Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZFC3H1	196441	broad.mit.edu	37	12	72030288	72030288	+	Silent	SNP	A	A	G			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr12:72030288A>G	ENST00000378743.3	-	9	2440	c.2082T>C	c.(2080-2082)ctT>ctC	p.L694L		NM_144982.4	NP_659419.3	O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	694					RNA processing	intracellular	metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						CAGTTCGTGGAAGACGGGGTC	0.373000													23	41					0	0	1	0	0
DDX10	1662	broad.mit.edu	37	11	108593995	108593995	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr11:108593995G>C	ENST00000526794.1	+	13	1803	c.1771G>C	c.(1771-1773)Gaa>Caa	p.E591Q	DDX10_ENST00000322536.3_Missense_Mutation_p.E591Q			Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	591							ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(11)|pancreas(1)|prostate(2)	27		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		cgatgaagaagaaATGGAAGA	0.428000			T	NUP98	AML*								9	8					0	0	1	0	0
ZNF821	55565	broad.mit.edu	37	16	71894426	71894426	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr16:71894426C>T	ENST00000425432.1	-	8	1113	c.734G>A	c.(733-735)cGt>cAt	p.R245H	ZNF821_ENST00000446827.2_Missense_Mutation_p.R203H|ATXN1L_ENST00000569119.1_Intron|ZNF821_ENST00000564134.1_3'UTR|ZNF821_ENST00000565601.1_Missense_Mutation_p.R245H|ZNF821_ENST00000313565.6_Missense_Mutation_p.R203H	NM_001201552.1	NP_001188481.1	O75541	ZN821_HUMAN	zinc finger protein 821	245					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|ovary(2)	13						CAGCAGTTTACGGTAGGCAGC	0.557000													4	69					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32868660	32868660	+	Silent	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr13:32868660G>A	ENST00000380250.3	+	60	9232	c.8736G>A	c.(8734-8736)ctG>ctA	p.L2912L	FRY_ENST00000542859.1_Silent_p.L282L|FRY_ENST00000380217.1_Silent_p.L94L	NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2912					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TGGAGTGCCTGAAGAACAACG	0.547000													19	22					0	0	1	0	0
AVPR2	554	broad.mit.edu	37	X	153172088	153172088	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chrX:153172088G>T	ENST00000358927.2	+	4	1231	c.1022G>T	c.(1021-1023)tGc>tTc	p.C341F	AVPR2_ENST00000337474.5_Missense_Mutation_p.C341F|AVPR2_ENST00000370049.1_3'UTR			P30518	V2R_HUMAN	arginine vasopressin receptor 2	341					activation of adenylate cyclase activity|excretion|G-protein signaling, coupled to cAMP nucleotide second messenger|hemostasis|positive regulation of gene expression|transmembrane transport|water transport	endoplasmic reticulum|endosome|Golgi apparatus|integral to plasma membrane	vasopressin receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	26	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Conivaptan(DB00872)|Terlipressin(DB02638)|Vasopressin(DB00067)	AGCTTGCTCTGCTGTGCCCGG	0.617000													12	64					0.00010058	0.000101331	1	1	0
KANK2	25959	broad.mit.edu	37	19	11285369	11285369	+	Splice_Site	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr19:11285369C>T	ENST00000432929.2	-	9	2233		c.e9-1		KANK2_ENST00000355150.5_Splice_Site|KANK2_ENST00000586659.1_Splice_Site|KANK2_ENST00000589359.1_Splice_Site|KANK2_ENST00000589894.1_Splice_Site	NM_001136191.2	NP_001129663.1	Q63ZY3	KANK2_HUMAN	KN motif and ankyrin repeat domains 2											endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						AGGCCACTTTCTGCATGCGAG	0.697000													3	8					0	0	1	0	0
WNT11	7481	broad.mit.edu	37	11	75907584	75907584	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr11:75907584G>A	ENST00000322563.3	-	2	386	c.262C>T	c.(262-264)Cgc>Tgc	p.R88C		NM_004626.2	NP_004617.2	O96014	WNT11_HUMAN	wingless-type MMTV integration site family, member 11	88					adrenal gland development|anterior/posterior pattern formation|artery morphogenesis|axis specification|bone mineralization|cellular response to retinoic acid|cloacal septation|embryonic skeletal system development|endoderm development|lung-associated mesenchyme development|mesonephric duct development|negative regulation of apoptosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell migration|negative regulation of transcription, DNA-dependent|neuroendocrine cell differentiation|neuron differentiation|osteoblast differentiation|outflow tract morphogenesis|palate development|positive regulation of cell migration|positive regulation of protein kinase C signaling cascade|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor-beta2 production|protein localization at cell surface|protein phosphorylation|tight junction assembly|ureteric bud morphogenesis|ventricular septum morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|protein kinase activator activity|Ras GTPase activator activity|transcription regulatory region DNA binding			breast(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	20						CAGTTCCAGCGCATGTCGGCA	0.632000													4	70					0	0	1	0	0
MALAT1	378938	broad.mit.edu	37	11	65267658	65267658	+	RNA	SNP	T	T	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr11:65267658T>A	ENST00000534336.1	+	0	2426					NR_002819.2																						TGGTGTAATTTAAAAAAAACT	0.343000													4	8					0	0	1	0	0
KIAA1598	57698	broad.mit.edu	37	10	118713581	118713581	+	Silent	SNP	G	G	C			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr10:118713581G>C	ENST00000355371.4	-	5	905	c.408C>G	c.(406-408)gtC>gtG	p.V136V	KIAA1598_ENST00000260777.10_Silent_p.V136V|KIAA1598_ENST00000392903.2_Silent_p.V136V|KIAA1598_ENST00000392901.4_Silent_p.V76V|KIAA1598_ENST00000497044.1_5'UTR	NM_001127211.2|NM_001258298.1|NM_001258299.1	NP_001120683.1|NP_001245227.1|NP_001245228.1	A0MZ66	SHOT1_HUMAN	KIAA1598	136					axon guidance	axon				endometrium(1)|kidney(1)|large_intestine(5)|lung(3)	10				all cancers(201;0.00494)		ACTGTACTGAGACACAAGTCT	0.418000													38	28					0	0	1	0	0
MIR329-1	574408	broad.mit.edu	37	14	101493161	101493161	+	RNA	SNP	A	A	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr14:101493161A>T	ENST00000385028.1	+	0	40					NR_029967.1																						TGTTTCTTTAATGAGGACGAA	0.468000													4	146					0	0	1	0	0
AGTR2	186	broad.mit.edu	37	X	115304054	115304054	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chrX:115304054C>T	ENST00000371906.4	+	3	711	c.521C>T	c.(520-522)tCc>tTc	p.S174F		NM_000686.4	NP_000677.2	P50052	AGTR2_HUMAN	angiotensin II receptor, type 2	174					behavior|blood vessel remodeling|brain development|G-protein signaling, coupled to cGMP nucleotide second messenger|intracellular protein kinase cascade|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of heart rate|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of nitric-oxide synthase activity|positive regulation of phosphoprotein phosphatase activity|positive regulation of vasodilation|regulation of systemic arterial blood pressure by circulatory renin-angiotensin		angiotensin type II receptor activity|receptor antagonist activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|skin(1)	24						GCCTGTTTGTCCTCATTGCCA	0.423000													44	93					0	0	1	0	0
PAX3	5077	broad.mit.edu	37	2	223158461	223158461	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr2:223158461G>A	ENST00000258387.5	-	5	851	c.602C>T	c.(601-603)tCc>tTc	p.S201F	PAX3_ENST00000344493.4_Intron|PAX3_ENST00000409551.3_Intron|PAX3_ENST00000336840.6_Intron|PAX3_ENST00000350526.4_Intron|PAX3_ENST00000392070.2_Intron|PAX3_ENST00000409828.3_3'UTR|PAX3_ENST00000392069.2_Intron	NM_013942.4	NP_039230.1	P23760	PAX3_HUMAN	paired box 3	0					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/NCOA2(4)|PAX3/NCOA1(8)|PAX3/FOXO1(749)	NS(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(13)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	38		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGAAACTCCGGAGACCAGGGC	0.493000			T	"""FOXO1A, NCOA1"""	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						64	73					0	0	1	0	0
BRIP1	83990	broad.mit.edu	37	17	59760893	59760893	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr17:59760893C>T	ENST00000259008.2	-	20	3781	c.3514G>A	c.(3514-3516)Gaa>Aaa	p.E1172K		NM_032043.2	NP_114432.2	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	1172					DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			NS(1)|breast(3)|endometrium(9)|kidney(5)|large_intestine(9)|liver(2)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	55						GTTCTAATTTCAAAAAGGTCT	0.328000			"""F, N, Mis"""			"""AML, leukemia, breast"""		Involved in tolerance or repair of DNA crosslinks					90	11					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12443051	12443051	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr1:12443051C>T	ENST00000358136.3	+	58	11337	c.11207C>T	c.(11206-11208)tCt>tTt	p.S3736F	VPS13D_ENST00000496628.1_3'UTR|VPS13D_ENST00000356315.4_Missense_Mutation_p.S3711F	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	3735					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GGAGGACTTTCTGGTTTGTTT	0.408000													19	66					0	0	1	0	0
