Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DIAPH2	1730	broad.mit.edu	37	X	96369882	96369882	+	Nonsense_Mutation	SNP	T	T	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chrX:96369882T>G	ENST00000324765.8	+	21	2854	c.2507T>G	c.(2506-2508)tTa>tGa	p.L836*	DIAPH2_ENST00000355827.4_Nonsense_Mutation_p.L836*|DIAPH2_ENST00000373061.3_Nonsense_Mutation_p.L836*|DIAPH2_ENST00000373054.4_Nonsense_Mutation_p.L832*|DIAPH2_ENST00000373049.4_Nonsense_Mutation_p.L836*			O60879	DIAP2_HUMAN	diaphanous-related formin 2	836	FH2.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51						CTTTTAGAGTTAGTTCTTCTT	0.353000													4	64					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169513703	169513703	+	Silent	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:169513703G>A	ENST00000367796.3	-	12	2022	c.1821C>T	c.(1819-1821)ttC>ttT	p.F607F	F5_ENST00000367797.3_Silent_p.F602F			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	602	F5/8 type A 2.|Plastocyanin-like 4.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CATCAAAGCAGAATCCAAGAG	0.428000													5	124					0	0	1	0	0
C20orf27	54976	broad.mit.edu	37	20	3735153	3735153	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr20:3735153C>A	ENST00000379772.3	-	5	1125	c.315G>T	c.(313-315)aaG>aaT	p.K105N	C20orf27_ENST00000217195.8_Missense_Mutation_p.K130N	NM_001258429.1	NP_001245358.1	Q9GZN8	CT027_HUMAN	chromosome 20 open reading frame 27	105										central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(4)|urinary_tract(1)	7						AGTACTCACACTTGACACTAT	0.642000													8	55					0.000274275	0.000289061	1	1	0
KIDINS220	57498	broad.mit.edu	37	2	8891728	8891728	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:8891728C>T	ENST00000256707.3	-	23	3239	c.3058G>A	c.(3058-3060)Gaa>Aaa	p.E1020K	KIDINS220_ENST00000427284.1_Missense_Mutation_p.E1020K|KIDINS220_ENST00000418530.1_Missense_Mutation_p.E978K|KIDINS220_ENST00000473731.1_Missense_Mutation_p.E1020K	NM_020738.2	NP_065789.1	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate, 220kDa	1020					activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane		p.E1020K(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(25)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	60	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CCATCAATTTCAAGAAGTGGC	0.323000													9	63					0	0	1	0	0
GNAQ	2776	broad.mit.edu	37	9	80343552	80343552	+	Missense_Mutation	SNP	C	C	G	rs2013373		TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr9:80343552C>G	ENST00000286548.4	-	6	989	c.767G>C	c.(766-768)aGa>aCa	p.R256T	GNAQ_ENST00000397476.3_Missense_Mutation_p.R54T	NM_002072.3	NP_002063.2	P50148	GNAQ_HUMAN	guanine nucleotide binding protein (G protein), q polypeptide	256					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|glutamate signaling pathway|negative regulation of protein kinase activity|platelet activation|protein ADP-ribosylation|protein stabilization|regulation of action potential|regulation of catenin import into nucleus	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activator activity|GTPase activity|signal transducer activity			NS(1)|endometrium(3)|eye(229)|kidney(1)|large_intestine(4)|lung(6)|meninges(11)|ovary(1)|prostate(1)|skin(44)|upper_aerodigestive_tract(1)	302						GATAATTGTTCTAAAGAGAGC	0.348000			Mis		uveal melanoma								15	125					0	0	1	0	0
SPP2	6694	broad.mit.edu	37	2	234959456	234959456	+	Missense_Mutation	SNP	C	C	T	rs145529777		TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:234959456C>T	ENST00000168148.3	+	1	114	c.26C>T	c.(25-27)aCg>aTg	p.T9M	SPP2_ENST00000373368.1_Missense_Mutation_p.T9M	NM_006944.2	NP_008875.1	Q13103	SPP24_HUMAN	secreted phosphoprotein 2, 24kDa	9					bone remodeling|skeletal system development	extracellular region	endopeptidase inhibitor activity			breast(1)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)	12		Breast(86;0.0109)|Renal(207;0.019)|all_lung(227;0.13)|all_hematologic(139;0.182)		Epithelial(121;5.73e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000166)|Lung(119;0.00539)|LUSC - Lung squamous cell carcinoma(224;0.00846)		GAGAAGATGACGATGATGATG	0.433000													6	75					0	0	1	0	0
TNFAIP6	7130	broad.mit.edu	37	2	152222693	152222693	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:152222693G>A	ENST00000243347.3	+	3	431	c.356G>A	c.(355-357)aGg>aAg	p.R119K		NM_007115.3	NP_009046.2	P98066	TSG6_HUMAN	tumor necrosis factor, alpha-induced protein 6	119	Link.				cell adhesion|cell-cell signaling|inflammatory response|signal transduction		hyaluronic acid binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.131)		CGTCTCAATAGGAGTGAAAGA	0.418000													5	61					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140175057	140175057	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr5:140175057T>C	ENST00000526136.1	+	1	508	c.508T>C	c.(508-510)Tac>Cac	p.Y170H	PCDHA2_ENST00000520672.2_Missense_Mutation_p.Y170H|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000378132.1_Missense_Mutation_p.Y170H|PCDHA1_ENST00000504120.2_Intron	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTTCTCTCCTACAAGCTCAG	0.453000													9	79					0	0	1	0	0
IL7R	3575	broad.mit.edu	37	5	35876212	35876212	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr5:35876212C>T	ENST00000303115.3	+	8	1133	c.1004C>T	c.(1003-1005)tCt>tTt	p.S335F	IL7R_ENST00000343305.4_3'UTR	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	335					immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			CTAGAAGAATCTGAGAAGCAG	0.478000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						4	43					0	0	1	0	0
NBEAL2	23218	broad.mit.edu	37	3	47049918	47049918	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:47049918G>A	ENST00000450053.3	+	51	8044	c.7865G>A	c.(7864-7866)cGt>cAt	p.R2622H	NBEAL2_ENST00000383740.2_Missense_Mutation_p.R871H|NBEAL2_ENST00000292309.5_Missense_Mutation_p.R2438H	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	2622							binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		GCGTGGGAACGTCCTGGGGCC	0.612000													7	37					0	0	1	0	0
DEPTOR	64798	broad.mit.edu	37	8	121013828	121013828	+	Silent	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr8:121013828G>A	ENST00000286234.5	+	5	799	c.669G>A	c.(667-669)cgG>cgA	p.R223R	DEPTOR_ENST00000518057.1_3'UTR|DEPTOR_ENST00000523492.1_Silent_p.R122R	NM_022783.2	NP_073620.2	Q8TB45	DPTOR_HUMAN	DEP domain containing MTOR-interacting protein	223	Poly-Arg.				intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	18						ACTTCCGGCGGAGGCGAAGAC	0.493000													9	54					0	0	1	0	0
ADRB1	153	broad.mit.edu	37	10	115804639	115804639	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr10:115804639G>A	ENST00000369295.2	+	1	834	c.748G>A	c.(748-750)Gag>Aag	p.E250K		NM_000684.2	NP_000675.1	P08588	ADRB1_HUMAN	adrenoceptor beta 1	250					positive regulation of cAMP biosynthetic process	integral to plasma membrane	alpha-2A adrenergic receptor binding|beta1-adrenergic receptor activity|protein heterodimerization activity			large_intestine(4)|lung(1)|upper_aerodigestive_tract(1)	6		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0124)|all cancers(201;0.0298)	Acebutolol(DB01193)|Alprenolol(DB00866)|Amiodarone(DB01118)|Arbutamine(DB01102)|Atenolol(DB00335)|Betaxolol(DB00195)|Bevantolol(DB01295)|Bisoprolol(DB00612)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Desipramine(DB01151)|Dobutamine(DB00841)|Dopamine(DB00988)|Epinephrine(DB00668)|Esmolol(DB00187)|Isoetharine(DB00221)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Metoprolol(DB00264)|Nadolol(DB01203)|Norepinephrine(DB00368)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Practolol(DB01297)|Propranolol(DB00571)|Risperidone(DB00734)|Timolol(DB00373)|Ziprasidone(DB00246)	GGTGTTCCGCGAGGCCCAGAA	0.692000													4	23					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72831193	72831193	+	Silent	SNP	G	G	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr16:72831193G>T	ENST00000268489.5	-	9	6060	c.5388C>A	c.(5386-5388)ctC>ctA	p.L1796L	ZFHX3_ENST00000397992.5_Silent_p.L882L	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	1796					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				AAGGGAAGAGGAGGTGCTGCT	0.582000													8	73					1.06961e-07	1.16172e-07	1	1	0
ZBTB41	360023	broad.mit.edu	37	1	197147643	197147643	+	Splice_Site	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:197147643C>T	ENST00000367405.4	-	6	1745		c.e6-1		ZBTB41_ENST00000467322.1_Splice_Site	NM_194314.2	NP_919290.2	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(11)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	40						CAAAGTAGTTCTGCATTAAAA	0.313000													9	19					0	0	1	0	0
LPAR4	2846	broad.mit.edu	37	X	78011238	78011238	+	Missense_Mutation	SNP	T	T	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chrX:78011238T>G	ENST00000435339.3	+	2	1258	c.872T>G	c.(871-873)aTc>aGc	p.I291S		NM_005296.2	NP_005287.1	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4							integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			breast(3)|endometrium(3)|kidney(4)|large_intestine(4)|lung(16)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	38						TTTGCAAAGATCATGTACCCA	0.418000													7	87					0	0	1	0	0
HNF4G	3174	broad.mit.edu	37	8	76465354	76465354	+	Silent	SNP	T	T	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr8:76465354T>C	ENST00000396423.2	+	5	661	c.537T>C	c.(535-537)tcT>tcC	p.S179S	HNF4G_ENST00000354370.1_Silent_p.S142S	NM_004133.4	NP_004124.4	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	142					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	37	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			TCTGTGAATCTATGAAACAGC	0.363000													4	43					0	0	1	0	0
ZNF154	7710	broad.mit.edu	37	19	58216284	58216284	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:58216284C>T	ENST00000512439.2	-	2	293	c.97G>A	c.(97-99)Gag>Aag	p.E33K	AC003006.7_ENST00000599221.1_Intron|AC003006.7_ENST00000594684.1_Intron|ZNF551_ENST00000596085.1_Intron|ZNF154_ENST00000426889.1_Missense_Mutation_p.E33K			Q13106	ZN154_HUMAN	zinc finger protein 154	33	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(3)	12		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CTTTGAGCCTCATCAAGGAGA	0.512000													20	89					0	0	1	0	0
YEATS2	55689	broad.mit.edu	37	3	183518262	183518262	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:183518262G>A	ENST00000305135.5	+	24	3529	c.3334G>A	c.(3334-3336)Gaa>Aaa	p.E1112K		NM_018023.4	NP_060493.3	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	1112					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			AGTGAAGACTGAACCAGAAAC	0.478000													5	55					0	0	1	0	0
CACNA2D1	781	broad.mit.edu	37	7	81799874	81799874	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr7:81799874C>A	ENST00000356860.3	-	4	684	c.346G>T	c.(346-348)Gat>Tat	p.D116Y	CACNA2D1_ENST00000423588.1_Missense_Mutation_p.D116Y|CACNA2D1_ENST00000356253.5_Missense_Mutation_p.D116Y	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1	116						voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	ACTGCAAAATCTTCTCTCCAC	0.333000													13	86					1.5842e-08	1.73995e-08	1	1	0
CPNE6	9362	broad.mit.edu	37	14	24546088	24546088	+	Splice_Site	SNP	A	A	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr14:24546088A>T	ENST00000397016.2	+	15	1477	c.1166A>T	c.(1165-1167)gAg>gTg	p.E389V	CPNE6_ENST00000216775.2_Splice_Site_p.E389V|CPNE6_ENST00000537691.1_Splice_Site_p.E444V	NM_001280558.1	NP_001267487.1	O95741	CPNE6_HUMAN	copine VI (neuronal)	389	VWFA.				lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			endometrium(4)|large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	22				GBM - Glioblastoma multiforme(265;0.0184)		TCACTCACAGAGATCTCAGGG	0.582000													3	39					0	0	1	0	0
RHBDD1	84236	broad.mit.edu	37	2	227732028	227732028	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:227732028C>A	ENST00000392062.2	+	5	1084	c.560C>A	c.(559-561)tCa>tAa	p.S187*	RHBDD1_ENST00000341329.3_Nonsense_Mutation_p.S187*	NM_001167608.1	NP_001161080.1	Q8TEB9	RHBD1_HUMAN	rhomboid domain containing 1	187						integral to membrane	serine-type endopeptidase activity			breast(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.023)|all_lung(227;0.13)|Esophageal squamous(248;0.23)|all_hematologic(139;0.248)		Epithelial(121;1.47e-11)|all cancers(144;1.52e-08)|Lung(261;0.0128)|LUSC - Lung squamous cell carcinoma(224;0.0175)		CATTTATTCTCACCAGGGTAA	0.393000													10	131					4.68919e-08	5.10717e-08	1	1	0
MYO9A	4649	broad.mit.edu	37	15	72324869	72324869	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr15:72324869G>C	ENST00000356056.5	-	3	1373	c.901C>G	c.(901-903)Caa>Gaa	p.Q301E	RP11-390D11.1_ENST00000568391.1_RNA|MYO9A_ENST00000564571.1_Missense_Mutation_p.Q301E|MYO9A_ENST00000566885.1_5'UTR|MYO9A_ENST00000563542.1_5'UTR|MYO9A_ENST00000444904.1_Missense_Mutation_p.Q301E|MYO9A_ENST00000424560.1_Missense_Mutation_p.Q301E	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	301	Myosin head-like 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						TAATTTACTTGAATAAACTTC	0.343000													6	35					0	0	1	0	0
C2orf66	401027	broad.mit.edu	37	2	197674106	197674106	+	Silent	SNP	G	G	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:197674106G>T	ENST00000342506.2	-	1	894	c.6C>A	c.(4-6)atC>atA	p.I2I		NM_213608.2	NP_998773.1	Q6UXQ4	CB066_HUMAN	chromosome 2 open reading frame 66	2						extracellular region				endometrium(2)|large_intestine(2)|lung(4)|ovary(1)	9						AGCTGTCAATGATCATTGAGA	0.473000													14	76					6.72482e-11	7.49119e-11	1	1	0
TTN	7273	broad.mit.edu	37	2	179417407	179417407	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:179417407C>A	ENST00000589042.1	-	335	90444	c.90220G>T	c.(90220-90222)Gaa>Taa	p.E30074*	TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342175.6_Nonsense_Mutation_p.E21201*|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Nonsense_Mutation_p.E27506*|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000359218.5_Nonsense_Mutation_p.E21134*|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000460472.2_Nonsense_Mutation_p.E21009*|TTN-AS1_ENST00000592600.1_RNA|TTN_ENST00000591111.1_Nonsense_Mutation_p.E28433*|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	28433	Fibronectin type-III 119.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACGTCTGTTCACCTTTACCT	0.448000													13	48					1.61879e-10	1.79815e-10	1	1	0
SLC7A10	56301	broad.mit.edu	37	19	33699809	33699809	+	Silent	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:33699809C>T	ENST00000253188.4	-	11	1706	c.1560G>A	c.(1558-1560)tcG>tcA	p.S520S		NM_019849.2	NP_062823.1	Q9NS82	AAA1_HUMAN	solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10						blood coagulation|cellular nitrogen compound metabolic process|ion transport|leukocyte migration	integral to plasma membrane	L-serine transmembrane transporter activity			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|stomach(1)	18	Esophageal squamous(110;0.137)					ATTGTGGCTTCGAGGGCTTGT	0.498000													3	15					0	0	1	0	0
PTBP1	5725	broad.mit.edu	37	19	804124	804124	+	Silent	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:804124C>T	ENST00000356948.6	+	4	627	c.204C>T	c.(202-204)atC>atT	p.I68I	PTBP1_ENST00000394601.4_Silent_p.I68I|PTBP1_ENST00000350092.4_Intron|PTBP1_ENST00000349038.4_Silent_p.I68I	NM_002819.4	NP_002810.1	P26599	PTBP1_HUMAN	polypyrimidine tract binding protein 1	68	RRM 1.				negative regulation of muscle cell differentiation|nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	mRNA binding|nucleotide binding|poly-pyrimidine tract binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(4)	19		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCTCCCCATCGACGTCACGG	0.572000													4	39					0	0	1	0	0
PHKA1	5255	broad.mit.edu	37	X	71800983	71800983	+	Missense_Mutation	SNP	C	C	T	rs140865522	byFrequency	TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chrX:71800983C>T	ENST00000373545.3	-	32	3853	c.3415G>A	c.(3415-3417)Gca>Aca	p.A1139T	PHKA1_ENST00000373539.3_Missense_Mutation_p.A1198T|PHKA1_ENST00000373542.4_Missense_Mutation_p.A1181T|PHKA1_ENST00000339490.3_Missense_Mutation_p.A1168T|PHKA1_ENST00000541944.1_Missense_Mutation_p.A1109T			P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle)	1181					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(2)|lung(18)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	52	Renal(35;0.156)					ATGCCAGATGCGGGATCCTTT	0.488000													6	32					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168830631	168830631	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:168830631C>G	ENST00000464456.1	-	8	3157	c.1957G>C	c.(1957-1959)Gaa>Caa	p.E653Q	MECOM_ENST00000264674.3_Missense_Mutation_p.E718Q|MECOM_ENST00000433243.2_Missense_Mutation_p.E654Q|MECOM_ENST00000468789.1_Missense_Mutation_p.E653Q|MECOM_ENST00000460814.1_Missense_Mutation_p.E653Q|MECOM_ENST00000392736.3_Missense_Mutation_p.E653Q|MECOM_ENST00000472280.1_Missense_Mutation_p.E654Q|MECOM_ENST00000494292.1_Missense_Mutation_p.E841Q	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						TTTAAAGCTTCAAGTGGGTCA	0.353000													6	78					0	0	1	0	0
HMHA1	23526	broad.mit.edu	37	19	1085775	1085775	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:1085775G>A	ENST00000313093.2	+	23	3412	c.3181G>A	c.(3181-3183)Gag>Aag	p.E1061K	HMHA1_ENST00000591169.1_3'UTR|HMHA1_ENST00000536472.1_Missense_Mutation_p.E929K|HMHA1_ENST00000543365.1_Missense_Mutation_p.E944K|HMHA1_ENST00000590214.1_Missense_Mutation_p.E1088K|HMHA1_ENST00000539243.2_Missense_Mutation_p.E1077K|HMHA1_ENST00000590577.1_Missense_Mutation_p.E696K|HMHA1_ENST00000586866.1_Missense_Mutation_p.E1065K	NM_012292.3	NP_036424.2	Q92619	HMHA1_HUMAN	histocompatibility (minor) HA-1	1061					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(7)|ovary(1)|prostate(2)	16		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCAGCAGAGCGAGGCCAGCCT	0.692000													3	22					0	0	1	0	0
WDR96	80217	broad.mit.edu	37	10	105963513	105963513	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr10:105963513C>T	ENST00000357060.3	-	8	1127	c.1012G>A	c.(1012-1014)Gag>Aag	p.E338K	WDR96_ENST00000369720.1_Missense_Mutation_p.E269K|WDR96_ENST00000369719.1_Missense_Mutation_p.E269K|WDR96_ENST00000428666.1_Missense_Mutation_p.E339K|WDR96_ENST00000278064.2_Missense_Mutation_p.E269K	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	338										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						AGAAAATCCTCGATCATGTAA	0.328000													12	24					0	0	1	0	0
FOSB	2354	broad.mit.edu	37	19	45973911	45973911	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:45973911C>T	ENST00000353609.3	+	2	743	c.151C>T	c.(151-153)Ccc>Tcc	p.P51S	ERCC1_ENST00000423698.2_Intron|FOSB_ENST00000590335.1_Missense_Mutation_p.P51S|FOSB_ENST00000591858.1_Intron|FOSB_ENST00000417353.2_Missense_Mutation_p.P51S|FOSB_ENST00000586615.1_Missense_Mutation_p.P2S|FOSB_ENST00000585836.1_Intron|FOSB_ENST00000592811.1_Missense_Mutation_p.P2S|FOSB_ENST00000592436.1_Missense_Mutation_p.P51S|FOSB_ENST00000443841.2_Intron	NM_006732.2	NP_006723.2	P53539	FOSB_HUMAN	FBJ murine osteosarcoma viral oncogene homolog B	51					behavior|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|pancreas(1)	13		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00814)|Epithelial(262;0.18)|GBM - Glioblastoma multiforme(486;0.242)		CGGGGAAATGCCCGGTTCCTT	0.592000													4	131					0	0	1	0	0
ZSCAN22	342945	broad.mit.edu	37	19	58849961	58849961	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:58849961G>C	ENST00000329665.4	+	3	892	c.745G>C	c.(745-747)Gat>Cat	p.D249H		NM_181846.2	NP_862829.1	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	249					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|pancreas(1)|prostate(2)	16		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		AGACAAATTTGATCTGGTGGA	0.542000													20	136					0	0	1	0	0
MEA1	4201	broad.mit.edu	37	6	42980715	42980715	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr6:42980715C>A	ENST00000244711.3	-	3	509	c.355G>T	c.(355-357)Gag>Tag	p.E119*		NM_014623.2	NP_055438.1	Q16626	MEA1_HUMAN	male-enhanced antigen 1	119					cell differentiation|male gonad development|spermatogenesis		protein binding			central_nervous_system(1)|large_intestine(3)|lung(1)|skin(1)	6			Colorectal(64;0.00237)|all cancers(41;0.00411)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0664)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GCTCCCTCCTCATCTTCATCT	0.488000													9	70					0.00829132	0.00844246	1	1	0
NEUROD6	63974	broad.mit.edu	37	7	31378020	31378020	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr7:31378020C>T	ENST00000297142.3	-	2	1185	c.863G>A	c.(862-864)gGc>gAc	p.G288D		NM_022728.2	NP_073565.2	Q96NK8	NDF6_HUMAN	neuronal differentiation 6	288					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.G288V(1)		breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	32						GTAATGCATGCCGTAATTGTA	0.493000													23	50					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183713484	183713484	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr4:183713484G>C	ENST00000511685.1	+	26	5782	c.5659G>C	c.(5659-5661)Gac>Cac	p.D1887H	TENM3_ENST00000406950.2_Missense_Mutation_p.D1887H					teneurin transmembrane protein 3																		CGATATGTGGGACCGCCTGTC	0.517000													5	57					0	0	1	0	0
PCDHGA12	26025	broad.mit.edu	37	5	140811520	140811520	+	Silent	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr5:140811520C>T	ENST00000252085.3	+	1	1336	c.1194C>T	c.(1192-1194)taC>taT	p.Y398Y	PCDHGA11_ENST00000518882.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_003735.2|NM_032094.1	NP_003726.1|NP_115265.1														breast(2)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(23)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	58			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAAAATCTTACGGAAATTACT	0.428000													10	57					0	0	1	0	0
PDIA5	10954	broad.mit.edu	37	3	122808040	122808040	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:122808040C>T	ENST00000316218.7	+	2	163	c.68C>T	c.(67-69)tCt>tTt	p.S23F		NM_006810.3	NP_006801.1	Q14554	PDIA5_HUMAN	protein disulfide isomerase family A, member 5	23					cell redox homeostasis|glycerol ether metabolic process|protein folding|response to stress	endoplasmic reticulum lumen	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			breast(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	21				GBM - Glioblastoma multiforme(114;0.0427)		TGGCTGTCCTCTGCAAAGGTC	0.522000													5	53					0	0	1	0	0
ZNF177	7730	broad.mit.edu	37	19	9492324	9492324	+	Silent	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:9492324G>C	ENST00000541595.2	+	12	1466	c.837G>C	c.(835-837)ctG>ctC	p.L279L	ZNF177_ENST00000446085.4_3'UTR|ZNF177_ENST00000343499.4_Silent_p.L279L|ZNF177_ENST00000434737.2_Silent_p.L439L|ZNF177_ENST00000589262.1_Silent_p.L439L|ZNF177_ENST00000590616.1_Intron|ZNF177_ENST00000602856.1_3'UTR|ZNF177_ENST00000602738.1_Silent_p.L279L	NM_001172650.2	NP_001166121.1	Q13360	ZN177_HUMAN	zinc finger protein 177	279					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|stomach(2)	13						CCTCTTGCCTGAGGGTACACG	0.433000													20	128					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19477075	19477075	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:19477075C>G	ENST00000375267.2	-	49	7429	c.7426G>C	c.(7426-7428)Gag>Cag	p.E2476Q	UBR4_ENST00000375254.3_Missense_Mutation_p.E2476Q|UBR4_ENST00000375226.2_Missense_Mutation_p.E2476Q|UBR4_ENST00000375217.2_Missense_Mutation_p.E2476Q			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	2476					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding	p.E2476Q(1)		breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TGGTACCTCTCCAGGACAGTT	0.522000													17	84					0	0	1	0	0
GAK	2580	broad.mit.edu	37	4	861181	861181	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr4:861181G>A	ENST00000314167.4	-	21	2545	c.2435C>T	c.(2434-2436)tCc>tTc	p.S812F	GAK_ENST00000509566.1_5'UTR|GAK_ENST00000511163.1_Missense_Mutation_p.S733F	NM_005255.2	NP_005246.2	O14976	GAK_HUMAN	cyclin G associated kinase	812					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(16)|skin(7)|urinary_tract(2)	39				Colorectal(103;0.219)		GCTCTCCTTGGAAGAGGCATT	0.587000													4	49					0	0	1	0	0
KLF6	1316	broad.mit.edu	37	10	3824197	3824197	+	Silent	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr10:3824197C>T	ENST00000497571.1	-	2	572	c.312G>A	c.(310-312)ctG>ctA	p.L104L	KLF6_ENST00000173785.4_5'UTR|KLF6_ENST00000542957.1_Silent_p.L104L|KLF6_ENST00000469435.1_Silent_p.L104L	NM_001160124.1|NM_001300.5	NP_001153596.1|NP_001291.3	Q99612	KLF6_HUMAN	Kruppel-like factor 6	104					B cell differentiation	nucleus	zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(1)|large_intestine(1)|lung(6)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				Colorectal(1;0.238)		CATCTGAGTTCAGGCTGTTGG	0.517000											OREG0019980	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	234					0	0	1	0	0
CEP170	9859	broad.mit.edu	37	1	243349355	243349355	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:243349355C>T	ENST00000366542.1	-	10	1343	c.1292G>A	c.(1291-1293)aGa>aAa	p.R431K	CEP170_ENST00000366544.1_Intron|CEP170_ENST00000366543.1_Intron	NM_014812.2	NP_055627.2	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa	431						centriole|microtubule|spindle				NS(1)|breast(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	62	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			ATGCCCCCCTCTGTGATGCGC	0.423000													9	22					0	0	1	0	0
ZNF197	10168	broad.mit.edu	37	3	44685051	44685051	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:44685051G>C	ENST00000396058.1	+	5	2596	c.2429G>C	c.(2428-2430)aGa>aCa	p.R810T	RP11-944L7.4_ENST00000457331.1_RNA|ZNF197_ENST00000383745.2_Intron|ZNF197_ENST00000344387.4_Missense_Mutation_p.R810T|ZNF197_ENST00000383744.4_Intron			O14709	ZN197_HUMAN	zinc finger protein 197	810					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(1)	25				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		GGACATCAGAGAATTCACACG	0.433000													8	85					0	0	1	0	0
