	cylicin, basic protein of sperm head cytoskeleton 2	53	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton	p.Q53*(1)		NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)	41		all_hematologic(171;0.125)				AAAACCTTCTCAAATACGGGA	0.328000													7	35					0	0	1	0	0
ACOX2	8309	broad.mit.edu	37	3	58516233	58516233	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr3:58516233G>A	ENST00000302819.5	-	8	1243	c.952C>T	c.(952-954)Cgc>Tgc	p.R318C	ACOX2_ENST00000459701.2_Missense_Mutation_p.R304C	NM_003500.3	NP_003491.1	Q99424	ACOX2_HUMAN	acyl-CoA oxidase 2, branched chain	318					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|acyl-CoA dehydrogenase activity|pristanoyl-CoA oxidase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(3)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(55;0.000194)|Kidney(10;0.00255)|KIRC - Kidney renal clear cell carcinoma(10;0.00268)|OV - Ovarian serous cystadenocarcinoma(275;0.156)		ACCGAGTAGCGCATGGCGATG	0.617000													6	19					0	0	1	0	0
CHD8	57680	broad.mit.edu	37	14	21873401	21873401	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr14:21873401G>A	ENST00000399982.2	-	15	3338	c.3274C>T	c.(3274-3276)Cgc>Tgc	p.R1092C	CHD8_ENST00000555962.1_Intron|CHD8_ENST00000430710.3_Missense_Mutation_p.R813C|CHD8_ENST00000557364.1_Missense_Mutation_p.R1092C	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1092					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		CAGCACTTGCGCAACTCCATC	0.433000													3	19					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181726215	181726215	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr1:181726215G>T	ENST00000526775.1	+	29	4390	c.4225G>T	c.(4225-4227)Gag>Tag	p.E1409*	CACNA1E_ENST00000367570.1_Nonsense_Mutation_p.E1428*|CACNA1E_ENST00000360108.3_Nonsense_Mutation_p.E1409*|CACNA1E_ENST00000367573.2_Nonsense_Mutation_p.E1428*|CACNA1E_ENST00000358338.5_Nonsense_Mutation_p.E1360*|CACNA1E_ENST00000367567.4_Nonsense_Mutation_p.E1035*|CACNA1E_ENST00000357570.5_Nonsense_Mutation_p.E1379*	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1428					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CACCTTCCAGGAGCAAGGGGA	0.458000													4	38					0.150653	0.150653	1	1	0
LCT	3938	broad.mit.edu	37	2	136567430	136567430	+	Silent	SNP	C	C	T			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr2:136567430C>T	ENST00000264162.2	-	8	2497	c.2487G>A	c.(2485-2487)agG>agA	p.R829R		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	829	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		TCCTGGGAGTCCTTGACTTGC	0.498000													7	86					0	0	1	0	0
IQCD	115811	broad.mit.edu	37	12	113645362	113645362	+	Missense_Mutation	SNP	C	C	T	rs138534349	byFrequency	TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr12:113645362C>T	ENST00000546692.1	-	2	983	c.610G>A	c.(610-612)Gaa>Aaa	p.E204K	IQCD_ENST00000416617.2_Missense_Mutation_p.E204K|IQCD_ENST00000299732.2_Missense_Mutation_p.E204K			Q96DY2	IQCD_HUMAN	IQ motif containing D	204										endometrium(2)|large_intestine(4)|lung(1)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	12						TCCCTCGCTTCCATGGGACTA	0.428000													11	107					0	0	1	0	0
TTC26	79989	broad.mit.edu	37	7	138865896	138865896	+	Silent	SNP	C	C	T	rs146982986	byFrequency	TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr7:138865896C>T	ENST00000464848.1	+	16	1451	c.1371C>T	c.(1369-1371)tcC>tcT	p.S457S	TTC26_ENST00000343187.4_Silent_p.S426S|TTC26_ENST00000430935.1_Silent_p.S457S|TTC26_ENST00000478836.2_Silent_p.S350S|TTC26_ENST00000495038.1_Silent_p.S326S			A0AVF1	TTC26_HUMAN	tetratricopeptide repeat domain 26	457							binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	24						TGGAAACCTCCGGCGAGTCCT	0.373000													4	65					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114199062	114199062	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr4:114199062C>T	ENST00000357077.4	+	16	1806	c.1753C>T	c.(1753-1755)Cgc>Tgc	p.R585C	ANK2_ENST00000264366.6_Missense_Mutation_p.R585C|ANK2_ENST00000394537.3_Missense_Mutation_p.R585C|ANK2_ENST00000506722.1_Missense_Mutation_p.R564C	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	585					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TCTCTTGCAACGCCGTGCTGC	0.408000													7	23					0	0	1	0	0