KANK2	25959	broad.mit.edu	37	19	11285341	11285341	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr19:11285341C>T	ENST00000432929.2	-	9	2260	c.1900G>A	c.(1900-1902)Gag>Aag	p.E634K	KANK2_ENST00000355150.5_Missense_Mutation_p.E626K|KANK2_ENST00000586659.1_Missense_Mutation_p.E626K|KANK2_ENST00000589359.1_Missense_Mutation_p.E634K|KANK2_ENST00000589894.1_Missense_Mutation_p.E626K	NM_001136191.2	NP_001129663.1	Q63ZY3	KANK2_HUMAN	KN motif and ankyrin repeat domains 2	626										endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						CGCAGCCACTCCTGCAGCACT	0.692000													6	9					0	0	1	0	0
CPXCR1	53336	broad.mit.edu	37	X	88009143	88009143	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chrX:88009143A>C	ENST00000276127.4	+	3	987	c.728A>C	c.(727-729)cAa>cCa	p.Q243P	CPXCR1_ENST00000373111.1_Missense_Mutation_p.Q243P	NM_033048.5	NP_149037	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	243						intracellular	zinc ion binding			NS(1)|cervix(1)|kidney(1)|large_intestine(11)|liver(1)|lung(20)|ovary(3)|upper_aerodigestive_tract(2)	40						TCACAGATACAAATTGAAAGT	0.328000													12	13					0	0	1	0	0
HLA-C	3107	broad.mit.edu	37	6	31238864	31238864	+	Missense_Mutation	SNP	G	G	A	rs17413685		TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr6:31238864G>A	ENST00000383329.3	-	3	619	c.605C>T	c.(604-606)aCg>aTg	p.T202M	HLA-C_ENST00000376228.5_Missense_Mutation_p.T202M			Q9TNN7	1C05_HUMAN	major histocompatibility complex, class I, C	202	Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	17						GCGCTGCAGCGTCTCCTTCCC	0.657000													4	54					0	0	1	0	0
UNC13A	23025	broad.mit.edu	37	19	17735639	17735639	+	Splice_Site	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr19:17735639G>A	ENST00000428389.2	-	36	4459	c.4460C>T	c.(4459-4461)aCg>aTg	p.T1487M	UNC13A_ENST00000551649.1_Splice_Site_p.T1399M|UNC13A_ENST00000252773.7_Splice_Site_p.T1399M|UNC13A_ENST00000550896.1_Splice_Site_p.T1397M|UNC13A_ENST00000519716.2_Splice_Site_p.T1399M|UNC13A_ENST00000552293.1_Splice_Site_p.T1399M			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	1399	MHD2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						AGGTCTCACCGTCTGGTCAGT	0.582000													5	14					0	0	1	0	0
ALDH9A1	223	broad.mit.edu	37	1	165638534	165638534	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr1:165638534G>A	ENST00000354775.4	-	7	1388	c.1084C>T	c.(1084-1086)Cga>Tga	p.R362*	ALDH9A1_ENST00000538148.1_Nonsense_Mutation_p.R268*	NM_000696.3	NP_000687.3	P49189	AL9A1_HUMAN	aldehyde dehydrogenase 9 family, member A1	338					carnitine biosynthetic process|cellular aldehyde metabolic process|hormone metabolic process|neurotransmitter biosynthetic process	cytosol|plasma membrane	3-chloroallyl aldehyde dehydrogenase activity|4-trimethylammoniobutyraldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|aminobutyraldehyde dehydrogenase activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	21	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				NADH(DB00157)	CCAAGGACTCGCTCCAGGTGT	0.463000													46	58					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37879658	37879658	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr17:37879658G>A	ENST00000406381.2	+	19	2453	c.1943G>A	c.(1942-1944)cGg>cAg	p.R648Q	ERBB2_ENST00000269571.5_Missense_Mutation_p.R678Q|ERBB2_ENST00000541774.1_Missense_Mutation_p.R663Q|ERBB2_ENST00000445658.2_Missense_Mutation_p.R402Q|ERBB2_ENST00000584450.1_Missense_Mutation_p.R678Q|ERBB2_ENST00000584601.1_Missense_Mutation_p.R648Q|ERBB2_ENST00000540147.1_Missense_Mutation_p.R648Q	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	678					cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	ATCAAGCGACGGCAGCAGAAG	0.637000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			3	43					0	0	1	0	0
SLC9A8	23315	broad.mit.edu	37	20	48500541	48500541	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr20:48500541G>A	ENST00000417961.1	+	14	1687	c.1477G>A	c.(1477-1479)Gag>Aag	p.E493K	SLC9A8_ENST00000361573.2_Missense_Mutation_p.E477K|SLC9A8_ENST00000541138.1_Missense_Mutation_p.E177K|SLC9A8_ENST00000539601.1_Missense_Mutation_p.E258K	NM_001260491.1|NM_015266.2	NP_001247420.1|NP_056081.1	Q9Y2E8	SL9A8_HUMAN	solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8	477						Golgi membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	30			BRCA - Breast invasive adenocarcinoma(9;3.91e-07)			CATGGACATCGAGGACGCCAA	0.612000													17	59					0	0	1	0	0
KDM6A	7403	broad.mit.edu	37	X	44833960	44833960	+	Splice_Site	SNP	G	G	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chrX:44833960G>T	ENST00000377967.4	+	4	425	c.384G>T	c.(382-384)aaG>aaT	p.K128N	KDM6A_ENST00000543216.1_Splice_Site_p.K128N|KDM6A_ENST00000536777.1_Splice_Site_p.K128N|KDM6A_ENST00000382899.4_Splice_Site_p.K128N	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	128					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0(14)|p.0?(6)|p.?(1)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						ACTACTGGAAGGTTAGTGTAC	0.318000			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								21	48					2.89027e-11	3.07233e-11	1	1	0
DCAF12L2	340578	broad.mit.edu	37	X	125299768	125299768	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chrX:125299768G>A	ENST00000538699.1	-	2	220	c.140C>T	c.(139-141)aCg>aTg	p.T47M	DCAF12L2_ENST00000360028.2_Missense_Mutation_p.T47M	NM_001013628.2	NP_001013650.1	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	47										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(36)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(3)	64						CCTGCGACGCGTCGCCGGCCG	0.736000													6	19					0	0	1	0	0
ZNF441	126068	broad.mit.edu	37	19	11892519	11892519	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr19:11892519C>G	ENST00000357901.4	+	4	1982	c.1880C>G	c.(1879-1881)tCa>tGa	p.S627*	ZNF441_ENST00000454339.2_Nonsense_Mutation_p.S560*	NM_152355.2	NP_689568.2	Q8N8Z8	ZN441_HUMAN	zinc finger protein 441	627					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						TTCAGTCATTCAAGTTACTTA	0.403000													20	31					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140229749	140229749	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr5:140229749G>A	ENST00000378122.3	+	1	2393	c.1669G>A	c.(1669-1671)Gac>Aac	p.D557N	PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA9_ENST00000532602.1_Missense_Mutation_p.D557N|PCDHA7_ENST00000525929.1_Intron|PCDHA1_ENST00000504120.2_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTCGTGCTGGACGAGAACGA	0.687000													26	85					0	0	1	0	0
SPON1	10418	broad.mit.edu	37	11	14277229	14277229	+	RNA	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr11:14277229C>T	ENST00000310358.7	+	0	1664							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		GGAGAAAATCCGGCCCCTGAC	0.493000													25	49					0	0	1	0	0
PODXL2	50512	broad.mit.edu	37	3	127390288	127390288	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr3:127390288G>C	ENST00000342480.6	+	7	1476	c.1437G>C	c.(1435-1437)caG>caC	p.Q479H		NM_015720.2	NP_056535.1	Q9NZ53	PDXL2_HUMAN	podocalyxin-like 2	479					leukocyte tethering or rolling	integral to plasma membrane	glycosaminoglycan binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	26						TTGGCATCCAGAACTATTCCA	0.642000													14	31					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr19:58385546G>T	ENST00000435989.2	-	3	1446	c.1212C>A	c.(1210-1212)gaC>gaA	p.D404E	ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000600634.1_Intron|ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000597832.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.D404E(10)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						AATGTTTTTTGTCAGTGTGAA	0.393000													3	7					2.56e-06	2.61818e-06	1	1	0
ZNF423	23090	broad.mit.edu	37	16	49671201	49671201	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr16:49671201G>A	ENST00000561648.1	-	4	1915	c.1862C>T	c.(1861-1863)tCa>tTa	p.S621L	ZNF423_ENST00000535559.1_Missense_Mutation_p.S504L|ZNF423_ENST00000562871.1_Missense_Mutation_p.S561L|ZNF423_ENST00000563137.2_Missense_Mutation_p.S561L|ZNF423_ENST00000567169.1_Missense_Mutation_p.S504L|ZNF423_ENST00000262383.2_Missense_Mutation_p.S621L|ZNF423_ENST00000562520.1_Missense_Mutation_p.S561L	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	621					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding	p.S621L(2)		breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				GGCGCTTGCTGAGAGCCGCTG	0.567000													21	36					0	0	1	0	0
G2E3	55632	broad.mit.edu	37	14	31074778	31074778	+	Nonsense_Mutation	SNP	A	A	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr14:31074778A>T	ENST00000206595.6	+	11	1232	c.1078A>T	c.(1078-1080)Aaa>Taa	p.K360*	G2E3_ENST00000438909.2_Nonsense_Mutation_p.K314*|G2E3_ENST00000544007.1_Intron|G2E3_ENST00000553504.1_Nonsense_Mutation_p.K390*	NM_017769.3	NP_060239.2	Q7L622	G2E3_HUMAN	G2/M-phase specific E3 ubiquitin protein ligase	360					apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23						AATTAAAAAAAAAACTAAAAG	0.284000													6	12					0	0	1	0	0
ZNF160	90338	broad.mit.edu	37	19	53577475	53577475	+	Silent	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr19:53577475C>T	ENST00000601421.1	-	2	957	c.81G>A	c.(79-81)ggG>ggA	p.G27G	ZNF160_ENST00000355147.5_Silent_p.G63G|ZNF160_ENST00000599056.1_Silent_p.G63G|ZNF160_ENST00000429604.1_Silent_p.G63G|ZNF160_ENST00000418871.1_Silent_p.G63G			Q9HCG1	ZN160_HUMAN	zinc finger protein 160	63	KRAB.				hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.G63G(1)		NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(8)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	35				GBM - Glioblastoma multiforme(134;0.02)		AGGGCTCTTTCCCTTCCTCCA	0.458000													28	39					0	0	1	0	0