MCM10	55388	broad.mit.edu	37	10	13213041	13213041	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr10:13213041G>C	ENST00000378694.1	+	2	202	c.127G>C	c.(127-129)Gat>Cat	p.D43H	MCM10_ENST00000484800.2_Missense_Mutation_p.D43H|MCM10_ENST00000378714.3_Missense_Mutation_p.D43H			Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	43					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			central_nervous_system(1)|large_intestine(4)|ovary(2)|skin(1)|stomach(1)	9						CGACGCATTTGATGAGCTCTT	0.478000													35	226					0	0	1	0	0
HDAC6	10013	broad.mit.edu	37	X	48678570	48678570	+	Silent	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chrX:48678570C>T	ENST00000334136.5	+	23	2423	c.2245C>T	c.(2245-2247)Ctg>Ttg	p.L749L	HDAC6_ENST00000376619.2_Silent_p.L749L|HDAC6_ENST00000444343.2_Silent_p.L763L			Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	749	Histone deacetylase 2.				aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(8)|lung(9)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	40					Vorinostat(DB02546)	GGGGGATCCGCTGGGGGGCTG	0.572000													10	55					0	0	1	0	0
NEFM	4741	broad.mit.edu	37	8	24771450	24771450	+	Silent	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr8:24771450G>A	ENST00000221166.5	+	1	926	c.144G>A	c.(142-144)gtG>gtA	p.V48V	GS1-72M22.1_ENST00000607058.1_RNA|NEFM_ENST00000437366.2_Silent_p.V48V|NEFM_ENST00000518131.1_Silent_p.V48V|NEFM_ENST00000521540.1_3'UTR			P07197	NFM_HUMAN	neurofilament, medium polypeptide	48	Head.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(3)|endometrium(7)|kidney(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|urinary_tract(1)	36		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		CCAGCACCGTGTCCTCCTCCT	0.687000													6	24					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91731955	91731955	+	Silent	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr7:91731955C>T	ENST00000359028.2	+	46	11382	c.11157C>T	c.(11155-11157)ctC>ctT	p.L3719L	AKAP9_ENST00000356239.3_Silent_p.L3715L|AKAP9_ENST00000358100.2_Silent_p.L3665L			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	3719					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GAAAGGCTCTCATTTACCAGA	0.458000			T	BRAF	papillary thyroid								16	48					0	0	1	0	0
ESRRG	2104	broad.mit.edu	37	1	216850770	216850770	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:216850770C>G	ENST00000391890.3	-	4	568	c.51G>C	c.(49-51)aaG>aaC	p.K17N	ESRRG_ENST00000366938.2_Missense_Mutation_p.K17N|ESRRG_ENST00000487276.1_Missense_Mutation_p.K17N|ESRRG_ENST00000366940.2_Missense_Mutation_p.K17N|ESRRG_ENST00000463665.1_Missense_Mutation_p.K17N|ESRRG_ENST00000493603.1_Missense_Mutation_p.K17N|ESRRG_ENST00000360012.3_Missense_Mutation_p.K17N|ESRRG_ENST00000493748.1_Missense_Mutation_p.K17N|ESRRG_ENST00000366937.1_Missense_Mutation_p.K45N|ESRRG_ENST00000361525.3_Missense_Mutation_p.K17N|ESRRG_ENST00000361395.2_Missense_Mutation_p.K17N|ESRRG_ENST00000408911.3_Missense_Mutation_p.K40N|ESRRG_ENST00000359162.2_Missense_Mutation_p.K17N	NM_001243515.1|NM_001243519.1	NP_001230444.1|NP_001230448.1	P62508	ERR3_HUMAN	estrogen-related receptor gamma	40					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(8)|liver(1)|lung(29)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	AAGGTTCCGTCTTGATGAAGG	0.517000													13	17					0	0	1	0	0
MIB1	57534	broad.mit.edu	37	18	19395622	19395622	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr18:19395622G>A	ENST00000261537.6	+	11	1789	c.1525G>A	c.(1525-1527)Gaa>Aaa	p.E509K	MIB1_ENST00000578646.1_3'UTR	NM_020774.2	NP_065825.1	Q86YT6	MIB1_HUMAN	mindbomb E3 ubiquitin protein ligase 1	509					Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|ovary(5)	27			STAD - Stomach adenocarcinoma(5;0.212)			TTTTGGAGATGAAGGCGCTGT	0.378000													6	38					0	0	1	0	0
SEZ6	124925	broad.mit.edu	37	17	27284533	27284533	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr17:27284533T>C	ENST00000317338.12	-	12	2755	c.2327A>G	c.(2326-2328)gAt>gGt	p.D776G	SEZ6_ENST00000335960.6_Intron|SEZ6_ENST00000442608.3_Missense_Mutation_p.D776G|SEZ6_ENST00000360295.9_Missense_Mutation_p.D776G|PIPOX_ENST00000583215.1_Intron			Q53EL9	SEZ6_HUMAN	seizure related 6 homolog (mouse)	776	Sushi 4.					integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(4)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	29	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			GTGCTCCACATCTCCAGGATC	0.572000													3	19					0	0	1	0	0
FGF19	9965	broad.mit.edu	37	11	69514275	69514275	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr11:69514275A>G	ENST00000294312.3	-	3	1171	c.406T>C	c.(406-408)Tcc>Ccc	p.S136P		NM_005117.2	NP_005108.1	O95750	FGF19_HUMAN	fibroblast growth factor 19	136					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of bile acid biosynthetic process|nervous system development|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of glucose import|positive regulation of JNK cascade	extracellular region	fibroblast growth factor receptor binding|growth factor activity			large_intestine(2)|lung(2)|skin(2)	6	all_cancers(3;5.53e-114)|all_epithelial(3;1.34e-121)|Breast(3;9.28e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;6.15e-15)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;3.05e-56)|all cancers(3;2.69e-50)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)			TGCTTCTCGGATCGGTACACA	0.552000													8	919					0	0	1	0	0
MTL5	9633	broad.mit.edu	37	11	68483325	68483325	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr11:68483325C>T	ENST00000255087.5	-	7	1183	c.1000G>A	c.(1000-1002)Gaa>Aaa	p.E334K		NM_004923.3	NP_004914.2	Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific (tesmin)	334					cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)	15	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)			TTAAACCGTTCAATATCATGA	0.353000													31	361					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32624119	32624119	+	Silent	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr21:32624119C>T	ENST00000286827.3	-	6	1821	c.1350G>A	c.(1348-1350)aaG>aaA	p.K450K	TIAM1_ENST00000541036.1_Silent_p.K450K|TIAM1_ENST00000469412.1_5'UTR	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	450	PH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						CCTTCTTGTTCTTCTTGTGCA	0.637000													6	65					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559207	140559207	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr5:140559207G>A	ENST00000239444.2	+	1	1837	c.1592G>A	c.(1591-1593)cGg>cAg	p.R531Q		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		531	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.R531Q(1)		NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCGAGTTCCGGGTGGGCGCT	0.672000													15	82					0	0	1	0	0
TOR1B	27348	broad.mit.edu	37	9	132565547	132565547	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr9:132565547C>T	ENST00000259339.2	+	1	116	c.56C>T	c.(55-57)gCc>gTc	p.A19V	TOR1B_ENST00000486372.1_3'UTR	NM_014506.1	NP_055321.1	O14657	TOR1B_HUMAN	torsin family 1, member B (torsin B)	19					chaperone mediated protein folding requiring cofactor|response to unfolded protein	endoplasmic reticulum lumen	ATP binding|nucleoside-triphosphatase activity|unfolded protein binding			endometrium(3)|kidney(1)|large_intestine(1)|lung(7)	12		Ovarian(14;0.0586)				CTGCTGGCGGCCCGAGTGGTG	0.726000													4	9					0	0	1	0	0
RIF1	55183	broad.mit.edu	37	2	152324596	152324596	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:152324596C>A	ENST00000243326.5	+	30	7166	c.6683C>A	c.(6682-6684)tCc>tAc	p.S2228Y	RIF1_ENST00000430328.2_Missense_Mutation_p.S2228Y|RIF1_ENST00000428287.2_Missense_Mutation_p.S2228Y|RIF1_ENST00000444746.2_Missense_Mutation_p.S2228Y|RIF1_ENST00000453091.2_Missense_Mutation_p.S2228Y			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)		Interaction with condensed chromosomes in telophase.				cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		ATTGTTAGGTCCCATTCTTCC	0.393000													8	66					0.000157383	0.000166767	1	1	0
H6PD	9563	broad.mit.edu	37	1	9323957	9323957	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:9323957C>T	ENST00000377403.2	+	5	1707	c.1405C>T	c.(1405-1407)Cgg>Tgg	p.R469W	H6PD_ENST00000602477.1_Missense_Mutation_p.R480W	NM_001282587.1|NM_004285.3	NP_001269516.1|NP_004276.2	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	469	Glucose 1-dehydrogenase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)	CTTCCATGGCCGGAAGAATTT	0.602000													11	103					0	0	1	0	0
ZC3H7B	23264	broad.mit.edu	37	22	41739487	41739487	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr22:41739487G>A	ENST00000352645.4	+	13	1623	c.1366G>A	c.(1366-1368)Ggc>Agc	p.G456S	ZC3H7B_ENST00000351589.4_Missense_Mutation_p.G456S	NM_017590.4	NP_060060.3	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	472					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						CATCCTGCTCGGCCGGCTCCG	0.642000													4	44					0	0	1	0	0
RBM43	375287	broad.mit.edu	37	2	152107755	152107755	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:152107755G>C	ENST00000331426.5	-	4	890	c.739C>G	c.(739-741)Ctg>Gtg	p.L247V		NM_198557.2	NP_940959.1	Q6ZSC3	RBM43_HUMAN	RNA binding motif protein 43	247							nucleotide binding|RNA binding			endometrium(2)|large_intestine(3)|lung(2)|ovary(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.131)		TCCTGACTCAGAATGTGGAAT	0.378000													5	64					0	0	1	0	0
OTOL1	131149	broad.mit.edu	37	3	161214869	161214869	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:161214869C>G	ENST00000327928.4	+	1	274	c.274C>G	c.(274-276)Ctt>Gtt	p.L92V		NM_001080440.1	NP_001073909.1	A6NHN0	OTOL1_HUMAN	otolin 1	92						collagen				central_nervous_system(2)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)	27						AAACTTCACTCTTGACCCAGC	0.463000													4	93					0	0	1	0	0
CCDC96	257236	broad.mit.edu	37	4	7043426	7043426	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr4:7043426C>A	ENST00000310085.4	-	1	1302	c.1240G>T	c.(1240-1242)Gag>Tag	p.E414*	RP11-367J11.2_ENST00000500031.1_RNA	NM_153376.2	NP_699207.1	Q2M329	CCD96_HUMAN	coiled-coil domain containing 96	414										endometrium(3)|kidney(1)|large_intestine(3)|lung(2)|skin(1)|urinary_tract(1)	11						GTTTGGTTCTCAATCTTCAGC	0.453000													24	95					1.22574e-08	1.35385e-08	1	1	0
USP9X	8239	broad.mit.edu	37	X	41060386	41060386	+	Silent	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chrX:41060386G>C	ENST00000324545.8	+	31	5310	c.4677G>C	c.(4675-4677)ctG>ctC	p.L1559L	USP9X_ENST00000378308.2_Silent_p.L1559L	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked						BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity	p.L1552L(1)		NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						TCGTGGGGCTGAAAAATGCCG	0.468000													5	58					0	0	1	0	0
GOLGA1	2800	broad.mit.edu	37	9	127650667	127650667	+	Silent	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr9:127650667C>G	ENST00000373555.4	-	19	2103	c.1770G>C	c.(1768-1770)tcG>tcC	p.S590S		NM_002077.3	NP_002068	Q92805	GOGA1_HUMAN	golgin A1	590						Golgi cisterna membrane				NS(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|stomach(1)	20						GCATGGCCCTCGAGGTCACCT	0.557000													20	44					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40084466	40084466	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr20:40084466C>G	ENST00000373233.3	-	19	3160	c.2983G>C	c.(2983-2985)Gag>Cag	p.E995Q	CHD6_ENST00000309279.7_Intron	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	995					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				CCTTTCCCCTCAGACTGGATG	0.483000													20	257					0	0	1	0	0
PPIG	9360	broad.mit.edu	37	2	170493929	170493929	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:170493929G>C	ENST00000260970.3	+	14	2381	c.2161G>C	c.(2161-2163)Gaa>Caa	p.E721Q	PPIG_ENST00000409714.3_Missense_Mutation_p.E706Q|PPIG_ENST00000448752.2_Missense_Mutation_p.E721Q	NM_004792.2	NP_004783.2	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G (cyclophilin G)	721					protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(17)|ovary(2)|stomach(1)|urinary_tract(1)	43					L-Proline(DB00172)	AGTGGAAAAAGAAAACCAAAA	0.343000													8	44					0	0	1	0	0
CACNA1F	778	broad.mit.edu	37	X	49070723	49070723	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chrX:49070723C>G	ENST00000376265.2	-	30	3698	c.3637G>C	c.(3637-3639)Gag>Cag	p.E1213Q	CACNA1F_ENST00000323022.5_Missense_Mutation_p.E1202Q|CACNA1F_ENST00000376251.1_Missense_Mutation_p.E1148Q	NM_005183.2	NP_005174.2	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type, alpha 1F subunit	1213					axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(8)|central_nervous_system(3)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(4)|urinary_tract(1)	85					Verapamil(DB00661)	GCAGTCTGCTCATAGTGCTGC	0.532000													10	47					0	0	1	0	0
MAMSTR	284358	broad.mit.edu	37	19	49216635	49216635	+	Silent	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:49216635C>G	ENST00000318083.6	-	10	1200	c.1137G>C	c.(1135-1137)ctG>ctC	p.L379L	MAMSTR_ENST00000594582.1_Silent_p.L211L|MAMSTR_ENST00000356751.4_Silent_p.L276L|MAMSTR_ENST00000377367.3_Silent_p.L211L|MAMSTR_ENST00000419611.1_Silent_p.L276L			Q6ZN01	MASTR_HUMAN	MEF2 activating motif and SAP domain containing transcriptional regulator	379	Pro-rich.|Ser-rich.|Transcription activation (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(1)|ovary(1)	2						GACCCCCGCTCAGGGCCTCCA	0.647000											OREG0025608	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	29					0	0	1	0	0
TCF25	22980	broad.mit.edu	37	16	89965217	89965217	+	Silent	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr16:89965217C>T	ENST00000263346.8	+	11	1214	c.1158C>T	c.(1156-1158)atC>atT	p.I386I	TCF25_ENST00000263347.7_Silent_p.I151I	NM_014972.2	NP_055787.1	Q9BQ70	TCF25_HUMAN	transcription factor 25 (basic helix-loop-helix)	386					heart development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|large_intestine(1)|lung(8)|ovary(3)|skin(1)|urinary_tract(2)	18		all_cancers(9;4.71e-08)|Lung NSC(15;0.000192)|all_lung(18;0.000319)|all_neural(9;0.0122)|all_hematologic(23;0.027)		BRCA - Breast invasive adenocarcinoma(80;0.0288)		TGCTGCTCATCGACCACCTGG	0.657000													8	34					0	0	1	0	0
TNS1	7145	broad.mit.edu	37	2	218745672	218745672	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:218745672G>A	ENST00000171887.4	-	16	1455	c.1003C>T	c.(1003-1005)Cgc>Tgc	p.R335C	TNS1_ENST00000430930.1_Missense_Mutation_p.R335C|TNS1_ENST00000419504.1_Missense_Mutation_p.R335C|TNS1_ENST00000310858.6_Missense_Mutation_p.R366C	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	335						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GAGTCCCAGCGGATGAGGGGG	0.612000													5	35					0	0	1	0	0
NBPF14	25832	broad.mit.edu	37	1	148008607	148008607	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:148008607C>T	ENST00000369219.1	-	17	1997	c.1981G>A	c.(1981-1983)Gaa>Aaa	p.E661K				Q5TI25	NBPFE_HUMAN	neuroblastoma breakpoint family, member 14	661	NBPF 7.					cytoplasm				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(23)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	42	all_hematologic(923;0.032)					TCTTCCACTTCTTGGTACTTT	0.428000													23	529					0	0	1	0	0
PNLIPRP3	119548	broad.mit.edu	37	10	118225615	118225615	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr10:118225615G>T	ENST00000369230.3	+	8	1008	c.862G>T	c.(862-864)Gaa>Taa	p.E288*		NM_001011709.2	NP_001011709.2	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3	288					lipid catabolic process	extracellular region	triglyceride lipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(29)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50				all cancers(201;0.0131)		ATTTTATGCTGAAAGCATTCT	0.318000													7	63					0.00307968	0.00317719	1	1	0
MARK1	4139	broad.mit.edu	37	1	220835326	220835326	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:220835326G>C	ENST00000402574.1	+	17	2758	c.1756G>C	c.(1756-1758)Gag>Cag	p.E586Q	MARK1_ENST00000366917.4_Missense_Mutation_p.E736Q|MARK1_ENST00000366918.4_Missense_Mutation_p.E699Q	NM_018650.3	NP_061120.3	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	736					intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(2)|endometrium(9)|kidney(6)|large_intestine(12)|lung(22)|ovary(4)|pancreas(1)|skin(3)|stomach(3)|urinary_tract(1)	63				GBM - Glioblastoma multiforme(131;0.0407)		TGAGCAAAAAGAGAGATTTTT	0.433000													5	75					0	0	1	0	0
RFX7	64864	broad.mit.edu	37	15	56388201	56388201	+	Silent	SNP	T	T	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr15:56388201T>A	ENST00000423270.1	-	9	1724	c.1725A>T	c.(1723-1725)acA>acT	p.T575T	RFX7_ENST00000559447.2_Silent_p.T478T|RFX7_ENST00000422057.1_Silent_p.T478T|RFX7_ENST00000317318.6_Silent_p.T575T	NM_022841.5	NP_073752.5	Q2KHR2	RFX7_HUMAN	regulatory factor X, 7	478					regulation of transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						GTGCTCCGTCTGTATTACTTT	0.438000													3	27					0	0	1	0	0
ZNF236	7776	broad.mit.edu	37	18	74637250	74637250	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr18:74637250C>T	ENST00000253159.8	+	22	3959	c.3761C>T	c.(3760-3762)cCg>cTg	p.P1254L	ZNF236_ENST00000320610.9_Missense_Mutation_p.P1256L	NM_007345.3	NP_031371.3	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1254					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		TTCAAATGCCCGCATTGCGAG	0.532000													5	42					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107049681	107049681	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:107049681T>C	ENST00000409886.3	-	16	2353	c.2266A>G	c.(2266-2268)Aac>Gac	p.N756D	RGPD3_ENST00000304514.7_Missense_Mutation_p.N756D	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	756					intracellular transport		binding	p.N756D(6)		breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						TCACTATAGTTTTCGAGTTCC	0.373000													4	424					0	0	1	0	0
DCP1B	196513	broad.mit.edu	37	12	2061975	2061975	+	Silent	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr12:2061975G>C	ENST00000280665.6	-	7	1210	c.1131C>G	c.(1129-1131)gcC>gcG	p.A377A	DCP1B_ENST00000397173.4_Silent_p.A275A|DCP1B_ENST00000540622.1_Silent_p.A251A|DCP1B_ENST00000541700.1_5'UTR	NM_152640.3	NP_689853.3	Q8IZD4	DCP1B_HUMAN	decapping mRNA 1B	377					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(10)|skin(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			CAGCTGAGCTGGCAGGTGCTG	0.557000													14	55					0	0	1	0	0
OR6F1	343169	broad.mit.edu	37	1	247875357	247875357	+	Missense_Mutation	SNP	C	C	A	rs138204394		TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:247875357C>A	ENST00000302084.2	-	1	748	c.701G>T	c.(700-702)cGg>cTg	p.R234L	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005286.1	NP_001005286.1	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F, member 1	234					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(5)|lung(34)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)	47	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GGCTTTGCTCCGGCCACTGGC	0.527000													12	78					1.41608e-15	1.59564e-15	1	1	0
TBC1D10A	83874	broad.mit.edu	37	22	30722780	30722780	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr22:30722780C>G	ENST00000215790.7	-	1	255	c.91G>C	c.(91-93)Gac>Cac	p.D31H	TBC1D10A_ENST00000490449.1_5'UTR|TBC1D10A_ENST00000403477.3_Missense_Mutation_p.D31H	NM_031937.2	NP_114143.1	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	31						intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	23						GTTGCGGCGTCGGGGCCCTGG	0.706000													3	20					0	0	1	0	0
SCGB2A1	4246	broad.mit.edu	37	11	61978051	61978051	+	Silent	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr11:61978051G>C	ENST00000244930.4	+	2	286	c.222G>C	c.(220-222)ctG>ctC	p.L74L		NM_002407.2	NP_002398.1	O75556	SG2A1_HUMAN	secretoglobin, family 2A, member 1	74						extracellular region	androgen binding			breast(1)|kidney(1)|large_intestine(2)|lung(2)	6						ATAGAACTCTGAAAAACTTTG	0.418000													9	79					0	0	1	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156906710	156906710	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:156906710C>T	ENST00000368194.3	-	40	5567	c.4528G>A	c.(4528-4530)Gaa>Aaa	p.E1510K	ARHGEF11_ENST00000315174.8_Missense_Mutation_p.E886K|ARHGEF11_ENST00000487682.1_5'UTR|ARHGEF11_ENST00000361409.2_Missense_Mutation_p.E1470K	NM_198236.2	NP_937879.1	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	1470					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(27)|ovary(4)|pancreas(2)|pleura(1)|prostate(4)|skin(7)|stomach(1)|urinary_tract(2)	81	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CTAGCTGCTTCTGTGTGGAAA	0.602000													7	66					0	0	1	0	0
KHDRBS1	10657	broad.mit.edu	37	1	32503557	32503557	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:32503557C>G	ENST00000327300.7	+	6	1194	c.1027C>G	c.(1027-1029)Cca>Gca	p.P343A	KHDRBS1_ENST00000307714.8_3'UTR|KHDRBS1_ENST00000492989.1_Missense_Mutation_p.P304A	NM_006559.1	NP_006550.1	Q07666	KHDR1_HUMAN	KH domain containing, RNA binding, signal transduction associated 1	343	Pro-rich.				cell cycle arrest|cell proliferation|cell surface receptor linked signaling pathway|G2/M transition of mitotic cell cycle|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of RNA export from nucleus|transcription, DNA-dependent	membrane|nucleus	DNA binding|RNA binding|SH3 domain binding|SH3/SH2 adaptor activity			endometrium(4)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)	14		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GAGGGGTGCTCCAGCACCAAG	0.552000													9	73					0	0	1	0	0
PYGB	5834	broad.mit.edu	37	20	25259060	25259060	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr20:25259060G>T	ENST00000216962.4	+	8	1071	c.961G>T	c.(961-963)Gac>Tac	p.D321Y		NM_002862.3	NP_002853.2	P11216	PYGB_HUMAN	phosphorylase, glycogen; brain	321					glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	31					Pyridoxal Phosphate(DB00114)	CGGCTGCCGGGACCCTGTGAG	0.632000													8	51					5.68852e-11	6.3731e-11	1	1	0
AHR	196	broad.mit.edu	37	7	17375399	17375399	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr7:17375399G>C	ENST00000242057.4	+	9	1792	c.1149G>C	c.(1147-1149)caG>caC	p.Q383H	AHR_ENST00000492120.1_3'UTR	NM_001621.4	NP_001612.1	P35869	AHR_HUMAN	aryl hydrocarbon receptor	383	PAC.				apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding	p.Q383H(2)		NS(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(11)|ovary(1)|pancreas(1)|urinary_tract(3)	33	Lung NSC(10;0.0392)|all_lung(11;0.0754)					TTGTAACTCAGAGACCACTAA	0.348000													3	25					0	0	1	0	0
KIAA1033	23325	broad.mit.edu	37	12	105520099	105520099	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr12:105520099G>A	ENST00000332180.5	+	12	1084	c.997G>A	c.(997-999)Gat>Aat	p.D333N		NM_015275.1	NP_056090.1	Q2M389	WAHS7_HUMAN	KIAA1033	333					endosome transport	WASH complex				breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	41						TCGAACTATTGATAAAAAGTT	0.294000													11	52					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168830608	168830608	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:168830608C>G	ENST00000464456.1	-	8	3180	c.1980G>C	c.(1978-1980)ttG>ttC	p.L660F	MECOM_ENST00000264674.3_Missense_Mutation_p.L725F|MECOM_ENST00000433243.2_Missense_Mutation_p.L661F|MECOM_ENST00000468789.1_Missense_Mutation_p.L660F|MECOM_ENST00000460814.1_Missense_Mutation_p.L660F|MECOM_ENST00000392736.3_Missense_Mutation_p.L660F|MECOM_ENST00000472280.1_Missense_Mutation_p.L661F|MECOM_ENST00000494292.1_Missense_Mutation_p.L848F	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity	p.L660F(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						GAGAAGGCCTCAAGTATTTCT	0.363000													6	83					0	0	1	0	0
AKR1E2	83592	broad.mit.edu	37	10	4883978	4883978	+	Splice_Site	SNP	G	G	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr10:4883978G>T	ENST00000298375.7	+	7	753	c.682G>T	c.(682-684)Gag>Tag	p.E228*	AKR1E2_ENST00000345253.5_Intron|AKR1E2_ENST00000525281.1_Intron|AKR1E2_ENST00000334019.4_Intron|AKR1E2_ENST00000532248.1_Intron	NM_001040177.2	NP_001035267.1	Q96JD6	AKCL2_HUMAN	aldo-keto reductase family 1, member E2	228						cytoplasm	1,5-anhydro-D-fructose reductase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)	15						TCTCTCTAGTGAGGGGGTTGA	0.488000													5	28					0.0293803	0.0297609	1	1	0
TRIM16	10626	broad.mit.edu	37	17	15539571	15539571	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr17:15539571C>T	ENST00000455584.2	-	3	671	c.628G>A	c.(628-630)Gag>Aag	p.E210K	TRIM16_ENST00000581224.1_5'UTR|TRIM16_ENST00000579219.1_5'UTR|TRIM16_ENST00000577886.1_5'UTR|TRIM16_ENST00000336708.7_Missense_Mutation_p.E210K|TRIM16_ENST00000416464.2_Missense_Mutation_p.E80K|TRIM16_ENST00000578237.1_Missense_Mutation_p.E210K																							GCTTTGACCTCTGACACCGAC	0.522000													5	46					0	0	1	0	0
OR2J3	442186	broad.mit.edu	37	6	29080385	29080385	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr6:29080385G>T	ENST00000377169.1	+	1	718	c.718G>T	c.(718-720)Gtg>Ttg	p.V240L		NM_001005216.2	NP_001005216.2	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J, member 3	240					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(5)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	24						GCTTCAGAAAGTGTTTGGAAC	0.453000													16	51					1.15088e-07	1.24652e-07	1	1	0
UBP1	7342	broad.mit.edu	37	3	33458307	33458307	+	Silent	SNP	C	C	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:33458307C>A	ENST00000283629.3	-	3	814	c.285G>T	c.(283-285)cgG>cgT	p.R95R	UBP1_ENST00000283628.5_Silent_p.R95R|UBP1_ENST00000447368.2_Silent_p.R95R	NM_001128161.1|NM_014517.4	NP_001121633.1|NP_055332.3	Q9NZI7	UBIP1_HUMAN	upstream binding protein 1 (LBP-1a)	95					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(2)|kidney(4)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|urinary_tract(2)	23						TATCCAGCATCCGAATTTCAT	0.318000													3	43					0.115264	0.115857	1	1	0
SLC22A13	9390	broad.mit.edu	37	3	38317440	38317440	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:38317440C>G	ENST00000311856.4	+	7	1139	c.1090C>G	c.(1090-1092)Ctg>Gtg	p.L364V	SLC22A13_ENST00000450935.2_3'UTR	NM_004256.3	NP_004247.2	Q9Y226	S22AD_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 13	364						integral to plasma membrane	organic cation transmembrane transporter activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|urinary_tract(1)	20				KIRC - Kidney renal clear cell carcinoma(284;0.0533)|Kidney(284;0.067)		GGACGTCTATCTGACGCAGCT	0.567000													6	27					0	0	1	0	0