ETAA1	54465	broad.mit.edu	37	2	67630623	67630623	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr2:67630623G>A	ENST00000272342.5	+	5	939	c.809G>A	c.(808-810)aGt>aAt	p.S270N	ETAA1_ENST00000462772.1_Intron	NM_019002.3	NP_061875.2	Q9NY74	ETAA1_HUMAN	Ewing tumor-associated antigen 1	270						cytoplasm|nucleus				autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(3)|prostate(1)|stomach(3)|urinary_tract(1)	33						CAAAATAGCAGTCAGAAGCCA	0.373000													15	49					0	0	1	0	0
HIST1H2BK	85236	broad.mit.edu	37	6	27114540	27114540	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr6:27114540T>C	ENST00000396891.4	-	1	79	c.38A>G	c.(37-39)aAg>aGg	p.K13R	HIST1H2BK_ENST00000356950.1_Missense_Mutation_p.K13R	NM_080593.2	NP_542160.1	O60814	H2B1K_HUMAN	histone cluster 1, H2bk	13					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	13						CTTCGAGCCCTTCTTGGGCGC	0.582000													8	75					0	0	1	0	0
ARSH	347527	broad.mit.edu	37	X	2933065	2933065	+	Missense_Mutation	SNP	C	C	T	rs140056528		TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chrX:2933065C>T	ENST00000381130.2	+	4	395	c.395C>T	c.(394-396)cCg>cTg	p.P132L		NM_001011719.1	NP_001011719.1	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H	132						integral to membrane	arylsulfatase activity|metal ion binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(6)|lung(13)|skin(1)|stomach(1)	34		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				TGTTACCACCCGCTCAACCAT	0.498000													10	13					0	0	1	0	0
ZBTB49	166793	broad.mit.edu	37	4	4322688	4322688	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr4:4322688C>G	ENST00000337872.4	+	8	2064	c.1943C>G	c.(1942-1944)tCt>tGt	p.S648C	ZBTB49_ENST00000355834.3_Missense_Mutation_p.S526C|ZBTB49_ENST00000538529.1_Missense_Mutation_p.S131C	NM_145291.3	NP_660334.3	Q6ZSB9	ZBT49_HUMAN	zinc finger and BTB domain containing 49	648					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	28						GATAGCCACTCTGGCGGCTCC	0.507000													5	19					0	0	1	0	0
PTPN4	5775	broad.mit.edu	37	2	120723086	120723086	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr2:120723086G>A	ENST00000263708.2	+	25	3194	c.2423G>A	c.(2422-2424)cGt>cAt	p.R808H	PTPN4_ENST00000544261.1_Missense_Mutation_p.R441H	NM_002830.3	NP_002821.1	P29074	PTN4_HUMAN	protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)	808	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity	p.R808H(1)		endometrium(3)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|urinary_tract(1)	30					Alendronate(DB00630)	AATGAAAGTCGTCCACTCACT	0.378000													4	50					0	0	1	0	0
ZNF106	64397	broad.mit.edu	37	15	42740283	42740283	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr15:42740283C>T	ENST00000263805.4	-	3	3379	c.3053G>A	c.(3052-3054)cGa>cAa	p.R1018Q	ZNF106_ENST00000565611.1_Missense_Mutation_p.R203Q|ZNF106_ENST00000565380.1_Missense_Mutation_p.R246Q	NM_001284306.1|NM_001284307.1|NM_022473.1	NP_001271235.1|NP_001271236.1|NP_071918.1			zinc finger protein 106																		AGTGGCTCTTCGTTTCTTTCT	0.443000													22	83					0	0	1	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202648	140202648	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr5:140202648G>T	ENST00000529859.1	+	1	1288	c.1288G>T	c.(1288-1290)Ggc>Tgc	p.G430C	PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000378126.3_Missense_Mutation_p.G430C|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529619.1_Missense_Mutation_p.G430C|PCDHA2_ENST00000526136.1_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGGGACGGGGGCTCGCCTTC	0.647000													9	64					3.09899e-07	3.43102e-07	1	1	0
ALMS1	7840	broad.mit.edu	37	2	73799684	73799684	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr2:73799684G>T	ENST00000264448.6	+	16	10788	c.10677G>T	c.(10675-10677)atG>atT	p.M3559I	ALMS1_ENST00000409009.1_Missense_Mutation_p.M3517I	NM_015120.4	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3559					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						AAGAAGTGATGGATACTACTA	0.383000													4	28					0.00024832	0.000260946	1	1	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29977342	29977342	+	RNA	SNP	A	A	T	rs116382006	by1000genomes	TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr6:29977342A>T	ENST00000376797.3	-	0	731				ZNRD1-AS1_ENST00000448093.1_RNA|HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA																							TGGGACTGAGAGGCAAGATTT	0.438000													3	49					0	0	1	0	0