TRPM4	54795	broad.mit.edu	37	19	49671814	49671814	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr19:49671814C>T	ENST00000252826.5	+	6	743	c.617C>T	c.(616-618)tCg>tTg	p.S206L	TRPM4_ENST00000355712.5_5'UTR|TRPM4_ENST00000427978.2_Missense_Mutation_p.S206L	NM_017636.3	NP_060106.2	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel, subfamily M, member 4	206					dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(18)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	49		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		CCCTAGGGCTCGTTCCCTGCG	0.647000													19	22					0	0	1	0	0
CYC1	1537	broad.mit.edu	37	8	145150823	145150823	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr8:145150823G>C	ENST00000318911.4	+	2	290	c.217G>C	c.(217-219)Ggg>Cgg	p.G73R		NM_001916.3	NP_001907	P08574	CY1_HUMAN	cytochrome c-1	73					respiratory electron transport chain|transport	cell junction|integral to membrane|mitochondrial inner membrane|respiratory chain	electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity|heme binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)	15	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;8.71e-40)|all cancers(56;3e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AGGGGGTGCGGGGCTGGCCAT	0.647000											OREG0019052	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	75					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33139508	33139508	+	Silent	SNP	T	T	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr6:33139508T>A	ENST00000341947.2	-	42	3359	c.3132A>T	c.(3130-3132)gcA>gcT	p.A1044A	COL11A2_ENST00000395197.1_Silent_p.A984A|COL11A2_ENST00000374714.1_Silent_p.A1018A|COL11A2_ENST00000477772.1_Intron|COL11A2_ENST00000374713.1_Silent_p.A997A|COL11A2_ENST00000374708.4_Silent_p.A958A|COL11A2_ENST00000374712.1_Silent_p.A963A|COL11A2_ENST00000361917.1_Silent_p.A937A|COL11A2_ENST00000357486.1_Silent_p.A1023A	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	1044	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						CTTTCTCTCCTGCTGCTCCAG	0.642000													7	18					0	0	1	0	0
RP11-146E13.4	0	broad.mit.edu	37	14	19857026	19857026	+	RNA	SNP	C	C	G			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr14:19857026C>G	ENST00000548109.1	+	0	72																											TCTCAGCATCCTGGATAATAA	0.378000													12	76					0	0	1	0	0
WHSC1L1	54904	broad.mit.edu	37	8	38205204	38205204	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr8:38205204C>G	ENST00000317025.8	-	2	1003	c.486G>C	c.(484-486)caG>caC	p.Q162H	WHSC1L1_ENST00000527502.1_Missense_Mutation_p.Q162H|WHSC1L1_ENST00000316985.3_Missense_Mutation_p.Q162H|WHSC1L1_ENST00000433384.2_Missense_Mutation_p.Q162H	NM_023034.1	NP_075447.1	Q9BZ95	NSD3_HUMAN	Wolf-Hirschhorn syndrome candidate 1-like 1	162					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			CCCTGCCATTCTGGATAGTTT	0.428000			T	NUP98	AML								103	18					0	0	1	0	0
RAD1	5810	broad.mit.edu	37	5	34908976	34908976	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr5:34908976C>G	ENST00000382038.2	-	6	2162	c.743G>C	c.(742-744)aGa>aCa	p.R248T	RAD1_ENST00000341754.4_Missense_Mutation_p.R248T	NM_002853.3	NP_002844.1	O60671	RAD1_HUMAN	RAD1 homolog (S. pombe)	248					DNA damage checkpoint|DNA repair|DNA replication|meiotic prophase I	nucleoplasm	3'-5' exonuclease activity|damaged DNA binding|exodeoxyribonuclease III activity|protein binding			endometrium(3)|large_intestine(1)|lung(5)|urinary_tract(1)	10	all_lung(31;0.000107)	Lung NSC(810;5.19e-05)|Ovarian(839;0.0448)|Breast(839;0.198)	COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)			AAGGAAGCCTCTGTTATCTGT	0.358000								Other conserved DNA damage response genes					55	77					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	977982	977982	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr12:977982G>C	ENST00000537687.1	+	9	3733	c.3090G>C	c.(3088-3090)ttG>ttC	p.L1030F	WNK1_ENST00000535572.1_Intron|WNK1_ENST00000340908.4_Intron|WNK1_ENST00000315939.6_Intron|WNK1_ENST00000574564.1_Missense_Mutation_p.L329F|WNK1_ENST00000530271.2_Missense_Mutation_p.L1115F	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	786					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CCCCAGAATTGACCGTTTCTG	0.453000													18	53					0	0	1	0	0
PDE6G	5148	broad.mit.edu	37	17	79618682	79618682	+	Silent	SNP	C	C	G			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr17:79618682C>G	ENST00000573076.1	-	3	805	c.330G>C	c.(328-330)ctG>ctC	p.L110L	PDE6G_ENST00000571224.1_Silent_p.L60L|PDE6G_ENST00000331056.5_Silent_p.L60L|PDE6G_ENST00000571004.1_Silent_p.L60L|PDE6G_ENST00000574777.1_5'UTR			P18545	CNRG_HUMAN	phosphodiesterase 6G, cGMP-specific, rod, gamma	60					platelet activation|visual perception	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|enzyme inhibitor activity			lung(2)|urinary_tract(1)	3	all_neural(118;0.0878)|all_lung(278;0.175)|Lung NSC(278;0.192)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			TACCTGTTCCCAGGCCTTCCA	0.677000													15	13					0	0	1	0	0
GAS2L1P2	340508	broad.mit.edu	37	9	99838792	99838792	+	RNA	SNP	G	G	C			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr9:99838792G>C	ENST00000442849.2	-	0	1422					NR_002942.1																						GAGAATGAGGGATGAAGAGGA	0.612000													4	3					0	0	1	0	0
LVRN	206338	broad.mit.edu	37	5	115298620	115298620	+	Silent	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr5:115298620C>T	ENST00000357872.4	+	1	430	c.306C>T	c.(304-306)ctC>ctT	p.L102L	AQPEP_ENST00000395528.2_5'UTR	NM_173800.4	NP_776161.3	Q6Q4G3	AMPQ_HUMAN		102					proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding										CGCCCTGGCTCGTGCCGCTGC	0.701000													18	25					0	0	1	0	0
SLC47A2	146802	broad.mit.edu	37	17	19619812	19619812	+	Silent	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr17:19619812G>A	ENST00000350657.5	-	1	231	c.57C>T	c.(55-57)ctC>ctT	p.L19L	SLC47A2_ENST00000463318.1_Intron|SLC47A2_ENST00000325411.5_Silent_p.L19L	NM_001099646.1|NM_001256663.1	NP_001093116.1|NP_001243592.1	Q86VL8	S47A2_HUMAN	solute carrier family 47 (multidrug and toxin extrusion), member 2	19						integral to membrane|plasma membrane	drug:hydrogen antiporter activity			endometrium(2)|kidney(3)|large_intestine(2)|lung(1)|ovary(1)	9	all_cancers(12;2.3e-05)|all_epithelial(12;0.0024)|Breast(13;0.245)					CCAGCCTGCTGAGGGCAGGGC	0.652000													5	5					0	0	1	0	0
CYP51A1	1595	broad.mit.edu	37	7	91758214	91758214	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr7:91758214C>T	ENST00000003100.8	-	3	613	c.448G>A	c.(448-450)Gca>Aca	p.A150T	LRRD1_ENST00000422722.1_5'UTR|CYP51A1_ENST00000450723.1_Missense_Mutation_p.A45T	NM_000786.3	NP_000777.1	Q16850	CP51A_HUMAN	cytochrome P450, family 51, subfamily A, polypeptide 1	144					cholesterol biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|sterol 14-demethylase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|skin(1)	10	all_cancers(62;2.16e-09)|all_epithelial(64;3.86e-08)|Breast(17;0.00206)|all_lung(186;0.169)|all_hematologic(106;0.215)|Lung NSC(181;0.227)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)		Fluconazole(DB00196)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Miconazole(DB01110)|Terconazole(DB00251)	ACATCGTATGCAACTCCCTTC	0.388000													50	151					0	0	1	0	0
SCRIB	23513	broad.mit.edu	37	8	144895693	144895693	+	Silent	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr8:144895693G>A	ENST00000356994.2	-	5	456	c.450C>T	c.(448-450)ctC>ctT	p.L150L	SCRIB_ENST00000377533.3_Silent_p.L69L|SCRIB_ENST00000320476.3_Silent_p.L150L	NM_182706.4	NP_874365	Q14160	SCRIB_HUMAN	scribbled planar cell polarity protein	150	Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CCAGGTTGGCGAGGCTGAAAG	0.642000													6	49					0	0	1	0	0
SLC27A2	11001	broad.mit.edu	37	15	50518205	50518205	+	Silent	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr15:50518205G>A	ENST00000267842.5	+	6	1420	c.1188G>A	c.(1186-1188)ctG>ctA	p.L396L	SLC27A2_ENST00000544960.1_Silent_p.L161L|SLC27A2_ENST00000380902.4_Silent_p.L343L	NM_003645.3	NP_003636.2	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid transporter), member 2	396					bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			NS(1)|breast(2)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		CTTATGACCTGATTAAATATG	0.308000													20	23					0	0	1	0	0
LIPJ	142910	broad.mit.edu	37	10	90351165	90351165	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr10:90351165G>C	ENST00000371939.3	+	4	354	c.40G>C	c.(40-42)Gat>Cat	p.D14H		NM_001010939.2	NP_001010939.2	Q5W064	LIPJ_HUMAN	lipase, family member J	14					lipid catabolic process		hydrolase activity			large_intestine(4)|lung(4)|ovary(1)	9		all_cancers(4;2.79e-10)|Prostate(4;1.68e-15)|all_epithelial(4;1.43e-09)|Colorectal(252;0.0381)|Breast(4;0.141)|Melanoma(5;0.2)|all_hematologic(4;0.222)		Colorectal(12;1.02e-05)|COAD - Colon adenocarcinoma(12;1.54e-05)		GGGCTACCCTGATGAAGAATA	0.323000													30	33					0	0	1	0	0