ZBTB41	360023	broad.mit.edu	37	1	197147629	197147629	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:197147629C>T	ENST00000367405.4	-	6	1758	c.1690G>A	c.(1690-1692)Gaa>Aaa	p.E564K	ZBTB41_ENST00000467322.1_5'UTR	NM_194314.2	NP_919290.2	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	564					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(11)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	40						CTCAAATGTTCTTTCAAAGTA	0.308000													10	24					0	0	1	0	0
N6AMT1	29104	broad.mit.edu	37	21	30257611	30257611	+	Silent	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr21:30257611G>A	ENST00000303775.5	-	1	82	c.57C>T	c.(55-57)ttC>ttT	p.F19F	N6AMT1_ENST00000351429.3_Silent_p.F19F	NM_013240.4	NP_037372	Q9Y5N5	HEMK2_HUMAN	N-6 adenine-specific DNA methyltransferase 1 (putative)	19					positive regulation of cell growth	protein complex	nucleic acid binding|protein binding|protein methyltransferase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)	12						ACACGTCGCTGAAGGCGCCGC	0.682000													6	57					0	0	1	0	0
VPS35	55737	broad.mit.edu	37	16	46696966	46696966	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr16:46696966G>C	ENST00000299138.7	-	14	1814	c.1756C>G	c.(1756-1758)Caa>Gaa	p.Q586E		NM_018206.4	NP_060676.2	Q96QK1	VPS35_HUMAN	vacuolar protein sorting 35 homolog (S. cerevisiae)	586					protein transport|retrograde transport, endosome to Golgi	cytosol|endosome|membrane	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|pancreas(1)|prostate(1)|urinary_tract(1)	23		all_cancers(37;7.65e-05)|all_epithelial(9;0.000154)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				AGTGCTCCTTGAAGAAAAAGT	0.418000													14	64					0	0	1	0	0
DPEP3	64180	broad.mit.edu	37	16	68011252	68011252	+	Silent	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr16:68011252C>T	ENST00000268793.4	-	7	1387	c.1014G>A	c.(1012-1014)aaG>aaA	p.K338K		NM_001129758.1|NM_022357.3	NP_001123230.1|NP_071752.3	Q9H4B8	DPEP3_HUMAN	dipeptidase 3	313					meiosis	anchored to membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			breast(4)|endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)	20		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0117)|Epithelial(162;0.0481)|all cancers(182;0.236)		TGCCACCGTTCTTCTTCTAGA	0.567000													3	20					0	0	1	0	0
ZNF135	7694	broad.mit.edu	37	19	58578485	58578485	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:58578485G>C	ENST00000506786.1	+	5	1061	c.507G>C	c.(505-507)gaG>gaC	p.E169D	ZNF135_ENST00000359978.6_Missense_Mutation_p.E223D|ZNF135_ENST00000439855.2_Missense_Mutation_p.E211D|ZNF135_ENST00000401053.4_Missense_Mutation_p.E235D|ZNF135_ENST00000511556.1_Missense_Mutation_p.E223D|ZNF135_ENST00000313434.5_Missense_Mutation_p.E211D			B4DHH9	B4DHH9_HUMAN	zinc finger protein 135	223					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(26)|ovary(1)|skin(1)|urinary_tract(1)	41		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		GTGTAAAAGAGAAACCCTACA	0.473000													9	66					0	0	1	0	0
MORC3	23515	broad.mit.edu	37	21	37721669	37721669	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr21:37721669C>T	ENST00000400485.1	+	9	1142	c.1066C>T	c.(1066-1068)Cat>Tat	p.H356Y	MORC3_ENST00000487909.1_3'UTR	NM_015358.2	NP_056173.1	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	356					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	35						TAAGCCAACTCATAATAAACA	0.328000													3	30					0	0	1	0	0
SUZ12P1	440423	broad.mit.edu	37	17	29061941	29061941	+	RNA	SNP	T	T	C	rs112064181	by1000genomes	TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr17:29061941T>C	ENST00000582557.1	+	0	861																											TAGATTTCTTTGAACTCGGAA	0.303000													4	152					0	0	1	0	0
ZNF655	79027	broad.mit.edu	37	7	99170672	99170672	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr7:99170672G>A	ENST00000424881.1	+	4	1266	c.1046G>A	c.(1045-1047)cGt>cAt	p.R349H	ZNF655_ENST00000493277.1_Missense_Mutation_p.R349H|ZNF655_ENST00000425063.1_3'UTR|ZNF655_ENST00000394163.2_Missense_Mutation_p.R314H|GS1-259H13.10_ENST00000486324.1_Intron|ZNF655_ENST00000419215.2_3'UTR|ZNF655_ENST00000252713.4_Missense_Mutation_p.R314H|GS1-259H13.10_ENST00000455905.1_Intron	NM_001083956.1|NM_001085368.1	NP_001077425.1|NP_001078837.1	Q8N720	ZN655_HUMAN	zinc finger protein 655	314					G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	16	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					GTCTTCAGTCGTAGTGTCCAC	0.403000													79	55					0	0	1	0	0
LRP6	4040	broad.mit.edu	37	12	12332875	12332875	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr12:12332875C>G	ENST00000261349.4	-	7	1490	c.1414G>C	c.(1414-1416)Gag>Cag	p.E472Q	LRP6_ENST00000543091.1_Missense_Mutation_p.E472Q	NM_002336.2	NP_002327.2	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein 6	472	Beta-propeller 2.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(28)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	85		Prostate(47;0.0865)				GCTGCTCGCTCAATTTTCGGA	0.363000													8	62					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7580810	7580810	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr6:7580810G>A	ENST00000379802.3	+	23	4728	c.4387G>A	c.(4387-4389)Gta>Ata	p.V1463I	DSP_ENST00000418664.2_Intron	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1463	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AGAGGAGAGCGTAAGATATAA	0.443000													5	55					0	0	1	0	0
CTSZ	1522	broad.mit.edu	37	20	57581417	57581417	+	Silent	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr20:57581417G>A	ENST00000217131.5	-	2	385	c.267C>T	c.(265-267)tgC>tgT	p.C89C		NM_001336.3	NP_001327.2	Q9UBR2	CATZ_HUMAN	cathepsin Z	89					proteolysis	endoplasmic reticulum|extracellular space|lysosome	cysteine-type endopeptidase activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(4)	10	all_lung(29;0.00711)		Colorectal(105;0.109)			AGCAGGAGCCGCAGTATTGGG	0.632000													4	17					0	0	1	0	0
C5orf42	65250	broad.mit.edu	37	5	37183334	37183334	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr5:37183334G>A	ENST00000274258.7	-	26	5179	c.1592C>T	c.(1591-1593)tCa>tTa	p.S531L	C5orf42_ENST00000508244.1_Missense_Mutation_p.S1650L|C5orf42_ENST00000425232.2_Missense_Mutation_p.S1650L			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	1650										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			AACCAGTACTGATGATGAAAG	0.333000													6	42					0	0	1	0	0
SLC10A3	8273	broad.mit.edu	37	X	153717065	153717065	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chrX:153717065G>C	ENST00000263512.4	-	2	713	c.215C>G	c.(214-216)tCt>tGt	p.S72C	SLC10A3_ENST00000393586.1_Missense_Mutation_p.S127C|SLC10A3_ENST00000369649.4_Missense_Mutation_p.S72C|SLC10A3_ENST00000393587.4_Missense_Mutation_p.S72C	NM_019848.3	NP_062822.1	P09131	P3_HUMAN	solute carrier family 10, member 3	72					organic anion transport	integral to membrane	bile acid:sodium symporter activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTCCATCACAGAGCCATCTCC	0.637000													12	95					0	0	1	0	0
PDE11A	50940	broad.mit.edu	37	2	178545577	178545577	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:178545577G>C	ENST00000286063.6	-	16	2717	c.2400C>G	c.(2398-2400)atC>atG	p.I800M	PDE11A_ENST00000358450.4_Missense_Mutation_p.I550M|PDE11A_ENST00000449286.2_Missense_Mutation_p.I442M|PDE11A_ENST00000389683.3_Missense_Mutation_p.I356M|PDE11A_ENST00000409504.1_Missense_Mutation_p.I442M	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A		Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			GATGGTTTTTGATGTTCCAAT	0.318000									Primary Pigmented Nodular Adrenocortical Disease, Familial				3	30					0	0	1	0	0
UMPS	7372	broad.mit.edu	37	3	124449419	124449419	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:124449419C>T	ENST00000232607.2	+	1	207	c.101C>T	c.(100-102)tCc>tTc	p.S34F	UMPS_ENST00000413078.2_5'UTR|UMPS_ENST00000538242.1_5'UTR|UMPS_ENST00000536109.1_5'UTR	NM_000373.3	NP_000364.1	P11172	UMPS_HUMAN	uridine monophosphate synthetase	34	OPRTase.				'de novo' pyrimidine base biosynthetic process|'de novo' UMP biosynthetic process|pyrimidine nucleoside biosynthetic process	cytosol|nucleus	orotate phosphoribosyltransferase activity|orotidine-5'-phosphate decarboxylase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	16				GBM - Glioblastoma multiforme(114;0.146)		GGGCTTTCCTCCCCCATCTAC	0.607000													8	56					0	0	1	0	0
SECISBP2	79048	broad.mit.edu	37	9	91972404	91972404	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr9:91972404G>A	ENST00000375807.3	+	15	2263	c.2192G>A	c.(2191-2193)cGc>cAc	p.R731H	SECISBP2_ENST00000339901.4_Missense_Mutation_p.R658H|SECISBP2_ENST00000534113.2_Missense_Mutation_p.R663H	NM_001282688.1|NM_001282690.1|NM_024077.3	NP_001269617.1|NP_001269619.1|NP_076982.3	Q96T21	SEBP2_HUMAN	SECIS binding protein 2	731					translation	nucleus	mRNA 3'-UTR binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(3)|skin(2)	32						GCTCTCAACCGCAAAGCTCTG	0.507000													30	95					0	0	1	0	0
MTHFS	10588	broad.mit.edu	37	15	80137639	80137639	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr15:80137639G>C	ENST00000258874.3	-	3	585	c.525C>G	c.(523-525)ttC>ttG	p.F175L	ST20-MTHFS_ENST00000479961.1_Missense_Mutation_p.F151L	NM_006441.3	NP_006432.1	P49914	MTHFS_HUMAN	5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)	175					folic acid-containing compound biosynthetic process|formate metabolic process|tetrahydrofolate metabolic process	cytosol|Golgi apparatus|plasma membrane	5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|folic acid binding			endometrium(3)|large_intestine(1)|liver(1)	5				all cancers(203;0.00467)		TCTGTTCTTTGAAAGCCAACG	0.488000													29	76					0	0	1	0	0
SNCB	6620	broad.mit.edu	37	5	176053481	176053481	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr5:176053481C>T	ENST00000310112.3	-	5	450	c.200G>A	c.(199-201)gGa>gAa	p.G67E	SNCB_ENST00000393693.2_Missense_Mutation_p.G67E|SNCB_ENST00000506696.1_Missense_Mutation_p.G67E|SNCB_ENST00000510387.1_Missense_Mutation_p.G67E	NM_001001502.1	NP_001001502.1	Q16143	SYUB_HUMAN	synuclein, beta	67	4 X 11 AA tandem repeats of [EGS]-K-T-K- [EQ]-[GQ]-V-X(4).						calcium ion binding|phospholipase inhibitor activity			breast(1)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	10	all_cancers(89;0.00222)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CACAGCTCCTCCCAGATGTGA	0.577000													4	31					0	0	1	0	0
LRRN3	54674	broad.mit.edu	37	7	110764585	110764585	+	Nonsense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr7:110764585C>G	ENST00000451085.1	+	4	2803	c.1757C>G	c.(1756-1758)tCa>tGa	p.S586*	LRRN3_ENST00000308478.5_Nonsense_Mutation_p.S586*|LRRN3_ENST00000422987.3_Nonsense_Mutation_p.S586*|IMMP2L_ENST00000331762.3_Intron|IMMP2L_ENST00000405709.2_Intron|IMMP2L_ENST00000450877.1_Intron|IMMP2L_ENST00000452895.1_Intron|IMMP2L_ENST00000447215.1_Intron|IMMP2L_ENST00000437687.1_Intron|IMMP2L_ENST00000415362.1_Intron|IMMP2L_ENST00000489381.1_Intron	NM_001099660.1	NP_001093130.1	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3	586	Fibronectin type-III.					integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(15)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		CTGAATCCATCAACTGAGTAT	0.358000													5	39					0	0	1	0	0
CREG2	200407	broad.mit.edu	37	2	101971819	101971819	+	Silent	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:101971819G>A	ENST00000324768.5	-	3	758	c.621C>T	c.(619-621)atC>atT	p.I207I		NM_153836.3	NP_722578.1	Q8IUH2	CREG2_HUMAN	cellular repressor of E1A-stimulated genes 2							extracellular region	FMN binding	p.I207I(1)		endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|skin(1)	10						CCGGATCAACGATGTTTTTTC	0.393000													4	21					0	0	1	0	0
RIF1	55183	broad.mit.edu	37	2	152276738	152276738	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:152276738G>C	ENST00000243326.5	+	6	1021	c.538G>C	c.(538-540)Gag>Cag	p.E180Q	RIF1_ENST00000430328.2_Missense_Mutation_p.E180Q|RIF1_ENST00000428287.2_Missense_Mutation_p.E180Q|RIF1_ENST00000444746.2_Missense_Mutation_p.E180Q|RIF1_ENST00000433166.2_Missense_Mutation_p.E180Q|RIF1_ENST00000453091.2_Missense_Mutation_p.E180Q			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)						cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		AATGGGAGAAGAGGCAGTGAG	0.413000													4	34					0	0	1	0	0
FXYD4	53828	broad.mit.edu	37	10	43871490	43871490	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr10:43871490G>C	ENST00000476166.1	+	8	557	c.223G>C	c.(223-225)Gag>Cag	p.E75Q	FXYD4_ENST00000480834.1_3'UTR	NM_173160.2	NP_775183.1	P59646	FXYD4_HUMAN	FXYD domain containing ion transport regulator 4	75						integral to membrane				NS(1)|large_intestine(1)|lung(3)	5						TCCTGTACCTGAGAAGGCCAT	0.582000													8	53					0	0	1	0	0
LANCL2	55915	broad.mit.edu	37	7	55459488	55459488	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr7:55459488C>G	ENST00000254770.2	+	2	785	c.207C>G	c.(205-207)atC>atG	p.I69M		NM_018697.3	NP_061167.1	Q9NS86	LANC2_HUMAN	LanC lantibiotic synthetase component C-like 2 (bacterial)	69					negative regulation of transcription, DNA-dependent|positive regulation of abscisic acid mediated signaling pathway	cortical actin cytoskeleton|cytosol|nucleus|plasma membrane	ATP binding|catalytic activity|GTP binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	25	Breast(14;0.0379)		Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00128)|Epithelial(13;0.0706)			GATCTCAGATCATTCATAATT	0.368000													6	35					0	0	1	0	0
DHX35	60625	broad.mit.edu	37	20	37623488	37623488	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr20:37623488C>G	ENST00000252011.3	+	8	640	c.607C>G	c.(607-609)Cga>Gga	p.R203G	DHX35_ENST00000373325.2_Missense_Mutation_p.R203G|DHX35_ENST00000373323.4_Missense_Mutation_p.R172G	NM_021931.3	NP_068750.2	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	203	Helicase ATP-binding.					catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|urinary_tract(2)	40		Myeloproliferative disorder(115;0.00878)				AGGGGATCTTCGATTGATTGT	0.398000													15	142					0	0	1	0	0
ZNF197	10168	broad.mit.edu	37	3	44684377	44684377	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:44684377G>C	ENST00000396058.1	+	5	1922	c.1755G>C	c.(1753-1755)caG>caC	p.Q585H	RP11-944L7.4_ENST00000457331.1_RNA|ZNF197_ENST00000383745.2_Intron|ZNF197_ENST00000344387.4_Missense_Mutation_p.Q585H|ZNF197_ENST00000383744.4_Intron			O14709	ZN197_HUMAN	zinc finger protein 197	585					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(1)	25				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		TCTTACATCAGAGAGTCCACA	0.403000													8	87					0	0	1	0	0
C5orf42	65250	broad.mit.edu	37	5	37183433	37183433	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr5:37183433G>C	ENST00000274258.7	-	26	5080	c.1493C>G	c.(1492-1494)tCt>tGt	p.S498C	C5orf42_ENST00000508244.1_Missense_Mutation_p.S1617C|C5orf42_ENST00000425232.2_Missense_Mutation_p.S1617C			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	1617										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			AACAAAGCAAGAACCAGCTCT	0.333000													3	41					0	0	1	0	0
SLC24A2	25769	broad.mit.edu	37	9	19576938	19576938	+	Silent	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr9:19576938C>T	ENST00000341998.2	-	5	1273	c.1212G>A	c.(1210-1212)ggG>ggA	p.G404G	SLC24A2_ENST00000286344.3_Silent_p.G387G	NM_001193288.2|NM_020344.3	NP_001180217.1|NP_065077.1	Q9UI40	NCKX2_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2	404					visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		GGTTGGCAGCCCCATTCTGCC	0.542000													4	41					0	0	1	0	0
HR	55806	broad.mit.edu	37	8	21978696	21978696	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr8:21978696C>T	ENST00000381418.4	-	10	3729	c.2249G>A	c.(2248-2250)cGa>cAa	p.R750Q	HR_ENST00000312841.8_Missense_Mutation_p.R750Q	NM_005144.4	NP_005135.2	O43593	HAIR_HUMAN	hair growth associated	750							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	27		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		CAGGGGCCCTCGGCCAGCACG	0.637000													6	94					0	0	1	0	0
CECR2	27443	broad.mit.edu	37	22	18028504	18028504	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr22:18028504A>G	ENST00000400573.5	+	17	3468	c.3461A>G	c.(3460-3462)tAt>tGt	p.Y1154C	CECR2_ENST00000262608.8_Missense_Mutation_p.Y1155C|CECR2_ENST00000400585.2_Missense_Mutation_p.Y1012C			Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2						chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		TTTCCCCGGTATCGCCCCCCA	0.572000													4	21					0	0	1	0	0
RNF133	168433	broad.mit.edu	37	7	122338241	122338241	+	Silent	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr7:122338241C>T	ENST00000340112.2	-	1	969	c.732G>A	c.(730-732)gaG>gaA	p.E244E	CADPS2_ENST00000412584.2_Intron|CADPS2_ENST00000313070.7_Intron|CADPS2_ENST00000334010.7_Intron|CADPS2_ENST00000449022.2_Intron	NM_139175.1	NP_631914.1	Q8WVZ7	RN133_HUMAN	ring finger protein 133	244						endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	21						CTTCATCCCCCTCTTTTACTA	0.383000													4	132					0	0	1	0	0
GNAT3	346562	broad.mit.edu	37	7	80108170	80108170	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr7:80108170C>T	ENST00000398291.3	-	4	541	c.448G>A	c.(448-450)Gac>Aac	p.D150N	CD36_ENST00000435819.1_Intron	NM_001102386.1	NP_001095856.1	A8MTJ3	GNAT3_HUMAN	guanine nucleotide binding protein, alpha transducing 3	150					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction|sensory perception of sweet taste|sensory perception of umami taste	cytoplasm|heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			endometrium(1)|large_intestine(2)|lung(5)|ovary(1)	9						GCTGCTGAGTCATTGAGCTGA	0.388000													8	51					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102124637	102124637	+	Silent	SNP	C	C	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr6:102124637C>A	ENST00000369138.1	+	4	1171	c.681C>A	c.(679-681)atC>atA	p.I227I	GRIK2_ENST00000369137.3_Silent_p.I227I|GRIK2_ENST00000358361.3_Silent_p.I227I|GRIK2_ENST00000421544.1_Silent_p.I227I|GRIK2_ENST00000318991.6_Silent_p.I227I|GRIK2_ENST00000413795.1_Silent_p.I227I|GRIK2_ENST00000369134.4_Silent_p.I178I	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	227					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	TTCATGTAATCTTTGATTGTA	0.338000													7	29					0.0293803	0.0297609	1	1	0
GPR161	23432	broad.mit.edu	37	1	168066295	168066295	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:168066295G>A	ENST00000367838.1	-	5	863	c.550C>T	c.(550-552)Cgg>Tgg	p.R184W	GPR161_ENST00000367835.1_Missense_Mutation_p.R184W|GPR161_ENST00000537209.1_Missense_Mutation_p.R204W|GPR161_ENST00000361697.2_Missense_Mutation_p.R184W|GPR161_ENST00000539777.1_Missense_Mutation_p.R106W|GPR161_ENST00000271357.5_Missense_Mutation_p.R184W|GPR161_ENST00000367836.1_Missense_Mutation_p.R52W|GPR161_ENST00000546300.1_Missense_Mutation_p.R70W	NM_001267611.1|NM_153832.2	NP_001254540.1|NP_722561.1	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161	184					multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|skin(1)	26	all_hematologic(923;0.215)					CCAGGCTCCCGGTGCCAAGCA	0.587000													34	19					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153054128	153054128	+	Silent	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr5:153054128G>A	ENST00000285900.5	+	6	1111	c.768G>A	c.(766-768)gtG>gtA	p.V256V	GRIA1_ENST00000518142.1_Silent_p.V176V|GRIA1_ENST00000518783.1_Silent_p.V266V|GRIA1_ENST00000448073.4_Silent_p.V266V|GRIA1_ENST00000521843.2_Silent_p.V187V|GRIA1_ENST00000340592.5_Silent_p.V256V	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	256					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TCCAGCTGGTGAACTACACAG	0.512000													10	166					0	0	1	0	0
SMOX	54498	broad.mit.edu	37	20	4168019	4168019	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr20:4168019G>A	ENST00000305958.4	+	7	1858	c.1633G>A	c.(1633-1635)Gag>Aag	p.E545K	SMOX_ENST00000346595.2_Missense_Mutation_p.E180K|SMOX_ENST00000339123.6_Missense_Mutation_p.E492K|SMOX_ENST00000379460.2_Missense_Mutation_p.E545K|SMOX_ENST00000278795.3_Missense_Mutation_p.E522K	NM_175839.2	NP_787033.1	Q9NWM0	SMOX_HUMAN	spermine oxidase	545					polyamine biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	polyamine oxidase activity			breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(7)|lung(5)|skin(2)|urinary_tract(1)	26					Spermine(DB00127)	CCGCCTCATTGAGATGTACCG	0.627000													5	32					0	0	1	0	0
ZNF808	388558	broad.mit.edu	37	19	53057298	53057298	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:53057298G>A	ENST00000359798.4	+	5	1309	c.1129G>A	c.(1129-1131)Gag>Aag	p.E377K		NM_001039886.3	NP_001034975.2	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	377					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(8)|kidney(3)|lung(12)|urinary_tract(1)	24				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		TAAGATTTGTGAGAAGGCTTT	0.378000													12	121					0	0	1	0	0
COPS3	8533	broad.mit.edu	37	17	17171213	17171213	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr17:17171213C>T	ENST00000539941.2	-	5	575	c.367G>A	c.(367-369)Gct>Act	p.A123T	COPS3_ENST00000268717.5_Missense_Mutation_p.A143T|COPS3_ENST00000439936.2_Missense_Mutation_p.A123T	NM_001199125.1	NP_001186054.1	Q9UNS2	CSN3_HUMAN	COP9 signalosome subunit 3	143					cullin deneddylation|response to light stimulus|signal transduction	cytoplasm|signalosome	protein binding			NS(1)|large_intestine(3)|lung(6)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	13						CAGAGATCAGCATGTATTGAG	0.448000													12	49					0	0	1	0	0
WAPAL	23063	broad.mit.edu	37	10	88259540	88259540	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr10:88259540G>C	ENST00000298767.5	-	3	1932	c.1460C>G	c.(1459-1461)tCc>tGc	p.S487C		NM_015045.2	NP_055860.1	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog (Drosophila)	487	Mediates interaction with the cohesin complex.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(6)|lung(13)|ovary(2)|stomach(1)	31						AGGCTGCAAGGAGGGTGATGG	0.383000													13	57					0	0	1	0	0
N4BP2L2	10443	broad.mit.edu	37	13	33110366	33110366	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr13:33110366C>G	ENST00000267068.3	-	2	963	c.799G>C	c.(799-801)Gaa>Caa	p.E267Q	N4BP2L2_ENST00000446957.2_Missense_Mutation_p.E267Q|N4BP2L2_ENST00000504114.1_Intron|N4BP2L2_ENST00000357505.6_Intron|N4BP2L2_ENST00000399396.3_Intron	NM_014887.2	NP_055702.1	Q92802	N42L2_HUMAN	NEDD4 binding protein 2-like 2	267										kidney(4)|large_intestine(3)|liver(1)|lung(6)|skin(1)|urinary_tract(1)	16		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		GACTGCCATTCAGGCCTGAAA	0.408000													11	45					0	0	1	0	0
RUFY4	285180	broad.mit.edu	37	2	218947875	218947875	+	Silent	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:218947875G>A	ENST00000374155.3	+	10	1868	c.1458G>A	c.(1456-1458)caG>caA	p.Q486Q	RUFY4_ENST00000441828.2_3'UTR|RUFY4_ENST00000344321.7_Silent_p.Q466Q			Q6ZNE9	RUFY4_HUMAN	RUN and FYVE domain containing 4	466							metal ion binding			endometrium(2)|kidney(2)|large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(1)	10		Renal(207;0.0915)		Epithelial(149;4.11e-06)|all cancers(144;0.000519)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		AGCTGGAGCAGAAGCAACAGG	0.592000													3	23					0	0	1	0	0
OR6F1	343169	broad.mit.edu	37	1	247875356	247875356	+	Silent	SNP	C	C	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:247875356C>A	ENST00000302084.2	-	1	749	c.702G>T	c.(700-702)cgG>cgT	p.R234R	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005286.1	NP_001005286.1	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F, member 1	234					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(5)|lung(34)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)	47	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			AGGCTTTGCTCCGGCCACTGG	0.522000													12	77					1.41608e-15	1.59564e-15	1	1	0
GTPBP4	23560	broad.mit.edu	37	10	1060190	1060190	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr10:1060190C>T	ENST00000360803.4	+	15	1628	c.1546C>T	c.(1546-1548)Cag>Tag	p.Q516*	GTPBP4_ENST00000545048.1_Nonsense_Mutation_p.Q469*|GTPBP4_ENST00000538293.1_Nonsense_Mutation_p.Q400*	NM_012341.2	NP_036473.2	Q9BZE4	NOG1_HUMAN	GTP binding protein 4	516					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(1)	21		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		TTCTCAGGTTCAGAGGACAGT	0.368000													6	53					0	0	1	0	0
ZSWIM1	90204	broad.mit.edu	37	20	44512069	44512069	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr20:44512069G>T	ENST00000372523.1	+	2	933	c.838G>T	c.(838-840)Gct>Tct	p.A280S	ZSWIM1_ENST00000372520.1_Missense_Mutation_p.A280S	NM_080603.4	NP_542170.3	Q9BR11	ZSWM1_HUMAN	zinc finger, SWIM-type containing 1	280							zinc ion binding			breast(1)|endometrium(3)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	13		Myeloproliferative disorder(115;0.028)				ACAAGGTATGGCTTCTCTGTT	0.542000													9	95					1.58986e-06	1.69846e-06	1	1	0
SPAG1	6674	broad.mit.edu	37	8	101253121	101253121	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr8:101253121G>C	ENST00000388798.2	+	19	2843	c.2652G>C	c.(2650-2652)atG>atC	p.M884I	SPAG1_ENST00000251809.3_Missense_Mutation_p.M884I	NM_003114.4	NP_003105.2	Q07617	SPAG1_HUMAN	sperm associated antigen 1	884					single fertilization	cytoplasm	GTP binding|hydrolase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	30	all_cancers(14;2.35e-05)|all_epithelial(15;5.2e-08)|Lung NSC(17;0.000283)|all_lung(17;0.000823)	Breast(495;0.195)	Epithelial(11;1.12e-09)|all cancers(13;1.26e-07)|OV - Ovarian serous cystadenocarcinoma(57;4.37e-05)|STAD - Stomach adenocarcinoma(118;0.0525)	KIRC - Kidney renal clear cell carcinoma(542;0.00178)|READ - Rectum adenocarcinoma(644;0.236)		TCTTTTAGATGATGTTGACAC	0.313000													7	345					0	0	1	0	0
