Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RIPK4	54101	broad.mit.edu	37	21	43162129	43162129	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr21:43162129C>T	ENST00000352483.2	-	9	1432	c.1368G>A	c.(1366-1368)aaG>aaA	p.K456K	RIPK4_ENST00000544709.1_Silent_p.K345K|RIPK4_ENST00000542057.1_Silent_p.K345K|RIPK4_ENST00000332512.3_Silent_p.K408K			Q96T11	Q96T11_HUMAN	receptor-interacting serine-threonine kinase 4	408						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						CCACAAGCTTCTTCTTCTGGA	0.622000													67	104					0	0	1	0	0
PON1	5444	broad.mit.edu	37	7	94928273	94928273	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr7:94928273G>C	ENST00000222381.3	-	9	1282	c.1051C>G	c.(1051-1053)Ctt>Gtt	p.L351V	PON1_ENST00000542556.1_Missense_Mutation_p.L351V	NM_000446.5	NP_000437.3	P27169	PON1_HUMAN	paraoxonase 1	351					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(6)|lung(11)|pancreas(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	27	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	TCACAGTAAAGAGCTTTGTGA	0.468000													31	63					0	0	1	0	0
MAPK15	225689	broad.mit.edu	37	8	144804378	144804378	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr8:144804378C>A	ENST00000338033.4	+	14	1711	c.1592C>A	c.(1591-1593)tCg>tAg	p.S531*		NM_139021.2	NP_620590.2	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	531					protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|stomach(1)	12	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GTCTGCCACTCGGCACTGGGC	0.677000													7	60					0.000157383	0.000160135	1	1	0
RIPK4	54101	broad.mit.edu	37	21	43161705	43161705	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr21:43161705C>G	ENST00000352483.2	-	9	1856	c.1792G>C	c.(1792-1794)Gag>Cag	p.E598Q	RIPK4_ENST00000544709.1_Missense_Mutation_p.E487Q|RIPK4_ENST00000542057.1_Missense_Mutation_p.E487Q|RIPK4_ENST00000332512.3_Missense_Mutation_p.E550Q			Q96T11	Q96T11_HUMAN	receptor-interacting serine-threonine kinase 4	550						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						ACGATATTCTCCTGCCCGTGC	0.657000													15	21					0	0	1	0	0
DNAL1	83544	broad.mit.edu	37	14	74162637	74162637	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr14:74162637G>C	ENST00000553645.2	+	8	606	c.565G>C	c.(565-567)Gac>Cac	p.D189H	DNAL1_ENST00000540526.1_Missense_Mutation_p.D150H|DNAL1_ENST00000554339.1_Missense_Mutation_p.D102H|DNAL1_ENST00000311089.3_Missense_Mutation_p.D76H|DNAL1_ENST00000554871.1_Missense_Mutation_p.D150H	NM_031427.3	NP_113615.2	Q4LDG9	DNAL1_HUMAN	dynein, axonemal, light chain 1		LRRCT.									kidney(1)|lung(2)	3				BRCA - Breast invasive adenocarcinoma(234;0.00384)|KIRC - Kidney renal clear cell carcinoma(182;0.095)		TGAGGAAGAAGACAACTAATG	0.264000													4	6					0	0	1	0	0
SLC25A13	10165	broad.mit.edu	37	7	95906580	95906580	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr7:95906580A>T	ENST00000416240.2	-	3	330	c.140T>A	c.(139-141)aTt>aAt	p.I47N	SLC25A13_ENST00000542654.1_5'UTR|SLC25A13_ENST00000265631.5_Missense_Mutation_p.I47N	NM_001160210.1|NM_014251.2	NP_001153682.1|NP_055066.1	Q9UJS0	CMC2_HUMAN	solute carrier family 25 (aspartate/glutamate carrier), member 13	47					ATP biosynthetic process|gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to plasma membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity			breast(4)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|prostate(1)|skin(4)	42	all_cancers(62;7.75e-08)|all_epithelial(64;1.16e-07)		STAD - Stomach adenocarcinoma(171;0.194)		L-Aspartic Acid(DB00128)	TTCTCCAAAAATGTTCAAGTA	0.328000													11	36					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51184034	51184034	+	Silent	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr3:51184034G>A	ENST00000266037.9	+	10	824	c.801G>A	c.(799-801)aaG>aaA	p.K267K		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	267						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		ACCCAGAGAAGATAGAACGAA	0.428000													3	4					0	0	1	0	0
CDK8	1024	broad.mit.edu	37	13	26970427	26970427	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr13:26970427G>C	ENST00000381527.3	+	8	1299	c.796G>C	c.(796-798)Gat>Cat	p.D266H	CDK8_ENST00000536792.1_3'UTR	NM_001260.1	NP_001251.1	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	266	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	25	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		CACAGATAAAGATTGGGAAGA	0.284000													11	18					0	0	1	0	0
MFRP	83552	broad.mit.edu	37	11	119215584	119215584	+	Splice_Site	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr11:119215584C>T	ENST00000555262.1	-	6	931	c.772G>A	c.(772-774)Ggg>Agg	p.G258R	MFRP_ENST00000530681.1_Splice_Site_p.G258R|MFRP_ENST00000360167.4_Splice_Site_p.G258R|C1QTNF5_ENST00000445041.2_5'UTR|MFRP_ENST00000449574.2_Splice_Site_p.G258R	NM_001278431.1	NP_001265360.1			membrane frizzled-related protein											autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)|urinary_tract(1)	18		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		ACACACTCACCGCGCCCAGGG	0.602000													6	7					0	0	1	0	0
C4BPA	722	broad.mit.edu	37	1	207297548	207297548	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:207297548C>T	ENST00000367070.3	+	6	737	c.543C>T	c.(541-543)atC>atT	p.I181I		NM_000715.3	NP_000706.1	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	181	Sushi 3.				complement activation, classical pathway|innate immune response	extracellular region	protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)|skin(1)|urinary_tract(2)	28						CTCCAGACATCAGGAATGGAA	0.458000													22	136					0	0	1	0	0
RHOB	388	broad.mit.edu	37	2	20647495	20647495	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr2:20647495A>G	ENST00000272233.4	+	1	661	c.269A>G	c.(268-270)gAc>gGc	p.D90G		NM_004040.2	NP_004031.1	P62745	RHOB_HUMAN	ras homolog family member B	90					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			breast(1)|kidney(1)|lung(2)|ovary(1)|urinary_tract(2)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		GACAGCCCGGACTCGCTGGAG	0.627000													101	56					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11187752	11187752	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:11187752C>T	ENST00000361445.4	-	44	6221	c.6145G>A	c.(6145-6147)Gag>Aag	p.E2049K	MTOR_ENST00000376838.1_Missense_Mutation_p.E254K	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	2049					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						TCCAGCACCTCAAACATGCCT	0.507000													53	172					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90368421	90368421	+	Splice_Site	SNP	G	G	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr5:90368421G>T	ENST00000405460.2	+	86	18406	c.18310G>T	c.(18310-18312)Gaa>Taa	p.E6104*	GPR98_ENST00000425867.2_Splice_Site_p.E1765*	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	6104					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AAATGCTGCAGGTTTGAAAGG	0.433000													47	30					1.05386e-31	1.1443e-31	1	1	0
APOL6	80830	broad.mit.edu	37	22	36054951	36054951	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr22:36054951C>T	ENST00000409652.4	+	3	616	c.340C>T	c.(340-342)Caa>Taa	p.Q114*		NM_030641.3	NP_085144.1	Q9BWW8	APOL6_HUMAN	apolipoprotein L, 6						lipoprotein metabolic process	cytoplasm|extracellular region	lipid binding|lipid transporter activity			haematopoietic_and_lymphoid_tissue(1)|lung(4)	5						CACCGCTGGTCAAGGTTTGGC	0.577000													6	40					0	0	1	0	0
ZCCHC7	84186	broad.mit.edu	37	9	37126451	37126451	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr9:37126451A>G	ENST00000336755.5	+	2	228	c.122A>G	c.(121-123)tAt>tGt	p.Y41C	ZCCHC7_ENST00000461038.1_3'UTR|ZCCHC7_ENST00000322831.6_Missense_Mutation_p.Y40C|ZCCHC7_ENST00000534928.1_Intron	NM_032226.2	NP_115602.2	Q8N3Z6	ZCHC7_HUMAN	zinc finger, CCHC domain containing 7	41							nucleic acid binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	30				GBM - Glioblastoma multiforme(29;0.0137)		CAAATTCATTATGCCCAAGAT	0.388000													12	110					0	0	1	0	0
SLC41A3	54946	broad.mit.edu	37	3	125727640	125727640	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr3:125727640C>G	ENST00000383598.2	-	9	1396	c.1111G>C	c.(1111-1113)Gag>Cag	p.E371Q	SLC41A3_ENST00000508835.1_Missense_Mutation_p.E280Q|SLC41A3_ENST00000346785.5_Missense_Mutation_p.E361Q|SLC41A3_ENST00000315891.6_Missense_Mutation_p.E397Q|SLC41A3_ENST00000360370.4_Missense_Mutation_p.E397Q	NM_001008487.1	NP_001008487.1	Q96GZ6	S41A3_HUMAN	solute carrier family 41, member 3	397						integral to membrane|plasma membrane	cation transmembrane transporter activity			breast(1)|endometrium(4)|large_intestine(6)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18				GBM - Glioblastoma multiforme(114;0.167)		GACTGACCCTCCACCAGGTAG	0.517000													12	70					0	0	1	0	0
PHLDA3	23612	broad.mit.edu	37	1	201437606	201437606	+	Silent	SNP	G	G	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:201437606G>T	ENST00000367311.3	-	1	706	c.309C>A	c.(307-309)gtC>gtA	p.V103V	PHLDA3_ENST00000367309.1_Silent_p.V103V|PHLDA3_ENST00000485436.1_5'UTR	NM_012396.3	NP_036528.1	Q9Y5J5	PHLA3_HUMAN	pleckstrin homology-like domain, family A, member 3	103	PH.				anatomical structure morphogenesis|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of protein kinase B signaling cascade	cytoplasm|intracellular membrane-bounded organelle|plasma membrane	identical protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding			lung(1)|prostate(1)	2						TCTTGAACTTGACCAGGCCTA	0.637000													39	80					8.69298e-16	9.30021e-16	1	1	0
AAR2	25980	broad.mit.edu	37	20	34832712	34832712	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr20:34832712C>T	ENST00000373932.3	+	3	1197	c.851C>T	c.(850-852)tCa>tTa	p.S284L	AAR2_ENST00000397286.3_Missense_Mutation_p.S284L|AAR2_ENST00000320849.4_Missense_Mutation_p.S284L	NM_015511.3	NP_056326.2			AAR2 splicing factor homolog (S. cerevisiae)																		CTGTGCCGGTCAGAAGCAGCC	0.522000													9	53					0	0	1	0	0
ARL2-SNX15	100528018	broad.mit.edu	37	11	64781732	64781732	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr11:64781732G>T	ENST00000301886.3	+	1	79	c.53G>T	c.(52-54)cGa>cTa	p.R18L	ARL2_ENST00000246747.4_Missense_Mutation_p.R18L|ARL2_ENST00000529384.1_Missense_Mutation_p.R18L|ARL2_ENST00000533729.1_Missense_Mutation_p.R18L																							CGGGAGCTGCGACTGCTCATG	0.701000													5	2					0.184627	0.184627	1	1	0
ACVR1B	91	broad.mit.edu	37	12	52380627	52380627	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr12:52380627G>A	ENST00000257963.4	+	7	1239	c.1162G>A	c.(1162-1164)Gaa>Aaa	p.E388K	ACVR1B_ENST00000415850.2_Missense_Mutation_p.E388K|ACVR1B_ENST00000563121.1_Intron|ACVR1B_ENST00000426655.2_Missense_Mutation_p.E388K|ACVR1B_ENST00000541224.1_Missense_Mutation_p.E429K|ACVR1B_ENST00000542485.1_Missense_Mutation_p.E336K	NM_004302.4|NM_020328.3	NP_004293.1|NP_064733.3	P36896	ACV1B_HUMAN	activin A receptor, type IB	388	Protein kinase.				G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|peptidyl-threonine phosphorylation|positive regulation of activin receptor signaling pathway|positive regulation of erythrocyte differentiation|protein autophosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway	cell surface	activin receptor activity, type I|ATP binding|metal ion binding|SMAD binding|transforming growth factor beta receptor activity|ubiquitin protein ligase binding	p.D387fs*3(2)		breast(5)|endometrium(4)|kidney(5)|large_intestine(12)|lung(10)|ovary(1)|pancreas(6)|prostate(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.104)	Adenosine triphosphate(DB00171)	AGTACTTGATGAAACCATTAA	0.393000													29	100					0	0	1	0	0
TLN1	7094	broad.mit.edu	37	9	35710623	35710623	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr9:35710623C>T	ENST00000314888.9	-	33	4614	c.4261G>A	c.(4261-4263)Gag>Aag	p.E1421K	TLN1_ENST00000540444.1_Missense_Mutation_p.E1421K	NM_006289.3	NP_006280.3	Q9Y490	TLN1_HUMAN	talin 1	1421	Interaction with SYNM.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			NS(2)|breast(8)|central_nervous_system(2)|endometrium(10)|kidney(5)|large_intestine(9)|lung(32)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(6)	85	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TCTCCAAACTCTGGCAGGTTT	0.542000													3	29					0	0	1	0	0
DPP8	54878	broad.mit.edu	37	15	65756239	65756239	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr15:65756239G>C	ENST00000341861.5	-	15	3459	c.1879C>G	c.(1879-1881)Ctt>Gtt	p.L627V	DPP8_ENST00000321118.7_Missense_Mutation_p.L627V|DPP8_ENST00000339244.5_Missense_Mutation_p.L454V|DPP8_ENST00000559233.1_Missense_Mutation_p.L627V|DPP8_ENST00000321147.6_Missense_Mutation_p.L627V|DPP8_ENST00000358939.4_Missense_Mutation_p.L611V|DPP8_ENST00000300141.6_Missense_Mutation_p.L611V	NM_197960.2	NP_932064.1	Q6V1X1	DPP8_HUMAN	dipeptidyl-peptidase 8	627					immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			NS(1)|breast(2)|endometrium(3)|large_intestine(11)|lung(11)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						TAGTCAGGAAGAGGACCTGTG	0.403000													14	39					0	0	1	0	0
KDM6A	7403	broad.mit.edu	37	X	44929017	44929017	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chrX:44929017C>G	ENST00000377967.4	+	17	2158	c.2117C>G	c.(2116-2118)tCa>tGa	p.S706*	KDM6A_ENST00000543216.1_Nonsense_Mutation_p.S627*|KDM6A_ENST00000536777.1_Nonsense_Mutation_p.S661*|KDM6A_ENST00000382899.4_Nonsense_Mutation_p.S713*	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	706					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)|p.T705fs*7(1)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						ACTGCTACCTCAGGTGGACAA	0.507000			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								6	8					0	0	1	0	0
PADI2	11240	broad.mit.edu	37	1	17431417	17431417	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:17431417G>A	ENST00000375486.4	-	2	295	c.232C>T	c.(232-234)Cgg>Tgg	p.R78W	PADI2_ENST00000375481.1_Missense_Mutation_p.R78W|PADI2_ENST00000444885.2_Missense_Mutation_p.R78W	NM_007365.2	NP_031391.2	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	78					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(12)|ovary(4)|pancreas(1)|skin(5)|urinary_tract(3)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	ATGGTGACCCGCAGGGTGGTG	0.672000													12	28					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	118949582	118949582	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr9:118949582C>T	ENST00000328252.3	+	2	934	c.565C>T	c.(565-567)Cgc>Tgc	p.R189C		NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	189					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						CAATGCCCACCGCAGCTACCT	0.557000													23	17					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8139986	8139986	+	Silent	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr19:8139986G>A	ENST00000600128.1	-	61	8085	c.7671C>T	c.(7669-7671)ttC>ttT	p.F2557F	FBN3_ENST00000270509.2_Silent_p.F2557F|FBN3_ENST00000601739.1_Silent_p.F2557F			Q75N90	FBN3_HUMAN	fibrillin 3	2557	EGF-like 42; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						AGTGCTGGGTGAAACCCTGGG	0.597000													17	38					0	0	1	0	0
CADPS	8618	broad.mit.edu	37	3	62860618	62860618	+	Silent	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr3:62860618G>A	ENST00000383710.4	-	1	436	c.87C>T	c.(85-87)tcC>tcT	p.S29S	CADPS_ENST00000283269.9_Silent_p.S29S|CADPS_ENST00000490353.2_Silent_p.S29S|CADPS_ENST00000357948.3_Silent_p.S29S	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	29					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		GGCGCGCGCCGGACGGGGCCG	0.751000													5	6					0	0	1	0	0
SMG7	9887	broad.mit.edu	37	1	183521065	183521065	+	Silent	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:183521065G>A	ENST00000367537.3	+	24	3707	c.3512G>A	c.(3511-3513)tGa>tAa	p.*1171*	SMG7_ENST00000347615.2_Silent_p.*1138*|SMG7_ENST00000508461.1_Silent_p.*1146*|SMG7_ENST00000515829.2_Silent_p.*1092*|SMG7_ENST00000456731.2_Silent_p.*1050*|SMG7_ENST00000507469.1_Intron			Q92540	SMG7_HUMAN	SMG7 nonsense mediated mRNA decay factor	0					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(16)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	46						CCTCCACACTGAGGCCAAAGT	0.552000													16	19					0	0	1	0	0
LHX2	9355	broad.mit.edu	37	9	126794805	126794805	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr9:126794805C>G	ENST00000373615.4	+	5	1779	c.1040C>G	c.(1039-1041)tCg>tGg	p.S347W		NM_004789.3	NP_004780.3	P50458	LHX2_HUMAN	LIM homeobox 2	347						nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)	10						GGGACGCCATCGGGCCCGGCC	0.657000													21	13					0	0	1	0	0
SERPINA12	145264	broad.mit.edu	37	14	94964210	94964210	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr14:94964210C>T	ENST00000341228.2	-	3	1320	c.525G>A	c.(523-525)aaG>aaA	p.K175K	SERPINA12_ENST00000556881.1_Silent_p.K175K	NM_173850.2	NP_776249.1	Q8IW75	SPA12_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12	175					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33				COAD - Colon adenocarcinoma(157;0.235)		CATTGATCTGCTTCTGAGCCA	0.408000													46	78					0	0	1	0	0
TNIK	23043	broad.mit.edu	37	3	170843742	170843742	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr3:170843742G>A	ENST00000436636.2	-	17	2316	c.1972C>T	c.(1972-1974)Cga>Tga	p.R658*	TNIK_ENST00000538048.1_Nonsense_Mutation_p.R603*|TNIK_ENST00000470834.1_Nonsense_Mutation_p.R629*|TNIK_ENST00000369326.5_Nonsense_Mutation_p.R629*|TNIK_ENST00000341852.6_Nonsense_Mutation_p.R574*|TNIK_ENST00000357327.5_Nonsense_Mutation_p.R629*|TNIK_ENST00000488470.1_Nonsense_Mutation_p.R603*|TNIK_ENST00000460047.1_Nonsense_Mutation_p.R603*|TNIK_ENST00000284483.8_Nonsense_Mutation_p.R658*|TNIK_ENST00000475336.1_Nonsense_Mutation_p.R574*	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	658	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			CAAGAGCTTCGGTCAAACTTT	0.473000													9	35					0	0	1	0	0
TM9SF4	9777	broad.mit.edu	37	20	30730854	30730854	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr20:30730854C>T	ENST00000217315.5	+	6	887	c.547C>T	c.(547-549)Cac>Tac	p.H183Y	TM9SF4_ENST00000398022.2_Missense_Mutation_p.H200Y			Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	200						integral to membrane				central_nervous_system(2)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GGACCAGGAGCACACGTACCG	0.577000													15	53					0	0	1	0	0
TRIM37	4591	broad.mit.edu	37	17	57109287	57109287	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr17:57109287G>A	ENST00000376149.3	-	18	2361	c.1552C>T	c.(1552-1554)Cgc>Tgc	p.R518C	TRIM37_ENST00000262294.7_Missense_Mutation_p.R640C|TRIM37_ENST00000393065.2_Missense_Mutation_p.R606C|TRIM37_ENST00000393066.3_Missense_Mutation_p.R640C			O94972	TRI37_HUMAN	tripartite motif containing 37	640						perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(13)|ovary(1)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					GCAGGTGGGCGAGGCTGTAAG	0.373000									Mulibrey Nanism				32	74					0	0	1	0	0