ZNF425	155054	broad.mit.edu	37	7	148801692	148801692	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr7:148801692C>T	ENST00000378061.2	-	4	1403	c.1271G>A	c.(1270-1272)cGc>cAc	p.R424H		NM_001001661.2	NP_001001661.1	Q6IV72	ZN425_HUMAN	zinc finger protein 425	424					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	50	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			TCTCTTGAGGCGGAAACTTTT	0.552000													5	43					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49446697	49446697	+	Splice_Site	SNP	C	C	G			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr12:49446697C>G	ENST00000301067.7	-	8	1112		c.e8+1			NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		CCACCACTTACCTGCTACACA	0.537000													13	32					0	0	1	0	0
CBX6	23466	broad.mit.edu	37	22	39262385	39262385	+	Silent	SNP	C	C	A			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr22:39262385C>A	ENST00000407418.3	-	5	1191	c.1068G>T	c.(1066-1068)ggG>ggT	p.G356G	CBX6_ENST00000216083.6_Silent_p.G338G			O95503	CBX6_HUMAN	chromobox homolog 6	356					chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex				large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	6	Melanoma(58;0.04)					GGCGCCAGTCCCCAGCCTCGG	0.677000													5	31					0.014758	0.0149999	1	1	0
ZNF829	374899	broad.mit.edu	37	19	37383159	37383159	+	Silent	SNP	A	A	G			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr19:37383159A>G	ENST00000520965.1	-	6	843	c.777T>C	c.(775-777)caT>caC	p.H259H	ZNF345_ENST00000526123.1_Intron|ZNF345_ENST00000432005.2_Intron|ZNF829_ENST00000391711.3_Silent_p.H178H	NM_001171979.1	NP_001165450.1	Q3KNS6	ZN829_HUMAN	zinc finger protein 829	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(11)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	29	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTTCACCAAAATGAATTCTCT	0.378000													8	39					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13735963	13735963	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr5:13735963C>T	ENST00000265104.4	-	67	11638	c.11534G>A	c.(11533-11535)cGc>cAc	p.R3845H		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3845					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CAGAAACTGGCGAAGCGAAGT	0.468000									Kartagener syndrome				12	83					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176637121	176637122	+	Frame_Shift_Ins	INS	-	-	A			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr5:176637121_176637122insA	ENST00000439151.2	+	5	1766_1767	c.1721_1722insA	c.(1720-1725)ggaaaafs	p.GK574fs	NSD1_ENST00000347982.4_Frame_Shift_Ins_p.GK305fs|NSD1_ENST00000361032.4_Frame_Shift_Ins_p.GK471fs|NSD1_ENST00000354179.4_Frame_Shift_Ins_p.GK305fs	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	574					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TCTTCCTGTGGAAAAAACACTG	0.426			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			11	55	---	---	---	---					
TUSC1	286319	broad.mit.edu	37	9	25678133	25678133	+	Frame_Shift_Del	DEL	C	C	-			TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr9:25678133delC	ENST00000358022.3	-	1	723	c.187delG	c.(187-189)gagfs	p.E63fs		NM_001004125.2	NP_001004125.1	Q2TAM9	TUSC1_HUMAN	tumor suppressor candidate 1	63										kidney(1)	1	all_hematologic(1;0.197)	all_neural(3;5.42e-18)|Glioma(3;5.54e-17)		GBM - Glioblastoma multiforme(1;1.51e-108)|Lung(42;2.88e-14)|LUSC - Lung squamous cell carcinoma(38;3.16e-11)		GCAAACCGCTCCTCCAGCTGC	0.781													2	4	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7579581	7579582	+	Frame_Shift_Del	DEL	GC	GC	-	rs121912661		TCGA-XF-AAMJ-01A-11D-A42E-08	TCGA-XF-AAMJ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ddbcee4-305b-4803-9876-7d5a8ff4c4a2	35aead17-1960-44cb-90ec-61cf2326da35	g.chr17:7579581_7579582delGC	ENST00000420246.2	-	4	237_238	c.105_106delGC	c.(103-108)ttgccgfs	p.LP35fs	TP53_ENST00000455263.2_Frame_Shift_Del_p.LP35fs|TP53_ENST00000413465.2_Frame_Shift_Del_p.LP35fs|TP53_ENST00000359597.4_Frame_Shift_Del_p.LP35fs|TP53_ENST00000445888.2_Frame_Shift_Del_p.LP35fs|TP53_ENST00000269305.4_Frame_Shift_Del_p.LP35fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	35	Interaction with HRMT1L2.|Transcription activation (acidic).		L -> F (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.L35fs*8(4)|p.P36fs*4(3)|p.L35F(3)|p.?(1)|p.P13fs*18(1)|p.S33fs*6(1)|p.S33fs*23(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCTTGGGACGGCAAGGGGGACT	0.599		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			29	113	---	---	---	---					