RANBP17	64901	broad.mit.edu	37	5	170692835	170692835	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr5:170692835C>T	ENST00000523189.1	+	25	3091	c.2927C>T	c.(2926-2928)cCa>cTa	p.P976L	RANBP17_ENST00000521759.1_3'UTR	NM_022897.3	NP_075048.1	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	976					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	50	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CAGCAAAACCCAGATGTCCTG	0.488000			T	TRD@	ALL								6	61					0	0	1	0	0
SLC16A7	9194	broad.mit.edu	37	12	60168919	60168919	+	Silent	SNP	G	G	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr12:60168919G>T	ENST00000261187.4	+	4	1007	c.843G>T	c.(841-843)tcG>tcT	p.S281S	SLC16A7_ENST00000543448.1_Silent_p.S182S|SLC16A7_ENST00000552024.1_Silent_p.S281S|SLC16A7_ENST00000547379.1_Silent_p.S281S|SLC16A7_ENST00000552432.1_Silent_p.S281S	NM_004731.4	NP_004722.2	O60669	MOT2_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 7	281						integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			endometrium(1)|large_intestine(14)|liver(2)|lung(11)|ovary(1)|skin(1)	30				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	ATGAGTACTCGGCAGCTTTTC	0.383000													10	134					1.76689e-08	1.93517e-08	1	1	0
LCN12	286256	broad.mit.edu	37	9	139847415	139847415	+	Silent	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr9:139847415C>T	ENST00000371633.3	+	2	186	c.186C>T	c.(184-186)aaC>aaT	p.N62N		NM_178536.3	NP_848631.2	Q6JVE5	LCN12_HUMAN	lipocalin 12	62					lipid metabolic process	extracellular region	binding|transporter activity			endometrium(1)|kidney(1)|lung(1)|prostate(2)	5	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.19)	OV - Ovarian serous cystadenocarcinoma(145;7.8e-06)|Epithelial(140;0.000106)		CGCTGCTGAACGCTTTCACCG	0.627000													19	85					0	0	1	0	0
LILRA3	11026	broad.mit.edu	37	19	54803223	54803223	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:54803223C>T	ENST00000391745.1	-	8	821	c.505G>A	c.(505-507)Gat>Aat	p.D169N	LILRA3_ENST00000251390.3_Missense_Mutation_p.D152N|LILRA3_ENST00000391744.3_Missense_Mutation_p.D152N					leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3											NS(3)|breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ATGAAGCCATCAAATGCCACC	0.567000													11	59					0	0	1	0	0
CHIA	27159	broad.mit.edu	37	1	111857942	111857942	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:111857942C>T	ENST00000369740.1	+	6	468	c.365C>T	c.(364-366)tCa>tTa	p.S122L	CHIA_ENST00000430615.1_Missense_Mutation_p.S14L|CHIA_ENST00000483391.1_Intron|CHIA_ENST00000451398.2_5'UTR|CHIA_ENST00000353665.6_Intron|CHIA_ENST00000343320.6_Missense_Mutation_p.S122L	NM_001258001.1|NM_201653.3	NP_001244930.1|NP_970615.2	Q9BZP6	CHIA_HUMAN	chitinase, acidic	122					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	23		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		TTCATCACCTCAGTCATCAAA	0.547000													17	84					0	0	1	0	0
IL27RA	9466	broad.mit.edu	37	19	14150583	14150583	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:14150583G>A	ENST00000263379.2	+	4	520	c.395G>A	c.(394-396)cGg>cAg	p.R132Q		NM_004843.3	NP_004834.1	Q6UWB1	I27RA_HUMAN	interleukin 27 receptor, alpha	132					cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	26						AACGCCCCCCGGCTGGGCCCT	0.627000													10	56					0	0	1	0	0
OR9Q2	219957	broad.mit.edu	37	11	57958200	57958200	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr11:57958200C>G	ENST00000311591.3	+	1	295	c.238C>G	c.(238-240)Cag>Gag	p.Q80E		NM_001005283.2	NP_001005283.1	Q8NGE9	OR9Q2_HUMAN	olfactory receptor, family 9, subfamily Q, member 2	80					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|large_intestine(3)|lung(24)|ovary(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	41		Breast(21;0.0589)				CATCATCCCTCAGATGCTGGC	0.582000													5	47					0	0	1	0	0
CXorf36	79742	broad.mit.edu	37	X	45051120	45051120	+	Nonsense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chrX:45051120G>C	ENST00000398000.2	-	2	448	c.374C>G	c.(373-375)tCa>tGa	p.S125*	CXorf36_ENST00000377934.4_Nonsense_Mutation_p.S125*|RP11-342D14.1_ENST00000438181.1_RNA|CXorf36_ENST00000477281.1_5'UTR|RP11-342D14.1_ENST00000450527.1_RNA	NM_176819.3	NP_789789.2	Q9H7Y0	CX036_HUMAN	chromosome X open reading frame 36	125						extracellular region				endometrium(1)|large_intestine(2)|lung(4)	7						TCTCCTGTCTGAGATCTCGTT	0.483000													11	70					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	70070975	70070975	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr6:70070975G>C	ENST00000370598.1	+	29	4631	c.3810G>C	c.(3808-3810)ttG>ttC	p.L1270F	BAI3_ENST00000546190.1_Missense_Mutation_p.L234F|BAI3_ENST00000238918.8_Missense_Mutation_p.L476F	NM_001704.2	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1270					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				ATCCATGTTTGAAAAAAGAAA	0.403000													5	46					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11397296	11397296	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr5:11397296C>G	ENST00000304623.8	-	6	648	c.459G>C	c.(457-459)caG>caC	p.Q153H	CTNND2_ENST00000511377.1_Missense_Mutation_p.Q62H|CTNND2_ENST00000503622.1_Intron|CTNND2_ENST00000359640.2_Missense_Mutation_p.Q153H|CTNND2_ENST00000458100.2_5'UTR	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	153					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						GAAGTGCACTCTGGGAGAGCA	0.507000													3	24					0	0	1	0	0
DHX38	9785	broad.mit.edu	37	16	72130728	72130728	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr16:72130728C>T	ENST00000268482.3	+	3	840	c.331C>T	c.(331-333)Cgg>Tgg	p.R111W	DHX38_ENST00000536867.1_Intron	NM_014003.3	NP_054722.2	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	111					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(5)|kidney(1)|large_intestine(16)|lung(15)|pancreas(1)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	48		Ovarian(137;0.125)				CAGACATTATCGGTCTGCTCG	0.537000													14	222					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12666697	12666697	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr17:12666697C>G	ENST00000425538.1	+	14	2897	c.2697C>G	c.(2695-2697)ttC>ttG	p.F899L	RP11-1090M7.1_ENST00000584772.1_RNA|MYOCD_ENST00000343344.4_Missense_Mutation_p.F851L	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	851					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		AAGACCTCTTCAATGCACATG	0.483000													4	34					0	0	1	0	0
FBLIM1	54751	broad.mit.edu	37	1	16101286	16101286	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:16101286C>G	ENST00000375766.3	+	7	1525	c.885C>G	c.(883-885)ttC>ttG	p.F295L	FBLIM1_ENST00000375771.1_Missense_Mutation_p.F295L|FBLIM1_ENST00000441801.2_Missense_Mutation_p.F295L|FBLIM1_ENST00000400773.1_Missense_Mutation_p.F198L|FBLIM1_ENST00000332305.5_Missense_Mutation_p.F198L	NM_017556.2	NP_060026.2	Q8WUP2	FBLI1_HUMAN	filamin binding LIM protein 1	295	LIM zinc-binding 2.|PLEKHC1-binding.				cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytoskeleton|cytosol|focal adhesion|intracellular membrane-bounded organelle	zinc ion binding			large_intestine(2)|lung(4)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	16		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|READ - Rectum adenocarcinoma(331;0.0649)|STAD - Stomach adenocarcinoma(313;0.138)		TGGACGACTTCTACAGGTACG	0.622000													5	64					0	0	1	0	0
EMC4	51234	broad.mit.edu	37	15	34520658	34520658	+	Silent	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr15:34520658G>A	ENST00000267750.4	+	4	500	c.384G>A	c.(382-384)caG>caA	p.Q128Q	EMC4_ENST00000559421.1_Intron|EMC4_ENST00000559078.1_Intron|EMC4_ENST00000249209.4_Intron|EMC4_ENST00000557879.1_3'UTR	NM_016454.2	NP_057538.1			ER membrane protein complex subunit 4																		GTTCAAGCCAGAAGTTTCTTC	0.428000													32	89					0	0	1	0	0
ZNF362	149076	broad.mit.edu	37	1	33764563	33764563	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:33764563C>G	ENST00000539719.1	+	9	1349	c.1179C>G	c.(1177-1179)caC>caG	p.H393Q	ZNF362_ENST00000373428.5_Missense_Mutation_p.H393Q	NM_152493.2	NP_689706.2	Q5T0B9	ZN362_HUMAN	zinc finger protein 362	393					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(4)|lung(2)	10		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				TGTCCAAACACACGGTGGTGG	0.612000											OREG0013343	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	56					0	0	1	0	0
SLC23A2	9962	broad.mit.edu	37	20	4837816	4837816	+	Silent	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr20:4837816C>T	ENST00000379333.1	-	17	2147	c.1755G>A	c.(1753-1755)aaG>aaA	p.K585K	SLC23A2_ENST00000338244.1_Silent_p.K585K|SLC23A2_ENST00000424750.2_Silent_p.K471K	NM_203327.1	NP_976072.1	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (ascorbic acid transporter), member 2	585					L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			endometrium(1)|kidney(3)|large_intestine(9)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						CCACACCCTTCTTCCATTTCC	0.433000													5	88					0	0	1	0	0
ZNF484	83744	broad.mit.edu	37	9	95609457	95609457	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr9:95609457G>A	ENST00000395505.2	-	3	1596	c.1504C>T	c.(1504-1506)Cgg>Tgg	p.R502W	ZNF484_ENST00000375495.3_Missense_Mutation_p.R538W|ZNF484_ENST00000332591.6_Missense_Mutation_p.R502W|ANKRD19P_ENST00000473204.1_RNA|ZNF484_ENST00000395506.3_Missense_Mutation_p.R540W	NM_001261459.1|NM_001261460.1	NP_001248388.1|NP_001248389.1	Q5JVG2	ZN484_HUMAN	zinc finger protein 484	538			G -> D (in dbSNP:rs3739602).		regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|kidney(8)|large_intestine(10)|lung(10)|prostate(2)	33						ATCCTGAGCCGAGACTTCCAG	0.398000													32	102					0	0	1	0	0
TRIM10	10107	broad.mit.edu	37	6	30121796	30121796	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr6:30121796G>T	ENST00000449742.2	-	7	1471	c.1396C>A	c.(1396-1398)Ccc>Acc	p.P466T	TRIM10_ENST00000376704.3_Intron	NM_006778.3	NP_006769.2	Q9UDY6	TRI10_HUMAN	tripartite motif containing 10	466	B30.2/SPRY.					cytoplasm	zinc ion binding			ovary(1)	1						CCAAAGAAGGGAATGACCTTC	0.547000													10	37					1.58986e-06	1.69846e-06	1	1	0
CYP2C18	1562	broad.mit.edu	37	10	96454792	96454792	+	Missense_Mutation	SNP	A	A	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr10:96454792A>T	ENST00000285979.6	+	4	799	c.600A>T	c.(598-600)aaA>aaT	p.K200N	CYP2C18_ENST00000339022.5_Missense_Mutation_p.K200N|CYP2C19_ENST00000464755.1_3'UTR	NM_000772.2	NP_000763.1			cytochrome P450, family 2, subfamily C, polypeptide 18											NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	26		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		TGATGGAAAAATTCAATGAAA	0.388000													24	61					0	0	1	0	0
PABPC1	26986	broad.mit.edu	37	8	101717181	101717181	+	Silent	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr8:101717181G>A	ENST00000318607.5	-	13	2919	c.1791C>T	c.(1789-1791)ctC>ctT	p.L597L	PABPC1_ENST00000519004.1_Silent_p.L552L|PABPC1_ENST00000522387.1_Silent_p.L565L	NM_002568.3	NP_002559.2	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	597	PABC.				mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity			breast(2)|endometrium(4)|kidney(15)|large_intestine(4)|lung(13)|prostate(1)|skin(1)	40	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			CTGGAGACTCGAGCATATGAA	0.398000													9	386					0	0	1	0	0
PPP1R13B	23368	broad.mit.edu	37	14	104209113	104209113	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr14:104209113C>A	ENST00000202556.9	-	10	1480	c.1198G>T	c.(1198-1200)Gtg>Ttg	p.V400L	PPP1R13B_ENST00000555391.1_5'UTR|PPP1R13B_ENST00000423488.2_5'UTR	NM_015316.2	NP_056131.2	Q96KQ4	ASPP1_HUMAN	protein phosphatase 1, regulatory subunit 13B	400					apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			endometrium(6)|kidney(2)|large_intestine(7)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				ACTGGTTTCACGGAAGAGCTA	0.493000													10	91					6.40141e-05	6.8015e-05	1	1	0
TRAV26-1	28657	broad.mit.edu	37	14	22592096	22592096	+	RNA	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr14:22592096C>T	ENST00000390455.3	+	0	390																											CTCCCAGGGGCCACAGTATAT	0.453000													4	45					0	0	1	0	0
KIAA0513	9764	broad.mit.edu	37	16	85112027	85112027	+	Silent	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr16:85112027C>T	ENST00000566428.1	+	7	1420	c.789C>T	c.(787-789)gaC>gaT	p.D263D	KIAA0513_ENST00000538274.1_Silent_p.D263D|KIAA0513_ENST00000567328.1_Silent_p.D263D|KIAA0513_ENST00000258180.3_Silent_p.D263D			O60268	K0513_HUMAN	KIAA0513	263						cytoplasm				breast(2)|endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(9)|pancreas(1)	18				BRCA - Breast invasive adenocarcinoma(80;0.234)		TCAGGGAAGACGAGAACAAAC	0.592000													4	12					0	0	1	0	0
TEX2	55852	broad.mit.edu	37	17	62290563	62290563	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr17:62290563C>A	ENST00000258991.3	-	2	1099	c.1015G>T	c.(1015-1017)Gaa>Taa	p.E339*	TEX2_ENST00000584379.1_Nonsense_Mutation_p.E339*|TEX2_ENST00000583097.1_Nonsense_Mutation_p.E339*			Q8IWB9	TEX2_HUMAN	testis expressed 2	339					signal transduction|sphingolipid metabolic process	integral to membrane				breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		TTATTGCTTTCCAAGTGCCCA	0.473000													5	72					0.000602214	0.000627909	1	1	0
SRSF6	6431	broad.mit.edu	37	20	42088732	42088732	+	Silent	SNP	T	T	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr20:42088732T>C	ENST00000244020.3	+	4	547	c.441T>C	c.(439-441)aaT>aaC	p.N147N		NM_006275.5	NP_006266.2	Q13247	SRSF6_HUMAN	serine/arginine-rich splicing factor 6	147	RRM 2.				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|upper_aerodigestive_tract(2)	5						AACGAACAAATGAGGGTGTAA	0.418000													3	58					0	0	1	0	0
OFD1	8481	broad.mit.edu	37	X	13753386	13753386	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chrX:13753386C>T	ENST00000340096.6	+	2	359	c.32C>T	c.(31-33)gCt>gTt	p.A11V	OFD1_ENST00000380567.1_5'UTR|OFD1_ENST00000380550.3_Missense_Mutation_p.A11V|OFD1_ENST00000398395.3_Missense_Mutation_p.A11V|OFD1_ENST00000490265.1_3'UTR	NM_003611.2	NP_003602.1	O75665	OFD1_HUMAN	oral-facial-digital syndrome 1	11					cilium movement involved in determination of left/right asymmetry|G2/M transition of mitotic cell cycle	centriole|cilium|cytosol|microtubule basal body|nuclear membrane	alpha-tubulin binding|gamma-tubulin binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	25						TTTACCGTGGCTGATGTGTTG	0.473000													11	64					0	0	1	0	0
MED12	9968	broad.mit.edu	37	X	70338695	70338695	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chrX:70338695C>G	ENST00000333646.6	+	1	290	c.91C>G	c.(91-93)Cag>Gag	p.Q31E	MED12_ENST00000374080.3_Missense_Mutation_p.Q31E|MED12_ENST00000374102.1_Missense_Mutation_p.Q31E	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	31					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					GGACCCCAAACAGAAGGAGGT	0.682000			"""M, S"""		uterine leiomyoma		Opitz-Kaveggia Syndrome						3	18					0	0	1	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58563938	58563938	+	Silent	SNP	C	C	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:58563938C>A	ENST00000282326.1	+	5	793	c.546C>A	c.(544-546)ctC>ctA	p.L182L		NM_182572.3	NP_872378.3	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	182					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CTACCCAGCTCCAGCAGAGTC	0.617000													9	39					3.09899e-07	3.34725e-07	1	1	0
RGS22	26166	broad.mit.edu	37	8	101014456	101014456	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr8:101014456G>C	ENST00000360863.6	-	18	2958	c.2764C>G	c.(2764-2766)Cca>Gca	p.P922A	RGS22_ENST00000523437.1_Missense_Mutation_p.P910A|RGS22_ENST00000523287.1_Missense_Mutation_p.P741A	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	922	RGS 1.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			AGAGAAGCTGGACTGTTGGGT	0.323000													10	567					0	0	1	0	0
CLIC5	53405	broad.mit.edu	37	6	45870848	45870848	+	Missense_Mutation	SNP	C	C	T	rs147645217		TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr6:45870848C>T	ENST00000185206.6	-	6	1362	c.1210G>A	c.(1210-1212)Gcc>Acc	p.A404T	CLIC5_ENST00000339561.6_Missense_Mutation_p.A245T	NM_001114086.1	NP_001107558.1	Q9NZA1	CLIC5_HUMAN	chloride intracellular channel 5	404					female pregnancy	actin cytoskeleton|cell cortex|chloride channel complex|Golgi apparatus|insoluble fraction|microtubule organizing center	protein binding|voltage-gated chloride channel activity			endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	13						AGGCGTTTGGCGACATCAGCG	0.572000													3	26					0	0	1	0	0
UBL4A	8266	broad.mit.edu	37	X	153714142	153714142	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chrX:153714142C>A	ENST00000369660.4	-	3	416	c.331G>T	c.(331-333)Gat>Tat	p.D111Y	UBL4A_ENST00000369653.4_Missense_Mutation_p.D111Y|UBL4A_ENST00000477777.1_5'UTR	NM_014235.3	NP_055050.1	P11441	UBL4A_HUMAN	ubiquitin-like 4A	111					protein modification process|tail-anchored membrane protein insertion into ER membrane|transport	BAT3 complex	small conjugating protein ligase activity			endometrium(5)|lung(1)|urinary_tract(1)	7	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTGCTGGCATCTGCCGCACTG	0.627000													26	89					5.77227e-19	6.54191e-19	1	1	0
PCDHA13	56136	broad.mit.edu	37	5	140263026	140263026	+	Silent	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr5:140263026G>A	ENST00000289272.2	+	1	1173	c.1173G>A	c.(1171-1173)ccG>ccA	p.P391P	PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA13_ENST00000409494.1_Silent_p.P391P|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1												p.P391P(4)		NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTTGACGCCGCATGTCCCCT	0.547000													4	139					0	0	1	0	0
SH2D1B	117157	broad.mit.edu	37	1	162368817	162368817	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:162368817C>G	ENST00000367929.2	-	3	368	c.259G>C	c.(259-261)Gaa>Caa	p.E87Q	SH2D1B_ENST00000359567.3_Intron	NM_053282.4	NP_444512.2	O14796	SH21B_HUMAN	SH2 domain containing 1B	87	SH2.									kidney(1)|large_intestine(1)|lung(4)|pancreas(1)	7	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			TTTGGTTTTTCAAATTTGGAG	0.398000													13	174					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105412943	105412943	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr14:105412943C>T	ENST00000333244.5	-	7	8964	c.8845G>A	c.(8845-8847)Gag>Aag	p.E2949K	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2949						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CTCGGGGCCTCGACGTCCACC	0.627000													20	223					0	0	1	0	0
MFI2	4241	broad.mit.edu	37	3	196749847	196749847	+	Missense_Mutation	SNP	C	C	T	rs147201042	byFrequency	TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:196749847C>T	ENST00000296350.5	-	5	738	c.625G>A	c.(625-627)Gac>Aac	p.D209N	MFI2_ENST00000296351.4_Missense_Mutation_p.D209N	NM_005929.5	NP_005920.2	P08582	TRFM_HUMAN	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	209	Transferrin-like 1.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|prostate(1)	20	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)		CCGCTGTAGTCGTAGTATCTC	0.632000													4	65					0	0	1	0	0
IGHG3	3502	broad.mit.edu	37	14	106237688	106237688	+	RNA	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr14:106237688G>A	ENST00000390551.2	-	0	54																											TGTGCCCCCAGAGGTGCTCCT	0.667000													4	21					0	0	1	0	0
ZBTB8A	653121	broad.mit.edu	37	1	33058612	33058612	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:33058612G>A	ENST00000373510.4	+	3	309	c.80G>A	c.(79-81)aGt>aAt	p.S27N	RP1-27O5.3_ENST00000480336.1_3'UTR|ZBTB8A_ENST00000316459.4_Missense_Mutation_p.S27N	NM_001040441.1	NP_001035531.1	Q96BR9	ZBT8A_HUMAN	zinc finger and BTB domain containing 8A	27	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(2)|large_intestine(2)|lung(2)|prostate(1)	7						TGTGACTGCAGTATTCTAGTT	0.433000													8	66					0	0	1	0	0
FAM101B	359845	broad.mit.edu	37	17	293246	293246	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr17:293246G>T	ENST00000329099.4	-	2	143	c.144C>A	c.(142-144)ttC>ttA	p.F48L		NM_182705.2	NP_874364.1	Q8N5W9	F101B_HUMAN	family with sequence similarity 101, member B	118	Poly-Gly.									breast(1)|endometrium(3)|large_intestine(2)|lung(4)|prostate(1)|stomach(1)|urinary_tract(1)	13		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.0216)		CGTCGTCGATGAAGTGCCTCT	0.662000													4	39					1	1	1	1	0
IKBKE	9641	broad.mit.edu	37	1	206651598	206651598	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:206651598G>T	ENST00000367120.3	+	9	1281	c.908G>T	c.(907-909)aGt>aTt	p.S303I	IKBKE_ENST00000537984.1_Missense_Mutation_p.S218I	NM_001193322.1|NM_014002.3	NP_001180251.1|NP_054721.1	Q14164	IKKE_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	303	Protein kinase.				DNA damage response, signal transduction resulting in induction of apoptosis|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane|PML body	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(13)|ovary(3)|skin(2)	32	Breast(84;0.137)					GCGGAGACCAGTGACATCCTG	0.612000													4	53					0.00024832	0.000262414	1	1	0
AP2M1	1173	broad.mit.edu	37	3	183901286	183901286	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:183901286C>G	ENST00000382456.3	+	11	1498	c.1184C>G	c.(1183-1185)tCt>tGt	p.S395C	EIF2B5_ENST00000444495.1_Intron|AP2M1_ENST00000411763.2_Missense_Mutation_p.S422C|AP2M1_ENST00000292807.5_Missense_Mutation_p.S397C|AP2M1_ENST00000439647.1_Missense_Mutation_p.S395C|AP2M1_ENST00000461733.1_3'UTR	NM_001025205.1	NP_001020376.1	Q96CW1	AP2M1_HUMAN	adaptor-related protein complex 2, mu 1 subunit	397	MHD.				axon guidance|cellular membrane organization|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|clathrin coat of coated pit|cytosol|endocytic vesicle membrane|peroxisomal membrane	lipid binding|protein binding|transporter activity			endometrium(1)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(1)	18	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.92e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TTCGCGCCCTCTGGCCTCAAG	0.557000													5	41					0	0	1	0	0
LRRFIP1	9208	broad.mit.edu	37	2	238664806	238664806	+	Silent	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:238664806G>A	ENST00000244815.5	+	8	891	c.651G>A	c.(649-651)ctG>ctA	p.L217L	LRRFIP1_ENST00000392000.4_Silent_p.L241L|LRRFIP1_ENST00000289175.6_Silent_p.L185L|LRRFIP1_ENST00000308482.9_Silent_p.L369L	NM_004735.3	NP_004726.2	Q32MZ4	LRRF1_HUMAN	leucine rich repeat (in FLII) interacting protein 1	241					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|cytoskeleton|nucleus	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	29		Breast(86;0.00257)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;9.75e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.01e-10)|Kidney(56;4.85e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.31e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000151)|Lung(119;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0325)|COAD - Colon adenocarcinoma(134;0.228)		AGGAGGCCCTGAAGCAAAGAG	0.428000													3	52					0	0	1	0	0
SLC25A1	6576	broad.mit.edu	37	22	19163736	19163736	+	Silent	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr22:19163736G>A	ENST00000215882.5	-	9	999	c.843C>T	c.(841-843)ccC>ccT	p.P281P	SLC25A1_ENST00000451283.1_Silent_p.P178P	NM_005984.3	NP_005975.1	P53007	TXTP_HUMAN	solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1	281					gluconeogenesis|long-chain fatty-acyl-CoA biosynthetic process|mitochondrial citrate transport|triglyceride biosynthetic process	integral to membrane|mitochondrial inner membrane	citrate transmembrane transporter activity|protein binding			cervix(1)|lung(1)	2	Colorectal(54;0.0993)	all_lung(157;9.94e-09)		Lung(27;0.124)		GGCCCAGGCGGGGGACAGTGC	0.572000													4	61					0	0	1	0	0
TCF25	22980	broad.mit.edu	37	16	89965049	89965049	+	Silent	SNP	C	C	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr16:89965049C>A	ENST00000263346.8	+	10	1163	c.1107C>A	c.(1105-1107)ctC>ctA	p.L369L	TCF25_ENST00000263347.7_Silent_p.L134L	NM_014972.2	NP_055787.1	Q9BQ70	TCF25_HUMAN	transcription factor 25 (basic helix-loop-helix)	369					heart development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|large_intestine(1)|lung(8)|ovary(3)|skin(1)|urinary_tract(2)	18		all_cancers(9;4.71e-08)|Lung NSC(15;0.000192)|all_lung(18;0.000319)|all_neural(9;0.0122)|all_hematologic(23;0.027)		BRCA - Breast invasive adenocarcinoma(80;0.0288)		ACTGCAAGCTCATCCTGAGGT	0.607000													13	56					1.5842e-08	1.73995e-08	1	1	0
PHYHD1	254295	broad.mit.edu	37	9	131702737	131702737	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr9:131702737G>C	ENST00000372592.3	+	10	1480	c.547G>C	c.(547-549)Gag>Cag	p.E183Q	PHYHD1_ENST00000487504.1_3'UTR|PHYHD1_ENST00000308941.5_Missense_Mutation_p.W175C|PHYHD1_ENST00000421063.2_Missense_Mutation_p.E162Q|PHYHD1_ENST00000353176.5_Missense_Mutation_p.E162Q	NM_001100876.1	NP_001094346.1			phytanoyl-CoA dioxygenase domain containing 1											central_nervous_system(1)|endometrium(2)|large_intestine(3)|skin(1)|stomach(3)	10						TGCCACGCTGGAGAACGGCTG	0.642000													7	48					0	0	1	0	0
CPT1A	1374	broad.mit.edu	37	11	68527753	68527753	+	Silent	SNP	C	C	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr11:68527753C>A	ENST00000265641.5	-	17	2236	c.2082G>T	c.(2080-2082)gtG>gtT	p.V694V	CPT1A_ENST00000376618.2_Silent_p.V694V|CPT1A_ENST00000540367.1_Silent_p.V694V|CPT1A_ENST00000539743.1_Silent_p.V694V	NM_001876.3	NP_001867.2	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A (liver)	694					carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	CAAACAGCTCCACTTGCTGCT	0.562000													37	187					2.59497e-14	2.91561e-14	1	1	0
ZNF197	10168	broad.mit.edu	37	3	44684309	44684309	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:44684309G>C	ENST00000396058.1	+	5	1854	c.1687G>C	c.(1687-1689)Gag>Cag	p.E563Q	RP11-944L7.4_ENST00000457331.1_RNA|ZNF197_ENST00000383745.2_Intron|ZNF197_ENST00000344387.4_Missense_Mutation_p.E563Q|ZNF197_ENST00000383744.4_Intron			O14709	ZN197_HUMAN	zinc finger protein 197	563					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(1)	25				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		CCACAGTGCAGAGAACCCTTA	0.418000													7	116					0	0	1	0	0