BLMH	642	broad.mit.edu	37	17	28576040	28576040	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr17:28576040C>G	ENST00000261714.6	-	12	1537	c.1363G>C	c.(1363-1365)Gag>Cag	p.E455Q	RP11-354P11.2_ENST00000577420.1_RNA|BLMH_ENST00000394819.3_Missense_Mutation_p.E368Q	NM_000386.3	NP_000377.1	Q13867	BLMH_HUMAN	bleomycin hydrolase	455					proteolysis	cytoplasm|nucleus	aminopeptidase activity|carboxypeptidase activity|cysteine-type endopeptidase activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(1)|prostate(1)|stomach(1)	13						CAGTATCACTCAGCCAAAGCT	0.542000													6	32					0	0	1	0	0
SLC5A11	115584	broad.mit.edu	37	16	24921659	24921659	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr16:24921659C>A	ENST00000347898.3	+	15	2305	c.1683C>A	c.(1681-1683)gaC>gaA	p.D561E	SLC5A11_ENST00000449109.2_Missense_Mutation_p.D405E|SLC5A11_ENST00000568579.1_Missense_Mutation_p.D491E|SLC5A11_ENST00000565769.1_Missense_Mutation_p.D497E|SLC5A11_ENST00000545376.1_Missense_Mutation_p.D491E|SLC5A11_ENST00000567758.1_Missense_Mutation_p.D526E|SLC5A11_ENST00000539472.1_Missense_Mutation_p.D497E|SLC5A11_ENST00000569071.1_Missense_Mutation_p.D405E|SLC5A11_ENST00000424767.2_Missense_Mutation_p.D526E	NM_052944.3	NP_443176.2	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/inositol cotransporter), member 11	561					apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(30)|ovary(2)|prostate(2)|urinary_tract(1)	49				GBM - Glioblastoma multiforme(48;0.0365)		CTCGTCACGACCCCGTGGTCC	0.577000													18	60					8.10497e-08	8.51461e-08	1	1	0
PYGM	5837	broad.mit.edu	37	11	64514234	64514234	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr11:64514234G>A	ENST00000164139.3	-	20	2824	c.2426C>T	c.(2425-2427)tCt>tTt	p.S809F	PYGM_ENST00000377432.3_Missense_Mutation_p.S721F	NM_005609.2	NP_005600.1	P11217	PYGM_HUMAN	phosphorylase, glycogen, muscle	809					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					Pyridoxal Phosphate(DB00114)	GAACTTGCCAGAGGTGGCTAT	0.612000													34	17					0	0	1	0	0
SH3BP2	6452	broad.mit.edu	37	4	2829042	2829042	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr4:2829042G>T	ENST00000356331.5	+	6	775	c.514G>T	c.(514-516)Gaa>Taa	p.E172*	SH3BP2_ENST00000452765.2_Nonsense_Mutation_p.E172*|SH3BP2_ENST00000515183.1_3'UTR|SH3BP2_ENST00000503393.2_Nonsense_Mutation_p.E229*|SH3BP2_ENST00000442312.2_Nonsense_Mutation_p.E200*|SH3BP2_ENST00000511747.1_Nonsense_Mutation_p.E172*|SH3BP2_ENST00000435136.2_Nonsense_Mutation_p.E172*	NM_003023.4	NP_003014.3	P78314	3BP2_HUMAN	SH3-domain binding protein 2	172					signal transduction		SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	20				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		CACGGACAATGAAGGTGAGGT	0.617000									Cherubism				10	42					2.17888e-05	2.25642e-05	1	1	0
PRDM13	59336	broad.mit.edu	37	6	100062341	100062341	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr6:100062341C>T	ENST00000369215.4	+	4	2135	c.1830C>T	c.(1828-1830)ttC>ttT	p.F610F		NM_021620.3	NP_067633.2	Q9H4Q3	PRD13_HUMAN	PR domain containing 13	610					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.F610L(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(9)|prostate(1)	17		all_cancers(76;1.64e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0128)|Colorectal(196;0.069)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0598)		TGCGGCCCTTCGGCGACCCCA	0.617000													20	12					0	0	1	0	0
TUBB3	10381	broad.mit.edu	37	16	90002146	90002146	+	Silent	SNP	G	G	A	rs142238093	byFrequency	TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr16:90002146G>A	ENST00000304984.5	+	3	3366	c.1071G>A	c.(1069-1071)acG>acA	p.T357T	TUBB3_ENST00000556922.1_Silent_p.T776T|TUBB3_ENST00000315491.7_Silent_p.T429T|TUBB3_ENST00000554444.1_Silent_p.T357T|TUBB3_ENST00000555576.1_Intron			Q13509	TBB3_HUMAN	tubulin, beta 3 class III	429					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(3)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	17		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		AGGACGCCACGGCCGAGGAAG	0.637000													34	77					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186544663	186544663	+	Silent	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr4:186544663G>A	ENST00000431808.1	-	14	2471	c.1908C>T	c.(1906-1908)taC>taT	p.Y636Y	SORBS2_ENST00000418609.1_Silent_p.Y540Y|SORBS2_ENST00000393528.3_Intron|SORBS2_ENST00000449407.2_Intron|SORBS2_ENST00000284776.7_Silent_p.Y636Y|SORBS2_ENST00000355634.5_Silent_p.Y736Y|SORBS2_ENST00000319471.9_Intron|SORBS2_ENST00000437304.2_Intron|SORBS2_ENST00000448662.2_Intron|SORBS2_ENST00000498125.1_Intron			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	636						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		ggCTGGATCCGTAAAAGCTTT	0.537000													3	30					0	0	1	0	0
GCM2	9247	broad.mit.edu	37	6	10874964	10874964	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr6:10874964G>C	ENST00000379491.4	-	5	932	c.785C>G	c.(784-786)tCa>tGa	p.S262*	SYCP2L_ENST00000543878.1_Intron|RP11-637O19.3_ENST00000480294.1_Intron	NM_004752.3	NP_004743.1	O75603	GCM2_HUMAN	glial cells missing homolog 2 (Drosophila)	262					cellular calcium ion homeostasis|cellular phosphate ion homeostasis|parathyroid gland development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	30	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)				TCTTGGGCTTGAGTATTTCTG	0.468000													54	34					0	0	1	0	0
ZNF782	158431	broad.mit.edu	37	9	99581910	99581910	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr9:99581910C>G	ENST00000481138.1	-	6	1056	c.395G>C	c.(394-396)aGa>aCa	p.R132T	ZNF782_ENST00000466833.1_5'UTR|ZNF782_ENST00000535338.1_5'UTR	NM_001001662.1	NP_001001662.1	Q6ZMW2	ZN782_HUMAN	zinc finger protein 782	132					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(8)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)	33		Acute lymphoblastic leukemia(62;0.0527)				AGGCATCATTCTTGCACGAAA	0.408000													31	19					0	0	1	0	0
C1orf43	25912	broad.mit.edu	37	1	154184824	154184824	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:154184824G>C	ENST00000368521.5	-	6	736	c.538C>G	c.(538-540)Cag>Gag	p.Q180E	C1orf43_ENST00000362076.4_Missense_Mutation_p.Q128E|C1orf43_ENST00000368516.1_Missense_Mutation_p.Q146E|C1orf43_ENST00000368519.1_Missense_Mutation_p.Q162E|C1orf43_ENST00000350592.3_Missense_Mutation_p.Q146E|C1orf43_ENST00000368518.1_Missense_Mutation_p.Q180E	NM_001098616.1	NP_001092086.1	Q9BWL3	CA043_HUMAN	chromosome 1 open reading frame 43	180						integral to membrane	coenzyme binding|oxidoreductase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)	10	all_lung(78;1.98e-30)|Lung NSC(65;2.87e-28)|Hepatocellular(266;0.0877)					AGGGCCTCCTGATAGCGTAGG	0.522000													4	144					0	0	1	0	0
BLMH	642	broad.mit.edu	37	17	28576036	28576036	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr17:28576036C>T	ENST00000261714.6	-	12	1541	c.1367G>A	c.(1366-1368)tGa>tAa	p.*456*	RP11-354P11.2_ENST00000577420.1_RNA|BLMH_ENST00000394819.3_Silent_p.*369*	NM_000386.3	NP_000377.1	Q13867	BLMH_HUMAN	bleomycin hydrolase	0					proteolysis	cytoplasm|nucleus	aminopeptidase activity|carboxypeptidase activity|cysteine-type endopeptidase activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(1)|prostate(1)|stomach(1)	13						AGGGCAGTATCACTCAGCCAA	0.537000													6	34					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222207	140222207	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr5:140222207C>T	ENST00000531613.1	+	1	1301	c.1301C>T	c.(1300-1302)tCg>tTg	p.S434L	PCDHA6_ENST00000529310.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA8_ENST00000378123.3_Missense_Mutation_p.S434L|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA6_ENST00000527624.1_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCTCGCCTTCGCTGTGGGCC	0.627000													50	48					0	0	1	0	0
ZSWIM4	65249	broad.mit.edu	37	19	13934200	13934200	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr19:13934200C>T	ENST00000254323.2	+	10	1939	c.1750C>T	c.(1750-1752)Cat>Tat	p.H584Y	ZSWIM4_ENST00000440752.2_Missense_Mutation_p.H418Y	NM_023072.2	NP_075560.2	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	584							zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			TGGAGAACCTCATCCCAGCCC	0.597000													9	20					0	0	1	0	0
CDH17	1015	broad.mit.edu	37	8	95164212	95164212	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr8:95164212C>T	ENST00000027335.3	-	13	1804	c.1680G>A	c.(1678-1680)gtG>gtA	p.V560V	CDH17_ENST00000450165.2_Silent_p.V560V|CDH17_ENST00000441892.2_Silent_p.V346V	NM_004063.3	NP_004054.3	Q12864	CAD17_HUMAN	cadherin 17, LI cadherin (liver-intestine)	560	Cadherin 5.					integral to membrane	calcium ion binding			NS(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(4)|stomach(2)	52	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			GTGCTTCATTCACATCTGTCA	0.438000													9	80					0	0	1	0	0
TMEM66	51669	broad.mit.edu	37	8	29923530	29923530	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr8:29923530G>C	ENST00000256255.6	-	5	1225	c.968C>G	c.(967-969)tCa>tGa	p.S323*	TMEM66_ENST00000545648.1_Nonsense_Mutation_p.S151*|TMEM66_ENST00000536273.1_Nonsense_Mutation_p.S151*	NM_016127.4	NP_057211.4	Q96BY9	TMM66_HUMAN	transmembrane protein 66	323						integral to membrane				endometrium(2)|large_intestine(1)|lung(11)	14				KIRC - Kidney renal clear cell carcinoma(542;0.0993)|Kidney(114;0.119)		TTTCGTGTCTGAGTTTGAACA	0.458000													14	24					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32953974	32953974	+	Missense_Mutation	SNP	C	C	T	rs80359156		TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr13:32953974C>T	ENST00000544455.1	+	23	9268	c.9041C>T	c.(9040-9042)tCa>tTa	p.S3014L	BRCA2_ENST00000380152.3_Missense_Mutation_p.S3014L	NM_000059.3	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	3014					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		CTTGCAACTTCAAAATCTAAA	0.323000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			7	30					0	0	1	0	0
FAM21C	253725	broad.mit.edu	37	10	46250443	46250443	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr10:46250443G>C	ENST00000336378.4	+	15	1418	c.1300G>C	c.(1300-1302)Gag>Cag	p.E434Q	FAM21C_ENST00000537517.1_Missense_Mutation_p.E410Q|FAM21C_ENST00000374362.2_Missense_Mutation_p.E434Q|FAM21C_ENST00000540872.1_Missense_Mutation_p.E434Q|FAM21C_ENST00000359860.4_Missense_Mutation_p.E378Q	NM_015262.2	NP_056077.2	A8K5W5	A8K5W5_HUMAN	family with sequence similarity 21, member C	434								p.E433Q(1)		central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	28						ACAGAAGCCTGAGCAGCCCAC	0.552000													5	39					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58207788	58207788	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr13:58207788G>A	ENST00000377918.3	+	1	1134	c.1108G>A	c.(1108-1110)Gtc>Atc	p.V370I		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	370	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TCCCGGCACCGTCATCGCCCT	0.701000													3	50					0	0	1	0	0
LPCAT3	10162	broad.mit.edu	37	12	7090329	7090329	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr12:7090329C>G	ENST00000261407.4	-	6	599	c.514G>C	c.(514-516)Gag>Cag	p.E172Q		NM_005768.5	NP_005759.4	Q6P1A2	MBOA5_HUMAN	lysophosphatidylcholine acyltransferase 3	172					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(4)|ovary(1)|skin(2)	17						TTCTGTTGCTCAGAGGACAAG	0.502000													12	26					0	0	1	0	0
AK2	204	broad.mit.edu	37	1	33478907	33478907	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:33478907C>G	ENST00000373449.2	-	6	636	c.595G>C	c.(595-597)Gag>Cag	p.E199Q	AK2_ENST00000354858.6_Missense_Mutation_p.E199Q|RP1-117O3.2_ENST00000427524.1_RNA|AK2_ENST00000548033.1_Missense_Mutation_p.E157Q|AK2_ENST00000480134.1_3'UTR|AK2_ENST00000467905.1_Missense_Mutation_p.E199Q	NM_001199199.1|NM_013411.4	NP_001186128.1|NP_037543.1	P54819	KAD2_HUMAN	adenylate kinase 2	199					nucleobase, nucleoside and nucleotide interconversion	mitochondrial intermembrane space	adenylate kinase activity|ATP binding			kidney(1)|large_intestine(2)|lung(4)|skin(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				CTGTAGTACTCTATGAGTGGG	0.537000													19	40					0	0	1	0	0
SERINC3	10955	broad.mit.edu	37	20	43142550	43142550	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr20:43142550C>G	ENST00000342374.4	-	2	328	c.171G>C	c.(169-171)caG>caC	p.Q57H	SERINC3_ENST00000468234.1_5'UTR|SERINC3_ENST00000541235.1_Missense_Mutation_p.Q2H|SERINC3_ENST00000255175.1_Missense_Mutation_p.Q57H	NM_006811.2	NP_006802.1	Q13530	SERC3_HUMAN	serine incorporator 3	57						integral to membrane|plasma membrane	protein binding			endometrium(4)|large_intestine(2)|lung(8)|skin(3)|urinary_tract(1)	18		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			TCTCTTTTCTCTGCATGATAT	0.368000													18	111					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25488583	25488583	+	RNA	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr15:25488583C>T	ENST00000453082.2	+	0	2211					NR_003343.1																						GATGGTGAGACGGGAGGAAGA	0.602000													12	18					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104156096	104156096	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr12:104156096C>T	ENST00000388887.2	+	67	7608	c.7404C>T	c.(7402-7404)atC>atT	p.I2468I	RP11-341G23.4_ENST00000551299.1_RNA	NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	2468					angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						TCTTTGCCATCATCCTGGTGA	0.488000													12	58					0	0	1	0	0
SLC25A17	10478	broad.mit.edu	37	22	41190579	41190579	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr22:41190579C>G	ENST00000435456.2	-	3	254	c.121G>C	c.(121-123)Gag>Cag	p.E41Q	SLC25A17_ENST00000544408.1_Missense_Mutation_p.E4Q|SLC25A17_ENST00000542412.1_Intron|SLC25A17_ENST00000491545.1_5'UTR	NM_006358.2	NP_006349.1	O43808	PM34_HUMAN	solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17	41					fatty acid alpha-oxidation	integral to plasma membrane|mitochondrial inner membrane|peroxisomal membrane	adenine nucleotide transmembrane transporter activity|protein binding			central_nervous_system(1)|large_intestine(4)|lung(2)|skin(1)	8						TTTCTTTTCTCATCAACTACA	0.373000													23	50					0	0	1	0	0
MAP4K5	11183	broad.mit.edu	37	14	50901239	50901239	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr14:50901239C>T	ENST00000013125.4	-	27	2355	c.2037G>A	c.(2035-2037)gtG>gtA	p.V679V		NM_006575.4|NM_198794.2	NP_006566.2|NP_942089.1	Q9Y4K4	M4K5_HUMAN	mitogen-activated protein kinase kinase kinase kinase 5	679	CNH.				activation of JUN kinase activity	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15	all_epithelial(31;0.000415)|Breast(41;0.0102)					GTTCAGGTATCACCAGCATTT	0.373000													4	11					0	0	1	0	0
CNST	163882	broad.mit.edu	37	1	246797835	246797835	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:246797835G>A	ENST00000366513.4	+	6	1033	c.764G>A	c.(763-765)gGa>gAa	p.G255E	CNST_ENST00000483271.1_3'UTR|CNST_ENST00000366512.3_Missense_Mutation_p.G255E	NM_152609.2	NP_689822.2	Q6PJW8	CNST_HUMAN	consortin, connexin sorting protein	255					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|urinary_tract(2)	28						TCAGAAAAGGGATTTAATGGT	0.328000													17	43					0	0	1	0	0
LNPEP	4012	broad.mit.edu	37	5	96363481	96363481	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr5:96363481C>T	ENST00000231368.5	+	17	3601	c.2909C>T	c.(2908-2910)tCa>tTa	p.S970L	LNPEP_ENST00000395770.3_Missense_Mutation_p.S956L	NM_005575.2	NP_005566.2	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase	970					cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	34		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		GTTGCTGGATCAACTTACCTG	0.433000													11	54					0	0	1	0	0
LOC101927079	101927079	broad.mit.edu	37	15	22332570	22332570	+	RNA	SNP	T	T	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr15:22332570T>C	ENST00000558896.1	+	0	377																											CCCATGCTCATCTGCTCCAAT	0.398000													7	188					0	0	1	0	0
RAD23A	5886	broad.mit.edu	37	19	13058772	13058772	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr19:13058772C>G	ENST00000586534.1	+	2	244	c.183C>G	c.(181-183)atC>atG	p.I61M	RAD23A_ENST00000588826.2_3'UTR|RAD23A_ENST00000592268.1_Missense_Mutation_p.I61M|RAD23A_ENST00000316856.3_Missense_Mutation_p.I61M|RAD23A_ENST00000541222.1_5'UTR			P54725	RD23A_HUMAN	RAD23 homolog A (S. cerevisiae)	61	Ubiquitin-like.				interspecies interaction between organisms|nucleotide-excision repair|positive regulation of viral genome replication|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)|skin(1)	12						ATGTCCCTATCAGGGACTATC	0.547000								Nucleotide excision repair (NER)					24	29					0	0	1	0	0
HIST1H3I	8354	broad.mit.edu	37	6	27839802	27839802	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr6:27839802C>T	ENST00000328488.2	-	1	297	c.292G>A	c.(292-294)Gag>Aag	p.E98K		NM_003533.2	NP_003524.1	P68431	H31_HUMAN	histone cluster 1, H3i	98					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			endometrium(2)|kidney(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						AGGTAGGCCTCGCAAGCCTCC	0.572000													59	45					0	0	1	0	0
KRT38	8687	broad.mit.edu	37	17	39596841	39596841	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr17:39596841C>T	ENST00000246646.3	-	1	332	c.333G>A	c.(331-333)ctG>ctA	p.L111L		NM_006771.3	NP_006762.3	O76015	KRT38_HUMAN	keratin 38	111	Coil 1A.|Rod.					intermediate filament	structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	29		Breast(137;0.000496)				GGCGGTCATTCAGGAACTGCA	0.582000													48	98					0	0	1	0	0
SHC1	6464	broad.mit.edu	37	1	154942951	154942951	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:154942951G>C	ENST00000448116.2	-	1	272	c.52C>G	c.(52-54)Ctg>Gtg	p.L18V	SHC1_ENST00000606391.1_Splice_Site_p.L18V|SHC1_ENST00000368450.1_Intron|SHC1_ENST00000368445.5_Missense_Mutation_p.L18V|SHC1_ENST00000368453.4_Intron|SHC1_ENST00000368449.4_Splice_Site	NM_001130040.1	NP_001123512.1	P29353	SHC1_HUMAN	SHC (Src homology 2 domain containing) transforming protein 1	18					activation of MAPK activity|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|positive regulation of DNA replication|Ras protein signal transduction|regulation of epidermal growth factor receptor activity|regulation of growth	cytosol|mitochondrial matrix|Shc-EGFR complex	epidermal growth factor receptor binding|insulin receptor binding|insulin-like growth factor receptor binding|phospholipid binding|protein binding|transmembrane receptor protein tyrosine kinase adaptor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(8)|prostate(1)|skin(1)	20	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			AGCGATGACAGAGACTCATTC	0.637000													14	27					0	0	1	0	0