DUS1L	64118	broad.mit.edu	37	17	80017830	80017830	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr17:80017830G>C	ENST00000354321.7	-	10	1647	c.1162C>G	c.(1162-1164)Ctg>Gtg	p.L388V	DUS1L_ENST00000306796.5_Missense_Mutation_p.L388V			Q6P1R4	DUS1L_HUMAN	dihydrouridine synthase 1-like (S. cerevisiae)	388					tRNA processing		flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			breast(1)|endometrium(1)|lung(2)|ovary(1)|skin(1)	6	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			TTACGCTTCAGAGAGGGGTCG	0.592000													28	110					0	0	1	0	0
RNASE11	122651	broad.mit.edu	37	14	21052598	21052598	+	Silent	SNP	G	G	A	rs112127139		TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr14:21052598G>A	ENST00000610205.1	-	3	219	c.36C>T	c.(34-36)ggC>ggT	p.G12G	RNASE11_ENST00000398008.2_Silent_p.G12G|RNASE11_ENST00000398009.2_Silent_p.G12G|RNASE11_ENST00000432835.2_Silent_p.G12G|RNASE11_ENST00000553849.1_Silent_p.G12G|RNASE11_ENST00000555283.1_Silent_p.G63G|RNASE11_ENST00000555841.1_Silent_p.G12G	NM_145250.3	NP_660293.1	Q8TAA1	RNS11_HUMAN	ribonuclease, RNase A family, 11 (non-active)							extracellular region	nucleic acid binding|pancreatic ribonuclease activity			endometrium(1)|large_intestine(6)|lung(7)|ovary(3)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	21	all_cancers(95;0.00238)	all_lung(585;0.235)	Epithelial(56;1.85e-06)|all cancers(55;1.46e-05)	GBM - Glioblastoma multiforme(265;0.0139)		CAAGAACCAGGCCCAGGCTGA	0.383000													22	49					0	0	1	0	0
HLA-DRB6	3128	broad.mit.edu	37	6	32522452	32522452	+	RNA	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr6:32522452C>T	ENST00000411500.1	-	0	740					NR_001298.1																						TTTATGAAGTCAGAAAGCTGC	0.493000													8	26					0	0	1	0	0
DCLRE1B	64858	broad.mit.edu	37	1	114454209	114454209	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr1:114454209G>A	ENST00000369563.3	+	4	1441	c.995G>A	c.(994-996)aGa>aAa	p.R332K	DCLRE1B_ENST00000466480.1_3'UTR	NM_022836.3	NP_073747.1	Q9H816	DCR1B_HUMAN	DNA cross-link repair 1B	332					cell cycle checkpoint|DNA repair|protection from non-homologous end joining at telomere|telomeric 3' overhang formation|telomeric loop formation	centrosome|chromosome, telomeric region|nucleus	5'-3' exonuclease activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(6)|stomach(1)	18	Lung SC(450;0.184)	all_cancers(81;1.46e-05)|all_epithelial(167;2.42e-05)|all_lung(203;0.000353)|Lung NSC(69;0.000518)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCTTCCTCTAGAAAACCAAGC	0.522000								Other identified genes with known or suspected DNA repair function					14	47					0	0	1	0	0
KIAA1549	57670	broad.mit.edu	37	7	138554445	138554445	+	Silent	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr7:138554445G>A	ENST00000440172.1	-	14	4662	c.4614C>T	c.(4612-4614)cgC>cgT	p.R1538R	KIAA1549_ENST00000422774.1_Silent_p.R1538R|KIAA1549_ENST00000242365.4_Silent_p.R1488R	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	1538						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						GGCGCTTGGCGCGCAGGCGGA	0.622000			O	BRAF	pilocytic astrocytoma								5	20					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7611659	7611659	+	Silent	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr10:7611659G>A	ENST00000256861.6	-	12	2199	c.2121C>T	c.(2119-2121)ctC>ctT	p.L707L	ITIH5_ENST00000446830.2_Silent_p.L489L|ITIH5_ENST00000298441.6_Silent_p.L493L|ITIH5_ENST00000397146.2_Intron	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	707					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						AGACCAGCCTGAGGATGTCCC	0.562000													8	32					0	0	1	0	0
CEP290	80184	broad.mit.edu	37	12	88500580	88500580	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr12:88500580T>A	ENST00000552810.1	-	25	3032	c.2689A>T	c.(2689-2691)Ata>Tta	p.I897L	CEP290_ENST00000309041.7_Missense_Mutation_p.I899L|CEP290_ENST00000397838.3_5'UTR	NM_025114.3	NP_079390.3	O15078	CE290_HUMAN	centrosomal protein 290kDa	897					cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|liver(1)|lung(18)|ovary(5)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	73						TATTGCCTTATAAGTGATTTT	0.328000													7	10					0	0	1	0	0
FAM127C	441518	broad.mit.edu	37	X	134156399	134156399	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chrX:134156399C>T	ENST00000391440.1	-	1	160	c.91G>A	c.(91-93)Gag>Aag	p.E31K		NM_001078173.1	NP_001071641.1	Q17RB0	F127C_HUMAN	family with sequence similarity 127, member C	31										breast(1)|endometrium(2)|large_intestine(1)|lung(2)	6	Acute lymphoblastic leukemia(192;0.000127)					TCAAACGTCTCGGGAAAGGGA	0.647000													4	115					0	0	1	0	0
MRPS14	63931	broad.mit.edu	37	1	174987587	174987587	+	Silent	SNP	G	G	C			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr1:174987587G>C	ENST00000476371.1	-	2	187	c.171C>G	c.(169-171)ctC>ctG	p.L57L		NM_022100.2	NP_071383.1	O60783	RT14_HUMAN	mitochondrial ribosomal protein S14	57					translation	mitochondrial ribosome	protein binding|structural constituent of ribosome			large_intestine(2)|lung(5)|pancreas(1)|prostate(2)	10						TATTCTTCCTGAGTGAATTAA	0.388000													30	62					0	0	1	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713156	70713156	+	RNA	SNP	G	G	A	rs11629177	by1000genomes	TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr14:70713156G>A	ENST00000530196.1	-	0	1362					NR_003951.1																						TTCCCACAGCGCTTTAGCATA	0.448000													33	50					0	0	1	0	0
MED13L	23389	broad.mit.edu	37	12	116421305	116421305	+	Silent	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr12:116421305C>T	ENST00000281928.3	-	21	4778	c.4572G>A	c.(4570-4572)ttG>ttA	p.L1524L		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1524					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		TAGGTGGTATCAATAGGCTGC	0.507000											OREG0022156	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	16					0	0	1	0	0
DCLK1	9201	broad.mit.edu	37	13	36410271	36410271	+	Silent	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr13:36410271C>T	ENST00000255448.4	-	8	1339	c.1128G>A	c.(1126-1128)tcG>tcA	p.S376S	DCLK1_ENST00000379893.1_Silent_p.S69S|DCLK1_ENST00000360631.3_Silent_p.S376S	NM_004734.4	NP_004725.1	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	376					cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(18)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(6)|urinary_tract(1)	64		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		AGCCTTCCTCCGACACTTCTG	0.353000													27	65					0	0	1	0	0
BRINP2	57795	broad.mit.edu	37	1	177247923	177247923	+	Splice_Site	SNP	T	T	G			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr1:177247923T>G	ENST00000361539.4	+	7	1547		c.e7+2		BRINP2_ENST00000478325.1_Splice_Site	NM_021165.2	NP_066988.1			bone morphogenetic protein/retinoic acid inducible neural-specific 2																		CAAGGAGAGGTGAGCACCCCC	0.607000													6	21					0	0	1	0	0
ABL2	27	broad.mit.edu	37	1	179081513	179081513	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr1:179081513C>T	ENST00000502732.1	-	10	1785	c.1582G>A	c.(1582-1584)Gat>Aat	p.D528N	ABL2_ENST00000511413.1_Missense_Mutation_p.D528N|ABL2_ENST00000344730.3_Missense_Mutation_p.D513N|ABL2_ENST00000392043.3_Missense_Mutation_p.D507N|ABL2_ENST00000504405.1_Missense_Mutation_p.D492N|ABL2_ENST00000512653.1_Missense_Mutation_p.D513N|ABL2_ENST00000408940.3_Missense_Mutation_p.D492N|ABL2_ENST00000367623.4_Missense_Mutation_p.D507N|ABL2_ENST00000507173.1_Missense_Mutation_p.D507N	NM_001168236.1|NM_001168237.1|NM_001168238.1|NM_007314.3	NP_001161708.1|NP_001161709.1|NP_001161710.1|NP_009298.1	P42684	ABL2_HUMAN	c-abl oncogene 2, non-receptor tyrosine kinase	528	Protein kinase.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(8)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	65					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	GAGGGCCTATCGGCAGGGCTC	0.403000			T	ETV6	AML								18	17					0	0	1	0	0
KCNMA1	3778	broad.mit.edu	37	10	79397076	79397076	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr10:79397076G>A	ENST00000286627.5	-	1	1277	c.325C>T	c.(325-327)Cgg>Tgg	p.R109W	KCNMA1_ENST00000406533.3_Missense_Mutation_p.R109W|KCNMA1_ENST00000372443.1_Missense_Mutation_p.R109W|KCNMA1_ENST00000404771.3_Missense_Mutation_p.R109W|KCNMA1_ENST00000480683.1_Missense_Mutation_p.R109W|KCNMA1_ENST00000286628.8_Missense_Mutation_p.R109W|KCNMA1_ENST00000354353.5_Missense_Mutation_p.R109W|KCNMA1_ENST00000481070.1_Missense_Mutation_p.R109W|KCNMA1_ENST00000404857.1_Missense_Mutation_p.R109W|KCNMA1_ENST00000372440.1_Missense_Mutation_p.R109W	NM_001271519.1|NM_002247.3	NP_001258448.1|NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	109					cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	TTGAGCGTCCGCCAGAGCAAG	0.677000													8	41					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37864714	37864714	+	Silent	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr17:37864714G>A	ENST00000406381.2	+	5	786	c.276G>A	c.(274-276)ccG>ccA	p.P92P	ERBB2_ENST00000540042.1_Silent_p.P92P|ERBB2_ENST00000269571.5_Silent_p.P122P|ERBB2_ENST00000541774.1_Silent_p.P107P|ERBB2_ENST00000445658.2_Intron|ERBB2_ENST00000584450.1_Silent_p.P122P|ERBB2_ENST00000584601.1_Silent_p.P92P|ERBB2_ENST00000578199.1_Silent_p.P92P|ERBB2_ENST00000540147.1_Silent_p.P92P	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	122					cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	ATGGAGACCCGCTGAACAATA	0.607000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			4	113					0	0	1	0	0