MYEOV	26579	broad.mit.edu	37	11	69062897	69062897	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr11:69062897G>T	ENST00000308946.3	+	2	526	c.76G>T	c.(76-78)Gaa>Taa	p.E26*	MYEOV_ENST00000535407.1_5'UTR|MYEOV_ENST00000441339.2_Nonsense_Mutation_p.E26*	NM_138768.2	NP_620123.2	Q96EZ4	MYEOV_HUMAN	myeloma overexpressed	26										endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(1)|lung(12)|prostate(2)|skin(1)|urinary_tract(1)	24	all_lung(4;2.21e-19)|Lung NSC(4;6.13e-19)|Melanoma(5;0.00128)		LUSC - Lung squamous cell carcinoma(11;3.33e-11)|STAD - Stomach adenocarcinoma(18;0.00654)|LUAD - Lung adenocarcinoma(13;0.0713)	Kidney(183;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(183;3.23e-08)|Lung(977;0.00361)|LUSC - Lung squamous cell carcinoma(976;0.0153)		cctctgcctggaacagtctcc	0.592000													8	835					0.0381472	0.0385415	1	1	0
FASTKD5	60493	broad.mit.edu	37	20	3127577	3127577	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr20:3127577G>C	ENST00000380266.3	-	2	2461	c.2140C>G	c.(2140-2142)Ctc>Gtc	p.L714V	UBOX5-AS1_ENST00000446537.1_RNA|UBOX5_ENST00000348031.2_Intron|UBOX5_ENST00000217173.2_Intron	NM_021826.4	NP_068598.1	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	714	RAP.				apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(2)|endometrium(2)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(2)	19						AGTCCAAGGAGATCCCTGGAG	0.552000													13	109					0	0	1	0	0
DCAF8	50717	broad.mit.edu	37	1	160209785	160209785	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:160209785G>A	ENST00000368073.3	-	4	859	c.425C>T	c.(424-426)tCa>tTa	p.S142L	DCAF8_ENST00000610139.1_Missense_Mutation_p.S142L|DCAF8_ENST00000326837.2_Missense_Mutation_p.S142L|DCAF8_ENST00000556710.1_Missense_Mutation_p.S296L|DCAF8_ENST00000368074.1_Missense_Mutation_p.S142L|DCAF8_ENST00000475733.1_Missense_Mutation_p.S142L|DCAF8_ENST00000608310.1_Missense_Mutation_p.S296L			Q5TAQ9	DCAF8_HUMAN	DDB1 and CUL4 associated factor 8	142						CUL4 RING ubiquitin ligase complex	protein binding			cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(16)|skin(3)|upper_aerodigestive_tract(1)	33						TGATGTTTCTGAGGACACCCA	0.627000													9	42					0	0	1	0	0
NXF4	55999	broad.mit.edu	37	X	101818925	101818925	+	RNA	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chrX:101818925G>A	ENST00000360035.2	+	0	1209					NR_002216.1															endometrium(2)|lung(8)	10						GCTATGGCTGGAAGGGAACTC	0.557000													8	59					0	0	1	0	0
CHIT1	1118	broad.mit.edu	37	1	203194885	203194885	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:203194885C>T	ENST00000367229.1	-	3	203	c.169G>A	c.(169-171)Gcc>Acc	p.A57T	CHIT1_ENST00000535569.1_Missense_Mutation_p.A67T|CHIT1_ENST00000255427.3_Missense_Mutation_p.A57T|CHIT1_ENST00000484834.1_5'UTR	NM_001270509.1|NM_003465.2	NP_001257438.1|NP_003456.1	Q13231	CHIT1_HUMAN	chitinase 1 (chitotriosidase)	57					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|stomach(2)	27						CCAGCGAAGGCGTAGATGAGG	0.572000													3	30					0	0	1	0	0
ITLN2	142683	broad.mit.edu	37	1	160920349	160920349	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:160920349G>C	ENST00000368029.3	-	5	651	c.594C>G	c.(592-594)atC>atG	p.I198M	ITLN2_ENST00000494442.1_5'UTR	NM_080878.2	NP_543154.1	Q8WWU7	ITLN2_HUMAN	intelectin 2	198	Fibrinogen C-terminal.				signal transduction	extracellular region	receptor binding|sugar binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	19	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GTACCTGGTAGATGCCAAACA	0.557000													7	213					0	0	1	0	0
NGFRAP1	27018	broad.mit.edu	37	X	102632603	102632603	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chrX:102632603G>A	ENST00000361298.4	+	3	519	c.154G>A	c.(154-156)Gga>Aga	p.G52R	NGFRAP1_ENST00000372634.1_Missense_Mutation_p.G52R|NGFRAP1_ENST00000372635.1_Missense_Mutation_p.G62R|NGFRAP1_ENST00000372645.3_Missense_Mutation_p.G62R|NGFRAP1_ENST00000299872.7_Missense_Mutation_p.G62R	NM_206915.1|NM_206917.1	NP_996798.1|NP_996800.1	Q00994	BEX3_HUMAN	nerve growth factor receptor (TNFRSF16) associated protein 1	62					apoptosis|multicellular organismal development|nerve growth factor receptor signaling pathway	cytosol|nucleus	caspase regulator activity|metal ion binding			NS(2)|endometrium(1)|large_intestine(2)|lung(4)|urinary_tract(1)	10						TGGGATGGGTGGAGATGGAGA	0.498000													10	377					0	0	1	0	0
PCDHGB4	8641	broad.mit.edu	37	5	140768264	140768264	+	Silent	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr5:140768264G>A	ENST00000519479.1	+	1	813	c.813G>A	c.(811-813)gaG>gaA	p.E271E	PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron	NM_003736.2|NM_018925.2|NM_032098.1	NP_003727.1|NP_061748.1|NP_115269.1														endometrium(9)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(2)	37			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCAGGATGAGGGTGTCAATG	0.483000													5	71					0	0	1	0	0
LOC653786	653786	broad.mit.edu	37	16	22588015	22588015	+	RNA	SNP	A	A	G	rs460493	by1000genomes	TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr16:22588015A>G	ENST00000550753.1	+	0	2490					NR_003676.2																						TGGCCTGAGCACATCGTCCTG	0.557000													4	50					0	0	1	0	0
PPIG	9360	broad.mit.edu	37	2	170493734	170493734	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:170493734G>C	ENST00000260970.3	+	14	2186	c.1966G>C	c.(1966-1968)Gaa>Caa	p.E656Q	PPIG_ENST00000409714.3_Missense_Mutation_p.E641Q|PPIG_ENST00000448752.2_Missense_Mutation_p.E656Q	NM_004792.2	NP_004783.2	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G (cyclophilin G)	656					protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(17)|ovary(2)|stomach(1)|urinary_tract(1)	43					L-Proline(DB00172)	ACACAGAAAAGAAAATTCTGA	0.393000													7	46					0	0	1	0	0
KDM4B	23030	broad.mit.edu	37	19	5071030	5071030	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:5071030C>G	ENST00000159111.4	+	7	854	c.636C>G	c.(634-636)atC>atG	p.I212M	KDM4B_ENST00000536461.1_Missense_Mutation_p.I212M|KDM4B_ENST00000592175.1_3'UTR|KDM4B_ENST00000381759.4_Missense_Mutation_p.I212M	NM_015015.2	NP_055830	O94953	KDM4B_HUMAN	lysine (K)-specific demethylase 4B	212	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(1)|liver(1)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						GGTACGCCATCCCACCAGAGC	0.692000													3	19					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126412188	126412188	+	Silent	SNP	C	C	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr4:126412188C>A	ENST00000394329.3	+	17	14224	c.14211C>A	c.(14209-14211)acC>acA	p.T4737T	FAT4_ENST00000335110.5_Silent_p.T2978T	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4737					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						ATGGTGACACCTGCCAACCTG	0.483000													11	52					2.80697e-09	3.10914e-09	1	1	0
IL21	59067	broad.mit.edu	37	4	123534024	123534024	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr4:123534024G>C	ENST00000264497.3	-	4	477	c.420C>G	c.(418-420)ttC>ttG	p.F140L		NM_001207006.2|NM_021803.3	NP_001193935.1|NP_068575.1	Q9HBE4	IL21_HUMAN	interleukin 21	133					cell maturation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-17 production|positive regulation of T cell proliferation|signal transduction	extracellular space	cytokine activity|interleukin-2 receptor binding			NS(1)|kidney(1)|large_intestine(2)|liver(1)|lung(3)	8						GAAGTGATTTGAATCTTTCTA	0.313000													5	28					0	0	1	0	0
CLIP3	25999	broad.mit.edu	37	19	36515504	36515504	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:36515504C>T	ENST00000360535.4	-	7	939	c.712G>A	c.(712-714)Gtc>Atc	p.V238I	CLIP3_ENST00000593074.1_Missense_Mutation_p.V238I|AC002116.7_ENST00000586962.1_RNA	NM_015526.2	NP_056341.1	Q96DZ5	CLIP3_HUMAN	CAP-GLY domain containing linker protein 3	238					chaperone-mediated protein transport|fat cell differentiation|membrane biogenesis|negative regulation of microtubule polymerization|peptidyl-L-cysteine S-palmitoylation|positive regulation of apoptosis|positive regulation of endocytosis|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose transport|positive regulation of protein phosphorylation	early endosome membrane|Golgi stack|membrane raft|microsome|plasma membrane|recycling endosome membrane|trans-Golgi network membrane	ganglioside binding|microtubule binding			cervix(1)|endometrium(6)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	23	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GGATCTGGGACCACCTCCGCC	0.627000													9	36					0	0	1	0	0
SYCP2	10388	broad.mit.edu	37	20	58489040	58489040	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr20:58489040C>T	ENST00000357552.3	-	12	1045	c.820G>A	c.(820-822)Gac>Aac	p.D274N	SYCP2_ENST00000371001.2_Missense_Mutation_p.D274N			Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	274					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			CTTCTTTTGTCTCCAAGCATG	0.294000													11	35					0	0	1	0	0
NRK	203447	broad.mit.edu	37	X	105159728	105159728	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chrX:105159728G>C	ENST00000428173.2	+	15	2662	c.2359G>C	c.(2359-2361)Gag>Cag	p.E787Q	NRK_ENST00000243300.9_Missense_Mutation_p.E786Q			Q7Z2Y5	NRK_HUMAN	Nik related kinase	786							ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						TAAGGTTCAAGAGAGATCTCC	0.328000										HNSCC(51;0.14)			7	71					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8665949	8665949	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:8665949C>G	ENST00000270328.4	-	5	939	c.673G>C	c.(673-675)Gag>Cag	p.E225Q	ADAMTS10_ENST00000597188.1_Missense_Mutation_p.E225Q|ADAMTS10_ENST00000596709.1_5'UTR			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	225					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						TGGCCACGCTCTGTTTCATTC	0.642000													3	45					0	0	1	0	0
E2F4	1874	broad.mit.edu	37	16	67232012	67232012	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr16:67232012G>C	ENST00000379378.3	+	10	1287	c.1228G>C	c.(1228-1230)Gtt>Ctt	p.V410L		NM_001950.3	NP_001941.2	Q16254	E2F4_HUMAN	E2F transcription factor 4, p107/p130-binding	410	Transactivation (Potential).				G1 phase of mitotic cell cycle	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			breast(4)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)	11		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000697)|Epithelial(162;0.00303)|all cancers(182;0.0325)		TGATGTGCCTGTTCTCAACCT	0.582000											OREG0023875	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	108					0	0	1	0	0
GOT1L1	137362	broad.mit.edu	37	8	37797455	37797455	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr8:37797455G>T	ENST00000307599.4	-	1	192	c.93C>A	c.(91-93)aaC>aaA	p.N31K		NM_152413.2	NP_689626.2	Q8NHS2	AATC2_HUMAN	glutamic-oxaloacetic transaminase 1-like 1	31					biosynthetic process|cellular amino acid metabolic process	cytoplasm	pyridoxal phosphate binding|transaminase activity			central_nervous_system(1)|endometrium(3)|lung(8)|ovary(1)|prostate(1)	14	Colorectal(12;0.00627)	Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;1.37e-11)			AGAATATCTTGTTCGGGTAAT	0.463000													3	16					0.115264	0.115857	1	1	0
GOLGB1	2804	broad.mit.edu	37	3	121395812	121395812	+	Silent	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:121395812G>C	ENST00000393667.3	-	17	9215	c.9105C>G	c.(9103-9105)ctC>ctG	p.L3035L	GOLGB1_ENST00000340645.5_Silent_p.L3030L	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	3030					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		GCTGGGTCCTGAGAAGTTCTG	0.438000													4	49					0	0	1	0	0
TET3	200424	broad.mit.edu	37	2	74328835	74328835	+	Silent	SNP	G	G	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:74328835G>T	ENST00000409262.3	+	9	4515	c.4515G>T	c.(4513-4515)tcG>tcT	p.S1505S		NM_144993.1	NP_659430.1	O43151	TET3_HUMAN	tet methylcytosine dioxygenase 3	1505							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						AGCTGTGGTCGGACAGTGAAC	0.687000													8	71					0.00307968	0.00317719	1	1	0
KHDRBS1	10657	broad.mit.edu	37	1	32498934	32498934	+	Splice_Site	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:32498934C>T	ENST00000327300.7	+	4	937	c.770C>T	c.(769-771)cCg>cTg	p.P257L	KHDRBS1_ENST00000307714.8_3'UTR|KHDRBS1_ENST00000492989.1_Splice_Site_p.P218L	NM_006559.1	NP_006550.1	Q07666	KHDR1_HUMAN	KH domain containing, RNA binding, signal transduction associated 1	257					cell cycle arrest|cell proliferation|cell surface receptor linked signaling pathway|G2/M transition of mitotic cell cycle|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of RNA export from nucleus|transcription, DNA-dependent	membrane|nucleus	DNA binding|RNA binding|SH3 domain binding|SH3/SH2 adaptor activity			endometrium(4)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)	14		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TTTCTAGTACCGGTAAGGAAA	0.433000													8	79					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35453089	35453089	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr8:35453089G>C	ENST00000287272.2	+	4	504	c.484G>C	c.(484-486)Gaa>Caa	p.E162Q	UNC5D_ENST00000420357.1_Missense_Mutation_p.E162Q|UNC5D_ENST00000416672.1_Missense_Mutation_p.E162Q|UNC5D_ENST00000453357.2_Missense_Mutation_p.E157Q|UNC5D_ENST00000404895.2_Missense_Mutation_p.E162Q			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	162	Ig-like C2-type.				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		GAAAAACTTTGAACAAGACCC	0.453000													14	83					0	0	1	0	0
PPIL6	285755	broad.mit.edu	37	6	109714030	109714030	+	Nonstop_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr6:109714030C>G	ENST00000521072.2	-	8	1515	c.935G>C	c.(934-936)tGa>tCa	p.*312S	PPIL6_ENST00000440797.2_Nonstop_Mutation_p.*338S|PPIL6_ENST00000424445.2_Nonstop_Mutation_p.*280S	NM_173672.4	NP_775943.1	Q8IXY8	PPIL6_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 6	0					protein folding		peptidyl-prolyl cis-trans isomerase activity			large_intestine(3)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6		all_cancers(87;1.1e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000144)|all_lung(197;0.0221)|Colorectal(196;0.0488)|Lung SC(18;0.0548)		Epithelial(106;0.00684)|BRCA - Breast invasive adenocarcinoma(108;0.00889)|all cancers(137;0.0106)|OV - Ovarian serous cystadenocarcinoma(136;0.0259)		ATATGAAAATCAAGCATAAGG	0.294000													6	44					0	0	1	0	0
CDKAL1	54901	broad.mit.edu	37	6	21231200	21231200	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr6:21231200C>T	ENST00000274695.4	+	16	1837	c.1670C>T	c.(1669-1671)gCg>gTg	p.A557V	CDKAL1_ENST00000476517.1_3'UTR|CDKAL1_ENST00000378610.1_Missense_Mutation_p.A557V|CDKAL1_ENST00000378624.4_Missense_Mutation_p.A466V	NM_017774.3	NP_060244.2	Q5VV42	CDKAL_HUMAN	CDK5 regulatory subunit associated protein 1-like 1	557					RNA modification	integral to membrane	4 iron, 4 sulfur cluster binding|metal ion binding|transferase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|stomach(1)	29	all_epithelial(95;0.0708)|Breast(50;0.131)|Ovarian(93;0.227)		OV - Ovarian serous cystadenocarcinoma(7;0.0241)|all cancers(50;0.123)|Epithelial(50;0.248)			CAAGACTGTGCGCTGAGGATG	0.468000													7	37					0	0	1	0	0
ZNF780B	163131	broad.mit.edu	37	19	40541682	40541682	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:40541682C>G	ENST00000434248.1	-	5	1149	c.1084G>C	c.(1084-1086)Gaa>Caa	p.E362Q	ZNF780B_ENST00000221355.6_Missense_Mutation_p.E214Q	NM_001005851.2	NP_001005851.1	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	362					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TCCCTGCATTCAAAGGGCTTC	0.418000													6	105					0	0	1	0	0
PLCG2	5336	broad.mit.edu	37	16	81929465	81929465	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr16:81929465C>G	ENST00000359376.3	+	13	1340	c.1126C>G	c.(1126-1128)Cgg>Ggg	p.R376G		NM_002661.3	NP_002652.2	P16885	PLCG2_HUMAN	phospholipase C, gamma 2 (phosphatidylinositol-specific)	376	PI-PLC X-box.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(18)|lung(21)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	58						TGGCTGGACGCGGACTACCAA	0.562000													4	88					0	0	1	0	0
UBA5	79876	broad.mit.edu	37	3	132394685	132394685	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:132394685C>T	ENST00000356232.4	+	11	2121	c.1049C>T	c.(1048-1050)tCa>tTa	p.S350L	UBA5_ENST00000494238.2_Missense_Mutation_p.S294L|UBA5_ENST00000473651.1_Intron|UBA5_ENST00000493720.2_Missense_Mutation_p.S350L|UBA5_ENST00000264991.4_Missense_Mutation_p.S294L	NM_024818.3	NP_079094.1	Q9GZZ9	UBA5_HUMAN	ubiquitin-like modifier activating enzyme 5	350					protein ufmylation	aggresome|cytoplasm|nucleus	ATP binding|cofactor binding|metal ion binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding|UFM1 activating enzyme activity			breast(2)|endometrium(4)|kidney(4)|large_intestine(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16						TCTGAGGTTTCAGAAGAGGAA	0.308000													3	24					0	0	1	0	0
ZBTB41	360023	broad.mit.edu	37	1	197128764	197128764	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:197128764C>T	ENST00000367405.4	-	10	2523	c.2455G>A	c.(2455-2457)Gac>Aac	p.D819N	ZBTB41_ENST00000467322.1_5'UTR	NM_194314.2	NP_919290.2	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	819					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(11)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	40						CTCGGAGTGTCAGGCATCTGA	0.488000													24	45					0	0	1	0	0
KDM5B	10765	broad.mit.edu	37	1	202711820	202711820	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:202711820C>G	ENST00000367265.3	-	17	3601	c.2437G>C	c.(2437-2439)Gtt>Ctt	p.V813L	KDM5B_ENST00000367264.2_Missense_Mutation_p.V849L	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	813					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						TGCTGCGCAACAGAGGCACAC	0.448000													11	92					0	0	1	0	0
ZNF582	147948	broad.mit.edu	37	19	56896194	56896194	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:56896194G>A	ENST00000301310.4	-	5	750	c.592C>T	c.(592-594)Ccc>Tcc	p.P198S	ZNF582_ENST00000586929.1_Missense_Mutation_p.P198S	NM_144690.1	NP_653291.1	Q96NG8	ZN582_HUMAN	zinc finger protein 582	198					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)		CATTTATAGGGTTTCTCATTA	0.323000													5	70					0	0	1	0	0
PRC1	9055	broad.mit.edu	37	15	91537642	91537642	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr15:91537642C>G	ENST00000361188.5	-	1	1217	c.6G>C	c.(4-6)agG>agC	p.R2S	PRC1_ENST00000361919.3_Missense_Mutation_p.R2S|PRC1_ENST00000394249.3_Missense_Mutation_p.R2S|PRC1_ENST00000442656.2_Missense_Mutation_p.R2S|PRC1_ENST00000556129.1_5'UTR			O43663	PRC1_HUMAN	protein regulator of cytokinesis 1	2	Dimerization.				cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			endometrium(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(3)|prostate(1)|skin(2)	25	Lung NSC(78;0.0987)|all_lung(78;0.175)					CGCACCTTCTCCTCATGGCGG	0.682000													8	42					0	0	1	0	0
FRMD7	90167	broad.mit.edu	37	X	131212726	131212726	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chrX:131212726C>T	ENST00000298542.4	-	12	1494	c.1319G>A	c.(1318-1320)aGg>aAg	p.R440K	FRMD7_ENST00000370879.1_Missense_Mutation_p.R320K|FRMD7_ENST00000464296.1_Missense_Mutation_p.R425K	NM_194277.2	NP_919253.1	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	440					regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Acute lymphoblastic leukemia(192;0.000127)					TAGAGAACTCCTCTCTGAAAA	0.438000													23	102					0	0	1	0	0
SH3KBP1	30011	broad.mit.edu	37	X	19554542	19554542	+	Nonsense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chrX:19554542G>C	ENST00000397821.3	-	18	2281	c.1991C>G	c.(1990-1992)tCa>tGa	p.S664*	SH3KBP1_ENST00000379716.1_Nonsense_Mutation_p.S426*|SH3KBP1_ENST00000541422.1_Nonsense_Mutation_p.S403*|SH3KBP1_ENST00000379698.4_Nonsense_Mutation_p.S627*	NM_031892.2	NP_114098.1	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1	664					apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|skin(4)	29						TATTCATTTTGATTGTAGAGC	0.338000													17	78					0	0	1	0	0
ZNF654	55279	broad.mit.edu	37	3	88189890	88189890	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:88189890C>T	ENST00000309495.5	+	1	1637	c.1430C>T	c.(1429-1431)tCt>tTt	p.S477F	CGGBP1_ENST00000462901.1_Intron	NM_018293.2	NP_060763.2	Q8IZM8	ZN654_HUMAN	zinc finger protein 654	477					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|large_intestine(2)|lung(1)|ovary(2)|pancreas(1)|prostate(3)	12		Lung NSC(201;0.0283)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		TTGCCAGTATCTCAGGCACCT	0.403000													13	102					0	0	1	0	0
KLHL6	89857	broad.mit.edu	37	3	183226087	183226087	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:183226087C>A	ENST00000341319.3	-	3	704	c.669G>T	c.(667-669)aaG>aaT	p.K223N		NM_130446.2	NP_569713.2	Q8WZ60	KLHL6_HUMAN	kelch-like family member 6	223	BACK.									breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			ggtcatcactcttcaagatgt	0.502000													5	65					5.9392e-07	6.39732e-07	1	1	0
RGS3	5998	broad.mit.edu	37	9	116299150	116299150	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr9:116299150G>C	ENST00000374140.2	+	20	2198	c.1989G>C	c.(1987-1989)gaG>gaC	p.E663D	RGS3_ENST00000343817.5_Missense_Mutation_p.E382D|RGS3_ENST00000317613.6_Missense_Mutation_p.E551D|RGS3_ENST00000462143.1_5'UTR|RGS3_ENST00000350696.5_Missense_Mutation_p.E663D|RGS3_ENST00000394646.3_Missense_Mutation_p.E382D|RGS3_ENST00000374136.1_Missense_Mutation_p.E289D	NM_001282923.1|NM_144488.4	NP_001269852.1|NP_652759.3	P49796	RGS3_HUMAN	regulator of G-protein signaling 3	663					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			cervix(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	48						GCCTGTCGGAGAACATCGCCA	0.572000													16	33					0	0	1	0	0
B4GALNT1	2583	broad.mit.edu	37	12	58020596	58020596	+	Silent	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr12:58020596G>A	ENST00000341156.4	-	11	2117	c.1533C>T	c.(1531-1533)gaC>gaT	p.D511D	B4GALNT1_ENST00000418555.2_Silent_p.D456D	NM_001478.3	NP_001469.1	Q00973	B4GN1_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 1	511					lipid glycosylation	integral to Golgi membrane|membrane fraction	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)|urinary_tract(1)	20	Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			TCTGGCTCTCGTCCAGTGATC	0.577000													8	115					0	0	1	0	0
MYEOV	26579	broad.mit.edu	37	11	69062935	69062935	+	Silent	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr11:69062935G>C	ENST00000308946.3	+	2	564	c.114G>C	c.(112-114)gtG>gtC	p.V38V	MYEOV_ENST00000535407.1_5'UTR|MYEOV_ENST00000441339.2_Silent_p.V38V	NM_138768.2	NP_620123.2	Q96EZ4	MYEOV_HUMAN	myeloma overexpressed	38										endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(1)|lung(12)|prostate(2)|skin(1)|urinary_tract(1)	24	all_lung(4;2.21e-19)|Lung NSC(4;6.13e-19)|Melanoma(5;0.00128)		LUSC - Lung squamous cell carcinoma(11;3.33e-11)|STAD - Stomach adenocarcinoma(18;0.00654)|LUAD - Lung adenocarcinoma(13;0.0713)	Kidney(183;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(183;3.23e-08)|Lung(977;0.00361)|LUSC - Lung squamous cell carcinoma(976;0.0153)		TCCGTGGTGTGTCCTTCCTGA	0.567000													11	1322					0	0	1	0	0
EFCAB12	90288	broad.mit.edu	37	3	129137244	129137244	+	Silent	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:129137244C>T	ENST00000505956.1	-	3	696	c.534G>A	c.(532-534)caG>caA	p.Q178Q	EFCAB12_ENST00000326085.3_Silent_p.Q178Q	NM_207307.1	NP_997190.1			EF-hand calcium binding domain 12																		GCAGCTGGAGCTGGGGCACCA	0.607000													5	17					0	0	1	0	0
GLRA3	8001	broad.mit.edu	37	4	175580279	175580279	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr4:175580279C>T	ENST00000274093.3	-	8	1499	c.997G>A	c.(997-999)Gag>Aag	p.E333K	GLRA3_ENST00000340217.5_Missense_Mutation_p.E333K	NM_006529.2	NP_006520.2	O75311	GLRA3_HUMAN	glycine receptor, alpha 3	333					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			endometrium(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	35		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	GCTGCATACTCCAGAAGTGCT	0.368000													9	59					0	0	1	0	0
FBXO34	55030	broad.mit.edu	37	14	55818418	55818418	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr14:55818418G>C	ENST00000313833.4	+	2	1555	c.1310G>C	c.(1309-1311)aGa>aCa	p.R437T	FBXO34_ENST00000440021.1_Missense_Mutation_p.R437T	NM_017943.3	NP_060413.2	Q9NWN3	FBX34_HUMAN	F-box protein 34	437								p.R437I(1)		breast(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(3)	22						TGTATGAGCAGAGAGCTTGTG	0.433000													13	107					0	0	1	0	0
VPS8	23355	broad.mit.edu	37	3	184700418	184700418	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:184700418C>T	ENST00000437079.3	+	41	3656	c.3485C>T	c.(3484-3486)cCt>cTt	p.P1162L	VPS8_ENST00000446204.2_Missense_Mutation_p.P1070L|VPS8_ENST00000287546.4_Missense_Mutation_p.P1162L|VPS8_ENST00000436792.2_Missense_Mutation_p.P1160L	NM_001009921.2	NP_001009921.1	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog (S. cerevisiae)	1162							zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			TCAGCCATTCCTCATCTACAC	0.398000													3	32					0	0	1	0	0
KANSL1	284058	broad.mit.edu	37	17	44110783	44110783	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr17:44110783C>T	ENST00000262419.6	-	12	3180	c.2710G>A	c.(2710-2712)Gag>Aag	p.E904K	KANSL1_ENST00000575318.1_Missense_Mutation_p.E840K|KANSL1_ENST00000574590.1_Missense_Mutation_p.E904K|KANSL1_ENST00000432791.1_Missense_Mutation_p.E904K|KANSL1_ENST00000572904.1_Missense_Mutation_p.E904K|KANSL1_ENST00000393476.3_Missense_Mutation_p.E198K	NM_001193466.1	NP_001180395	Q7Z3B3	K1267_HUMAN	KAT8 regulatory NSL complex subunit 1	904						MLL1 complex	protein binding										TCATTCTCCTCATCAGGACTC	0.488000													7	64					0	0	1	0	0
DDX20	11218	broad.mit.edu	37	1	112302068	112302068	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:112302068C>T	ENST00000369702.4	+	3	1063	c.443C>T	c.(442-444)tCt>tTt	p.S148F	DDX20_ENST00000536167.1_Intron	NM_007204.4	NP_009135.4	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	148	Helicase ATP-binding.				assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			endometrium(3)|kidney(7)|large_intestine(6)|lung(3)|pancreas(1)|prostate(1)	21		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAGATACATTCTGTTATTACA	0.353000													18	52					0	0	1	0	0