TMEM52	339456	broad.mit.edu	37	1	1849592	1849592	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:1849592G>A	ENST00000378602.3	-	2	554	c.314C>T	c.(313-315)tCc>tTc	p.S105F	TMEM52_ENST00000310991.3_Missense_Mutation_p.S120F			Q8NDY8	TMM52_HUMAN	transmembrane protein 52	120						integral to membrane				NS(1)|prostate(1)|stomach(1)	3	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.82e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.75e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GTACTGCACGGAGCTGTAGGC	0.652000													23	26					0	0	1	0	0
VCPIP1	80124	broad.mit.edu	37	8	67576631	67576631	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr8:67576631C>T	ENST00000310421.4	-	1	2821	c.2563G>A	c.(2563-2565)Gct>Act	p.A855T		NM_025054.4	NP_079330.2	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex interacting protein 1	855					protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity			breast(7)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(6)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)			CCACCTTCAGCTTTACTTTTT	0.433000													57	60					0	0	1	0	0
UNC45A	55898	broad.mit.edu	37	15	91486220	91486220	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr15:91486220G>A	ENST00000394275.2	+	11	1725	c.890G>A	c.(889-891)cGa>cAa	p.R297Q	UNC45A_ENST00000418476.2_Missense_Mutation_p.R312Q|UNC45A_ENST00000553671.2_3'UTR	NM_001039675.1	NP_001034764.1	Q9H3U1	UN45A_HUMAN	unc-45 homolog A (C. elegans)	312					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			GGCCAAGGCCGAGACAATGCC	0.567000													30	65					0	0	1	0	0
PARN	5073	broad.mit.edu	37	16	14704555	14704555	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr16:14704555G>C	ENST00000437198.2	-	7	641	c.500C>G	c.(499-501)tCa>tGa	p.S167*	PARN_ENST00000566021.1_5'UTR|PARN_ENST00000341484.7_Nonsense_Mutation_p.S106*|PARN_ENST00000420015.2_Nonsense_Mutation_p.S121*|PARN_ENST00000539279.1_Intron	NM_001134477.2|NM_002582.3	NP_001127949.1|NP_002573.1	O95453	PARN_HUMAN	poly(A)-specific ribonuclease	167					female gamete generation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|RNA modification	cytosol|nucleolus	metal ion binding|mRNA 3'-UTR binding|nucleotide binding|poly(A)-specific ribonuclease activity|protein binding			cervix(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|urinary_tract(1)	21						AGGACATTTTGAAGTGTTAGG	0.383000													61	69					0	0	1	0	0
GRK6	2870	broad.mit.edu	37	5	176860650	176860650	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr5:176860650C>T	ENST00000355472.5	+	8	879	c.711C>T	c.(709-711)atC>atT	p.I237I	GRK6_ENST00000355958.5_Silent_p.I237I|GRK6_ENST00000528793.1_Silent_p.I237I|GRK6_ENST00000393576.3_Silent_p.I237I|GRK6_ENST00000507633.1_Silent_p.I237I	NM_001004106.2|NM_002082.3	NP_001004106.1|NP_002073.2	P43250	GRK6_HUMAN	G protein-coupled receptor kinase 6	237	Protein kinase.				regulation of G-protein coupled receptor protein signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(5)|stomach(1)	25	all_cancers(89;1.15e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGAAGCAGATCCTGGAGAAAG	0.572000													22	17					0	0	1	0	0
PUS3	83480	broad.mit.edu	37	11	125765527	125765527	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr11:125765527G>A	ENST00000227474.3	-	3	633	c.536C>T	c.(535-537)cCt>cTt	p.P179L	HYLS1_ENST00000425380.2_Intron|HYLS1_ENST00000526028.1_Intron|HYLS1_ENST00000356438.3_Intron|PUS3_ENST00000530811.1_Missense_Mutation_p.P179L	NM_001271985.1|NM_031307.3	NP_001258914.1|NP_112597	Q9BZE2	PUS3_HUMAN	pseudouridylate synthase 3	179						nucleus	RNA binding			NS(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	10	all_hematologic(175;0.177)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.131)|all_lung(97;0.139)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.043)		TGGTTCTACAGGGGCCCAGGC	0.473000													47	47					0	0	1	0	0
TMEM184B	25829	broad.mit.edu	37	22	38617497	38617497	+	Silent	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr22:38617497G>A	ENST00000361906.3	-	9	1411	c.1203C>T	c.(1201-1203)ctC>ctT	p.L401L	TMEM184B_ENST00000361684.4_Silent_p.L401L|TMEM184B_ENST00000504337.1_5'UTR	NM_001195072.1|NM_012264.4	NP_001182001.1|NP_036396.2	Q9Y519	T184B_HUMAN	transmembrane protein 184B	401						integral to membrane				endometrium(1)|large_intestine(2)|lung(2)|skin(2)|upper_aerodigestive_tract(1)	8	Melanoma(58;0.045)					CATCAGAGCTGAGCAGGAGAG	0.682000													23	9					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104131455	104131455	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr12:104131455G>A	ENST00000388887.2	+	53	5798	c.5594G>A	c.(5593-5595)cGg>cAg	p.R1865Q		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	1865	FAS1 6.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						ATTGTGCAGCGGGAGCTCTTG	0.483000													8	36					0	0	1	0	0
SEPP1	6414	broad.mit.edu	37	5	42808290	42808290	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr5:42808290G>C	ENST00000514985.1	-	2	422	c.166C>G	c.(166-168)Caa>Gaa	p.Q56E	SEPP1_ENST00000511224.1_Missense_Mutation_p.Q56E|SEPP1_ENST00000509276.1_5'UTR|SEPP1_ENST00000506577.1_Missense_Mutation_p.Q56E|SEPP1_ENST00000507920.1_Missense_Mutation_p.Q56E	NM_005410.2	NP_005401.3	P49908	SEPP1_HUMAN	selenoprotein P, plasma, 1	56					response to oxidative stress	extracellular region	selenium binding			kidney(10)|large_intestine(1)|lung(4)	15						CAGCTGGCTTGAAGAAGAGCA	0.453000													5	32					0	0	1	0	0
RPH3A	22895	broad.mit.edu	37	12	113285551	113285551	+	Missense_Mutation	SNP	G	G	T	rs146502002	byFrequency	TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr12:113285551G>T	ENST00000389385.4	+	5	631	c.134G>T	c.(133-135)aGg>aTg	p.R45M	RPH3A_ENST00000447659.2_Intron|RPH3A_ENST00000415485.3_Missense_Mutation_p.R45M|RPH3A_ENST00000551052.1_Missense_Mutation_p.R41M|RPH3A_ENST00000548866.1_Intron|RPH3A_ENST00000420983.2_Missense_Mutation_p.R45M|RPH3A_ENST00000543106.2_Missense_Mutation_p.R45M	NM_001143854.1|NM_014954.3	NP_001137326.1|NP_055769.2	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog (mouse)	45	RabBD.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)|ovary(3)|prostate(4)|skin(6)|urinary_tract(1)	47				BRCA - Breast invasive adenocarcinoma(302;0.00453)		GACAGGCAGAGGAAGCAGGAA	0.532000													8	29					0.000157383	0.000160135	1	1	0
HYDIN	54768	broad.mit.edu	37	16	71054106	71054106	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr16:71054106C>T	ENST00000393567.2	-	22	3451	c.3301G>A	c.(3301-3303)Gat>Aat	p.D1101N	HYDIN_ENST00000448089.2_Missense_Mutation_p.D1053N	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	1101										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				AGGGATTTATCAGTCTCACAT	0.507000													7	15					0	0	1	0	0
ACO2	50	broad.mit.edu	37	22	41916247	41916247	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr22:41916247G>A	ENST00000396512.3	+	9	1197	c.1180G>A	c.(1180-1182)Gag>Aag	p.E394K	ACO2_ENST00000216254.4_Missense_Mutation_p.E369K|ACO2_ENST00000466237.1_3'UTR			Q99798	ACON_HUMAN	aconitase 2, mitochondrial	369					citrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron ion binding|isocitrate hydro-lyase (cis-aconitate-forming) activity			breast(3)|endometrium(5)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	23						CAAGGTGGCAGAGAAGGAAGG	0.577000													19	18					0	0	1	0	0
GLRA4	441509	broad.mit.edu	37	X	102978790	102978790	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chrX:102978790C>G	ENST00000372617.4	-	5	991	c.571G>C	c.(571-573)Gag>Cag	p.E191Q		NM_001024452.2	NP_001019623.2	Q5JXX5	GLRA4_HUMAN	glycine receptor, alpha 4	191						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	21						TTACAGCTCTCAAGCTGCATC	0.498000													8	6					0	0	1	0	0
BRAP	8315	broad.mit.edu	37	12	112097055	112097055	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr12:112097055T>C	ENST00000419234.4	-	8	1260	c.1067A>G	c.(1066-1068)tAt>tGt	p.Y356C	BRAP_ENST00000539060.1_Missense_Mutation_p.Y177C|BRAP_ENST00000327551.6_Missense_Mutation_p.Y326C	NM_006768.3	NP_006759.3	Q7Z569	BRAP_HUMAN	BRCA1 associated protein	356				Y -> H (in Ref. 5; AAB88538).	MAPKKK cascade|negative regulation of signal transduction|Ras protein signal transduction	cytoplasm|ubiquitin ligase complex	identical protein binding|nuclear localization sequence binding|nucleotide binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	20						CTGCATGGCATACGTGTGCTG	0.458000													16	38					0	0	1	0	0
HLCS	3141	broad.mit.edu	37	21	38309557	38309557	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr21:38309557C>A	ENST00000399120.1	-	5	1418	c.188G>T	c.(187-189)aGa>aTa	p.R63I	HLCS_ENST00000336648.4_Missense_Mutation_p.R63I	NM_001242784.1	NP_001229713.1	P50747	BPL1_HUMAN	holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)	63					cell proliferation|histone biotinylation|response to biotin	chromatin|cytosol|mitochondrion|nuclear lamina|nuclear matrix	ATP binding|biotin binding|biotin-[acetyl-CoA-carboxylase] ligase activity|biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity|biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity|enzyme binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(46;0.0422)			Biotin(DB00121)	TGGGTCATCTCTGCCAACATG	0.557000													21	39					2.4624e-09	2.61517e-09	1	1	0
RICTOR	253260	broad.mit.edu	37	5	38950364	38950364	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr5:38950364C>G	ENST00000357387.3	-	31	3616	c.3586G>C	c.(3586-3588)Gaa>Caa	p.E1196Q	RICTOR_ENST00000296782.5_Missense_Mutation_p.E1196Q	NM_152756.3	NP_689969.2	Q6R327	RICTR_HUMAN	RPTOR independent companion of MTOR, complex 2	1196					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|prostate(3)|skin(5)	75	all_lung(31;0.000396)					CTTGTATTTTCTCTGTGATTC	0.378000													36	122					0	0	1	0	0
KRT38	8687	broad.mit.edu	37	17	39596864	39596864	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr17:39596864C>G	ENST00000246646.3	-	1	309	c.310G>C	c.(310-312)Gag>Cag	p.E104Q		NM_006771.3	NP_006762.3	O76015	KRT38_HUMAN	keratin 38	104	Head.					intermediate filament	structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	29		Breast(137;0.000496)				GTCTCCTTCTCATGGCCATTC	0.582000													41	90					0	0	1	0	0
ZNF318	24149	broad.mit.edu	37	6	43323422	43323422	+	Silent	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr6:43323422G>A	ENST00000361428.2	-	4	1727	c.1650C>T	c.(1648-1650)tcC>tcT	p.S550S	ZNF318_ENST00000318149.3_Silent_p.S550S	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	550					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			GCTTTGGTACGGATTCTGCCT	0.478000													52	255					0	0	1	0	0
KIAA2013	90231	broad.mit.edu	37	1	11982702	11982702	+	Silent	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:11982702G>A	ENST00000376572.3	-	2	2063	c.1878C>T	c.(1876-1878)ttC>ttT	p.F626F	KIAA2013_ENST00000376576.3_Silent_p.F626F	NM_138346.2	NP_612355.1	Q8IYS2	K2013_HUMAN	KIAA2013	626						integral to membrane				endometrium(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	7	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00149)|all_lung(284;0.00189)|Breast(348;0.00586)|Colorectal(325;0.0062)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0556)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CCTTACTCCTGAAGAGGGGCT	0.597000													6	5					0	0	1	0	0
GPRIN2	9721	broad.mit.edu	37	10	46999073	46999073	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr10:46999073G>C	ENST00000374314.4	+	1	1148	c.193G>C	c.(193-195)Gag>Cag	p.E65Q	GPRIN2_ENST00000374317.1_Missense_Mutation_p.E65Q			O60269	GRIN2_HUMAN	G protein regulated inducer of neurite outgrowth 2	65										breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	18						CCCGGAGGAAGAGGGGAACCC	0.692000													14	66					0	0	1	0	0
CCNE2	9134	broad.mit.edu	37	8	95905116	95905116	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr8:95905116C>T	ENST00000520509.1	-	5	499	c.247G>A	c.(247-249)Gat>Aat	p.D83N	CCNE2_ENST00000308108.4_Missense_Mutation_p.D83N|CCNE2_ENST00000396133.3_Missense_Mutation_p.D83N|CCNE2_ENST00000523476.1_5'UTR			O96020	CCNE2_HUMAN	cyclin E2	83					cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	cytosol|nucleoplasm	protein kinase binding			cervix(1)|endometrium(2)|large_intestine(3)|lung(4)|prostate(1)	11	Breast(36;8.75e-07)					CTGGAGAAATCACTTGTTCCT	0.303000													41	29					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39452398	39452398	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr13:39452398G>A	ENST00000280481.7	+	22	9015	c.8799G>A	c.(8797-8799)atG>atA	p.M2933I		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2933					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		ATAGTCCAATGAATGCAGAAT	0.408000													22	57					0	0	1	0	0
ATP1B3	483	broad.mit.edu	37	3	141640822	141640822	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr3:141640822G>A	ENST00000539728.1	+	8	857	c.564G>A	c.(562-564)atG>atA	p.M188I	ATP1B3_ENST00000484727.1_3'UTR|ATP1B3_ENST00000286371.3_Missense_Mutation_p.E196K|ATP1B3_ENST00000462082.1_Intron			P54709	AT1B3_HUMAN	ATPase, Na+/K+ transporting, beta 3 polypeptide	0					ATP biosynthetic process|blood coagulation|leukocyte migration	melanosome|sodium:potassium-exchanging ATPase complex	protein binding|sodium:potassium-exchanging ATPase activity			cervix(1)|endometrium(1)|lung(2)	4						ACTTCAGAATGAAGATATACC	0.279000													26	52					0	0	1	0	0
CXorf58	254158	broad.mit.edu	37	X	23956728	23956728	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chrX:23956728C>T	ENST00000379211.3	+	8	1399	c.850C>T	c.(850-852)Ctg>Ttg	p.L284L		NM_001169574.1|NM_152761.2	NP_001163045.1|NP_689974.2	Q96LI9	CX058_HUMAN	chromosome X open reading frame 58	284								p.L284M(1)		breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(2)|prostate(1)	14						AGTTAAATTTCTGGGTCGTCG	0.338000													40	36					0	0	1	0	0
NBEAL1	65065	broad.mit.edu	37	2	204003357	204003357	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr2:204003357G>C	ENST00000449802.1	+	30	4980	c.4647G>C	c.(4645-4647)atG>atC	p.M1549I		NM_001114132.1	NP_001107604.1	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1	1549							binding			NS(1)|breast(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						TAGAGGATATGATGCTGCTCT	0.338000													15	67					0	0	1	0	0
UNC45A	55898	broad.mit.edu	37	15	91491502	91491502	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr15:91491502C>T	ENST00000394275.2	+	15	2516	c.1681C>T	c.(1681-1683)Cag>Tag	p.Q561*	UNC45A_ENST00000418476.2_Nonsense_Mutation_p.Q576*	NM_001039675.1	NP_001034764.1	Q9H3U1	UN45A_HUMAN	unc-45 homolog A (C. elegans)	576					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			AGCTCTGTTCCAGCTCAGCAG	0.592000													33	59					0	0	1	0	0
MEGF6	1953	broad.mit.edu	37	1	3424435	3424435	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:3424435C>G	ENST00000356575.4	-	14	1939	c.1713G>C	c.(1711-1713)caG>caC	p.Q571H	MEGF6_ENST00000294599.4_Missense_Mutation_p.Q466H	NM_001409.3	NP_001400.3	O75095	MEGF6_HUMAN	multiple EGF-like-domains 6	571	EGF-like 10.					extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		TCCCACCATTCTGACAGCTGC	0.602000													23	44					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10447069	10447069	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr17:10447069C>T	ENST00000245503.5	-	8	1084	c.700G>A	c.(700-702)Ggc>Agc	p.G234S	CTC-297N7.11_ENST00000587182.2_RNA|MYH2_ENST00000397183.2_Missense_Mutation_p.G234S|MYH2_ENST00000532183.2_Missense_Mutation_p.G234S	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	234	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TTGGCGTTGCCAAAGGCCTCC	0.488000													35	31					0	0	1	0	0
OR5T2	219464	broad.mit.edu	37	11	56000321	56000321	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr11:56000321G>A	ENST00000313264.4	-	1	416	c.341C>T	c.(340-342)tCa>tTa	p.S114L		NM_001004746.1	NP_001004746.1	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T, member 2	114					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(3)	41	Esophageal squamous(21;0.00448)					GGTAATAACTGAGGAATAGCA	0.378000													23	16					0	0	1	0	0
HRSP12	10247	broad.mit.edu	37	8	99118185	99118185	+	Silent	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr8:99118185G>A	ENST00000254878.3	-	4	420	c.276C>T	c.(274-276)gtC>gtT	p.V92V		NM_005836.2	NP_005827.1	P52758	UK114_HUMAN	heat-responsive protein 12	92					regulation of translational termination	nucleus	endonuclease activity			large_intestine(3)|lung(1)|ovary(1)|urinary_tract(1)	6	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.214)			AGATTTCATTGACAGTATTGA	0.303000													17	147					0	0	1	0	0
SPARC	6678	broad.mit.edu	37	5	151047138	151047138	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr5:151047138C>T	ENST00000231061.4	-	7	788	c.475G>A	c.(475-477)Gag>Aag	p.E159K	SPARC_ENST00000537849.1_5'UTR	NM_003118.3	NP_003109.1	P09486	SPRC_HUMAN	secreted protein, acidic, cysteine-rich (osteonectin)	159					ossification|platelet activation|platelet degranulation|signal transduction	basement membrane|extracellular space|platelet alpha granule lumen	calcium ion binding|collagen binding			central_nervous_system(3)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	15		Medulloblastoma(196;0.109)|all_hematologic(541;0.122)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)	OV - Ovarian serous cystadenocarcinoma(192;0.00118)	Becaplermin(DB00102)	TCGGTCAGCTCAGAGTCCAGG	0.617000													10	12					0	0	1	0	0
NFKBIL1	4795	broad.mit.edu	37	6	31516150	31516150	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr6:31516150G>T	ENST00000376148.4	+	2	382	c.268G>T	c.(268-270)Gac>Tac	p.D90Y	NFKBIL1_ENST00000376145.4_Missense_Mutation_p.D90Y	NM_005007.3	NP_004998.3	Q9UBC1	IKBL1_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1	90					cytoplasmic sequestering of transcription factor		protein binding			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|skin(1)	7						GCTCGGGGCTGACCCTGCCCA	0.687000													7	6					0.00198382	0.00201147	1	1	0
GCOM1	145781	broad.mit.edu	37	15	57917989	57917989	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr15:57917989C>T	ENST00000574161.1	+	5	543	c.424C>T	c.(424-426)Cag>Tag	p.Q142*	MYZAP_ENST00000267853.5_Nonsense_Mutation_p.Q142*|GCOM1_ENST00000587652.1_Nonsense_Mutation_p.Q142*|GCOM1_ENST00000380568.3_Nonsense_Mutation_p.Q142*|GCOM1_ENST00000396180.1_Nonsense_Mutation_p.Q111*|GCOM1_ENST00000380561.2_Nonsense_Mutation_p.Q111*|GCOM1_ENST00000572390.1_Nonsense_Mutation_p.Q142*|GCOM1_ENST00000380569.2_Nonsense_Mutation_p.Q142*|GCOM1_ENST00000380560.2_Intron|MYZAP_ENST00000380565.4_Nonsense_Mutation_p.Q142*|POLR2M_ENST00000380563.2_5'UTR	NM_001018100.3	NP_001018110.1	P0CAP1	GCOM1_HUMAN		142					intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				endometrium(1)|kidney(2)|large_intestine(9)|liver(1)|lung(1)|ovary(1)|skin(2)|stomach(1)	18						TTCCCATGCTCAGCAGGAGTA	0.478000													20	43					0	0	1	0	0