IQCF1	132141	broad.mit.edu	37	3	51929022	51929022	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr3:51929022A>G	ENST00000310914.5	-	4	564	c.502T>C	c.(502-504)Ttc>Ctc	p.F168L		NM_152397.2	NP_689610.2	Q8N6M8	IQCF1_HUMAN	IQ motif containing F1	168										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)	12				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CCCTTGATGAACCCCCGGGAA	0.582000													4	94					0	0	1	0	0
GATA1	2623	broad.mit.edu	37	X	48650370	48650370	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chrX:48650370G>A	ENST00000376670.3	+	3	451	c.340G>A	c.(340-342)Gag>Aag	p.E114K	GATA1_ENST00000376665.3_Missense_Mutation_p.E114K	NM_002049.3	NP_002040.1	P15976	GATA1_HUMAN	GATA binding protein 1 (globin transcription factor 1)	114					basophil differentiation|eosinophil differentiation|erythrocyte development|megakaryocyte differentiation|platelet aggregation|platelet formation|positive regulation of anti-apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|regulation of glycoprotein biosynthetic process|transcription from RNA polymerase II promoter	nuclear membrane|nucleolus|nucleoplasm	C2H2 zinc finger domain binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.?(2)|p.V77_A120>A(1)|p.E114K(1)		breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(259)|large_intestine(8)|lung(9)|prostate(1)	283						TCCCACCCGCGAGGACTCTCC	0.622000			"""Mis, F"""		megakaryoblastic leukemia of Downs Syndrome								8	31					0	0	1	0	0
UXS1	80146	broad.mit.edu	37	2	106710609	106710609	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr2:106710609G>A	ENST00000283148.7	-	15	1248	c.1151C>T	c.(1150-1152)cCg>cTg	p.P384L	UXS1_ENST00000409501.3_Missense_Mutation_p.P379L|UXS1_ENST00000409032.1_Missense_Mutation_p.P211L|UXS1_ENST00000540130.1_Missense_Mutation_p.P322L	NM_001253875.1|NM_025076.4	NP_001240804.1|NP_079352.2	Q8NBZ7	UXS1_HUMAN	UDP-glucuronate decarboxylase 1	379					cellular metabolic process	Golgi cisterna membrane|integral to membrane	coenzyme binding|UDP-glucuronate decarboxylase activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)	17						TTCCTCCAGCGGGACCTGTTT	0.478000													12	24					0	0	1	0	0
ABCC6	368	broad.mit.edu	37	16	16263639	16263639	+	Silent	SNP	G	G	C			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr16:16263639G>C	ENST00000205557.7	-	22	2888	c.2859C>G	c.(2857-2859)ctC>ctG	p.L953L		NM_001171.5	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	953	ABC transmembrane type-1 2.		L -> H.		response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		GGCAGAGGAAGAGGAAGAGTG	0.662000													3	5					0	0	1	0	0
ILDR1	286676	broad.mit.edu	37	3	121724236	121724236	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr3:121724236G>C	ENST00000273691.3	-	3	339	c.234C>G	c.(232-234)taC>taG	p.Y78*	ILDR1_ENST00000462014.1_Nonsense_Mutation_p.Y90*|ILDR1_ENST00000344209.5_Nonsense_Mutation_p.Y78*|ILDR1_ENST00000460554.1_5'UTR|ILDR1_ENST00000393631.1_Nonsense_Mutation_p.Y78*	NM_175924.3	NP_787120.1	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor 1	78	Ig-like V-type.					cytosol|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(114;0.156)		AAGCTGCCTGGTATGCTGAGG	0.582000													16	19					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56249465	56249465	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr19:56249465C>T	ENST00000332836.2	-	1	303	c.276G>A	c.(274-276)atG>atA	p.M92I		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	92	DAPIN.					cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		ACTTACTTCTCATCTCTTCCT	0.498000													180	257					0	0	1	0	0
ILDR1	286676	broad.mit.edu	37	3	121724238	121724238	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr3:121724238A>T	ENST00000273691.3	-	3	337	c.232T>A	c.(232-234)Tac>Aac	p.Y78N	ILDR1_ENST00000462014.1_Missense_Mutation_p.Y90N|ILDR1_ENST00000344209.5_Missense_Mutation_p.Y78N|ILDR1_ENST00000460554.1_5'UTR|ILDR1_ENST00000393631.1_Missense_Mutation_p.Y78N	NM_175924.3	NP_787120.1	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor 1	78	Ig-like V-type.					cytosol|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(114;0.156)		GCTGCCTGGTATGCTGAGGAG	0.577000													16	19					0	0	1	0	0
PPEF1	5475	broad.mit.edu	37	X	18842187	18842187	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chrX:18842187G>A	ENST00000361511.4	+	17	2142	c.1648G>A	c.(1648-1650)Gaa>Aaa	p.E550K	PPEF1_ENST00000544635.1_Missense_Mutation_p.E485K|PPEF1_ENST00000543630.1_3'UTR|PPEF1_ENST00000349874.5_Missense_Mutation_p.E488K|PPEF1_ENST00000359763.6_Missense_Mutation_p.E497K	NM_006240.2|NM_152224.1	NP_006231.2|NP_689410.1	O14829	PPE1_HUMAN	protein phosphatase, EF-hand calcium binding domain 1	550					detection of stimulus involved in sensory perception|protein dephosphorylation		calcium ion binding|iron ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	43	Hepatocellular(33;0.183)					TATCCGCATTGAAAAACCTGT	0.463000													26	48					0	0	1	0	0
HARBI1	283254	broad.mit.edu	37	11	46637624	46637624	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr11:46637624G>A	ENST00000326737.3	-	2	411	c.164C>T	c.(163-165)gCg>gTg	p.A55V		NM_173811.3	NP_776172.1	Q96MB7	HARB1_HUMAN	harbinger transposase derived 1	55						cytoplasm|nucleus	metal ion binding|nuclease activity			large_intestine(1)|prostate(1)|upper_aerodigestive_tract(1)	3						AGAAAGATTCGCCCCCAAGAG	0.483000													4	23					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140731361	140731361	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr5:140731361G>A	ENST00000523390.1	+	1	1534	c.1534G>A	c.(1534-1536)Gcg>Acg	p.A512T	PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGGTGTTCGCGCAGCGCGC	0.682000													27	34					0	0	1	0	0
FAM171A1	221061	broad.mit.edu	37	10	15290650	15290650	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr10:15290650C>G	ENST00000378116.4	-	5	748	c.742G>C	c.(742-744)Gac>Cac	p.D248H	FAM171A1_ENST00000477161.1_5'UTR	NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	248						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						AGCTTCTGGTCAAACCGCCAC	0.557000													16	46					0	0	1	0	0
LPPR5	163404	broad.mit.edu	37	1	99387478	99387478	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr1:99387478A>G	ENST00000370188.3	-	4	1118	c.758T>C	c.(757-759)aTa>aCa	p.I253T	LPPR5_ENST00000263177.4_Missense_Mutation_p.I253T	NM_001010861.2	NP_001010861.1	Q32ZL2	LPPR5_HUMAN		253						integral to membrane	hydrolase activity										AAAGCCTGCTATAACATCTGA	0.348000													3	71					0	0	1	0	0
CCDC170	80129	broad.mit.edu	37	6	151936602	151936602	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr6:151936602G>A	ENST00000367290.5	+	10	1845	c.1756G>A	c.(1756-1758)Gcc>Acc	p.A586T	CCDC170_ENST00000239374.7_Missense_Mutation_p.A579T			Q8IYT3	CF097_HUMAN	coiled-coil domain containing 170	579																	ACAGACTAAAGCCATTGAAGA	0.363000													45	107					0	0	1	0	0
SNHG7	84973	broad.mit.edu	37	9	139620598	139620598	+	RNA	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr9:139620598G>A	ENST00000414282.1	-	0	451				SNHG7_ENST00000362567.2_RNA|SNHG7_ENST00000416970.1_RNA|SNHG7_ENST00000447221.1_RNA|SNHG7_ENST00000436596.1_RNA																							ACTGGTTCCCGAGCACTGAGT	0.532000													35	8					0	0	1	0	0
OR6C68	403284	broad.mit.edu	37	12	55886505	55886505	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr12:55886505C>T	ENST00000379662.1	+	1	359	c.359C>T	c.(358-360)aCc>aTc	p.T120I	RP11-110A12.2_ENST00000554049.1_RNA|RP11-110A12.2_ENST00000556750.1_RNA|OR6C68_ENST00000548615.1_Missense_Mutation_p.T115I|RP11-110A12.2_ENST00000555138.1_RNA			A6NDL8	O6C68_HUMAN	olfactory receptor, family 6, subfamily C, member 68	115					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	15						CTTTTGGCTACCATGTCATAT	0.373000													34	72					0	0	1	0	0
IGF1R	3480	broad.mit.edu	37	15	99467161	99467161	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr15:99467161A>G	ENST00000268035.6	+	12	3153	c.2542A>G	c.(2542-2544)Atc>Gtc	p.I848V	IGF1R_ENST00000558762.1_Missense_Mutation_p.I848V	NM_000875.3	NP_000866.1	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor	848	Fibronectin type-III 3.				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(13)|lung(20)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	TGAAAACTCCATCTTTTTAAA	0.463000													23	28					0	0	1	0	0
ZNF337	26152	broad.mit.edu	37	20	25656605	25656605	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr20:25656605C>T	ENST00000376436.1	-	4	1858	c.1319G>A	c.(1318-1320)gGa>gAa	p.G440E	RP4-694B14.5_ENST00000414393.1_RNA|ZNF337_ENST00000252979.5_Missense_Mutation_p.G440E|RP4-694B14.5_ENST00000439498.1_RNA|RP4-694B14.5_ENST00000455791.1_RNA|ZNF337_ENST00000538750.1_Missense_Mutation_p.G408E					zinc finger protein 337											breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						CTGAATAAATCCTTGCCCACA	0.443000													31	91					0	0	1	0	0