SPAG16	79582	broad.mit.edu	37	2	214794779	214794779	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:214794779G>A	ENST00000331683.5	+	12	1405	c.1310G>A	c.(1309-1311)cGc>cAc	p.R437H	SPAG16_ENST00000374309.3_Missense_Mutation_p.R343H	NM_024532.4	NP_078808.3	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16	437					cilium assembly	cilium axoneme|flagellar axoneme				endometrium(4)|kidney(1)|large_intestine(15)|lung(27)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	56		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		GGACACAGCCGCGCAGTGTGG	0.438000													5	63					0	0	1	0	0
PLEKHG7	440107	broad.mit.edu	37	12	93162806	93162806	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr12:93162806C>T	ENST00000344636.3	+	11	1166	c.982C>T	c.(982-984)Cga>Tga	p.R328*		NM_001004330.2	NP_001004330.1	Q6ZR37	PKHG7_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 7	328	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)	17						AAACAGATATCGACAGTGTAT	0.318000													9	100					0	0	1	0	0
LAD1	3898	broad.mit.edu	37	1	201355807	201355807	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:201355807C>G	ENST00000391967.2	-	3	983	c.682G>C	c.(682-684)Gag>Cag	p.E228Q	LAD1_ENST00000367313.3_Missense_Mutation_p.E242Q	NM_005558.3	NP_005549.2	O00515	LAD1_HUMAN	ladinin 1	228	8 X SEK repeats.					basement membrane	structural molecule activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|prostate(2)|skin(2)	19						GACTTCTTCTCTGAGCTGTTT	0.502000													11	105					0	0	1	0	0
YARS	8565	broad.mit.edu	37	1	33256819	33256819	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:33256819G>C	ENST00000373477.4	-	6	1536	c.628C>G	c.(628-630)Ctg>Gtg	p.L210V		NM_003680.3	NP_003671.1	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	210					apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|skin(2)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	GGATTCATCAGATGGACCCGT	0.443000													12	170					0	0	1	0	0
VSIG10	54621	broad.mit.edu	37	12	118533470	118533470	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr12:118533470C>A	ENST00000359236.5	-	2	505	c.229G>T	c.(229-231)Gag>Tag	p.E77*	VSIG10_ENST00000536905.1_5'UTR	NM_019086.5	NP_061959.2	Q8N0Z9	VSI10_HUMAN	V-set and immunoglobulin domain containing 10	77	Ig-like C2-type 1.					integral to membrane				endometrium(5)|large_intestine(3)|lung(6)|skin(1)|stomach(1)|urinary_tract(1)	17						AAGCGAGGCTCAGCTGGCCGG	0.582000													3	18					0.004672	0.00476959	1	1	0
ANKRD28	23243	broad.mit.edu	37	3	15762520	15762520	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:15762520C>T	ENST00000399451.2	-	8	1175	c.808G>A	c.(808-810)Gaa>Aaa	p.E270K	ANKRD28_ENST00000383777.1_Missense_Mutation_p.E303K|ANKRD28_ENST00000497037.1_5'UTR	NM_001195098.1|NM_001195099.1|NM_015199.3	NP_001182027.1|NP_001182028.1|NP_056014.2	O15084	ANR28_HUMAN	ankyrin repeat domain 28	270						nucleoplasm	protein binding			breast(2)|endometrium(1)|large_intestine(2)|prostate(1)	6						AATCCTTTTTCATTCTTTTGA	0.403000													13	132					0	0	1	0	0
ERP44	23071	broad.mit.edu	37	9	102814809	102814809	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr9:102814809C>T	ENST00000262455.6	-	4	375	c.176G>A	c.(175-177)cGt>cAt	p.R59H		NM_015051.1	NP_055866.1	Q9BS26	ERP44_HUMAN	endoplasmic reticulum protein 44	59	Thioredoxin.				cell redox homeostasis|glycoprotein metabolic process|protein folding|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|ER-Golgi intermediate compartment	protein binding|protein disulfide isomerase activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|prostate(2)	19						CTGACTGAAACGACACCTATA	0.353000													4	40					0	0	1	0	0
HNRNPUL2	221092	broad.mit.edu	37	11	62488883	62488883	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr11:62488883C>T	ENST00000301785.5	-	9	1687	c.1495G>A	c.(1495-1497)Gag>Aag	p.E499K	HNRNPUL2-BSCL2_ENST00000403734.2_Missense_Mutation_p.E499K	NM_001079559.2	NP_001073027.1	Q1KMD3	HNRL2_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 2	499					cell killing	nucleus	ATP binding|nucleic acid binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						TCTGGCTCCTCGAGACCCTTC	0.438000													40	93					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155505986	155505986	+	Splice_Site	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr4:155505986C>G	ENST00000302053.3	-	6	1970		c.e6-1			NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain						platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TCATCACAGTCTAAAAAAAAA	0.363000													3	64					0	0	1	0	0
ABCB10	23456	broad.mit.edu	37	1	229667406	229667406	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:229667406C>T	ENST00000344517.4	-	7	1454	c.1412G>A	c.(1411-1413)aGa>aAa	p.R471K		NM_012089.2	NP_036221.2	Q9NRK6	ABCBA_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 10	471			R -> T (in a breast cancer sample; somatic mutation).			integral to mitochondrial membrane|mitochondrial inner membrane	ATP binding|oligopeptide-transporting ATPase activity	p.R471T(1)		breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)	31	Breast(184;0.143)|Ovarian(103;0.249)	Prostate(94;0.167)				CTTGGGCTCTCTCTCCAGGAG	0.517000													16	35					0	0	1	0	0
BLM	641	broad.mit.edu	37	15	91328258	91328258	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr15:91328258G>A	ENST00000355112.3	+	14	2888	c.2770G>A	c.(2770-2772)Gat>Aat	p.D924N	BLM_ENST00000560136.1_3'UTR|BLM_ENST00000560509.1_Missense_Mutation_p.D924N	NM_000057.2	NP_000048.1	P54132	BLM_HUMAN	Bloom syndrome, RecQ helicase-like	924	Helicase C-terminal.				double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(11)|liver(4)|lung(9)|ovary(6)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			TGGCCTCAGTGATTCTGCCAG	0.433000			"""Mis, N, F"""			"""leukemia, lymphoma, skin squamous cell , other cancers"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Bloom syndrome				7	84					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20056234	20056234	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr20:20056234C>G	ENST00000245957.5	+	6	617	c.541C>G	c.(541-543)Cct>Gct	p.P181A	C20orf26_ENST00000377306.1_Missense_Mutation_p.P181A|C20orf26_ENST00000389656.3_5'UTR|C20orf26_ENST00000451767.2_Missense_Mutation_p.P181A|C20orf26_ENST00000377309.2_5'UTR	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	181										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		CAGCCACTATCCTCAGCTGCA	0.483000													13	120					0	0	1	0	0
POMGNT1	55624	broad.mit.edu	37	1	46657836	46657836	+	Silent	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:46657836G>A	ENST00000371992.1	-	17	2123	c.1473C>T	c.(1471-1473)atC>atT	p.I491I	POMGNT1_ENST00000535522.1_Silent_p.I469I|POMGNT1_ENST00000371986.3_Silent_p.I491I|POMGNT1_ENST00000485714.1_5'UTR|POMGNT1_ENST00000396420.3_3'UTR|POMGNT1_ENST00000371984.3_Silent_p.I491I	NM_001243766.1	NP_001230695	Q8WZA1	PMGT1_HUMAN	protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)	491					protein N-linked glycosylation|protein O-linked glycosylation	Golgi membrane|integral to membrane|microsome	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(166;0.155)					CGTCAGGGATGATGCACTCTC	0.567000													4	43					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23904747	23904747	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr13:23904747G>A	ENST00000382298.3	-	10	13856	c.13268C>T	c.(13267-13269)tCa>tTa	p.S4423L	SACS_ENST00000402364.1_Missense_Mutation_p.S3673L|SACS_ENST00000382292.3_Missense_Mutation_p.S4423L	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	4423					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CTGTCCGGCTGAAGGGGGGCA	0.448000													10	113					0	0	1	0	0
BCMO1	53630	broad.mit.edu	37	16	81279132	81279132	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr16:81279132G>A	ENST00000258168.2	+	2	578	c.117G>A	c.(115-117)atG>atA	p.M39I	BCMO1_ENST00000425577.2_Missense_Mutation_p.A14T|BCMO1_ENST00000564552.1_Missense_Mutation_p.M39I	NM_017429.2	NP_059125.2	Q9HAY6	BCDO1_HUMAN	beta-carotene 15,15'-monooxygenase 1	39					retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity			breast(2)|endometrium(1)|large_intestine(4)|lung(9)|prostate(3)|skin(3)|stomach(1)	23						GGCCTGGGATGCACACAGTTG	0.547000													9	83					0	0	1	0	0
FUT1	2523	broad.mit.edu	37	19	49254077	49254077	+	Silent	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:49254077G>A	ENST00000310160.3	-	4	1436	c.462C>T	c.(460-462)taC>taT	p.Y154Y		NM_000148.3	NP_000139.1	P19526	FUT1_HUMAN	fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)	154			Y -> C (in Bombay H-).|Y -> H (in para-Bombay allele H5; dbSNP:rs55678037).		L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to plasma membrane|membrane fraction	galactoside 2-alpha-L-fucosyltransferase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(3)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	17		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000135)|all cancers(93;0.000354)|Epithelial(262;0.0191)|GBM - Glioblastoma multiforme(486;0.0222)		TCAAGTCCGCGTACTCCTCCG	0.617000													6	130					0	0	1	0	0
ERCC6L	54821	broad.mit.edu	37	X	71427661	71427661	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chrX:71427661G>T	ENST00000373657.1	-	3	1189	c.587C>A	c.(586-588)gCa>gAa	p.A196E	PIN4_ENST00000423432.2_Intron|ERCC6L_ENST00000334463.3_Missense_Mutation_p.A319E			Q2NKX8	ERC6L_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	319	Helicase ATP-binding.				cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol	ATP binding|DNA binding|helicase activity|protein binding			breast(2)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(9)|lung(9)|ovary(3)|skin(1)	38	Renal(35;0.156)					TTTTATGATTGCCATTAAGTT	0.373000													8	134					0.00448238	0.00460003	1	1	0
WDR25	79446	broad.mit.edu	37	14	100992341	100992341	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr14:100992341C>A	ENST00000335290.6	+	5	1462	c.1236C>A	c.(1234-1236)ttC>ttA	p.F412L	WDR25_ENST00000557502.1_3'UTR|WDR25_ENST00000402312.3_Missense_Mutation_p.F412L|WDR25_ENST00000542471.2_Missense_Mutation_p.F155L|WDR25_ENST00000554998.1_Missense_Mutation_p.F412L	NM_024515.4	NP_078791.3	Q64LD2	WDR25_HUMAN	WD repeat domain 25	412										central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(8)|skin(1)	20		Melanoma(154;0.212)				CCTGGGATTTCCGGACCTCTG	0.532000													8	34					0.00448238	0.00460003	1	1	0
ACACB	32	broad.mit.edu	37	12	109617089	109617089	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr12:109617089A>G	ENST00000338432.7	+	10	1753	c.1634A>G	c.(1633-1635)gAg>gGg	p.E545G	ACACB_ENST00000377848.3_Missense_Mutation_p.E545G|ACACB_ENST00000543080.1_3'UTR|ACACB_ENST00000377854.5_Missense_Mutation_p.E545G			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	545	ATP-grasp.|Biotin carboxylation.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	GCCATATTCGAGTTCATGGAG	0.577000													3	13					0	0	1	0	0
CEP350	9857	broad.mit.edu	37	1	179989198	179989198	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:179989198G>C	ENST00000367607.3	+	12	2707	c.2289G>C	c.(2287-2289)ttG>ttC	p.L763F		NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	763						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						CCCATCTCTTGAGTTTAGAGC	0.403000													14	144					0	0	1	0	0
LRRC8B	23507	broad.mit.edu	37	1	90049142	90049142	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:90049142C>G	ENST00000330947.2	+	5	1293	c.933C>G	c.(931-933)atC>atG	p.I311M	RP5-1007M22.2_ENST00000443562.1_RNA|LRRC8B_ENST00000358200.4_Missense_Mutation_p.I311M|LRRC8B_ENST00000439853.1_Missense_Mutation_p.I311M	NM_001134476.1	NP_001127948.1	Q6P9F7	LRC8B_HUMAN	leucine rich repeat containing 8 family, member B	311						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	26		all_lung(203;0.17)		all cancers(265;0.00515)|Epithelial(280;0.0241)		TGGCAGAAATCTTTAAGGTCC	0.418000													10	129					0	0	1	0	0
RARRES1	5918	broad.mit.edu	37	3	158415544	158415544	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:158415544C>T	ENST00000237696.5	-	6	1088	c.808G>A	c.(808-810)Gag>Aag	p.E270K		NM_206963.1	NP_996846.1	P49788	TIG1_HUMAN	retinoic acid receptor responder (tazarotene induced) 1	270					negative regulation of cell proliferation	integral to membrane				NS(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)	9			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)		Tretinoin(DB00755)	GTCTGTAGCTCTTGACAGTGG	0.388000													19	97					0	0	1	0	0
RSL1D1	26156	broad.mit.edu	37	16	11931909	11931909	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr16:11931909C>T	ENST00000571133.1	-	9	1280	c.1208G>A	c.(1207-1209)cGt>cAt	p.R403H	RSL1D1_ENST00000542106.1_Missense_Mutation_p.R183H	NM_015659.2	NP_056474.2	O76021	RL1D1_HUMAN	ribosomal L1 domain containing 1	403					regulation of protein localization|translation	large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			NS(1)|breast(1)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|stomach(2)|urinary_tract(2)	15						tttcttccCACGAGGTGTGCT	0.423000													27	275					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7580126	7580126	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr6:7580126C>G	ENST00000379802.3	+	23	4044	c.3703C>G	c.(3703-3705)Ctt>Gtt	p.L1235V	DSP_ENST00000418664.2_Intron	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1235	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TTCCAAAAATCTTAGAAACCA	0.403000													6	44					0	0	1	0	0
KIF21A	55605	broad.mit.edu	37	12	39751995	39751995	+	Silent	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr12:39751995G>A	ENST00000395670.3	-	8	1619	c.1200C>T	c.(1198-1200)ctC>ctT	p.L400L	KIF21A_ENST00000361961.3_Silent_p.L400L|KIF21A_ENST00000361418.5_Silent_p.L400L|KIF21A_ENST00000541463.2_Silent_p.L400L|KIF21A_ENST00000544797.2_Silent_p.L400L			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	400					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				TGTACTCCATGAGCTCCATCT	0.398000													11	167					0	0	1	0	0
OR6X1	390260	broad.mit.edu	37	11	123624504	123624504	+	Silent	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr11:123624504C>T	ENST00000327930.2	-	1	749	c.723G>A	c.(721-723)tcG>tcA	p.S241S		NM_001005188.1	NP_001005188.1	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X, member 1	241					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)	23		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CTGTCAGGTGCGAGGCACAGG	0.463000													3	53					0	0	1	0	0
ZP2	7783	broad.mit.edu	37	16	21210163	21210163	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr16:21210163C>G	ENST00000574002.1	-	18	2430	c.1948G>C	c.(1948-1950)Gag>Cag	p.E650Q	AF001550.7_ENST00000572747.1_RNA|ZP2_ENST00000219593.4_Missense_Mutation_p.E650Q|ZP2_ENST00000574091.1_Missense_Mutation_p.E641Q			Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 (sperm receptor)	650					binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(16)|ovary(1)|prostate(1)|stomach(1)	41				GBM - Glioblastoma multiforme(48;0.0573)		GTCATTTTCTCTGCTTCAGTG	0.488000													5	38					0	0	1	0	0
ZNF662	389114	broad.mit.edu	37	3	42956704	42956704	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:42956704G>C	ENST00000541208.1	+	5	1508	c.1139G>C	c.(1138-1140)aGa>aCa	p.R380T	KRBOX1_ENST00000426937.1_Intron|ZNF662_ENST00000422021.1_Intron|ZNF662_ENST00000328199.6_Missense_Mutation_p.R406T|ZNF662_ENST00000440367.2_Missense_Mutation_p.R380T			Q6ZS27	ZN662_HUMAN	zinc finger protein 662	380					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R380K(1)		breast(2)|endometrium(1)|large_intestine(6)|lung(5)|upper_aerodigestive_tract(1)	15				KIRC - Kidney renal clear cell carcinoma(284;0.217)		CGACATCAAAGAATCCATACT	0.463000													6	59					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19480387	19480387	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:19480387C>G	ENST00000375267.2	-	45	6508	c.6505G>C	c.(6505-6507)Gag>Cag	p.E2169Q	UBR4_ENST00000375254.3_Missense_Mutation_p.E2169Q|UBR4_ENST00000375226.2_Missense_Mutation_p.E2169Q|UBR4_ENST00000375217.2_Missense_Mutation_p.E2169Q			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	2169					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TTCATCACCTCAGACCACTGG	0.488000													13	67					0	0	1	0	0
ZNF728	388523	broad.mit.edu	37	19	23159728	23159728	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:23159728C>G	ENST00000594710.1	-	4	556	c.411G>C	c.(409-411)ttG>ttC	p.L137F		NM_001267716.1	NP_001254645.1			zinc finger protein 728																		GTGTAGTTGTCAAACTCTGGT	0.313000													4	58					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152085061	152085061	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:152085061C>T	ENST00000368804.1	-	2	631	c.632G>A	c.(631-633)cGa>cAa	p.R211Q		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	211					keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTCCCGCCTTCGCAGTTGCTC	0.567000													20	92					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71795388	71795388	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:71795388G>T	ENST00000258104.3	+	26	3007	c.2730G>T	c.(2728-2730)aaG>aaT	p.K910N	DYSF_ENST00000409366.1_Missense_Mutation_p.K911N|DYSF_ENST00000394120.2_Missense_Mutation_p.K911N|DYSF_ENST00000409651.1_Missense_Mutation_p.K942N|DYSF_ENST00000410020.3_Missense_Mutation_p.K928N|DYSF_ENST00000410041.1_Missense_Mutation_p.K928N|DYSF_ENST00000409582.3_Missense_Mutation_p.K927N|DYSF_ENST00000413539.2_Missense_Mutation_p.K941N|DYSF_ENST00000429174.2_Missense_Mutation_p.K910N|DYSF_ENST00000409744.1_Missense_Mutation_p.K897N|DYSF_ENST00000409762.1_Missense_Mutation_p.K927N	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	910						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						TCACGGGCAAGATCAAGCTAC	0.607000													42	239					3.54909e-21	4.03399e-21	1	1	0
IQGAP1	8826	broad.mit.edu	37	15	91017158	91017158	+	Nonsense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr15:91017158C>T	ENST00000268182.5	+	21	2588	c.2464C>T	c.(2464-2466)Cga>Tga	p.R822*	IQGAP1_ENST00000560738.1_Nonsense_Mutation_p.R250*	NM_003870.3	NP_003861.1	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	822	IQ 3.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			GCACCAAGCTCGAAAGCGCTA	0.488000													4	63					0	0	1	0	0
OR4K5	79317	broad.mit.edu	37	14	20389116	20389116	+	Silent	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr14:20389116G>A	ENST00000315915.4	+	1	376	c.351G>A	c.(349-351)tcG>tcA	p.S117S		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	117					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S117S(1)		central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TACTTGTTTCGATGGCCTATG	0.448000													9	275					0	0	1	0	0
MEX3A	92312	broad.mit.edu	37	1	156046778	156046778	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:156046778C>T	ENST00000532414.2	-	2	1149	c.1150G>A	c.(1150-1152)Gtg>Atg	p.V384M		NM_001093725.1	NP_001087194.1	A1L020	MEX3A_HUMAN	mex-3 RNA binding family member A	384						cytoplasmic mRNA processing body|nucleus	RNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)	9	Hepatocellular(266;0.158)|all_neural(408;0.195)					GTCTCGGCCACGCCGTAGTAC	0.672000													3	20					0	0	1	0	0
ATP13A3	79572	broad.mit.edu	37	3	194165455	194165455	+	Splice_Site	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:194165455G>A	ENST00000439040.1	-	15	2349	c.1558C>T	c.(1558-1560)Cga>Tga	p.R520*	ATP13A3_ENST00000256031.4_Splice_Site_p.R520*			Q9H7F0	AT133_HUMAN	ATPase type 13A3	520					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	24	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		AATATTTACCGTGCATTTTCC	0.318000													37	85					0	0	1	0	0
WDR11	55717	broad.mit.edu	37	10	122626229	122626229	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr10:122626229G>A	ENST00000263461.6	+	8	1389	c.1143G>A	c.(1141-1143)atG>atA	p.M381I		NM_018117.11	NP_060587.8	Q9BZH6	WDR11_HUMAN	WD repeat domain 11	381						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(9)|prostate(2)|skin(2)|stomach(5)	38						GCAGGGTCATGATATGGGAAC	0.443000													5	78					0	0	1	0	0
MCM10	55388	broad.mit.edu	37	10	13213119	13213119	+	Missense_Mutation	SNP	G	G	A	rs146076863	byFrequency	TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr10:13213119G>A	ENST00000378694.1	+	2	280	c.205G>A	c.(205-207)Gac>Aac	p.D69N	MCM10_ENST00000484800.2_Missense_Mutation_p.D69N|MCM10_ENST00000378714.3_Missense_Mutation_p.D69N			Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	69					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			central_nervous_system(1)|large_intestine(4)|ovary(2)|skin(1)|stomach(1)	9						AGAGACAAGAGACGAAAAGGA	0.478000													11	145					0	0	1	0	0
PTGES3L-AARSD1	100885850	broad.mit.edu	37	17	41107954	41107954	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr17:41107954C>G	ENST00000421990.2	-	12	1566	c.1221G>C	c.(1219-1221)aaG>aaC	p.K407N	AARSD1_ENST00000427569.2_Missense_Mutation_p.K233N|PTGES3L-AARSD1_ENST00000409103.1_Missense_Mutation_p.K316N|PTGES3L-AARSD1_ENST00000360221.4_Missense_Mutation_p.K346N|PTGES3L-AARSD1_ENST00000409399.1_Missense_Mutation_p.K407N	NM_001136042.2	NP_001129514.2																					TGGTTCTGTTCTTTTTCCCCT	0.478000													7	128					0	0	1	0	0
ABHD12	26090	broad.mit.edu	37	20	25281503	25281503	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr20:25281503G>A	ENST00000339157.5	-	13	1447	c.1175C>T	c.(1174-1176)tCg>tTg	p.S392L	ABHD12_ENST00000376542.3_Intron	NM_001042472.2	NP_001035937.1	Q8N2K0	ABD12_HUMAN	abhydrolase domain containing 12	392						integral to membrane	acylglycerol lipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(1)|skin(1)|urinary_tract(1)	12						CTCAGGCTCCGACTTCCCCAG	0.557000													3	23					0	0	1	0	0
AP1G2	8906	broad.mit.edu	37	14	24030568	24030568	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr14:24030568C>A	ENST00000308724.5	-	18	2685	c.1930G>T	c.(1930-1932)Gac>Tac	p.D644Y	AP1G2_ENST00000397120.3_Missense_Mutation_p.D644Y|RP11-66N24.3_ENST00000555968.1_RNA	NM_003917.2	NP_003908.1	O75843	AP1G2_HUMAN	adaptor-related protein complex 1, gamma 2 subunit	644					interspecies interaction between organisms|intracellular protein transport|vesicle-mediated transport	AP-1 adaptor complex|endosome membrane	protein binding|protein transporter activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(10)|lung(4)|ovary(1)|pancreas(1)|stomach(1)	28	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00672)		GGGGAGGGGTCCAGATGGGGA	0.597000													5	43					0.000602214	0.000627909	1	1	0
OR4F6	390648	broad.mit.edu	37	15	102346600	102346600	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr15:102346600G>C	ENST00000328882.4	+	1	699	c.678G>C	c.(676-678)caG>caC	p.Q226H		NM_001005326.1	NP_001005326.1	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F, member 6	226					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(1)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			TGACTGTTCAGAAAAAATCTT	0.348000													11	103					0	0	1	0	0
HLA-DPA1	3113	broad.mit.edu	37	6	33036808	33036808	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr6:33036808G>C	ENST00000419277.1	-	4	745	c.616C>G	c.(616-618)Ctc>Gtc	p.L206V	HLA-DPA1_ENST00000428995.1_Missense_Mutation_p.L206V	NM_001242524.1|NM_001242525.1	NP_001229453.1|NP_001229454.1	P20036	DPA1_HUMAN	major histocompatibility complex, class II, DP alpha 1	206	Alpha-2.|Ig-like C1-type.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			kidney(5)|large_intestine(1)|lung(6)|prostate(1)|skin(2)	15						CAGTGCTTGAGGAGCGGCTGG	0.537000													10	95					0	0	1	0	0
PER3	8863	broad.mit.edu	37	1	7845511	7845511	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:7845511G>C	ENST00000377532.3	+	2	363	c.139G>C	c.(139-141)Gat>Cat	p.D47H	PER3_ENST00000377541.1_Missense_Mutation_p.D47H|PER3_ENST00000361923.2_Missense_Mutation_p.D47H			P56645	PER3_HUMAN	period circadian clock 3	47					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			breast(4)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	39	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		TGAACAGCAAGATCGAAACAG	0.408000													3	37					0	0	1	0	0
RANBP6	26953	broad.mit.edu	37	9	6012363	6012363	+	Nonsense_Mutation	SNP	A	A	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr9:6012363A>T	ENST00000259569.5	-	1	3255	c.3245T>A	c.(3244-3246)tTa>tAa	p.L1082*		NM_001243202.1|NM_001243203.1|NM_012416.3	NP_001230131.1|NP_001230132.1|NP_036548.1	O60518	RNBP6_HUMAN	RAN binding protein 6	1082					protein transport	cytoplasm|nucleus	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(5)|large_intestine(8)|lung(9)|ovary(7)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		TTCCAACCATAAATCTTCAGA	0.363000													5	30					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179664232	179664232	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:179664232G>A	ENST00000589042.1	-	6	1120	c.896C>T	c.(895-897)cCg>cTg	p.P299L	TTN_ENST00000342175.6_Missense_Mutation_p.P299L|TTN_ENST00000342992.6_Missense_Mutation_p.P299L|TTN_ENST00000359218.5_Missense_Mutation_p.P299L|TTN_ENST00000460472.2_Missense_Mutation_p.P299L|TTN_ENST00000591111.1_Missense_Mutation_p.P299L|TTN_ENST00000360870.5_Missense_Mutation_p.P299L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	299	ZIS1.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGATGGGGTCGGTGCCCGCAC	0.557000													4	43					0	0	1	0	0
ENPP2	5168	broad.mit.edu	37	8	120606089	120606089	+	Silent	SNP	A	A	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr8:120606089A>G	ENST00000427067.2	-	12	1152	c.972T>C	c.(970-972)ccT>ccC	p.P324P	ENPP2_ENST00000259486.6_Silent_p.P380P|ENPP2_ENST00000075322.6_Silent_p.P328P|ENPP2_ENST00000522826.1_Silent_p.P328P			Q13822	ENPP2_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 2	328					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(30)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)	69	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TTTCCCTCAGAGGATTTGTCA	0.423000													16	191					0	0	1	0	0