PARG	8505	broad.mit.edu	37	10	51093329	51093329	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr10:51093329C>T	ENST00000402038.3	-	4	294	c.295G>A	c.(295-297)Gca>Aca	p.A99T		NM_003631.2	NP_003622.2	Q86W56	PARG_HUMAN	poly (ADP-ribose) glycohydrolase	584					carbohydrate metabolic process	nucleus	poly(ADP-ribose) glycohydrolase activity	p.A584T(1)		endometrium(5)|kidney(2)|lung(1)|ovary(2)	10				Epithelial(53;0.213)		TGAGCTTCTGCTTCTTCAAGT	0.318000													4	58					0	0	1	0	0
KCNJ15	3772	broad.mit.edu	37	21	39671931	39671931	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr21:39671931C>T	ENST00000328656.4	+	4	1051	c.748C>T	c.(748-750)Ctg>Ttg	p.L250L	KCNJ15_ENST00000398934.1_Silent_p.L250L|KCNJ15_ENST00000398932.1_Silent_p.L250L|KCNJ15_ENST00000398930.1_Silent_p.L250L|KCNJ15_ENST00000398938.2_Silent_p.L250L	NM_001276437.1|NM_001276438.1|NM_001276439.1|NM_002243.3	NP_001263366.1|NP_001263367.1|NP_001263368.1|NP_002234.2	Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 15						synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	24						CTTCCTCATTCTGCCCATGAC	0.557000													16	25					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94528162	94528162	+	Silent	SNP	C	C	T	rs61752400		TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:94528162C>T	ENST00000370225.3	-	13	1994	c.1908G>A	c.(1906-1908)caG>caA	p.Q636Q	ABCA4_ENST00000535735.1_Silent_p.Q636Q	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	636			Q -> H (in STGD1).		phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GGTAGGGCATCTGCTGGAGGT	0.597000													9	32					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33291385	33291385	+	Missense_Mutation	SNP	G	G	A	rs150591358		TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr14:33291385G>A	ENST00000280979.4	+	13	4536	c.4366G>A	c.(4366-4368)Gaa>Aaa	p.E1456K	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1456					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		CTGTTTGGGAGAAGAATTACA	0.363000													19	36					0	0	1	0	0
TTC16	158248	broad.mit.edu	37	9	130493029	130493029	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr9:130493029C>A	ENST00000373289.3	+	14	2047	c.1967C>A	c.(1966-1968)tCg>tAg	p.S656*	TTC16_ENST00000489226.1_3'UTR	NM_144965.1	NP_659402.1	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	656							binding			central_nervous_system(2)|endometrium(3)|lung(7)|ovary(3)|pancreas(2)|prostate(4)|skin(1)	22						ACGCAATCCTCGGACTCTGGG	0.567000													16	16					2.31682e-05	2.38232e-05	1	1	0
SYNE3	161176	broad.mit.edu	37	14	95932474	95932474	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr14:95932474C>T	ENST00000334258.5	-	3	435	c.421G>A	c.(421-423)Gag>Aag	p.E141K	SYNE3_ENST00000557275.1_Missense_Mutation_p.E141K|SYNE3_ENST00000553340.1_Missense_Mutation_p.E141K	NM_152592.3	NP_689805.3			spectrin repeat containing, nuclear envelope family member 3											breast(1)|endometrium(2)|lung(25)	28						AGCTGGAGCTCGATGTGGGGC	0.627000													32	56					0	0	1	0	0
DAB2	1601	broad.mit.edu	37	5	39377048	39377048	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr5:39377048G>C	ENST00000545653.1	-	11	2308	c.1778C>G	c.(1777-1779)tCt>tGt	p.S593C	DAB2_ENST00000320816.6_Missense_Mutation_p.S614C|DAB2_ENST00000509337.1_Missense_Mutation_p.S593C|DAB2_ENST00000339788.6_Missense_Mutation_p.S396C	NM_001244871.1	NP_001231800.1	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	614					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			GACCAGGAGAGAGGAGTGCAT	0.547000											OREG0016586	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	73					0	0	1	0	0
DPP8	54878	broad.mit.edu	37	15	65756223	65756223	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr15:65756223G>A	ENST00000341861.5	-	15	3475	c.1895C>T	c.(1894-1896)cCt>cTt	p.P632L	DPP8_ENST00000321118.7_Missense_Mutation_p.P632L|DPP8_ENST00000339244.5_Missense_Mutation_p.P459L|DPP8_ENST00000559233.1_Missense_Mutation_p.P632L|DPP8_ENST00000321147.6_Missense_Mutation_p.P632L|DPP8_ENST00000358939.4_Missense_Mutation_p.P616L|DPP8_ENST00000300141.6_Missense_Mutation_p.P616L	NM_197960.2	NP_932064.1	Q6V1X1	DPP8_HUMAN	dipeptidyl-peptidase 8	632					immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			NS(1)|breast(2)|endometrium(3)|large_intestine(11)|lung(11)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						AATTTCTGGAGGAGTATAGTC	0.388000													14	43					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216270481	216270481	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:216270481C>G	ENST00000366943.2	-	22	5088	c.4702G>C	c.(4702-4704)Gag>Cag	p.E1568Q	USH2A_ENST00000307340.3_Missense_Mutation_p.E1568Q			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1568	Laminin G-like 1.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GCAAAATACTCTTCCTGATTG	0.363000										HNSCC(13;0.011)			33	35					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111164349	111164349	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr13:111164349C>T	ENST00000360467.5	+	48	5256	c.4950C>T	c.(4948-4950)ttC>ttT	p.F1650F		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1650	Collagen IV NC1.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			TAGAGGACTTCCGCGCCACAC	0.622000													30	78					0	0	1	0	0
ST14	6768	broad.mit.edu	37	11	130078553	130078553	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr11:130078553C>T	ENST00000278742.5	+	17	2661	c.2243C>T	c.(2242-2244)aCg>aTg	p.T748M		NM_021978.3	NP_068813.1	Q9Y5Y6	ST14_HUMAN	suppression of tumorigenicity 14 (colon carcinoma)	748	Peptidase S1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|pancreas(2)|prostate(1)|skin(3)	32	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	ATCTGGGTCACGGGCTGGGGA	0.647000													3	18					0	0	1	0	0
KIF14	9928	broad.mit.edu	37	1	200567476	200567476	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:200567476G>A	ENST00000367350.4	-	14	2876	c.2438C>T	c.(2437-2439)tCt>tTt	p.S813F		NM_014875.2	NP_055690.1	Q15058	KIF14_HUMAN	kinesin family member 14	813					microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			NS(1)|breast(5)|central_nervous_system(2)|endometrium(8)|kidney(8)|large_intestine(15)|lung(13)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	61						CAGCATCTCAGATAGTTGTGG	0.343000													17	40					0	0	1	0	0
NUFIP1	26747	broad.mit.edu	37	13	45523962	45523962	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr13:45523962C>G	ENST00000379161.4	-	8	1079	c.1033G>C	c.(1033-1035)Gag>Cag	p.E345Q		NM_012345.2	NP_036477.2	Q9UHK0	NUFP1_HUMAN	nuclear fragile X mental retardation protein interacting protein 1	345					box C/D snoRNP assembly|positive regulation of transcription from RNA polymerase II promoter|RNA processing	actin cytoskeleton|cytosolic ribosome|nuclear matrix|nucleolus|perichromatin fibrils|pre-snoRNP complex|presynaptic active zone|transcription elongation factor complex	DNA binding|identical protein binding|protein binding, bridging|RNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(4)|skin(3)	18		Lung NSC(96;8.23e-05)|Breast(139;0.00378)|Prostate(109;0.0107)|all_hematologic(4;0.014)|Lung SC(185;0.0262)|Hepatocellular(98;0.0524)|Acute lymphoblastic leukemia(4;0.143)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000306)|BRCA - Breast invasive adenocarcinoma(63;0.125)		GGTTTCTCCTCCTTATCAGAC	0.438000													16	28					0	0	1	0	0
PYGB	5834	broad.mit.edu	37	20	25228820	25228820	+	Silent	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr20:25228820G>A	ENST00000216962.4	+	1	116	c.6G>A	c.(4-6)gcG>gcA	p.A2A		NM_002862.3	NP_002853.2	P11216	PYGB_HUMAN	phosphorylase, glycogen; brain	2				AK -> GE (in Ref. 1 and 2).	glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	31					Pyridoxal Phosphate(DB00114)	GCGCGATGGCGAAGCCGCTGA	0.692000													4	43					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103470282	103470282	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr14:103470282G>C	ENST00000361246.2	-	4	718	c.430C>G	c.(430-432)Cag>Gag	p.Q144E		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	144	Protein kinase.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		TTCTCGTCCTGAAAGGCGTAG	0.572000													11	12					0	0	1	0	0
KIAA1958	158405	broad.mit.edu	37	9	115422016	115422016	+	Silent	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr9:115422016G>C	ENST00000337530.6	+	4	2114	c.1818G>C	c.(1816-1818)cgG>cgC	p.R606R	KIAA1958_ENST00000536272.1_Silent_p.R634R	NM_133465.2	NP_597722.1	Q8N8K9	K1958_HUMAN	KIAA1958	606										endometrium(1)|large_intestine(9)|lung(10)|prostate(2)|skin(3)	25						GGGAGAGTCGGAGCGGCTCCA	0.562000													13	8					0	0	1	0	0
NBPF14	25832	broad.mit.edu	37	1	148012531	148012531	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:148012531C>T	ENST00000369219.1	-	12	1444	c.1428G>A	c.(1426-1428)aaG>aaA	p.K476K				Q5TI25	NBPFE_HUMAN	neuroblastoma breakpoint family, member 14	476	NBPF 5.					cytoplasm		p.K476K(2)|p.K476N(1)		NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(23)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	42	all_hematologic(923;0.032)					AGCCAACATGCTTTTCCTCCA	0.443000													3	10					0	0	1	0	0
TOP1	7150	broad.mit.edu	37	20	39704876	39704876	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr20:39704876C>G	ENST00000361337.2	+	4	471	c.221C>G	c.(220-222)tCa>tGa	p.S74*		NM_003286.2	NP_003277.1	P11387	TOP1_HUMAN	topoisomerase (DNA) I	74	Lys-rich.				DNA topological change|interspecies interaction between organisms|phosphorylation|programmed cell death|response to drug	chromosome|nucleolus|nucleoplasm	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity|protein binding			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(115;0.00878)			Irinotecan(DB00762)|Lucanthone(DB04967)|Topotecan(DB01030)	gatggaagctcagaaaagcat	0.388000			T	NUP98	AML*								33	67					0	0	1	0	0
ELF3	1999	broad.mit.edu	37	1	201983137	201983137	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:201983137T>C	ENST00000359651.3	+	7	4178	c.986T>C	c.(985-987)cTg>cCg	p.L329P	ELF3_ENST00000367284.5_Missense_Mutation_p.L329P|ELF3_ENST00000367283.3_Missense_Mutation_p.L329P|RP11-510N19.5_ENST00000504773.1_RNA			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	329					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						TACGAGAAGCTGAGCCGGGCC	0.602000													5	10					0	0	1	0	0
ERO1L	30001	broad.mit.edu	37	14	53110323	53110323	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr14:53110323C>G	ENST00000395686.3	-	16	1595	c.1372G>C	c.(1372-1374)Gaa>Caa	p.E458Q		NM_014584.1	NP_055399.1	Q96HE7	ERO1A_HUMAN	ERO1-like (S. cerevisiae)	458					chaperone mediated protein folding requiring cofactor|electron transport chain|protein thiol-disulfide exchange|response to temperature stimulus|transport	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome	disulfide oxidoreductase activity|flavin adenine dinucleotide binding|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor		ERO1L/FERMT2(2)	breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	12	Breast(41;0.226)					CTGAAGTTTTCTAATTCTTTC	0.303000													9	36					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	62985084	62985084	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr15:62985084G>A	ENST00000561311.1	+	12	1389	c.1159G>A	c.(1159-1161)Gag>Aag	p.E387K	TLN2_ENST00000306829.6_Missense_Mutation_p.E387K			Q9Y4G6	TLN2_HUMAN	talin 2	387	FERM.|Interaction with PIP5K1C (By similarity).				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton	p.E387K(1)		NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						ACAAACCACCGAGGGAGAGCA	0.388000													30	73					0	0	1	0	0
APAF1	317	broad.mit.edu	37	12	99076980	99076980	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr12:99076980C>T	ENST00000357310.1	+	15	2683	c.2106C>T	c.(2104-2106)gtC>gtT	p.V702V	APAF1_ENST00000550527.1_Silent_p.V691V|APAF1_ENST00000547045.1_Silent_p.V702V|APAF1_ENST00000552268.1_Intron|APAF1_ENST00000359972.2_Silent_p.V691V|APAF1_ENST00000551964.1_Silent_p.V702V|APAF1_ENST00000333991.1_Intron|APAF1_ENST00000339433.3_Silent_p.V702V|APAF1_ENST00000549007.1_Silent_p.V702V	NM_181868.1	NP_863658.1	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1	702					activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(1)	42					Adenosine triphosphate(DB00171)	CAGAGCAAGTCAATTGCTGCC	0.378000													9	30					0	0	1	0	0
LOC220729	220729	broad.mit.edu	37	3	197348739	197348739	+	RNA	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr3:197348739G>C	ENST00000418868.1	-	0	520					NR_003266.2																						TAATTTTCTAGCTGTGAAAGA	0.398000													4	93					0	0	1	0	0
ZNF592	9640	broad.mit.edu	37	15	85334051	85334051	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr15:85334051C>G	ENST00000299927.3	+	2	2358	c.2336C>G	c.(2335-2337)tCt>tGt	p.S779C	ZNF592_ENST00000560079.2_Missense_Mutation_p.S779C			Q92610	ZN592_HUMAN	zinc finger protein 592	779					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CTCTGCCGCTCTGCCTACTTC	0.592000													7	85					0	0	1	0	0
SLC44A2	57153	broad.mit.edu	37	19	10747259	10747259	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr19:10747259C>T	ENST00000586078.1	+	15	1603	c.1494C>T	c.(1492-1494)ctC>ctT	p.L498L	SLC44A2_ENST00000335757.5_Silent_p.L498L|SLC44A2_ENST00000407327.4_Silent_p.L496L	NM_020428.3	NP_065161.3	Q8IWA5	CTL2_HUMAN	solute carrier family 44 (choline transporter), member 2	498					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			NS(1)|breast(3)|endometrium(5)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	GCCGGGCGCTCAGGTGGGCTG	0.711000													20	28					0	0	1	0	0
SFXN3	81855	broad.mit.edu	37	10	102795805	102795805	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr10:102795805C>G	ENST00000393459.1	+	5	851	c.378C>G	c.(376-378)ttC>ttG	p.F126L	SFXN3_ENST00000224807.5_Missense_Mutation_p.F130L			Q9BWM7	SFXN3_HUMAN	sideroflexin 3	130					iron ion homeostasis	integral to membrane|mitochondrial membrane	cation transmembrane transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	9		Colorectal(252;0.234)		Epithelial(162;6.98e-09)|all cancers(201;3.55e-07)		ATCAGTCCTTCAATGCCATTG	0.557000													18	20					0	0	1	0	0
SETD6	79918	broad.mit.edu	37	16	58552846	58552846	+	Silent	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr16:58552846G>A	ENST00000394266.4	+	9	1184	c.1128G>A	c.(1126-1128)gcG>gcA	p.A376A	SETD6_ENST00000219315.4_Silent_p.A445A|SETD6_ENST00000310682.2_Silent_p.A421A			Q8TBK2	SETD6_HUMAN	SET domain containing 6	445					negative regulation of NF-kappaB transcription factor activity|peptidyl-lysine monomethylation|regulation of inflammatory response	nucleus	NF-kappaB binding|protein-lysine N-methyltransferase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	7						AAGTCTATGCGAAACTCAGCT	0.443000													8	63					0	0	1	0	0
CCNB1	891	broad.mit.edu	37	5	68470094	68470094	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr5:68470094G>C	ENST00000256442.5	+	5	816	c.563G>C	c.(562-564)aGa>aCa	p.R188T		NM_031966.3	NP_114172.1	P14635	CCNB1_HUMAN	cyclin B1	188					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitotic cell cycle spindle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|mitotic spindle stabilization|positive regulation of attachment of spindle microtubules to kinetochore|positive regulation of mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	condensed nuclear chromosome outer kinetochore|cytosol|microtubule organizing center|nucleoplasm|spindle pole				large_intestine(2)|lung(5)|skin(1)	8		Lung NSC(167;5.51e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)		CAAGCAGTCAGACCAAAATAC	0.418000													10	72					0	0	1	0	0
POGK	57645	broad.mit.edu	37	1	166818925	166818925	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:166818925T>C	ENST00000367875.1	+	5	1469	c.1109T>C	c.(1108-1110)tTa>tCa	p.L370S	POGK_ENST00000367876.4_Missense_Mutation_p.L370S|POGK_ENST00000536514.1_Missense_Mutation_p.L285S|POGK_ENST00000537173.1_Missense_Mutation_p.L252S			Q9P215	POGK_HUMAN	pogo transposable element with KRAB domain	370	DDE.				multicellular organismal development|regulation of transcription, DNA-dependent	nucleus	DNA binding			endometrium(2)|kidney(1)|large_intestine(8)|lung(4)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	22						CCCATTTGTTTAGAGGTGCCA	0.517000													23	48					0	0	1	0	0
WFDC10A	140832	broad.mit.edu	37	20	44259562	44259562	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr20:44259562C>T	ENST00000372643.3	+	2	433	c.145C>T	c.(145-147)Cta>Tta	p.L49L	WFDC9_ENST00000326000.1_Intron	NM_080753.2	NP_542791.1	Q9H1F0	WF10A_HUMAN	WAP four-disulfide core domain 10A	49	WAP.					extracellular region	serine-type endopeptidase inhibitor activity			large_intestine(2)	2		Myeloproliferative disorder(115;0.0122)				TAAACTATATCTATGCAAACA	0.423000													12	61					0	0	1	0	0
CLCA1	1179	broad.mit.edu	37	1	86961305	86961305	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:86961305G>C	ENST00000234701.3	+	13	2411	c.2060G>C	c.(2059-2061)aGa>aCa	p.R687T	CLCA1_ENST00000394711.1_Missense_Mutation_p.R687T			A8K7I4	CLCA1_HUMAN	chloride channel accessory 1	687					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		GCCAGACGGAGAGTGATACCC	0.458000													10	18					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169507229	169507229	+	Silent	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr5:169507229C>G	ENST00000256935.8	+	50	5309	c.5229C>G	c.(5227-5229)ctC>ctG	p.L1743L	DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000540750.1_Silent_p.L804L|DOCK2_ENST00000520908.1_Silent_p.L1235L	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1743					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCATCCCCCTCAAGGCGTCTG	0.547000													14	26					0	0	1	0	0
NFATC2IP	84901	broad.mit.edu	37	16	28967368	28967368	+	Silent	SNP	C	C	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr16:28967368C>A	ENST00000320805.4	+	4	723	c.648C>A	c.(646-648)ctC>ctA	p.L216L	NFATC2IP_ENST00000562977.1_Intron|NFATC2IP_ENST00000564978.1_Intron	NM_032815.3	NP_116204.3	Q8NCF5	NF2IP_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein	216						cytoplasm|nucleus				breast(1)|endometrium(2)|large_intestine(1)|lung(5)|ovary(2)	11						CTCGGGCACTCAAGAAGTTAA	0.577000													22	47					8.04996e-18	8.70832e-18	1	1	0
ZC3H12A	80149	broad.mit.edu	37	1	37949105	37949105	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:37949105C>A	ENST00000373087.6	+	6	1809	c.1693C>A	c.(1693-1695)Ccc>Acc	p.P565T		NM_025079.2	NP_079355.2	Q5D1E8	ZC12A_HUMAN	zinc finger CCCH-type containing 12A	565					angiogenesis|apoptosis|cell differentiation	cytoplasm|nucleus|plasma membrane	endonuclease activity|metal ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TGGTGTGTTTCCCCCGCACCT	0.672000													17	37					9.16793e-09	9.66619e-09	1	1	0
TRANK1	9881	broad.mit.edu	37	3	36873954	36873954	+	Silent	SNP	T	T	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr3:36873954T>G	ENST00000429976.2	-	21	7235	c.6988A>C	c.(6988-6990)Agg>Cgg	p.R2330R	TRANK1_ENST00000428977.2_Silent_p.R1780R|TRANK1_ENST00000301807.6_Silent_p.R1780R	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2330					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						CCTCTCCCCCTGCCCCTTTCA	0.493000													9	76					0	0	1	0	0