CNOT1	23019	broad.mit.edu	37	16	58583728	58583728	+	Silent	SNP	G	G	C			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr16:58583728G>C	ENST00000317147.5	-	25	3749	c.3417C>G	c.(3415-3417)gtC>gtG	p.V1139V	CNOT1_ENST00000245138.4_Silent_p.V29V|CNOT1_ENST00000569240.1_Silent_p.V1134V|CNOT1_ENST00000441024.2_Silent_p.V1139V	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1139					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		GCTCAATACTGACTCTCTTCA	0.408000													38	59					0	0	1	0	0
SLC6A19	340024	broad.mit.edu	37	5	1219752	1219752	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr5:1219752C>G	ENST00000304460.10	+	10	1567	c.1511C>G	c.(1510-1512)tCt>tGt	p.S504C		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	504					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GAGATGTTCTCTGTGGTCTAC	0.587000													32	35					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25886731	25886731	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr10:25886731G>A	ENST00000376351.3	+	11	2535	c.2176G>A	c.(2176-2178)Gaa>Aaa	p.E726K	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	726						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						TGCCCAACTGGAAATATATAA	0.423000													81	50					0	0	1	0	0
MGAT3	4248	broad.mit.edu	37	22	39884006	39884006	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr22:39884006C>A	ENST00000341184.6	+	2	869	c.654C>A	c.(652-654)ttC>ttA	p.F218L		NM_001098270.1|NM_002409.4	NP_001091740.1|NP_002400.3	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	218					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	p.F218F(1)		endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|prostate(1)|skin(1)	24	Melanoma(58;0.04)					ACCACGAGTTCGACCTGCTGG	0.652000													7	26					1.06961e-07	1.11936e-07	1	1	0
PDCL	5082	broad.mit.edu	37	9	125588973	125588973	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr9:125588973G>A	ENST00000259467.4	-	2	259	c.94C>T	c.(94-96)Cga>Tga	p.R32*		NM_005388.4	NP_005379.3	Q13371	PHLP_HUMAN	phosducin-like	32					signal transduction|visual perception					endometrium(1)|large_intestine(2)|lung(5)|skin(1)|stomach(1)	10						CATCTGCCTCGGTCCTTGTCC	0.552000													39	20					0	0	1	0	0
ABCA10	10349	broad.mit.edu	37	17	67152025	67152025	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr17:67152025T>A	ENST00000269081.4	-	30	4406	c.3497A>T	c.(3496-3498)gAg>gTg	p.E1166V	ABCA10_ENST00000416101.2_3'UTR|ABCA10_ENST00000519732.1_5'UTR	NM_080282.3	NP_525021.3	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 10	1166					transport	integral to membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(34)|ovary(2)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	81	Breast(10;6.95e-12)					TTCTTCGGGCTCTTCCGGATT	0.423000													72	230					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77325309	77325309	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr16:77325309C>T	ENST00000282849.5	-	21	3674	c.3256G>A	c.(3256-3258)Gga>Aga	p.G1086R		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	1086	TSP type-1 4.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						ATCAGCTTTCCCTGGAAGCCC	0.507000													101	137					0	0	1	0	0
ANKMY2	57037	broad.mit.edu	37	7	16640456	16640456	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr7:16640456G>C	ENST00000306999.2	-	10	1499	c.1256C>G	c.(1255-1257)tCt>tGt	p.S419C		NM_020319.2	NP_064715.1	Q8IV38	ANKY2_HUMAN	ankyrin repeat and MYND domain containing 2	419						cilium	zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|urinary_tract(1)	23	Lung NSC(10;0.103)|all_lung(11;0.204)			UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		GCTTTCAAGAGATTCTTTCTT	0.473000													18	41					0	0	1	0	0
TNK2	10188	broad.mit.edu	37	3	195595153	195595153	+	Silent	SNP	C	C	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr3:195595153C>A	ENST00000333602.6	-	12	2588	c.1971G>T	c.(1969-1971)gcG>gcT	p.A657A	TNK2_ENST00000392400.1_Silent_p.A657A|TNK2_ENST00000428187.1_Silent_p.A689A|TNK2_ENST00000381916.2_Silent_p.A735A	NM_005781.4	NP_005772.3	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2	657	Pro-rich.			Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(11)|ovary(3)|prostate(4)|skin(2)|stomach(1)|urinary_tract(1)	29	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	CAGGGACCCCCGCGCCCACGA	0.706000													11	10					1.58986e-06	1.63841e-06	1	1	0
RNF44	22838	broad.mit.edu	37	5	175959433	175959433	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr5:175959433G>A	ENST00000274811.4	-	2	565	c.41C>T	c.(40-42)tCc>tTc	p.S14F	RNF44_ENST00000537487.1_5'UTR	NM_014901.4	NP_055716.1	Q7L0R7	RNF44_HUMAN	ring finger protein 44	14	Pro-rich.						zinc ion binding			endometrium(2)|lung(3)|prostate(1)|skin(1)|stomach(1)	8	all_cancers(89;0.0029)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CACGGGGGCGGAGGGTGGCCA	0.711000													4	8					0	0	1	0	0
AFMID	125061	broad.mit.edu	37	17	76183502	76183502	+	Translation_Start_Site	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr17:76183502G>A	ENST00000586731.1	+	0	21				AFMID_ENST00000591952.1_Silent_p.K17K|AFMID_ENST00000327898.5_Silent_p.K17K|AFMID_ENST00000588800.1_Silent_p.K17K|AFMID_ENST00000589256.1_Silent_p.K17K|AFMID_ENST00000409257.5_Silent_p.K17K			Q63HM1	AFMID_HUMAN	arylformamidase							cytosol|nucleus	arylformamidase activity			autonomic_ganglia(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|skin(1)	19			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.134)			CTTGGAAGAAGATGTCTGCAG	0.527000													73	39					0	0	1	0	0
TOX	9760	broad.mit.edu	37	8	59728116	59728116	+	Silent	SNP	A	A	G			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr8:59728116A>G	ENST00000361421.1	-	7	1393	c.1173T>C	c.(1171-1173)agT>agC	p.S391S		NM_014729.2	NP_055544.1	O94900	TOX_HUMAN	thymocyte selection-associated high mobility group box	391						nucleus	DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(13)|prostate(1)|skin(2)|stomach(1)	33		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				TCCTGGGGAGACTAGGATGCA	0.557000													25	25					0	0	1	0	0
GRIK4	2900	broad.mit.edu	37	11	120732772	120732772	+	Silent	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr11:120732772G>A	ENST00000527524.2	+	9	1136	c.849G>A	c.(847-849)caG>caA	p.Q283Q	GRIK4_ENST00000438375.2_Silent_p.Q283Q	NM_001282470.1	NP_001269399.1	Q16099	GRIK4_HUMAN	glutamate receptor, ionotropic, kainate 4	283					glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(20)|liver(1)|lung(29)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	69		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	AGTTTGCCCAGAGCCTCAACC	0.542000													82	130					0	0	1	0	0
OR51G2	81282	broad.mit.edu	37	11	4936343	4936343	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr11:4936343C>A	ENST00000322013.3	-	1	579	c.551G>T	c.(550-552)tGt>tTt	p.C184F	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005238.1	NP_001005238.1	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G, member 2	184					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|large_intestine(9)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTGGTGGAGACAATAAGAATG	0.463000													12	34					1.5842e-08	1.67084e-08	1	1	0
POTEH	23784	broad.mit.edu	37	22	16287760	16287760	+	Silent	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr22:16287760G>A	ENST00000343518.6	-	1	177	c.126C>T	c.(124-126)aaC>aaT	p.N42N		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	42										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						AAGTGCCCACGTTGCTCTTGC	0.607000													23	329					0	0	1	0	0
CTC1	80169	broad.mit.edu	37	17	8135439	8135439	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr17:8135439C>T	ENST00000315684.8	-	13	2174	c.2167G>A	c.(2167-2169)Gag>Aag	p.E723K		NM_025099.5	NP_079375.3	Q2NKJ3	CTC1_HUMAN	CTS telomere maintenance complex component 1	723					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding			NS(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(8)|ovary(1)|skin(4)	29						TGGGGTCCCTCTGGGCCGGTG	0.582000													8	5					0	0	1	0	0
CORO7-PAM16	100529144	broad.mit.edu	37	16	4393217	4393217	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr16:4393217C>G	ENST00000572467.1	-	28	2916	c.2848G>C	c.(2848-2850)Gag>Cag	p.E950Q	PAM16_ENST00000318059.3_Missense_Mutation_p.E27Q|CORO7-PAM16_ENST00000572274.1_Intron|PAM16_ENST00000571941.1_Missense_Mutation_p.E47Q|PAM16_ENST00000573553.1_Missense_Mutation_p.E47Q|PAM16_ENST00000577031.1_Missense_Mutation_p.E27Q|PAM16_ENST00000575848.1_Missense_Mutation_p.E39Q|PAM16_ENST00000576217.1_Missense_Mutation_p.E27Q	NM_001201479.1	NP_001188408.1																					CCTGCAAACTCCTGCCGCAAG	0.632000													4	18					0	0	1	0	0
DISP2	85455	broad.mit.edu	37	15	40659810	40659810	+	Silent	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr15:40659810C>T	ENST00000267889.3	+	8	1584	c.1497C>T	c.(1495-1497)atC>atT	p.I499I		NM_033510.1	NP_277045.1	A7MBM2	DISP2_HUMAN	dispatched homolog 2 (Drosophila)	499	SSD.				smoothened signaling pathway	integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)	30		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		TGGTTGCCATCTTCTTCGGCA	0.612000													24	60					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2966266	2966266	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr8:2966266C>T	ENST00000602557.1	-	45	7171	c.6616G>A	c.(6616-6618)Ggt>Agt	p.G2206S	CSMD1_ENST00000602723.1_Missense_Mutation_p.G2206S|CSMD1_ENST00000542608.1_Missense_Mutation_p.G2205S|CSMD1_ENST00000520002.1_Missense_Mutation_p.G2206S|CSMD1_ENST00000400186.3_Missense_Mutation_p.G2206S|CSMD1_ENST00000537824.1_Missense_Mutation_p.G2205S			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2206	CUB 13.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGATCGGGACCGTCCCTAGGA	0.453000													7	19					0	0	1	0	0