VPS35	55737	broad.mit.edu	37	16	46694554	46694554	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr16:46694554G>A	ENST00000299138.7	-	17	2279	c.2221C>T	c.(2221-2223)Cag>Tag	p.Q741*		NM_018206.4	NP_060676.2	Q96QK1	VPS35_HUMAN	vacuolar protein sorting 35 homolog (S. cerevisiae)	741					protein transport|retrograde transport, endosome to Golgi	cytosol|endosome|membrane	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|pancreas(1)|prostate(1)|urinary_tract(1)	23		all_cancers(37;7.65e-05)|all_epithelial(9;0.000154)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TTTAAAACCTGAATTGTTACC	0.338000													6	47					0	0	1	0	0
KIF15	56992	broad.mit.edu	37	3	44854636	44854636	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:44854636G>C	ENST00000326047.4	+	19	2496	c.2347G>C	c.(2347-2349)Gaa>Caa	p.E783Q	KIF15_ENST00000425755.1_Missense_Mutation_p.E418Q	NM_020242.2	NP_064627.1	Q9NS87	KIF15_HUMAN	kinesin family member 15	783					blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		GAATGTCCTTGAAAAGCAGCT	0.343000													6	51					0	0	1	0	0
PPIG	9360	broad.mit.edu	37	2	170493671	170493671	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:170493671G>C	ENST00000260970.3	+	14	2123	c.1903G>C	c.(1903-1905)Gaa>Caa	p.E635Q	PPIG_ENST00000409714.3_Missense_Mutation_p.E620Q|PPIG_ENST00000448752.2_Missense_Mutation_p.E635Q	NM_004792.2	NP_004783.2	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G (cyclophilin G)	635	Arg/Ser-rich (RS domain).				protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(17)|ovary(2)|stomach(1)|urinary_tract(1)	43					L-Proline(DB00172)	AGAGAGAGAAGAAAGTCAAAG	0.428000													3	33					0	0	1	0	0
EPHB3	2049	broad.mit.edu	37	3	184297702	184297702	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:184297702G>A	ENST00000330394.2	+	11	2604	c.2152G>A	c.(2152-2154)Gcc>Acc	p.A718T	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	718	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity	p.A718S(1)		breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			GGAAAACTGCGCCCTGGACTC	0.577000													8	40					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155730356	155730356	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:155730356G>A	ENST00000437809.1	-	24	5110	c.4988C>T	c.(4987-4989)aCc>aTc	p.T1663I	GON4L_ENST00000368331.1_Missense_Mutation_p.T1663I|GON4L_ENST00000271883.5_Missense_Mutation_p.T1663I	NM_001282856.1	NP_001269785.1	Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	1663	PAH 1.				regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					CCGTCTCTGGGTACTTGACTC	0.463000													23	82					0	0	1	0	0
TMEM196	256130	broad.mit.edu	37	7	19765181	19765181	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr7:19765181C>G	ENST00000405844.1	-	3	1110	c.415G>C	c.(415-417)Gaa>Caa	p.E139Q	TMEM196_ENST00000405764.3_Missense_Mutation_p.E139Q|TMEM196_ENST00000422233.1_Missense_Mutation_p.E71Q|TMEM196_ENST00000493519.1_Missense_Mutation_p.E71Q|TMEM196_ENST00000433641.1_Missense_Mutation_p.E71Q			Q5HYL7	TM196_HUMAN	transmembrane protein 196	145						integral to membrane				breast(1)|large_intestine(1)|lung(4)	6						TGCTCCCTTTCTGAGAACATC	0.502000													8	37					0	0	1	0	0
KIAA1324L	222223	broad.mit.edu	37	7	86548557	86548557	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr7:86548557T>C	ENST00000450689.2	-	11	1654	c.1469A>G	c.(1468-1470)aAc>aGc	p.N490S	KIAA1324L_ENST00000297222.6_Missense_Mutation_p.N250S|KIAA1324L_ENST00000416314.1_Missense_Mutation_p.N323S|KIAA1324L_ENST00000444627.1_Missense_Mutation_p.N490S|KIAA1324L_ENST00000490995.1_5'UTR	NM_001142749.2	NP_001136221.1	A8MWY0	K132L_HUMAN	KIAA1324-like	490						integral to membrane				breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(14)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44	Esophageal squamous(14;0.0058)					GATATGCAAGTTTAAGATCAG	0.373000													6	36					0	0	1	0	0
MCM10	55388	broad.mit.edu	37	10	13213179	13213179	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr10:13213179G>C	ENST00000378694.1	+	2	340	c.265G>C	c.(265-267)Gaa>Caa	p.E89Q	MCM10_ENST00000484800.2_Missense_Mutation_p.E89Q|MCM10_ENST00000378714.3_Missense_Mutation_p.E89Q			Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	89					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			central_nervous_system(1)|large_intestine(4)|ovary(2)|skin(1)|stomach(1)	9						AGATGAAGAAGAAGTTCCCGC	0.478000													16	90					0	0	1	0	0
APLNR	187	broad.mit.edu	37	11	57004122	57004122	+	Silent	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr11:57004122G>A	ENST00000606794.1	-	1	553	c.357C>T	c.(355-357)tgC>tgT	p.C119C		NM_005161.4	NP_005152.1	P35414	APJ_HUMAN	apelin receptor	119						integral to plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						GGCCGGTGAGGCAGAAGACGC	0.622000													3	13					0	0	1	0	0
DPEP3	64180	broad.mit.edu	37	16	68010679	68010679	+	Splice_Site	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr16:68010679C>G	ENST00000268793.4	-	8	1467		c.e8-1			NM_001129758.1|NM_022357.3	NP_001123230.1|NP_071752.3	Q9H4B8	DPEP3_HUMAN	dipeptidase 3						meiosis	anchored to membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			breast(4)|endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)	20		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0117)|Epithelial(162;0.0481)|all cancers(182;0.236)		TCAAAGTGATCTAGGGTGGAG	0.572000													3	20					0	0	1	0	0
GJB5	2709	broad.mit.edu	37	1	35223551	35223551	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:35223551A>G	ENST00000338513.1	+	2	793	c.620A>G	c.(619-621)tAc>tGc	p.Y207C		NM_005268.3	NP_005259.1	O95377	CXB5_HUMAN	gap junction protein, beta 5, 31.1kDa	207					cell communication|epidermis development	connexon complex|integral to membrane				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|stomach(1)	10		Myeloproliferative disorder(586;0.0393)				GAGCTCATCTACCTGGTGAGC	0.547000													3	58					0	0	1	0	0
ASPHD2	57168	broad.mit.edu	37	22	26838528	26838528	+	Silent	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr22:26838528G>A	ENST00000215906.5	+	3	1428	c.990G>A	c.(988-990)gcG>gcA	p.A330A		NM_020437.4	NP_065170.2	Q6ICH7	ASPH2_HUMAN	aspartate beta-hydroxylase domain containing 2	330					peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity			endometrium(3)|large_intestine(3)|lung(4)|ovary(1)|prostate(4)|urinary_tract(1)	16						TGCATGCTGCGTTCCATGAAG	0.473000													4	44					0	0	1	0	0
LRRC8C	84230	broad.mit.edu	37	1	90180297	90180297	+	Missense_Mutation	SNP	A	A	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:90180297A>C	ENST00000370454.4	+	3	2423	c.2168A>C	c.(2167-2169)gAt>gCt	p.D723A	LRRC8C_ENST00000479252.1_Intron|RP11-302M6.4_ENST00000370453.5_Intron	NM_032270.4	NP_115646	Q8TDW0	LRC8C_HUMAN	leucine rich repeat containing 8 family, member C	723						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|large_intestine(5)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	28		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)		AGCCTTCCAGATGAACTCTAC	0.353000													13	56					0	0	1	0	0
LRG1	116844	broad.mit.edu	37	19	4538013	4538013	+	Missense_Mutation	SNP	C	C	T	rs148677930	byFrequency	TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:4538013C>T	ENST00000306390.6	-	2	1443	c.983G>A	c.(982-984)cGc>cAc	p.R328H	CTB-50L17.14_ENST00000586020.1_Intron	NM_052972.2	NP_443204.1	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1	328	LRRCT.					extracellular region|membrane				NS(1)|endometrium(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	13		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCAGCACAGCGCGTGTCATT	0.592000													4	35					0	0	1	0	0
ARHGEF19	128272	broad.mit.edu	37	1	16534631	16534631	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:16534631C>G	ENST00000270747.3	-	3	638	c.502G>C	c.(502-504)Gag>Cag	p.E168Q		NM_153213.3	NP_694945.2	Q8IW93	ARHGJ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 19	168					regulation of actin cytoskeleton organization	intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(1)|lung(3)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|Colorectal(212;3.48e-07)|COAD - Colon adenocarcinoma(227;2.19e-05)|BRCA - Breast invasive adenocarcinoma(304;9.46e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0117)|READ - Rectum adenocarcinoma(331;0.0649)		AGGGCCTGCTCTTGCACTACC	0.662000													3	40					0	0	1	0	0
ZSCAN22	342945	broad.mit.edu	37	19	58850342	58850342	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:58850342G>T	ENST00000329665.4	+	3	1273	c.1126G>T	c.(1126-1128)Ggg>Tgg	p.G376W		NM_181846.2	NP_862829.1	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	376					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|pancreas(1)|prostate(2)	16		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		GGTGCACACGGGGGAGCGGCC	0.587000													11	47					1.58986e-06	1.69846e-06	1	1	0
VPS35	55737	broad.mit.edu	37	16	46694559	46694559	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr16:46694559G>T	ENST00000299138.7	-	17	2274	c.2216C>A	c.(2215-2217)aCa>aAa	p.T739K		NM_018206.4	NP_060676.2	Q96QK1	VPS35_HUMAN	vacuolar protein sorting 35 homolog (S. cerevisiae)	739					protein transport|retrograde transport, endosome to Golgi	cytosol|endosome|membrane	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|pancreas(1)|prostate(1)|urinary_tract(1)	23		all_cancers(37;7.65e-05)|all_epithelial(9;0.000154)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				AACCTGAATTGTTACCTACAA	0.343000													6	45					0.00116845	0.00121184	1	1	0
KIAA1407	57577	broad.mit.edu	37	3	113753890	113753890	+	Missense_Mutation	SNP	C	C	T	rs142468996		TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:113753890C>T	ENST00000295878.3	-	6	846	c.700G>A	c.(700-702)Gag>Aag	p.E234K	KIAA1407_ENST00000545063.1_Missense_Mutation_p.E65K	NM_020817.1	NP_065868.1	Q8NCU4	K1407_HUMAN	KIAA1407	234										endometrium(9)|large_intestine(7)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	40						CTTTTCTTCTCTTCTTGCACC	0.473000													12	112					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21628248	21628248	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr7:21628248G>A	ENST00000328843.6	+	11	1998	c.1967G>A	c.(1966-1968)cGt>cAt	p.R656H	DNAH11_ENST00000409508.3_Missense_Mutation_p.R656H			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	656	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						GCATCTCTCCGTTATCTGTAA	0.393000									Kartagener syndrome				7	49					0	0	1	0	0
DIAPH2	1730	broad.mit.edu	37	X	96203943	96203943	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chrX:96203943G>T	ENST00000324765.8	+	15	1866	c.1519G>T	c.(1519-1521)Gaa>Taa	p.E507*	DIAPH2_ENST00000355827.4_Nonsense_Mutation_p.E507*|DIAPH2_ENST00000373061.3_Nonsense_Mutation_p.E507*|DIAPH2_ENST00000373054.4_Nonsense_Mutation_p.E503*|DIAPH2_ENST00000373049.4_Nonsense_Mutation_p.E507*			O60879	DIAP2_HUMAN	diaphanous-related formin 2	507					cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51						GTTCGATGAAGAATTCACAGC	0.353000													4	54					0.150653	0.15104	1	1	0
ZNF709	163051	broad.mit.edu	37	19	12575559	12575559	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:12575559C>T	ENST00000397732.3	-	4	1348	c.1177G>A	c.(1177-1179)Gaa>Aaa	p.E393K	ZNF709_ENST00000428311.1_Missense_Mutation_p.E393K|CTD-3105H18.18_ENST00000598753.1_Intron	NM_152601.3	NP_689814.1	Q8N972	ZN709_HUMAN	zinc finger protein 709	393					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(3)|upper_aerodigestive_tract(3)	6						TGTTTACATTCATAGGGTTTC	0.408000													19	185					0	0	1	0	0
GNL3L	54552	broad.mit.edu	37	X	54574791	54574791	+	Missense_Mutation	SNP	C	C	T	rs145095477		TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chrX:54574791C>T	ENST00000336470.4	+	9	899	c.760C>T	c.(760-762)Cgt>Tgt	p.R254C	GNL3L_ENST00000360845.2_Missense_Mutation_p.R254C	NM_019067.5	NP_061940.1	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3 (nucleolar)-like	254					ribosome biogenesis	nucleolus	GTP binding			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	30						CACCCACATTCGTGTGGGTGT	0.542000													5	30					0	0	1	0	0
SH3BP5	9467	broad.mit.edu	37	3	15301295	15301295	+	Silent	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:15301295G>A	ENST00000383791.3	-	6	862	c.642C>T	c.(640-642)ctC>ctT	p.L214L	SH3BP5_ENST00000253688.5_Silent_p.L57L|SH3BP5-AS1_ENST00000420195.1_RNA|SH3BP5_ENST00000426925.1_Silent_p.L57L|SH3BP5_ENST00000408919.3_Silent_p.L57L	NM_004844.4	NP_004835.2	O60239	3BP5_HUMAN	SH3-domain binding protein 5 (BTK-associated)	214					intracellular signal transduction	mitochondrion	protein kinase inhibitor activity|SH3 domain binding			NS(1)|endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	12						ACTTTGCCTTGAGTTCAAAAT	0.448000													13	102					0	0	1	0	0
FAM179A	165186	broad.mit.edu	37	2	29222194	29222194	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:29222194C>T	ENST00000379558.4	+	4	638	c.287C>T	c.(286-288)gCc>gTc	p.A96V	FAM179A_ENST00000403861.2_Missense_Mutation_p.A96V	NM_199280.2	NP_954974.2	Q6ZUX3	F179A_HUMAN	family with sequence similarity 179, member A	96							binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						AACCTCAGGGCCTTGTCTTTG	0.622000													3	8					0	0	1	0	0
PBRM1	55193	broad.mit.edu	37	3	52621369	52621369	+	Splice_Site	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:52621369C>T	ENST00000356770.4	-	18	3029	c.3027G>A	c.(3025-3027)aaG>aaA	p.K1009K	PBRM1_ENST00000409114.3_Splice_Site_p.K1056K|PBRM1_ENST00000410007.1_Splice_Site_p.K1016K|PBRM1_ENST00000394830.3_Splice_Site_p.K1016K|PBRM1_ENST00000337303.4_Splice_Site_p.K1041K|PBRM1_ENST00000409057.1_Splice_Site_p.K1041K|PBRM1_ENST00000296302.7_Splice_Site_p.K1041K|PBRM1_ENST00000409767.1_Splice_Site_p.K1056K			Q86U86	PB1_HUMAN	polybromo 1	1041	BAH 1.				chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			breast(5)|endometrium(5)|kidney(301)|liver(1)|lung(22)|pancreas(1)	335				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		AGTTTCTTACCTTGACAAACA	0.308000			"""Mis, N, F, S, D, O"""		"""clear cell renal carcinoma, breast"""								6	50					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219875692	219875692	+	Silent	SNP	T	T	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:219875692T>G	ENST00000341552.5	-	25	4067	c.3984A>C	c.(3982-3984)tcA>tcC	p.S1328S	CCDC108_ENST00000453220.1_Silent_p.S1328S|AC097468.4_ENST00000441450.1_RNA|CCDC108_ENST00000441968.1_Silent_p.S1328S	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1328						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCACGGGCACTGAGCCACCAT	0.498000													4	34					0	0	1	0	0
PTOV1	53635	broad.mit.edu	37	19	50360312	50360312	+	Silent	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:50360312C>T	ENST00000391842.1	+	6	809	c.639C>T	c.(637-639)atC>atT	p.I213I	PTOV1_ENST00000601675.1_Silent_p.I213I|PTOV1_ENST00000221557.9_Silent_p.I181I|PTOV1_ENST00000601638.1_Silent_p.I181I|PTOV1_ENST00000598325.1_3'UTR|AC018766.5_ENST00000593654.1_RNA|PTOV1_ENST00000599732.1_Silent_p.I213I|PTOV1_ENST00000600603.1_Silent_p.I181I	NM_017432.3	NP_059128.2	Q86YD1	PTOV1_HUMAN	prostate tumor overexpressed 1	213	Interaction with FLOT1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|plasma membrane				endometrium(5)|kidney(3)|large_intestine(2)|lung(5)|ovary(1)	16		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.0132)		AGAAGAAGATCTTCATGGGCC	0.647000													19	179					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113702259	113702259	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr8:113702259C>T	ENST00000297405.5	-	14	2237	c.1993G>A	c.(1993-1995)Ggt>Agt	p.G665S	CSMD3_ENST00000352409.3_Missense_Mutation_p.G665S|CSMD3_ENST00000343508.3_Missense_Mutation_p.G625S|CSMD3_ENST00000455883.2_Missense_Mutation_p.G561S	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	665	Sushi 3.					integral to membrane|plasma membrane		p.G665R(1)|p.G625R(1)		breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CCAGGATCACCACAACTTTCT	0.363000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			7	110					0	0	1	0	0
EMR2	30817	broad.mit.edu	37	19	14875382	14875382	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:14875382C>T	ENST00000315576.3	-	11	1398	c.947G>A	c.(946-948)gGg>gAg	p.G316E	EMR2_ENST00000392967.2_Missense_Mutation_p.G316E|EMR2_ENST00000353876.1_Missense_Mutation_p.G223E|EMR2_ENST00000392964.3_Missense_Mutation_p.G55E|EMR2_ENST00000594076.1_Missense_Mutation_p.G223E|EMR2_ENST00000594294.1_Missense_Mutation_p.G267E|EMR2_ENST00000353005.1_Missense_Mutation_p.G174E|EMR2_ENST00000346057.1_Missense_Mutation_p.G267E|EMR2_ENST00000392965.3_Missense_Mutation_p.G316E|EMR2_ENST00000595839.1_Missense_Mutation_p.G174E|EMR2_ENST00000601345.1_Missense_Mutation_p.G316E|EMR2_ENST00000596991.2_Missense_Mutation_p.G316E	NM_013447.3	NP_038475.2	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 2	316					cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	48						CTCCAGGTCCCCAGGGGCCTC	0.617000													8	29					0	0	1	0	0
TXNDC2	84203	broad.mit.edu	37	18	9886621	9886621	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr18:9886621C>T	ENST00000306084.6	+	2	344	c.145C>T	c.(145-147)Ctc>Ttc	p.L49F	TXNDC2_ENST00000536353.2_5'UTR|TXNDC2_ENST00000426718.3_3'UTR|TXNDC2_ENST00000357775.5_5'UTR	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	49					cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						CAACGTGCCTCTCCTGGCCCT	0.433000													5	31					0	0	1	0	0
ZAK	51776	broad.mit.edu	37	2	174130948	174130948	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:174130948C>G	ENST00000375213.3	+	20	1951	c.1873C>G	c.(1873-1875)Caa>Gaa	p.Q625E	MLK7-AS1_ENST00000423106.2_RNA|MLK7-AS1_ENST00000422703.1_RNA|MLTK_ENST00000409176.2_Missense_Mutation_p.Q625E	NM_016653.2	NP_057737.2																					CATTAAGTATCAACAGATTAC	0.507000													4	28					0	0	1	0	0
KIAA1549	57670	broad.mit.edu	37	7	138603009	138603009	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr7:138603009C>T	ENST00000440172.1	-	2	1411	c.1363G>A	c.(1363-1365)Gtg>Atg	p.V455M	KIAA1549_ENST00000242365.4_Missense_Mutation_p.V405M|KIAA1549_ENST00000422774.1_Missense_Mutation_p.V455M	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	455						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						TCTTCCAGCACGGTCATGCAC	0.522000			O	BRAF	pilocytic astrocytoma								5	32					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179641888	179641888	+	Missense_Mutation	SNP	T	T	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:179641888T>A	ENST00000589042.1	-	27	5026	c.4802A>T	c.(4801-4803)tAt>tTt	p.Y1601F	TTN_ENST00000342175.6_Missense_Mutation_p.Y1555F|TTN_ENST00000342992.6_Missense_Mutation_p.Y1601F|TTN_ENST00000359218.5_Missense_Mutation_p.Y1555F|TTN_ENST00000460472.2_Missense_Mutation_p.Y1555F|TTN_ENST00000591111.1_Missense_Mutation_p.Y1601F|RP11-88L24.4_ENST00000582038.2_RNA|TTN_ENST00000360870.5_Missense_Mutation_p.Y1601F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1337	Ig-like 7.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATTTTGGGATATTTATGAGG	0.393000													12	88					0	0	1	0	0
MYEOV	26579	broad.mit.edu	37	11	69063240	69063240	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr11:69063240G>C	ENST00000535407.1	+	2	792	c.149G>C	c.(148-150)aGa>aCa	p.R50T	MYEOV_ENST00000308946.3_Missense_Mutation_p.R108T|MYEOV_ENST00000441339.2_Missense_Mutation_p.R108T			Q96EZ4	MYEOV_HUMAN	myeloma overexpressed	108										endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(1)|lung(12)|prostate(2)|skin(1)|urinary_tract(1)	24	all_lung(4;2.21e-19)|Lung NSC(4;6.13e-19)|Melanoma(5;0.00128)		LUSC - Lung squamous cell carcinoma(11;3.33e-11)|STAD - Stomach adenocarcinoma(18;0.00654)|LUAD - Lung adenocarcinoma(13;0.0713)	Kidney(183;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(183;3.23e-08)|Lung(977;0.00361)|LUSC - Lung squamous cell carcinoma(976;0.0153)		GACCGGGAGAGAAACAAGGGA	0.632000													12	1582					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85695995	85695995	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr4:85695995G>A	ENST00000322366.6	-	29	5139	c.4732C>T	c.(4732-4734)Cct>Tct	p.P1578S	WDFY3_ENST00000295888.4_Missense_Mutation_p.P1578S			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	1578						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TTGCTGCTAGGAAAACCTTGC	0.378000													19	50					0	0	1	0	0
BLM	641	broad.mit.edu	37	15	91328217	91328217	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr15:91328217G>C	ENST00000355112.3	+	14	2847	c.2729G>C	c.(2728-2730)aGa>aCa	p.R910T	BLM_ENST00000560136.1_3'UTR|BLM_ENST00000560509.1_Missense_Mutation_p.R910T	NM_000057.2	NP_000048.1	P54132	BLM_HUMAN	Bloom syndrome, RecQ helicase-like	910	Helicase C-terminal.				double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(11)|liver(4)|lung(9)|ovary(6)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			ACGTTACAGAGAGATGGGCTC	0.483000			"""Mis, N, F"""			"""leukemia, lymphoma, skin squamous cell , other cancers"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Bloom syndrome				12	113					0	0	1	0	0
PMFBP1	83449	broad.mit.edu	37	16	72174339	72174339	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr16:72174339C>T	ENST00000537465.1	-	6	937	c.779G>A	c.(778-780)cGa>cAa	p.R260Q	PMFBP1_ENST00000355636.6_Missense_Mutation_p.R115Q|PMFBP1_ENST00000237353.10_Missense_Mutation_p.R260Q			Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	260										NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				CAGCTTATTTCGAAGTTCTTG	0.463000													49	232					0	0	1	0	0
ST8SIA4	7903	broad.mit.edu	37	5	100147715	100147715	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr5:100147715C>G	ENST00000231461.5	-	5	1226	c.916G>C	c.(916-918)Gat>Cat	p.D306H		NM_005668.4	NP_005659.1	Q92187	SIA8D_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	306					axon guidance|N-glycan processing	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)	25		all_cancers(142;1.5e-07)|all_epithelial(76;1.43e-10)|Prostate(80;0.000644)|Lung NSC(167;0.0059)|all_lung(232;0.00914)|Ovarian(225;0.024)|Colorectal(57;0.09)|Breast(839;0.203)		COAD - Colon adenocarcinoma(37;0.00402)		CCATTTAAATCCTTAGGGAAG	0.378000													14	61					0	0	1	0	0
ZSWIM1	90204	broad.mit.edu	37	20	44512080	44512080	+	Silent	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr20:44512080C>T	ENST00000372523.1	+	2	944	c.849C>T	c.(847-849)ttC>ttT	p.F283F	ZSWIM1_ENST00000372520.1_Silent_p.F283F	NM_080603.4	NP_542170.3	Q9BR11	ZSWM1_HUMAN	zinc finger, SWIM-type containing 1	283							zinc ion binding			breast(1)|endometrium(3)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	13		Myeloproliferative disorder(115;0.028)				CTTCTCTGTTCCGTTACATGC	0.542000													8	90					0	0	1	0	0
GALNT14	79623	broad.mit.edu	37	2	31178533	31178533	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:31178533C>T	ENST00000349752.5	-	6	1244	c.605G>A	c.(604-606)tGt>tAt	p.C202Y	GALNT14_ENST00000486564.1_5'UTR|GALNT14_ENST00000356174.3_Missense_Mutation_p.C169Y|GALNT14_ENST00000324589.5_Missense_Mutation_p.C207Y|GALNT14_ENST00000406653.1_Missense_Mutation_p.C182Y|GALNT14_ENST00000420311.2_Missense_Mutation_p.C167Y	NM_024572.3	NP_078848.2	Q96FL9	GLT14_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)	202	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(3)|large_intestine(10)|liver(1)|lung(21)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)	43	Acute lymphoblastic leukemia(172;0.155)					GTTCACCTCACAGTGGCTGTC	0.622000													5	34					0	0	1	0	0
MCM10	55388	broad.mit.edu	37	10	13213117	13213117	+	Missense_Mutation	SNP	G	G	A	rs141967915		TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr10:13213117G>A	ENST00000378694.1	+	2	278	c.203G>A	c.(202-204)aGa>aAa	p.R68K	MCM10_ENST00000484800.2_Missense_Mutation_p.R68K|MCM10_ENST00000378714.3_Missense_Mutation_p.R68K			Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	68					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			central_nervous_system(1)|large_intestine(4)|ovary(2)|skin(1)|stomach(1)	9						GGAGAGACAAGAGACGAAAAG	0.473000													11	148					0	0	1	0	0
PGAM4	441531	broad.mit.edu	37	X	77224501	77224501	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chrX:77224501G>T	ENST00000458128.1	-	1	634	c.635C>A	c.(634-636)aCt>aAt	p.T212N	ATP7A_ENST00000341514.6_Intron|ATP7A_ENST00000343533.5_Intron|ATP7A_ENST00000350425.4_Intron	NM_001029891.2	NP_001025062.1	Q8N0Y7	PGAM4_HUMAN	phosphoglycerate mutase family member 4	212					glycolysis		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity			endometrium(2)|lung(4)	6						GGGAATACCAGTCGGCAGGTT	0.512000													13	164					6.72482e-11	7.49119e-11	1	1	0
PLK1S1	55857	broad.mit.edu	37	20	21209729	21209729	+	RNA	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr20:21209729G>C	ENST00000457464.1	+	0	1356							Q2M2Z5	KIZ_HUMAN	polo-like kinase 1 substrate 1						spindle organization	centrosome	protein kinase binding										TCAAAAGACAGATGCTTCTGT	0.463000													4	30					0	0	1	0	0
KCNA1	3736	broad.mit.edu	37	12	5020587	5020587	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr12:5020587G>A	ENST00000382545.3	+	2	1150	c.43G>A	c.(43-45)Gcc>Acc	p.A15T	KCNA1_ENST00000543874.2_Intron	NM_000217.2	NP_000208.2	Q09470	KCNA1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	15					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity	p.A15P(1)		NS(1)|breast(3)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(23)|ovary(3)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GGCTTCGGCCGCCCCGGGCCA	0.711000													3	28					0	0	1	0	0
VSTM2L	128434	broad.mit.edu	37	20	36560081	36560081	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr20:36560081G>A	ENST00000373461.4	+	2	413	c.166G>A	c.(166-168)Gag>Aag	p.E56K	VSTM2L_ENST00000373459.4_Intron|VSTM2L_ENST00000373458.3_Missense_Mutation_p.E56K	NM_080607.2	NP_542174.1	Q96N03	VTM2L_HUMAN	V-set and transmembrane domain containing 2 like	56	Ig-like.									central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(4)|ovary(1)|skin(1)	8		Myeloproliferative disorder(115;0.00878)				ACGGACGGGCGAGGACGTGGA	0.637000													39	91					0	0	1	0	0