BLZF1	8548	broad.mit.edu	37	1	169356242	169356242	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:169356242G>C	ENST00000367808.3	+	7	1448	c.1025G>C	c.(1024-1026)aGa>aCa	p.R342T	BLZF1_ENST00000329281.2_Missense_Mutation_p.R342T			Q9H2G9	GO45_HUMAN	basic leucine zipper nuclear factor 1	342					cell proliferation|Golgi organization|Golgi to plasma membrane protein transport|regulation of cell growth|regulation of transcription from RNA polymerase II promoter	Golgi lumen|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|prostate(1)|skin(1)	14	all_hematologic(923;0.208)					TAGGTTCTAAGAATTTTAGAT	0.328000													23	38					0	0	1	0	0
PKN2	5586	broad.mit.edu	37	1	89298481	89298481	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:89298481G>A	ENST00000370521.3	+	20	2976	c.2617G>A	c.(2617-2619)Gaa>Aaa	p.E873K	PKN2_ENST00000370505.3_Missense_Mutation_p.E716K|PKN2_ENST00000370513.5_Missense_Mutation_p.E825K|PKN2_ENST00000544045.1_Missense_Mutation_p.E547K	NM_006256.2	NP_006247.1	Q16513	PKN2_HUMAN	protein kinase N2	873	Protein kinase.				signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			breast(2)|endometrium(3)|kidney(3)|large_intestine(8)|lung(15)|prostate(1)|skin(1)	33		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		TGTAAATGATGAAGTAAGGTA	0.313000													58	102					0	0	1	0	0
SYCP1	6847	broad.mit.edu	37	1	115527399	115527399	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:115527399G>C	ENST00000369522.3	+	30	2853	c.2613G>C	c.(2611-2613)ttG>ttC	p.L871F	SYCP1_ENST00000369518.1_Missense_Mutation_p.L871F|SYCP1_ENST00000477590.1_Intron	NM_001282541.1|NM_003176.2	NP_001269470.1|NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	871					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAGAAAACTTGAATATACCCA	0.269000													45	121					0	0	1	0	0
F2RL1	2150	broad.mit.edu	37	5	76129503	76129503	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr5:76129503C>T	ENST00000296677.4	+	2	1277	c.1071C>T	c.(1069-1071)aaC>aaT	p.N357N		NM_005242.4	NP_005233	P55085	PAR2_HUMAN	coagulation factor II (thrombin) receptor-like 1	357					blood coagulation|elevation of cytosolic calcium ion concentration|positive regulation of leukocyte chemotaxis|positive regulation of positive chemotaxis|regulation of blood coagulation	Golgi apparatus|integral to plasma membrane	receptor binding|thrombin receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	13		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;7.7e-51)|Epithelial(54;2.77e-45)|all cancers(79;3.47e-41)		ATGCAAAGAACGCTCTCCTTT	0.463000													4	237					0	0	1	0	0
AGO2	27161	broad.mit.edu	37	8	141582911	141582911	+	Splice_Site	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr8:141582911C>G	ENST00000220592.5	-	3	448	c.336G>C	c.(334-336)aaG>aaC	p.K112N	AGO2_ENST00000517293.1_5'UTR|AGO2_ENST00000519980.1_Splice_Site_p.K112N	NM_012154.3	NP_036286.2			argonaute RISC catalytic component 2																		GCGAGCTTACCTTGTCCCTCC	0.488000													10	73					0	0	1	0	0
RBCK1	10616	broad.mit.edu	37	20	390551	390551	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr20:390551C>G	ENST00000356286.5	+	2	754	c.49C>G	c.(49-51)Cga>Gga	p.R17G	RBCK1_ENST00000400247.3_Intron|RBCK1_ENST00000353660.3_Intron|RBCK1_ENST00000382181.2_Intron|RBCK1_ENST00000400245.3_3'UTR|RBCK1_ENST00000475269.1_Missense_Mutation_p.R17G	NM_031229.2	NP_112506.2	Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing 1	17	Interaction with IRF3.|Interaction with TAB2.				interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|lung(4)	5		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)				GAGCCTCACCCGAGCAGTGGC	0.572000													21	176					0	0	1	0	0
GPR179	440435	broad.mit.edu	37	17	36484068	36484068	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr17:36484068C>T	ENST00000342292.4	-	11	5404	c.5384G>A	c.(5383-5385)gGc>gAc	p.G1795D	GPR179_ENST00000584976.1_Intron	NM_001004334.2	NP_001004334.2	Q6PRD1	GP179_HUMAN	G protein-coupled receptor 179	1795						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(4)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(16)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				TGGCCTGCAGCCCATATGATC	0.557000													37	85					0	0	1	0	0
CENPP	401541	broad.mit.edu	37	9	95094486	95094486	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr9:95094486G>C	ENST00000375587.3	+	2	657	c.142G>C	c.(142-144)Gaa>Caa	p.E48Q		NM_001012267.1	NP_001012267.1	Q6IPU0	CENPP_HUMAN	centromere protein P	48					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	chromosome, centromeric region|cytosol|nucleoplasm				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(1)	16						ATTCAATTTGGAAGGATGGAA	0.318000													27	18					0	0	1	0	0
RHOB	388	broad.mit.edu	37	2	20647508	20647508	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr2:20647508C>G	ENST00000272233.4	+	1	674	c.282C>G	c.(280-282)aaC>aaG	p.N94K		NM_004040.2	NP_004031.1	P62745	RHOB_HUMAN	ras homolog family member B	94					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			breast(1)|kidney(1)|lung(2)|ovary(1)|urinary_tract(2)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		CGCTGGAGAACATCCCCGAGA	0.622000													104	62					0	0	1	0	0
PEAK1	79834	broad.mit.edu	37	15	77451016	77451016	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr15:77451016C>G	ENST00000560626.2	-	5	3635	c.3160G>C	c.(3160-3162)Gag>Cag	p.E1054Q	PEAK1_ENST00000312493.4_Missense_Mutation_p.E1054Q			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	1054					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										GAAAAATCCTCTGTTACTTCA	0.433000													18	28					0	0	1	0	0
UBE2M	9040	broad.mit.edu	37	19	59067689	59067689	+	Silent	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr19:59067689G>C	ENST00000253023.3	-	5	983	c.405C>G	c.(403-405)ctC>ctG	p.L135L		NM_003969.3	NP_003960.1	P61081	UBC12_HUMAN	ubiquitin-conjugating enzyme E2M	135					protein neddylation		ATP binding|NEDD8 ligase activity|protein binding|ribosomal S6-glutamic acid ligase activity|ubiquitin-protein ligase activity			large_intestine(1)|lung(2)|ovary(1)|pancreas(1)	5		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		TCACCAAGAAGAGATACTGCA	0.547000													24	72					0	0	1	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37732580	37732580	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr8:37732580C>G	ENST00000330843.4	-	3	1087	c.1075G>C	c.(1075-1077)Gag>Cag	p.E359Q	RAB11FIP1_ENST00000524118.1_Missense_Mutation_p.E211Q|RAB11FIP1_ENST00000287263.4_Missense_Mutation_p.E359Q|RAB11FIP1_ENST00000522727.1_Missense_Mutation_p.E211Q	NM_001002814.2	NP_001002814.2	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 (class I)	359					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			GCCAGGTTCTCTGTAGAAGAG	0.567000													116	65					0	0	1	0	0
OR13J1	392309	broad.mit.edu	37	9	35870121	35870121	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr9:35870121G>C	ENST00000377981.2	-	1	340	c.278C>G	c.(277-279)tCc>tGc	p.S93C		NM_001004487.1	NP_001004487.1	Q8NGT2	O13J1_HUMAN	olfactory receptor, family 13, subfamily J, member 1	93					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|large_intestine(1)|lung(3)|skin(1)	6	all_epithelial(49;0.169)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00494)|STAD - Stomach adenocarcinoma(86;0.194)			GACAGCAAAGGAGATGGTCTT	0.587000													10	43					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155286072	155286072	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr3:155286072C>G	ENST00000460012.1	-	7	1080	c.723G>C	c.(721-723)aaG>aaC	p.K241N	PLCH1_ENST00000494598.1_Missense_Mutation_p.K259N|PLCH1_ENST00000334686.6_Missense_Mutation_p.K241N|PLCH1_ENST00000414191.1_Missense_Mutation_p.K241N|PLCH1_ENST00000340059.7_Missense_Mutation_p.K259N|PLCH1_ENST00000447496.2_Missense_Mutation_p.K259N			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	259					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CTTCAAACTTCTTTATGATGT	0.313000													18	66					0	0	1	0	0
IER2	9592	broad.mit.edu	37	19	13264165	13264165	+	Silent	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr19:13264165C>G	ENST00000588173.1	+	1	1377	c.165C>G	c.(163-165)ctC>ctG	p.L55L	CTC-250I14.6_ENST00000586483.1_RNA|CTC-250I14.6_ENST00000592882.1_RNA|IER2_ENST00000587885.1_Silent_p.L55L|IER2_ENST00000292433.3_Silent_p.L55L			Q9BTL4	IER2_HUMAN	immediate early response 2	55										kidney(1)|lung(1)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(19;3.41e-21)			TGGAGGCCCTCGAGCCCGAGG	0.731000											OREG0025291	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	6					0	0	1	0	0
CELSR2	1952	broad.mit.edu	37	1	109814054	109814054	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:109814054A>G	ENST00000271332.3	+	27	7784	c.7723A>G	c.(7723-7725)Acg>Gcg	p.T2575A	CELSR2_ENST00000498157.1_3'UTR	NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	2575					dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GCTGAGCGCCACGTGGCTGCT	0.637000													24	57					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154396605	154396605	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr5:154396605C>T	ENST00000435029.4	+	1	3346	c.3186C>T	c.(3184-3186)ggC>ggT	p.G1062G		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	1062	Globular (By similarity).|Interaction with PRC1 (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			atggtgatggcgacagtgatg	0.458000													18	22					0	0	1	0	0
POLE	5426	broad.mit.edu	37	12	133254026	133254026	+	Missense_Mutation	SNP	G	G	C	rs148525573		TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr12:133254026G>C	ENST00000320574.5	-	8	767	c.724C>G	c.(724-726)Cat>Gat	p.H242D	POLE_ENST00000535270.1_Missense_Mutation_p.H215D	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	242					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		TTGTACCAATGAGCCTGCAAA	0.438000								DNA polymerases (catalytic subunits)					10	24					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128856449	128856449	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr11:128856449C>T	ENST00000310343.9	-	13	1370	c.1371G>A	c.(1369-1371)ctG>ctA	p.L457L	ARHGAP32_ENST00000392657.3_Silent_p.L108L|ARHGAP32_ENST00000524655.1_Silent_p.L383L|ARHGAP32_ENST00000527272.1_Silent_p.L108L	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	457	Rho-GAP.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						GGTAGGTAAGCAGAGGGTTTG	0.448000													8	65					0	0	1	0	0
UBE2M	9040	broad.mit.edu	37	19	59068071	59068071	+	Silent	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr19:59068071G>C	ENST00000253023.3	-	4	908	c.330C>G	c.(328-330)gtC>gtG	p.V110V		NM_003969.3	NP_003960.1	P61081	UBC12_HUMAN	ubiquitin-conjugating enzyme E2M	110					protein neddylation		ATP binding|NEDD8 ligase activity|protein binding|ribosomal S6-glutamic acid ligase activity|ubiquitin-protein ligase activity			large_intestine(1)|lung(2)|ovary(1)|pancreas(1)	5		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		TGTTGAGGCAGACGTTGCCCT	0.587000													10	42					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168093506	168093506	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr5:168093506C>G	ENST00000519560.1	-	36	4944	c.4525G>C	c.(4525-4527)Gaa>Caa	p.E1509Q	CTC-558O2.2_ENST00000520041.1_RNA|SLIT3_ENST00000332966.8_Missense_Mutation_p.E1516Q	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	1509	CTCK.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCCACCTCTTCTACAAACGAG	0.632000													5	7					0	0	1	0	0
APOL6	80830	broad.mit.edu	37	22	36055131	36055131	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr22:36055131C>G	ENST00000409652.4	+	3	796	c.520C>G	c.(520-522)Ctt>Gtt	p.L174V		NM_030641.3	NP_085144.1	Q9BWW8	APOL6_HUMAN	apolipoprotein L, 6						lipoprotein metabolic process	cytoplasm|extracellular region	lipid binding|lipid transporter activity			haematopoietic_and_lymphoid_tissue(1)|lung(4)	5						TATCTATAATCTTAGAAACAC	0.493000													12	61					0	0	1	0	0
SERPINA12	145264	broad.mit.edu	37	14	94964231	94964231	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr14:94964231C>T	ENST00000341228.2	-	3	1299	c.504G>A	c.(502-504)caG>caA	p.Q168Q	SERPINA12_ENST00000556881.1_Silent_p.Q168Q	NM_173850.2	NP_776249.1	Q8IW75	SPA12_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12	168					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33				COAD - Colon adenocarcinoma(157;0.235)		TTTCCAAATTCTGAAAGTTGG	0.438000													47	78					0	0	1	0	0
PKD2	5311	broad.mit.edu	37	4	88987022	88987022	+	Silent	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr4:88987022G>A	ENST00000237596.2	+	12	2415	c.2349G>A	c.(2347-2349)gaG>gaA	p.E783E	PKD2_ENST00000508588.1_Silent_p.E201E|PKD2_ENST00000511337.1_3'UTR|PKD2_ENST00000502363.1_Silent_p.E201E	NM_000297.3	NP_000288.1	Q13563	PKD2_HUMAN	polycystic kidney disease 2 (autosomal dominant)	783	EF-hand domain.|EF-hand.					basal cortex|basal plasma membrane|endoplasmic reticulum|integral to membrane|lamellipodium|microtubule basal body	calcium ion binding|cytoskeletal protein binding|voltage-gated chloride channel activity|voltage-gated sodium channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(2)|lung(15)|skin(4)|upper_aerodigestive_tract(1)	36		Hepatocellular(203;0.114)|Acute lymphoblastic leukemia(40;0.221)		OV - Ovarian serous cystadenocarcinoma(123;9.98e-10)|COAD - Colon adenocarcinoma(81;0.0237)		ACGACTTGGAGAAAGAGAGGG	0.433000													23	19					0	0	1	0	0
CD46	4179	broad.mit.edu	37	1	207934593	207934593	+	Splice_Site	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:207934593G>C	ENST00000358170.2	+	5	631		c.e5-1		CD46_ENST00000322875.4_Splice_Site|CD46_ENST00000361067.1_Splice_Site|CD46_ENST00000367047.1_Splice_Site|CD46_ENST00000322918.5_Splice_Site|CD46_ENST00000367042.1_Splice_Site|CD46_ENST00000367041.1_Splice_Site|CD46_ENST00000441839.2_Splice_Site|CD46_ENST00000360212.2_Splice_Site|CD46_ENST00000480003.1_Splice_Site|CD46_ENST00000469535.1_3'UTR|CD46_ENST00000354848.1_Splice_Site|CD46_ENST00000357714.1_Splice_Site	NM_002389.4	NP_002380.3	P15529	MCP_HUMAN	CD46 molecule, complement regulatory protein						complement activation, classical pathway|innate immune response|interspecies interaction between organisms|single fertilization	inner acrosomal membrane|integral to plasma membrane	protein binding|receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(6)|prostate(1)|skin(1)	19						TCATTTTTAAGAGGTTTTGTG	0.299000													14	26					0	0	1	0	0
P2RX2	22953	broad.mit.edu	37	12	133198505	133198505	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr12:133198505G>A	ENST00000389110.3	+	11	1400	c.1363G>A	c.(1363-1365)Gag>Aag	p.E455K	P2RX2_ENST00000351222.4_Missense_Mutation_p.E363K|P2RX2_ENST00000348800.5_Missense_Mutation_p.E388K|P2RX2_ENST00000343948.4_Missense_Mutation_p.E481K|P2RX2_ENST00000449132.2_Missense_Mutation_p.E354K|P2RX2_ENST00000352418.4_Missense_Mutation_p.E383K|P2RX2_ENST00000350048.5_Missense_Mutation_p.E431K	NM_170682.2|NM_170683.2|NM_174873.1	NP_733782.1|NP_733783.1|NP_777362.1	Q9UBL9	P2RX2_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 2	455					positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling|protein homooligomerization	integral to membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity			NS(1)|breast(1)|kidney(2)|large_intestine(2)|liver(2)|lung(8)|ovary(1)|prostate(3)	20	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0767)		OV - Ovarian serous cystadenocarcinoma(86;2.32e-08)|Epithelial(86;8.62e-08)|all cancers(50;4.5e-06)		TCCTGCCTCCGAGCCTGCCCA	0.652000													8	53					0	0	1	0	0
CELF3	11189	broad.mit.edu	37	1	151677544	151677544	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:151677544C>T	ENST00000290583.4	-	12	2164	c.1371G>A	c.(1369-1371)cgG>cgA	p.R457R	CELF3_ENST00000470688.1_5'UTR|CELF3_ENST00000392706.3_Silent_p.R252R|RP11-98D18.1_ENST00000457548.1_RNA|CELF3_ENST00000290585.4_Silent_p.R407R	NM_001172648.1|NM_007185.4	NP_001166119.1|NP_009116.3	Q5SZQ8	CELF3_HUMAN	CUGBP, Elav-like family member 3	457	RRM 3.				nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	mRNA binding|nucleotide binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)	21						CATCCTTAGGCCGCTTTAGCT	0.627000													3	51					0	0	1	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20527419	20527419	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr20:20527419G>A	ENST00000202677.7	-	24	3221	c.3214C>T	c.(3214-3216)Cct>Tct	p.P1072S		NM_020343.3	NP_065076.2	Q2PPJ7	RGPA2_HUMAN	Ral GTPase activating protein, alpha subunit 2 (catalytic)						activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	54						GAGAAGCCAGGAAAACCCAGG	0.473000													4	46					0	0	1	0	0
AKR1E2	83592	broad.mit.edu	37	10	4879744	4879744	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr10:4879744G>A	ENST00000298375.7	+	5	624	c.553G>A	c.(553-555)Ggg>Agg	p.G185R	AKR1E2_ENST00000334019.4_Missense_Mutation_p.G185R|AKR1E2_ENST00000345253.5_Intron|AKR1E2_ENST00000525281.1_3'UTR|AKR1E2_ENST00000532248.1_Missense_Mutation_p.G185R	NM_001040177.2	NP_001035267.1	Q96JD6	AKCL2_HUMAN	aldo-keto reductase family 1, member E2	185						cytoplasm	1,5-anhydro-D-fructose reductase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)	15						GAATAAGCCTGGGTTGAGGTT	0.537000													21	39					0	0	1	0	0
NVL	4931	broad.mit.edu	37	1	224488310	224488310	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:224488310G>A	ENST00000281701.6	-	10	1275	c.1016C>T	c.(1015-1017)tCc>tTc	p.S339F	NVL_ENST00000482491.1_Missense_Mutation_p.S63F|NVL_ENST00000361463.3_Missense_Mutation_p.S233F|NVL_ENST00000340871.4_Missense_Mutation_p.S150F|NVL_ENST00000469075.1_Missense_Mutation_p.S248F|NVL_ENST00000391875.2_Missense_Mutation_p.S233F	NM_002533.3	NP_002524.2	O15381	NVL_HUMAN	nuclear VCP-like	339						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(13)|ovary(1)|prostate(1)|skin(4)|soft_tissue(1)|urinary_tract(1)	42				GBM - Glioblastoma multiforme(131;0.00501)		AGACTCTCCGGATACTCCAGA	0.408000													15	19					0	0	1	0	0
RPL19	6143	broad.mit.edu	37	17	37360850	37360850	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr17:37360850G>C	ENST00000579260.1	+	6	937	c.534G>C	c.(532-534)aaG>aaC	p.K178N	RPL19_ENST00000582193.1_Missense_Mutation_p.K178N|RPL19_ENST00000225430.4_Missense_Mutation_p.K180N|RPL19_ENST00000579374.1_Missense_Mutation_p.K177N			P84098	RL19_HUMAN	ribosomal protein L19	180					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|structural constituent of ribosome			kidney(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	7						TCCAGGCCAAGAAGGAGGAGA	0.512000													22	62					0	0	1	0	0