HSD17B10	3028	broad.mit.edu	37	X	53460771	53460771	+	Silent	SNP	A	A	G			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chrX:53460771A>G	ENST00000168216.6	-	2	117	c.90T>C	c.(88-90)ctT>ctC	p.L30L	HSD17B10_ENST00000495986.1_5'UTR|HSD17B10_ENST00000375298.4_Silent_p.L30L|HSD17B10_ENST00000375304.5_Silent_p.L30L	NM_001037811.2|NM_004493.2	NP_001032900.1|NP_004484.1	Q99714	HCD2_HUMAN	hydroxysteroid (17-beta) dehydrogenase 10	30					branched chain family amino acid catabolic process|lipid metabolic process|tRNA processing	mitochondrial matrix|plasma membrane	3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity|3-hydroxyacyl-CoA dehydrogenase activity|cholate 7-alpha-dehydrogenase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|skin(1)	8					NADH(DB00157)	CCTGCCCCACAAGTCGCTCCG	0.627000													9	12					0	0	1	0	0
TPTE2P6	374491	broad.mit.edu	37	13	25161397	25161397	+	RNA	SNP	C	C	G	rs3874227	by1000genomes	TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr13:25161397C>G	ENST00000453498.1	+	0	921				TPTE2P6_ENST00000440905.1_RNA																							TGAAACATCTCTACAACTGGA	0.343000													3	52					0	0	1	0	0
SNHG15	285958	broad.mit.edu	37	7	45025006	45025006	+	RNA	SNP	T	T	C			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr7:45025006T>C	ENST00000384215.1	-	0	103					NR_002952.1																						AACCTTGCTCTGGATGGAGCA	0.507000													22	25					0	0	1	0	0
LUZP4	51213	broad.mit.edu	37	X	114536557	114536557	+	Translation_Start_Site	SNP	A	A	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chrX:114536557A>T	ENST00000451986.2	+	0	125				LUZP4_ENST00000371920.3_Splice_Site_p.D31V			Q9P127	LUZP4_HUMAN	leucine zipper protein 4							nucleus				endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	14						TCTAATACAGACGACATTATA	0.299000													26	41					0	0	1	0	0
SPG7	6687	broad.mit.edu	37	16	89619471	89619471	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr16:89619471C>G	ENST00000268704.2	+	14	1879	c.1864C>G	c.(1864-1866)Ctg>Gtg	p.L622V		NM_003119.2	NP_003110.1	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 (pure and complicated autosomal recessive)	622					cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|urinary_tract(1)	20		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		CAAGGAGCAGCTGTTTGAGCG	0.627000													8	16					0	0	1	0	0
TSC1	7248	broad.mit.edu	37	9	135779172	135779172	+	Nonsense_Mutation	SNP	G	G	A	rs118203630		TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr9:135779172G>A	ENST00000298552.3	-	17	2295	c.2074C>T	c.(2074-2076)Cga>Tga	p.R692*	TSC1_ENST00000440111.2_Nonsense_Mutation_p.R692*|TSC1_ENST00000545250.1_Nonsense_Mutation_p.R641*	NM_000368.4|NM_001162426.1|NM_001162427.1	NP_000359.1|NP_001155898.1|NP_001155899.1	Q92574	TSC1_HUMAN	tuberous sclerosis 1	692					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		NS(1)|bone(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(9)|lung(20)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	65				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		AACTGGTCTCGGAGGGTGCGG	0.532000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				31	13					0	0	1	0	0
PNPLA6	10908	broad.mit.edu	37	19	7601354	7601354	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr19:7601354C>A	ENST00000221249.6	+	6	649	c.218C>A	c.(217-219)tCc>tAc	p.S73Y	PNPLA6_ENST00000450331.3_Missense_Mutation_p.S73Y|CTD-2207O23.10_ENST00000601870.1_3'UTR|PNPLA6_ENST00000545201.2_Missense_Mutation_p.S73Y|PNPLA6_ENST00000414982.3_Missense_Mutation_p.S121Y|PNPLA6_ENST00000600737.1_Missense_Mutation_p.S112Y	NM_006702.4	NP_006693.3	Q8IY17	PLPL6_HUMAN	patatin-like phospholipase domain containing 6	112					cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	35						TCCACCTCCTCCCTCGTGGAT	0.552000													20	20					1.2644e-06	1.31304e-06	1	1	0
CRTAC1	55118	broad.mit.edu	37	10	99683047	99683047	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr10:99683047G>A	ENST00000370597.3	-	4	887	c.532C>T	c.(532-534)Cgc>Tgc	p.R178C	CRTAC1_ENST00000298819.4_Missense_Mutation_p.R178C|CRTAC1_ENST00000370591.2_Missense_Mutation_p.R178C	NM_018058.6	NP_060528.3	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1	178						proteinaceous extracellular matrix	calcium ion binding	p.R178C(1)		autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(6)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	35		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		GCCACAGAGCGTCCGGCAAAG	0.592000													42	24					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152527421	152527421	+	Missense_Mutation	SNP	G	G	A	rs147109049		TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr6:152527421G>A	ENST00000367255.5	-	126	23502	c.22901C>T	c.(22900-22902)tCg>tTg	p.S7634L	SYNE1_ENST00000423061.1_Missense_Mutation_p.S7563L|SYNE1_ENST00000265368.4_Missense_Mutation_p.S7634L|SYNE1_ENST00000356820.4_Missense_Mutation_p.S2158L|SYNE1_ENST00000448038.1_Missense_Mutation_p.S7563L|SYNE1_ENST00000341594.5_Missense_Mutation_p.S7246L	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7634					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ACTGTCCGCCGAGAGAAGGAG	0.502000										HNSCC(10;0.0054)			22	38					0	0	1	0	0
ARHGAP35	2909	broad.mit.edu	37	19	47422106	47422106	+	Silent	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr19:47422106C>T	ENST00000404338.3	+	1	174	c.174C>T	c.(172-174)ctC>ctT	p.L58L		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	58					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity										CCTCCGTCCTCAGCACCAGTG	0.527000													25	35					0	0	1	0	0
C15orf26	161502	broad.mit.edu	37	15	81427644	81427644	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr15:81427644A>G	ENST00000286732.4	+	2	186	c.103A>G	c.(103-105)Aag>Gag	p.K35E		NM_173528.2	NP_775799.2	Q6P656	CO026_HUMAN	chromosome 15 open reading frame 26	35										endometrium(1)|kidney(4)|large_intestine(5)|lung(6)|skin(1)	17						GAAGAGAGACAAGGGGAAACT	0.318000													19	28					0	0	1	0	0
WBP4	11193	broad.mit.edu	37	13	41636841	41636841	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr13:41636841G>C	ENST00000379487.3	+	2	464	c.64G>C	c.(64-66)Gac>Cac	p.D22H	WBP4_ENST00000542082.1_Missense_Mutation_p.D22H	NM_007187.3	NP_009118.1	O75554	WBP4_HUMAN	WW domain binding protein 4	22					nuclear mRNA cis splicing, via spliceosome	nuclear speck|spliceosomal complex	nucleic acid binding|proline-rich region binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(2)|prostate(1)|skin(1)	12		Lung NSC(96;3.55e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;3.11e-09)|Epithelial(112;3.37e-06)|OV - Ovarian serous cystadenocarcinoma(117;8.3e-05)|GBM - Glioblastoma multiforme(144;0.00102)|BRCA - Breast invasive adenocarcinoma(63;0.07)		CTGGATAGCAGACAATAGGCC	0.388000													16	26					0	0	1	0	0
AXIN2	8313	broad.mit.edu	37	17	63554321	63554321	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr17:63554321C>G	ENST00000307078.5	-	2	731	c.418G>C	c.(418-420)Gag>Cag	p.E140Q	AXIN2_ENST00000375702.5_Missense_Mutation_p.E140Q|CTD-2535L24.2_ENST00000577662.1_3'UTR	NM_004655.3	NP_004646.3	Q9Y2T1	AXIN2_HUMAN	axin 2	140	RGS.				cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	34						CTGTTGTTCTCAATGTACCTT	0.443000									Oligodontia, Ectodermal Dysplasia and Colorectal Polyp syndrome				324	24					0	0	1	0	0
RHOB	388	broad.mit.edu	37	2	20647449	20647449	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr2:20647449C>A	ENST00000272233.4	+	1	615	c.223C>A	c.(223-225)Ccg>Acg	p.P75T		NM_004040.2	NP_004031.1	P62745	RHOB_HUMAN	ras homolog family member B	75					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			breast(1)|kidney(1)|lung(2)|ovary(1)|urinary_tract(2)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		GCTCTCCTACCCGGACACCGA	0.647000													63	67					4.45325e-31	4.8483e-31	1	1	0
TMPRSS4	56649	broad.mit.edu	37	11	117982463	117982463	+	Silent	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr11:117982463G>A	ENST00000534111.1	+	8	850	c.585G>A	c.(583-585)ggG>ggA	p.G195G	TMPRSS4_ENST00000523251.1_Silent_p.G157G|TMPRSS4_ENST00000522824.1_Silent_p.G192G|TMPRSS4_ENST00000522307.1_Silent_p.G50G|TMPRSS4_ENST00000437212.3_Silent_p.G197G	NM_001083947.1|NM_001173551.1|NM_019894.3	NP_001077416.1|NP_001167022|NP_063947.1	Q9NRS4	TMPS4_HUMAN	transmembrane protease, serine 4	197	SRCR.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			breast(2)|central_nervous_system(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	19	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0431)|all_hematologic(192;0.164)|Breast(348;0.183)|all_neural(223;0.238)		BRCA - Breast invasive adenocarcinoma(274;4.16e-05)|Epithelial(105;0.00204)		CAGCCTGTGGGAAGAGCCTGA	0.602000													15	27					0	0	1	0	0