LY9	4063	broad.mit.edu	37	1	160786645	160786645	+	Missense_Mutation	SNP	T	T	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:160786645T>A	ENST00000368037.5	+	5	1448	c.1334T>A	c.(1333-1335)aTc>aAc	p.I445N	LY9_ENST00000263285.6_Missense_Mutation_p.I445N|LY9_ENST00000368041.2_Intron|LY9_ENST00000392203.4_Intron|LY9_ENST00000341032.4_Intron|LY9_ENST00000368040.1_Missense_Mutation_p.I97N	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9		Ig-like C2-type 2.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			TCTGAGAACATCTGTTCAGGT	0.478000													8	49					0	0	1	0	0
OXNAD1	92106	broad.mit.edu	37	3	16345055	16345055	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:16345055G>C	ENST00000285083.5	+	9	1390	c.925G>C	c.(925-927)Gag>Cag	p.E309Q	OXNAD1_ENST00000435829.2_Missense_Mutation_p.E327Q|OXNAD1_ENST00000606098.1_Missense_Mutation_p.E308Q|OXNAD1_ENST00000544043.1_Missense_Mutation_p.E327Q|OXNAD1_ENST00000605932.1_Missense_Mutation_p.E309Q	NM_138381.3	NP_612390.1	Q96HP4	OXND1_HUMAN	oxidoreductase NAD-binding domain containing 1	309							oxidoreductase activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|skin(2)	13						CATTTGCTTTGAGAAGTGGTG	0.403000													4	36					0	0	1	0	0
ALG1L2	644974	broad.mit.edu	37	3	129813257	129813257	+	RNA	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:129813257C>G	ENST00000507643.1	+	0	403							C9J202	AG1L2_HUMAN							biosynthetic process		transferase activity, transferring glycosyl groups										CAAAGGGCCTCTGAGGGAGTA	0.602000													6	41					0	0	1	0	0
TTLL12	23170	broad.mit.edu	37	22	43575866	43575866	+	Silent	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr22:43575866C>G	ENST00000216129.6	-	4	750	c.687G>C	c.(685-687)ctG>ctC	p.L229L		NM_015140.3	NP_055955.1	Q14166	TTL12_HUMAN	tubulin tyrosine ligase-like family, member 12	229					protein modification process		tubulin-tyrosine ligase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)	13		Ovarian(80;0.221)|Glioma(61;0.222)				CCAGGTCCCTCAGGGGCCACA	0.662000													4	22					0	0	1	0	0
ZNF85	7639	broad.mit.edu	37	19	21131734	21131734	+	Silent	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:21131734C>T	ENST00000601023.1	+	2	883	c.237C>T	c.(235-237)ctC>ctT	p.L79L	ZNF85_ENST00000345030.6_Silent_p.L105L|ZNF85_ENST00000328178.8_Silent_p.L138L			Q03923	ZNF85_HUMAN	zinc finger protein 85	138						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)	20						ACCAATGTCTCACAGCTACCC	0.323000													5	98					0	0	1	0	0
ZBTB41	360023	broad.mit.edu	37	1	197169432	197169432	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:197169432G>C	ENST00000367405.4	-	1	240	c.172C>G	c.(172-174)Cca>Gca	p.P58A	ZBTB41_ENST00000467322.1_5'UTR	NM_194314.2	NP_919290.2	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	58					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(11)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	40						CTCTGATCTGGAGAGGGAGGA	0.388000													4	40					0	0	1	0	0
FAM86B1	85002	broad.mit.edu	37	8	12042882	12042882	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr8:12042882C>T	ENST00000321602.8	-	3	445	c.211G>A	c.(211-213)Gaa>Aaa	p.E71K	FAM86B1_ENST00000533852.2_Intron|FAM86B1_ENST00000448228.2_Intron|FAM86B1_ENST00000534520.1_3'UTR			Q8N7N1	F86B1_HUMAN	family with sequence similarity 86, member B1	0										kidney(1)|prostate(1)|stomach(1)	3			STAD - Stomach adenocarcinoma(15;0.033)	COAD - Colon adenocarcinoma(149;0.0965)		CGTGGGGGTTCACCTAGCTCG	0.642000													9	46					0	0	1	0	0
OR4K5	79317	broad.mit.edu	37	14	20389033	20389033	+	Missense_Mutation	SNP	G	G	A	rs151215030		TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr14:20389033G>A	ENST00000315915.4	+	1	293	c.268G>A	c.(268-270)Gag>Aag	p.E90K		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	90					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GAGTGCACACGAGACCATATC	0.428000													39	280					0	0	1	0	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													8	73					0	0	1	0	0
TENC1	23371	broad.mit.edu	37	12	53454336	53454336	+	Missense_Mutation	SNP	A	A	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr12:53454336A>G	ENST00000314250.6	+	19	3055	c.2765A>G	c.(2764-2766)gAa>gGa	p.E922G	TENC1_ENST00000314276.3_Missense_Mutation_p.E932G|TENC1_ENST00000549700.1_Missense_Mutation_p.E857G|TENC1_ENST00000451358.1_Missense_Mutation_p.E912G|TENC1_ENST00000546602.1_Missense_Mutation_p.E825G|TENC1_ENST00000552570.1_Missense_Mutation_p.E922G|TENC1_ENST00000379902.3_Missense_Mutation_p.E798G	NM_170754.2	NP_736610.2	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase (tensin 2)	922	Pro-rich.				intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(19)|ovary(1)|pancreas(1)|stomach(3)	34						CAGGGCAAGGAAAGGTATGCA	0.617000													6	35					0	0	1	0	0
AMER1	139285	broad.mit.edu	37	X	63411958	63411958	+	Silent	SNP	A	A	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chrX:63411958A>G	ENST00000330258.3	-	2	1481	c.1209T>C	c.(1207-1209)gaT>gaC	p.D403D	AMER1_ENST00000403336.1_Silent_p.D403D|AMER1_ENST00000374869.3_Silent_p.D403D	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									CTAAGTCATCAtcttcttcct	0.507000													11	37					0	0	1	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73184366	73184366	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr4:73184366C>G	ENST00000286657.4	-	10	1444	c.1408G>C	c.(1408-1410)Gaa>Caa	p.E470Q		NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	470	Disintegrin.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CCAGGAAGTTCTGGGAGTTTA	0.378000													6	55					0	0	1	0	0
ADNP	23394	broad.mit.edu	37	20	49508334	49508334	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr20:49508334C>G	ENST00000396029.3	-	5	3484	c.2917G>C	c.(2917-2919)Gag>Cag	p.E973Q	ADNP_ENST00000349014.3_Missense_Mutation_p.E973Q|ADNP_ENST00000396032.3_Missense_Mutation_p.E973Q|ADNP_ENST00000371602.4_Missense_Mutation_p.E973Q	NM_001282531.1|NM_015339.2	NP_001269460.1|NP_056154.1	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector homeobox	973						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(7)|kidney(1)|large_intestine(13)|lung(7)|ovary(2)|prostate(2)|skin(2)	39						GGCCCACTCTCAGATGGAGAA	0.478000													10	168					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109617040	109617040	+	Missense_Mutation	SNP	A	A	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr12:109617040A>C	ENST00000338432.7	+	10	1704	c.1585A>C	c.(1585-1587)Aag>Cag	p.K529Q	ACACB_ENST00000377848.3_Missense_Mutation_p.K529Q|ACACB_ENST00000543080.1_3'UTR|ACACB_ENST00000377854.5_Missense_Mutation_p.K529Q			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	529	ATP-grasp.|Biotin carboxylation.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	GCGGCATCAGAAGATCGTTGA	0.592000													5	18					0	0	1	0	0
FRMD5	84978	broad.mit.edu	37	15	44166532	44166532	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr15:44166532C>T	ENST00000417257.1	-	14	1440	c.1264G>A	c.(1264-1266)Gag>Aag	p.E422K	FRMD5_ENST00000484674.1_Missense_Mutation_p.E328K|FRMD5_ENST00000402883.1_Missense_Mutation_p.E422K	NM_032892.3	NP_116281.2	Q7Z6J6	FRMD5_HUMAN	FERM domain containing 5	422						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|cervix(1)|endometrium(2)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	14		all_cancers(109;2.29e-15)|all_epithelial(112;9.98e-13)|Lung NSC(122;4.89e-08)|all_lung(180;5.08e-07)|Melanoma(134;0.0275)		all cancers(107;8.63e-20)|GBM - Glioblastoma multiforme(94;3.63e-06)		CTGTAGGCCTCGTCTGCAATC	0.597000													9	38					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30745886	30745886	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr16:30745886G>A	ENST00000262518.4	+	31	7064	c.6679G>A	c.(6679-6681)Gaa>Aaa	p.E2227K	SRCAP_ENST00000395059.2_Missense_Mutation_p.E2165K|SRCAP_ENST00000344771.4_Missense_Mutation_p.E2069K	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	2227	Glu-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			CTCTGCCCCTGAAGAGGAGGA	0.498000													9	75					0	0	1	0	0
MKNK1	8569	broad.mit.edu	37	1	47028503	47028503	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:47028503C>T	ENST00000371946.4	-	11	944	c.781G>A	c.(781-783)Gaa>Aaa	p.E261K	MKNK1_ENST00000371944.4_Missense_Mutation_p.E125K|MKNK1-AS1_ENST00000602433.1_RNA|MKNK1_ENST00000371945.4_Missense_Mutation_p.E220K|MKNK1_ENST00000428112.2_Missense_Mutation_p.E220K|MKNK1_ENST00000341183.5_Missense_Mutation_p.E220K	NM_003684.5	NP_003675.2	Q9BUB5	MKNK1_HUMAN	MAP kinase interacting serine/threonine kinase 1	261	Protein kinase.				intracellular protein kinase cascade|peptidyl-serine phosphorylation|regulation of translation	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	13	Acute lymphoblastic leukemia(166;0.155)					GCCATGTATTCTGCAGAGCCA	0.592000													5	16					0	0	1	0	0
PI4KA	5297	broad.mit.edu	37	22	21075610	21075610	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr22:21075610C>G	ENST00000255882.6	-	43	5178	c.5092G>C	c.(5092-5094)Gat>Cat	p.D1698H	PI4KA_ENST00000572273.1_Missense_Mutation_p.D1640H|PI4KA_ENST00000414196.3_Missense_Mutation_p.D450H	NM_058004.3	NP_477352.3	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase, catalytic, alpha	1640	Pleckstrin homology (PH) domain conferring phosphoinositide binding specificity (By similarity).				phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(8)|kidney(9)|large_intestine(19)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|salivary_gland(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	79	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			CCCTCTTCATCTAGATAAATG	0.512000													10	37					0	0	1	0	0
MCM10	55388	broad.mit.edu	37	10	13213092	13213092	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr10:13213092G>A	ENST00000378694.1	+	2	253	c.178G>A	c.(178-180)Gat>Aat	p.D60N	MCM10_ENST00000484800.2_Missense_Mutation_p.D60N|MCM10_ENST00000378714.3_Missense_Mutation_p.D60N			Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	60					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			central_nervous_system(1)|large_intestine(4)|ovary(2)|skin(1)|stomach(1)	9						AGAAGAGGCTGATGATGGAGA	0.468000													21	184					0	0	1	0	0
FZD8	8325	broad.mit.edu	37	10	35928822	35928822	+	Silent	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr10:35928822C>T	ENST00000374694.1	-	1	1540	c.1536G>A	c.(1534-1536)tcG>tcA	p.S512S		NM_031866.2	NP_114072.1	Q9H461	FZD8_HUMAN	frizzled family receptor 8	512					axonogenesis|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|T cell differentiation in thymus|vasculature development	cell projection|Golgi apparatus|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	11						GCTTGATGACCGAGCGGATGC	0.642000													5	29					0	0	1	0	0
GOLGB1	2804	broad.mit.edu	37	3	121396153	121396153	+	Silent	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:121396153G>C	ENST00000393667.3	-	16	9128	c.9018C>G	c.(9016-9018)ctC>ctG	p.L3006L	GOLGB1_ENST00000340645.5_Silent_p.L3001L	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	3001					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		ATTGCACTTTGAGAGGCTGAG	0.373000													6	57					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117835997	117835997	+	Missense_Mutation	SNP	T	T	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr9:117835997T>A	ENST00000350763.4	-	10	3510	c.3099A>T	c.(3097-3099)agA>agT	p.R1033S	TNC_ENST00000346706.3_Missense_Mutation_p.R1033S|TNC_ENST00000341037.4_Missense_Mutation_p.R1033S|TNC_ENST00000345230.3_Missense_Mutation_p.R1033S|TNC_ENST00000423613.2_Missense_Mutation_p.R1033S|TNC_ENST00000537320.1_Missense_Mutation_p.R1033S|TNC_ENST00000340094.3_Missense_Mutation_p.R1033S|TNC_ENST00000535648.1_Missense_Mutation_p.R1033S|TNC_ENST00000542877.1_Missense_Mutation_p.R1033S	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	1033	Fibronectin type-III 5.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						AAGTGGTGTTTCTTGGAAGCT	0.572000													7	38					0	0	1	0	0
ACAP1	9744	broad.mit.edu	37	17	7245741	7245741	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr17:7245741C>G	ENST00000158762.3	+	5	498	c.292C>G	c.(292-294)Cta>Gta	p.L98V	ACAP1_ENST00000573893.1_3'UTR	NM_014716.3	NP_055531.1	Q15027	ACAP1_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	98	BAR.|Required for formation of endosomal tubules when overexpressed with PIP5K1C.				intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			NS(1)|breast(5)|cervix(3)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(6)|prostate(3)|skin(1)|urinary_tract(1)	33						TCAGGAGCTTCTAGATGCCAC	0.582000													7	36					0	0	1	0	0
OR4N2	390429	broad.mit.edu	37	14	20295790	20295790	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr14:20295790C>G	ENST00000568211.1	+	1	183	c.183C>G	c.(181-183)ttC>ttG	p.F61L	OR4N2_ENST00000315947.1_Missense_Mutation_p.F61L			Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N, member 2	61					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(32)|ovary(2)|prostate(1)|skin(2)|stomach(2)	52	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CCCTCTATTTCTTTCTGGGCA	0.458000													30	255					0	0	1	0	0
PCDHGA7	56108	broad.mit.edu	37	5	140763839	140763839	+	Nonsense_Mutation	SNP	C	C	G			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr5:140763839C>G	ENST00000518325.1	+	1	1373	c.1373C>G	c.(1372-1374)tCa>tGa	p.S458*	PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron	NM_018920.2	NP_061743.1														NS(1)|biliary_tract(1)|endometrium(8)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|skin(1)|stomach(3)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCATCCTACTCAGTCTACATC	0.517000													5	57					0	0	1	0	0
CAGE1	285782	broad.mit.edu	37	6	7378960	7378960	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr6:7378960G>C	ENST00000502583.1	-	4	1141	c.577C>G	c.(577-579)Cta>Gta	p.L193V	CAGE1_ENST00000296742.7_Missense_Mutation_p.L57V|CAGE1_ENST00000338150.4_Missense_Mutation_p.L193V|CAGE1_ENST00000379918.4_Missense_Mutation_p.L193V|CAGE1_ENST00000509324.1_Intron|CAGE1_ENST00000512086.1_Missense_Mutation_p.L193V	NM_001170692.1	NP_001164163.1	Q8TC20	CAGE1_HUMAN	cancer antigen 1	193										breast(1)|cervix(1)|endometrium(3)|kidney(2)|lung(11)|urinary_tract(1)	19	Ovarian(93;0.0418)					CAGTGGATTAGAGGCGGGCTT	0.438000													9	39					0	0	1	0	0
GMPPB	29925	broad.mit.edu	37	3	49759695	49759695	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr3:49759695G>A	ENST00000480687.1	-	8	853	c.737C>T	c.(736-738)tCa>tTa	p.S246L	GMPPB_ENST00000308375.6_Missense_Mutation_p.S246L|AMIGO3_ENST00000535833.1_5'UTR|GMPPB_ENST00000308388.6_Missense_Mutation_p.S246L			Q9Y5P6	GMPPB_HUMAN	GDP-mannose pyrophosphorylase B	246					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GCCAGGGCCTGAGCACAGCCG	0.582000													8	29					0	0	1	0	0
C11orf57	55216	broad.mit.edu	37	11	111953544	111953544	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr11:111953544G>T	ENST00000532163.1	+	6	1409	c.643G>T	c.(643-645)Gaa>Taa	p.E215*	C11orf57_ENST00000393047.3_Nonsense_Mutation_p.E244*|C11orf57_ENST00000280352.9_Nonsense_Mutation_p.E243*|C11orf57_ENST00000420986.2_Nonsense_Mutation_p.E243*			Q6ZUT1	CK057_HUMAN	chromosome 11 open reading frame 57	243	Lys-rich.									autonomic_ganglia(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)	12		all_cancers(61;9.8e-15)|all_epithelial(67;6.57e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.6e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;7.01e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0521)		GGAAAGTGAGGAAAGAGACAC	0.393000													5	32					1.23904e-05	1.32007e-05	1	1	0
ANO5	203859	broad.mit.edu	37	11	22301269	22301269	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr11:22301269G>C	ENST00000324559.8	+	22	3017	c.2700G>C	c.(2698-2700)atG>atC	p.M900I		NM_001142649.1|NM_213599.2	NP_001136121.1|NP_998764.1	Q75V66	ANO5_HUMAN	anoctamin 5	900						chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(12)|lung(36)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						AGCATGTCATGATTGAGGAAA	0.363000													14	27					0	0	1	0	0
GPD1	2819	broad.mit.edu	37	12	50498482	50498482	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr12:50498482C>T	ENST00000301149.3	+	2	399	c.167C>T	c.(166-168)aCg>aTg	p.T56M	GPD1_ENST00000547190.1_3'UTR|GPD1_ENST00000548814.1_Missense_Mutation_p.T56M	NM_001257199.1|NM_005276.3	NP_001244128.1|NP_005267.2	P21695	GPDA_HUMAN	glycerol-3-phosphate dehydrogenase 1 (soluble)	56					glycerol-3-phosphate catabolic process|triglyceride biosynthetic process	cytosol|glycerol-3-phosphate dehydrogenase complex	glycerol-3-phosphate dehydrogenase|protein homodimerization activity			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	8					NADH(DB00157)	ATCATCAACACGCAGCATGAG	0.552000													9	86					0	0	1	0	0
C1orf87	127795	broad.mit.edu	37	1	60476112	60476112	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:60476112C>A	ENST00000371201.3	-	9	1251	c.1144G>T	c.(1144-1146)Gag>Tag	p.E382*	C1orf87_ENST00000450089.2_Nonsense_Mutation_p.E153*	NM_152377.2	NP_689590.1	Q8N0U7	CA087_HUMAN	chromosome 1 open reading frame 87	382							calcium ion binding			breast(2)|endometrium(2)|large_intestine(6)|lung(19)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33						GTCAGCATCTCAACAAAATTC	0.383000													9	72					0.000442599	0.000465205	1	1	0
CHFR	55743	broad.mit.edu	37	12	133428265	133428265	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr12:133428265G>C	ENST00000266880.7	-	13	1527	c.1464C>G	c.(1462-1464)ttC>ttG	p.F488L	CHFR_ENST00000541837.2_5'UTR|CHFR_ENST00000443047.2_Missense_Mutation_p.F397L|CHFR_ENST00000432561.2_Missense_Mutation_p.F489L|CHFR_ENST00000537522.1_Missense_Mutation_p.F111L|CHFR_ENST00000315585.7_Missense_Mutation_p.F448L|CHFR_ENST00000450056.2_Missense_Mutation_p.F477L			Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase	489					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		GCATGGGCTGGAAGCAGCAGG	0.677000													10	55					0	0	1	0	0
FGD2	221472	broad.mit.edu	37	6	36979561	36979561	+	Missense_Mutation	SNP	A	A	T			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr6:36979561A>T	ENST00000274963.8	+	4	629	c.458A>T	c.(457-459)aAc>aTc	p.N153I		NM_173558.3	NP_775829.2	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	153	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	25						ATCTTCTCCAACATCTCCTCC	0.592000													3	28					0	0	1	0	0
ZNF667	63934	broad.mit.edu	37	19	56969572	56969572	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:56969572C>A	ENST00000591790.1	-	4	1633	c.205G>T	c.(205-207)Ggg>Tgg	p.G69W	ZNF667_ENST00000342634.3_Missense_Mutation_p.G162W|ZNF667_ENST00000292069.6_Missense_Mutation_p.G69W|ZNF667_ENST00000504904.3_Missense_Mutation_p.G69W			Q5HYK9	ZN667_HUMAN	zinc finger protein 667	69	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	38		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		GGTGCTTTCCCTTTCTCCAAT	0.493000													10	65					4.68919e-08	5.10717e-08	1	1	0
C20orf194	25943	broad.mit.edu	37	20	3362093	3362093	+	Silent	SNP	T	T	C			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr20:3362093T>C	ENST00000252032.9	-	3	283	c.216A>G	c.(214-216)ctA>ctG	p.L72L		NM_001009984.2	NP_001009984.1	Q5TEA3	CT194_HUMAN	chromosome 20 open reading frame 194	72										NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	39						ACAAACCAAATAGAAGATAAT	0.408000													8	91					0	0	1	0	0
EGR4	1961	broad.mit.edu	37	2	73518797	73518797	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:73518797G>A	ENST00000436467.2	-	2	1636	c.1249C>T	c.(1249-1251)Cgc>Tgc	p.R417C	EGR4_ENST00000545030.1_Missense_Mutation_p.R520C			B7ZKU3	B7ZKU3_HUMAN	early growth response 4	416						intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						CTGAAGTTGCGGAGGCAGATG	0.667000													6	45					0	0	1	0	0
DHDDS	79947	broad.mit.edu	37	1	26786594	26786594	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr1:26786594G>A	ENST00000360009.2	+	8	801	c.724G>A	c.(724-726)Gag>Aag	p.E242K	DHDDS_ENST00000526219.1_Missense_Mutation_p.E203K|DHDDS_ENST00000236342.7_Missense_Mutation_p.E242K|DHDDS_ENST00000525682.2_Missense_Mutation_p.E208K	NM_024887.3|NM_205861.2	NP_079163.2|NP_995583.1	Q86SQ9	DHDDS_HUMAN	dehydrodolichyl diphosphate synthase	242							protein binding|transferase activity, transferring alkyl or aryl (other than methyl) groups	p.E242K(1)		breast(5)|endometrium(2)|large_intestine(2)|lung(4)|stomach(1)|urinary_tract(1)	15		all_cancers(24;2.04e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.0161)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.166)|LUSC - Lung squamous cell carcinoma(448;0.239)		GAACCTCTTCGAGGCCATCCT	0.493000													15	76					0	0	1	0	0
TNS1	7145	broad.mit.edu	37	2	218712887	218712889	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr2:218712887_218712889delGCT	ENST00000171887.4	-	17	2428_2430	c.1976_1978delAGC	c.(1975-1980)cagcct>cct	p.Q659del	TNS1_ENST00000419504.1_In_Frame_Del_p.Q659del|TNS1_ENST00000430930.1_In_Frame_Del_p.Q659del	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	659	Gln-rich.					cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GGTGGGCGAGgctgctgctgctg	0.660													4	9	---	---	---	---					
POC5	134359	broad.mit.edu	37	5	75003590	75003590	+	Frame_Shift_Del	DEL	A	A	-			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr5:75003590delA	ENST00000428202.2	-	3	384	c.195delT	c.(193-195)tctfs	p.S65fs	POC5_ENST00000504862.1_5'UTR|POC5_ENST00000446329.2_Frame_Shift_Del_p.S40fs|POC5_ENST00000380475.2_5'UTR|POC5_ENST00000510798.1_5'UTR|POC5_ENST00000514838.2_Frame_Shift_Del_p.S65fs	NM_001099271.1	NP_001092741.1	Q8NA72	POC5_HUMAN	POC5 centriolar protein	65					cell cycle	centriole				breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						CATGAATTGTAGAAATTCTGA	0.318													2	4	---	---	---	---					
DLX6	1750	broad.mit.edu	37	7	96635364	96635366	+	In_Frame_Del	DEL	GCA	GCA	-	rs34325324		TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr7:96635364_96635366delGCA	ENST00000518156.2	+	1	505_507	c.75_77delGCA	c.(73-78)gggcag>ggg	p.Q44del	DLX6-AS1_ENST00000430404.2_RNA|DLX6-AS1_ENST00000452769.2_RNA|DLX6-AS1_ENST00000605417.1_RNA|DLX6-AS1_ENST00000458352.2_RNA|DLX6-AS1_ENST00000437541.1_RNA|DLX6-AS1_ENST00000437331.2_RNA|DLX6_ENST00000007660.5_In_Frame_Del_p.Q31del|DLX6-AS1_ENST00000430027.3_RNA			P56179	DLX6_HUMAN	distal-less homeobox 6	0					nervous system development|skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(1)|liver(2)|lung(4)|ovary(2)|urinary_tract(1)	12	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					TGGAGTTCGGgcagcagcagcag	0.640													2	4	---	---	---	---					
WRN	7486	broad.mit.edu	37	8	30998998	30998999	+	Frame_Shift_Ins	INS	-	-	CAAGGAT			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr8:30998998_30998999insCAAGGAT	ENST00000298139.5	+	25	3269_3270	c.3020_3021insCAAGGAT	c.(3019-3024)ggcaagfs	p.-1010fs		NM_000553.4	NP_000544.2	Q14191	WRN_HUMAN	Werner syndrome, RecQ helicase-like						base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(13)|lung(28)|ovary(3)|skin(3)|upper_aerodigestive_tract(3)	60		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		TTTGGCACTGGCAAGGATCAAA	0.376			"""Mis, N, F, S"""			"""osteosarcoma, meningioma, others"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Werner syndrome				8	92	---	---	---	---					
RGS22	26166	broad.mit.edu	37	8	100990176	100990177	+	Frame_Shift_Ins	INS	-	-	G	rs7841915	by1000genomes	TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr8:100990176_100990177insG	ENST00000360863.6	-	23	3681_3682	c.3487_3488insC	c.(3487-3489)ttgfs	p.L1163fs	RGS22_ENST00000523437.1_Frame_Shift_Ins_p.L1151fs|RGS22_ENST00000523287.1_Frame_Shift_Ins_p.L982fs	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	1163					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TAGGACTGCCAATTTTTTTTTC	0.312													8	402	---	---	---	---					
RGS22	26166	broad.mit.edu	37	8	100990178	100990178	+	Frame_Shift_Del	DEL	T	T	-			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr8:100990178delT	ENST00000360863.6	-	23	3680	c.3486delA	c.(3484-3486)aaafs	p.K1162fs	RGS22_ENST00000523437.1_Frame_Shift_Del_p.K1150fs|RGS22_ENST00000523287.1_Frame_Shift_Del_p.K981fs	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	1162					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			GGACTGCCAATTTTTTTTTCT	0.313													8	401	---	---	---	---					
USP2-AS1	100499227	broad.mit.edu	37	11	119274142	119274142	+	RNA	DEL	T	T	-	rs66493459		TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr11:119274142delT	ENST00000498979.2	+	0	273				USP2-AS1_ENST00000500970.1_RNA|USP2-AS1_ENST00000530002.1_RNA|USP2-AS1_ENST00000578923.1_RNA|USP2-AS1_ENST00000577297.1_RNA	NR_034160.1																						AGTGTTTAAGttttttttttt	0.343													2	4	---	---	---	---					
ZNF878	729747	broad.mit.edu	37	19	12167098	12167098	+	Frame_Shift_Del	DEL	C	C	-			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:12167098delC	ENST00000602107.1	-	1	29	c.30delG	c.(28-30)gggfs	p.G10fs				C9JN71	ZN878_HUMAN	zinc finger protein 878	0	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|lung(4)|urinary_tract(1)	8						AAAGGTACAACCCCAGATAGG	0.547													2	4	---	---	---	---					
ZNF45	7596	broad.mit.edu	37	19	44418711	44418711	+	Frame_Shift_Del	DEL	C	C	-			TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr19:44418711delC	ENST00000269973.5	-	10	1967	c.877delG	c.(877-879)gttfs	p.V293fs	ZNF45_ENST00000589703.1_Frame_Shift_Del_p.V293fs|RP11-15A1.2_ENST00000586247.1_RNA	NM_003425.3	NP_003416.1	Q02386	ZNF45_HUMAN	zinc finger protein 45	293					multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	17						TTCAGATGAACTTGAAGATAT	0.458													16	88	---	---	---	---					
RIPK4	54101	broad.mit.edu	37	21	43165934	43165935	+	Frame_Shift_Ins	INS	-	-	G	rs144324321		TCGA-XF-AAMZ-01A-11D-A42E-08	TCGA-XF-AAMZ-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37e1e847-4705-47f1-a991-da03d4841fdb	03166753-067b-4d05-a297-aca7c46ce2ca	g.chr21:43165934_43165935insG	ENST00000352483.2	-	7	1128_1129	c.1064_1065insC	c.(1063-1065)ccgfs	p.P355fs	RIPK4_ENST00000542057.1_Frame_Shift_Ins_p.P244fs|RIPK4_ENST00000332512.3_Frame_Shift_Ins_p.P307fs|RIPK4_ENST00000544709.1_Frame_Shift_Ins_p.P244fs			Q96T11	Q96T11_HUMAN	receptor-interacting serine-threonine kinase 4	307						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						TCCTGGGCTCCGGGGGGCTTTT	0.535													21	80	---	---	---	---					