NUB1	51667	broad.mit.edu	37	7	151049920	151049920	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr7:151049920C>G	ENST00000568733.1	+	5	505	c.439C>G	c.(439-441)Caa>Gaa	p.Q147E	NUB1_ENST00000355851.4_Missense_Mutation_p.Q123E|NUB1_ENST00000413040.2_Missense_Mutation_p.Q147E|NUB1_ENST00000477666.1_3'UTR|NUB1_ENST00000566856.1_Missense_Mutation_p.Q123E			Q9Y5A7	NUB1_HUMAN	negative regulator of ubiquitin-like proteins 1	123					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|response to interferon-gamma|response to tumor necrosis factor|ubiquitin-dependent protein catabolic process	nucleus	protein binding			endometrium(1)|large_intestine(7)|lung(3)	11			OV - Ovarian serous cystadenocarcinoma(82;0.00569)	UCEC - Uterine corpus endometrioid carcinoma (81;0.172)		CTTTGGACTTCAAGAAAATTA	0.279000													15	39					0	0	1	0	0
SERPINA12	145264	broad.mit.edu	37	14	94964360	94964360	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr14:94964360C>T	ENST00000341228.2	-	3	1170	c.375G>A	c.(373-375)caG>caA	p.Q125Q	SERPINA12_ENST00000556881.1_Silent_p.Q125Q	NM_173850.2	NP_776249.1	Q8IW75	SPA12_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12	125					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity	p.Q125H(1)		breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33				COAD - Colon adenocarcinoma(157;0.235)		CCTGGGTCTTCTGGGTCAGCT	0.488000													39	105					0	0	1	0	0
PLXND1	23129	broad.mit.edu	37	3	129278515	129278515	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr3:129278515C>T	ENST00000393239.1	-	32	5423	c.5245G>A	c.(5245-5247)Gag>Aag	p.E1749K	PLXND1_ENST00000324093.4_Missense_Mutation_p.E1749K			Q9Y4D7	PLXD1_HUMAN	plexin D1	1749					axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						CCCCTCTTCTCAGCCTGCTCC	0.582000													47	62					0	0	1	0	0
CNST	163882	broad.mit.edu	37	1	246797230	246797230	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:246797230G>C	ENST00000366513.4	+	5	890	c.621G>C	c.(619-621)gaG>gaC	p.E207D	CNST_ENST00000483271.1_3'UTR|CNST_ENST00000366512.3_Missense_Mutation_p.E207D	NM_152609.2	NP_689822.2	Q6PJW8	CNST_HUMAN	consortin, connexin sorting protein	207					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|urinary_tract(2)	28						ATTCAGATGAGAAAGCAATGA	0.348000													29	91					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189931480	189931480	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr2:189931480C>G	ENST00000374866.3	-	22	1704	c.1430G>C	c.(1429-1431)gGa>gCa	p.G477A		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	477					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			GCCAGCTTCTCCTTTGAAACC	0.378000													58	52					0	0	1	0	0
PARD3	56288	broad.mit.edu	37	10	34620087	34620087	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr10:34620087C>T	ENST00000374789.3	-	19	3125	c.2800G>A	c.(2800-2802)Gat>Aat	p.D934N	PARD3_ENST00000346874.4_Missense_Mutation_p.D934N|PARD3_ENST00000350537.4_Missense_Mutation_p.D888N|PARD3_ENST00000545260.1_Missense_Mutation_p.D844N|PARD3_ENST00000374773.1_Missense_Mutation_p.D901N|PARD3_ENST00000340077.5_Missense_Mutation_p.D931N|PARD3_ENST00000466092.1_5'UTR|PARD3_ENST00000374790.3_Missense_Mutation_p.D874N|PARD3_ENST00000544292.1_Missense_Mutation_p.D647N|PARD3_ENST00000545693.1_Missense_Mutation_p.D918N|PARD3_ENST00000374788.3_Missense_Mutation_p.D931N|PARD3_ENST00000374794.3_Missense_Mutation_p.D859N|PARD3_ENST00000374776.1_Missense_Mutation_p.D888N	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	934	Interacts with PRKCZ (By similarity).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				GCGGGTTTATCATAAGATTTG	0.418000													30	53					0	0	1	0	0
KIDINS220	57498	broad.mit.edu	37	2	8877078	8877078	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr2:8877078C>A	ENST00000256707.3	-	27	3818	c.3637G>T	c.(3637-3639)Gat>Tat	p.D1213Y	KIDINS220_ENST00000473731.1_Missense_Mutation_p.D1194Y|KIDINS220_ENST00000418530.1_Missense_Mutation_p.D1114Y|KIDINS220_ENST00000427284.1_Missense_Mutation_p.D1194Y	NM_020738.2	NP_065789.1	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate, 220kDa	1213					activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(25)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	60	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CATACTGCATCCACATTCAGT	0.458000													33	19					8.16721e-17	8.80244e-17	1	1	0
MADD	8567	broad.mit.edu	37	11	47330578	47330578	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr11:47330578G>C	ENST00000311027.5	+	26	4081	c.3916G>C	c.(3916-3918)Gag>Cag	p.E1306Q	MADD_ENST00000407859.3_Intron|MADD_ENST00000406482.1_Intron|MADD_ENST00000405573.2_Missense_Mutation_p.E116Q|MADD_ENST00000349238.3_Intron|MADD_ENST00000395336.3_Missense_Mutation_p.E1306Q|MADD_ENST00000395344.3_Intron|MADD_ENST00000402799.1_Intron|MADD_ENST00000342922.4_Intron|MADD_ENST00000402192.2_Intron	NM_003682.3	NP_003673.3	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain	1306					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			breast(7)|central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(19)|lung(26)|ovary(6)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	84				Lung(87;0.182)		TGCAGCTATGGAGACCTTTTC	0.498000													49	34					0	0	1	0	0
TRIM28	10155	broad.mit.edu	37	19	59059181	59059181	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr19:59059181C>T	ENST00000253024.5	+	6	1151	c.862C>T	c.(862-864)Cag>Tag	p.Q288*	TRIM28_ENST00000341753.6_Nonsense_Mutation_p.Q206*	NM_005762.2	NP_005753.1	Q13263	TIF1B_HUMAN	tripartite motif containing 28	288	Leucine zipper alpha helical coiled-coil region.|RBCC domain.				epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent	nucleoplasm	chromo shadow domain binding|ligase activity|transcription corepressor activity|zinc ion binding			biliary_tract(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|urinary_tract(1)	19		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		GTCTGACGTACAGAAGCGTGT	0.582000													15	72					0	0	1	0	0
KCNH3	23416	broad.mit.edu	37	12	49951250	49951250	+	Silent	SNP	G	G	A	rs140591831		TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr12:49951250G>A	ENST00000257981.6	+	15	3026	c.2766G>A	c.(2764-2766)tcG>tcA	p.S922S		NM_012284.1	NP_036416.1	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 3	922					regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36						CTCGGGCATCGGGAGAGGGGC	0.682000													7	12					0	0	1	0	0
RPL15	6138	broad.mit.edu	37	3	23959442	23959442	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr3:23959442G>T	ENST00000307839.5	+	2	731	c.92G>T	c.(91-93)cGc>cTc	p.R31L	RPL15_ENST00000456530.2_Missense_Mutation_p.R31L|RPL15_ENST00000435882.1_Missense_Mutation_p.R31L|RPL15_ENST00000413699.1_Missense_Mutation_p.R31L|NKIRAS1_ENST00000421515.2_Intron|RPL15_ENST00000415719.1_Missense_Mutation_p.R31L|RPL15_ENST00000354811.5_Missense_Mutation_p.R31L	NM_001253379.1|NM_001253380.1|NM_002948.3	NP_001240308.1|NP_001240309.1|NP_002939.2	P61313	RL15_HUMAN	ribosomal protein L15	31					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)	7						TGGCAGTACCGCCAGCTCTCT	0.587000													17	26					5.3912e-06	5.603e-06	1	1	0
OR5I1	10798	broad.mit.edu	37	11	55703277	55703277	+	Silent	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr11:55703277G>C	ENST00000301532.3	-	1	599	c.600C>G	c.(598-600)ctC>ctG	p.L200L		NM_006637.1	NP_006628.1	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I, member 1	200					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(34)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						ATGTGGAGAGGAGCCACTCAT	0.378000													12	6					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28966700	28966700	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr18:28966700G>C	ENST00000359747.4	+	3	163	c.134G>C	c.(133-135)aGa>aCa	p.R45T	RP11-534N16.1_ENST00000581856.1_RNA|DSG4_ENST00000308128.4_Missense_Mutation_p.R45T|RP11-534N16.1_ENST00000578477.1_RNA|RP11-534N16.1_ENST00000581452.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	45					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CAAACAGTCAGAAGACAAAAG	0.428000													34	38					0	0	1	0	0
C20orf194	25943	broad.mit.edu	37	20	3362059	3362059	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr20:3362059C>G	ENST00000252032.9	-	3	317	c.250G>C	c.(250-252)Gag>Cag	p.E84Q		NM_001009984.2	NP_001009984.1	Q5TEA3	CT194_HUMAN	chromosome 20 open reading frame 194	84										NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	39						CCCGTTTTCTCAAAATCACTG	0.363000													16	75					0	0	1	0	0
ZMYND8	23613	broad.mit.edu	37	20	45874931	45874931	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr20:45874931G>C	ENST00000311275.7	-	14	2298	c.2045C>G	c.(2044-2046)tCa>tGa	p.S682*	ZMYND8_ENST00000446994.2_Nonsense_Mutation_p.S619*|ZMYND8_ENST00000372023.3_Nonsense_Mutation_p.S677*|ZMYND8_ENST00000471951.2_Nonsense_Mutation_p.S702*|ZMYND8_ENST00000468376.2_5'UTR|ZMYND8_ENST00000355972.4_Nonsense_Mutation_p.S682*|ZMYND8_ENST00000540497.1_Nonsense_Mutation_p.S630*|ZMYND8_ENST00000262975.4_Nonsense_Mutation_p.S682*|ZMYND8_ENST00000536340.1_Nonsense_Mutation_p.S709*|ZMYND8_ENST00000396281.4_Nonsense_Mutation_p.S682*|ZMYND8_ENST00000360911.3_Nonsense_Mutation_p.S677*|ZMYND8_ENST00000461685.1_Nonsense_Mutation_p.S702*|ZMYND8_ENST00000352431.2_Nonsense_Mutation_p.S702*|ZMYND8_ENST00000458360.2_Nonsense_Mutation_p.S677*	NM_001281772.1|NM_001281778.1|NM_001281783.1	NP_001268701.1|NP_001268707.1|NP_001268712.1	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8	682							protein binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|prostate(3)|skin(2)|urinary_tract(8)	62			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			GGGGTGAGGTGAAGGTTTTGC	0.512000													96	110					0	0	1	0	0
RNF40	9810	broad.mit.edu	37	16	30779568	30779568	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr16:30779568C>G	ENST00000324685.6	+	13	2131	c.1696C>G	c.(1696-1698)Cca>Gca	p.P566A	RNF40_ENST00000563683.1_Missense_Mutation_p.P526A|RNF40_ENST00000357890.5_Missense_Mutation_p.P466A|RNF40_ENST00000402121.3_Missense_Mutation_p.P258A	NM_001207033.1|NM_014771.3	NP_001193962.1|NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40, E3 ubiquitin protein ligase	566					histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)	30			Colorectal(24;0.198)			GGAGATGGCTCCAGTGCCTGG	0.632000													10	33					0	0	1	0	0
TRIM37	4591	broad.mit.edu	37	17	57148277	57148277	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr17:57148277G>C	ENST00000376149.3	-	9	1159	c.350C>G	c.(349-351)tCt>tGt	p.S117C	TRIM37_ENST00000262294.7_Missense_Mutation_p.S239C|TRIM37_ENST00000393065.2_Missense_Mutation_p.S205C|TRIM37_ENST00000393066.3_Missense_Mutation_p.S239C			O94972	TRI37_HUMAN	tripartite motif containing 37	239						perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(13)|ovary(1)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					TGAGCTCTTAGATATCAACTC	0.393000									Mulibrey Nanism				27	50					0	0	1	0	0
CCNB1	891	broad.mit.edu	37	5	68470222	68470222	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr5:68470222G>C	ENST00000256442.5	+	5	944	c.691G>C	c.(691-693)Gat>Cat	p.D231H		NM_031966.3	NP_114172.1	P14635	CCNB1_HUMAN	cyclin B1	231					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitotic cell cycle spindle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|mitotic spindle stabilization|positive regulation of attachment of spindle microtubules to kinetochore|positive regulation of mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	condensed nuclear chromosome outer kinetochore|cytosol|microtubule organizing center|nucleoplasm|spindle pole				large_intestine(2)|lung(5)|skin(1)	8		Lung NSC(167;5.51e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)		CTCCATTATTGATCGGTTCAT	0.453000													25	118					0	0	1	0	0
KCNJ2	3759	broad.mit.edu	37	17	68172185	68172185	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr17:68172185C>A	ENST00000243457.3	+	2	1388	c.1005C>A	c.(1003-1005)caC>caA	p.H335Q	KCNJ2_ENST00000535240.1_Missense_Mutation_p.H335Q	NM_000891.2	NP_000882.1	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 2	335					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(13)|skin(1)|urinary_tract(1)	25	Breast(10;1.64e-08)					AAGAGAAGCACTACTACAAAG	0.473000													17	79					1.15088e-07	1.2047e-07	1	1	0
OR2M3	127062	broad.mit.edu	37	1	248367151	248367151	+	Missense_Mutation	SNP	G	G	A	rs145845024		TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:248367151G>A	ENST00000456743.1	+	1	820	c.782G>A	c.(781-783)cGg>cAg	p.R261Q		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	261					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ATGTACATACGGCCCACATCT	0.502000													75	166					0	0	1	0	0
GMEB2	26205	broad.mit.edu	37	20	62221629	62221629	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr20:62221629A>G	ENST00000266068.1	-	9	1884	c.1406T>C	c.(1405-1407)tTc>tCc	p.F469S	GMEB2_ENST00000370077.1_Missense_Mutation_p.F469S|GMEB2_ENST00000370069.1_Missense_Mutation_p.F418S			Q9UKD1	GMEB2_HUMAN	glucocorticoid modulatory element binding protein 2	469					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|metal ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)	18	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;4.79e-09)|all cancers(9;2.76e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.0114)			GACCACCTTGAACACCGTGCT	0.667000													10	46					0	0	1	0	0
OR8B2	26595	broad.mit.edu	37	11	124252742	124252742	+	Silent	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr11:124252742G>C	ENST00000375013.2	-	1	516	c.498C>G	c.(496-498)ctC>ctG	p.L166L		NM_001005468.1	NP_001005468.1	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B, member 2	166					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(13)|ovary(1)	23		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		TGCAGAAGGTGAGTCTAAGCA	0.512000													6	39					0	0	1	0	0
FBF1	85302	broad.mit.edu	37	17	73921519	73921519	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr17:73921519C>A	ENST00000586717.1	-	12	1108	c.835G>T	c.(835-837)Gat>Tat	p.D279Y	FBF1_ENST00000319129.5_Missense_Mutation_p.D279Y|FBF1_ENST00000389570.4_Missense_Mutation_p.D279Y			A6NLR5	A6NLR5_HUMAN	Fas (TNFRSF6) binding factor 1	279										large_intestine(2)|ovary(1)|upper_aerodigestive_tract(1)	4						CCCCACATATCTTCACTGTCT	0.532000													13	11					2.31682e-05	2.38232e-05	1	1	0
CXorf58	254158	broad.mit.edu	37	X	23957400	23957400	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chrX:23957400C>T	ENST00000379211.3	+	9	1528	c.979C>T	c.(979-981)Cat>Tat	p.H327Y		NM_001169574.1|NM_152761.2	NP_001163045.1|NP_689974.2	Q96LI9	CX058_HUMAN	chromosome X open reading frame 58	327										breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(2)|prostate(1)	14						GGATAACTATCATCTCCACTC	0.343000													13	13					0	0	1	0	0
CD81-AS1	101927682	broad.mit.edu	37	11	2356815	2356815	+	RNA	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr11:2356815G>A	ENST00000413483.1	-	0	407				RPL26P30_ENST00000602923.1_RNA																							GAACTACCTGGACCTCGTCGT	0.537000													67	50					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94574170	94574170	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:94574170G>T	ENST00000370225.3	-	4	491	c.405C>A	c.(403-405)ttC>ttA	p.F135L	ABCA4_ENST00000535735.1_Missense_Mutation_p.F135L	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	135					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GGGTGTCCATGAATTGGGACA	0.488000													24	44					4.4004e-07	4.58967e-07	1	1	0
EGF	1950	broad.mit.edu	37	4	110883036	110883036	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr4:110883036C>T	ENST00000265171.5	+	8	1652	c.1207C>T	c.(1207-1209)Cgc>Tgc	p.R403C	EGF_ENST00000503392.1_Missense_Mutation_p.R403C|EGF_ENST00000509793.1_Missense_Mutation_p.R361C	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	403	EGF-like 3.				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	TTCCTGTCCACGCAATGTGTC	0.403000													7	100					0	0	1	0	0
NIN	51199	broad.mit.edu	37	14	51225017	51225017	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr14:51225017C>T	ENST00000245441.5	-	18	2921	c.2731G>A	c.(2731-2733)Gag>Aag	p.E911K	NIN_ENST00000324330.9_Missense_Mutation_p.E911K|NIN_ENST00000453196.1_Missense_Mutation_p.E911K|NIN_ENST00000530997.2_Missense_Mutation_p.E911K|NIN_ENST00000389868.3_Intron|NIN_ENST00000382041.3_Missense_Mutation_p.E911K|NIN_ENST00000382043.4_Intron	NM_020921.3	NP_065972	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	911					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					TGCTGTCTCTCGACGACCATG	0.463000			T	PDGFRB	MPD								31	77					0	0	1	0	0
ZNF225	7768	broad.mit.edu	37	19	44635715	44635715	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr19:44635715C>G	ENST00000262894.6	+	5	1228	c.948C>G	c.(946-948)ttC>ttG	p.F316L	ZNF225_ENST00000590612.1_Missense_Mutation_p.F316L|ZNF225_ENST00000592780.1_3'UTR	NM_013362.2	NP_037494.2	Q9UK10	ZN225_HUMAN	zinc finger protein 225	316					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|skin(1)|stomach(1)	16		Prostate(69;0.0352)|all_neural(266;0.202)				AGAAACCATTCAGATGTGATA	0.423000													47	127					0	0	1	0	0
ATP2B1	490	broad.mit.edu	37	12	90013955	90013955	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr12:90013955C>T	ENST00000428670.3	-	11	2106	c.1650G>A	c.(1648-1650)ttG>ttA	p.L550L	ATP2B1_ENST00000359142.3_Silent_p.L550L|ATP2B1_ENST00000393164.2_Silent_p.L293L|ATP2B1_ENST00000261173.2_Silent_p.L550L|ATP2B1_ENST00000348959.3_Silent_p.L550L			P20020	AT2B1_HUMAN	ATPase, Ca++ transporting, plasma membrane 1	550					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	45						AAAGAAGTCCCAACAAGGCAC	0.378000													12	41					0	0	1	0	0
ANAPC1	64682	broad.mit.edu	37	2	112608394	112608394	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr2:112608394T>C	ENST00000341068.3	-	14	2381	c.1609A>G	c.(1609-1611)Act>Gct	p.T537A		NM_022662.3	NP_073153.1	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	537					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm		p.T537A(5)		NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(7)|lung(16)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	49						GGCTTTGGAGTACTAACGCCA	0.433000													4	77					0	0	1	0	0
A2ML1	144568	broad.mit.edu	37	12	9009896	9009896	+	Silent	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr12:9009896G>A	ENST00000299698.7	+	24	3165	c.2985G>A	c.(2983-2985)acG>acA	p.T995T	A2ML1_ENST00000539547.1_Silent_p.T504T	NM_001282424.1|NM_144670.4	NP_001269353.1|NP_653271	B3KVV6	B3KVV6_HUMAN	alpha-2-macroglobulin-like 1	839						extracellular space	endopeptidase inhibitor activity			NS(2)|breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(2)|lung(36)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	80						GGCTGCTGACGGAGGAGATCA	0.522000													14	69					0	0	1	0	0