MINA	84864	broad.mit.edu	37	3	97664163	97664163	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr3:97664163C>A	ENST00000333396.7	-	10	1845	c.1263G>T	c.(1261-1263)ttG>ttT	p.L421F	MINA_ENST00000394198.2_Missense_Mutation_p.L421F|MINA_ENST00000360258.4_Missense_Mutation_p.L420F	NM_001042533.2|NM_032778.5	NP_001035998.1|NP_116167.3	Q8IUF8	MINA_HUMAN	MYC induced nuclear antigen						ribosome biogenesis	cytoplasm|nucleolus				breast(2)|endometrium(1)|large_intestine(1)|lung(8)|ovary(1)	13						CCAAATGTGACAAAGGGAAGC	0.338000													21	40					1.64113e-05	1.66581e-05	1	1	0
LRBA	987	broad.mit.edu	37	4	151223780	151223780	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr4:151223780C>T	ENST00000535741.1	-	53	8487	c.8014G>A	c.(8014-8016)Ggc>Agc	p.G2672S	LRBA_ENST00000357115.3_Missense_Mutation_p.G2683S|LRBA_ENST00000510413.1_Splice_Site_p.G2672S|LRBA_ENST00000503716.1_5'UTR			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	2683						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					TACTTACTGCCTGGGTTATCT	0.368000													14	33					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													4	39					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140176410	140176410	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr5:140176410C>T	ENST00000526136.1	+	1	1861	c.1861C>T	c.(1861-1863)Ccg>Tcg	p.P621S	PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000520672.2_Missense_Mutation_p.P621S|PCDHA2_ENST00000378132.1_Missense_Mutation_p.P621S|PCDHA1_ENST00000504120.2_Intron	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCTCGCATCCCGTTCCGCGT	0.637000													18	58					0	0	1	0	0
PCDHGA12	26025	broad.mit.edu	37	5	140810349	140810349	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr5:140810349G>A	ENST00000252085.3	+	1	165	c.23G>A	c.(22-24)cGg>cAg	p.R8Q	PCDHGA11_ENST00000518882.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA9_ENST00000573521.1_Intron	NM_003735.2|NM_032094.1	NP_003726.1|NP_115265.1														breast(2)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(23)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	58			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGACTGCACCGGGACTACAAA	0.512000													4	79					0	0	1	0	0
PINK1	65018	broad.mit.edu	37	1	20972134	20972134	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr1:20972134delG	ENST00000321556.4	+	5	1135	c.1041delG	c.(1039-1041)ctgfs	p.L347fs	PINK1-AS_ENST00000451424.1_RNA|PINK1_ENST00000492302.1_3'UTR	NM_032409.2	NP_115785.1	Q9BXM7	PINK1_HUMAN	PTEN induced putative kinase 1	347	Protein kinase.		L -> P (in PARK6; strongly reduces interaction with PARK2).		cell death|intracellular protein kinase cascade|mitochondrion degradation|peptidyl-serine phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of release of cytochrome c from mitochondria|regulation of protein complex assembly|regulation of protein ubiquitination|response to stress	cytosol|integral to membrane|mitochondrial outer membrane	ATP binding|C3HC4-type RING finger domain binding|calcium-dependent protein kinase activity|magnesium ion binding|protein serine/threonine kinase activity|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)	14		all_lung(284;2.72e-05)|Lung NSC(340;2.94e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.21e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000146)|Kidney(64;0.000182)|GBM - Glioblastoma multiforme(114;0.000497)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TGCAGCTGCTGGAAGGCGTGG	0.617													12	14	---	---	---	---					
RP11-649A16.1	0	broad.mit.edu	37	3	146995077	146995077	+	RNA	DEL	A	A	-			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr3:146995077delA	ENST00000473299.1	-	0	132																											TCTGGACTGtaaaaaaaaaaa	0.294													4	9	---	---	---	---					
GS1-124K5.2	0	broad.mit.edu	37	7	65888988	65888988	+	RNA	DEL	T	T	-			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr7:65888988delT	ENST00000442578.1	-	0	826																											tttttttttcttttttttttt	0.488													2	4	---	---	---	---					
DLX6	1750	broad.mit.edu	37	7	96635421	96635429	+	In_Frame_Del	DEL	GCCGCCGCC	GCCGCCGCC	-			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr7:96635421_96635429delGCCGCCGCC	ENST00000518156.2	+	1	562_570	c.132_140delGCCGCCGCC	c.(130-141)cagccgccgccg>cag	p.PPP51del	DLX6-AS1_ENST00000458352.2_RNA|DLX6-AS1_ENST00000437331.2_RNA|DLX6-AS1_ENST00000452769.2_RNA|DLX6-AS1_ENST00000437541.1_RNA|DLX6-AS1_ENST00000430404.2_RNA|DLX6-AS1_ENST00000605417.1_RNA|DLX6-AS1_ENST00000430027.3_RNA|DLX6_ENST00000007660.5_Intron			P56179	DLX6_HUMAN	distal-less homeobox 6	0					nervous system development|skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(1)|liver(2)|lung(4)|ovary(2)|urinary_tract(1)	12	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					aacagcaacagccgccgccgccgccgccg	0.713													3	6	---	---	---	---					
NOBOX	135935	broad.mit.edu	37	7	144107246	144107246	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr7:144107246delT	ENST00000467773.1	-	1	74	c.75delA	c.(73-75)aaafs	p.K25fs	NOBOX_ENST00000483238.1_Frame_Shift_Del_p.K25fs	NM_001080413.3	NP_001073882.3	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	25					cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)	26	Melanoma(164;0.14)					CCTCCTGGGCTTTGAAGCCAT	0.517													2	4	---	---	---	---					
FAM66B	100128890	broad.mit.edu	37	8	7196263	7196264	+	RNA	DEL	AC	AC	-			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr8:7196263_7196264delAC	ENST00000606573.1	-	0	703																											ACTGAGGGGTacacacacacac	0.500													3	4	---	---	---	---					
KMT2D	8085	broad.mit.edu	37	12	49420203	49420204	+	Frame_Shift_Ins	INS	-	-	C	rs1064211		TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr12:49420203_49420204insC	ENST00000301067.7	-	48	15544_15545	c.15545_15546insG	c.(15544-15546)ggcfs	p.G5182fs		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D									p.V4914fs*59(2)|p.G5182D(1)|p.G4912D(1)									GGAACACAAGGCCCCCCACACG	0.594													9	35	---	---	---	---					
FRMD6	122786	broad.mit.edu	37	14	52178294	52178295	+	Frame_Shift_Ins	INS	-	-	G			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr14:52178294_52178295insG	ENST00000395718.2	+	8	1021_1022	c.736_737insG	c.(736-738)aggfs	p.R246fs	FRMD6_ENST00000344768.5_Frame_Shift_Ins_p.R254fs|FRMD6_ENST00000356218.4_Frame_Shift_Ins_p.R246fs|FRMD6_ENST00000554167.1_Frame_Shift_Ins_p.R177fs	NM_001267046.1|NM_152330.3	NP_001253975.1|NP_689543.1	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	254	FERM.					cytoskeleton|mitochondrion|plasma membrane	binding			breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(7)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_epithelial(31;0.0163)|Breast(41;0.089)					ATTGACCATGAGGGGAATACAG	0.371													27	50	---	---	---	---					
MYH11	4629	broad.mit.edu	37	16	15814764	15814764	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr16:15814764delG	ENST00000452625.2	-	34	4831	c.4744delC	c.(4744-4746)cagfs	p.Q1582fs	MYH11_ENST00000300036.5_Frame_Shift_Del_p.Q1575fs|NDE1_ENST00000396354.1_Intron|NDE1_ENST00000396355.1_Intron|NDE1_ENST00000342673.5_Intron|MYH11_ENST00000396324.3_Frame_Shift_Del_p.Q1582fs|MYH11_ENST00000576790.2_Frame_Shift_Del_p.Q1575fs	NM_001040113.1	NP_001035202.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1575					axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						CTTTCGAACTGGCCCTTGAGC	0.622			T	CBFB	AML								32	52	---	---	---	---					
PKD1L2	114780	broad.mit.edu	37	16	81253526	81253527	+	RNA	INS	-	-	TTATT	rs140827348	by1000genomes	TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr16:81253526_81253527insTTATT	ENST00000337114.4	-	0	301				PKD1L2_ENST00000525539.1_RNA	NM_001076780.1	NP_001070248.1	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						ttagacatgaattatttaatcc	0.391													3	4	---	---	---	---					
NLRP1	22861	broad.mit.edu	37	17	5487008	5487008	+	Splice_Site	DEL	T	T	-			TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr17:5487008delT	ENST00000345221.3	-	1	824	c.270delA	c.(268-270)gca>gc	p.A90fs	NLRP1_ENST00000577119.1_Splice_Site_p.A90fs|NLRP1_ENST00000269280.4_Splice_Site_p.A90fs|NLRP1_ENST00000262467.5_Splice_Site_p.A90fs|NLRP1_ENST00000572272.1_Splice_Site_p.A90fs|NLRP1_ENST00000354411.3_Splice_Site_p.A90fs|NLRP1_ENST00000571307.1_5'UTR	NM_014922.4|NM_033004.3|NM_033007.3	NP_055737.1|NP_127497.1|NP_127500.1	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1	90	DAPIN.				defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(17)|liver(5)|lung(17)|ovary(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Colorectal(1115;3.48e-05)				TCCACTCACCTGCCCCTTCCT	0.687													2	4	---	---	---	---					
VEZF1	7716	broad.mit.edu	37	17	56056605	56056607	+	In_Frame_Del	DEL	TGC	TGC	-	rs61731354	byFrequency	TCGA-ZF-A9R3-01A-11D-A38G-08	TCGA-ZF-A9R3-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf9f74f-dc4b-464f-af5f-d333424ae66a	285c4dba-3695-4811-99b2-ad383c9dc3fc	g.chr17:56056605_56056607delTGC	ENST00000584396.1	-	5	1105_1107	c.1017_1019delGCA	c.(1015-1020)cagcaa>caa	p.339_340QQ>Q	VEZF1_ENST00000581208.1_In_Frame_Del_p.348_349QQ>Q			Q14119	VEZF1_HUMAN	vascular endothelial zinc finger 1	348					cellular defense response|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|lung(5)|ovary(1)	10						ttgttgttgttgctgctgctgct	0.463													7	598	---	---	---	---					