OGFR	11054	broad.mit.edu	37	20	61444836	61444836	+	Silent	SNP	C	C	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr20:61444836C>A	ENST00000370461.1	+	5	3990	c.1713C>A	c.(1711-1713)ggC>ggA	p.G571G	OGFR_ENST00000290291.6_Silent_p.G623G			Q9NZT2	OGFR_HUMAN	opioid growth factor receptor	623	7 X 20 AA approximate tandem repeats of [ST]-P-S-E-T-P-G-P-[SR]-P-A-G-P-[AT]- [GR]-D-E-P-A-[EK].				regulation of cell growth	cytoplasm|membrane|nucleus	opioid receptor activity			endometrium(2)|kidney(1)|lung(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	17	Breast(26;3.65e-08)					AGACCCCAGGCCCCCGCCCGG	0.731000													3	39					0.115264	0.115661	1	1	0
KIAA1199	57214	broad.mit.edu	37	15	81229024	81229024	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr15:81229024C>G	ENST00000394685.3	+	24	3438	c.3019C>G	c.(3019-3021)Caa>Gaa	p.Q1007E	KIAA1199_ENST00000220244.3_Missense_Mutation_p.Q1007E|RP11-351M8.2_ENST00000560873.1_RNA|KIAA1199_ENST00000356249.5_Missense_Mutation_p.Q1007E			Q8WUJ3	K1199_HUMAN	KIAA1199	1007										breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						GATGTACATTCAAGCCTACAA	0.463000													37	84					0	0	1	0	0
LNX1	84708	broad.mit.edu	37	4	54374302	54374302	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr4:54374302G>A	ENST00000306888.2	-	2	436	c.185C>T	c.(184-186)aCg>aTg	p.T62M	LNX1-AS1_ENST00000514364.1_RNA|LNX1-AS1_ENST00000511989.1_RNA|LNX1-AS1_ENST00000510785.1_RNA|LNX1_ENST00000263925.7_Missense_Mutation_p.T158M|FIP1L1_ENST00000507166.1_Intron	NM_032622.2	NP_116011.2	Q8TBB1	LNX1_HUMAN	ligand of numb-protein X 1, E3 ubiquitin protein ligase	158						cytoplasm	zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|endometrium(3)|large_intestine(11)|lung(6)|ovary(3)|urinary_tract(4)	32	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			GGAGGGAGCCGTGGCTGTGAG	0.597000													6	18					0	0	1	0	0
ALYREF	10189	broad.mit.edu	37	17	79846175	79846175	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr17:79846175G>A	ENST00000331204.4	-	5	727	c.701C>T	c.(700-702)tCa>tTa	p.S234L	ALYREF_ENST00000505490.2_Missense_Mutation_p.S241L	NM_005782.3	NP_005773.3	Q86V81	THOC4_HUMAN	Aly/REF export factor	234					intronless viral mRNA export from host nucleus|mRNA 3'-end processing|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear speck|transcription export complex	nucleotide binding|protein binding|RNA binding										CTGCTGCTTTGAATTCCTGCC	0.652000													14	16					0	0	1	0	0
SFMBT2	57713	broad.mit.edu	37	10	7239623	7239623	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr10:7239623G>A	ENST00000361972.4	-	15	1675	c.1585C>T	c.(1585-1587)Cct>Tct	p.P529S	SFMBT2_ENST00000397167.1_Missense_Mutation_p.P529S	NM_001018039.1	NP_001018049.1	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	529					regulation of transcription, DNA-dependent	nucleus				NS(2)|breast(3)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(26)|lung(34)|ovary(5)|pancreas(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	99						AAGAGCTGAGGACAGCAGTAT	0.557000													29	48					0	0	1	0	0
PLXND1	23129	broad.mit.edu	37	3	129278615	129278615	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr3:129278615C>A	ENST00000393239.1	-	32	5323	c.5145G>T	c.(5143-5145)caG>caT	p.Q1715H	PLXND1_ENST00000324093.4_Missense_Mutation_p.Q1715H			Q9Y4D7	PLXD1_HUMAN	plexin D1	1715					axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						CCAGAAACTTCTGCAACGTGC	0.607000													36	62					5.8336e-16	6.26413e-16	1	1	0
CENPI	2491	broad.mit.edu	37	X	100402946	100402946	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chrX:100402946C>T	ENST00000372927.1	+	19	2167	c.1890C>T	c.(1888-1890)ttC>ttT	p.F630F	CENPI_ENST00000218507.5_Silent_p.F630F|CENPI_ENST00000423383.1_Silent_p.F630F	NM_006733.2	NP_006724.2	Q92674	CENPI_HUMAN	centromere protein I	630					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(19)|prostate(1)|skin(2)	30						AATCAGAGTTCAATTTCAGCA	0.353000													13	17					0	0	1	0	0
TBC1D12	23232	broad.mit.edu	37	10	96162370	96162370	+	Translation_Start_Site	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr10:96162370G>A	ENST00000225235.4	+	0	110					NM_015188.1	NP_056003.1	O60347	TBC12_HUMAN	TBC1 domain family, member 12							intracellular	Rab GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	20		Colorectal(252;0.0429)				CCCACCCCCAGATGGTGGGTC	0.697000													11	5					0	0	1	0	0
C1GALT1	56913	broad.mit.edu	37	7	7278163	7278163	+	Silent	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr7:7278163G>A	ENST00000436587.2	+	3	721	c.498G>A	c.(496-498)ttG>ttA	p.L166L	C1GALT1_ENST00000402468.3_Silent_p.L166L|C1GALT1_ENST00000223122.3_Silent_p.L166L	NM_020156.3	NP_064541.1	Q9NS00	C1GLT_HUMAN	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1	166					angiogenesis|cell differentiation|kidney development	integral to membrane	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity|metal ion binding			breast(1)|kidney(1)|lung(3)|prostate(1)|urinary_tract(1)	7				UCEC - Uterine corpus endometrioid carcinoma (126;0.177)		ATTGGTTTTTGAAAGCAGATG	0.358000													31	47					0	0	1	0	0
NUP98	4928	broad.mit.edu	37	11	3800411	3800411	+	Silent	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr11:3800411G>C	ENST00000324932.7	-	3	573	c.153C>G	c.(151-153)ctC>ctG	p.L51L	NUP98_ENST00000359171.4_Silent_p.L51L|NUP98_ENST00000355260.3_Silent_p.L51L|NUP98_ENST00000397007.4_Silent_p.L51L|NUP98_ENST00000397004.4_Silent_p.L51L	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	51	Gly/Thr-rich.				carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		AATTTCCAAAGAGGCCTCCAG	0.408000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								90	82					0	0	1	0	0
GSC2	2928	broad.mit.edu	37	22	19136519	19136519	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr22:19136519C>T	ENST00000086933.2	-	3	602	c.603G>A	c.(601-603)ccG>ccA	p.P201P		NM_005315.1	NP_005306.1	O15499	GSC2_HUMAN	goosecoid homeobox 2	201					anatomical structure morphogenesis|regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(1)|lung(2)	4	Colorectal(54;0.0993)					AGCTCCCCTTCGGGGACTTCT	0.627000													4	8					0	0	1	0	0
MIEF1	54471	broad.mit.edu	37	22	39908024	39908024	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr22:39908024C>T	ENST00000325301.2	+	4	739	c.315C>T	c.(313-315)ttC>ttT	p.F105F	MIEF1_ENST00000404569.1_Silent_p.F105F|MIEF1_ENST00000402881.1_Silent_p.F105F	NM_019008.4	NP_061881.2			mitochondrial elongation factor 1	105																	CCTCCACCTTCGACACAGGTG	0.592000													15	56					0	0	1	0	0
RGP1	9827	broad.mit.edu	37	9	35749850	35749850	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr9:35749850C>T	ENST00000378078.4	+	2	239	c.98C>T	c.(97-99)aCg>aTg	p.T33M	RGP1_ENST00000456972.2_Missense_Mutation_p.T73M|GBA2_ENST00000545786.1_De_novo_Start_InFrame	NM_001080496.2	NP_001073965.2	Q92546	RGP1_HUMAN	RGP1 retrograde golgi transport homolog (S. cerevisiae)	33										cervix(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	14	all_epithelial(49;0.167)		Lung(28;0.00416)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CTTCCGCCCACGGCCACTTCT	0.597000													13	44					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114284532	114284532	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr4:114284532C>G	ENST00000357077.4	+	40	10848	c.10795C>G	c.(10795-10797)Cat>Gat	p.H3599D	ANK2_ENST00000506722.1_Missense_Mutation_p.H1505D|ANK2_ENST00000394537.3_Missense_Mutation_p.H1514D|ANK2_ENST00000264366.6_Missense_Mutation_p.H3566D|ANK2_ENST00000509550.1_Missense_Mutation_p.H690D|ANK2_ENST00000510275.2_Missense_Mutation_p.H166D	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	3566	Death.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GGAGCAAATTCATCAAATTCG	0.378000													15	17					0	0	1	0	0
TIGD7	91151	broad.mit.edu	37	16	3349202	3349202	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr16:3349202C>G	ENST00000396862.1	-	2	3241	c.1413G>C	c.(1411-1413)caG>caC	p.Q471H	TIGD7_ENST00000268674.2_Missense_Mutation_p.Q471H	NM_033208.3	NP_149985.2	Q6NT04	TIGD7_HUMAN	tigger transposable element derived 7	471					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	12						ATTCAGCAGTCTGCTTCTCAG	0.408000													45	114					0	0	1	0	0
LINC00969	440993	broad.mit.edu	37	3	195400728	195400728	+	RNA	SNP	A	A	G	rs12107841	by1000genomes	TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr3:195400728A>G	ENST00000445430.1	+	0	1324																											GATTGTGCCCAGCCTGTACGC	0.587000													7	28					0	0	1	0	0
DPY19L2P1	554236	broad.mit.edu	37	7	35131548	35131548	+	RNA	SNP	G	G	A	rs144021252	by1000genomes	TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr7:35131548G>A	ENST00000436258.1	-	0	1821																											TGGCACCTGCGAAGACAGCAT	0.388000													3	64					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71054112	71054112	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr16:71054112C>G	ENST00000393567.2	-	22	3445	c.3295G>C	c.(3295-3297)Gag>Cag	p.E1099Q	HYDIN_ENST00000448089.2_Missense_Mutation_p.E1051Q	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	1099								p.E1051Q(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TTATCAGTCTCACATATAAAG	0.507000													7	14					0	0	1	0	0
CRYBA4	1413	broad.mit.edu	37	22	27024278	27024278	+	Silent	SNP	C	C	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr22:27024278C>A	ENST00000354760.3	+	5	362	c.327C>A	c.(325-327)atC>atA	p.I109I	CRYBA4_ENST00000466315.1_3'UTR	NM_001886.2	NP_001877.1	P53673	CRBA4_HUMAN	crystallin, beta A4	109	Beta/gamma crystallin 'Greek key' 3.				camera-type eye development|visual perception	soluble fraction	structural constituent of eye lens	p.I109I(1)		large_intestine(6)|liver(1)|lung(6)|skin(3)|urinary_tract(2)	18						GGCTGACAATCTTCGAGCAAG	0.562000													20	59					4.35082e-09	4.60395e-09	1	1	0
PLEKHG5	57449	broad.mit.edu	37	1	6533126	6533126	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:6533126C>G	ENST00000377748.1	-	10	1632	c.1135G>C	c.(1135-1137)Gag>Cag	p.E379Q	PLEKHG5_ENST00000377740.3_Missense_Mutation_p.E379Q|PLEKHG5_ENST00000377732.1_Missense_Mutation_p.E339Q|PLEKHG5_ENST00000400913.1_Missense_Mutation_p.E302Q|PLEKHG5_ENST00000400915.3_Missense_Mutation_p.E358Q|PLEKHG5_ENST00000544978.1_Missense_Mutation_p.E302Q|PLEKHG5_ENST00000377737.2_Missense_Mutation_p.E302Q|PLEKHG5_ENST00000377728.3_Missense_Mutation_p.E302Q|PLEKHG5_ENST00000377725.1_Missense_Mutation_p.E302Q|PLEKHG5_ENST00000537245.1_Missense_Mutation_p.E381Q|PLEKHG5_ENST00000535355.1_Missense_Mutation_p.E371Q|PLEKHG5_ENST00000340850.5_Missense_Mutation_p.E302Q	NM_198681.3	NP_941374.2	O94827	PKHG5_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 5	358					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		TCATCGTACTCCTCCTCCCAG	0.637000													6	35					0	0	1	0	0
TBC1D20	128637	broad.mit.edu	37	20	422261	422261	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr20:422261C>T	ENST00000354200.4	-	5	744	c.597G>A	c.(595-597)gtG>gtA	p.V199V	TBC1D20_ENST00000461188.1_5'UTR	NM_144628.2	NP_653229.1	Q96BZ9	TBC20_HUMAN	TBC1 domain family, member 20	199	Rab-GAP TBC.				interspecies interaction between organisms	integral to membrane|intracellular	Rab GTPase activator activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	12		all_epithelial(17;0.228)|Breast(17;0.231)				GCTCTGGATTCACCTGGTCAA	0.468000													28	110					0	0	1	0	0
ESYT2	57488	broad.mit.edu	37	7	158526939	158526939	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr7:158526939C>G	ENST00000251527.5	-	22	2706	c.2641G>C	c.(2641-2643)Gac>Cac	p.D881H	ESYT2_ENST00000435514.2_Missense_Mutation_p.D316H	NM_020728.2	NP_065779.1	A0FGR8	ESYT2_HUMAN	extended synaptotagmin-like protein 2	909	C2 3.					integral to membrane|plasma membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(16)|prostate(2)	32						TCCGTGAGGTCATACCTGAGA	0.572000													8	17					0	0	1	0	0
LIPE	3991	broad.mit.edu	37	19	42911874	42911874	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr19:42911874C>G	ENST00000244289.4	-	5	2002	c.1726G>C	c.(1726-1728)Gag>Cag	p.E576Q	LIPE-AS1_ENST00000599276.1_RNA|LIPE_ENST00000602000.1_5'UTR|LIPE-AS1_ENST00000593491.2_RNA|LIPE-AS1_ENST00000594624.2_RNA|LIPE-AS1_ENST00000597203.1_RNA	NM_005357.2	NP_005348.2	Q05469	LIPS_HUMAN	lipase, hormone-sensitive	576					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			breast(2)|endometrium(4)|kidney(7)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		Prostate(69;0.00682)				AGTGGCATCTCAAAGGCTTCG	0.652000													16	40					0	0	1	0	0
SLC9A9	285195	broad.mit.edu	37	3	143100929	143100929	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr3:143100929C>T	ENST00000316549.6	-	13	1705	c.1497G>A	c.(1495-1497)ctG>ctA	p.L499L	SLC9A9-AS2_ENST00000490153.1_RNA	NM_173653.3	NP_775924.1	Q8IVB4	SL9A9_HUMAN	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9	499					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(13)|lung(29)|ovary(2)|skin(3)|stomach(1)	57						GGTCCTCCTTCAGATTTTCAT	0.443000													49	104					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157514817	157514817	+	Silent	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:157514817C>G	ENST00000361835.3	-	4	520	c.363G>C	c.(361-363)ctG>ctC	p.L121L	FCRL5_ENST00000368189.3_Silent_p.L121L|FCRL5_ENST00000368191.3_Silent_p.L36L|FCRL5_ENST00000368190.3_Silent_p.L121L|FCRL5_ENST00000356953.4_Silent_p.L121L	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	121						integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				CCCGGCACCTCAGAACCACAG	0.413000													35	40					0	0	1	0	0
TMC4	147798	broad.mit.edu	37	19	54666423	54666423	+	Silent	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr19:54666423G>A	ENST00000376591.4	-	10	1634	c.1503C>T	c.(1501-1503)ctC>ctT	p.L501L	TMC4_ENST00000301187.4_Silent_p.L495L|TMC4_ENST00000416963.1_Silent_p.L83L	NM_001145303.1|NM_144686.2	NP_001138775|NP_653287.2	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4	501						integral to membrane				breast(2)|endometrium(7)|large_intestine(4)|lung(6)|pancreas(1)|skin(1)|urinary_tract(1)	22	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GAAACTGGATGAGCAGCGCGA	0.567000													9	22					0	0	1	0	0
BNC2	54796	broad.mit.edu	37	9	16727871	16727871	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr9:16727871G>A	ENST00000380672.4	-	3	311	c.254C>T	c.(253-255)aCg>aTg	p.T85M	BNC2_ENST00000545497.1_Intron|BNC2_ENST00000380666.2_Missense_Mutation_p.T85M|BNC2_ENST00000380667.2_Intron	NM_017637.5	NP_060107.3	Q6ZN30	BNC2_HUMAN	basonuclin 2	85					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(16)|liver(1)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(50;9.01e-08)		AGCCGTAGTCGTTCTGGTTCC	0.453000													22	165					0	0	1	0	0
RGS7	6000	broad.mit.edu	37	1	241099949	241099949	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:241099949G>C	ENST00000366565.1	-	5	665	c.284C>G	c.(283-285)tCa>tGa	p.S95*	RGS7_ENST00000366563.1_Nonsense_Mutation_p.S95*|RGS7_ENST00000366564.1_Nonsense_Mutation_p.S95*|RGS7_ENST00000446183.2_Nonsense_Mutation_p.S11*|RGS7_ENST00000407727.1_Nonsense_Mutation_p.S95*|RGS7_ENST00000331110.7_Nonsense_Mutation_p.S69*|RGS7_ENST00000401882.1_Intron|RGS7_ENST00000366562.4_Nonsense_Mutation_p.S95*|RGS7_ENST00000348120.2_Intron	NM_002924.4	NP_002915.3	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	95	DEP.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(51)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			GACATGATCTGAGATTGGAAA	0.393000													20	65					0	0	1	0	0
TRNT1	51095	broad.mit.edu	37	3	3186363	3186363	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr3:3186363G>C	ENST00000251607.6	+	5	679	c.577G>C	c.(577-579)Gag>Cag	p.E193Q	TRNT1_ENST00000280591.6_Missense_Mutation_p.E193Q	NM_182916.2	NP_886552	Q96Q11	TRNT1_HUMAN	tRNA nucleotidyl transferase, CCA-adding, 1	193					protein targeting to mitochondrion|tRNA 3'-end processing	mitochondrion	ATP binding|tRNA adenylyltransferase activity|tRNA binding			breast(2)|endometrium(3)|large_intestine(4)|lung(2)|urinary_tract(1)	12				Epithelial(13;0.00226)|OV - Ovarian serous cystadenocarcinoma(96;0.00592)|all cancers(10;0.011)		GAGAATACAAGAGGATTATCT	0.264000													25	28					0	0	1	0	0
CNST	163882	broad.mit.edu	37	1	246811353	246811353	+	Nonstop_Mutation	SNP	G	G	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:246811353G>T	ENST00000366512.3	+	9	2230	c.1850G>T	c.(1849-1851)tGa>tTa	p.*617L	CNST_ENST00000483271.1_3'UTR|CNST_ENST00000366513.4_Intron	NM_001139459.1	NP_001132931.1	Q6PJW8	CNST_HUMAN	consortin, connexin sorting protein	0					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|urinary_tract(2)	28						AATCAGAGATGAAGTACAATT	0.343000													19	58					2.35188e-11	2.50695e-11	1	1	0
CES2	8824	broad.mit.edu	37	16	66969516	66969516	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr16:66969516G>A	ENST00000317091.4	+	1	1154	c.170G>A	c.(169-171)cGa>cAa	p.R57Q	CES2_ENST00000417689.1_Missense_Mutation_p.R57Q	NM_003869.5	NP_003860.2	O00748	EST2_HUMAN	carboxylesterase 2	0					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(1)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|prostate(1)|urinary_tract(1)	12		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		CGCCGGCAGCGAACCGAGACC	0.677000													38	88					0	0	1	0	0
VAT1	10493	broad.mit.edu	37	17	41169886	41169886	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr17:41169886C>T	ENST00000355653.3	-	4	923	c.828G>A	c.(826-828)ctG>ctA	p.L276L	VAT1_ENST00000587173.1_Silent_p.L208L|VAT1_ENST00000420567.3_Silent_p.L142L	NM_006373.3	NP_006364.2	Q99536	VAT1_HUMAN	vesicle amine transport 1	276						cytoplasm|integral to membrane	oxidoreductase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(2)|upper_aerodigestive_tract(1)	9		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.156)		CCATGGGTTTCAGGAGGTTGT	0.537000													24	38					0	0	1	0	0
CELA2A	63036	broad.mit.edu	37	1	15788083	15788083	+	Missense_Mutation	SNP	A	A	C	rs150024502		TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:15788083A>C	ENST00000359621.4	+	3	182	c.157A>C	c.(157-159)Aag>Cag	p.K53Q		NM_033440.2	NP_254275.1	P08217	CEL2A_HUMAN	chymotrypsin-like elastase family, member 2A	53	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|ovary(2)|prostate(1)	16						CTCCAATGGCAAGTGGTACCA	0.597000													26	59					0	0	1	0	0
TMX4	56255	broad.mit.edu	37	20	7962981	7962981	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr20:7962981C>T	ENST00000246024.2	-	8	1182	c.967G>A	c.(967-969)Gag>Aag	p.E323K		NM_021156.2	NP_066979.2	Q9H1E5	TMX4_HUMAN	thioredoxin-related transmembrane protein 4	323	Glu-rich.				cell redox homeostasis|electron transport chain|transport	integral to membrane				endometrium(3)|large_intestine(2)|lung(11)|skin(1)	17						CAGGGTTGCTCAGAGATGCCT	0.552000													12	72					0	0	1	0	0
TSN	7247	broad.mit.edu	37	2	122520583	122520583	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr2:122520583G>C	ENST00000389682.3	+	5	623	c.376G>C	c.(376-378)Gag>Cag	p.E126Q	TSN_ENST00000409193.1_Missense_Mutation_p.E121Q|TSN_ENST00000536142.1_Intron|TSN_ENST00000498545.1_3'UTR	NM_001261401.1|NM_004622.2	NP_001248330.1|NP_004613.1	Q15631	TSN_HUMAN	translin	126					DNA recombination	cytoplasm|nucleus	sequence-specific DNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|large_intestine(1)|liver(1)|lung(3)|skin(1)	12		Ovarian(717;0.0563)|Prostate(154;0.116)				TTTTTTAGTTGAGCCAGATCG	0.363000													8	34					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11187803	11187803	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:11187803C>T	ENST00000361445.4	-	44	6170	c.6094G>A	c.(6094-6096)Gaa>Aaa	p.E2032K	MTOR_ENST00000376838.1_Missense_Mutation_p.E237K	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	2032					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						GATGCCTCTTCCAGGCCTTCA	0.537000													65	152					0	0	1	0	0
KNOP1	400506	broad.mit.edu	37	16	19725472	19725472	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr16:19725472C>T	ENST00000219837.7	-	2	964	c.886G>A	c.(886-888)Gag>Aag	p.E296K	AC002550.5_ENST00000565916.1_RNA	NM_001012991.2	NP_001013009.2			lysine-rich nucleolar protein 1																		ACCCCACTCTCTTTCCTCTTC	0.483000													32	158					0	0	1	0	0
C2CD2L	9854	broad.mit.edu	37	11	118983417	118983417	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr11:118983417A>G	ENST00000336702.3	+	10	1579	c.1220A>G	c.(1219-1221)tAt>tGt	p.Y407C	C2CD2L_ENST00000528586.1_Missense_Mutation_p.Y155C	NM_014807.3	NP_055622.3	O14523	C2C2L_HUMAN	C2CD2-like	407						integral to membrane				NS(1)|endometrium(1)|large_intestine(2)|lung(8)|prostate(1)	13						CAGCTTCACTATGAGGAGGGC	0.612000													19	17					0	0	1	0	0
NUFIP1	26747	broad.mit.edu	37	13	45523860	45523860	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr13:45523860C>G	ENST00000379161.4	-	8	1181	c.1135G>C	c.(1135-1137)Gaa>Caa	p.E379Q		NM_012345.2	NP_036477.2	Q9UHK0	NUFP1_HUMAN	nuclear fragile X mental retardation protein interacting protein 1	379					box C/D snoRNP assembly|positive regulation of transcription from RNA polymerase II promoter|RNA processing	actin cytoskeleton|cytosolic ribosome|nuclear matrix|nucleolus|perichromatin fibrils|pre-snoRNP complex|presynaptic active zone|transcription elongation factor complex	DNA binding|identical protein binding|protein binding, bridging|RNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(4)|skin(3)	18		Lung NSC(96;8.23e-05)|Breast(139;0.00378)|Prostate(109;0.0107)|all_hematologic(4;0.014)|Lung SC(185;0.0262)|Hepatocellular(98;0.0524)|Acute lymphoblastic leukemia(4;0.143)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000306)|BRCA - Breast invasive adenocarcinoma(63;0.125)		GACTTACCTTCTGGCTCACTC	0.448000													22	42					0	0	1	0	0
KLRAP1	10748	broad.mit.edu	37	12	10749545	10749545	+	RNA	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr12:10749545G>A	ENST00000510134.2	-	0	315																				breast(1)|large_intestine(1)|lung(1)	3						AGGATCCCAAGAGTCACTGCA	0.408000													8	21					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577559	7577559	+	Missense_Mutation	SNP	G	G	A	rs28934573		TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr17:7577559G>A	ENST00000420246.2	-	7	854	c.722C>T	c.(721-723)tCc>tTc	p.S241F	TP53_ENST00000359597.4_Missense_Mutation_p.S241F|TP53_ENST00000455263.2_Missense_Mutation_p.S241F|TP53_ENST00000445888.2_Missense_Mutation_p.S241F|TP53_ENST00000269305.4_Missense_Mutation_p.S241F|TP53_ENST00000413465.2_Missense_Mutation_p.S241F	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	241	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		S -> A (in sporadic cancers; somatic mutation).|S -> C (in sporadic cancers; somatic mutation).|S -> F (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934573).|S -> P (in sporadic cancers; somatic mutation).|S -> T (in LFS; germline mutation and in sporadic cancers; somatic mutation).|S -> Y (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.S241F(85)|p.S241C(26)|p.0?(8)|p.S241Y(8)|p.C242fs*5(6)|p.?(5)|p.S241del(5)|p.S148F(4)|p.N239_C242delNSSC(3)|p.N239_C242>S(1)|p.C238fs*21(1)|p.S241fs*22(1)|p.N239_C242del(1)|p.Y236_M243delYMCNSSCM(1)|p.S241_G245delSCMGG(1)|p.S148C(1)|p.N239fs*4(1)|p.C238_M246delCNSSCMGGM(1)|p.H233_C242del10(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCCCATGCAGGAACTGTTACA	0.572000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			10	17					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113256737	113256737	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr8:113256737G>C	ENST00000297405.5	-	65	10532	c.10288C>G	c.(10288-10290)Cat>Gat	p.H3430D	CSMD3_ENST00000455883.2_Missense_Mutation_p.H3261D|CSMD3_ENST00000343508.3_Missense_Mutation_p.H3390D|CSMD3_ENST00000352409.3_Missense_Mutation_p.H3360D	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3430	Sushi 28.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GTATACCCATGAGATGGAAGG	0.423000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			40	41					0	0	1	0	0
XPR1	9213	broad.mit.edu	37	1	180775644	180775644	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:180775644G>A	ENST00000367590.4	+	6	830	c.632G>A	c.(631-633)aGa>aAa	p.R211K	XPR1_ENST00000367589.3_Missense_Mutation_p.R211K	NM_004736.3	NP_004727.2	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor 1	211						integral to plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	35						GATGGTGACAGACAAAAGGCT	0.373000													10	72					0	0	1	0	0
ZNF528	84436	broad.mit.edu	37	19	52919984	52919984	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr19:52919984C>T	ENST00000360465.3	+	7	2305	c.1879C>T	c.(1879-1881)Cat>Tat	p.H627Y	ZNF528_ENST00000391788.2_3'UTR	NM_032423.2	NP_115799.2	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	627					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(6)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	39				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		TCAGAGAGTTCATTCATGAGA	0.393000													8	36					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23869930	23869930	+	Silent	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr14:23869930G>A	ENST00000405093.3	-	13	1468	c.1398C>T	c.(1396-1398)ttC>ttT	p.F466F	MYH6_ENST00000356287.3_Silent_p.F466F	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	466	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CGAAGATCTCGAAGCCAGCGA	0.552000													14	24					0	0	1	0	0
KTN1	3895	broad.mit.edu	37	14	56079156	56079156	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr14:56079156C>G	ENST00000416613.1	+	1	462	c.390C>G	c.(388-390)atC>atG	p.I130M	KTN1_ENST00000395311.1_Missense_Mutation_p.I130M|KTN1_ENST00000438792.2_Missense_Mutation_p.I130M|KTN1_ENST00000395308.1_Missense_Mutation_p.I130M|KTN1_ENST00000395309.3_Missense_Mutation_p.I130M|KTN1_ENST00000413890.2_Missense_Mutation_p.I130M|KTN1_ENST00000395314.3_Missense_Mutation_p.I130M			Q86UP2	KTN1_HUMAN	kinectin 1 (kinesin receptor)	130					microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(4)|central_nervous_system(1)|large_intestine(8)|lung(1)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	19						AGCAGGTCATCAAAGAAAGTG	0.438000			T	RET	papillary thryoid								22	68					0	0	1	0	0
RRM2B	50484	broad.mit.edu	37	8	103238200	103238200	+	Silent	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr8:103238200G>A	ENST00000251810.3	-	3	510	c.267C>T	c.(265-267)atC>atT	p.I89I	RRM2B_ENST00000519317.1_Intron|RRM2B_ENST00000519962.1_Intron|RRM2B_ENST00000395912.2_Silent_p.I37I	NM_001172478.1|NM_015713.4	NP_001165949.1|NP_056528.2	Q7LG56	RIR2B_HUMAN	ribonucleotide reductase M2 B (TP53 inducible)	89					deoxyribonucleoside diphosphate metabolic process|DNA repair|nucleobase, nucleoside and nucleotide interconversion	nucleoplasm	ribonucleoside-diphosphate reductase activity|transition metal ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	9	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000728)			AGATGTGAGAGATGAAGTACT	0.333000								Modulation of nucleotide pools					11	54					0	0	1	0	0
ITPR3	3710	broad.mit.edu	37	6	33659476	33659476	+	Missense_Mutation	SNP	C	C	T	rs139781035		TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr6:33659476C>T	ENST00000374316.5	+	54	8370	c.7310C>T	c.(7309-7311)tCg>tTg	p.S2437L	ITPR3_ENST00000605930.1_Missense_Mutation_p.S2437L			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	2437					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						TCAGGGCTCTCGGTGCCTGAG	0.627000													32	22					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39453083	39453083	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr13:39453083G>C	ENST00000280481.7	+	23	9191	c.8975G>C	c.(8974-8976)gGa>gCa	p.G2992A		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2992					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GGATCTGATGGATTTAAAGTC	0.423000													22	68					0	0	1	0	0
TMEM98	26022	broad.mit.edu	37	17	31263409	31263409	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr17:31263409G>C	ENST00000579849.1	+	6	788	c.357G>C	c.(355-357)atG>atC	p.M119I	TMEM98_ENST00000578289.1_Missense_Mutation_p.M119I|TMEM98_ENST00000394642.3_Missense_Mutation_p.M119I	NM_015544.2	NP_056359.2	Q9Y2Y6	TMM98_HUMAN	transmembrane protein 98	119						endoplasmic reticulum|integral to membrane				kidney(2)|large_intestine(1)	3		Ovarian(249;0.182)|Breast(31;0.244)	BRCA - Breast invasive adenocarcinoma(9;0.0769)			GGGCCAAGATGAAGACTTCAG	0.567000													26	37					0	0	1	0	0
DLG2	1740	broad.mit.edu	37	11	83810001	83810001	+	Silent	SNP	T	T	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr11:83810001T>A	ENST00000398309.2	-	5	869	c.399A>T	c.(397-399)atA>atT	p.I133I	DLG2_ENST00000376106.3_5'UTR|DLG2_ENST00000418306.2_Silent_p.I82I|DLG2_ENST00000398301.2_Silent_p.I172I|DLG2_ENST00000376104.2_Silent_p.I238I|DLG2_ENST00000280241.8_Silent_p.I172I|DLG2_ENST00000531015.1_Silent_p.I100I|DLG2_ENST00000330014.6_Silent_p.I72I|DLG2_ENST00000532653.1_Silent_p.I133I|DLG2_ENST00000537455.1_5'UTR|DLG2_ENST00000524982.1_Silent_p.I133I|DLG2_ENST00000543673.1_Silent_p.I238I	NM_001364.3	NP_001355.2	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	133	PDZ 1.					cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				CACCTCCTGGTATAATCTTCG	0.428000													7	34					0	0	1	0	0
LGR4	55366	broad.mit.edu	37	11	27389579	27389579	+	Silent	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr11:27389579G>A	ENST00000379214.4	-	18	3134	c.2691C>T	c.(2689-2691)tcC>tcT	p.S897S	LGR4_ENST00000389858.4_Silent_p.S873S	NM_018490.2	NP_060960.2	Q9BXB1	LGR4_HUMAN	leucine-rich repeat containing G protein-coupled receptor 4	897						integral to membrane|plasma membrane	protein-hormone receptor activity			NS(3)|breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(10)|ovary(1)	32						TGCCACAGTCGGACCAGTAGC	0.498000													20	52					0	0	1	0	0
PMS2CL	441194	broad.mit.edu	37	7	6777016	6777016	+	RNA	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr7:6777016C>T	ENST00000486256.1	+	0	1143					NR_002217.1																						AGTGACCCTACGGACAGAGCG	0.582000													13	69					0	0	1	0	0
GNE	10020	broad.mit.edu	37	9	36217391	36217391	+	Silent	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr9:36217391G>A	ENST00000396594.3	-	12	2344	c.2233C>T	c.(2233-2235)Ctg>Ttg	p.L745L	GNE_ENST00000539815.1_Silent_p.L714L|GNE_ENST00000377902.5_Silent_p.L714L|GNE_ENST00000447283.2_Silent_p.L640L|GNE_ENST00000543356.2_Silent_p.L709L|GNE_ENST00000539208.1_Silent_p.L604L	NM_001128227.2	NP_001121699.1	Q9Y223	GLCNE_HUMAN	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	714					cell adhesion|lipopolysaccharide biosynthetic process|N-acetylneuraminate metabolic process|UDP-N-acetylglucosamine metabolic process		ATP binding|N-acylmannosamine kinase activity|UDP-N-acetylglucosamine 2-epimerase activity			endometrium(8)|kidney(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			STAD - Stomach adenocarcinoma(86;0.228)			GTGTAGTCCAGAACCATGCTG	0.547000													3	28					0	0	1	0	0
SYT17	51760	broad.mit.edu	37	16	19278221	19278221	+	Silent	SNP	G	G	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr16:19278221G>A	ENST00000562034.1	+	6	4863	c.1065G>A	c.(1063-1065)aaG>aaA	p.K355K	SYT17_ENST00000355377.2_Silent_p.K416K|SYT17_ENST00000568433.1_Silent_p.K110K|SYT17_ENST00000562711.2_Silent_p.K412K			Q9BSW7	SYT17_HUMAN	synaptotagmin XVII	416	C2 2.					membrane|synaptic vesicle	transporter activity			NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	17						ACAACATGAAGAGCAGCAATG	0.572000													16	14					0	0	1	0	0
CLIC6	54102	broad.mit.edu	37	21	36079615	36079615	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr21:36079615T>A	ENST00000360731.3	+	3	1466	c.1466T>A	c.(1465-1467)tTt>tAt	p.F489Y	CLIC6_ENST00000349499.2_Missense_Mutation_p.F471Y			Q96NY7	CLIC6_HUMAN	chloride intracellular channel 6	489						chloride channel complex|cytoplasm|plasma membrane	voltage-gated chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	19						AATTGCCCGTTTTCTCAGCGT	0.438000													12	47					0	0	1	0	0
RRBP1	6238	broad.mit.edu	37	20	17640924	17640924	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr20:17640924C>G	ENST00000377813.1	-	3	532	c.229G>C	c.(229-231)Gag>Cag	p.E77Q	RRBP1_ENST00000246043.4_Missense_Mutation_p.E77Q|RRBP1_ENST00000360807.4_Missense_Mutation_p.E77Q|RRBP1_ENST00000377807.2_Missense_Mutation_p.E77Q|RRBP1_ENST00000455029.2_Intron			Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	77					protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(6)	28						TTAGGTttctcttcctttttc	0.498000													4	16					0	0	1	0	0
U2AF2	11338	broad.mit.edu	37	19	56179916	56179916	+	Silent	SNP	C	C	T			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr19:56179916C>T	ENST00000450554.2	+	8	1745	c.786C>T	c.(784-786)ttC>ttT	p.F262F	U2AF2_ENST00000590551.1_Silent_p.F98F|CTD-2537I9.12_ENST00000589456.1_RNA|CTD-2537I9.12_ENST00000585940.1_RNA|U2AF2_ENST00000308924.4_Silent_p.F262F	NM_001012478.1|NM_007279.2	NP_001012496.1|NP_009210.1	P26368	U2AF2_HUMAN	U2 small nuclear RNA auxiliary factor 2	262	RRM 2.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	nucleoplasm|spliceosomal complex	enzyme binding|nucleotide binding|RNA binding			biliary_tract(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|urinary_tract(2)	21		Colorectal(82;0.00244)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		ACAAGCTGTTCATCGGGGGCT	0.582000													11	17					0	0	1	0	0
TPR	7175	broad.mit.edu	37	1	186295316	186295316	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr1:186295316delT	ENST00000367478.4	-	41	6237	c.5941delA	c.(5941-5943)atgfs	p.M1981fs		NM_003292.2	NP_003283.2	P12270	TPR_HUMAN	translocated promoter region, nuclear basket protein						carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			autonomic_ganglia(1)|breast(5)|central_nervous_system(4)|cervix(2)|endometrium(9)|kidney(12)|large_intestine(23)|liver(1)|lung(45)|ovary(2)|pancreas(1)|prostate(6)|skin(3)|stomach(1)|urinary_tract(8)	123		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		tcatcTCCCATCCCTGTGtca	0.413			T	NTRK1	papillary thyroid								13	26	---	---	---	---					
ADH1C	126	broad.mit.edu	37	4	100268235	100268237	+	RNA	DEL	GAA	GAA	-			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr4:100268235_100268237delGAA	ENST00000515683.1	-	0	536_538				ADH1C_ENST00000510055.1_RNA	NM_000669.3	NP_000660.1	P00326	ADH1G_HUMAN	alcohol dehydrogenase 1C (class I), gamma polypeptide						ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding								OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	AAAATCACAGGAAGGGGGGTCAC	0.483													53	46	---	---	---	---					
PTCD1	26024	broad.mit.edu	37	7	99017661	99017661	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr7:99017661delG	ENST00000292478.4	-	8	2282	c.2032delC	c.(2032-2034)cggfs	p.R678fs	ATP5J2-PTCD1_ENST00000413834.1_Frame_Shift_Del_p.R727fs|PTCD1_ENST00000555673.1_Frame_Shift_Del_p.R727fs	NM_015545.3	NP_056360.2			pentatricopeptide repeat domain 1											endometrium(5)|large_intestine(3)|lung(16)|ovary(2)|skin(1)	27	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			GGCTTGGTCCGGAACTTCTGC	0.612													51	101	---	---	---	---					
VSIG2	23584	broad.mit.edu	37	11	124620739	124620740	+	Frame_Shift_Ins	INS	-	-	G			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr11:124620739_124620740insG	ENST00000403470.1	-	3	352_353	c.297_298insC	c.(295-300)cccacafs	p.T100fs	VSIG2_ENST00000326621.5_Frame_Shift_Ins_p.T100fs			Q96IQ7	VSIG2_HUMAN	V-set and immunoglobulin domain containing 2	100	Ig-like V-type.					integral to plasma membrane|membrane fraction				central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(5)	19	all_hematologic(175;0.215)	Breast(109;0.00663)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0215)		ACCCCCACTGTGGGGGGGTTCT	0.540													11	53	---	---	---	---					
CHST14	113189	broad.mit.edu	37	15	40763679	40763686	+	Frame_Shift_Del	DEL	GCCTGGGG	GCCTGGGG	-			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr15:40763679_40763686delGCCTGGGG	ENST00000306243.5	+	1	520_527	c.267_274delGCCTGGGG	c.(265-276)aagcctgggggcfs	p.PGG90fs	CHST14_ENST00000559991.1_Frame_Shift_Del_p.PGG90fs	NM_130468.3	NP_569735.1	Q8NCH0	CHSTE_HUMAN	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14	90					carbohydrate biosynthetic process|dermatan sulfate proteoglycan metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity|phosphate binding			cervix(1)|large_intestine(1)|prostate(2)	4		all_cancers(109;2.34e-14)|all_epithelial(112;1.08e-11)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0781)		AAGCCCCCAAGCCTGGGGGCCTGTCCCT	0.726													4	9	---	---	---	---					
ITGAL	3683	broad.mit.edu	37	16	30531249	30531251	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr16:30531249_30531251delGCT	ENST00000356798.6	+	30	3480_3482	c.3300_3302delGCT	c.(3298-3303)gggctg>ggg	p.L1106del	ITGAL_ENST00000433423.2_In_Frame_Del_p.L340del|ITGAL_ENST00000358164.5_In_Frame_Del_p.L1022del	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	1106					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	GCATCGGGGGGCTGCTGCTGCTG	0.601													7	205	---	---	---	---					
MED13	9969	broad.mit.edu	37	17	60033782	60033783	+	In_Frame_Ins	INS	-	-	CAC			TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr17:60033782_60033783insCAC	ENST00000397786.2	-	24	5616_5617	c.5540_5541insGTG	c.(5539-5541)tgc>tgGTGc	p.1846_1847insW		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1846					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						CAAGTCCTAAGCACCACTCCCA	0.366													15	131	---	---	---	---					
CYP4F8	11283	broad.mit.edu	37	19	15730745	15730747	+	RNA	DEL	TAA	TAA	-	rs140849245		TCGA-ZF-A9R0-01A-11D-A38G-08	TCGA-ZF-A9R0-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	51ebb569-a35e-4f72-8bcd-000d05ca9603	2e7d1891-7bf8-4459-979f-9ffa36579f3c	g.chr19:15730745_15730747delTAA	ENST00000441682.2	+	0	586							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						taggagcatgtaatggactcatg	0.468													3	3	---	---	---	---					
